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Sample records for realising robust fast

  1. Fast Robust PCA on Graphs

    NASA Astrophysics Data System (ADS)

    Shahid, Nauman; Perraudin, Nathanael; Kalofolias, Vassilis; Puy, Gilles; Vandergheynst, Pierre

    2016-06-01

    Mining useful clusters from high dimensional data has received significant attention of the computer vision and pattern recognition community in the recent years. Linear and non-linear dimensionality reduction has played an important role to overcome the curse of dimensionality. However, often such methods are accompanied with three different problems: high computational complexity (usually associated with the nuclear norm minimization), non-convexity (for matrix factorization methods) and susceptibility to gross corruptions in the data. In this paper we propose a principal component analysis (PCA) based solution that overcomes these three issues and approximates a low-rank recovery method for high dimensional datasets. We target the low-rank recovery by enforcing two types of graph smoothness assumptions, one on the data samples and the other on the features by designing a convex optimization problem. The resulting algorithm is fast, efficient and scalable for huge datasets with O(nlog(n)) computational complexity in the number of data samples. It is also robust to gross corruptions in the dataset as well as to the model parameters. Clustering experiments on 7 benchmark datasets with different types of corruptions and background separation experiments on 3 video datasets show that our proposed model outperforms 10 state-of-the-art dimensionality reduction models. Our theoretical analysis proves that the proposed model is able to recover approximate low-rank representations with a bounded error for clusterable data.

  2. Fast and robust Face Detection

    NASA Astrophysics Data System (ADS)

    Anisetti, Marco

    This chapter presents a fully automatic face detection system robust to moderate change in expression, posture and illumination. The final goal of this detection is to initialize a 3D face tracking, therefore is specialized for working on videos of good quality instead of still images. More in details we present two different face detection strategy based on slightly modified largely used Viola-Jones [1] object detector.

  3. A Fast and Robust Text Spotter

    PubMed Central

    Qin, Siyang; Manduchi, Roberto

    2016-01-01

    We introduce an algorithm for text detection and localization (“spotting”) that is computationally efficient and produces state-of-the-art results. Our system uses multi-channel MSERs to detect a large number of promising regions, then subsamples these regions using a clustering approach. Representatives of region clusters are binarized and then passed on to a deep network. A final line grouping stage forms word-level segments. On the ICDAR 2011 and 2015 benchmarks, our algorithm obtains an F-score of 82% and 83%, respectively, at a computational cost of 1.2 seconds per frame. We also introduce a version that is three times as fast, with only a slight reduction in performance. PMID:27616942

  4. Robust fast controller design via nonlinear fractional differential equations.

    PubMed

    Zhou, Xi; Wei, Yiheng; Liang, Shu; Wang, Yong

    2017-07-01

    A new method for linear system controller design is proposed whereby the closed-loop system achieves both robustness and fast response. The robustness performance considered here means the damping ratio of closed-loop system can keep its desired value under system parameter perturbation, while the fast response, represented by rise time of system output, can be improved by tuning the controller parameter. We exploit techniques from both the nonlinear systems control and the fractional order systems control to derive a novel nonlinear fractional order controller. For theoretical analysis of the closed-loop system performance, two comparison theorems are developed for a class of fractional differential equations. Moreover, the rise time of the closed-loop system can be estimated, which facilitates our controller design to satisfy the fast response performance and maintain the robustness. Finally, numerical examples are given to illustrate the effectiveness of our methods. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  5. Fast and Robust Recursive Algorithmsfor Separable Nonnegative Matrix Factorization.

    PubMed

    Gillis, Nicolas; Vavasis, Stephen A

    2014-04-01

    In this paper, we study the nonnegative matrix factorization problem under the separability assumption (that is, there exists a cone spanned by a small subset of the columns of the input nonnegative data matrix containing all columns), which is equivalent to the hyperspectral unmixing problem under the linear mixing model and the pure-pixel assumption. We present a family of fast recursive algorithms and prove they are robust under any small perturbations of the input data matrix. This family generalizes several existing hyperspectral unmixing algorithms and hence provides for the first time a theoretical justification of their better practical performance.

  6. Fast and Robust Nanocellulose Width Estimation Using Turbidimetry.

    PubMed

    Shimizu, Michiko; Saito, Tsuguyuki; Nishiyama, Yoshiharu; Iwamoto, Shinichiro; Yano, Hiroyuki; Isogai, Akira; Endo, Takashi

    2016-10-01

    The dimensions of nanocelluloses are important factors in controlling their material properties. The present study reports a fast and robust method for estimating the widths of individual nanocellulose particles based on the turbidities of their water dispersions. Seven types of nanocellulose, including short and rigid cellulose nanocrystals and long and flexible cellulose nanofibers, are prepared via different processes. Their widths are calculated from the respective turbidity plots of their water dispersions, based on the theory of light scattering by thin and long particles. The turbidity-derived widths of the seven nanocelluloses range from 2 to 10 nm, and show good correlations with the thicknesses of nanocellulose particles spread on flat mica surfaces determined using atomic force microscopy.

  7. Fast and robust quantum computation with ionic Wigner crystals

    SciTech Connect

    Baltrusch, J. D.; Negretti, A.; Taylor, J. M.; Calarco, T.

    2011-04-15

    We present a detailed analysis of the modulated-carrier quantum phase gate implemented with Wigner crystals of ions confined in Penning traps. We elaborate on a recent scheme, proposed by two of the authors, to engineer two-body interactions between ions in such crystals. We analyze the situation in which the cyclotron ({omega}{sub c}) and the crystal rotation ({omega}{sub r}) frequencies do not fulfill the condition {omega}{sub c}=2{omega}{sub r}. It is shown that even in the presence of the magnetic field in the rotating frame the many-body (classical) Hamiltonian describing small oscillations from the ion equilibrium positions can be recast in canonical form. As a consequence, we are able to demonstrate that fast and robust two-qubit gates are achievable within the current experimental limitations. Moreover, we describe a realization of the state-dependent sign-changing dipole forces needed to realize the investigated quantum computing scheme.

  8. Fast and robust estimation of ophthalmic wavefront aberrations

    NASA Astrophysics Data System (ADS)

    Dillon, Keith

    2016-12-01

    Rapidly rising levels of myopia, particularly in the developing world, have led to an increased need for inexpensive and automated approaches to optometry. A simple and robust technique is provided for estimating major ophthalmic aberrations using a gradient-based wavefront sensor. The approach is based on the use of numerical calculations to produce diverse combinations of phase components, followed by Fourier transforms to calculate the coefficients. The approach does not utilize phase unwrapping nor iterative solution of inverse problems. This makes the method very fast and tolerant to image artifacts, which do not need to be detected and masked or interpolated as is needed in other techniques. These features make it a promising algorithm on which to base low-cost devices for applications that may have limited access to expert maintenance and operation.

  9. Reasoning with Vectors: A Continuous Model for Fast Robust Inference

    PubMed Central

    Widdows, Dominic; Cohen, Trevor

    2015-01-01

    This paper describes the use of continuous vector space models for reasoning with a formal knowledge base. The practical significance of these models is that they support fast, approximate but robust inference and hypothesis generation, which is complementary to the slow, exact, but sometimes brittle behavior of more traditional deduction engines such as theorem provers. The paper explains the way logical connectives can be used in semantic vector models, and summarizes the development of Predication-based Semantic Indexing, which involves the use of Vector Symbolic Architectures to represent the concepts and relationships from a knowledge base of subject-predicate-object triples. Experiments show that the use of continuous models for formal reasoning is not only possible, but already demonstrably effective for some recognized informatics tasks, and showing promise in other traditional problem areas. Examples described in this paper include: predicting new uses for existing drugs in biomedical informatics; removing unwanted meanings from search results in information retrieval and concept navigation; type-inference from attributes; comparing words based on their orthography; and representing tabular data, including modelling numerical values. The algorithms and techniques described in this paper are all publicly released and freely available in the Semantic Vectors open-source software package.1 PMID:26582967

  10. Fast swept-volume distance for robust collision detection

    SciTech Connect

    Xavier, P.G.

    1997-04-01

    The need for collision detection arises in several robotics areas, including motion-planning, online collision avoidance, and simulation. At the heart of most current methods are algorithms for interference detection and/or distance computation. A few recent algorithms and implementations are very fast, but to use them for accurate collision detection, very small step sizes can be necessary, reducing their effective efficiency. We present a fast, implemented technique for doing exact distance computation and interference detection for translationally-swept bodies. For rotationally swept bodies, we adapt this technique to improve accuracy, for any given step size, in distance computation and interference detection. We present preliminary experiments that show that the combination of basic and swept-body calculations holds much promise for faster accurate collision detection.

  11. On FastMap and the convex hull of multivariate data: toward fast and robust dimension reduction.

    PubMed

    Ostrouchov, George; Samatova, Nagiza F

    2005-08-01

    FastMap is a dimension reduction technique that operates on distances between objects. Although only distances are used, implicitly the technique assumes that the objects are points in a p-dimensional Euclidean space. It selects a sequence of k < or = p orthogonal axes defined by distant pairs of points (called pivots) and computes the projection of the points onto the orthogonal axes. We show that FastMap uses only the outer envelope of a data set. Pivots are taken from the faces, usually vertices, of the convex hull of the data points in the original implicit Euclidean space. This provides a bridge to results in robust statistics, where the convex hull is used as a tool in multivariate outlier detection and in robust estimation methods. The connection sheds new light on the properties of FastMap, particularly its sensitivity to outliers, and provides an opportunity for a new class of dimension reduction algorithms, RobustMaps, that retain the speed of FastMap and exploit ideas in robust statistics.

  12. Fast, accurate, robust and Open Source Brain Extraction Tool (OSBET)

    NASA Astrophysics Data System (ADS)

    Namias, R.; Donnelly Kehoe, P.; D'Amato, J. P.; Nagel, J.

    2015-12-01

    The removal of non-brain regions in neuroimaging is a critical task to perform a favorable preprocessing. The skull-stripping depends on different factors including the noise level in the image, the anatomy of the subject being scanned and the acquisition sequence. For these and other reasons, an ideal brain extraction method should be fast, accurate, user friendly, open-source and knowledge based (to allow for the interaction with the algorithm in case the expected outcome is not being obtained), producing stable results and making it possible to automate the process for large datasets. There are already a large number of validated tools to perform this task but none of them meets the desired characteristics. In this paper we introduced an open source brain extraction tool (OSBET), composed of four steps using simple well-known operations such as: optimal thresholding, binary morphology, labeling and geometrical analysis that aims to assemble all the desired features. We present an experiment comparing OSBET with other six state-of-the-art techniques against a publicly available dataset consisting of 40 T1-weighted 3D scans and their corresponding manually segmented images. OSBET gave both: a short duration with an excellent accuracy, getting the best Dice Coefficient metric. Further validation should be performed, for instance, in unhealthy population, to generalize its usage for clinical purposes.

  13. Robust, accurate and fast automatic segmentation of the spinal cord.

    PubMed

    De Leener, Benjamin; Kadoury, Samuel; Cohen-Adad, Julien

    2014-09-01

    Spinal cord segmentation provides measures of atrophy and facilitates group analysis via inter-subject correspondence. Automatizing this procedure enables studies with large throughput and minimizes user bias. Although several automatic segmentation methods exist, they are often restricted in terms of image contrast and field-of-view. This paper presents a new automatic segmentation method (PropSeg) optimized for robustness, accuracy and speed. The algorithm is based on the propagation of a deformable model and is divided into three parts: firstly, an initialization step detects the spinal cord position and orientation using a circular Hough transform on multiple axial slices rostral and caudal to the starting plane and builds an initial elliptical tubular mesh. Secondly, a low-resolution deformable model is propagated along the spinal cord. To deal with highly variable contrast levels between the spinal cord and the cerebrospinal fluid, the deformation is coupled with a local contrast-to-noise adaptation at each iteration. Thirdly, a refinement process and a global deformation are applied on the propagated mesh to provide an accurate segmentation of the spinal cord. Validation was performed in 15 healthy subjects and two patients with spinal cord injury, using T1- and T2-weighted images of the entire spinal cord and on multiecho T2*-weighted images. Our method was compared against manual segmentation and against an active surface method. Results show high precision for all the MR sequences. Dice coefficients were 0.9 for the T1- and T2-weighted cohorts and 0.86 for the T2*-weighted images. The proposed method runs in less than 1min on a normal computer and can be used to quantify morphological features such as cross-sectional area along the whole spinal cord.

  14. Robust and fast nonlinear optimization of diffusion MRI microstructure models.

    PubMed

    Harms, R L; Fritz, F J; Tobisch, A; Goebel, R; Roebroeck, A

    2017-07-15

    run time, fit, accuracy and precision. Parameter initialization approaches were found to be relevant especially for more complex models, such as those involving several fiber orientations per voxel. For these, a fitting cascade initializing or fixing parameter values in a later optimization step from simpler models in an earlier optimization step further improved run time, fit, accuracy and precision compared to a single step fit. This establishes and makes available standards by which robust fit and accuracy can be achieved in shorter run times. This is especially relevant for the use of diffusion microstructure modeling in large group or population studies and in combining microstructure parameter maps with tractography results. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  15. Fast and Robust Segmentation and Classification for Change Detection in Urban Point Clouds

    NASA Astrophysics Data System (ADS)

    Roynard, X.; Deschaud, J.-E.; Goulette, F.

    2016-06-01

    Change detection is an important issue in city monitoring to analyse street furniture, road works, car parking, etc. For example, parking surveys are needed but are currently a laborious task involving sending operators in the streets to identify the changes in car locations. In this paper, we propose a method that performs a fast and robust segmentation and classification of urban point clouds, that can be used for change detection. We apply this method to detect the cars, as a particular object class, in order to perform parking surveys automatically. A recently proposed method already addresses the need for fast segmentation and classification of urban point clouds, using elevation images. The interest to work on images is that processing is much faster, proven and robust. However there may be a loss of information in complex 3D cases: for example when objects are one above the other, typically a car under a tree or a pedestrian under a balcony. In this paper we propose a method that retain the three-dimensional information while preserving fast computation times and improving segmentation and classification accuracy. It is based on fast region-growing using an octree, for the segmentation, and specific descriptors with Random-Forest for the classification. Experiments have been performed on large urban point clouds acquired by Mobile Laser Scanning. They show that the method is as fast as the state of the art, and that it gives more robust results in the complex 3D cases.

  16. Fast and Robust Registration of Multimodal Remote Sensing Images via Dense Orientated Gradient Feature

    NASA Astrophysics Data System (ADS)

    Ye, Y.

    2017-09-01

    This paper presents a fast and robust method for the registration of multimodal remote sensing data (e.g., optical, LiDAR, SAR and map). The proposed method is based on the hypothesis that structural similarity between images is preserved across different modalities. In the definition of the proposed method, we first develop a pixel-wise feature descriptor named Dense Orientated Gradient Histogram (DOGH), which can be computed effectively at every pixel and is robust to non-linear intensity differences between images. Then a fast similarity metric based on DOGH is built in frequency domain using the Fast Fourier Transform (FFT) technique. Finally, a template matching scheme is applied to detect tie points between images. Experimental results on different types of multimodal remote sensing images show that the proposed similarity metric has the superior matching performance and computational efficiency than the state-of-the-art methods. Moreover, based on the proposed similarity metric, we also design a fast and robust automatic registration system for multimodal images. This system has been evaluated using a pair of very large SAR and optical images (more than 20000 × 20000 pixels). Experimental results show that our system outperforms the two popular commercial software systems (i.e. ENVI and ERDAS) in both registration accuracy and computational efficiency.

  17. A Matrix Computation View of the FastMap and RobustMap Dimension Reduction Algorithms

    SciTech Connect

    Ostrouchov, George

    2009-01-01

    Given a set of pairwise object distances and a dimension $k$, FastMap and RobustMap algorithms compute a set of $k$-dimensional coordinates for the objects. These metric space embedding methods implicitly assume a higher-dimensional coordinate representation and are a sequence of translations and orthogonal projections based on a sequence of object pair selections (called pivot pairs). We develop a matrix computation viewpoint of these algorithms that operates on the coordinate representation explicitly using Householder reflections. The resulting Coordinate Mapping Algorithm (CMA) is a fast approximate alternative to truncated principal component analysis (PCA) and it brings the FastMap and RobustMap algorithms into the mainstream of numerical computation where standard BLAS building blocks are used. Motivated by the geometric nature of the embedding methods, we further show that truncated PCA can be computed with CMA by specific pivot pair selections. Describing FastMap, RobustMap, and PCA as CMA computations with different pivot pair choices unifies the methods along a pivot pair selection spectrum. We also sketch connections to the semi-discrete decomposition and the QLP decomposition.

  18. Optimal Local Searching for Fast and Robust Textureless 3D Object Tracking in Highly Cluttered Backgrounds.

    PubMed

    Seo, Byung-Kuk; Park, Jong-Il; Hinterstoisser, Stefan; Ilic, Slobodan

    2013-06-13

    Edge-based tracking is a fast and plausible approach for textureless 3D object tracking, but its robustness is still very challenging in highly cluttered backgrounds due to numerous local minima. To overcome this problem, we propose a novel method for fast and robust textureless 3D object tracking in highly cluttered backgrounds. The proposed method is based on optimal local searching of 3D-2D correspondences between a known 3D object model and 2D scene edges in an image with heavy background clutter. In our searching scheme, searching regions are partitioned into three levels (interior, contour, and exterior) with respect to the previous object region, and confident searching directions are determined by evaluating candidates of correspondences on their region levels; thus, the correspondences are searched among likely candidates in only the confident directions instead of searching through all candidates. To ensure the confident searching direction, we also adopt the region appearance, which is efficiently modeled on a newly defined local space (called a searching bundle). Experimental results and performance evaluations demonstrate that our method fully supports fast and robust textureless 3D object tracking even in highly cluttered backgrounds.

  19. Optimal local searching for fast and robust textureless 3D object tracking in highly cluttered backgrounds.

    PubMed

    Seo, Byung-Kuk; Park, Hanhoon; Park, Jong-Il; Hinterstoisser, Stefan; Ilic, Slobodan

    2014-01-01

    Edge-based tracking is a fast and plausible approach for textureless 3D object tracking, but its robustness is still very challenging in highly cluttered backgrounds due to numerous local minima. To overcome this problem, we propose a novel method for fast and robust textureless 3D object tracking in highly cluttered backgrounds. The proposed method is based on optimal local searching of 3D-2D correspondences between a known 3D object model and 2D scene edges in an image with heavy background clutter. In our searching scheme, searching regions are partitioned into three levels (interior, contour, and exterior) with respect to the previous object region, and confident searching directions are determined by evaluating candidates of correspondences on their region levels; thus, the correspondences are searched among likely candidates in only the confident directions instead of searching through all candidates. To ensure the confident searching direction, we also adopt the region appearance, which is efficiently modeled on a newly defined local space (called a searching bundle). Experimental results and performance evaluations demonstrate that our method fully supports fast and robust textureless 3D object tracking even in highly cluttered backgrounds.

  20. Fast dose algorithm for generation of dose coverage probability for robustness analysis of fractionated radiotherapy

    NASA Astrophysics Data System (ADS)

    Tilly, David; Ahnesjö, Anders

    2015-07-01

    A fast algorithm is constructed to facilitate dose calculation for a large number of randomly sampled treatment scenarios, each representing a possible realisation of a full treatment with geometric, fraction specific displacements for an arbitrary number of fractions. The algorithm is applied to construct a dose volume coverage probability map (DVCM) based on dose calculated for several hundred treatment scenarios to enable the probabilistic evaluation of a treatment plan. For each treatment scenario, the algorithm calculates the total dose by perturbing a pre-calculated dose, separately for the primary and scatter dose components, for the nominal conditions. The ratio of the scenario specific accumulated fluence, and the average fluence for an infinite number of fractions is used to perturb the pre-calculated dose. Irregularities in the accumulated fluence may cause numerical instabilities in the ratio, which is mitigated by regularisation through convolution with a dose pencil kernel. Compared to full dose calculations the algorithm demonstrates a speedup factor of ~1000. The comparisons to full calculations show a 99% gamma index (2%/2 mm) pass rate for a single highly modulated beam in a virtual water phantom subject to setup errors during five fractions. The gamma comparison shows a 100% pass rate in a moving tumour irradiated by a single beam in a lung-like virtual phantom. DVCM iso-probability lines computed with the fast algorithm, and with full dose calculation for each of the fractions, for a hypo-fractionated prostate case treated with rotational arc therapy treatment were almost indistinguishable.

  1. Fast dose algorithm for generation of dose coverage probability for robustness analysis of fractionated radiotherapy.

    PubMed

    Tilly, David; Ahnesjö, Anders

    2015-07-21

    A fast algorithm is constructed to facilitate dose calculation for a large number of randomly sampled treatment scenarios, each representing a possible realisation of a full treatment with geometric, fraction specific displacements for an arbitrary number of fractions. The algorithm is applied to construct a dose volume coverage probability map (DVCM) based on dose calculated for several hundred treatment scenarios to enable the probabilistic evaluation of a treatment plan.For each treatment scenario, the algorithm calculates the total dose by perturbing a pre-calculated dose, separately for the primary and scatter dose components, for the nominal conditions. The ratio of the scenario specific accumulated fluence, and the average fluence for an infinite number of fractions is used to perturb the pre-calculated dose. Irregularities in the accumulated fluence may cause numerical instabilities in the ratio, which is mitigated by regularisation through convolution with a dose pencil kernel.Compared to full dose calculations the algorithm demonstrates a speedup factor of ~1000. The comparisons to full calculations show a 99% gamma index (2%/2 mm) pass rate for a single highly modulated beam in a virtual water phantom subject to setup errors during five fractions. The gamma comparison shows a 100% pass rate in a moving tumour irradiated by a single beam in a lung-like virtual phantom. DVCM iso-probability lines computed with the fast algorithm, and with full dose calculation for each of the fractions, for a hypo-fractionated prostate case treated with rotational arc therapy treatment were almost indistinguishable.

  2. a Fast and Robust Algorithm for Road Edges Extraction from LIDAR Data

    NASA Astrophysics Data System (ADS)

    Qiu, Kaijin; Sun, Kai; Ding, Kou; Shu, Zhen

    2016-06-01

    Fast mapping of roads plays an important role in many geospatial applications, such as infrastructure planning, traffic monitoring, and driver assistance. How to extract various road edges fast and robustly is a challenging task. In this paper, we present a fast and robust algorithm for the automatic road edges extraction from terrestrial mobile LiDAR data. The algorithm is based on a key observation: most roads around edges have difference in elevation and road edges with pavement are seen in two different planes. In our algorithm, we firstly extract a rough plane based on RANSAC algorithm, and then multiple refined planes which only contains pavement are extracted from the rough plane. The road edges are extracted based on these refined planes. In practice, there is a serious problem that the rough and refined planes usually extracted badly due to rough roads and different density of point cloud. To eliminate the influence of rough roads, the technology which is similar with the difference of DSM (digital surface model) and DTM (digital terrain model) is used, and we also propose a method which adjust the point clouds to a similar density to eliminate the influence of different density. Experiments show the validities of the proposed method with multiple datasets (e.g. urban road, highway, and some rural road). We use the same parameters through the experiments and our algorithm can achieve real-time processing speeds.

  3. GA-Based Autonomous Design of Robust Fast and Precise Positioning Considering Machine Stand Vibration Suppression

    NASA Astrophysics Data System (ADS)

    Ito, Kazuaki; Nagata, Ryo; Iwasaki, Makoto; Matsui, Nobuyuki

    This paper presents a novel Genetic Algorithm (GA)-based autonomous compensator design and position command shaping considering the stand vibration suppression for the fast-response and high-precision positioning of mechatronic systems. The positioning system is mainly composed of a robust 2-degrees-of-freedom (2DOF) controller based on the coprime factorization description. The feedback compensator based on H∞ design framework in the 2DOF controller ensures the robustness against the variations of resonant vibration mode. The feedforward compensator and position command, on the other hand, can be autonomously designed by the optimization capability of GA, in order to achieve the desired positioning performance and to suppress the machine stand vibration. The effectiveness of the proposed optimal design has been verified by experiments using a table drive system with ball screw.

  4. A robust and fast line segment detector based on top-down smaller eigenvalue analysis

    NASA Astrophysics Data System (ADS)

    Liu, Dong; Wang, Yongtao; Tang, Zhi; Lu, Xiaoqing

    2014-01-01

    In this paper, we propose a robust and fast line segment detector, which achieves accurate results with a controlled number of false detections and requires no parameter tuning. It consists of three steps: first, we propose a novel edge point chaining method to extract Canny edge segments (i.e., contiguous chains of Canny edge points) from the input image; second, we propose a top-down scheme based on smaller eigenvalue analysis to extract line segments within each obtained edge segment; third, we employ Desolneux et al.'s method to reject false detections. Experiments demonstrate that it is very efficient and more robust than two state of the art methods—LSD and EDLines.

  5. Robust Detection of Fast and Slow Frequency Jumps of Atomic Clocks.

    PubMed

    Galleani, Lorenzo; Tavella, Patrizia

    2017-02-01

    This paper presents a frequency jump detector for atomic clocks. The detector considers both fast frequency jumps, which are abrupt variations of the clock frequency trend, and slow frequency jumps, which correspond to variations of the frequency trend over a finite time interval. These anomalies are particularly critical to space clocks in global navigation satellite systems (GNSSs). The developed detector is robust in the sense that it can deal with time-varying frequency trends, sinusoidal terms, outliers, and missing data. The detection performances are analyzed both analytically and numerically, and the effectiveness of the detector is shown by applying it to GNSS experimental data, as well as to simulated clock data.

  6. Robustness

    NASA Technical Reports Server (NTRS)

    Ryan, R.

    1993-01-01

    Robustness is a buzz word common to all newly proposed space systems design as well as many new commercial products. The image that one conjures up when the word appears is a 'Paul Bunyon' (lumberjack design), strong and hearty; healthy with margins in all aspects of the design. In actuality, robustness is much broader in scope than margins, including such factors as simplicity, redundancy, desensitization to parameter variations, control of parameter variations (environments flucation), and operational approaches. These must be traded with concepts, materials, and fabrication approaches against the criteria of performance, cost, and reliability. This includes manufacturing, assembly, processing, checkout, and operations. The design engineer or project chief is faced with finding ways and means to inculcate robustness into an operational design. First, however, be sure he understands the definition and goals of robustness. This paper will deal with these issues as well as the need for the requirement for robustness.

  7. Robust stabilization of underactuated nonlinear systems: A fast terminal sliding mode approach.

    PubMed

    Khan, Qudrat; Akmeliawati, Rini; Bhatti, Aamer Iqbal; Khan, Mahmood Ashraf

    2017-01-01

    This paper presents a fast terminal sliding mode based control design strategy for a class of uncertain underactuated nonlinear systems. Strategically, this development encompasses those electro-mechanical underactuated systems which can be transformed into the so-called regular form. The novelty of the proposed technique lies in the hierarchical development of a fast terminal sliding attractor design for the considered class. Having established sliding mode along the designed manifold, the close loop dynamics become finite time stable which, consequently, result in high precision. In addition, the adverse effects of the chattering phenomenon are reduced via strong reachability condition and the robustness of the system against uncertainties is confirmed theoretically. A simulation as well as experimental study of an inverted pendulum is presented to demonstrate the applicability of the proposed technique.

  8. Fast and robust chromatic dispersion estimation based on temporal auto-correlation after digital spectrum superposition.

    PubMed

    Yao, Shuchang; Eriksson, Tobias A; Fu, Songnian; Johannisson, Pontus; Karlsson, Magnus; Andrekson, Peter A; Ming, Tang; Liu, Deming

    2015-06-15

    We investigate and experimentally demonstrate a fast and robust chromatic dispersion (CD) estimation method based on temporal auto-correlation after digital spectrum superposition. The estimation process is fast, because neither tentative CD scanning based on CD compensation nor specific cost function calculations are used. Meanwhile, the proposed CD estimation method is robust against polarization mode dispersion (PMD), amplified spontaneous emission (ASE) noise and fiber nonlinearity. Furthermore, the proposed CD estimation method can be used for various modulation formats and digital pulse shaping technique. Only 4096 samples are necessary for CD estimation of single carrier either 112 Gbps DP-QPSK or 224 Gbps DP-16QAM signal with various pulse shapes. 8192 samples are sufficient for the root-raised-cosine pulse with roll-off factor of 0.1. As low as 50 ps/nm standard deviation together with a worst estimation error of about 160 ps/nm is experimentally obtained for 7×112 Gbps DP-QPSK WDM signal after the transmission through 480 km to 9120 km single mode fiber (SMF) loop using different launch powers.

  9. Development of a robust and fast calibration procedure for diffuse optical tomography

    NASA Astrophysics Data System (ADS)

    Xu, Chen; Li, Hai; Yuan, Guangqian; Vavadi, Hamed; Zhu, Quing

    2015-03-01

    Near infrared (NIR) diffuse optical tomography has demonstrated great potential in the initial diagnosis of tumor and the assessment of tumor vasculature response to neoadjuvant chemotherapy. A fast and robust data processing is critical to move this technique from lab research to bench-side application. Our lab developed frequency-domain diffuse optical tomography system for clinical applications. So far, we still collect data at hospital and do the data processing off-line. In this paper, a robust calibration procedure and fast processing program were developed to overcome this limitation. Because each detection channel had its own electronic delay, the calibration procedure measured amplitude linearity and phase linearity of each channel, and formed a look-up table. The experimental measurements were corrected by the table and the fitting accuracy improved by 45.8%. To further improve the processing speed, the data collection and processing program were converted to C++ from matlab program. The overall processing speed was improved by two times. We expect the new processing program can move diffuse optical tomography one step close to bench-side clinical applications.

  10. Real-Time Robust Tracking for Motion Blur and Fast Motion via Correlation Filters

    PubMed Central

    Xu, Lingyun; Luo, Haibo; Hui, Bin; Chang, Zheng

    2016-01-01

    Visual tracking has extensive applications in intelligent monitoring and guidance systems. Among state-of-the-art tracking algorithms, Correlation Filter methods perform favorably in robustness, accuracy and speed. However, it also has shortcomings when dealing with pervasive target scale variation, motion blur and fast motion. In this paper we proposed a new real-time robust scheme based on Kernelized Correlation Filter (KCF) to significantly improve performance on motion blur and fast motion. By fusing KCF and STC trackers, our algorithm also solve the estimation of scale variation in many scenarios. We theoretically analyze the problem for CFs towards motions and utilize the point sharpness function of the target patch to evaluate the motion state of target. Then we set up an efficient scheme to handle the motion and scale variation without much time consuming. Our algorithm preserves the properties of KCF besides the ability to handle special scenarios. In the end extensive experimental results on benchmark of VOT datasets show our algorithm performs advantageously competed with the top-rank trackers. PMID:27618046

  11. Fast, Robust Evaluation of the Equation of State of Suspensions of Charge-Stabilized Colloidal Spheres.

    PubMed

    Hallez, Yannick; Meireles, Martine

    2017-09-26

    Increasing demand is appearing for the fast, robust prediction of the equation of state of colloidal suspensions, notably with a view to using it as input data to calculate transport coefficients in complex flow solvers. This is also of interest in rheological studies, industrial screening tests of new formulations, and the real-time interpretation of osmotic compression experiments, for example. For charge-stabilized spherical particles, the osmotic pressure can be computed with standard liquid theories. However, this calculation can sometimes be lengthy and/or unstable under some physicochemical conditions, a drawback that precludes its use in multiscale flow simulators. As a simple, fast, and robust replacement, the literature reports estimations of the osmotic pressure that have been built by adding the Carnahan-Starling and the cell model pressures (CSCM model). The first contribution is intended to account for colloid-colloid contacts, and the second, for electrostatic effects. This approximation has not yet been thoroughly tested. In this work, the CSCM is evaluated by comparison with data from experiments on silica particles, Monte Carlo simulations, and solutions of the accurate Rogers-Young integral equation scheme with a hard-sphere Yukawa potential obtained from the extrapolated point-charge renormalization method for a wide range of volume fractions, surface charge densities, and interaction ranges. We find that the CSCM is indeed perfectly adequate in the electrostatically concentrated regime, where it can be used from vanishingly small to high surface charge because there is error cancellation between the Carnahan-Starling and cell model contributions at intermediate charge. The CSCM is thus a nice extension of the cell model to liquid-like dense suspensions, which should find application in the domains mentioned above. However, it fails for dilute suspensions with strong electrostatics. In this case, we show that, and explain why, perturbation

  12. Robust and fast license plate detection based on the fusion of color and edge feature

    NASA Astrophysics Data System (ADS)

    Cai, De; Shi, Zhonghan; Liu, Jin; Hu, Chuanping; Mei, Lin; Qi, Li

    2014-11-01

    Extracting a license plate is an important stage in automatic vehicle identification. The degradation of images and the computation intense make this task difficult. In this paper, a robust and fast license plate detection based on the fusion of color and edge feature is proposed. Based on the dichromatic reflection model, two new color ratios computed from the RGB color model are introduced and proved to be two color invariants. The global color feature extracted by the new color invariants improves the method's robustness. The local Sobel edge feature guarantees the method's accuracy. In the experiment, the detection performance is good. The detection results show that this paper's method is robust to the illumination, object geometry and the disturbance around the license plates. The method can also detect license plates when the color of the car body is the same as the color of the plates. The processing time for image size of 1000x1000 by pixels is nearly 0.2s. Based on the comparison, the performance of the new ratios is comparable to the common used HSI color model.

  13. Fast and robust identification of single bacteria in environmental matrices by Raman spectroscopy

    NASA Astrophysics Data System (ADS)

    Baritaux, Jean-Charles; Schultz, Emmanuelle; Simon, Anne-Catherine; Bourdat, Anne-Gaelle; Espagnon, Isabelle; Laurent, Patricia; Dinten, Jean-Marc

    2015-03-01

    We report on our recent results on robust identification of single bacterial cells embedded in various environments using Spontaneous Raman Scattering. Five species of bacteria were considered, two of which (B. Subtilis and E. Coli) were grown under various conditions, or embedded in two real-world matrices. We recorded the Raman spectra of single cells with a confocal instrument developed in our lab, and performed identification at the species level. Our system integrates a Lensfree imaging module that allows fast detection of bacteria over a large Field-Of-View. Identification rates comparable to those obtained on lab cultures were possible using a comprehensive database containing spectra from bacteria in all environments. In addition, B. Subtilis was correctly identified in 95.5% of the cases using a database composed exclusively of spectra obtained in standard conditions. This is very promising for pathogen threat detection where the construction of an exhaustive database may be challenging.

  14. Fast and robust exo-planet detection in multi-spectral, multi-temporal data

    NASA Astrophysics Data System (ADS)

    Thiébaut, Éric; Denis, Loïc.; Mugnier, Laurent; Ferrari, André; Mary, David; Langlois, Maud; Cantalloube, Faustine; Devaney, Nicholas

    2016-07-01

    Exo-planet detection is a signal processing problem that can be addressed by several detection approaches. This paper provides a review of methods from detection theory that can be applied to detect exo-planets in coronographic images such as those provided by SPHERE and GPI. In a first part, we recall the basics of signal detection and describe how to derive a fast and robust detection criterion based on a heavy tail model that can account for outliers in the residuals. In a second part, we derive detectors that handle jointly several wavelengths and exposures and focus on an approach that prevents from interpolating the data, thereby preserving the statistics of the original data.

  15. SERF: A Simple, Effective, Robust, and Fast Image Super-Resolver From Cascaded Linear Regression.

    PubMed

    Hu, Yanting; Wang, Nannan; Tao, Dacheng; Gao, Xinbo; Li, Xuelong

    2016-09-01

    Example learning-based image super-resolution techniques estimate a high-resolution image from a low-resolution input image by relying on high- and low-resolution image pairs. An important issue for these techniques is how to model the relationship between high- and low-resolution image patches: most existing complex models either generalize hard to diverse natural images or require a lot of time for model training, while simple models have limited representation capability. In this paper, we propose a simple, effective, robust, and fast (SERF) image super-resolver for image super-resolution. The proposed super-resolver is based on a series of linear least squares functions, namely, cascaded linear regression. It has few parameters to control the model and is thus able to robustly adapt to different image data sets and experimental settings. The linear least square functions lead to closed form solutions and therefore achieve computationally efficient implementations. To effectively decrease these gaps, we group image patches into clusters via k-means algorithm and learn a linear regressor for each cluster at each iteration. The cascaded learning process gradually decreases the gap of high-frequency detail between the estimated high-resolution image patch and the ground truth image patch and simultaneously obtains the linear regression parameters. Experimental results show that the proposed method achieves superior performance with lower time consumption than the state-of-the-art methods.

  16. High-resolution imaging without iteration: a fast and robust method for breast ultrasound tomography.

    PubMed

    Huthwaite, P; Simonetti, F

    2011-09-01

    Breast ultrasound tomography has the potential to improve the cost, safety, and reliability of breast cancer screening and diagnosis over the gold-standard of mammography. Vital to achieving this potential is the development of imaging algorithms to unravel the complex anatomy of the breast and its mechanical properties. The solution most commonly relied upon is time-of-flight tomography, but this exhibits low resolution due to the presence of diffraction effects. Iterative full-wave inversion methods present one solution to achieve higher resolution, but these are slow and are not guaranteed to converge to the correct solution. Presented here is HARBUT, the hybrid algorithm for robust breast ultrasound tomography, which utilizes the complementary strengths of time-of-flight and diffraction tomography resulting in a direct, fast, robust and accurate high resolution method of reconstructing the sound speed through the breast. The algorithm is shown to produce accurate reconstructions with realistic data from a complex three-dimensional simulation, with masses as small as 4 mm being clearly visible. © 2011 Acoustical Society of America

  17. Fast and robust clinical triple-region image segmentation using one level set function.

    PubMed

    Li, Shuo; Fevens, Thomas; Krzyzak, Adam; Jin, Chao; Li, Song

    2006-01-01

    This paper proposes a novel method for clinical triple-region image segmentation using a single level set function. Triple-region image segmentation finds wide application in the computer aided X-ray, CT, MRI and ultrasound image analysis and diagnosis. Usually multiple level set functions are used consecutively or simultaneously to segment triple-region medical images. These approaches are either time consuming or suffer from the convergence problems. With the new proposed triple-regions level set energy modelling, the triple-region segmentation is handled within the two region level set framework where only one single level set function needed. Since only a single level set function is used, the segmentation is much faster and more robust than using multiple level set functions. Adapted to the clinical setting, individual principal component analysis and a support vector machine classifier based clinical acceleration scheme are used to accelerate the segmentation. The clinical acceleration scheme takes the strengths of both machine learning and the level set method while limiting their weaknesses to achieve automatic and fast clinical segmentation. Both synthesized and practical images are used to test the proposed method. These results show that the proposed method is able to successfully segment the triple-region using a single level set function. Also this segmentation is very robust to the placement of initial contour. While still quickly converging to the final image, with the clinical acceleration scheme, our proposed method can be used during pre-processing for automatic computer aided diagnosis and surgery.

  18. FATSLiM: a fast and robust software to analyze MD simulations of membranes.

    PubMed

    Buchoux, Sébastien

    2017-01-01

    When studying biological membranes, Molecular Dynamics (MD) simulations reveal to be quite complementary to experimental techniques. Because the simulated systems keep increasing both in size and complexity, the analysis of MD trajectories need to be computationally efficient while being robust enough to perform analysis on membranes that may be curved or deformed due to their size and/or protein-lipid interactions. This work presents a new software named FATSLiM ('Fast Analysis Toolbox for Simulations of Lipid Membranes') that can extract physical properties from MD simulations of membranes (with or without interacting proteins). Because it relies on the calculation of local normals, FATSLiM does not depend of the bilayer morphology and thus can handle with the same accuracy vesicles for instance. Thanks to an efficiency-driven development, it is also fast and consumes a rather low amount of memory. FATSLiM (http://fatslim.github.io) is a stand-alone software written in Python. Source code is released under the GNU GPLv3 and is freely available at https://github.com/FATSLiM/fatslim A complete online documentation including instructions for platform-independent installation is available at http://pythonhosted.org/fatslim CONTACT: sebastien.buchoux@u-picardie.frSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Fast and Robust Inversion of Earthquake Source Rupture Process with Applications to Earthquake Emergency Response

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Zhang, Y.

    2010-12-01

    A fast and robust technique for inversion of earthquake source rupture process was developed and applied to some of the recent significant earthquakes worldwide. Since May 2008, source rupture processes of about 20 significant earthquakes worldwide were inverted by using the newly developed technique and the inverted results were timely released on the website within 3 to 5 hours after the occurrence of the earthquakes. These earthquakes included the MW7.8 Wenchuan, Sichuan, earthquake of 12 May 2008, the MW 6.3 L’Aquila, Italy, earthquake of 6 April 2009, the MW 7.0 Haiti earthquake of 12 January 2010, the MW 8.8 Chile earthquake of 27 February, 2010, the MW 6.5 Jiaxian, Taiwan, earthquake of 4 March 2010, the MW7.2 Mexico earthquake of 4 April 2010, the MW7.8 Sumatra earthquake of 6 April 2010, and the MW6.9 Yushu, Qinghai, earthquake of 14 April 2010. It is found that in addition to the usual earthquake source parameters, the fast inverted results of the spatial-temporal rupture process of the earthquake sources provided important information such as the possible disastrous areas and the timely release of these results proved very useful to earthquake emergency response and seismic disaster relief efforts.

  20. How fast-growing bacteria robustly tune their ribosome concentration to approximate growth-rate maximization.

    PubMed

    Bosdriesz, Evert; Molenaar, Douwe; Teusink, Bas; Bruggeman, Frank J

    2015-05-01

    Maximization of growth rate is an important fitness strategy for bacteria. Bacteria can achieve this by expressing proteins at optimal concentrations, such that resources are not wasted. This is exemplified for Escherichia coli by the increase of its ribosomal protein-fraction with growth rate, which precisely matches the increased protein synthesis demand. These findings and others have led to the hypothesis that E. coli aims to maximize its growth rate in environments that support growth. However, what kind of regulatory strategy is required for a robust, optimal adjustment of the ribosome concentration to the prevailing condition is still an open question. In the present study, we analyze the ppGpp-controlled mechanism of ribosome expression used by E. coli and show that this mechanism maintains the ribosomes saturated with its substrates. In this manner, overexpression of the highly abundant ribosomal proteins is prevented, and limited resources can be redirected to the synthesis of other growth-promoting enzymes. It turns out that the kinetic conditions for robust, optimal protein-partitioning, which are required for growth rate maximization across conditions, can be achieved with basic biochemical interactions. We show that inactive ribosomes are the most suitable 'signal' for tracking the intracellular nutritional state and for adjusting gene expression accordingly, as small deviations from optimal ribosome concentration cause a huge fractional change in ribosome inactivity. We expect to find this control logic implemented across fast-growing microbial species because growth rate maximization is a common selective pressure, ribosomes are typically highly abundant and thus costly, and the required control can be implemented by a small, simple network.

  1. Fast and robust brain tumor segmentation using level set method with multiple image information.

    PubMed

    Lok, Ka Hei; Shi, Lin; Zhu, Xianlun; Wang, Defeng

    2017-01-01

    Brain tumor segmentation is a challenging task for its variation in intensity. The phenomenon is caused by the inhomogeneous content of tumor tissue and the choice of imaging modality. In 2010 Zhang developed the Selective Binary Gaussian Filtering Regularizing Level Set (SBGFRLS) model that combined the merits of edge-based and region-based segmentation. To improve the SBGFRLS method by modifying the singed pressure force (SPF) term with multiple image information and demonstrate effectiveness of proposed method on clinical images. In original SBGFRLS model, the contour evolution direction mainly depends on the SPF. By introducing a directional term in SPF, the metric could control the evolution direction. The SPF is altered by statistic values enclosed by the contour. This concept can be extended to jointly incorporate multiple image information. The new SPF term is expected to bring a solution for blur edge problem in brain tumor segmentation. The proposed method is validated with clinical images including pre- and post-contrast magnetic resonance images. The accuracy and robustness is compared with sensitivity, specificity, DICE similarity coefficient and Jaccard similarity index. Experimental results show improvement, in particular the increase of sensitivity at the same specificity, in segmenting all types of tumors except for the diffused tumor. The novel brain tumor segmentation method is clinical-oriented with fast, robust and accurate implementation and a minimal user interaction. The method effectively segmented homogeneously enhanced, non-enhanced, heterogeneously-enhanced, and ring-enhanced tumor under MR imaging. Though the method is limited by identifying edema and diffuse tumor, several possible solutions are suggested to turn the curve evolution into a fully functional clinical diagnosis tool.

  2. A fast, robust algorithm for power line interference cancellation in neural recording

    NASA Astrophysics Data System (ADS)

    Keshtkaran, Mohammad Reza; Yang, Zhi

    2014-04-01

    Objective. Power line interference may severely corrupt neural recordings at 50/60 Hz and harmonic frequencies. The interference is usually non-stationary and can vary in frequency, amplitude and phase. To retrieve the gamma-band oscillations at the contaminated frequencies, it is desired to remove the interference without compromising the actual neural signals at the interference frequency bands. In this paper, we present a robust and computationally efficient algorithm for removing power line interference from neural recordings. Approach. The algorithm includes four steps. First, an adaptive notch filter is used to estimate the fundamental frequency of the interference. Subsequently, based on the estimated frequency, harmonics are generated by using discrete-time oscillators, and then the amplitude and phase of each harmonic are estimated by using a modified recursive least squares algorithm. Finally, the estimated interference is subtracted from the recorded data. Main results. The algorithm does not require any reference signal, and can track the frequency, phase and amplitude of each harmonic. When benchmarked with other popular approaches, our algorithm performs better in terms of noise immunity, convergence speed and output signal-to-noise ratio (SNR). While minimally affecting the signal bands of interest, the algorithm consistently yields fast convergence (<100 ms) and substantial interference rejection (output SNR >30 dB) in different conditions of interference strengths (input SNR from -30 to 30 dB), power line frequencies (45-65 Hz) and phase and amplitude drifts. In addition, the algorithm features a straightforward parameter adjustment since the parameters are independent of the input SNR, input signal power and the sampling rate. A hardware prototype was fabricated in a 65 nm CMOS process and tested. Software implementation of the algorithm has been made available for open access at https://github.com/mrezak/removePLI. Significance. The proposed

  3. Fast and Robust Real-Time Estimation of Respiratory Rate from Photoplethysmography.

    PubMed

    Kim, Hodam; Kim, Jeong-Youn; Im, Chang-Hwan

    2016-09-14

    Respiratory rate (RR) is a useful vital sign that can not only provide auxiliary information on physiological changes within the human body, but also indicate early symptoms of various diseases. Recently, methods for the estimation of RR from photoplethysmography (PPG) have attracted increased interest, because PPG can be readily recorded using wearable sensors such as smart watches and smart bands. In the present study, we propose a new method for the fast and robust real-time estimation of RR using an adaptive infinite impulse response (IIR) notch filter, which has not yet been applied to the PPG-based estimation of RR. In our offline simulation study, the performance of the proposed method was compared to that of recently developed RR estimation methods called an adaptive lattice-type RR estimator and a Smart Fusion. The results of the simulation study show that the proposed method could not only estimate RR more quickly and more accurately than the conventional methods, but also is most suitable for online RR monitoring systems, as it does not use any overlapping moving windows that require increased computational costs. In order to demonstrate the practical applicability of the proposed method, an online RR estimation system was implemented.

  4. Fast and robust method to compute colon centerline in CT colonography

    NASA Astrophysics Data System (ADS)

    Frimmel, Hans; Naeppi, Janne J.; Yoshida, Hiroyuki

    2003-05-01

    We developed a method for generating the centerline of a colon in CT Colonography that is computationally fast, and robust to collapsed regions. Patients underwent CT Colonography after standard pre-colonoscopy cleansing. The colonic lumen was segmented using an existing anatomy-based approach, and a distance map of the colonic lumen was computed using a distance transform. The centerline was computed as follows: Local maxima representative for the centerline were sparsely extracted from the distance map. Iteratively, each pair of maxima satisfying a set of connection criteria were connected, creating a graph-like structure containing a main centerline with additional branches. Branches were later removed and the resulting centerline was stored. Centerlines of the colon were computed, and also manually and independently drawn by two radiologists, for 33 CT Colonographic data sets. The data sets were chosen to give a wide spectrum of colons, ranging from cases with good segmentation and extension to cases with collapsed regions and numerous extra-colonic components such as small bowel. On average, 94% of the human-generated centerlines were correctly identified by the computer-generated centerlines. The average displacement between the human- and computer-generated centerlines was 4.0 mm. Average centerline computation time was less than 4 seconds.

  5. Definition of a Robust Supervisory Control Scheme for Sodium-Cooled Fast Reactors

    SciTech Connect

    Ponciroli, Roberto; Passerini, Stefano; Vilim, Richard B.

    2016-01-01

    In this work, an innovative control approach for metal-fueled Sodium-cooled Fast Reactors is proposed. With respect to the classical approach adopted for base-load Nuclear Power Plants, an alternative control strategy for operating the reactor at different power levels by respecting the system physical constraints is presented. In order to achieve a higher operational flexibility along with ensuring that the implemented control loops do not influence the system inherent passive safety features, a dedicated supervisory control scheme for the dynamic definition of the corresponding set-points to be supplied to the PID controllers is designed. In particular, the traditional approach based on the adoption of tabulated lookup tables for the set-point definition is found not to be robust enough when failures of the implemented SISO (Single Input Single Output) actuators occur. Therefore, a feedback algorithm based on the Reference Governor approach, which allows for the optimization of reference signals according to the system operating conditions, is proposed.

  6. A fast-twitch oxidative-glycolytic muscle with a robust inward calcium current.

    PubMed

    Carlsen, R C; Larson, D B; Walsh, D A

    1985-08-01

    This report describes the histochemical and physiological properties of a rat skeletal muscle with a robust activity-dependent slow inward Ca2+ current. The muscle, the flexor digitorum brevis (FDB), is a small plantar flexor from the hindfoot. It is a homogeneous muscle consisting of approximately 90% fast-twitch oxidative-glycolytic (type IIA) fibers. Stimulation of the FDB with repetitive stimulus trains (30 or 50 Hz for 330 ms, 1 train/s for 2-5 min) produced a slow increase in the base-line or resting tension of the muscle between trains. This progressive increase in resting tension appears to be due to the activation of voltage-dependent slow Ca2+ channels, since it could be eliminated (i) by stimulating the muscle in a medium containing 2 mM EGTA and without Ca2+, and (ii) by the addition of either Co2+ or verapamil. The presence of a slow current may be associated with an increase in K+ efflux as stimulation continues, and with a prolongation of relaxation time. We also propose that the slow Ca2+ current may contribute to the allosteric activation of phosphorylase kinase during muscle activity. The FDB provides an excellent preparation to investigate the regulation of muscle metabolism by intra- and extra-cellular Ca2+ during exercise.

  7. Fast and robust 3D ultrasound registration--block and game theoretic matching.

    PubMed

    Banerjee, Jyotirmoy; Klink, Camiel; Peters, Edward D; Niessen, Wiro J; Moelker, Adriaan; van Walsum, Theo

    2015-02-01

    Real-time 3D US has potential for image guidance in minimally invasive liver interventions. However, motion caused by patient breathing makes it hard to visualize a localized area, and to maintain alignment with pre-operative information. In this work we develop a fast affine registration framework to compensate in real-time for liver motion/displacement due to breathing. The affine registration of two consecutive ultrasound volumes in time is performed using block-matching. For a set of evenly distributed points in one volume and their correspondences in the other volume, we propose a robust outlier rejection method to reject false matches. The inliers are then used to determine the affine transformation. The approach is evaluated on 13 4D ultrasound sequences acquired from 8 subjects. For 91 pairs of 3D ultrasound volumes selected from these sequences, a mean registration error of 1.8mm is achieved. A graphics processing unit (GPU) implementation runs the 3D US registration at 8 Hz.

  8. Definition of a Robust Supervisory Control Scheme for Sodium-Cooled Fast Reactors

    SciTech Connect

    Ponciroli, R.; Passerini, S.; Vilim, R. B.

    2016-04-17

    In this work, an innovative control approach for metal-fueled Sodium-cooled Fast Reactors is proposed. With respect to the classical approach adopted for base-load Nuclear Power Plants, an alternative control strategy for operating the reactor at different power levels by respecting the system physical constraints is presented. In order to achieve a higher operational flexibility along with ensuring that the implemented control loops do not influence the system inherent passive safety features, a dedicated supervisory control scheme for the dynamic definition of the corresponding set-points to be supplied to the PID controllers is designed. In particular, the traditional approach based on the adoption of tabulated lookup tables for the set-point definition is found not to be robust enough when failures of the implemented SISO (Single Input Single Output) actuators occur. Therefore, a feedback algorithm based on the Reference Governor approach, which allows for the optimization of reference signals according to the system operating conditions, is proposed.

  9. Robust alignment of chromatograms by statistically analyzing the shifts matrix generated by moving window fast Fourier transform cross-correlation.

    PubMed

    Zhang, Mingjing; Wen, Ming; Zhang, Zhi-Min; Lu, Hongmei; Liang, Yizeng; Zhan, Dejian

    2015-03-01

    Retention time shift is one of the most challenging problems during the preprocessing of massive chromatographic datasets. Here, an improved version of the moving window fast Fourier transform cross-correlation algorithm is presented to perform nonlinear and robust alignment of chromatograms by analyzing the shifts matrix generated by moving window procedure. The shifts matrix in retention time can be estimated by fast Fourier transform cross-correlation with a moving window procedure. The refined shift of each scan point can be obtained by calculating the mode of corresponding column of the shifts matrix. This version is simple, but more effective and robust than the previously published moving window fast Fourier transform cross-correlation method. It can handle nonlinear retention time shift robustly if proper window size has been selected. The window size is the only one parameter needed to adjust and optimize. The properties of the proposed method are investigated by comparison with the previous moving window fast Fourier transform cross-correlation and recursive alignment by fast Fourier transform using chromatographic datasets. The pattern recognition results of a gas chromatography mass spectrometry dataset of metabolic syndrome can be improved significantly after preprocessing by this method. Furthermore, the proposed method is available as an open source package at https://github.com/zmzhang/MWFFT2.

  10. Fast and robust-vanishing point detection system using fast M-estimation method and regional division for in-vehicle camera

    NASA Astrophysics Data System (ADS)

    Kondo, Y.; Numada, M.; Koshimizu, H.

    2017-03-01

    The vanishing point detection technology helps automatic driving. In this study, the straight lines on a road for the clue of the vanishing point are extracted efficiently by using the regional division and angle limitation. And, the vanishing point is detected robustly by using the fast M-estimation method. Proposed method could detect straight line ingredient tied to the vanishing point detection efficient on the road. And the vanishing point was detected exactly by the effect of the fast M-estimation method when the straight line ingredient which was not tied to the vanishing point detection was detected.

  11. WATSFAR: numerical simulation of soil WATer and Solute fluxes using a FAst and Robust method

    NASA Astrophysics Data System (ADS)

    Crevoisier, David; Voltz, Marc

    2013-04-01

    To simulate the evolution of hydro- and agro-systems, numerous spatialised models are based on a multi-local approach and improvement of simulation accuracy by data-assimilation techniques are now used in many application field. The latest acquisition techniques provide a large amount of experimental data, which increase the efficiency of parameters estimation and inverse modelling approaches. In turn simulations are often run on large temporal and spatial domains which requires a large number of model runs. Eventually, despite the regular increase in computing capacities, the development of fast and robust methods describing the evolution of saturated-unsaturated soil water and solute fluxes is still a challenge. Ross (2003, Agron J; 95:1352-1361) proposed a method, solving 1D Richards' and convection-diffusion equation, that fulfil these characteristics. The method is based on a non iterative approach which reduces the numerical divergence risks and allows the use of coarser spatial and temporal discretisations, while assuring a satisfying accuracy of the results. Crevoisier et al. (2009, Adv Wat Res; 32:936-947) proposed some technical improvements and validated this method on a wider range of agro- pedo- climatic situations. In this poster, we present the simulation code WATSFAR which generalises the Ross method to other mathematical representations of soil water retention curve (i.e. standard and modified van Genuchten model) and includes a dual permeability context (preferential fluxes) for both water and solute transfers. The situations tested are those known to be the less favourable when using standard numerical methods: fine textured and extremely dry soils, intense rainfall and solute fluxes, soils near saturation, ... The results of WATSFAR have been compared with the standard finite element model Hydrus. The analysis of these comparisons highlights two main advantages for WATSFAR, i) robustness: even on fine textured soil or high water and solute

  12. A Fast and Robust Poisson-Boltzmann Solver Based on Adaptive Cartesian Grids.

    PubMed

    Boschitsch, Alexander H; Fenley, Marcia O

    2011-05-10

    An adaptive Cartesian grid (ACG) concept is presented for the fast and robust numerical solution of the 3D Poisson-Boltzmann Equation (PBE) governing the electrostatic interactions of large-scale biomolecules and highly charged multi-biomolecular assemblies such as ribosomes and viruses. The ACG offers numerous advantages over competing grid topologies such as regular 3D lattices and unstructured grids. For very large biological molecules and multi-biomolecule assemblies, the total number of grid-points is several orders of magnitude less than that required in a conventional lattice grid used in the current PBE solvers thus allowing the end user to obtain accurate and stable nonlinear PBE solutions on a desktop computer. Compared to tetrahedral-based unstructured grids, ACG offers a simpler hierarchical grid structure, which is naturally suited to multigrid, relieves indirect addressing requirements and uses fewer neighboring nodes in the finite difference stencils. Construction of the ACG and determination of the dielectric/ionic maps are straightforward, fast and require minimal user intervention. Charge singularities are eliminated by reformulating the problem to produce the reaction field potential in the molecular interior and the total electrostatic potential in the exterior ionic solvent region. This approach minimizes grid-dependency and alleviates the need for fine grid spacing near atomic charge sites. The technical portion of this paper contains three parts. First, the ACG and its construction for general biomolecular geometries are described. Next, a discrete approximation to the PBE upon this mesh is derived. Finally, the overall solution procedure and multigrid implementation are summarized. Results obtained with the ACG-based PBE solver are presented for: (i) a low dielectric spherical cavity, containing interior point charges, embedded in a high dielectric ionic solvent - analytical solutions are available for this case, thus allowing rigorous

  13. A Fast and Robust Poisson-Boltzmann Solver Based on Adaptive Cartesian Grids

    PubMed Central

    Boschitsch, Alexander H.; Fenley, Marcia O.

    2011-01-01

    An adaptive Cartesian grid (ACG) concept is presented for the fast and robust numerical solution of the 3D Poisson-Boltzmann Equation (PBE) governing the electrostatic interactions of large-scale biomolecules and highly charged multi-biomolecular assemblies such as ribosomes and viruses. The ACG offers numerous advantages over competing grid topologies such as regular 3D lattices and unstructured grids. For very large biological molecules and multi-biomolecule assemblies, the total number of grid-points is several orders of magnitude less than that required in a conventional lattice grid used in the current PBE solvers thus allowing the end user to obtain accurate and stable nonlinear PBE solutions on a desktop computer. Compared to tetrahedral-based unstructured grids, ACG offers a simpler hierarchical grid structure, which is naturally suited to multigrid, relieves indirect addressing requirements and uses fewer neighboring nodes in the finite difference stencils. Construction of the ACG and determination of the dielectric/ionic maps are straightforward, fast and require minimal user intervention. Charge singularities are eliminated by reformulating the problem to produce the reaction field potential in the molecular interior and the total electrostatic potential in the exterior ionic solvent region. This approach minimizes grid-dependency and alleviates the need for fine grid spacing near atomic charge sites. The technical portion of this paper contains three parts. First, the ACG and its construction for general biomolecular geometries are described. Next, a discrete approximation to the PBE upon this mesh is derived. Finally, the overall solution procedure and multigrid implementation are summarized. Results obtained with the ACG-based PBE solver are presented for: (i) a low dielectric spherical cavity, containing interior point charges, embedded in a high dielectric ionic solvent – analytical solutions are available for this case, thus allowing rigorous

  14. Robust and fast abdominal aortic aneurysm centerline detection for rupture risk prediction

    NASA Astrophysics Data System (ADS)

    Zhang, Hong; Finol, Ender A.

    2011-03-01

    This work describes a robust and fast semi-automatic approach for Abdominal Aortic Aneurysm (AAA) centerline detection. AAA is a vascular disease accompanied by progressive enlargement of the abdominal aorta, which leads to rupture if left untreated, an event that accounts for the 13th leading cause of death in the U.S. The lumen centerline can be used to provide the initial starting points for thrombus segmentation. Different from other methods, which are mostly based on region growing and suffer from problems of leakage and heavy computational burden, we propose a novel method based on online classification. An online version of the adaboost classifier based on steerable features is applied to AAA MRI data sets with a rectangular box enclosing the lumen in the first slice. The classifier is updated during the tracking process by using the testing result of the previous image as the new training data. Unlike traditional offline versions, the online classifier can adjust parameters automatically when a leakage occurs. With the help of integral images on the computation of haar-like features, the method can achieve nearly real time processing (about 2 seconds per image on a standard workstation). Ten ruptured and ten unruptured AAA data sets were processed and the tortuosity of the 20 centerlines was calculated. The correlation coefficient of the tortuosity was calculated to illustrate the significance of the prediction with the proposed method. The mean relative accuracy is 95.68% with a standard deviation of 0.89% when compared to a manual segmentation procedure. The correlation coefficient is 0.394.

  15. Robust digital image-in-image watermarking algorithm using the fast Hadamard transform

    NASA Astrophysics Data System (ADS)

    Ho, Anthony T. S.; Shen, Jun; Tan, Soon H.

    2003-01-01

    In this paper, we propose a robust image-in-image watermarking algorithm based on the fast Hadamard transform (FHT) for the copyright protection of digital images. Most current research makes use of a normally distributed random vector as a watermark and where the watermark can only be detected by cross-correlating the received coefficients with the watermark generated by secret key and then comparing an experimental threshold value. However, the FHT image-in-image method involves a "blind" watermarking process that retrieves the watermark without the need for an original image present. In the proposed approach, a number of pseudorandom selected 8×8 sub-blocks of original image and a watermark image are decomposed into Hadamard coefficients. To increase the invisibility of the watermark, a visual model based on original image characteristics, such as edges and textures are incorporated to determine the watermarking strength factor. All the AC Hadamard coefficients of watermark image is scaled by the watermarking strength factor and inserted into several middle and high frequency AC components of the Hadamard coefficients from the sub-blocks of original image. To further increase the reliability of the watermarking against the common geometric distortions, such as rotation and scaling, a post-processing technique is proposed. Understanding the type of distortion provides a mean to apply a reversal of the attack on the watermarked image, enabling the restoration to the synchronization of the embedding positions. The performance of the proposed algorithm is evaluated using Stirmark. The experiment uses container image of size 512×512×8bits and the watermark image of size 64×64×8bits. It survives about 60% of all Stirmark attacks. The simplicity of Hadamard transform offers a significant advantage in shorter processing time and ease of hardware implementation than the commonly used DCT and DWT techniques.

  16. F2DPR: a fast and robust cross-correlation technique for volumetric PIV

    NASA Astrophysics Data System (ADS)

    Earl, Thomas; Jeon, Young Jin; Lecordier, Bertrand; David, Laurent

    2016-08-01

    The current state-of-the-art in cross-correlation based time-resolved particle image velocimetry (PIV) techniques are the fluid trajectory correlation, FTC (Lynch and Scarano 2013) and the fluid trajectory evaluation based on an ensemble-averaged cross-correlation, FTEE (Jeon et al 2014a). These techniques compute the velocity vector as a polynomial trajectory Γ in space and time, enabling the extraction of beneficial quantities such as material acceleration whilst significantly increasing the accuracy of the particle displacement prediction achieved by standard two-frame PIV. In the context of time-resolved volumetric PIV, the drawback of trajectory computation is the computational expense of the three-dimensional (3D) cross-correlation, exacerbated by the requirement to perform N  -  1 cross-correlations, where N (for typically 5≤slant N≤slant 9 ) is the number of sequential particle volumes, for each velocity field. Therefore, the acceleration of this calculation is highly desirable. This paper re-examines the application of two-dimensional (2D) cross-correlation methods to three-dimensional (3D) datasets by Bilsky et al (2011) and the binning techniques of Discetti and Astarita (2012). A new and robust version of the 2D methods is proposed and described, called fast 2D projection—re-projection (f2dpr). Performance tests based on computational time and accuracy for both two-frame and multi-frame PIV are carried out on synthetically generated data. The cases presented herein include uniaxial uniform linear displacements and shear, and simulated turbulence data. The proposed algorithm is shown to be in the order of 10 times faster than a standard 3D FFT without loss of precision for a wide range of synthetic test cases, while combining with the binning technique can yield 50 times faster computation. The algorithm is also applied to reconstructed synthetic turbulent particle fields to investigate reconstruction noise on its performance and no

  17. Fast and robust multimodal image registration using a local derivative pattern.

    PubMed

    Jiang, Dongsheng; Shi, Yonghong; Chen, Xinrong; Wang, Manning; Song, Zhijian

    2017-02-01

    Deformable multimodal image registration, which can benefit radiotherapy and image guided surgery by providing complementary information, remains a challenging task in the medical image analysis field due to the difficulty of defining a proper similarity measure. This article presents a novel, robust and fast binary descriptor, the discriminative local derivative pattern (dLDP), which is able to encode images of different modalities into similar image representations. dLDP calculates a binary string for each voxel according to the pattern of intensity derivatives in its neighborhood. The descriptor similarity is evaluated using the Hamming distance, which can be efficiently computed, instead of conventional L1 or L2 norms. For the first time, we validated the effectiveness and feasibility of the local derivative pattern for multimodal deformable image registration with several multi-modal registration applications. dLDP was compared with three state-of-the-art methods in artificial image and clinical settings. In the experiments of deformable registration between different magnetic resonance imaging (MRI) modalities from BrainWeb, between computed tomography and MRI images from patient data, and between MRI and ultrasound images from BITE database, we show our method outperforms localized mutual information and entropy images in terms of both accuracy and time efficiency. We have further validated dLDP for the deformable registration of preoperative MRI and three-dimensional intraoperative ultrasound images. Our results indicate that dLDP reduces the average mean target registration error from 4.12 mm to 2.30 mm. This accuracy is statistically equivalent to the accuracy of the state-of-the-art methods in the study; however, in terms of computational complexity, our method significantly outperforms other methods and is even comparable to the sum of the absolute difference. The results reveal that dLDP can achieve superior performance regarding both accuracy and

  18. A fast-and-robust profiler for improving polymerase chain reaction diagnostics.

    PubMed

    Besseris, George J

    2014-01-01

    Polymerase chain reaction (PCR) is an in vitro technology in molecular genetics that progressively amplifies minimal copies of short DNA sequences in a fast and inexpensive manner. However, PCR performance is sensitive to suboptimal processing conditions. Compromised PCR conditions lead to artifacts and bias that downgrade the discriminatory power and reproducibility of the results. Promising attempts to resolve the PCR performance optimization issue have been guided by quality improvement tactics adopted in the past for industrial trials. Thus, orthogonal arrays (OAs) have been employed to program quick-and-easy structured experiments. Profiling of influences facilitates the quantification of effects that may counteract the detectability of amplified DNA fragments. Nevertheless, the attractive feature of reducing greatly the amount of work and expenditures by planning trials with saturated-unreplicated OA schemes is known to be relinquished in the subsequent analysis phase. This is because of an inherent incompatibility of ordinary multi-factorial comparison techniques to convert small yet dense datasets. Treating unreplicated-saturated data with either the analysis of variance (ANOVA) or regression models destroys the information extraction process. Both of those mentioned approaches are rendered blind to error since the examined effects absorb all available degrees of freedom. Therefore, in lack of approximating an experimental uncertainty, any outcome interpretation is rendered subjective. We propose a profiling method that permits the non-linear maximization of amplicon resolution by eliminating the necessity for direct error estimation. Our approach is distribution-free, calibration-free, simulation-free and sparsity-free with well-known power properties. It is also user-friendly by promoting rudimentary analytics. Testing our method on published amplicon count data, we found that the preponderant effect is the concentration of MgCl2 (p<0.05) followed by the

  19. Scatterometry—fast and robust measurements of nano-textured surfaces

    NASA Astrophysics Data System (ADS)

    Hannibal Madsen, Morten; Hansen, Poul-Erik

    2016-06-01

    Scatterometry is a fast, precise and low cost way to determine the mean pitch and dimensional parameters of periodic structures with lateral resolution of a few nanometer. It is robust enough for in-line process control and precise and accurate enough for metrology measurements. Furthermore, scatterometry is a non-destructive technique capable of measuring buried structures, for example a grating covered by a thick oxide layer. As scatterometry is a non-imaging technique, mathematical modeling is needed to retrieve structural parameters that describe a surface. In this review, the three main steps of scatterometry are discussed: the data acquisition, the simulation of diffraction efficiencies and the comparison of data and simulations. First, the intensity of the diffracted light is measured with a scatterometer as a function of incoming angle, diffraction angle and/or wavelength. We discuss the evolution of the scatterometers from the earliest angular scatterometers to the new imaging scatterometers. The basic principle of measuring diffraction efficiencies in scatterometry has remained the same since the beginning, but the instrumental improvements have made scatterometry a state-of-the-art solution for fast and accurate measurements of nano-textured surfaces. The improvements include extending the wavelength range from the visible to the extreme ultra-violet range, development of Fourier optics to measure all diffraction orders simultaneously, and an imaging scatterometer to measure area of interests smaller than the spot size. Secondly, computer simulations of the diffraction efficiencies are discussed with emphasis on the rigorous coupled-wave analysis (RCWA) method. RCWA has, since the mid-1990s, been the preferred method for grating simulations due to the speed of the algorithms. In the beginning the RCWA method suffered from a very slow convergence rate, and we discuss the historical improvements to overcome this challenge, e.g. by the introduction of Li

  20. MTC: A Fast and Robust Graph-Based Transductive Learning Method.

    PubMed

    Zhang, Yan-Ming; Huang, Kaizhu; Geng, Guang-Gang; Liu, Cheng-Lin

    2015-09-01

    Despite the great success of graph-based transductive learning methods, most of them have serious problems in scalability and robustness. In this paper, we propose an efficient and robust graph-based transductive classification method, called minimum tree cut (MTC), which is suitable for large-scale data. Motivated from the sparse representation of graph, we approximate a graph by a spanning tree. Exploiting the simple structure, we develop a linear-time algorithm to label the tree such that the cut size of the tree is minimized. This significantly improves graph-based methods, which typically have a polynomial time complexity. Moreover, we theoretically and empirically show that the performance of MTC is robust to the graph construction, overcoming another big problem of traditional graph-based methods. Extensive experiments on public data sets and applications on web-spam detection and interactive image segmentation demonstrate our method's advantages in aspect of accuracy, speed, and robustness.

  1. Fast and Robust Method for the Computation of Spherical Harmonic Coefficients from SST Data of GOCE Satellite

    NASA Astrophysics Data System (ADS)

    Touati, F.; Idres, M.; Kahlouche, S.

    2010-12-01

    A method is presented for the fast and robust computation of the spherical harmonic coefficients of the terrestrial gravitational field from precise kinematic orbit of GOCE satellite. To reduce the influence of outliers in the kinematic orbit, Huber's M-estimation is applied. The computational aspect of this method is studied with great importance by investigating the Newton's procedure which converges faster than the iteratively reweighted least squares (IRLS) algorithm. The processing strategy of the orbit data is based on satellite accelerations, which are derived from GPS position time-series by Newton's interpolation. The gradient of the gravitational potential with respect to rectangular coordinates is expressed using the Cunningham-Metris method. The Newton's law of motion performs the equality between satellite accelerations and the gradient of the gravitational potential in an inertial frame system. Numerical results using simulated data are realized in order to test the robustness and the computational efficiency of the proposed method.

  2. Highly robust hydrogels via a fast, simple and cytocompatible dual crosslinking-based process.

    PubMed

    Costa, Ana M S; Mano, João F

    2015-11-07

    A highly robust hydrogel device made from a single biopolymer formulation is reported. Owing to the presence of covalent and non-covalent crosslinks, these engineered systems were able to (i) sustain a compressive strength of ca. 20 MPa, (ii) quickly recover upon unloading, and (iii) encapsulate cells with high viability rates.

  3. A fast and robust level set method for image segmentation using fuzzy clustering and lattice Boltzmann method.

    PubMed

    Balla-Arabé, Souleymane; Gao, Xinbo; Wang, Bin

    2013-06-01

    In the last decades, due to the development of the parallel programming, the lattice Boltzmann method (LBM) has attracted much attention as a fast alternative approach for solving partial differential equations. In this paper, we first designed an energy functional based on the fuzzy c-means objective function which incorporates the bias field that accounts for the intensity inhomogeneity of the real-world image. Using the gradient descent method, we obtained the corresponding level set equation from which we deduce a fuzzy external force for the LBM solver based on the model by Zhao. The method is fast, robust against noise, independent to the position of the initial contour, effective in the presence of intensity inhomogeneity, highly parallelizable and can detect objects with or without edges. Experiments on medical and real-world images demonstrate the performance of the proposed method in terms of speed and efficiency.

  4. Transitionless-based shortcuts for the fast and robust generation of W states

    NASA Astrophysics Data System (ADS)

    Chen, Ye-Hong; Huang, Bi-Hua; Song, Jie; Xia, Yan

    2016-12-01

    We propose a scheme to generate W states based on transitionless-based shortcuts technique in cavity quantum electrodynamics (QED) system. In light of quantum Zeno dynamics, we first effectively design a system whose effective Hamiltonian is equivalent to the counter-diabatic driving Hamiltonian constructed by transitionless quantum driving, then, realize the W states' generation within this framework. For the sake of clearness, we describe two stale schemes for W states' generation via traditional methods: the adiabatic dark-state evolution and the quantum Zeno dynamics. The comparison among these three schemes shows the shortcut scheme is closely related to the other two but better than them. That is, numerical investigation demonstrates that the shortcut scheme is faster than the adiabatic one, and more robust against operational imperfection than the Zeno one. What is more, the present scheme is also robust against decoherence caused by spontaneous emission and photon loss.

  5. Fast and robust reconstruction for fluorescence molecular tomography via a sparsity adaptive subspace pursuit method.

    PubMed

    Ye, Jinzuo; Chi, Chongwei; Xue, Zhenwen; Wu, Ping; An, Yu; Xu, Han; Zhang, Shuang; Tian, Jie

    2014-02-01

    Fluorescence molecular tomography (FMT), as a promising imaging modality, can three-dimensionally locate the specific tumor position in small animals. However, it remains challenging for effective and robust reconstruction of fluorescent probe distribution in animals. In this paper, we present a novel method based on sparsity adaptive subspace pursuit (SASP) for FMT reconstruction. Some innovative strategies including subspace projection, the bottom-up sparsity adaptive approach, and backtracking technique are associated with the SASP method, which guarantees the accuracy, efficiency, and robustness for FMT reconstruction. Three numerical experiments based on a mouse-mimicking heterogeneous phantom have been performed to validate the feasibility of the SASP method. The results show that the proposed SASP method can achieve satisfactory source localization with a bias less than 1mm; the efficiency of the method is much faster than mainstream reconstruction methods; and this approach is robust even under quite ill-posed condition. Furthermore, we have applied this method to an in vivo mouse model, and the results demonstrate the feasibility of the practical FMT application with the SASP method.

  6. Untargeted metabolomics approach for unraveling robust biomarkers of nutritional status in fasted gilthead sea bream (Sparus aurata)

    PubMed Central

    Gil-Solsona, Ruben; Nácher-Mestre, Jaime; Lacalle-Bergeron, Leticia; Calduch-Giner, Josep Alvar; Hernández, Félix

    2017-01-01

    A metabolomic study has been performed to identify sensitive and robust biomarkers of malnutrition in farmed fish, using gilthead sea bream (Sparus aurata) as a model. The metabolomic fingerprinting of serum from fasted fish was assessed by means of ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. More than 15,000 different m/z ions were detected and Partial Least Squares–Discriminant analysis allowed a clear differentiation between the two experimental groups (fed and 10-day fasted fish) with more than 90% of total variance explained by the two first components. The most significant metabolites (up to 45) were elucidated on the basis of their tandem mass spectra with a broad representation of amino acids, oligopeptides, urea cycle metabolites, L-carnitine-related metabolites, glutathione-related metabolites, fatty acids, lysophosphatidic acids, phosphatidylcholines as well as biotin- and noradrenaline-related metabolites. This untargeted approach highlighted important adaptive responses in energy and oxidative metabolism, contributing to identify robust and nutritionally-regulated biomarkers of health and metabolic condition that will serve to assess the welfare status of farmed fish. PMID:28168106

  7. A Robust and Fast Method for Sidescan Sonar Image Segmentation Using Nonlocal Despeckling and Active Contour Model.

    PubMed

    Huo, Guanying; Yang, Simon X; Li, Qingwu; Zhou, Yan

    2017-04-01

    Sidescan sonar image segmentation is a very important issue in underwater object detection and recognition. In this paper, a robust and fast method for sidescan sonar image segmentation is proposed, which deals with both speckle noise and intensity inhomogeneity that may cause considerable difficulties in image segmentation. The proposed method integrates the nonlocal means-based speckle filtering (NLMSF), coarse segmentation using k -means clustering, and fine segmentation using an improved region-scalable fitting (RSF) model. The NLMSF is used before the segmentation to effectively remove speckle noise while preserving meaningful details such as edges and fine features, which can make the segmentation easier and more accurate. After despeckling, a coarse segmentation is obtained by using k -means clustering, which can reduce the number of iterations. In the fine segmentation, to better deal with possible intensity inhomogeneity, an edge-driven constraint is combined with the RSF model, which can not only accelerate the convergence speed but also avoid trapping into local minima. The proposed method has been successfully applied to both noisy and inhomogeneous sonar images. Experimental and comparative results on real and synthetic sonar images demonstrate that the proposed method is robust against noise and intensity inhomogeneity, and is also fast and accurate.

  8. Realising social justice in public health law.

    PubMed

    Fox, Marie; Thomson, Michael

    2013-03-01

    Law has played an important, but largely constitutive, role in the development of the public health enterprise. Thus, law has been central to setting up the institutions and offices of public health. The moral agenda has, however, been shaped to a much greater extent by bioethics. While social justice has been placed at the heart of this agenda, we argue that there has been little place within dominant conceptions of social justice for gender equity and women's interests which we see as crucial to a fully realised vision of social justice. We argue that, aside from particular interventions in the field of reproduction, public health practice tends to marginalise women-a claim we support by critically examining strategies to combat the HIV pandemic in sub-Saharan Africa. To counter the marginalisation of women's interests, this article argues that Amartya Sen's capabilities approach has much to contribute to the framing of public health law and policy. Sen's approach provides an evaluative and normative framework which recognises the importance of both gender and health equity to achieving social justice. We suggest that domestic law and international human rights provisions, in particular the emerging human right to health, offer mechanisms to promote capabilities, and foster a robust and inclusive conception of social justice.

  9. Neutral face classification using personalized appearance models for fast and robust emotion detection.

    PubMed

    Chiranjeevi, Pojala; Gopalakrishnan, Viswanath; Moogi, Pratibha

    2015-09-01

    Facial expression recognition is one of the open problems in computer vision. Robust neutral face recognition in real time is a major challenge for various supervised learning-based facial expression recognition methods. This is due to the fact that supervised methods cannot accommodate all appearance variability across the faces with respect to race, pose, lighting, facial biases, and so on, in the limited amount of training data. Moreover, processing each and every frame to classify emotions is not required, as user stays neutral for majority of the time in usual applications like video chat or photo album/web browsing. Detecting neutral state at an early stage, thereby bypassing those frames from emotion classification would save the computational power. In this paper, we propose a light-weight neutral versus emotion classification engine, which acts as a pre-processer to the traditional supervised emotion classification approaches. It dynamically learns neutral appearance at key emotion (KE) points using a statistical texture model, constructed by a set of reference neutral frames for each user. The proposed method is made robust to various types of user head motions by accounting for affine distortions based on a statistical texture model. Robustness to dynamic shift of KE points is achieved by evaluating the similarities on a subset of neighborhood patches around each KE point using the prior information regarding the directionality of specific facial action units acting on the respective KE point. The proposed method, as a result, improves emotion recognition (ER) accuracy and simultaneously reduces computational complexity of the ER system, as validated on multiple databases.

  10. Empirical approaches for fast robust inversion of seismic moment tensor from surface waves

    NASA Astrophysics Data System (ADS)

    Barriot, J.; Reymond, D.; Crusem, R.

    2009-12-01

    The generalized discrete inverse method of Tarantola-Valette is applied to the inversion of surface waves for obtaining the seismic moment tensor. Different criteria based on residuals and signal to noise ratio are re-injected in the covariance matrix at each step of the inversion process to perform a robust inversion (called also IRLS: Iterative Reweighted Least Square). The great advantages with the use of such techniques, is that aberrant data are automatically removed through the inversion process, without the necessity for careful human inspection and control of data quality.

  11. Fast Shear Compounding Using Robust Two-dimensional Shear Wave Speed Calculation and Multi-directional Filtering

    PubMed Central

    Song, Pengfei; Manduca, Armando; Zhao, Heng; Urban, Matthew W.; Greenleaf, James F.; Chen, Shigao

    2014-01-01

    A fast shear compounding method was developed in this study using only one shear wave push-detect cycle, such that the shear wave imaging frame rate is preserved and motion artifacts are minimized. The proposed method is composed of the following steps: 1. applying a comb-push to produce multiple differently angled shear waves at different spatial locations simultaneously; 2. decomposing the complex shear wave field into individual shear wave fields with differently oriented shear waves using a multi-directional filter; 3. using a robust two-dimensional (2D) shear wave speed calculation to reconstruct 2D shear elasticity maps from each filter direction; 4. compounding these 2D maps from different directions into a final map. An inclusion phantom study showed that the fast shear compounding method could achieve comparable performance to conventional shear compounding without sacrificing the imaging frame rate. A multi-inclusion phantom experiment showed that the fast shear compounding method could provide a full field-of-view (FOV), 2D, and compounded shear elasticity map with three types of inclusions clearly resolved and stiffness measurements showing excellent agreement to the nominal values. PMID:24613636

  12. Fast and robust control of nanopositioning systems: Performance limits enabled by field programmable analog arrays

    NASA Astrophysics Data System (ADS)

    Baranwal, Mayank; Gorugantu, Ram S.; Salapaka, Srinivasa M.

    2015-08-01

    This paper aims at control design and its implementation for robust high-bandwidth precision (nanoscale) positioning systems. Even though modern model-based control theoretic designs for robust broadband high-resolution positioning have enabled orders of magnitude improvement in performance over existing model independent designs, their scope is severely limited by the inefficacies of digital implementation of the control designs. High-order control laws that result from model-based designs typically have to be approximated with reduced-order systems to facilitate digital implementation. Digital systems, even those that have very high sampling frequencies, provide low effective control bandwidth when implementing high-order systems. In this context, field programmable analog arrays (FPAAs) provide a good alternative to the use of digital-logic based processors since they enable very high implementation speeds, moreover with cheaper resources. The superior flexibility of digital systems in terms of the implementable mathematical and logical functions does not give significant edge over FPAAs when implementing linear dynamic control laws. In this paper, we pose the control design objectives for positioning systems in different configurations as optimal control problems and demonstrate significant improvements in performance when the resulting control laws are applied using FPAAs as opposed to their digital counterparts. An improvement of over 200% in positioning bandwidth is achieved over an earlier digital signal processor (DSP) based implementation for the same system and same control design, even when for the DSP-based system, the sampling frequency is about 100 times the desired positioning bandwidth.

  13. Empirical approaches for fast robust inversion of seismic moment tensor from surface waves

    NASA Astrophysics Data System (ADS)

    Reymond, D.; Crusem, R.; Barriot, J. P.

    2010-04-01

    We present a method of robust inversion (also called IRLS: Iterative Reweighted Least Squares) which is surprisingly insensitive to outlier data points, as it discards automatically the aberrant points, without the necessity for careful human inspection and control of data quality. Different criteria based on residuals and signal-to-noise ratio are injected into the covariance matrix (acting like a weighting function), to perform the robust inversion using the iterative generalized discrete inverse method of Tarantola-Valette. From a practical point of view, this algorithm is used as the Preliminary Determination of Focal Mechanism (PDFM) method, which is a project for rapid estimation of source parameters of strong earthquakes in the context of tsunami warning. The input data to be inverted are spectra of long period surface waves, and as an output, the computed result is the seismic moment tensor, from which focal geometry of an earthquake, and principal stress axes are obtained. This method can be applied to any other method of non-linear (iterative) inversions confronted to the problem of outlier points polluting the data sets.

  14. Learning local appearances with sparse representation for robust and fast visual tracking.

    PubMed

    Bai, Tianxiang; Li, You-Fu; Zhou, Xiaolong

    2015-04-01

    In this paper, we present a novel appearance model using sparse representation and online dictionary learning techniques for visual tracking. In our approach, the visual appearance is represented by sparse representation, and the online dictionary learning strategy is used to adapt the appearance variations during tracking. We unify the sparse representation and online dictionary learning by defining a sparsity consistency constraint that facilitates the generative and discriminative capabilities of the appearance model. An elastic-net constraint is enforced during the dictionary learning stage to capture the characteristics of the local appearances that are insensitive to partial occlusions. Hence, the target appearance is effectively recovered from the corruptions using the sparse coefficients with respect to the learned sparse bases containing local appearances. In the proposed method, the dictionary is undercomplete and can thus be efficiently implemented for tracking. Moreover, we employ a median absolute deviation based robust similarity metric to eliminate the outliers and evaluate the likelihood between the observations and the model. Finally, we integrate the proposed appearance model with the particle filter framework to form a robust visual tracking algorithm. Experiments on benchmark video sequences show that the proposed appearance model outperforms the other state-of-the-art approaches in tracking performance.

  15. Development of Chemically and Thermally Robust Lithium Fast Ion Conducting Chalcogenide Glasses

    NASA Technical Reports Server (NTRS)

    Martin, Steve W.; Hagedorn, Norman (Technical Monitor)

    2002-01-01

    In this project, a new research thrust into the development of an entirely new class of FIC glasses has begun that may lead to a new set of optimized thin-film lithium ion conducting materials. New chemically robust FIC glasses are being prepared that are expected to exhibit unusually high chemical and electrochemical stability. New thermally robust FIC glasses are being prepared that exhibit softening points in excess of 500 C which will dramatically expand the usable operating temperature range of batteries, fuel-cells, and sensors using such electrolytes. Glasses are being explored in the general compositional series xLi2S+ yGa2S3 + (1-x-y)GeS2. Li2S is added as the source of the conductive lithium ions. GeS2 is the base glass-forming phase and the trivalent sulfides, Ga2S3, is added to increase the "refractoniness" of the glass, that is to significantly increase the softening point of the glass as well as its chemical stability. By optimizing the composition of the glass, new glasses and glass-ceramic FIC materials have been prepared with softening points in excess of 500 C and conductivities above 10(exp -3)/Ohm cm at room temperature. These latter attributes are currently not available in any FIC glasses to date.

  16. Fast and robust control of nanopositioning systems: Performance limits enabled by field programmable analog arrays.

    PubMed

    Baranwal, Mayank; Gorugantu, Ram S; Salapaka, Srinivasa M

    2015-08-01

    This paper aims at control design and its implementation for robust high-bandwidth precision (nanoscale) positioning systems. Even though modern model-based control theoretic designs for robust broadband high-resolution positioning have enabled orders of magnitude improvement in performance over existing model independent designs, their scope is severely limited by the inefficacies of digital implementation of the control designs. High-order control laws that result from model-based designs typically have to be approximated with reduced-order systems to facilitate digital implementation. Digital systems, even those that have very high sampling frequencies, provide low effective control bandwidth when implementing high-order systems. In this context, field programmable analog arrays (FPAAs) provide a good alternative to the use of digital-logic based processors since they enable very high implementation speeds, moreover with cheaper resources. The superior flexibility of digital systems in terms of the implementable mathematical and logical functions does not give significant edge over FPAAs when implementing linear dynamic control laws. In this paper, we pose the control design objectives for positioning systems in different configurations as optimal control problems and demonstrate significant improvements in performance when the resulting control laws are applied using FPAAs as opposed to their digital counterparts. An improvement of over 200% in positioning bandwidth is achieved over an earlier digital signal processor (DSP) based implementation for the same system and same control design, even when for the DSP-based system, the sampling frequency is about 100 times the desired positioning bandwidth.

  17. An accurate, fast and robust method to generate patient-specific cubic Hermite meshes.

    PubMed

    Lamata, Pablo; Niederer, Steven; Nordsletten, David; Barber, David C; Roy, Ishani; Hose, D Rod; Smith, Nic

    2011-12-01

    In-silico continuum simulations of organ and tissue scale physiology often require a discretisation or mesh of the solution domain. Cubic Hermite meshes provide a smooth representation of anatomy that is well-suited for simulating large deformation mechanics. Models of organ mechanics and deformation have demonstrated significant potential for clinical application. However, the production of a personalised mesh from patient's anatomy using medical images remains a major bottleneck in simulation workflows. To address this issue, we have developed an accurate, fast and automatic method for deriving patient-specific cubic Hermite meshes. The proposed solution customises a predefined template with a fast binary image registration step and a novel cubic Hermite mesh warping constructed using a variational technique. Image registration is used to retrieve the mapping field between the template mesh and the patient images. The variational warping technique then finds a smooth and accurate projection of this field into the basis functions of the mesh. Applying this methodology, cubic Hermite meshes are fitted to the binary description of shape with sub-voxel accuracy and within a few minutes, which is a significant advance over the existing state of the art methods. To demonstrate its clinical utility, a generic cubic Hermite heart biventricular model is personalised to the anatomy of four patients, and the resulting mechanical stability of these customised meshes is successfully demonstrated. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Optimal Control for Fast and Robust Generation of Entangled States in Anisotropic Heisenberg Chains

    NASA Astrophysics Data System (ADS)

    Zhang, Xiong-Peng; Shao, Bin; Zou, Jian

    2017-02-01

    Motivated by some recent results of the optimal control (OC) theory, we study anisotropic XXZ Heisenberg spin-1/2 chains with control fields acting on a single spin, with the aim of exploring how maximally entangled state can be prepared. To achieve the goal, we use a numerical optimization algorithm (e.g., the Krotov algorithm, which was shown to be capable of reaching the quantum speed limit) to search an optimal set of control parameters, and then obtain OC pulses corresponding to the target fidelity. We find that the minimum time for implementing our target state depending on the anisotropy parameter Δ of the model. Finally, we analyze the robustness of the obtained results for the optimal fidelities and the effectiveness of the Krotov method under some realistic conditions.

  19. Optimal Control for Fast and Robust Generation of Entangled States in Anisotropic Heisenberg Chains

    NASA Astrophysics Data System (ADS)

    Zhang, Xiong-Peng; Shao, Bin; Zou, Jian

    2017-05-01

    Motivated by some recent results of the optimal control (OC) theory, we study anisotropic XXZ Heisenberg spin-1/2 chains with control fields acting on a single spin, with the aim of exploring how maximally entangled state can be prepared. To achieve the goal, we use a numerical optimization algorithm (e.g., the Krotov algorithm, which was shown to be capable of reaching the quantum speed limit) to search an optimal set of control parameters, and then obtain OC pulses corresponding to the target fidelity. We find that the minimum time for implementing our target state depending on the anisotropy parameter Δ of the model. Finally, we analyze the robustness of the obtained results for the optimal fidelities and the effectiveness of the Krotov method under some realistic conditions.

  20. A fast, simple and robust protocol for growing crystals in the lipidic cubic phase.

    PubMed

    Aherne, Margaret; Lyons, Joseph A; Caffrey, Martin

    2012-12-01

    A simple and inexpensive protocol for producing crystals in the sticky and viscous mesophase used for membrane protein crystallization by the in meso method is described. It provides crystals that appear within 15-30 min of setup at 293 K. The protocol gives the experimenter a convenient way of gaining familiarity and a level of comfort with the lipidic cubic mesophase, which can be daunting as a material when first encountered. Having used the protocol to produce crystals of the test protein, lysozyme, the experimenter can proceed with confidence to apply the method to more valuable membrane (and soluble) protein targets. The glass sandwich plates prepared using this robust protocol can further be used to practice harvesting and snap-cooling of in meso-grown crystals, to explore diffraction data collection with mesophase-embedded crystals, and for an assortment of quality control and calibration applications when used in combination with a crystallization robot.

  1. Robust and fast pedestrian detection method for far-infrared automotive driving assistance systems

    NASA Astrophysics Data System (ADS)

    Liu, Qiong; Zhuang, Jiajun; Ma, Jun

    2013-09-01

    Despite considerable effort has been contributed to night-time pedestrian detection for automotive driving assistance systems recent years, robust and real-time pedestrian detection is by no means a trivial task and is still underway due to the moving cameras, uncontrolled outdoor environments, wide range of possible pedestrian presentations and the stringent performance criteria for automotive applications. This paper presents an alternative night-time pedestrian detection method using monocular far-infrared (FIR) camera, which includes two modules (regions of interest (ROIs) generation and pedestrian recognition) in a cascade fashion. Pixel-gradient oriented vertical projection is first proposed to estimate the vertical image stripes that might contain pedestrians, and then local thresholding image segmentation is adopted to generate ROIs more accurately within the estimated vertical stripes. A novel descriptor called PEWHOG (pyramid entropy weighted histograms of oriented gradients) is proposed to represent FIR pedestrians in recognition module. Specifically, PEWHOG is used to capture both the local object shape described by the entropy weighted distribution of oriented gradient histograms and its pyramid spatial layout. Then PEWHOG is fed to a three-branch structured classifier using support vector machines (SVM) with histogram intersection kernel (HIK). An off-line training procedure combining both the bootstrapping and early-stopping strategy is introduced to generate a more robust classifier by exploiting hard negative samples iteratively. Finally, multi-frame validation is utilized to suppress some transient false positives. Experimental results on FIR video sequences from various scenarios demonstrate that the presented method is effective and promising.

  2. Evaluating the CDM-Robustness of the input buffer with very fast transmission line pulse

    NASA Astrophysics Data System (ADS)

    Kao, Tzu-Cheng; Lee, Jian-Hsing; Hung, Chung-Yu; Lien, Chen-Hsin; Su, Hung-Der

    2015-02-01

    In this paper, a scheme for how to utilize VFTLP (very fast transmission line pulse) data to design an input buffer circuit for CDM (charged-device model) ESD protection is reported. The impedance of the ESD device under VFTLP stress is nearly 120 Ω at the beginning of turn-on transient, and decreases with time toward 10 Ω prior to the voltage falling below 0 V. In this work, the fact that the dynamic-characteristic impedance of the ESD device under VFTLP testing is independent of the stress current is found. Since both VFTLP zapping and the CDM are nanosecond events, the dynamic-characteristic impedance of the ESD device can be used to evaluate the CDM threshold voltage of the input buffer based on the equivalent and simplified RLC circuit.

  3. Fast and robust segmentation of the striatum using deep convolutional neural networks.

    PubMed

    Choi, Hongyoon; Jin, Kyong Hwan

    2016-12-01

    Automated segmentation of brain structures is an important task in structural and functional image analysis. We developed a fast and accurate method for the striatum segmentation using deep convolutional neural networks (CNN). T1 magnetic resonance (MR) images were used for our CNN-based segmentation, which require neither image feature extraction nor nonlinear transformation. We employed two serial CNN, Global and Local CNN: The Global CNN determined approximate locations of the striatum. It performed a regression of input MR images fitted to smoothed segmentation maps of the striatum. From the output volume of Global CNN, cropped MR volumes which included the striatum were extracted. The cropped MR volumes and the output volumes of Global CNN were used for inputs of Local CNN. Local CNN predicted the accurate label of all voxels. Segmentation results were compared with a widely used segmentation method, FreeSurfer. Our method showed higher Dice Similarity Coefficient (DSC) (0.893±0.017 vs. 0.786±0.015) and precision score (0.905±0.018 vs. 0.690±0.022) than FreeSurfer-based striatum segmentation (p=0.06). Our approach was also tested using another independent dataset, which showed high DSC (0.826±0.038) comparable with that of FreeSurfer. Comparison with existing method Segmentation performance of our proposed method was comparable with that of FreeSurfer. The running time of our approach was approximately three seconds. We suggested a fast and accurate deep CNN-based segmentation for small brain structures which can be widely applied to brain image analysis. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Robustly decoding multiple-line-structured light in temporal Fourier domain for fast and accurate three-dimensional reconstruction

    NASA Astrophysics Data System (ADS)

    Bian, Haidong; Liu, Kai

    2016-09-01

    Compared with grayscale patterns in structured light illumination, line stripes, as one binary pattern, are attractive for being more conveniently decoded. However, traditional line scanning typically involves a single line shifting across objects to avoid spatial ambiguities possibly introduced by complex surface geometry of objects. We propose a multiple-line strategy for fast and accurate reconstructing of the three-dimensional surfaces of targets. First, we build a mathematical model for multiline scanning, and second, we derive phase computation from the model along time axis and resolve the issue of ambiguity naturally. Errors of the proposed method are theoretically analyzed, and it shows that the proposed method is immune to nonlinearity and is robust to uncertainty. Experimental results demonstrate that the proposed method is of advantages both in accuracy and time cost.

  5. Fast and robust ray casting algorithms for virtual X-ray imaging

    NASA Astrophysics Data System (ADS)

    Freud, N.; Duvauchelle, P.; Létang, J. M.; Babot, D.

    2006-07-01

    Deterministic calculations based on ray casting techniques are known as a powerful alternative to the Monte Carlo approach to simulate X- or γ-ray imaging modalities (e.g. digital radiography and computed tomography), whenever computation time is a critical issue. One of the key components, from the viewpoint of computing resource expense, is the algorithm which determines the path length travelled by each ray through complex 3D objects. This issue has given rise to intensive research in the field of 3D rendering (in the visible light domain) during the last decades. The present work proposes algorithmic solutions adapted from state-of-the-art computer graphics to carry out ray casting in X-ray imaging configurations. This work provides an algorithmic basis to simulate direct transmission of X-rays, as well as scattering and secondary emission of radiation. Emphasis is laid on the speed and robustness issues. Computation times are given in a typical case of radiography simulation.

  6. Simultaneous gates in frequency-crowded multilevel systems using fast, robust, analytic control shapes

    NASA Astrophysics Data System (ADS)

    Theis, L. S.; Motzoi, F.; Wilhelm, F. K.

    2016-01-01

    We present a few-parameter ansatz for pulses to implement a broad set of simultaneous single-qubit rotations in frequency-crowded multilevel systems. Specifically, we consider a system of two qutrits whose working and leakage transitions suffer from spectral crowding (detuned by δ ). In order to achieve precise controllability, we make use of two driving fields (each having two quadratures) at two different tones to simultaneously apply arbitrary combinations of rotations about axes in the X -Y plane to both qubits. Expanding the waveforms in terms of Hanning windows, we show how analytic pulses containing smooth and composite-pulse features can easily achieve gate errors less than 10-4 and considerably outperform known adiabatic techniques. Moreover, we find a generalization of the WAHWAH (Weak AnHarmonicity With Average Hamiltonian) method by Schutjens et al. [R. Schutjens, F. A. Dagga, D. J. Egger, and F. K. Wilhelm, Phys. Rev. A 88, 052330 (2013)], 10.1103/PhysRevA.88.052330 that allows precise separate single-qubit rotations for all gate times beyond a quantum speed limit. We find in all cases a quantum speed limit slightly below 2 π /δ for the gate time and show that our pulses are robust against variations in system parameters and filtering due to transfer functions, making them suitable for experimental implementations.

  7. A fast and Robust Algorithm for general inequality/equality constrained minimum time problems

    SciTech Connect

    Briessen, B.; Sadegh, N.

    1995-12-01

    This paper presents a new algorithm for solving general inequality/equality constrained minimum time problems. The algorithm`s solution time is linear in the number of Runge-Kutta steps and the number of parameters used to discretize the control input history. The method is being applied to a three link redundant robotic arm with torque bounds, joint angle bounds, and a specified tip path. It solves case after case within a graphical user interface in which the user chooses the initial joint angles and the tip path with a mouse. Solve times are from 30 to 120 seconds on a Hewlett Packard workstation. A zero torque history is always used in the initial guess, and the algorithm has never crashed, indicating its robustness. The algorithm solves for a feasible solution for large trajectory execution time t{sub f} and then reduces t{sub f} and then reduces t{sub f} by a small amount and re-solves. The fixed time re- solve uses a new method of finding a near-minimum-2-norm solution to a set of linear equations and inequalities that achieves quadratic convegence to a feasible solution of the full nonlinear problem.

  8. Fast robust non-sequential optical ray-tracing with implicit algebraic surfaces

    NASA Astrophysics Data System (ADS)

    Greynolds, Alan W.

    2015-09-01

    The fastest, most robust, general technique for non-sequentially ray-tracing a large class of imaging and non-imaging optical systems is by geometric modeling with algebraic (i.e. polynomial) implicit surfaces. The basic theory of these surfaces with special attention to optimizing their precise intersection with a ray (even at grazing incidence) is outlined for an admittedly limited software implementation. On a couple of "tame" examples, a 64-bit Windows 7 version is significantly faster than the fastest commercial design software (all multi-threaded). Non-sequential ray-surface interactions approaching 30M/sec are achieved on a 12-core 2.67 GHz Mac Pro desktop computer. For a more exotic example of a 6th degree Wood's horn beam dump (light trap), a 32-bit Windows single thread version traces rays nearly 4 times faster than the commercial ASAP software's implicit algebraic surface and over 13 times faster than its equivalent NURBS surface. However, implicit surfaces are foreign to most CAD systems and thus unfortunately, don't easily fit into a modern workflow.

  9. A fast and robust iris localization method based on texture segmentation

    NASA Astrophysics Data System (ADS)

    Cui, Jiali; Wang, Yunhong; Tan, Tieniu; Ma, Li; Sun, Zhenan

    2004-08-01

    With the development of the current networked society, personal identification based on biometrics has received more and more attention. Iris recognition has a satisfying performance due to its high reliability and non-invasion. In an iris recognition system, preprocessing, especially iris localization plays a very important role. The speed and performance of an iris recognition system is crucial and it is limited by the results of iris localization to a great extent. Iris localization includes finding the iris boundaries (inner and outer) and the eyelids (lower and upper). In this paper, we propose an iris localization algorithm based on texture segmentation. First, we use the information of low frequency of wavelet transform of the iris image for pupil segmentation and localize the iris with a differential integral operator. Then the upper eyelid edge is detected after eyelash is segmented. Finally, the lower eyelid is localized using parabolic curve fitting based on gray value segmentation. Extensive experimental results show that the algorithm has satisfying performance and good robustness.

  10. HIFI-C: a robust and fast method for determining NMR couplings from adaptive 3D to 2D projections.

    PubMed

    Cornilescu, Gabriel; Bahrami, Arash; Tonelli, Marco; Markley, John L; Eghbalnia, Hamid R

    2007-08-01

    We describe a novel method for the robust, rapid, and reliable determination of J couplings in multi-dimensional NMR coupling data, including small couplings from larger proteins. The method, "High-resolution Iterative Frequency Identification of Couplings" (HIFI-C) is an extension of the adaptive and intelligent data collection approach introduced earlier in HIFI-NMR. HIFI-C collects one or more optimally tilted two-dimensional (2D) planes of a 3D experiment, identifies peaks, and determines couplings with high resolution and precision. The HIFI-C approach, demonstrated here for the 3D quantitative J method, offers vital features that advance the goal of rapid and robust collection of NMR coupling data. (1) Tilted plane residual dipolar couplings (RDC) data are collected adaptively in order to offer an intelligent trade off between data collection time and accuracy. (2) Data from independent planes can provide a statistical measure of reliability for each measured coupling. (3) Fast data collection enables measurements in cases where sample stability is a limiting factor (for example in the presence of an orienting medium required for residual dipolar coupling measurements). (4) For samples that are stable, or in experiments involving relatively stronger couplings, robust data collection enables more reliable determinations of couplings in shorter time, particularly for larger biomolecules. As a proof of principle, we have applied the HIFI-C approach to the 3D quantitative J experiment to determine N-C' RDC values for three proteins ranging from 56 to 159 residues (including a homodimer with 111 residues in each subunit). A number of factors influence the robustness and speed of data collection. These factors include the size of the protein, the experimental set up, and the coupling being measured, among others. To exhibit a lower bound on robustness and the potential for time saving, the measurement of dipolar couplings for the N-C' vector represents a realistic

  11. Development of a fast high performance liquid chromatographic screening system for eight antidiabetic drugs by an improved methodology of in-silico robustness simulation.

    PubMed

    Mokhtar, Hatem I; Abdel-Salam, Randa A; Haddad, Ghada M

    2015-06-19

    Robustness of RP-HPLC methods is a crucial method quality attribute which has gained an increasing interest throughout the efforts to apply quality by design concepts in analytical methodology. Improvement to design space modeling approaches to represent method robustness was the goal of many previous works. Modeling of design spaces regarding to method robustness fulfils quality by design essence of ensuring method validity throughout the design space. The current work aimed to describe an improvement to robustness modeling of design spaces in context of RP-HPLC method development for screening of eight antidiabetic drugs. The described improvement consisted of in-silico simulation of practical robustness testing procedures thus had the advantage of modeling design spaces with higher confidence in estimated of method robustness. The proposed in-silico robustness test was performed as a full factorial design of simulated method conditions deliberate shifts for each predicted point in knowledge space with modeling error propagation. Design space was then calculated as zones exceeding a threshold probability to pass the simulated robustness testing. Potential design spaces were mapped for three different stationary phases as a function of gradient elution parameters, pH and ternary solvent ratio. A robust and fast separation for the eight compounds within less than 6 min was selected and confirmed through experimental robustness testing. The effectiveness of this approach regarding definition of design spaces with ensured robustness and desired objectives was demonstrated.

  12. A Fast and Robust UHPLC-MRM-MS Method to Characterize and Quantify Grape Skin Tannins after Chemical Depolymerization.

    PubMed

    Pinasseau, Lucie; Verbaere, Arnaud; Roques, Maryline; Meudec, Emmanuelle; Vallverdú-Queralt, Anna; Terrier, Nancy; Boulet, Jean-Claude; Cheynier, Véronique; Sommerer, Nicolas

    2016-10-21

    A rapid, sensitive, and selective analysis method using ultra high performance liquid chromatography coupled with triple-quadrupole mass spectrometry (UHPLC-QqQ-MS) has been developed for the characterization and quantification of grape skin flavan-3-ols after acid-catalysed depolymerization in the presence of phloroglucinol (phloroglucinolysis). The compound detection being based on specific MS transitions in Multiple Reaction Monitoring (MRM) mode, this fast gradient robust method allows analysis of constitutive units of grape skin proanthocyanidins, including some present in trace amounts, in a single injection, with a throughput of 6 samples per hour. This method was applied to a set of 214 grape skin samples from 107 different red and white grape cultivars grown under two conditions in the vineyard, irrigated or non-irrigated. The results of triplicate analyses confirmed the robustness of the method, which was thus proven to be suitable for high-throughput and large-scale metabolomics studies. Moreover, these preliminary results suggest that analysis of tannin composition is relevant to investigate the genetic bases of grape response to drought.

  13. Fast and robust extraction of centerlines in 3D tubular structures using a scattered-snakelet approach

    NASA Astrophysics Data System (ADS)

    Spuhler, Christoph; Harders, Matthias; Székely, Gábor

    2006-03-01

    We present a fast and robust approach for automatic centerline extraction of tubular structures. The underlying idea is to cut traditional snakes into a set of shorter, independent segments - so-called snakelets. Following the same variational principles, each snakelet acts locally and extracts a subpart of the overall structure. After a parallel optimization step, outliers are detected and the remaining segments then form an implicit centerline. No manual initialization of the snakelets is necessary, which represents one advantage of the method. Moreover, computational complexity does not directly depend on dataset size, but on the number of snake segments necessary to cover the structure of interest, resulting in short computation times. Lastly, the approach is robust even for very complex datasets such as the small intestine. Our approach was tested on several medical datasets (CT datasets of colon, small bowel, and blood vessels) and yielded smooth, connected centerlines with few or no branches. The computation time needed is less than a minute using standard computing hardware.

  14. A fast and robust protocol for metataxonomic analysis using RNAseq data.

    PubMed

    Cox, Jeremy W; Ballweg, Richard A; Taft, Diana H; Velayutham, Prakash; Haslam, David B; Porollo, Aleksey

    2017-01-19

    Metagenomics is a rapidly emerging field aimed to analyze microbial diversity and dynamics by studying the genomic content of the microbiota. Metataxonomics tools analyze high-throughput sequencing data, primarily from 16S rRNA gene sequencing and DNAseq, to identify microorganisms and viruses within a complex mixture. With the growing demand for analysis of the functional microbiome, metatranscriptome studies attract more interest. To make metatranscriptomic data sufficient for metataxonomics, new analytical workflows are needed to deal with sparse and taxonomically less informative sequencing data. We present a new protocol, IMSA+A, for accurate taxonomy classification based on metatranscriptome data of any read length that can efficiently and robustly identify bacteria, fungi, and viruses in the same sample. The new protocol improves accuracy by using a conservative reference database, employing a new counting scheme, and by assembling shotgun reads. Assembly also reduces analysis runtime. Simulated data were utilized to evaluate the protocol by permuting common experimental variables. When applied to the real metatranscriptome data for mouse intestines colonized by ASF, the protocol showed superior performance in detection of the microorganisms compared to the existing metataxonomics tools. IMSA+A is available at https://github.com/JeremyCoxBMI/IMSA-A . The developed protocol addresses the need for taxonomy classification from RNAseq data. Previously not utilized, i.e., unmapped to a reference genome, RNAseq reads can now be used to gather taxonomic information about the microbiota present in a biological sample without conducting additional sequencing. Any metatranscriptome pipeline that includes assembly of reads can add this analysis with minimal additional cost of compute time. The new protocol also creates an opportunity to revisit old metatranscriptome data, where taxonomic content may be important but was not analyzed.

  15. Fast and robust Matlab-based finite element model used in the layup optimization of composite laminates

    NASA Astrophysics Data System (ADS)

    Şerban, A.

    2016-08-01

    The layup optimization of the laminated composites is a very complex topic which involves a convoluted solution space usually explored using heuristic computational techniques. Due to the solution space complexity a lot of layup configurations are evaluated during the optimization process. This fact leads to the mandatory requirement that the configuration evaluation should be fast enough to ensure the convergence of the optimization procedure without sacrificing the accuracy. In this work, we propose a robust, accurate and very fast finite element model based on the first-order shear deformation theory (FSDT). The model is structured in three main parts: preprocessing, processing and post processing. The main strategy is to transfer as much as possible operations in the preprocessing phase which is executed only once and to subsequently reuse the results in the processing and post processing phases which are executed for each layup configuration. Using this strategy, the execution time of the processing and post processing phases is drastically reduced and almost consists of regenerating and solving the global linear system - more that 95%. The proposed procedure is relatively easy to implement in Matlab which holds a very powerful linear system solver for sparse matrices. Also, the accuracy of the model was demonstrated by comparison with Ansys and with some closed form solutions.

  16. The ITS-90 realisation. A survey

    SciTech Connect

    Crovini, L.; Steur, P.P.M.

    1994-12-31

    The present state of the realisation of the International Temperature scale of 1990 is illustrated using the results of a recent inquiry conducted by the Consultative Committee for Thermometry of the CIPM among a sample group of metrology laboratories.

  17. Piece-wise quadratic approximations of arbitrary error functions for fast and robust machine learning.

    PubMed

    Gorban, A N; Mirkes, E M; Zinovyev, A

    2016-12-01

    Most of machine learning approaches have stemmed from the application of minimizing the mean squared distance principle, based on the computationally efficient quadratic optimization methods. However, when faced with high-dimensional and noisy data, the quadratic error functionals demonstrated many weaknesses including high sensitivity to contaminating factors and dimensionality curse. Therefore, a lot of recent applications in machine learning exploited properties of non-quadratic error functionals based on L1 norm or even sub-linear potentials corresponding to quasinorms Lp (0fast convergence to the local or global error minimum. The theory of PQSQ potentials is based on the notion of the cone of minorant functions, and represents a natural approximation formalism based on the application of min-plus algebra. The approach can be applied in most of existing machine learning methods, including methods of data approximation and regularized and sparse regression, leading to the improvement in the computational cost/accuracy trade-off. We demonstrate that on synthetic and real-life datasets PQSQ-based machine learning methods achieve orders of magnitude faster computational performance than the corresponding state-of-the-art methods, having similar or better approximation accuracy. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. A fast and robust method to clone and functionally validate T-cell receptors.

    PubMed

    Birkholz, Katrin; Hofmann, Christian; Hoyer, Stefanie; Schulz, Birgit; Harrer, Thomas; Kämpgen, Eckhart; Schuler, Gerold; Dörrie, Jan; Schaft, Niels

    2009-07-31

    Sequencing, cloning and functional testing of T-cell-receptor (TCR) alpha- and beta-chains from T-cell clones is often required in immunotherapy and in immunological research. However, the determination of the TCR chains by a simple PCR is not possible, since, in contrast to the 3' constant domain and untranslated region (UTR), no conserved sequences are present in the 5' region. Furthermore, subsequent functional testing of cloned TCRs requires laborious cell culture experiments, often involving primary human material and time-consuming viral transduction strategies. Here we present a universal PCR-based protocol, adapted from the capswitch technology, that allows for amplification of the TCR alpha- and beta-chain mRNAs without knowledge of the TCR variable domain subtype by attaching a designed sequence to the mRNA's 5' end. Two different MelanA/HLA-A2-specific and one HIVgag/HLA-A2-specific TCR were cloned that way, and were functionally tested by a newly developed easy, fast, and low-cost method: we electroporated Jurkat T cells simultaneously with TCR-encoding RNA and an NFAT-reporter construct, and measured the activation status of the cells upon specific stimulation. The results of this assay correlated with the cytokine release, functional avidity, proliferative activity, and the ability to recognize MelanA/HLA-A2-presenting tumor cells of bulk T cells electroporated with RNA encoding the same TCR. Together these two protocols represent a rapid and low-cost tool for the identification and functional testing of TCRs of T-cell clones, which can then be applied in immunotherapy or immunological research.

  19. Analysis and Development of A Robust Fuel for Gas-Cooled Fast Reactors

    SciTech Connect

    Knight, Travis W

    2010-01-31

    The focus of this effort was on the development of an advanced fuel for gas-cooled fast reactor (GFR) applications. This composite design is based on carbide fuel kernels dispersed in a ZrC matrix. The choice of ZrC is based on its high temperature properties and good thermal conductivity and improved retention of fission products to temperatures beyond that of traditional SiC based coated particle fuels. A key component of this study was the development and understanding of advanced fabrication techniques for GFR fuels that have potential to reduce minor actinide (MA) losses during fabrication owing to their higher vapor pressures and greater volatility. The major accomplishments of this work were the study of combustion synthesis methods for fabrication of the ZrC matrix, fabrication of high density UC electrodes for use in the rotating electrode process, production of UC particles by rotating electrode method, integration of UC kernels in the ZrC matrix, and the full characterization of each component. Major accomplishments in the near-term have been the greater characterization of the UC kernels produced by the rotating electrode method and their condition following the integration in the composite (ZrC matrix) following the short time but high temperature combustion synthesis process. This work has generated four journal publications, one conference proceeding paper, and one additional journal paper submitted for publication (under review). The greater significance of the work can be understood in that it achieved an objective of the DOE Generation IV (GenIV) roadmap for GFR Fuel—namely the demonstration of a composite carbide fuel with 30% volume fuel. This near-term accomplishment is even more significant given the expected or possible time frame for implementation of the GFR in the years 2030 -2050 or beyond.

  20. Hypothesis testing at the extremes: fast and robust association for high-throughput data

    PubMed Central

    Zhou, Yi-Hui; Wright, Fred A.

    2015-01-01

    A number of biomedical problems require performing many hypothesis tests, with an attendant need to apply stringent thresholds. Often the data take the form of a series of predictor vectors, each of which must be compared with a single response vector, perhaps with nuisance covariates. Parametric tests of association are often used, but can result in inaccurate type I error at the extreme thresholds, even for large sample sizes. Furthermore, standard two-sided testing can reduce power compared with the doubled \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$p$\\end{document}-value, due to asymmetry in the null distribution. Exact (permutation) testing is attractive, but can be computationally intensive and cumbersome. We present an approximation to exact association tests of trend that is accurate and fast enough for standard use in high-throughput settings, and can easily provide standard two-sided or doubled \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$p$\\end{document}-values. The approach is shown to be equivalent under permutation to likelihood ratio tests for the most commonly used generalized linear models (GLMs). For linear regression, covariates are handled by working with covariate-residualized responses and predictors. For GLMs, stratified covariates can be handled in a manner similar to exact conditional testing. Simulations and examples illustrate the wide applicability of the approach. The accompanying mcc package is available on CRAN http://cran.r-project.org/web/packages/mcc/index.html. PMID:25792622

  1. Realising point of care testing

    NASA Astrophysics Data System (ADS)

    Braybrook, J.

    2009-07-01

    Efforts to move molecular diagnostic technologies out of a centralised lab setting and closer to the patient have proved problematic. Early diagnosis of disease is often dependent upon detection of trace amounts of a molecular marker in a complex background. This challenging analytical scenario is compounded when testing is done in rapid manner using miniaturized & portable instruments. Metrology will be fundamental to delivering high quality and reliable clinical data with measurable sensitivity & robustness. Quality of the sample, integrity of the analyser, and ease of use together with incorporation of appropriate QC standards and demonstration of "fitness for purpose" will be key challenges.

  2. An improved I-FAST system for the diagnosis of Alzheimer's disease from unprocessed electroencephalograms by using robust invariant features.

    PubMed

    Buscema, Massimo; Vernieri, Fabrizio; Massini, Giulia; Scrascia, Federica; Breda, Marco; Rossini, Paolo Maria; Grossi, Enzo

    2015-05-01

    This paper proposes a new, complex algorithm for the blind classification of the original electroencephalogram (EEG) tracing of each subject, without any preliminary pre-processing. The medical need in this field is to reach an early differential diagnosis between subjects affected by mild cognitive impairment (MCI), early Alzheimer's disease (AD) and the healthy elderly (CTR) using only the recording and the analysis of few minutes of their EEG. This study analyzed the EEGs of 272 subjects, recorded at Rome's Neurology Unit of the Policlinico Campus Bio-Medico. The EEG recordings were performed using 19 electrodes, in a 0.3-70Hz bandpass, positioned according to the International 10-20 System. Many powerful learning machines and algorithms have been proposed during the last 20 years to effectively resolve this complex problem, resulting in different and interesting outcomes. Among these algorithms, a new artificial adaptive system, named implicit function as squashing time (I-FAST), is able to diagnose, with high accuracy, a few minutes of the subject's EEG track; whether it manifests an AD, MCI or CTR condition. An updating of this system, carried out by adding a new algorithm, named multi scale ranked organizing maps (MS-ROM), to the I-FAST system, is presented, in order to classify with greater accuracy the unprocessed EEG's of AD, MCI and control subjects. The proposed system has been measured on three independent pattern recognition tasks from unprocessed EEG tracks of a sample of AD subjects, MCI subjects and CTR: (a) AD compared with CTR; (b) AD compared with MCI; (c) CTR compared with MCI. While the values of accuracy of the previous system in distinguishing between AD and MCI were around 92%, the new proposed system reaches values between 94% and 98%. Similarly, the overall accuracy with best artificial neural networks (ANNs) is 98.25% for the distinguishing between CTR and MCI. This new version of I-FAST makes different steps forward: (a) avoidance of

  3. A Robust and Fast Computation Touchless Palm Print Recognition System Using LHEAT and the IFkNCN Classifier

    PubMed Central

    Jaafar, Haryati; Ibrahim, Salwani; Ramli, Dzati Athiar

    2015-01-01

    Mobile implementation is a current trend in biometric design. This paper proposes a new approach to palm print recognition, in which smart phones are used to capture palm print images at a distance. A touchless system was developed because of public demand for privacy and sanitation. Robust hand tracking, image enhancement, and fast computation processing algorithms are required for effective touchless and mobile-based recognition. In this project, hand tracking and the region of interest (ROI) extraction method were discussed. A sliding neighborhood operation with local histogram equalization, followed by a local adaptive thresholding or LHEAT approach, was proposed in the image enhancement stage to manage low-quality palm print images. To accelerate the recognition process, a new classifier, improved fuzzy-based k nearest centroid neighbor (IFkNCN), was implemented. By removing outliers and reducing the amount of training data, this classifier exhibited faster computation. Our experimental results demonstrate that a touchless palm print system using LHEAT and IFkNCN achieves a promising recognition rate of 98.64%. PMID:26113861

  4. A Robust and Fast Computation Touchless Palm Print Recognition System Using LHEAT and the IFkNCN Classifier.

    PubMed

    Jaafar, Haryati; Ibrahim, Salwani; Ramli, Dzati Athiar

    2015-01-01

    Mobile implementation is a current trend in biometric design. This paper proposes a new approach to palm print recognition, in which smart phones are used to capture palm print images at a distance. A touchless system was developed because of public demand for privacy and sanitation. Robust hand tracking, image enhancement, and fast computation processing algorithms are required for effective touchless and mobile-based recognition. In this project, hand tracking and the region of interest (ROI) extraction method were discussed. A sliding neighborhood operation with local histogram equalization, followed by a local adaptive thresholding or LHEAT approach, was proposed in the image enhancement stage to manage low-quality palm print images. To accelerate the recognition process, a new classifier, improved fuzzy-based k nearest centroid neighbor (IFkNCN), was implemented. By removing outliers and reducing the amount of training data, this classifier exhibited faster computation. Our experimental results demonstrate that a touchless palm print system using LHEAT and IFkNCN achieves a promising recognition rate of 98.64%.

  5. A fast and robust solver for the scattering from a layered periodic structure containing multi-particle inclusions

    NASA Astrophysics Data System (ADS)

    Lai, Jun; Kobayashi, Motoki; Barnett, Alex

    2015-10-01

    We present a solver for plane wave scattering from a periodic dielectric grating with a large number M of inclusions lying in each period of its middle layer. Such composite material geometries have a growing role in modern photonic devices and solar cells. The high-order scheme is based on boundary integral equations, and achieves many digits of accuracy with ease. The usual way to periodize the integral equation-via the quasi-periodic Green's function-fails at Wood's anomalies. We instead use the free-space Green's kernel for the near field, add auxiliary basis functions for the far field, and enforce periodicity in an expanded linear system; this is robust for all parameters. Inverting the periodic and layer unknowns, we are left with a square linear system involving only the inclusion scattering coefficients. Preconditioning by the single-inclusion scattering matrix, this is solved iteratively in O (M) time using a fast matrix-vector product. Numerical experiments show that a diffraction grating containing M = 1000 inclusions per period can be solved to 9-digit accuracy in under 5 minutes on a laptop.

  6. A fast and robust method for moment tensor and depth determination of shallow seismic events in CTBT related studies.

    NASA Astrophysics Data System (ADS)

    Baker, Ben; Stachnik, Joshua; Rozhkov, Mikhail

    2017-04-01

    International Data Center is required to conduct expert technical analysis and special studies to improve event parameters and assist State Parties in identifying the source of specific event according to the protocol to the Protocol to the Comprehensive Nuclear Test Ban Treaty. Determination of seismic event source mechanism and its depth is closely related to these tasks. It is typically done through a strategic linearized inversion of the waveforms for a complete or subset of source parameters, or similarly defined grid search through precomputed Greens Functions created for particular source models. In this presentation we demonstrate preliminary results obtained with the latter approach from an improved software design. In this development we tried to be compliant with different modes of CTBT monitoring regime and cover wide range of source-receiver distances (regional to teleseismic), resolve shallow source depths, provide full moment tensor solution based on body and surface waves recordings, be fast to satisfy both on-demand studies and automatic processing and properly incorporate observed waveforms and any uncertainties a priori as well as accurately estimate posteriori uncertainties. Posterior distributions of moment tensor parameters show narrow peaks where a significant number of reliable surface wave observations are available. For earthquake examples, fault orientation (strike, dip, and rake) posterior distributions also provide results consistent with published catalogues. Inclusion of observations on horizontal components will provide further constraints. In addition, the calculation of teleseismic P wave Green's Functions are improved through prior analysis to determine an appropriate attenuation parameter for each source-receiver path. Implemented HDF5 based Green's Functions pre-packaging allows much greater flexibility in utilizing different software packages and methods for computation. Further additions will have the rapid use of Instaseis

  7. Realisation of a compact methane optical clock

    SciTech Connect

    Gubin, M A; Kireev, A N; Konyashchenko, A V; Kryukov, P G; Tausenev, A V; Tyurikov, D A; Shelkovnikov, A S

    2008-07-31

    A compact optical clock based on a double-mode He-Ne/CH{sub 4} optical frequency standard and a femtosecond Er{sup 3+} fibre laser is realised and its stability against a commercial hydrogen frequency standard is measured. (letters)

  8. Towards Self-Realisation: Exploring the Ecological Self for Education

    ERIC Educational Resources Information Center

    Wang, Chia-Ling

    2016-01-01

    This study examines the concepts of self-realisation and the ecological self in Arne Naess's ecosophy, which considers the manner in which human inherent potentialities are realised in educational practices. This article first elucidates the meaning of the concepts of self-realisation and the ecological self according to Naess's work. Second, the…

  9. Towards Self-Realisation: Exploring the Ecological Self for Education

    ERIC Educational Resources Information Center

    Wang, Chia-Ling

    2016-01-01

    This study examines the concepts of self-realisation and the ecological self in Arne Naess's ecosophy, which considers the manner in which human inherent potentialities are realised in educational practices. This article first elucidates the meaning of the concepts of self-realisation and the ecological self according to Naess's work. Second, the…

  10. Fast, robust and high-resolution glycosylation profiling of intact monoclonal IgG antibodies using nanoLC-chip-QTOF.

    PubMed

    Jacobs, Joannes F M; Wevers, Ron A; Lefeber, Dirk J; van Scherpenzeel, Monique

    2016-10-01

    Optimal glycosylation of immunoglobulins is essential in the generation of therapeutic biologicals with respect to efficacy, pharmacokinetics and immunogenic properties. This challenge in the field of biopharmaceuticals requires technologies for fast, robust and quantitative analysis of glycosylation. Current analyses of monoclonal antibody glycosylation are proteolysis-based mass spectrometry methods, which provide detailed structural information, but suffer a number of drawbacks such as lengthy sample preparation with the possibility to introduce artifacts. Here, we describe a fast, robust and high-resolution nanoLC-chip-QTOF method for quantitative analysis of intact monoclonal IgG glycosylation profiling. The method is able to detect hypoglycosylation, i.e. the lack of whole glycans, which is an important advantage over the well-established methods for free N-glycan or glycopeptide analysis. Moreover, the method is highly amenable to automation and because no digestion steps are involved, it provides direct relative quantitative information of both glycans on each IgG attachment site. We demonstrate that the ease and robustness make this technique ideally suited for quality control of the production process of mAb biopharmaceuticals, and provides new opportunities to study the clinical impact of mAb-glycosylation in patients with monoclonal gammopathies.

  11. Realising the Promise of Cancer Predisposition Genes

    PubMed Central

    Rahman, Nazneen

    2016-01-01

    Genes in which germline mutations confer high or moderate increased risks of cancer are called cancer predisposition genes (CPG). Over 100 CPGs have been identified providing important scientific insights in many areas, particularly mechanisms of cancer causation. Moreover, clinical utilisation of CPGs has had substantial impact in diagnosis, optimised management and prevention of cancer. The recent transformative advances in DNA sequencing bring the promise of many more CPG discoveries and greater, broader clinical applications. However, there is also considerable potential for incorrect inferences and inappropriate clinical applications. Realising the promise of cancer predisposition genes for science and medicine will thus require careful navigation. PMID:24429628

  12. Experiments for Realising Pragmatic Protective Measurements

    SciTech Connect

    Dass, N. D. Hari

    2011-09-23

    I shall describe Aharonov, Anandan and Vaidman's proposal for protective measurements and their claims of providing an ontological interpretation for a certain class of wavefunctions through this type of measurement. I shall then describe work done with Tabish Qureshi which dispels this myth. I will show how the AAV proposal may be useful in a pragmatic sense and provide a concrete experimental setup using cold atoms. In particular, I will discuss how techniques developed by the Schmiedmayer group in Vienna for single-particle-sensitive imaging of freely propagating cold atoms could be adopted for this purpose. I will conclude with a brief description of my work with Anirban Das on adiabatic interactions between spin-systems and a proposal for its experimental realisation.

  13. Experiments for Realising Pragmatic Protective Measurements

    NASA Astrophysics Data System (ADS)

    Dass, N. D. Hari

    2011-09-01

    I shall describe Aharonov, Anandan and Vaidman's [1] proposal for protective measurements and their claims of providing an ontological interpretation for a certain class of wavefunctions through this type of measurement. I shall then describe work done with Tabish Qureshi [2] which dispels this myth. I will show how the AAV proposal may be useful in a pragmatic sense and provide a concrete experimental setup using cold atoms [4]. In particular, I will discuss how techniques developed by the Schmiedmayer group in Vienna [9] for single-particle-sensitive imaging of freely propagating cold atoms could be adopted for this purpose. I will conclude with a brief description of my work with Anirban Das [5] on adiabatic interactions between spin-systems and a proposal for its experimental realisation.

  14. Stable LPV realisation of the Smith predictor

    NASA Astrophysics Data System (ADS)

    Blanchini, Franco; Casagrande, Daniele; Miani, Stefano; Viaro, Umberto

    2016-07-01

    The paper is concerned with the control of a linear plant with an output delay. As is known, when the plant parameters do not vary in time, the transfer function approach can be used to find a high-performing controller with the Smith-predictor structure. Such an approach in the domain of the Laplace transform is not directly applicable in the time-variant case. Nevertheless, it is shown that the transfer function of the Smith controller valid for constant values of the parameters can be realised in such a way that closed-loop stability, as well as point-wise optimal performance, is ensured also when the parameters vary with time. The suggested technique is applied to the control of a heat exchanger whose varying parameters include a measurement delay.

  15. Whole genome sequence analysis of the arctic-lineage strain responsible for distemper in Italian wolves and dogs through a fast and robust next generation sequencing protocol.

    PubMed

    Marcacci, Maurilia; Ancora, Massimo; Mangone, Iolanda; Teodori, Liana; Di Sabatino, Daria; De Massis, Fabrizio; Camma', Cesare; Savini, Giovanni; Lorusso, Alessio

    2014-06-01

    Dynamic surveillance and characterization of canine distemper virus (CDV) circulating strains are essential against possible vaccine breakthroughs events. This study describes the setup of a fast and robust next-generation sequencing (NGS) Ion PGM™ protocol that was used to obtain the complete genome sequence of a CDV isolate (CDV2784/2013). CDV2784/2013 is the prototype of CDV strains responsible for severe clinical distemper in dogs and wolves in Italy during 2013. CDV2784/2013 was isolated on cell culture and total RNA was used for NGS sample preparation. A total of 112.3 Mb of reads were assembled de novo using MIRA version 4.0rc4, which yielded a total number of 403 contigs with 12.1% coverage. The whole genome (15,690 bp) was recovered successfully and compared to those of existing CDV whole genomes. CDV2784/2013 was shown to have 92% nt identity with the Onderstepoort vaccine strain. This study describes for the first time a fast and robust Ion PGM™ platform-based whole genome amplification protocol for non-segmented negative stranded RNA viruses starting from total cell-purified RNA. Additionally, this is the first study reporting the whole genome analysis of an Arctic lineage strain that is known to circulate widely in Europe, Asia and USA.

  16. Fast and robust population transfer in two-level quantum systems with dephasing noise and/or systematic frequency errors

    NASA Astrophysics Data System (ADS)

    Lu, Xiao-Jing; Chen, Xi; Ruschhaupt, A.; Alonso, D.; Guérin, S.; Muga, J. G.

    2013-09-01

    We design, by invariant-based inverse engineering, driving fields that invert the population of a two-level atom in a given time, robustly with respect to dephasing noise and/or systematic frequency shifts. Without imposing constraints, optimal protocols are insensitive to the perturbations but need an infinite energy. For a constrained value of the Rabi frequency, a flat π pulse is the least sensitive protocol to phase noise but not to systematic frequency shifts, for which we describe and optimize a family of protocols.

  17. A fast, robust, and simple implicit method for adaptive time-stepping on adaptive mesh-refinement grids

    NASA Astrophysics Data System (ADS)

    Commerçon, B.; Debout, V.; Teyssier, R.

    2014-03-01

    Context. Implicit solvers present strong limitations when used on supercomputing facilities and in particular for adaptive mesh-refinement codes. Aims: We present a new method for implicit adaptive time-stepping on adaptive mesh-refinement grids. We implement it in the radiation-hydrodynamics solver we designed for the RAMSES code for astrophysical purposes and, more particularly, for protostellar collapse. Methods: We briefly recall the radiation-hydrodynamics equations and the adaptive time-stepping methodology used for hydrodynamical solvers. We then introduce the different types of boundary conditions (Dirichlet, Neumann, and Robin) that are used at the interface between levels and present our implementation of the new method in the RAMSES code. The method is tested against classical diffusion and radiation-hydrodynamics tests, after which we present an application for protostellar collapse. Results: We show that using Dirichlet boundary conditions at level interfaces is a good compromise between robustness and accuracy and that it can be used in structure formation calculations. The gain in computational time over our former unique time step method ranges from factors of 5 to 50 depending on the level of adaptive time-stepping and on the problem. We successfully compare the old and new methods for protostellar collapse calculations that involve highly non linear physics. Conclusions: We have developed a simple but robust method for adaptive time-stepping of implicit scheme on adaptive mesh-refinement grids. It can be applied to a wide variety of physical problems that involve diffusion processes.

  18. A fast and robust kinematic model for a 12 DoF hyper-redundant robot positioning: An optimization proposal

    NASA Astrophysics Data System (ADS)

    Lima, José; Pereira, Ana I.; Costa, Paulo; Pinto, Andry; Costa, Pedro

    2017-07-01

    This paper describes an optimization procedure for a robot with 12 degrees of freedom avoiding the inverse kinematics problem, which is a hard task for this type of robot manipulator. This robot can be used to pick and place tasks in complex designs. Combining an accurate and fast direct kinematics model with optimization strategies, it is possible to achieve the joints angles for a desired end-effector position and orientation. The optimization methods stretched simulated annealing algorithm and genetic algorithm were used. The solutions found were validated using data originated by a real and by a simulated robot formed by 12 servomotors with a gripper.

  19. Robust computational method for fast calculations of multicharged ions lineshapes affected by a low-frequency electrostatic plasma turbulence

    NASA Astrophysics Data System (ADS)

    Dalimier, E.; Oks, E.

    2017-01-01

    Transport phenomena in plasmas, such as, e.g., resistivity, can be affected by electrostatic turbulence that frequently occurs in various kinds of laboratory and astrophysical plasmas. Transport phenomena are affected most significantly by a low-frequency electrostatic turbulence—such as, e.g., ion acoustic waves, also known as ionic sound—causing anomalous resistivity. In this case, for computing profiles of spectral lines, emitted by plasma ions, by any appropriate code for diagnostic purposes, it is necessary to calculate the distribution of the total quasistatic field. For a practically important situation, where the average turbulent field is much greater than the characteristic ion microfield, we develop a robust computational method valid for any appropriate distribution of the ion microfield at a charged point. We show that the correction to the Rayleigh distribution of the turbulent field is controlled by the behavior of the ion microfield distribution at large fields—in distinction to the opposite (and therefore, erroneous) result in the literature. We also obtain a universal analytical expression for the correction to the Rayleigh distribution based on the asymptotic of the ion microfield distribution at large fields at a charged point. By comparison with various known distributions of the ion microfield, we show that our asymptotic formula has a sufficiently high accuracy. Also exact computations are used to verify the high accuracy of the method. This robust approximate, but accurate method yields faster computational results than the exact calculations and therefore should be important for practical situations requiring simultaneous computations of a large number of spectral lineshapes (e.g., for calculating opacities)—especially for laser-produced plasmas.

  20. Fast periodic presentation of natural images reveals a robust face-selective electrophysiological response in the human brain.

    PubMed

    Rossion, Bruno; Torfs, Katrien; Jacques, Corentin; Liu-Shuang, Joan

    2015-01-16

    We designed a fast periodic visual stimulation approach to identify an objective signature of face categorization incorporating both visual discrimination (from nonface objects) and generalization (across widely variable face exemplars). Scalp electroencephalographic (EEG) data were recorded in 12 human observers viewing natural images of objects at a rapid frequency of 5.88 images/s for 60 s. Natural images of faces were interleaved every five stimuli, i.e., at 1.18 Hz (5.88/5). Face categorization was indexed by a high signal-to-noise ratio response, specifically at an oddball face stimulation frequency of 1.18 Hz and its harmonics. This face-selective periodic EEG response was highly significant for every participant, even for a single 60-s sequence, and was generally localized over the right occipitotemporal cortex. The periodicity constraint and the large selection of stimuli ensured that this selective response to natural face images was free of low-level visual confounds, as confirmed by the absence of any oddball response for phase-scrambled stimuli. Without any subtraction procedure, time-domain analysis revealed a sequence of differential face-selective EEG components between 120 and 400 ms after oddball face image onset, progressing from medial occipital (P1-faces) to occipitotemporal (N1-faces) and anterior temporal (P2-faces) regions. Overall, this fast periodic visual stimulation approach provides a direct signature of natural face categorization and opens an avenue for efficiently measuring categorization responses of complex visual stimuli in the human brain. © 2015 ARVO.

  1. Fast and robust discrimination of almonds (Prunus amygdalus) with respect to their bitterness by using near infrared and partial least squares-discriminant analysis.

    PubMed

    Borràs, Eva; Amigo, José Manuel; van den Berg, Frans; Boqué, Ricard; Busto, Olga

    2014-06-15

    In this study, near-infrared spectroscopy (NIR) coupled to chemometrics is used to develop a fast, simple, non-destructive and robust method for discriminating sweet and bitter almonds (Prunus amygdalus) by the in situ measurement of the kernel surface without any sample pre-treatment. Principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) models were built to discriminate both types of almonds, obtaining high levels of sensitivity and specificity for both classes, with more than 95% of the samples correctly classified and discriminated. Moreover, the almonds were also analysed by Raman spectroscopy, the reference technique for this type of analysis, to validate and confirm the results obtained by NIR.

  2. Robust, fast and accurate vision-based localization of a cooperative target used for space robotic arm

    NASA Astrophysics Data System (ADS)

    Wen, Zhuoman; Wang, Yanjie; Luo, Jun; Kuijper, Arjan; Di, Nan; Jin, Minghe

    2017-07-01

    When a space robotic arm deploys a payload, usually the pose between the cooperative target fixed on the payload and the hand-eye camera installed on the arm is calculated in real-time. A high-precision robust visual cooperative target localization method is proposed. Combing a circle, a line and dots as markers, a target that guarantees high detection rates is designed. Given an image, single-pixel-width smooth edges are drawn by a novel linking method. Circles are then quickly extracted using isophotes curvature. Around each circle, a square boundary in a pre-calculated proportion to the circle radius is set. In the boundary, the target is identified if certain numbers of lines exist. Based on the circle, the lines, and the target foreground and background intensities, markers are localized. Finally, the target pose is calculated by the Point-3-Perspective algorithm. The algorithm processes 8 frames per second with the target distance ranging from 0.3m to 1.5 m. It generated high-precision poses of above 97.5% on over 100,000 images regardless of camera background, target pose, illumination and motion blur. At 0.3 m, the rotation and translation errors were less than 0.015° and 0.2 mm. The proposed algorithm is very suitable for real-time visual measurement that requires high precision in aerospace.

  3. Fast, continuous recirculation of germinal center B cell populations enhances robustness of immune response towards varying pathogens

    NASA Astrophysics Data System (ADS)

    Or-Guil, Michal

    2009-03-01

    Germinal centers (GCs) are dynamic microstructures that form in lymphatic tissues during immune responses. There, B cells undergo rapid proliferation and mutation of their B cell receptors (BCRs). Selection of B cells bearing BCRs that bind to the pathogen causing the immune response ultimately leads to BCRs that, when secreted as antibodies, form a new, effective, and pathogen specific antibody repertoire. However, the details of this evolutionary process are poorly understood, since currently available experimental techniques do not allow for direct observation of the prevailing mechanisms [Or-Guil et al., Imm.Rev. 2007]. Based on optimality considerations, we put forward the assumption that GCs are not isolated entities where evolutionary processes occur independently, but interconnected structures which allow for continuous exchange of B cells. We show that this architecture leads to a system whose response is much more robust towards different antigen variants than a set of independently working GCs could ever be. We test this hypothesis by generating our own experimental data (time course of 3-D volume distribution of GCs, analysis of high-throughput BCR sequences), and show that available data is consistent with the outlined hypothesis.

  4. Robust fast direct integral equation solver for quasi-periodic scattering problems with a large number of layers.

    PubMed

    Cho, Min Hyung; Barnett, Alex H

    2015-01-26

    We present a new boundary integral formulation for time-harmonic wave diffraction from two-dimensional structures with many layers of arbitrary periodic shape, such as multilayer dielectric gratings in TM polarization. Our scheme is robust at all scattering parameters, unlike the conventional quasi-periodic Green's function method which fails whenever any of the layers approaches a Wood anomaly. We achieve this by a decomposition into near- and far-field contributions. The former uses the free-space Green's function in a second-kind integral equation on one period of the material interfaces and their immediate left and right neighbors; the latter uses proxy point sources and small least-squares solves (Schur complements) to represent the remaining contribution from distant copies. By using high-order discretization on interfaces (including those with corners), the number of unknowns per layer is kept small. We achieve overall linear complexity in the number of layers, by direct solution of the resulting block tridiagonal system. For device characterization we present an efficient method to sweep over multiple incident angles, and show a 25× speedup over solving each angle independently. We solve the scattering from a 1000-layer structure with 3 × 105 unknowns to 9-digit accuracy in 2.5 minutes on a desktop workstation.

  5. Development of a robust, fast screening method for the potentiometric determination of iodide in urine and salt samples.

    PubMed

    Machado, Ana; Mesquita, Raquel B R; Oliveira, Sara; Bordalo, Adriano A

    2017-05-15

    In this work, a potentiometric flow injection method is described for the fast bi-parametric determination of iodide and iodate in urine and salt samples. The developed methodology aimed for iodine speciation with a potentially portable system (running on batteries). The iodate reduction to iodide was effectively attained in line within the same manifold. The iodide determination was accomplished in the dynamic range of 2.50×10(-6)-1.00×10(-3)M and the total iodine dynamic range, resulted from iodide plus iodate, was 3.50×10(-6)-2.00×10(-3)M. The calculated limits of detection were 1.39×10(-6)M and 1.77×10(-6)M for iodide and iodate, respectively. A determination rate of 21h(-1) for the bi-parametric iodide and iodate determination was obtained for sample injection. The urine samples (RSD <5.8% for iodide and RSD <7.0% for iodate) results were in agreement with those obtained by the classic Sandell-Kolthoff reaction colorimetric reference procedure (RD <7.0%) and standard samples from Centers for Disease Control and Prevention, Atlanta, USA (CDC) international inter-laboratory EQUIP program. The developed flow method was also successfully applied to the iodide and iodate determination in salt samples (RSD <3.1% for iodate and iodide), with comparable results to conventional procedures. No significant interferences were observed interference percentage <9% for both determinations.

  6. Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection

    NASA Astrophysics Data System (ADS)

    Yuan, Wu; Kut, Carmen; Liang, Wenxuan; Li, Xingde

    2017-03-01

    Cancer is known to alter the local optical properties of tissues. The detection of OCT-based optical attenuation provides a quantitative method to efficiently differentiate cancer from non-cancer tissues. In particular, the intraoperative use of quantitative OCT is able to provide a direct visual guidance in real time for accurate identification of cancer tissues, especially these without any obvious structural layers, such as brain cancer. However, current methods are suboptimal in providing high-speed and accurate OCT attenuation mapping for intraoperative brain cancer detection. In this paper, we report a novel frequency-domain (FD) algorithm to enable robust and fast characterization of optical attenuation as derived from OCT intensity images. The performance of this FD algorithm was compared with traditional fitting methods by analyzing datasets containing images from freshly resected human brain cancer and from a silica phantom acquired by a 1310 nm swept-source OCT (SS-OCT) system. With graphics processing unit (GPU)-based CUDA C/C++ implementation, this new attenuation mapping algorithm can offer robust and accurate quantitative interpretation of OCT images in real time during brain surgery.

  7. Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection

    PubMed Central

    Yuan, Wu; Kut, Carmen; Liang, Wenxuan; Li, Xingde

    2017-01-01

    Cancer is known to alter the local optical properties of tissues. The detection of OCT-based optical attenuation provides a quantitative method to efficiently differentiate cancer from non-cancer tissues. In particular, the intraoperative use of quantitative OCT is able to provide a direct visual guidance in real time for accurate identification of cancer tissues, especially these without any obvious structural layers, such as brain cancer. However, current methods are suboptimal in providing high-speed and accurate OCT attenuation mapping for intraoperative brain cancer detection. In this paper, we report a novel frequency-domain (FD) algorithm to enable robust and fast characterization of optical attenuation as derived from OCT intensity images. The performance of this FD algorithm was compared with traditional fitting methods by analyzing datasets containing images from freshly resected human brain cancer and from a silica phantom acquired by a 1310 nm swept-source OCT (SS-OCT) system. With graphics processing unit (GPU)-based CUDA C/C++ implementation, this new attenuation mapping algorithm can offer robust and accurate quantitative interpretation of OCT images in real time during brain surgery. PMID:28327613

  8. Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection.

    PubMed

    Yuan, Wu; Kut, Carmen; Liang, Wenxuan; Li, Xingde

    2017-03-22

    Cancer is known to alter the local optical properties of tissues. The detection of OCT-based optical attenuation provides a quantitative method to efficiently differentiate cancer from non-cancer tissues. In particular, the intraoperative use of quantitative OCT is able to provide a direct visual guidance in real time for accurate identification of cancer tissues, especially these without any obvious structural layers, such as brain cancer. However, current methods are suboptimal in providing high-speed and accurate OCT attenuation mapping for intraoperative brain cancer detection. In this paper, we report a novel frequency-domain (FD) algorithm to enable robust and fast characterization of optical attenuation as derived from OCT intensity images. The performance of this FD algorithm was compared with traditional fitting methods by analyzing datasets containing images from freshly resected human brain cancer and from a silica phantom acquired by a 1310 nm swept-source OCT (SS-OCT) system. With graphics processing unit (GPU)-based CUDA C/C++ implementation, this new attenuation mapping algorithm can offer robust and accurate quantitative interpretation of OCT images in real time during brain surgery.

  9. The Tofts model in frequency domain: fast and robust determination of pharmacokinetic maps for dynamic contrast enhancement MRI

    NASA Astrophysics Data System (ADS)

    Vajuvalli, Nithin N.; Chikkemenahally, Dharmendra Kumar K.; Nayak, Krupa N.; Bhosale, Manoj G.; Geethanath, Sairam

    2016-12-01

    Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) is a well-established method for non-invasive detection and therapeutic monitoring of pathologies through administration of intravenous contrast agent. Quantification of pharmacokinetic (PK) maps can be achieved through application of compartmental models relevant to the pathophysiology of the tissue under interrogation. The determination of PK parameters involves fitting of time-concentration data to these models. In this work, the Tofts model in frequency domain (TM-FD) is applied to a weakly vascularized tissue such as the breast. It is derived as a convolution-free model from the conventional Tofts model in the time domain (TM-TD). This reduces the dimensionality of the curve-fitting problem from two to one. The approaches of TM-FD and TM-TD were applied to two kinds of in silico phantoms and six in vivo breast DCE data sets with and without the addition of noise. The results showed that computational time taken to estimate PK maps using TM-FD was 16-25% less than with TM-TD. Normalized root mean square error (NRMSE) calculation and Pearson correlation analyses were performed to validate robustness and accuracy of the TM-FD and TM-TD approaches. These compared with ground truth values in the case of phantom studies for four different temporal resolutions. Results showed that NRMSE values for TM-FD were significantly lower than those of TM-TD as validated by a paired t-test along with reduced computational time. This approach therefore enables online evaluation of PK maps by radiologists in a clinical setting, aiding in the evaluation of 3D and/or increased coverage of the tissue of interest.

  10. A fast and robust new pore-network extraction method based on hybrid median axis and maximal inscribed ball techniques

    NASA Astrophysics Data System (ADS)

    Timofey, Sizonenko; Karsanina, Marina; Byuk, Irina; Gerke, Kirill

    2016-04-01

    To characterize pore structure relevant to single and multi-phase flow modelling it is of special interest to extract topology of the pore space. This is usually achieved using so-called pore-network models. Such models are useful not only to characterize pore space and pore size distributions, but also provide means to simulate flow and transport with very limited computational resources compared to other pore-scale modelling techniques. The main drawback of the pore-network approach is that they have first to simplify the pore space geometry. This crucial step is both time consuming and prone to numerous errors. Two most popular methods based on median axis or inscribed maximal balls have their own strong sides and disadvantages. To address aforementioned problems related to pore-network extraction here we propose a novel method utilizing the advantages of both popular approaches. Combining two algorithms resulted in much faster and robust extraction methodology. Moreover, we have found that accurate topology representation requires extension of the conventional pore-body and pore-throat classification. We test our new methodology using pore structures with "analytical solutions" such as different sphere packs. In addition, we rigorously compare it against inscribed maximal balls methodology's results using numerous 3D images of sandstone and carbonate rocks, soils and some other porous materials. Another verification includes permeability calculations which are also compared both against lab data and voxel based pore-scale modelling simulations. This work was partially supported by RFBR grant 15-34-20989 (X-ray tomography and image fusion) and RSF grant 14-17-00658 (image segmentation and pore-scale modelling).

  11. Stuttering Interneurons Generate Fast and Robust Inhibition onto Projection Neurons with Low Capacity of Short Term Modulation in Mouse Lateral Amygdala

    PubMed Central

    Song, Chen; Xu, Xiao-Bin; He, Ye; Liu, Zhi-Peng; Wang, Min; Zhang, Xin; Li, Bao-Ming; Pan, Bing-Xing

    2013-01-01

    The stuttering interneurons (STi) represent one minor subset of interneuron population and exhibit characteristic stuttering firing upon depolarization current injection. While it has been long held that the GABAergic inhibitory transmission largely varies with the subtype identity of presynaptic interneurons, whether such a rule also applies to STi is largely unknown. Here, by paired recording of interneuron and their neighboring projection neuron in lateral amygdala, we found that relative to the fast spiking and late spiking interneurons, the STi-evoked unitary postsynaptic currents onto the projection neurons had markedly larger amplitude, shorter onset latency and faster rising and decay kinetics. The quantal content and the number of vesicles in the readily releasable pool were also larger in synapses made by STi versus other interneurons. Moreover, the short-term plasticity, as reflected by the paired pulse depression and depolarization-induced suppression of inhibition, was the least prominent in the output synapses of STi. Thus, the fast and robust inhibition together with its low capacity of short term modulation may suggest an important role for STi in preventing the overexcitation of the projection neurons and thus gating the information traffic in amygdala. PMID:23527307

  12. Fast and robust method for the determination of microstructure and composition in butadiene, styrene-butadiene, and isoprene rubber by near-infrared spectroscopy.

    PubMed

    Vilmin, Franck; Dussap, Claude; Coste, Nathalie

    2006-06-01

    In the tire industry, synthetic styrene-butadiene rubber (SBR), butadiene rubber (BR), and isoprene rubber (IR) elastomers are essential for conferring to the product its properties of grip and rolling resistance. Their physical properties depend on their chemical composition, i. e., their microstructure and styrene content, which must be accurately controlled. This paper describes a fast, robust, and highly reproducible near-infrared analytical method for the quantitative determination of the microstructure and styrene content. The quantitative models are calculated with the help of pure spectral profiles estimated from a partial least squares (PLS) regression, using (13)C nuclear magnetic resonance (NMR) as the reference method. This versatile approach allows the models to be applied over a large range of compositions, from a single BR to an SBR-IR blend. The resulting quantitative predictions are independent of the sample path length. As a consequence, the sample preparation is solvent free and simplified with a very fast (five minutes) hot filming step of a bulk polymer piece. No precise thickness control is required. Thus, the operator effect becomes negligible and the method is easily transferable. The root mean square error of prediction, depending on the rubber composition, is between 0.7% and 1.3%. The reproducibility standard error is less than 0.2% in every case.

  13. Contact Isotropic Realisations of Jacobi Manifolds via Spencer Operators

    NASA Astrophysics Data System (ADS)

    Salazar, María Amelia; Sepe, Daniele

    2017-05-01

    Motivated by the importance of symplectic isotropic realisations in the study of Poisson manifolds, this paper investigates the local and global theory of contact isotropic realisations of Jacobi manifolds, which are those of minimal dimension. These arise naturally when considering multiplicity-free actions in contact geometry, as shown in this paper. The main results concern a classification of these realisations up to a suitable notion of isomorphism, as well as establishing a relation between the existence of symplectic and contact isotropic realisations for Poisson manifolds. The main tool is the classical Spencer operator which is related to Jacobi structures via their associated Lie algebroid, which allows to generalise previous results as well as providing more conceptual proofs for existing ones.

  14. A robust index of lexical representation in the left occipito-temporal cortex as evidenced by EEG responses to fast periodic visual stimulation.

    PubMed

    Lochy, Aliette; Van Belle, Goedele; Rossion, Bruno

    2015-01-01

    Despite decades of research on reading, including the relatively recent contributions of neuroimaging and electrophysiology, identifying selective representations of whole visual words (in contrast to pseudowords) in the human brain remains challenging, in particular without an explicit linguistic task. Here we measured discrimination responses to written words by means of electroencephalography (EEG) during fast periodic visual stimulation. Sequences of pseudofonts, nonwords, or pseudowords were presented through sinusoidal contrast modulation at a periodic 10 Hz frequency rate (F), in which words were interspersed at regular intervals of every fifth item (i.e., F/5, 2 Hz). Participants monitored a central cross color change and had no linguistic task to perform. Within only 3 min of stimulation, a robust discrimination response for words at 2 Hz (and its harmonics, i.e., 4 and 6 Hz) was observed in all conditions, located predominantly over the left occipito-temporal cortex. The magnitude of the response was largest for words embedded in pseudofonts, and larger in nonwords than in pseudowords, showing that list context effects classically reported in behavioral lexical decision tasks are due to visual discrimination rather than decisional processes. Remarkably, the oddball response was significant even for the critical words/pseudowords discrimination condition in every individual participant. A second experiment replicated this words/pseudowords discrimination, and showed that this effect is not accounted for by a higher bigram frequency of words than pseudowords. Without any explicit task, our results highlight the potential of an EEG fast periodic visual stimulation approach for understanding the representation of written language. Its development in the scientific community might be valuable to rapidly and objectively measure sensitivity to word processing in different human populations, including neuropsychological patients with dyslexia and other reading

  15. Realising the Uncertainty Enabled Model Web

    NASA Astrophysics Data System (ADS)

    Cornford, D.; Bastin, L.; Pebesma, E. J.; Williams, M.; Stasch, C.; Jones, R.; Gerharz, L.

    2012-12-01

    The FP7 funded UncertWeb project aims to create the "uncertainty enabled model web". The central concept here is that geospatial models and data resources are exposed via standard web service interfaces, such as the Open Geospatial Consortium (OGC) suite of encodings and interface standards, allowing the creation of complex workflows combining both data and models. The focus of UncertWeb is on the issue of managing uncertainty in such workflows, and providing the standards, architecture, tools and software support necessary to realise the "uncertainty enabled model web". In this paper we summarise the developments in the first two years of UncertWeb, illustrating several key points with examples taken from the use case requirements that motivate the project. Firstly we address the issue of encoding specifications. We explain the usage of UncertML 2.0, a flexible encoding for representing uncertainty based on a probabilistic approach. This is designed to be used within existing standards such as Observations and Measurements (O&M) and data quality elements of ISO19115 / 19139 (geographic information metadata and encoding specifications) as well as more broadly outside the OGC domain. We show profiles of O&M that have been developed within UncertWeb and how UncertML 2.0 is used within these. We also show encodings based on NetCDF and discuss possible future directions for encodings in JSON. We then discuss the issues of workflow construction, considering discovery of resources (both data and models). We discuss why a brokering approach to service composition is necessary in a world where the web service interfaces remain relatively heterogeneous, including many non-OGC approaches, in particular the more mainstream SOAP and WSDL approaches. We discuss the trade-offs between delegating uncertainty management functions to the service interfaces themselves and integrating the functions in the workflow management system. We describe two utility services to address

  16. Robust, spatially scanning, open-path TDLAS hygrometer using retro-reflective foils for fast tomographic 2-D water vapor concentration field measurements

    NASA Astrophysics Data System (ADS)

    Seidel, A.; Wagner, S.; Dreizler, A.; Ebert, V.

    2015-05-01

    We have developed a fast, spatially scanning direct tunable diode laser absorption spectrometer (dTDLAS) that combines four polygon-mirror based scanning units with low-cost retro-reflective foils. With this instrument, tomographic measurements of absolute 2-D water vapor concentration profiles are possible without any calibration using a reference gas. A spatial area of 0.8 m x 0.8 m was covered, which allows for application in soil physics, where greenhouse gas emission from certain soil structures shall be monitored. The whole concentration field was measured with up to 2.5 Hz. In this paper, we present the setup and spectroscopic performance of the instrument regarding the influence of the polygon rotation speed and mode on the absorption signal. Homogeneous H2O distributions were measured and compared to a single channel, bi-static reference TDLAS spectrometer for validation of the instrument. Good accuracy and precision with errors of less than 6% of the absolute concentration and length and bandwidth normalized detection limits of up to 1.1 ppmv . m (Hz)-0.5 were achieved. The spectrometer is a robust and easy to set up instrument for tomographic reconstructions of 2-D-concentration fields that can be considered as a good basis for future field measurements in environmental research.

  17. A simple, fast, sensitive and robust LC-MS/MS bioanalytical assay for evaluating 7α-hydroxy-4-cholesten-3-one biomarker in a clinical program.

    PubMed

    Yuan, Long; Luo, Yi; Kandoussi, Hamza; Ji, Qin C

    2016-12-01

    Serum 7α-hydroxy-cholesten-3-one (C4) has been reported as a biomarker to assess CYP7A1 enzyme activity and bile acid synthesis. To support a clinical program, a sensitive and reliable assay without derivatization was required for the analysis of C4 in human serum. Methodology & results: A systematic approach was used to optimize mass spectrometry, LC and sample extraction conditions, therefore, significantly improved assay sensitivity, and achieved the required quantification limit without derivatization. A surrogate matrix approach was used to overcome the interference from endogenous C4. A stable isotope-labeled C4 was used as internal standard. The samples were extracted using a simple protein precipitation method with 2% formic acid in acetonitrile. A simple, fast, sensitive and robust UHPLC-MS/MS method for the quantification of 0.50 ng/ml C4 in 100 µl human serum was developed and fit for purpose validated. The method was successfully applied to the bioanalysis of C4 in a clinical study.

  18. Robust extrapolation scheme for fast estimation of 3D ising field partition functions: application to within-subject fMRI data analysis.

    PubMed

    Risser, Laurent; Vincent, Thomas; Ciuciu, Philippe; Idier, Jérôme

    2009-01-01

    In this paper, we present a fast numerical scheme to estimate Partition Functions (PF) of 3D Ising fields. Our strategy is applied to the context of the joint detection-estimation of brain activity from functional Magnetic Resonance Imaging (fMRI) data, where the goal is to automatically recover activated regions and estimate region-dependent hemodynamic filters. For any region, a specific binary Markov random field may embody spatial correlation over the hidden states of the voxels by modeling whether they are activated or not. To make this spatial regularization fully adaptive, our approach is first based upon a classical path-sampling method to approximate a small subset of reference PFs corresponding to prespecified regions. Then, the proposed extrapolation method allows us to approximate the PFs associated with the Ising fields defined over the remaining brain regions. In comparison with preexisting approaches, our method is robust to topological inhomogeneities in the definition of the reference regions. As a result, it strongly alleviates the computational burden and makes spatially adaptive regularization of whole brain fMRI datasets feasible.

  19. Robust, spatially scanning, open-path TDLAS hygrometer using retro-reflective foils for fast tomographic 2-D water vapour concentration field measurements

    NASA Astrophysics Data System (ADS)

    Seidel, A.; Wagner, S.; Dreizler, A.; Ebert, V.

    2014-12-01

    We have developed a fast, spatially direct scanning tunable diode laser absorption spectrometer (dTDLAS) that combines four polygon-mirror based scanning units with low-cost retro-reflective foils. With this instrument, tomographic measurements of absolute 2-D water vapour concentration profiles are possible without any calibration using a reference gas. A spatial area of 0.8 m × 0.8 m was covered, which allows for application in soil physics, where greenhouse gas emission from certain soil structures shall be monitored. The whole concentration field was measured with up to 2.5 Hz. In this paper, we present the setup and spectroscopic performance of the instrument regarding the influence of the polygon rotation speed and mode on the absorption signal. Homogeneous H2O distributions were measured and compared to a single channel, bi-static reference TDLAS spectrometer for validation of the instrument. Good accuracy and precision with errors of less than 6% of the absolute concentration and length and bandwidth normalized detection limits of up to 1.1 ppmv · m · √Hz-1 were achieved. The spectrometer is a robust and easy to set up instrument for tomographic reconstructions of 2-D-concentration fields that can be considered a good basis for future field measurements in environmental research.

  20. Disseminating the unit of mass from multiple primary realisations

    NASA Astrophysics Data System (ADS)

    Nielsen, Lars

    2016-12-01

    When a new definition of the kilogram has been adopted in 2018 as expected, the unit of mass will be realised by the watt balance method, the x-ray crystal density method or perhaps other primary methods still to be developed. So far, the standard uncertainties associated with the available primary methods are at least one order of magnitude larger than the standard uncertainty associated with mass comparisons using mass comparators, so differences in primary realisations of the kilogram are easily detected, whereas many National Metrology Institutes would have to increase their calibration and measurement capabilities (CMCs) if they were traceable to a single primary realisation. This paper presents a scheme for obtaining traceability to multiple primary realisations of the kilogram using a small group of stainless steel 1 kg weights, which are allowed to change their masses over time in a way known to be realistic, and which are calibrated and stored in air. An analysis of the scheme shows that if the relative standard uncertainties of future primary realisations are equal to the relative standard uncertainties of the present methods used to measure the Planck constant, the unit of mass can be disseminated with a standard uncertainty less than 0.015 mg, which matches the smallest CMCs currently claimed for the calibration of 1 kg weights.

  1. Detector Based Realisation of Illuminance Scale at NML-SIRIM

    NASA Astrophysics Data System (ADS)

    Abdullah, Mohd Nizam; Abidin, Mohd Nasir Zainal; Abidin, Abdul Rashid Zainal; Shaari, Sahbudin

    2009-07-01

    Illuminance scale is one of the fundamentals in the realisation of candela in optical radiation. The en route of the realisation is based on the fundamental process from the unbroken chain of traceability which includes from the primary standard disseminated to working standard and lastly the end user. There are many variations towards this realisation even though some of the national metrology institutes (NMI) does not have the primary standard but their traceability still valid. The realisation of National Metrology Laboratory SIRIM (NML-SIRIM), Malaysia illuminance scale is based on detector. The scale is traceable to National Physical Labortaory (NPL), United Kingdom (UK) by annually calibrating photometers and luminous intensity lamp. This paper describes measurement method and the system set-up was previously crosschecked with Korea Research Institute Standards and Science (KRISS), Republic of Korea. The agreement between both laboratories is within 0.5% the uncertainty maintained at NML-SIRIM. Furthermore, the basic measurement equation for illuminance realisation is also derived.

  2. Fast, accurate, and robust automatic marker detection for motion correction based on oblique kV or MV projection image pairs.

    PubMed

    Slagmolen, Pieter; Hermans, Jeroen; Maes, Frederik; Budiharto, Tom; Haustermans, Karin; van den Heuvel, Frank

    2010-04-01

    a second where most time is spent on the image preprocessing. The authors have developed a method to automatically detect multiple markers in a pair of projection images that is robust, accurate, and sufficiently fast for clinical use. It can be used for kV, MV, or mixed image pairs and can cope with limited motion between the projection images.

  3. Reliability of simulated robustness testing in fast liquid chromatography, using state-of-the-art column technology, instrumentation and modelling software.

    PubMed

    Kormány, Róbert; Fekete, Jenő; Guillarme, Davy; Fekete, Szabolcs

    2014-02-01

    The goal of this study was to evaluate the accuracy of simulated robustness testing using commercial modelling software (DryLab) and state-of-the-art stationary phases. For this purpose, a mixture of amlodipine and its seven related impurities was analyzed on short narrow bore columns (50×2.1mm, packed with sub-2μm particles) providing short analysis times. The performance of commercial modelling software for robustness testing was systematically compared to experimental measurements and DoE based predictions. We have demonstrated that the reliability of predictions was good, since the predicted retention times and resolutions were in good agreement with the experimental ones at the edges of the design space. In average, the retention time relative errors were <1.0%, while the predicted critical resolution errors were comprised between 6.9 and 17.2%. Because the simulated robustness testing requires significantly less experimental work than the DoE based predictions, we think that robustness could now be investigated in the early stage of method development. Moreover, the column interchangeability, which is also an important part of robustness testing, was investigated considering five different C8 and C18 columns packed with sub-2μm particles. Again, thanks to modelling software, we proved that the separation was feasible on all columns within the same analysis time (less than 4min), by proper adjustments of variables. Copyright © 2013 Elsevier B.V. All rights reserved.

  4. Forkhead Box O1 (FOXO1) Protein, but Not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice*

    PubMed Central

    Tinkum, Kelsey L.; White, Lynn S.; Marpegan, Luciano; Herzog, Erik; Piwnica-Worms, David; Piwnica-Worms, Helen

    2013-01-01

    Reporter mice that enable the activity of the endogenous p21 promoter to be dynamically monitored in real time in vivo and under a variety of experimental conditions revealed ubiquitous p21 expression in mouse organs including the brain. Low light bioluminescence microscopy was employed to localize p21 expression to specific regions of the brain. Interestingly, p21 expression was observed in the paraventricular, arcuate, and dorsomedial nuclei of the hypothalamus, regions that detect nutrient levels in the blood stream and signal metabolic actions throughout the body. These results suggested a link between p21 expression and metabolic regulation. We found that short-term food deprivation (fasting) potently induced p21 expression in tissues involved in metabolic regulation including liver, pancreas and hypothalamic nuclei. Conditional reporter mice were generated that enabled hepatocyte-specific expression of p21 to be monitored in vivo. Bioluminescence imaging demonstrated that fasting induced a 7-fold increase in p21 expression in livers of reporter mice and Western blotting demonstrated an increase in protein levels as well. The ability of fasting to induce p21 expression was found to be independent of p53 but dependent on FOXO1. Finally, occupancy of the endogenous p21 promoter by FOXO1 was observed in the livers of fasted but not fed mice. Thus, fasting promotes loading of FOXO1 onto the p21 promoter to induce p21 expression in hepatocytes. PMID:23918930

  5. Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice.

    PubMed

    Tinkum, Kelsey L; White, Lynn S; Marpegan, Luciano; Herzog, Erik; Piwnica-Worms, David; Piwnica-Worms, Helen

    2013-09-27

    Reporter mice that enable the activity of the endogenous p21 promoter to be dynamically monitored in real time in vivo and under a variety of experimental conditions revealed ubiquitous p21 expression in mouse organs including the brain. Low light bioluminescence microscopy was employed to localize p21 expression to specific regions of the brain. Interestingly, p21 expression was observed in the paraventricular, arcuate, and dorsomedial nuclei of the hypothalamus, regions that detect nutrient levels in the blood stream and signal metabolic actions throughout the body. These results suggested a link between p21 expression and metabolic regulation. We found that short-term food deprivation (fasting) potently induced p21 expression in tissues involved in metabolic regulation including liver, pancreas and hypothalamic nuclei. Conditional reporter mice were generated that enabled hepatocyte-specific expression of p21 to be monitored in vivo. Bioluminescence imaging demonstrated that fasting induced a 7-fold increase in p21 expression in livers of reporter mice and Western blotting demonstrated an increase in protein levels as well. The ability of fasting to induce p21 expression was found to be independent of p53 but dependent on FOXO1. Finally, occupancy of the endogenous p21 promoter by FOXO1 was observed in the livers of fasted but not fed mice. Thus, fasting promotes loading of FOXO1 onto the p21 promoter to induce p21 expression in hepatocytes.

  6. Myrrha, Technology Development for the Realisation of ADS in Eu:. Current Status & Prospects for Realisation

    NASA Astrophysics Data System (ADS)

    Fernandez, R.; Abderrahim, H. Aït; Baeten, P.; de Bruyn, D.; Maes, D.; Mazouzi, A. Al; Ariën, B.; Malambu, E.; Schuurmans, P.; Schyns, M.; Sobolev, V.; van den Eynde, G.; Vandeplassche, D.

    2010-06-01

    The coupling between an accelerator, a spallation target and a subcritical core has been studied for the first time at SCK•CEN in collaboration with Ion Beam Applications (IBA, Louvain-la-Neuve) in the frame of the ADONIS project (1995-1997). ADONIS was a small irradiation facility, based on the ADS concept, having a dedicated objective to produce radioisotopes for medical purposes and more particularly 99Mo as a fission product from highly enriched 235U (HEU) fissile targets. The ad-hoc scientific advisory committee recommended extending the purpose of the ADONIS machine to become a Material Testing Reactor (MTR) for material and fuel research, to study the feasibility of transmutation of the minor actinides and to demonstrate at a reasonable power scale the principle of the ADS. The project, since 1998 named MYRRHA, has then evolved to a larger installation. MYRRHA is now conceived as a flexible irradiation facility, able to work as an Accelerator Driven (subcritical mode) and in critical mode. In this way, MYRRHA will allow fuel developments for innovative reactor systems, material developments for GEN IV systems, material developments for fusion reactors, radioisotope production for medical and industrial applications and industrial applications, such as Si-doping. MYRRHA will also demonstrate the ADS full concept by coupling the three components (accelerator, spallation target and subcritical reactor) at reasonable power level to allow operation feedback, scalable to an industrial demonstrator and allow the study of efficient transmutation of high-level nuclear waste. Since MYRRHA is based on the heavy liquid metal technology, the eutectic lead-bismuth, it will be able to significantly contribute to the development of Lead Fast Reactor Technology. Since MYRRHA will also be operated in critical mode, MYRRHA can even better play the role of European Technology Pilot Plant in the roadmap for LFR.

  7. PANET: A GPU-Based Tool for Fast Parallel Analysis of Robustness Dynamics and Feed-Forward/Feedback Loop Structures in Large-Scale Biological Networks

    PubMed Central

    Trinh, Hung-Cuong; Le, Duc-Hau; Kwon, Yung-Keun

    2014-01-01

    It has been a challenge in systems biology to unravel relationships between structural properties and dynamic behaviors of biological networks. A Cytoscape plugin named NetDS was recently proposed to analyze the robustness-related dynamics and feed-forward/feedback loop structures of biological networks. Despite such a useful function, limitations on the network size that can be analyzed exist due to high computational costs. In addition, the plugin cannot verify an intrinsic property which can be induced by an observed result because it has no function to simulate the observation on a large number of random networks. To overcome these limitations, we have developed a novel software tool, PANET. First, the time-consuming parts of NetDS were redesigned to be processed in parallel using the OpenCL library. This approach utilizes the full computing power of multi-core central processing units and graphics processing units. Eventually, this made it possible to investigate a large-scale network such as a human signaling network with 1,609 nodes and 5,063 links. We also developed a new function to perform a batch-mode simulation where it generates a lot of random networks and conducts robustness calculations and feed-forward/feedback loop examinations of them. This helps us to determine if the findings in real biological networks are valid in arbitrary random networks or not. We tested our plugin in two case studies based on two large-scale signaling networks and found interesting results regarding relationships between coherently coupled feed-forward/feedback loops and robustness. In addition, we verified whether or not those findings are consistently conserved in random networks through batch-mode simulations. Taken together, our plugin is expected to effectively investigate various relationships between dynamics and structural properties in large-scale networks. Our software tool, user manual and example datasets are freely available at http

  8. PANET: a GPU-based tool for fast parallel analysis of robustness dynamics and feed-forward/feedback loop structures in large-scale biological networks.

    PubMed

    Trinh, Hung-Cuong; Le, Duc-Hau; Kwon, Yung-Keun

    2014-01-01

    It has been a challenge in systems biology to unravel relationships between structural properties and dynamic behaviors of biological networks. A Cytoscape plugin named NetDS was recently proposed to analyze the robustness-related dynamics and feed-forward/feedback loop structures of biological networks. Despite such a useful function, limitations on the network size that can be analyzed exist due to high computational costs. In addition, the plugin cannot verify an intrinsic property which can be induced by an observed result because it has no function to simulate the observation on a large number of random networks. To overcome these limitations, we have developed a novel software tool, PANET. First, the time-consuming parts of NetDS were redesigned to be processed in parallel using the OpenCL library. This approach utilizes the full computing power of multi-core central processing units and graphics processing units. Eventually, this made it possible to investigate a large-scale network such as a human signaling network with 1,609 nodes and 5,063 links. We also developed a new function to perform a batch-mode simulation where it generates a lot of random networks and conducts robustness calculations and feed-forward/feedback loop examinations of them. This helps us to determine if the findings in real biological networks are valid in arbitrary random networks or not. We tested our plugin in two case studies based on two large-scale signaling networks and found interesting results regarding relationships between coherently coupled feed-forward/feedback loops and robustness. In addition, we verified whether or not those findings are consistently conserved in random networks through batch-mode simulations. Taken together, our plugin is expected to effectively investigate various relationships between dynamics and structural properties in large-scale networks. Our software tool, user manual and example datasets are freely available at http://panet-csc.sourceforge.net/.

  9. Robust multigrid for high-order discontinuous Galerkin methods: A fast Poisson solver suitable for high-aspect ratio Cartesian grids

    NASA Astrophysics Data System (ADS)

    Stiller, Jörg

    2016-12-01

    We present a polynomial multigrid method for nodal interior penalty and local discontinuous Galerkin formulations of the Poisson equation on Cartesian grids. For smoothing we propose two classes of overlapping Schwarz methods. The first class comprises element-centered and the second face-centered methods. Within both classes we identify methods that achieve superior convergence rates, prove robust with respect to the mesh spacing and the polynomial order, at least up to P = 32. Consequent structure exploitation yields a computational complexity of O (PN), where N is the number of unknowns. Further we demonstrate the suitability of the face-centered method for element aspect ratios up to 32.

  10. Public choice economics and space policy: realising space tourism

    NASA Astrophysics Data System (ADS)

    Collins, Patrick

    2001-03-01

    Government space agencies have the statutory responsibility to suport the commercialisation of space activities. NASA's 1998 report "General Public Space Travel and Tourism" concluded that passenger space travel can start using already existing technology, and is likely to grow into the largest commercial activity in space: it is therefore greatly in taxpayers' economic interest that passenger space travel and accommodation industries should be developed. However, space agencies are doing nothing to help realise this — indeed, they are actively delaying it. This behaviour is predicted by 'public choice' economics, pioneered by Professors George Stigler and James Buchanan who received the 1982 and 1986 Nobel prizes for Economics, which views government organisations as primarily self-interested. The paper uses this viewpoint to discuss public and private roles in the coming development of a space tourism industry.

  11. Realising traceable electrostatic forces despite non-linear balance motion

    NASA Astrophysics Data System (ADS)

    Stirling, Julian; Shaw, Gordon A.

    2017-05-01

    Direct realisation of force, traceable to fundamental constants via electromagnetic balances, is a key goal of the proposed redefinition of the international system of units (SI). This will allow small force metrology to be performed using an electrostatic force balance (EFB) rather than subdivision of larger forces. Such a balance uses the electrostatic force across a capacitor to balance an external force. In this paper we model the capacitance of a concentric cylinder EFB design as a function of the displacement of its free electrode, accounting for the arcuate motion produced by parallelogram linkages commonly used in EFB mechanisms. From this model we suggest new fitting procedures to reduce uncertainties arising from non-linear motion as well as methods to identify misalignment of the mechanism. Experimental studies on both a test capacitor and the NIST EFB validate the model.

  12. Two‐dimensional‐NGC‐SENSE‐GRAPPA for fast, ghosting‐robust reconstruction of in‐plane and slice‐accelerated blipped‐CAIPI echo planar imaging

    PubMed Central

    2016-01-01

    Purpose Ghosting‐robust reconstruction of blipped‐CAIPI echo planar imaging simultaneous multislice data with low computational load. Methods To date, Slice‐GRAPPA, with “odd–even” kernels that improve ghosting performance, has been the framework of choice for such reconstructions due to its predecessor SENSE‐GRAPPA being deemed unsuitable for blipped‐CAIPI data. Modifications to SENSE‐GRAPPA are used to restore CAIPI compatibility and to make it robust against ghosting. Two implementations are tested, one where slices and in‐plane unaliasing are dealt in the same serial manner as in Slice‐GRAPPA [referred to as one‐dimensional (1D)‐NGC‐SENSE‐GRAPPA, where NGC stands for Nyquist Ghost Corrected] and one where both are unaliased in a single step (2D‐NGC‐SENSE‐GRAPPA), which is analytically and experimentally shown to be computationally cheaper. Results The 1D‐NGC‐SENSE‐GRAPPA and odd‐even Slice‐GRAPPA perform identically, whereas 2D‐NGC‐SENSE‐GRAPPA shows reduced error propagation, less residual ghosting when reliable reference data were available. When the latter was not the case, error propagation was increased. Conclusion Unlike Slice‐GRAPPA, SENSE‐GRAPPA operates fully within the GRAPPA framework, for which improved reconstructions (e.g., iterative, nonlinear) have been developed over the past decade. It could, therefore, bring benefit to the reconstruction of SMS data as an attractive alternative to Slice‐GRAPPA. Magn Reson Med 77:998–1009, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. PMID:26932565

  13. Fast and accurate finite element analysis of large-scale three-dimensional photonic devices with a robust domain decomposition method.

    PubMed

    Xue, Ming-Feng; Kang, Young Mo; Arbabi, Amir; McKeown, Steven J; Goddard, Lynford L; Jin, Jian-Ming

    2014-02-24

    A fast and accurate full-wave technique based on the dual-primal finite element tearing and interconnecting method and the second-order transmission condition is presented for large-scale three-dimensional photonic device simulations. The technique decomposes a general three-dimensional electromagnetic problem into smaller subdomain problems so that parallel computing can be performed on distributed-memory computer clusters to reduce the simulation time significantly. With the electric fields computed everywhere, photonic device parameters such as transmission and reflection coefficients are extracted. Several photonic devices, with simulation volumes up to 1.9×10(4) (λ/n(avg))3 and modeled with over one hundred million unknowns, are simulated to demonstrate the application, efficiency, and capability of this technique. The simulations show good agreement with experimental results and in a special case with a simplified two-dimensional simulation.

  14. A fast-initiating ionically tagged ruthenium complex: a robust supported pre-catalyst for batch-process and continuous-flow olefin metathesis.

    PubMed

    Borré, Etienne; Rouen, Mathieu; Laurent, Isabelle; Magrez, Magaly; Caijo, Fréderic; Crévisy, Christophe; Solodenko, Wladimir; Toupet, Loic; Frankfurter, René; Vogt, Carla; Kirschning, Andreas; Mauduit, Marc

    2012-12-14

    In this study, a new pyridinium-tagged Ru complex was designed and anchored onto sulfonated silica, thereby forming a robust and highly active supported olefin-metathesis pre-catalyst for applications under batch and continuous-flow conditions. The involvement of an oxazine-benzylidene ligand allowed the reactivity of the formed Ru pre-catalyst to be efficiently controlled through both steric and electronic activation. The oxazine scaffold facilitated the introduction of the pyridinium tag, thereby affording the corresponding cationic pre-catalyst in good yield. Excellent activities in ring-closing (RCM), cross (CM), and enyne metathesis were observed with only 0.5 mol % loading of the pre-catalyst. When this powerful pre-catalyst was immobilized onto a silica-based cationic-exchange resin, a versatile catalytically active material for batch reactions was generated that also served as fixed-bed material for flow reactors. This system could be reused at 1 mol % loading to afford metathesis products in high purity with very low ruthenium contamination under batch conditions (below 5 ppm). Scavenging procedures for both batch and flow processes were conducted, which led to a lowering of the ruthenium content to as little as one tenth of the original values. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion

    NASA Astrophysics Data System (ADS)

    Liu, Jing; Sun, Yang; Qi, Jinyi; Marcu, Laura

    2012-02-01

    We report a novel method for estimating fluorescence impulse response function (fIRF) from noise-corrupted time-domain fluorescence measurements of biological tissue. This method is based on the use of high-order Laguerre basis functions and a constrained least-squares approach that addresses the problem of overfitting due to increased model complexity. The new method was extensively evaluated on fluorescence data from simulation, fluorescent standard dyes, ex vivo tissue samples of atherosclerotic plaques and in vivo oral carcinoma. Current results demonstrate that this method allows for rapid and accurate deconvolution of multiple channel fluorescence decays without adaptively adjusting the Laguerre scale parameter. The appropriate choice of the scale parameter is essential for accurate estimation of the fIRF. The method described here is anticipated to play an important role in the development of computational techniques for real-time analysis of time-resolved fluorescence data from biological tissues and to support the advancement of fluorescence lifetime instrumentation for biomedical diagnostics by providing a means for on-line robust analysis of fluorescence decay.

  16. High hopes: can molecular electronics realise its potential?

    PubMed

    Coskun, Ali; Spruell, Jason M; Barin, Gokhan; Dichtel, William R; Flood, Amar H; Botros, Youssry Y; Stoddart, J Fraser

    2012-07-21

    Manipulating and controlling the self-organisation of small collections of molecules, as an alternative to investigating individual molecules, has motivated researchers bent on processing and storing information in molecular electronic devices (MEDs). Although numerous ingenious examples of single-molecule devices have provided fundamental insights into their molecular electronic properties, MEDs incorporating hundreds to thousands of molecules trapped between wires in two-dimensional arrays within crossbar architectures offer a glimmer of hope for molecular memory applications. In this critical review, we focus attention on the collective behaviour of switchable mechanically interlocked molecules (MIMs)--specifically, bistable rotaxanes and catenanes--which exhibit reset lifetimes between their ON and OFF states ranging from seconds in solution to hours in crossbar devices. When these switchable MIMs are introduced into high viscosity polymer matrices, or self-assembled as monolayers onto metal surfaces, both in the form of nanoparticles and flat electrodes, or organised as tightly packed islands of hundreds and thousands of molecules sandwiched between two electrodes, the thermodynamics which characterise their switching remain approximately constant while the kinetics associated with their reset follow an intuitively predictable trend--that is, fast when they are free in solution and sluggish when they are constrained within closely packed monolayers. The importance of seamless interactions and constant feedback between the makers, the measurers and the modellers in establishing the structure-property relationships in these integrated functioning systems cannot be stressed enough as rationalising the many different factors that impact device performance becomes more and more demanding. The choice of electrodes, as well as the self-organised superstructures of the monolayers of switchable MIMs employed in the molecular switch tunnel junctions (MSTJs) associated

  17. Robust quantum state transfer via topologically protected edge channels in dipolar arrays

    NASA Astrophysics Data System (ADS)

    Dlaska, C.; Vermersch, B.; Zoller, P.

    2017-03-01

    We show how to realise quantum state transfer between distant qubits using the chiral edge states of a two-dimensional topological spin system. Our implementation based on Rydberg atoms allows to realise the quantum state transfer protocol in state-of-the-art experimental setups. In particular, we show how to adapt the standard state transfer protocol to make it robust against dispersive and disorder effects.

  18. Dynamics robustness of cascading systems.

    PubMed

    Young, Jonathan T; Hatakeyama, Tetsuhiro S; Kaneko, Kunihiko

    2017-03-01

    A most important property of biochemical systems is robustness. Static robustness, e.g., homeostasis, is the insensitivity of a state against perturbations, whereas dynamics robustness, e.g., homeorhesis, is the insensitivity of a dynamic process. In contrast to the extensively studied static robustness, dynamics robustness, i.e., how a system creates an invariant temporal profile against perturbations, is little explored despite transient dynamics being crucial for cellular fates and are reported to be robust experimentally. For example, the duration of a stimulus elicits different phenotypic responses, and signaling networks process and encode temporal information. Hence, robustness in time courses will be necessary for functional biochemical networks. Based on dynamical systems theory, we uncovered a general mechanism to achieve dynamics robustness. Using a three-stage linear signaling cascade as an example, we found that the temporal profiles and response duration post-stimulus is robust to perturbations against certain parameters. Then analyzing the linearized model, we elucidated the criteria of when signaling cascades will display dynamics robustness. We found that changes in the upstream modules are masked in the cascade, and that the response duration is mainly controlled by the rate-limiting module and organization of the cascade's kinetics. Specifically, we found two necessary conditions for dynamics robustness in signaling cascades: 1) Constraint on the rate-limiting process: The phosphatase activity in the perturbed module is not the slowest. 2) Constraints on the initial conditions: The kinase activity needs to be fast enough such that each module is saturated even with fast phosphatase activity and upstream changes are attenuated. We discussed the relevance of such robustness to several biological examples and the validity of the above conditions therein. Given the applicability of dynamics robustness to a variety of systems, it will provide a

  19. Dynamics robustness of cascading systems

    PubMed Central

    Kaneko, Kunihiko

    2017-01-01

    A most important property of biochemical systems is robustness. Static robustness, e.g., homeostasis, is the insensitivity of a state against perturbations, whereas dynamics robustness, e.g., homeorhesis, is the insensitivity of a dynamic process. In contrast to the extensively studied static robustness, dynamics robustness, i.e., how a system creates an invariant temporal profile against perturbations, is little explored despite transient dynamics being crucial for cellular fates and are reported to be robust experimentally. For example, the duration of a stimulus elicits different phenotypic responses, and signaling networks process and encode temporal information. Hence, robustness in time courses will be necessary for functional biochemical networks. Based on dynamical systems theory, we uncovered a general mechanism to achieve dynamics robustness. Using a three-stage linear signaling cascade as an example, we found that the temporal profiles and response duration post-stimulus is robust to perturbations against certain parameters. Then analyzing the linearized model, we elucidated the criteria of when signaling cascades will display dynamics robustness. We found that changes in the upstream modules are masked in the cascade, and that the response duration is mainly controlled by the rate-limiting module and organization of the cascade’s kinetics. Specifically, we found two necessary conditions for dynamics robustness in signaling cascades: 1) Constraint on the rate-limiting process: The phosphatase activity in the perturbed module is not the slowest. 2) Constraints on the initial conditions: The kinase activity needs to be fast enough such that each module is saturated even with fast phosphatase activity and upstream changes are attenuated. We discussed the relevance of such robustness to several biological examples and the validity of the above conditions therein. Given the applicability of dynamics robustness to a variety of systems, it will provide a

  20. Free-field realisations of the BMS3 algebra and its extensions

    NASA Astrophysics Data System (ADS)

    Banerjee, Nabamita; Jatkar, Dileep P.; Mukhi, Sunil; Neogi, Turmoli

    2016-06-01

    We construct an explicit realisation of the BMS3 algebra with nonzero central charges using holomorphic free fields. This can be extended by the addition of chiral matter to a realisation having arbitrary values for the two independent central charges. Via the introduction of additional free fields, we extend our construction to the minimally supersymmetric BMS3 algebra and to the nonlinear higher-spin BMS3-W3 algebra. We also describe an extended system that realises both the SU(2) current algebra as well as BMS3 via the Wakimoto representation, though in this case introducing a central extension also brings in new non-central operators.

  1. Realising stratified psychiatry using multidimensional signatures and trajectories.

    PubMed

    Joyce, Dan W; Kehagia, Angie A; Tracy, Derek K; Proctor, Jessica; Shergill, Sukhwinder S

    2017-01-18

    outcomes while identifying a small number of trials that could be reanalysed using our proposal. We describe quantitative methods for the development of a multi-dimensional model of clinical state, disorders and trajectories which practically realises stratified psychiatry. We highlight the potential for recovering existing trial data, the implications for stratified psychiatry in trial design and clinical treatment and finally, describe different kinds of probabilistic reasoning tools necessary to implement stratification.

  2. Robust Nanoparticles

    DTIC Science & Technology

    2015-01-21

    advanced the chemis1:Iy of ftmctional nanopruiicles and used these patiicles in advanced materials assembly for the fabrication of nanopatiicle...polymer ligands, and the robustness resulting fi:om ligand cross-linking post- assembly . The project developed a facile evaporative assembly method...used these particles in advanced materials assembly for the fabrication of nanoparticle-based mesostructures. These hybrid materials possess extremely

  3. Some recent progresses in quantum tomography realised at INRIM

    NASA Astrophysics Data System (ADS)

    Piacentini, F.; Goldschmidt, E. A.; Mingolla, Maria G.; Degiovanni, I. P.; Gramegna, M.; Berchera, I. R.; Polyakov, S. V.; Peters, S.; Kück, S.; Taralli, E.; Lolli, L.; Rajteri, M.; Paris, M. G. A.; Migdall, A.; Brida, G.; Genovese, M.

    2013-09-01

    We present some Quantum Tomography related results recently obtained in the Quantum Optics labs of the National Institute of Metrological Research (INRIM). Initially we describe the first experimental implementation of a new protocol for the reconstruction of a photon-number-resolving (PNR) detector's POVM (Positive Operator-Valued Measure): such a protocol, exploiting the strong quantum correlations of an ancillary state, results more robust and efficient than its classical counterparts. The second part of the paper focuses on the quantum characterization of a transition-edge sensor (TES) based PNR detector, i.e. the experimental tomography of the POVM of a TES, with a method based on a quorum of coherent probes: we show the reconstruction of the POVM elements up to 11 detected photons and 100 incoming photons, demonstrating the linearity of such a device. Finally, we present a method for the experimental reconstruction of the modal structure of multimode optical fields exploiting a single measurement of higher-order photon number autocorrelation functions. We show our reconstructions of up to three different modes per optical state, demonstrating the excellent agreement with the theoretical predictions and the robustness of our method itself.

  4. Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patients

    PubMed Central

    George, Angela; Riddell, Daniel; Seal, Sheila; Talukdar, Sabrina; Mahamdallie, Shazia; Ruark, Elise; Cloke, Victoria; Slade, Ingrid; Kemp, Zoe; Gore, Martin; Strydom, Ann; Banerjee, Susana; Hanson, Helen; Rahman, Nazneen

    2016-01-01

    Advances in DNA sequencing have made genetic testing fast and affordable, but limitations of testing processes are impeding realisation of patient benefits. Ovarian cancer exemplifies the potential value of genetic testing and the shortcomings of current pathways to access testing. Approximately 15% of ovarian cancer patients have a germline BRCA1 or BRCA2 mutation which has substantial implications for their personal management and that of their relatives. Unfortunately, in most countries, routine implementation of BRCA testing for ovarian cancer patients has been inconsistent and largely unsuccessful. We developed a rapid, robust, mainstream genetic testing pathway in which testing is undertaken by the trained cancer team with cascade testing to relatives performed by the genetics team. 207 women with ovarian cancer were offered testing through the mainstream pathway. All accepted. 33 (16%) had a BRCA mutation. The result informed management of 79% (121/154) women with active disease. Patient and clinician feedback was very positive. The pathway offers a 4-fold reduction in time and 13-fold reduction in resource requirement compared to the conventional testing pathway. The mainstream genetic testing pathway we present is effective, efficient and patient-centred. It can deliver rapid, robust, large-scale, cost-effective genetic testing of BRCA1 and BRCA2 and may serve as an exemplar for other genes and other diseases. PMID:27406733

  5. Robust trajectory tracking: differential game/cheap control approach

    NASA Astrophysics Data System (ADS)

    Turetsky, Vladimir; Glizer, Valery Y.; Shinar, Josef

    2014-11-01

    A robust trajectory tracking problem is treated in the framework of a zero-sum linear-quadratic differential game of a general type. For the cheap control version of this game, a novel solvability condition is derived. The sufficient condition, guaranteeing that the tracking problem is solved by the optimal strategy of the minimiser in the cheap control game, is established. The boundedness of the time realisations of this strategy is analysed. An illustrative example is presented.

  6. Realising the European network of biodosimetry: RENEB—status quo

    PubMed Central

    Kulka, U.; Ainsbury, L.; Atkinson, M.; Barnard, S.; Smith, R.; Barquinero, J. F.; Barrios, L.; Bassinet, C.; Beinke, C.; Cucu, A.; Darroudi, F.; Fattibene, P.; Bortolin, E.; Monaca, S. Della; Gil, O.; Gregoire, E.; Hadjidekova, V.; Haghdoost, S.; Hatzi, V.; Hempel, W.; Herranz, R.; Jaworska, A.; Lindholm, C.; Lumniczky, K.; M'kacher, R.; Mörtl, S.; Montoro, A.; Moquet, J.; Moreno, M.; Noditi, M.; Ogbazghi, A.; Oestreicher, U.; Palitti, F.; Pantelias, G.; Popescu, I.; Prieto, M. J.; Roch-Lefevre, S.; Roessler, U.; Romm, H.; Rothkamm, K.; Sabatier, L.; Sebastià, N.; Sommer, S.; Terzoudi, G.; Testa, A.; Thierens, H.; Trompier, F.; Turai, I.; Vandevoorde, C.; Vaz, P.; Voisin, P.; Vral, A.; Ugletveit, F.; Wieser, A.; Woda, C.; Wojcik, A.

    2015-01-01

    Creating a sustainable network in biological and retrospective dosimetry that involves a large number of experienced laboratories throughout the European Union (EU) will significantly improve the accident and emergency response capabilities in case of a large-scale radiological emergency. A well-organised cooperative action involving EU laboratories will offer the best chance for fast and trustworthy dose assessments that are urgently needed in an emergency situation. To this end, the EC supports the establishment of a European network in biological dosimetry (RENEB). The RENEB project started in January 2012 involving cooperation of 23 organisations from 16 European countries. The purpose of RENEB is to increase the biodosimetry capacities in case of large-scale radiological emergency scenarios. The progress of the project since its inception is presented, comprising the consolidation process of the network with its operational platform, intercomparison exercises, training activities, proceedings in quality assurance and horizon scanning for new methods and partners. Additionally, the benefit of the network for the radiation research community as a whole is addressed. PMID:25205835

  7. Realising the European network of biodosimetry: RENEB-status quo.

    PubMed

    Kulka, U; Ainsbury, L; Atkinson, M; Barnard, S; Smith, R; Barquinero, J F; Barrios, L; Bassinet, C; Beinke, C; Cucu, A; Darroudi, F; Fattibene, P; Bortolin, E; Monaca, S Della; Gil, O; Gregoire, E; Hadjidekova, V; Haghdoost, S; Hatzi, V; Hempel, W; Herranz, R; Jaworska, A; Lindholm, C; Lumniczky, K; M'kacher, R; Mörtl, S; Montoro, A; Moquet, J; Moreno, M; Noditi, M; Ogbazghi, A; Oestreicher, U; Palitti, F; Pantelias, G; Popescu, I; Prieto, M J; Roch-Lefevre, S; Roessler, U; Romm, H; Rothkamm, K; Sabatier, L; Sebastià, N; Sommer, S; Terzoudi, G; Testa, A; Thierens, H; Trompier, F; Turai, I; Vandevoorde, C; Vaz, P; Voisin, P; Vral, A; Ugletveit, F; Wieser, A; Woda, C; Wojcik, A

    2015-04-01

    Creating a sustainable network in biological and retrospective dosimetry that involves a large number of experienced laboratories throughout the European Union (EU) will significantly improve the accident and emergency response capabilities in case of a large-scale radiological emergency. A well-organised cooperative action involving EU laboratories will offer the best chance for fast and trustworthy dose assessments that are urgently needed in an emergency situation. To this end, the EC supports the establishment of a European network in biological dosimetry (RENEB). The RENEB project started in January 2012 involving cooperation of 23 organisations from 16 European countries. The purpose of RENEB is to increase the biodosimetry capacities in case of large-scale radiological emergency scenarios. The progress of the project since its inception is presented, comprising the consolidation process of the network with its operational platform, intercomparison exercises, training activities, proceedings in quality assurance and horizon scanning for new methods and partners. Additionally, the benefit of the network for the radiation research community as a whole is addressed.

  8. Liverpool Bay Development - oil spill response strategy and its realisation

    SciTech Connect

    Gilliver, R.E.; Methven, J.O.; Nicholls, M.R.

    1996-12-31

    Robust contingency oil spill response arrangements are a prerequisite of nearshore oilfield developments. The Liverpool Bay Development (LBD) represents the greatest UK challenge to date in this regard. This paper describes the development of BHP Petroleum E/R/A/ME Region`s LBD oil spill response strategy and how it was possible to implement this strategy in a very cost effective way. The strategy was based initially on the field Environmental Impact Assessments, which had identified oil spill hazards and risks based on industry data. Additional studies and tests defined credible oil spill events, specific oil properties and coastal impacts. The types, levels and location of response requirements offshore and onshore were then evaluated - we had our strategy. A series of in-house brain storm sessions reviewed all possible means of achieving the strategy. LBD was unique: a 4 field nearshore development with offshore crude storage and offloading. Novel solutions should be possible, resulting in a more cost effective implementation of the response strategy. Using multi-function vessels was a recurring theme - oil spill response arrangements should not be considered in isolation but together with other marine support services. A crucial step was to realize accepted practices were based on single well or single field scenarios. The company successfully opened a debate within the industry and government agencies on existing UK Regulations governing oil spill recovery, resulting in drafted, more practical Regulations and Guidelines. A shortlist of possible vessel scenarios was then prepared. These were costed and tested against the response strategy by risk analysis, checking double jeopardy cover for all marine support services. Government Agencies were consulted closely. This was particularly important because of the novel nature of the proposals. Their considered and positive responses enabled us to go forward with the most cost effective acceptable solution.

  9. Realising Graduate Attributes in the Research Degree: The Role of Peer Support Groups

    ERIC Educational Resources Information Center

    Stracke, Elke; Kumar, Vijay

    2014-01-01

    This paper discusses the role of peer support groups (PSGs) in realising graduate attributes in the research degree. The literature indicates that top-down embedding of graduate attributes has met with only limited success. By taking a bottom-up approach, this paper shows that PSGs offer an opportunity to improve the graduate attribute outcomes of…

  10. Changing Policy Levers under the Neoliberal State: Realising Coalition Policy on Education and Social Mobility

    ERIC Educational Resources Information Center

    Riddell, Richard

    2013-01-01

    Taking recent policy on education and social mobility as a working example, this article examines developments in the mechanisms for realising policy over the past ten years, as indicative of changes in the neoliberal state. This initial analysis suggests that, despite similarities in the process of policy formation before and after the General…

  11. Realising Graduate Attributes in the Research Degree: The Role of Peer Support Groups

    ERIC Educational Resources Information Center

    Stracke, Elke; Kumar, Vijay

    2014-01-01

    This paper discusses the role of peer support groups (PSGs) in realising graduate attributes in the research degree. The literature indicates that top-down embedding of graduate attributes has met with only limited success. By taking a bottom-up approach, this paper shows that PSGs offer an opportunity to improve the graduate attribute outcomes of…

  12. Changing Policy Levers under the Neoliberal State: Realising Coalition Policy on Education and Social Mobility

    ERIC Educational Resources Information Center

    Riddell, Richard

    2013-01-01

    Taking recent policy on education and social mobility as a working example, this article examines developments in the mechanisms for realising policy over the past ten years, as indicative of changes in the neoliberal state. This initial analysis suggests that, despite similarities in the process of policy formation before and after the General…

  13. Robust attitude tracking control of small-scale unmanned helicopter

    NASA Astrophysics Data System (ADS)

    Wang, Xiafu; Chen, You; Lu, Geng; Zhong, Yisheng

    2015-06-01

    Robust attitude control problem for small-scale unmanned helicopters is investigated to improve attitude control performances of roll and pitch channels under both small and large amplitude manoeuvre flight conditions. The model of the roll or pitch angular dynamics is regarded as a nominal single-input single-output linear system with equivalent disturbances which contain nonlinear uncertainties, coupling-effects, parameter perturbations, and external disturbances. Based on the signal compensation method, a robust controller is designed with two parts: a proportional-derivative controller and a robust compensator. The designed controller is linear and time-invariant, so it can be easily realised. The robust properties of the closed-loop system are proven. According to the ADS-33E-PRF military rotorcraft standard, the controller can achieve top control performances. Experimental results demonstrate the effectiveness of the proposed control strategy.

  14. How Fast Is Fast?

    ERIC Educational Resources Information Center

    Korn, Abe

    1994-01-01

    Presents an activity that enables students to answer for themselves the question of how fast a body must travel before the nonrelativistic expression must be replaced with the correct relativistic expression by deciding on the accuracy required in describing the kinetic energy of a body. (ZWH)

  15. Realising effective theories of tribrid inflation: are there effects from messenger fields?

    NASA Astrophysics Data System (ADS)

    Antusch, Stefan; Nolde, David

    2015-09-01

    Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUT and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.

  16. Realising effective theories of tribrid inflation: are there effects from messenger fields?

    SciTech Connect

    Antusch, Stefan; Nolde, David E-mail: david.nolde@unibas.ch

    2015-09-01

    Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUT and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.

  17. Identification and Assessment of Impacts On The Previous Environment To The Freeway Section Realisation

    NASA Astrophysics Data System (ADS)

    Iddir, R.; Laradi, N.

    The development of the automotive circulation and the road, indispensable infras- tructures, to contribute to the economic development, sometimes drags important nui- sances on the environment, that will emerge at the time of the realisation of the work. Pollution's given out by the circulation are responsible of about 30 to 40% of gases to greenhouse effect, in the particular topographic and meteorological situations, they can aggravate the industrial pollution and can conduct to the ominous effects on the health of populations and physico chemical attacks of building facades. The analy- sis of impacts consists in discovering the eventual repercussions of the project on the different considered solutions, while appreciating the relative importance of their re- spective effects. So we signalled that the realisation of this road infrastructure to the level of the valley will drag repercussions on the natural resources as well as on the harnessing of the site. Finally among the direct aftermath's of the realisation of the project is the pollution of hydrous resources can cause disruptions on the feeding in drinking water or the irrigation, concerning a good part of the population of the val- ley. The acoustic and atmospheric pollution will be important and of a very dangerous degree in the City.

  18. Realising effective theories of tribrid inflation: are there effects from messenger fields?

    SciTech Connect

    Antusch, Stefan; Nolde, David

    2015-09-22

    Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUT and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.

  19. Fast and robust generation of high-resolution genetic maps in grapevine interspecific hybrid half-sib families using the HetMappS pipeline and R/qtl

    USDA-ARS?s Scientific Manuscript database

    Genotyping-by-sequencing (GBS) provides an opportunity for fast and inexpensive generation of unbiased SNPs. However, due to its low coverage, GBS SNPs have a higher proportion of missing data and genotyping error associated with heterozygote undercalling than traditional genotyping platforms. These...

  20. Robust vessel segmentation

    NASA Astrophysics Data System (ADS)

    Bock, Susanne; Kühnel, Caroline; Boskamp, Tobias; Peitgen, Heinz-Otto

    2008-03-01

    In the context of cardiac applications, the primary goal of coronary vessel analysis often consists in supporting the diagnosis of vessel wall anomalies, such as coronary plaque and stenosis. Therefore, a fast and robust segmentation of the coronary tree is a very important but challenging task. We propose a new approach for coronary artery segmentation. Our method is based on an earlier proposed progressive region growing. A new growth front monitoring technique controls the segmentation and corrects local leakage by retrospective detection and removal of leakage artifacts. While progressively reducing the region growing threshold for the whole image, the growing process is locally analyzed using criteria based on the assumption of tubular, gradually narrowing vessels. If a voxel volume limit or a certain shape constraint is exceeded, the growing process is interrupted. Voxels affected by a failed segmentation are detected and deleted from the result. To avoid further processing at these positions, a large neighborhood is blocked for growing. Compared to a global region growing without local correction, our new local growth control and the adapted correction can deal with contrast decrease even in very small coronary arteries. Furthermore, our algorithm can efficiently handle noise artifacts and partial volume effects near the myocardium. The enhanced segmentation of more distal vessel parts was tested on 150 CT datasets. Furthermore, a comparison between the pure progressive region growing and our new approach was conducted.

  1. Donor/Acceptor Mixed Self-Assembled Monolayers for Realising a Multi-Redox-State Surface.

    PubMed

    Casado-Montenegro, Javier; Marchante, Elena; Crivillers, Núria; Rovira, Concepció; Mas-Torrent, Marta

    2016-06-17

    Mixed molecular self-assembled monolayers (SAMs) on gold, based on two types of electroactive molecules, that is, electron-donor (ferrocene) and electron-acceptor (anthraquinone) molecules, are prepared as an approach to realise surfaces exhibiting multiple accessible redox states. The SAMs are investigated in different electrolyte media. The nature of these media has a strong impact on the types of redox processes that take place and on the redox potentials. Under optimised conditions, surfaces with three redox states are achieved. Such states are accessible in a relatively narrow potential window in which the SAMs on gold are stable. This communication elucidates the key challenges in fabricating bicomponent SAMs as electrochemical switches.

  2. Realisation de composants tout-fibre passifs bases sur des fibres optiques a deux coeurs

    NASA Astrophysics Data System (ADS)

    Jacob Poulin, Anne C.

    2002-01-01

    Les composants passifs tout-optique sont des elements de choix dans les systemes de communications optiques. Cette these presente l'utilisation experimentale de fibres a deux coeurs dissimilaires pour la realisation de filtres passe-bande. Les fibres a deux coeurs ont la particularite de favoriser un couplage d'un coeur a l'autre a intervalles reguliers lorsque les coeurs sont exactement identiques. Dans le cas ou une legere difference apparait, ce couplage est rapidement reduit a zero. La premiere partie de la these montre comment, par l'emploi d'une geometrie de fibre appropriee, il est possible de compenser cette desyntonisation et de fabriquer des coupleurs 100%. Les filtres obtenus ayant toutefois une largeur de bande trop grande pour les besoins du marche des communications optiques, il est montre dans la deuxieme partie de la these comment, en alliant la technologie des reseaux de Bragg avec celle des coupleurs, il est possible de realiser des filtres operant en transmission et possedant d'excellentes caracteristiques spectrales, toujours avec ces memes fibres a deux coeurs.

  3. Synthesis of robust controllers

    NASA Technical Reports Server (NTRS)

    Marrison, Chris

    1993-01-01

    At the 1990 American Controls Conference a benchmark problem was issued as a challenge for designing robust compensators. Many compensators were presented in response to the problem. In previous work Stochastic Robustness Analysis (SRA) was used to compare these compensators. In this work SRA metrics are used as guides to synthesize robust compensators, using the benchmark problem as an example.

  4. Predictions of realised fecundity and spawning time in Norwegian spring-spawning herring ( Clupea harengus)

    NASA Astrophysics Data System (ADS)

    Óskarsson, G. J.; Kjesbu, O. S.; Slotte, A.

    2002-08-01

    Maturing Norwegian spring-spawning (NSS) herring, Clupea harengus, were collected for reproductive analyses along the Norwegian coast prior to the spawning seasons of 1997-2000. Over this time period there was a marked change in weight (W) at length (TL) with 1998 showing extremely low values and 2000 high values in a historical perspective. Potential fecundity, amounting to about 20 000-100 000 developing (vitellogenic) oocytes per fish and positively related to fish size, increased significantly with fish condition. Relative somatic potential fecundity (RF P, number of oocytes per g ovary-free body weight) in NSS herring was found to vary by 35-55% between years. Unexpectedly, females in 2000 showed low RF P-values, possibly due to negative feedback from previous reproductive investments at low condition. A clear threshold value for Fulton's condition factor, K (K=100×W/TL 3), of 0.65-0.70 existed below which there was considerable atresia (resorption of vitellogenic oocytes). Thus, these components of the spawning stock, amounting to 1-46% in the period 1980-1999, obviously contributed relatively little to the total egg production. This was confirmed by low ovary weights and examples of delayed oocyte development in these individuals. An up-to-date atresia model is presented. The established oocyte growth curve, and to a lesser degree the assumed atretic oocytic turnover rate, was critical for the estimation of realised fecundity (number of eggs spawned). Modelled realised fecundity was significantly below observed potential fecundity. Females that had migrated the shortest distance from the over-wintering area, Vestfjorden, northern Norway, were in the poorest condition, had the least developed oocytes and the lowest potential and realised fecundities. In agreement with previously published studies on temporal and spatial changes in gonad weights, those females reaching the main spawning grounds in the south-western part of the coast (Møre) were the most

  5. Identification of Francisella tularensis by whole-cell matrix-assisted laser desorption ionization-time of flight mass spectrometry: fast, reliable, robust, and cost-effective differentiation on species and subspecies levels.

    PubMed

    Seibold, E; Maier, T; Kostrzewa, M; Zeman, E; Splettstoesser, W

    2010-04-01

    Francisella tularensis, the causative agent of tularemia, is a potential agent of bioterrorism. The phenotypic discrimination of closely related, but differently virulent, Francisella tularensis subspecies with phenotyping methods is difficult and time-consuming, often producing ambiguous results. As a fast and simple alternative, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) was applied to 50 different strains of the genus Francisella to assess its ability to identify and discriminate between strains according to their designated species and subspecies. Reference spectra from five representative strains of Francisella philomiragia, Francisella tularensis subsp. tularensis, Francisella tularensis subsp. holarctica, Francisella tularensis subsp. mediasiatica, and Francisella tularensis subsp. novicida were established and evaluated for their capability to correctly identify Francisella species and subspecies by matching a collection of spectra from 45 blind-coded Francisella strains against a database containing the five reference spectra and 3,287 spectra from other microorganisms. As a reference method for identification of strains from the genus Francisella, 23S rRNA gene sequencing was used. All strains were correctly identified, with both methods showing perfect agreement at the species level as well as at the subspecies level. The identification of Francisella strains by MALDI-TOF MS and subsequent database matching was reproducible using biological replicates, different culture media, different cultivation times, different serial in vitro passages of the same strain, different preparation protocols, and different mass spectrometers.

  6. Fast Reactors

    NASA Astrophysics Data System (ADS)

    Esposito, S.; Pisanti, O.

    The following sections are included: * Elementary Considerations * The Integral Equation to the Neutron Distribution * The Critical Size for a Fast Reactor * Supercritical Reactors * Problems and Exercises

  7. Atrial Fibrillation Management Strategies in Routine Clinical Practice: Insights from the International RealiseAF Survey

    PubMed Central

    Chiang, Chern-En; Naditch-Brûlé, Lisa; Brette, Sandrine; Silva-Cardoso, José; Gamra, Habib; Murin, Jan; Zharinov, Oleg J.; Steg, Philippe Gabriel

    2016-01-01

    Background Atrial fibrillation (AF) can be managed with rhythm- or rate-control strategies. There are few data from routine clinical practice on the frequency with which each strategy is used and their correlates in terms of patients’ clinical characteristics, AF control, and symptom burden. Methods RealiseAF was an international, cross-sectional, observational survey of 11,198 patients with AF. The aim of this analysis was to describe patient profiles and symptoms according to the AF management strategy used. A multivariate logistic regression identified factors associated with AF management strategy at the end of the visit. Results Among 10,497 eligible patients, 53.7% used a rate-control strategy, compared with 34.5% who used a rhythm-control strategy. In 11.8% of patients, no clear strategy was stated. The proportion of patients with AF-related symptoms (EHRA Class > = II) was 78.1% (n = 4396/5630) for those using a rate-control strategy vs. 67.8% for those using a rhythm-control strategy (p<0.001). Multivariate logistic regression analysis revealed that age <75 years or the paroxysmal or persistent form of AF favored the choice of a rhythm-control strategy. A change in strategy was infrequent, even in patients with European Heart Rhythm Association (EHRA) Class > = II. Conclusions In the RealiseAF routine clinical practice survey, rate control was more commonly used than rhythm control, and a change in strategy was uncommon, even in symptomatic patients. In almost 12% of patients, no clear strategy was stated. Physician awareness regarding optimal management strategies for AF may be improved. PMID:26800084

  8. Realising the dream of becoming a nurse: Underrepresented BSc nursing students experiences.

    PubMed

    O'Brien, Brid; Graham, Margaret M; O'Sullivan, Deirdre

    2017-07-01

    This paper describes the experiences of underrepresented BSc nursing students in realising the dream of becoming a nurse in one university. In the past ten years, pre-registration nurse education has become established within higher education in Ireland. This development includes promoting access and inclusion of students from traditionally underrepresented groups in higher education. A third of nursing students currently access places on programmes through routes specifically designed for underrepresented groups. A qualitative descriptive study design provided an opportunity for student voices to be heard. Ethical approval was sought and granted. Eleven students were interviewed nearing completion of a four year BSc Nursing programme. Data analysis followed a thematic approach, in generating themes. Three themes emerged from the data: taking the first steps; finding a way and getting through. Findings highlight participants' challenges in balancing study, clinical practice and family life in achieving and realising their dream of becoming a nurse. This study illustrates the nature and complexities of participants' experiences throughout the BSc Nursing programmes towards becoming university graduates, eligible for registration as a nurse. Students from underrepresented groups bring rich and diverse life experiences in preparation for and becoming caring practitioners. It highlights the individuality within participants' experiences and draws attention to the value of personalised support for students. An opportunity to encourage the development of emotional intelligence needs to be fostered within nurse education programmes. Creating positive learning environments is critical to supporting student understanding of compassionate patient centred care. Findings have relevance for global curriculum design and structures to support individual student centred engagement. Further research is required to consider how best to support students from underrepresented groups

  9. Brownfields to green fields: Realising wider benefits from practical contaminant phytomanagement strategies.

    PubMed

    Cundy, A B; Bardos, R P; Puschenreiter, M; Mench, M; Bert, V; Friesl-Hanl, W; Müller, I; Li, X N; Weyens, N; Witters, N; Vangronsveld, J

    2016-12-15

    Gentle remediation options (GROs) are risk management strategies or technologies involving plant (phyto-), fungi (myco-), and/or bacteria-based methods that result in a net gain (or at least no gross reduction) in soil function as well as effective risk management. GRO strategies can be customised along contaminant linkages, and can generate a range of wider economic, environmental and societal benefits in contaminated land management (and in brownfields management more widely). The application of GROs as practical on-site remedial solutions is still limited however, particularly in Europe and at trace element (typically metal and metalloid) contaminated sites. This paper discusses challenges to the practical adoption of GROs in contaminated land management, and outlines the decision support tools and best practice guidance developed in the European Commission FP7-funded GREENLAND project aimed at overcoming these challenges. The GREENLAND guidance promotes a refocus from phytoremediation to wider GROs- or phyto-management based approaches which place realisation of wider benefits at the core of site design, and where gentle remediation technologies can be applied as part of integrated, mixed, site risk management solutions or as part of "holding strategies" for vacant sites. The combination of GROs with renewables, both in terms of biomass generation but also with green technologies such as wind and solar power, can provide a range of economic and other benefits and can potentially support the return of low-level contaminated sites to productive usage, while combining GROs with urban design and landscape architecture, and integrating GRO strategies with sustainable urban drainage systems and community gardens/parkland (particularly for health and leisure benefits), has large potential for triggering GRO application and in realising wider benefits in urban and suburban systems. Quantifying these wider benefits and value (above standard economic returns) will be

  10. Robust Adaptive Control

    NASA Technical Reports Server (NTRS)

    Narendra, K. S.; Annaswamy, A. M.

    1985-01-01

    Several concepts and results in robust adaptive control are are discussed and is organized in three parts. The first part surveys existing algorithms. Different formulations of the problem and theoretical solutions that have been suggested are reviewed here. The second part contains new results related to the role of persistent excitation in robust adaptive systems and the use of hybrid control to improve robustness. In the third part promising new areas for future research are suggested which combine different approaches currently known.

  11. Robust Control Systems.

    DTIC Science & Technology

    1981-12-01

    Controller ................... 38 Sampled-Data Performance Analysis ............. 44 Doyle and Stein Technique in Discrete-Time Systems - 1...48 Doyle and Stein Technique in Discretd-Time System.s - 2 ................................. 50 Enhancing Robustness of... Technique Extended to Sampled-Data Controllers ................ 73 G715 Robustness Enhancement by Directly D"?C TAB E

  12. Robust Critical Point Detection

    SciTech Connect

    Bhatia, Harsh

    2016-07-28

    Robust Critical Point Detection is a software to compute critical points in a 2D or 3D vector field robustly. The software was developed as a part of the author's work at the lab as a Phd student under Livermore Scholar Program (now called Livermore Graduate Scholar Program).

  13. Mechanisms for Robust Cognition

    ERIC Educational Resources Information Center

    Walsh, Matthew M.; Gluck, Kevin A.

    2015-01-01

    To function well in an unpredictable environment using unreliable components, a system must have a high degree of robustness. Robustness is fundamental to biological systems and is an objective in the design of engineered systems such as airplane engines and buildings. Cognitive systems, like biological and engineered systems, exist within…

  14. Mechanisms for Robust Cognition

    ERIC Educational Resources Information Center

    Walsh, Matthew M.; Gluck, Kevin A.

    2015-01-01

    To function well in an unpredictable environment using unreliable components, a system must have a high degree of robustness. Robustness is fundamental to biological systems and is an objective in the design of engineered systems such as airplane engines and buildings. Cognitive systems, like biological and engineered systems, exist within…

  15. External Quality Assessment of Non-University Study Programmes Which Were Developed and Submitted for Realisation: Experience and Problems

    ERIC Educational Resources Information Center

    Zibeniene, Gintaute

    2004-01-01

    The author analyzes the nature of study programme assessment with regard to the assurance of study quality. The organisation of the assessment process of the non-university study programmes which were developed and submitted for realisation in Lithuania and other countries is also presented and compared. It is being analysed whether it is possible…

  16. Realising the Potential of New Technology? Assessing the Legacy of New Labour's ICT Agenda 1997-2007

    ERIC Educational Resources Information Center

    Selwyn, Neil

    2008-01-01

    "Realising the potential of new technology" was one of the central educational themes of New Labour's 1997 election manifesto, with "information and communications technology" (ICT) established subsequently as a prominent feature of the Blair administration policy portfolio. As such New Labour can claim rightly to have made an…

  17. The Impact of a Values Education Programme for Adolescent Romanies in Spain on Their Feelings of Self-Realisation

    ERIC Educational Resources Information Center

    Soriano, Encarnacion; Franco, Clemente; Sleeter, Christine

    2011-01-01

    This study analysed the effects a values education programme can have on the feelings of self-realisation, self-concept and self-esteem of Romany adolescents in southern Spain. To do this, an experimental group received a values education intervention but a control group did not. The intervention programme was adapted to the Romany culture. The…

  18. Realisation of Strategic Leadership in Leadership Teams' Work as Experienced by the Leadership Team Members of Basic Education Schools

    ERIC Educational Resources Information Center

    Lahtero, Tapio Juhani; Kuusilehto-Awale, Lea

    2013-01-01

    This article introduces a quantitative research into how the leadership team members of 49 basic education schools in the city of Vantaa, Finland, experienced the realisation of strategic leadership in their leadership teams' work. The data were collected by a survey of 24 statements, rated on a five-point Likert scale, and analysed with the…

  19. Realisation of Strategic Leadership in Leadership Teams' Work as Experienced by the Leadership Team Members of Basic Education Schools

    ERIC Educational Resources Information Center

    Lahtero, Tapio Juhani; Kuusilehto-Awale, Lea

    2013-01-01

    This article introduces a quantitative research into how the leadership team members of 49 basic education schools in the city of Vantaa, Finland, experienced the realisation of strategic leadership in their leadership teams' work. The data were collected by a survey of 24 statements, rated on a five-point Likert scale, and analysed with the…

  20. Realising the Potential of New Technology? Assessing the Legacy of New Labour's ICT Agenda 1997-2007

    ERIC Educational Resources Information Center

    Selwyn, Neil

    2008-01-01

    "Realising the potential of new technology" was one of the central educational themes of New Labour's 1997 election manifesto, with "information and communications technology" (ICT) established subsequently as a prominent feature of the Blair administration policy portfolio. As such New Labour can claim rightly to have made an…

  1. The Impact of a Values Education Programme for Adolescent Romanies in Spain on Their Feelings of Self-Realisation

    ERIC Educational Resources Information Center

    Soriano, Encarnacion; Franco, Clemente; Sleeter, Christine

    2011-01-01

    This study analysed the effects a values education programme can have on the feelings of self-realisation, self-concept and self-esteem of Romany adolescents in southern Spain. To do this, an experimental group received a values education intervention but a control group did not. The intervention programme was adapted to the Romany culture. The…

  2. Realisation d'un detecteur de radioactivite pour un systeme microfluidique

    NASA Astrophysics Data System (ADS)

    Girard Baril, Frederique

    Pour etablir le comportement pharmacocinetique de nouveaux radiotraceurs en imagerie moleculaire, il est necessaire d'approfondir l'analyse realisee a partir d'une image par l'ajout d'une mesure dynamique de la radioactivite dans le sang. L'Universite de Sherbrooke developpe presentement une plateforme microfluidique d'echantillonnage et d'analyse permettant la mesure de la radioactivite du plasma en temps reel. L'objectif du present projet de maitrise etait de realiser le composant optoelectronique responsable de la detection des positrons et de l'integrer a la puce microfluidique. L'option retenue a ete l'utilisation de photodiodes PIN en silicium. Un procede de fabrication, ainsi qu'une serie de photomasques ont ete developpes afin de produire une premiere iteration de prototypes. Les detecteurs ont ete concus de maniere a optimiser leur sensibilite en fonction du type de rayonnement a detecter. En effet, la region de detection doit etre suffisamment epaisse et sensible pour absorber le maximum de particules energetiques. Egalement, il est essentiel de minimiser le courant de fuite en noirceur afin d'obtenir un photocourant directement proportionnel a l'energie des radiations incidentes. Les caracteristiques electriques obtenues avec les premiers detecteurs ont ete demontrees proches des performances de detecteurs commerciaux similaires. De plus, il a ete possible d'integrer un canal microfluidique au substrat contenant les photodiodes et d'en realiser l'encapsulation sans alterer les performances electriques initiales des detecteurs. Une courbe de l'activite radioactive du 18F a ete mesuree, celle-ci se comparant a l'activite theorique associee a ce radioisotope communement utilise en TEP. Enfin, un spectre en energie des emissions radiatives du 18F a ete mesure et compare aux performances de systemes utilisant des photodiodes commerciales. Il a ete demontre que le prototype offrait un rapport signal sur bruit similaire aux systemes bases sur des photodiodes

  3. [Social medicine in medical faculties: realisation of the topic in the specialty "social medicine, occupational health"].

    PubMed

    Behmann, M; Bisson, S; Walter, U

    2011-12-01

    The 9 (th) Revision of German Medical Licensing Regulations for Physicians has come into effect on October 1 (st) 2003. Social medicine was separated into the fields "occupational health, social medicine" and the various cross-sectional modules: epidemiology, biometry, medical computer science; health economics, health-care system, public health; prevention, health promotion; rehabilitation, physical medicine, naturopathic treatment. This paper studies the realisation of teaching in the field social medicine at German medical faculties. The survey was conducted in collaboration with the German Association for Social Medicine and Prevention (DGSMP). A survey was conducted at 38 institutes of 36 German medical faculties. The written questionnaire contained mostly selection items in which chances and barriers of the field were queried with supply items. Information about time scale, general conditions and resources was aked for. On the basis of the guidelines of the DGSMP, the topics to be taught were evaluated concerning their relevance and integration into education. The response rate was 68% (n=26). Social insurance, basic principles, responsibility in the Social Security Code and the different providers were judged as the most important topics. There was a strong demand for lecturing material. 82% (n=18) of the faculties wished to have specific material, for example e-learning, examples, lesson plans, curricula and also textbooks. 91% (n=19) of the faculties requested an exchange of information between the faculties concerning educational contents, motivation of students and e-learning. The realisation of teaching is different between the faculties concerning the number of hours, teaching methods and number of students per year. The motivation of the students is one of the problems, but also the lack of acceptance within the clinic. Specific resources and exchange between the faculties are necessary concerning e-learning, which is offered at only few faculties so

  4. Robustness. [in space systems

    NASA Technical Reports Server (NTRS)

    Ryan, Robert

    1993-01-01

    The concept of rubustness includes design simplicity, component and path redundancy, desensitization to the parameter and environment variations, control of parameter variations, and punctual operations. These characteristics must be traded with functional concepts, materials, and fabrication approach against the criteria of performance, cost, and reliability. The paper describes the robustness design process, which includes the following seven major coherent steps: translation of vision into requirements, definition of the robustness characteristics desired, criteria formulation of required robustness, concept selection, detail design, manufacturing and verification, operations.

  5. Robustness. [in space systems

    NASA Technical Reports Server (NTRS)

    Ryan, Robert

    1993-01-01

    The concept of rubustness includes design simplicity, component and path redundancy, desensitization to the parameter and environment variations, control of parameter variations, and punctual operations. These characteristics must be traded with functional concepts, materials, and fabrication approach against the criteria of performance, cost, and reliability. The paper describes the robustness design process, which includes the following seven major coherent steps: translation of vision into requirements, definition of the robustness characteristics desired, criteria formulation of required robustness, concept selection, detail design, manufacturing and verification, operations.

  6. Inductive robust principal component analysis.

    PubMed

    Bao, Bing-Kun; Liu, Guangcan; Xu, Changsheng; Yan, Shuicheng

    2012-08-01

    In this paper we address the error correction problem that is to uncover the low-dimensional subspace structure from high-dimensional observations, which are possibly corrupted by errors. When the errors are of Gaussian distribution, Principal Component Analysis (PCA) can find the optimal (in terms of least-square-error) low-rank approximation to highdimensional data. However, the canonical PCA method is known to be extremely fragile to the presence of gross corruptions. Recently, Wright et al. established a so-called Robust Principal Component Analysis (RPCA) method, which can well handle grossly corrupted data [14]. However, RPCA is a transductive method and does not handle well the new samples which are not involved in the training procedure. Given a new datum, RPCA essentially needs to recalculate over all the data, resulting in high computational cost. So, RPCA is inappropriate for the applications that require fast online computation. To overcome this limitation, in this paper we propose an Inductive Robust Principal Component Analysis (IRPCA) method. Given a set of training data, unlike RPCA that targets on recovering the original data matrix, IRPCA aims at learning the underlying projection matrix, which can be used to efficiently remove the possible corruptions in any datum. The learning is done by solving a nuclear norm regularized minimization problem, which is convex and can be solved in polynomial time. Extensive experiments on a benchmark human face dataset and two video surveillance datasets show that IRPCA can not only be robust to gross corruptions, but also handle well the new data in an efficient way.

  7. Advances in genetic engineering of the avian genome: "Realising the promise".

    PubMed

    Doran, Timothy J; Cooper, Caitlin A; Jenkins, Kristie A; Tizard, Mark L V

    2016-06-01

    This review provides an historic perspective of the key steps from those reported at the 1st Transgenic Animal Research Conference in 1997 through to the very latest developments in avian transgenesis. Eighteen years later, on the occasion of the 10th conference in this series, we have seen breakthrough advances in the use of viral vectors and transposons to transform the germline via the direct manipulation of the chicken embryo, through to the establishment of PGC cultures allowing in vitro modification, expansion into populations to analyse the genetic modifications and then injection of these cells into embryos to create germline chimeras. We have now reached an unprecedented time in the history of chicken transgenic research where we have the technology to introduce precise, targeted modifications into the chicken genome, ranging from; new transgenes that provide improved phenotypes such as increased resilience to economically important diseases; the targeted disruption of immunoglobulin genes and replacement with human sequences to generate transgenic chickens that express "humanised" antibodies for biopharming; and the deletion of specific nucleotides to generate targeted gene knockout chickens for functional genomics. The impact of these advances is set to be realised through applications in chickens, and other bird species as models in scientific research, for novel biotechnology and to protect and improve agricultural productivity.

  8. Realisation et Applications D'un Laser a Fibre a L'erbium Monofrequence

    NASA Astrophysics Data System (ADS)

    Larose, Robert

    L'incorporation d'ions de terres rares a l'interieur de la matrice de verre d'une fibre optique a permis l'emergence de composants amplificateurs tout-fibre. Le but de cette these consiste d'une part a analyser et a modeliser un tel dispositif et d'autre part, a fabriquer puis a caracteriser un amplificateur et un oscillateur a fibre. A l'aide d'une fibre fortement dopee a l'erbium fabriquee sur demande, on realise un laser a fibre syntonisable qui fonctionne en regime multimodes longitudinaux avec une largeur de raie de 1.5 GHz et egalement comme source monofrequencielle de largeur de raie de 70 kHz. Le laser sert ensuite a caracteriser un reseau de Bragg ecrit par photosensibilite dans une fibre optique. La technique de syntonisation permet aussi l'asservissement au fond d'une resonance de l'acetylene. Le laser garde alors la position centrale de la raie avec une erreur de moins de 1 MHz corrigeant ainsi les derives mecaniques de la cavite.

  9. Design and realisation of leakage channel fibres by the powder-in-tube method

    NASA Astrophysics Data System (ADS)

    Scheuner, J.; Raisin, P.; Pilz, S.; Romano, V.

    2016-04-01

    The applications of fibre lasers demand for increasing power. Limits are set by various nonlinear effects. Leakage channel fibres (LCF) are one approach to this problem. With this type of fibre, most nonlinear effects can, in principle, be mitigated simultaneously by increasing the mode field area and by maintaining the single mode regime. For its implementation, we propose to use the powder-in-tube preform technique. While the microstructure consists of commercial pure silica rods, the surrounding is filled with index-raised aluminum-doped silica oxide granulate. For the fabrication of the latter, we tested two different methods. For the first one, the oxide precursors were mixed in pure powder form. In the other method, the material was produced with the helps of the sol-gel process, where the mixing takes place in liquid phase, thus resulting in an expected improved homogeneity. Prior to the fabrication of a prototype, their feasibility has been tested with the help of a finite-difference method simulation tool (Lumerical MODE Solutions). Two such fibres have been fabricated according to this results. The influence of the granulate mixing method and of the grain size on the homogeneity in refractive index has been tested. Although the produced fibres do not yet show the desired performance, the produced prototypes prove that LCFs can indeed be realised with this approach.

  10. [Prospective study of 420 biopsies realised in patients with duodenal ulcer with positive Helicobacter pylori].

    PubMed

    Khayat, Olfa; Kilani, Afef; Chedly-Debbiche, Achraf; Zeddini, Abdelfattah; Gargouri, Dalila; Kharrat, Jamel; Souissi, Adnene; Ghorbel, Abdel Jabbar; Ben Ayed, Mohamed; Ben Khelifa, Habib

    2006-06-01

    It's a prospective study leaded between September 1997 and july 1999 (23 months ) in 75 patients with duodenal ulcer and positif for Helicobacter pylori. All patients had a first endoscopy with antral, fundic and duodenal biopsies, followed one month later by a second control fibroscopy with biopsies of the same sites. A total of 420 biopsies was realised. Chronic gastritis was evaluated according to sydney system. Patients was divided by randomisation in 4 groups. Every group was received a different therapeutic association. The results was conform to liberation concering activity 80%, intestinal metaplasia 12%. inflammation 100%. Atrophy was observed in 56% of cases, this percentage is variable in literature; chronic gastritis was predominant in antre relatively to fundus (p<0.005). After treatment, a significative fall of Helicobacter pylori and activity and atrophy was established, contrarity to intestinal metaplasia and chronic inflammation witch are persisted. The prevalence of follicular gastritis was 57%. The better rate of ulcer cicatrisation and Helicobacter pylori eradication was respectively of 79% and 66% in group 1 treated by omeprazol, amoxcillin, metronidazol by comparison with the others 3 groups (p<0.005).

  11. Realisation and optical engineering of linear variable bandpass filters in nanoporous anodic alumina photonic crystals.

    PubMed

    Sukarno; Law, Cheryl Suwen; Santos, Abel

    2017-06-08

    We present the first realisation of linear variable bandpass filters in nanoporous anodic alumina (NAA-LVBPFs) photonic crystal structures. NAA gradient-index filters (NAA-GIFs) are produced by sinusoidal pulse anodisation and used as photonic crystal platforms to generate NAA-LVBPFs. The anodisation period of NAA-GIFs is modified from 650 to 850 s to systematically tune the characteristic photonic stopband of these photonic crystals across the UV-visible-NIR spectrum. Then, the nanoporous structure of NAA-GIFs is gradually widened along the surface under controlled conditions by wet chemical etching using a dip coating approach aiming to create NAA-LVBPFs with finely engineered optical properties. We demonstrate that the characteristic photonic stopband and the iridescent interferometric colour displayed by these photonic crystals can be tuned with precision across the surface of NAA-LVBPFs by adjusting the fabrication and etching conditions. Here, we envisage for the first time the combination of the anodisation period and etching conditions as a cost-competitive, facile, and versatile nanofabrication approach that enables the generation of a broad range of unique LVBPFs covering the spectral regions. These photonic crystal structures open new opportunities for multiple applications, including adaptive optics, hyperspectral imaging, fluorescence diagnostics, spectroscopy, and sensing.

  12. 'Lived Islam' in India and Bangladesh: negotiating religion to realise reproductive aspirations.

    PubMed

    Sahu, Biswamitra; Hutter, Inge

    2012-01-01

    This paper seeks to answer the question of how Muslim women interpret and negotiate religion in order to realise their reproductive aspirations. A close reading of lived experiences of 32 Muslim women from a varied educational background yields a wider perspective of the different interpretations of reproductive norms employed by adherents of the same religion (Islam), situated in two countries (India/Bangladesh) and group (majority/minority) contexts. Further, this comparative study yields a deeper understanding of agency that is employed by Muslim participants in each country. Muslim women - both in India and Bangladesh - are not passive followers of religious norms, but have agency to bring change in their own life and take an active role in planning their family, thereby transgressing religious norms in reproductive matters. Muslim women in India exercise their agency by adopting sterilisation - a method proscribed by Islam - without the knowledge of their significant others. Muslim women in Bangladesh use their agency by making a flexible interpretation of Islam in reproductive matters. A lesson learned from this comparative study is the need to remove barriers that prevent the adoption of contraceptives by Muslim minorities in India and to design family planning programmes that takes into account their religious needs.

  13. Realising the Real Benefits of Outsourcing: Measurement Excellence and Its Importance in Achieving Long Term Value

    NASA Astrophysics Data System (ADS)

    Oshri, Ilan; Kotlarsky, Julia

    These days firms are, more than ever, pressed to demonstrate returns on their investment in outsourcing. While the initial returns can always be associated with one-off cost cutting, outsourcing arrangements are complex, often involving inter-related high-value activities, which makes the realisation of long-term benefits from outsourcing ever more challenging. Executives in client firms are no longer satisfied with the same level of service delivery through the outsourcing lifecycle. They seek to achieve business transformation and innovation in their present and future services, beyond satisfying service level agreements (SLAs). Clearly the business world is facing a new challenge: an outsourcing delivery system of high-value activities that demonstrates value over time and across business functions. However, despite such expectations, many client firms are in the dark when trying to measure and quantify the return on outsourcing investments: results of this research show that less than half of all CIOs and CFOs (43%) have attempted to calculate the financial impact of outsourcing to their bottom line, indicating that the financial benefits are difficult to quantify (51%).

  14. Robust Active Portfolio Management

    DTIC Science & Technology

    2006-11-27

    the Markowitz mean-variance model led to development of the Capital Asset Pricing Model ( CAPM ) for asset pricing [35, 29, 23] which remains one of the...active portfolio management. Our model uses historical returns and equilibrium expected returns predicted by the CAPM to identify assets that are...we construct robust models for active portfolio management in a market with transaction costs. The goal of these robust models is to control the impact

  15. Structurally robust biological networks

    PubMed Central

    2011-01-01

    Background The molecular circuitry of living organisms performs remarkably robust regulatory tasks, despite the often intrinsic variability of its components. A large body of research has in fact highlighted that robustness is often a structural property of biological systems. However, there are few systematic methods to mathematically model and describe structural robustness. With a few exceptions, numerical studies are often the preferred approach to this type of investigation. Results In this paper, we propose a framework to analyze robust stability of equilibria in biological networks. We employ Lyapunov and invariant sets theory, focusing on the structure of ordinary differential equation models. Without resorting to extensive numerical simulations, often necessary to explore the behavior of a model in its parameter space, we provide rigorous proofs of robust stability of known bio-molecular networks. Our results are in line with existing literature. Conclusions The impact of our results is twofold: on the one hand, we highlight that classical and simple control theory methods are extremely useful to characterize the behavior of biological networks analytically. On the other hand, we are able to demonstrate that some biological networks are robust thanks to their structure and some qualitative properties of the interactions, regardless of the specific values of their parameters. PMID:21586168

  16. Fast valve

    SciTech Connect

    Van Dyke, William J.

    1992-01-01

    A fast valve is disclosed that can close on the order of 7 milliseconds. It is closed by the force of a compressed air spring with the moving parts of the valve designed to be of very light weight and the valve gate being of wedge shaped with O-ring sealed faces to provide sealing contact without metal to metal contact. The combination of the O-ring seal and an air cushion create a soft final movement of the valve closure to prevent the fast air acting valve from having a harsh closing.

  17. Fast valve

    DOEpatents

    Van Dyke, W.J.

    1992-04-07

    A fast valve is disclosed that can close on the order of 7 milliseconds. It is closed by the force of a compressed air spring with the moving parts of the valve designed to be of very light weight and the valve gate being of wedge shaped with O-ring sealed faces to provide sealing contact without metal to metal contact. The combination of the O-ring seal and an air cushion create a soft final movement of the valve closure to prevent the fast air acting valve from having a harsh closing. 4 figs.

  18. Project FAST.

    ERIC Educational Resources Information Center

    Essexville-Hampton Public Schools, MI.

    Described are components of Project FAST (Functional Analysis Systems Training) a nationally validated project to provide more effective educational and support services to learning disordered children and their regular elementary classroom teachers. The program is seen to be based on a series of modules of delivery systems ranging from mainstream…

  19. Fast CRCs

    DTIC Science & Technology

    2009-10-01

    or any other computing topic, please visit our Digital Library at www.computer.org/publications/ dlib . NGUYEN: FAST CRCS 1331 Authorized licensed use... Library at http://doi.ieeecomputersociety.org/10.1109/ TC.2009.83. The notation ðk; l; dÞ denotes a systematic code with k ¼ the total bit length of

  20. Realising new health technologies: problems of regulating human stem cells in the USA.

    PubMed

    Warren-Jones, Amanda

    2012-01-01

    Stem cell technology holds the promise of radically changing medicine through the provision of better disease models; the creation of tissue, cells, and organs for therapeutic uses; and the increased personalisation of healthcare. However, the degree to which any of these developments can be realised in the USA rests upon how effective the regulatory environment is in nurturing the technology to market. This article assesses the regulation in terms of its ability to minimise factors which erode the public interest in developing medical innovations (abuse) and promoting them to the market. This requires an overarching review of patent law (and how it fits with anti-trust and contract law); as well as the general regulation of innovation through ethical review, clinical trials, market authorisation, post-market oversight; government lead regulation of stem cells; and finally incorporating the impact of self-regulation by industry. From this assessment, it becomes possible to appreciate that the optimal system of regulation is reliant upon the gentle tweaking of many factors, rather than the wholesale revision of only a few. It also becomes possible to identify that individual tools of regulation have varying impacts. For example, the patent system may be the most open to abuse by individual companies, but as a regulatory framework it has the most mechanisms for dealing with such abuses. However, the biggest impact upon curtailing abuse derives from the self-regulation of the industry. Conversely, government led regulation is open to abuse from political agendas, but it has the greatest capacity to nurture innovation productively.

  1. Realising skilled companionship in nursing: a utopian idea or difficult challenge?

    PubMed

    Dierckx de Casterlé, Bernadette

    2015-11-01

    The question being considered in this discussion article is whether nurses' practice can be usefully characterised in terms of skilled companionship. A nurse's role might be characterised as one of a 'skilled companion,' a concept that brings together the scientific and moral basis of nursing practice. It is this focus on integrating both 'skill' and 'companionship' characteristics of nurses' practice that largely determines their effectiveness as care providers and their specific contribution to health care outcomes. Discursive article that invites readers to explore and arrive at a more comprehensive understanding of nurses' daily practice, one from an ethical perspective that is based on empirical data from the study of patients' caring experiences, nurses' caring experiences and nurses' ethical practice in daily care. Research in this era of health care highlights an important dilemma that the nursing profession is confronted with daily: realising nurses' role as a skilled companion in an environment where this concept of nursing care is discouraged, or even thwarted. Although the ethical dimension is explicitly and universally recognised as a core dimension of nursing care, research clearly highlights nurses' difficulties in translating this element into daily practice. Most disturbing in these findings is that both patients and nurses feel compelled to reach a compromise to 'survive' in this often-chaotic caring environment. It appears today that nurses' intrinsic strengths and potential are largely underutilised in daily practice. More than ever, the nursing profession is challenged to reflect on the future position, aspirations and responsibilities of nurses, to make clear choices, and to act accordingly. Viewing and implementing the nurse's role as one of a skilled companion promise better health care delivery in a postmodern world. © 2015 John Wiley & Sons Ltd.

  2. Multiparticle production in the large λ n limit: realising Higgsplosion in a scalar QFT

    NASA Astrophysics Data System (ADS)

    Khoze, Valentin V.

    2017-06-01

    In a scalar theory which we use as a simplified model for the Higgs sector, we adopt the semiclassical formalism of Son for computations of n-particle production cross-sections in the high-multiplicity n → ∞ weak-coupling λ → 0 regime with the value of λ n held fixed and large. The approach relies on the use of singular classical solutions to a certain boundary value problem. In the past this formalism has been successfully used and verified in computations of perturbative multi-particle processes at tree-level, and also at the next-to-leading order level in the small λn expansion near the multi-particle mass threshold. We apply this singular solutions formalism in the regime of ultra-high multiplicities where λn ≫ 1, and compute the leading positive ˜ n √{λ n} contribution to the exponent of the multi-particle rate in this large λn limit. The computation is carried out near the multi-particle mass threshold where the multiplicity n approaches its maximal value allowed by kinematics. This calculation relies on the idea of Gorsky and Voloshin to use a thin wall approximation for the singular solutions that resemble critical bubbles. This approximation is justified in precisely the high-multiplicity √{λ n}\\to ∞ regime of interest. Based on our results we show that the scalar theory with a spontaneous symmetry breaking used here as a simplified model for the Higgs sector, is very likely to realise the high-energy Higgsplosion phenomenon.

  3. Engineering robust intelligent robots

    NASA Astrophysics Data System (ADS)

    Hall, E. L.; Ali, S. M. Alhaj; Ghaffari, M.; Liao, X.; Cao, M.

    2010-01-01

    The purpose of this paper is to discuss the challenge of engineering robust intelligent robots. Robust intelligent robots may be considered as ones that not only work in one environment but rather in all types of situations and conditions. Our past work has described sensors for intelligent robots that permit adaptation to changes in the environment. We have also described the combination of these sensors with a "creative controller" that permits adaptive critic, neural network learning, and a dynamic database that permits task selection and criteria adjustment. However, the emphasis of this paper is on engineering solutions which are designed for robust operations and worst case situations such as day night cameras or rain and snow solutions. This ideal model may be compared to various approaches that have been implemented on "production vehicles and equipment" using Ethernet, CAN Bus and JAUS architectures and to modern, embedded, mobile computing architectures. Many prototype intelligent robots have been developed and demonstrated in terms of scientific feasibility but few have reached the stage of a robust engineering solution. Continual innovation and improvement are still required. The significance of this comparison is that it provides some insights that may be useful in designing future robots for various manufacturing, medical, and defense applications where robust and reliable performance is essential.

  4. Robust computational vision

    NASA Astrophysics Data System (ADS)

    Schunck, Brian G.

    1993-08-01

    This paper presents a paradigm for formulating reliable machine vision algorithms using methods from robust statistics. Machine vision is the process of estimating features from images by fitting a model to visual data. Vision research has produced an understanding of the physics and mathematics of visual processes. The fact that computer graphics programs can produce realistic renderings of artificial scenes indicates that our understanding of vision processes must be quite good. The premise of this paper is that the problem in applying computer vision in realistic scenes is not the fault of the theory of vision. We have good models for visual phenomena, but can do a better job of applying the models to images. Our understanding of vision must be used in computations that are robust to the kinds of errors that occur in visual signals. This paper argues that vision algorithms should be formulated using methods from robust regression. The nature of errors in visual signals is discussed, and a prescription for formulating robust algorithms is described. To illustrate the concepts, robust methods have been applied to several problems: surface reconstruction, dynamic stereo, image flow estimation, and edge detection.

  5. Robust distribution network reconfiguration

    SciTech Connect

    Lee, Changhyeok; Liu, Cong; Mehrotra, Sanjay; Bie, Zhaohong

    2015-03-01

    We propose a two-stage robust optimization model for the distribution network reconfiguration problem with load uncertainty. The first-stage decision is to configure the radial distribution network and the second-stage decision is to find the optimal a/c power flow of the reconfigured network for given demand realization. We solve the two-stage robust model by using a column-and-constraint generation algorithm, where the master problem and subproblem are formulated as mixed-integer second-order cone programs. Computational results for 16, 33, 70, and 94-bus test cases are reported. We find that the configuration from the robust model does not compromise much the power loss under the nominal load scenario compared to the configuration from the deterministic model, yet it provides the reliability of the distribution system for all scenarios in the uncertainty set.

  6. Systems approach to developmental biology--designs for robust patterning.

    PubMed

    Morishita, Yoshihiro; Hironaka, Ken-Ichi

    2013-04-01

    Patterning is an important step in animal development that generates spatially non-uniform gene expression patterns or spatially heterogeneous cellular responses. Patterning is realised by the generation and reading of positional information provided by spatial gradients of morphogens, diffusive chemicals in the extracellular environment. To achieve normal development, accurate patterning that is robust against noise is necessary. Here the authors describe how morphogen gradient formation and gradient interpretation processes are designed to achieve highly reproducible patterning. Furthermore, recent advancements in measurement and imaging techniques have enabled researchers to obtain quantitative dynamic and multi-physical data, not only for chemical events, but also for the geometrical and mechanical properties of cells in vivo. The authors briefly review some recent studies on the effects of such non-chemical events on patterning.

  7. Robustness of spatial micronetworks.

    PubMed

    McAndrew, Thomas C; Danforth, Christopher M; Bagrow, James P

    2015-04-01

    Power lines, roadways, pipelines, and other physical infrastructure are critical to modern society. These structures may be viewed as spatial networks where geographic distances play a role in the functionality and construction cost of links. Traditionally, studies of network robustness have primarily considered the connectedness of large, random networks. Yet for spatial infrastructure, physical distances must also play a role in network robustness. Understanding the robustness of small spatial networks is particularly important with the increasing interest in microgrids, i.e., small-area distributed power grids that are well suited to using renewable energy resources. We study the random failures of links in small networks where functionality depends on both spatial distance and topological connectedness. By introducing a percolation model where the failure of each link is proportional to its spatial length, we find that when failures depend on spatial distances, networks are more fragile than expected. Accounting for spatial effects in both construction and robustness is important for designing efficient microgrids and other network infrastructure.

  8. Wetting: Intrinsically robust hydrophobicity

    NASA Astrophysics Data System (ADS)

    Tian, Ye; Jiang, Lei

    2013-04-01

    Ceramic surfaces can be rendered hydrophobic by using polymeric modifiers, but these are not robust to harsh environments. A known family of rare-earth oxide ceramics is now found to exhibit intrinsic hydrophobicity, even after exposure to high temperatures and abrasive wear.

  9. Robustness of Embryonic Patterning

    NASA Astrophysics Data System (ADS)

    Barkai, Naama

    2002-03-01

    Developmental patterning proceeds reliably despite natural fluctuations in the expression levels of genes and changes in gene dosage. Patterning mechanisms that rely on morphogen gradients generally involve a network of feedback loops, which buffer against such perturbations. Although most components of the patterning networks have been identified and characterized, quantitative and mechanistic understanding of how their functions are integrated to achieve robustness is still missing. Here, we report a quantitative study of a morphogen gradient, determining cell fates in the fruit-fly embryo. We find that differential protein cleavage, coupled with selective diffusion, defines a robust system which can adjust to large variations in levels of the different protein components. The mechanism underlying robustness relies on the convergence of the signaling profile to a finite distribution, which in most regions is independent of physical boundary conditions such as production rates. An excess of signaling molecules is stored in a restricted spatial domain. This limiting profile property is exhibited by a class of reaction-diffusion equations, and may represent a general mechanism for achieving robustness in morphogen gradient systems. Experimental verification of model's predictions will be described.

  10. Robustness of spatial micronetworks

    NASA Astrophysics Data System (ADS)

    McAndrew, Thomas C.; Danforth, Christopher M.; Bagrow, James P.

    2015-04-01

    Power lines, roadways, pipelines, and other physical infrastructure are critical to modern society. These structures may be viewed as spatial networks where geographic distances play a role in the functionality and construction cost of links. Traditionally, studies of network robustness have primarily considered the connectedness of large, random networks. Yet for spatial infrastructure, physical distances must also play a role in network robustness. Understanding the robustness of small spatial networks is particularly important with the increasing interest in microgrids, i.e., small-area distributed power grids that are well suited to using renewable energy resources. We study the random failures of links in small networks where functionality depends on both spatial distance and topological connectedness. By introducing a percolation model where the failure of each link is proportional to its spatial length, we find that when failures depend on spatial distances, networks are more fragile than expected. Accounting for spatial effects in both construction and robustness is important for designing efficient microgrids and other network infrastructure.

  11. Robust adaptive self-structuring fuzzy control design for nonaffine, nonlinear systems

    NASA Astrophysics Data System (ADS)

    Chen, Pin-Cheng; Wang, Chi-Hsu; Lee, Tsu-Tian

    2011-01-01

    In this article, a robust adaptive self-structuring fuzzy control (RASFC) scheme for the uncertain or ill-defined nonlinear, nonaffine systems is proposed. The RASFC scheme is composed of a robust adaptive controller and a self-structuring fuzzy controller. In the self-structuring fuzzy controller design, a novel self-structuring fuzzy system (SFS) is used to approximate the unknown plant nonlinearity, and the SFS can automatically grow and prune fuzzy rules to realise a compact fuzzy rule base. The robust adaptive controller is designed to achieve an L 2 tracking performance to stabilise the closed-loop system. This L 2 tracking performance can provide a clear expression of tracking error in terms of the sum of lumped uncertainty and external disturbance, which has not been shown in previous works. Finally, five examples are presented to show that the proposed RASFC scheme can achieve favourable tracking performance, yet heavy computational burden is relieved.

  12. Operator-based robust nonlinear control system design for MIMO nonlinear plants with unknown coupling effects

    NASA Astrophysics Data System (ADS)

    Deng, Mingcong; Bi, Shuhui

    2010-09-01

    In this article, operator-based robust nonlinear control system design for multi-input multi-output (MIMO) plants with unknown coupling effects is considered. That is, by using operator-based robust nonlinear control design, coupling effects existing in the MIMO nonlinear plants can be decoupled based on a feedback design and robust right coprime factorisation approach, the coupling effects caused by controllers and plant outputs can be stabilised by using definition of Lipschitz operator and contraction mapping theorem, and output tracking performance can be realised by a tracking design scheme. Finally, a simulation example about temperature control process of 3-input/3-output aluminum plate is given to support the theoretical analysis.

  13. Comparing dependent robust correlations.

    PubMed

    Wilcox, Rand R

    2016-11-01

    Let r1 and r2 be two dependent estimates of Pearson's correlation. There is a substantial literature on testing H0  : ρ1  = ρ2 , the hypothesis that the population correlation coefficients are equal. However, it is well known that Pearson's correlation is not robust. Even a single outlier can have a substantial impact on Pearson's correlation, resulting in a misleading understanding about the strength of the association among the bulk of the points. A way of mitigating this concern is to use a correlation coefficient that guards against outliers, many of which have been proposed. But apparently there are no results on how to compare dependent robust correlation coefficients when there is heteroscedasicity. Extant results suggest that a basic percentile bootstrap will perform reasonably well. This paper reports simulation results indicating the extent to which this is true when using Spearman's rho, a Winsorized correlation or a skipped correlation.

  14. Doubly robust survival trees.

    PubMed

    Steingrimsson, Jon Arni; Diao, Liqun; Molinaro, Annette M; Strawderman, Robert L

    2016-09-10

    Estimating a patient's mortality risk is important in making treatment decisions. Survival trees are a useful tool and employ recursive partitioning to separate patients into different risk groups. Existing 'loss based' recursive partitioning procedures that would be used in the absence of censoring have previously been extended to the setting of right censored outcomes using inverse probability censoring weighted estimators of loss functions. In this paper, we propose new 'doubly robust' extensions of these loss estimators motivated by semiparametric efficiency theory for missing data that better utilize available data. Simulations and a data analysis demonstrate strong performance of the doubly robust survival trees compared with previously used methods. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  15. Robust verification analysis

    SciTech Connect

    Rider, William; Witkowski, Walt; Kamm, James R.; Wildey, Tim

    2016-02-15

    We introduce a new methodology for inferring the accuracy of computational simulations through the practice of solution verification. We demonstrate this methodology on examples from computational heat transfer, fluid dynamics and radiation transport. Our methodology is suited to both well- and ill-behaved sequences of simulations. Our approach to the analysis of these sequences of simulations incorporates expert judgment into the process directly via a flexible optimization framework, and the application of robust statistics. The expert judgment is systematically applied as constraints to the analysis, and together with the robust statistics guards against over-emphasis on anomalous analysis results. We have named our methodology Robust Verification. Our methodology is based on utilizing multiple constrained optimization problems to solve the verification model in a manner that varies the analysis' underlying assumptions. Constraints applied in the analysis can include expert judgment regarding convergence rates (bounds and expectations) as well as bounding values for physical quantities (e.g., positivity of energy or density). This approach then produces a number of error models, which are then analyzed through robust statistical techniques (median instead of mean statistics). This provides self-contained, data and expert informed error estimation including uncertainties for both the solution itself and order of convergence. Our method produces high quality results for the well-behaved cases relatively consistent with existing practice. The methodology can also produce reliable results for ill-behaved circumstances predicated on appropriate expert judgment. We demonstrate the method and compare the results with standard approaches used for both code and solution verification on well-behaved and ill-behaved simulations.

  16. Robust verification analysis

    NASA Astrophysics Data System (ADS)

    Rider, William; Witkowski, Walt; Kamm, James R.; Wildey, Tim

    2016-02-01

    We introduce a new methodology for inferring the accuracy of computational simulations through the practice of solution verification. We demonstrate this methodology on examples from computational heat transfer, fluid dynamics and radiation transport. Our methodology is suited to both well- and ill-behaved sequences of simulations. Our approach to the analysis of these sequences of simulations incorporates expert judgment into the process directly via a flexible optimization framework, and the application of robust statistics. The expert judgment is systematically applied as constraints to the analysis, and together with the robust statistics guards against over-emphasis on anomalous analysis results. We have named our methodology Robust Verification. Our methodology is based on utilizing multiple constrained optimization problems to solve the verification model in a manner that varies the analysis' underlying assumptions. Constraints applied in the analysis can include expert judgment regarding convergence rates (bounds and expectations) as well as bounding values for physical quantities (e.g., positivity of energy or density). This approach then produces a number of error models, which are then analyzed through robust statistical techniques (median instead of mean statistics). This provides self-contained, data and expert informed error estimation including uncertainties for both the solution itself and order of convergence. Our method produces high quality results for the well-behaved cases relatively consistent with existing practice. The methodology can also produce reliable results for ill-behaved circumstances predicated on appropriate expert judgment. We demonstrate the method and compare the results with standard approaches used for both code and solution verification on well-behaved and ill-behaved simulations.

  17. Robustness of Interdependent Networks

    NASA Astrophysics Data System (ADS)

    Havlin, Shlomo

    2011-03-01

    In interdependent networks, when nodes in one network fail, they cause dependent nodes in other networks to also fail. This may happen recursively and can lead to a cascade of failures. In fact, a failure of a very small fraction of nodes in one network may lead to the complete fragmentation of a system of many interdependent networks. We will present a framework for understanding the robustness of interacting networks subject to such cascading failures and provide a basic analytic approach that may be useful in future studies. We present exact analytical solutions for the critical fraction of nodes that upon removal will lead to a failure cascade and to a complete fragmentation of two interdependent networks in a first order transition. Surprisingly, analyzing complex systems as a set of interdependent networks may alter a basic assumption that network theory has relied on: while for a single network a broader degree distribution of the network nodes results in the network being more robust to random failures, for interdependent networks, the broader the distribution is, the more vulnerable the networks become to random failure. We also show that reducing the coupling between the networks leads to a change from a first order percolation phase transition to a second order percolation transition at a critical point. These findings pose a significant challenge to the future design of robust networks that need to consider the unique properties of interdependent networks.

  18. Robust impedance shaping telemanipulation

    SciTech Connect

    Colgate, J.E.

    1993-08-01

    When a human operator performs a task via a bilateral manipulator, the feel of the task is embodied in the mechanical impedance of the manipulator. Traditionally, a bilateral manipulator is designed for transparency; i.e., so that the impedance reflected through the manipulator closely approximates that of the task. Impedance shaping bilateral control, introduced here, differs in that it treats the bilateral manipulator as a means of constructively altering the impedance of a task. This concept is particularly valuable if the characteristic dimensions (e.g., force, length, time) of the task impedance are very different from those of the human limb. It is shown that a general form of impedance shaping control consists of a conventional power-scaling bilateral controller augmented with a real-time interactive task simulation (i.e., a virtual environment). An approach to impedance shaping based on kinematic similarity between tasks of different scale is introduced and illustrated with an example. It is shown that an important consideration in impedance shaping controller design is robustness; i.e., guaranteeing the stability of the operator/manipulator/task system. A general condition for the robustness of a bilateral manipulator is derived. This condition is based on the structured singular value ({mu}). An example of robust impedance shaping bilateral control is presented and discussed.

  19. Robustness of metabolic networks

    NASA Astrophysics Data System (ADS)

    Jeong, Hawoong

    2009-03-01

    We investigated the robustness of cellular metabolism by simulating the system-level computational models, and also performed the corresponding experiments to validate our predictions. We address the cellular robustness from the ``metabolite''-framework by using the novel concept of ``flux-sum,'' which is the sum of all incoming or outgoing fluxes (they are the same under the pseudo-steady state assumption). By estimating the changes of the flux-sum under various genetic and environmental perturbations, we were able to clearly decipher the metabolic robustness; the flux-sum around an essential metabolite does not change much under various perturbations. We also identified the list of the metabolites essential to cell survival, and then ``acclimator'' metabolites that can control the cell growth were discovered. Furthermore, this concept of ``metabolite essentiality'' should be useful in developing new metabolic engineering strategies for improved production of various bioproducts and designing new drugs that can fight against multi-antibiotic resistant superbacteria by knocking-down the enzyme activities around an essential metabolite. Finally, we combined a regulatory network with the metabolic network to investigate its effect on dynamic properties of cellular metabolism.

  20. Robustness in bacterial chemotaxis

    NASA Astrophysics Data System (ADS)

    Alon, U.; Surette, M. G.; Barkai, N.; Leibler, S.

    1999-01-01

    Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in theirbiochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme concentrations need to be adjusted in a precise manner, and any deviation from these `fine-tuned' values ruins the network's performance. An alternative possibility is that key properties of biochemical networks are robust; that is, they are insensitive to the precise values of the biochemical parameters. Here we address this issue in experiments using chemotaxis of Escherichia coli, one of the best-characterized sensory systems,. We focus on how response and adaptation to attractant signals vary with systematic changes in the intracellular concentration of the components of the chemotaxis network. We find that some properties, such as steady-state behaviour and adaptation time, show strong variations in response to varying protein concentrations. In contrast, the precision of adaptation is robust and does not vary with the protein concentrations. This is consistent with a recently proposed molecular mechanism for exact adaptation, where robustness is a direct consequence of the network's architecture.

  1. The Problem of Size in Robust Design

    NASA Technical Reports Server (NTRS)

    Koch, Patrick N.; Allen, Janet K.; Mistree, Farrokh; Mavris, Dimitri

    1997-01-01

    To facilitate the effective solution of multidisciplinary, multiobjective complex design problems, a departure from the traditional parametric design analysis and single objective optimization approaches is necessary in the preliminary stages of design. A necessary tradeoff becomes one of efficiency vs. accuracy as approximate models are sought to allow fast analysis and effective exploration of a preliminary design space. In this paper we apply a general robust design approach for efficient and comprehensive preliminary design to a large complex system: a high speed civil transport (HSCT) aircraft. Specifically, we investigate the HSCT wing configuration design, incorporating life cycle economic uncertainties to identify economically robust solutions. The approach is built on the foundation of statistical experimentation and modeling techniques and robust design principles, and is specialized through incorporation of the compromise Decision Support Problem for multiobjective design. For large problems however, as in the HSCT example, this robust design approach developed for efficient and comprehensive design breaks down with the problem of size - combinatorial explosion in experimentation and model building with number of variables -and both efficiency and accuracy are sacrificed. Our focus in this paper is on identifying and discussing the implications and open issues associated with the problem of size for the preliminary design of large complex systems.

  2. TLE uncertainty estimation using robust weighted differencing

    NASA Astrophysics Data System (ADS)

    Geul, Jacco; Mooij, Erwin; Noomen, Ron

    2017-05-01

    Accurate knowledge of satellite orbit errors is essential for many types of analyses. Unfortunately, for two-line elements (TLEs) this is not available. This paper presents a weighted differencing method using robust least-squares regression for estimating many important error characteristics. The method is applied to both classic and enhanced TLEs, compared to previous implementations, and validated using Global Positioning System (GPS) solutions for the GOCE satellite in Low-Earth Orbit (LEO), prior to its re-entry. The method is found to be more accurate than previous TLE differencing efforts in estimating initial uncertainty, as well as error growth. The method also proves more reliable and requires no data filtering (such as outlier removal). Sensitivity analysis shows a strong relationship between argument of latitude and covariance (standard deviations and correlations), which the method is able to approximate. Overall, the method proves accurate, computationally fast, and robust, and is applicable to any object in the satellite catalogue (SATCAT).

  3. New analytical input impedance calculation for fast design of printed narrow slot antenna

    NASA Astrophysics Data System (ADS)

    Akan, Volkan; Yazgan, Erdem

    2011-09-01

    In this article, fast and simple closed-form relations are presented to calculate input impedance of filamentary-excited printed narrow slot antenna on electrically thin dielectric substrate near to half wavelength resonance frequency. This antenna is a complementary structure of thin printed dipole antenna. The obtained formulations have been verified numerically by a commercially available full-wave electromagnetic simulator and then a prototype antenna has been produced. Experimental measurements are realised on the antenna and these measurement values of input impedance also have verified analytical relations and numerical simulations. It is shown that analytical, numerical and experimental results are close to each other. Therefore, these relations can be utilised as an initial design step just before making detailed numerical analyses. Besides, the given relations can be easily realised in CAD-oriented platforms for fast calculations.

  4. A new high-performance CMOS fully differential second-generation current conveyor with application example of biquad filter realisation

    NASA Astrophysics Data System (ADS)

    Kaçar, Fırat; Metin, Bilgin; Kuntman, Hakan; Cicekoglu, Oguzhan

    2010-05-01

    In this article, a new complementary metal oxide semiconductor (CMOS) high-performance fully differential second-generation current conveyor (FDCCII) implementation is proposed. The presented FDCCII provides high-output impedance at terminals Z+ and Z-, good linearity and excellent output-input current gain accuracy. Also, the proposed FDCCII circuit operates at a supply voltage of ±1.3 V. The applications of the FDCCII to realise voltage-mode multifunction filters are given. Simulations are performed using TSMC CMOS 0.35-μm technology to verify theoretical results.

  5. Robust Photon Locking

    SciTech Connect

    Bayer, T.; Wollenhaupt, M.; Sarpe-Tudoran, C.; Baumert, T.

    2009-01-16

    We experimentally demonstrate a strong-field coherent control mechanism that combines the advantages of photon locking (PL) and rapid adiabatic passage (RAP). Unlike earlier implementations of PL and RAP by pulse sequences or chirped pulses, we use shaped pulses generated by phase modulation of the spectrum of a femtosecond laser pulse with a generalized phase discontinuity. The novel control scenario is characterized by a high degree of robustness achieved via adiabatic preparation of a state of maximum coherence. Subsequent phase control allows for efficient switching among different target states. We investigate both properties by photoelectron spectroscopy on potassium atoms interacting with the intense shaped light field.

  6. Complexity and robustness

    PubMed Central

    Carlson, J. M.; Doyle, John

    2002-01-01

    Highly optimized tolerance (HOT) was recently introduced as a conceptual framework to study fundamental aspects of complexity. HOT is motivated primarily by systems from biology and engineering and emphasizes, (i) highly structured, nongeneric, self-dissimilar internal configurations, and (ii) robust yet fragile external behavior. HOT claims these are the most important features of complexity and not accidents of evolution or artifices of engineering design but are inevitably intertwined and mutually reinforcing. In the spirit of this collection, our paper contrasts HOT with alternative perspectives on complexity, drawing on real-world examples and also model systems, particularly those from self-organized criticality. PMID:11875207

  7. Robust Kriged Kalman Filtering

    SciTech Connect

    Baingana, Brian; Dall'Anese, Emiliano; Mateos, Gonzalo; Giannakis, Georgios B.

    2015-11-11

    Although the kriged Kalman filter (KKF) has well-documented merits for prediction of spatial-temporal processes, its performance degrades in the presence of outliers due to anomalous events, or measurement equipment failures. This paper proposes a robust KKF model that explicitly accounts for presence of measurement outliers. Exploiting outlier sparsity, a novel l1-regularized estimator that jointly predicts the spatial-temporal process at unmonitored locations, while identifying measurement outliers is put forth. Numerical tests are conducted on a synthetic Internet protocol (IP) network, and real transformer load data. Test results corroborate the effectiveness of the novel estimator in joint spatial prediction and outlier identification.

  8. Robust Systems Test Framework

    SciTech Connect

    Ballance, Robert A.

    2003-01-01

    The Robust Systems Test Framework (RSTF) provides a means of specifying and running test programs on various computation platforms. RSTF provides a level of specification above standard scripting languages. During a set of runs, standard timing information is collected. The RSTF specification can also gather job-specific information, and can include ways to classify test outcomes. All results and scripts can be stored into and retrieved from an SQL database for later data analysis. RSTF also provides operations for managing the script and result files, and for compiling applications and gathering compilation information such as optimization flags.

  9. Robustness of Cantor diffractals.

    PubMed

    Verma, Rupesh; Sharma, Manoj Kumar; Banerjee, Varsha; Senthilkumaran, Paramasivam

    2013-04-08

    Diffractals are electromagnetic waves diffracted by a fractal aperture. In an earlier paper, we reported an important property of Cantor diffractals, that of redundancy [R. Verma et. al., Opt. Express 20, 8250 (2012)]. In this paper, we report another important property, that of robustness. The question we address is: How much disorder in the Cantor grating can be accommodated by diffractals to continue to yield faithfully its fractal dimension and generator? This answer is of consequence in a number of physical problems involving fractal architecture.

  10. Robust control for uncertain structures

    NASA Technical Reports Server (NTRS)

    Douglas, Joel; Athans, Michael

    1991-01-01

    Viewgraphs on robust control for uncertain structures are presented. Topics covered include: robust linear quadratic regulator (RLQR) formulas; mismatched LQR design; RLQR design; interpretations of RLQR design; disturbance rejection; and performance comparisons: RLQR vs. mismatched LQR.

  11. Robust reflective pupil slicing technology

    NASA Astrophysics Data System (ADS)

    Meade, Jeffrey T.; Behr, Bradford B.; Cenko, Andrew T.; Hajian, Arsen R.

    2014-07-01

    Tornado Spectral Systems (TSS) has developed the High Throughput Virtual Slit (HTVSTM), robust all-reflective pupil slicing technology capable of replacing the slit in research-, commercial- and MIL-SPEC-grade spectrometer systems. In the simplest configuration, the HTVS allows optical designers to remove the lossy slit from pointsource spectrometers and widen the input slit of long-slit spectrometers, greatly increasing throughput without loss of spectral resolution or cross-dispersion information. The HTVS works by transferring etendue between image plane axes but operating in the pupil domain rather than at a focal plane. While useful for other technologies, this is especially relevant for spectroscopic applications by performing the same spectral narrowing as a slit without throwing away light on the slit aperture. HTVS can be implemented in all-reflective designs and only requires a small number of reflections for significant spectral resolution enhancement-HTVS systems can be efficiently implemented in most wavelength regions. The etendueshifting operation also provides smooth scaling with input spot/image size without requiring reconfiguration for different targets (such as different seeing disk diameters or different fiber core sizes). Like most slicing technologies, HTVS provides throughput increases of several times without resolution loss over equivalent slitbased designs. HTVS technology enables robust slit replacement in point-source spectrometer systems. By virtue of pupilspace operation this technology has several advantages over comparable image-space slicer technology, including the ability to adapt gracefully and linearly to changing source size and better vertical packing of the flux distribution. Additionally, this technology can be implemented with large slicing factors in both fast and slow beams and can easily scale from large, room-sized spectrometers through to small, telescope-mounted devices. Finally, this same technology is directly

  12. ADAPTIVE ROBUST VARIABLE SELECTION

    PubMed Central

    Fan, Jianqing; Fan, Yingying; Barut, Emre

    2014-01-01

    Heavy-tailed high-dimensional data are commonly encountered in various scientific fields and pose great challenges to modern statistical analysis. A natural procedure to address this problem is to use penalized quantile regression with weighted L1-penalty, called weighted robust Lasso (WR-Lasso), in which weights are introduced to ameliorate the bias problem induced by the L1-penalty. In the ultra-high dimensional setting, where the dimensionality can grow exponentially with the sample size, we investigate the model selection oracle property and establish the asymptotic normality of the WR-Lasso. We show that only mild conditions on the model error distribution are needed. Our theoretical results also reveal that adaptive choice of the weight vector is essential for the WR-Lasso to enjoy these nice asymptotic properties. To make the WR-Lasso practically feasible, we propose a two-step procedure, called adaptive robust Lasso (AR-Lasso), in which the weight vector in the second step is constructed based on the L1-penalized quantile regression estimate from the first step. This two-step procedure is justified theoretically to possess the oracle property and the asymptotic normality. Numerical studies demonstrate the favorable finite-sample performance of the AR-Lasso. PMID:25580039

  13. Robust omniphobic surfaces

    PubMed Central

    Tuteja, Anish; Choi, Wonjae; Mabry, Joseph M.; McKinley, Gareth H.; Cohen, Robert E.

    2008-01-01

    Superhydrophobic surfaces display water contact angles greater than 150° in conjunction with low contact angle hysteresis. Microscopic pockets of air trapped beneath the water droplets placed on these surfaces lead to a composite solid-liquid-air interface in thermodynamic equilibrium. Previous experimental and theoretical studies suggest that it may not be possible to form similar fully-equilibrated, composite interfaces with drops of liquids, such as alkanes or alcohols, that possess significantly lower surface tension than water (γlv = 72.1 mN/m). In this work we develop surfaces possessing re-entrant texture that can support strongly metastable composite solid-liquid-air interfaces, even with very low surface tension liquids such as pentane (γlv = 15.7 mN/m). Furthermore, we propose four design parameters that predict the measured contact angles for a liquid droplet on a textured surface, as well as the robustness of the composite interface, based on the properties of the solid surface and the contacting liquid. These design parameters allow us to produce two different families of re-entrant surfaces— randomly-deposited electrospun fiber mats and precisely fabricated microhoodoo surfaces—that can each support a robust composite interface with essentially any liquid. These omniphobic surfaces display contact angles greater than 150° and low contact angle hysteresis with both polar and nonpolar liquids possessing a wide range of surface tensions. PMID:19001270

  14. Mommy is only happy! Dutch mothers' realisation of speech sounds in infant-directed speech expresses emotion, not didactic intent.

    PubMed

    Benders, Titia

    2013-12-01

    Exaggeration of the vowel space in infant-directed speech (IDS) is well documented for English, but not consistently replicated in other languages or for other speech-sound contrasts. A second attested, but less discussed, pattern of change in IDS is an overall rise of the formant frequencies, which may reflect an affective speaking style. The present study investigates longitudinally how Dutch mothers change their corner vowels, voiceless fricatives, and pitch when speaking to their infant at 11 and 15 months of age. In comparison to adult-directed speech (ADS), Dutch IDS has a smaller vowel space, higher second and third formant frequencies in the vowels, and a higher spectral frequency in the fricatives. The formants of the vowels and spectral frequency of the fricatives are raised more strongly for infants at 11 than at 15 months, while the pitch is more extreme in IDS to 15-month olds. These results show that enhanced positive affect is the main factor influencing Dutch mothers' realisation of speech sounds in IDS, especially to younger infants. This study provides evidence that mothers' expression of emotion in IDS can influence the realisation of speech sounds, and that the loss or gain of speech clarity may be secondary effects of affect. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. A framework for the systematic realisation of phenomena for enhanced sensing of radiological and nuclear materials, and radiation.

    PubMed

    Healy, M J F

    2015-09-01

    The quest for new sensing phenomena continues because detecting, discriminating, identifying, measuring and monitoring nuclear materials and their radiation from greater range, at lower concentrations, and in a more timely fashion brings greater safety, security and efficiency. The potential phenomena are diverse, and those that have been realised can be found in disparate fields of science, engineering and medicine, which makes the full range difficult to realise and record. The framework presented here offers a means to systematically and comprehensively explore nuclear sensing phenomena. The approach is based on the fundamental concepts of matter and energy, where the sequence starts with the original nuclear material and its emissions, and progressively considers signatures arising from secondary effects and the emissions from associated materials and the environment. Concepts of operations such as active and passive interrogation, and networked sensing are considered. In this operational light, unpacking nuclear signatures forces a fresh look at the sensing concept. It also exposes how some phenomena that exist in established technology may be considered novel based on how they could be exploited rather than what they fundamentally are. This article selects phenomena purely to illustrate the framework and how it can be best used to foster creativity in the quest for novel phenomena rather than exhaustively listing, categorising or comparing any practical aspects of candidate phenomena.

  16. The Rotated Speeded-Up Robust Features Algorithm (R-SURF)

    DTIC Science & Technology

    2014-06-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited THE ROTATED SPEEDED ......ABSTRACT (maximum 200 words) Weaknesses in the Fast Hessian detector utilized by the speeded -up robust features (SURF) algorithm are examined in

  17. Evolving Robust Gene Regulatory Networks

    PubMed Central

    Noman, Nasimul; Monjo, Taku; Moscato, Pablo; Iba, Hitoshi

    2015-01-01

    Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of ‘parts’ and ‘devices’. The robustness of gene regulatory networks (GRNs) is ascribed chiefly to the underlying topology. The automatic designing capability of GRN topology that can exhibit robust behavior can dramatically change the current practice in synthetic biology. A recent study shows that Darwinian evolution can gradually develop higher topological robustness. Subsequently, this work presents an evolutionary algorithm that simulates natural evolution in silico, for identifying network topologies that are robust to perturbations. We present a Monte Carlo based method for quantifying topological robustness and designed a fitness approximation approach for efficient calculation of topological robustness which is computationally very intensive. The proposed framework was verified using two classic GRN behaviors: oscillation and bistability, although the framework is generalized for evolving other types of responses. The algorithm identified robust GRN architectures which were verified using different analysis and comparison. Analysis of the results also shed light on the relationship among robustness, cooperativity and complexity. This study also shows that nature has already evolved very robust architectures for its crucial systems; hence simulation of this natural process can be very valuable for designing robust biological systems. PMID:25616055

  18. Robustness in Digital Hardware

    NASA Astrophysics Data System (ADS)

    Woods, Roger; Lightbody, Gaye

    The growth in electronics has probably been the equivalent of the Industrial Revolution in the past century in terms of how much it has transformed our daily lives. There is a great dependency on technology whether it is in the devices that control travel (e.g., in aircraft or cars), our entertainment and communication systems, or our interaction with money, which has been empowered by the onset of Internet shopping and banking. Despite this reliance, there is still a danger that at some stage devices will fail within the equipment's lifetime. The purpose of this chapter is to look at the factors causing failure and address possible measures to improve robustness in digital hardware technology and specifically chip technology, giving a long-term forecast that will not reassure the reader!

  19. Robust snapshot interferometric spectropolarimetry.

    PubMed

    Kim, Daesuk; Seo, Yoonho; Yoon, Yonghee; Dembele, Vamara; Yoon, Jae Woong; Lee, Kyu Jin; Magnusson, Robert

    2016-05-15

    This Letter describes a Stokes vector measurement method based on a snapshot interferometric common-path spectropolarimeter. The proposed scheme, which employs an interferometric polarization-modulation module, can extract the spectral polarimetric parameters Ψ(k) and Δ(k) of a transmissive anisotropic object by which an accurate Stokes vector can be calculated in the spectral domain. It is inherently strongly robust to the object 3D pose variation, since it is designed distinctly so that the measured object can be placed outside of the interferometric module. Experiments are conducted to verify the feasibility of the proposed system. The proposed snapshot scheme enables us to extract the spectral Stokes vector of a transmissive anisotropic object within tens of msec with high accuracy.

  20. Robust automated knowledge capture.

    SciTech Connect

    Stevens-Adams, Susan Marie; Abbott, Robert G.; Forsythe, James Chris; Trumbo, Michael Christopher Stefan; Haass, Michael Joseph; Hendrickson, Stacey M. Langfitt

    2011-10-01

    This report summarizes research conducted through the Sandia National Laboratories Robust Automated Knowledge Capture Laboratory Directed Research and Development project. The objective of this project was to advance scientific understanding of the influence of individual cognitive attributes on decision making. The project has developed a quantitative model known as RumRunner that has proven effective in predicting the propensity of an individual to shift strategies on the basis of task and experience related parameters. Three separate studies are described which have validated the basic RumRunner model. This work provides a basis for better understanding human decision making in high consequent national security applications, and in particular, the individual characteristics that underlie adaptive thinking.

  1. Modeling robust QSAR.

    PubMed

    Polanski, Jaroslaw; Bak, Andrzej; Gieleciak, Rafal; Magdziarz, Tomasz

    2006-01-01

    Quantitative Structure Activity Relationship (QSAR) is a term describing a variety of approaches that are of substantial interest for chemistry. This method can be defined as indirect molecular design by the iterative sampling of the chemical compounds space to optimize a certain property and thus indirectly design the molecular structure having this property. However, modeling the interactions of chemical molecules in biological systems provides highly noisy data, which make predictions a roulette risk. In this paper we briefly review the origins for this noise, particularly in multidimensional QSAR. This was classified as the data, superimposition, molecular similarity, conformational, and molecular recognition noise. We also indicated possible robust answers that can improve modeling and predictive ability of QSAR, especially the self-organizing mapping of molecular objects, in particular, the molecular surfaces, a method that was brought into chemistry by Gasteiger and Zupan.

  2. Robust Rocket Engine Concept

    NASA Technical Reports Server (NTRS)

    Lorenzo, Carl F.

    1995-01-01

    The potential for a revolutionary step in the durability of reusable rocket engines is made possible by the combination of several emerging technologies. The recent creation and analytical demonstration of life extending (or damage mitigating) control technology enables rapid rocket engine transients with minimum fatigue and creep damage. This technology has been further enhanced by the formulation of very simple but conservative continuum damage models. These new ideas when combined with recent advances in multidisciplinary optimization provide the potential for a large (revolutionary) step in reusable rocket engine durability. This concept has been named the robust rocket engine concept (RREC) and is the basic contribution of this paper. The concept also includes consideration of design innovations to minimize critical point damage.

  3. Real Time & Power Efficient Adaptive - Robust Control

    NASA Astrophysics Data System (ADS)

    Ioan Gliga, Lavinius; Constantin Mihai, Cosmin; Lupu, Ciprian; Popescu, Dumitru

    2017-01-01

    A design procedure for a control system suited for dynamic variable processes is presented in this paper. The proposed adaptive - robust control strategy considers both adaptive control advantages and robust control benefits. It estimates the degradation of the system’s performances due to the dynamic variation in the process and it then utilizes it to determine when the system must be adapted with a redesign of the robust controller. A single integral criterion is used for the identification of the process, and for the design of the control algorithm, which is expressed in direct form, through a cost function defined in the space of the parameters of both the process and the controller. For the minimization of this nonlinear function, an adequate mathematical programming minimization method is used. The theoretical approach presented in this paper was validated for a closed loop control system, simulated in an application developed in C. Because of the reduced number of operations, this method is suitable for implementation on fast processes. Due to its effectiveness, it increases the idle time of the CPU, thereby saving electrical energy.

  4. A robust BAO extractor

    NASA Astrophysics Data System (ADS)

    Noda, Eugenio; Peloso, Marco; Pietroni, Massimo

    2017-08-01

    We define a procedure to extract the oscillating part of a given nonlinear Power Spectrum, and derive an equation describing its evolution including the leading effects at all scales. The intermediate scales are taken into account by standard perturbation theory, the long range (IR) displacements are included by using consistency relations, and the effect of small (UV) scales is included via effective coefficients computed in simulations. We show that the UV effects are irrelevant in the evolution of the oscillating part, while they play a crucial role in reproducing the smooth component. Our "extractor" operator can be applied to simulations and real data in order to extract the Baryonic Acoustic Oscillations (BAO) without any fitting function and nuisance parameter. We conclude that the nonlinear evolution of BAO can be accurately reproduced at all scales down to 0z= by our fast analytical method, without any need of extra parameters fitted from simulations.

  5. High-performance quantitative robust switching control for optical telescopes

    NASA Astrophysics Data System (ADS)

    Lounsbury, William P.; Garcia-Sanz, Mario

    2014-07-01

    This paper introduces an innovative robust and nonlinear control design methodology for high-performance servosystems in optical telescopes. The dynamics of optical telescopes typically vary according to azimuth and altitude angles, temperature, friction, speed and acceleration, leading to nonlinearities and plant parameter uncertainty. The methodology proposed in this paper combines robust Quantitative Feedback Theory (QFT) techniques with nonlinear switching strategies that achieve simultaneously the best characteristics of a set of very active (fast) robust QFT controllers and very stable (slow) robust QFT controllers. A general dynamic model and a variety of specifications from several different commercially available amateur Newtonian telescopes are used for the controller design as well as the simulation and validation. It is also proven that the nonlinear/switching controller is stable for any switching strategy and switching velocity, according to described frequency conditions based on common quadratic Lyapunov functions (CQLF) and the circle criterion.

  6. Critical Role of Diels-Adler Adducts to Realise Stretchable Transparent Electrodes Based on Silver Nanowires and Silicone Elastomer

    NASA Astrophysics Data System (ADS)

    Heo, Gaeun; Pyo, Kyoung-Hee; Lee, Da Hee; Kim, Youngmin; Kim, Jong-Woong

    2016-05-01

    This paper presents the successful fabrication of a transparent electrode comprising a sandwich structure of silicone/Ag nanowires (AgNWs)/silicone equipped with Diels-Alder (DA) adducts as crosslinkers to realise highly stable stretchability. Because of the reversible DA reaction, the crosslinked silicone successfully bonds with the silicone overcoat, which should completely seal the electrode. Thus, any surrounding liquid cannot leak through the interfaces among the constituents. Furthermore, the nanowires are protected by the silicone cover when they are stressed by mechanical loads such as bending, folding, and stretching. After delicate optimisation of the layered silicone/AgNW/silicone sandwich structure, a stretchable transparent electrode which can withstand 1000 cycles of 50% stretching-releasing with an exceptionally high stability and reversibility was fabricated. This structure can be used as a transparent strain sensor; it possesses a strong piezoresistivity with a gauge factor greater than 11.

  7. Realisation of magnetostructural coupling and a large magnetocaloric effect in the MnCoGe1+x system

    NASA Astrophysics Data System (ADS)

    Hassan, Najam ul; Chen, Fenghua; Zhang, Mingang; Shah, Ishfaq Ahmad; Liu, Jun; Gong, Yuanyuan; Xu, Guizhou; Xu, Feng

    2017-10-01

    Magnetic field-induced magnetostructural transformations taking place in MnCoGe-based alloys attract considerable attention due to their associated multi-magnetoresponsive effects. The key to maximising these effects across a wide working temperature range is to increase the magnetisation difference during the transformation and simultaneously sustain the Curie temperatures of the Ni2In and TiNiSi phases. In this work, we achieve the above goals by importing additional Ge atoms into the MnCoGe alloy, as the increase in Ge content sharply decreases the transformation temperature but does not influence the Curie temperatures in the system. As a result, magnetostructural transformation between paramagnetic Ni2In and ferromagnetic TiNiSi phases is realised within a Curie-temperature window of 70 K. The magnetostructural transformation can be induced by the magnetic field, bringing about considerable entropy change.

  8. Critical Role of Diels–Adler Adducts to Realise Stretchable Transparent Electrodes Based on Silver Nanowires and Silicone Elastomer

    PubMed Central

    Heo, Gaeun; Pyo, Kyoung-hee; Lee, Da Hee; Kim, Youngmin; Kim, Jong-Woong

    2016-01-01

    This paper presents the successful fabrication of a transparent electrode comprising a sandwich structure of silicone/Ag nanowires (AgNWs)/silicone equipped with Diels–Alder (DA) adducts as crosslinkers to realise highly stable stretchability. Because of the reversible DA reaction, the crosslinked silicone successfully bonds with the silicone overcoat, which should completely seal the electrode. Thus, any surrounding liquid cannot leak through the interfaces among the constituents. Furthermore, the nanowires are protected by the silicone cover when they are stressed by mechanical loads such as bending, folding, and stretching. After delicate optimisation of the layered silicone/AgNW/silicone sandwich structure, a stretchable transparent electrode which can withstand 1000 cycles of 50% stretching–releasing with an exceptionally high stability and reversibility was fabricated. This structure can be used as a transparent strain sensor; it possesses a strong piezoresistivity with a gauge factor greater than 11. PMID:27140436

  9. Robust Weak Measurements

    NASA Astrophysics Data System (ADS)

    Tollaksen, Jeff; Aharonov, Yakir

    2006-03-01

    We introduce a new type of weak measurement which yields a quantum average of weak values that is robust, outside the range of eigenvalues, extends the valid regime for weak measurements, and for which the probability of obtaining the pre- and post-selected ensemble is not exponentially rare. This result extends the applicability of weak values, shifts the statistical interpretation previously attributed to weak values and suggests that the weak value is a property of every pre- and post-selected ensemble. We then apply this new weak measurement to Hardy's paradox. Usually the paradox is dismissed on grounds of counterfactuality, i.e., because the paradoxical effects appear only when one considers results of experiments which do not actually take place. We suggest a new set of measurements in connection with Hardy's scheme, and show that when they are actually performed, they yield strange and surprising outcomes. More generally, we claim that counterfactual paradoxes point to a deeper structure inherent to quantum mechanics characterized by weak values (Aharonov Y, Botero A, Popescu S, Reznik B, Tollaksen J, Physics Letters A, 301 (3-4): 130-138, 2002).

  10. Robust relativistic bit commitment

    NASA Astrophysics Data System (ADS)

    Chakraborty, Kaushik; Chailloux, André; Leverrier, Anthony

    2016-12-01

    Relativistic cryptography exploits the fact that no information can travel faster than the speed of light in order to obtain security guarantees that cannot be achieved from the laws of quantum mechanics alone. Recently, Lunghi et al. [Phys. Rev. Lett. 115, 030502 (2015), 10.1103/PhysRevLett.115.030502] presented a bit-commitment scheme where each party uses two agents that exchange classical information in a synchronized fashion, and that is both hiding and binding. A caveat is that the commitment time is intrinsically limited by the spatial configuration of the players, and increasing this time requires the agents to exchange messages during the whole duration of the protocol. While such a solution remains computationally attractive, its practicality is severely limited in realistic settings since all communication must remain perfectly synchronized at all times. In this work, we introduce a robust protocol for relativistic bit commitment that tolerates failures of the classical communication network. This is done by adding a third agent to both parties. Our scheme provides a quadratic improvement in terms of expected sustain time compared with the original protocol, while retaining the same level of security.

  11. Robust cognitive change.

    PubMed

    Salthouse, Timothy A

    2012-07-01

    Two major challenges facing researchers interested in cognitive change are that measures of change are often not very reliable, and they may reflect effects of prior test experience in addition to the factors of primary interest. One approach to dealing with these problems is to obtain multiple measures of change on parallel versions of the same tests in a measurement burst design. A total of 783 adults performed three parallel versions of cognitive tests on two occasions separated by an average of 2.6 years. Performance increased substantially across the three sessions within each occasion, and for all but vocabulary ability these within-occasion improvements were considerably larger than the between-occasion changes. Reliabilities of the changes in composite scores were low, but averages of the three changes had larger, albeit still quite modest, reliabilities. In some cognitive abilities individual differences were evident in the relation of prior test experience and the magnitude of longitudinal change. Although multiple assessments are more time consuming than traditional measurement procedures, the resulting estimates of change are more robust than those from conventional methods, and also allow the influence of practice on change to be systematically investigated.

  12. Robust Nonlinear Neural Codes

    NASA Astrophysics Data System (ADS)

    Yang, Qianli; Pitkow, Xaq

    2015-03-01

    Most interesting natural sensory stimuli are encoded in the brain in a form that can only be decoded nonlinearly. But despite being a core function of the brain, nonlinear population codes are rarely studied and poorly understood. Interestingly, the few existing models of nonlinear codes are inconsistent with known architectural features of the brain. In particular, these codes have information content that scales with the size of the cortical population, even if that violates the data processing inequality by exceeding the amount of information entering the sensory system. Here we provide a valid theory of nonlinear population codes by generalizing recent work on information-limiting correlations in linear population codes. Although these generalized, nonlinear information-limiting correlations bound the performance of any decoder, they also make decoding more robust to suboptimal computation, allowing many suboptimal decoders to achieve nearly the same efficiency as an optimal decoder. Although these correlations are extremely difficult to measure directly, particularly for nonlinear codes, we provide a simple, practical test by which one can use choice-related activity in small populations of neurons to determine whether decoding is suboptimal or optimal and limited by correlated noise. We conclude by describing an example computation in the vestibular system where this theory applies. QY and XP was supported by a grant from the McNair foundation.

  13. Active robust control of wind turbines

    NASA Astrophysics Data System (ADS)

    Rezaei, Vahid

    The research work conducted in this thesis focuses on robustness of wind energy conversion system with respect to faults in pitch actuator in order to prevent unnecessary emergency shutdown, and keep the turbine operational without significant inefficiency in its overall performance. The objective is to investigate the feasibility of using a fault estimator and a light detection and ranging (LIDAR) system as additional sensors to design a suitable control system for wind turbines. Robust control technique is used to address these issues. Three controllers are proposed in this work that try to address sources of inaccuracy in wind turbine operation: An active fault tolerant controller is first designed using a fault estimator. It is shown that a set of locally robust controllers with respect to the fault, together with a suitable smooth mixing approach, manages to overcome the problem of faults in the pitch actuator. To address the wind-dependent behavior of turbines, a second controller is designed using the LIDAR sensor. In this configuration, LIDAR provides the look ahead wind information and generates a smooth scheduling signal to provide active robustness with respect to the changes in wind speed. Lastly, utilizing both the fault estimator and LIDAR, a 2-dimensional wind-dependent active fault tolerant controller is developed to control the wind turbine in region 3 of operation. The feasibility of the proposed ideas is verified in simulation. For this purpose, the US National Renewable Energy Laboratory's FAST code is used to model the 3-balded controls advanced research turbine. A discussion on practical considerations and ideas for future work are also presented.

  14. FAST: FAST Analysis of Sequences Toolbox

    PubMed Central

    Lawrence, Travis J.; Kauffman, Kyle T.; Amrine, Katherine C. H.; Carper, Dana L.; Lee, Raymond S.; Becich, Peter J.; Canales, Claudia J.; Ardell, David H.

    2015-01-01

    FAST (FAST Analysis of Sequences Toolbox) provides simple, powerful open source command-line tools to filter, transform, annotate and analyze biological sequence data. Modeled after the GNU (GNU's Not Unix) Textutils such as grep, cut, and tr, FAST tools such as fasgrep, fascut, and fastr make it easy to rapidly prototype expressive bioinformatic workflows in a compact and generic command vocabulary. Compact combinatorial encoding of data workflows with FAST commands can simplify the documentation and reproducibility of bioinformatic protocols, supporting better transparency in biological data science. Interface self-consistency and conformity with conventions of GNU, Matlab, Perl, BioPerl, R, and GenBank help make FAST easy and rewarding to learn. FAST automates numerical, taxonomic, and text-based sorting, selection and transformation of sequence records and alignment sites based on content, index ranges, descriptive tags, annotated features, and in-line calculated analytics, including composition and codon usage. Automated content- and feature-based extraction of sites and support for molecular population genetic statistics make FAST useful for molecular evolutionary analysis. FAST is portable, easy to install and secure thanks to the relative maturity of its Perl and BioPerl foundations, with stable releases posted to CPAN. Development as well as a publicly accessible Cookbook and Wiki are available on the FAST GitHub repository at https://github.com/tlawrence3/FAST. The default data exchange format in FAST is Multi-FastA (specifically, a restriction of BioPerl FastA format). Sanger and Illumina 1.8+ FastQ formatted files are also supported. FAST makes it easier for non-programmer biologists to interactively investigate and control biological data at the speed of thought. PMID:26042145

  15. Robustness surfaces of complex networks

    NASA Astrophysics Data System (ADS)

    Manzano, Marc; Sahneh, Faryad; Scoglio, Caterina; Calle, Eusebi; Marzo, Jose Luis

    2014-09-01

    Despite the robustness of complex networks has been extensively studied in the last decade, there still lacks a unifying framework able to embrace all the proposed metrics. In the literature there are two open issues related to this gap: (a) how to dimension several metrics to allow their summation and (b) how to weight each of the metrics. In this work we propose a solution for the two aforementioned problems by defining the R*-value and introducing the concept of robustness surface (Ω). The rationale of our proposal is to make use of Principal Component Analysis (PCA). We firstly adjust to 1 the initial robustness of a network. Secondly, we find the most informative robustness metric under a specific failure scenario. Then, we repeat the process for several percentage of failures and different realizations of the failure process. Lastly, we join these values to form the robustness surface, which allows the visual assessment of network robustness variability. Results show that a network presents different robustness surfaces (i.e., dissimilar shapes) depending on the failure scenario and the set of metrics. In addition, the robustness surface allows the robustness of different networks to be compared.

  16. Robust Control Feedback and Learning

    DTIC Science & Technology

    2002-11-30

    98-1-0026 5b. GRANT NUMBER Robust Control, Feedback and Learning F49620-98-1-0026 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Michael G...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 Final Report: ROBUST CONTROL FEEDBACK AND LEARNING AFOSR Grant F49620-98-1-0026 October 1...Philadelphia, PA, 2000. [16] M. G. Safonov. Recent advances in robust control, feedback and learning . In S. 0. R. Moheimani, editor, Perspectives in Robust

  17. Fast approximate stochastic tractography.

    PubMed

    Iglesias, Juan Eugenio; Thompson, Paul M; Liu, Cheng-Yi; Tu, Zhuowen

    2012-01-01

    Many different probabilistic tractography methods have been proposed in the literature to overcome the limitations of classical deterministic tractography: (i) lack of quantitative connectivity information; and (ii) robustness to noise, partial volume effects and selection of seed region. However, these methods rely on Monte Carlo sampling techniques that are computationally very demanding. This study presents an approximate stochastic tractography algorithm (FAST) that can be used interactively, as opposed to having to wait several minutes to obtain the output after marking a seed region. In FAST, tractography is formulated as a Markov chain that relies on a transition tensor. The tensor is designed to mimic the features of a well-known probabilistic tractography method based on a random walk model and Monte-Carlo sampling, but can also accommodate other propagation rules. Compared to the baseline algorithm, our method circumvents the sampling process and provides a deterministic solution at the expense of partially sacrificing sub-voxel accuracy. Therefore, the method is strictly speaking not stochastic, but provides a probabilistic output in the spirit of stochastic tractography methods. FAST was compared with the random walk model using real data from 10 patients in two different ways: 1. the probability maps produced by the two methods on five well-known fiber tracts were directly compared using metrics from the image registration literature; and 2. the connectivity measurements between different regions of the brain given by the two methods were compared using the correlation coefficient ρ. The results show that the connectivity measures provided by the two algorithms are well-correlated (ρ = 0.83), and so are the probability maps (normalized cross correlation 0.818 ± 0.081). The maps are also qualitatively (i.e., visually) very similar. The proposed method achieves a 60x speed-up (7 s vs. 7 min) over the Monte Carlo sampling scheme, therefore

  18. Fast dual tomography

    NASA Astrophysics Data System (ADS)

    Carrion, Philip M.

    1990-09-01

    This paper can be considered as a continuation of the work by Carrion and Carneiro (1989), where a generalized approach to linearized inversion of geophysical data was developed. Their method allows one to incorporate virtually any constraints in the inversion and reformulate the problem in the dual space of Langrangian multipliers (see also Carrion, 1989a). The constrained tomography makes traveltime inversion robust: it automatically rejects “bad data” which correspond to solutions beyond the chosen constraints and allows one to start inversion with an arbitrary chosen initial model.In this paper, I will derive basic formulas for constrained tomographic imaging that can be used in such areas of geophysics as global mapping of the earth interior, exploration geophysics, etc. The method is fast: an example that will be shown in the paper took only 6 min. of VAX CPU time. Had the conventional least-squares matrix inversion been used it would have taken more than 10 hours of the CPU time to solve the same problem.

  19. Inherent robustness of discrete-time adaptive control systems

    NASA Technical Reports Server (NTRS)

    Ma, C. C. H.

    1986-01-01

    Global stability robustness with respect to unmodeled dynamics, arbitrary bounded internal noise, as well as external disturbance is shown to exist for a class of discrete-time adaptive control systems when the regressor vectors of these systems are persistently exciting. Although fast adaptation is definitely undesirable, so far as attaining the greatest amount of global stability robustness is concerned, slow adaptation is shown to be not necessarily beneficial. The entire analysis in this paper holds for systems with slowly varying return difference matrices; the plants in these systems need not be slowly varying.

  20. Robust levitation control for maglev systems with guaranteed bounded airgap.

    PubMed

    Xu, Jinquan; Chen, Ye-Hwa; Guo, Hong

    2015-11-01

    The robust control design problem for the levitation control of a nonlinear uncertain maglev system is considered. The uncertainty is (possibly) fast time-varying. The system has magnitude limitation on the airgap between the suspended chassis and the guideway in order to prevent undesirable contact. Furthermore, the (global) matching condition is not satisfied. After a three-step state transformation, a robust control scheme for the maglev vehicle is proposed, which is able to guarantee the uniform boundedness and uniform ultimate boundedness of the system, regardless of the uncertainty. The magnitude limitation of the airgap is guaranteed, regardless of the uncertainty.

  1. Hough transform for robust regression and automated detection

    NASA Astrophysics Data System (ADS)

    Ballester, P.

    1994-06-01

    The Hough transform is a robust algorithm for detecting multi-dimensional features in images and estimating their parameters. It is widely used in the domains of remote sensing and machine vision and could find number of applications in astrophysics. A general introduction to the Hough transform, its main variations and implementation techniques is provided. A Hough transform based robust regression method is discussed and analyzed. Also auto-adaptive, fast pattern recognition algorithms for the detection of echelle orders and automated arc line identification are presented.

  2. Robust Understanding of Statistical Variation

    ERIC Educational Resources Information Center

    Peters, Susan A.

    2011-01-01

    This paper presents a framework that captures the complexity of reasoning about variation in ways that are indicative of robust understanding and describes reasoning as a blend of design, data-centric, and modeling perspectives. Robust understanding is indicated by integrated reasoning about variation within each perspective and across…

  3. Robust Understanding of Statistical Variation

    ERIC Educational Resources Information Center

    Peters, Susan A.

    2011-01-01

    This paper presents a framework that captures the complexity of reasoning about variation in ways that are indicative of robust understanding and describes reasoning as a blend of design, data-centric, and modeling perspectives. Robust understanding is indicated by integrated reasoning about variation within each perspective and across…

  4. Robust, Optimal Subsonic Airfoil Shapes

    NASA Technical Reports Server (NTRS)

    Rai, Man Mohan

    2014-01-01

    A method has been developed to create an airfoil robust enough to operate satisfactorily in different environments. This method determines a robust, optimal, subsonic airfoil shape, beginning with an arbitrary initial airfoil shape, and imposes the necessary constraints on the design. Also, this method is flexible and extendible to a larger class of requirements and changes in constraints imposed.

  5. A Robust Biomarker

    NASA Technical Reports Server (NTRS)

    Westall, F.; Steele, A.; Toporski, J.; Walsh, M. M.; Allen, C. C.; Guidry, S.; McKay, D. S.; Gibson, E. K.; Chafetz, H. S.

    2000-01-01

    containing fossil biofilm, including the 3.5 b.y..-old carbonaceous cherts from South Africa and Australia. As a result of the unique compositional, structural and "mineralisable" properties of bacterial polymer and biofilms, we conclude that bacterial polymers and biofilms constitute a robust and reliable biomarker for life on Earth and could be a potential biomarker for extraterrestrial life.

  6. A Robust Biomarker

    NASA Technical Reports Server (NTRS)

    Westall, F.; Steele, A.; Toporski, J.; Walsh, M. M.; Allen, C. C.; Guidry, S.; McKay, D. S.; Gibson, E. K.; Chafetz, H. S.

    2000-01-01

    containing fossil biofilm, including the 3.5 b.y..-old carbonaceous cherts from South Africa and Australia. As a result of the unique compositional, structural and "mineralisable" properties of bacterial polymer and biofilms, we conclude that bacterial polymers and biofilms constitute a robust and reliable biomarker for life on Earth and could be a potential biomarker for extraterrestrial life.

  7. Facial symmetry in robust anthropometrics.

    PubMed

    Kalina, Jan

    2012-05-01

    Image analysis methods commonly used in forensic anthropology do not have desirable robustness properties, which can be ensured by robust statistical methods. In this paper, the face localization in images is carried out by detecting symmetric areas in the images. Symmetry is measured between two neighboring rectangular areas in the images using a new robust correlation coefficient, which down-weights regions in the face violating the symmetry. Raw images of faces without usual preliminary transformations are considered. The robust correlation coefficient based on the least weighted squares regression yields very promising results also in the localization of such faces, which are not entirely symmetric. Standard methods of statistical machine learning are applied for comparison. The robust correlation analysis can be applicable to other problems of forensic anthropology.

  8. The Current State of the System of Mechanisms of Realisation and Protection of the Rights of the Child: Conceptual and Legal Aspects

    ERIC Educational Resources Information Center

    Drozdova, Alexandra Michailowna; Gulakova, Violetta Yurevna; Ivanchenko, Elena Anatolevna; Lesnichenko, Inna Pavlovna; Tereshchenko, Elena Anatolevna

    2016-01-01

    The article is devoted to the analytical understanding of the problems in the field of realisation and protection of the rights of children in Russia to identify and highlight existing problems in order to try to remove shortcomings and embark on further development and improvement of the legal and social mechanisms for the protection of…

  9. The Effect of a Primary School Teachers, Trade Union on the Formation and Realisation of Policy in Greece: The Case of Teacher Evaluation Policy

    ERIC Educational Resources Information Center

    Stamelos, Georgios; Bartzakli, Marianna

    2013-01-01

    The purpose of this article is to analyse and interpret the effect of the primary school teachers' trade union in Greece insofar as the formation and realisation of education policy is concerned, and, more precisely, insofar as it concerns the issue of teacher evaluation. The research material used comes from the filing and analysis of the…

  10. Primary School Teachers' Inspection in Turkey: Primary School Teachers' Expectations about Inspectors' Guidance Roles and the Realisation Level of These Expectations

    ERIC Educational Resources Information Center

    Polat, Soner; Ugurlu, Celal Teyyar

    2008-01-01

    The aim of this research is to point out primary school teachers' expectations about inspectors' guidance roles and the realisation level of these expectations. The data used in this research that will be done in descriptive scanning model is collected from the views of primary school teachers selected randomly from Balikesir, Batman and Hatay.…

  11. Educational Family Background and the Realisation of Educational Career Intentions: Participation of German Upper Secondary Graduates in Higher Education over Time

    ERIC Educational Resources Information Center

    Weiss, Felix; Steininger, Hanna-Marei

    2013-01-01

    In this article, we evaluate the impact of social origin on the realisation of educational intentions at the time of becoming eligible for higher education in Germany. In general, we find high persistence of intentions and actual attendance of higher education. However, effects of parental education on the changes of educational intentions…

  12. The Effect of a Primary School Teachers, Trade Union on the Formation and Realisation of Policy in Greece: The Case of Teacher Evaluation Policy

    ERIC Educational Resources Information Center

    Stamelos, Georgios; Bartzakli, Marianna

    2013-01-01

    The purpose of this article is to analyse and interpret the effect of the primary school teachers' trade union in Greece insofar as the formation and realisation of education policy is concerned, and, more precisely, insofar as it concerns the issue of teacher evaluation. The research material used comes from the filing and analysis of the…

  13. A robust composite nonlinear control scheme for servomotor speed regulation

    NASA Astrophysics Data System (ADS)

    Huang, Yanwei; Cheng, Guoqing

    2015-01-01

    A parameterised design of robust composite nonlinear controller is proposed for typical second-order servo systems subject to unknown constant disturbance and control input saturation. The control law consists of a linear feedback part for achieving fast response, a nonlinear feedback part for suppressing the overshoot, and a disturbance-compensation mechanism for erasing the steady-state error. An extended state observer is adopted to estimate the unknown disturbance. The closed-loop stability is analysed theoretically. The control scheme is applied to the speed regulation of permanent magnet synchronous motor, and numerical simulations are carried out. The results confirm that the proposed control scheme can achieve fast, smooth, and accurate speed regulation, and has a certain degree of robustness with respect to the amplitude of disturbances and the perturbations of system parameters.

  14. AKT as locus of fragility in robust cancer system.

    PubMed

    Radisavljevic, Ziv

    2008-08-15

    Metastatic cancer is a complex positive feedback loop system. Such as system has a tendency to acquire extreme robustness. Signaling pathways controlling that robustness can fail completely if an essential element from the signaling is removed. That element is a locus of fragility. Targeting that locus represents the best way to target the cancer robustness. This prospect presents another locus of fragility in signaling complex system network, controlling the cell cycle progression through the PI3K/AKT/mTOR/RAN pathway and cell migration and angiogenesis through the VEGF/PI3K/AKT/NO/ICAM-1 pathway. The locus of fragility of these pathways is AKT, which is regulated by a balance of catalase/H2O2 or by AKT inhibitor. Tiny and trivial perturbations such as change in redox state in the cells by antioxidant enzyme catalase, scavenging H2O2 signaling molecule, regulates robust signaling molecule AKT, abolishing its phosporilation and inducing cascading failure of robust signaling pathways for cell growth, proliferation, migration, and angiogenesis. An anticancer effect of the antioxidant is achieved through the AKT locus, by abolishing signals from growth factors VEGF, HGF, HIF-1alpha and H2O2. Previously reported locus of fragility nitric oxide (NO) and locus AKT are close in the complex signaling interactome network, but they regulate distinct signaling modules. Simultaneously targeted loci represents new principles in cancer robustness chemotherapy by blocking cell proliferation, migration, angiogenesis and inducing rather slow then fast apoptosis leading to slow eradication of cancer.

  15. Robustness of airline route networks

    NASA Astrophysics Data System (ADS)

    Lordan, Oriol; Sallan, Jose M.; Escorihuela, Nuria; Gonzalez-Prieto, David

    2016-03-01

    Airlines shape their route network by defining their routes through supply and demand considerations, paying little attention to network performance indicators, such as network robustness. However, the collapse of an airline network can produce high financial costs for the airline and all its geographical area of influence. The aim of this study is to analyze the topology and robustness of the network route of airlines following Low Cost Carriers (LCCs) and Full Service Carriers (FSCs) business models. Results show that FSC hubs are more central than LCC bases in their route network. As a result, LCC route networks are more robust than FSC networks.

  16. Simple Robust Fixed Lag Smoothing

    DTIC Science & Technology

    1988-12-02

    SIMPLE ROBUST FIXED LAG SMOOTHING by ~N. D. Le R.D. Martin 4 TECHNICAL RlEPORT No. 149 December 1988 Department of Statistics, GN-22 Accesion For...frLsD1ist Special A- Z Simple Robust Fixed Lag Smoothing With Application To Radar Glint Noise * N. D. Le R. D. Martin Department of Statistics, GN...smoothers. The emphasis here is on fixed-lag smoothing , as opposed to the use of existing robust fixed interval smoothers (e.g., as in Martin, 1979

  17. Use of a genetic algorithm to analyze robust stability problems

    SciTech Connect

    Murdock, T.M.; Schmitendorf, W.E.; Forrest, S.

    1990-01-01

    This note resents a genetic algorithm technique for testing the stability of a characteristic polynomial whose coefficients are functions of unknown but bounded parameters. This technique is fast and can handle a large number of parametric uncertainties. We also use this method to determine robust stability margins for uncertain polynomials. Several benchmark examples are included to illustrate the two uses of the algorithm. 27 refs., 4 figs.

  18. Tractable Quantification of Metastability for Robust Bipedal Locomotion

    DTIC Science & Technology

    2015-06-01

    satisfaction of the requirements for the degree Doctor of Philosophy in Electrical and Computer Engineering by Cenk Oguz Saglam Committee in charge...ORGANIZATION NAME(S) AND ADDRESS(ES) University of California, Santa Barbara,Electrical and Computer Engineering Department,Santa Barbara,CA,93106 8...an algorithm for fast and accurate computation of our robustness metric was a crucial and necessary step. While the outcome of optimization depends on

  19. Probabilistic Source Separation for Robust Fetal Electrocardiography

    PubMed Central

    2013-01-01

    Blind source separation (BSS) techniques are widely used to extract signals of interest from a mixture with other signals, such as extracting fetal electrocardiogram (ECG) signals from noninvasive recordings on the maternal abdomen. These BSS techniques, however, typically lack possibilities to incorporate any prior knowledge on the mixing of the source signals. Particularly for fetal ECG signals, knowledge on the mixing is available based on the origin and propagation properties of these signals. In this paper, a novel source separation method is developed that combines the strengths and accuracy of BSS techniques with the robustness of an underlying physiological model of the fetal ECG. The method is developed within a probabilistic framework and yields an iterative convergence of the separation matrix towards a maximum a posteriori estimation, where in each iteration the latest estimate of the separation matrix is corrected towards a tradeoff between the BSS technique and the physiological model. The method is evaluated by comparing its performance with that of FastICA on both simulated and real multichannel fetal ECG recordings, demonstrating that the developed method outperforms FastICA in extracting the fetal ECG source signals. PMID:24363776

  20. BARCHAN: Blob Alignment for Robust CHromatographic ANalysis.

    PubMed

    Couprie, Camille; Duval, Laurent; Moreaud, Maxime; Hénon, Sophie; Tebib, Mélinda; Souchon, Vincent

    2017-02-10

    Two-dimensional gas chromatography (GC×GC) plays a central role into the elucidation of complex samples. The automation of the identification of peak areas is of prime interest to obtain a fast and repeatable analysis of chromatograms. To determine the concentration of compounds or pseudo-compounds, templates of blobs are defined and superimposed on a reference chromatogram. The templates then need to be modified when different chromatograms are recorded. In this study, we present a chromatogram and template alignment method based on peak registration called BARCHAN. Peaks are identified using a robust mathematical morphology tool. The alignment is performed by a probabilistic estimation of a rigid transformation along the first dimension, and a non-rigid transformation in the second dimension, taking into account noise, outliers and missing peaks in a fully automated way. Resulting aligned chromatograms and masks are presented on two datasets. The proposed algorithm proves to be fast and reliable. It significantly reduces the time to results for GC×GC analysis.

  1. Robust Portfolio Optimization Using Pseudodistances.

    PubMed

    Toma, Aida; Leoni-Aubin, Samuela

    2015-01-01

    The presence of outliers in financial asset returns is a frequently occurring phenomenon which may lead to unreliable mean-variance optimized portfolios. This fact is due to the unbounded influence that outliers can have on the mean returns and covariance estimators that are inputs in the optimization procedure. In this paper we present robust estimators of mean and covariance matrix obtained by minimizing an empirical version of a pseudodistance between the assumed model and the true model underlying the data. We prove and discuss theoretical properties of these estimators, such as affine equivariance, B-robustness, asymptotic normality and asymptotic relative efficiency. These estimators can be easily used in place of the classical estimators, thereby providing robust optimized portfolios. A Monte Carlo simulation study and applications to real data show the advantages of the proposed approach. We study both in-sample and out-of-sample performance of the proposed robust portfolios comparing them with some other portfolios known in literature.

  2. Robust Optimization of Biological Protocols

    PubMed Central

    Flaherty, Patrick; Davis, Ronald W.

    2015-01-01

    When conducting high-throughput biological experiments, it is often necessary to develop a protocol that is both inexpensive and robust. Standard approaches are either not cost-effective or arrive at an optimized protocol that is sensitive to experimental variations. We show here a novel approach that directly minimizes the cost of the protocol while ensuring the protocol is robust to experimental variation. Our approach uses a risk-averse conditional value-at-risk criterion in a robust parameter design framework. We demonstrate this approach on a polymerase chain reaction protocol and show that our improved protocol is less expensive than the standard protocol and more robust than a protocol optimized without consideration of experimental variation. PMID:26417115

  3. A robust chaotic algorithm for digital image steganography

    NASA Astrophysics Data System (ADS)

    Ghebleh, M.; Kanso, A.

    2014-06-01

    This paper proposes a new robust chaotic algorithm for digital image steganography based on a 3-dimensional chaotic cat map and lifted discrete wavelet transforms. The irregular outputs of the cat map are used to embed a secret message in a digital cover image. Discrete wavelet transforms are used to provide robustness. Sweldens' lifting scheme is applied to ensure integer-to-integer transforms, thus improving the robustness of the algorithm. The suggested scheme is fast, efficient and flexible. Empirical results are presented to showcase the satisfactory performance of our proposed steganographic scheme in terms of its effectiveness (imperceptibility and security) and feasibility. Comparison with some existing transform domain steganographic schemes is also presented.

  4. Robust controls with structured perturbations

    NASA Technical Reports Server (NTRS)

    Keel, Leehyun

    1993-01-01

    This final report summarizes the recent results obtained by the principal investigator and his coworkers on the robust stability and control of systems containing parametric uncertainty. The starting point is a generalization of Kharitonov's theorem obtained in 1989, and its generalization to the multilinear case, the singling out of extremal stability subsets, and other ramifications now constitutes an extensive and coherent theory of robust parametric stability that is summarized in the results contained here.

  5. Robustness Elasticity in Complex Networks

    PubMed Central

    Matisziw, Timothy C.; Grubesic, Tony H.; Guo, Junyu

    2012-01-01

    Network robustness refers to a network’s resilience to stress or damage. Given that most networks are inherently dynamic, with changing topology, loads, and operational states, their robustness is also likely subject to change. However, in most analyses of network structure, it is assumed that interaction among nodes has no effect on robustness. To investigate the hypothesis that network robustness is not sensitive or elastic to the level of interaction (or flow) among network nodes, this paper explores the impacts of network disruption, namely arc deletion, over a temporal sequence of observed nodal interactions for a large Internet backbone system. In particular, a mathematical programming approach is used to identify exact bounds on robustness to arc deletion for each epoch of nodal interaction. Elasticity of the identified bounds relative to the magnitude of arc deletion is assessed. Results indicate that system robustness can be highly elastic to spatial and temporal variations in nodal interactions within complex systems. Further, the presence of this elasticity provides evidence that a failure to account for nodal interaction can confound characterizations of complex networked systems. PMID:22808060

  6. Robust clustering by pruning outliers.

    PubMed

    Zhang, Jiang-She; Leung, Yiu-Wing

    2003-01-01

    In many applications of C-means clustering, the given data set often contains noisy points. These noisy points will affect the resulting clusters, especially if they are far away from the data points. In this paper, we develop a pruning approach for robust C-means clustering. This approach identifies and prunes the outliers based on the sizes and shapes of the clusters so that the resulting clusters are least affected by the outliers. The pruning approach is general, and it can improve the robustness of many existing C-means clustering methods. In particular, we apply the pruning approach to improve the robustness of hard C-means clustering, fuzzy C-means clustering, and deterministic-annealing C-means clustering. As a result, we obtain three clustering algorithms that are the robust versions of the existing ones. In addition, we integrate the pruning approach with the fuzzy approach and the possibilistic approach to design two new algorithms for robust C-means clustering. The numerical results demonstrate that the pruning approach can achieve good robustness.

  7. A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Tradeoff on Phenotype Robustness in Biological Networks Part II: Ecological Networks.

    PubMed

    Chen, Bor-Sen; Lin, Ying-Po

    2013-01-01

    In ecological networks, network robustness should be large enough to confer intrinsic robustness for tolerating intrinsic parameter fluctuations, as well as environmental robustness for resisting environmental disturbances, so that the phenotype stability of ecological networks can be maintained, thus guaranteeing phenotype robustness. However, it is difficult to analyze the network robustness of ecological systems because they are complex nonlinear partial differential stochastic systems. This paper develops a unifying mathematical framework for investigating the principles of both robust stabilization and environmental disturbance sensitivity in ecological networks. We found that the phenotype robustness criterion for ecological networks is that if intrinsic robustness + environmental robustness ≦ network robustness, then the phenotype robustness can be maintained in spite of intrinsic parameter fluctuations and environmental disturbances. These results in robust ecological networks are similar to that in robust gene regulatory networks and evolutionary networks even they have different spatial-time scales.

  8. How robust is a robust policy? A comparative analysis of alternative robustness metrics for supporting robust decision analysis.

    NASA Astrophysics Data System (ADS)

    Kwakkel, Jan; Haasnoot, Marjolijn

    2015-04-01

    In response to climate and socio-economic change, in various policy domains there is increasingly a call for robust plans or policies. That is, plans or policies that performs well in a very large range of plausible futures. In the literature, a wide range of alternative robustness metrics can be found. The relative merit of these alternative conceptualizations of robustness has, however, received less attention. Evidently, different robustness metrics can result in different plans or policies being adopted. This paper investigates the consequences of several robustness metrics on decision making, illustrated here by the design of a flood risk management plan. A fictitious case, inspired by a river reach in the Netherlands is used. The performance of this system in terms of casualties, damages, and costs for flood and damage mitigation actions is explored using a time horizon of 100 years, and accounting for uncertainties pertaining to climate change and land use change. A set of candidate policy options is specified up front. This set of options includes dike raising, dike strengthening, creating more space for the river, and flood proof building and evacuation options. The overarching aim is to design an effective flood risk mitigation strategy that is designed from the outset to be adapted over time in response to how the future actually unfolds. To this end, the plan will be based on the dynamic adaptive policy pathway approach (Haasnoot, Kwakkel et al. 2013) being used in the Dutch Delta Program. The policy problem is formulated as a multi-objective robust optimization problem (Kwakkel, Haasnoot et al. 2014). We solve the multi-objective robust optimization problem using several alternative robustness metrics, including both satisficing robustness metrics and regret based robustness metrics. Satisficing robustness metrics focus on the performance of candidate plans across a large ensemble of plausible futures. Regret based robustness metrics compare the

  9. Research of Stochastic Robustness: Results and conclusions

    NASA Technical Reports Server (NTRS)

    Marrison, Chris

    1995-01-01

    With stochastic robustness we are creating tools to design robust compensators for practical systems. During this year, the stochastic robustness research achieved the following results: refined the search tools needed for synthesis; successfully designed robust compensators for the American Controls Conference benchmark problem; and successfully designed robust compensators for a nonlinear hypersonic aircraft model with uncertainties in 28 parameters.

  10. Designing robust control laws using genetic algorithms

    NASA Technical Reports Server (NTRS)

    Marrison, Chris

    1994-01-01

    The purpose of this research is to create a method of finding practical, robust control laws. The robustness of a controller is judged by Stochastic Robustness metrics and the level of robustness is optimized by searching for design parameters that minimize a robustness cost function.

  11. Acid-fast stain

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/003766.htm Acid-fast stain To use the sharing features on this page, please enable JavaScript. The acid-fast stain is a laboratory test that determines ...

  12. Fast food (image)

    MedlinePlus

    Fast foods are quick, reasonably priced, and readily available alternatives to home cooking. While convenient and economical for a busy lifestyle, fast foods are typically high in calories, fat, saturated ...

  13. Realising the Vision

    ERIC Educational Resources Information Center

    Fullick, Leisha; Field, John; Rees, Teresa; Gilchrist, Helen

    2009-01-01

    The Inquiry into the Future for Lifelong Learning proposes a strategy for lifelong learning for the next quarter-century. In this article, four of the Inquiry's commissioners--Leisha Fullick, John Field, Teresa Rees and Helen Gilchrist--reflect on some of the report's key themes. Fullick discusses the role of "local responsiveness" in…

  14. Realising the Vision

    ERIC Educational Resources Information Center

    Fullick, Leisha; Field, John; Rees, Teresa; Gilchrist, Helen

    2009-01-01

    The Inquiry into the Future for Lifelong Learning proposes a strategy for lifelong learning for the next quarter-century. In this article, four of the Inquiry's commissioners--Leisha Fullick, John Field, Teresa Rees and Helen Gilchrist--reflect on some of the report's key themes. Fullick discusses the role of "local responsiveness" in…

  15. Degree Apprenticeships: Realising Opportunities

    ERIC Educational Resources Information Center

    Universities UK, 2017

    2017-01-01

    This report represents a follow-up study to a March 2016 report, "The Future Growth of Degree Apprenticeships" (ED574134), an assessment of university engagement with the very early stages of the development of degree apprenticeships. This follow-up study draws on an extensive survey of what universities are now doing and plan to do. The…

  16. Is fast food addictive?

    PubMed

    Garber, Andrea K; Lustig, Robert H

    2011-09-01

    Studies of food addiction have focused on highly palatable foods. While fast food falls squarely into that category, it has several other attributes that may increase its salience. This review examines whether the nutrients present in fast food, the characteristics of fast food consumers or the presentation and packaging of fast food may encourage substance dependence, as defined by the American Psychiatric Association. The majority of fast food meals are accompanied by a soda, which increases the sugar content 10-fold. Sugar addiction, including tolerance and withdrawal, has been demonstrated in rodents but not humans. Caffeine is a "model" substance of dependence; coffee drinks are driving the recent increase in fast food sales. Limited evidence suggests that the high fat and salt content of fast food may increase addictive potential. Fast food restaurants cluster in poorer neighborhoods and obese adults eat more fast food than those who are normal weight. Obesity is characterized by resistance to insulin, leptin and other hormonal signals that would normally control appetite and limit reward. Neuroimaging studies in obese subjects provide evidence of altered reward and tolerance. Once obese, many individuals meet criteria for psychological dependence. Stress and dieting may sensitize an individual to reward. Finally, fast food advertisements, restaurants and menus all provide environmental cues that may trigger addictive overeating. While the concept of fast food addiction remains to be proven, these findings support the role of fast food as a potentially addictive substance that is most likely to create dependence in vulnerable populations.

  17. Realisation and advanced engineering of true optical rugate filters based on nanoporous anodic alumina by sinusoidal pulse anodisation

    NASA Astrophysics Data System (ADS)

    Santos, Abel; Yoo, Jeong Ha; Rohatgi, Charu Vashisth; Kumeria, Tushar; Wang, Ye; Losic, Dusan

    2016-01-01

    This study is the first realisation of true optical rugate filters (RFs) based on nanoporous anodic alumina (NAA) by sinusoidal waves. An innovative and rationally designed sinusoidal pulse anodisation (SPA) approach in galvanostatic mode is used with the aim of engineering the effective medium of NAA in a sinusoidal fashion. A precise control over the different anodisation parameters (i.e. anodisation period, anodisation amplitude, anodisation offset, number of pulses, anodisation temperature and pore widening time) makes it possible to engineer the characteristic reflection peaks and interferometric colours of NAA-RFs, which can be finely tuned across the UV-visible-NIR spectrum. The effect of the aforementioned anodisation parameters on the photonic properties of NAA-RFs (i.e. characteristic reflection peaks and interferometric colours) is systematically assessed in order to establish for the first time a comprehensive rationale towards NAA-RFs with fully controllable photonic properties. The experimental results are correlated with a theoretical model (Looyenga-Landau-Lifshitz - LLL), demonstrating that the effective medium of these photonic nanostructures can be precisely described by the effective medium approximation. NAA-RFs are also demonstrated as chemically selective photonic platforms combined with reflectometric interference spectroscopy (RIfS). The resulting optical sensing system is used to assess the reversible binding affinity between a model drug (i.e. indomethacin) and human serum albumin (HSA) in real-time. Our results demonstrate that this system can be used to determine the overall pharmacokinetic profile of drugs, which is a critical aspect to be considered for the implementation of efficient medical therapies.This study is the first realisation of true optical rugate filters (RFs) based on nanoporous anodic alumina (NAA) by sinusoidal waves. An innovative and rationally designed sinusoidal pulse anodisation (SPA) approach in galvanostatic

  18. Realisation de guides d'onde plans faibles pertes en nitrure de silicium pour un biocapteur integre

    NASA Astrophysics Data System (ADS)

    Gorin, Arnaud

    Le nitrure de silicium est un materiau tres utilise en microelectronique et en optique integree due a l'excellente homogeneite et reproductibilite de son epaisseur et de son indice de refraction. De plus, l'indice de refraction eleve du nitrure de silicium est particulierement interessant pour les applications en biophotonique. En effet, ces dernieres annees les biocapteurs a champ evanescent ont demontre une augmentation de la sensibilite avec l'utilisation de guides d'onde plans a haut indice de refraction. La sensibilite pourrait etre encore amelioree en integrant sur un meme substrat l'ensemble des composants passifs et actifs (Lab-on-a-chip) qui composent le biocapteur a champ evanescent. L'integration des differents composants optiques passe par la fabrication d'un guide d'onde plan dans le visible qui soit realise avec des procedes a basse temperature, faible epaisseur, faible perte et haut indice de refraction. Meme si les couches d'oxyde metallique (TiO2, Ta2O5 par exemple), generalement utilisees pour ce type d'application, permettent d'obtenir de bonnes proprietes optiques, elles ne permettent pas d'atteindre la qualite des couches en nitrure de silicium notamment en termes de rugosite de surface pour de faibles epaisseurs. Dans le cadre de ces travaux de doctorat, les parametres du guide d'onde sont optimises pour une application utilisant des fluorophores a points quantiques emettant a 650 nm et excites avec une source laser a 532 nm. Une epaisseur de 80 nm est determinee comme optimale pour l'excitation, la collection de la fluorescence et le couplage fibre-guide. Le developpement d'un guide d'onde capable d'atteindre cette epaisseur et conservant des bonnes proprietes optiques est necessaire. A notre connaissance aucun travail n'a ete realise pour optimiser les pertes dans le visible des guides de nitrure de silicium, en fonction des parametres du procede PECVD. Dans ce travail de these, des guides d'onde sont fabriques pour la premiere fois en

  19. Robust (semi) nonnegative graph embedding.

    PubMed

    Zhang, Hanwang; Zha, Zheng-Jun; Yang, Yang; Yan, Shuicheng; Chua, Tat-Seng

    2014-07-01

    Nonnegative matrix factorization (NMF) has received considerable attention in image processing, computer vision, and patter recognition. An important variant of NMF is nonnegative graph embedding (NGE), which encodes the statistical or geometric information of data in the process of matrix factorization. The NGE offers a general framework for unsupervised/supervised settings. However, NGE-like algorithms often suffer from noisy data, unreliable graphs, and noisy labels, which are commonly encountered in real-world applications. To address these issues, in this paper, we first propose a robust nonnegative graph embedding (RNGE) framework, where the joint sparsity in both graph embedding and data reconstruction endues robustness to undesirable noises. Next, we present a robust seminonnegative graph embedding (RsNGE) framework, which only constrains the coefficient matrix to be nonnegative while places no constraint on the base matrix. This extends the applicable range of RNGE to data which are not nonnegative and endows more discriminative power of the learnt base matrix. The RNGE/RsNGE provides a general formulation such that all the algorithms unified within the graph embedding framework can be easily extended to obtain their robust nonnegative/seminonnegative solutions. Further, we develop elegant multiplicative updating solutions that can solve RNGE/RsNGE efficiently and offer a rigorous convergence analysis. We conduct extensive experiments on four real-world data sets and compare the proposed RNGE/RsNGE to other representative NMF variants and data factorization methods. The experimental results demonstrate the robustness and effectiveness of the proposed approaches.

  20. FastMotif: spectral sequence motif discovery.

    PubMed

    Colombo, Nicoló; Vlassis, Nikos

    2015-08-15

    Sequence discovery tools play a central role in several fields of computational biology. In the framework of Transcription Factor binding studies, most of the existing motif finding algorithms are computationally demanding, and they may not be able to support the increasingly large datasets produced by modern high-throughput sequencing technologies. We present FastMotif, a new motif discovery algorithm that is built on a recent machine learning technique referred to as Method of Moments. Based on spectral decompositions, our method is robust to model misspecifications and is not prone to locally optimal solutions. We obtain an algorithm that is extremely fast and designed for the analysis of big sequencing data. On HT-Selex data, FastMotif extracts motif profiles that match those computed by various state-of-the-art algorithms, but one order of magnitude faster. We provide a theoretical and numerical analysis of the algorithm's robustness and discuss its sensitivity with respect to the free parameters. The Matlab code of FastMotif is available from http://lcsb-portal.uni.lu/bioinformatics. vlassis@adobe.com Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  1. From bench to application: current practices in tissue engineering and its realisation at maxillofacial units in Germany, Austria and Switzerland.

    PubMed

    Smeets, Ralf; El-Moawen, Ahmed; Jung, Ole; Hanken, Henning; Hartjen, Philip; Heiland, Max; Kansy, Katinka; Kloss, Frank; Kolk, Andreas

    2014-10-01

    Over the last 20 years, the highly interdisciplinary field of tissue engineering (TE) has become an established subspecialty in research facilities all over the world. Numerous methods and protocols are available for various research intentions and aims, but there are no data indicating which of these methods and resources are generally used. This study is an overview of the resources and methods that are commonly applied in TE research in general, and in the field of oral and maxillofacial surgery (OMFS) in Germany, Austria and Switzerland. The DÖSAK collaborative group for TE developed a detailed questionnaire and collected information from participating university hospitals in these three countries. We evaluated the availability of research facilities, in vitro realisation and in vivo designs for animal studies in these departments. 11 units who replied, out of 35 we contacted, conducted research on bone regeneration in interdisciplinary research facilities. 10 departments used xenogeneic and alloplastic scaffolds for in vitro and in vivo applications. In this case, the most commonly utilised trademarks were Bio-Oss(®) and CERASORB(®). 9 units used osteoblasts (73%) and 10 proliferation assays in vitro, whereas rats served as the standard animal model for histology/immunohistochemistry in 6. All research units were interested in establishing a platform for research exchange and communication. This study shows that tissue engineering is well established and highly accepted in most participating university hospitals and research facilities. The presented data, together with data published in a foregoing paper will help arrange more readily available standardised procedures for further investigations. Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  2. Cardiovascular risk profile and management of atrial fibrillation in India: Real world data from RealiseAF survey.

    PubMed

    Narasimhan, C; Verma, Jagmohan Singh; Ravi Kishore, A G; Singh, Balbir; Dani, Sameer; Chawala, Kamaldeep; Haque, Azizul; Khan, Aftab; Nair, Mohan; Vora, Amit; Rajasekhar, V; Thomas, Joy M; Gupta, Anoop; Naik, Ajay; Prakash, V S; Naditch, Lisa; Gabriel Steg, P

    Atrial fibrillation (AF) is the most common sustained arrhythmia with high risk for many cardiovascular (CV) complications. Adherence to recommended management guidelines is important to avoid complications. In India, there is little knowledge on how AF is managed in real world. This is a cross-sectional study of patients in India enrolled in RealiseAF survey between February 2010 and March 2010 with a diagnosis of AF within the last 12 months. From 15 centers, 301 patients {mean age 59.9 years (14.4); 52.5% males} were recruited. AF was controlled in 50% of patients with 77 (26.7%) in sinus rhythm and 67 (23.3%) with heart rate <80beats/min. Hypertension (50.8%), valvular heart disease (40.7%), heart failure (25.9%), and diabetes (20.4%) were the most common underlying CV diseases. Increased risk for stroke (CHADS2 score≥2) was present in 36.6%. Most of the patients (85%) were symptomatic. AF was paroxysmal, persistent, and permanent in 28.7%, 22.7%, and 34.3% respectively. In 14%, AF was diagnosed as first episode. Forty-six percent of patients had rate control, 35.2% rhythm control, 0.3% both strategies, and 18.4% received no therapy for AF before the visit. At the end of the visit, adoption to rate control strategy increased to 52.3% and patients with no therapy decreased to 7%. AF in India is not adequately controlled. Concomitant CV risk factors and risk of stroke are high. The study underscores the need for improved adoption of guideline-directed management for optimal control of AF and reducing the risk of stroke. Copyright © 2016. Published by Elsevier B.V.

  3. Robust Hitting with Dynamics Shaping

    NASA Astrophysics Data System (ADS)

    Yashima, Masahito; Yamawaki, Tasuku

    The present paper proposes the trajectory planning based on “the dynamics shaping” for a redundant robotic arm to hit a target robustly toward the desired direction, of which the concept is to shape the robot dynamics appropriately by changing its posture in order to achieve the robust motion. The positional error of the end-effector caused by unknown disturbances converges onto near the singular vector corresponding to its maximum singular value of the output controllability matrix of the robotic arm. Therefore, if we can control the direction of the singular vector by applying the dynamics shaping, we will be able to control the direction of the positional error of the end-effector caused by unknown disturbances. We propose a novel trajectory planning based on the dynamics shaping and verify numerically and experimentally that the robotic arm can robustly hit the target toward the desired direction with a simple open-loop control system even though the disturbance is applied.

  4. Operating ITER Robustly Without Disruptions

    NASA Astrophysics Data System (ADS)

    Humphreys, D. A.; Eidietis, N. W.; Hyatt, A. W.; Leuer, J. A.; Luce, T. C.; Strait, E. J.; Walker, M. L.; Welander, A. S.; Wesley, J. C.; Lodestro, L.; Pearlstein, L. D.

    2011-10-01

    Disruptivity in ITER must be minimized to limit downtime and maximize use of the limited number of discharges. Minimizing disruptivity requires sufficient control capability, including robustness to disturbances and disruption avoidance through prediction of controllability limits. Robust control implies a balance of passively stable nominal scenarios, robust operation near or beyond open loop stability limits, and responses to off-normal events to avoid disruptive termination. Such a solution is possible because disruptions result from deterministic loss of controllability due to many proximal causes (e.g. loss of hardware resources, human error, or uncontrollable disturbances), most of which can be addressed with good physics models and known control methods. We illustrate the required approach with DIII-D experiments to assess ITER controllability and pre-qualify ITER scenarios, and with design and analysis ensuring sufficiently robust vertical control for ITER. Supported by the US DOE under DE-FC02-04ER54698 and DE-AC52-07NA27344.

  5. Network Robustness: the whole story

    NASA Astrophysics Data System (ADS)

    Longjas, A.; Tejedor, A.; Zaliapin, I. V.; Ambroj, S.; Foufoula-Georgiou, E.

    2014-12-01

    A multitude of actual processes operating on hydrological networks may exhibit binary outcomes such as clean streams in a river network that may become contaminated. These binary outcomes can be modeled by node removal processes (attacks) acting in a network. Network robustness against attacks has been widely studied in fields as diverse as the Internet, power grids and human societies. However, the current definition of robustness is only accounting for the connectivity of the nodes unaffected by the attack. Here, we put forward the idea that the connectivity of the affected nodes can play a crucial role in proper evaluation of the overall network robustness and its future recovery from the attack. Specifically, we propose a dual perspective approach wherein at any instant in the network evolution under attack, two distinct networks are defined: (i) the Active Network (AN) composed of the unaffected nodes and (ii) the Idle Network (IN) composed of the affected nodes. The proposed robustness metric considers both the efficiency of destroying the AN and the efficiency of building-up the IN. This approach is motivated by concrete applied problems, since, for example, if we study the dynamics of contamination in river systems, it is necessary to know both the connectivity of the healthy and contaminated parts of the river to assess its ecological functionality. We show that trade-offs between the efficiency of the Active and Idle network dynamics give rise to surprising crossovers and re-ranking of different attack strategies, pointing to significant implications for decision making.

  6. Robust design of dynamic observers

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, S. P.

    1974-01-01

    The two (identity) observer realizations z = Mz + Ky and z = transpose of Az + transpose of K(y - transpose of Cz), respectively called the open loop and closed loop realizations, for the linear system x = Ax, y = Cx are analyzed with respect to the requirement of robustness; i.e., the requirement that the observer continue to regulate the error x - z satisfactorily despite small variations in the observer parameters from the projected design values. The results show that the open loop realization is never robust, that robustness requires a closed loop implementation, and that the closed loop realization is robust with respect to small perturbations in the gains transpose of K if and only if the observer can be built to contain an exact replica of the unstable and underdamped dynamics of the system being observed. These results clarify the stringent accuracy requirements on both models and hardware that must be met before an observer can be considered for use in a control system.

  7. Starfish: Robust spectroscopic inference tools

    NASA Astrophysics Data System (ADS)

    Czekala, Ian; Andrews, Sean M.; Mandel, Kaisey S.; Hogg, David W.; Green, Gregory M.

    2015-05-01

    Starfish is a set of tools used for spectroscopic inference. It robustly determines stellar parameters using high resolution spectral models and uses Markov Chain Monte Carlo (MCMC) to explore the full posterior probability distribution of the stellar parameters. Additional potential applications include other types of spectra, such as unresolved stellar clusters or supernovae spectra.

  8. Mental Models: A Robust Definition

    ERIC Educational Resources Information Center

    Rook, Laura

    2013-01-01

    Purpose: The concept of a mental model has been described by theorists from diverse disciplines. The purpose of this paper is to offer a robust definition of an individual mental model for use in organisational management. Design/methodology/approach: The approach adopted involves an interdisciplinary literature review of disciplines, including…

  9. Mental Models: A Robust Definition

    ERIC Educational Resources Information Center

    Rook, Laura

    2013-01-01

    Purpose: The concept of a mental model has been described by theorists from diverse disciplines. The purpose of this paper is to offer a robust definition of an individual mental model for use in organisational management. Design/methodology/approach: The approach adopted involves an interdisciplinary literature review of disciplines, including…

  10. Shaping robust system through evolution

    NASA Astrophysics Data System (ADS)

    Kaneko, Kunihiko

    2008-06-01

    Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the phenotype. Here we study how this dynamical system is robust to noise during development and to genetic change by mutation. We adopt a simplified transcription regulation network model to govern gene expression, which gives a fitness function. Through simulations of the network that undergoes mutation and selection, we show that a certain level of noise in gene expression is required for the network to acquire both types of robustness. The results reveal how the noise that cells encounter during development shapes any network's robustness, not only to noise but also to mutations. We also establish a relationship between developmental and mutational robustness through phenotypic variances caused by genetic variation and epigenetic noise. A universal relationship between the two variances is derived, akin to the fluctuation-dissipation relationship known in physics.

  11. Robust Portfolio Optimization Using Pseudodistances

    PubMed Central

    2015-01-01

    The presence of outliers in financial asset returns is a frequently occurring phenomenon which may lead to unreliable mean-variance optimized portfolios. This fact is due to the unbounded influence that outliers can have on the mean returns and covariance estimators that are inputs in the optimization procedure. In this paper we present robust estimators of mean and covariance matrix obtained by minimizing an empirical version of a pseudodistance between the assumed model and the true model underlying the data. We prove and discuss theoretical properties of these estimators, such as affine equivariance, B-robustness, asymptotic normality and asymptotic relative efficiency. These estimators can be easily used in place of the classical estimators, thereby providing robust optimized portfolios. A Monte Carlo simulation study and applications to real data show the advantages of the proposed approach. We study both in-sample and out-of-sample performance of the proposed robust portfolios comparing them with some other portfolios known in literature. PMID:26468948

  12. Robust template matching using run-length encoding

    NASA Astrophysics Data System (ADS)

    Lee, Hunsue; Suh, Sungho; Cho, Hansang

    2015-09-01

    In this paper we propose a novel template matching algorithm for visual inspection of bare printed circuit board (PCB).1 In the conventional template matching for PCB inspection, the matching score and its relevant offsets are acquired by calculating the maximum value among the convolutions of template image and camera image. While the method is fast, the robustness and accuracy of matching are not guaranteed due to the gap between a design and an implementation resulting from defects and process variations. To resolve this problem, we suggest a new method which uses run-length encoding (RLE). For the template image to be matched, we accumulate data of foreground and background, and RLE data for each row and column in the template image. Using the data, we can find the x and y offsets which minimize the optimization function. The efficiency and robustness of the proposed algorithm are verified through a series of experiments. By comparing the proposed algorithm with the conventional approach, we could realize that the proposed algorithm is not only fast but also more robust and reliable in matching results.

  13. Clinical Characteristics, Management, and Control of Permanent vs. Nonpermanent Atrial Fibrillation: Insights from the RealiseAF Survey

    PubMed Central

    Murin, Jan; Naditch-Brûlé, Lisa; Brette, Sandrine; Chiang, Chern-En; O’Neill, James; Steg, P. Gabriel

    2014-01-01

    Background Atrial fibrillation can be categorized into nonpermanent and permanent atrial fibrillation. There is less information on permanent than on nonpermanent atrial fibrillation patients. This analysis aimed to describe the characteristics and current management, including the proportion of patients with successful atrial fibrillation control, of these atrial fibrillation subsets in a large, geographically diverse contemporary sample. Methods and Results Data from RealiseAF, an international, observational, cross-sectional survey of 10,491 patients with atrial fibrillation, were used to characterize permanent atrial fibrillation (N = 4869) and nonpermanent atrial fibrillation (N = 5622) patients. Permanent atrial fibrillation patients were older, had a longer time since atrial fibrillation diagnosis, a higher symptom burden, and were more likely to be physically inactive. They also had a higher mean (SD) CHADS2 score (2.2 [1.3] vs. 1.7 [1.3], p<0.001), and a higher frequency of CHADS2 score ≥2 (67.3% vs. 53.0%, p<0.001) and comorbidities, most notably heart failure. Physicians indicated using a rate-control strategy in 84.2% of permanent atrial fibrillation patients (vs. 27.5% in nonpermanent atrial fibrillation). Only 50.2% (N = 2262/4508) of permanent atrial fibrillation patients were controlled. These patients had a longer time since atrial fibrillation diagnosis, a lower symptom burden, less obesity and physical inactivity, less severe heart failure, and fewer hospitalizations for acute heart failure than uncontrolled permanent atrial fibrillation patients, but with more arrhythmic events. The most frequent causes of hospitalization in the last 12 months were acute heart failure and stroke. Conclusion Permanent atrial fibrillation is a high-risk subset of atrial fibrillation, representing half of all atrial fibrillation patients, yet rate control is only achieved in around half. Since control is associated with lower symptom burden and heart

  14. The role of biotic interactions in shaping distributions and realised assemblages of species: implications for species distribution modelling

    PubMed Central

    Wisz, Mary Susanne; Pottier, Julien; Kissling, W Daniel; Pellissier, Loïc; Lenoir, Jonathan; Damgaard, Christian F; Dormann, Carsten F; Forchhammer, Mads C; Grytnes, John-Arvid; Guisan, Antoine; Heikkinen, Risto K; Høye, Toke T; Kühn, Ingolf; Luoto, Miska; Maiorano, Luigi; Nilsson, Marie-Charlotte; Normand, Signe; Öckinger, Erik; Schmidt, Niels M; Termansen, Mette; Timmermann, Allan; Wardle, David A; Aastrup, Peter; Svenning, Jens-Christian

    2013-01-01

    Predicting which species will occur together in the future, and where, remains one of the greatest challenges in ecology, and requires a sound understanding of how the abiotic and biotic environments interact with dispersal processes and history across scales. Biotic interactions and their dynamics influence species' relationships to climate, and this also has important implications for predicting future distributions of species. It is already well accepted that biotic interactions shape species' spatial distributions at local spatial extents, but the role of these interactions beyond local extents (e.g. 10 km2 to global extents) are usually dismissed as unimportant. In this review we consolidate evidence for how biotic interactions shape species distributions beyond local extents and review methods for integrating biotic interactions into species distribution modelling tools. Drawing upon evidence from contemporary and palaeoecological studies of individual species ranges, functional groups, and species richness patterns, we show that biotic interactions have clearly left their mark on species distributions and realised assemblages of species across all spatial extents. We demonstrate this with examples from within and across trophic groups. A range of species distribution modelling tools is available to quantify species environmental relationships and predict species occurrence, such as: (i) integrating pairwise dependencies, (ii) using integrative predictors, and (iii) hybridising species distribution models (SDMs) with dynamic models. These methods have typically only been applied to interacting pairs of species at a single time, require a priori ecological knowledge about which species interact, and due to data paucity must assume that biotic interactions are constant in space and time. To better inform the future development of these models across spatial scales, we call for accelerated collection of spatially and temporally explicit species data. Ideally

  15. fast-matmul

    SciTech Connect

    Grey Ballard, Austin Benson

    2014-11-26

    This software provides implementations of fast matrix multiplication algorithms. These algorithms perform fewer floating point operations than the classical cubic algorithm. The software uses code generation to automatically implement the fast algorithms based on high-level descriptions. The code serves two general purposes. The first is to demonstrate that these fast algorithms can out-perform vendor matrix multiplication algorithms for modest problem sizes on a single machine. The second is to rapidly prototype many variations of fast matrix multiplication algorithms to encourage future research in this area. The implementations target sequential and shared memory parallel execution.

  16. Fast wave current drive

    SciTech Connect

    Goree, J.; Ono, M.; Colestock, P.; Horton, R.; McNeill, D.; Park, H.

    1985-07-01

    Fast wave current drive is demonstrated in the Princeton ACT-I toroidal device. The fast Alfven wave, in the range of high ion-cyclotron harmonics, produced 40 A of current from 1 kW of rf power coupled into the plasma by fast wave loop antenna. This wave excites a steady current by damping on the energetic tail of the electron distribution function in the same way as lower-hybrid current drive, except that fast wave current drive is appropriate for higher plasma densities.

  17. Punctuated evolution and robustness in morphogenesis.

    PubMed

    Grigoriev, D; Reinitz, J; Vakulenko, S; Weber, A

    2014-09-01

    This paper presents an analytic approach to the pattern stability and evolution problem in morphogenesis. The approach used here is based on the ideas from the gene and neural network theory. We assume that gene networks contain a number of small groups of genes (called hubs) controlling morphogenesis process. Hub genes represent an important element of gene network architecture and their existence is empirically confirmed. We show that hubs can stabilize morphogenetic pattern and accelerate the morphogenesis. The hub activity exhibits an abrupt change depending on the mutation frequency. When the mutation frequency is small, these hubs suppress all mutations and gene product concentrations do not change, thus, the pattern is stable. When the environmental pressure increases and the population needs new genotypes, the genetic drift and other effects increase the mutation frequency. For the frequencies that are larger than a critical amount the hubs turn off; and as a result, many mutations can affect phenotype. This effect can serve as an engine for evolution. We show that this engine is very effective: the evolution acceleration is an exponential function of gene redundancy. Finally, we show that the Eldredge-Gould concept of punctuated evolution results from the network architecture, which provides fast evolution, control of evolvability, and pattern robustness. To describe analytically the effect of exponential acceleration, we use mathematical methods developed recently for hard combinatorial problems, in particular, for so-called k-SAT problem, and numerical simulations. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. Punctuated evolution and robustness in morphogenesis

    PubMed Central

    Grigoriev, D.; Reinitz, J.; Vakulenko, S.; Weber, A.

    2014-01-01

    This paper presents an analytic approach to the pattern stability and evolution problem in morphogenesis. The approach used here is based on the ideas from the gene and neural network theory. We assume that gene networks contain a number of small groups of genes (called hubs) controlling morphogenesis process. Hub genes represent an important element of gene network architecture and their existence is empirically confirmed. We show that hubs can stabilize morphogenetic pattern and accelerate the morphogenesis. The hub activity exhibits an abrupt change depending on the mutation frequency. When the mutation frequency is small, these hubs suppress all mutations and gene product concentrations do not change, thus, the pattern is stable. When the environmental pressure increases and the population needs new genotypes, the genetic drift and other effects increase the mutation frequency. For the frequencies that are larger than a critical amount the hubs turn off; and as a result, many mutations can affect phenotype. This effect can serve as an engine for evolution. We show that this engine is very effective: the evolution acceleration is an exponential function of gene redundancy. Finally, we show that the Eldredge-Gould concept of punctuated evolution results from the network architecture, which provides fast evolution, control of evolvability, and pattern robustness. To describe analytically the effect of exponential acceleration, we use mathematical methods developed recently for hard combinatorial problems, in particular, for so-called k-SAT problem, and numerical simulations. PMID:24996115

  19. Integrative Physiology of Fasting.

    PubMed

    Secor, Stephen M; Carey, Hannah V

    2016-03-15

    Extended bouts of fasting are ingrained in the ecology of many organisms, characterizing aspects of reproduction, development, hibernation, estivation, migration, and infrequent feeding habits. The challenge of long fasting episodes is the need to maintain physiological homeostasis while relying solely on endogenous resources. To meet that challenge, animals utilize an integrated repertoire of behavioral, physiological, and biochemical responses that reduce metabolic rates, maintain tissue structure and function, and thus enhance survival. We have synthesized in this review the integrative physiological, morphological, and biochemical responses, and their stages, that characterize natural fasting bouts. Underlying the capacity to survive extended fasts are behaviors and mechanisms that reduce metabolic expenditure and shift the dependency to lipid utilization. Hormonal regulation and immune capacity are altered by fasting; hormones that trigger digestion, elevate metabolism, and support immune performance become depressed, whereas hormones that enhance the utilization of endogenous substrates are elevated. The negative energy budget that accompanies fasting leads to the loss of body mass as fat stores are depleted and tissues undergo atrophy (i.e., loss of mass). Absolute rates of body mass loss scale allometrically among vertebrates. Tissues and organs vary in the degree of atrophy and downregulation of function, depending on the degree to which they are used during the fast. Fasting affects the population dynamics and activities of the gut microbiota, an interplay that impacts the host's fasting biology. Fasting-induced gene expression programs underlie the broad spectrum of integrated physiological mechanisms responsible for an animal's ability to survive long episodes of natural fasting. Copyright © 2016 John Wiley & Sons, Inc.

  20. A Robust Streaming Media System

    NASA Astrophysics Data System (ADS)

    Youwei, Zhang

    Presently, application layer multicast protocols (ALM) are proposed as substitute for IP multicast and have made extraordinary achievements. Integrated with Multi-data-stream mode such as Multiple Description Coding (MDC), ALM becomes more scalable and robust in high-dynamic Internet environment compared with single data stream. Although MDC can provide a flexible data transmission style, the synchronization of different descriptions encoded from one video source is proved to be difficult due to different delay on diverse transmission paths. In this paper, an ALM system called HMDC is proposed to improve accepted video quality of streaming media, hosts can join the separate overlay trees in different layers simultaneously, then the maximum synchronized descriptions of the same layer are worked out to acquire the best video quality. Simulations implemented on Internet-like topology indicate that HMDC achieves better video quality, lower link stress, higher robustness and comparable latency compared with traditional ALM protocols.

  1. Robust background modelling in DIALS

    PubMed Central

    Parkhurst, James M.; Winter, Graeme; Waterman, David G.; Fuentes-Montero, Luis; Gildea, Richard J.; Murshudov, Garib N.; Evans, Gwyndaf

    2016-01-01

    A method for estimating the background under each reflection during integration that is robust in the presence of pixel outliers is presented. The method uses a generalized linear model approach that is more appropriate for use with Poisson distributed data than traditional approaches to pixel outlier handling in integration programs. The algorithm is most applicable to data with a very low background level where assumptions of a normal distribution are no longer valid as an approximation to the Poisson distribution. It is shown that traditional methods can result in the systematic underestimation of background values. This then results in the reflection intensities being overestimated and gives rise to a change in the overall distribution of reflection intensities in a dataset such that too few weak reflections appear to be recorded. Statistical tests performed during data reduction may mistakenly attribute this to merohedral twinning in the crystal. Application of the robust generalized linear model algorithm is shown to correct for this bias. PMID:27980508

  2. Algebraic connectivity and graph robustness.

    SciTech Connect

    Feddema, John Todd; Byrne, Raymond Harry; Abdallah, Chaouki T.

    2009-07-01

    Recent papers have used Fiedler's definition of algebraic connectivity to show that network robustness, as measured by node-connectivity and edge-connectivity, can be increased by increasing the algebraic connectivity of the network. By the definition of algebraic connectivity, the second smallest eigenvalue of the graph Laplacian is a lower bound on the node-connectivity. In this paper we show that for circular random lattice graphs and mesh graphs algebraic connectivity is a conservative lower bound, and that increases in algebraic connectivity actually correspond to a decrease in node-connectivity. This means that the networks are actually less robust with respect to node-connectivity as the algebraic connectivity increases. However, an increase in algebraic connectivity seems to correlate well with a decrease in the characteristic path length of these networks - which would result in quicker communication through the network. Applications of these results are then discussed for perimeter security.

  3. Robust dynamic mitigation of instabilities

    SciTech Connect

    Kawata, S.; Karino, T.

    2015-04-15

    A dynamic mitigation mechanism for instability growth was proposed and discussed in the paper [S. Kawata, Phys. Plasmas 19, 024503 (2012)]. In the present paper, the robustness of the dynamic instability mitigation mechanism is discussed further. The results presented here show that the mechanism of the dynamic instability mitigation is rather robust against changes in the phase, the amplitude, and the wavelength of the wobbling perturbation applied. Generally, instability would emerge from the perturbation of the physical quantity. Normally, the perturbation phase is unknown so that the instability growth rate is discussed. However, if the perturbation phase is known, the instability growth can be controlled by a superposition of perturbations imposed actively: If the perturbation is induced by, for example, a driving beam axis oscillation or wobbling, the perturbation phase could be controlled, and the instability growth is mitigated by the superposition of the growing perturbations.

  4. A Robust Elliptic Grid Generator

    NASA Astrophysics Data System (ADS)

    Knupp, Patrick M.

    1992-06-01

    A variational principle is proposed that results in a robust elliptic grid generator having many of the strengths of original Winslow or homogeneous Thompson-Thames-Mastin method (hTTM). The new grid generator places grid lines more uniformly over the domain than does hTTM, without loss of orthogonality. Numerically generated examples are given to demonstrate these effects. Grid quality measures are introduced to quantify differences between discrete grids. Both the hTTM and the new grid generator can generate folded grids on certain pathological regions, but overall they are very robust. Grid weighting for solution-adaptive calculations is briefly considered. Generalization of the new method to surface and volume grid generation is straightforward.

  5. Robust modular product family design

    NASA Astrophysics Data System (ADS)

    Jiang, Lan; Allada, Venkat

    2001-10-01

    This paper presents a modified Taguchi methodology to improve the robustness of modular product families against changes in customer requirements. The general research questions posed in this paper are: (1) How to effectively design a product family (PF) that is robust enough to accommodate future customer requirements. (2) How far into the future should designers look to design a robust product family? An example of a simplified vacuum product family is used to illustrate our methodology. In the example, customer requirements are selected as signal factors; future changes of customer requirements are selected as noise factors; an index called quality characteristic (QC) is set to evaluate the product vacuum family; and the module instance matrix (M) is selected as control factor. Initially a relation between the objective function (QC) and the control factor (M) is established, and then the feasible M space is systemically explored using a simplex method to determine the optimum M and the corresponding QC values. Next, various noise levels at different time points are introduced into the system. For each noise level, the optimal values of M and QC are computed and plotted on a QC-chart. The tunable time period of the control factor (the module matrix, M) is computed using the QC-chart. The tunable time period represents the maximum time for which a given control factor can be used to satisfy current and future customer needs. Finally, a robustness index is used to break up the tunable time period into suitable time periods that designers should consider while designing product families.

  6. Robust, optimal subsonic airfoil shapes

    NASA Technical Reports Server (NTRS)

    Rai, Man Mohan (Inventor)

    2008-01-01

    Method system, and product from application of the method, for design of a subsonic airfoil shape, beginning with an arbitrary initial airfoil shape and incorporating one or more constraints on the airfoil geometric parameters and flow characteristics. The resulting design is robust against variations in airfoil dimensions and local airfoil shape introduced in the airfoil manufacturing process. A perturbation procedure provides a class of airfoil shapes, beginning with an initial airfoil shape.

  7. Efficient and Robust Signal Approximations

    DTIC Science & Technology

    2009-05-01

    otherwise. Remark. Permutation matrices are both orthogonal and doubly- stochastic [62]. We will now show how to further simplify the Robust Coding...reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Keywords: signal processing, image compression, independent component analysis , sparse

  8. Robust flight control of rotorcraft

    NASA Astrophysics Data System (ADS)

    Pechner, Adam Daniel

    With recent design improvement in fixed wing aircraft, there has been a considerable interest in the design of robust flight control systems to compensate for the inherent instability necessary to achieve desired performance. Such systems are designed for maximum available retention of stability and performance in the presence of significant vehicle damage or system failure. The rotorcraft industry has shown similar interest in adopting these reconfigurable flight control schemes specifically because of their ability to reject disturbance inputs and provide a significant amount of robustness for all but the most catastrophic of situations. The research summarized herein focuses on the extension of the pseudo-sliding mode control design procedure interpreted in the frequency domain. Application of the technique is employed and simulated on two well known helicopters, a simplified model of a hovering Sikorsky S-61 and the military's Black Hawk UH-60A also produced by Sikorsky. The Sikorsky helicopter model details are readily available and was chosen because it can be limited to pitch and roll motion reducing the number of degrees of freedom and yet contains two degrees of freedom, which is the minimum requirement in proving the validity of the pseudo-sliding control technique. The full order model of a hovering Black Hawk system was included both as a comparison to the S-61 helicopter design system and as a means to demonstrate the scaleability and effectiveness of the control technique on sophisticated systems where design robustness is of critical concern.

  9. Robust Path Planning and Feedback Design Under Stochastic Uncertainty

    NASA Technical Reports Server (NTRS)

    Blackmore, Lars

    2008-01-01

    Autonomous vehicles require optimal path planning algorithms to achieve mission goals while avoiding obstacles and being robust to uncertainties. The uncertainties arise from exogenous disturbances, modeling errors, and sensor noise, which can be characterized via stochastic models. Previous work defined a notion of robustness in a stochastic setting by using the concept of chance constraints. This requires that mission constraint violation can occur with a probability less than a prescribed value.In this paper we describe a novel method for optimal chance constrained path planning with feedback design. The approach optimizes both the reference trajectory to be followed and the feedback controller used to reject uncertainty. Our method extends recent results in constrained control synthesis based on convex optimization to solve control problems with nonconvex constraints. This extension is essential for path planning problems, which inherently have nonconvex obstacle avoidance constraints. Unlike previous approaches to chance constrained path planning, the new approach optimizes the feedback gain as wellas the reference trajectory.The key idea is to couple a fast, nonconvex solver that does not take into account uncertainty, with existing robust approaches that apply only to convex feasible regions. By alternating between robust and nonrobust solutions, the new algorithm guarantees convergence to a global optimum. We apply the new method to an unmanned aircraft and show simulation results that demonstrate the efficacy of the approach.

  10. Robust Path Planning and Feedback Design Under Stochastic Uncertainty

    NASA Technical Reports Server (NTRS)

    Blackmore, Lars

    2008-01-01

    Autonomous vehicles require optimal path planning algorithms to achieve mission goals while avoiding obstacles and being robust to uncertainties. The uncertainties arise from exogenous disturbances, modeling errors, and sensor noise, which can be characterized via stochastic models. Previous work defined a notion of robustness in a stochastic setting by using the concept of chance constraints. This requires that mission constraint violation can occur with a probability less than a prescribed value.In this paper we describe a novel method for optimal chance constrained path planning with feedback design. The approach optimizes both the reference trajectory to be followed and the feedback controller used to reject uncertainty. Our method extends recent results in constrained control synthesis based on convex optimization to solve control problems with nonconvex constraints. This extension is essential for path planning problems, which inherently have nonconvex obstacle avoidance constraints. Unlike previous approaches to chance constrained path planning, the new approach optimizes the feedback gain as wellas the reference trajectory.The key idea is to couple a fast, nonconvex solver that does not take into account uncertainty, with existing robust approaches that apply only to convex feasible regions. By alternating between robust and nonrobust solutions, the new algorithm guarantees convergence to a global optimum. We apply the new method to an unmanned aircraft and show simulation results that demonstrate the efficacy of the approach.

  11. Real-time robust signal space separation for magnetoencephalography.

    PubMed

    Guo, Chenlei; Li, Xin; Taulu, Samu; Wang, Wei; Weber, Douglas J

    2010-08-01

    In this paper, we develop a robust signal space separation (rSSS) algorithm for real-time magnetoencephalography (MEG) data processing. rSSS is based on the spatial signal space separation (SSS) method and it applies robust regression to automatically detect and remove bad MEG channels so that the results of SSS are not distorted. We extend the existing robust regression algorithm via three important new contributions: 1) a low-rank solver that efficiently performs matrix operations; 2) a subspace iteration scheme that selects bad MEG channels using low-order spherical harmonic functions; and 3) a parallel computing implementation that simultaneously runs multiple tasks to further speed up numerical computation. Our experimental results based on both simulation and measurement data demonstrate that rSSS offers superior accuracy over the traditional SSS algorithm, if the MEG data contain significant outliers. Taking advantage of the proposed fast algorithm, rSSS achieves more than 75 x runtime speedup compared to a direct solver of robust regression. Even though rSSS is currently implemented with MATLAB, it already provides sufficient throughput for real-time applications.

  12. Membrane Resonance Enables Stable and Robust Gamma Oscillations

    PubMed Central

    Moca, Vasile V.; Nikolić, Danko; Singer, Wolf; Mureşan, Raul C.

    2014-01-01

    Neuronal mechanisms underlying beta/gamma oscillations (20–80 Hz) are not completely understood. Here, we show that in vivo beta/gamma oscillations in the cat visual cortex sometimes exhibit remarkably stable frequency even when inputs fluctuate dramatically. Enhanced frequency stability is associated with stronger oscillations measured in individual units and larger power in the local field potential. Simulations of neuronal circuitry demonstrate that membrane properties of inhibitory interneurons strongly determine the characteristics of emergent oscillations. Exploration of networks containing either integrator or resonator inhibitory interneurons revealed that: (i) Resonance, as opposed to integration, promotes robust oscillations with large power and stable frequency via a mechanism called RING (Resonance INduced Gamma); resonance favors synchronization by reducing phase delays between interneurons and imposes bounds on oscillation cycle duration; (ii) Stability of frequency and robustness of the oscillation also depend on the relative timing of excitatory and inhibitory volleys within the oscillation cycle; (iii) RING can reproduce characteristics of both Pyramidal INterneuron Gamma (PING) and INterneuron Gamma (ING), transcending such classifications; (iv) In RING, robust gamma oscillations are promoted by slow but are impaired by fast inputs. Results suggest that interneuronal membrane resonance can be an important ingredient for generation of robust gamma oscillations having stable frequency. PMID:23042733

  13. Mitigation of Remedial Action Schemes by Decentralized Robust Governor Control

    SciTech Connect

    Elizondo, Marcelo A.; Marinovici, Laurentiu D.; Lian, Jianming; Kalsi, Karanjit; Du, Pengwei

    2014-04-15

    This paper presents transient stability improvement by a new distributed hierarchical control architecture (DHC). The integration of remedial action schemes (RAS) to the distributed hierarchical control architecture is studied. RAS in power systems are designed to maintain stability and avoid undesired system conditions by rapidly switching equipment and/or changing operating points according to predetermined rules. The acceleration trend relay currently in use in the US western interconnection is an example of RAS that trips generators to maintain transient stability. The link between RAS and DHC is through fast acting robust turbine/governor control that can also improve transient stability. In this paper, the influence of the decentralized robust turbine/governor control on the design of RAS is studied. Benefits of combining these two schemes are increasing power transfer capability and mitigation of RAS generator tripping actions; the later benefit is shown through simulations.

  14. Fast optical pyrometry

    NASA Technical Reports Server (NTRS)

    Cezairliyan, Ared

    1988-01-01

    Design and operation of accurate millisecond and microsecond resolution optical pyrometers developed at the National Bureau of Standards during the last two decades are described. Results of tests are presented and estimates of uncertainties in temperature measurements are given. Calibration methods are discussed and examples of applications of fast pyrometry are given. Ongoing research in developing fast multiwavelength and spatial scanning pyrometers are summarized.

  15. fastKDE

    SciTech Connect

    O'Brien, Travis A.; Kashinath, Karthik

    2015-05-22

    This software implements the fast, self-consistent probability density estimation described by O'Brien et al. (2014, doi: ). It uses a non-uniform fast Fourier transform technique to reduce the computational cost of an objective and self-consistent kernel density estimation method.

  16. Fast and effective?

    PubMed

    Trueland, Jennifer

    2013-12-18

    The 5.2 diet involves two days of fasting each week. It is being promoted as the key to sustained weight loss, as well as wider health benefits, despite the lack of evidence on the long-term effects. Nurses need to support patients who wish to try intermittent fasting.

  17. Fast protein folding kinetics.

    PubMed

    Gelman, Hannah; Gruebele, Martin

    2014-05-01

    Fast-folding proteins have been a major focus of computational and experimental study because they are accessible to both techniques: they are small and fast enough to be reasonably simulated with current computational power, but have dynamics slow enough to be observed with specially developed experimental techniques. This coupled study of fast-folding proteins has provided insight into the mechanisms, which allow some proteins to find their native conformation well <1 ms and has uncovered examples of theoretically predicted phenomena such as downhill folding. The study of fast folders also informs our understanding of even 'slow' folding processes: fast folders are small; relatively simple protein domains and the principles that govern their folding also govern the folding of more complex systems. This review summarizes the major theoretical and experimental techniques used to study fast-folding proteins and provides an overview of the major findings of fast-folding research. Finally, we examine the themes that have emerged from studying fast folders and briefly summarize their application to protein folding in general, as well as some work that is left to do.

  18. Fast protein folding kinetics

    PubMed Central

    Gelman, Hannah; Gruebele, Martin

    2014-01-01

    Fast folding proteins have been a major focus of computational and experimental study because they are accessible to both techniques: they are small and fast enough to be reasonably simulated with current computational power, but have dynamics slow enough to be observed with specially developed experimental techniques. This coupled study of fast folding proteins has provided insight into the mechanisms which allow some proteins to find their native conformation well less than 1 ms and has uncovered examples of theoretically predicted phenomena such as downhill folding. The study of fast folders also informs our understanding of even “slow” folding processes: fast folders are small, relatively simple protein domains and the principles that govern their folding also govern the folding of more complex systems. This review summarizes the major theoretical and experimental techniques used to study fast folding proteins and provides an overview of the major findings of fast folding research. Finally, we examine the themes that have emerged from studying fast folders and briefly summarize their application to protein folding in general as well as some work that is left to do. PMID:24641816

  19. Light field reconstruction robust to signal dependent noise

    NASA Astrophysics Data System (ADS)

    Ren, Kun; Bian, Liheng; Suo, Jinli; Dai, Qionghai

    2014-11-01

    Capturing four dimensional light field data sequentially using a coded aperture camera is an effective approach but suffers from low signal noise ratio. Although multiplexing can help raise the acquisition quality, noise is still a big issue especially for fast acquisition. To address this problem, this paper proposes a noise robust light field reconstruction method. Firstly, scene dependent noise model is studied and incorporated into the light field reconstruction framework. Then, we derive an optimization algorithm for the final reconstruction. We build a prototype by hacking an off-the-shelf camera for data capturing and prove the concept. The effectiveness of this method is validated with experiments on the real captured data.

  20. Robust Soldier Crab Ball Gate

    NASA Astrophysics Data System (ADS)

    Gunji, Yukio-Pegio; Nishiyama, Yuta; Adamatzky, Andrew

    2011-09-01

    Based on the field observation of soldier crabs, we previously proposed a model for a swarm of soldier crabs. Here, we describe the interaction of coherent swarms in the simulation model, which is implemented in a logical gate. Because a swarm is generated by inherent perturbation, a swarm can be generated and maintained under highly perturbed conditions. Thus, the model reveals a robust logical gate rather than stable one. In addition, we show that the logical gate of swarms is also implemented by real soldier crabs (Mictyris guinotae).

  1. Recent Progress toward Robust Photocathodes

    SciTech Connect

    Mulhollan, G. A.; Bierman, J. C.

    2009-08-04

    RF photoinjectors for next generation spin-polarized electron accelerators require photo-cathodes capable of surviving RF gun operation. Free electron laser photoinjectors can benefit from more robust visible light excited photoemitters. A negative electron affinity gallium arsenide activation recipe has been found that diminishes its background gas susceptibility without any loss of near bandgap photoyield. The highest degree of immunity to carbon dioxide exposure was achieved with a combination of cesium and lithium. Activated amorphous silicon photocathodes evince advantageous properties for high current photoinjectors including low cost, substrate flexibility, visible light excitation and greatly reduced gas reactivity compared to gallium arsenide.

  2. Robust Software Architecture for Robots

    NASA Technical Reports Server (NTRS)

    Aghazanian, Hrand; Baumgartner, Eric; Garrett, Michael

    2009-01-01

    Robust Real-Time Reconfigurable Robotics Software Architecture (R4SA) is the name of both a software architecture and software that embodies the architecture. The architecture was conceived in the spirit of current practice in designing modular, hard, realtime aerospace systems. The architecture facilitates the integration of new sensory, motor, and control software modules into the software of a given robotic system. R4SA was developed for initial application aboard exploratory mobile robots on Mars, but is adaptable to terrestrial robotic systems, real-time embedded computing systems in general, and robotic toys.

  3. FAST Construction Progress

    NASA Astrophysics Data System (ADS)

    Nan, R. D.; Zhang, H. Y.; Zhang, Y.; Yang, L.; Cai, W. J.; Liu, N.; Xie, J. T.; Zhang, S. X.

    2016-11-01

    The Five-hundred-meter Aperture Spherical radio Telescope (FAST) is a Chinese mega-science project to build the largest single dish radio telescope in the world. A unique karst depression in Guizhou province has been selected as the site to build an active reflector radio telescope with a diameter of 500 m and three outstanding aspects, which enables FAST to have a large sky coverage and the ability of observing astronomical targets with a high precision. Chinese Academy of Sciences and Guizhou province are in charge of FAST construction. The first light of the telescope was expected on September 25, 2016.

  4. Reusable fast opening switch

    DOEpatents

    Van Devender, J.P.; Emin, D.

    1983-12-21

    A reusable fast opening switch for transferring energy, in the form of a high power pulse, from an electromagnetic storage device such as an inductor into a load. The switch is efficient, compact, fast and reusable. The switch comprises a ferromagnetic semiconductor which undergoes a fast transition between conductive and metallic states at a critical temperature and which undergoes the transition without a phase change in its crystal structure. A semiconductor such as europium rich europhous oxide, which undergoes a conductor to insulator transition when it is joule heated from its conductor state, can be used to form the switch.

  5. Reusable fast opening switch

    DOEpatents

    Van Devender, John P.; Emin, David

    1986-01-01

    A reusable fast opening switch for transferring energy, in the form of a high power pulse, from an electromagnetic storage device such as an inductor into a load. The switch is efficient, compact, fast and reusable. The switch comprises a ferromagnetic semiconductor which undergoes a fast transition between conductive and insulating states at a critical temperature and which undergoes the transition without a phase change in its crystal structure. A semiconductor such as europium rich europhous oxide, which undergoes a conductor to insulator transition when it is joule heated from its conductor state, can be used to form the switch.

  6. Fasting and cognitive function.

    PubMed

    Pollitt, E; Lewis, N L; Garza, C; Shulman, R J

    The effects of short-term fasting (skipping breakfast) on the problem-solving performance of 9 to 11 yr old children were studied under the controlled conditions of a metabolic ward. The behavioral test battery included an assessment of IQ, the Matching Familiar Figure Test and Hagen Central Incidental Test. Glucose and insulin levels were measured in blood. All assessments were made under fasting and non-fasting conditions. Skipping breakfast was found to have adverse effects on the children's late morning problem-solving performance. These findings support observations that the timing and nutrient composition of meals have acute and demonstrable effects on behavior.

  7. Fast Breeder Reactor studies

    SciTech Connect

    Till, C.E.; Chang, Y.I.; Kittel, J.H.; Fauske, H.K.; Lineberry, M.J.; Stevenson, M.G.; Amundson, P.I.; Dance, K.D.

    1980-07-01

    This report is a compilation of Fast Breeder Reactor (FBR) resource documents prepared to provide the technical basis for the US contribution to the International Nuclear Fuel Cycle Evaluation. The eight separate parts deal with the alternative fast breeder reactor fuel cycles in terms of energy demand, resource base, technical potential and current status, safety, proliferation resistance, deployment, and nuclear safeguards. An Annex compares the cost of decommissioning light-water and fast breeder reactors. Separate abstracts are included for each of the parts.

  8. Safety design of prototype fast breeder reactor

    SciTech Connect

    Bhoje, S.B.; Chetal, S.C.; Singh, Om Pal

    2004-07-01

    The basic design and safety design of Prototype Fast Breeder Reactor (PFBR) is presented. Design aspects covered include safety classification, seismic categorization, design basis conditions, design safety limits, core physics, core monitoring, shutdown system, decay heat removal system, protection against sodium leaks and tube leaks in steam generator, plant layout, radiation protection, event analysis, beyond design basis accidents, integrity of primary containment, reactor containment building and design pressure resulting from core disruptive accident. The measures provided in the design represent a robust case of the safety of the reactor. (authors)

  9. Robust Inflation from fibrous strings

    NASA Astrophysics Data System (ADS)

    Burgess, C. P.; Cicoli, M.; de Alwis, S.; Quevedo, F.

    2016-05-01

    Successful inflationary models should (i) describe the data well; (ii) arise generically from sensible UV completions; (iii) be insensitive to detailed fine-tunings of parameters and (iv) make interesting new predictions. We argue that a class of models with these properties is characterized by relatively simple potentials with a constant term and negative exponentials. We here continue earlier work exploring UV completions for these models—including the key (though often ignored) issue of modulus stabilisation—to assess the robustness of their predictions. We show that string models where the inflaton is a fibration modulus seem to be robust due to an effective rescaling symmetry, and fairly generic since most known Calabi-Yau manifolds are fibrations. This class of models is characterized by a generic relation between the tensor-to-scalar ratio r and the spectral index ns of the form r propto (ns-1)2 where the proportionality constant depends on the nature of the effects used to develop the inflationary potential and the topology of the internal space. In particular we find that the largest values of the tensor-to-scalar ratio that can be obtained by generalizing the original set-up are of order r lesssim 0.01. We contrast this general picture with specific popular models, such as the Starobinsky scenario and α-attractors. Finally, we argue the self consistency of large-field inflationary models can strongly constrain non-supersymmetric inflationary mechanisms.

  10. Bayesian robust principal component analysis.

    PubMed

    Ding, Xinghao; He, Lihan; Carin, Lawrence

    2011-12-01

    A hierarchical Bayesian model is considered for decomposing a matrix into low-rank and sparse components, assuming the observed matrix is a superposition of the two. The matrix is assumed noisy, with unknown and possibly non-stationary noise statistics. The Bayesian framework infers an approximate representation for the noise statistics while simultaneously inferring the low-rank and sparse-outlier contributions; the model is robust to a broad range of noise levels, without having to change model hyperparameter settings. In addition, the Bayesian framework allows exploitation of additional structure in the matrix. For example, in video applications each row (or column) corresponds to a video frame, and we introduce a Markov dependency between consecutive rows in the matrix (corresponding to consecutive frames in the video). The properties of this Markov process are also inferred based on the observed matrix, while simultaneously denoising and recovering the low-rank and sparse components. We compare the Bayesian model to a state-of-the-art optimization-based implementation of robust PCA; considering several examples, we demonstrate competitive performance of the proposed model.

  11. Robust Inflation from fibrous strings

    SciTech Connect

    Burgess, C.P.; Cicoli, M.; Alwis, S. de; Quevedo, F.

    2016-05-13

    Successful inflationary models should (i) describe the data well; (ii) arise generically from sensible UV completions; (iii) be insensitive to detailed fine-tunings of parameters and (iv) make interesting new predictions. We argue that a class of models with these properties is characterized by relatively simple potentials with a constant term and negative exponentials. We here continue earlier work exploring UV completions for these models — including the key (though often ignored) issue of modulus stabilisation — to assess the robustness of their predictions. We show that string models where the inflaton is a fibration modulus seem to be robust due to an effective rescaling symmetry, and fairly generic since most known Calabi-Yau manifolds are fibrations. This class of models is characterized by a generic relation between the tensor-to-scalar ratio r and the spectral index n{sub s} of the form r∝(n{sub s}−1){sup 2} where the proportionality constant depends on the nature of the effects used to develop the inflationary potential and the topology of the internal space. In particular we find that the largest values of the tensor-to-scalar ratio that can be obtained by generalizing the original set-up are of order r≲0.01. We contrast this general picture with specific popular models, such as the Starobinsky scenario and α-attractors. Finally, we argue the self consistency of large-field inflationary models can strongly constrain non-supersymmetric inflationary mechanisms.

  12. Robust fusion with reliabilities weights

    NASA Astrophysics Data System (ADS)

    Grandin, Jean-Francois; Marques, Miguel

    2002-03-01

    The reliability is a value of the degree of trust in a given measurement. We analyze and compare: ML (Classical Maximum Likelihood), MLE (Maximum Likelihood weighted by Entropy), MLR (Maximum Likelihood weighted by Reliability), MLRE (Maximum Likelihood weighted by Reliability and Entropy), DS (Credibility Plausibility), DSR (DS weighted by reliabilities). The analysis is based on a model of a dynamical fusion process. It is composed of three sensors, which have each it's own discriminatory capacity, reliability rate, unknown bias and measurement noise. The knowledge of uncertainties is also severely corrupted, in order to analyze the robustness of the different fusion operators. Two sensor models are used: the first type of sensor is able to estimate the probability of each elementary hypothesis (probabilistic masses), the second type of sensor delivers masses on union of elementary hypotheses (DS masses). In the second case probabilistic reasoning leads to sharing the mass abusively between elementary hypotheses. Compared to the classical ML or DS which achieves just 50% of correct classification in some experiments, DSR, MLE, MLR and MLRE reveals very good performances on all experiments (more than 80% of correct classification rate). The experiment was performed with large variations of the reliability coefficients for each sensor (from 0 to 1), and with large variations on the knowledge of these coefficients (from 0 0.8). All four operators reveal good robustness, but the MLR reveals to be uniformly dominant on all the experiments in the Bayesian case and achieves the best mean performance under incomplete a priori information.

  13. The Robustness of Acoustic Analogies

    NASA Technical Reports Server (NTRS)

    Freund, J. B.; Lele, S. K.; Wei, M.

    2004-01-01

    Acoustic analogies for the prediction of flow noise are exact rearrangements of the flow equations N(right arrow q) = 0 into a nominal sound source S(right arrow q) and sound propagation operator L such that L(right arrow q) = S(right arrow q). In practice, the sound source is typically modeled and the propagation operator inverted to make predictions. Since the rearrangement is exact, any sufficiently accurate model of the source will yield the correct sound, so other factors must determine the merits of any particular formulation. Using data from a two-dimensional mixing layer direct numerical simulation (DNS), we evaluate the robustness of two analogy formulations to different errors intentionally introduced into the source. The motivation is that since S can not be perfectly modeled, analogies that are less sensitive to errors in S are preferable. Our assessment is made within the framework of Goldstein's generalized acoustic analogy, in which different choices of a base flow used in constructing L give different sources S and thus different analogies. A uniform base flow yields a Lighthill-like analogy, which we evaluate against a formulation in which the base flow is the actual mean flow of the DNS. The more complex mean flow formulation is found to be significantly more robust to errors in the energetic turbulent fluctuations, but its advantage is less pronounced when errors are made in the smaller scales.

  14. Pneumococcal Disease Fast Facts

    MedlinePlus

    ... Home About Pneumococcal Types of Infection Risk Factors & Transmission Symptoms & Complications Diagnosis & Treatment Prevention Photos Fast Facts Pneumococcal Vaccination For Clinicians Streptococcus pneumoniae Transmission Clinical Features Risk Factors Diagnosis & Management Prevention For ...

  15. FAST joins Breakthrough programme

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2016-11-01

    The 180m Five-hundred-meter Aperture Spherical radio Telescope (FAST) - the world's largest single-aperture radio receiver - has become part of the Breakthrough Listen programme, which launched in July 2015 to look for intelligent life beyond Earth.

  16. Discovery with FAST

    NASA Astrophysics Data System (ADS)

    Wilkinson, P.

    2016-02-01

    FAST offers "transformational" performance well-suited to finding new phenomena - one of which might be polarised spectral transients. But discoveries will only be made if "the system" provides its users with the necessary opportunities. In addition to designing in as much observational flexibility as possible, FAST should be operated with a philosophy which maximises its "human bandwidth". This band includes the astronomers of tomorrow - many of whom not have yet started school or even been born.

  17. FAST Maser Surveys

    NASA Astrophysics Data System (ADS)

    Zhang, J. S.

    2014-09-01

    FAST, the Five-hundred meter Aperture Spherical radio Telescope, will become the largest operating single-dish telescope in the coming years. It has many advantages: much better sensitivity for its largest collecting area; large sky coverage due to its innovative design of the active primary surface; extremely radio quiet from its unique location, etc. In this work, I will highlight the future capabilities of FAST to discover and observe both galactic and extragalactic masers.

  18. Towards direct realisation of the SI unit of sound pressure in the audible hearing range based on optical free-field acoustic particle measurements

    NASA Astrophysics Data System (ADS)

    Koukoulas, Triantafillos; Piper, Ben

    2015-04-01

    Since the introduction of the International System of Units (the SI system) in 1960, weights, measures, standardised approaches, procedures, and protocols have been introduced, adapted, and extensively used. A major international effort and activity concentrate on the definition and traceability of the seven base SI units in terms of fundamental constants, and consequently those units that are derived from the base units. In airborne acoustical metrology and for the audible range of frequencies up to 20 kHz, the SI unit of sound pressure, the pascal, is realised indirectly and without any knowledge or measurement of the sound field. Though the principle of reciprocity was originally formulated by Lord Rayleigh nearly two centuries ago, it was devised in the 1940s and eventually became a calibration standard in the 1960s; however, it can only accommodate a limited number of acoustic sensors of specific types and dimensions. International standards determine the device sensitivity either through coupler or through free-field reciprocity but rely on the continuous availability of specific acoustical artefacts. Here, we show an optical method based on gated photon correlation spectroscopy that can measure sound pressures directly and absolutely in fully anechoic conditions, remotely, and without disturbing the propagating sound field. It neither relies on the availability or performance of any measurement artefact nor makes any assumptions of the device geometry and sound field characteristics. Most importantly, the required units of sound pressure and microphone sensitivity may now be experimentally realised, thus providing direct traceability to SI base units.

  19. Towards direct realisation of the SI unit of sound pressure in the audible hearing range based on optical free-field acoustic particle measurements

    SciTech Connect

    Koukoulas, Triantafillos Piper, Ben

    2015-04-20

    Since the introduction of the International System of Units (the SI system) in 1960, weights, measures, standardised approaches, procedures, and protocols have been introduced, adapted, and extensively used. A major international effort and activity concentrate on the definition and traceability of the seven base SI units in terms of fundamental constants, and consequently those units that are derived from the base units. In airborne acoustical metrology and for the audible range of frequencies up to 20 kHz, the SI unit of sound pressure, the pascal, is realised indirectly and without any knowledge or measurement of the sound field. Though the principle of reciprocity was originally formulated by Lord Rayleigh nearly two centuries ago, it was devised in the 1940s and eventually became a calibration standard in the 1960s; however, it can only accommodate a limited number of acoustic sensors of specific types and dimensions. International standards determine the device sensitivity either through coupler or through free-field reciprocity but rely on the continuous availability of specific acoustical artefacts. Here, we show an optical method based on gated photon correlation spectroscopy that can measure sound pressures directly and absolutely in fully anechoic conditions, remotely, and without disturbing the propagating sound field. It neither relies on the availability or performance of any measurement artefact nor makes any assumptions of the device geometry and sound field characteristics. Most importantly, the required units of sound pressure and microphone sensitivity may now be experimentally realised, thus providing direct traceability to SI base units.

  20. A daily diary investigation of the impact of work stress on exercise intention realisation: can planning overcome the disruptive influence of work?

    PubMed

    Payne, Nicola; Jones, Fiona; Harris, Peter R

    2010-01-01

    Using the theoretical context of the Theory of Planned Behaviour, this study examined whether work has a disruptive influence on people's ability to carry out their daily intentions to exercise, and whether daily planning helps overcome this. A daily questionnaire was completed by 42 employees for 14 days. A brief daily planning intervention was administered to half of the employees. Multilevel modelling was used to analyse the data. The moderating effects of daily perceived behavioural control (PBC), job demands and work-related anxiety and depression on the relationship between intention to exercise and subsequent behaviour were investigated, as well as the impact of the intervention. Intention and PBC predicted exercise. Job demands appeared to disrupt people's ability to carry out their daily exercise intentions. Contrary to expectation, people in the no intervention group were more likely to exercise. Furthermore, on low-demand days they were most successful in realising their exercise intentions (when they intended to exercise for longer), whereas people in the intervention group, on high-demand days were least successful in realising their exercise intentions. The intervention may have operated contrary to expectation by drawing attention to potential failure.

  1. A Robust Feedforward Model of the Olfactory System

    PubMed Central

    Zhang, Yilun; Sharpee, Tatyana O.

    2016-01-01

    Most natural odors have sparse molecular composition. This makes the principles of compressed sensing potentially relevant to the structure of the olfactory code. Yet, the largely feedforward organization of the olfactory system precludes reconstruction using standard compressed sensing algorithms. To resolve this problem, recent theoretical work has shown that signal reconstruction could take place as a result of a low dimensional dynamical system converging to one of its attractor states. However, the dynamical aspects of optimization slowed down odor recognition and were also found to be susceptible to noise. Here we describe a feedforward model of the olfactory system that achieves both strong compression and fast reconstruction that is also robust to noise. A key feature of the proposed model is a specific relationship between how odors are represented at the glomeruli stage, which corresponds to a compression, and the connections from glomeruli to third-order neurons (neurons in the olfactory cortex of vertebrates or Kenyon cells in the mushroom body of insects), which in the model corresponds to reconstruction. We show that should this specific relationship hold true, the reconstruction will be both fast and robust to noise, and in particular to the false activation of glomeruli. The predicted connectivity rate from glomeruli to third-order neurons can be tested experimentally. PMID:27065441

  2. A Robust Feedforward Model of the Olfactory System

    NASA Astrophysics Data System (ADS)

    Zhang, Yilun; Sharpee, Tatyana

    Most natural odors have sparse molecular composition. This makes the principles of compressing sensing potentially relevant to the structure of the olfactory code. Yet, the largely feedforward organization of the olfactory system precludes reconstruction using standard compressed sensing algorithms. To resolve this problem, recent theoretical work has proposed that signal reconstruction could take place as a result of a low dimensional dynamical system converging to one of its attractor states. The dynamical aspects of optimization, however, would slow down odor recognition and were also found to be susceptible to noise. Here we describe a feedforward model of the olfactory system that achieves both strong compression and fast reconstruction that is also robust to noise. A key feature of the proposed model is a specific relationship between how odors are represented at the glomeruli stage, which corresponds to a compression, and the connections from glomeruli to Kenyon cells, which in the model corresponds to reconstruction. We show that provided this specific relationship holds true, the reconstruction will be both fast and robust to noise, and in particular to failure of glomeruli. The predicted connectivity rate from glomeruli to the Kenyon cells can be tested experimentally. This research was supported by James S. McDonnell Foundation, NSF CAREER award IIS-1254123, NSF Ideas Lab Collaborative Research IOS 1556388.

  3. Robust temporal alignment of multimodal cardiac sequences

    NASA Astrophysics Data System (ADS)

    Perissinotto, Andrea; Queirós, Sandro; Morais, Pedro; Baptista, Maria J.; Monaghan, Mark; Rodrigues, Nuno F.; D'hooge, Jan; Vilaça, João. L.; Barbosa, Daniel

    2015-03-01

    Given the dynamic nature of cardiac function, correct temporal alignment of pre-operative models and intraoperative images is crucial for augmented reality in cardiac image-guided interventions. As such, the current study focuses on the development of an image-based strategy for temporal alignment of multimodal cardiac imaging sequences, such as cine Magnetic Resonance Imaging (MRI) or 3D Ultrasound (US). First, we derive a robust, modality-independent signal from the image sequences, estimated by computing the normalized cross-correlation between each frame in the temporal sequence and the end-diastolic frame. This signal is a resembler for the left-ventricle (LV) volume curve over time, whose variation indicates different temporal landmarks of the cardiac cycle. We then perform the temporal alignment of these surrogate signals derived from MRI and US sequences of the same patient through Dynamic Time Warping (DTW), allowing to synchronize both sequences. The proposed framework was evaluated in 98 patients, which have undergone both 3D+t MRI and US scans. The end-systolic frame could be accurately estimated as the minimum of the image-derived surrogate signal, presenting a relative error of 1.6 +/- 1.9% and 4.0 +/- 4.2% for the MRI and US sequences, respectively, thus supporting its association with key temporal instants of the cardiac cycle. The use of DTW reduces the desynchronization of the cardiac events in MRI and US sequences, allowing to temporally align multimodal cardiac imaging sequences. Overall, a generic, fast and accurate method for temporal synchronization of MRI and US sequences of the same patient was introduced. This approach could be straightforwardly used for the correct temporal alignment of pre-operative MRI information and intra-operative US images.

  4. Towards designing robust coupled networks.

    PubMed

    Schneider, Christian M; Yazdani, Nuri; Araújo, Nuno A M; Havlin, Shlomo; Herrmann, Hans J

    2013-01-01

    Natural and technological interdependent systems have been shown to be highly vulnerable due to cascading failures and an abrupt collapse of global connectivity under initial failure. Mitigating the risk by partial disconnection endangers their functionality. Here we propose a systematic strategy of selecting a minimum number of autonomous nodes that guarantee a smooth transition in robustness. Our method which is based on betweenness is tested on various examples including the famous 2003 electrical blackout of Italy. We show that, with this strategy, the necessary number of autonomous nodes can be reduced by a factor of five compared to a random choice. We also find that the transition to abrupt collapse follows tricritical scaling characterized by a set of exponents which is independent on the protection strategy.

  5. Towards designing robust coupled networks

    PubMed Central

    Schneider, Christian M.; Yazdani, Nuri; Araújo, Nuno A. M.; Havlin, Shlomo; Herrmann, Hans J.

    2013-01-01

    Natural and technological interdependent systems have been shown to be highly vulnerable due to cascading failures and an abrupt collapse of global connectivity under initial failure. Mitigating the risk by partial disconnection endangers their functionality. Here we propose a systematic strategy of selecting a minimum number of autonomous nodes that guarantee a smooth transition in robustness. Our method which is based on betweenness is tested on various examples including the famous 2003 electrical blackout of Italy. We show that, with this strategy, the necessary number of autonomous nodes can be reduced by a factor of five compared to a random choice. We also find that the transition to abrupt collapse follows tricritical scaling characterized by a set of exponents which is independent on the protection strategy. PMID:23752705

  6. Towards designing robust coupled networks

    NASA Astrophysics Data System (ADS)

    Schneider, Christian M.; Yazdani, Nuri; Araújo, Nuno A. M.; Havlin, Shlomo; Herrmann, Hans J.

    2013-06-01

    Natural and technological interdependent systems have been shown to be highly vulnerable due to cascading failures and an abrupt collapse of global connectivity under initial failure. Mitigating the risk by partial disconnection endangers their functionality. Here we propose a systematic strategy of selecting a minimum number of autonomous nodes that guarantee a smooth transition in robustness. Our method which is based on betweenness is tested on various examples including the famous 2003 electrical blackout of Italy. We show that, with this strategy, the necessary number of autonomous nodes can be reduced by a factor of five compared to a random choice. We also find that the transition to abrupt collapse follows tricritical scaling characterized by a set of exponents which is independent on the protection strategy.

  7. Robust stochastic mine production scheduling

    NASA Astrophysics Data System (ADS)

    Kumral, Mustafa

    2010-06-01

    The production scheduling of open pit mines aims to determine the extraction sequence of blocks such that the net present value (NPV) of a mining project is maximized under capacity and access constraints. This sequencing has significant effect on the profitability of the mining venture. However, given that the values of coefficients in the optimization procedure are obtained in a medium of sparse data and unknown future events, implementations based on deterministic models may lead to destructive consequences to the company. In this article, a robust stochastic optimization (RSO) approach is used to deal with mine production scheduling in a manner such that the solution is insensitive to changes in input data. The approach seeks a trade off between optimality and feasibility. The model is demonstrated on a case study. The findings showed that the approach can be used in mine production scheduling problems efficiently.

  8. Probabilistic Reasoning for Plan Robustness

    NASA Technical Reports Server (NTRS)

    Schaffer, Steve R.; Clement, Bradley J.; Chien, Steve A.

    2005-01-01

    A planning system must reason about the uncertainty of continuous variables in order to accurately project the possible system state over time. A method is devised for directly reasoning about the uncertainty in continuous activity duration and resource usage for planning problems. By representing random variables as parametric distributions, computing projected system state can be simplified in some cases. Common approximation and novel methods are compared for over-constrained and lightly constrained domains. The system compares a few common approximation methods for an iterative repair planner. Results show improvements in robustness over the conventional non-probabilistic representation by reducing the number of constraint violations witnessed by execution. The improvement is more significant for larger problems and problems with higher resource subscription levels but diminishes as the system is allowed to accept higher risk levels.

  9. Probabilistic Reasoning for Plan Robustness

    NASA Technical Reports Server (NTRS)

    Schaffer, Steve R.; Clement, Bradley J.; Chien, Steve A.

    2005-01-01

    A planning system must reason about the uncertainty of continuous variables in order to accurately project the possible system state over time. A method is devised for directly reasoning about the uncertainty in continuous activity duration and resource usage for planning problems. By representing random variables as parametric distributions, computing projected system state can be simplified in some cases. Common approximation and novel methods are compared for over-constrained and lightly constrained domains. The system compares a few common approximation methods for an iterative repair planner. Results show improvements in robustness over the conventional non-probabilistic representation by reducing the number of constraint violations witnessed by execution. The improvement is more significant for larger problems and problems with higher resource subscription levels but diminishes as the system is allowed to accept higher risk levels.

  10. Robust matching for voice recognition

    NASA Astrophysics Data System (ADS)

    Higgins, Alan; Bahler, L.; Porter, J.; Blais, P.

    1994-10-01

    This paper describes an automated method of comparing a voice sample of an unknown individual with samples from known speakers in order to establish or verify the individual's identity. The method is based on a statistical pattern matching approach that employs a simple training procedure, requires no human intervention (transcription, work or phonetic marketing, etc.), and makes no assumptions regarding the expected form of the statistical distributions of the observations. The content of the speech material (vocabulary, grammar, etc.) is not assumed to be constrained in any way. An algorithm is described which incorporates frame pruning and channel equalization processes designed to achieve robust performance with reasonable computational resources. An experimental implementation demonstrating the feasibility of the concept is described.

  11. Robust characterization of leakage errors

    NASA Astrophysics Data System (ADS)

    Wallman, Joel J.; Barnhill, Marie; Emerson, Joseph

    2016-04-01

    Leakage errors arise when the quantum state leaks out of some subspace of interest, for example, the two-level subspace of a multi-level system defining a computational ‘qubit’, the logical code space of a quantum error-correcting code, or a decoherence-free subspace. Leakage errors pose a distinct challenge to quantum control relative to the more well-studied decoherence errors and can be a limiting factor to achieving fault-tolerant quantum computation. Here we present a scalable and robust randomized benchmarking protocol for quickly estimating the leakage rate due to an arbitrary Markovian noise process on a larger system. We illustrate the reliability of the protocol through numerical simulations.

  12. CONTAINER MATERIALS, FABRICATION AND ROBUSTNESS

    SciTech Connect

    Dunn, K.; Louthan, M.; Rawls, G.; Sindelar, R.; Zapp, P.; Mcclard, J.

    2009-11-10

    The multi-barrier 3013 container used to package plutonium-bearing materials is robust and thereby highly resistant to identified degradation modes that might cause failure. The only viable degradation mechanisms identified by a panel of technical experts were pressurization within and corrosion of the containers. Evaluations of the container materials and the fabrication processes and resulting residual stresses suggest that the multi-layered containers will mitigate the potential for degradation of the outer container and prevent the release of the container contents to the environment. Additionally, the ongoing surveillance programs and laboratory studies should detect any incipient degradation of containers in the 3013 storage inventory before an outer container is compromised.

  13. Robust holographic storage system design.

    PubMed

    Watanabe, Takahiro; Watanabe, Minoru

    2011-11-21

    Demand is increasing daily for large data storage systems that are useful for applications in spacecraft, space satellites, and space robots, which are all exposed to radiation-rich space environment. As candidates for use in space embedded systems, holographic storage systems are promising because they can easily provided the demanded large-storage capability. Particularly, holographic storage systems, which have no rotation mechanism, are demanded because they are virtually maintenance-free. Although a holographic memory itself is an extremely robust device even in a space radiation environment, its associated lasers and drive circuit devices are vulnerable. Such vulnerabilities sometimes engendered severe problems that prevent reading of all contents of the holographic memory, which is a turn-off failure mode of a laser array. This paper therefore presents a proposal for a recovery method for the turn-off failure mode of a laser array on a holographic storage system, and describes results of an experimental demonstration.

  14. Advances in robust flight design

    NASA Technical Reports Server (NTRS)

    Wong, Kelvin K.; Dhand, Sanjeev K.

    1991-01-01

    Current launch vehicle trajectory design philosophies, generally based on maximizing payload capability, result in an expensive and time-consuming iteration in trajectory design for each mission. However, for a launch system that is not performance-driven, a flight design that is robust to variations in missions and provides single-engine-out capability can be highly cost-effective. This philosophy has led to the development of two flight design concepts to reduce recurring costs: standard trajectories and command multiplier steering. Preliminary analyses of these two concepts had proven the feasibility and showed encouraging results in applications to an Advanced Launch System vehicle. Recent progress has demonstrated the effective and efficient integration of the two concepts with minimal payload penalty.

  15. How robust are distributed systems

    NASA Technical Reports Server (NTRS)

    Birman, Kenneth P.

    1989-01-01

    A distributed system is made up of large numbers of components operating asynchronously from one another and hence with imcomplete and inaccurate views of one another's state. Load fluctuations are common as new tasks arrive and active tasks terminate. Jointly, these aspects make it nearly impossible to arrive at detailed predictions for a system's behavior. It is important to the successful use of distributed systems in situations in which humans cannot provide the sorts of predictable realtime responsiveness of a computer, that the system be robust. The technology of today can too easily be affected by worn programs or by seemingly trivial mechanisms that, for example, can trigger stock market disasters. Inventors of a technology have an obligation to overcome flaws that can exact a human cost. A set of principles for guiding solutions to distributed computing problems is presented.

  16. The structure of robust observers

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, S. P.

    1975-01-01

    Conventional observers for linear time-invariant systems are shown to be structurally inadequate from a sensitivity standpoint. It is proved that if a linear dynamic system is to provide observer action despite arbitrary small perturbations in a specified subset of its parameters, it must: (1) be a closed loop system, be driven by the observer error, (2) possess redundancy, the observer must be generating, implicitly or explicitly, at least one linear combination of states that is already contained in the measurements, and (3) contain a perturbation-free model of the portion of the system observable from the external input to the observer. The procedure for design of robust observers possessing the above structural features is established and discussed.

  17. Adaptive fast interface tracking methods

    NASA Astrophysics Data System (ADS)

    Popovic, Jelena; Runborg, Olof

    2017-05-01

    In this paper, we present a fast time adaptive numerical method for interface tracking. The method uses an explicit multiresolution description of the interface, which is represented by wavelet vectors that correspond to the details of the interface on different scale levels. The complexity of standard numerical methods for interface tracking, where the interface is described by N marker points, is O (N / Δt), when a time step Δt is used. The methods that we propose in this paper have O (TOL - 1 / p log ⁡ N + Nlog ⁡ N) computational cost, at least for uniformly smooth problems, where TOL is some given tolerance and p is the order of the time stepping method that is used for time advection of the interface. The adaptive method is robust in the sense that it can handle problems with both smooth and piecewise smooth interfaces (e.g. interfaces with corners) while keeping a low computational cost. We show numerical examples that verify these properties.

  18. Fast evaluation of polarizable forces.

    PubMed

    Wang, Wei; Skeel, Robert D

    2005-10-22

    Polarizability is considered to be the single most significant development in the next generation of force fields for biomolecular simulations. However, the self-consistent computation of induced atomic dipoles in a polarizable force field is expensive due to the cost of solving a large dense linear system at each step of a simulation. This article introduces methods that reduce the cost of computing the electrostatic energy and force of a polarizable model from about 7.5 times the cost of computing those of a nonpolarizable model to less than twice the cost. This is probably sufficient for the routine use of polarizable forces in biomolecular simulations. The reduction in computing time is achieved by an efficient implementation of the particle-mesh Ewald method, an accurate and robust predictor based on least-squares fitting, and non-stationary iterative methods whose fast convergence is accelerated by a simple preconditioner. Furthermore, with these methods, the self-consistent approach with a larger timestep is shown to be faster than the extended Lagrangian approach. The use of dipole moments from previous timesteps to calculate an accurate initial guess for iterative methods leads to an energy drift, which can be made acceptably small. The use of a zero initial guess does not lead to perceptible energy drift if a reasonably strict convergence criterion for the iteration is imposed.

  19. Mechanisms of mutational robustness in transcriptional regulation

    PubMed Central

    Payne, Joshua L.; Wagner, Andreas

    2015-01-01

    Robustness is the invariance of a phenotype in the face of environmental or genetic change. The phenotypes produced by transcriptional regulatory circuits are gene expression patterns that are to some extent robust to mutations. Here we review several causes of this robustness. They include robustness of individual transcription factor binding sites, homotypic clusters of such sites, redundant enhancers, transcription factors, redundant transcription factors, and the wiring of transcriptional regulatory circuits. Such robustness can either be an adaptation by itself, a byproduct of other adaptations, or the result of biophysical principles and non-adaptive forces of genome evolution. The potential consequences of such robustness include complex regulatory network topologies that arise through neutral evolution, as well as cryptic variation, i.e., genotypic divergence without phenotypic divergence. On the longest evolutionary timescales, the robustness of transcriptional regulation has helped shape life as we know it, by facilitating evolutionary innovations that helped organisms such as flowering plants and vertebrates diversify. PMID:26579194

  20. COST Action TU1208 - Working Group 1 - Design and realisation of Ground Penetrating Radar equipment for civil engineering applications

    NASA Astrophysics Data System (ADS)

    Pajewski, Lara; Benedetto, Andrea; D'Amico, Sebastiano; Ferrara, Vincenzo; Frezza, Fabrizio; Persico, Raffaele; Tosti, Fabio

    2017-04-01

    provided by the Italian company IDS Ingegneria dei Sistemi; in cooperation with the Spanish company Euroconsult, an instrumented lorry equipped with a curviameter was used in the same road sections. Curviameter and GPR results were compared, with very good agreement. 3. A reconfigurable stepped-frequency GPR prototype was improved and widely tested. The original version of this prototype was designed and realised in Italy, in 2008. In June 2014, with the support of the Action TU1208 (and in particular by exploiting the Short Term Scientific Mission (STSM) networking tool), this prototype was brought to Norway: tests were carried out in laboratory, on roads and archaelogical sites; results were compared with those obtained by using a commercial system manufactured by the Norwegian manufacturer 3d-radar. As a result of this work, it was possible to understand how to improve the Italian prototype. Changes to the hardware were implemented in cooperation with the company Florence Engineering. In the improved version of the prototype, a more advanced technique is used for the reconfiguration of the integration times. In July 2015, by exploiting again the STSM tool, the prototype was brought to Malta: tests were carried out in buildings, churches, archaeological and geological sites; results were compared with those obtained by using a commercial pulsed system manufactured by IDS Ingegneria dei Sistemi. It is worth pointing out that this was the first time GPR measurements were carried out in Malta, where no GPR systems are available. Finally, in January 2016 the improved prototype was again brought to Malta in order to be used during the experimental sessions of a TU1208 Training School. This is an excellent example of a successful scientific activity where STSM and TS COST networking tools were effectively exploited, the cooperation with industry was of central importance, and a less research-intensive Country was deliberately chosen, to test the improved system. 4. A cheap

  1. Dynamic optimization of bioprocesses: efficient and robust numerical strategies.

    PubMed

    Banga, Julio R; Balsa-Canto, Eva; Moles, Carmen G; Alonso, Antonio A

    2005-06-29

    The dynamic optimization (open loop optimal control) of non-linear bioprocesses is considered in this contribution. These processes can be described by sets of non-linear differential and algebraic equations (DAEs), usually subject to constraints in the state and control variables. A review of the available solution techniques for this class of problems is presented, highlighting the numerical difficulties arising from the non-linear, constrained and often discontinuous nature of these systems. In order to surmount these difficulties, we present several alternative stochastic and hybrid techniques based on the control vector parameterization (CVP) approach. The CVP approach is a direct method which transforms the original problem into a non-linear programming (NLP) problem, which must be solved by a suitable (efficient and robust) solver. In particular, a hybrid technique uses a first global optimization phase followed by a fast second phase based on a local deterministic method, so it can handle the nonconvexity of many of these NLPs. The efficiency and robustness of these techniques is illustrated by solving several challenging case studies regarding the optimal control of fed-batch bioreactors and other bioprocesses. In order to fairly evaluate their advantages, a careful and critical comparison with several other direct approaches is provided. The results indicate that the two-phase hybrid approach presents the best compromise between robustness and efficiency.

  2. Robust Optimal Adaptive Control Method with Large Adaptive Gain

    NASA Technical Reports Server (NTRS)

    Nguyen, Nhan T.

    2009-01-01

    In the presence of large uncertainties, a control system needs to be able to adapt rapidly to regain performance. Fast adaptation is referred to the implementation of adaptive control with a large adaptive gain to reduce the tracking error rapidly. However, a large adaptive gain can lead to high-frequency oscillations which can adversely affect robustness of an adaptive control law. A new adaptive control modification is presented that can achieve robust adaptation with a large adaptive gain without incurring high-frequency oscillations as with the standard model-reference adaptive control. The modification is based on the minimization of the Y2 norm of the tracking error, which is formulated as an optimal control problem. The optimality condition is used to derive the modification using the gradient method. The optimal control modification results in a stable adaptation and allows a large adaptive gain to be used for better tracking while providing sufficient stability robustness. Simulations were conducted for a damaged generic transport aircraft with both standard adaptive control and the adaptive optimal control modification technique. The results demonstrate the effectiveness of the proposed modification in tracking a reference model while maintaining a sufficient time delay margin.

  3. Fast wave current drive

    NASA Astrophysics Data System (ADS)

    Goree, J.; Ono, M.; Colestock, P.; Horton, R.; McNeill, D.; Park, H.

    1985-07-01

    Experiments on the fast wave in the range of high ion cyclotron harmonics in the ACT-1 device show that current drive is possible with the fast wave just as it is for the lower hybrid wave, except that it is suitable for higher plasma densities. A 140° loop antenna launched the high ion cyclotron harmonic fast wave [ω/Ω=O(10)] into a He+ plasma with ne≂4×1012 cm-3 and B=4.5 kG. Probe and magnetic loop diagnostics and FIR laser scattering confirmed the presence of the fast wave, and the Rogowski loop indicated that the circulating plasma current increased by up to 40A with 1 kW of coupled power, which is comparable to lower hybrid current drive in the same device with the same unidirectional fast electron beam used as the target for the rf. A phased antenna array would be used for FWCD in a tokamak without the E-beam.

  4. Fast food prices, obesity, and the minimum wage.

    PubMed

    Cotti, Chad; Tefft, Nathan

    2013-03-01

    Recent proposals argue that a fast food tax may be an effective policy lever for reducing population weight. Although there is growing evidence for a negative association between fast food prices and weight among adolescents, less is known about adults. That any measured relationship to date is causal is unclear because there has been no attempt to separate variation in prices on the demand side from that on the supply side. We argue that the minimum wage is an exogenous source of variation in fast food prices, conditional on income and employment. In two-stage least-squares analyses, we find little evidence that fast food price changes affect adult BMI or obesity prevalence. Results are robust to including controls for area and time fixed effects, area time trends, demographic characteristics, substitute prices, numbers of establishments and employment in related industries, and other potentially related factors. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. Valiant load-balanced robust routing under hose model for WDM mesh networks

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaoning; Li, Lemin; Wang, Sheng

    2006-09-01

    In this paper, we propose Valiant Load-Balanced robust routing scheme for WDM mesh networks under the model of polyhedral uncertainty (i.e., hose model), and the proposed routing scheme is implemented with traffic grooming approach. Our Objective is to maximize the hose model throughput. A mathematic formulation of Valiant Load-Balanced robust routing is presented and three fast heuristic algorithms are also proposed. When implementing Valiant Load-Balanced robust routing scheme to WDM mesh networks, a novel traffic-grooming algorithm called MHF (minimizing hop first) is proposed. We compare the three heuristic algorithms with the VPN tree under the hose model. Finally we demonstrate in the simulation results that MHF with Valiant Load-Balanced robust routing scheme outperforms the traditional traffic-grooming algorithm in terms of the throughput for the uniform/non-uniform traffic matrix under the hose model.

  6. A Fast Hermite Transform.

    PubMed

    Leibon, Gregory; Rockmore, Daniel N; Park, Wooram; Taintor, Robert; Chirikjian, Gregory S

    2008-12-17

    We present algorithms for fast and stable approximation of the Hermite transform of a compactly supported function on the real line, attainable via an application of a fast algebraic algorithm for computing sums associated with a three-term relation. Trade-offs between approximation in bandlimit (in the Hermite sense) and size of the support region are addressed. Numerical experiments are presented that show the feasibility and utility of our approach. Generalizations to any family of orthogonal polynomials are outlined. Applications to various problems in tomographic reconstruction, including the determination of protein structure, are discussed.

  7. Fast Overcurrent Tripping Circuit

    NASA Technical Reports Server (NTRS)

    Sullender, Craig C.; Davies, Bryan L.; Osborn, Stephen H.

    1993-01-01

    Fast overcurrent tripping circuit designed for incorporation into power metal oxide/semiconductor field-effect transistor (MOSFET) switching circuit. Serves as fast electronic circuit breaker by sensing voltage across MOSFET's during conduction and switching MOSFET's off within 1 microsecond after voltage exceeds reference value corresponding to tripping current. Acts more quickly than Hall-effect current sensor and, in comparison with shunt current-measuring circuits, smaller and consumes less power. Also ignores initial transient overcurrents during first 5 microseconds of switching cycle.

  8. Robust control of flexible space vehicles with minimum structural excitation: On-off pulse control of flexible space vehicles

    NASA Technical Reports Server (NTRS)

    Wie, Bong; Liu, Qiang

    1992-01-01

    Both feedback and feedforward control approaches for uncertain dynamical systems (in particular, with uncertainty in structural mode frequency) are investigated. The control objective is to achieve a fast settling time (high performance) and robustness (insensitivity) to plant uncertainty. Preshaping of an ideal, time optimal control input using a tapped-delay filter is shown to provide a fast settling time with robust performance. A robust, non-minimum-phase feedback controller is synthesized with particular emphasis on its proper implementation for a non-zero set-point control problem. It is shown that a properly designed, feedback controller performs well, as compared with a time optimal open loop controller with special preshaping for performance robustness. Also included are two separate papers by the same authors on this subject.

  9. Robustness, canalyzing functions and systems design.

    PubMed

    Rauh, Johannes; Ay, Nihat

    2014-06-01

    We study a notion of knockout robustness of a stochastic map (Markov kernel) that describes a system of several input random variables and one output random variable. Robustness requires that the behaviour of the system does not change if one or several of the input variables are knocked out. Gibbs potentials are used to give a mechanistic description of the behaviour of the system after knockouts. Robustness imposes structural constraints on these potentials. We show that robust systems can be described in terms of suitable interaction families of Gibbs potentials, which allows us to address the problem of systems design. Robustness is also characterized by conditional independence constraints on the joint distribution of input and output. The set of all probability distributions corresponding to robust systems can be decomposed into a finite union of components, and we find parametrizations of the components.

  10. Selection for robustness in mutagenized RNA viruses.

    PubMed

    Sanjuán, Rafael; Cuevas, José M; Furió, Victoria; Holmes, Edward C; Moya, Andrés

    2007-06-01

    Mutational robustness is defined as the constancy of a phenotype in the face of deleterious mutations. Whether robustness can be directly favored by natural selection remains controversial. Theory and in silico experiments predict that, at high mutation rates, slow-replicating genotypes can potentially outcompete faster counterparts if they benefit from a higher robustness. Here, we experimentally validate this hypothesis, dubbed the "survival of the flattest," using two populations of the vesicular stomatitis RNA virus. Characterization of fitness distributions and genetic variability indicated that one population showed a higher replication rate, whereas the other was more robust to mutation. The faster replicator outgrew its robust counterpart in standard competition assays, but the outcome was reversed in the presence of chemical mutagens. These results show that selection can directly favor mutational robustness and reveal a novel viral resistance mechanism against treatment by lethal mutagenesis.

  11. A network property necessary for concentration robustness

    NASA Astrophysics Data System (ADS)

    Eloundou-Mbebi, Jeanne M. O.; Küken, Anika; Omranian, Nooshin; Kleessen, Sabrina; Neigenfind, Jost; Basler, Georg; Nikoloski, Zoran

    2016-10-01

    Maintenance of functionality of complex cellular networks and entire organisms exposed to environmental perturbations often depends on concentration robustness of the underlying components. Yet, the reasons and consequences of concentration robustness in large-scale cellular networks remain largely unknown. Here, we derive a necessary condition for concentration robustness based only on the structure of networks endowed with mass action kinetics. The structural condition can be used to design targeted experiments to study concentration robustness. We show that metabolites satisfying the necessary condition are present in metabolic networks from diverse species, suggesting prevalence of this property across kingdoms of life. We also demonstrate that our predictions about concentration robustness of energy-related metabolites are in line with experimental evidence from Escherichia coli. The necessary condition is applicable to mass action biological systems of arbitrary size, and will enable understanding the implications of concentration robustness in genetic engineering strategies and medical applications.

  12. A network property necessary for concentration robustness

    PubMed Central

    Eloundou-Mbebi, Jeanne M. O.; Küken, Anika; Omranian, Nooshin; Kleessen, Sabrina; Neigenfind, Jost; Basler, Georg; Nikoloski, Zoran

    2016-01-01

    Maintenance of functionality of complex cellular networks and entire organisms exposed to environmental perturbations often depends on concentration robustness of the underlying components. Yet, the reasons and consequences of concentration robustness in large-scale cellular networks remain largely unknown. Here, we derive a necessary condition for concentration robustness based only on the structure of networks endowed with mass action kinetics. The structural condition can be used to design targeted experiments to study concentration robustness. We show that metabolites satisfying the necessary condition are present in metabolic networks from diverse species, suggesting prevalence of this property across kingdoms of life. We also demonstrate that our predictions about concentration robustness of energy-related metabolites are in line with experimental evidence from Escherichia coli. The necessary condition is applicable to mass action biological systems of arbitrary size, and will enable understanding the implications of concentration robustness in genetic engineering strategies and medical applications. PMID:27759015

  13. Efficient robust conditional random fields.

    PubMed

    Song, Dongjin; Liu, Wei; Zhou, Tianyi; Tao, Dacheng; Meyer, David A

    2015-10-01

    Conditional random fields (CRFs) are a flexible yet powerful probabilistic approach and have shown advantages for popular applications in various areas, including text analysis, bioinformatics, and computer vision. Traditional CRF models, however, are incapable of selecting relevant features as well as suppressing noise from noisy original features. Moreover, conventional optimization methods often converge slowly in solving the training procedure of CRFs, and will degrade significantly for tasks with a large number of samples and features. In this paper, we propose robust CRFs (RCRFs) to simultaneously select relevant features. An optimal gradient method (OGM) is further designed to train RCRFs efficiently. Specifically, the proposed RCRFs employ the l1 norm of the model parameters to regularize the objective used by traditional CRFs, therefore enabling discovery of the relevant unary features and pairwise features of CRFs. In each iteration of OGM, the gradient direction is determined jointly by the current gradient together with the historical gradients, and the Lipschitz constant is leveraged to specify the proper step size. We show that an OGM can tackle the RCRF model training very efficiently, achieving the optimal convergence rate [Formula: see text] (where k is the number of iterations). This convergence rate is theoretically superior to the convergence rate O(1/k) of previous first-order optimization methods. Extensive experiments performed on three practical image segmentation tasks demonstrate the efficacy of OGM in training our proposed RCRFs.

  14. Robust boosting via convex optimization

    NASA Astrophysics Data System (ADS)

    Rätsch, Gunnar

    2001-12-01

    In this work we consider statistical learning problems. A learning machine aims to extract information from a set of training examples such that it is able to predict the associated label on unseen examples. We consider the case where the resulting classification or regression rule is a combination of simple rules - also called base hypotheses. The so-called boosting algorithms iteratively find a weighted linear combination of base hypotheses that predict well on unseen data. We address the following issues: o The statistical learning theory framework for analyzing boosting methods. We study learning theoretic guarantees on the prediction performance on unseen examples. Recently, large margin classification techniques emerged as a practical result of the theory of generalization, in particular Boosting and Support Vector Machines. A large margin implies a good generalization performance. Hence, we analyze how large the margins in boosting are and find an improved algorithm that is able to generate the maximum margin solution. o How can boosting methods be related to mathematical optimization techniques? To analyze the properties of the resulting classification or regression rule, it is of high importance to understand whether and under which conditions boosting converges. We show that boosting can be used to solve large scale constrained optimization problems, whose solutions are well characterizable. To show this, we relate boosting methods to methods known from mathematical optimization, and derive convergence guarantees for a quite general family of boosting algorithms. o How to make Boosting noise robust? One of the problems of current boosting techniques is that they are sensitive to noise in the training sample. In order to make boosting robust, we transfer the soft margin idea from support vector learning to boosting. We develop theoretically motivated regularized algorithms that exhibit a high noise robustness. o How to adapt boosting to regression problems

  15. A Robust, Microwave Rain Gauge

    NASA Astrophysics Data System (ADS)

    Mansheim, T. J.; Niemeier, J. J.; Kruger, A.

    2008-12-01

    Researchers at The University of Iowa have developed an all-electronic rain gauge that uses microwave sensors operating at either 10 GHz or 23 GHz, and measures the Doppler shift caused by falling raindrops. It is straightforward to interface these sensors with conventional data loggers, or integrate them into a wireless sensor network. A disadvantage of these microwave rain gauges is that they consume significant power when they are operating. However, this may be partially negated by using data loggers' or sensors networks' sleep-wake-sleep mechanism. Advantages of the microwave rain gauges are that one can make them very robust, they cannot clog, they don't have mechanical parts that wear out, and they don't have to be perfectly level. Prototype microwave rain gauges were collocated with tipping-bucket rain gauges, and data were collected for two seasons. At higher rain rates, microwave rain gauge measurements compare well with tipping-bucket measurements. At lower rain rates, the microwave rain gauges provide more detailed information than tipping buckets, which quantize measurement typically in 1 tip per 0.01 inch, or 1 tip per mm of rainfall.

  16. Designing for Reliability and Robustness

    NASA Technical Reports Server (NTRS)

    Svetlik, Randall G.; Moore, Cherice; Williams, Antony

    2017-01-01

    Long duration spaceflight has a negative effect on the human body, and exercise countermeasures are used on-board the International Space Station (ISS) to minimize bone and muscle loss, combatting these effects. Given the importance of these hardware systems to the health of the crew, this equipment must continue to be readily available. Designing spaceflight exercise hardware to meet high reliability and availability standards has proven to be challenging throughout the time the crewmembers have been living on ISS beginning in 2000. Furthermore, restoring operational capability after a failure is clearly time-critical, but can be problematic given the challenges of troubleshooting the problem from 220 miles away. Several best-practices have been leveraged in seeking to maximize availability of these exercise systems, including designing for robustness, implementing diagnostic instrumentation, relying on user feedback, and providing ample maintenance and sparing. These factors have enhanced the reliability of hardware systems, and therefore have contributed to keeping the crewmembers healthy upon return to Earth. This paper will review the failure history for three spaceflight exercise countermeasure systems identifying lessons learned that can help improve future systems. Specifically, the Treadmill with Vibration Isolation and Stabilization System (TVIS), Cycle Ergometer with Vibration Isolation and Stabilization System (CEVIS), and the Advanced Resistive Exercise Device (ARED) will be reviewed, analyzed, and conclusions identified so as to provide guidance for improving future exercise hardware designs. These lessons learned, paired with thorough testing, offer a path towards reduced system down-time.

  17. Nanotechnology Based Environmentally Robust Primers

    SciTech Connect

    Barbee, T W Jr; Gash, A E; Satcher, J H Jr; Simpson, R L

    2003-03-18

    An initiator device structure consisting of an energetic metallic nano-laminate foil coated with a sol-gel derived energetic nano-composite has been demonstrated. The device structure consists of a precision sputter deposition synthesized nano-laminate energetic foil of non-toxic and non-hazardous metals along with a ceramic-based energetic sol-gel produced coating made up of non-toxic and non-hazardous components such as ferric oxide and aluminum metal. Both the nano-laminate and sol-gel technologies are versatile commercially viable processes that allow the ''engineering'' of properties such as mechanical sensitivity and energy output. The nano-laminate serves as the mechanically sensitive precision igniter and the energetic sol-gel functions as a low-cost, non-toxic, non-hazardous booster in the ignition train. In contrast to other energetic nanotechnologies these materials can now be safely manufactured at application required levels, are structurally robust, have reproducible and engineerable properties, and have excellent aging characteristics.

  18. Robust growth of Escherichia coli.

    PubMed

    Wang, Ping; Robert, Lydia; Pelletier, James; Dang, Wei Lien; Taddei, Francois; Wright, Andrew; Jun, Suckjoon

    2010-06-22

    The quantitative study of the cell growth has led to many fundamental insights in our understanding of a wide range of subjects, from the cell cycle to senescence. Of particular importance is the growth rate, whose constancy represents a physiological steady state of an organism. Recent studies, however, suggest that the rate of elongation during exponential growth of bacterial cells decreases cumulatively with replicative age for both asymmetrically and symmetrically dividing organisms, implying that a "steady-state" population consists of individual cells that are never in a steady state of growth. To resolve this seeming paradoxical observation, we studied the long-term growth and division patterns of Escherichia coli cells by employing a microfluidic device designed to follow steady-state growth and division of a large number of cells at a defined reproductive age. Our analysis of approximately 10(5) individual cells reveals a remarkable stability of growth whereby the mother cell inherits the same pole for hundreds of generations. We further show that death of E. coli is not purely stochastic but is the result of accumulating damages. We conclude that E. coli, unlike all other aging model systems studied to date, has a robust mechanism of growth that is decoupled from cell death.

  19. Robust distortion correction of endoscope

    NASA Astrophysics Data System (ADS)

    Li, Wenjing; Nie, Sixiang; Soto-Thompson, Marcelo; Chen, Chao-I.; A-Rahim, Yousif I.

    2008-03-01

    Endoscopic images suffer from a fundamental spatial distortion due to the wide angle design of the endoscope lens. This barrel-type distortion is an obstacle for subsequent Computer Aided Diagnosis (CAD) algorithms and should be corrected. Various methods and research models for the barrel-type distortion correction have been proposed and studied. For industrial applications, a stable, robust method with high accuracy is required to calibrate the different types of endoscopes in an easy of use way. The correction area shall be large enough to cover all the regions that the physicians need to see. In this paper, we present our endoscope distortion correction procedure which includes data acquisition, distortion center estimation, distortion coefficients calculation, and look-up table (LUT) generation. We investigate different polynomial models used for modeling the distortion and propose a new one which provides correction results with better visual quality. The method has been verified with four types of colonoscopes. The correction procedure is currently being applied on human subject data and the coefficients are being utilized in a subsequent 3D reconstruction project of colon.

  20. Towards Robust Image Matching Algorithms

    NASA Astrophysics Data System (ADS)

    Parsons, Timothy J.

    1984-12-01

    The rapid advance in digital electronics during recent years has enabled the real-time hardware implementation of many basic image processing techniques and these methods are finding increasing use in both commercial and military applications where a superiority to existing systems can be demonstrated. The potential superiority of an entirely passive, automatic image processing based navigation system over the less accurate and active navigation systems based on radar, for example "TERCOM", is evident. By placing a sensor on board an aircraft or missile together with the appropriate processing power and enough memory to store a reference image or a map of the planned route, large scale features extracted from the scene available to the sensor can be compared with the same feature stored in memory. The difference between the aircraft's actual position and its desired position can then be evaluated and the appropriate navigational correction undertaken. This paper summaries work carried out at British Aerospace Hatfield to investigate various classes of algorithms and solutions which would render a robust image matching system viable for such an automatic system flying at low level with a thermal I.R. sensor.

  1. Robust Face Sketch Style Synthesis.

    PubMed

    Shengchuan Zhang; Xinbo Gao; Nannan Wang; Jie Li

    2016-01-01

    Heterogeneous image conversion is a critical issue in many computer vision tasks, among which example-based face sketch style synthesis provides a convenient way to make artistic effects for photos. However, existing face sketch style synthesis methods generate stylistic sketches depending on many photo-sketch pairs. This requirement limits the generalization ability of these methods to produce arbitrarily stylistic sketches. To handle such a drawback, we propose a robust face sketch style synthesis method, which can convert photos to arbitrarily stylistic sketches based on only one corresponding template sketch. In the proposed method, a sparse representation-based greedy search strategy is first applied to estimate an initial sketch. Then, multi-scale features and Euclidean distance are employed to select candidate image patches from the initial estimated sketch and the template sketch. In order to further refine the obtained candidate image patches, a multi-feature-based optimization model is introduced. Finally, by assembling the refined candidate image patches, the completed face sketch is obtained. To further enhance the quality of synthesized sketches, a cascaded regression strategy is adopted. Compared with the state-of-the-art face sketch synthesis methods, experimental results on several commonly used face sketch databases and celebrity photos demonstrate the effectiveness of the proposed method.

  2. Close to community health providers post 2015: Realising their role in responsive health systems and addressing gendered social determinants of health

    PubMed Central

    2015-01-01

    Universal health coverage is gaining momentum and is likely to form a core part of the post Millennium Development Goal (MDG) agenda and be linked to social determinants of health, including gender; Close to community health providers are arguably key players in meeting the goal of universal health coverage through extending and delivering health services to poor and marginalised groups; Close to community health providers are embedded in communities and may therefore be strategically placed to understand intra household gender and power dynamics and how social determinants shape health and well-being. However, the opportunities to develop critical awareness and to translate this knowledge into health system and multi-sectoral action are poorly understood; Enabling close to community health providers to realise their potential requires health systems support and human resource management at multiple levels. PMID:28281706

  3. Robust satisficing and the probability of survival

    NASA Astrophysics Data System (ADS)

    Ben-Haim, Yakov

    2014-01-01

    Concepts of robustness are sometimes employed when decisions under uncertainty are made without probabilistic information. We present a theorem that establishes necessary and sufficient conditions for non-probabilistic robustness to be equivalent to the probability of satisfying the specified outcome requirements. When this holds, probability is enhanced (or maximised) by enhancing (or maximising) robustness. Two further theorems establish important special cases. These theorems have implications for success or survival under uncertainty. Applications to foraging and finance are discussed.

  4. Robustness enhancement of neurocontroller and state estimator

    NASA Technical Reports Server (NTRS)

    Troudet, Terry

    1993-01-01

    The feasibility of enhancing neurocontrol robustness, through training of the neurocontroller and state estimator in the presence of system uncertainties, is investigated on the example of a multivariable aircraft control problem. The performance and robustness of the newly trained neurocontroller are compared to those for an existing neurocontrol design scheme. The newly designed dynamic neurocontroller exhibits a better trade-off between phase and gain stability margins, and it is significantly more robust to degradations of the plant dynamics.

  5. Integral Fast Reactor concept

    SciTech Connect

    Till, C.E.; Chang, Y.I.

    1986-01-01

    The Integral Fast Reactor (IFR) is an innovative LMR concept, being developed at Argonne National Laboratory, that fully exploits the inherent properties of liquid metal cooling and metallic fuel to achieve breakthroughs in economics and inherent safety. This paper describes key features and potential advantages of the IFR concept, technology development status, fuel cycle economics potential, and future development path.

  6. The Integral Fast Reactor

    SciTech Connect

    Till, C.E.; Chang, Y.I. ); Lineberry, M.J. )

    1990-01-01

    Argonne National Laboratory, since 1984, has been developing the Integral Fast Reactor (IFR). This paper will describe the way in which this new reactor concept came about; the technical, public acceptance, and environmental issues that are addressed by the IFR; the technical progress that has been made; and our expectations for this program in the near term. 5 refs., 3 figs.

  7. Fast ForWord.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO.

    This paper provides an overview of Fast ForWord, a CD-ROM and Internet-based training program for children (pre-K to grade 8) with language and reading problems that helps children rapidly build oral language comprehension and other critical skills necessary for learning to read or becoming a better reader. With the help of computers, speech…

  8. Robust Fixed-Structure Controller Synthesis

    NASA Technical Reports Server (NTRS)

    Corrado, Joseph R.; Haddad, Wassim M.; Gupta, Kajal (Technical Monitor)

    2000-01-01

    The ability to develop an integrated control system design methodology for robust high performance controllers satisfying multiple design criteria and real world hardware constraints constitutes a challenging task. The increasingly stringent performance specifications required for controlling such systems necessitates a trade-off between controller complexity and robustness. The principle challenge of the minimal complexity robust control design is to arrive at a tractable control design formulation in spite of the extreme complexity of such systems. Hence, design of minimal complexitY robust controllers for systems in the face of modeling errors has been a major preoccupation of system and control theorists and practitioners for the past several decades.

  9. Biologically inspired robust onset detection

    NASA Astrophysics Data System (ADS)

    Smith, Leslie S.

    2003-04-01

    Onsets are rapid increases in signal strength. The common onset time in different frequency bands provides an important cue for dynamically grouping sound energy, and hence for sound streaming. Onsets are important for segmenting sounds [Smith, J. New Music Res. 23, 11-23 (1994)] and for determining where to measure IIDs and ITDs for the sound direction finding [Smith, J. Acoust. Soc. Am. 111, 2467 (2002)]. Effective onset detection requires low latency and the capacity to cope with wide variation in the dynamic range. Many neurons in the auditory brainstem are sensitive to onsets. The system filters sound into cochlea-like bands (using a Gammatone filterbank), then spike codes positive-going zero-crossings. A wide dynamic range is achieved by using multiple spike trains per filter band, each with different sensitivity. The spike trains from each band innervate a leaky integrate-and-fire neuron. The excitatory synapses from the spike trains are fast and depressing: the shunting inhibitory synapses are facilitating and slower. The combined effect is that the neuron produces a single spike for each onset over a wide dynamic range with very low latency. The use of both inhibitory and excitatory synapses improves onset detection over purely excitatory synapses, leading to a better sound direction finding than previously reported.

  10. Adaptive line enhancers for fast acquisition

    NASA Technical Reports Server (NTRS)

    Yeh, H.-G.; Nguyen, T. M.

    1994-01-01

    Three adaptive line enhancer (ALE) algorithms and architectures - namely, conventional ALE, ALE with double filtering, and ALE with coherent accumulation - are investigated for fast carrier acquisition in the time domain. The advantages of these algorithms are their simplicity, flexibility, robustness, and applicability to general situations including the Earth-to-space uplink carrier acquisition and tracking of the spacecraft. In the acquisition mode, these algorithms act as bandpass filters; hence, the carrier-to-noise ratio (CNR) is improved for fast acquisition. In the tracking mode, these algorithms simply act as lowpass filters to improve signal-to-noise ratio; hence, better tracking performance is obtained. It is not necessary to have a priori knowledge of the received signal parameters, such as CNR, Doppler, and carrier sweeping rate. The implementation of these algorithms is in the time domain (as opposed to the frequency domain, such as the fast Fourier transform (FFT)). The carrier frequency estimation can be updated in real time at each time sample (as opposed to the batch processing of the FFT). The carrier frequency to be acquired can be time varying, and the noise can be non-Gaussian, nonstationary, and colored.

  11. Noise and robustness in phyllotaxis.

    PubMed

    Mirabet, Vincent; Besnard, Fabrice; Vernoux, Teva; Boudaoud, Arezki

    2012-01-01

    A striking feature of vascular plants is the regular arrangement of lateral organs on the stem, known as phyllotaxis. The most common phyllotactic patterns can be described using spirals, numbers from the Fibonacci sequence and the golden angle. This rich mathematical structure, along with the experimental reproduction of phyllotactic spirals in physical systems, has led to a view of phyllotaxis focusing on regularity. However all organisms are affected by natural stochastic variability, raising questions about the effect of this variability on phyllotaxis and the achievement of such regular patterns. Here we address these questions theoretically using a dynamical system of interacting sources of inhibitory field. Previous work has shown that phyllotaxis can emerge deterministically from the self-organization of such sources and that inhibition is primarily mediated by the depletion of the plant hormone auxin through polarized transport. We incorporated stochasticity in the model and found three main classes of defects in spiral phyllotaxis--the reversal of the handedness of spirals, the concomitant initiation of organs and the occurrence of distichous angles--and we investigated whether a secondary inhibitory field filters out defects. Our results are consistent with available experimental data and yield a prediction of the main source of stochasticity during organogenesis. Our model can be related to cellular parameters and thus provides a framework for the analysis of phyllotactic mutants at both cellular and tissular levels. We propose that secondary fields associated with organogenesis, such as other biochemical signals or mechanical forces, are important for the robustness of phyllotaxis. More generally, our work sheds light on how a target pattern can be achieved within a noisy background.

  12. Noise and Robustness in Phyllotaxis

    PubMed Central

    Mirabet, Vincent; Besnard, Fabrice; Vernoux, Teva; Boudaoud, Arezki

    2012-01-01

    A striking feature of vascular plants is the regular arrangement of lateral organs on the stem, known as phyllotaxis. The most common phyllotactic patterns can be described using spirals, numbers from the Fibonacci sequence and the golden angle. This rich mathematical structure, along with the experimental reproduction of phyllotactic spirals in physical systems, has led to a view of phyllotaxis focusing on regularity. However all organisms are affected by natural stochastic variability, raising questions about the effect of this variability on phyllotaxis and the achievement of such regular patterns. Here we address these questions theoretically using a dynamical system of interacting sources of inhibitory field. Previous work has shown that phyllotaxis can emerge deterministically from the self-organization of such sources and that inhibition is primarily mediated by the depletion of the plant hormone auxin through polarized transport. We incorporated stochasticity in the model and found three main classes of defects in spiral phyllotaxis – the reversal of the handedness of spirals, the concomitant initiation of organs and the occurrence of distichous angles – and we investigated whether a secondary inhibitory field filters out defects. Our results are consistent with available experimental data and yield a prediction of the main source of stochasticity during organogenesis. Our model can be related to cellular parameters and thus provides a framework for the analysis of phyllotactic mutants at both cellular and tissular levels. We propose that secondary fields associated with organogenesis, such as other biochemical signals or mechanical forces, are important for the robustness of phyllotaxis. More generally, our work sheds light on how a target pattern can be achieved within a noisy background. PMID:22359496

  13. Robust estimators of palaeosecular variation

    NASA Astrophysics Data System (ADS)

    Suttie, Neil; Biggin, Andrew; Holme, Richard

    2015-02-01

    The Fisher distribution is central to palaeomagnetism but presents several problems when used to characterize geomagnetic field directions as observed in sequences of volcanic rocks. First, it introduces a shallowing effect when used to define the mean of any group of directional unit vectors. This is problematic because it can suggest the presence of persistent non-axial dipole components when none are present. More importantly, it fails to capture the observed `long tail' in distributions of both directions and associated virtual geomagnetic poles in terms of angular distance from a central direction. To achieve a good fit to data, it therefore requires the introduction of a second distribution (and therefore the estimation of additional parameters) or the arbitrary removal of data. Here we present a new distribution to describe palaeomagnetic directions and demonstrate that it overcomes both of these problems, generating robust indicators of both the central direction (or pole position) and the spread of palaeomagnetic data as defined by unit vectors. Starting from the assumption that poles (or directions) have an expected colatitude, rather than a mean location, we derive the spherical exponential distribution. We demonstrate that this new distribution provides a good fit to palaeomagnetic data sets from seven large igneous provinces between 15 and 65 Ma and also those produced by numerical dynamo models. We also use it to derive a new shape parameter which may be used as a diagnostic tool for testing goodness of fit of models to data and use this to argue for a shift in geomagnetic behaviour between 5 and 15 Ma. Furthermore, we point out that this new statistic can be used to determine the most appropriate distribution to be used when constructing confidence limits for poles.

  14. Robust control with structured perturbations

    NASA Technical Reports Server (NTRS)

    Keel, Leehyun

    1988-01-01

    Two important problems in the area of control systems design and analysis are discussed. The first is the robust stability using characteristic polynomial, which is treated first in characteristic polynomial coefficient space with respect to perturbations in the coefficients of the characteristic polynomial, and then for a control system containing perturbed parameters in the transfer function description of the plant. In coefficient space, a simple expression is first given for the l(sup 2) stability margin for both monic and non-monic cases. Following this, a method is extended to reveal much larger stability region. This result has been extended to the parameter space so that one can determine the stability margin, in terms of ranges of parameter variations, of the closed loop system when the nominal stabilizing controller is given. The stability margin can be enlarged by a choice of better stabilizing controller. The second problem describes the lower order stabilization problem, the motivation of the problem is as follows. Even though the wide range of stabilizing controller design methodologies is available in both the state space and transfer function domains, all of these methods produce unnecessarily high order controllers. In practice, the stabilization is only one of many requirements to be satisfied. Therefore, if the order of a stabilizing controller is excessively high, one can normally expect to have a even higher order controller on the completion of design such as inclusion of dynamic response requirements, etc. Therefore, it is reasonable to have a lowest possible order stabilizing controller first and then adjust the controller to meet additional requirements. The algorithm for designing a lower order stabilizing controller is given. The algorithm does not necessarily produce the minimum order controller; however, the algorithm is theoretically logical and some simulation results show that the algorithm works in general.

  15. Systematic design methods of robust and structured controllers for satellites. Application to the refinement of Rosetta's orbit controller

    NASA Astrophysics Data System (ADS)

    Falcoz, Alexandre; Pittet, Christelle; Bennani, Samir; Guignard, Anne; Bayart, Cedric; Frapard, Benoit

    2015-09-01

    In this paper, the capability of nonsmooth optimisation techniques to solve complex control problems with implementation issues is addressed. {H}_{∞}/ μ design methods are analysed to enhance the current Airbus Defence and Space industrial development process. In the first instance, a reference μ-synthesis controller that achieves the desired robust performance level is designed. Second, a controller obeying the same initial design objectives is synthesized using a predefined fixed structure and order. This time, the controller is realised using a fixed-structure-based μ-synthesis approach involving a nonsmooth optimisation algorithm provided in the Matlab R2011b Robust Control Toolbox. Finally, a practical structured {H}_{∞} multi-model approach closer to Airbus Defence and Space development practices is proposed. The different methodologies are applied to synthesize the Chemical Station Keeping controllers of a flexible Eurostar E3000 satellite and a comparative performance robustness analysis is provided. Hinfstruct has now been established in the Airbus Defence and Space industrial process. Recently, it has been successfully used to rapidly refine the orbit controller of Rosetta Space Probe before the critical rendezvous with Comet 67P/Churyumov-Gerasimenko. A specific section will be devoted on this point and in-flight data will be presented.

  16. Does Ramadan fasting affect sleep?

    PubMed

    Bahammam, A

    2006-12-01

    Experimental fasting has been shown to alter the sleep-wakefulness pattern in various species. As fasting during Ramadan is distinct from experimental fasting, the physiological and behavioural changes occurring during Ramadan fasting may differ from those occurring during experimental fasting. There has been increased interest in recent years in sleep changes and daytime sleepiness during Ramadan. Moreover, many of those who fast during Ramadan associate this fasting with increased daytime sleepiness and decreased performance. This raises the question of whether Ramadan fasting affects sleep. In this review, we discuss the findings of research conducted to assess changes in sleep pattern, chronobiology, circadian rhythms, daytime sleepiness and function and sleep architecture during the month of Ramadan. Where applicable, these findings are compared with those obtained during experimental fasting.

  17. Robust GPS carrier tracking under ionospheric scintillation

    NASA Astrophysics Data System (ADS)

    Susi, M.; Andreotti, M.; Aquino, M. H.; Dodson, A.

    2013-12-01

    Small scale irregularities present in the ionosphere can induce fast and unpredictable fluctuations of Radio Frequency (RF) signal phase and amplitude. This phenomenon, known as scintillation, can degrade the performance of a GPS receiver leading to cycle slips, increasing the tracking error and also producing a complete loss of lock. In the most severe scenarios, if the tracking of multiple satellites links is prevented, outages in the GPS service can also occur. In order to render a GPS receiver more robust under scintillation, particular attention should be dedicated to the design of the carrier tracking stage, that is the receiver's part most sensitive to these types of phenomenon. This paper exploits the reconfigurability and flexibility of a GPS software receiver to develop a tracking algorithm that is more robust under ionospheric scintillation. For this purpose, first of all, the scintillation level is monitored in real time. Indeed the carrier phase and the post correlation terms obtained by the PLL (Phase Locked Loop) are used to estimate phi60 and S4 [1], the scintillation indices traditionally used to quantify the level of phase and amplitude scintillations, as well as p and T, the spectral parameters of the fluctuations PSD. The effectiveness of the scintillation parameter computation is confirmed by comparing the values obtained by the software receiver and the ones provided by a commercial scintillation monitoring, i.e. the Septentrio PolarxS receiver [2]. Then the above scintillation parameters and the signal carrier to noise density are exploited to tune the carrier tracking algorithm. In case of very weak signals the FLL (Frequency Locked Loop) scheme is selected in order to maintain the signal lock. Otherwise an adaptive bandwidth Phase Locked Loop (PLL) scheme is adopted. The optimum bandwidth for the specific scintillation scenario is evaluated in real time by exploiting the Conker formula [1] for the tracking jitter estimation. The performance

  18. Not So Fast: Hippocampal Amnesia Slows Word Learning Despite Successful Fast Mapping

    PubMed Central

    Warren, David E.; Duff, Melissa C.

    2015-01-01

    The human hippocampus is widely believed to be necessary for the rapid acquisition of new declarative relational memories. However, processes supporting on-line inferential word use (“fast mapping”) may also exercise a dissociable learning mechanism and permit rapid word learning without the hippocampus (Sharon et al. (2011) Proc Natl Acad Sci USA 108:1146–1151). We investigated fast mapping in severely amnesic patients with hippocampal damage (N = 4), mildly amnesic patients (N = 6), and healthy comparison participants (N = 10) using on-line measures (eye movements) that reflected ongoing processing. All participants studied unique word-picture associations in two encoding conditions. In the explicit-encoding condition, uncommon items were paired with their names (e.g., “This is a numbat.”). In the fast mapping study condition, participants heard an instruction using a novel word (e.g., “Click on the numbat.”) while two items were presented (an uncommon target such as a numbat, and a common distracter such as a dog). All groups performed fast mapping well at study, and on-line eye movement measures did not reveal group differences. However, while comparison participants showed robust word learning irrespective of encoding condition, severely amnesic patients showed no evidence of learning after fast mapping or explicit encoding on any behavioral or eye-movement measure. Mildly amnesic patients showed some learning, but performance was unaffected by encoding condition. The findings are consistent with the following propositions: the hippocampus is not essential for on-line fast mapping of novel words; but is necessary for the rapid learning of arbitrary relational information irrespective of encoding conditions. PMID:24719218

  19. The Utility of Robust Means in Statistics

    ERIC Educational Resources Information Center

    Goodwyn, Fara

    2012-01-01

    Location estimates calculated from heuristic data were examined using traditional and robust statistical methods. The current paper demonstrates the impact outliers have on the sample mean and proposes robust methods to control for outliers in sample data. Traditional methods fail because they rely on the statistical assumptions of normality and…

  20. Robust LQR control for the benchmark problem

    NASA Technical Reports Server (NTRS)

    Douglas, Joel; Athans, Michael

    1991-01-01

    An examination is made of the performance of a linear quadratic regulator which is robust to parametric uncertainty. The controller, which feeds back all states, is based upon Petersen's approach. Simulations show, using the benchmark problem, that remarkable performance robustness can be achieved.

  1. Robust Controller Design for Hemispherical Resonator Gyroscope

    DTIC Science & Technology

    2011-11-01

    f v Figure 1. Operating principle of HRG Robust Controller Design for Hemispherical Resonator Gyroscope Chul Hyun1), Byung ...Petersburg, Russia.: 26-34 4) Chul Hyun. 2011. Design of Robust Digital Controller for Hemispherical Resonator Gyroscopes, Ph.D. dissertation, Seoul

  2. Evaluating efficiency and robustness in cilia design

    NASA Astrophysics Data System (ADS)

    Guo, Hanliang; Kanso, Eva

    2016-03-01

    Motile cilia are used by many eukaryotic cells to transport flow. Cilia-driven flows are important to many physiological functions, yet a deep understanding of the interplay between the mechanical structure of cilia and their physiological functions in healthy and diseased conditions remains elusive. To develop such an understanding, one needs a quantitative framework to assess cilia performance and robustness when subject to perturbations in the cilia apparatus. Here we link cilia design (beating patterns) to function (flow transport) in the context of experimentally and theoretically derived cilia models. We particularly examine the optimality and robustness of cilia design. Optimality refers to efficiency of flow transport, while robustness is defined as low sensitivity to variations in the design parameters. We find that suboptimal designs can be more robust than optimal ones. That is, designing for the most efficient cilium does not guarantee robustness. These findings have significant implications on the understanding of cilia design in artificial and biological systems.

  3. Environmental change makes robust ecological networks fragile

    PubMed Central

    Strona, Giovanni; Lafferty, Kevin D.

    2016-01-01

    Complex ecological networks appear robust to primary extinctions, possibly due to consumers' tendency to specialize on dependable (available and persistent) resources. However, modifications to the conditions under which the network has evolved might alter resource dependability. Here, we ask whether adaptation to historical conditions can increase community robustness, and whether such robustness can protect communities from collapse when conditions change. Using artificial life simulations, we first evolved digital consumer-resource networks that we subsequently subjected to rapid environmental change. We then investigated how empirical host–parasite networks would respond to historical, random and expected extinction sequences. In both the cases, networks were far more robust to historical conditions than new ones, suggesting that new environmental challenges, as expected under global change, might collapse otherwise robust natural ecosystems. PMID:27511722

  4. Environmental change makes robust ecological networks fragile

    USGS Publications Warehouse

    Strona, Giovanni; Lafferty, Kevin D.

    2016-01-01

    Complex ecological networks appear robust to primary extinctions, possibly due to consumers’ tendency to specialize on dependable (available and persistent) resources. However, modifications to the conditions under which the network has evolved might alter resource dependability. Here, we ask whether adaptation to historical conditions can increase community robustness, and whether such robustness can protect communities from collapse when conditions change. Using artificial life simulations, we first evolved digital consumer-resource networks that we subsequently subjected to rapid environmental change. We then investigated how empirical host–parasite networks would respond to historical, random and expected extinction sequences. In both the cases, networks were far more robust to historical conditions than new ones, suggesting that new environmental challenges, as expected under global change, might collapse otherwise robust natural ecosystems.

  5. Fast electrochemical actuator

    NASA Astrophysics Data System (ADS)

    Uvarov, I. V.; Postnikov, A. V.; Svetovoy, V. B.

    2016-03-01

    Lack of fast and strong microactuators is a well-recognized problem in MEMS community. Electrochemical actuators can develop high pressure but they are notoriously slow. Water electrolysis produced by short voltage pulses of alternating polarity can overcome the problem of slow gas termination. Here we demonstrate an actuation regime, for which the gas pressure is relaxed just for 10 μs or so. The actuator consists of a microchamber filled with the electrolyte and covered with a flexible membrane. The membrane bends outward when the pressure in the chamber increases. Fast termination of gas and high pressure developed in the chamber are related to a high density of nanobubbles in the chamber. The physical processes happening in the chamber are discussed so as problems that have to be resolved for practical applications of this actuation regime. The actuator can be used as a driving engine for microfluidics.

  6. A fast template periodogram

    NASA Astrophysics Data System (ADS)

    Hoffman, John; VanderPlas, Jake; Hartman, Joel; Bakos, Gáspár

    2017-09-01

    This proceedings contribution presents a novel, non-linear extension to the Lomb-Scargle periodogram that allows periodograms to be generated for arbitrary signal shapes. Such periodograms are already known as "template periodograms" or "periodic matched filters," but current implementations are computationally inefficient. The "fast template periodogram" presented here improves existing techniques by a factor of ˜a few for small test cases (O(10) observations), and over three orders of magnitude for lightcurves containing O(104) observations. The fast template periodogram scales asymptotically as O(HNf log HNf + H4Nf), where H denotes the number of harmonics required to adequately approximate the template and Nf is the number of trial frequencies. Existing implementations scale as O(NobsNf), where Nobs is the number of observations in the lightcurve. An open source Python implementation is available on GitHub.

  7. Fast tracking hospital construction.

    PubMed

    Quirk, Andrew

    2013-03-01

    Hospital leaders should consider four factors in determining whether to fast track a hospital construction project: Expectations of project length, quality, and cost. Whether decisions can be made quickly as issues arise. Their own time commitment to the project, as well as that of architects, engineers, construction managers, and others. The extent to which they are willing to share with the design and construction teams how and why decisions are being made.

  8. PHENIX Fast TOF

    SciTech Connect

    Soha, Aria; Chiu, Mickey; Mannel, Eric; Stoll, Sean; Lynch, Don; Boose, Steve; Northacker, Dave; Alfred, Marcus; Lindesay, James; Chujo, Tatsuya; Inaba, Motoi; Nonaka, Toshihiro; Sato, Wataru; Sakatani, Ikumi; Hirano, Masahiro; Choi, Ihnjea

    2014-01-15

    This is a technical scope of work (TSW) between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of PHENIX Fast TOF group who have committed to participate in beam tests to be carried out during the FY2014 Fermilab Test Beam Facility program. The goals for this test beam experiment are to verify the timing performance of the two types of time-of-flight detector prototypes.

  9. The Integral Fast Reactor

    SciTech Connect

    Chang, Y.I.

    1988-01-01

    The Integral Fast Reactor (IFR) is an innovative liquid metal reactor concept being developed at Argonne National Laboratory. It seeks to specifically exploit the inherent properties of liquid metal cooling and metallic fuel in a way that leads to substantial improvements in the characteristics of the complete reactor system. This paper describes the key features and potential advantages of the IFR concept, with emphasis on its safety characteristics. 3 refs., 4 figs., 1 tab.

  10. Fast Radio Bursts

    NASA Astrophysics Data System (ADS)

    Rane, Akshaya; Lorimer, Duncan

    2017-09-01

    We summarize our current state of knowledge of fast radio bursts (FRBs) which were first discovered a decade ago. Following an introduction to radio transients in general, including pulsars and rotating radio transients, we discuss the discovery of FRBs. We then discuss FRB follow-up observations in the context of repeat bursts before moving on to review propagation effects on FRB signals, FRB progenitor models and an outlook on FRBs as potential cosmological tools.

  11. Fast Ion Conductors

    NASA Astrophysics Data System (ADS)

    Chadwick, Alan V.

    Fast ion conductors, sometimes referred to as superionic conductors or solid electrolytes, are solids with ionic conductivities that are comparable to those found in molten salts and aqueous solutions of strong electrolytes, i.e., 10-2-10 S cm-1. Such materials have been known of for a very long time and some typical examples of the conductivity are shown in Fig. 1, along with sodium chloride as the archetypal normal ionic solid. Faraday [1] first noted the high conductivity of solid lead fluoride (PbF2) and silver sulphide (Ag2S) in the 1830s and silver iodide was known to be unusually high ionic conductor to the German physicists early in the 1900s. However, the materials were regarded as anomalous until the mid 1960s when they became the focus of intense interest to academics and technologists and they have remained at the forefront of materials research [2-4]. The academic aim is to understand the fundamental origin of fast ion behaviour and the technological goal is to utilize the properties in applications, particularly in energy applications such as the electrolyte membranes in solid-state batteries and fuel cells, and in electrochemical sensors. The last four decades has seen an expansion of the types of material that exhibit fast ion behaviour that now extends beyond simple binary ionic crystals to complex solids and even polymeric materials. Over this same period computer simulations of solids has also developed (in fact these methods and the interest in fast ion conductors were almost coincidental in their time of origin) and the techniques have played a key role in this area of research.

  12. "Fast" Capitalism and "Fast" Schools: New Realities and New Truths.

    ERIC Educational Resources Information Center

    Robertson, Susan L.

    This paper locates the phenomenon of self-managing schools within the framework of "fast capitalism" and identifies themes of organization central to fast capitalism, which are argued to also underpin the self-managing schools. "Fast capitalism" refers to the rapidly intensified integration of regionalized productive activities into the global…

  13. Fast Track Study

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The NASA Fast Track Study supports the efforts of a Special Study Group (SSG) made up of members of the Advanced Project Management Class number 23 (APM-23) that met at the Wallops Island Management Education Center from April 28 - May 8, 1996. Members of the Class expressed interest to Mr. Vem Weyers in having an input to the NASA Policy Document (NPD) 7120.4, that will replace NASA Management Institute (NMI) 7120.4, and the NASA Program/Project Management Guide. The APM-23 SSG was tasked with assisting in development of NASA policy on managing Fast Track Projects, defined as small projects under $150 million and completed within three years. 'Me approach of the APM-23 SSG was to gather data on successful projects working in a 'Better, Faster, Cheaper' environment, within and outside of NASA and develop the Fast Track Project section of the NASA Program/Project Management Guide. Fourteen interviews and four other data gathering efforts were conducted by the SSG, and 16 were conducted by Strategic Resources, Inc. (SRI), including five interviews at the Jet Propulsion Laboratory (JPL) and one at the Applied Physics Laboratory (APL). The interviews were compiled and analyzed for techniques and approaches commonly used to meet severe cost and schedule constraints.

  14. Fast ignitor coupling physics

    SciTech Connect

    Mason, R.J.; Tabak, M.

    1997-10-01

    The Fast Ignitor is an alternate approach to ICF in which short pulse lasers are used to initiate burn at the surface of the compressed DT fuel. The aim is to avoid the need for careful central focusing of final shocks, and possibly to lower substantially the energy requirements for ignition. Ultimately, both goals may prove crucial to Science Based Stockpile Stewardship (SBSS). This will be the case should either emerging energetic needs, or funding difficulties render the presently planned radiative fusion approach to ignition with the NIF impractical. Ignition is a first step towards the achievement of substantial energy and neutron outputs for such Stewardship. For success with the Fast Ignitor, the laser energy must be efficiently deposited into megavolt electrons (suprathermal), which must, in turn, couple to the background ions within an alpha particle range. To understand the electron fuel coupling, we have used ANTHEM plasma simulation code to model the transport of hot electrons generated by an intense short pulse laser into plasma targets over a broad range of densities. Our study will spell out the acceleration and transport mechanisms active in the Fast Ignitor environment.

  15. Lipid metabolism during fasting.

    PubMed

    Jensen, M D; Ekberg, K; Landau, B R

    2001-10-01

    These studies were conducted to understand the relationship between measures of systemic free fatty acid (FFA) reesterification and regional FFA, glycerol, and triglyceride metabolism during fasting. Indirect calorimetry was used to measure fatty acid oxidation in six men after a 60-h fast. Systemic and regional (splanchnic, renal, and leg) FFA ([(3)H]palmitate) and glycerol ([(3)H]glycerol) kinetics, as well as splanchnic triglyceride release, were measured. The rate of systemic FFA reesterification was 366 +/- 93 micromol/min, which was greater (P < 0.05) than splanchnic triglyceride fatty acid output (64 +/- 6 micromol/min), a measure of VLDL triglyceride fatty acid export. The majority of glycerol uptake occurred in the splanchnic and renal beds, although some leg glycerol uptake was detected. Systemic FFA release was approximately double that usually present in overnight postabsorptive men, yet the regional FFA release rates were of the same proportions previously observed in overnight postabsorptive men. In conclusion, FFA reesterification at rest during fasting far exceeds splanchnic triglyceride fatty acid output. This indicates that nonhepatic sites of FFA reesterification are important, and that peripheral reesterification of FFA exceeds the rate of simultaneous intracellular triglyceride fatty acid oxidation.

  16. Fasting - the ultimate diet?

    PubMed

    Johnstone, A M

    2007-05-01

    Adult humans often undertake acute fasts for cosmetic, religious or medical reasons. For example, an estimated 14% of US adults have reported using fasting as a means to control body weight and this approach has long been advocated as an intermittent treatment for gross refractory obesity. There are unique historical data sets on extreme forms of food restriction that give insight into the consequences of starvation or semi-starvation in previously healthy, but usually non-obese subjects. These include documented medical reports on victims of hunger strike, famine and prisoners of war. Such data provide a detailed account on how the body adapts to prolonged starvation. It has previously been shown that fasting for the biblical period of 40 days and 40 nights is well within the overall physiological capabilities of a healthy adult. However, the specific effects on the human body and mind are less clearly documented, either in the short term (hours) or in the longer term (days). This review asks the following three questions, pertinent to any weight-loss therapy, (i) how effective is the regime in achieving weight loss, (ii) what impact does it have on psychology? and finally, (iii) does it work long-term?

  17. Fast Light Optical Gyroscopes

    NASA Technical Reports Server (NTRS)

    Smith, David D.

    2015-01-01

    Next-generation space missions are currently constrained by existing spacecraft navigation systems which are not fully autonomous. These systems suffer from accumulated dead-reckoning errors and must therefore rely on periodic corrections provided by supplementary technologies that depend on line-of-sight signals from Earth, satellites, or other celestial bodies for absolute attitude and position determination, which can be spoofed, incorrectly identified, occluded, obscured, attenuated, or insufficiently available. These dead-reckoning errors originate in the ring laser gyros themselves, which constitute inertial measurement units. Increasing the time for standalone spacecraft navigation therefore requires fundamental improvements in gyroscope technologies. One promising solution to enhance gyro sensitivity is to place an anomalous dispersion or fast light material inside the gyro cavity. The fast light essentially provides a positive feedback to the gyro response, resulting in a larger measured beat frequency for a given rotation rate as shown in figure 1. Game Changing Development has been investing in this idea through the Fast Light Optical Gyros (FLOG) project, a collaborative effort which began in FY 2013 between NASA Marshall Space Flight Center (MSFC), the U.S. Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC), and Northwestern University. MSFC and AMRDEC are working on the development of a passive FLOG (PFLOG), while Northwestern is developing an active FLOG (AFLOG). The project has demonstrated new benchmarks in the state of the art for scale factor sensitivity enhancement. Recent results show cavity scale factor enhancements of approx.100 for passive cavities.

  18. Robust and efficient estimation with weighted composite quantile regression

    NASA Astrophysics Data System (ADS)

    Jiang, Xuejun; Li, Jingzhi; Xia, Tian; Yan, Wanfeng

    2016-09-01

    In this paper we introduce a weighted composite quantile regression (CQR) estimation approach and study its application in nonlinear models such as exponential models and ARCH-type models. The weighted CQR is augmented by using a data-driven weighting scheme. With the error distribution unspecified, the proposed estimators share robustness from quantile regression and achieve nearly the same efficiency as the oracle maximum likelihood estimator (MLE) for a variety of error distributions including the normal, mixed-normal, Student's t, Cauchy distributions, etc. We also suggest an algorithm for the fast implementation of the proposed methodology. Simulations are carried out to compare the performance of different estimators, and the proposed approach is used to analyze the daily S&P 500 Composite index, which verifies the effectiveness and efficiency of our theoretical results.

  19. Robust Approach for Nonuniformity Correction in Infrared Focal Plane Array

    PubMed Central

    Boutemedjet, Ayoub; Deng, Chenwei; Zhao, Baojun

    2016-01-01

    In this paper, we propose a new scene-based nonuniformity correction technique for infrared focal plane arrays. Our work is based on the use of two well-known scene-based methods, namely, adaptive and interframe registration-based exploiting pure translation motion model between frames. The two approaches have their benefits and drawbacks, which make them extremely effective in certain conditions and not adapted for others. Following on that, we developed a method robust to various conditions, which may slow or affect the correction process by elaborating a decision criterion that adapts the process to the most effective technique to ensure fast and reliable correction. In addition to that, problems such as bad pixels and ghosting artifacts are also dealt with to enhance the overall quality of the correction. The performance of the proposed technique is investigated and compared to the two state-of-the-art techniques cited above. PMID:27834893

  20. Metabolic Effects of Intermittent Fasting.

    PubMed

    Patterson, Ruth E; Sears, Dorothy D

    2017-08-21

    The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human health. Intermittent fasting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such as sleep. If proven to be efficacious, these eating regimens offer promising nonpharmacological approaches to improving health at the population level, with multiple public health benefits.

  1. Neighborhood fast food availability and fast food consumption.

    PubMed

    Oexle, Nathalie; Barnes, Timothy L; Blake, Christine E; Bell, Bethany A; Liese, Angela D

    2015-09-01

    Recent nutritional and public health research has focused on how the availability of various types of food in a person's immediate area or neighborhood influences his or her food choices and eating habits. It has been theorized that people living in areas with a wealth of unhealthy fast-food options may show higher levels of fast-food consumption, a factor that often coincides with being overweight or obese. However, measuring food availability in a particular area is difficult to achieve consistently: there may be differences in the strict physical locations of food options as compared to how individuals perceive their personal food availability, and various studies may use either one or both of these measures. The aim of this study was to evaluate the association between weekly fast-food consumption and both a person's perceived availability of fast-food and an objective measure of fast-food presence - Geographic Information Systems (GIS) - within that person's neighborhood. A randomly selected population-based sample of eight counties in South Carolina was used to conduct a cross-sectional telephone survey assessing self-report fast-food consumption and perceived availability of fast food. GIS was used to determine the actual number of fast-food outlets within each participant's neighborhood. Using multinomial logistic regression analyses, we found that neither perceived availability nor GIS-based presence of fast-food was significantly associated with weekly fast-food consumption. Our findings indicate that availability might not be the dominant factor influencing fast-food consumption. We recommend using subjective availability measures and considering individual characteristics that could influence both perceived availability of fast food and its impact on fast-food consumption. If replicated, our findings suggest that interventions aimed at reducing fast-food consumption by limiting neighborhood fast-food availability might not be completely effective.

  2. Neighborhood fast food availability and fast food consumption

    PubMed Central

    Oexle, Nathalie; Barnes, Timothy L; Blake, Christine E; Bell, Bethany A; Liese, Angela D

    2015-01-01

    Recent nutritional and public health research has focused on how the availability of various types of food in a person’s immediate area or neighborhood influences his or her food choices and eating habits. It has been theorized that people living in areas with a wealth of unhealthy fast-food options may show higher levels of fast-food consumption, a factor that often coincides with being overweight or obese. However, measuring food availability in a particular area is difficult to achieve consistently: there may be differences in the strict physical locations of food options as compared to how individuals perceive their personal food availability, and various studies may use either one or both of these measures. The aim of this study was to evaluate the association between weekly fast-food consumption and both a person’s perceived availability of fast-food and an objective measure of fast-food presence—Geographic Information Systems (GIS)—within that person’s neighborhood. A randomly selected population-based sample of eight counties in South Carolina was used to conduct a cross-sectional telephone survey assessing self-report fast-food consumption and perceived availability of fast food. GIS was used to determine the actual number of fast-food outlets within each participant’s neighborhood. Using multinomial logistic regression analyses, we found that neither perceived availability nor GIS-based presence of fast-food was significantly associated with weekly fast-food consumption. Our findings indicate that availability might not be the dominant factor influencing fast-food consumption. We recommend using subjective availability measures and considering individual characteristics that could influence both perceived availability of fast food and its impact on fast-food consumption. If replicated, our findings suggest that interventions aimed at reducing fast-food consumption by limiting neighborhood fast-food availability might not be completely

  3. Stochastic Satbility and Performance Robustness of Linear Multivariable Systems

    NASA Technical Reports Server (NTRS)

    Ryan, Laurie E.; Stengel, Robert F.

    1990-01-01

    Stochastic robustness, a simple technique used to estimate the robustness of linear, time invariant systems, is applied to a single-link robot arm control system. Concepts behind stochastic stability robustness are extended to systems with estimators and to stochastic performance robustness. Stochastic performance robustness measures based on classical design specifications are introduced, and the relationship between stochastic robustness measures and control system design parameters are discussed. The application of stochastic performance robustness, and the relationship between performance objectives and design parameters are demonstrated by means of example. The results prove stochastic robustness to be a good overall robustness analysis method that can relate robustness characteristics to control system design parameters.

  4. Robust hybrid elastomer/metal-oxide superhydrophobic surfaces.

    PubMed

    Hoshian, S; Jokinen, V; Franssila, S

    2016-08-21

    We introduce a new type of hybrid material: a nanostructured elastomer covered by a hard photoactive metal-oxide thin film resembling the exoskeleton of insects. It has extreme water repellency and fast self-recovery after damage. A new fabrication method for replicating high aspect ratio, hierarchical re-entrant aluminum structures into polydimethylsiloxane (PDMS) is presented. The method is based on a protective titania layer deposited by atomic layer deposition (ALD) on the aluminum template. The ALD titania transfers to the elastomeric scaffold via sacrificial release etching. The sacrificial release method allows for high aspect ratio, even 100 μm deep and successful release of overhanging structures, unlike conventional peeling. The ALD titania conformally covers the 3D multihierarchical structures of the template and protects the polymer during the release etch. Afterwards it prevents the high aspect ratio nanostructures from elasticity based collapse. The resulting nanostructured hybrid PDMS/titania replicas display robust superhydrophobicity without any further fluoro-coating or modification. Their mechanical and thermal robustness results from a thick nanostructured elastomeric layer which is conformally covered by ceramic titania instead of a monolayer hydrophobic coating. We have demonstrated the durability of these replicas against mechanical abrasion, knife scratches, rubbing, bending, peel tape test, high temperature annealing, UV exposure, water jet impingement and long term underwater storage. Though the material loses its superhydrophobicity in oxygen plasma exposure, a fast recovery from superhydrophilic to superhydrophobic can be achieved after 20 min UV irradiation. UV-assisted recovery is correlated with the high photoactivity of ALD titania film. This novel hybrid material will be applicable to the large area superhydrophobic surfaces in practical outdoor applications.

  5. Defining robustness protocols: a method to include and evaluate robustness in clinical plans

    NASA Astrophysics Data System (ADS)

    McGowan, S. E.; Albertini, F.; Thomas, S. J.; Lomax, A. J.

    2015-04-01

    We aim to define a site-specific robustness protocol to be used during the clinical plan evaluation process. Plan robustness of 16 skull base IMPT plans to systematic range and random set-up errors have been retrospectively and systematically analysed. This was determined by calculating the error-bar dose distribution (ebDD) for all the plans and by defining some metrics used to define protocols aiding the plan assessment. Additionally, an example of how to clinically use the defined robustness database is given whereby a plan with sub-optimal brainstem robustness was identified. The advantage of using different beam arrangements to improve the plan robustness was analysed. Using the ebDD it was found range errors had a smaller effect on dose distribution than the corresponding set-up error in a single fraction, and that organs at risk were most robust to the range errors, whereas the target was more robust to set-up errors. A database was created to aid planners in terms of plan robustness aims in these volumes. This resulted in the definition of site-specific robustness protocols. The use of robustness constraints allowed for the identification of a specific patient that may have benefited from a treatment of greater individuality. A new beam arrangement showed to be preferential when balancing conformality and robustness for this case. The ebDD and error-bar volume histogram proved effective in analysing plan robustness. The process of retrospective analysis could be used to establish site-specific robustness planning protocols in proton therapy. These protocols allow the planner to determine plans that, although delivering a dosimetrically adequate dose distribution, have resulted in sub-optimal robustness to these uncertainties. For these cases the use of different beam start conditions may improve the plan robustness to set-up and range uncertainties.

  6. Robust smoothing of gridded data in one and higher dimensions with missing values.

    PubMed

    Garcia, Damien

    2010-04-01

    A fully automated smoothing procedure for uniformly-sampled datasets is described. The algorithm, based on a penalized least squares method, allows fast smoothing of data in one and higher dimensions by means of the discrete cosine transform. Automatic choice of the amount of smoothing is carried out by minimizing the generalized cross-validation score. An iteratively weighted robust version of the algorithm is proposed to deal with occurrences of missing and outlying values. Simplified Matlab codes with typical examples in one to three dimensions are provided. A complete user-friendly Matlab program is also supplied. The proposed algorithm - very fast, automatic, robust and requiring low storage -provides an efficient smoother for numerous applications in the area of data analysis.

  7. Robust smoothing of gridded data in one and higher dimensions with missing values

    PubMed Central

    Garcia, Damien

    2013-01-01

    A fully automated smoothing procedure for uniformly-sampled datasets is described. The algorithm, based on a penalized least squares method, allows fast smoothing of data in one and higher dimensions by means of the discrete cosine transform. Automatic choice of the amount of smoothing is carried out by minimizing the generalized cross-validation score. An iteratively weighted robust version of the algorithm is proposed to deal with occurrences of missing and outlying values. Simplified Matlab codes with typical examples in one to three dimensions are provided. A complete user-friendly Matlab program is also supplied. The proposed algorithm – very fast, automatic, robust and requiring low storage –provides an efficient smoother for numerous applications in the area of data analysis. PMID:24795488

  8. Robustness properties of circadian clock architectures

    PubMed Central

    Stelling, Jörg; Gilles, Ernst Dieter; Doyle, Francis J.

    2004-01-01

    Robustness, a relative insensitivity to perturbations, is a key characteristic of living cells. However, the specific structural characteristics that are responsible for robust performance are not clear, even in genetic circuits of moderate complexity. Formal sensitivity analysis allows the investigation of robustness and fragility properties of mathematical models representing regulatory networks, but it yields only local properties with respect to a particular choice of parameter values. Here, we show that by systematically investigating the parameter space, more global properties linked to network structure can be derived. Our analysis focuses on the genetic oscillator responsible for generating circadian rhythms in Drosophila as a prototypic dynamical cellular system. Analysis of two mathematical models of moderate complexity shows that the tradeoff between robustness and fragility is largely determined by the regulatory structure. Rank-ordered sensitivities, for instance, allow the correct identification of protein phosphorylation as an influential process determining the oscillator's period. Furthermore, sensitivity analysis confirms the theoretical insight that hierarchical control might be important for achieving robustness. The complex feedback structures encountered in vivo, however, do not seem to enhance robustness per se but confer robust precision and adjustability of the clock while avoiding catastrophic failure. PMID:15340155

  9. Evolution, robustness, and the cost of complexity

    NASA Astrophysics Data System (ADS)

    Leclerc, Robert D.

    Evolutionary systems biology is the study of how regulatory networks evolve under the influence of natural selection, mutation, and the environment. It attempts to explain the dynamics, architecture, and variational properties of regulatory networks and how this relates to the origins, evolution and maintenance of complex and diverse functions. Key questions in the field of evolutionary systems biology ask how does robustness evolve, what are the factors that drive its evolution, and what are the underlying mechanisms that discharge robustness? In this dissertation, I investigate the evolution of robustness in artificial gene regulatory networks. I show how different conceptions of robustness fit together as pieces of a general notion of robustness, and I show how this relationship implies potential tradeoffs in how robustness can be implemented. I present results which suggest that inherent logistical problems with genetic recombination may help drive the evolution of modularity in the genotype-phenotype map. Finally, I show that robustness implies a parsimonious network structure, one which is sparsely connected and not unnecessarily complex. These results challenge conclusions drawn from many high-profile studies, and may offer a broad new perspective on biological systems. Because life must orchestrate its existence on random nonlinear thermodynamic processes, it will be designed and implemented in the most probable way. Life turns the law of entropy back onto itself to root out every inefficiency, waste, and every surprise.

  10. Biological robustness: paradigms, mechanisms, and systems principles.

    PubMed

    Whitacre, James Michael

    2012-01-01

    Robustness has been studied through the analysis of data sets, simulations, and a variety of experimental techniques that each have their own limitations but together confirm the ubiquity of biological robustness. Recent trends suggest that different types of perturbation (e.g., mutational, environmental) are commonly stabilized by similar mechanisms, and system sensitivities often display a long-tailed distribution with relatively few perturbations representing the majority of sensitivities. Conceptual paradigms from network theory, control theory, complexity science, and natural selection have been used to understand robustness, however each paradigm has a limited scope of applicability and there has been little discussion of the conditions that determine this scope or the relationships between paradigms. Systems properties such as modularity, bow-tie architectures, degeneracy, and other topological features are often positively associated with robust traits, however common underlying mechanisms are rarely mentioned. For instance, many system properties support robustness through functional redundancy or through response diversity with responses regulated by competitive exclusion and cooperative facilitation. Moreover, few studies compare and contrast alternative strategies for achieving robustness such as homeostasis, adaptive plasticity, environment shaping, and environment tracking. These strategies share similarities in their utilization of adaptive and self-organization processes that are not well appreciated yet might be suggestive of reusable building blocks for generating robust behavior.

  11. Biological Robustness: Paradigms, Mechanisms, and Systems Principles

    PubMed Central

    Whitacre, James Michael

    2012-01-01

    Robustness has been studied through the analysis of data sets, simulations, and a variety of experimental techniques that each have their own limitations but together confirm the ubiquity of biological robustness. Recent trends suggest that different types of perturbation (e.g., mutational, environmental) are commonly stabilized by similar mechanisms, and system sensitivities often display a long-tailed distribution with relatively few perturbations representing the majority of sensitivities. Conceptual paradigms from network theory, control theory, complexity science, and natural selection have been used to understand robustness, however each paradigm has a limited scope of applicability and there has been little discussion of the conditions that determine this scope or the relationships between paradigms. Systems properties such as modularity, bow-tie architectures, degeneracy, and other topological features are often positively associated with robust traits, however common underlying mechanisms are rarely mentioned. For instance, many system properties support robustness through functional redundancy or through response diversity with responses regulated by competitive exclusion and cooperative facilitation. Moreover, few studies compare and contrast alternative strategies for achieving robustness such as homeostasis, adaptive plasticity, environment shaping, and environment tracking. These strategies share similarities in their utilization of adaptive and self-organization processes that are not well appreciated yet might be suggestive of reusable building blocks for generating robust behavior. PMID:22593762

  12. Robust Multiobjective Controllability of Complex Neuronal Networks.

    PubMed

    Tang, Yang; Gao, Huijun; Du, Wei; Lu, Jianquan; Vasilakos, Athanasios V; Kurths, Jurgen

    2016-01-01

    This paper addresses robust multiobjective identification of driver nodes in the neuronal network of a cat's brain, in which uncertainties in determination of driver nodes and control gains are considered. A framework for robust multiobjective controllability is proposed by introducing interval uncertainties and optimization algorithms. By appropriate definitions of robust multiobjective controllability, a robust nondominated sorting adaptive differential evolution (NSJaDE) is presented by means of the nondominated sorting mechanism and the adaptive differential evolution (JaDE). The simulation experimental results illustrate the satisfactory performance of NSJaDE for robust multiobjective controllability, in comparison with six statistical methods and two multiobjective evolutionary algorithms (MOEAs): nondominated sorting genetic algorithms II (NSGA-II) and nondominated sorting composite differential evolution. It is revealed that the existence of uncertainties in choosing driver nodes and designing control gains heavily affects the controllability of neuronal networks. We also unveil that driver nodes play a more drastic role than control gains in robust controllability. The developed NSJaDE and obtained results will shed light on the understanding of robustness in controlling realistic complex networks such as transportation networks, power grid networks, biological networks, etc.

  13. Fast and Robust STEM Reconstruction in Complex Environments Using Terrestrial Laser Scanning

    NASA Astrophysics Data System (ADS)

    Wang, D.; Hollaus, M.; Puttonen, E.; Pfeifer, N.

    2016-06-01

    Terrestrial Laser Scanning (TLS) is an effective tool in forest research and management. However, accurate estimation of tree parameters still remains challenging in complex forests. In this paper, we present a novel algorithm for stem modeling in complex environments. This method does not require accurate delineation of stem points from the original point cloud. The stem reconstruction features a self-adaptive cylinder growing scheme. This algorithm is tested for a landslide region in the federal state of Vorarlberg, Austria. The algorithm results are compared with field reference data, which show that our algorithm is able to accurately retrieve the diameter at breast height (DBH) with a root mean square error (RMSE) of ~1.9 cm. This algorithm is further facilitated by applying an advanced sampling technique. Different sampling rates are applied and tested. It is found that a sampling rate of 7.5% is already able to retain the stem fitting quality and simultaneously reduce the computation time significantly by ~88%.

  14. Fast and Robust Reconstruction for Fluorescence Molecular Tomography via L1-2 Regularization

    PubMed Central

    Zhang, Haibo; Wang, Xiaodong; Qu, Xuan; Hou, Yuqing

    2016-01-01

    Sparse reconstruction inspired by compressed sensing has attracted considerable attention in fluorescence molecular tomography (FMT). However, the columns of system matrix used for FMT reconstruction tend to be highly coherent, which means L1 minimization may not produce the sparsest solution. In this paper, we propose a novel reconstruction method by minimization of the difference of L1 and L2 norms. To solve the nonconvex L1-2 minimization problem, an iterative method based on the difference of convex algorithm (DCA) is presented. In each DCA iteration, the update of solution involves an L1 minimization subproblem, which is solved by the alternating direction method of multipliers with an adaptive penalty. We investigated the performance of the proposed method with both simulated data and in vivo experimental data. The results demonstrate that the DCA for L1-2 minimization outperforms the representative algorithms for L1, L2, L1/2, and L0 when the system matrix is highly coherent. PMID:28050563

  15. Elliptical Local Vessel Density: a Fast and Robust Quality Metric for Fundus Images

    SciTech Connect

    Giancardo, Luca; Chaum, Edward; Karnowski, Thomas Paul; Meriaudeau, Fabrice; Tobin Jr, Kenneth William; Abramoff, M.D.

    2008-01-01

    A great effort of the research community is geared towards the creation of an automatic screening system able to promptly detect diabetic retinopathy with the use of fundus cameras. In addition, there are some documented approaches to the problem of automatically judging the image quality. We propose a new set of features independent of Field of View or resolution to describe the morphology of the patient's vessels. Our initial results suggest that they can be used to estimate the image quality in a time one order of magnitude shorter respect to previous techniques.

  16. A Review of Fast L(1)-Minimization Algorithms for Robust Face Recognition

    DTIC Science & Technology

    2010-07-01

    Tucker ( KKT ) station- ary condition for the convex program (Pµ) [36, 32]. Hence, the update rule on the current value (x(k),y(k), z(k)) is defined by...Lagrange multiplier vector satisfying the second-order sufficiency conditions for optimality (see section 3.2 in [8] for more details). Then, for...unconstrained convex optimization problem: x∗ = arg minx F (x) = arg minx 1 2‖b−Ax‖ 2 2 + λ‖x‖1,. = arg minx f(x) + λg(x) (26) where f(x) = 12‖b− Ax‖ 2

  17. A Fast and Robust Approach to Long-Distance Quantum Communication With Atomic Ensembles

    DTIC Science & Technology

    2007-07-01

    m+1 1 2 plogic m plogic m 1 + perr ,new m+1 + Opc , p̃vac m+1 1 2 plogic m pvac m1 + Opc , p̃multi m+1 1 2 plogic m...pmulti m 1 + Opc , where the probability for the new logical error from the mul- tiexcitation states accompanied by photon loss is perr ,new m...1 1 − pc. The total logical error probability perr m+1 has two contribu- tions: the accumulated logical errors from both input pairs for ENC

  18. Advanced Robust STAP Algorithms and Fast Performance Evaluation Techniques Based on Rare Event Theory

    DTIC Science & Technology

    2007-03-27

    matched to the direction s in which the array is steered) for incoherent detection using the so-called sample matrix inversion (SMI) beamformer weights...can be carried out for data possessing a diagonal covariance matrix I, denoting the N ×N identity matrix. Therefore, primary and training data can be...passing that this derivative estimator actually estimates ( negative of) the probability density function of the AMF statistic on the left hand side of

  19. Robust, fast, and effective two-dimensional automatic phase unwrapping algorithm based on image decomposition.

    PubMed

    Herráez, Miguel Arevallilo; Gdeisat, Munther A; Burton, David R; Lalor, Michael J

    2002-12-10

    We describe what is to our knowledge a novel approach to phase unwrapping. Using the principle of unwrapping following areas with similar phase values (homogenous areas), the algorithm reacts satisfactorily to random noise and breaks in the wrap distributions. Execution times for a 512 x 512 pixel phase distribution are in the order of a half second on a desktop computer. The precise value depends upon the particular image under analysis. Two inherent parameters allow tuning of the algorithm to images of different quality and nature.

  20. Fast and robust image segmentation by small-world neural oscillator networks.

    PubMed

    Li, Chunguang; Li, Yuke

    2011-06-01

    Inspired by the temporal correlation theory of brain functions, researchers have presented a number of neural oscillator networks to implement visual scene segmentation problems. Recently, it is shown that many biological neural networks are typical small-world networks. In this paper, we propose and investigate two small-world models derived from the well-known LEGION (locally excitatory and globally inhibitory oscillator network) model. To form a small-world network, we add a proper proportion of unidirectional shortcuts (random long-range connections) to the original LEGION model. With local connections and shortcuts, the neural oscillators can not only communicate with neighbors but also exchange phase information with remote partners. Model 1 introduces excitatory shortcuts to enhance the synchronization within an oscillator group representing the same object. Model 2 goes further to replace the global inhibitor with a sparse set of inhibitory shortcuts. Simulation results indicate that the proposed small-world models could achieve synchronization faster than the original LEGION model and are more likely to bind disconnected image regions belonging together. In addition, we argue that these two models are more biologically plausible.

  1. Fast Adaptive Least Trimmed Squares for Robust Evaluation of Quality of Experience

    DTIC Science & Technology

    2014-07-01

    Uniform, Thurstone - Mosteller, Bradley-Terry, and Angular Transform), but also measures the inconsistency of the global ranking obtained. The...Ed. Yale University Press, New Haven, CT, 1963. [25] L. Thurstone , “A law of comparative judgement,” Psychological Review, vol. 34, pp. 278–286, 1927

  2. Fast and Robust Sixth Order Multigrid Computation for 3D Convection Diffusion Equation

    PubMed Central

    Wang, Yin; Zhang, Jun

    2010-01-01

    We present a sixth order explicit compact finite difference scheme to solve the three dimensional (3D) convection diffusion equation. We first use multiscale multigrid method to solve the linear systems arising from a 19-point fourth order discretization scheme to compute the fourth order solutions on both the coarse grid and the fine grid. Then an operator based interpolation scheme combined with an extrapolation technique is used to approximate the sixth order accurate solution on the fine grid. Since the multigrid method using a standard point relaxation smoother may fail to achieve the optimal grid independent convergence rate for solving convection diffusion equation with a high Reynolds number, we implement the plane relaxation smoother in the multigrid solver to achieve better grid independency. Supporting numerical results are presented to demonstrate the efficiency and accuracy of the sixth order compact scheme (SOC), compared with the previously published fourth order compact scheme (FOC). PMID:21151737

  3. Fast and robust segmentation of solar EUV images: algorithm and results for solar cycle 23

    NASA Astrophysics Data System (ADS)

    Barra, V.; Delouille, V.; Kretzschmar, M.; Hochedez, J.-F.

    2009-10-01

    Context: The study of the variability of the solar corona and the monitoring of coronal holes, quiet sun and active regions are of great importance in astrophysics as well as for space weather and space climate applications. Aims: In a previous work, we presented the spatial possibilistic clustering algorithm (SPoCA). This is a multi-channel unsupervised spatially-constrained fuzzy clustering method that automatically segments solar extreme ultraviolet (EUV) images into regions of interest. The results we reported on SoHO-EIT images taken from February 1997 to May 2005 were consistent with previous knowledge in terms of both areas and intensity estimations. However, they presented some artifacts due to the method itself. Methods: Herein, we propose a new algorithm, based on SPoCA, that removes these artifacts. We focus on two points: the definition of an optimal clustering with respect to the regions of interest, and the accurate definition of the cluster edges. We moreover propose methodological extensions to this method, and we illustrate these extensions with the automatic tracking of active regions. Results: The much improved algorithm can decompose the whole set of EIT solar images over the 23rd solar cycle into regions that can clearly be identified as quiet sun, coronal hole and active region. The variations of the parameters resulting from the segmentation, i.e. the area, mean intensity, and relative contribution to the solar irradiance, are consistent with previous results and thus validate the decomposition. Furthermore, we find indications for a small variation of the mean intensity of each region in correlation with the solar cycle. Conclusions: The method is generic enough to allow the introduction of other channels or data. New applications are now expected, e.g. related to SDO-AIA data.

  4. Fast Traffic Sign Recognition with a Rotation Invariant Binary Pattern Based Feature

    PubMed Central

    Yin, Shouyi; Ouyang, Peng; Liu, Leibo; Guo, Yike; Wei, Shaojun

    2015-01-01

    Robust and fast traffic sign recognition is very important but difficult for safe driving assistance systems. This study addresses fast and robust traffic sign recognition to enhance driving safety. The proposed method includes three stages. First, a typical Hough transformation is adopted to implement coarse-grained location of the candidate regions of traffic signs. Second, a RIBP (Rotation Invariant Binary Pattern) based feature in the affine and Gaussian space is proposed to reduce the time of traffic sign detection and achieve robust traffic sign detection in terms of scale, rotation, and illumination. Third, the techniques of ANN (Artificial Neutral Network) based feature dimension reduction and classification are designed to reduce the traffic sign recognition time. Compared with the current work, the experimental results in the public datasets show that this work achieves robustness in traffic sign recognition with comparable recognition accuracy and faster processing speed, including training speed and recognition speed. PMID:25608217

  5. Fast traffic sign recognition with a rotation invariant binary pattern based feature.

    PubMed

    Yin, Shouyi; Ouyang, Peng; Liu, Leibo; Guo, Yike; Wei, Shaojun

    2015-01-19

    Robust and fast traffic sign recognition is very important but difficult for safe driving assistance systems. This study addresses fast and robust traffic sign recognition to enhance driving safety. The proposed method includes three stages. First, a typical Hough transformation is adopted to implement coarse-grained location of the candidate regions of traffic signs. Second, a RIBP (Rotation Invariant Binary Pattern) based feature in the affine and Gaussian space is proposed to reduce the time of traffic sign detection and achieve robust traffic sign detection in terms of scale, rotation, and illumination. Third, the techniques of ANN (Artificial Neutral Network) based feature dimension reduction and classification are designed to reduce the traffic sign recognition time. Compared with the current work, the experimental results in the public datasets show that this work achieves robustness in traffic sign recognition with comparable recognition accuracy and faster processing speed, including training speed and recognition speed.

  6. Community health workers in rural India: analysing the opportunities and challenges Accredited Social Health Activists (ASHAs) face in realising their multiple roles.

    PubMed

    Saprii, Lipekho; Richards, Esther; Kokho, Puni; Theobald, Sally

    2015-12-09

    Globally, there is increasing interest in community health worker's (CHW) performance; however, there are gaps in the evidence with respect to CHWs' role in community participation and empowerment. Accredited Social Health Activists (ASHAs), whose roles include social activism, are the key cadre in India's CHW programme which is designed to improve maternal and child health. In a diverse country like India, there is a need to understand how the ASHA programme operates in different underserved Indian contexts, such as rural Manipur. We undertook qualitative research to explore stakeholders' perceptions and experiences of the ASHA scheme in strengthening maternal health and uncover the opportunities and challenges ASHAs face in realising their multiple roles in rural Manipur, India. Data was collected through in-depth interviews (n = 18) and focus group discussions (n = 3 FGDs, 18 participants). Participants included ASHAs, key stakeholders and community members. They were purposively sampled based on remoteness of villages and primary health centres to capture diverse and relevant constituencies, as we believed experiences of ASHAs can be shaped by remoteness. Data were analysed using the thematic framework approach. Findings suggested that ASHAs are mostly understood as link workers. ASHA's ability to address the immediate needs of rural and marginalised communities meant that they were valued as service providers. The programme is perceived to be beneficial as it improves awareness and behaviour change towards maternal care. However, there are a number of challenges; the selection of ASHAs is influenced by power structures and poor community sensitisation of the ASHA programme presents a major risk to success and sustainability. The primary health centres which ASHAs link to are ill-equipped. Thus, ASHAs experience adverse consequences in their ability to inspire trust and credibility in the community. Small and irregular monetary incentives demotivate

  7. Robust adaptive backstepping control for reentry reusable launch vehicles

    NASA Astrophysics Data System (ADS)

    Wang, Zhen; Wu, Zhong; Du, Yijiang

    2016-09-01

    During the reentry process of reusable launch vehicles (RLVs), the large range of flight envelope will not only result in high nonlinearities, strong coupling and fast time-varying characteristics of the attitude dynamics, but also result in great uncertainties in the atmospheric density, aerodynamic coefficients and environmental disturbances, etc. In order to attenuate the effects of these problems on the control performance of the reentry process, a robust adaptive backstepping control (RABC) strategy is proposed for RLV in this paper. This strategy consists of two-loop controllers designed via backstepping method. Both the outer and the inner loop adopt a robust adaptive controller, which can deal with the disturbances and uncertainties by the variable-structure term with the estimation of their bounds. The outer loop can track the desired attitude by the design of virtual control-the desired angular velocity, while the inner one can track the desired angular velocity by the design of control torque. Theoretical analysis indicates that the closed-loop system under the proposed control strategy is globally asymptotically stable. Even if the boundaries of the disturbances and uncertainties are unknown, the attitude can track the desired value accurately. Simulation results of a certain RLV demonstrate the effectiveness of the control strategy.

  8. Unsupervised, Robust Estimation-based Clustering for Multispectral Images

    NASA Technical Reports Server (NTRS)

    Netanyahu, Nathan S.

    1997-01-01

    To prepare for the challenge of handling the archiving and querying of terabyte-sized scientific spatial databases, the NASA Goddard Space Flight Center's Applied Information Sciences Branch (AISB, Code 935) developed a number of characterization algorithms that rely on supervised clustering techniques. The research reported upon here has been aimed at continuing the evolution of some of these supervised techniques, namely the neural network and decision tree-based classifiers, plus extending the approach to incorporating unsupervised clustering algorithms, such as those based on robust estimation (RE) techniques. The algorithms developed under this task should be suited for use by the Intelligent Information Fusion System (IIFS) metadata extraction modules, and as such these algorithms must be fast, robust, and anytime in nature. Finally, so that the planner/schedule module of the IlFS can oversee the use and execution of these algorithms, all information required by the planner/scheduler must be provided to the IIFS development team to ensure the timely integration of these algorithms into the overall system.

  9. Robust visual tracking with dual spatio-temporal context trackers

    NASA Astrophysics Data System (ADS)

    Sun, Shiyan; Zhang, Hong; Yuan, Ding

    2015-12-01

    Visual tracking is a challenging problem in computer vision. Recent years, significant numbers of trackers have been proposed. Among these trackers, tracking with dense spatio-temporal context has been proved to be an efficient and accurate method. Other than trackers with online trained classifier that struggle to meet the requirement of real-time tracking task, a tracker with spatio-temporal context can run at hundreds of frames per second with Fast Fourier Transform (FFT). Nevertheless, the performance of the tracker with Spatio-temporal context relies heavily on the learning rate of the context, which restricts the robustness of the tracker. In this paper, we proposed a tracking method with dual spatio-temporal context trackers that hold different learning rate during tracking. The tracker with high learning rate could track the target smoothly when the appearance of target changes, while the tracker with low learning rate could percepts the occlusion occurring and continues to track when the target starts to emerge again. To find the target among the candidates from these two trackers, we adopt Normalized Correlation Coefficient (NCC) to evaluate the confidence of each sample. Experimental results show that the proposed algorithm performs robustly against several state-of-the-art tracking methods.

  10. TsuPy: Computational robustness in Tsunami hazard modelling

    NASA Astrophysics Data System (ADS)

    Schäfer, Andreas M.; Wenzel, Friedemann

    2017-05-01

    Modelling wave propagation is the most essential part in assessing the risk and hazard of tsunami and storm surge events. For the computational assessment of the variability of such events, many simulations are necessary. Even today, most of these simulations are generally run on supercomputers due to the large amount of computations necessary. In this study, a simulation framework, named TsuPy, is introduced to quickly compute tsunami events on a personal computer. It uses the parallelized power of GPUs to accelerate computation. The system is tailored to the application of robust tsunami hazard and risk modelling. It links up to geophysical models to simulate event sources. The system is tested and validated using various benchmarks and real-world case studies. In addition, the robustness criterion is assessed based on a sensitivity study comparing the error impact of various model elements e.g. of topo-bathymetric resolution, knowledge of Manning friction parameters and the knowledge of the tsunami source itself. This sensitivity study is tested on inundation modelling of the 2011 Tohoku tsunami, showing that the major contributor to model uncertainty is in fact the representation of earthquake slip as part of the tsunami source profile. TsuPy provides a fast and reliable tool to quickly assess ocean hazards from tsunamis and thus builds the foundation for a globally uniform hazard and risk assessment for tsunamis.

  11. Cascading failure and robustness in metabolic networks.

    PubMed

    Smart, Ashley G; Amaral, Luis A N; Ottino, Julio M

    2008-09-09

    We investigate the relationship between structure and robustness in the metabolic networks of Escherichia coli, Methanosarcina barkeri, Staphylococcus aureus, and Saccharomyces cerevisiae, using a cascading failure model based on a topological flux balance criterion. We find that, compared to appropriate null models, the metabolic networks are exceptionally robust. Furthermore, by decomposing each network into rigid clusters and branched metabolites, we demonstrate that the enhanced robustness is related to the organization of branched metabolites, as rigid cluster formations in the metabolic networks appear to be consistent with null model behavior. Finally, we show that cascading in the metabolic networks can be described as a percolation process.

  12. Robustness and structure of complex networks

    NASA Astrophysics Data System (ADS)

    Shao, Shuai

    This dissertation covers the two major parts of my PhD research on statistical physics and complex networks: i) modeling a new type of attack -- localized attack, and investigating robustness of complex networks under this type of attack; ii) discovering the clustering structure in complex networks and its influence on the robustness of coupled networks. Complex networks appear in every aspect of our daily life and are widely studied in Physics, Mathematics, Biology, and Computer Science. One important property of complex networks is their robustness under attacks, which depends crucially on the nature of attacks and the structure of the networks themselves. Previous studies have focused on two types of attack: random attack and targeted attack, which, however, are insufficient to describe many real-world damages. Here we propose a new type of attack -- localized attack, and study the robustness of complex networks under this type of attack, both analytically and via simulation. On the other hand, we also study the clustering structure in the network, and its influence on the robustness of a complex network system. In the first part, we propose a theoretical framework to study the robustness of complex networks under localized attack based on percolation theory and generating function method. We investigate the percolation properties, including the critical threshold of the phase transition pc and the size of the giant component Pinfinity. We compare localized attack with random attack and find that while random regular (RR) networks are more robust against localized attack, Erdoḧs-Renyi (ER) networks are equally robust under both types of attacks. As for scale-free (SF) networks, their robustness depends crucially on the degree exponent lambda. The simulation results show perfect agreement with theoretical predictions. We also test our model on two real-world networks: a peer-to-peer computer network and an airline network, and find that the real-world networks

  13. Robust stability of second-order systems

    NASA Technical Reports Server (NTRS)

    Chuang, C. H.

    1993-01-01

    This report presents a robust control design using strictly positive realness for second-order dynamic systems. The robust strictly positive real controller allows the system to be stabilized with only acceleration measurements. An important property of this design is that stabilization of the system is independent of the system parameters. The control design connects a virtual system to the given plant. The combined system is positive real regardless of system parameter uncertainty. Then any strictly positive real controllers can be used to achieve robust stability. A spring-mass system example and its computer simulations are presented to demonstrate this controller design.

  14. Modeling and robust control of wind turbine

    NASA Astrophysics Data System (ADS)

    Gilev, Bogdan

    2016-12-01

    In this paper a model of a wind turbine is evaluated, consisting of: wind speed model, mechanical and electrical model of generator and tower oscillation model. This model is linearized around of a nominal point. By using the linear model with uncertainties is synthesized a uncertain model. By using the uncertain model and robust control theory is developed a robust controller, which provide mode of stabilizing the rotor frequency and damping the tower oscillations. Finally is simulated work of nonlinear system and robust controller

  15. Qualitative Robustness for General Stochastic Processes.

    DTIC Science & Technology

    1982-10-01

    and weak pointvise robustness are equivalent. The following proposition gives a necessary and sufficient condition for strong pointwise robustness... Proposition 4.1.(T ) is strongly pointwise robust at if liven. 0 c > 0, there exists 6 > 0 such that n(4.1) r) X (E I Snf(zX )>~1 C. Proof. Let Au(x EXr...function of x~ and (c) Sis stationary and eraodic. Then (T) is strongly pointwise ro- proof. By Proposition 4.lis enough to prove that given C > 0

  16. Cascading failure and robustness in metabolic networks

    PubMed Central

    Smart, Ashley G.; Amaral, Luis A. N.; Ottino, Julio M.

    2008-01-01

    We investigate the relationship between structure and robustness in the metabolic networks of Escherichia coli, Methanosarcina barkeri, Staphylococcus aureus, and Saccharomyces cerevisiae, using a cascading failure model based on a topological flux balance criterion. We find that, compared to appropriate null models, the metabolic networks are exceptionally robust. Furthermore, by decomposing each network into rigid clusters and branched metabolites, we demonstrate that the enhanced robustness is related to the organization of branched metabolites, as rigid cluster formations in the metabolic networks appear to be consistent with null model behavior. Finally, we show that cascading in the metabolic networks can be described as a percolation process. PMID:18765805

  17. Redundancy relations and robust failure detection

    NASA Technical Reports Server (NTRS)

    Chow, E. Y.; Lou, X. C.; Verghese, G. C.; Willsky, A. S.

    1984-01-01

    All failure detection methods are based on the use of redundancy, that is on (possible dynamic) relations among the measured variables. Consequently the robustness of the failure detection process depends to a great degree on the reliability of the redundancy relations given the inevitable presence of model uncertainties. The problem of determining redundancy relations which are optimally robust in a sense which includes the major issues of importance in practical failure detection is addressed. A significant amount of intuition concerning the geometry of robust failure detection is provided.

  18. The Rotated Speeded-Up Robust Features Algorithm (R-SURF) (CD-ROM)

    DTIC Science & Technology

    Weaknesses in the Fast Hessian detector utilized by the speeded-up robust features ( SURF ) algorithm are examined in this research. We evaluate the SURF ...algorithm to identify possible areas for improvement in the performance. A proposed alternative to the SURF detector is proposed called rotated SURF (R- SURF ...against the regular SURF detector. Performance testing shows that the R- SURF outperforms the regular SURF detector when subject to image blurring

  19. Fast Ignitor coupling physics

    SciTech Connect

    Mason, R.J.; Tabak, M.

    1997-10-01

    The Fast Ignitor is an alternate approach to ICF in which short pulse lasers are used to initiate burn at the surface of the compressed DT fuel. The aim is to avoid the need for careful central focusing of final shocks, and possibly to lower substantially the energy requirements for ignition. Ultimately, both goals may prove crucial to Science Based Stockpile Stewardship (SBSS). This will be the case should either emerging energetic needs, or finding difficulties render the presently planned radiative fusion approach to ignition with the NIF impractical. Ignition is a first step towards the achievement of substantial energy and neutron outputs for such Stewardship.

  20. Simplified fast neutron dosimeter

    DOEpatents

    Sohrabi, Mehdi

    1979-01-01

    Direct fast-neutron-induced recoil and alpha particle tracks in polycarbonate films may be enlarged for direct visual observation and automated counting procedures employing electrochemical etching techniques. Electrochemical etching is, for example, carried out in a 28% KOH solution at room temperature by applying a 2000 V peak-to-peak voltage at 1 kHz frequency. Such recoil particle amplification can be used for the detection of wide neutron dose ranges from 1 mrad. to 1000 rads. or higher, if desired.