The Preliminary Personnel Data Base Design for the Indonesian Navy.

DTIC Science & Technology

1982-06-01

external, which influence the * validity and success of this planning. Internal factors include all the problems which relate to the personnel sys - ton...the SIP-TNI-AL (Navy MIS) [Ref. 10], sys - *l tea’s users include the following: 1. Headquarters level: a) Manager level, b) Staff level, c) Central...Angeles: universTy -| ofcalizoara, April 1970. 10. Nabes TNI-AL ZiIT1a 11. Malone Joh S and Robert P. Thor of he Hhi!brator esearch Report SRR7

Relationship Between Job Satisfaction and Career Intent of D.P. Personnel in the Korean Military E.D.P. System.

DTIC Science & Technology

1980-03-01

sincere appreciation to those persons who have been always around me in my mind and in their mind. I wish to thank my thesis advisor, Professor Charles W...different environments. Individual behavior in organizations is a function of the person and of his or her environmental situation (Ref 3:217). The...satisfaction is defined by Robert Hoppock as follows: "Any combination of psychological, physiological, and environmental circumstances that causes a person

Featured Image: The Simulated Collapse of a Core

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-11-01

This stunning snapshot (click for a closer look!) is from a simulation of a core-collapse supernova. Despite having been studied for many decades, the mechanism driving the explosions of core-collapse supernovae is still an area of active research. Extremely complex simulations such as this one represent best efforts to include as many realistic physical processes as is currently computationally feasible. In this study led by Luke Roberts (a NASA Einstein Postdoctoral Fellow at Caltech at the time), a core-collapse supernova is modeled long-term in fully 3D simulations that include the effects of general relativity, radiation hydrodynamics, and even neutrino physics. The authors use these simulations to examine the evolution of a supernova after its core bounce. To read more about the teams findings (and see more awesome images from their simulations), check out the paper below!CitationLuke F. Roberts et al 2016 ApJ 831 98. doi:10.3847/0004-637X/831/1/98

Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1).

PubMed

Laev, Sergey S; Salakhutdinov, Nariman F; Lavrik, Olga I

2017-05-01

Human apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein which is essential in the base excision repair (BER) pathway of DNA lesions caused by oxidation and alkylation. This protein hydrolyzes DNA adjacent to the 5'-end of an apurinic/apyrimidinic (AP) site to produce a nick with a 3'-hydroxyl group and a 5'-deoxyribose phosphate moiety or activates the DNA-binding activity of certain transcription factors through its redox function. Studies have indicated a role for APE1/Ref-1 in the pathogenesis of cancer and in resistance to DNA-interactive drugs. Thus, this protein has potential as a target in cancer treatment. As a result, major efforts have been directed to identify small molecule inhibitors against APE1/Ref-1 activities. These agents have the potential to become anticancer drugs. The aim of this review is to present recent progress in studies of all published small molecule APE1/Ref-1 inhibitors. The structures and activities of APE1/Ref-1 inhibitors, that target both DNA repair and redox activities, are presented and discussed. To date, there is an urgent need for further development of the design and synthesis of APE1/Ref-1 inhibitors due to high importance of this protein target. Copyright © 2017 Elsevier Ltd. All rights reserved.

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

PubMed

Mole, Damian J; Webster, Scott P; Uings, Iain; Zheng, Xiaozhong; Binnie, Margaret; Wilson, Kris; Hutchinson, Jonathan P; Mirguet, Olivier; Walker, Ann; Beaufils, Benjamin; Ancellin, Nicolas; Trottet, Lionel; Bénéton, Véronique; Mowat, Christopher G; Wilkinson, Martin; Rowland, Paul; Haslam, Carl; McBride, Andrew; Homer, Natalie Z M; Baily, James E; Sharp, Matthew G F; Garden, O James; Hughes, Jeremy; Howie, Sarah E M; Holmes, Duncan S; Liddle, John; Iredale, John P

2016-02-01

Acute pancreatitis (AP) is a common and devastating inflammatory condition of the pancreas that is considered to be a paradigm of sterile inflammation leading to systemic multiple organ dysfunction syndrome (MODS) and death. Acute mortality from AP-MODS exceeds 20% (ref. 3), and the lifespans of those who survive the initial episode are typically shorter than those of the general population. There are no specific therapies available to protect individuals from AP-MODS. Here we show that kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism, is central to the pathogenesis of AP-MODS. We created a mouse strain that is deficient for Kmo (encoding KMO) and that has a robust biochemical phenotype that protects against extrapancreatic tissue injury to the lung, kidney and liver in experimental AP-MODS. A medicinal chemistry strategy based on modifications of the kynurenine substrate led to the discovery of the oxazolidinone GSK180 as a potent and specific inhibitor of KMO. The binding mode of the inhibitor in the active site was confirmed by X-ray co-crystallography at 3.2 Å resolution. Treatment with GSK180 resulted in rapid changes in the levels of kynurenine pathway metabolites in vivo, and it afforded therapeutic protection against MODS in a rat model of AP. Our findings establish KMO inhibition as a novel therapeutic strategy in the treatment of AP-MODS, and they open up a new area for drug discovery in critical illness.

Holocene paleoenviroments of northwest Iowa

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, R.G.; Bettis, E.A. III; Schwert, D.P.

1996-05-01

This paper presents the biotic, sedimentary, geomorphic, and climatic history of the upper part of the Roberts Creek Basin, northeastern Iowa for the late-glacial and Holocene, and compares these records with a C-O isotopic sequence from Coldwater Cave, 60 km northwest of Roberts Creek. the biotic record (pollen, vascular plant and bryophyte macrofossils, and insects) is preserved in floodplain alluvium that underlies three constructional surfaces separated by low scarps. Each surface is underlain by a lithologically and temporally distinct alluvial fill. The highest surface is underlain by the Gunder Member of the Deforest Formation, dating from 11,000 to 4000 yrmore » BP; beneath the intermediate level is the Roberts Creek Member, dating from 4000 to 400 yr BP; and the lowest level is underlain by the Camp Creek Member, deposited during the last 380 yr. Pollen and plant macrofossils in the alluvial fill show that a typical late-glacial spruce forest was replaced by Quercus and Ulmus in the early Holocene. This early-to-middle Holocene forest became dominated by medic elements such as Acer saccharum, Tila americana, Ostyra virginiana, and Carpinus caroliniana as late as 5500 yr BP; in contrast, the closest sites to the west and north were at their warmest and driest were covered by prairie vegetation between 6500 and 5500 yr BP. After 5500 yr BP, the forest in the roberts Creek area was replaced by prairie, as indicated by a rich assemblage of plant macrofossils, although only Ambrosia and Poaceae became abundant in the pollen record. The return of Quercus {approx} 3000 BP (while nonarboreal pollen percentages remained relatively high) indicates the oak savanna prevailed with little change until settlement time. 83 refs., 17 figs., 5 tabs.« less

Isolation of a small molecule inhibitor of DNA base excision repair

PubMed Central

Madhusudan, Srinivasan; Smart, Fiona; Shrimpton, Paul; Parsons, Jason L.; Gardiner, Laurence; Houlbrook, Sue; Talbot, Denis C.; Hammonds, Timothy; Freemont, Paul A.; Sternberg, Michael J. E.; Dianov, Grigory L.; Hickson, Ian D.

2005-01-01

The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. The major AP endonuclease in human cells (APE1, also termed HAP1 and Ref-1) accounts for >95% of the total AP endonuclease activity, and is essential for the protection of cells against the toxic effects of several classes of DNA damaging agents. Moreover, APE1 overexpression has been linked to radio- and chemo-resistance in human tumors. Using a newly developed high-throughput screen, several chemical inhibitors of APE1 have been isolated. Amongst these, CRT0044876 was identified as a potent and selective APE1 inhibitor. CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1 at low micromolar concentrations, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds. This enhancement of cytotoxicity is associated with an accumulation of unrepaired AP sites. In silico modeling studies suggest that CRT0044876 binds to the active site of APE1. These studies provide both a novel reagent for probing APE1 function in human cells, and a rational basis for the development of APE1-targeting drugs for antitumor therapy. PMID:16113242

40 CFR Appendix A to Subpart E of... - Interim Transmission Electron Microscopy Analytical Methods-Mandatory and Nonmandatory-and...

Code of Federal Regulations, 2011 CFR

2011-07-01

... representative of the air entering the abatement site. c. Two field blanks are to be taken by removing the cap... of Sample Data Quality Objectives is shown in the following Table II: EC01AP92.003 C. Sample Shipment... or the Burdette procedure (Ref. 7 of Unit II.J.) ii. Plasma etching of the collapsed filter is...

40 CFR Appendix A to Subpart E of... - Interim Transmission Electron Microscopy Analytical Methods-Mandatory and Nonmandatory-and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representative of the air entering the abatement site. c. Two field blanks are to be taken by removing the cap... of Sample Data Quality Objectives is shown in the following Table II: EC01AP92.003 C. Sample Shipment... or the Burdette procedure (Ref. 7 of Unit II.J.) ii. Plasma etching of the collapsed filter is...

PREFACE: Second Meeting of the APS Topical Group on Hadronic Physics

NASA Astrophysics Data System (ADS)

Ernst, David; de Jager, Kees; Roberts, Craig; Sheldon, Paul; Swanson, Eric

2007-06-01

The Second Meeting of the APS Topical Group on Hadronic Physics was held on 22-24 October 2006 at the Opryland Resort in Nashville, Tennessee. Keeping with tradition, the meeting was held in conjunction with the Fall meeting of the APS Division of Nuclear Physics. Approximately 90 physicists participated in the meeting, presenting 25 talks in seven plenary sessions and 48 talks in 11 parallel sessions. These sessions covered a wide range of topics related to strongly interacting matter. Among these were charm spectroscopy, gluonic exotics, nucleon resonance physics, RHIC physics, electroweak and spin physics, lattice QCD initiatives, and new facilities. Brad Tippens and Brad Keister provided perspective from the funding agencies. The organisers are extremely grateful to the following institutions for financial and logistical support: the American Physical Society, Jefferson Lab, Brookhaven National Laboratory, and Vanderbilt University. We thank the following persons for assisting in organising the parallel sessions: Ted Barnes, Jian-Ping Chen, Ed Kinney, Krishna Kumar, Harry Lee, Mike Leitch, Kam Seth, and Dennis Weygand. We also thank Gerald Ragghianti for designing the conference poster, Will Johns for managing the audio-visual equipment and for placing the talks on the web, Sandy Childress for administrative expertise, and Vanderbilt graduate students Eduardo Luiggi and Jesus Escamillad for their assistance. David Ernst, Kees de Jager, Craig Roberts (Chair), Paul Sheldon and Eric Swanson Editors

Apelin-13 increased food intake with serum ghrelin and leptin levels in male rats.

PubMed

Saral, S; Alkanat, M; Sumer, A; Canpolat, S

2018-01-01

In this study, we aimed to explain the role of apelin-13 on body weight, food and water intake with serum leptin, ghrelin, neuropeptid Y (NPY) and peptid YY (PYY) levels in male rat. Thirty-two Sprague-Dawley male rats were used for the study. The rats were injected SP (0.9 %) intraperitoneally (i.p) in the control group and 30 (AP30), 100 (AP100) and 300 (AP300) µg/kg apelin-13 in the study groups, respectively, 10 min before the transition to dark period, for 10 days. During the experimental period, with light and dark periods of food and water intake, body weights were recorded in rats. Rats were euthanized and serum samples were obtained. In serum samples leptin, ghrelin, NPY and PYY levels were measured with specific ELISA kit. Apelin-13 was increased body weights in all three (AP30, AP100 and AP300) groups compared with the control group. AP100 and AP300 groups had increased food intake in the dark and the cumulative period, but in the light period food intake values were not significantly increased (p > 0.05). As for the value of water intake, compared with the control group, all dose of apelin-13 increased water intake during the dark and the cumulative period. There was no significant change in water intake in the light period. On the other hand, compared with the control group, serum leptin levels were found to increase in the groups administered 100 and 300 µg/kg of apelin-13 (p < 0.05). Ghrelin levels were found high in all groups treated with apelin-13. Serum levels of NPY decreased only in the 300 µg/kg apelin-13 treated group (p 0.05). Apelin-13 increases body weight in rats as well as food and water intake (dark and cumulative period). Additionally, ghrelin can mediate the orexigenic effect of apelin-13 in the regulation of food intake (Fig. 4, Ref. 37).

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Air Products and Chemicals (AP) is looking for buyers for its 50% stake in American Refuel, its waste-to-energy venture with Browning-Ferris. The company also announced plans to buy back 10% of its stock and says it will use the proceeds of the divestiture to partially fund the repurchase. The company declines to estimate the value of its stake in American Ref-Fuel, which runs four waste-to-energy plants. AP says the business is profitable but that it wants to focus on its industrial gases and chemical businesses. Meanwhile, AP CEO H.A. Wagner issued a caution over the company`s second-quarter results, due outmore » later this month. {open_quotes}While we expect our financial performance in the second quarter to be in the range of current analyst estimates, operating income in our gases segment remains at a level similar to that of the most recent quarter. Improving results in this area continues to be management`s top priority,{close_quotes} he says. Operating income for the gases business was down 5% in the first quarter compared with the year earlier.« less

Conference Committees: Conference Committees

NASA Astrophysics Data System (ADS)

2009-09-01

International Programm Committee (IPC) Harald Ade NCSU Sadao Aoki University Tsukuba David Attwood Lawrence Berkeley National Laboratory/CXRO Christian David Paul Scherrer Institut Peter Fischer Lawrence Berkeley National Laboratory Adam Hitchcock McMaster University Chris Jacobsen SUNY, Stony Brook Denis Joyeux Lab Charles Fabry de l'Institut d'Optique Yasushi Kagoshima University of Hyogo Hiroshi Kihara Kansai Medical University Janos Kirz SUNY Stony Brook Maya Kiskinova ELETTRA Ian McNulty Argonne National Lab/APS Alan Michette Kings College London Graeme Morrison Kings College London Keith Nugent University of Melbourne Zhu Peiping BSRF Institute of High Energy Physics Francois Polack Soleil Christoph Quitmann Paul Scherrer Institut Günther Schmahl University Göttingen Gerd Schneider Bessy Hyun-Joon Shin Pohang Accelerator Lab Jean Susini ESRF Mau-Tsu Tang NSRRC Tony Warwick Lawrence Berkeley Lab/ALS Local Organizing Committee Christoph Quitmann Chair, Scientific Program Charlotte Heer Secretary Christian David Scientific Program Frithjof Nolting Scientific Program Franz Pfeiffer Scientific Program Marco Stampanoni Scientific Program Robert Rudolph Sponsoring, Financials Alfred Waser Industry Exhibition Robert Keller Public Relation Markus Knecht Computing and WWW Annick Cavedon Proceedings and Excursions and Accompanying Persons Program Margrit Eichler Excursions and Accompanying Persons Program Kathy Eikenberry Excursions and Accompanying Persons Program Marlies Locher Excursions and Accompanying Persons Program

Erratum: The Extragalactic Distance Scale Key Project. III. The Discovery of Cepheids and a New Distance to M101 Using the Hubble Space Telescope

NASA Astrophysics Data System (ADS)

Kelson, Daniel D; Illingworth, Garth D.; Freedman, Wendy F.; Graham, John A.; Hill, Robert; Madore, Barry F.; Saha, Abhijit; Stetson, Peter B.; Kennicutt, Robert C., Jr.; Mould, Jeremy R.; Hughes, Shaun M.; Ferrarese, Laura; Phelps, Randy; Turner, Anne; Cook, Kem H.; Ford, Holland; Hoessel, John G.; Huchra, John

1997-03-01

In the paper ``The Extragalactic Distance Scale Key Project. III. The Discovery of Cepheids and a New Distance to M101 Using the Hubble Space Telescope'' by Daniel D. Kelson, Garth D. Illingworth, Wendy F. Freedman, John A. Graham, Robert Hill, Barry F. Madore, Abhijit Saha, Peter B. Stetson, Robert C. Kennicutt, Jr., Jeremy R. Mould, Shaun M. Hughes, Laura Ferrarese, Randy Phelps, Anne Turner, Kem H. Cook, Holland Ford, John G. Hoessel, and John Huchra (ApJ, 463, 26 [1996]), two of the tables are in error. The magnitudes in Tables B1 and B2, in Appendix B, are ordered incorrectly. As a result, the Julian dates are not associated with their correct Cepheid magnitudes. We have now corrected these data, and updated versions of the tables are available on the World Wide Web. The tables are available in ASCII format at our Key Project site (http://www.ipac.caltech.edu/H0kp/) and will appear in volume 7 of the AAS CDROM. PostScript and paper copies are also available from the first author (http://www.ucolick.org/~kelson/H0/home.html or kelson@ucolick.org).

Aluminum nanoparticles burning - still a puzzle?

NASA Astrophysics Data System (ADS)

Gromov, A. A.; Popenko, E. M.

2009-09-01

The experimental data on the aluminum nanopowders (nAl) combustion in oxidizing media (air, propellants AP∗/HTPB†/Al/HMX‡, and energetic compositions) assuming the phenomenon of nitrides formation with the high yield is generalized. In the present work, the nAl produced by electrical explosion of wires was studied. The temperature, burning rate, and radiation were measured at combustion and the actual burning process was recorded by a videocamera. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and chemical analysis were performed on the both initial powders and final condensed products. It was experimentally proved that the combustion process of aluminum nanoparticles was two staged independently of burning conditions in nitrogen-containing media. The formation of nitrides in presence of molecular nitrogen is the determining stage in the particles combustion. A qualitative discussion is given on the kinetic limitation for AlN (AlON) oxidation due to rapid condensation and encapsulation of solid AlN (AlON).

Activities and Achievements of the Double Star Committee of the Socié té Astronomique de France

NASA Astrophysics Data System (ADS)

Agati, Jean-Louis; Caille, Sébastien; Debackère, André; Durand, Pierre; Losse, Florent; Manté, René; Mauroy, Florence; Mauroy, Pascal; Morlet, Guy; Pinlou, Claude; Salaman, Maurice; Soulié, Edgar; Thorel, Yvonne; Thorel, Jean-Claude

2007-08-01

In a synthesis article (see ref. below), the double star expert Paul COUTEAU put the work of French pioneers of double stars observation in the perspective of the double star work carried in the world. After Antoine Yvon VILLARCEAU and Camille FLAMMARION, one prominent pioneer of double stars was Robert JONCKHEERE (1888toiles Doubles, Maurice DURUY (1894le with a 40-cm and later a 60-cm telescope at Le Rouret (Alpes1995) had started the measurement of double stars as an amateur. He was granted permission to measure them with the 38-cm of the Paris Observatory and made an impressive number of measures during his long 2006) made double star observations for the book which was then in preparation under the title La revue des constellations. Their measures remained unpublished; but publication of the measures made by Robert SAGOT is in preparation. At about the same time, the neurology professor Jacques LE BEAU (1908toiles doubles visuelles. That book triggered the interest of more amateur astronomers for double stars and indirectly influenced the creation of a group of double star observers which was transformed into the Commission des É toiles Doubles

Inflammation in Prostate Carcinogenesis: Role of the Tumor Suppressor Par-4

DTIC Science & Technology

2012-09-01

2006; 2: 138–139. 112. Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, Contamine D et al. Ref(2)P, the Drosophila melanogaster homologue of...Tommerup N, Hansen C, Vissing H, Shi Y. Mapping of the human PAWR (par-4) gene to chromosome 12q21. Genomics 1998; 53:241-3. 17. Joshi J... The two aPKC isoforms are highly related, sharing an overall amino acid identity of 72%.1 The conservation in their sequences is most striking in the

The Development of an Information System Master Plan for the Pacific Missile Range Facility, Barking Sands, Hawaii

DTIC Science & Technology

1992-03-01

sites and support facilities are located on the islands of Niihau and Oahu. Figure 1 depicts the overall layout of PMRF. [Ref. 4: p. 2] In addition...the HIANG facility at Kokee: • a wideband microwave system serving Niihau Island remotely controls operation of the AN/APS-134 surveillance radar, and...provides relay of digitized radar data, control data and voice between the remotely operated, unmanned radar on Niihau Island and Barking Sands

Molecular analysis of a GM2-activator deficiency in two patients with GM2-gangliosidosis AB variant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schepers, U.; Glombitza, G.; Lemm, T.

1996-11-01

Lysosomal degradation of ganglioside GM2 by {beta}-hexosaminidase A (hex A) requires the presence of the GM2 activator protein (GM2AP) as an essential cofactor. A deficiency of the GM2 activator causes the AB variant of GM2 gangliosidosis, a recessively inherited disorder characterized by excessive neuronal accumulation of GM2 and related glycolipids. Two novel mutations in the GM2 activator gene (GM2A) have been identified by the reverse-transcriptase-PCR method - a three-base deletion, AAG{sup 262-264}, resulting in a deletion of Lys{sup 88}, and a single-base deletion, A{sup 410}, that causes a frameshift. The latter results in substitution of 33 amino acids and themore » loss of another 24 amino acid residues. Both patients are homoallelic for their respective mutations inherited from their parents, who are heteroallelic at the GM2A locus. Although the cultured fibroblasts of both patients produce normal levels of activator mRNA, they lack a lysosomal form of GM2AP. Pulse/chase labeling of cultured fibroblasts of the patients, in presence and absence of brefeldin A, indicates a premature degradation of both-mutant and truncated-GM2APs in the endoplasmic reticulum or Golgi. These results were supported by in vitro translation experiments and expression of the mutated proteins. When the mutated GM2APs were expressed in Escherichia coli, both mature GM2AP forms turned proved to exhibit only residual activities in an in vitro assay. 26 refs., 7 figs.« less

Permeability of ferret trachea in vitro to {sup 99m}{Tc}-DTPA and [{sup 14}C]antipyrine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanafi, Z.; Webber, S.E.; Widdicombe, J.G.

1994-09-01

Platelet-activating factor (PAF) and vasoactive drugs were tested on permeability of ferret trachea in vitro by measuring fluxes of {sup 99m}{Tc}-diethylenetriamine pentaacetic acid ({sup 99m}{Tc}-DTPA; hydrophilic) and [{sup 14}C]antipyrine ([{sup 14}C]AP; lipophilic) across the tracheal wall. Tracheae were bathed on both sides with Krebs-Henseleit buffer, with luminal buffer containing either {sup 99m}{Tc}-DTPA or [{sup 14}C]AP. Luminal and abluminal radioactivities, potential difference, and tracheal smooth muscle tone were measured. Baseline {sup 99m}{Tc}-DTPA and [{sup 14}C]AP permeability coefficients were - 4.7 {+-} 0.6 (SE) x 10{sup {minus}7} and -2.2 {+-} 0.1 x 10{sup {minus}5} cm/s, respectively. PAF (10 {mu}M) increased permeability tomore » {sup 99m}{Tc}-DTPA to -35.3 {+-} 7.6 x 10{sup {minus}7} cm/s (P < 0.05), but permeability to [{sup 14}C]AP did not change, suggesting that paracellular but not transcellular transport was affected. Abluminal and luminal applications of methacholine (MCh, 20 {mu}M), phenylephrine (PE, 100 {mu}M), and albuterol (Alb, 100 {mu}M) caused no change in permeability to {sup 99m}{Tc}-DTPA before or after exposure to luminal PAF, but abluminal histamine (Hist, 10 {mu}M) significantly increased permeability. Abluminal Hist decreased permeability to [{sup 14}C]AP before and after exposure to PAF. MCh, PE, and Hist increased smooth muscle tone; Alb and PAF had no effect. Thus, only PAF and Hist altered permeability to {sup 99m}{Tc}-DTPA, and MCh, PE, and Hist changed smooth muscle tone. Tracheal permeability changes were greater for the hydrophilic than for the lipophilic agent. 37 refs., 11 figs., 1 tab.« less

VizieR Online Data Catalog: 44 SZ-selected galaxy clusters ACT observations (Sifon+, 2016)

NASA Astrophysics Data System (ADS)

Sifon, C.; Battaglia, N.; Hasselfield, M.; Menanteau, F.; Barrientos, L. F.; Bond, J. R.; Crichton, D.; Devlin, M. J.; Dunner, R.; Hilton, M.; Hincks, A. D.; Hlozek, R.; Huffenberger, K. M.; Hughes, J. P.; Infante, L.; Kosowsky, A.; Marsden, D.; Marriage, T. A.; Moodley, K.; Niemack, M. D.; Page, L. A.; Spergel, D. N.; Staggs, S. T.; Trac, H.; Wollack, E. J.

2017-11-01

ACT is a 6-metre off-axis Gregorian telescope located at an altitude of 5200um in the Atacama desert in Chile, designed to observe the CMB at arcminute resolution. Galaxy clusters were detected in the 148GHz band by matched-filtering the maps with the pressure profile suggested by Arnaud et al. (2010A&A...517A..92A), fit to X-ray selected local (z<0.2) clusters, with varying cluster sizes,θ500, from 1.18 to 27-arcmin. Because of the complete overlap of ACT equatorial observations with Sloan Digital Sky Survey Data Release 8 (SDSS DR8; Aihara et al., 2011ApJS..193...29A) imaging, all cluster candidates were assessed with optical data (Menanteau et al., 2013ApJ...765...67M). We observed 20 clusters from the equatorial sample with the Gemini Multi-Object Spectrograph (GMOS) on the Gemini-South telescope, split in semesters 2011B (ObsID:GS-2011B-C-1, PI:Barrientos/Menanteau) and 2012A (ObsID:GS-2012A-C-1, PI:Menanteau), prioritizing clusters in the cosmological sample at 0.3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rybicki, E.F.; Luiskutty, C.T.; Sutrick, J.S.

This research is part of a larger program sponsored by the United States Department of Energy with the objective of developing better methods to produce gas from low permeability formations in western gas sands. This large research program involves several universities and research centers. Each group is involved in a different area of study to answer specific questions. The hydraulic fracturing computer model has three components---a model for fracture geometry, a model for proppant transport, and a computer program that couples the two models. The fracture geometry model was developed at Oral Roberts University and the proppant transport model wasmore » developed at The University of Tulsa prior to the start of the present work. The present work is directed at enhancing the capabilities of these two models and coupling them to obtain a single model for evaluating the final fracture geometry and proppant distribution within the fracture. The report is organized into four parts. Part 1 describes the fracture geometry modeling effort accomplished at Oral Roberts University, NIPER and recently at The University of Tulsa. The proppant transport model, developed for constant height fractures at the University of Tulsa, is contained in Part 2. The coupling of the Proppant Transport Model and the model for the variable height fracture geometry constitutes Part 3 of this report. Part 4 presents a summary of accomplishments and recommendations of this study. 112 refs., 147 figs., 70 tabs.« less

Turbulent Heating and Fluctuation Characteristics in Alfvenic Turbulence

NASA Astrophysics Data System (ADS)

Dorland, William

2005-10-01

Alfve'n waves are ubiquitous in natural and laboratory plasmas. In this talk, the main focus is on astrophysical plasmas that are turbulent, magnetized, hot and diffuse. The dynamically important characteristics of these plasmas are often well- described by magnetohydrodynamics [see e.g., Ref. 1]. However, much of what we actually observe is critically affected by how much of the turbulent energy is absorbed by (highly radiative) electrons [2], the amplitude of density fluctuations [3], and the spectral indices of turbulent, Alfve'nic cascades. These questions each have essentially kinetic aspects. In this talk, we present detailed simulations and analyses of of the cascade of shear Alfve'n waves, to and through scales comparable to the ion Larmor radius in the direction perpendicular to the magnetic field. We demonstrate analytically and numerically that the nonlinear gyrokinetic equations, originally developed for fusion applications, are perfectly suited to these astrophysical problems. We present extensive linear and nonlinear gyrokinetic simulation results from the GS2 code. We demonstrate accurate resolution of the damping of kinetic Alfve'n waves in plasmas with beta small, large and comparable to unity, for a wide range of electron-to-ion temperature ratios, in linear and nonlinear contexts. We have used the GS2 code to calculate the turbulent energy absorption, density fluctuation characteristics, and spectral indices for plasmas with parameters taken from hot accretion flows and from the interstellar plasma. These results will be compared with theoretical predictions [2] and to observations. Co-authors: S. C. Cowley (UCLA), G. W. Hammett (PPPL), E. Quataert and G. Howes (UC-Berkeley), and A. Scheckochihin (Cambridge) 1. S. Balbus and J. Hawley, Rev Mod Phys, Vol. 70, p. 1. 2. E. Quataert and A. Gruzinov, Ap J, Vol. 520, p. 248; E. Quataert, Ap J, Vol. 500, p. 978.3. Y. Lithwick and P. Goldreich, Ap J, Vol. 562, p. 279.4. P. Goldreich and Sridhar, Ap J, Vol. 438, p. 763; P. Goldreich and Sridhar, Ap J, Vol. 485, p. 680.

Intact and Degraded Criticality Calculations for the Codisposal of Shippingport LWBR Spent Nuclear Fuel in a Waste Package

DOE Office of Scientific and Technical Information (OSTI.GOV)

L.M. Montierth

2000-09-15

The objective of this calculation is to characterize the nuclear criticality safety concerns associated with the codisposal of the U.S. Department of Energy's (DOE) Shippingport Light Water Breeder Reactor (SP LWBR) Spent Nuclear Fuel (SNF) in a 5-Defense High-Level Waste (5-DHLW) Waste Package (WP), which is to be placed in a Monitored Geologic Repository (MGR). The scope of this calculation is limited to the determination of the effective neutron multiplication factor (K{sub eff}) for intact- and degraded-mode internal configurations of the codisposal WP containing Shippingport LWBR seed-type assemblies. The results of this calculation will be used to evaluate criticality issuesmore » and support the analysis that is planed to be performed to demonstrate the viability of the codisposal concept for the MGR. This calculation is associated with the waste package design and was performed in accordance with the DOE SNF Analysis Plan for FY 2000 (See Ref. 22). The document has been prepared in accordance with the Administrative Procedure AP-3.12Q, Calculations (Ref. 23).« less

The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) Rev protein, elF-5A, maps to chromosome 17p12-p13: Three elF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steinkasserer, A.; Koettnitz, K.; Hauber, J.

1995-02-10

The eukaryotic initiation factor 5A (eIF-5A) has been identified as an essential cofactor for the HIV-1 transactivator protein Rev. Rev plays a key role in the complex regulation of HIV-1 gene expression and thereby in the generation of infectious virus particles. Expression of eIF-5A is vital for Rev function, and inhibition of this interaction leads to a block of the viral replication cycle. In humans, four different eIF-5A genes have been identified. One codes for the eIF-5A protein and the other three are pseudogenes. Using a panel of somatic rodent-human cell hybrids in combination with fluorescence in situ hybridization analysis,more » we show that the four genes map to three different chromosomes. The coding eIF-5A gene (EIF5A) maps to 17p12-p13, and the three pseudogenes EIF5AP1, EIF5AP2, and EIF5AP3 map to 10q23.3, 17q25, and 19q13.2, respectively. This is the first localization report for a eukaryotic cofactor for a regulatory HIV-1 protein. 16 refs., 1 fig.« less

Constrained signal reconstruction from wavelet transform coefficients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brislawn, C.M.

1991-12-31

A new method is introduced for reconstructing a signal from an incomplete sampling of its Discrete Wavelet Transform (DWT). The algorithm yields a minimum-norm estimate satisfying a priori upper and lower bounds on the signal. The method is based on a finite-dimensional representation theory for minimum-norm estimates of bounded signals developed by R.E. Cole. Cole`s work has its origins in earlier techniques of maximum-entropy spectral estimation due to Lang and McClellan, which were adapted by Steinhardt, Goodrich and Roberts for minimum-norm spectral estimation. Cole`s extension of their work provides a representation for minimum-norm estimates of a class of generalized transformsmore » in terms of general correlation data (not just DFT`s of autocorrelation lags, as in spectral estimation). One virtue of this great generality is that it includes the inverse DWT. 20 refs.« less

Green Bank Telescope Observations of HI in the circumgalactic medium of M31

NASA Astrophysics Data System (ADS)

Denny, Lucas; Early, Laura; Berg, Michelle; Howk, Chris; Lehner, Nicolas; Lockman, Felix; wotta, Christopher

2018-01-01

The nearby spiral galaxy M31 contains an extensive gaseous circumgalactic medium (CGM) that is being studied in project AMIGA, a large HST program to obtain UV spectroscopy of the CGM in absorption against background AGN. As part of this project, sensitive HI 21cm emission observations were made using the Robert C. Byrd Green Bank Telescope (GBT) toward 48 AGN at impact parameters between 25 kpc and 340 kpc. No emission was detected to a 5-sigma limit on log(NHI) of 17.6 cm-2 (Howk et al 2017, ApJ, 846, 141). We now report on a search for HI emission in 1x1 degree fields around 8 of the AGN to 5-sigma limits on log(NHI) of 17.9 cm-2. The new observations cover ~10 times the area of the M31 CGM covered by the Howk et al pointings, though at somewhat reduced sensitivity. Again, no HI emission was detected with the exception of the "Davies Cloud", a high-velocity cloud of M31 that has been known for some time. We will discuss the absence of significant HI emission in the context of the COS-Halos study of 44 galaxies at z~0.2, and how this finding may relate to the existence of HI clouds between M31 and M33 (Wolfe et al. 2016, ApJ, 816, 81).The GBT is a facility of the National Science Foundation, operated under a cooperative agreement by Associated Universities, Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.C. Ryman

This calculation is a revision of a previous calculation (Ref. 7.5) that bears the same title and has the document identifier BBAC00000-01717-0210-00006 REV 01. The purpose of this revision is to remove TBV (to-be-verified) -41 10 associated with the output files of the previous version (Ref. 7.30). The purpose of this and the previous calculation is to generate source terms for a representative boiling water reactor (BWR) spent nuclear fuel (SNF) assembly for the first one million years after the SNF is discharged from the reactors. This calculation includes an examination of several ways to represent BWR assemblies and operatingmore » conditions in SAS2H in order to quantify the effects these representations may have on source terms. These source terms provide information characterizing the neutron and gamma spectra in particles per second, the decay heat in watts, and radionuclide inventories in curies. Source terms are generated for a range of burnups and enrichments (see Table 2) that are representative of the waste stream and stainless steel (SS) clad assemblies. During this revision, it was determined that the burnups used for the computer runs of the previous revision were actually about 1.7% less than the stated, or nominal, burnups. See Section 6.6 for a discussion of how to account for this effect before using any source terms from this calculation. The source term due to the activation of corrosion products deposited on the surfaces of the assembly from the coolant is also calculated. The results of this calculation support many areas of the Monitored Geologic Repository (MGR), which include thermal evaluation, radiation dose determination, radiological safety analyses, surface and subsurface facility designs, and total system performance assessment. This includes MGR items classified as Quality Level 1, for example, the Uncanistered Spent Nuclear Fuel Disposal Container (Ref. 7.27, page 7). Therefore, this calculation is subject to the requirements of the Quality Assurance Requirements and Description (Ref. 7.28). The performance of the calculation and development of this document are carried out in accordance with AP-3.124, ''Design Calculation and Analyses'' (Ref. 7.29).« less

Analysis of the accidental explosion at Pepcon, Henderson, Nevada, May 4, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reed, J.W.

Several hours of fire and numerous explosions destroyed the Pacific Engineering Company plant in Henderson, Nevada, that manufactured ammonium perchlorate (AP) for rocket fuel. This incident began about 1130 PDT on May 4, 1988, with a fire in their Batch House that grew out of control and caused a first large explosion at about 1153 PDT. The final and largest explosion occurred about 1157 PDT. Damages to the surrounding community were surveyed and interpreted as airblast overpressures versus distances, which allowed an estimate of 1-kiloton nuclear free-air-burst for the equivalent explosion yield. This could be reproduced by 250-tons TNT burstmore » on the ground surface. Weather reports were obtained from the National Weather Services which indicated somewhat enhanced airblast propagation downwind toward northerly directions and attenuated airblast propagations upwind in southerly directions. It was impossible, for lack of winds aloft information below about 500 m above ground, to determine whether there was any atmospheric acoustic airblast focusing. Several seismic recordings in Las Vegas showed the greatest ground motion resulted from the airblast wave passage, traveling at near acoustic speed. Ground wave arrival times were not sufficiently precise to allow seismic speed interpretations. Of the 4000 tons of AP apparently stored in and around the plant, it appears that about 1500 tons detonated in the largest explosion. This leads to a conclusion that the TNT airblast equivalence factor for AP is near 1/6. An independent estimate, based on analysis of more ideal close-in structural deformations, suggested an equivalence factor of 1/3. 25 refs., 12 figs., 14 tabs.« less

75 FR 30405 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... Revocable Trust, James E. Ukrop, Trustee; Robert Stephen Ukrop; The Amended and Restated Robert Stephen Ukrop Revocable Trust, Robert Stephen Ukrop, Trustee; Robert Scott Ukrop; The Amendment and Restatement.... Ukrop; The Robert Stephen Ukrop, Revocable Trust, Joseph Ukrop, Jr., Trustee; Jacquelin Ukrop Aronson...

Robert S. Nelson | NREL

Science.gov Websites

S. Nelson Photo of Robert S. Nelson Robert Nelson Researcher II-Biological Science Robert.Nelson recombinant proteins. His current work is focused on the biological conversion of lignocellulose to advanced

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

34 CFR 654.1 - What is the Robert C. Byrd Honors Scholarship Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Robert C. Byrd Honors Scholarship Program...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ROBERT C. BYRD HONORS SCHOLARSHIP PROGRAM General § 654.1 What is the Robert C. Byrd Honors Scholarship Program? Under the Robert C. Byrd Honors...

Recombinant rabbit leukemia inhibitory factor and rabbit embryonic fibroblasts support the derivation and maintenance of rabbit embryonic stem cells.

PubMed

Xue, Fei; Ma, Yinghong; Chen, Y Eugene; Zhang, Jifeng; Lin, Tzu-An; Chen, Chien-Hong; Lin, Wei-Wen; Roach, Marsha; Ju, Jyh-Cherng; Yang, Lan; Du, Fuliang; Xu, Jie

2012-08-01

The rabbit is a classical experimental animal species. A major limitation in using rabbits for biomedical research is the lack of germ-line-competent rabbit embryonic stem cells (rbESCs). We hypothesized that the use of homologous feeder cells and recombinant rabbit leukemia inhibitory factor (rbLIF) might improve the chance in deriving germ-line-competent rbES cells. In the present study, we established rabbit embryonic fibroblast (REF) feeder layers and synthesized recombinant rbLIF. We derived a total of seven putative rbESC lines, of which two lines (M5 and M23) were from culture Condition I using mouse embryonic fibroblasts (MEFs) as feeders supplemented with human LIF (hLIF) (MEF+hLIF). Another five lines (R4, R9, R15, R21, and R31) were derived from Condition II using REFs as feeder cells supplemented with rbLIF (REF+rbLIF). Similar derivation efficiency was observed between these two conditions (8.7% vs. 10.2%). In a separate experiment with 2×3 factorial design, we examined the effects of feeder cells (MEF vs. REF) and LIFs (mLIF, hLIF vs. rbLIF) on rbESC culture. Both Conditions I and II supported satisfactory rbESC culture, with similar or better population doubling time and colony-forming efficiency than other combinations of feeder cells with LIFs. Rabbit ESCs derived and maintained on both conditions displayed typical ESC characteristics, including ESC pluripotency marker expression (AP, Oct4, Sox2, Nanog, and SSEA4) and gene expression (Oct4, Sox2, Nanog, c-Myc, Klf4, and Dppa5), and the capacity to differentiate into three primary germ layers in vitro. The present work is the first attempt to establish rbESC lines using homologous feeder cells and recombinant rbLIF, by which the rbESCs were derived and maintained normally. These cell lines are unique resources and may facilitate the derivation of germ-line-competent rbESCs.

An Architecture for the Electronic Church: Oral Roberts University in Tulsa, Oklahoma.

PubMed

Grubiak, Margaret M

2016-04-01

More than a university, Oral Roberts University in Tulsa, Oklahoma, was also the headquarters for evangelist Oral Roberts's electronic church. The electronic church in America, dominated by Christian evangelicals, used technology to spread the Gospel over radio airways and television signals to a dispersed audience. Yet evangelicals like Roberts also constructed ambitious campuses in real space and time. The architecture of Oral Roberts University visualized a modern and "populuxe" image for the electronic church in the 1960s and 1970s. The university's Prayer Tower purposely alluded to the Seattle Space Needle, aligning religion and the Space Age, and the campus's white, gold, and black color palette on late modern buildings created an image of aspirational luxury, conveying Roberts's health and wealth gospel. Oral Roberts University served as a sound stage for Roberts's radio and television shows, a pilgrimage point for his audience, and a university dedicated to training evangelicals in the electronic church.

The Future of Educational Research.

ERIC Educational Resources Information Center

Farley, Frank H., Ed.

1982-01-01

Seven past presidents of the American Educational Research Association discuss trends and the probable nature of educational research in the 1980s. Authors include N.L. Gage, Benjamin S. Bloom, David R. Krathwohl, Robert M. Gagne, Robert Glaser, Robert Ebel, and Robert L. Thorndike. (GC)

a Look at Nitrile Chemistry in SGR B2(N) Using the Combined Power of the GBT and the VLA

NASA Astrophysics Data System (ADS)

Steber, Amanda; Zaleski, Daniel P.; Seifert, Nathan A.; Neill, Justin; Muckle, Matt; Pate, Brooks; Corby, Joanna F.; Remijan, Anthony

2014-06-01

Nitriles form the most prolific family of molecules known in the ISM, and laboratory work shows that radical-driven chemistry can account for the formation of a diverse set of nitrile and imine molecules. Broadband reaction screening of nitrile chemistry in a pulsed discharge nozzle coupled to a chirped-pulse Fourier transform rotational spectrometer has enabled detections of several new interstellar species including E- and Z-ethanimine and E-cyanomethanimine. The detections were made by direct comparisons of laboratory broadband rotational spectra with the Robert C. Byrd Green Bank Telescope (GBT) PRebiotic Interstellar MOlecule Survery (PRIMOS) survey towards Sgr B2(N), the most chemically complex interstellar region known. In order to probe nitrile chemistry in Sgr B2, we targeted low energy rotational transitions in the 18-21 GHz range of several nitriles with the Karl G. Jansky Very Large Array (VLA) at ˜1 arcsecond resolution. The data indicate that most nitriles and nitrile derivatives are co-spatial with shell shaped continuum features thought to be expanding ionization fronts. The CH2CN radical and imine species in particular are NOT associated with the hot core known as the "Large Molecule Heimat", where most large organic molecules are thought to reside. This result suggests radical driven nitrile chemistry may be promoted by near-UV radiation in moderate density regions of molecular clouds, and the data will be useful for evaluating possible formation mechanisms. R.A. Loomis et al. Ap. J. L., 765, (L9), 2013. D.P. Zaleski et al. Ap. J. L., 765, (L10), 2013.

77 FR 40609 - Robert D. Willis Power Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

... DEPARTMENT OF ENERGY Southwestern Power Administration Robert D. Willis Power Rate AGENCY... proposed Robert D. Willis rate schedule, which is supported by a power repayment study, to recover the... existing Robert D. Willis rate for the period October 1, 2008 through September 30, 2012. See 127 FERC...

Far-Field Accumulation of Fissile Material From Waste Packages Containing Plutonium Disposition Waste Form

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.P. Nicot

The objective of this calculation is to estimate the quantity of fissile material that could accumulate in fractures in the rock beneath plutonium-ceramic (Pu-ceramic) and Mixed-Oxide (MOX) waste packages (WPs) as they degrade in the potential monitored geologic repository at Yucca Mountain. This calculation is to feed another calculation (Ref. 31) computing the probability of criticality in the systems described in Section 6 and then ultimately to a more general report on the impact of plutonium on the performance of the proposed repository (Ref. 32), both developed concurrently to this work. This calculation is done in accordance with the developmentmore » plan TDP-DDC-MD-000001 (Ref. 9), item 5. The original document described in item 5 has been split into two documents: this calculation and Ref. 4. The scope of the calculation is limited to only very low flow rates because they lead to the most conservative cases for Pu accumulation and more generally are consistent with the way the effluent from the WP (called source term in this calculation) was calculated (Ref. 4). Ref. 4 (''In-Drift Accumulation of Fissile Material from WPs Containing Plutonium Disposition Waste Forms'') details the evolution through time (breach time is initial time) of the chemical composition of the solution inside the WP as degradation of the fuel and other materials proceed. It is the chemical solution used as a source term in this calculation. Ref. 4 takes that same source term and reacts it with the invert; this calculation reacts it with the rock. In addition to reactions with the rock minerals (that release Si and Ca), the basic mechanisms for actinide precipitation are dilution and mixing with resident water as explained in Section 2.1.4. No other potential mechanism such as flow through a reducing zone is investigated in this calculation. No attempt was made to use the effluent water from the bottom of the invert instead of using directly the effluent water from the WP. This calculation supports disposal criticality analysis and has been prepared in accordance with AP-3.12Q, Calculations (Ref. 49). This calculation uses results from Ref. 4 on actinide accumulation in the invert and more generally does reference heavily the cited calculation. In addition to the information provided in this calculation, the reader is referred to the cited calculation for a more thorough treatment of items applying to both the invert and fracture system such as the choice of the thermodynamic database, the composition of J-13 well water, tuff composition, dissolution rate laws, Pu(OH){sub 4} solubility and also for details on the source term composition. The flow conditions (seepage rate, water velocity in fractures) in the drift and the fracture system beneath initially referred to the TSPA-VA because this work was prepared before the release of the work feeding the TSPA-SR. Some new information feeding the TSPA-SR has since been included. Similarly, the soon-to-be-qualified thermodynamic database data0.ymp has not been released yet.« less

Determination of piroxicam in pharmaceutical preparations by ultraviolet direct spectrophotometry, ultraviolet difference spectrophotometry and high performance liquid chromatography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hackmann, E.R.M.; Santos Gianotto, E.A. dos; Miritello Santoro, M.I.R.

1993-02-01

Piroxicam in pharmaceutical preparations (capsules (C), tablets (T), oral drops (OD), suppositories (S) and simulated sample (SS)) was determined by UV direct spectrophotometry (UVS) at 333 nm, by UV difference spectrophotometry (UVDS) at 327 nm, and in C and T, by high performance liquid chromatography (HPLC). For UVS, Beer's law was obeyed in the range 3.0-8.5 [mu]g/mL. The coefficient of correlation (CC), absolute precision (AP) and relative precision (RP) were 0.9999, 0.02 and 0.33%, respectively. The coefficient of variation (CV) for C, T, OD, S and SS were 0.48%, 0.35%, 0.48% and 0.19%, respectively. The recovery average (RA) was 100.22%.more » For UVDS, Beer's law was obeyed in the range 5.0-15.0 [mu]g/mL. The CC, AP and RP were respectively 0.9999, 0.05 and 0.47%. The CV for C, T, OD, S and SS were 0.64%, 0.84%, 0.62%, 0.54% and 0.15%, respectively. The RA was 99.02%. In HPLC determination, a LiChrospher[reg sign] 100 RP-18 (5 [mu]m) in LiChroCART[reg sign] 125-4 column at ambient temperature with a mobile phase consisting of methanol: (buffer solution citric acid-dibasic sodium phosphate pH 3.0) (55:45) and UV detection at 254 nm enabled the determination of piroxicam in C and T. The response peak area versus concentration presented linearity in the range 10.0-100.0 [mu]g/mL. The CC, AP and RP were 0.9997, 0.45 and 0.90%, respectively. The CV was 0.51%-0.82% and the RA, 97.13%. 14 refs., 1 fig., 5 tabs.« less

Getting to Negotiations in Syria: The Shadow of the Future and the Syrian Civil War

DTIC Science & Technology

2014-01-01

parties are that there will be a tomorrow, the more willing they will become to talk about it. As Robert Axelrod and Robert O. Keohane write, “The more...N.J.: Princeton University Press, 2002. 35 Walter, 1997, p. 335. 36 Walter, 1997, p. 336. 37 Robert Axelrod and Robert O. Keohane , “Achieving...sovereign states may choose to cooperate under conditions of anarchy. According to Robert Axel- The literature has focused on conditions prior to or

76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-09

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

Robert Preus | NREL

Science.gov Websites

| 303-384-7284 Robert's expertise is in design and manufacture of small and midsized wind generators certification support for small wind manufacturers. Robert has 28 years of experience in wind energy. He led the section for wind in the National Electrical Code. In 2010, Robert received the Small Wind Advocate award

Radiographic Assessment of the Robert and Lateral Views in Trapeziometacarpal Osteoarthrosis.

PubMed

Oheb, Jonathan; Lansinger, Yuri; Jansen, Joshua A; Nguyen, Jimmy Q; Porembski, Margaret A; Rayan, Ghazi M

2015-01-01

To evaluate the effectiveness of the Robert view in assessing trapeziometacarpal arthrosis and to compare the accuracy of the Robert and lateral views in staging trapeziometacarpal (TM) joint arthrosis. Patient demographics were obtained. Four participating raters reviewed 62 randomly selected thumb x-rays of patients presenting with thumb TM joint pain. Lateral and Robert-hyperpronation views were assessed using an analysis of 13 criteria. X-rays of 62 thumbs for 58 patients were evaluated. The average patients' age was 64 (47-87) and 51 (80%) were females. The majority of X-rays evaluated fell into stage 3. Stage 2 was the second most common level of arthritis encountered and the least was stage 1. More osteophytes were encountered in the trapezium than metacarpal on both the Robert and lateral views. The Robert view was superior in detecting osteophytes on the trapezium than the lateral view. Osteophyte size varied from 1.7 to 2 mm. The lateral view displayed 61 cases with dorsal metacarpal subluxation (98%). The Robert view displayed 48 cases (77%) with radial metacarpal subluxation and 9 cases (15%) with ulnar metacarpal subluxation. Thumb metacarpal adduction deformity was encountered on the lateral view in 20 cases (32%) whereas on the Robert view it was encountered in 14 cases (23%). Subchondral sclerosis was encountered on the Robert view in 56 thumbs (90%) while it was seen on the lateral view in 52 thumbs (84%). Pantrapezial arthritis involving the STT joint was encountered equally in 16 cases (26%) on the Robert view and the lateral views. The study found a moderate level of interrater reliability on both the lateral and Robert views. With the exception of osteophytes encountered on the trapezium versus the metacarpal, there were no other statistically significant findings. This study confirms that each of the Robert and lateral views offer unique information and combining both views enhances the ability to assess radiographic disease severity, and should be the recommended set of X-rays for assessing TM osteoarthrosis.

76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-17

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-60] Robert G. Crummie, M.D... Registration, BC2964965, issued to Robert G. Crummie, M.D., be, and it hereby is, revoked. I further order that any pending application of Robert G. Crummie, M.D., to renew or modify his registration, be, and it...

Editorial

NASA Astrophysics Data System (ADS)

Kennicutt, Robert C., Jr.

1999-07-01

This issue marks the end of an era for The Astrophysical Journal and for astronomical publishing. Helmut Abt is retiring as Editor-in-Chief after serving for 28 years, a period that saw enormous growth in the Journal and its transformation to the forefront of electronic scientific publishing. In February the ApJ office celebrated the receipt of manuscript number 40,000 under Helmut's tenure, a milestone that testifies to his impact on all of our careers. Although the names at the top of the masthead are changing, the rest of the ApJ team remains nearly unchanged, so the editorial transition should be barely noticeable. Much of the editorial work of the Journal will continue to be performed by our capable staff of Scientific Editors. I am also very fortunate to inherit Helmut's outstanding support staff in Tucson, ably headed by Janice Sexton. Our publications staff in Chicago, led by Julie Steffen, and our electronic publications staff, led by Evan Owens, are unmatched in their dedication and energy, and I have already begun working with them on further improvements to the Journal. And Helmut Abt will continue to serve the Journal over the coming months, overseeing the manuscripts that are still under review and editing the special centennial issue that will appear at the end of this year. In the coming months we will introduce several new features, most of them initiated under Helmut Abt's leadership. These will include an upgraded ApJ homepage, web tools for authors and referees, updated documentation and author instructions, and an attractive new version of the on-line journal itself. Over the longer term we are developing plans for streamlining the publication timescale and for expanding our capabilities for publishing and archiving electronic data. However my overriding priority, always, will be to uphold the Journal's reputation for scientific accuracy, impact, and integrity. I close with a personal note of thanks to Helmut Abt for his patient tutoring over the past six months and for serving as an admirable role model with his dedication, fairness, wisdom, and grace. Our profession owes him an enormous debt of gratitude. ROBERT C. KENNICUTT, JR. Editor-in-Chief

Linear regression analysis of emissions factors when firing fossil fuels and biofuels in a commercial water-tube boiler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharon Falcone Miller; Bruce G. Miller

2007-12-15

This paper compares the emissions factors for a suite of liquid biofuels (three animal fats, waste restaurant grease, pressed soybean oil, and a biodiesel produced from soybean oil) and four fossil fuels (i.e., natural gas, No. 2 fuel oil, No. 6 fuel oil, and pulverized coal) in Penn State's commercial water-tube boiler to assess their viability as fuels for green heat applications. The data were broken into two subsets, i.e., fossil fuels and biofuels. The regression model for the liquid biofuels (as a subset) did not perform well for all of the gases. In addition, the coefficient in the modelsmore » showed the EPA method underestimating CO and NOx emissions. No relation could be studied for SO{sub 2} for the liquid biofuels as they contain no sulfur; however, the model showed a good relationship between the two methods for SO{sub 2} in the fossil fuels. AP-42 emissions factors for the fossil fuels were also compared to the mass balance emissions factors and EPA CFR Title 40 emissions factors. Overall, the AP-42 emissions factors for the fossil fuels did not compare well with the mass balance emissions factors or the EPA CFR Title 40 emissions factors. Regression analysis of the AP-42, EPA, and mass balance emissions factors for the fossil fuels showed a significant relationship only for CO{sub 2} and SO{sub 2}. However, the regression models underestimate the SO{sub 2} emissions by 33%. These tests illustrate the importance in performing material balances around boilers to obtain the most accurate emissions levels, especially when dealing with biofuels. The EPA emissions factors were very good at predicting the mass balance emissions factors for the fossil fuels and to a lesser degree the biofuels. While the AP-42 emissions factors and EPA CFR Title 40 emissions factors are easier to perform, especially in large, full-scale systems, this study illustrated the shortcomings of estimation techniques. 23 refs., 3 figs., 8 tabs.« less

Introduction to special issue: Robert Jay Kastenbaum (1932-2013).

PubMed

Fulton, Robert; Klass, Dennis; Doka, Kenneth J; Kastenbaum, Beatrice

The three pieces in this section introduce the Festschrift celebrating the works and influence of Omega: Journal of Death and Dying's founding editor, Robert Kastenbaum. Robert Fulton, an early Associate Editor of the Journal begins with some personal reflections on Kastenbaum. Klass and Doka then describe the nature of the Festschrift. A closing coda by Robert Kastenbaum's wife, Beatrice Kastenbaum, reminds us of the person behind the work.

Recombinant Rabbit Leukemia Inhibitory Factor and Rabbit Embryonic Fibroblasts Support the Derivation and Maintenance of Rabbit Embryonic Stem Cells

PubMed Central

Xue, Fei; Ma, Yinghong; Chen, Y. Eugene; Zhang, Jifeng; Lin, Tzu-An; Chen, Chien-Hong; Lin, Wei-Wen; Roach, Marsha; Ju, Jyh-Cherng; Yang, Lan; Du, Fuliang

2012-01-01

Abstract The rabbit is a classical experimental animal species. A major limitation in using rabbits for biomedical research is the lack of germ-line-competent rabbit embryonic stem cells (rbESCs). We hypothesized that the use of homologous feeder cells and recombinant rabbit leukemia inhibitory factor (rbLIF) might improve the chance in deriving germ-line-competent rbES cells. In the present study, we established rabbit embryonic fibroblast (REF) feeder layers and synthesized recombinant rbLIF. We derived a total of seven putative rbESC lines, of which two lines (M5 and M23) were from culture Condition I using mouse embryonic fibroblasts (MEFs) as feeders supplemented with human LIF (hLIF) (MEF+hLIF). Another five lines (R4, R9, R15, R21, and R31) were derived from Condition II using REFs as feeder cells supplemented with rbLIF (REF+rbLIF). Similar derivation efficiency was observed between these two conditions (8.7% vs. 10.2%). In a separate experiment with 2×3 factorial design, we examined the effects of feeder cells (MEF vs. REF) and LIFs (mLIF, hLIF vs. rbLIF) on rbESC culture. Both Conditions I and II supported satisfactory rbESC culture, with similar or better population doubling time and colony-forming efficiency than other combinations of feeder cells with LIFs. Rabbit ESCs derived and maintained on both conditions displayed typical ESC characteristics, including ESC pluripotency marker expression (AP, Oct4, Sox2, Nanog, and SSEA4) and gene expression (Oct4, Sox2, Nanog, c-Myc, Klf4, and Dppa5), and the capacity to differentiate into three primary germ layers in vitro. The present work is the first attempt to establish rbESC lines using homologous feeder cells and recombinant rbLIF, by which the rbESCs were derived and maintained normally. These cell lines are unique resources and may facilitate the derivation of germ-line-competent rbESCs. PMID:22775411

Robert Wood Johnson Foundation

MedlinePlus

Robert Wood Johnson Foundation Search How We Work Our Focus Areas About RWJF Search Menu How We Work Grants and Grant ... more For Grantees and Grantseekers The Robert Wood Johnson Foundation funds a wide array of programs which ...

Advanced pumped storage hydroelectric power may reduce NO{sub x} and VOC emissions

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

As a severe ozone nonattainment area, the New York/New Jersey metropolitan area faces the difficult challange of reducing emissions of nitrogen oxides (NO{sub x}) and volatile organic compounds (VOCs), the primary precursors of ground-level ozone. An ambitious,more » $$2.4 billion undertaking, known as the Mt. Hope project, may help the metropolitan area - and the entire Mid-Atlantic Ozone Transport Region (OTR) - attain ozone compliance. The project includes a new 2,000-MW electricity storage facility, which would allow thermal power plants in the region to run more efficiently and reduce NO{sub x} and VOC emissions, especially at times of critical ozone levels. The Mt. Hope project is the subject of a recent study that analyzed, potential reductions in ozone precursors from project implementation. According to the study, NO{sub x} emissions could be reduced by up to 50 tons per day and $$91 million per year could potentially be saved if the project is implemented. Advanced pumped storage (APS) improves significantly on the conventional method. The Mt. Hope project, for example, is expected to consume only 22% more electricity than it generates. APS facilities are designed to switch from power-receiving to power-generating modes frequently in response to demand - up to 20 times a day in the Mt. Hope design. 1 ref., 1 fig.« less

Persistent induction of c-fos and c-jun expression by asbestos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heintz, N.H.; Mossman, B.T.; Janssen, Y.M.

To investigate the mechanisms of asbestos-induced carcinogenesis, expression of c-fos and c-jun protooncogenes was examined in rat pleural mesothelial cells and hamster tracheal epithelial cells after exposure to crocidolite or chrysotile asbestos. In contrast to phorbol 12-myristate 13-acetate, which induces rapid and transient increases in c-fos and c-jun mRNA, asbestos causes 2- to 5-fold increases in c-fos and c-jun mRNA that persist for at least 24 hr in mesothelial cells. The induction of c-fos and c-jun mRNA by asbestos in mesothelial cells is dose-dependent and is most pronounced with crocidolite, the type of asbestos most pathogenic in the causation ofmore » pleural mesothelioma. Induction of c-jun gene expression by asbestos occurs in tracheal epithelial cells but is not accompanied by a corresponding induction of c-fos gene expression. In both cell types, asbestos induces increases in protein factors that bind specifically to the DNA sites that mediate gene expression by the AP-1 family of transcription factors. The persistent induction of AP-1 transcription factors by asbestos suggests a model of asbestos-induced carcinogenesis involving chronic stimulation of cell proliferation through activation of the early response gene pathway that includes c-jun and/or c-fos. 30 refs., 5 figs.« less

Conferencias a la Memoria de la Dra. Lydia J. Roberts 1967, 1969-1973 (Conferences in Memory of Dr. Lydia J. Roberts 1967, 1969-1973).

ERIC Educational Resources Information Center

Puerto Rico Univ., Rio Piedras.

This publication includes eleven lectures presented as part of a conference given honoring Dr. Lydia J. Roberts. Seven of the papers are written in the English language and four in Spanish. Most of the papers relate to the topic of nutrition, but a few pay tribute to Dr. Roberts in recognition of her distinguished leadership and teacher of human…

77 FR 44679 - Suntron Corporation, Including On-Site Leased Workers From Manpower, Nesco, TPI and Robert Half...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... workers leased from NESCO, TPI, and Robert Half working on-site at the Sugarland, Texas location of the... Suntron Corporation, including on-site leased workers from Manpower, NESCO, TPI, and Robert Half, Sugar...

The Sojourn Time in a Three Node, Acyclic, Jackson Queueing Network.

DTIC Science & Technology

1982-01-27

Effect of Intermediate Storage on Production Lines with Dependent Machines, Robert D. Foley and Petcharat Chansaenwilai 8015 Some Conditions for the...Queues, Robert D. Foley 8105 Reversibility of Production Lines with Dependent Machines, Petcharat Chansaenwilai 1 8106 Queues with Delayed Feedback, Robert

Editorial: Plant organ abscission: from models to crops

USDA-ARS?s Scientific Manuscript database

The shedding of plant organs is a highly coordinated process essential for both vegetative and reproductive development (Addicott, 1982; Sexton and Roberts, 1982; Roberts et al., 2002; Leslie et al., 2007; Roberts and Gonzalez-Carranza, 2007; Estornell et al., 2013). Research with model plants, name...

A Failure in Strategy: America and the Vietnam War 1965-1968

DTIC Science & Technology

2001-04-01

5 Robert S. McNamara, Argument Without End : In Search of Answers to the Vietnam Tragedy (New...McNamara, Robert S. Argument Without End : In Search of Answers to the Vietnam Tragedy . New York: Public Affairs, 1999. McNamara, Robert S. In Retrospect

Cryogenic Orbital Testbed (CRYOTE) Ground Test Article, Final Report

NASA Technical Reports Server (NTRS)

Johnson, Wesley L.; Rhys, Noah O.; Bradley, David E.; Wollen, Mark; Kutter, Bernard; Gravlee, Mari; Walls, Laurie K.

2015-01-01

Liquid propulsion has been used since Robert Goddard started developing a liquid oxygen (LO2) and gasoline powered rocket and fired it in 1923 (Ref. 1). In the following decades engineers settled on the combination of liquid hydrogen (LH2) and LO2 as the most efficient propellant combination for in-space travel. Due to their low temperatures (LH2 at 20 K and LO2 at 90 K), they require special handling and procedures. General Dynamics began developing LO2 and LH2 upper stages in 1956 in the form of Centaur, these efforts were soon funded by the Department of Defense in conjunction with NASA (beginning in 1958) (Ref. 2). Meanwhile NASA also worked with McDonnell Douglas to develop the SIV-B stage for the Saturn V rocket. In the subsequent years, the engineers were able to push the Centaur to up to 9 hr of orbital lifetime and the SIV-B to up to 6 hr. Due to venting the resultant boil-off from the high heat loads through the foam insulation on the upper stages, both vehicles remained in a settled configuration throughout the flights, thus the two phases of propellant (liquid and vapor) were separated at a known location. The one exception to this were the Titan/Centaur missions, which thanks to the lower boil-off using three layers of multilayer insulation (MLI), were able to coast unsettled for up to 5.25 hr during direct geosynchronous orbit insertion missions. In the years since there has been a continuous effort to extend the life of these upper stages from hours to days or even months.

75 FR 49950 - Robert Wayne Mosier, D.O.; Denial of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Wayne Mosier, D.O.; Denial of... Enforcement Administration, issued an Order to Show Cause to Robert Wayne Mosier, D.O. (Respondent), of... Osteopathic Examiners v. R. Wayne Mosier, D.O., No. 0712-0001 (June 18, 2009). Respondent also held an...

78 FR 2391 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RP13-436-000] CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and Electric Company... Energy Regulatory Commission (FERC); CAlifornians for Renewable Energy, Inc., Michael E. Boyd, and Robert...

76 FR 7837 - Ryan, Robert M.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6466-000] Ryan, Robert M.; Notice of Filing Take notice that on December 31, 2010, Robert M. Ryan submitted for filing, [email protected] , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5 p.m...

1. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic Stone Architecture of Winterset, Iowa, Prior to and During the Civil War Period.' Ames, IA: Iowa State University, 1960) Robert R. Harvey, delineator 1960 FLOOR PLAN, ORIGINAL HOUSE ('FIGURE 3-A') - Caleb Clark House, 814 South Eighth Street, Winterset, Madison County, IA

Embracing the Humanistic Vision: Recurrent Themes in Peter Roberts' Recent Writings

ERIC Educational Resources Information Center

Reveley, James

2018-01-01

Running like a leitmotif through Peter Roberts' recently published philosophico-educational writings there is a humanistic thread, which this article picks out. In order to ascertain the quality of this humanism, Roberts is positioned in relation to a pair of extant humanisms: radical and integral. Points of comparability and contrast are…

76 FR 54240 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

...: Robert G. Keefe, PhD, Scientific Review Officer, Scientific Review Program, DEA/NIAID/NIH/DHHS, Room 3256... Conference Call). Contact Person: Robert G. Keefe, PhD, Scientific Review Officer, Scientific Review Program... Drive, Bethesda, MD 20817 (Telephone Conference Call). Contact Person: Robert G. Keefe, PhD, Scientific...

DefenseLink.mil - Special Report - Travels With Gates

Science.gov Websites

of Estonia Estonia Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates walks with the Prime Minister of Estonia Andrus

Delivering Higher Education to Adults: An Interview with Robert Mendenhall

ERIC Educational Resources Information Center

Finney, Joni E.

2012-01-01

This article presents an interview with Robert Mendenhall, president of Western Governors University, who is the 2012 recipient of the Virginia B. Smith (VBS) Innovative Leadership Award. The annual award recognizes his leadership in redesigning higher education delivery for adult students. In the interview, Robert Mendenhall talks about his work…

Skull Size and Intelligence, and King Robert Bruce's IQ

ERIC Educational Resources Information Center

Deary, Ian J.; Ferguson, Karen J.; Bastin, Mark E.; Barrow, Geoffrey W. S.; Reid, Louise M.; Seckl, Jonathan R.; Wardlaw, Joanna M.; MacLullich, Alasdair M. J.

2007-01-01

An estimate of someone's IQ is a potentially informative personal datum. This study examines the association between external skull measurements and IQ scores, and uses the resulting regression equation to provide an estimate of the IQ of King Robert I of Scotland (Robert Bruce, 1274-1329). Participants were 48 relatively healthy Caucasian men…

Robert Goddard Young, DC, ND: Searching for a better way

PubMed Central

Brown, Douglas M.

2009-01-01

This biographical study tracks the life of Robert Goddard Young; a member of the Canadian Memorial Chiropractic College’s (CMCC) Class of 1950. The paper begins with an overview of Robert Young’s origins, his childhood and early training, moves to his tour of duty in World War II, followed by his education at CMCC, before converging on the core of this matter; Robert Young’s professional career, which spanned over half a century. Now in his twilight years, the paper ends with a discussion on the substance of Dr. Young’s largely-forgotten contributions. PMID:19714235

75 FR 69444 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-12

... South LaSalle Street, Chicago, Illinois 60690-1414: 1. Robert John Dentel, Victor, Iowa, and Mary P. Howell, Ames, Iowa, individually; and the Robert John Dentel Family (Robert J. Dentel, Patricia A. Dentel... Bank, Corydon, Iowa; First State Bank of Colfax, Colfax, Iowa; Maxwell State Bank, Maxwell, Iowa...

Behavior States and a Half-Full Glass: A Response to Mudford, Hogg, and Roberts.

ERIC Educational Resources Information Center

Arthur, Michael

2000-01-01

In this response to critiques (Mudford, Hogg and Roberts 1997, 1999) of the use of behavior states in research involving individuals with mental retardation, it is argued that the work on behavioral state analysis by Robert D. Guess has contributed to the field at the practical, empirical, and theoretical levels. (Contains references.) (CR)

Robert Curl, Jr. and the Discovery of Fullerenes

Science.gov Websites

produced thousands of variations of the buckyball, including carbon sheets one atom thick and microscopic equilibrium in the carbon vapor that allowed the group to identify a unique, 60-atom configuration of carbon Interview with Robert F. Curl, Jr., nobelprize.org (video) Interview with Robert Curl (video) Buckyballs

Tracing the Building of Robert's Connections in Mathematical Problem Solving: A Sixteen-Year Study

ERIC Educational Resources Information Center

Ahluwalia, Anoop

2011-01-01

This research analyzes how external representations created by a student, Robert, helped him in building mathematical understanding over a sixteen-year period. Robert (also known as Bobby), was an original participant of the Rutgers longitudinal study where students were encouraged to work on problem-solving tasks with minimum intervention (Maher,…

A Model for Modern Nonlinear Noncontiguous Operations: The War in Burma, 1943 to 1945

DTIC Science & Technology

2003-05-01

Approved by: _________________________________________ Monograph Director Robert M. Epstein, Ph.D...Professor and Director Robert H. Berlin, Ph.D. Academic Affairs, School of Advanced Military Studies _________________________________________ Director...I would like to thank Dr Robert Epstein for his guidance during the production of this monograph. My thanks also go to my Wife, Aly, for her patience

3. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic Stone Architecture of Winterset, Iowa, Prior to and During the Civil War Period.' Ames, IA: Iowa State University, 1960.) Robert R. Harvey, delineator 1960 FLOOR PLAN, ORIGINAL HOUSE PLUS SMOKEHOUSE ADDITION ('FIGURE 3-C') - Caleb Clark House, 814 South Eighth Street, Winterset, Madison County, IA

2. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of measured drawing (from: Harvey, Robert R. 'Historic Stone Architecture of Winterset, Iowa, Prior to and During the Civil War Period.' Ames, IA: Iowa State University, 1960.) Robert R. Harvey, delineator 1960 FLOOR PLAN, ORIGINAL HOUSE PLUS WELLHOUSE ADDITION ('FIGURE 3-B') - Caleb Clark House, 814 South Eighth Street, Winterset, Madison County, IA

76 FR 20033 - Robert Charles Ley, D.O. ; Dismissal of Proceeding

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-8] Robert Charles Ley, D.O... Charles Ley, D.O. (Respondent), of Kihei, Hawaii. Order to Show Cause at 1. The Order, which also sought... Suspension of Registration issued to Robert Charles Ley, D.O, be, and it hereby is, dismissed. Dated: April 1...

75 FR 57846 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1... installation, with replacement as necessary for Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1...

Structural Stability of a Joined-Wing Sensorcraft

DTIC Science & Technology

2007-06-01

Robert A. Canfield (Chairman) Date //SIGNED// Dr. Donald Kunz (Member) Date //SIGNED// Maj. Eric...to my thesis advisor, Dr. Robert Canfield, for his guidance and instruction throughout this thesis. His patience and availability were immensely...concept and provide detailed information with regards to the divergence of the linear and nonlinear analysis results of the SensorCraft. Roberts

Engineer Support to the Brigade Combat Team

DTIC Science & Technology

2010-05-20

Director, Robert F. Baumann, Ph.D. Graduate Degree Programs Disclaimer: Opinions, conclusions, and recommendations expressed or implied...companies, now totaling over seven thousand 12 Robert R. Ploger, MG, USA, Vietnam Studies: U.S...mission was complete they would be reallocated to other assets who needed them. The commander of the 18th Engineer Brigade, Major General Robert P

76 FR 51047 - North Dakota; Amendment No. 10 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... authority of the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... arrangements are warranted regarding Federal funds provided under the Robert T. Stafford Disaster Relief and... Assistance costs eligible for such adjustments under the law. The Robert T. Stafford Disaster Relief and...

76 FR 77728 - Process for a Designated Contract Market or Swap Execution Facility To Make a Swap Available To...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

..., 2011 at 9; Letter from Robert Pickel and Kenneth Bentsen, International Swaps and Derivatives..., dated Apr. 5, 2011 at 19; Letter from Robert Pickel and Kenneth Bentsen, International Swaps and... LLP, on behalf of certain dealers, dated Apr. 5, 2011 at 19; Letter from Robert Pickel and Kenneth...

Big Bang Cosmic Titanic: Cause for Concern?

NASA Astrophysics Data System (ADS)

Gentry, Robert

2013-04-01

This abstract alerts physicists to a situation that, unless soon addressed, may yet affect PRL integrity. I refer to Stanley Brown's and DAE Robert Caldwell's rejection of PRL submission LJ12135, A Cosmic Titanic: Big Bang Cosmology Unravels Upon Discovery of Serious Flaws in Its Foundational Expansion Redshift Assumption, by their claim that BB is an established theory while ignoring our paper's Titanic, namely, that BB's foundational spacetime expansion redshifts assumption has now been proven to be irrefutably false because it is contradicted by our seminal discovery that GPS operation unequivocally proves that GR effects do not produce in-flight photon wavelength changes demanded by this central assumption. This discovery causes the big bang to collapse as quickly as did Ptolemaic cosmology when Copernicus discovered its foundational assumption was heliocentric, not geocentric. Additional evidence that something is amiss in PRL's treatment of LJ12135 comes from both Brown and EiC Gene Spouse agreeing to meet at my exhibit during last year's Atlanta APS to discuss this cover-up issue. Sprouse kept his commitment; Brown didn't. Question: If Brown could have refuted my claim of a cover-up, why didn't he come to present it before Gene Sprouse? I am appealing LJ12135's rejection.

Serving the Needs of Gifted Learners around the Globe: An Interview with Julia Link Roberts

ERIC Educational Resources Information Center

Henshon, Suzanna E.

2018-01-01

Julia Link Roberts is the Mahurin Professor of Gifted Studies at Western Kentucky University (WKU) and the executive director of The Center for Gifted Studies and The Gatton Academy of Mathematics and Science in Kentucky. Dr. Roberts is the president of the World Council for Gifted and Talented Children; current past-president of The Association…

78 FR 22284 - Notice of Intent To Repatriate a Cultural Item: U.S. Department of the Interior, Bureau of Indian...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... Affairs, Washington, DC, and the Robert S. Peabody Museum of Archaeology, Phillips Academy, Andover, MA..., Washington, DC, and in the physical custody of the Robert S. Peabody Museum of Archaeology, Phillips Academy... Archaeology, Phillips Academy, Andover, MA Officials of the Bureau of Indian Affairs and the Robert S. Peabody...

The Marine Corps Martial Arts Program: Sustaining the Transformation

DTIC Science & Technology

2002-04-01

Approved: _______________ Date: _______________ Mentor: Colonel Robert P. Wagner, USMC Approved: _______________ Date: _______________ REPORT... Robert Debs Heinl Jr., USMC (Ret.), Soldiers of the Sea (Annapolis, MD: United States Naval Institute, 1962), 603. 7 constituency of the force, as well...changes over decades, the Marine Corps has shown the ability to adapt its training to meet those conditions. As Colonel Robert Wagner noted, over time

Development of Amphibious Doctrine

DTIC Science & Technology

2010-06-11

Graduate Degree Programs Robert F. Baumann, Ph.D. The opinions and conclusions expressed herein are those of the student author and do not...battalion composed of six companies of Marines, its commander, Lieutenant Colonel Robert W. Huntington, finally received the mission of securing an...42,000 men. The participants included the Commanding Officer, Marine Corps Schools, Colonel Robert Dunlap, as well as the students and instructors

Military Governance and War Termination

DTIC Science & Technology

2011-05-19

Military Studies ___________________________________ Director, Robert F. Baumann, Ph.D. Graduate Degree Programs Disclaimer: Opinions...77 J. Boone Barthlomees, “Theory of Victory,” Parameters XXVII, no. 2 (Summer 2008), 27. 78 Robert Mandel, “Reassessing Victory in Warfare." Armed...political goals, but not, for whatever reasons, reaching total political success.”80 A critical point presented by Dr. Robert Mandel is that victory is

Robert Klopstock and Franz Kafka--the friends from Tatranské Matliare (the High Tatras).

PubMed

Mydlík, M; Derzsiová, K

2007-01-01

The paper summarises the accessible literature on the life and work of well-known American lung surgeon, Professor Dr. Med. Robert Klopstock, who was in the years 1920-1924 a friend Franz Kafka. Professor Klopstock was of Hungarian origin and he got acquainted with Franz Kafka at the end of the year 1920 in Tatranské Matliare (The High Tatras). They were both patients treated for lung tuberculosis. They became close friends and their mutual correspondence shows their real friendship. Robert Klopstock was present at Franz Kafka's death-bed on June 3, 1924 in Kierling, near Klosterneuburg, not far from Vienna. Robert Klopstock studied at Medical Faculties of the Universities in Budapest, Prague, Kiel and Berlin. After his graduation in 1933 in Berlin, he worked as a lung surgeon at various surgical clinics and departments in Budapest and Berlin. In 1936 Robert Klopstock together with his wife visited the High Tatras and Tatranské Matliare. In 1937 Robert Klopstock with his wife Gizela, a writer and a translator, who translated the first chapters of Franz Kafka's novel "Trial" into Hungarian language, went to United States of America. During his stay in U.S.A. Dr. Med. Robert Klopstock was very active as a lung surgeon and a scientist. He published 64 specialized scientific papers, mostly in American medical journals. He became Professor of Lung Surgery at Downstate Medical Centre in New York-Brooklyn. He died on June 15, 1972 in New York.

A Conversation with Robert F. Christy Part I

NASA Astrophysics Data System (ADS)

Lippincott, Sara

2006-09-01

Robert F. Christy, Institute Professor of Theoretical Physics Emeritus at Caltech, recalls his childhood in British Columbia; his undergraduate years at the University of British Columbia; his graduate work with J. Robert Oppenheimer at Berkeley; and his work on the Manhattan Project, first with Enrico Fermi at the Metallurgical Laboratory of the University of Chicago and then as a member of the Theoretical Division at Los Alamos.

Studying Materials Using Acoustic Waves

DTIC Science & Technology

1988-03-01

Biological Materials." J. Acoust. Soc. Am. 7£, 636 (1981). Robert E. Apfel "Acoustic Cavitation : A Possible Consequence of Biomedical Uses of Ultrasound ...Soc. Am. 19_, 148 (1986). Robert E. Apfel "Possibility of Micro- Cavitation from Diagnostic Ultrasound ." IEEE Trans. on Ultrasonics...Madanshetty and R.A. Roy "Thresholds for Acoustic Cavitation Produced in Water by Pulsed Ultrasound ." Ultrasonics (UK) - in Press. Robert E. Apfel

Army Amateur Radio System: 1925-1941

DTIC Science & Technology

2010-05-21

1948 Captain Robert L. Gabardy selected the use of the acronym MARS, the Roman god of war, as a fitting name for the post-World War II rebirth of the...3 Robert L. Gabardy , telephonic interview by author, January 26, 2010. In approaching its mission as an auxiliary, MARS can examine...accessed January 25, 2010). Interviews Gabardy , Robert L., interview by author, January 26, 2010. Hart, George, interview by author, January 27

Games for Health, 2011

DTIC Science & Technology

2011-06-01

The Games for Health Project, an effort organized by Digitalmill, Inc. with funding from the Robert Wood Johnson Foundation held its 7th Annual Games...features, media and design patterns associated with videogames. Some of this work is already being done by academia and grantees of Robert Wood ...for game-based interventions really exists (or doesn’t) that can be beneficial to future funding efforts by organizations such as Robert Wood Johnson

Looking Forward: Texas and Its Elderly. Highlights of the Robert Lee Sutherland Seminar (4th, Austin, Texas, May 12, 1984).

ERIC Educational Resources Information Center

Coleman, Marion Tolbert, Ed.; And Others

This document presents the program agenda and highlights from the one-day Robert Lee Sutherland Seminar held to examine the current status and the future of the elderly population of Texas. Included is the speech, "The Longevity Revolution" by Robert N. Butler, in which is discussed the gain in life expectancy, the feminization of aging,…

High Frontier, The Journal for Space & Missile Professionals. Volume 4, Number 4

DTIC Science & Technology

2008-08-01

46 Next Issue: Space Protection High Frontier Introduction General C . Robert Kehler Commander, Air Force Space Command “ The ... the Air Force and General C . Robert “Bob” Kehler (BS, Education, Pennsylvania State University; MS, Public Administra- tion, University of Oklahoma...depth interview with Dr. F. Robert Naka, former deputy director of the NRO (1969- 1972 ) and former chief scientist of the Air Force (1975-1978

The Effect of Advanced Education on the Retention and Promotion of Army Officers

DTIC Science & Technology

2007-03-01

2 Ronal G.Ehrenberg, Robert S.Smith, Modern Labor Economics , Theory and Public Policy, (New York: Pearson Education, Inc, 2006...Ehrenberg and Robert S. Smith, Modern Labor Economics , 9th ed. (New York: Pearson Education, Inc, 2006). 30 G S Becker, Human Capital: A Theoretical...their jobs. As a 32 Ronald G. Ehrenberg and Robert S. Smith, Modern Labor Economics , 9th ed. (New

75 FR 32093 - Revision of Restricted Area R-2504; Camp Roberts, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

...-0557; Airspace Docket No. 10-AWP-6] RIN 2120-AA66 Revision of Restricted Area R-2504; Camp Roberts, CA... Restricted Area R-2504, Camp Roberts, CA, by subdividing the area of R-2504 to create R-2504A and R-2504B. Together, R-2504A and R-2504B will occupy the same lateral and vertical dimensions of the existing R-2504...

Tales from the hundred year history of the American Physical Society

NASA Astrophysics Data System (ADS)

Lustig, H.

1999-05-01

The tale to be told on this occasion - a tale only slightly out of school - is that of the punctuated evolution of the APS in pursuing its hundred years old mission, "the advancement and diffusion of the knowledge of physics". For long periods this goal was pursued, singlemindedly and impressively, through scientfic meetings and the Society's journals. However, within a year of its founding, the APS,in concert with other scientific societies, had already "lobbied" successfully for the establishment of the Bureau of Standards. But then all was quiet on the public front until after World War II. Since that time there have been three waves of forays into the public arena. The first, which spanned the "McCarthy period", was in defense of the freedom of scientists to practice their profession across national boundaries; of the right to announce the results of their research even if they trod on powerful toes (the Astin case); and of individual physicists, such as E.U. Condon and J.Robert Oppenheimer,who had been unfairly accused and badly treated. The second wave occurred in the late sixties and early seventies when, initially much pushed by activist members, the Society's leadership came to grips with broad social issues, such as segregation in the South, the Equal Rights Amendment, and, eventually, arms control and nuclear weapons. The third immersion in public affairs, which is still very much in progress, can be characterized as worrying and speaking out on what physics can do for the country (provide authoritative studies on nuclear energy, renewables, directed energy weapons, etc.) and what the country can do for physics (provide more money). Although lobbying for better funding is still a relatively minor occupation of the Society, it raises the question how physics -an elitist pursuit -can be truthfully and effectively "sold" in a democratic and egalitarian society.

Dr. Robert Goddard

NASA Image and Video Library

2010-01-04

Dr. Robert Goddard and colleagues at Roswell, New Mexico. Successful test of May 19, 1937. Dr. Robert Goddard is holding the cap and pilot parachute, parts of the successful operation. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

The Evolution of Marine Artillery: A History of Versatility and Relevance

DTIC Science & Technology

2012-03-28

Colonel Robert W. Huntington who commanded it, was formed. This included one artillery company manning four 3-inch rapid fire guns.7 The Marine...Major Robert H. Dunlap. That same battalion, which would soon be the foundation for the 10th Marine Regiment, distinguished itself in combat at La...force capable of counter-guerilla operations. Of note, Colonel Robert H. Dunlap commanded the regiment. 19 Officers during this period were versatile

Sustaining Equipment and the Rapid Acquisition Process: The Forgotten Phase

DTIC Science & Technology

2012-02-24

Operation of the Defense Acquisition System,” December 8, 2008. 7 Rasch , Robert. A, Jr. Lessons Learned from Rapid Acquisition: Better, Faster, Cheaper...Life Cycle Management Responsibilities,” Defense AR Journal, 17.2 (April 2010): 183. 37 Robert A. Rasch , Lessons Learned from Rapid Acquisition: Better...Accountability Office (GAO) Report, Subject: Rapid Acquisition of Mine Resistant Protected Vehicles, July 15, 2008, 4. 39 Ibid. 40 Ibid. 41 Robert A. Rasch

The Operational Air National Guard: Relationship Changes and Policy Implications

DTIC Science & Technology

2015-02-13

Operational ANG” after U.S. withdrawal from Iraq and Afghanistan. Secretary of Defense Robert Gates’ 19 January 2007 memo, “Utilization of the Total...the RCs provide strategic depth and are available to transition to operational roles as needed. 25 Secretary of Defense, Robert M. Gates, 19...An Illustrated History of America’s Citizen-Soldiers. Dulles, VA: Potomac Books Inc., 2007. Gates, Robert M., U.S. Secretary of Defense. To

An Extensive X-ray Computed Tomography Evaluation of a Fully Penetrated Encapsulated SiC MMC Ballistic Panel

DTIC Science & Technology

2009-04-01

An Extensive X-ray Computed Tomography Evaluation of a Fully Penetrated Encapsulated SiC MMC Ballistic Panel by William H. Green and Robert H...Panel William H. Green and Robert H. Carter Weapons and Materials Research Directorate, ARL...PROGRAM ELEMENT NUMBER 2182040 6. AUTHOR(S) William H. Green and Robert H. Carter 5d. PROJECT NUMBER AH80 5e. TASK NUMBER 5f. WORK UNIT

Building Component Maintenance and Repair Data Base: Heating, Ventilating, and Air Conditioning (HVAC) Systems

DTIC Science & Technology

1991-05-01

Building Component Maintenance and Repair Data Base: Heating, Ventilating, and Air Conditioning (HVAC) Systems by Edgar S. Neely Robert D. Neathammer...Repair Data Base: Heating, Ventilating, and Air Conditioning (HVAC) Systems RDTE dated 1980EIMB 1984 - 1989 6. AUTHOR(S) Edgar S. Neely, Robert D...Laboratory (USACERL). The Principal Investigators were Dr. Edgar Neely and Mr. Robert Neathammer (USACERL-FS). The primary contractor for much of the

Defense Planning for the 1990s and the Changing International Environment

DTIC Science & Technology

1984-01-01

Atlantic Alliance: Looking Ahead ................. 87 Dr. Robert L. Pfaltzgraff, Jr. The Future of the American NATO Commitment ......... 109 Dr...avenues of approach to the ques- tion. Dr. George H. Quester approached NATO’s future from the peespective of American political philosophy. Dr. Robert L...offices whose assign- ment would be to conduct long-range planning on a continuing basis. 85 The Atlantic Alliance: Looking Ahead Dr. Robert L. Pfaltzgraff

Development of a Robust Static Punch Experiment for Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material

DTIC Science & Technology

2014-09-01

Cross-Ply Material by David Gray, Robert Kaste , and Paul Moy ARL-TR-7090 September 2014...Screening Unprocessed Ultra-High Molecular Weight Polyethylene (UHMWPE) Unidirectional Cross-Ply Material David Gray, Robert Kaste , and Paul...ELEMENT NUMBER 6. AUTHOR(S) David Gray, Robert Kaste , and Paul Moy 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7

Civil-Military Relations: From Vietnam to Operation Iraqi Freedom

DTIC Science & Technology

2009-05-01

Robert F. Baumann, Ph.D. Graduate Degree Programs ii Abstract CIVIL-MILITARY RELATIONS: FROM VIETNAM TO OPERATION IRAQI FREEDOM by MAJOR Brandon...Oxford: Oxford University Press, 2007), 285-324. 43 Ibid. 44 Robert M. Gates, 2008 National Defense Strategy (Washington D.C.: Department Of Defense...Dereliction of Duty: Lyndon Johnson, Robert McNamara, the Joint Chiefs of Staff, and the Lies That Led to Vietnam (New York: HarperCollins, 1997), 13. 60

Organizational Culture Challenges to Interagency and Intelligence Community Communication and Interaction

DTIC Science & Technology

2006-05-31

York: McGraw-Hill, 2003), p 121. 103 Gortner, Mahler, and Nicholson, p 74. 104 Robert B. Denhardt, Theories of Public Organization. (Belmont, CA...Uninformed: Government Secrecy in the 1980’s. New York: Pilgrim Press, 1984. Denhardt, Robert B. Theories of Public Organization. Belmont, CA: Brooks/Cole...Fixing Intelligence: For a More Secure America. New Haven, CT: Yale University Press, 2003. Odom, William E. and Robert Dujarric. America’s Inadvertent

Improvements to the Understanding of the Fire Performance of Wood over the Past 30 Years-A Tribute to Robert Hawthorne White

Treesearch

Samuel L. Zelinka; Mark A. Dietenberger; Laura E. Hasburgh; Keith J. Bourne; Charles Boardman

2015-01-01

Dr. Robert Hawthorne White had a 31 year career researching the fire performance of wood and wood composites at the USDA Forest Products Laboratory. Over his career, Dr. White made substantial contributions to codes, standards, and regulations pertaining to the design of wood structures. This review article summarizes Robert’s major accomplishments as a tribute to his...

In re Marriage of Moschetta.

PubMed

1994-06-10

Cynthia Moschetta petitioned to obtain separation from her husband, Robert Moschetta, and to establish her maternity as to Marissa Moschetta, who was conceived pursuant to a traditional surrogacy contract. Elvira Jordan, the surrogate mother, sought to join the dissolution action, and Robert Moschetta requested judgment of dissolution. The Orange County Superior Court awarded joint legal and physical custody to Elvira Jordan and Robert Moschetta. Robert Moschetta appealed, challenging the determination that Jordan is the legal mother of Marissa and contending that Cynthia Moschetta is the legal mother of the child by virtue of the Uniform Parentage Act. The appellate court affirmed Jordan's parental rights, reversed the awarding of joint physical custody, remanded the latter question for reevaluation, and called for legislative guidance on the problems arising from surrogacy arrangements.

John Bowlby and ethology: an annotated interview with Robert Hinde.

PubMed

Bowlby, John

2007-12-01

From the 1950s, John Bowlby, one of the founders of attachment theory, was in personal and scientific contact with leading European scientists in the field of ethology (e.g., Niko Tinbergen, Konrad Lorenz, and especially Robert Hinde). In constructing his new theory on the nature of the bond between children and their caregivers, Bowlby profited highly from their new approach to (animal) behavior. Hinde and Tinbergen in their turn were influenced and inspired by Bowlby's new thinking. On the basis of extensive interviews with bowlby's colleague and lifelong friend Robert Hinde and on the basis of archival materials, both the relationship between John Bowlby and Robert Hinde and the cross-fertilization of ethology and attachment theory are described.

A Legion Apart

DTIC Science & Technology

2012-03-16

NUMBER Colonel Robert Mundell Department of Command, Leadership, & Management 9. SPONSORING...Colonel Robert Mundell Project Adviser This SRP is submitted in partial fulfillment of the requirements of the Master of

Robot navigation research at CESAR (Center for Engineering Systems Advanced Research)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnett, D.L.; de Saussure, G.; Pin, F.G.

1989-01-01

A considerable amount of work has been reported on the problem of robot navigation in known static terrains. Algorithms have been proposed and implemented to search for an optimum path to the goal, taking into account the finite size and shape of the robot. Not as much work has been reported on robot navigation in unknown, unstructured, or dynamic environments. A robot navigating in an unknown environment must explore with its sensors, construct an abstract representation of its global environment to plan a path to the goal, and update or revise its plan based on accumulated data obtained and processedmore » in real-time. The core of the navigation program for the CESAR robots is a production system developed on the expert-system-shell CLIPS which runs on an NCUBE hypercube on board the robot. The production system can call on C-compiled navigation procedures. The production rules can read the sensor data and address the robot's effectors. This architecture was found efficient and flexible for the development and testing of the navigation algorithms; however, in order to process intelligently unexpected emergencies, it was found necessary to be able to control the production system through externally generated asynchronous data. This led to the design of a new asynchronous production system, APS, which is now being developed on the robot. This paper will review some of the navigation algorithms developed and tested at CESAR and will discuss the need for the new APS and how it is being integrated into the robot architecture. 18 refs., 3 figs., 1 tab.« less

Robert Tirawat | NREL

Science.gov Websites

-performance, high-reliability systems that use concentrated sunlight to generate power. Recently, Robert has been involved developing a high-efficiency solar selective absorber and anti-corrosion coatings

Numerical Methods in Atmospheric and Oceanic Modelling: The Andre J. Robert Memorial Volume

NASA Astrophysics Data System (ADS)

Rosmond, Tom

Most people, even including some in the scientific community, do not realize how much the weather forecasts they use to guide the activities of their daily lives depend on very complex mathematics and numerical methods that are the basis of modern numerical weather prediction (NWP). André Robert (1929-1993), to whom Numerical Methods in Atmospheric and Oceanic Modelling is dedicated, had a career that contributed greatly to the growth of NWP and the role that the atmospheric computer models of NWP play in our society. There are probably no NWP models running anywhere in the world today that do not use numerical methods introduced by Robert, and those of us who work with and use these models everyday are indebted to him.The first two chapters of the volume are chronicles of Robert's life and career. The first is a 1987 interview by Harold Ritchie, one of Robert's many proteges and colleagues at the Canadian Atmospheric Environment Service. The interview traces Robert's life from his birth in New York to French Canadian parents, to his emigration to Quebec at an early age, his education and early employment, and his rise in stature as one of the preeminent research meteorologists of our time. An amusing anecdote he relates is his impression of weather forecasts while he was considering his first job as a meteorologist in the early 1950s. A newspaper of the time placed the weather forecast and daily horoscope side by side, and Robert regarded each to have a similar scientific basis. Thankfully he soon realized there was a difference between the two, and his subsequent career certainly confirmed the distinction.

The Vietnam Cauldron: Defense Intelligence in the War for Southeast Asia

DTIC Science & Technology

2012-01-01

For the Patriots. Major Robert P. Perry, USA Celeste M. Brown Vivienne A. Clark Dorothy M. Curtiss Joan K. Pray Doris J. Watkins Colonel Charles R. Ray...USA Chief Warrant Officer Robert W. Prescott, USA Chief Warrant Officer Kenneth D. Welch, USA Petty Officer First Class Michael R. Wagner, USN...Marshall Karl W. Teepe Patricia E. Mickley Robert J. Hymel Rosa M. Chapa Sandra N. Foster Charles E. Sabin i Defense Intelligence Historical Perspectives

China: Suspected Acquisition of U.S. Nuclear Weapon Secrets

DTIC Science & Technology

2006-02-01

Benjamin Kang, “China Nuclear Halt May Stem From Deal,” Reuters, July 30, 1996; Robert Karniol, “Nuclear Blast Heralds A Chinese Moratorium,” Jane’s Defense...Leak,” New York Times, April 8, 1999. 12 FBI, “Statement by FBI Director Robert S. Mueller,” April 9, 2003; Katrina Leung Affidavit; James J. Smith...the appropriate congressional committees and the White House on April 21, 1999. Robert Walpole, the National Intelligence Officer for Strategic and

Reducing Long-Term Costs While Preserving a Robust Strategic Airlift Fleet: Options for the Current Fleet and Next-Generation Aircraft

DTIC Science & Technology

2013-01-01

Ghashghai, Jeff Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert S. Leonard, Rosalind Lewis, Elvira N. Loredo, Daniel M. Norton, David T...Joan Cornuet, Mel Eisman, Chris Fitzmartin, Jean R. Gebman, Elham Ghashghai, Jeff Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert...Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert S. Leonard, Rosa- lind Lewis, Elvira N. Loredo, Daniel M. Norton, David T. Orletsky

Building Maintenance and Repair Data for Life-Cycle Cost Analyses: Electrical Systems.

DTIC Science & Technology

1991-05-01

Repair Data for Life-Cycle Cost Analyses: Electrical Systems by Edgar S. Neely Robert D. Neathammer James R. Stirn Robert P. Winkler This research...systems have been developed to assist planners in preparing DD Form 1391 documentation, designers in life-cycle cost component selection, and maintainers...Maintenance and Repair Data for Life-Cycle Cost Analyses: RDTE dated 1980 Electrical Systems REIMB 1984 - 1989 6. AUTH4OR(S) Edgar S. Neely, Robert D

Getting America Ready for Japanese Science and Technology Held at Washington, DC on 7-8 February 1985.

DTIC Science & Technology

1985-05-15

TRANSLATION: A LONG-TERM SOLUTION MACHINE TRANSLATIONS: DEVELOPMENTS AND PROSPECTS 96 Robert A. Russell, Assistant Professor, Department of Asian and...chairman of the board of WCC, Chicago. He is a member of the Japanese National Automatic Translation Telephone Development Committee. 1 ROBERT A. RUSSELL...redussol- Westerism through indexing enineiring student to trai- speaking M Ono"e langisage. 067 pubfiahang-some in services. said Robert W. Gib- law

Structural Optimization of a Distributed Actuation System in a Flexible In-Plane Morphing Wing

DTIC Science & Technology

2007-06-01

Captain, USAF Approved: /signed/ 11 Jun 2007 Dr. Robert Canfield (Chairman) date /signed/ 11 Jun 2007 Dr. Brian Sanders (Member) date /signed/ 11 Jun...can be seen here at the Camp Roberts Flight Test Range [11]. separation, which ultimately increased the overall lift. During wind tunnel tests, the...Matlabr . The outermost loop was written by Mark Spillman and Dr. Robert Canfield and was based on Schittkowski’s Sequential Quadratic Programming (SQP

The Federal Role in Funding State and Local Infrastructure: Two Reports on Public Works Financing

DTIC Science & Technology

1993-08-01

comments are welcome on any of these reports. For further information on the Federal Infrastructure Strategy Program, please contact Robert A. Pietrowsky ...Eugene Z. Stakhiv, Chief, Policy and Special Studies Division; and the FIS Study Team which includes Mr. Robert A. Pietrowsky , Program Manager, Mr...and visiting fellow of the Navigation Division of IWR, and Mr. Robert Pietrowsky for their helpful comments on the introduction. Mention must also be

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, J.; Liu, C.; Koopman, W.J.

Ligation of the Fas cell-surface molecule induces apoptosis. Defective Fas-mediated apoptosis has been associated with spontaneous autoimmunity in mice. Using human Fas/Apo-1 cDNA as a probe, the authors have molecularly cloned and characterized the human Fas chromosomal gene. The gene consists of nine exons and spans more than 26 kilobases of DNA. The lengths of introns vary from > 14 kilobases at the 5` end of the gene to 152 base pairs upstream of the exon encoding the transmembrane domain. The domain structure of the human Fas is encoded by an exon or a set of exons. Primer extension analysismore » revealed three major transcription initiation sites. The promoter region lacked canonical {open_quotes}TATA{close_quotes} and {open_quotes}CAAT{close_quotes} boxes but was a {open_quotes}GC-rich{close_quotes} sequence, and contained consensus sequences for AP-1, GF-1, NY-Y, CP-2, EBP20, and c-myb. These data provide the first characterization of the human Fas gene and insight into its regulatory region. 54 refs., 3 figs., 1 tab.« less

Associate Administrator, Robert Lightfoot address the Marshall Association.

NASA Image and Video Library

2015-07-28

NASA ASSOCIATE ADMINISTRATOR ROBERT LIGHTFOOT SHARED HIS PERSONAL REFLECTIONS ON LEADERSHIP WITH MARSHALL ASSOCIATION MEMBERS AND GUESTS DURING A LUNCHEON JULY 28 AT NASA’S MARSHALL SPACE FLIGHT CENTER.

Development of a Free-Electron Laser Center and Research in Medicine, Biology and Materials Science,

DTIC Science & Technology

1992-05-14

Elastin Production in Tissue Culture", Debra A.Gonzalez MD, David L. Zealear, PhD., J.M. Davidson, PhD., Robert H. Ossoff, MD, DMD , August 1990...Otolaryngoloty-Head and Neck Surgery. K. "CO2 Laser Micromanipulator Parallax Error Resolved, Jay Werkhaven,MD, Jerri Tribble, and Robert H. Ossoff, MD, DMD ...of the Upper Aerodigestive Tract, Robert H. Ossoff, MD, DMD , Al Aly, MD, Nick Houchin, AAS, and Debra Gonzalez, MD, Vanderbilt University, Nashville

America’s last battles: Organizing brigades to win the peace lessons from East Timor, Afghanistan, and Iraq

DTIC Science & Technology

2004-06-17

Graduate Degree Programs Robert F. Baumann, Ph.D. The opinions and conclusions expressed herein are those of the student author and do not...primary research method this study will follow is the case study method as outlined in Robert K. Yin’s, Case Study Research: Design and Methods. By using...The method is also policy relevant as it generates lessons relevant to different situations. In Robert K. Yin’s words, “An important step . . . is the

Robert Halliday Gunning and the Victoria Jubilee prizes.

PubMed

Baillie, T W

2003-05-01

More than a century after the death of Robert Halliday Gunning, a large number of lectureships and prizes bearing his name continue to be awarded by scientific bodies and learned institutions in Scotland. Most of these awards were endowed in HM Queen Victoria s Jubilee year (1887-88) and bear the additional qualification 'Victoria Jubilee'. An account of the life of Robert Gunning and his various endowments is complemented by an analysis of the factors which determined the nature of his benefactions.

Environmental Analysis of Lake Pontchartrain, Louisiana, Its Surrounding Wetlands, and Selected Land Uses. Volume 1.

DTIC Science & Technology

1980-02-01

M. Darnell,* Richard W. Heard,* Robert C. Cashner,* and Olivia House* e Graduate Modeling Robert E. Hinchee and Linda A. Deegan Students Grassbeds...James H. Stone, B. T. Gael, Linda A. Deegan , Robert E. Hinchee, John W. Day, Jr., Leonard M. Bahr, Jr., and R. E. Turner R. C. Cashner is affiliated with...Sciences Linda A. Deegan , Graduate Assistant David D. Dow, Research Associate III Nancy A. Drummond, Graduate Assistant Marion Fannaly, Research Associate

Two autographs: Cecile Dewitt and Robert Hawking (for Steven Hawking)

NASA Astrophysics Data System (ADS)

Gaina, Alex

2007-12-01

Two autographs given to author by professor Cecile Dewitt and Robert Hawking (the son of Steven Hawking for his father) in 1987 during the Quantum Gravity Seminar in Moscow are presented. The first was given during a visit to Physical Institute of the Academy of sciences of the USSR, where a seminar held in the Theoretical department. the second was given during a lunch with Steven Hawking, Andrei Linde and Robert Hawking at the 2-nd floor of the Conference floor.

Group for High Resolution Sea Surface Temperature (GHRSST) Analysis Fields Inter-Comparisons. Part 1: A GHRSST Multi-Product Ensemble (GMPE)

DTIC Science & Technology

2012-05-02

Le Borgne, P., Poulter, D., Vazquez-Cuervo, J., Armstrong, E., Beggs, H., Llewellyn - Jones , D., Minnett, P., Merchant, C., Evans, R., 2009. The GODAE...Donlon i, Chelle Gentemann j, Robert Grumbine k, Shiro Ishizaki l, Eileen Maturi b, Richard W. Reynoldsm, Jonah Roberts- Jones a a Met Office, Exeter...high-resolution sea surface temperature pilot project. Oceanography 22, 34–45. Donlon, C.J., Martin, M., Stark, J.D., Roberts- Jones , J., Fiedler, E

Investigation of the Numerical Methods of Finite Differences and Weighted Residuals for Solution of the Heat Equation.

DTIC Science & Technology

1982-03-01

OF FINITE DIFFERENCES AND WEIGHTED RESIDUALS FOR SOLUTION OF THE HEAT EQUATION a THESIS J’. AFIT/GNE/PH/81-7 *-.1 Robert Naegeli .. ....... J --aC t...Institute of Technology Air University in Partial Fulfillment of the a Requirements for the Degree of Master of Science by Robert E. Naegeli , M.S. Capt USAF...a time which proved to be one of great personal adjustment and turmoil. Robert E. Naegeli ii Contents Page Preface

Competent, Confident and Agile? A Study of the U.S. Army Leadership Requirements Model and its Application for U.S. Army Company Commanders

DTIC Science & Technology

2011-06-10

Thesis Committee Chair John M. Persyn, Ph.D. , Member LTC Eric K. Dunahee, M.S. , Member Robert D. Bloomquist, M.A...Accepted this 10th day of June 2011 by: , Director, Graduate Degree Programs Robert F. Baumann, Ph.D. The opinions and conclusions expressed...have been possible without the support of my committee, Dr. John M. Persyn, LTC Eric K. Dunahee and Mr. Robert D. Bloomquist. Thank you for your

7. Historic American Buildings Survey, Robert E. Cooper, Photographer January, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey, Robert E. Cooper, Photographer January, 1961 DEMOLITION, SHOWING STRUCTURAL ELEMENTS. - American Life Insurance Company Building, 330-336 Walnut Street, Philadelphia, Philadelphia County, PA

Official portrait of astronaut Robert C. Springer

NASA Technical Reports Server (NTRS)

1988-01-01

Official portrait of astronaut Robert C. Springer, United Stated Marine Corps (USMC) Colonel, member of Astronaut Class 9 (1980), and mission specialist. Springer wears launch and entry suit (LES) while holding helmet.

Association of American Indian Physicians

MedlinePlus

... Scholars Program This program of the Robert Wood Johnson Foundation is a leadership development opportunity for practitioners ... for Clinical Scholars program supported by Robert Wood Johnson Foundation will open in January 2018. https://t. ...

Astronaut Robert L. Crippen prepares for underwater training session

NASA Technical Reports Server (NTRS)

1983-01-01

Astronaut Robert L. Crippen, STS-7 crew commander, adjusts his extravehicular mobility unit's (EMU) gloves prior to donning his helmet for a training session in the weightless environment test facility (WETF).

78 FR 11090 - Flightcrew Member Duty and Rest Requirements; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-15

... this action, contact Dale E. Roberts, AFS-200, Flight Standards Service, Air Transportation Division...- 5749; email dale[email protected] . For legal questions concerning this action, contact Robert Frenzel...

6. Historic American Buildings Survey Robert W. Kerrigan, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey Robert W. Kerrigan, Photographer August 24, 1936 INTERIOR DETAIL WEST WALL OF SOCIAL HALL - Trocadero Inn, Sigmund Stern Grove, San Francisco, San Francisco County, CA

6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Watchman Robert 'Jerry' Jones at Camp Dyer. Photographer James Dix Schuyler, 1903. Source: Schuyler report. - Waddell Dam, On Agua Fria River, 35 miles northwest of Phoenix, Phoenix, Maricopa County, AZ

Peculiar Traits of Coarse AP (Briefing Charts)

DTIC Science & Technology

2014-12-01

coarse AP Bircumshaw, Newman Active centers are sources of AP decomposition gases AP low temperature decomposition (LTD) Most unstable AP particles ...delay before coarse AP ejection *Coarse AP particle flame retardancy 19 Air Force Research Laboratory Distribution A: Approved for public release...distribution unlimited. PA clearance #. Combustion bomb trials 2 AP phase change may enable coarse particle breakage Fractured coarse AP ejection agrees

Observation of Two-Dimensional Localized Jones-Roberts Solitons in Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Meyer, Nadine; Proud, Harry; Perea-Ortiz, Marisa; O'Neale, Charlotte; Baumert, Mathis; Holynski, Michael; Kronjäger, Jochen; Barontini, Giovanni; Bongs, Kai

2017-10-01

Jones-Roberts solitons are the only known class of stable dark solitonic solutions of the nonlinear Schrödinger equation in two and three dimensions. They feature a distinctive elongated elliptical shape that allows them to travel without change of form. By imprinting a triangular phase pattern, we experimentally generate two-dimensional Jones-Roberts solitons in a three-dimensional atomic Bose-Einstein condensate. We monitor their dynamics, observing that this kind of soliton is indeed not affected by dynamic (snaking) or thermodynamic instabilities, that instead make other classes of dark solitons unstable in dimensions higher than one. Our results confirm the prediction that Jones-Roberts solitons are stable solutions of the nonlinear Schrödinger equation and promote them for applications beyond matter wave physics, like energy and information transport in noisy and inhomogeneous environments.

Cognitive remediation therapy and cognitive behavioral therapy with an older adult with anorexia nervosa: A brief case report.

PubMed

Darcy, Alison M; Fitzpatrick, Kara K; Lock, James

2016-06-01

Cognitive remediation therapy represents a new approach to the treatment of anorexia nervosa (AN) emerging from research, suggesting that adults with chronic AN have specific neurocognitive inefficiencies. Specifically, adults with AN demonstrate an overly detailed cognitive processing bias (Roberts, Tchanturia, & Treasure, 2013) and difficulties shifting set quickly and efficiently (Roberts, Tchanturia, Stahl, Southgate, & Treasure, 2007). These characteristics manifest as rigid, rule-bound, and detail-focused cognitions, beliefs, and behaviors. Versions of these problems appear to persist after weight restoration (Tchanturia et al., 2004) and are observable in patient's healthy sisters (Roberts et al., 2013). Thus, central coherence difficulties and set-shifting problems have been proposed as endophenotypes and maintaining factors of AN (Roberts et al., 2013). (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Erratum: The Hubble Space Telescope Key Project on the Extragalactic Distance Scale. XXVIII. Combining the Constraints on the Hubble Constant

NASA Astrophysics Data System (ADS)

Mould, Jeremy R.; Huchra, John P.; Freedman, Wendy L.; Kennicutt, Robert C., Jr.; Ferrarese, Laura; Ford, Holland C.; Gibson, Brad K.; Graham, John A.; Hughes, Shaun M. G.; Illingworth, Garth D.; Kelson, Daniel D.; Macri, Lucas M.; Madore, Barry F.; Sakai, Shoko; Sebo, Kim M.; Silbermann, Nancy A.; Stetson, Peter B.

2000-12-01

In the article ``The Hubble Space Telescope Key Project on the Extragalactic Distance Scale. XXVIII. Combining the Constraints on the Hubble Constant'' (ApJ, 529, 786 [2000]), by Jeremy R. Mould, John P. Huchra, Wendy L. Freedman, Robert C. Kennicutt, Jr., Laura Ferrarese, Holland C. Ford, Brad K. Gibson, John A. Graham, Shaun M. G. Hughes, Garth D. Illingworth, Daniel D. Kelson, Lucas M. Macri, Barry F. Madore, Shoko Sakai, Kim M. Sebo, Nancy A. Silbermann, and Peter B. Stetson, some sign errors need to be corrected. 1. In equation (A2) the minus signs should be plus signs. The correct version is Vcosmic=VH+Vc,LG+Vin,Virgo+Vin,GA+Vin,Shap+... 2. In Table A1 the declination of the Great Attractor (GA) is -44°, and that of the Shapley supercluster is -31°, i.e., south declination, not north, as implied in the table. The first error is the authors' and the second occurred in the publication process. In both cases the computer code was correct, and the errors are in the published representation. None of the results presented in the paper are therefore affected in any way. The authors thank Dr. Jim Condon for pointing out the error in equation (A2)

Integration of new geologic mapping and satellite-derived quartz mapping yields insights into the structure of the Roberts Mountains allochthon applicable to assessments for concealed Carlin-type gold deposits

USGS Publications Warehouse

Holm-Denoma, Christopher S.; Hofstra, Albert H.; Rockwell, Barnaby W.; Noble, Paula J.

2012-01-01

Geologic mapping and remote sensing across north-central Nevada enable recognition of a thick sheet of Middle and Upper Ordovician Valmy Formation quartzite that structurally overlies folded and faulted Ordovician through Devonian stratigraphic units of the Roberts Mountains allochthon. In the northern Independence Mountains and nearby Double Mountain area, the Valmy Formation is in fault contact with Ordovician through Silurian, predominantly clastic, sedimentary rocks of the Roberts Mountains allochthon that were deformed prior to, or during, emplacement of the Valmy thrust sheet. Similar structural relations are recognized discontinuously for 200 kilometers along the strike of the Roberts Mountains allochthon in mapping guided by regional remote-sensing-based (ASTER) quartz maps. Overall thicknesses of deformed Roberts Mountains allochthon units between the base of the Valmy and the top of underlying carbonate rocks that host large Carlin-type gold deposits varies on the order of hundreds of meters but is not known to exceed 700 meters. The base of the Valmy thrust sheet is a complimentary datum in natural resource exploration and mineral resource assessment for concealed Carlin-type gold deposits.

Meet EPA Scientist Robert Devlin, Ph.D.

EPA Pesticide Factsheets

EPA scientist Dr. Robert Devlin's main research interest is understanding the health effects of air pollution. His research characterizes the effects that inhaled substances, such as air pollutants, have on human pulmonary and cardiovascular health

24. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 13, 1936 VIEW FROM RIGHT SIDE - SOUTH - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

43. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 GENERAL VIEW TOWARD FRONT ENTRANCE - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

31. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

31. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 DETAIL OF FONT (Original) - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

22. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo Taken: May 13, 1936 VIEW FROM EAST - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

44. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 COLUMN AND PULPIT DETAIL - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

45. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 COLUMN AND WINDOW DETAIL - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

21. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo Taken: May 14, 1936 VIEW FROM NORTH - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

ZERO-G - Crippen, Robert L.

NASA Image and Video Library

1979-04-03

Zero-gravity experiments in KC-135 conducted by John Young, Robert L. Crippen, Joseph Kerwin, and Margaret Seddon. 1. Kerwin, Joseph - Zero-G 2. Seddon, Margaret - Zero-G 3. Young, John - Zero-G 4. Aircraft - KC-135

U.S. Environmental Protection Agency's Robert S. Kerr Environmental Research Center, Ada, Oklahoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farrar-Nagy, S.; Voss, P.; Van Geet, O.

2006-10-01

U.S. EPA's Robert S. Kerr Environmental Research Center, Ada, Oklahoma, has reduced its annual energy consumption by 45% by upgrading its building mechanical system and incorporating renewable energy.

A concurrent resolution calling on the President and the allies of the United States to raise in all appropriate bilateral and multilateral fora the case of Robert Levinson at every opportunity, urging Iran to fulfill their promises of assistance to the family of Robert Levinson, and calling on Iran to share the results of its investigation into the disappearance of Robert Levinson with the Federal Bureau of Investigation.

THOMAS, 111th Congress

Rep. Wexler, Robert [D-FL-19

2009-02-03

Senate - 11/18/2009 Placed on Senate Legislative Calendar under General Orders. Calendar No. 214. (All Actions) Tracker: This bill has the status Agreed to in HouseHere are the steps for Status of Legislation:

Cultural Resources Survey and Testing Along Ditch 19 Dunklin and Stoddard Counties, Missouri

DTIC Science & Technology

1987-07-15

AD-A265 021 I/ A CULTURAL RESOURCES SURVEY AND TESTING (I ALONG DITCH 19 DUNKLIN AND STODDARD COUNTIES , MISSOURI by Kathryn A. King and * viy Robert...and Stoddard Counties , MO C 53-7103-7-545 6. AUTHOR(S) Kathryn A. King Robert H. Lafferty III 7. PERFORM•!NG ORGANIZATION NAME•S) AND ADDRESS’ES) 8...CULTURAL RESOURCES SURVEY AND TESTING ALONG DITCH 19 DUNKLIN AND STODDARD COUNTIES , MISSOURI by Kathryn A. King and Robert H. Lafferty III 1EL E C T

Promoting medical innovation while developing sound social and business policy: a conversation with Thomas G. Roberts. Interview by Barbara J. Culliton.

PubMed

Roberts, Thomas G

2008-01-01

The development of "targeted biologics" as cancer therapy has made the field ripe for investment from the private sector and is changing the face of cancer medicine, while also raising important policy concerns about price, profit, and continued innovation. In this interview Barbara Culliton talks with Thomas Roberts, who sees this world from a unique perspective. Roberts, an oncologist, has practiced at the Massachusetts General Hospital and is currently thinking about innovation as a hedge fund manager.

A Comparison of the Operational Art of George Gordon Meade and Robert Edward Lee during the Period June 1863, to March 1864.

DTIC Science & Technology

1988-03-29

PERIOD COVERED A Comparison of the Operational Art of George G. Meade and Robert E. Lee During the Period Jun 1 8 6 3 Indiv study project to March...publication until it has been cleared by the appropriate military Service er gover"uent aency. A Comparison Of The Operational Art Of George Gordon...and/or Dis Speclal;! Sp ABSTRACT AUTHOR: THOMAS A. GREEN, LTC, AV. TITLE: A Comparison of the Operational Art of George Gordon Meade and Robert Edward

Buzzard Island Dredged Material Beneficial Use Access Road, Upper Mississippi River, River Mile 349, Pool 20. General Design Memorandum and Environmental Assessment

DTIC Science & Technology

1988-06-01

contact the above number for more information. DOW E. PROUTY. PRESIDENT * ROBERT C. MESKIMEN , PRESIDENT-ELECT UO E I. S TH sl’w KENNETH W. MCNICHOLS...the Mississippi River. Cofesburg. Iowa Members of the Iowa Limestone Producers Association ROBERT C. MESKIMEN Marlin Marietta Aggregates very strongly...cc: Missouri DOC (Farabee, Dieffenbach) ITUW L7f DOW E. PROUTY. PRESIDENT 0 ROBERT C. MESKIMEN . PRESIDENT-ELECT I uSre r/m $111 KENNETH W. McNICHOLS

Index of National Aviation Facilities Experimental Center Technical Reports 1972-1977.

DTIC Science & Technology

1981-05-01

EVALUATION OF DIGITAL ALTIMETER SETTING INDICATORS Robert Frack , Ernest E. Sch’atter and Jack Bernstein Final, August 1975 55 P. (RD-75-81) (AD A013 994...runway would change the surface friction of that runway. The method consisted of jetting water at high velocity to hydraulically remove the rubber from...77-49 Erikson, Robert H. 74-17 Feher, Ray E. 76-53; 77-22 Fisher, Donald A. 74-24; 75-48; 76-15 Fisher, John J. 73-41 Frack , Robert 74-46 Gallagher

DefenseLink Special: Travels with Gates, January 2007

Science.gov Websites

that has been achieved there, said Defense Secretary Robert M. Gates. Story Gates to Build on Success , and Defense Secretary Robert M. Gates wants to build on those successes. Story Afghan Army Makes

47. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 DETAIL OF ARCH - RIGHT SIDE ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

48. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 DETAIL OF ARCH - RIGHT SIDE ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

50. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

50. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 15, 1936 DETAIL OF SMALL CHAPEL (Not original) - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

46. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. Historic American Buildings Survey Robert W. Kerrigan, Photographer Photo Taken: May 14, 1936 DETAIL OF ARCH LEFT SIDE - ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

23. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 GENERAL VIEW FROM LEFT SIDE - WEST - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

42. Historic American Buildings Survey Robert W. Kerrigan Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Historic American Buildings Survey Robert W. Kerrigan - Photographer Photo Taken: May 14, 1936 GENERAL VIEW OF INTERIOR - TOWARD ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

Modernizing the Military Retirement System

DTIC Science & Technology

2011-05-01

Patrick Gross, David Langstaff, Philip Odeen, Mark Ronald, Robert Stein, and Jack Zoeller. Catherine Whittington served as the Board Staff Analyst...Chair) Patrick Gross David Langstaff Philip Odeen Mark Ronald Robert Stein Jack Zoeller DBB Staff Analyst Catherine Whittington Methodology

33. Historic American Buildings Survey Robert W. Kerrigan, Photographer Dec. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. Historic American Buildings Survey Robert W. Kerrigan, Photographer Dec. 11, 1936 MONUMENT IN OLD CEMETERY (THE OLDEST MARKED GRAVE) - Mission San Francisco de Asis, Mission & Sixteenth Streets, San Francisco, San Francisco County, CA

Total Army Analysis Supporting Maximization of National Resources

DTIC Science & Technology

2013-03-01

Robert M. Mundell Department of Command Leadership and Management 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY...Colonel Robert M. Mundell Department of Command Leadership and Management Project Adviser This manuscript is submitted in partial fulfillment

Acute Pancreatitis and Use of Pancreatitis-Associated Drugs: A 10-Year Population-Based Cohort Study.

PubMed

Bertilsson, Sara; Kalaitzakis, Evangelos

2015-10-01

To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectively identified. Data regarding AP etiology, severity, and recurrence and use of AP-associated drugs were extracted from medical records. Drugs were classified according to an evidence-based classification system. Annual drug sales data were obtained from the Swedish drug administration service. Overall, 1457 cases of incident AP were identified. Acute pancreatitis-associated drug users increased from 32% in 2003 to 51% in 2012, reflecting increasing user rates in the general population. The incidence of AP increased during the study period but was not related to AP-associated drug user rates (P > 0.05). Recurrent AP occurred in 23% but was unrelated to AP-associated drug use (P > 0.05). In logistic regression analysis, after adjustment for comorbidity, AP-associated drug use was not related to AP severity (P > 0.05). Use of AP-associated drugs is increasingly frequent in patients with AP. However, it does not have any major impact on the observed epidemiological changes in occurrence, severity, or recurrence of AP.

Effect of clothing type on validity of air-displacement plethysmography.

PubMed

King, George A; Fulkerson, Bethany; Evans, Michael J; Moreau, Kerrie L; McLaughlin, James E; Thompson, Dixie L

2006-02-01

The purpose of the study was to evaluate the validity of an air-displacement plethysmography system (AP) within the general population, while wearing (1) a racing-type swimsuit (AP(SS)) and (2) participant's personal undergarments (AP(UG)), against hydrodensitometry (HW). Fifty women and 50 men were measured for body volume, density, and fat percentage by HW and compared with AP(SS) and AP(UG). For women, AP(UG) and AP(SS) were similar, although significant differences (p < 0.001) were observed between AP(UG) and HW and between AP(SS) and HW. For men, there was no significant difference between AP(UG) and HW; however, significant differences (P < or = 0.01) were found between AP(UG) and AP(SS) and between AP(SS) and HW. The small discrepancy in measured values between AP and HW are within the measurement error for the instrumentation and these data support the use of AP for determination of body composition in adults across a wide range of body size (body mass index [BMI] 17.7-35.2 kg.m(-2)) and age (18-57 y). Participants' personal undergarments provide a practical alternative to a spandex swimsuit when measuring body composition by AP in women but not in men.

Purification, characterisation and protective effects of polysaccharides from alfalfa on hepatocytes.

PubMed

Wang, Shaopu; Dong, Xiaofang; Ma, Hao; Cui, Yaoming; Tong, Jianming

2014-11-04

The objective of this study was to determine the preliminary characteristics and protective effects of alfalfa polysaccharides (APS) on hepatocytes in vitro. The crude APS was purified by DEAE-cellulose and Sephadex G-100 chromatography, resulting in the four purified fractions: APS-1, APS-2, APS-3 and APS-4. The results indicated that APS-3 had higher carbohydrate and uronic acid contents and that APS-4 had a more complicated monosaccharide composition compared to the other purified fractions. The average molecular weights of APS-1, APS-2, APS-3 and APS-4 were 48,536, 6,221, 66,559 and 13,076 Da, respectively. Furthermore, APS (crude and its purified fractions) restored the activities of antioxidant enzymes and increased the total antioxidant capacity of hepatocytes subjected to H2O2-induced oxidative stress. Furthermore, APS treatment counteracted the increases in lactic dehydrogenase and malonaldehyde in the culture supernatant. These results clearly demonstrate that APS possesses a protective effect against oxidative injury in hepatocytes. Copyright © 2014 Elsevier Ltd. All rights reserved.

US EPA Freedom of Information Act Workgroup Report: Prepared for Robert Perciasepe, Deputy Administrator

EPA Pesticide Factsheets

Deputy Administrator Robert Perciasepe requested a workgroup develop options and recommendations to ensure that the Agency’s administration of FOIA and related processes are effective, efficient and promote open government and transparency policies.

Siegfried Receives 2006 Robert C. Cowen Award

NASA Astrophysics Data System (ADS)

Siegfried, Tom

2006-07-01

Tom Siegfried received the 2006 Robert C. Cowen Award for Sustained Achievement in ScienceJournalism at the Joint Assembly Honors Ceremony, which was held on 25 May 2006 inBaltimore, Md. The award honors lifetime achievement in science journalism.

Developing Strategic Leader Competencies in Today’s Junior Officer Corps

DTIC Science & Technology

2013-03-01

AND ADDRESS(ES) Colonel Robert M. Mundell Department of Command, Leadership, and Management 8. PERFORMING ORGANIZATION REPORT NUMBER 9...O’Donnell United States Army Colonel Robert M. Mundell Department of Command, Leadership, and Management Project Adviser

Overexpression of two PsnAP1 genes from Populus simonii × P. nigra causes early flowering in transgenic tobacco and Arabidopsis.

PubMed

Zheng, Tangchun; Li, Shuang; Zang, Lina; Dai, Lijuan; Yang, Chuanping; Qu, Guan-Zheng

2014-01-01

In Arabidopsis, AP1 is a floral meristem identity gene and plays an important role in floral organ development. In this study, PsnAP1-1 and PsnAP1-2 were isolated from the male reproductive buds of poplar (Populus simonii × P. nigra), which are the orthologs of AP1 in Arabidopsis, by sequence analysis. Northern blot and qRT-PCR analysis showed that PsnAP1-1 and PsnAP1-2 exhibited high expression level in early inflorescence development of poplar. Subcellular localization showed the PsnAP1-1 and PsnAP1-2 proteins are localized in the nucleus. Overexpression of PsnAP1-1 and PsnAP1-2 in tobacco under the control of a CaMV 35S promoter significantly enhanced early flowering. These transgenic plants also showed much earlier stem initiation and higher rates of photosynthesis than did wild-type tobacco. qRT-PCR analysis further indicated that overexpression of PsnAP1-1 and PsnAP1-2 resulted in up-regulation of genes related to flowering, such as NtMADS4, NtMADS5 and NtMADS11. Overexpression of PsnAP1-1 and PsnAP1-2 in Arabidopsis also induced early flowering, but did not complement the ap1-10 floral morphology to any noticeable extent. This study indicates that PsnAP1-1 and PsnAP1-2 play a role in floral transition of poplar.

Organization, regulatory sequences, and alternatively spliced transcripts of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) gene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sampaio, S.O.; Mei, C.; Butcher, E.C.

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking. MAdCAM-1 is a multifunctional type I transmembrane adhesion molecule comprising two distal Ig domains involved in {alpha}4{beta}7 integrin binding, a mucin-like region able to display L-selectin-binding carbohydrates, and a membrane-proximal Ig domain homologous to IgA. We show in this work that the MAdCAM-1 gene is located on chromosome 10 and contains five exons. The signal peptide and each one of the three Ig domains are encoded by a distinct exon, whereasmore » the transmembrane, cytoplasmic tail, and 3{prime}-untranslated region of MAdCAM-1 are combined on a single exon. The mucin-like region and the third Ig domain are encoded together on exon 4. An alternatively spliced MAdCAM-1 mRNA is identified that lacks the mucin/IgA-homologous exon 4-encoded sequences. This short variant of MAdCAM-1 may be specialized to support {alpha}4{beta}7-dependent adhesion strengthening, independent of carbohydrate-presenting function. Sequences 5{prime} of the transcription start site include tandem nuclear factor-KB sites; AP-1, AP-2, and signal peptide-1 binding sites; and an estrogen response element. Our findings reinforce the correspondence between the multidomain structure and versatile functions of this vascular addressin, and suggest an additional level of regulation of carbohydrate-presenting capability, and thus of its importance in lectin-mediated vs. {alpha}4{beta}7-dependent adhesive events in lymphocyte trafficking. 46 refs., 6 figs., 1 tab.« less

P alpha-chiral phosphorothioate analogues of bis(5'-adenosyl)tetraphosphate (Ap4A); their enzymatic synthesis and degradation.

PubMed Central

Lazewska, D; Guranowski, A

1990-01-01

Synthesis of Sp and Rp diastereomers of Ap4A alpha S has been characterized in two enzymatic systems, the lysyl-tRNA synthetase from Escherichia coli and the Ap4A alpha, beta-phosphorylase from Saccharomyces cerevisiae. The synthetase was able to use both (Sp)ATP alpha S and (Rp)ATP alpha S as acceptors of adenylate thus yielding corresponding monothioanalogues of Ap4A,(Sp) Ap4A alpha S and (Rp)Ap4A alpha S. No dithiophosphate analogue was formed. Relative synthetase velocities of the formation of Ap4A,(Sp) Ap4A alpha S and (Rp)Ap4A alpha S were 1:0.38:0.15, and the computed Km values for (Sp)ATP alpha S and (Rp)ATP alpha S were 0.48 and 1.34 mM, respectively. The yeast Ap4A phosphorylase synthesized (Sp)Ap4A alpha S and (Rp)Ap4A alpha S using adenosine 5'-phosphosulfate (APS) as source of adenylate. The adenylate was accepted by corresponding thioanalogues of ATP. In that system, relative velocities of Ap4A, (Sp)Ap4A alpha S and (Rp)Ap4A alpha S formation were 1:0.15:0.60. The two isomeric phosphorothioate analogues of Ap4A were tested as substrates for the following specific Ap4A-degrading enzymes: (asymmetrical) Ap4A hydrolase (EC 3.6.1.17) from yellow lupin (Lupinus luteus) seeds hydrolyzed each of the analogues to AMP and the corresponding isomer of ATP alpha S; (symmetrical) Ap4A hydrolase (EC 3.6.1.41) from E. coli produced ADP and the corresponding diastereomer of ADP alpha S; and Ap4A phosphorylase (EC 2.7.7.53) from S. cerevisiae cleaved the Rp isomer only at the unmodified end yielding ADP and (Rp)ATP alpha S whereas the Sp isomer was degraded non-specifically yielding a mixture of ADP, (Sp)ADP alpha S, ATP and (Sp)ATP alpha S. For all the Ap4A-degrading enzymes, the Rp isomer of Ap4A alpha S appeared to be a better substrate than its Sp counterpart; stereoselectivity of the three enzymes for the Ap4A alpha S diastereomers is 51, 6 and 2.5, respectively. Basic kinetic parameters of the degradation reactions are presented and structural requirements of the Ap4A-metabolizing enzymes with respect to the potential substrates modified at the Ap4A-P alpha are discussed. PMID:2172926

75 FR 57920 - Kerr-Philpott System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... schedules VA-1-B, VA-2-B, VA-3- B, VA-4-B, CP&L-1-B, CP&L-2-B, CP&L-3-B, CP&L-4-B, AP-1-B, AP-2-B, AP- 3-B..., CP&L-1-A, CP&L-2-A, CP&L-3-A, CP&L-4-A, AP-1-A, AP-2-A, AP-3-A, AP-4-A, NC-1-A, and Replacement-2... Schedules VA-1-A, VA-2-A, VA-3-A, VA-4-A, CP&L-1- A, CP&L-2-A, CP&L-3-A, CP&L-4-A, AP-1-A, AP-2-A, AP-3-A...

Statistical Evaluation of Airport Pavement Condition Survey Data for Washington, Oregon, and Idaho

DTIC Science & Technology

1988-01-01

21...COUNTY SQUIRE AIRPARK, OREGON 12 70 22...FLORENCE MUNICIPAL AP, OREGON 3 95 23...HERMISTON MUNICIPAL AP, OREGON 11 87 24...HOOD RIVER AP, OREGON...12 87 33...OROFINO MUNICIPAL AP, IDAHO 17 81 34...PRIEST RIVER MUNICIPAL AP, IDAHO 11 86 *NUgU**MmUU~tNUINNNNNNNffWUU0W NUU EU*UI** **-28 -28- TABLE 3...3 88 8...BAKER MUNICIPAL AP, OREGON 3 90 9...BEND MUNICIPAL AP, OREGON 9 89 10..CRESWELL MUNICIPAL AP, OREGON 1 98 11..HOOD RIVER AP, OREGON 1 96 12

Selected Proceedings from the Texas Foreign Language Education Conference 2001.

ERIC Educational Resources Information Center

Luke, Christopher, Ed.

2001-01-01

This collection of papers includes: "Language Learning Motivation: The Student, the Teacher, and the Researcher" (Robert C. Gardner); "The Self-Reported Perspectives Regarding Academic Writing among Taiwanese Graduate Students Specializing in TEFL" (Robert Johanson); "Contradictions, Appropriation, and Transformation: An…

A Constructive Induction Approach to Computer Immunology

DTIC Science & Technology

1999-03-01

LVM98] Lamont, Gary B., David A. Van Veldhuizen , and Robert E Marmelstein, A Distributed Architecture for a Self-Adaptive Computer Virus...Artificial Intelligence, Herndon, VA, 1995. [MVL98] Marmelstein, Robert E., David A. Van Veldhuizen , and Gary B. Lamont. Modeling & Analysis

75 FR 72935 - Apricots Grown in Designated Counties in Washington; Temporary Relaxation of the Minimum Grade...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... FURTHER INFORMATION CONTACT: Robert J. Curry or Gary D. Olson, Northwest Marketing Field Office, Marketing...: (503) 326-7440, or E-mail: Robert.Curry@ams.usda.gov or [email protected] . Small businesses may...

78 FR 56227 - Issuance of an Experimental Use Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... experimental use permit (EUP) to the pesticide applicant, Robert I. Rose, Ph.D., on behalf of James Mains, Ph.D.... Issuance. Robert I. Rose, Ph.D., on behalf of James Mains, Ph.D., Mosquito Mate, Inc., 1122 Oak Hill Drive...

Balancing Petroleum Force Structure/Capabilities between Active and Reserve Components

DTIC Science & Technology

2013-03-01

ORGANIZATION NAME(S) AND ADDRESS(ES) Colonel Robert M. Mundell Department of Command, Leadership, and Management 8. PERFORMING ORGANIZATION REPORT...Colonel Kenneth R. Hook United States Army Colonel Robert M. Mundell Department of Command, Leadership, and Management Project

Max Weber and Robert Michels.

ERIC Educational Resources Information Center

Scaff, Lawrence A.

1981-01-01

This paper investigates the unique intellectual partnership of Max Weber and Robert Michels, with particular emphasis on Weber's influence on Michel's inquiry into the sociology of parties and organization. Concludes with an evaluation of the import of Weber's critique of Michels' work. (DB)

75 FR 61985 - Airworthiness Directives; Boeing Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747-200F, 747...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... docket shortly after receipt. FOR FURTHER INFORMATION CONTACT: Robert Kaufman, Aerospace Engineer, Cabin.... Send information to Robert Kaufman, Aerospace Engineer, Cabin Safety and Environmental Systems Branch...

78 FR 45548 - South Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance...; 97.048, Disaster Housing Assistance to [[Page 45549

Diadenosine polyphosphates Ap3A and Ap4A, but not Ap5A or Ap6A, induce proliferation of vascular smooth muscle cells.

PubMed

Bobbert, Peter; Schlüter, Hartmut; Schultheiss, Heinz Peter; Reusch, Hans Peter

2008-05-15

Depending on the number of phosphate groups, diadenosine polyphosphates (ApnA, Ap3A, Ap4A, Ap5A and Ap6A) differ in properties such as proliferation, apoptosis, vasoconstriction and vasodilatation of vascular smooth muscle cells (VSMCs). Possible signaling pathways leading to effects such as proliferation are still unknown. This study examined the proliferative effects of diadenosine polyphosphates on VSMCs and their intracellular pathways. Proliferation of VSMCs was measured by the cell count and [(3)H] thymidine incorporation. Phosphorylation of the MAP kinases ERK1/2 was determined by Western blotting. Single-cell [Ca(2+)](i) measurements were done to determine the influence of [Ca(2+)](i) on intracellular signaling. Stress fiber formation was assessed by fluorescence microscopy to detect an influence of G alpha(12). Ap3A and Ap4A, but not Ap5A or Ap6A, were shown to increase proliferation of VSMCs by activating P2Y receptors, which leads to stimulation of the Ras-Raf-MEK-ERK1/2 cascade. Ap3A- and Ap4A-induced activation of the MAP kinases ERK1/2 was dependent on a signaling pathway that included the EGF receptor, PKC, PLCbeta and the increase of [Ca(2+)](i). In conclusion, Ap3A and Ap4A, but not Ap5A or Ap6A, induce proliferation of VSMCs by a signaling pathway that begins with activation of P2Y receptors and leads to stimulation of the MAP kinases ERK1/2.

Overexpression of Two PsnAP1 Genes from Populus simonii × P. nigra Causes Early Flowering in Transgenic Tobacco and Arabidopsis

PubMed Central

Zheng, Tangchun; Li, Shuang; Zang, Lina; Dai, Lijuan; Yang, Chuanping; Qu, Guan-Zheng

2014-01-01

In Arabidopsis, AP1 is a floral meristem identity gene and plays an important role in floral organ development. In this study, PsnAP1-1 and PsnAP1-2 were isolated from the male reproductive buds of poplar (Populus simonii × P. nigra), which are the orthologs of AP1 in Arabidopsis, by sequence analysis. Northern blot and qRT-PCR analysis showed that PsnAP1-1 and PsnAP1-2 exhibited high expression level in early inflorescence development of poplar. Subcellular localization showed the PsnAP1-1 and PsnAP1-2 proteins are localized in the nucleus. Overexpression of PsnAP1-1 and PsnAP1-2 in tobacco under the control of a CaMV 35S promoter significantly enhanced early flowering. These transgenic plants also showed much earlier stem initiation and higher rates of photosynthesis than did wild-type tobacco. qRT-PCR analysis further indicated that overexpression of PsnAP1-1 and PsnAP1-2 resulted in up-regulation of genes related to flowering, such as NtMADS4, NtMADS5 and NtMADS11. Overexpression of PsnAP1-1 and PsnAP1-2 in Arabidopsis also induced early flowering, but did not complement the ap1-10 floral morphology to any noticeable extent. This study indicates that PsnAP1-1 and PsnAP1-2 play a role in floral transition of poplar. PMID:25360739

ParamAP: Standardized Parameterization of Sinoatrial Node Myocyte Action Potentials.

PubMed

Rickert, Christian; Proenza, Catherine

2017-08-22

Sinoatrial node myocytes act as cardiac pacemaker cells by generating spontaneous action potentials (APs). Much information is encoded in sinoatrial AP waveforms, but both the analysis and the comparison of AP parameters between studies is hindered by the lack of standardized parameter definitions and the absence of automated analysis tools. Here we introduce ParamAP, a standalone cross-platform computational tool that uses a template-free detection algorithm to automatically identify and parameterize APs from text input files. ParamAP employs a graphic user interface with automatic and user-customizable input modes, and it outputs data files in text and PDF formats. ParamAP returns a total of 16 AP waveform parameters including time intervals such as the AP duration, membrane potentials such as the maximum diastolic potential, and rates of change of the membrane potential such as the diastolic depolarization rate. ParamAP provides a robust AP detection algorithm in combination with a standardized AP parameter analysis over a wide range of AP waveforms and firing rates, owing in part to the use of an iterative algorithm for the determination of the threshold potential and the diastolic depolarization rate that is independent of the maximum upstroke velocity, a parameter that can vary significantly among sinoatrial APs. Because ParamAP is implemented in Python 3, it is also highly customizable and extensible. In conclusion, ParamAP is a powerful computational tool that facilitates quantitative analysis and enables comparison of sinoatrial APs by standardizing parameter definitions and providing an automated work flow. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Ap4A induces apoptosis in human cultured cells.

PubMed

Vartanian, A; Alexandrov, I; Prudowski, I; McLennan, A; Kisselev, L

1999-07-30

Diadenosine oligophosphates (Ap(n)A) have been proposed as intracellular and extracellular signaling molecules in animal cells. The ratio of diadenosine 5',5'''-P1,P3-triphosphate to diadenosine 5',5'''-P1,P4-tetraphosphate (Ap3A/Ap4A) is sensitive to the cellular status and alters when cultured cells undergo differentiation or are treated with interferons. In cells undergoing apoptosis induced by DNA topoisomerase II inhibitor VP16, the concentration of Ap3A decreases significantly while that of Ap4A increases. Here, we have examined the effects of exogenously added Ap3A and Ap4A on apoptosis and morphological differentiation. Penetration of Ap(n)A into cells was achieved by cold shock. Ap4A at 10 microM induced programmed cell death in human HL60, U937 and Jurkat cells and mouse VMRO cells and this effect appeared to require Ap4A breakdown as hydrolysis-resistant analogues of Ap4A were inactive. On its own, Ap3A induced neither apoptosis nor cell differentiation but did display strong synergism with the protein kinase C activators 12-deoxyphorbol-13-O-phenylacetate and 12-deoxyphorbol-13-O-phenylacetate-20-acetate in inducing differentiation of HL60 cells. We propose that Ap4A and Ap3A are physiological antagonists in determination of the cellular status: Ap4A induces apoptosis whereas Ap3A is a co-inductor of differentiation. In both cases, the mechanism of signal transduction remains unknown.

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

PubMed Central

Sitaram, Anand; Dennis, Megan K.; Chaudhuri, Rittik; De Jesus-Rojas, Wilfredo; Tenza, Danièle; Setty, Subba Rao Gangi; Wood, Christopher S.; Sviderskaya, Elena V.; Bennett, Dorothy C.; Raposo, Graça; Bonifacino, Juan S.; Marks, Michael S.

2012-01-01

Cell types that generate unique lysosome-related organelles (LROs), such as melanosomes in melanocytes, populate nascent LROs with cargoes that are diverted from endosomes. Cargo sorting toward melanosomes correlates with binding via cytoplasmically exposed sorting signals to either heterotetrameric adaptor AP-1 or AP-3. Some cargoes bind both adaptors, but the relative contribution of each adaptor to cargo recognition and their functional interactions with other effectors during transport to melanosomes are not clear. Here we exploit targeted mutagenesis of the acidic dileucine–based sorting signal in the pigment cell–specific protein OCA2 to dissect the relative roles of AP-1 and AP-3 in transport to melanosomes. We show that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position within the cytoplasmic domain. Mutants that preferentially bound either AP-1 or AP-3 each trafficked toward melanosomes and functionally complemented OCA2 deficiency, but AP-3 binding was necessary for steady-state melanosome localization. Unlike tyrosinase, which also engages AP-3 for optimal melanosomal delivery, both AP-1– and AP-3–favoring OCA2 variants required BLOC-1 for melanosomal transport. These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs. PMID:22718909

NASA Acting Administrator Robert Lightfoot All Hands

NASA Image and Video Library

2017-08-15

At NASA's Kennedy Space Center in Florida, agency Acting Administrator Robert Lightfoot and Deputy Associate Administrator Lesa Roe speak to employees during a town hall meeting in the conference room of Operations Support Building II. During the gathering, they updated progress on NASA programs.

Q & A with Ed Tech Leaders: Interview with Robert Talbert

ERIC Educational Resources Information Center

Shaughnessy, Michael F.; Yan, Juchao

2015-01-01

In this regular feature of "Educational Technology," Michael F. Shaughnessy and Juchao Yan present their interview with Robert Talbert, Associate Professor, Mathematics Department, Grand Valley State University, Allendale, Michigan. Their interview centered around thirteen questions that professor Talbert provided enlightening responds…

Morchella MLST database

USDA-ARS?s Scientific Manuscript database

Welcome to the Morchella MLST database. This dedicated database was set up at the CBS-KNAW Biodiversity Center by Vincent Robert in February 2012, using BioloMICS software (Robert et al., 2011), to facilitate DNA sequence-based identifications of Morchella species via the Internet. The current datab...

Mission, Science, and Race in South Africa; AW Roberts of Lovedale 1883-1938

NASA Astrophysics Data System (ADS)

Glass, I.S.

2016-02-01

Book Review: Biography of Alexander William Roberts. Noted educator, variable star observer and politician who represented South African "natives" in the parliament of the Union of South Africa at a time when they had no other representation.

76 FR 62085 - Pennsylvania; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... severity and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief....046, Fire Management Assistance Grant; [[Page 62086

Robert Frost and the Poetry of Physics.

ERIC Educational Resources Information Center

Coletta, W. John; Tamres, David H.

1992-01-01

Examines five poems by Robert Frost that illustrate Frost's interest in science. The poems include allusions to renowned physicists, metaphoric descriptions of some famous physics experiments, explorations of complementarity as enunciated by Bohr, and poetic formulations of Heisenberg's uncertainty principle. (20 references) (MDH)

2. Historic American Buildings Survey Robert J. Kelley, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Robert J. Kelley, Photographer May 1958 LOOKING NORTH - SHOWS SOUTH ELEVATION, MAIN HOUSE, ROOF OF NORTH ELEVATION AND WEST ELEVATION, WHOSE ROOF WAS RAISED IN RECENT TIMES - Burbank-Hatheway House, Main Street, Suffield, Hartford County, CT

Diadenosine tetraphosphate (Ap4A) and triphosphate (Ap3A) signaling of human sperm motility.

PubMed

Chan, P J; Su, B C; Tredway, D R

1991-01-01

The ubiquitous dinucleotide polyphosphate, diadenosine tetraphosphate (Ap4A), has been shown to be a signal molecule for DNA replication in mammalian cells. In this study, Ap4A and a related compound, diadenosine triphosphate (Ap3A), were tested for possible signaling functions in human spermatozoa. A computerized automated semen analyzer was used to detect changes in spermatozoa motility parameters. Cryopreserved-thawed donor spermatozoa were washed and incubated in 0.1 mM Ap4A, 0.1 mM Ap3A, or control medium. The data indicated that both Ap4A and Ap3A decreased the percentage of motile spermatozoa after 4 or more hours of incubation in vitro. The two dinucleotide polyphosphates caused an increase in the amplitude of lateral spermatozoa head displacement parameter only at the start of incubation. The other spermatozoa kinematic parameters were unaffected. No opposing ying-yang dual actions of Ap4A to Ap3A were seen. From the results, Ap4A and Ap3A were observed to be potential inhibitory signals of spermatozoa motility after prolonged exposure.

Diadenosine tetra- and pentaphosphates affect contractility and bioelectrical activity in the rat heart via P2 purinergic receptors.

PubMed

Pustovit, Ksenia B; Kuzmin, Vladislav S; Abramochkin, Denis V

2016-03-01

Diadenosine polyphosphates (Ap(n)As) are endogenously produced molecules which have been identified in various tissues of mammalian organism, including myocardium. Ap(n)As contribute to the blood clotting and are also widely accepted as regulators of blood vascular tone. Physiological role of Ap(n)As in cardiac muscle has not been completely elucidated. The present study aimed to investigate the effects of diadenosine tetra- (Ap4A) and penta- (Ap5A) polyphosphates on contractile function and action potential (AP) waveform in rat supraventricular and ventricular myocardium. We have also demonstrated the effects of A4pA and Ap5A in myocardial sleeves of pulmonary veins (PVs), which play a crucial role in genesis of atrial fibrillation. APs were recorded with glass microelectrodes in multicellular myocardial preparations. Contractile activity was measured in isolated Langendorff-perfused rat hearts. Both Ap4A and Ap5A significantly reduced contractility of isolated Langendorff-perfused heart and produced significant reduction of AP duration in left and right auricle, interatrial septum, and especially in right ventricular wall myocardium. Ap(n)As also shortened APs in rat pulmonary veins and therefore may be considered as potential proarrhythmic factors. Cardiotropic effects of Ap4A and Ap5A were strongly antagonized by selective blockers of P2 purine receptors suramin and pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS), while P1 blocker DPCPX was not effective. We conclude that Ap(n)As may be considered as new class of endogenous cardioinhibitory compounds. P2 purine receptors play the central role in mediation of Ap4A and Ap5A inhibitory effects on electrical and contractile activity in different regions of the rat heart.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Descartes, M.; Longshore, J.W.; Crawford, E.

We report an infant with double trisomy 48,XXX,+18, who also displayed features of Roberts syndrome. All previously published cases with similar double trisomy have presented with features of trisomy 18 syndrome. The chromosome analysis done at birth revealed the double trisomy; parental chromosomes were normal. The proband presented with microbrachycephaly, unilateral cleft lip and palate, choanal atresia, midfacial capillary hemanioma, thin nares, shallow orbits, malformed ears, sparse hair, hypomelia of the upper limbs, rocker-bottom feet, auricular septal defect and agenesis of the corpus callosum. Characteristic features of Roberts syndrome included hypomelia, midfacial defects, and severe growth deficiency. Among the manymore » different features reported in the literature for patients with trisomy 18 syndrome, the most consistent were growth deficiency, clenched fingers and congenital heart defects (e.g. VSD, ASD, PDA). Although some of our patient`s features such as cleft lip and cleft palate, low-set malformed ears, ASD, defects of the corpus callosum, choanal atresia, radial aplasia could also be seen in trisomy 18 syndrome (in 10-50% of the cases), her phenotype was more typical of Roberts syndrome because of symmetrical hypomelia and midfacial defects. Our patient`s chromosomes did not show premature separation of centromeric heterochromatin, a feature reported to occur in approximately one-half of individuals with Roberts syndrome. Sporadic aneuploidy involving different chromosomes has been found in lymphocyte cultures from some Roberts syndrome patients and is considered by some authors as a mitotic mutant. This aneuploidy is most likely to be chromosome gain. The simultaneous occurrence of trisomy X and 18 is extremely rare with only 11 cases having been reported in the literature. Our patient is unique since she has the double trisomy in addition to the characteristic features of Roberts syndrome.« less

Effects of the ultra-high pressure on structure and α-glucosidase inhibition of polysaccharide from Astragalus.

PubMed

Zhu, Zhen-Yuan; Luo, You; Dong, Guo-Ling; Ren, Yuan-Yuan; Chen, Li-Jing; Guo, Ming-Zhu; Wang, Xiao-Ting; Yang, Xue-Ying; Zhang, Yongmin

2016-06-01

A novel homogeneous polysaccharide fraction (APS) was extracted from Astragalus by hot water and purified by Sephadex G-100 and G-75 column. Its molecular weight was 693kDa. APS and APS with ultra-high pressure treatment exhibited significant inhibitory abilities on a-glucosidase, inhibition rate from high to low in order was 400MPa-APS, 300MPa-APS, 500MPa-APS and APS. The inhibition ​percentage of 400MPa-APS (1.5mg/mL) was 49% (max.). This suggested that the inhibitory activity of APS on a-glucosidase was improved by ultra-high pressure treatment. FT-IR, SEM, CD spectra, atomic force microscope and Congo red test analysis of APS and 400MPa-APS showed ultra-high pressure treatment didn't change the preliminary structure but had an effect on its advanced structure. Copyright © 2016 Elsevier B.V. All rights reserved.

Almost All Antipsychotics Result in Weight Gain: A Meta-Analysis

PubMed Central

Bak, Maarten; Fransen, Annemarie; Janssen, Jouke; van Os, Jim; Drukker, Marjan

2014-01-01

Introduction Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses generally are restricted to second generation antipsychotics (SGA) and do not stratify for duration of AP use. It is hypothesised that patients gain more weight if duration of AP use is longer. Method A meta-analysis was conducted of clinical trials of AP that reported weight change. Outcome measures were body weight change, change in BMI and clinically relevant weight change (7% weight gain or loss). Duration of AP-use was stratified as follows: ≤6 weeks, 6–16 weeks, 16–38 weeks and >38 weeks. Forest plots stratified by AP as well as by duration of use were generated and results were summarised in figures. Results 307 articles met inclusion criteria. The majority were AP switch studies. Almost all AP showed a degree of weight gain after prolonged use, except for amisulpride, aripiprazole and ziprasidone, for which prolonged exposure resulted in negligible weight change. The level of weight gain per AP varied from discrete to severe. Contrary to expectations, switch of AP did not result in weight loss for amisulpride, aripiprazole or ziprasidone. In AP-naive patients, weight gain was much more pronounced for all AP. Conclusion Given prolonged exposure, virtually all AP are associated with weight gain. The rational of switching AP to achieve weight reduction may be overrated. In AP-naive patients, weight gain is more pronounced. PMID:24763306

Almost all antipsychotics result in weight gain: a meta-analysis.

PubMed

Bak, Maarten; Fransen, Annemarie; Janssen, Jouke; van Os, Jim; Drukker, Marjan

2014-01-01

Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses generally are restricted to second generation antipsychotics (SGA) and do not stratify for duration of AP use. It is hypothesised that patients gain more weight if duration of AP use is longer. A meta-analysis was conducted of clinical trials of AP that reported weight change. Outcome measures were body weight change, change in BMI and clinically relevant weight change (7% weight gain or loss). Duration of AP-use was stratified as follows: ≤6 weeks, 6-16 weeks, 16-38 weeks and >38 weeks. Forest plots stratified by AP as well as by duration of use were generated and results were summarised in figures. 307 articles met inclusion criteria. The majority were AP switch studies. Almost all AP showed a degree of weight gain after prolonged use, except for amisulpride, aripiprazole and ziprasidone, for which prolonged exposure resulted in negligible weight change. The level of weight gain per AP varied from discrete to severe. Contrary to expectations, switch of AP did not result in weight loss for amisulpride, aripiprazole or ziprasidone. In AP-naive patients, weight gain was much more pronounced for all AP. Given prolonged exposure, virtually all AP are associated with weight gain. The rational of switching AP to achieve weight reduction may be overrated. In AP-naive patients, weight gain is more pronounced.

Robert Burk Gives Inaugural Wacholder Lecture on HPV and cervical cancer research

Cancer.gov

In April 2018, DCEG welcomed Robert Burk, M.D., as the inaugural Sholom Wacholder Distinguished Lecturer in Quantitative Health Sciences. The lectureship is named in memory of Dr. Sholom Wacholder, who worked at the intersection of quantitative reasoning and science.

Evaluation Report III: The Robert Noyce Scholarship Program at CSUB

ERIC Educational Resources Information Center

Wang, Jianjun

2013-01-01

California State University, Bakersfield (CSUB) received funding from National Science Foundation's (NSF) Robert Noyce Teacher Scholarship Program to recruit Noyce Scholars from upper-division science, technology, engineering, and mathematics (STEM) majors, graduate students, and professionals switched to STEM teaching from other fields (NSF…

Robert Weinberg: Scientist of the Year.

ERIC Educational Resources Information Center

Langone, John

1983-01-01

Highlights the background, career, and major accomplishments of Robert Allan Weinberg, professor of Biology at the Massachusetts Institute of Technology. His accomplishments and research interests focus on oncogenes, genes capable of causing cancer. The discovery of these genes has revealed the central mechanism of cancer. (Author/JN)

78 FR 62648 - Cat Island National Wildlife Refuge; West Feliciana Parish, Louisiana

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... comments, questions, and requests for information to: Robert Strader, Project Leader, USFWS, Lower... Paduani, Project Planner, 662-323-5548, [email protected] or Robert Strader, Project Leader, 601... conserve, enhance, and restore the historic native bottomland community characteristics of the lower...

The Legacy of Robert M. Gagne.

ERIC Educational Resources Information Center

Richey, Rita C., Ed.

This book highlights and discusses the contributions of Robert M. Gagne to the field of instructional technology. Section One presents the core concepts of Gagne's theory and contains reprints of the following five journal articles by Gagne: "Contributions of Learning to Human Development,""Learning Hierarchies,""Domains…

Official portrait of astronaut Robert D.Cabana

NASA Technical Reports Server (NTRS)

1985-01-01

Official portrait of astronaut Robert D.Cabana, a colonel in the United States Marine Corps (USMC) and a member of the 1985 Astronaut Class 11. Cabana is wearing a blue flight suit and poses with an American flag and asmall model of the space shuttle orbiter.

Robert Owen, William Maclure and New Harmony.

ERIC Educational Resources Information Center

Mclaren, David J.

1996-01-01

Discusses the utopian philosophy and related educational practices of the early 19th-century communitarian settlement in New Harmony, Indiana. The settlement failed after several years, due in no small part to the falling out between its two main supporters, Robert Owen and William Maclure. (MJP)

Robert Seymour Bridges om: Poet, physician and philosopher

PubMed Central

James, Theodore

1994-01-01

There has not been an English poet more interested in prosody nor physician more taken to medicine for its human contact, nor philosopher who lived closer to the tenets of his belief, than Robert Bridges (1844–1930). ImagesFigure 1.Figure 2. PMID:8207726

Rule of Law in Afghanistan -- Time for a New Approach?

DTIC Science & Technology

2009-03-17

accessed November 7 2008) 139 Gates, Robert M. Afghanistan Command Restructuring Worthy of Consideration. Texarkana , Texas, May 2, 2008 By Donna Miles...products/GAO-08-661 (accessed November 2 2008) Gates, Robert M. Afghanistan Command Restructuring Worthy of Consideration. Texarkana , Texas, May

1100398

NASA Image and Video Library

2011-03-24

CHARLES BOLDEN NASA ADMINISTRATOR TOURING AND SPEAKING AT THE US. SPACE AND ROCKET CENTER, HUNTSVILLE, ALABAMA. ACCOMPANYING ADMINISTRATOR BOLDEN ARE DR. DEBORAH BARNHART, CEO OF THE USSARC, ROBERT LIGHTFOOT, CENTER DIRECTOR OF MARSHALL SPACE FLIGHT CENTER AND RETIRED NASA ASTRONAUT ROBERT LEE “HOOT” GIBSON, ADMINISTRATOR BOLDEN’S FIRST SPACE FLIGHT COMMANDER.

78 FR 36557 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

76 FR 44031 - Arkansas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

78 FR 45549 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42... Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In Presidentially...

Robert Frost: Teacher "Earner, Learner, Yearner."

ERIC Educational Resources Information Center

Vogel, Nancy Sue

An account of Robert Frost's teaching, along with an assessment of it, are presented. Material consulted includes Frost's published letters, prose, and poetry; Lawrance Thompson's authorized biography; Lesley Frost's "New Hampshire's Child: The Derry Journals of Lesley Frost;" and additional sources such as films and periodicals,…

Underwater EVA training in the WETF with astronaut Robert L. Stewart

NASA Technical Reports Server (NTRS)

1983-01-01

Underwater extravehicular activity (EVA) training in the weightless environment training facility (WETF) with astronaut Robert L. Stewart. Stewart is simulating a planned EVA using the mobile foot restraint device and a one-G version of the Canadian-built remote manipulator system.

Identification of Major Enzymes Involved in the Synthesis of Diadenosine Tetraphosphate and/or Adenosine Tetraphosphate in Myxococcus xanthus.

PubMed

Kimura, Yoshio; Tanaka, Chihiro; Oka, Manami

2018-07-01

Myxococcus xanthus generates diadenosine tetraphosphates (Ap 4 A) and diadenosine pentaphosphates (Ap 5 A) under various stress conditions. M. xanthus lysyl-tRNA synthetase (LysS) efficiently synthesizes Ap 4 A from ATP, Ap 5 A from ATP and adenosine tetraphosphate (Ap 4 ), and Ap 4 from ATP and triphosphate. To identify other M. xanthus enzymes that can catalyze Ap 4 A and Ap 4 synthesis, 15 M. xanthus aminoacyl-tRNA synthetases (aaRSs), four acyl-CoA synthetases (Acys), three acetyl-CoA synthetases (Aces), phosphoglycerate kinase (Pgk), and adenylate kinase (Adk) were expressed in Escherichia coli and examined for Ap 4 A or Ap 4 synthetase activity using ATP or ATP and triphosphate as substrates. Among the tested enzymes, LysS had the highest Ap 4 A synthetase activity. AlaRS, SerRS, and LeuRS1 showed high ADP synthetase activity with ATP as a substrate in the presence of pyrophosphatase, and also demonstrated the ability to produce Ap 4 from ATP and triphosphate in the absence of pyrophosphatase. Ap 4 formation by AlaRS, SerRS, and LeuRS1 was approximately 4- to 13-fold higher compared with that of Ap 4 A, suggesting that these enzymes prefer triphosphate over ATP as a substrate in the second reaction. Some of the recombinant M. xanthus Acys and Aces also synthesized Ap 4 from ATP and triphosphate. However, Pgk was capable of catalyzing the production of Ap 4 from ATP and 3-phosphoglycerate in the presence of Mg 2+ and did not require triphosphate, suggesting that this enzyme is mainly responsible for Ap 4 synthesis in M. xanthus.

Revealing the Universe

NASA Astrophysics Data System (ADS)

Cornell, James; Lightman, Alan

1983-05-01

Contributors include Owen Gingerich, Kenneth Bracher, Robert F. C. Vessot, Fred L. Whipple, Fred Franklin, Robert W. Noyes, Robert Rosner, Harvey Tananbaum, Alan P. Lightman, Walter H. G. Lewin, William H. Press, John Huchra, and George B. Field. Alan Lightman, a Fellow of the American Academy of Arts & Sciences since 1996, is adjunct professor of humanities at MIT. He is the author of several books on science, including "Ancient Light: Our Changing View of the Universe" (1991) and "Origins: The Lives and Worlds of Modern Cosmologists" (with R. Brawer, 1990). His works of fiction include "Einstein's Dreams" (1993), "The Diagnosis" (2000), which was a finalist for the National Book Award, and, most recently, "Reunion" (2003).

The creativity of Crumb: research on the effects of psychedelic drugs on the comic art of Robert Crumb.

PubMed

Jones, Matthew T

2007-09-01

This article investigates the influence of perception that is altered by psychedelic drugs on processes of creativity through a case study of the work of well-known comic artist Robert Crumb. Samples of Crumb's work before, during, and after the period of his use of psychedelic drugs are content analyzed and compared according to the categorization offered by Janiger and Dobkin de Rios (1989). The results of the comparison indicate that Robert Crumb's drug use significantly altered the stylistic approach of his artwork not only during the period of his drug use, but long after he had stopped using drugs.

MicroRNAs to Pathways in Prostate Cancer Progression

DTIC Science & Technology

2015-12-01

PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Dr. Robert Blelloch and Dr. Cassandra Belair email: Robert.Blelloch@ucsf.edu 5e. TASK...Budget period of: 09/30/2013-09/29/2014: Name  Robert Blelloch  Project  Role  PI  Research Identifier Nearest person month  1.2  Contribution to... Project :  Dr. Blelloch was responsible for overall  coordination of this  project .  He was involved in  the design, interpretation and publication of all

Clinical significance of the summating potential-action potential ratio and the action potential latency difference for condensation and rarefaction clicks in Meniere's disease.

PubMed

Ohashi, Toru; Nishino, Hirohito; Arai, Yoko; Hyodo, Makoto; Takatsu, Mitsuharu

2009-04-01

This study was aimed to elucidate the diagnostic significance of the summating potential (SP)-action potential (AP) ratio and the AP latency difference between condensation and rarefaction clicks (AP con-rar difference) in Meniere's disease. The AP and SP were recorded transtympanically in 67 patients with definite Meniere's disease. The SP/AP ratio and the AP con-rar difference were assessed in terms of 1) their interrelationship, 2) their relationship to hearing level, and 3) the rate of occurrence of abnormal values according to the stages of Meniere's disease. No correlation was found between the SP/AP ratio and the AP con-rar difference. Neither the SP/AP ratio in general nor the AP con-rar difference was correlated with the hearing level. However, enhanced values of the SP/AP ratio (0.35 or higher) were moderately correlated with the hearing level (r = 0.51), and their occurrence rate was 55.2%. An increased AP con-rar difference (0.13 ms or longer) was not correlated with the hearing level, and its occurrence rate was 50.2%; it appeared most frequently at stage 3 (p <0.05). An enhanced SP/AP ratio might not always indicate the presence of endolymphatic hydrops associated with an increase in endolymphatic pressure. An increased AP con-rar difference might reflect the presence of a biased basilar membrane resulting from an increased endolymphatic pressure, and hence it is diagnostically essential to simultaneously evaluate the SP/AP ratio and the AP con-rar difference.

76 FR 36000 - Rulemaking Petition: Independent Expenditure Reporting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... sent to the Federal Election Commission, Attn.: Robert M. Knop, Assistant General Counsel, 999 E [[Page... CONTACT: Mr. Robert M. Knop, Assistant General Counsel, or Ms. Cheryl A. F. Hemsley, Attorney, 999 E... FEDERAL ELECTION COMMISSION 11 CFR Part 109 [Notice 2011-09] Rulemaking Petition: Independent...

16. VIEW OF ROBERT VOGEL, CURATOR, DIVISION OF MECHANICAL & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. VIEW OF ROBERT VOGEL, CURATOR, DIVISION OF MECHANICAL & CIVIL ENGINEER, NATIONAL MUSEUM OF AMERICAN HISTORY, SMITHSONIAN INSTITUTION, SITTING IN ELEVATOR CAR. MR. VOGEL IS RESPONSIBLE FOR THE RELOCATION OF THE ELEVATOR TO THE SMITHSONIAN INSTITUTION - 72 Marlborough Street, Residential Hydraulic Elevator, Boston, Suffolk County, MA

Supreme Court Roundup

ERIC Educational Resources Information Center

Williams, Charles F.

2005-01-01

Reactions to the retirement of Justice Sandra Day O'Connor and debate over the president's replacement nomination, Judge John Roberts, Jr., of the D.C. Circuit, dominated this summer's Supreme Court recess. Subsequently, after Chief Justice William H. Rehnquist's death on September 3, 2005, President Bush nominated Roberts for the chief justice…

Robert Frost, Teacher.

ERIC Educational Resources Information Center

Vogel, Nancy

This biography explores poet Robert Frost's techniques as a teacher from the early days of teaching at Pinkerton Academy in Derry, New Hampshire, to his acceptance of a chair at Harvard University and his subsequent associations with numerous other schools. Also examined are his educational practices and philosophy--particularly his life-long…

The Way Robert Sees It

ERIC Educational Resources Information Center

Freado, Mark D.; Wille, A. Katherine

2007-01-01

Robert, a fifteen-year-old resident in a residential treatment program, was diagnosed with significant hearing impairment. He communicates primarily through American Sign Language, although he speaks relatively well and has some hearing ability. Katie, a youth worker who has participated in Life Space Crisis Intervention (LSCI) training, worked…

76 FR 61757 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... become K-12 mathematics and science teachers. The program provides funds to institutions of higher... Foundation's (NSF) Robert Noyce Teacher Scholarship (Noyce) Program. Title of Collection: Evaluation of the Robert Noyce Teacher Scholarship Program. OMB Control No.: 3145-0217. Expiration Date of Approval: June...

ROBERT BOBO AND MIKE NICHOLS AT TEST STAND 4693

NASA Image and Video Library

2016-12-14

ROBERT BOBO, LEFT, AND MIKE NICHOLS TALK BENEATH THE 221-FOOT-TALL TEST STAND 4693, THE LARGEST OF TWO NEW SPACE LAUNCH SYSTEM TEST STANDS AT MSFC. BOBO MANAGES SLS STRUCTURAL STRENGTH TESTING, AND NICHOLS IS LEAD TEST ENGINEER FOR THE SLS LIQUID HYDROGEN TANK.

Suspended Substrate Resonator Design

DTIC Science & Technology

1990-12-01

1967. 10. Fred E. Gardiol, "Careful MIC Design Prevents Waveguide Modes", Microwaves, pp. 188-191, May 1977. 11. David Rubin and Alfred R. Hislop ...34Design Techniques for Sus- pended Substrate and Microstrip", Microwave Journal, October 1980 . 12. Robert Grover Brown, Robert A. Sharpe, William E. Post

The Ayes Have It.

ERIC Educational Resources Information Center

Keating, Tom

1996-01-01

Without procedural rules, school boards could not do business. Board members consulted revealed that they agree with the rules in theory but often do not follow them in practice. Lists 10 parliamentary rules to remember. Includes a brief biography of Henry M. Robert, who originated "Robert's Rules of Order." (MLF)

Remediating Language Deficient/Dyslexic College Students: An Interview with Robert Nash.

ERIC Educational Resources Information Center

Lundquist, Arlene J.; Nash, Robert

1988-01-01

Robert Nash responds to questions concerning his personal and professional background, the Simultaneous Multisensory Instructional Procedure for Teaching the Complete Sound Structure of the Language, problems associated with dyslexia, the social/emotional impact of learning disabilities, and the University of Wisconsin's Project Success for…

Robert Lowth and the Strong Verb System.

ERIC Educational Resources Information Center

van Ostade, Ingrid Tieken-Boon

2002-01-01

Traces the origin of the grammatical rule that strong verbs should distinguish between past tense and past participle forms. The rule, credited to Robert Lowth, did not in fact originate from Lowth nor did it reflect his usage as found in his private unpublished letters. (Author/VWL)

Publications - GMC 233 | Alaska Division of Geological & Geophysical

Science.gov Websites

Tidal Datum Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Geologic Hazards in geologic field program in Lower Cook Inlet, Alaska Authors: Roberts, Chuck, Coastal Science Laboratories publication sales page for more information. Bibliographic Reference Roberts, Chuck, Coastal Science

Stylistic Analysis of Robert Browning's Poem "Patriot into Traitor

ERIC Educational Resources Information Center

Ahmed, Mumtaz; Irshad, Ayesha

2015-01-01

The stylistic analysis of Robert Browning's poem "Patriot into Traitor" is done by using graphological, phonological, morphological and lexico-syntactic patterns. This analysis is helpful in decoding the underlying meanings of the poem. It clearly brings to surface what the poet really wants to impart.

NASA Acting Administrator Robert Lightfoot All Hands

NASA Image and Video Library

2017-08-15

At NASA's Kennedy Space Center in Florida, agency Acting Administrator Robert Lightfoot speaks to employees during a town hall meeting in the conference room of Operations Support Building II. To the right is Deputy Associate Administrator Lesa Roe. During the gathering, they updated progress on NASA programs.

Transformer Specification Language: A System for Generating Analyzers and Its Applications

DTIC Science & Technology

2011-01-01

like to thank present and former colleagues in PL group, Evan Driscoll, Aditya Thakur, Matt Elder, Tushar Sharma , Prathmesh Prabhu, Tycho Andersen, Emma...Robert Cohn, Robert Muth, Harish Patil, Artur Klauser, Geoff Lowney, Steven Wallace, Vijay Janapa Reddi, and Kim Hazelwood. Pin: building customized

Using "The Contender" by Robert Lipsyte.

ERIC Educational Resources Information Center

Christenbury, Leila

The novels of Robert Lipsyte are excellent for use in a middle school or secondary school classroom. His 1967 classic, "The Contender," and its sequel, "The Brave," are both strong on characterization, plot, and theme. Focusing on "The Contender," students can explore contending characters, forces, and themes. Related…

Robert Wilson's Invitation to Insanity.

ERIC Educational Resources Information Center

Stephens, Judith L.

The plays of stage director Robert Wilson are devices presenting alternative modes of perception to theatre audiences accustomed to verbal/aural structures of experience. Uniting his interests in the arts and therapy, his plays create a theatrical event promoting empathy with the perceptions of the mentally or physically handicapped and…

United States Navy Oceanic Armed Reconnaissance System

DTIC Science & Technology

2011-12-12

This report was prepared by: Rahul Petrie Daniel Reese Kurtis Hoots Robert Taylor Drew Nash Bunny Cooper Jonathan Trdan-Schmidt Marshall...NPS – Cohort 311-102S, Team OARS: Mr. Marshall Rice, Mr. Rahul Petrie, Mr. Daniel Reese, Mr. Kurtis Hoots, Mr. Robert Taylor, Mr. Drew Nash

75 FR 11112 - Action Affecting Export Privileges; Robert Kraaipoel

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Robert.... Take any action that facilitates the acquisition or attempted acquisition by the Denied Person of the... any action to acquire from or to facilitate the acquisition or attempted acquisition from the Denied...

Discovering Moral Engagement: An Interview with Robert Coles.

ERIC Educational Resources Information Center

Scott, Bradwell D.

1995-01-01

Educator Robert Coles argues that there is a need for a basis on which to teach and cultivate moral awareness in parents and children. Active parenting requires both inner-directed and outer-directed focuses to take advantage of the everyday events through which morality is developed. (SLD)

76 FR 33775 - Tennessee; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-09

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

76 FR 34090 - Missouri; Major Disaster and Related Determinations

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2011-06-10

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

78 FR 36556 - Oklahoma; Major Disaster and Related Determinations

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2013-06-18

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 41942 - Alaska; Major Disaster and Related Determinations

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2013-07-12

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C...; 97.048, Disaster Housing Assistance to Individuals and Households In Presidentially Declared Disaster...

78 FR 45547 - North Dakota; Major Disaster and Related Determinations

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2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 32414 - Illinois; Major Disaster and Related Determinations

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2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency..., Disaster Housing Assistance to Individuals and Households In Presidentially Declared Disaster Areas; 97.049...

77 FR 20043 - Indiana; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

75 FR 30419 - Kentucky; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

Robert Frost and the American College.

ERIC Educational Resources Information Center

Newdick, Robert S.

1999-01-01

The life and works of poet Robert Frost are examined for insights into his philosophy concerning higher education, particularly formal education, his own style of teaching, perceptions of the teacher's role within and outside the classroom, and the relationship between student and teacher. (Originally published in 1936) (MSE)

Influence of N-alkylation on organ distribution of radioiodinated amphetamines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Machulla, H.J.; Schmidt, U.; Mehdorn, H.M.

1985-05-01

In spite of numerous animal data and the widespread clinical application of p-(I-123)-N-isopropyl-amphetamine, questions remain open about the role of N-alkylation. Therefore, amphetamine (AP), N-methyl- (MeAP), and N-isopropyl-amphetamine (IsAP) were radioiodinated in the para position and the organ distribution was determined in male mice (Freiburg tribe) 10 weeks of age. In the lungs, all derivatives showed principally the same kinetics. In brain, the maximum uptake was reached after 30 min with 12%/g for AP and MeAP, and 10.5%/g for IsAP. In liver, the radioactivity similarly increased during the first 15 min to approx. 12%/g; afterwards, AP clearly decreased but MeAPmore » remained almost constant up to 120 min and, even more, IsAP increased to a maximum of 18%/g at 30 min. The same brain uptake kinetics for all 3 substances exclude the importance of lipophilicity increased by the N-alkylation. Furthermore, the differences in the liver kinetics of AP and both MeAP and IsAP indicate the importance of liver metabolism on the alkylated amphetamines. The results support the hypothesis that the first important metabolite of the N-alkylated derivatives is the amphetamine which accumulates in the brain as do MeAP and IsAP. On the basis of these findings, AP was applied clinically showing the same efficient brain uptake and distribution in SPECT as IsAP.« less

Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats.

PubMed

Sun, Deqing; Xue, Aiying; Zhang, Bin; Lou, Haiyan; Shi, Huanying; Zhang, Xiumei

2015-12-01

Acetylpuerarin (AP) is an acetylated derivative of puerarin (PUE). The study aimed to prepare polysorbate 80-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles to improve the permeability of AP across the blood-brain barrier (BBB) and enhance its brain-protective effects. AP-loaded PLGA nanoparticles (AP-PLGA-NPs) were prepared using a solvent diffusion methodology. The NPs were characterized. The pharmacokinetics, tissue distributions and brain-protective effects of AP-PLGA-NPs were evaluated in animals. AP-PLGA-NPs were successfully prepared with a mean particle size of 145.0 nm and a zeta potential of -14.81 mV. The in-vitro release of AP from the PLGA-NPs showed a biphasic release profile. AP was metabolized into PUE in rats. The AUC0-∞ values of AP and PUE for AP-PLGA-NPs were 2.90- and 2.29-fold as great as those for AP solution, respectively. The values of the relative targeting efficiency in the brain were 2.40 and 2.58 for AP and PUE, and the ratios of peak concentration were 1.91 and 1.89 for AP and PUE, respectively. Compared with the crude drug, AP-PLGA-NPs showed better brain-protective effects in rats. Polysorbate 80-coated PLGA-NPs can improve the permeability of AP cross the BBB and enhance its brain-protective effects in rats. © 2015 Royal Pharmaceutical Society.

Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon.

PubMed

Wang, Hao-Ven; Vaupel, Kristina; Buettner, Reinhard; Bosserhoff, Anja-Katrin; Moser, Markus

2004-09-01

AP-2 proteins comprise a family of highly related transcription factors, which are expressed during mouse embryogenesis in a variety of ectodermal, neuroectodermal, and mesenchymal tissues. AP-2 transcription factors were shown to be involved in morphogenesis of craniofacial, urogenital, neural crest-derived, and placental tissues. By means of a partial cDNA fragment identified during an expressed sequence tag search for AP-2 genes, we identified a fifth, previously unknown AP-2-related gene, AP-2 epsilon. AP-2 epsilon encodes an open reading frame of 434 amino acids, which reveals the typical modular structure of AP-2 transcription factors with highly conserved C-terminal DNA binding and dimerization domains. Although the N-terminally localized activation domain is less homologous, position and identity of amino acids essential for transcriptional transactivation are conserved. Reverse transcriptase-polymerase chain reaction analyses of murine embryos revealed AP-2 epsilon expression from gestational stage embryonic day 7.5 throughout all later embryonic stages until birth. Whole-mount in situ hybridization using a specific AP-2 epsilon cDNA fragment demonstrated that during embryogenesis, expression of AP-2 epsilon is mainly restricted to neural tissue, especially the midbrain, hindbrain, and olfactory bulb. This expression pattern was confirmed by immunohistochemistry with an AP-2 epsilon-specific antiserum. By using this antiserum, we could further localize AP-2 epsilon expression in a hypothalamic nucleus and the neuroepithelium of the vomeronasal organ, suggesting an important function of AP-2 epsilon for the development of the olfactory system.

Ectopic expression of Jatropha curcas APETALA1 (JcAP1) caused early flowering in Arabidopsis, but not in Jatropha

PubMed Central

Tang, Mingyong; Tao, Yan-Bin

2016-01-01

Jatropha curcas is a promising feedstock for biofuel production because Jatropha oil is highly suitable for the production of biodiesel and bio-jet fuels. However, Jatropha exhibits a low seed yield as a result of unreliable and poor flowering. APETALA1 (AP1) is a floral meristem and organ identity gene in higher plants. The flower meristem identity genes of Jatropha have not yet been identified or characterized. To better understand the genetic control of flowering in Jatropha, an AP1 homolog (JcAP1) was isolated from Jatropha. An amino acid sequence analysis of JcAP1 revealed a high similarity to the AP1 proteins of other perennial plants. JcAP1 was expressed in inflorescence buds, flower buds, sepals and petals. The highest expression level was observed during the early developmental stage of the flower buds. The overexpression of JcAP1 using the cauliflower mosaic virus (CaMV) 35S promoter resulted in extremely early flowering and abnormal flowers in transgenic Arabidopsis plants. Several flowering genes downstream of AP1 were up-regulated in the JcAP1-overexpressing transgenic plant lines. Furthermore, JcAP1 overexpression rescued the phenotype caused by the Arabidopsis AP1 loss-of-function mutant ap1-11. Therefore, JcAP1 is an ortholog of AtAP1, which plays a similar role in the regulation of flowering in Arabidopsis. However, the overexpression of JcAP1 in Jatropha using the same promoter resulted in little variation in the flowering time and floral organs, indicating that JcAP1 may be insufficient to regulate flowering by itself in Jatropha. This study helps to elucidate the function of JcAP1 and contributes to the understanding of the molecular mechanisms of flower development in Jatropha. PMID:27168978

The duality of LysU, a catalyst for both Ap4A and Ap3A formation.

PubMed

Wright, Michael; Boonyalai, Nonlawat; Tanner, Julian A; Hindley, Alison D; Miller, Andrew D

2006-08-01

Heat shock inducible lysyl-tRNA synthetase of Escherichia coli (LysU) is known to be a highly efficient diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) synthase. However, we use an ion-exchange HPLC technique to demonstrate that active LysU mixtures actually have a dual catalytic activity, initially producing Ap4A from ATP, before converting that tetraphosphate to a triphosphate. LysU appears to be an effective diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) synthase. Mechanistic investigations reveal that Ap3A formation requires: (a) that the second step of Ap4A formation is slightly reversible, thereby leading to a modest reappearance of adenylate intermediate; and (b) that phosphate is present to trap the intermediate (either as inorganic phosphate, as added ADP, or as ADP generated in situ from inorganic phosphate). Ap3A forms readily from Ap4A in the presence of such phosphate-based adenylate traps (via a 'reverse-trap' mechanism). LysU is also clearly demonstrated to exist in a phosphorylated state that is more physically robust as a catalyst of Ap4A formation than the nonphosphorylated state. However, phosphorylated LysU shows only marginally improved catalytic efficiency. We note that Ap3A effects have barely been studied in prokaryotic organisms. By contrast, there is a body of literature that describes Ap3A and Ap4A having substantially different functions in eukaryotic cells. Our data suggest that Ap3A and Ap4A biosynthesis could be linked together through a single prokaryotic dual 'synthase' enzyme. Therefore, in our view there is a need for new research into the effects and impact of Ap3A alone and the intracellular [Ap3A]/[Ap4A] ratio on prokaryotic organisms.

Changes in extracellular pH and myocardial ischaemia alter the cardiac effects of diadenosine tetraphosphate and pentaphosphate

PubMed Central

Stavrou, Brigitte M; Beck, Caroline; Flores, Nicholas A

2001-01-01

The structural conformation of diadenosine tetraphosphate (Ap4A) and pentaphosphate (Ap5A) has been reported to alter as pH is reduced. As such, it is possible that the cardiac effects of Ap4A and Ap5A vary during acidosis and myocardial ischaemia due to changes in ligand structure, receptor proteins or intracellular signalling. We investigated whether the cardiac electrophysiological and coronary vasomotor effects of Ap4A and Ap5A are preserved under conditions of extracellular acidosis (pH 6.5) and alkalosis (pH 8.5) and whether Ap4A has any electrophysiological or antiarrhythmic effects during ischaemia. Transmembrane right ventricular action potentials, refractory periods and coronary perfusion pressure were recorded from isolated, Langendorff-perfused guinea-pig hearts under constant flow conditions. The effects of 1 nM and 1 μM Ap4A and Ap5A were studied at pH 7.4, 6.5 and 8.5. The effects of 1 μM Ap4A were studied during global low-flow ischaemia and reperfusion. At pH 7.4, Ap4A and Ap5A increased action potential duration (APD95) and refractory period (RP) and reduced coronary perfusion pressure. The electrophysiological effects were absent at pH 6.5 while the reductions in perfusion pressure were attenuated. At pH 8.5, Ap4A increased RP but the effects of Ap4A and Ap5A on perfusion pressure were attenuated. During ischaemia, Ap4A had no antiarrhythmic or electrophysiological effects. These data demonstrate the importance of extracellular pH in influencing the effects of Ap4A and Ap5A on the heart and indicate that any potentially cardioprotective effects of these compounds during normal perfusion at physiological pH are absent during ischaemia. PMID:11588119

Functional Identification and Characterization of the Brassica Napus Transcription Factor Gene BnAP2, the Ortholog of Arabidopsis Thaliana APETALA2

PubMed Central

Xiong, Zhiyong; Chen, Chunli; Wang, Lijun; Yu, Jingyin; Lu, Changming; Wei, Wenhui

2012-01-01

BnAP2, an APETALA2 (AP2)-like gene, has been isolated from Brassica napus cultivar Zhongshuang 9. The cDNA of BnAP2, with 1, 299 bp in length, encoded a transcription factor comprising of 432 amino acid residues. Results from complementary experiment indicated that BnAP2 was completely capable of restoring the phenotype of Arabidopsis ap2-11 mutant. Together with the sequence and expression data, the complementation data suggested that BnAP2 encodes the ortholog of AtAP2. To address the transcriptional activation of BnAP2, we performed transactivation assays in yeast. Fusion protein of BnAP2 with GAL4 DNA binding domain strongly activated transcription in yeast, and the transactivating activity of BnAP2 was localized to the N-terminal 100 amino acids. To further study the function of BnAP2 involved in the phenotype of B. napus, we used a transgenic approach that involved targeted RNA interference (RNAi) repression induced by ihp-RNA. Floral various phenotype defectives and reduced female fertility were observed in B. napus BnAP2-RNAi lines. Loss of the function of BnAP2 gene also resulted in delayed sepal abscission and senescence with the ethylene-independent pathway. In the strong BnAP2-RNAi lines, seeds showed defects in shape, structure and development and larger size. Strong BnAP2-RNAi and wild-type seeds initially did not display a significant difference in morphology at 10 DAF, but the development of BnAP2-RNAi seeds was slower than that of wild type at 20 DAF, and further at 30 DAF, wild-type seeds were essentially at their final size, whereas BnAP2-RNAi seeds stopped growing and developing and gradually withered. PMID:22479468

Functional identification and characterization of the Brassica napus transcription factor gene BnAP2, the ortholog of Arabidopsis thaliana APETALA2.

PubMed

Yan, Xiaohong; Zhang, Lei; Chen, Bo; Xiong, Zhiyong; Chen, Chunli; Wang, Lijun; Yu, Jingyin; Lu, Changming; Wei, Wenhui

2012-01-01

BnAP2, an APETALA2 (AP2)-like gene, has been isolated from Brassica napus cultivar Zhongshuang 9. The cDNA of BnAP2, with 1, 299 bp in length, encoded a transcription factor comprising of 432 amino acid residues. Results from complementary experiment indicated that BnAP2 was completely capable of restoring the phenotype of Arabidopsis ap2-11 mutant. Together with the sequence and expression data, the complementation data suggested that BnAP2 encodes the ortholog of AtAP2. To address the transcriptional activation of BnAP2, we performed transactivation assays in yeast. Fusion protein of BnAP2 with GAL4 DNA binding domain strongly activated transcription in yeast, and the transactivating activity of BnAP2 was localized to the N-terminal 100 amino acids. To further study the function of BnAP2 involved in the phenotype of B. napus, we used a transgenic approach that involved targeted RNA interference (RNAi) repression induced by ihp-RNA. Floral various phenotype defectives and reduced female fertility were observed in B. napus BnAP2-RNAi lines. Loss of the function of BnAP2 gene also resulted in delayed sepal abscission and senescence with the ethylene-independent pathway. In the strong BnAP2-RNAi lines, seeds showed defects in shape, structure and development and larger size. Strong BnAP2-RNAi and wild-type seeds initially did not display a significant difference in morphology at 10 DAF, but the development of BnAP2-RNAi seeds was slower than that of wild type at 20 DAF, and further at 30 DAF, wild-type seeds were essentially at their final size, whereas BnAP2-RNAi seeds stopped growing and developing and gradually withered.

Activation of the Arabidopsis B class homeotic genes by APETALA1.

PubMed

Ng, M; Yanofsky, M F

2001-04-01

Proper development of petals and stamens in Arabidopsis flowers requires the activities of APETALA3 (AP3) and PISTILLATA (PI), whose transcripts can be detected in the petal and stamen primordia. Localized expression of AP3 and PI requires the activities of at least three genes: APETALA1 (AP1), LEAFY (LFY), and UNUSUAL FLORAL ORGANS (UFO). It has been proposed that UFO provides spatial cues and that LFY specifies competence for AP3 and PI expression in the developing flower. To understand the epistatic relationship among AP1, LFY, and UFO in regulating AP3 and PI expression, we generated two versions of AP1 that have strong transcriptional activation potential. Genetic and molecular analyses of transgenic plants expressing these activated AP1 proteins show that the endogenous AP1 protein acts largely as a transcriptional activator in vivo and that AP1 specifies petals by regulating the spatial domains of AP3 and PI expression through UFO.

Anodal sensory nerve action potentials: From physiological understanding to potential clinical applicability.

PubMed

Leote, Joao; Pereira, Pedro; Cabib, Christopher; Cipullo, Federica; Valls-Sole, Josep

2016-06-01

Low-intensity electrical stimuli of digital nerves may generate a double peak potential (DPp), composed of a cathodal (caAP) and an anodal (anAP) potential in orthodromic recordings. We studied the effects on caAP and anAP of stimuli of variable intensity, duration, and frequency. We also applied a conditioning stimulus to study potential differences in recovery time. The anAP was obtained in 33 of 40 healthy subjects (82.5%) and 4 of 20 patients with various types of sensory neuropathies (20%). Changes in stimulus duration and intensity had reciprocal effects on the amplitude of the anAP and the caAP. There were significant differences in recovery time between caAP and anAP after a conditioning stimulus. The caAP and anAP are 2 interdependent waveforms generated by different effects of the same stimulus over axons at the verge of depolarization. Muscle Nerve 53: 897-905, 2016. © 2015 Wiley Periodicals, Inc.

Gender, Academics and Interscholastic Sports Participation at the School Level: A Gender-specific Analysis of the Relationship between Interscholastic Sports Participation and AP Enrollment

PubMed Central

Veliz, Philip; Shakib, Sohaila

2014-01-01

While literature demonstrates that interscholastic sports participation is associated with positive academic outcomes, this relationship is rarely analyzed at a macro-level (the school-level). To date, there is no research examining whether increases in schools’ female and male interscholastic sports participation rates is associated with increases in female and male AP enrollment rates. Using a national sample of 4,644 public high schools during the 2009-2010 school year, we test several gender-specific hypotheses linked with the association between schools’ sport participation rates and advanced placement enrollment rates (AP math, AP science, AP foreign language, and overall AP enrollment). The findings reveal that schools’ female and male sports participation rates have a positive association with schools’ female and male AP math, AP science, AP foreign language, and overall AP enrollment rates. Moreover, the findings suggest that females benefit more than males in regard to the positive relationship between interscholastic sports and AP enrollment. PMID:24910475

Functions of Adaptor Protein (AP)-3 and AP-1 in Tyrosinase Sorting from Endosomes to MelanosomesD⃞

PubMed Central

Theos, Alexander C.; Tenza, Danièle; Martina, José A.; Hurbain, Ilse; Peden, Andrew A.; Sviderskaya, Elena V.; Stewart, Abigail; Robinson, Margaret S.; Bennett, Dorothy C.; Cutler, Daniel F.; Bonifacino, Juan S.; Marks, Michael S.; Raposo, Graça

2005-01-01

Specialized cells exploit adaptor protein complexes for unique post-Golgi sorting events, providing a unique model system to specify adaptor function. Here, we show that AP-3 and AP-1 function independently in sorting of the melanocyte-specific protein tyrosinase from endosomes to the melanosome, a specialized lysosome-related organelle distinguishable from lysosomes. AP-3 and AP-1 localize in melanocytes primarily to clathrin-coated buds on tubular early endosomes near melanosomes. Both adaptors recognize the tyrosinase dileucine-based melanosome sorting signal, and tyrosinase largely colocalizes with each adaptor on endosomes. In AP-3-deficient melanocytes, tyrosinase accumulates inappropriately in vacuolar and multivesicular endosomes. Nevertheless, a substantial fraction still accumulates on melanosomes, concomitant with increased association with endosomal AP-1. Our data indicate that AP-3 and AP-1 function in partially redundant pathways to transfer tyrosinase from distinct endosomal subdomains to melanosomes and that the AP-3 pathway ensures that tyrosinase averts entrapment on internal membranes of forming multivesicular bodies. PMID:16162817

Advances in Bacterial Methionine Aminopeptidase Inhibition

PubMed Central

Helgren, Travis R.; Wangtrakuldee, Phumvadee; Staker, Bart L.; Hagen, Timothy J.

2016-01-01

Methionine aminopeptidases (MetAPs) are metalloenzymes that cleave the N-terminal methionine from newly synthesized peptides and proteins. These MetAP enzymes are present in bacteria, and knockout experiments have shown that MetAP activity is essential for cell life, suggesting that MetAPs are good antibacterial drug targets. MetAP enzymes are also present in the human host and selectivity is essential. There have been significant structural biology efforts and over 65 protein crystal structures of bacterial MetAPs are deposited into the PDB. This review highlights the available crystallographic data for bacterial MetAPs. Structural comparison of bacterial MetAPs with human MetAPs highlights differences that can lead to selectivity. In addition, this review includes the chemical diversity of molecules that bind and inhibit the bacterial MetAP enzymes. Analysis of the structural biology and chemical space of known bacterial MetAP inhibitors leads to a greater understanding of this antibacterial target and the likely development of potential antibacterial agents. PMID:26268344

Characterization and subcellular localization of aminopeptidases in senescing barley leaves

NASA Technical Reports Server (NTRS)

Thayer, S. S.; Choe, H. T.; Rausser, S.; Huffaker, R. C.

1988-01-01

Four aminopeptidases (APs) were separated using native polyacrylamide gel electrophoresis of cell-free extracts and the stromal fractions of isolated chloroplasts prepared from primary barley (Hordeum vulgare L., var Numar) leaves. Activities were identified using a series of aminoacyl-beta-naphthylamide derivatives as substrates. AP1, 2, and 3 were found in the stromal fraction of isolated chloroplasts with respective molecular masses of 66.7, 56.5, and 54.6 kilodaltons. AP4 was found only in the cytoplasmic fraction. No AP activity was found in vacuoles of these leaves. It was found that 50% of the L-Leu-beta-naphthylamide and 25% of the L-Arg-beta-naphthylamide activities were localized in the chloroplasts. Several AP activities were associated with the membranes of the thylakoid fraction of isolated chloroplasts. AP1, 2, and 4 reacted against a broad range of substrates, whereas AP3 hydrolyzed only L-Arg-beta-naphthylamide. Only AP2 hydrolyzed L-Val-beta-naphthylamide. Since AP2 and AP3 were the only ones reacting against Val-beta-naphthylamide and Arg-beta-naphthylamide, respectively, several protease inhibitors were tested against these substrates using a stromal fraction from isolated chloroplasts as the source of the two APs. Both APs were sensitive to both metallo and sulfhydryl type inhibitors. Although AP activity decreased as leaves senesced, no new APs appeared on gels during senescence and none disappeared.

Next-generation transcriptome analysis in transgenic birch overexpressing and suppressing APETALA1 sheds lights in reproduction development and diterpenoid biosynthesis.

PubMed

Huang, Haijiao; Chen, Su; Li, Huiyu; Jiang, Jing

2015-09-01

Overexpression of BpAP1 could cause early flowering in birch. BpAP1 affected the expression of many flowering-related unigenes and diterpenoid biosynthesis in transgenic birch, and BpPI was a putative target gene of BpAP1. APETALA1 (AP1) is an MADS-box transcription factor that is involved in the flowering process in plants and has been a focus of genetic studies examining flower development. Here, we carried out transcriptome analysis of birch (Betula platyphylla Suk.), including BpAP1 overexpression lines, BpAP1 suppression lines, and non-transgenic line (NT). Compared with NT, we detected 8302 and 7813 differentially expressed unigenes in 35S::BpAP1 and 35S::BpAP1RNAi transgenic lines, respectively. Overexpression and suppression of BpAP1 in birch affected diterpenoid biosynthesis and altered expression of many flowering-related unigenes. Moreover, combining information from the RNA-seq database and the birch genome, we predicted downstream target genes of BpAP1. Among the 166 putative target genes of BpAP1, there was a positive correlation between BpAP1 and BpPI. These results provide references for further examining the relationship between BpAP1 and its target genes, and reveal that BpAP1 functions as a transcription regulator in birch.

A dwarf galaxy's transformation and a massive galaxy's edge: detailed modeling of the extended stream in NGC1097

NASA Astrophysics Data System (ADS)

Cristiano Amorisco, Nicola; Martinez-Delgado, David

2015-08-01

Low surface brightness tidal features around massive galaxies are the smoking gun of hierarchical galaxy formation. These debris are informative of: (i) the evolutionary struggles of the progenitor dwarf galaxies, transformed and partially destroyed by the tides; (ii) the formation history of the massive host, its halo populations and the structure of its dark matter halo. However, extracting reliable measurements of the progenitor’s initial mass, infall time, host halo mass and density profile has so far been difficult, as the parameter space is too wide to explore with N-body simulations.We use new deep imaging data of the extended, X shaped stream in NGC1097 [1,2] and a new dynamical technique to quantitatively reconstruct: (i) the density profile of the massive spiral host (inferred virial mass M200=1012.25±0.1 M⊙) ; and (ii) the dramatic evolution of the progenitor galaxy; by modeling its stream within a fully statistical framework. I will show that the current location of the remnant coincides with a nucleated dwarf Spheroidal, with a luminosity of ~3.3x106LV,⊙ [3], and a predicted total mass of M(<0.45±0.2 kpc)=107.8±0.6 M⊙. This is the result of a strong transformation: at its first interaction with the host, 4.4±0.4 Gyr and three pericentric passages ago, the progenitor was over two orders of magnitude more massive, with Mtot(3.2±0.7 kpc)=1010.4±0.2 M⊙. Its orbit has a pericenter of a few kpc, but reaches out to 150±12 kpc. In this range the stream’s morphology allows us to see the total density slope of the host bending and steepening towards large radii. For the first time in a single galaxy (rather than on stacked data), both central and outer slope are constrained by observations and can be compared to LCDM expectations [4]. Finally, I will discuss prospects of applying this technique to more known streams, to map the structure of a wider sample of galaxy haloes and unveil the evolutionary histories of more individual dwarf galaxies.Refs.[1] Arp, 1976, ApJ, 207[2] Higdon & Wallin, 2003, ApJ, 585[3] Galianni et al., 2010, A&A, 521[4] Diemer & Kravtsov, 2014, ApJ, 789

Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.

PubMed

Laloi, Maryse; McCarthy, James; Morandi, Olivia; Gysler, Christof; Bucheli, Peter

2002-09-01

Aspartic proteinase (EC 3.4.23) activity plays a pivotal role in the degradation of Theobroma cacao L. seed proteins during the fermentation step of cacao bean processing. Therefore, this enzyme is believed to be critical for the formation of the peptide and amino acid cocoa flavor precursors that occurs during fermentation. Using cDNA cloning and northern blot analysis, we show here that there are at least two distinct aspartic proteinase genes ( TcAP1 and TcAP2) expressed during cacao seed development. Both genes are expressed early during seed development and their mRNA levels decrease towards the end of seed maturation. TcAP2 is expressed at a much higher level than TcAP1, although the expression of TcAP1 increases slightly during germination. The proteins encoded by TcAP1 and TcAP2 are relatively different from each other (73% identity). This, and the fact that the two corresponding genes have different expression patterns, suggests that the TcAP1 and TcAP2 proteins may have different functions in the maturing seeds and during germination. Because the TcAP2 gene is expressed at a much higher level during seed development than TcAP1, it is likely that the TcAP2 protein is primarily responsible for the majority of the industrially important protein hydrolysis that occurs during cacao bean fermentation. Finally, TcAP2 has been functionally expressed in the yeast Yarrowia lipolytica. The secreted recombinant protein is able to hydrolyse bovine haemoglobin at acidic pH and is sensitive to pepstatin A, confirming that TcAP2 encodes an aspartic proteinase, and strongly suggests that this gene encodes the well-characterized aspartic proteinase of mature cacao seeds.

Airpower and Gradual Escalation: Reconsidering the Conventional Wisdom

DTIC Science & Technology

2000-06-01

Argument Without End : In Search of Answers to the Vietnam Tragedy (New...1979); Robert S. McNamara, et al. Argument Without End : In Search of Answers to the Vietnam Tragedy (New York: PublicAffairs, 1999); McNamara with...Robert S., et al. Argument Without End : In Search of

78 FR 27996 - Notice of Intent To Repatriate Cultural Items: The Robert S. Peabody Museum of Archaeology...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-13

..., Phillips Academy, Andover, MA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Robert S. Peabody Museum of Archaeology, Phillips Academy, Andover, MA, in consultation with the..., Phillips Academy, Andover, MA 01810, telephone (978) 749-4490. SUPPLEMENTARY INFORMATION: Notice is here...

3. Historic American Buildings Survey Robert J. Kelley, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey Robert J. Kelley, Photographer May 1958 NORTH ELEVATION BUILT BY OLIVER PHELPS c. 1793 AND PROBABLY DESIGNED BY ASHER BENJAMIN (WHO ALSO MADE CHANGES ON MAIN HOUSE TO MAKE IT CONFORM WITH NEW ELEVATION) - Burbank-Hatheway House, Main Street, Suffield, Hartford County, CT

75 FR 22175 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-27

..., James Layfield, Dana O. Lundgren, Raymond Meza, Robert L. Moore, Charles Noll, George H. Southland..., Robert Key, Christopher D. Linden, Patrick W. Merkel, Gene M. Morris, James L. Putnam, Jr., Donald W.... Glaser, George Klopf, Luke R. Lafley, Brian K. La Joie, John L. Langill, Gregg A. Lindberg, John R...

Lydia J. Roberts's Nutrition Research and the Rhetoric of "Democratic" Science

ERIC Educational Resources Information Center

Jack, Jordynn

2009-01-01

This article examines nutritionist Lydia J. Roberts's use of the "democratic approach" as a rhetorical strategy both to build solidarity among scientists and to enact participatory research in a rural Puerto Rican community. This example suggests that participatory scientific methodologies are not necessarily democratic but may function…

75 FR 47062 - Advisory Committee on Disability Compensation; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

... Committee's review to Mr. Robert Watkins, Department of Veterans Affairs, Veterans Benefits Administration... meeting or seeking additional information should contact Mr. Watkins at (202) 461- 9214 or e-mail at Robert.Watkins@va.gov . Dated: July 29, 2010. By Direction of the Secretary. Vivian Drake, Acting...

75 FR 42773 - Notice of Inventory Completion: Robert S. Peabody Museum of Archaeology, Phillips Academy...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... Museum of Archaeology, Phillips Academy, Andover, MA AGENCY: National Park Service, Interior. ACTION... control of the Robert S. Peabody Museum of Archaeology, Phillips Academy, Andover, MA. The associated.... 3003(d)(3). The determinations in this notice are the sole responsibility of the museum, institution...

Of Postulates and Peccadillos: Robert Koch and Vaccine (Tuberculin) Therapy for Tuberculosis

DTIC Science & Technology

1993-01-01

E The Founders of Modern Medicine Walden 5 Koch. P, Weitere Mittheilungen uber emn Heftmittel gegen Publications. New York. 1939. p 73 Tuberculose ...uber emn Heilnitel gegen 45 Brock, T D Robert Koch. A Life in Medicine and Bacteriology ’ Tuberculose [Continuation of the announcement concerning a

"Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacob, Robert

Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

John Dewey and Robert Pirsig: An Invitation to "Fresh Seeing."

ERIC Educational Resources Information Center

Granger, David A.

While reading John Dewey's "Art as Experience" and Robert Pirsig's "Zen and the Art of Motorcycle Maintenance: An Inquiry into Values," a graduate student observed close affinities between what Dewey referred to as "experience" and Pirsig referred to as "quality." Both texts are concerned with cultivating…

The Roberts Court and Academic Freedom

ERIC Educational Resources Information Center

Rahdert, Mark C.

2007-01-01

Since President Bush named Chief Justice John G. Roberts Jr. and Justice Samuel A. Alito Jr. to the Supreme Court, speculation has run high as to where the new court may be headed. Citing three recent cases ("Morse v. Frederick", "Rumsfeld v. Forum for Academic and Institutional Rights, Inc." and "Garcetti v.…

The College Teaching of English.

ERIC Educational Resources Information Center

Gerber, John C., Ed.

Thirteen essays on the teaching of college English are included--(1) "Prospect" by John H. Fisher, (2) "The Study and Teaching of English" by William C. De Vane, (3) "Introductory Literature Courses" by Hoyt Trowbridge, (4) "General and Interdisciplinary Courses" by Robert C. Pooley, (5) "Freshman Composition" by Robert M. Gorrell, (6) "Advanced…

DefenseLink Feature: Travels with Gates

Science.gov Websites

Robert M. Gates said. Story Gates Connects NATO Afghanistan Effort With Terror Threat in Europe MUNICH , Germany, Feb. 10, 2008 - The war on terror in Afghanistan is Europe's war, too, Defense Secretary Robert M ministers during meetings in Vilnius, Lithuania. Story Pakistan Understands Terror Danger VILNIUS, Lithuania

Adaptive Explicitly Parallel Instruction Computing

DTIC Science & Technology

2000-12-16

New York, NY, 1984. ACM. [33] Robert P. Colwell, Robert P. Nix, John J. O’Donnell, David P. Papworth, and Paul K. Rodman . A VLIW architecture for a...C. Ebeling, editors, Research on Integrated Systems: Proceedings of the 1993 Symposium, pages 183–199, 1993. [50] J. Gailly and M. Adler . ZLIB

4. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1944 ('Fig. 4-D') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

3. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1874 ('Fig. 4-C') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

2. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1866 ('Fig 4-B') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

Defense.gov - Special Report

Science.gov Websites

FORUM - U.S. Defense Secretary Robert M. Gates addresses the audience as Canadian Minister of National issues that Defense Secretary Robert M. Gates and Canadian Defense Minister Peter MacKay discussed during a bilateral meeting here today. Story | Transcript U.S., Canadian Defense Chiefs Answer Afghanistan

Who Was Robert Lawson?

ERIC Educational Resources Information Center

Hearn, Michael Patrick

1997-01-01

Recounts the life and career of Robert Lawson, an author and illustrator who is neglected today but who was responsible for three very popular children's books in the 1930s and 1940s. States that he is still the only person ever to receive both the Caldecott Award and the Newbery Medal. (PA)

Plan Aggregation for Strong Cyclic Planning in Nondeterministic Domains

DTIC Science & Technology

2014-07-02

Plan Aggregation for Strong Cyclic Planning in Nondeterministic Domains Ron Alforda, Ugur Kuterc, Dana Naub, Robert P. Goldmanc aASEE/NRL...addresses: ronald.alford.ctr@nrl.navy.mil (Ron Alford), ukuter@sift.net ( Ugur Kuter), nau@cs.umd.edu (Dana Nau), rpgoldman@sift.net (Robert P. Goldman

[Book review] A field guide to western reptiles and amphibians (Second Edition, Revised), by Robert C. Stebbins and Roger Tory Peterson

USGS Publications Warehouse

Jennings, M.R.

1987-01-01

Review of: A Field Guide to Western Reptiles and Amphibians (Peterson Field Guides, No. 16). Robert C. Stebbins and Roger Tory Peterson. Houghton Mifflin; 2nd Revised edition (June 10, 1985). 448 pages. ISBN: 978-0395382530.

28. Historic American Buildings Survey Robert M. Vogel, Photographer October, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. Historic American Buildings Survey Robert M. Vogel, Photographer October, 1970 PHOTOCOPY OF AN 1877 VIEW OF THE CROWN AND EAGLE MILLS, AS SEEN FROM THE SOUTH From the collection of the Stanley Woolen Company, Uxbridge, Massachusetts - Crown & Eagle Mills, 123 Hartford Avenue East, North Uxbridge, Worcester County, MA

Democracy "Is" Working

ERIC Educational Resources Information Center

Owen-Smith, Jason; Scott, Christopher Thomas; McCormick, Jennifer B.

2012-01-01

As contemporary students of science and science policy, these authors find it hard to gainsay the easy abstractions of Hurlbut and Robert's commentary. "Good science is an achievement of a good society." They also share much common ground on the details. For instance, they endorse the majority of Hurlbut and Robert's thoughts with regard to the…

We Are Our Mothers' Daughters?

ERIC Educational Resources Information Center

Grady, Marilyn L.; LaCost, Barbara Y.

2004-01-01

Writing that makes one think, writing that enriches one's understanding of the past and present, that's what Cokie Roberts' book, "We Are Our Mothers' Daughters" provides, and that, too, is what the authors of this issue of the "Journal of Women in Educational Leadership" provide. Roberts' background as a news analyst covering politics, Congress…

Impact of a Robert Noyce Scholarship on STEM Teacher Recruitment

ERIC Educational Resources Information Center

Morrell, Patricia D.; Salomone, Stephanie

2017-01-01

Funding from the Robert Noyce Teacher Scholarship Program supports the University of Portland Noyce Scholars and Interns Program (University of Portland Noyce Program). This study examined the first 3 years of the University of Portland Noyce Program to determine its effectiveness in attracting science, technology, engineering, and mathematics…

Hours of Boredom, Moments of Terror: Temporal Desynchrony in Military and Security Force Operations

DTIC Science & Technology

2010-10-01

Administrative Science Quarterly 24 (1979), 285–306. 31 Robert A. Karasek and Tores Theorell , Healthy Work: Stress, Productivity and the...first symptoms of incipient failure. 30 Robert A. Karasek , “Job Demands, Job Decision Latitude and Mental Strain: Implications for Job Redesign

Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California

EPA Science Inventory

Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California Mark G. Cantwell, David R. Katz, Julia Sullivan, Robert P. Eganhouse, Monique M. Perron, Robert M. Burgess The Palos Verdes shelf is located off the Southern California coa...

Robert Henry Thurston: Professionalism and Engineering Education

ERIC Educational Resources Information Center

Nienkamp, Paul

2016-01-01

Robert Henry Thurston is presented in this article. He provides one the most significant examples of professionalizing engineering through innovative education and promoting scientific education practices in the late nineteenth century. The son of a draftsmen and steam engine mechanic, Thurston spent his early years in Providence, Rhode Island.…

Suicide Prevention: The Student Assistance Model.

ERIC Educational Resources Information Center

Taylor-Mearhoff, Cheryl

The Roberts Assistance Program (RAP), a model program for student assistance and suicide prevention established in 1988 by the Owen J. Roberts School District in Chester County, Pennsylvania provides services to students in kindergarten through grade 12. Core teams of school professionals from the high school and middle school have received…

Robert Green's "James IV:" Love, Power, and Justice.

ERIC Educational Resources Information Center

Hayashi, Tetsumaro

1984-01-01

How events of the late medieval period of Great Britain are depicted in Robert Greene's play, "The Scottish History of James the Fourth," is discussed. The play reflects the spirit of a time in which some began to claim that women were the intellectual equals of men. (RM)

A Corps of Naval Strategists.

DTIC Science & Technology

1983-06-01

p. 284. 6 4 Igor H. Ansoff , Roger P. Declerck and Robert L. Hayes, From Strategic Management, (New York: John Wiley and Sons, 1976) p. 39-40. 65 III...U.S. Government Printing Office, 1983. Ansoff , Igor H., Declerck, Roger P. and Hayes, Robert L., From Strategic Management, New York: John Wiley and

Using Performance as an Interpretive Strategy in Teaching Robert Browning's "My Last Duchess."

ERIC Educational Resources Information Center

Schevera, Nicholas

1997-01-01

Uses role-playing, dramatic monologues, and "tableaux vivant" to interpret Robert Browning's poem "My Last Duchess" in an introductory literature class at Westchester Community College. Notes that performative strategies illustrate connections in the poem that often remain unnoticed on a first reading. (PA)

1. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, 1856 ('Fig. 4-A') - M. R. Tidrick House, 122 South Fourth Avenue, Winterset, Madison County, IA

"Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

ScienceCinema

Jacob, Robert

2018-02-07

Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

Role of Reconnaissance in the Counterattack.

DTIC Science & Technology

2016-05-26

Bejing: Foreign Language Press, 1967), 107. Sun - Tzu , The Art of Warfare, translated by Robert Ames (New York: Ballantine Books, 1993), 113. 14 B.H...dhat: qissat hayati. Cairo, Egypt: al-Maktab al-Misri al-Hadith, 1985. Sun - Tzu . The Art of Warfare. Translated by Robert Ames. New York: Ballantine...39 Bibliography

The Decline of Air Assault Operations

DTIC Science & Technology

2016-05-26

Anthology (Carlisle Barracks: US Army War College, 2000), 6-7. 94 Clausewitz, 198; Sun Tzu , The Art of Warfare, trans. Robert Ames (New York...Encyclopedia of World War II. Santa Barbara: ABC-CLIO, 2004. Tzu , Sun . The Art of Warfare. Trans. Robert Ames. New York: Ballentine Books, 1993. 55... Bibliography ...................................................................................................................................51 iv

78 FR 51203 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

76 FR 32984 - Arkansas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

77 FR 69648 - Rhode Island; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 23278 - Rhode Island; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-18

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households in...

78 FR 45548 - Montana; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. Sec. Sec... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households in...

78 FR 32415 - South Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 38728 - Michigan; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 36557 - North Dakota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In...

76 FR 61375 - Vermont; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

... declared a major disaster under the authority of the Robert T. Stafford Disaster Relief and Emergency... the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households in...

78 FR 51204 - Colorado; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

78 FR 38727 - Vermont; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In...

78 FR 32415 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and Households In...

76 FR 61729 - Massachusetts; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... severity and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

76 FR 72964 - Virginia; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief and..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

78 FR 32416 - Minnesota; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

76 FR 60515 - Connecticut; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford Act''), as follows: I have declared a major disaster under the Robert T. Stafford Disaster Relief and... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

75 FR 30419 - Mississippi; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... major disaster declaration under the authority of the Robert T. Stafford Disaster Relief and Emergency... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

76 FR 44031 - Vermont; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq..., Disaster Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing...

75 FR 65500 - North Carolina; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

... authority of the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... severity and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief... Grant; 97.048, Disaster Housing Assistance to Individuals and Households In Presidentially Declared...

77 FR 44648 - Florida; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... President issued a major disaster declaration under the authority of the Robert T. Stafford Disaster Relief... disaster declaration under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

Lesson Plans on African History and Geography: A Teaching Resource.

ERIC Educational Resources Information Center

Hamilton, Robert E., Ed.

This document presents lesson plans for instruction concerning the history and geography of the continent of Africa. Topics include: (1) "The Challenge of Teaching African History and Culture" (Robert Hamilton); (2) "A Physical Overview of Africa" (Robert Hamilton and Kim Lilly); (3) "A Cultural Overview of Africa"…

Conceptualising Childhood: Robert Louis Stevenson's "A Child's Garden of Verses."

ERIC Educational Resources Information Center

Webb, Jean

2002-01-01

Discusses the construct of childhood in Robert Louis Stevenson's collection of poems, "A Child's Garden of Verses," by employing notions of child development drawn from Jean Piaget and Lev Vygotsky. Finds, from a literary perspective, Stevenson's collection located on the boundaries of romanticism and modernism. (BT)

The Federal Public Works Infrastructure Strategy Program - Federal Works Infrastructure R&D: A New Perspective

DTIC Science & Technology

1993-07-01

Strategy, please contact Robert A. Pietrowsky , Program Manager at: Institute for Water Resources Casey Building 7701 Telegraph Road Fort Belvoir, VA 22060...management responsibility under the direction of Dr. Eugene Z. Stakhiv, Chief, Policy and Special Studies Division and Mr. Robert A. Pietrowsky , Program

Prevention of Breast Cell Transformation by Blockade of the AP-1 Transcription Factor

DTIC Science & Technology

2000-10-01

Distribution Unlimited 13. ABSTRACT (Maximum 200 Words) In this study, we are investigating the role of AP- M in controlling breast cell growth and...serum and these growth factors depend on AP-1 to transduce proliferative signal. AP- M blockade induced by the expression of TAM67 inhibits breast...demonstrated that TAM67 inhibits basal AP-1 activity and AP- M activity stimulated by several different growth factors. We have also discovered that AP-1

77 FR 19229 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

...; Joint Shrimp and Deepwater Shrimp AP; Dolphin Wahoo AP; King and Spanish Mackerel AP; and Coral AP in... Recreational Information Program and discuss allocation issues. 5. King and Spanish Mackerel AP Meeting: April 24-25, 2012 Members of the King and Spanish Mackerel AP will meet from 1:30 p.m. on April 24, 2012...

An exploration of the experiences of recent graduates from an interprofessional foundation degree.

PubMed

Norrie, Caroline; Hasselder, Alison; Manning, Chris

2012-11-01

This short report describes a study which aimed to explore the experiences of newly qualified assistant practitioners (APs) from an interprofessional foundation degree in long-term conditions. Interviews were carried out with one cohort of newly qualified APs and their employee mentors, 6-9 months after the APs had re-entered full-time practice. Three major themes were identified after analysis of the interview transcripts: widened AP horizons, poor AP pay and conditions and friction between APs and their colleagues. The course was highly praised by the APs and their workplace mentors. Unfortunately, the workplace infrastructure needed to support the APs was reported to be inadequate.

Comparative Ballistic Performance of 20mm AP M95 and 20mm AP M75 Projectiles against Rolled Homogeneous Steel Armor

DTIC Science & Technology

1960-05-01

Dominic A. Piccione, " Comparative Ballistic Performanceof 20mm AP M95 and 20mm AP M75 Projectiles againstRolled Homogeneous Steel Armor (U)’\\ WAL-TR-160.1/1... COMPARATIVE BALLISTIC PERFORMANCE OF 20MM AP M95 AND 20MM AP M75 PROJECTILES AGAINST ROLLED HOMOGENEOUS STEEL ARMOR (U) TECHNICAL REPORT NO. WAL TR I60.l/I(c...o > -< Abt9sortf bl O *_, o o -o WATERTOWN ARSENAL LABORATORIES co COMPARATIVE BALLISTIC PERFORMANCE OF 20MM AP M95 AND 20MM AP M75

Systematic review of hypertriglyceridemia-induced acute pancreatitis: A more virulent etiology?

PubMed

Carr, Rosalie A; Rejowski, Benjamin J; Cote, Gregory A; Pitt, Henry A; Zyromski, Nicholas J

2016-01-01

We sought to define the severity and natural history of hypertriglyceridemia induced acute pancreatitis (HTG-AP), specifically whether HTG-AP causes more severe AP than that caused by other etiologies. Systematic review of the English literature. Thirty-four studies (15 countries; 1972-2015) included 1340 HTG-AP patients (weighted mean prevalence of 9%). The median admission triglyceride concentration was 2622 mg/dl (range 1160-9769). Patients with HTG have a 14% weighted mean prevalence of AP. Plasmapheresis decreased circulating triglycerides, but did not conclusively affect AP mortality. Only 7 reports (n = 392 patients) compared severity of HTG-AP to that of AP from other etiologies. Of these, 2 studies found no difference in severity, while 5 suggested that HTG-AP patients may have increased severity compared to AP of other etiology. 1) hypertriglyceridemia is a relatively uncommon (9%) cause of acute pancreatitis; however, patients with hypertriglyceridemia have a high (14%) incidence of acute pancreatitis; 2) plasmapheresis may offer specific therapy unique to this patient population; and 3) data specifically comparing the severity of HTG-AP with AP caused by other etiologies are heterogeneous and scarce. Copyright © 2016. Published by Elsevier B.V.

Evaluation of dose‐area product of common radiographic examinations towards establishing a preliminary diagnostic reference levels (PDRLs) in Southwestern Nigeria

PubMed Central

Jibiri, Nnamdi N.

2016-01-01

In Nigeria, a large number of radiographic examinations are conducted yearly for various diagnostic purposes. However, most examinations carried out do not have records of doses received by the patients, and the employed exposure parameters used are not documented; therefore, adequate radiation dose management is hindered. The aim of the present study was to estimate the dose‐area product (DAP) of patients examined in Nigeria, and to propose regional reference dose levels for nine common examinations (chest PA, abdomen AP, pelvis AP, lumbar AP, skull AP, leg AP, knee AP, hand AP, and thigh AP) undertaken in Nigeria. Measurement of entrance surface dose (ESD) was carried out using thermoluminescent dosimeter (TLD). Measured ESDS were converted into DAP using the beam area of patients in 12 purposely selected hospitals. Results of the study show that the maximum/minimum ratio ranged from 3 for thigh AP to 57 in abdomen AP. The range of determined mean and 75th percentile DAPs were 0.18–17.16, and 0.25–28.59 Gy cm2, respectively. Data available for comparison show that 75th percentile DAPs in this study (in chest PA, abdomen AP, pelvis AP, lumbar AP) are higher than NRPB‐HPE reference values. The DAP in this study is higher by factor of 31.4 (chest PA), 9.9 (abdomen AP), 2.2 (pelvis AP), and 2.1 (lumbar AP) than NRPB‐HPE values. The relative higher dose found in this study shows nonoptimization of practice in Nigeria. It is expected that regular dose auditing and dose optimization implementation in Nigeria would lead to lower DAP value, especially in abdomen AP. The 75th percentile DAP distribution reported in this study could be taken as regional diagnostic reference level in the Southwestern Nigeria; however, a more extensive nationwide dose survey is required to establish national reference dose. PACS number(s): 87.53.Bn, 87.59.B PMID:27929511

Identifying risk factors for progression to critical care admission and death among individuals with acute pancreatitis: a record linkage analysis of Scottish healthcare databases

PubMed Central

Mole, Damian J; Gungabissoon, Usha; Johnston, Philip; Cochrane, Lynda; Hopkins, Leanne; Wyper, Grant M A; Skouras, Christos; Dibben, Chris; Sullivan, Frank; Morris, Andrew; Ward, Hester J T; Lawton, Andrew M; Donnan, Peter T

2016-01-01

Objectives Acute pancreatitis (AP) can initiate systemic complications that require support in critical care (CC). Our objective was to use the unified national health record to define the epidemiology of AP in Scotland, with a specific focus on deterministic and prognostic factors for CC admission in AP. Setting Health boards in Scotland (n=4). Participants We included all individuals in a retrospective observational cohort with at least one episode of AP (ICD10 code K85) occurring in Scotland from 1 April 2009 to 31 March 2012. 3340 individuals were coded as AP. Methods Data from 16 sources, spanning general practice, community prescribing, Accident and Emergency attendances, hospital in-patient, CC and mortality registries, were linked by a unique patient identifier in a national safe haven. Logistic regression and gamma models were used to define independent predictive factors for severe AP (sAP) requiring CC admission or leading to death. Results 2053 individuals (61.5% (95% CI 59.8% to 63.2%)) met the definition for true AP (tAP). 368 patients (17.9% of tAP (95% CI 16.2% to 19.6%)) were admitted to CC. Predictors of sAP were pre-existing angina or hypertension, hypocalcaemia and age 30–39 years, if type 2 diabetes mellitus was present. The risk of sAP was lower in patients with multiple previous episodes of AP. In-hospital mortality in tAP was 5.0% (95% CI 4.1% to 5.9%) overall and 21.7% (95% CI 19.9% to 23.5%) in those with tAP necessitating CC admission. Conclusions National record-linkage analysis of routinely collected data constitutes a powerful resource to model CC admission and prognosticate death during AP. Mortality in patients with AP who require CC admission remains high. PMID:27311912

Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity.

PubMed

Li, Jing-Ya; Cui, Yong-Mei; Chen, Ling-Ling; Gu, Min; Li, Jia; Nan, Fa-Jun; Ye, Qi-Zhuang

2004-05-14

Methionine aminopeptidase (MetAP) catalyzes the removal of methionine from newly synthesized polypeptides. MetAP carries out this cleavage with high precision, and Met is the only natural amino acid residue at the N terminus that is accepted, although type I and type II MetAPs use two different sets of residues to form the hydrophobic S1 site. Characteristics of the S1 binding pocket in type I MetAP were investigated by systematic mutation of each of the seven S1 residues in Escherichia coli MetAP type I (EcMetAP1) and human MetAP type I (HsMetAP1). We found that Tyr-65 and Trp-221 in EcMetAP1, as well as the corresponding residues Phe-197 and Trp-352 in HsMetAP1, were essential for the hydrolysis of a thiopeptolide substrate, Met-S-Gly-Phe. Mutation of Phe-191 to Ala in HsMetAP1 caused inactivity in contrast to the full activity of EcMetAP1(Y62A), which may suggest a subtle difference between the two type I enzymes. The more striking finding is that mutation of Cys-70 in EcMetAP1 or Cys-202 in HsMetAP1 opens up the S1 pocket. The thiopeptolides Leu-S-Gly-Phe and Phe-S-Gly-Phe, with previously unacceptable Leu or Phe as the N-terminal residue, became efficient substrates of EcMetAP1(C70A) and HsMetAP1(C202A). The relaxed specificity shown in these S1 site mutants for the N-terminal residues was confirmed by hydrolysis of peptide substrates and inhibition by reaction products. The structural features at the enzyme active site will be useful information for designing specific MetAP inhibitors for therapeutic applications.

Evaluation of dose-area product of common radiographic examinations towards establishing a preliminary diagnostic reference levels (PDRLs) in Southwestern Nigeria.

PubMed

Jibiri, Nnamdi N; Olowookere, Christopher J

2016-11-08

In Nigeria, a large number of radiographic examinations are conducted yearly for various diagnostic purposes. However, most examinations carried out do not have records of doses received by the patients, and the employed exposure parameters used are not documented; therefore, adequate radiation dose management is hin-dered. The aim of the present study was to estimate the dose-area product (DAP) of patients examined in Nigeria, and to propose regional reference dose levels for nine common examinations (chest PA, abdomen AP, pelvis AP, lumbar AP, skull AP, leg AP, knee AP, hand AP, and thigh AP) undertaken in Nigeria. Measurement of entrance surface dose (ESD) was carried out using thermoluminescent dosimeter (TLD). Measured ESDS were converted into DAP using the beam area of patients in 12 purposely selected hospitals. Results of the study show that the maximum/ minimum ratio ranged from 3 for thigh AP to 57 in abdomen AP. The range of determined mean and 75th percentile DAPs were 0.18-17.16, and 0.25-28.59 Gy cm2, respectively. Data available for comparison show that 75th percentile DAPs in this study (in chest PA, abdomen AP, pelvis AP, lumbar AP) are higher than NRPB-HPE reference values. The DAP in this study is higher by factor of 31.4 (chest PA), 9.9 (abdomen AP), 2.2 (pelvis AP), and 2.1 (lumbar AP) than NRPB-HPE values. The relative higher dose found in this study shows nonoptimization of practice in Nigeria. It is expected that regular dose auditing and dose optimization implementation in Nigeria would lead to lower DAP value, especially in abdomen AP. The 75th percentile DAP distribution reported in this study could be taken as regional diagnostic reference level in the Southwestern Nigeria; however, a more extensive nationwide dose survey is required to establish national reference dose. © 2016 The Authors.

Adaptation effects in static postural control by providing simultaneous visual feedback of center of pressure and center of gravity.

PubMed

Takeda, Kenta; Mani, Hiroki; Hasegawa, Naoya; Sato, Yuki; Tanaka, Shintaro; Maejima, Hiroshi; Asaka, Tadayoshi

2017-07-19

The benefit of visual feedback of the center of pressure (COP) on quiet standing is still debatable. This study aimed to investigate the adaptation effects of visual feedback training using both the COP and center of gravity (COG) during quiet standing. Thirty-four healthy young adults were divided into three groups randomly (COP + COG, COP, and control groups). A force plate was used to calculate the coordinates of the COP in the anteroposterior (COP AP ) and mediolateral (COP ML ) directions. A motion analysis system was used to calculate the coordinates of the center of mass (COM) in both directions (COM AP and COM ML ). The coordinates of the COG in the AP direction (COG AP ) were obtained from the force plate signals. Augmented visual feedback was presented on a screen in the form of fluctuation circles in the vertical direction that moved upward as the COP AP and/or COG AP moved forward and vice versa. The COP + COG group received the real-time COP AP and COG AP feedback simultaneously, whereas the COP group received the real-time COP AP feedback only. The control group received no visual feedback. In the training session, the COP + COG group was required to maintain an even distance between the COP AP and COG AP and reduce the COG AP fluctuation, whereas the COP group was required to reduce the COP AP fluctuation while standing on a foam pad. In test sessions, participants were instructed to keep their standing posture as quiet as possible on the foam pad before (pre-session) and after (post-session) the training sessions. In the post-session, the velocity and root mean square of COM AP in the COP + COG group were lower than those in the control group. In addition, the absolute value of the sum of the COP - COM distances in the COP + COG group was lower than that in the COP group. Furthermore, positive correlations were found between the COM AP velocity and COP - COM parameters. The results suggest that the novel visual feedback training that incorporates the COP AP -COG AP interaction reduces postural sway better than the training using the COP AP alone during quiet standing. That is, even COP AP fluctuation around the COG AP would be effective in reducing the COM AP velocity.

Structural characterization of the N-terminal mineral modification domains from the molluscan crystal-modulating biomineralization proteins, AP7 and AP24.

PubMed

Wustman, Brandon A; Morse, Daniel E; Evans, John Spencer

2004-08-05

The AP7 and AP24 proteins represent a class of mineral-interaction polypeptides that are found in the aragonite-containing nacre layer of mollusk shell (H. rufescens). These proteins have been shown to preferentially interfere with calcium carbonate mineral growth in vitro. It is believed that both proteins play an important role in aragonite polymorph selection in the mollusk shell. Previously, we demonstrated the 1-30 amino acid (AA) N-terminal sequences of AP7 and AP24 represent mineral interaction/modification domains in both proteins, as evidenced by their ability to frustrate calcium carbonate crystal growth at step edge regions. In this present report, using free N-terminal, C(alpha)-amide "capped" synthetic polypeptides representing the 1-30 AA regions of AP7 (AP7-1 polypeptide) and AP24 (AP24-1 polypeptide) and NMR spectroscopy, we confirm that both N-terminal sequences possess putative Ca (II) interaction polyanionic sequence regions (2 x -DD- in AP7-1, -DDDED- in AP24-1) that are random coil-like in structure. However, with regard to the remaining sequences regions, each polypeptide features unique structural differences. AP7-1 possesses an extended beta-strand or polyproline type II-like structure within the A11-M10, S12-V13, and S28-I27 sequence regions, with the remaining sequence regions adopting a random-coil-like structure, a trait common to other polyelectrolyte mineral-associated polypeptide sequences. Conversely, AP24-1 possesses random coil-like structure within A1-S9 and Q14-N16 sequence regions, and evidence for turn-like, bend, or loop conformation within the G10-N13, Q17-N24, and M29-F30 sequence regions, similar to the structures identified within the putative elastomeric proteins Lustrin A and sea urchin spicule matrix proteins. The similarities and differences in AP7 and AP24 N-terminal domain structure are discussed with regard to joint AP7-AP24 protein modification of calcium carbonate growth. Copyright 2004 Wiley Periodicals, Inc.

Robert Waelder and the application of psychoanalytic principles to social and political phenomena.

PubMed

Guttman, S A

1986-01-01

This presentation reveals a little-known area of Robert Waelder's work. As his literary executor, I have been privileged with access to his unpublished material, notes, and correspondence. And, of course, I am familiar with his mode of thinking. I wish to pass on some of this knowledge. What cannot be passed on, however, in some abstract intellectual way, are psychoanalytic principles themselves. Therefore, while this paper sheds light on a very particular aspect of Robert Waelder's work, it is also in some ways a cautionary tale, a plea that the reader understand what is behind the psychoanalytic point of view and its basic concepts--namely, clinical experience.

The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications.

PubMed

Mohandas, Namitha; Young, Neil D; Jabbar, Abdul; Korhonen, Pasi K; Koehler, Anson V; Hall, Ross S; Hu, Min; Hofmann, Andreas; Gasser, Robin B

2016-01-01

Although substantial research has been focused on the 'hidden antigen' H11 of Haemonchus contortus as a vaccine against haemonchosis in small ruminants, little is know about this and related aminopeptidases. In the present article, we reviewed genomic and transcriptomic data sets to define, for the first time, the complement of aminopeptidases (designated Hc-AP-1 to Hc-AP-13) of the family M1 with homologues in Caenorhabditis elegans, characterised by zinc-binding (HEXXH) and exo-peptidase (GAMEN) motifs. The three previously published H11 isoforms (accession nos. X94187, FJ481146 and AJ249941) had most sequence similarity to Hc-AP-2 and Hc-AP-8, whereas unpublished isoforms (accession nos. AJ249942 and AJ311316) were both most similar to Hc-AP-3. The aminopeptidases characterised here had homologues in C. elegans. Hc-AP-1 to Hc-AP-8 were most similar in amino acid sequence (28-41%) to C. elegans T07F10.1; Hc-AP-9 and Hc-AP-10 to C. elegans PAM-1 (isoform b) (53-54% similar); Hc-AP-11 and Hc-AP-12 to C. elegans AC3.5 and Y67D8C.9 (26% and 50% similar, respectively); and Hc-AP-13 to C. elegans C42C1.11 and ZC416.6 (50-58% similar). Comparative analysis suggested that Hc-AP-1 to Hc-AP-8 play roles in digestion, metabolite excretion, neuropeptide processing and/or osmotic regulation, with Hc-AP-4 and Hc-AP-7 having male-specific functional roles. The analysis also indicated that Hc-AP-9 and Hc-AP-10 might be involved in the degradation of cyclin (B3) and required to complete meiosis. Hc-AP-11 represents a leucyl/cystinyl aminopeptidase, predicted to have metallopeptidase and zinc ion binding activity, whereas Hc-AP-12 likely encodes an aminopeptidase Q homologue also with these activities and a possible role in gonad function. Finally, Hc-AP-13 is predicted to encode an aminopeptidase AP-1 homologue of C. elegans with hydrolase activity, suggested to operate, possibly synergistically with a PEPT-1 ortholog, as an oligopeptide transporter in the gut for protein uptake and normal development and/or reproduction of the worm. An appraisal of structure-based amino acid sequence alignments revealed that all conceptually translated Hc-AP proteins, with the exception of Hc-AP-12, adopt a topology similar to those observed for the two subgroups of mammalian M1 aminopeptidases, which possess either three (I, II and IV) or four (I-IV) domains. In contrast, Hc-AP-12 lacks the N-terminal domain (I), but possesses a substantially expanded domain III. Although further work needs to be done to assess amino acid sequence conservation of the different aminopeptidases among individual worms within and among H. contortus populations, we hope that these insights will support future localisation, structural and functional studies of these molecules in H. contortus as well as facilitate future assessments of a recombinant subunit or cocktail vaccine against haemonchosis. Copyright © 2015 Elsevier Inc. All rights reserved.

Theoretical studies on the electronic and optoelectronic properties of [A.2AP(w)/A*.2AP(WC)/C.2AP(w)/C*.2AP(WC)/C.A(w)/C*.A(WC)]-Au8 mismatch nucleobase complexes

NASA Astrophysics Data System (ADS)

Srivastava, Ruby

2018-01-01

The electronic and optoelectronic properties of [A.2AP(w)/A*.2AP(WC)/C.2AP(w)/C*.2AP(WC)/C.A(w)/ C*.A(WC)]-Au8 metal-mismatch nucleobase complexes are investigated by means of density functional theory and time-dependent methods. We selected these mispairs as 2-aminopurine (2AP) produces incorporation errors when binding with cytosine (C) into the wobble (w) C.2AP(w) mispair, and is tautomerised into Watson-Crick (WC)-like base mispair C*.2AP(WC) and less effectively produces A.2AP(w)/A*.2AP(WC) mispairs. The vertical ionisation potential, vertical electron affinity, hardness and electrophilicity index of these complexes have also been discussed. The modifications of energy levels and charge density distributions of the frontier orbitals are also analysed. The absorption spectra of these complexes lie in the visible region, which suggests their application in fluorescent-bio imaging. The mechanism of cooperativity effect is studied by molecular orbital potential (MEP), atoms-in-molecules (AIM) and natural bond orbital analyses. Most metalated pairs have smaller HOMO-LUMO band gaps than the isolated mismatch nucleobases which suggest interesting consequences for electron transfer through DNA duplexes.

New method for estimating clustering of DNA lesions induced by physical/chemical mutagens using fluorescence anisotropy.

PubMed

Akamatsu, Ken; Shikazono, Naoya; Saito, Takeshi

2017-11-01

We have developed a new method for estimating the localization of DNA damage such as apurinic/apyrimidinic sites (APs) on DNA using fluorescence anisotropy. This method is aimed at characterizing clustered DNA damage produced by DNA-damaging agents such as ionizing radiation and genotoxic chemicals. A fluorescent probe with an aminooxy group (AlexaFluor488) was used to label APs. We prepared a pUC19 plasmid with APs by heating under acidic conditions as a model for damaged DNA, and subsequently labeled the APs. We found that the observed fluorescence anisotropy (r obs ) decreases as averaged AP density (λ AP : number of APs per base pair) increases due to homo-FRET, and that the APs were randomly distributed. We applied this method to three DNA-damaging agents, 60 Co γ-rays, methyl methanesulfonate (MMS), and neocarzinostatin (NCS). We found that r obs -λ AP relationships differed significantly between MMS and NCS. At low AP density (λ AP  < 0.001), the APs induced by MMS seemed to not be closely distributed, whereas those induced by NCS were remarkably clustered. In contrast, the AP clustering induced by 60 Co γ-rays was similar to, but potentially more likely to occur than, random distribution. This simple method can be used to estimate mutagenicity of ionizing radiation and genotoxic chemicals. Copyright © 2017 Elsevier Inc. All rights reserved.

Developments in Assisting Countries in Implementing the IAEA Additional Protocol

DOE Office of Scientific and Technical Information (OSTI.GOV)

Killinger, Mark H.; Hansen, Linda H.; Cain, Ronald A.

In 2008, the U.S. Department of Energy (DOE) began assisting selected non-nuclear weapon states in planning and preparing for implementation of the International Atomic Energy Agency’s Additional Protocol (AP). Since then, the AP international implementation program has contributed to the substantial progress made by Vietnam, Thailand, Iraq, and Malaysia in preparing for entry-into-force of the AP. An overall engagement plan has been developed with components designed to train government AP implementing agencies, inform policy makers, conduct outreach to industry and universities, make AP reporting software available and useful, and plan a detailed approach for implementing the declaration and complementary accessmore » provisions of the AP. DOE recently began collaborating with Indonesia, which has already entered the AP into force, requiring a second method of engagement somewhat different from that taken with countries that have not entered the AP into force. The AP international implementation program, administered by the International Nuclear Safeguards and Engagement Program, is working more closely with DOE’s International Nonproliferation Export Control Program to ensure countries are aware of and prepared to implement the export/import provisions of the AP. As the AP implementation program matures and helps move countries closer to entry-into-force or improved AP implementation, it is identifying characteristics of a country’s “end-state” that indicate that DOE assistance is no longer required. The U.S. AP Implementation Act and Senate Resolution of Ratification require the Administration to report annually to Congress on measures taken to achieve the adoption of the AP in non-nuclear weapon states. DOE’s AP international implementation program is a significant part of these measures. This paper describes recent developments to increase the scope and effectiveness of the program.« less

Human Papillomavirus Type 16 E6 Induces Self-Ubiquitination of the E6AP Ubiquitin-Protein Ligase

PubMed Central

Kao, Wynn H.; Beaudenon, Sylvie L.; Talis, Andrea L.; Huibregtse, Jon M.; Howley, Peter M.

2000-01-01

The E6 protein of the high-risk human papillomaviruses (HPVs) and the cellular ubiquitin-protein ligase E6AP form a complex which causes the ubiquitination and degradation of p53. We show here that HPV16 E6 promotes the ubiquitination and degradation of E6AP itself. The half-life of E6AP is shorter in HPV-positive cervical cancer cells than in HPV-negative cervical cancer cells, and E6AP is stabilized in HPV-positive cancer cells when expression of the viral oncoproteins is repressed. Expression of HPV16 E6 in cells results in a threefold decrease in the half-life of transfected E6AP. E6-mediated degradation of E6AP requires (i) the binding of E6 to E6AP, (ii) the catalytic activity of E6AP, and (iii) activity of the 26S proteasome, suggesting that E6-E6AP interaction results in E6AP self-ubiquitination and degradation. In addition, both in vitro and in vivo experiments indicate that E6AP self-ubiquitination results primarily from an intramolecular transfer of ubiquitin from the active-site cysteine to one or more lysine residues; however, intermolecular transfer can also occur in the context of an E6-mediated E6AP multimer. Finally, we demonstrate that an E6 mutant that is able to immortalize human mammary epithelial cells but is unable to degrade p53 retains its ability to bind and degrade E6AP, raising the possibility that E6-mediated degradation of E6AP contributes to its ability to transform mammalian cells. PMID:10864652

Glaucoma patients present increased levels of diadenosine tetraphosphate, Ap(4)A, in the aqueous humour.

PubMed

Castany, Marta; Jordi, Isabel; Catala, Jaume; Gual, Arcadi; Morales, Miguel; Gasull, Xavier; Pintor, Jesus

2011-03-01

Previous studies have shown the presence of diadenosine tetraphosphate (Ap(4)A) and pentaphosphate (Ap(5)A) in the aqueous humour (AH) of different species. When topically applied to the rabbit cornea, Ap(4)A decreased IOP while Ap(5)A increased it. Here we study the presence of dinucleoside polyphosphates in the AH from human patients with or without glaucoma. AH was obtained at the time of cataract surgery from patients with (n=16) or without (n=10) primary open-angle glaucoma. AH (0.1-0.2 ml) was collected at the beginning of surgery through a corneal paracentesis and immediately cooled in liquid nitrogen, kept frozen and protected from light. AH aliquots were analyzed by HPLC for the presence of Ap(4)A and Ap(5)A. Both, Ap(4)A and Ap(5)A were detected in the AH of both experimental groups. No significant differences were found for Ap(5)A. In contrast, Ap(4)A levels were increased by ∼15-fold in the AH from glaucomatous eyes ranging from 19.5±9.2 nM in normal individuals to 286.03±30.9 nM in glaucomatous patients. In conclusion, both Ap(4)A and Ap(5)A were detected for the first time in human AH. Interestingly, glaucomatous eyes presented elevated concentrations of Ap(4)A compared to controls. The role of Ap(4)A needs to be elucidated but it may help to protect the autonomic innervation in the ciliary body/trabecular meshwork. Also, because of its higher levels in glaucoma patients it may be considered as a possible glaucoma biomarker. Copyright © 2010 Elsevier Ltd. All rights reserved.

APETALA2 like genes from Picea abies show functional similarities to their Arabidopsis homologues.

PubMed

Nilsson, Lars; Carlsbecker, Annelie; Sundås-Larsson, Annika; Vahala, Tiina

2007-02-01

In angiosperm flower development the identity of the floral organs is determined by the A, B and C factors. Here we present the characterisation of three homologues of the A class gene APETALA2 (AP2) from the conifer Picea abies (Norway spruce), Picea abies APETALA2 LIKE1 (PaAP2L1), PaAP2L2 and PaAP2L3. Similar to AP2 these genes contain sequence motifs complementary to miRNA172 that has been shown to regulate AP2 in Arabidopsis. The genes display distinct expression patterns during plant development; in the female-cone bud PaAP2L1 and PaAP2L3 are expressed in the seed-bearing ovuliferous scale in a pattern complementary to each other, and overlapping with the expression of the C class-related gene DAL2. To study the function of PaAP2L1 and PaAP2L2 the genes were expressed in Arabidopsis. The transgenic PaAP2L2 plants were stunted and flowered later than control plants. Flowers were indeterminate and produced an excess of floral organs most severely in the two inner whorls, associated with an ectopic expression of the meristem-regulating gene WUSCHEL. No homeotic changes in floral-organ identities occurred, but in the ap2-1 mutant background PaAP2L2 was able to promote petal identity, indicating that the spruce AP2 gene has the capacity to substitute for an A class gene in Arabidopsis. In spite of the long evolutionary distance between angiosperms and gymnosperms and the fact that gymnosperms lack structures homologous to sepals and petals our data supports a functional conservation of AP2 genes among the seed plants.

One animal among many: Veterinarians in the global community

PubMed Central

Waltner-Toews, David

1989-01-01

Evidence from chemistry, physics, the biological sciences and the earth sciences is now accumulating that the earth functions as a living organism, with all the implications of circulatory and homeostatic systems which that implies. As veterinarians, we are more than simply handmaidens to agribusiness, the academic, pet and food industries, or government regulatory agencies. While our jobs may be specific, dependent, and circumscribed, our vocation can be nothing less than the health-care of all animal life — and hence by direct implication, the care of the earth, as a living organism, itself. Imagesp13-ap14-ap15-ap16-ap17-ap18-ap19-ap20-ap20-b PMID:17423204

AP reclamation and reuse in RSRM propellant

NASA Technical Reports Server (NTRS)

Miks, Kathryn F.; Harris, Stacey A.

1995-01-01

A solid propellant ingredient reclamation pilot plant has been evaluated at the Strategic Operations of Thiokol Corporation, located in Brigham City, Utah. The plant produces AP wet cake (95 percent AP, 5 percent water) for recycling at AP vendors. AP has been obtained from two standard propellant binder systems (PBAN and HTPB). Analytical work conducted at Thiokol indicates that the vendor-recrystallized AP meets Space Shuttle propellant specification requirements. Thiokol has processed 1-, 5-, and 600-gallon propellant mixes with the recrystallized AP. Processing, cast, cure, ballistic, mechanical, and safety properties have been evaluated. Phillips Laboratory static-test-fired 70-pound and 800-pound BATES motors. The data indicate that propellant processed with reclaimed AP has nominal properties.

Evidence for effective structure-based neuromodulatory effects of new analogues of neurosteroid allopregnanolone.

PubMed

Taleb, O; Patte-Mensah, C; Meyer, L; Kemmel, V; Geoffroy, P; Miesch, M; Mensah-Nyagan, A-G

2018-02-01

The neurosteroid allopregnanolone (AP) modulates neuroendocrine/neurobiological processes, including hypothalamic-pituitary-adrenocortical activities, pain, anxiety, neurogenesis and neuroprotection. These observations raised the hope of developing AP-based therapies against neuroendocrine and/or neurodegenerative disorders. However, the pleiotropic actions of AP, particularly its cell-proliferation-promoting effects, hamper the development of selective/targeted therapies. For example, although AP-induced neurogenesis may serve to compensate neuronal loss in degenerative brains, AP-evoked cell-proliferation is contraindicated for steroid-sensitive cancer patients. To foster progress, we synthesised 4 novel AP analogues of neurosteroids (ANS) designated BR053 (12-oxo-epi-AP), BR297 (O-allyl-epi-AP), BR351 (O-allyl-AP) and BR338 (12-oxo-AP). First, because AP is well-known as allosteric modulator of GABAA receptors (GABAA-R), we used the electrophysiological patch-clamp technique to determine the structure-activity relationship of our ANS on GABAA-activated current in NCB20 cells expressing functional GABAA-R. We found that the addition of 12-oxo-group did not significantly change the respective positive or negative allosteric effects of 3α-AP or 3β-(epi)-AP analogues. Importantly, substitution of the 3α-hydroxyl-group by 3α-O-allyl highly modified the ANS activities. Unlike AP, BR351 induced a long-lasting desensitisation/inhibition of GABAA-R. Interestingly, replacement of the 3β-hydroxyl by 3β-O-allyl (BR297) completely reversed the activity from negative to positive allosteric action. In a second step, we compared the actions of AP and ANS on SH-SY5Y neuronal cell viability/proliferation using MTT-reduction assays. Different dose-response curves were demonstrated for AP and the ANS. By contrast to AP, BR297 was totally devoid of cell-proliferative effect. Finally, we compared AP and ANS abilities to protect against oxidative stress-induced neuronal death pivotally involved in neurodegenerative diseases. Both BR351 and BR297 had notable advantages over AP in protecting SH-SY5Y cells against oxidative stress-induced death. Thus, BR297 appears to be a potent neuroprotective compound devoid of cell-proliferative activity. Altogether, our results suggest promising perspectives for the development of neurosteroid-based selective and effective strategies against neuroendocrine and/or neurodegenerative disorders. © 2017 British Society for Neuroendocrinology.

Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle

PubMed Central

Agrawal, Tanvi; Schu, Peter; Medigeshi, Guruprasad R.

2013-01-01

Intracellular protein trafficking pathways are hijacked by viruses at various stages of viral life-cycle. Heterotetrameric adaptor protein complexes (APs) mediate vesicular trafficking at distinct intracellular sites and are essential for maintaining the organellar homeostasis. In the present study, we studied the effect of AP-1 and AP-3 deficiency on flavivirus infection in cells functionally lacking these proteins. We show that AP-1 and AP-3 participate in flavivirus life-cycle at distinct stages. AP-3-deficient cells showed delay in initiation of Japanese encephalitis virus and dengue virus RNA replication, which resulted in reduction of infectious virus production. AP-3 was found to colocalize with RNA replication compartments in infected wild-type cells. AP-1 deficiency affected later stages of dengue virus infection where increased intracellular accumulation of infectious virus was observed. Therefore, our results propose a novel role for AP-1 and AP-3 at distinct stages of infection of some of the RNA viruses. PMID:23657274

Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle.

PubMed

Agrawal, Tanvi; Schu, Peter; Medigeshi, Guruprasad R

2013-01-01

Intracellular protein trafficking pathways are hijacked by viruses at various stages of viral life-cycle. Heterotetrameric adaptor protein complexes (APs) mediate vesicular trafficking at distinct intracellular sites and are essential for maintaining the organellar homeostasis. In the present study, we studied the effect of AP-1 and AP-3 deficiency on flavivirus infection in cells functionally lacking these proteins. We show that AP-1 and AP-3 participate in flavivirus life-cycle at distinct stages. AP-3-deficient cells showed delay in initiation of Japanese encephalitis virus and dengue virus RNA replication, which resulted in reduction of infectious virus production. AP-3 was found to colocalize with RNA replication compartments in infected wild-type cells. AP-1 deficiency affected later stages of dengue virus infection where increased intracellular accumulation of infectious virus was observed. Therefore, our results propose a novel role for AP-1 and AP-3 at distinct stages of infection of some of the RNA viruses.

Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

FULLER, R.K.

1999-02-23

This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects.more » The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.« less

Adipocyte aminopeptidases in obesity and fasting.

PubMed

Alponti, Rafaela Fadoni; Silveira, Paulo Flavio

2015-11-05

This study checked the existence of a diverse array of aminopeptidase (AP) enzymes in high (HDM) and low (LDM) density microsomal and plasma membrane (MF) fractions from adipocytes of control, monosodium glutamate obese and food deprived rats. Gene expression was detected for ArgAP, AspAP, MetAP, and two AlaAP (APM and PSA). APM and PSA had the highest catalytic efficiency, whereas AspAP the highest affinity. Subcellular distribution of AP activities depended on metabolic status. Comparing catalytic levels, AspAP in HDM, LDM and MF was absent in obese and control under food deprivation; PSA in LDM was 3.5-times higher in obese than in normally fed control and control and obese under food deprivation; MetAP in MF was 4.5-times higher in obese than in food deprived obese. Data show new AP enzymes genetically expressed in subcellular compartments of adipocytes, three of them with altered catalytic levels that respond to whole-body energetic demands. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Modeling Incremental Initial Active Duty Continuation Probabilities in the Selected Marine Corps Reserve

DTIC Science & Technology

2014-03-01

Regression. 2nd ed. Hoboken, NJ: John Wiley & Sons, 2000. Lien, Dianna, Aline Quester, and Robert Shuford, Marine Corps Deployment Tempo and Retention...calhoun.nps.edu/public/bitstream/handle/10945/5778/11Mar_Lizarraga.pdf? sequence=1 Quester, Aline , Laura Kelley, Cathy Hiatt, and Robert Shoford. Marine

Lifelong Learning Research Conference Proceedings (9th, College Park, Maryland, February 25-26, 1988).

ERIC Educational Resources Information Center

Rivera, William M., Comp.; Davis, Cynthia, Comp.

The following 26 papers, with abstracts and references, are included in these proceedings: "Panel: Continuing Professional Education in Cooperative Extension" (Robert L. Bruce, G. L. Carter, Jr., Ronald Jimmerson, Joan S. Thomson); "New Farm Families: Implications for Extension Educators" (Jane W. McGonigal, Robert L. Bruce); "The Experience of…

Measuring What Matters: Robert Sternberg's Enlightened Approach to Admissions Testing

ERIC Educational Resources Information Center

Grace, Catherine O'Neill

2011-01-01

Psychologist Robert J. Sternberg's conviction that American standardized testing does not accurately reflect a child's intelligence or potential is far from theoretical. As an elementary school student in the 1950s, he scored poorly on the ubiquitous IQ test of the time, freezing up when the school psychologist entered the room. Thankfully for…

Best Practices and Provisional Guidelines for Integrating Mobile, Virtual, and Videogame-Based Training and Assessments

DTIC Science & Technology

2014-01-01

characteristics. (Doctoral dissertation, George Washington University , 2008). Dissertation Abstracts International , 70(11-A), 4257. *Swezey, R. W...Assessments Robert C. Brusso Robert A. Wisher Arthur Paddock Joshua Hatfield ICF International January 2014...Approved for public release: distribution is unlimited U.S. Army Research Institute for the

Librarian of the Year 1997: Bobby Roberts: Central Arkansas Library System.

ERIC Educational Resources Information Center

Berry, John N., III

1998-01-01

Presents Bobby Roberts, director of the Central Arkansas Library System (CALS), and describes some of the changes he has made since 1989: raising public library tax rates, doubling the book budget, library automation, new and renovated buildings, adult public programming, library cooperation, and fund raising. Discusses politics and the…

Dr. Robert Goddard

NASA Image and Video Library

2017-12-08

Dr. Robert Goddard's rocket ready for flight. Roswell, New Mexico. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

A Pedagogy of Sight: Microscopic Vision in Robert Hooke's "Micrographia"

ERIC Educational Resources Information Center

Jack, Jordynn

2009-01-01

Robert Hooke's "Micrographia" (1665) holds an important place in the history of scientific visual rhetoric. Hooke's accomplishment lies not only in a stunning array of engravings, but also in a "pedagogy of sight"--a rhetorical framework that instructs readers how to view images in accordance with an ideological or epistemic program. Hooke not…

75 FR 60861 - Qualification of Drivers; Exemption Renewals; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

..., Riche Ford, Kelly L. Foster, Kevin J. Friedel, Donald W. Garner, Paul W. Goebel, Jr., Ronnie L. Hanback... J. Lewis, Velmer L. McClelland, Larry McCoy, Sr., Robert W. McMillian, Danny W. Nuckles, Richard A..., Robert M. Stewart, John L. Stone, Nils S. Thornberg, Daniel W. Toppings, Kenneth E. Valentine...

The Ledger: Federal Reserve Bank of Boston's Economic Education Newsletter, 2001.

ERIC Educational Resources Information Center

Jabaily, Bob, Ed.

2001-01-01

The spring 2001 issue of "The Ledger" looks at economics and sports from the bicycle boom to the failure of the Xtreme Football League (XFL) today. Articles include: "The XFL and the WWF: Win Some, Lose Some" (Robert Wedge); "Major Taylor, Colonel Pope, and the General Commotion over Bicycles" (Robert Jabaily); and…

Servant Leadership: Robert K. Greenleaf's Legacy and the Community College.

ERIC Educational Resources Information Center

Shugart, Sanford

The term "servant leadership" involves putting people and ethical considerations intentionally ahead of short term institutional or personal self-interest. In the 1960s, Robert K. Greenleaf wrote the first of several books on servant leadership, arguing that institutions were both the glory and bane of modern society because they…

Charisma and Christianity: Is Jimmy Lee Swaggart a Cynic?

ERIC Educational Resources Information Center

Corder, Lloyd E.

Since the advent of cable television in the early seventies, the success of television evangelists including Oral Roberts, Jim Bakker, Robert Schuller, and Jimmy Swaggart has grown, both in terms of finances and in conversion of souls. Although many television preachers use similar strategies for getting donations, their backgrounds and messages…

[Roberts-SC phocomelia syndrome].

PubMed

Musfeld, D A; Bühler, E M; Heinzl, S

2001-01-01

The Roberts-SC phocomelia syndrome is a rare autosomal recessive inherited disorder clinically manifested by tetraphocomelia, pre- and postnatal growth retardation, and craniofacial abnormalities (skull, eyes, lip, and palate), accompanied at times by centromer puffing and splitting, renal abnormalities, heart defect, clitoral or penile enlargement, and bilateral corneal opacities. Mental retardation is common in surviving patients.

One of Sociology's Most Influential Scholars

ERIC Educational Resources Information Center

Chronicle of Higher Education, 2006

2006-01-01

Robert N. Bellah turns 80 early next year, and Duke University Press is honoring him with "The Robert Bellah Reader," edited by Bellah, an emeritus professor of sociology at the University of California at Berkeley, and Steven M. Tipton, a professor of sociology at Emory University. The book, just published, presents a selection of…

Response to Mudford, Hogg, and Roberts on Continuous Recording of Behavior State.

ERIC Educational Resources Information Center

Guess, Doug; Roberts, Sally; Behrens, Gene Ann; Rues, Jane

1998-01-01

Responds to a critique by Mudford, Hogg, and Roberts (1997) that raised concerns about the observation code used in a longitudinal research project to assess emerging behavior state patterns in young children with disabilities. Concerns about the thoroughness of the reliability data collected by Mudford are discussed. (Author/CR)

Speaking Personally--With Robert G. Holmberg

ERIC Educational Resources Information Center

American Journal of Distance Education, 2009

2009-01-01

This article presents an interview with Robert G. Holmberg, professor emeritus at Athabasca University (AU). He retired at the end of 2007 following a thirty-three-year academic career at AU in Edmonton and Athabasca, Alberta, Canada. During that time he oversaw the development and delivery of several of the university's first courses. He helped…

From High Finance to Highly Rewarding

ERIC Educational Resources Information Center

Valenzano, Joseph M., Jr.

2006-01-01

The author of this article talks to Robert Kreider about why helping people with special needs is so important to him and his colleagues. Robert Kreider is the president and chief executive officer of The Devereux Foundation, the nation's largest non-profit provider of behavioral healthcare services to children and adults with emotional,…

Influence of Marine Aviation on the Development of the Tentative Landing Operations Manual

DTIC Science & Technology

2013-06-13

Germans near the town of Stadenburg, Belgium. Captain Francis P. Mulcahy and Gunnery Sergeant Thomas L. McCullough, as well as Captain Robert S...its own aircraft and flew its first mission as a Marine aviation unit. Captain Robert S. Lytle led the mission to cripple the German held railroad

Acting Administrator Robert Lightfoot Discusses NASAs FY2018 NASA Budget Request

NASA Image and Video Library

2017-05-23

Acting NASA Administrator Robert Lightfoot discussed the agency’s Fiscal Year 2018 budget request on May 23, during an agencywide town hall State of NASA address at NASA Headquarters in Washington. The address also was broadcast on NASA Television and streamed on the agency’s homepage and mobile apps.

Education and Utopia: Robert Owen and Charles Fourier

ERIC Educational Resources Information Center

Leopold, David

2011-01-01

The aims of education, and the appropriate means of realising them, are a recurring preoccupation of utopian authors. The utopian socialists Robert Owen (1771-1858) and Charles Fourier (1772-1837) both place human nature at the core of their educational views, and both see education as central to their wider objective of social and political…

Naval Forces: Valuable Beyond the Sum of Their Parts

DTIC Science & Technology

1993-06-18

International, June 1983, p. 32. CHAPTER IV 1. Robert 0. Crawshaw , "What is a Maritime Action Group?" U.S. Naval Institute Proceedings, January 1993, p. 29...Corps Gazette, November 1992. Cable, James. Gunboat Diplomacy 1919-1979, St. Martins Press, New York, NY, 1981. Crawshaw , Robert 0. "What is a Maritime

Award for Distinguished Scientific Early Career Contributions to Psychology: Robert E. Ployhart

ERIC Educational Resources Information Center

American Psychologist, 2009

2009-01-01

Robert E. Ployhart, recipient of the Award for Distinguished Scientific Early Career Contributions to Psychology, is cited for innovative work in examining reactions to staffing practices and efforts to enhance the acceptability of recruitment and staffing practices; for exemplary use of applied statistical models in examining multilevel effects…

Robert B. Laughlin and the Fractional Quantum Hall Effect

Science.gov Websites

dropdown arrow Site Map A-Z Index Menu Synopsis Robert B. Laughlin and the Fractional Quantum Hall Effect Tsui discovered the effect. In 1983, Laughlin, then at the Lawrence Livermore National Laboratory , provided the theoretical explanation of the effect in terms of fractionally charged particles. It was a

77 FR 71853 - Self-Regulatory Organizations; BATS Exchange, Inc.; NASDAQ OMX BX Inc.; Chicago Board Options...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

..., Commission, dated October 18, 2012; Letter from J. Robert Brown, Jr., Director, Corporate & Commercial Law Program, University of Denver Sturm College of Law to Elizabeth M. Murphy, Secretary, Commission, dated..., dated November 14, 2012. \\6\\ See Letter from J. Robert Brown, Jr., Director, Corporate & Commercial Law...

The Virtual Employment Test Bed: An Immersive Synthetic Environment Allows Engineers to Test and Evaluate Material Solutions

DTIC Science & Technology

2014-04-03

synthetic environment allows engineers to test and evaluate material solutions Robert DeMarco, MSBME; Gordon Cooke, MEME ; John Riedener, MSSE...ROBERT DEMARCO, MSBME, is a Project Lead Engineer and Certified LabVIEW Associate Developer. GORDON COOKE, MEME , is a Principal Investigator at the

The Returns to Human Capital Migration within the Department of Defense Civilian Internal Labor Market

DTIC Science & Technology

2005-09-01

a period of time from year 1 to year T † From Ronald Ehrenberg and Robert Smith. Modern Labor Economics : Theory and...Economic Literature 13 (June): 397- 433. Ehrenberg, Ronald G. and Robert S. Smith. 2003. Modern Labor Economics : Theory and Public Policy. 8th ed

Wm. Lloyd Stackhouse & Robert E. Kinsman: A tale of two chiropractors

PubMed Central

Brown, Douglas M.

2013-01-01

This paper reviews the story of two childhood friends, Dr. Wm. Lloyd Stackhouse and Dr. Robert E. Kinsman, who attended the Canadian Memorial Chiropractic College (CMCC) together, graduated in 1953 to form an enduring partnership that included their immediate relatives, and to this day persists as a supportive tribe. PMID:23997249

Disengagement Operations: Context, Violence, and Spoilers in a New Phase IV Construct

DTIC Science & Technology

2010-05-21

disengagement from Operation 4 Robert M. Gates, “Gates Calls European Mood a Danger to Peace,” The New York Times, February 23, 2010; and Noam Chomsky ...September 2009. Chomsky , Noam. Failed States. New York: Metropolitan Books, 2006. Citino, Robert M. Blitzkrieg to Desert Storm: The Evolution of

Robert Owen: A Historiographic Study of a Pioneer of Human Resource Development

ERIC Educational Resources Information Center

Hatcher, Tim

2013-01-01

Purpose: The purpose of this paper is to investigate the ideals and activities of the nineteenth century Welsh industrialist and reformer Robert Owen (1771-1858), and how they informed modern human resource development (HRD) concepts and practices and provided evidence of Owen as a HRD pioneer. Design/methodology/approach: Historiography provided…

Note on Conditional Compilation in Standard ML

DTIC Science & Technology

1993-06-01

eOmputer-Science No-te on Coridhitiom Cominliati"I~n Standard ML1 Nicholas Haines Edoardo Biagioni Robert Hiarper mom Brian G. Mimnes June 1993 CMU...CS-93. 11 TIC ELECTE f 00..7733 %goo~~OO Note on Conditioual Compilation in Standard ML Nicholas Haines Edoardo Biagioni Robert Harper Brian G. Milnes

Schools Can be Made Better: The Ideas, Models, and Tools of Robert Fox.

ERIC Educational Resources Information Center

Lippitt, Ronald; Johnson, Patricia L.

The humanistic ideas, models, and tools of educator Robert Fox are presented in eight chapters. Chapter I summarizes Fox's ideas toward clarifying values, projecting possible goals and plans toward humane education, the balance and linkage between intellectual, socio-emotional, and citizenship development, the individualization of curriculum, and…

PRESS CONFERENCE - GEMINI-TITAN (GT)-11 - MSC

NASA Image and Video Library

1966-08-01

S66-39895 (1 Aug. 1966) --- Panel members of the Gemini-10 news conference held in the Building 1 auditorium were (from left) Dr. Robert C. Seamans Jr., NASA Deputy Administrator; astronaut John W. Young, Gemini-10 command pilot; astronaut Michael Collins, Gemini-10 pilot; and Dr. Robert R. Gilruth, MSC Director. Photo credit: NASA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eisses, A.; Kell, A.; Kent, G.

Amy Eisses, Annie M. Kell, Graham Kent, Neal W. Driscoll, Robert E. Karlin, Robert L. Baskin, John N. Louie, Kenneth D. Smith, Sathish Pullammanappallil, 2011, Marine and land active-source seismic investigation of geothermal potential, tectonic structure, and earthquake hazards in Pyramid Lake, Nevada: presented at American Geophysical Union Fall Meeting, San Francisco, Dec. 5-9, abstract NS14A-08.

Management Perspectives Pertaining to Root Cause Analyses of Nunn-McCurdy Breaches: Contractor Motivations and Anticipating Breaches, Volume 6

DTIC Science & Technology

2014-01-01

a similar problem. See Robert Jackall , Moral Mazes: The World of Corporate Managers, London: Oxford University Press, 2009. Contractor Incentives...Night Vision Goggles,” ITT Corporation press release, April 4, 2011. Jackall , Robert, Moral Mazes: The World of Corporate Managers, London: Oxford

Percy Julian, Robert Robinson, and the Identity of Eserethole

ERIC Educational Resources Information Center

Ault, Addison

2008-01-01

The Nova production "Percy Julian--Forgotten Genius" included the very public disagreement between Percy Julian, an unknown American chemist, and Robert Robinson, possibly the best known organic chemist of the day, as to the identity of "eserethole", the key intermediate for the synthesis of the alkaloid physostigmine. The Nova production,…

Research, Learning Theory, and the Ideas of Robert G. Sidnell. Special Issue.

ERIC Educational Resources Information Center

Alexander, David, Ed.; And Others

1987-01-01

Intended as a memorial to Robert G. Sidnell, this special issue contains articles about areas of music education which he promoted. In "The Dimensions of Research in Music Education," Sidnell concluded that music education research encompasses all humanistic disciplines as well as the behavioral and social sciences. James Carlsen, in…

Pygmalion Effect on Junior English Teaching

ERIC Educational Resources Information Center

Wang, Yurong; Lin, Li

2014-01-01

Pygmalion Effect, or Robert Rosenthal Effect, was proved by the famous American psychologist Robert Rosenthal and Jacobson in 1968. Pygmalion Effect, as a matter of fact, is a psychological suggestion, which believes that people can accept the influence and suggestion given by the people whom very much they admire, like, believe, and respect. This…

Tuskegee's Robert R. Moton and the Travails of the Early Black College President.

ERIC Educational Resources Information Center

Fairclough, Adam

2001-01-01

Presidents of historically black colleges were once expected to teach their students that they would advance through industrial education and the benevolent guidance of white foundations funding the schools. Focuses on Tuskegee Institute's Robert Moton, who accommodated to southern segregation but never accepted the racist rationale for Jim Crow…

1. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, ORIGINAL HOUSE ('Fig. 5-A') - J. G. Vawter House, First Avenue & South Street, Winterset, Madison County, IA

4. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, THIRD ADDITION ('Fig. 5-D') - J. G. Vawter House, First Avenue & South Street, Winterset, Madison County, IA

3. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, SECOND ADDITION ('Fig. 5-C') - J. G. Vawter House, First Avenue & South Street, Winterset, Madison County, IA

2. Photocopy of measured drawing (from Robert R. Harvey's 'Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of measured drawing (from Robert R. Harvey's 'Historic Stone Architecture of Winterset, Iowa, Prior To and During the Civil War Period,' Unpublished Report, Iowa State University, (Ames, IA), 1960.) FLOOR PLAN, SHOWING FIRST ADDITION ('Fig. 5-B') - J. G. Vawter House, First Avenue & South Street, Winterset, Madison County, IA

Evaluation Policy in a Nonprofit Foundation: A Case Study Exploration of the Robert Wood Johnson Foundation

ERIC Educational Resources Information Center

Dillman, Lisa M.; Christie, Christina A.

2017-01-01

This study explores the relationship between evaluation policies and evaluation practice. Through document analysis, interviews, and a multiple case study, the research examined the explicit and implicit policies overarching the evaluation work commissioned by the Robert Wood Johnson Foundation (RWJF) and explored how these policies are…

The Tree Man: Robert Mazibuko's Story.

ERIC Educational Resources Information Center

Bloch, Joanne, Ed.

This book for beginning readers highlights Robert Mazibuko, the "Tree Man," who spent his life teaching people how to enrich the soil and plant vegetables and trees. Born in South Africa in 1904, he lived on a farm, learning to work with livestock, raise crops, and share with the community. In college, his professor of agriculture…

At Home in the Natural World

ERIC Educational Resources Information Center

Roberts, Jim

2013-01-01

Jim Roberts captures the challenges of walking with small groups of children under six, building confidence in bushwhacking trails, and walking on brambles. Mr. Roberts gives many clues as to indirect teaching moments while enjoying the ramble with an emphasis on opening the sensory pathways without the clutter of names, which can often give young…

Biodegradation of an Organophosphate Chemical Warfare Agent Simulant by Activated Sludge with Varying Solid Retention Times

DTIC Science & Technology

2013-03-21

cause a response in the membrane (Robert, 1992). The transmitter must then be quickly removed to prevent abnormal excitation of the membranes (Robert...Health, 95(8), 1382-1388. Chapman, S., Kadar, T., & Gilat, E. (2006). Seizure duration following sarin exposure affects neuro -inflammatory markers

Reframing Afghanistan: Is Operational Planning Linked to History and Culture?

DTIC Science & Technology

2012-05-17

serenity . Zakah purifies one’s wealth by sharing 2.5 percent of one’s wealth annually with those less fortunate and mitigates envy between classes... serene .ච Instead, Jan offered Roberts unmolested passage to India, seeking to avoid a difficult fight while returning Yaqub to power. Roberts refused

Terminal Blackout: Critical Electric Infrastructure Vulnerabilities and Civil-Military Resiliency

DTIC Science & Technology

2013-10-01

William R. Graham, Robert J. Hermann, Henry M. Kluepfel, Richard L. Lawson, Gordon K. Soper , Lowell L. Wood, Jr., and Joan B. Woodard, Report of the...R. Graham, Robert J. Hermann, Henry M. Kluepfel, Richard L. Lawson, Gordon K. Soper , Lowell L. Wood, Jr., and Joan B. Woodard, Report of the

78 FR 64232 - North Carolina; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

... authority of the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the... Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

77 FR 20044 - West Virginia; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the ``Stafford... under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq. (the... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

76 FR 72965 - District of Columbia; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... authority of the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 42 U.S.C. 5121 et seq... severity and magnitude to warrant a major disaster declaration under the Robert T. Stafford Disaster Relief... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

Increasing Small Arms Lethality in Afghanistan Taking Back the Infantry Half-Kilometer

DTIC Science & Technology

2009-05-21

John A. Malinowski , and Robert E. Bowen. "Bullet Fragmentation: A Major Cause of Tissue Disruption." JTrauma, 1984: 35-39. 67 Initial muzzle...Fackler, Martin L, M.D., M.A. John S. Surinchak, B.S. John A. Malinowski , and Robert E. Bowen. "Bullet Fragmentation: A Major Cause of Tissue

Underwater views of STS-11 crewman Robert L. Stewart during EVA training

NASA Technical Reports Server (NTRS)

1983-01-01

Underwater views of STS-11 crewman Robert L. Stewart during extravehicular activity (EVA) training in the cargo bay in the weightless environment training facility (WETF) in bldg 27. Stewart busies himself with donning and doffing of the manned maneuvering unit (MMU) in a mockup of the Shuttle's cargo bay.

Special report. Designing security for a garage serving a new medical school: from concept to reality.

PubMed

1997-01-01

The Paterson Street Deck, New Brunswick, NJ, cited by the International Parking Institute (IPI) for excellence in design, employs a number of modern security concepts to protect its customers. The deck was built by the New Brunswick Parking Authority, which worked with the city's medical community to develop the 1,010-space structure located next to the newly built Robert Wood Johnson Medical School. The spaces are used by approximately 800 medical patrons--students of the medical school and employees of Robert Wood Johnson University Hospital, as well as an additional 200 visitors. Staffers and students pay for parking services biweekly on a graduated scale based on the level of their job title, according to Joseph Bernasz, director of administrator, Robert Wood Johnson Medical School. And they have been very receptive to the new facility, says Kevin McTernan, vice president of administrative services, Robert Wood Johnson University Hospital, New Brunswick. In this report, we'll present in detail the security concepts employed, the reasons behind them, and how they have been employed since the deck opened about two years ago.

Sulfate-activating enzymes of Penicillium chrysogenum. The ATP sulfurylase. adenosine 5'-phosphosulfate complex does not serve as a substrate for adenosine 5'-phosphosulfate kinase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renosto, F.; Martin, R.L.; Segel, I.H.

1989-06-05

At a noninhibitory steady state concentration of adenosine 5'-phosphosulfate (APS), increasing the concentration of Penicillium chrysogenum ATP sulfurylase drives the rate of the APS kinase-catalyzed reaction toward zero. The result indicates that the ATP sulfurylase.APS complex does not serve as a substrate for APS kinase, i.e. there is no ''substrate channeling'' of APS between the two sulfate-activating enzymes. APS kinase had no effect on the (S)0.5 values, nH values, or maximum isotope trapping in the single turnover of ATP sulfurylase-bound (/sup 35/S)APS. Equimolar APS kinase (+/- MgATP or APS) also had no effect on the rate constants for the inactivationmore » of ATP sulfurylase by phenylglyoxal, diethylpyrocarbonate, or N-ethylmaleimide. Similarly, ATP sulfurylase (+/- ligands) had no effect on the inactivation of equimolar APS kinase by trinitrobenzene sulfonate, diethylpyrocarbonate, or heat. (The last promotes the dissociation of dimeric APS kinase to inactive monomers.) ATP sulfurylase also had no effect on the reassociation of APS kinase subunits at low temperature. The cumulative results suggest that the two sulfate activating enzymes do not associate to form a ''3'-phosphoadenosine 5'-phosphosulfate synthetase'' complex.« less

Long-term prognostic impact of the attenuated plaque in patients with acute coronary syndrome.

PubMed

Okura, Hiroyuki; Kataoka, Toru; Yoshiyama, Minoru; Yoshikawa, Junichi; Yoshida, Kiyoshi

2016-01-01

Several intravascular ultrasound studies have reported that culprit lesion-attenuated plaque (AP) is related to slow flow/no reflow after percutaneous coronary intervention (PCI). Long-term prognostic impact of the AP is unknown. The aim of this study was to investigate acute and long-term clinical impact of the AP in patients with acute coronary syndrome (ACS). A total of 110 ACS patients who underwent successful PCI were enrolled. Acute and long-term clinical outcomes were compared between patients with AP (AP group: n = 73) and those without AP (non-AP group: n = 37). Long-term cardiac event was defined as a composite of death and ACS. Baseline characteristics in 2 groups were similar. AP was associated with higher TIMI frame count immediately after the first balloon inflation. After thrombectomy and intracoronary drug administration, final TIMI frame count became similar between AP and non-AP group. Although AP was associated with higher incidence of fatal arrhythmia during hospitalization, in-hospital mortality did not differ between the 2 groups. During follow-up (median 6.2 years), cardiac event-free survival did not differ between the 2 groups. Despite the initial unfavorable effect on coronary reflow, presence of AP did not affect acute as well as long-term clinical outcome in patients with ACS.

Thrombopoietin as Early Biomarker of Disease Severity in Patients With Acute Pancreatitis.

PubMed

Lupia, Enrico; Pigozzi, Luca; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Loiacono, Maria; Lucchiari, Manuela; Battista, Stefania; Morello, Fulvio; Moiraghi, Corrado; Mengozzi, Giulio; Montrucchio, Giuseppe

2017-02-01

To study the concentrations of thrombopoietin (TPO), a growth factor recently involved in the pathogenesis of experimental acute pancreatitis (AP), and its potential role as an early diagnostic and prognostic biomarker in patients with AP. Thrombopoietin was measured in 44 AP patients, 18 patients with nonpancreatic acute abdominal pain, and 18 healthy volunteers. Acute pancreatitis severity was classified on the basis of the 2012 International Atlanta Symposium on Acute Pancreatitis criteria. Thrombopoietin levels did not differ between AP patients and control subjects, whereas these were higher in patients with moderately severe or severe AP compared with those with mild AP. Receiver operating characteristic curve analysis of TPO for severe AP diagnosis showed an area under the curve of 0.80. A cutoff value of 31.48 pg/mL showed the highest sensitivity, allowing to rule out severe AP when TPO was lower, whereas TPO higher than 98.23 pg/mL was associated with severe AP with high specificity (93.5%). Furthermore, TPO levels were greater in AP patients developing organ dysfunction or sepsis and in nonsurvivors compared with survivors. Our data provide the first evidence for TPO as potential early prognostic biomarker in AP patients. High TPO levels at hospital admission may predict organ dysfunction, sepsis, and fatal outcome in AP patients.

Stimulatory effect of exogenous diadenosine tetraphosphate on insulin and glucagon secretion in the perfused rat pancreas

PubMed Central

Silvestre, Ramona A; Rodríguez-Gallardo, Jovita; Egido, Eva M; Marco, José

1999-01-01

Diadenosine triphosphate (AP3A) and diadenosine tetraphosphate (AP4A) are released by various cells (e.g. platelets and chromaffin cells), and may act as extracellular messengers. In pancreatic B-cells, AP3A and AP4A are inhibitors of the ATP-regulated K+ channels, and glucose increases intracellular levels of both substances.We have studied the effect of exogenous AP3A and AP4A on insulin and glucagon secretion by the perfused rat pancreas.AP3A did not significantly modify insulin or glucagon release, whereas AP4A induced a prompt, short-lived insulin response (≈4 fold higher than basal value; P<0.05) in pancreases perfused at different glucose concentrations (3.2, 5.5 or 9 mM). AP4A-induced insulin release was abolished by somatostatin and by diazoxide. These two substances share the capacity to activate ATP-dependent K+ channels, suggesting that these channels are a potential target for AP4A in the B-cell.AP4A stimulated glucagon release at both 3.2 and 5.5 mM glucose. This effect was abolished by somatostatin.The results suggest that extracellular AP4A may play a physiological role in the control of insulin and glucagon secretion. PMID:10516664

Stimulatory effect of exogenous diadenosine tetraphosphate on insulin and glucagon secretion in the perfused rat pancreas.

PubMed

Silvestre, R A; Rodríguez-Gallardo, J; Egido, E M; Marco, J

1999-10-01

1. Diadenosine triphosphate (AP3A) and diadenosine tetraphosphate (AP4A) are released by various cells (e.g. platelets and chromaffin cells), and may act as extracellular messengers. In pancreatic B-cells, AP3A and AP4A are inhibitors of the ATP-regulated K+ channels, and glucose increases intracellular levels of both substances. 2. We have studied the effect of exogenous AP3A and AP4A on insulin and glucagon secretion by the perfused rat pancreas. 3. AP3A did not significantly modify insulin or glucagon release, whereas AP4A induced a prompt, short-lived insulin response ( approximately 4 fold higher than basal value; P<0.05) in pancreases perfused at different glucose concentrations (3.2, 5.5 or 9 mM). AP4A-induced insulin release was abolished by somatostatin and by diazoxide. These two substances share the capacity to activate ATP-dependent K+ channels, suggesting that these channels are a potential target for AP4A in the B-cell. 4. AP4A stimulated glucagon release at both 3.2 and 5.5 mM glucose. This effect was abolished by somatostatin. 5. The results suggest that extracellular AP4A may play a physiological role in the control of insulin and glucagon secretion.

Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly

PubMed Central

Hardies, Katia; May, Patrick; Djémié, Tania; Tarta-Arsene, Oana; Deconinck, Tine; Craiu, Dana; Helbig, Ingo; Suls, Arvid; Balling, Rudy; Weckhuysen, Sarah; De Jonghe, Peter; Hirst, Jennifer; Afawi, Zaid; Barisic, Nina; Baulac, Stéphanie; Caglayan, Hande; Depienne, Christel; De Kovel, Carolien G.F.; Dimova, Petia; Guerrero-López, Rosa; Guerrini, Renzo; Hjalgrim, Helle; Hoffman-Zacharska, Dorota; Jahn, Johanna; Klein, Karl Martin; Koeleman, Bobby P.C.; Leguern, Eric; Lehesjoki, Anna-Elina; Lemke, Johannes; Lerche, Holger; Marini, Carla; Muhle, Hiltrud; Rosenow, Felix; Serratosa, Jose M.; Møller, Rikke S.; Stephani, Ulrich; Striano, Pasquale; Talvik, Tiina; Von Spiczak, Sarah; Weber, Yvonne; Zara, Federico

2015-01-01

We report two siblings with infantile onset seizures, severe developmental delay and spastic paraplegia, in whom whole-genome sequencing revealed compound heterozygous mutations in the AP4S1 gene, encoding the σ subunit of the adaptor protein complex 4 (AP-4). The effect of the predicted loss-of-function variants (p.Gln46Profs*9 and p.Arg97*) was further investigated in a patient's fibroblast cell line. We show that the premature stop mutations in AP4S1 result in a reduction of all AP-4 subunits and loss of AP-4 complex assembly. Recruitment of the AP-4 accessory protein tepsin, to the membrane was also abolished. In retrospect, the clinical phenotype in the family is consistent with previous reports of the AP-4 deficiency syndrome. Our study reports the second family with mutations in AP4S1 and describes the first two patients with loss of AP4S1 and seizures. We further discuss seizure phenotypes in reported patients, highlighting that seizures are part of the clinical manifestation of the AP-4 deficiency syndrome. We also hypothesize that endosomal trafficking is a common theme between heritable spastic paraplegia and some inherited epilepsies. PMID:25552650

Molecular cloning and functional characterization of multiple NADPH-cytochrome P450 reductases from Andrographis paniculata.

PubMed

Lin, Huixin; Wang, Jian; Qi, Mengdie; Guo, Juan; Rong, Qixian; Tang, Jinfu; Wu, Yisheng; Ma, Xiaojing; Huang, Luqi

2017-09-01

Andrographis paniculata (Burm.f.) Wall. ex Nees is widely used as medicinal herb in Southern and Southeastern Asia and andrographolide is its main medicinal constituent. Based on the structure of andrographolide, it has been proposed that cytochrome P450 enzymes play vital roles on its biosynthesis. NADPH:cytochrome P450 reductase (CPR) is the most important redox partner of multiple P450s. In this study, three CPRs were identified in the genomic data of A. paniculata (namely ApCPR1, ApCPR2, and ApCPR3), and their coding regions were cloned. They varied from 62% to 70% identities to each other at the amino acid sequence level. ApCPR1 belongs to Class I of dicotyledonous CPR while both ApCPR2 and ApCPR3 are grouped to Class II. The recombinant enzymes ApCPR1 and ApCPR2 reduced cytochrome c and ferricyanide in an NADPH-dependent manner. In yeast, they supported the activity of CYP76AH1, a ferruginol-forming enzyme. However, ApCPR3 did not show any enzymatic activities either in vitro or in vivo. Quantitative real-time PCR analysis showed that both ApCPR1 and ApCPR2 expressed in all tissues examined, but ApCPR2 showed higher expression in leaves. Expression of ApCPR2 was inducible by MeJA and its pattern matched with andrographolide accumulation. Present investigation suggested ApCPR2 involves in the biosynthesis of secondary metabolites including andrographolide. Copyright © 2017. Published by Elsevier B.V.

Mannose-coated gadolinium liposomes for improved magnetic resonance imaging in acute pancreatitis.

PubMed

Tian, Bing; Liu, Ri; Chen, Shiyue; Chen, Luguang; Liu, Fang; Jia, Guorong; Dong, Yinmei; Li, Jing; Chen, Huaiwen; Lu, Jianping

2017-01-01

Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas. The symptoms, treatment, and prognosis of mild and severe AP are different, and severe AP is a potentially life-threatening disease with a high incidence of complications and high mortality rate. Thus, it is urgent to develop an effective approach to reliably discriminate between mild and severe AP. We have developed novel gadolinium-diethylenetriaminepentaacetic (Gd-DTPA)-loaded mannosylated liposomes (named thereafter M-Gd-NL) that preferably target macrophages in AP. The targeting ability of M-Gd-NL toward macrophages in AP and its ability to discriminate between mild and severe AP were evaluated. The liposomes were of desired particle size (~100 nm), Gd-DTPA encapsulation efficiency (~85%), and stability. M-Gd-NL and non-targeted Gd-DTPA-loaded liposomes (Gd-NL) exhibited increased relaxivity compared with Gd-DTPA. Compared with Gd-NL and Gd-DTPA, M-Gd-NL showed increased uptake in macrophages, resulting in increased T 1 imaging ability both in vitro (macrophage cell line) and in vivo (severe AP model). Importantly, M-Gd-NL had the ability to discriminate between mild and severe AP, as reflected by a significantly higher T 1 magnetic resonance imaging signal in severe AP than in mild AP. M-Gd-NL did not show severe organ toxicity in rats. Our data suggest that M-Gd-NL had enhanced magnetic resonance imaging ability by targeting macrophages in AP and good ability to discriminate between mild and severe AP. We believe that M-Gd-NL could shed new light on the diagnosis of AP in the near future.

Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

PubMed Central

Mortensen, Franziska; Schneider, Daniel; Barbic, Tanja; Sladewska-Marquardt, Anna; Kühnle, Simone; Marx, Andreas; Scheffner, Martin

2015-01-01

Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been associated with three different clinical pictures. Hijacking of E6AP by the E6 oncoprotein of distinct human papillomaviruses (HPV) contributes to the development of cervical cancer, whereas loss of E6AP expression or function is the cause of Angelman syndrome, a neurodevelopmental disorder, and increased expression of E6AP has been involved in autism spectrum disorders. Although these observations indicate that the activity of E6AP has to be tightly controlled, only little is known about how E6AP is regulated at the posttranslational level. Here, we provide evidence that the hydrophobic patch of ubiquitin comprising Leu-8 and Ile-44 is important for E6AP-mediated ubiquitination, whereas it does not affect the catalytic properties of the isolated catalytic HECT domain of E6AP. Furthermore, we show that the HPV E6 oncoprotein rescues the disability of full-length E6AP to use a respective hydrophobic patch mutant of ubiquitin for ubiquitination and that it stimulates E6AP-mediated ubiquitination of Ring1B, a known substrate of E6AP, in vitro and in cells. Based on these data, we propose that E6AP exists in at least two different states, an active and a less active or latent one, and that the activity of E6AP is controlled by noncovalent interactions with ubiquitin and allosteric activators such as the HPV E6 oncoprotein. PMID:26216987

Genome-wide identification, evolutionary and expression analysis of the aspartic protease gene superfamily in grape

PubMed Central

2013-01-01

Background Aspartic proteases (APs) are a large family of proteolytic enzymes found in almost all organisms. In plants, they are involved in many biological processes, such as senescence, stress responses, programmed cell death, and reproduction. Prior to the present study, no grape AP gene(s) had been reported, and their research on woody species was very limited. Results In this study, a total of 50 AP genes (VvAP) were identified in the grape genome, among which 30 contained the complete ASP domain. Synteny analysis within grape indicated that segmental and tandem duplication events contributed to the expansion of the grape AP family. Additional analysis between grape and Arabidopsis demonstrated that several grape AP genes were found in the corresponding syntenic blocks of Arabidopsis, suggesting that these genes arose before the divergence of grape and Arabidopsis. Phylogenetic relationships of the 30 VvAPs with the complete ASP domain and their Arabidopsis orthologs, as well as their gene and protein features were analyzed and their cellular localization was predicted. Moreover, expression profiles of VvAP genes in six different tissues were determined, and their transcript abundance under various stresses and hormone treatments were measured. Twenty-seven VvAP genes were expressed in at least one of the six tissues examined; nineteen VvAPs responded to at least one abiotic stress, 12 VvAPs responded to powdery mildew infection, and most of the VvAPs responded to SA and ABA treatments. Furthermore, integrated synteny and phylogenetic analysis identified orthologous AP genes between grape and Arabidopsis, providing a unique starting point for investigating the function of grape AP genes. Conclusions The genome-wide identification, evolutionary and expression analyses of grape AP genes provide a framework for future analysis of AP genes in defining their roles during stress response. Integrated synteny and phylogenetic analyses provide novel insight into the functions of less well-studied genes using information from their better understood orthologs. PMID:23945092

Unusual interaction of human apurinic/apyrimidinic endonuclease 1 (APE1) with abasic sites via the Schiff-base-dependent mechanism.

PubMed

Ilina, Ekaterina S; Khodyreva, Svetlana N; Lavrik, Olga I

2018-05-03

Clustered apurinic/apyrimidinic (AP) sites are more cytotoxic than isolated AP lesions because double strand breaks (DSB) can be formed during repair of closely positioned bistranded AP sites. Formation of DSB due to simultaneous cleavage of bistranded AP sites may be regulated by proteins specifically interacting with this complex lesion. A set of AP DNA duplexes containing AP sites in both strands in different mutual orientation (BS-AP DNAs) was used for search in the extracts of human cells proteins specifically recognizing clustered AP sites. A protein, which formed the Schiff-base-dependent covalent products having an apparent molecular mass of 50 kDa with the subset of BS-AP DNAs, was identified by mass spectrometry as apurinic/apyrimidinic endonuclease 1 (APE1). The identity of trapped protein was confirmed by Western blot analysis with anti-APE1 antibodies. Purified recombinant human APE1 is also capable of forming the 50 kDa-adducts with efficiency of BS-AP DNAs cross-linking to APE1 being dependent on the mutual orientation of AP sites. In spite of formation of the Schiff-base-dependent intermediate, which is prerequisite for the β-elimination mechanism, APE1 is unable to cleave AP sites. APE1 lacking the first 34 amino acids at the N-terminus, unlike wild type enzyme, is unable to form cross-links with BS-AP DNAs that testifies to the involvement of disordered N-terminal extension, which is enriched in lysine residues, in the interaction with AP sites. The yield of APE1-AP DNA cross-links was found to correlate with the enzyme amount in the extracts estimated by the immunochemical approach; therefore the BS-AP DNA-probes can be useful for comparative analysis of APE1 content in cell extracts. Copyright © 2018. Published by Elsevier B.V.

78 FR 4129 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... regulatory and law enforcement issues with officers and field offices. Information & Education AP Agenda... of the South Atlantic Fishery Management Council's Information & Education Advisory Panel (AP); Law Enforcement AP; Joint Meeting of the Information & Education AP and Law Enforcement AP; and meeting of the...

Power Saving Control for Battery-Powered Portable WLAN APs

NASA Astrophysics Data System (ADS)

Ogawa, Masakatsu; Hiraguri, Takefumi

This paper proposes a power saving control function for battery-powered portable wireless LAN (WLAN) access points (APs) to extend the battery life. The IEEE802.11 standard does not support power saving control for APs. To enable a sleep state for an AP, the AP forces the stations (STAs) to refrain from transmitting frames using the network allocation vector (NAV) while the AP is sleeping. Thus the sleep state for the AP can be employed without causing frame loss at the STAs. Numerical analysis and computer simulation reveal that the newly proposed control technique conserves power compared to the conventional control.

An Investigation of Experimental Techniques for Obtaining Particulate Behavior in Metallized Solid Propellant Combustion.

DTIC Science & Technology

1984-02-01

Additive Particle Size Propellant Binder Oxidizer Metal Mean Metal Diameter, Designation % Weight % Weight* % Weight Microns WGS-5A HTPB 12 AP 83 AL 5 75...88 4 WGS-6A HTPB 12 AP 83 AL 5 45-62 WGS-7A HTPB 12 AP 83 AL 5 23-37 WGS-7 HTPB 12 AP 83 AL 5 6-7 WGS-9 HTPB 12 AP 78 AL 10 23-27 WGS-1O HTPB 12 AP 73...AL 15 23-27 WGS-ZrC HTPB 14 AP 84 ZrC 2 23, irregularly shaped WGS-G HTPB 14 AP 84 G 2 50x20x7, flakes * 65% 180 jim/35% 26 tim These propellants

Mechanism of aminopyridine-induced release of [3H]dopamine from rat brain synaptosomes.

PubMed

Scheer, H W; Lavoie, P A

1991-01-01

1. Aminopyridines (APs) induced the release of [3H]dopamine (3H-DA) from rat synaptosomal preparations. 2. 4-AP and 3,4-DAP were of equal efficacy in inducing release of 3H-DA; 3-AP, 2-AP and 2,6-AP were less active; pyridine and pyridine-4-carboxylamide were inactive. 3. Cd2+ was more effective in inhibiting 4-AP-induced release of 3H-DA (IC50 approximately 4 microM) than Co2+ and Ni2+ (IC50s approximately 500 microM). 4. While 4-AP increased the 45Ca2+ content of whole synaptosomal preparations, no effect of 4-AP on 45Ca2+ content was observed in lysed synaptosomal preparations. 5. 4-AP-induced 45Ca2+ uptake was inhibited by Cd2+, Ni2+ and Co2+ in concentration ranges similar to those inhibiting 3H-DA release.

Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

PubMed Central

Zhang, Feiran; Bhat, Shridhar; Gabelli, Sandra B.; Chen, Xiaochun; Miller, Michelle S.; Nacev, Benjamin A.; Cheng, Yim Ling; Meyers, David J.; Tenney, Karen; Shim, Joong Sup; Crews, Phillip; Amzel, L. Mario; Ma, Dawei; Liu, Jun O.

2013-01-01

Methionine aminopeptidases (MetAPs) which remove the initiator methionine from nascent peptides are essential in all organisms. While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation. Our earlier efforts identified two structural classes of human MetAP1 (HsMetAP1)-selective inhibitors (1–4). But all of them failed to inhibit cellular HsMetAP1. Using Mn(II) or Zn(II) to activate HsMetAP1, we found that 1–4 could only effectively inhibit purified HsMetAP1 in the presence of physiologically unachievable concentrations of Co(II). In an effort to seek Co(II)-independent inhibitors, a novel structural class containing a 2-(pyridin-2-yl)quinazoline core has been discovered. Many compounds in this class potently and selectively inhibited HsMetAP1 without Co(II). Subsequently, we demonstrated that 11j, an auxiliary metal-dependent inhibitor, effectively inhibited HsMetAP1 in primary cells. This is the first report that an HsMetAP1-selective inhibitor is effective against its target in cells. PMID:23634668

Comparison of expression and enzymatic properties of Aspergillus oryzae lysine aminopeptidases ApsA and ApsB.

PubMed

Marui, Junichiro; Matsushita-Morita, Mayumi; Tada, Sawaki; Hattori, Ryota; Suzuki, Satoshi; Amano, Hitoshi; Ishida, Hiroki; Yamagata, Youhei; Takeuchi, Michio; Kusumoto, Ken-Ichi

2012-08-01

The apsA and apsB genes encoding family M1 aminopeptidases were identified in the industrial fungus Aspergillus oryzae. The apsB was transcriptionally up-regulated up to 2.5-fold in response to the deprivation of nitrogen or carbon sources in growth media, while up-regulation of apsA was less significant. The encoded proteins were bacterially expressed and purified to characterize their enzymatic properties. ApsA and ApsB were optimally active at pH 7.0 and 35 °C and stable at pH ranges of 6-10 and 4-10, respectively, up to 40 °C. The enzymes were inhibited by bestatin and EDTA, as has been reported for family M1 aminopeptidases that characteristically contain a zinc-binding catalytic motif. Both enzymes preferentially liberated N-terminal lysine, which is an essential amino acid and an important additive to animal feed. Enzymes that efficiently release N-terminal lysine from peptides could be useful for food and forage industries. Examination of the reactivity toward peptide substrate of varying length revealed that ApsB exhibited broader substrate specificity than ApsA although the reactivity of ApsB decreased as the length of peptide substrate decreased.

Action Potential Energy Efficiency Varies Among Neuron Types in Vertebrates and Invertebrates

PubMed Central

Sengupta, Biswa; Stemmler, Martin; Laughlin, Simon B.; Niven, Jeremy E.

2010-01-01

The initiation and propagation of action potentials (APs) places high demands on the energetic resources of neural tissue. Each AP forces ATP-driven ion pumps to work harder to restore the ionic concentration gradients, thus consuming more energy. Here, we ask whether the ionic currents underlying the AP can be predicted theoretically from the principle of minimum energy consumption. A long-held supposition that APs are energetically wasteful, based on theoretical analysis of the squid giant axon AP, has recently been overturned by studies that measured the currents contributing to the AP in several mammalian neurons. In the single compartment models studied here, AP energy consumption varies greatly among vertebrate and invertebrate neurons, with several mammalian neuron models using close to the capacitive minimum of energy needed. Strikingly, energy consumption can increase by more than ten-fold simply by changing the overlap of the Na+ and K+ currents during the AP without changing the APs shape. As a consequence, the height and width of the AP are poor predictors of energy consumption. In the Hodgkin–Huxley model of the squid axon, optimizing the kinetics or number of Na+ and K+ channels can whittle down the number of ATP molecules needed for each AP by a factor of four. In contrast to the squid AP, the temporal profile of the currents underlying APs of some mammalian neurons are nearly perfectly matched to the optimized properties of ionic conductances so as to minimize the ATP cost. PMID:20617202

Action potential energy efficiency varies among neuron types in vertebrates and invertebrates.

PubMed

Sengupta, Biswa; Stemmler, Martin; Laughlin, Simon B; Niven, Jeremy E

2010-07-01

The initiation and propagation of action potentials (APs) places high demands on the energetic resources of neural tissue. Each AP forces ATP-driven ion pumps to work harder to restore the ionic concentration gradients, thus consuming more energy. Here, we ask whether the ionic currents underlying the AP can be predicted theoretically from the principle of minimum energy consumption. A long-held supposition that APs are energetically wasteful, based on theoretical analysis of the squid giant axon AP, has recently been overturned by studies that measured the currents contributing to the AP in several mammalian neurons. In the single compartment models studied here, AP energy consumption varies greatly among vertebrate and invertebrate neurons, with several mammalian neuron models using close to the capacitive minimum of energy needed. Strikingly, energy consumption can increase by more than ten-fold simply by changing the overlap of the Na(+) and K(+) currents during the AP without changing the APs shape. As a consequence, the height and width of the AP are poor predictors of energy consumption. In the Hodgkin-Huxley model of the squid axon, optimizing the kinetics or number of Na(+) and K(+) channels can whittle down the number of ATP molecules needed for each AP by a factor of four. In contrast to the squid AP, the temporal profile of the currents underlying APs of some mammalian neurons are nearly perfectly matched to the optimized properties of ionic conductances so as to minimize the ATP cost.

Improvement of the Shock Absorption Ability of a Face Guard by Incorporating a Glass-Fiber-Reinforced Thermoplastic and Buffering Space

PubMed Central

Churei, Hiroshi; Takayanagi, Haruka; Iwasaki, Naohiko; Takahashi, Hidekazu; Uo, Motohiro

2018-01-01

This study aimed to evaluate the shock absorption ability of trial face guards (FGs) incorporating a glass-fiber-reinforced thermoplastic (GF) and buffering space. The mechanical properties of 3.2 mm and 1.6 mm thick commercial medical splint materials (Aquaplast, AP) and experimental GF prepared from 1.6 mm thick AP and fiberglass cloth were determined by a three-point bending test. Shock absorption tests were conducted on APs with two different thicknesses and two types of experimental materials, both with a bottom material of 1.6 mm thick AP and a buffering space of 30 mm in diameter (APS) and with either (i) 1.6 mm thick AP (AP-APS) or (ii)  1.6 mm thick GF (GF-APS) covering the APS. The GF exhibited significantly higher flexural strength (64.4 MPa) and flexural modulus (7.53 GPa) than the commercial specimens. The maximum load of GF-APS was 75% that of 3.2 mm AP, which is widely used clinically. The maximum stress of the GF-APS only could not be determined as its maximum stress is below the limits of the analysis materials used (<0.5 MPa). Incorporating a GF and buffering space would enhance the shock absorption ability; thus, the shock absorption ability increased while the total thickness and weight decreased. PMID:29854774

Improvement of the Shock Absorption Ability of a Face Guard by Incorporating a Glass-Fiber-Reinforced Thermoplastic and Buffering Space.

PubMed

Wada, Takahiro; Churei, Hiroshi; Takayanagi, Haruka; Iwasaki, Naohiko; Ueno, Toshiaki; Takahashi, Hidekazu; Uo, Motohiro

2018-01-01

This study aimed to evaluate the shock absorption ability of trial face guards (FGs) incorporating a glass-fiber-reinforced thermoplastic (GF) and buffering space. The mechanical properties of 3.2 mm and 1.6 mm thick commercial medical splint materials (Aquaplast, AP) and experimental GF prepared from 1.6 mm thick AP and fiberglass cloth were determined by a three-point bending test. Shock absorption tests were conducted on APs with two different thicknesses and two types of experimental materials, both with a bottom material of 1.6 mm thick AP and a buffering space of 30 mm in diameter (APS) and with either (i) 1.6 mm thick AP (AP-APS) or (ii)  1.6 mm thick GF (GF-APS) covering the APS. The GF exhibited significantly higher flexural strength (64.4 MPa) and flexural modulus (7.53 GPa) than the commercial specimens. The maximum load of GF-APS was 75% that of 3.2 mm AP, which is widely used clinically. The maximum stress of the GF-APS only could not be determined as its maximum stress is below the limits of the analysis materials used (<0.5 MPa). Incorporating a GF and buffering space would enhance the shock absorption ability; thus, the shock absorption ability increased while the total thickness and weight decreased.

Characterization of a diadenosine tetraphosphate-receptor distinct from the ATP-purinoceptor in human tracheal gland cells.

PubMed

Saleh, A; Picher, M; Kammouni, W; Figarella, C; Merten, M D

1999-11-12

Human submucosal tracheal glands are now believed to play a major role in the physiopathology of cystic fibrosis, a genetic disease in which ATP is used as a therapeutic agent. However, actions of ATP on tracheal gland cells are not well known. ATP binds to P2 receptors and induced secretory leucocyte protease inhibitor (SLPI) secretion through formation of cyclic adenosine monophosphate and mobilization of intracellular [Ca(2+)]. Since diadenosine polyphosphates (ApnA) are also endogenous effectors of P2 receptors, we investigated their effects in a cell line (MM39) of human tracheal gland cells. Diadenosine tetraphosphates (Ap4A) induced significant stimulation (+50+/-12%) of SLPI secretion and to a similar extent to that of ATP (+65+/-10%). No significant effects were observed with diadenosine triphosphate (Ap3A), diadenosine pentaphosphate (Ap5A), ADP and 2-methylthio-adenosine triphosphate (2-MeS-ATP). Since Ap4A was weakly hydrolyzed (<2% of total), and the hydrolysis product was only inosine which is ineffective on cells, this Ap4A effect was not due to Ap4A hydrolysis in ATP and adenosine monophosphate (AMP). A mixture of Ap4A and ATP elicited only partial additive effects on SLPI secretion. ADP was shown to be a potent antagonist of ATP and Ap4A receptors, with IC(50)s of 0.8 and 2 microM, respectively. 2-MeS-ATP also showed antagonistic properties with IC(50)s of 20 and 30 microM for ATP- and Ap4A-receptors, respectively. Single cell intracellular calcium ([Ca(2+)](i)) measurements showed similar transient increases of [Ca(2+)](i) after ATP or Ap4A challenges. ATP desensitized the cell [Ca(2+)](i) responses to ATP and Ap4A, and Ap4A also desensitized the cell response to Ap4A. Nevertheless, Ap4A did not desensitize the cell [Ca(2+)](i) responses to ATP. In conclusion, both P2Y2-ATP-receptors and Ap4A-P2D-receptors seem to be present in tracheal gland cells. Ap4A may only bind to P2D-receptors whilst ATP may bind to both Ap4A- and ATP-receptors.

The interaction of diadenosine polyphosphates with P2x-receptors in the guinea-pig isolated vas deferens.

PubMed

Westfall, T D; McIntyre, C A; Obeid, S; Bowes, J; Kennedy, C; Sneddon, P

1997-05-01

1. The site(s) at which diadenosine 5',5"'-P1,P4-tetraphosphate (AP4A) and diadenosine 5', 5"'-P1,P5-pentaphosphate (AP5A) act to evoke contraction of the guinea-pig isolated vas deferens was studied by use of a series of P2-receptor antagonists and the ecto-ATPase inhibitor 6-N,N-diethyl-D-beta,gamma-dibromomethyleneATP (ARL 67156). 2. Pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) (300 nM - 30 microM), suramin (3-100 microM) and pyridoxal-5'-phosphate (P-5-P) (3-1000 microM) inhibited contractions evoked by equi-effective concentrations of AP5A (3 microM), AP4A (30 microM) and alpha,beta-methyleneATP (alpha,beta-meATP) (1 microM), in a concentration-dependent manner and abolished them at the highest concentrations used. 3. PPADS was more potent than suramin, which in turn was more potent than P-5-P. PPADS inhibited AP5A, AP4A and alpha,beta-meATP with similar IC50 values. No significant difference was found between IC50 values for suramin against alpha,beta-meATP and AP5A or alpha,beta-meATP and AP4A, but suramin was more than 2.5 times more potent against AP4A than AP5A. P-5-P showed the same pattern of antagonism. 4. Desensitization of the P2xi-receptor by alpha,beta-meATP abolished contractions evoked by AP5A (3 microM) and AP4A (30 microM), but had no effect on those elicited by noradrenaline (100 microM). 5. ARL 67156 (100 microM) reversibly potentiated contractions evoked by AP4A (30 microM) by 61%, but caused a small, significant decrease in the mean response to AP5A (3 microM). 6. It is concluded that AP4A and AP5A act at the P2xi-receptor, or a site similar to the P2xi-receptor, to evoke contraction of the guinea-pig isolated vas deferens. Furthermore, the potency of AP4A, but not AP5A, appears to be inhibited by an ecto-enzyme which is sensitive to ARL 67156.

In vivo levels of diadenosine tetraphosphate and adenosine tetraphospho-guanosine in Physarum polycephalum during the cell cycle and oxidative stress.

PubMed Central

Garrison, P N; Mathis, S A; Barnes, L D

1986-01-01

Cellular levels of diadenosine tetraphosphate (Ap4A) and adenosine tetraphospho-guanosine (Ap4G) were specifically measured during the cell cycle of Physarum polycephalum by a high-pressure liquid chromatographic method. Ap4A was also measured indirectly by a coupled phosphodiesterase-luciferase assay. No cell cycle-specific changes in either Ap4A or Ap4G were detected in experiments involving different methods of assay, different strains of P. polycephalum, or different methods of fixation of macroplasmodia. Our results on Ap4A are in contrast with those reported previously (C. Weinmann-Dorsch, G. Pierron, R. Wick, H. Sauer, and F. Grummt, Exp. Cell Res. 155:171-177, 1984). Weinmann-Dorsch et al. reported an 8- to 30-fold increase in Ap4A in early S phase in P. polycephalum, as measured by the phosphodiesterase-luciferase assay. We also measured levels of Ap4A, Ap4G, and ATP in macroplasmodia treated with 0.1 mM dinitrophenol. Ap4A and Ap4G transiently increased three- to sevenfold after 1 h and then decreased concomitantly with an 80% decrease in the level of ATP after 2 h in the presence of dinitrophenol. These results do not support the hypothesis that Ap4A is a positive pleiotypic activator that modulates DNA replication, but they are consistent with the hypothesis proposed for procaryotes that Ap4A and Ap4G are signal nucleotides or alarmones of oxidative stress (B.R. Bochner, P.C. Lee, S.W. Wilson, C.W. Cutler, and B.N. Ames, Cell 37:225-232, 1984). PMID:3785160

LaAP2L1, a heterosis-associated AP2/EREBP transcription factor of Larix, increases organ size and final biomass by affecting cell proliferation in Arabidopsis.

PubMed

Li, Ai; Zhou, Yanan; Jin, Chuan; Song, Wenqin; Chen, Chengbin; Wang, Chunguo

2013-11-01

In Larix and in some crops, heterosis is prevalent and has been widely used in breeding to produce excellent varieties. However, the molecular basis of heterosis in Larix remains ambiguous. LaAP2L1, a member of the AP2/EREBP transcription factor family, has been suggested to be involved in heterosis in Larix hybrids. Here, the function and regulation of LaAP2L1 were further explored. Overexpression of LaAP2L1 led to markedly enlarged organs and heterosis-like traits in Arabidopsis. Fresh weight of leaves was almost twice as great as in vector controls. Likewise, seed yield of 35S::LaAP2L1 individual plants was >200% greater than that of control plants. The enlarged organs and heterosis-like traits displayed by 35S::LaAP2L1 plants were mainly due to enhanced cell proliferation and prolonged growth duration. At the molecular level, LaAP2L1 upregulated the expression of ANT, EBP1, and CycD3;1 and inhibited the expression of ARGOS in 35S::LaAP2L1 plants, suggesting an important molecular role of LaAP2L1 in regulating plant organ development. These findings provide new insights into the formation of heterosis in woody plants and suggest that LaAP2L1 has potential applications in breeding high-yielding crops and energy plants. In addition, 50 AP2/EREBP transcription factors, including LaAP2L1, in Larix were identified by transcriptome sequencing, and phylogenetic analysis was conducted. This provided information that will be important in further revealing the functions of these transcription factors.

AFRICAN ABORIGINAL THERAPY

PubMed Central

Sheppard, Philip A. E.

1920-01-01

No other man in America has so complete a knowledge of the aborigines of South Africa as Dr. Sheppard. For twenty-one years he spent his vacations in their kraals. He is a blood-brother in two tribes, and a chief, and sits on his own mat at tribal councils. His picture of their aboriginal therapy is unique. Imagesp228-ap228-bp229-ap229-bp231-ap232-ap232-bp233-ap235-ap235-b PMID:18010265

Molecular Basis for Enhancement of the Meiotic DMCI Recombinase by RAD51AP1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dray, Eloise; Dunlop, Myun Hwa; Kauppi, Liisa

Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor suppression. RAD51AP1 (RAD51 Associated Protein 1) has been shown to interact with and enhance the recombinase activity of RAD51. Accordingly, genetic ablation of RAD51AP1 leads to enhanced sensitivity to and also chromosome aberrations upon DNA damage, demonstrating a role for RAD51AP1 in mitotic homologous recombination. Here we show physical association of RAD51AP1 with the meiosis-specific recombinase DMC1 and a stimulatory effect of RAD51AP1 on the DMC1-mediated D-loop reaction. Mechanistic studies have revealed that RAD51AP1 enhances the ability of the DMC1 presynaptic filament to capture the duplex DNA partnermore » and to assemble the synaptic complex, in which the recombining DNA strands are homologously aligned. We also provide evidence that functional co-operation is dependent on complex formation between DMC1 and RAD51AP1, and that distinct epitopes in RAD51AP1 mediate interactions with RAD51 and DMC1. Finally, we show that RAD51AP1 is expressed in mouse testes, and that RAD51AP1 foci co-localize with a subset of DMC1 foci in spermatocytes. These results suggest that RAD51AP1 also serves an important role in meiotic homologous recombination.« less

An aspartic proteinase gene family in the filamentous fungus Botrytis cinerea contains members with novel features.

PubMed

ten Have, Arjen; Dekkers, Ester; Kay, John; Phylip, Lowri H; van Kan, Jan A L

2004-07-01

Botrytis cinerea, an important fungal plant pathogen, secretes aspartic proteinase (AP) activity in axenic cultures. No cysteine, serine or metalloproteinase activity could be detected. Proteinase activity was higher in culture medium containing BSA or wheat germ extract, as compared to minimal medium. A proportion of the enzyme activity remained in the extracellular glucan sheath. AP was also the only type of proteinase activity in fluid obtained from B. cinerea-infected tissue of apple, pepper, tomato and zucchini. Five B. cinerea genes encoding an AP were cloned and denoted Bcap1-5. Features of the encoded proteins are discussed. BcAP1, especially, has novel characteristics. A phylogenetic analysis was performed comprising sequences originating from different kingdoms. BcAP1 and BcAP5 did not cluster in a bootstrap-supported clade. BcAP2 clusters with vacuolar APs. BcAP3 and BcAP4 cluster with secreted APs in a clade that also contains glycosylphosphatidylinositol-anchored proteinases from Saccharomyces cerevisiae and Candida albicans. All five Bcap genes are expressed in liquid cultures. Transcript levels of Bcap1, Bcap2, Bcap3 and Bcap4 are subject to glucose and peptone repression. Transcripts from all five Bcap genes were detected in infected plant tissue, indicating that at least part of the AP activity in planta originates from the pathogen.

The Effects of Different Purifying Methods on the Chemical Properties, in Vitro Anti-Tumor and Immunomodulatory Activities of Abrus cantoniensis Polysaccharide Fractions

PubMed Central

Wu, Shaowei; Fu, Xiong; Brennan, Margaret A.; Brennan, Charles S.; Chun, Chen

2016-01-01

Abrus cantoniensis (Hance) is a popular Chinese vegetable consumed as a beverage, soup or folk medicine. To fully exploit the potential of the polysaccharide in Abrus cantoniensis, nine polysaccharide fractions of Abrus cantoniensis were isolated and purified (AP-AOH30-1, AP-AOH30-2, AP-AOH80-1, AP-AOH80-2, AP-ACl-1, AP-ACl-2, AP-ACl-3, AP-H and AP-L). Fourier-transform infrared spectroscopy (FT-IR) and gas chromatography (GC) were used to characterize these Abrus polysaccharides fractions (APF). In vitro anti-tumor and immunomodulatory activities were also investigated and compared using the rank-sum ratio (RSR) method. Results demonstrated significant differences in the structure and bioactivities among APF, which were associated to the process used for their purification. Among the APF, AP-ACl-3 yield was 613.5 mg/kg of product and consisted of rhamnose (9.8%), arabinose (8.9%), fructose (3.0%), galactose (9.9%), glucose (4.3%), galacturonic acid (3.0%) and glucuronic acid (61.1%) with a molecular weight of 4.4 × 104 Da. Furthermore, AP-ACl-3 exhibited considerable bioactivities significantly preventing the migration of MCF-7 cells and stimulating lymphocyte proliferation along with nitric oxide (NO) production of peritoneal macrophages. AP-ACl-3 could be explored as a novel potential anti-tumor and immunomodulatory agent. PMID:27058538

A population-based study of severity in patients with acute on chronic pancreatitis.

PubMed

Akshintala, Venkata S; Hutfless, Susan M; Yadav, Dhiraj; Khashab, Mouen A; Lennon, Anne Marie; Makary, Martin A; Hirose, Kenzo; Andersen, Dana K; Kalloo, Anthony N; Singh, Vikesh K

2013-11-01

The objectives of this study were to evaluate the severity of patients with acute pancreatitis (AP) on chronic pancreatitis (CP) and compare this to patients with AP without CP. The Maryland Health Services database was queried for all adult inpatient discharges with a primary diagnosis of AP from 1994 to 2010. Acute pancreatitis on CP and AP without CP were defined by the presence of the associated diagnosis code for CP. Severity was defined as organ failure, intensive care unit stay, or mortality. Acute pancreatitis on CP accounted for 13.7% of all AP discharges (9747/70,944). The proportion of AP-on-CP discharges doubled during the study period (8.8% to 17.6%; P < 0.0001). When compared with patients with AP without CP, AP-on-CP patients were younger, were more likely to be male and black, had higher rates of alcohol and drug abuse, and had less severe disease with lower rates of mortality, organ failure, need for mechanical ventilation, and intensive care unit stay. Among AP-on-CP patients, significant predictors of severity included advanced age, weight loss, and 2 or more comorbidities. Patients with AP on CP have less severe disease than do those with AP without CP. Weight loss, advanced age, and comorbidity increase the risk of severity in patients with AP on CP.

Relation of Angina Pectoris to Outcomes, Quality of Life and Response to Exercise Training in Patients with Chronic Heart Failure (from HF-ACTION)

PubMed Central

Parikh, Kishan S.; Coles, Adrian; Schulte, Phillip J.; Kraus, William E.; Fleg, Jerome L.; Keteyian, Steven J.; Piña, Ileana L.; Fiuzat, Mona; Whellan, David J.; O’Connor, Christopher M.; Mentz, Robert J.

2016-01-01

Angina pectoris (AP) is associated with worse outcomes in heart failure (HF). We investigated the association of AP with health-related quality of life (HRQoL), exercise capacity, and clinical outcomes, and its interaction with exercise training in a HF population. We grouped 2,331 HF patients with reduced ejection fraction (EF) in the HF-ACTION trial of usual care +/− exercise training according to whether they had self-reported AP by Canadian classification score (CCS). HRQoL and clinical outcomes were assessed by AP status. In HF-ACTION, 406 (17%) patients had AP at baseline (44% with CCS ≥ II) with HF severity similar to those without AP. Patients with AP had similar baseline exercise capacity but worse depressive symptoms and HRQoL. AP was associated with 22% greater adjusted risk for all-cause mortality/hospitalizations, driven by hospitalizations. There was significant interaction between baseline AP and exercise training peak VO2 change (P=0.019), but not other endpoints. Exercise training was associated with greater peak VO2 improvement after 3 months in patients with AP (treatment effect=1.25 mL/kg/min, 95% CI=0.6–1.9). In conclusion, AP was associated with worse HRQoL and depressive symptoms. Despite greater peak VO2 improvement with exercise training, patients with AP experienced more adverse outcomes. PMID:27561194

All-Cause and Acute Pancreatitis Health Care Costs in Patients With Severe Hypertriglyceridemia.

PubMed

Rashid, Nazia; Sharma, Puza P; Scott, Ronald D; Lin, Kathy J; Toth, Peter P

2017-01-01

The aim of this study was to assess health care utilization and costs related to acute pancreatitis (AP) in patients with severe hypertriglyceridemia (sHTG) levels. Patients with sHTG levels 1000 mg/dL or higher were identified from January 1, 2007, to June 30, 2013. The first identified incident triglyceride level was labeled as index date. All-cause, AP-related health care visits, and mean total all-cause costs in patients with and without AP were compared during 12 months postindex. A generalized linear model regression was used to compare costs while controlling for patient characteristics and comorbidities. Five thousand five hundred fifty sHTG patients were identified, and 5.4% of these patients developed AP during postindex. Patients with AP had significantly (P < 0.05) more all-cause outpatient visits, hospitalizations, longer length of stays during the hospital visits, and emergency department visits versus patients without AP. Mean (SD) unadjusted all-cause health care costs in the 12 months postindex were $25,343 ($33,139) for patients with AP compared with $15,195 ($24,040) for patients with no AP. The regression showed annual all-cause costs were 49.9% higher (P < 0.01) for patients with AP versus without AP. Patients who developed AP were associated with higher costs; managing patients with sHTG at risk of developing AP may help reduce unnecessary costs.

77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... DEPARTMENT OF EDUCATION Application for New Awards; Advanced Placement (AP) Test Fee Program--Reopening the AP Test Fee Fiscal Year 2012 Competition AGENCY: Office of Elementary and Secondary Education (OESE), Department of Education. ACTION: Notice reopening the AP Test Fee fiscal year 2012 competition...

OXIDATIVE STRESS AND TREG DEPLETION IN LUPUS PATIENTS WITH ANTI-PHOSPHOLIPID SYNDROME

PubMed Central

Lai, Zhi-wei; Marchena-Mendez, Ivan; Perl, Andras

2015-01-01

Anti-phospholipid antibodies (APLA) represent a diagnostic criterion of systemic lupus erythematosus (SLE) and cause morbidity, termed anti-phospholipid syndrome (APS). Activation of the mechanistic target of rapamycin (mTOR) has been recently associated with APS. mTOR is a sensor of oxidative stress. Therefore, we examined mitochondrial mass, superoxide production, mTOR and FoxP3 expression in 72 SLE patients, twelve of whom also had APS, and 54 healthy controls by flow cytometry. Mitochondrial mass was increased in CD4−CD8− double-negative (DN) T cells of SLE patients with APS (2.7-fold) in comparison to those without APS (1.7-fold; p=0.014). Superoxide production was increased in all lymphocyte subsets of APS patients. FoxP3+ cells were depleted within CD4+CD25+ Tregs in patients with APS (28.4%) relative to those without APS (46.3%, p=0.008). mTOR activity was similar between SLE patients with and without APS. Thus, oxidative stress and Treg depletion rather than mTOR activation underlie APS in patients with SLE. PMID:25862984

Molecular and electronic structure of octahedral o-aminophenolato and o-iminobenzosemiquinonato complexes of V(V), Cr(III), Fe(III), and Co(III). Experimental determination of oxidation levels of ligands and metal ions.

PubMed

Chun, H; Verani, C N; Chaudhuri, P; Bothe, E; Bill, E; Weyhermüller, T; Wieghardt, K

2001-08-13

The coordination chemistry of the ligands 2-anilino-4,6-di-tert-butylphenol, H[L(AP)], and N,N"'-bis[2-(4,6-di-tert-butylphenol]diethylenetriamine, H(2)[(L(AP))N(L(AP))], has been studied with the first-row transition metal ions V, Cr, Fe, and Co. The ligands are noninnocent in the sense that the aminophenolato parts, [L(AP)](-) and [L(AP)-H](2)(-), can be readily oxidized to their o-iminobenzosemiquinonato, [L(ISQ)](-), and o-iminobenzoquinone, [L(ISB)], forms. The following neutral octahedral complexes have been isolated as crystalline materials, and their crystal structures have been determined by X-ray crystallography at 100 K: [Cr(III)(L(ISQ))(3)] (1), [Fe(III)(L(ISQ))(3)] (2), [Co(III)(L(ISQ))(3)] (3), [V(V)(L(ISQ))(L(AP)-H)(2)] (4), [V(V)(L(AP)-H)(2)(L(AP))] (5), and [V(V)O[(L(AP))N(L(AP)-H)

A Response to Robert Maranto's Review of "Bad Students, Not Bad Schools"

ERIC Educational Resources Information Center

Weissberg, Robert

2012-01-01

This article presents the author's response to Robert Maranto's review of "Bad Students, Not Bad Schools". The author begins by thanking Professor Maranto for his thoughtful review of his "Bad Students, Not Bad Schools" (2010). Professor Maranto is the first professional educator to acknowledge the book's existence, a fact that says much about…

An Evolutionary Approach to the Biological Management of Invasive Brown Treesnakes (Boiga irregularis) on Guam

DTIC Science & Technology

2012-03-14

only two snake species on the Guam, the other of which is a burrowing blind snake Ramphotyphlops braminus (possibly introduced as well), and none of...descriptions of three new species. Systematic Parasitology 1:127-140. Roberts, L. S. and J. J. Janovy. 2005. Gerald D. Schmidt and Larry S. Roberts

In the Eye of the Library: Poets at the Library of Congress.

ERIC Educational Resources Information Center

D'Ooge, Craig

1998-01-01

Chronicles the evolution of the position of consultant in poetry (in 1989, officially titled Poet Laureate Consultant in Poetry) at the Library of Congress from the 1930s to the present. Poets highlighted include Howard Nemerov, Alan Tate, Robert Penn Warren, Robert Hayden, Joseph Brodsky, Rita Dove, and Stanley Kunitz. A sidebar discusses…

The Education of Nations: An Analysis of Robert B. Reich's Economic Theory.

ERIC Educational Resources Information Center

Lockwood, John H.

This essay critiques the book "The Work of Nations: Preparing Ourselves for 21st Century Capitalism" (1991), by Robert Reich, Secretary of Labor in the Clinton administration. Reich described the development of the symbolic-analyst as the new citizen in the economic order, utilizing the basic skills of abstraction, system thinking,…

Great Mentors: Robert Jervis, Bruce Bueno de Mesquita, and Peter Katzenstein

ERIC Educational Resources Information Center

McDermott, Rose

2010-01-01

I have been extremely blessed in my life to have benefitted from some amazing mentors and friends in both psychology (most notably, Amos Tversky, Phil Zimbardo, and Leda Cosmides) and political science. Inspired by the occasion of Robert Jervis' festschrift, which importantly does not signal his imminent retirement, I was prompted to take…

Dynamics of Interagency Cooperation Process at Provincial Reconstruction Team in Operations ISAF and Enduring Freedom

DTIC Science & Technology

2010-06-11

Carlisle, PA, 2007. Lovelace Jr, Douglas C., Richard A Chilcoat, Jay W Boggs, Dennis C Jett, John F Troxell, H Allen Irish, Joseph J Collins, Carlos...Hernandorena, Katherine Rogers, 102 Patrick B Baetjer, James J Wirtz, Scott R Feil, Robert B Polk, Amanda Smith, Robert H Dorff, James M Smith, Brian

Robert Wartenberg, MD (1887-1956).

PubMed

Pearce, John M S

2018-01-01

Modern technologies have, to some degree, replaced the careful elicitation of neurological physical signs. Many 20th century texts and monographs were devoted to such clinical phenomena. Foremost among them were the assiduous writings of Robert Wartenberg who fled Hitler to enhance Neurology in San Francisco. His work and influences are outlined here. © 2018 S. Karger AG, Basel.

Dr. Robert Goddard

NASA Image and Video Library

2010-01-04

Robert Goddard with a rocket in his workshop at Roswell, NM. October 1935. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

Student Teaching Changed Me: A Look at Kolb's Learning Style Inventory Scores before and after the Student Teaching Experience

ERIC Educational Resources Information Center

Smith, Kasee L.; Rayfield, John

2017-01-01

Student teaching as the culminating experience of a teacher preparation program has been shown to be of great importance in the preparation of pre-service agricultural educators (Harlin, Roberts, Mowen, Edgar, & Briers, 2007; Roberts, Mowen, Edgar, Harlin, & Briers, 2007; Kitchel & Torres, 2006, 2007; Myers & Dyer, 2004). Kolb's…

Robert M. Gagne's Impact on Instructional Design Theory and Practice of the Future.

ERIC Educational Resources Information Center

Richey, Rita C.

Robert Gagne has been a central figure in the infusion of instructional psychology into the field of instructional technology, and in the creation of the domain of instructional design. Gagne's design principles provide not only a theoretical orientation to an instructional design project, but also have prompted a number of design conventions and…

U.S. Foreign Policy’s Role in Homeland Security: The Egyptian Case

DTIC Science & Technology

2011-12-01

Robert E. Looney THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this...CONTENTS I . INTRODUCTION........................................................................................................1 A. MAJOR RESEARCH...PAGE INTENTIONALLY LEFT BLANK xi ACKNOWLEDGMENTS I would like to thank Dr. Abbas Kadhim and Dr. Robert Looney for their support, expertise, and

Welcoming the Sunlight: A Conversation with Mary Kay Zabel and Robert Zabel

ERIC Educational Resources Information Center

Teagarden, James; Kaff, Marilyn

2018-01-01

Professors Emeriti Mary Kay and Robert Zabel share their reflections on their long and productive careers working with students and teachers. Their respective careers share much of the same history and complement each other. The Zabels share their advice with those entering the field and the challenges they see for the education of students with…

Doctor Julius Robert Mayer and Energy Processes in Living Systems

ERIC Educational Resources Information Center

Erlichson, Herman

2007-01-01

The overwhelming majority of important papers in physics are written by physicists. But the physician Julius Robert Mayer (1814-1878, see photo) did a valid theoretical calculation of the mechanical equivalent of heat just before Joule reported on his results from his well-known paddle-wheel experiments. Joule is well-known to physics people and…

Seeking the Balance Between Government and Industry Interests in Software Acquisitions. Volume 1. A Basis for Reconciling DoD and Industry Needs for Rights in Software

DTIC Science & Technology

1987-06-01

Facilitator Robert Voss, Esq. Private Consultant, Honeywell, Inc. Institute for Defense Analyses Robert Adams , Esq. Naval Training Systems Center Mr...Systems Command Leonard Rawlcz, Esq. Skadden, Arps, Slate, Meagher & Flom Ansel Schwartz, Esq. Reed Smith Shaw & McClay Michael Yatsko, Esq

Securing the Aviation Transportation System

DTIC Science & Technology

2007-12-01

accessed 27 May 2007) 13 Robert W. Poole, Jr., “ Airport Security : Time for a New Model,” Reason Foundation online article, January 2006, Available from...15 Robert W. Poole, Jr., “ Airport Security : Time for a New Model,” Reason Foundation online article, January 2006...commercial jetliners. 24 Peter St. John, Air Piracy, Airport Security , and International Terrorism

76 FR 61740 - Geneon Entertainment (USA) Including On-Site Leased Workers From Interplace, Inc., Apple One and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

...) Including On-Site Leased Workers From Interplace, Inc., Apple One and Robert Half Legal Santa Monica, CA...-site leased workers from Interplace, Inc., and Apple One, Santa Monica, California. The workers are... from Interplace, Inc., Apple One and Robert Half Legal, Santa Monica, California, who became totally or...

Lessons in the Conversation That We Are: Robert Frost's "Death of the Hired Man."

ERIC Educational Resources Information Center

Jost, Walter

1996-01-01

Looks at Robert Frost's "The Death of the Hired Man" as a "representative anecdote" for Frost's work, which, taken as a whole, shows readers how to lose themselves among the overlooked places and turnings, the topics and tropes, that make up Frost's rhetorical home, the place of everyday human talk and gossip. (TB)

Robert Sabuda and Matthew Reinhart: A Cut Above

ERIC Educational Resources Information Center

Patton, Jessica Rae

2006-01-01

No one could argue the appeal for kids and adults alike of pop-up books. This article features two pop-up book author-artists, Robert Sabuda and Matthew Reinhart, whose books are in a league apart, with their stunning production values, well-written narratives, informative content and the sheer sophistication of the movable art. The two pioneered…

Our Western Heritage: An Interview with Robert George

ERIC Educational Resources Information Center

Iannone, Carol

2012-01-01

This article presents an interview with Robert George, who holds Princeton's celebrated McCormick Chair in Jurisprudence and is the founding director of the James Madison Program. George has served on the President's Council on Bioethics and as a presidential appointee to the United States Commission on Civil Rights. He is also a member of the…

Robert Bostrom's Contribution to Listening in Organizational Contexts

ERIC Educational Resources Information Center

Brownell, Judi

2013-01-01

Robert Bostrom has not only left a listening legacy, but he was also a pioneer in the larger discipline of communication. Bostrom was one of the first scholars to focus on the dynamics of interpersonal contexts, thereby directly contributing to the transition of our field from "speech" to "communication." Early on he recognized the importance of…

Studies Presented to Robert B. Lees by His Students. Papers in Linguistics.

ERIC Educational Resources Information Center

Sadock, Jerrold M.; Vanek, Anthony L.

This volume, dedicated to Professor Robert B. Lees on the occasion of his departure from the University of Illinois, contains 15 papers on a variety of linguistic topics: C. L. Baker, "Problems of Polarity in Counterfactuals"; Lawrence F. Bouton, "Do So: Do+Adverb"; Chin-chuan Cheng, "Domains of Phonological Rule Application"; Joseph F. Foster,…

The Robert Wood Johnson Foundation Annual Report 1978, January 1, 1978 through December 31, 1978.

ERIC Educational Resources Information Center

Robert Wood Johnson Foundation, New Brunswick, NJ.

The nationwide program of financial aid for students enrolled in medicine and osteopathy, sponsored by the Robert Wood Johnson Foundation, is evaluated. The foundation made scholarship and loan funds available to students with minority backgrounds, to women students, and to students from rural areas. The evaluation study sought to determine…

MSFC Annual Day of Remembrance ceremony

NASA Image and Video Library

2018-01-25

Participants in Marshall Space Flight Center’s annual “Day of Remembrance are, from left to right, MSFC Director Todd May, retired astronaut Jan Davis, retired astronaut Robert “Hoot” Gibson, retired astronaut Robert Stewart, MSFC Deputy Director Jody singer, and Director of Safety and Mission Assurance Rick Burt.

Robert Maynard Hutchins: A Memoir.

ERIC Educational Resources Information Center

Mayer, Milton

This biography reviews the life of Robert Maynard Hutchins, a leader in higher education in the 20th century, by a long-time friend and colleague. The biography first follows Hutchins' story from his origins as a preacher's son in rural Ohio to Oberlin College, through early success at the Yale Law school where he reformed legal education and…

Dr. Robert Goddard

NASA Image and Video Library

2010-01-04

Dr. Robert Goddard's rocket nose cone, parachute, and relase device, April 19, 1935. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

Dr. Robert Goddard

NASA Image and Video Library

2010-01-04

Dr. Robert Goddard with batteries and relay at the launch tower, May 19, 1937. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

Probing the Human Brain with Stimulating Electrodes: The Story of Roberts Bartholow's (1874) Experiment on Mary Rafferty

ERIC Educational Resources Information Center

Harris, Lauren Julius; Almerigi, Jason B.

2009-01-01

Roberts Bartholow's 1874 experiment on Mary Rafferty is widely cited as the first demonstration, by direct application of stimulating electrodes, of the motor excitability of the human cerebral cortex. The many accounts of the experiment, however, leave certain questions and details unexamined or unresolved, especially about Bartholow's goals, the…

75 FR 82003 - Environmental Management Site-Specific Advisory Board, Northern New Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

..., 2010 Meeting Minutes. 1:30 p.m. Public Comment Period. 1:45 p.m. Old Business. Written Reports. Other Items. 2 p.m. New Business. Report on Long-Term Surveillance Conference, Robert Gallegos and Robert... telephone number listed above. Written statements may be filed with the Board either before or after the...

Robert Merton Dies at 92

ERIC Educational Resources Information Center

Snell, Joel C.

2006-01-01

This article features Robert Merton, who died recently at age 92. Merton came into this world as a Jewish baby named Meyer Schkolnick. He lived in South Philly where his parents wrenched a living as blue-collar workers. Merton chose an Anglicized name to move into the Yankee dominated America of the 20's and 30's. At Harvard, he studied under…

Expedition 43 flight control team with Flight Director Gary Horlacher during the release of SpaceX Dragon cargo vehicle. Photo Date: May 21, 2015. Location: Building 30 - FCR1. Photographer: Robert Markowitz

NASA Image and Video Library

2015-05-21

Expedition 43 flight control team with Flight Director Gary Horlacher during the release of SpaceX Dragon cargo vehicle. Photo Date: May 21, 2015. Location: Building 30 - FCR1. Photographer: Robert Markowitz

A Taxonomy for Insourcing in the Aerospace Industry

DTIC Science & Technology

2011-06-01

Patterson Air Force Base, Ohio APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. The...editor (2008) DAU Acquipedia (2011) US Code Title 10 (2011) Robert M. Morgan and Shelby Hunt (1994) Miller and Whitford (2006) Harris and Raviv...G. Bennett (1991) Lambert, Douglas M. editor (2008) DAU Acquipedia (2011) US Code Title 10 (2011) Robert M. Morgan and Shelby Hunt (1994

MAGTF’s for NEF’s: Revolutionary Adaptive Force Packaging or Getting by with Less

DTIC Science & Technology

1994-02-08

13. 14 Ibid., p. 2. 15. Captain Robert 0. Crawshaw , USN, "What is a Maritime Action Group?" U. S. Naval Institute Proceedings, January 1993. p. 28. 1...Amphibious Force Mediterranean" Headquarters, U. S. Marine Corps, Information Paper, November 1993. Crawshaw , Captain Robert 0., USN, "What is a