Utility of NIST Whole-Genome Reference Materials for the Technical Validation of a Multigene Next-Generation Sequencing Test.

PubMed

Shum, Bennett O V; Henner, Ilya; Belluoccio, Daniele; Hinchcliffe, Marcus J

2017-07-01

The sensitivity and specificity of next-generation sequencing laboratory developed tests (LDTs) are typically determined by an analyte-specific approach. Analyte-specific validations use disease-specific controls to assess an LDT's ability to detect known pathogenic variants. Alternatively, a methods-based approach can be used for LDT technical validations. Methods-focused validations do not use disease-specific controls but use benchmark reference DNA that contains known variants (benign, variants of unknown significance, and pathogenic) to assess variant calling accuracy of a next-generation sequencing workflow. Recently, four whole-genome reference materials (RMs) from the National Institute of Standards and Technology (NIST) were released to standardize methods-based validations of next-generation sequencing panels across laboratories. We provide a practical method for using NIST RMs to validate multigene panels. We analyzed the utility of RMs in validating a novel newborn screening test that targets 70 genes, called NEO1. Despite the NIST RM variant truth set originating from multiple sequencing platforms, replicates, and library types, we discovered a 5.2% false-negative variant detection rate in the RM truth set genes that were assessed in our validation. We developed a strategy using complementary non-RM controls to demonstrate 99.6% sensitivity of the NEO1 test in detecting variants. Our findings have implications for laboratories or proficiency testing organizations using whole-genome NIST RMs for testing. Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

10 CFR 431.105 - Materials incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AND INDUSTRIAL EQUIPMENT Commercial Water Heaters, Hot Water Supply Boilers and Unfired Hot Water... Water Supply Boilers, and Unfired Hot Water Storage Tanks,” Docket No. EE-RM/TP-99-480, Forrestal... Water Heaters, Volume III, Storage Water Heaters with Input Ratings above 75,000 Btu per Hour...

Probing the Electronic Structure of - and Electron-Doped High-Temperature Superconductors with Photoemission and X-Ray Absorption Spectroscopies

NASA Astrophysics Data System (ADS)

Lederman, Eli R.

1990-01-01

The electronic structures of hole- and electron -doped high temperature superconductors have been probed using x-ray absorption near-edge spectroscopy (XANES) and photoelectron emission spectroscopy (PES). These measurements have been performed on RBa_2Cu _3O_{rm 7-y} , La_{rm 2-x}Sr _{rm x}CuO _4 and Ln_{rm 2 -x}Ce_{rm x} CuO_{rm 4} for R = Y, Eu and Ln = Nd, Pr and Sm. The parameters x and y have been varied to include a range of hole and electron carrier densities and the undoped parent compounds. Previous XANES and PES results have indicated that unoccupied states of O 2p character can be associated with the carriers in the materials RBa_2 Cu_3O_{ rm 7-y} and La_{ rm 2-x}Sr_{rm x}CuO_4 and that the density of holes increases with O and Sr content, respectively. Conduction was hole-based in all known high-T_{ rm c} cuprates until the recent discovery of superconductivity in Ln_{rm 2-x}Ce_{rm x} CuO_4. Hall coefficient measurements have suggested that the carriers in this system are electrons added with Ce doping. It has been anticipated that these electron-doped materials will provide an important test for models of high temperature superconductivity. PES measurements are presented that show significant Cu 3d character in the valence band of these electron-based materials, but that the Cu^{2+} /Cu^{1+} ratio is unchanged by the level of Ce doping, indicating that doped electrons are itinerant rather than highly correlated. Resonant photoemission from the valence band indicates the presence of unoccupied O 2p states, but these holes are less abundant than in the hole-doped materials. Measurements of XANES at the O 1s edge suggest that unoccupied states of O 2p character in the electron -doped materials are not related to conduction in a simple way. The density of these holes is shown to decrease upon Ce doping and the process of reduction, despite the fact that both are necessary of superconductivity. Furthermore, whereas the O 2p holes are at E_{rm F} in the hole-doped materials, they are ~1 eV above E_{ rm F} in their electron-doped counterparts. A schematic of the band structure is proposed on the basis of these spectroscopic measurements.

On the isolation of elemental carbon (EC) for micro-molar 14C accelerator mass spectrometry: development of a hybrid reference material for 14C-EC accuracy assurance, and a critical evaluation of the thermal optical kinetic (TOK) EC isolation procedure

NASA Astrophysics Data System (ADS)

Currie, L. A.; Kessler, J. D.

2005-10-01

The primary objective of the research reported here has been the development of a hybrid reference material (RM) to serve as a test of accuracy for elemental carbon (EC) isotopic (14C) speciation measurements. Such measurements are vital for the quantitative apportionment of fossil and biomass sources of "soot" (EC), the tracer of fire that has profound effects on health, atmospheric visibility, and climate. Previous studies of 14C-EC measurement quality, carried out with NIST SRM 1649a (Urban Dust), showed a range of results, but since the "truth" was not known for this natural matrix RM, one had to rely on isotopic-chemical consistency evidence (14C in PAH, EC) of measurement validity (Currie et al., 2002). Components of the new Hybrid RM (DiesApple), however, have known 14C and EC composition, and they are nearly orthogonal (isotopically and chemically). NIST SRM 2975 (Forklift Diesel Soot) has little or no 14C, and its major compositional component is EC; SRM 1515 (Apple Leaves) has the 14C content of biomass-C, and it has little or no EC. Thus, the Hybrid RM can serve as an absolute isotopic test for the absence of EC-mimicking pyrolysis-C (char) from SRM 1515 in the EC isolate of the Hybrid RM, as well as a test for conservation of its dominant soot fraction throughout the isolation procedure.

The secondary objective was to employ the Hybrid RM for the comparative evaluation of the thermal optical kinetic (TOK) and thermal optical transmission (TOT) methods for the isolation of EC for micro-molar carbon accelerator mass spectrometry (AMS). As part of this process, the relatively new TOK method was subjected to a critical evaluation and significant development. Key findings of our study are: (1) both methods exhibited biomass-C "leakage"; for TOT, the EC fraction isolated for AMS contained about 8% of the original biomass-C; for TOK, the refractory carbon (RC) isolated contained about 3% of the original biomass-C.; (2) the initial isothermal oxidation stage of the TOK method substantially reduced the transfer of artifact char to the RC fraction, improving isolation capabilities; (3) the Hybrid RM was not equal to the sum of its parts, with matrix interactions inducing premature loss of EC which, however, could be quantified and minimized; (4) the three-stage TOK method provided a superior capability for carbonate quantification at the sub-micromolar level, with "reagent-free" removal of carbonate-C from EC - essential for low-level EC-14C AMS.

Feasibility study on production of a matrix reference material for cyanobacterial toxins.

PubMed

Hollingdale, Christie; Thomas, Krista; Lewis, Nancy; Békri, Khalida; McCarron, Pearse; Quilliam, Michael A

2015-07-01

The worldwide increase in cyanobacterial contamination of freshwater lakes and rivers is of great concern as many cyanobacteria produce potent hepatotoxins and neurotoxins (cyanotoxins). Such toxins pose a threat to aquatic ecosystems, livestock, and drinking water supplies. In addition, dietary supplements prepared from cyanobacteria can pose a risk to consumers if they contain toxins. Analytical monitoring for toxins in the environment and in consumer products is essential for the protection of public health. Reference materials (RMs) are an essential tool for the development and validation of analytical methods and are necessary for ongoing quality control of monitoring operations. Since the availability of appropriate RMs for cyanotoxins has been very limited, the present study was undertaken to examine the feasibility of producing a cyanobacterial matrix RM containing various cyanotoxins. The first step was large-scale culturing of various cyanobacterial cultures that produce anatoxins, microcystins, and cylindrospermopsins. After harvesting, the biomass was lyophilized, blended, homogenized, milled, and bottled. The moisture content and physical characteristics were assessed in order to evaluate the effectiveness of the production process. Toxin levels were measured by liquid chromatography with tandem mass spectrometry and ultraviolet detection. The reference material was found to be homogeneous for toxin content. Stability studies showed no significant degradation of target toxins over a period of 310 days at temperatures up to +40 °C except for the anatoxin-a, which showed some degradation at +40 °C. These results show that a fit-for-purpose matrix RM for cyanotoxins can be prepared using the processes and techniques applied in this work.

Inhibition of seedling survival under Rhododendron maximum (Ericaceae): could allelopathy be a cause?

PubMed

Nilsen, E T; Walker, J F; Miller, O K; Semones, S W; Lei, T T; Clinton, B D

1999-11-01

In the southern Appalachian mountains a subcanopy species, Rhododendron maximum, inhibits the establishment and survival of canopy tree seedlings. One of the mechanisms by which seedlings could be inhibited is an allelopathic effect of decomposing litter or leachate from the canopy of R. maximum (R.m.) on seed germination, root elongation, or mycorrhizal colonization. The potential for allelopathy by R.m. was tested with two bioassay species (lettuce and cress), with seeds from four native tree species, and with three ectomycorrhizal fungi. Inhibitory influences of throughfall, fresh litter, and decomposed litter (organic layer) from forest with R.m. (+R.m. sites) were compared to similar extractions made from forest without R.m. (-R.m. sites). Throughfall and leachates of the organic layer from both +R.m. and -R.m. sites stimulated germination of the bioassay species above that of the distilled water control, to a similar extent. There was an inhibitory effect of leachates of litter from +R.m. sites on seed germination and root elongation rate of both bioassay species compared with that of litter from -R.m. sites. Native tree seed stratified in forest floor material from both forest types had a slightly higher seed germination rate compared with the control. A 2-yr study of seed germination and seedling mortality of two tree species, Quercus rubra and Prunus serotina, in field plots showed no significant influence of litter or organic layer from either forest type. Incorporating R.m. leaf material into the growth medium in vitro depressed growth of one ectomycorrhizal species but did not affect two other species. Leaf material from other deciduous tree species depressed ectomycorrhizal growth to a similar or greater extent as leaf material from R.m. In conclusion, R.m. litter can have an allelopathic effect on seed germination and root elongation of bioassay species as well as some ectomycorrhizal species. However, this allelopathic affect is not manifest in field sites and is not likely to be an important cause for the inhibition of seedling survival within thickets of R.m.

CD-SEM real time bias correction using reference metrology based modeling

NASA Astrophysics Data System (ADS)

Ukraintsev, V.; Banke, W.; Zagorodnev, G.; Archie, C.; Rana, N.; Pavlovsky, V.; Smirnov, V.; Briginas, I.; Katnani, A.; Vaid, A.

2018-03-01

Accuracy of patterning impacts yield, IC performance and technology time to market. Accuracy of patterning relies on optical proximity correction (OPC) models built using CD-SEM inputs and intra die critical dimension (CD) control based on CD-SEM. Sub-nanometer measurement uncertainty (MU) of CD-SEM is required for current technologies. Reported design and process related bias variation of CD-SEM is in the range of several nanometers. Reference metrology and numerical modeling are used to correct SEM. Both methods are slow to be used for real time bias correction. We report on real time CD-SEM bias correction using empirical models based on reference metrology (RM) data. Significant amount of currently untapped information (sidewall angle, corner rounding, etc.) is obtainable from SEM waveforms. Using additional RM information provided for specific technology (design rules, materials, processes) CD extraction algorithms can be pre-built and then used in real time for accurate CD extraction from regular CD-SEM images. The art and challenge of SEM modeling is in finding robust correlation between SEM waveform features and bias of CD-SEM as well as in minimizing RM inputs needed to create accurate (within the design and process space) model. The new approach was applied to improve CD-SEM accuracy of 45 nm GATE and 32 nm MET1 OPC 1D models. In both cases MU of the state of the art CD-SEM has been improved by 3x and reduced to a nanometer level. Similar approach can be applied to 2D (end of line, contours, etc.) and 3D (sidewall angle, corner rounding, etc.) cases.

Evaluation of Planning for Fish and Wildlife at Corps of Engineers Reservoirs, Beltzville Reservoir Project, Pennsylvania.

DTIC Science & Technology

1981-04-01

community studies 56 Angler survey 63 Fishery Resources -- Discussion of Planning Input 73 SUMARY 81 BIBLIOGRAPHY OF SOURCE REFERENCE MATERIAL 88 - ii...necessary and Identify by block number) Fishery resources Wildlife resources Planning recommendation Pre-impoundment prediction Planning evaluation Post...impoundment occurrences Beltzville Wildlife communities \\ Pennsylvania Fish communities 20. AISSrRACT (Camtflue rm *r e.fth f nrceweary awd Idertify by

Managing Food Allergens in the U.K. Retail Supply Chain.

PubMed

Walker, Michael J; Gowland, M Hazel; Points, John

2018-01-01

The U.K. food and grocery market is highly significant financially and dominated by 10 retailers within a regulated and extremely economically competitive environment. We summarize the approach of U.K. retailers to allergen risk assessment (RA) and risk management (RM) within the U.K. legal framework and explore public visibility of retailers' allergen policies. RA and RM of allergens appear effective in curtailing retail-triggered severe food allergy reactions. However, allergen recalls remain high, precautionary allergen labeling (PAL) remains an area of confusion, and there is no consistent Web-based provision of information for consumers who have allergies. Resolution of PAL awaits an agreed-on threshold framework, but a key challenge is to engage with patients and gain their trust rather than thrust education at them. It would be helpful for retailers to publish their allergen RA and RM policies. A target should be agreed on between government and retailers for a reduction in the proliferation of PAL wording variants by a given date within the next 3 years. A further hurdle is potentially flawed allergen analysis-development of reference methods and reference materials are acknowledged needs. Laboratories should report allergen results in an informative manner, communicating uncertainty and caveats. Ideally a laboratory representative would be included on any incident control team. Efforts must continue to standardize preparedness for protecting and defending food and drink from deliberate attack.

A reference model for space data system interconnection services

NASA Astrophysics Data System (ADS)

Pietras, John; Theis, Gerhard

1993-03-01

The widespread adoption of standard packet-based data communication protocols and services for spaceflight missions provides the foundation for other standard space data handling services. These space data handling services can be defined as increasingly sophisticated processing of data or information received from lower-level services, using a layering approach made famous in the International Organization for Standardization (ISO) Open System Interconnection Reference Model (OSI-RM). The Space Data System Interconnection Reference Model (SDSI-RM) incorporates the conventions of the OSIRM to provide a framework within which a complete set of space data handling services can be defined. The use of the SDSI-RM is illustrated through its application to data handling services and protocols that have been defined by, or are under consideration by, the Consultative Committee for Space Data Systems (CCSDS).

A reference model for space data system interconnection services

NASA Technical Reports Server (NTRS)

Pietras, John; Theis, Gerhard

1993-01-01

The widespread adoption of standard packet-based data communication protocols and services for spaceflight missions provides the foundation for other standard space data handling services. These space data handling services can be defined as increasingly sophisticated processing of data or information received from lower-level services, using a layering approach made famous in the International Organization for Standardization (ISO) Open System Interconnection Reference Model (OSI-RM). The Space Data System Interconnection Reference Model (SDSI-RM) incorporates the conventions of the OSIRM to provide a framework within which a complete set of space data handling services can be defined. The use of the SDSI-RM is illustrated through its application to data handling services and protocols that have been defined by, or are under consideration by, the Consultative Committee for Space Data Systems (CCSDS).

Genetics Home Reference: chorea-acanthocytosis

MedlinePlus

... Danek A, Rampoldi L, Hardie RJ, Chalmers RM, Wood NW, Bohlega S, Dotti MT, Federico A, Shizuka M, ... Stone C, Rubio JP, Danek A, Chalmers RM, Wood NW, Verellen C, Ferrer X, Malandrini A, Fabrizi ...

RANS Simulation (Rotating Reference Frame Model [RRF]) of Single Lab-Scaled DOE RM1 MHK Turbine

DOE Data Explorer

Javaherchi, Teymour; Stelzenmuller, Nick; Aliseda, Alberto; Seydel, Joseph

2014-04-15

Attached are the .cas and .dat files for the Reynolds Averaged Navier-Stokes (RANS) simulation of a single lab-scaled DOE RM1 turbine implemented in ANSYS FLUENT CFD-package. The lab-scaled DOE RM1 is a re-design geometry, based of the full scale DOE RM1 design, producing same power output as the full scale model, while operating at matched Tip Speed Ratio values at reachable laboratory Reynolds number (see attached paper). In this case study taking advantage of the symmetry of lab-scaled DOE RM1 geometry, only half of the geometry is models using (Single) Rotating Reference Frame model [RRF]. In this model RANS equations, coupled with k-\\omega turbulence closure model, are solved in the rotating reference frame. The actual geometry of the turbine blade is included and the turbulent boundary layer along the blade span is simulated using wall-function approach. The rotation of the blade is modeled by applying periodic boundary condition to sets of plane of symmetry. This case study simulates the performance and flow field in the near and far wake of the device at the desired operating conditions. The results of these simulations were validated against in-house experimental data. Please see the attached paper.

A novel and eco-friendly analytical method for phosphorus and sulfur determination in animal feed.

PubMed

Novo, Diogo L R; Pereira, Rodrigo M; Costa, Vanize C; Hartwig, Carla A; Mesko, Marcia F

2018-04-25

An eco-friendly method for indirect determining phosphorus and sulfur in animal feed by ion chromatography was proposed. Using this method, it was possible to digest 500 mg of animal feed in a microwave system under oxygen pressure (20 bar) using only a diluted acid solution (2 mol L -1 HNO 3 ). The accuracy of the proposed method was evaluated by recovery tests, by analysis of reference material (RM) and by comparison of the results with those obtained using conventional microwave-assisted digestion. Moreover, P results were compared with those obtained from the method recommended by AOAC International for animal feed (Method nr. 965.17) and no significant differences were found between the results. Recoveries for P and S were between 94 and 97%, and agreements with the reference values of RM were better than 94%. Phosphorus and S concentrations in animal feeds ranged from 10,026 to 28,357 mg kg -1 and 2259 to 4601 mg kg -1 , respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effects of Phase Transformations and Dynamic Material Strength on Hydrodynamic Instability Evolution in Metals

NASA Astrophysics Data System (ADS)

Opie, Saul

Hydrodynamic phenomena such as the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities can be described by exponential/linear growth of surface perturbations at a bimaterial interface when subjected to constant/impulsive acceleration. A challenge in designing systems to mitigate or exploit these effects is the lack of accurate material models at large dynamic strain rates and pressures. In particular, little stress-strain constitutive information at large strain rates and pressures is available for transient material phases formed at high pressures, and the continuum effect the phase transformation process has on the instability evolution. In this work, a phase-aware isotropic strength model is developed and partially validated with a novel RM-based instability experiment in addition to existing data from the literature. With the validated material model additional simulations are performed to provide insight into to the role that robust material constitutive behavior (e.g., pressure, temperature, rate dependence) has on RM instability and how RM instability experiments can be used to characterize and validated expected material behavior. For phase aware materials, particularly iron in this work, the simulations predict a strong dependence on the Atwood number that single phase materials do not have. At Atwood numbers close to unity, and pressures in the high pressure stability region, the high pressure phase dominates the RM evolution. However, at Atwood numbers close to negative one, the RM evolution is only weakly affected by the high-pressure phase even for shocks well above the phase transformation threshold. In addition to RM evolution this work looks at the closely related shock front perturbation evolution. Existing analytical models for isentropic processes in gases and liquids are modified for metal equation of states and plastic behavior for the first time. It is found that the presence of a volume collapsing phase transformation with increased pressure causes shock front perturbations to decay sooner, while plastic strength has the opposite effect which is significantly different from the effect viscosity has. These results suggest additional experimental setups to validate material models, or relevant material parameters that can be optimized for system design objectives, e.g., minimize feed through perturbations in inertial confinement fusion capsules.

Do Students Who Get Low Grades Only in Research Methods Need the Same Help as Students Who Get Low Grades in All Topics in Psychology?

ERIC Educational Resources Information Center

Barry, John A.

2012-01-01

Some psychology students achieve high grades in all classes except for research methods (RM). Previous research has usually treated low levels of achievement in RM as a unitary phenomenon, without reference to the grades the student is achieving in other subjects. The present internet survey explored preferences for learning RM in 140 psychology…

Development of the Quality Assurance/Quality Control Procedures for a Neutron Interrogation System

NASA Astrophysics Data System (ADS)

Obhođaš, Jasmina; Sudac, Davorin; Valković, Vladivoj

2016-06-01

In order to perform Quality Assurance/Quality Control (QA/QC) procedures for a system dedicated to the neutron interrogation of objects for the presence of threat materials one needs to perform measurements of reference materials (RM) i.e. simulants having the same (or similar) atomic ratios as real materials. It is well known that explosives, drugs, and various other benign materials, contain chemical elements such as hydrogen, oxygen, carbon and nitrogen in distinctly different quantities. For example, a high carbon-to-oxygen ratio (C/O) is characteristic of drugs. Explosives can be differentiated by measurement of both (C/O) and nitrogen-to-oxygen (N/O) ratios. The C/N ratio of the chemical warfare agents, coupled with the measurement of elements such as fluorine and phosphorus, clearly differentiate them from the conventional explosives. Here we present the RM preparation, calibration procedure and correlations attained between theoretical values and experimentally obtained results in laboratory conditions for C/O and N/C ratios of prepared hexogen (RDX), TNT, DLM2, TATP, cocaine, heroin, yperite, tetranitromethane, peroxide methylethylketone, nitromethane and ethyleneglycol dinitrate simulants. We have shown that analyses of the gamma ray spectra by using simple unfolding model developed for this purpose gave a nice agreement with the chemical formula of created simulants, thus the calibration quality was successfully tested.

Hyperfine structure and isotope shift analysis of singly ionized titanium

NASA Astrophysics Data System (ADS)

Bouazza, Safa

2013-04-01

The even-parity low configuration system of Ti II has been considered on the basis of the experimental data found in the literature, and its fine structure has been reanalyzed by simultaneous parameterization of one- and two-body interactions for the model space (3d + 4s)3. Furthermore, the main one-electron hyperfine structure parameters for these configurations have been evaluated. For instance, for 3d24s1, a_{3{\\rm{d}}}^{01} = - {\\rm{63}}.{\\rm{2}}\\left( {{\\rm{3}}.{\\rm{1}}} \\right)\\,{\\rm{MHz}} and a_{4{\\rm{s}}}^{10} = - {\\rm{984}}.{\\rm{1}}\\left( {{\\rm{7}}.{\\rm{1}}} \\right)\\,{\\rm{MHz}} . Field shifts (FS) and specific mass shifts (SMS) of the main Ti II configurations are deduced by means of ab initio estimates combined with a small quantity of experimental isotope shift data available in the literature: FS(3d3) = -63.3 MHz, FS(3d24p1) = -49.7 MHz, FS(3d14s2) = 98.2 MHz, FS(4s24P1) = 163.4 MHz and SMS(3d3) = 1453.3 MHz, SMS(3d14s2) = -2179.7 MHz, …, referred to 3d24s1 for the pair Ti46-Ti48.

The Command and Control Reference Model for modeling, simulations, and technology applications

NASA Astrophysics Data System (ADS)

Mayk, Israel

1994-01-01

The C2RM provides a framework for the evolution of a coordinated and detailed definition of a command and control (C2) discipline. The C2RM embodies an integrated multidisciplinary approach. It is intended to be complete and self-consistent for the main levels of abstractions encountered in models, simulations, operational applications, functional descriptions, paradigms and metaphors of C2. The scope of the C2RM embraces C2 using all key physical and logical interactions associated with C2 systems. It is concerned with interactions, involving not only communications (e.g., radios), but transportations (e.g., vehicles), identifications (e.g., sensors), and inflictions (e.g., weapons), which take place between resources of the same, friendly, hostile or neutral C2 units. High levels of abstractions of user requirements for C2 across the broad spectrum of military and civil domains have led to the development of the C2RM. It applies to all phases of system acquisition from the laboratory to the field and from conceptualization to realization. The C2RM is based upon generic and analog extensions to the International Standards Organization (ISO) open system interconnection (OSI) reference model (RM) which go far beyond the scope of the ISO OSI RM. The major theme, however, of layering services is preserved to facilitate understanding, reuse of design, implementation, and interoperability to the maximum degree possible with available C2 technology.

76 FR 68810 - Notice of Final Federal Agency Actions on Farm-to-Market 1626 in Texas

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

..., from Ranch-to-Market (RM) 967 to Brodie Lane in Hays and Travis Counties, Texas. Those actions grant... (FM) 1626 from Ranch-to-Market (RM) 967 to Brodie Lane in Hays and Travis Counties; Project Reference...

Extensive sequencing of seven human genomes to characterize benchmark reference materials

PubMed Central

Zook, Justin M.; Catoe, David; McDaniel, Jennifer; Vang, Lindsay; Spies, Noah; Sidow, Arend; Weng, Ziming; Liu, Yuling; Mason, Christopher E.; Alexander, Noah; Henaff, Elizabeth; McIntyre, Alexa B.R.; Chandramohan, Dhruva; Chen, Feng; Jaeger, Erich; Moshrefi, Ali; Pham, Khoa; Stedman, William; Liang, Tiffany; Saghbini, Michael; Dzakula, Zeljko; Hastie, Alex; Cao, Han; Deikus, Gintaras; Schadt, Eric; Sebra, Robert; Bashir, Ali; Truty, Rebecca M.; Chang, Christopher C.; Gulbahce, Natali; Zhao, Keyan; Ghosh, Srinka; Hyland, Fiona; Fu, Yutao; Chaisson, Mark; Xiao, Chunlin; Trow, Jonathan; Sherry, Stephen T.; Zaranek, Alexander W.; Ball, Madeleine; Bobe, Jason; Estep, Preston; Church, George M.; Marks, Patrick; Kyriazopoulou-Panagiotopoulou, Sofia; Zheng, Grace X.Y.; Schnall-Levin, Michael; Ordonez, Heather S.; Mudivarti, Patrice A.; Giorda, Kristina; Sheng, Ying; Rypdal, Karoline Bjarnesdatter; Salit, Marc

2016-01-01

The Genome in a Bottle Consortium, hosted by the National Institute of Standards and Technology (NIST) is creating reference materials and data for human genome sequencing, as well as methods for genome comparison and benchmarking. Here, we describe a large, diverse set of sequencing data for seven human genomes; five are current or candidate NIST Reference Materials. The pilot genome, NA12878, has been released as NIST RM 8398. We also describe data from two Personal Genome Project trios, one of Ashkenazim Jewish ancestry and one of Chinese ancestry. The data come from 12 technologies: BioNano Genomics, Complete Genomics paired-end and LFR, Ion Proton exome, Oxford Nanopore, Pacific Biosciences, SOLiD, 10X Genomics GemCode WGS, and Illumina exome and WGS paired-end, mate-pair, and synthetic long reads. Cell lines, DNA, and data from these individuals are publicly available. Therefore, we expect these data to be useful for revealing novel information about the human genome and improving sequencing technologies, SNP, indel, and structural variant calling, and de novo assembly. PMID:27271295

ccML, a new mark-up language to improve ISO/EN 13606-based electronic health record extracts practical edition

PubMed Central

Sánchez-de-Madariaga, Ricardo; Muñoz, Adolfo; Cáceres, Jesús; Somolinos, Roberto; Pascual, Mario; Martínez, Ignacio; Salvador, Carlos H; Monteagudo, José Luis

2013-01-01

Objective The objective of this paper is to introduce a new language called ccML, designed to provide convenient pragmatic information to applications using the ISO/EN13606 reference model (RM), such as electronic health record (EHR) extracts editors. EHR extracts are presently built using the syntactic and semantic information provided in the RM and constrained by archetypes. The ccML extra information enables the automation of the medico-legal context information edition, which is over 70% of the total in an extract, without modifying the RM information. Materials and Methods ccML is defined using a W3C XML schema file. Valid ccML files complement the RM with additional pragmatics information. The ccML language grammar is defined using formal language theory as a single-type tree grammar. The new language is tested using an EHR extracts editor application as proof-of-concept system. Results Seven ccML PVCodes (predefined value codes) are introduced in this grammar to cope with different realistic EHR edition situations. These seven PVCodes have different interpretation strategies, from direct look up in the ccML file itself, to more complex searches in archetypes or system precomputation. Discussion The possibility to declare generic types in ccML gives rise to ambiguity during interpretation. The criterion used to overcome ambiguity is that specificity should prevail over generality. The opposite would make the individual specific element declarations useless. Conclusion A new mark-up language ccML is introduced that opens up the possibility of providing applications using the ISO/EN13606 RM with the necessary pragmatics information to be practical and realistic. PMID:23019241

21 CFR 109.30 - Tolerances for polychlorinated biphenyls (PCB's).

Code of Federal Regulations, 2010 CFR

2010-04-01

... incorporated by reference. Copies are available from the Division of Dockets Management (HFA-305), Food and... Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852. (d) Any... Division of Dockets Management, Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD...

The effects of attention on age-related relational memory deficits: Evidence from a novel attentional manipulation

PubMed Central

Kim, So-Yeon; Giovanello, Kelly S.

2011-01-01

Healthy aging is often accompanied by episodic memory decline. Prior studies have consistently demonstrated that older adults show disproportionate deficits in relational memory (RM) relative to item memory (IM). Despite rich evidence of an age-related RM deficit, the source of this deficit remains unspecified. One of the most widely investigated factors of age-related RM impairment is a reduction in attentional resources. However, no prior studies have demonstrated that reduced attentional resources are the critical source of age-related RM deficits. Here, we utilized qualitatively different attention tasks, and tested whether reduced attention for relational processing underlies the RM deficit observed in aging. In Experiment 1, we imposed either item-detection or relation-detection attention tasks on young adults during episodic memory encoding, and found that only the concurrent attention task involving relational processing disproportionately impaired RM performance in young adults. Moreover, by ruling out the possible confound of task-difficulty on the disproportionate RM impairment, we further demonstrated that reduced relational attention is a key factor for the age-related RM deficit. In Experiment 2, we replicated the results from Experiment 1 using different materials of stimuli and found that the effect of relational attention on RM is material-general. The results of Experiment 2 also showed that reducing attentional resources for relational processing in young adults strikingly equated their RM performance to that of older adults. Thus, the current study documents the first evidence that reduced attentional resources for relational processing are a critical factor for the relational memory impairment observed in aging. PMID:21707178

Mineralogical Composition of the Different Types of Bright Deposits on Vesta

NASA Technical Reports Server (NTRS)

Zambon, F.; Capaccioni, F.; DeSanctis, M. C.; Ammannito, E.; Li, J.-Y.; Longobardo, A.; Mittlefehldt, D. W.; Palomba, E.; Pieters, C. M.; Schroeder, S. E.;

Effects of protective resin coating on the surface roughness and color stability of resin-based restorative materials.

PubMed

Bagis, Bora; Tüzüner, Tamer; Turgut, Sedanur; Korkmaz, Fatih Mehmet; Baygın, Özgül; Bağış, Yıldırım Hakan

2014-01-01

The aim of this study was to evaluate the effects of nanofilled protective resin coating (RC) on the surface roughness (Ra) and color stability (ΔE) of resin-based restorative materials (RM) (compomer (C), nanofilled composite (NF), and microhybrid composite (MH)) after being submitted to the ultraviolet aging (UV) method. Thirty-six specimens were prepared (n = 6 for each group). The Ra and (ΔE) values and SEM images were obtained before and after UV. Significant interactions were found among the RM-RC-UV procedures for Ra (P < 0.001). After the specimens were submitted to UV, the Ra values were significantly increased, regardless of the RC procedure (with RC; P < 0.01 for all, without RC; C (P < 0.01), NF (P < 0.001), and MH (P < 0.001)) for each RM. Significant interactions were found between the RM-RC (P < 0.001) procedures for the ΔE values. The ΔE values were increased in each group after applying the RC procedures (P < 0.001). Protective RC usage for RM could result in material-related differences in Ra and ΔE as with used UV method.

Effects of Protective Resin Coating on the Surface Roughness and Color Stability of Resin-Based Restorative Materials

PubMed Central

Tüzüner, Tamer; Korkmaz, Fatih Mehmet; Baygın, Özgül; Bağış, Yıldırım Hakan

2014-01-01

The aim of this study was to evaluate the effects of nanofilled protective resin coating (RC) on the surface roughness (Ra) and color stability (ΔE) of resin-based restorative materials (RM) (compomer (C), nanofilled composite (NF), and microhybrid composite (MH)) after being submitted to the ultraviolet aging (UV) method. Thirty-six specimens were prepared (n = 6 for each group). The Ra and (ΔE) values and SEM images were obtained before and after UV. Significant interactions were found among the RM-RC-UV procedures for Ra (P < 0.001). After the specimens were submitted to UV, the Ra values were significantly increased, regardless of the RC procedure (with RC; P < 0.01 for all, without RC; C (P < 0.01), NF (P < 0.001), and MH (P < 0.001)) for each RM. Significant interactions were found between the RM-RC (P < 0.001) procedures for the ΔE values. The ΔE values were increased in each group after applying the RC procedures (P < 0.001). Protective RC usage for RM could result in material-related differences in Ra and ΔE as with used UV method. PMID:25162066

Revertant mosaicism in heritable skin diseases: mechanisms of natural gene therapy.

PubMed

Pasmooij, Anna M G; Jonkman, Marcel F; Uitto, Jouni

2012-09-01

Revertant mosaicism (RM) refers to the co-existence of cells carrying disease-causing mutations with cells in which the inherited mutation is genetically corrected by a spontaneous event. It has been discovered in an increasing number of heritable skin diseases: ichthyosis with confetti and different subtypes of epidermolysis bullosa. This "natural gene therapy" phenomenon manifests as normal appearing skin areas surrounded by affected skin. Although initially thought to be rare, RM is now considered relatively common in genetic skin diseases. To address the issues relevant to RM, we here discuss the following questions: 1) What is the incidence of RM in heritable skin diseases? 2) What are the repair mechanisms in RM? 3) When do the revertant mutations occur? 4) How do you recognize revertant skin? 5) Do the areas of RM change in size? The answers to these questions allow us to acquire knowledge on these reverted cells, the mechanisms of RM, and utility of the reverted cells to the advantage of the patient. The revertant skin could potentially be used to treat the patient's own affected skin.

USGS46 Greenland ice core water – A new isotopic reference material for δ2H and δ18O measurements of water

USGS Publications Warehouse

Coplen, Tyler B.; Qi, Haiping; Tarbox, Lauren V.; Lorenz, Jennifer M.; Buck, Bryan

2015-01-01

Ice core from Greenland was melted, filtered, homogenised, loaded into glass ampoules, sealed, autoclaved to eliminate biological activity, and calibrated by dual-inlet isotope-ratio mass spectrometry. This isotopic reference material (RM), USGS46, is intended as one of two secondary isotopic reference waters for daily normalisation of stable hydrogen (δ2H) and stable oxygen (δ18O) isotopic analysis of water with a mass spectrometer or a laser absorption spectrometer. The measured δ2H and δ18O values of this reference water were −235.8 ± 0.7‰ and −29.80 ± 0.03‰, respectively, relative to VSMOW on scales normalised such that the δ2H and δ18O values of SLAP reference water are, respectively, −428 and −55.5‰. Each uncertainty is an estimated expanded uncertainty (U = 2uc) about the reference value that provides an interval that has about a 95-percent probability of encompassing the true value. This reference water is available in cases containing 144 glass ampoules that are filled with either 4 ml or 5 ml of water per ampoule.

U.S. Department of Energy Reference Model Program RM2: Experimental Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hill, Craig; Neary, Vincent Sinclair; Gunawan, Budi

2014-08-01

The Reference Model Project (RMP), sponsored by the U.S. Department of Energy’s (DOE) Wind and Water Power Technologies Program within the Office of Energy Efficiency & Renewable Energy (EERE), aims at expediting industry growth and efficiency by providing non-proprietary Reference Models (RM) of MHK technology designs as study objects for open-source research and development (Neary et al. 2014a,b). As part of this program, MHK turbine models were tested in a large open channel facility at the University of Minnesota’s St. Anthony Falls Laboratory (UMN - SAFL) . Reference Model 2 (RM2) is a 1:15 geometric scale dual - rotor crossmore » flow vertical axis device with counter - rotating rotors, each with a rotor diameter d T = 0.43m and rotor height, h T = 0.323 m. RM2 is a river turbine designed for a site modeled after a reach in the lower Mississippi River near Baton Rouge, Louisiana (Barone et al. 2014) . Precise blade angular position and torque measurements were synchronized with three acoustic Doppler velocimeters (ADV) aligned with each rotor and the midpoint for RM2 . Flow conditions for each case were controlled such that depth, h = 1m, and volumetric flow rate, Q w = 2. 35m 3s -1 , resulting in a hub height velocity of approximately U hub = 1. 2 ms -1 and blade chord length Reynolds numbers of Re c = 6 .1x10 4. Vertical velocity profiles collected in the wake of each device from 1 to 10 rotor diameters are used to estimate the velocity recovery and turbulent characteristics in the wake, as well as the interaction of the counter-rotating rotor wakes. The development of this high resolution laboratory investigation provides a robust dataset that enables assessing computational fluid dynamics (CFD) models and their ability to accurately simulate turbulent inflow environments, device performance metrics, and to reproduce wake velocity deficit, recovery and higher order turbulent statistics.« less

Identifying the location of the OMP separatrix in DIII-D using power accounting

DOE PAGES

Stangeby, Peter C.; Canik, John M.; Elder, J. D.; ...

2015-08-07

In order to identify reliable scalings for the scrape-off layer (SOL) power width it is necessary to know the location of the separatrix in divertor tokamaks as accurately as possible, specifically its location at the outside midplane (OMP) the standard reference location. Two methods are described which use power accounting to improve the accuracy of identifying the location of the OMP separatrix. The first uses the infrared-measured deposited power profile at the outer target as the primary input, the 'more » $$P_{{\\rm SOL}}^{{\\rm exhaust}}$$ method'. The second uses the measured power input to the SOL, obtained by subtracting the power radiated from inside the separatrix from the total heating power, the ' $$P_{{\\rm SOL}}^{{\\rm input}}$$ method'. Furthermore, these two power accounting methods are illustrated with the examples of 21 H-mode DIII-D discharges. High spatial resolution Thomson scattering measured profiles of ne and Te for the main SOL near the OMP are also used as primary input to the analysis; only between-edge localized mode data are used here. The Thomson profiles are used to calculate the electron parallel conducted heat flux profiles which are then matched to the measured $$P_{{\\rm SOL}}^{{\\rm exhaust}}$$ and $$P_{{\\rm SOL}}^{{\\rm input}}$$ by adjusting the location of the OMP separatrix relative to that of the Thomson data. For these attached discharges, it is found that the values of $$R_{{\\rm sep}}^{{\\rm omp}}$$ given by the two power accounting methods agree to within ~1 mm of each other and also to within ~1 mm of the values given by the 'standard DIII-D method' described by Porter et al (1998 Phys. Plasmas 5 1410). Lastly, the shifted $$R_{{\\rm sep}}^{{\\rm omp}}$$ results in only modest changes to the values of ne and Te at the OMP separatrix relative to the 'standard' values, increasing $$n_{{\\rm e}}^{{\\rm sep}}$$ by 8% and $$T_{{\\rm e}}^{{\\rm sep}}$$ by 20%.« less

Interference removals on Pd, Ru and Au with ICP-QQQ-MS in PGE RM

NASA Astrophysics Data System (ADS)

Nadeem Hussain Bokhari, Syed; Meisel, Thomas; Walkner, Christoph

2015-04-01

Gold and platinum group elements (PGE) are essential industrial precious metals with high world demand due to their unique properties. Struggle for natural exploration of PGE is on great pace and recycling from industrial wastes, electronics and catalytic convertor is on the rise for PGE supply chain. Along with these developments it is becoming more challenging for analytical chemists to determine gold and PGE out of complex matrix which causes severe interferences. The current state of art is online analysis coupled with chromatographic separation of interferences. The ICP-QQQ-MS Agilent 8800 has the capability of using multi tunes and mass shifts. We aim to remove interferences on Pd+ (for direct and isotope dilution analysis) Au+ and Ru+ in lieu of chemical separations. YO+, SrOH+, ZnAr+, NiAr+, ZrO+, CuAr+, MoO+ , Ru+and Cd+ are expected interferences on Pd+ while Au+ is interfered by TaO+, HfOH+, GdAr+ and 102Ru+ ,104Ru+ by 102Pd+ ,104Pd+ etc. Initial test were performed on pure solutions of 1mg/l (interfering elements): 1 ng/l (Pd, Ru & Au) respectively. The outcomes of initial tests were applied on PGE reference material (RM) WMG-1 and SARM-7 (digested with Na2O2 sintering). The results obtained show that YO+, SrOH+ interfere (104Pd,105Pd), 104 Ru+ on (104Pd), ZnAr+ has slight interference on (104Pd and106Pd), ZrO+, NiAr+, CuAr+ interferences are negligible, MoO+ has severe interference on (108Pd, 110Pd) and that Cd+ has severe isobaric interference on (106Pd,108Pd, 110Pd). These interference have been removed by formation of Pd(NH3)3+complex. The TaO+, HfOH+ and GdAr+ interferences on Au+ are best removed by formation of Au(NH3)+ and Au(NH3)2+ complexes. 102Pd+,104Pd+interference on 102Ru+ ,104Ru+ can be removed by formation of Ru(NH3)4+ and RuO+ compounds. The results obtained comply with certified values of RM. The developed method is being tested on low concentration PGE reference materials. References: Sugiyama, N. " Removal of complex spectral interferences on noble metal isotopes." Agilent 8800 ICP-QQQ Application Handbook, 2014, 42-46.

The use of reference materials in quality assurance programmes in food microbiology laboratories.

PubMed

In't Veld, P H

1998-11-24

Nine different reference materials (RMs) for use in food and water microbiology have been developed with the support of the European Commission (EC). The production process of RMs is based on spray drying bacteria suspended in milk. The highly contaminated milk powder (HCMP) obtained is mixed with sterile milk powder to achieve the desired level of contamination and is subsequently filled into gelatine capsules. The HCMP may need to be stabilised by storage for more than a year before a stable RM can be prepared. The HCMP are mixed with sterile milk powder using a pestle and mortar in order to produce homogeneous RMs. For routine use of RMs Shewhart control charts can be produced. Based on log10 transformed counts, control limits are calculated. Rules for the interpretation of results facilitate the detection of out of control situations. Besides RMs there are also CRMs (Certified Reference Materials) that are certified by the EC Community Bureau of Reference (BCR) and are intended for occasional use. Based on the BCR certificate, user tables are produced presenting the 95% confidence limits for the number of capsules likely to be examined in practice. Also power analysis is made to indicate the minimum difference between the certified value and the observed geometric mean value in relation to the number of capsules examined.

The Growth and Characterization of the Bismuth Strontium-Calcium 2212 Superconductor

NASA Astrophysics Data System (ADS)

Moulton, Linda Vidale

A miniaturized float zone technique, sometimes referred to as the Laser-heated Pedestal Growth (LHPG) method, was used to produce high quality crystals of the incongruently melting rm Bi_2Sr_2CaCu _2O_{8+delta} (2212) superconductor. The main focus of this research was to (1) produce superconducting samples having different compositions, (2) identify the melt compositions and growth temperatures which produced these samples, and (3) determine the variation of their superconducting transition temperature (T _{rm C}) with composition and processing conditions. The rm Bi_2(Sr,Ca) _3Cu_2O_{8+delta} crystallization experiments were supplemented by a series of similar experiments on the incongruently melting compound rm Ca_3Al_2O_6. The phase equilibria in the CaO-rm Al_2O _3 system has been thoroughly studied, and by analyzing the float-zone growth of this simpler and better-characterized material, it was verified that phase equilibria information and solidification behavior could be extracted from and explained by these solidification experiments. Two different types of nonplanar, crystal/melt interface morphologies were observed in the rm Ca_3Al_2O_6 experiments. Each reflected the influence of the phase equilibria in the CaO-rm Al_2O_3 system and component segregation in the melt. The molten zone compositions were found to approach those predicted by the CaO-rm Al_2O_3 phase diagram as the growth rate decreased, in accordance with the Burton-Prim Slichter relationship. Excellent agreement was obtained between actual phases found to coexist at the rm Ca_3Al_2O_6 /melt interface and the predictions of classical crystal growth theory. Based on the results of the rm Ca _3Al_2O_6 crystallization study, the crystal/melt equilibria in the far more complex rm Bi_2O_3-SrO-CaO-CuO system was evaluated by determining the phases formed during the superconductor growth experiments. The melt compositions were found to be rm Bi_2O_3 -rich and SrO-poor relative to the compositions of the 2212 crystals grown from them. The CaO and CuO segregation coefficients, on the other hand, were observed to be near unity. As one would expect for an incongruently -melting compound, segregation at the solidification front generally decreased with increasing crystallization temperature, but all the segregation coefficients were not observed to simultaneously approach unity. The superconducting transition temperatures (T _{rm C}'s) of six as-crystallized samples having homogeneous crystal compositions were also measured. Sample T_{rm C} was observed to increase with increasing growth temperature and, therefore, change with crystal composition. The results of this study suggested that it is desirable to grow crystals at the highest possible crystallization temperature since they will: (1) have the highest as-grown T_{rm C} 's, and (2) solidify with the least component segregation at the growth interface. In addition, the analysis presented here suggests that such growth is not recommended at higher growth rates, since crystals with mid-range solidus compositions (and consequently, moderate growth temperatures) should crystallize most reliably as single-phase samples at higher growth rates.

RANS Simulation (Rotating Reference Frame Model [RRF]) of Single Full Scale DOE RM1 MHK Turbine

DOE Data Explorer

Javaherchi, Teymour; Stelzenmuller, Nick; Aliseda, Alberto

2013-04-10

Attached are the .cas and .dat files for the Reynolds Averaged Navier-Stokes (RANS) simulation of a single full scale DOE RM1 turbine implemented in ANSYS FLUENT CFD-package. In this case study taking advantage of the symmetry of the DOE RM1 geometry, only half of the geometry is modeled using (Single) Rotating Reference Frame model [RRF]. In this model RANS equations, coupled with k-\\omega turbulence closure model, are solved in the rotating reference frame. The actual geometry of the turbine blade is included and the turbulent boundary layer along the blade span is simulated using wall-function approach. The rotation of the blade is modeled by applying periodic boundary condition to sets of plane of symmetry. This case study simulates the performance and flow field in both the near and far wake of the device at the desired operating conditions. The results of these simulations showed good agreement to the only publicly available numerical simulation of the device done in the NREL. Please see the attached paper.

Genome characterization of a breeding line derived from a cross between Oryza sativa and Oryza rufipogon.

PubMed

Keong, B P; Harikrishna, J A

2012-02-01

A preliminary screening was conducted on BC3F1 and BC4F1 backcross families developed from crossing Oryza sativa (MR219) and O. rufipogon (IRGC105491). Despite earlier results showing that O. rufipogon alleles (wild introgression) contributed to both number of panicles (qPPL-2) and tillers (qTPL-2) at loci RM250, RM208, and RM48 in line A20 of the BC2F2 population, we observed that wild introgression was lost at loci RM250 and RM208 but retained at locus RM48 in BC3F1 and BC4F1. Progeny tests conducted utilizing genotype and phenotype data on both BC4F1 and a reference population, BC2F7 (A20 line), did not show significant differences between groups having the MR219 allele and wild introgression at locus RM48. This suggests that there is no additive and transgressive effect of wild introgression in the BC3F1 and BC4F1 generated. The presence of wild introgression was largely due to gene contamination by cross-pollination during field breeding practices.

Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards.

PubMed

French, Anna; Bravery, Christopher; Smith, James; Chandra, Amit; Archibald, Peter; Gold, Joseph D; Artzi, Natalie; Kim, Hae-Won; Barker, Richard W; Meissner, Alexander; Wu, Joseph C; Knowles, Jonathan C; Williams, David; García-Cardeña, Guillermo; Sipp, Doug; Oh, Steve; Loring, Jeanne F; Rao, Mahendra S; Reeve, Brock; Wall, Ivan; Carr, Andrew J; Bure, Kim; Stacey, Glyn; Karp, Jeffrey M; Snyder, Evan Y; Brindley, David A

2015-03-01

There is a need for physical standards (reference materials) to ensure both reproducibility and consistency in the production of somatic cell types from human pluripotent stem cell (hPSC) sources. We have outlined the need for reference materials (RMs) in relation to the unique properties and concerns surrounding hPSC-derived products and suggest in-house approaches to RM generation relevant to basic research, drug screening, and therapeutic applications. hPSCs have an unparalleled potential as a source of somatic cells for drug screening, disease modeling, and therapeutic application. Undefined variation and product variability after differentiation to the lineage or cell type of interest impede efficient translation and can obscure the evaluation of clinical safety and efficacy. Moreover, in the absence of a consistent population, data generated from in vitro studies could be unreliable and irreproducible. Efforts to devise approaches and tools that facilitate improved consistency of hPSC-derived products, both as development tools and therapeutic products, will aid translation. Standards exist in both written and physical form; however, because many unknown factors persist in the field, premature written standards could inhibit rather than promote innovation and translation. We focused on the derivation of physical standard RMs. We outline the need for RMs and assess the approaches to in-house RM generation for hPSC-derived products, a critical tool for the analysis and control of product variation that can be applied by researchers and developers. We then explore potential routes for the generation of RMs, including both cellular and noncellular materials and novel methods that might provide valuable tools to measure and account for variation. Multiparametric techniques to identify "signatures" for therapeutically relevant cell types, such as neurons and cardiomyocytes that can be derived from hPSCs, would be of significant utility, although physical RMs will be required for clinical purposes. ©AlphaMed Press.

Enabling Consistency in Pluripotent Stem Cell-Derived Products for Research and Development and Clinical Applications Through Material Standards

PubMed Central

Bravery, Christopher; Smith, James; Chandra, Amit; Archibald, Peter; Gold, Joseph D.; Artzi, Natalie; Kim, Hae-Won; Barker, Richard W.; Meissner, Alexander; Wu, Joseph C.; Knowles, Jonathan C.; Williams, David; García-Cardeña, Guillermo; Sipp, Doug; Oh, Steve; Loring, Jeanne F.; Rao, Mahendra S.; Reeve, Brock; Wall, Ivan; Carr, Andrew J.; Bure, Kim; Stacey, Glyn; Karp, Jeffrey M.

2015-01-01

Summary There is a need for physical standards (reference materials) to ensure both reproducibility and consistency in the production of somatic cell types from human pluripotent stem cell (hPSC) sources. We have outlined the need for reference materials (RMs) in relation to the unique properties and concerns surrounding hPSC-derived products and suggest in-house approaches to RM generation relevant to basic research, drug screening, and therapeutic applications. hPSCs have an unparalleled potential as a source of somatic cells for drug screening, disease modeling, and therapeutic application. Undefined variation and product variability after differentiation to the lineage or cell type of interest impede efficient translation and can obscure the evaluation of clinical safety and efficacy. Moreover, in the absence of a consistent population, data generated from in vitro studies could be unreliable and irreproducible. Efforts to devise approaches and tools that facilitate improved consistency of hPSC-derived products, both as development tools and therapeutic products, will aid translation. Standards exist in both written and physical form; however, because many unknown factors persist in the field, premature written standards could inhibit rather than promote innovation and translation. We focused on the derivation of physical standard RMs. We outline the need for RMs and assess the approaches to in-house RM generation for hPSC-derived products, a critical tool for the analysis and control of product variation that can be applied by researchers and developers. We then explore potential routes for the generation of RMs, including both cellular and noncellular materials and novel methods that might provide valuable tools to measure and account for variation. Multiparametric techniques to identify “signatures” for therapeutically relevant cell types, such as neurons and cardiomyocytes that can be derived from hPSCs, would be of significant utility, although physical RMs will be required for clinical purposes. PMID:25650438

Small-Amplitude Richtmyer-Meshkov Instability at a Re-Shocked Material Interface

NASA Astrophysics Data System (ADS)

Velikovich, A. L.; Zalesak, S. T.; Metzler, N.; Aglitskiy, Y.

2008-11-01

We report an exact small-amplitude theory of the Richtmyer-Meshkov (RM) instability developing at a re-shocked material interface and favorably compare it to our simulations. The re-shock is seen to restart the classical RM instability growth from a larger initial amplitude, at a higher rate, and change its direction from heavy-to-light to light-to heavy and vice versa. Similarly, if a Rayleigh-Taylor (RT) unstable interface is strongly re-shocked from either the heavy or light fluid side, the fast RM growth is triggered. If a RT-unstable ablation front is re-shocked, it exhibits the ablative RM-instability, that is, low-frequency decaying oscillations [V. N. Goncharov, PRL 82, 2091 (1998); Y. Aglitskiy et al., PRL 87, 265001 (2001)]. This is predicted for colliding foil experiments on the Nike laser, where a RT-unstable ablation front is re-shocked by the strong shock wave produced in the collision of the laser-driven plastic foil with a stationary foam layer. The re-shock stops the acceleration and switches the perturbation evolution from the ablative RT to the ablative RM regime.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, F.; Zhao, G.; Fosbury, R. A. E.

Due to stellar rotation, the observed radial velocity of a star varies during the transit of a planet across its surface, a phenomenon known as the Rossiter–McLaughlin (RM) effect. The amplitude of the RM effect is related to the radius of the planet which, because of differential absorption in the planetary atmosphere, depends on wavelength. Therefore, the wavelength-dependent RM effect can be used to probe the planetary atmosphere. We measure for the first time the RM effect of the Earth transiting the Sun using a lunar eclipse observed with the ESO High Accuracy Radial velocity Planet Searcher spectrograph. We analyzemore » the observed RM effect at different wavelengths to obtain the transmission spectrum of the Earth’s atmosphere after the correction of the solar limb-darkening and the convective blueshift. The ozone Chappuis band absorption as well as the Rayleigh scattering features are clearly detectable with this technique. Our observation demonstrates that the RM effect can be an effective technique for exoplanet atmosphere characterization. Its particular asset is that photometric reference stars are not required, circumventing the principal challenge for transmission spectroscopy studies of exoplanet atmospheres using large ground-based telescopes.« less

Mobility and Device Applications of Heavily Doped Silicon and Strained SILICON(1-X) Germanium(x) Layers

NASA Astrophysics Data System (ADS)

Carns, Timothy Keith

With the advent of Si molecular beam epitaxy (Si -MBE), a significant amount of research has occurred to seek alternative high conductivity Si-based materials such as rm Si_{1-x}Ge_ {x} and delta-doped Si. These materials have brought improvements in device speeds and current drives with the added advantage of monolithic integration into Si VLSI circuits. The bulk of research in Si-based materials has been devoted to the implementation of strained rm Si_{1-x}Ge_{x} as the base layer of a rm Si_ {1-x}Ge_{x}/Si heterojunction bipolar transistor (HBT). Because of the valence band offset, the rm Si_{1-x}Ge _{x} layer can be heavily doped, leading to lower base sheet resistances and hence, improved speed performances. The Ge content in the base can also be graded to increase the drift field in the base. However, very few hole mobility measurements have been done in these strained layers, leading to limitations in device modeling and in understanding the transport behavior in this important material. In addition to rm Si_{1 -x}Ge_{x}, much potential also exists in using delta-doping in Si for improved conductivities over those of bulk Si. However, as of yet, delta-doped Si has received little attention. Therefore, this dissertation is dedicated to the investigation of both of these Si-based materials (strained rm Si_{1-x}Ge_{x } and delta-doped Si and rm Si_{1-x}Ge_ {x}) for the purpose of obtaining higher conductivities than comparably doped bulk Si. This work is divided into three parts to accomplish this objective. The first part is contained in Chapter 3 and is comprised of a comprehensive characterization of the hole mobility in compressively strained rm Si_{1 -x}Ge_{x}. Few results have been obtained prior to this research which has led to many inaccuracies in device modeling. The second part of this dissertation in Chapters 4 and 5 is devoted to the study of the mobility behavior in both boron and antimony delta-doped Si and rm Si_ {1-x}Ge_{x}. The important discovery of mobility and conductivity enhancement in coupled delta-doped layers is highlighted in Chapter 5. Finally, the third part of this work discusses the implementation of boron delta -doped layers in Si homojunction bipolar transistors and FETs. Chapter 6 includes the fabrication of the first coupled delta-doped base layer Si BJT, the first p-type Si delta-doped layer MESFET, the first coupled delta -doped layer FET, and the first SiGe delta -FET.

U.S. Department of Energy Reference Model Program RM1: Experimental Results.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hill, Craig; Neary, Vincent Sinclair; Gunawan, Budi

The Reference Model Project (RMP), sponsored by the U.S. Department of Energy’s (DOE) Wind and Water Power Technologies Program within the Office of Energy Efficiency & Renewable Energy (EERE), aims at expediting industry growth and efficiency by providing nonproprietary Reference Models (RM) of MHK technology designs as study objects for opensource research and development (Neary et al. 2014a,b). As part of this program, MHK turbine models were tested in a large open channel facility at the University of Minnesota’s St. Anthony Falls Laboratory (UMN-SAFL). Reference Model 1 (RM1) is a 1:40 geometric scale dual-rotor axial flow horizontal axis device withmore » counter-rotating rotors, each with a rotor diameter dT = 0.5m. Precise blade angular position and torque measurements were synchronized with three acoustic Doppler velocimeters (ADVs) aligned with each rotor and the midpoint for RM1. Flow conditions for each case were controlled such that depth, h = 1m, and volumetric flow rate, Qw = 2.425m3s-1, resulting in a hub height velocity of approximately Uhub = 1.05ms-1 and blade chord length Reynolds numbers of Rec ≈ 3.0x105. Vertical velocity profiles collected in the wake of each device from 1 to 10 rotor diameters are used to estimate the velocity recovery and turbulent characteristics in the wake, as well as the interaction of the counter-rotating rotor wakes. The development of this high resolution laboratory investigation provides a robust dataset that enables assessing turbulence performance models and their ability to accurately predict device performance metrics, including computational fluid dynamics (CFD) models that can be used to predict turbulent inflow environments, reproduce wake velocity deficit, recovery and higher order turbulent statistics, as well as device performance metrics.« less

Physiologic effects of rhythmical massage: a prospective exploratory cohort study.

PubMed

Wälchli, Chantal; Saltzwedel, Georg; Krüerke, Daniel; Kaufmann, Christoph; Schnorr, Bettina; Rist, Lukas; Eberhard, Jutta; Decker, Michael; Simões-Wüst, Ana Paula

2014-06-01

This study was performed to characterize the physiologic effects of rhythmical massage (RM), an anthroposophic therapy whose effectiveness is supported by empirical observations and a prospective observational study. Patients referred to RM at the Paracelsus Hospital Richterswil for any indication were continuously enrolled. They received an average of 10 RM sessions, which included not only the massage but also therapeutic rest in the supine position immediately thereafter. Effects of RM on surface temperature and on heart rate variability (HRV) were determined with infrared imaging (IRI) and electrocardiography (ECG), respectively. IRI of the patients' dorsal region was performed without clothes, in standing position, at the start and at the end of two waiting periods before and after RM. ECG was performed from the beginning of the first waiting period until the end of the second one. Results on IRI from 9 and ECG from 11 patients could be analyzed. RM led to an immediate increase in dorsal temperature. Furthermore, comparison of the IRI images for consecutive RM sessions showed a tendency toward improved warmth distribution as a progressive therapy effect. Analysis of the EGC results recorded during the waiting periods-in the sitting position--showed a significant increase of HRV after RM, as detected by the standard deviation of the beat-to-beat periods and a relative increase of low-frequency power. During the course of the RM sessions, the change in HRV during the therapeutic rest period depended on the initial value: Low initial values were enhanced, whereas high ones were reduced. RM led to an immediate increase in the patient's dorsal surface temperature, as well as increased HRV and sympathetic stimulation. In the long term, RM resulted in a progressive improvement of warmth distribution and regulation of the resting HRV.

Regenerative medicine in Brazil: small but innovative.

PubMed

McMahon, Dominique S; Singer, Peter A; Daar, Abdallah S; Thorsteinsdóttir, Halla

2010-11-01

Although Brazil has received attention for conducting one of the world's largest stem cell clinical trials for heart disease, little has been published regarding Brazil's regenerative medicine (RM) sector. Here we present a comprehensive case study of RM in Brazil, including analysis of the current activity, the main motivations for engaging in RM and the remaining challenges to development in this field. Our case study is primarily based on semi-structured interviews with experts on RM in Brazil, including researchers, policymakers, clinicians, representatives of firms and regulators. Driven by domestic health needs and strategic government support, Brazil is producing innovative RM research, particularly for clinical research in cardiology, orthopedics, diabetes and neurology. We describe the main RM research currently taking place in Brazil, as well as some of the economic, regulatory and policy events that have created a favorable environment for RM development. Brazilian RM researchers need to overcome several formidable challenges to research: research funding is inconsistent, importation of materials is costly and slow, and weak linkages between universities, hospitals and industry impede translational research. Although Brazil's contribution to the RM sector is small, its niche emphasis on clinical applications may become of global importance, particularly if Brazil manages to address the challenges currently impinging on RM innovation.

Towards a nondestructive chemical characterization of biofilm matrix by Raman microscopy.

PubMed

Ivleva, Natalia P; Wagner, Michael; Horn, Harald; Niessner, Reinhard; Haisch, Christoph

2009-01-01

In this study, the applicability of Raman microscopy (RM) for nondestructive chemical analysis of biofilm matrix, including microbial constituents and extracellular polymeric substances (EPS), has been assessed. The examination of a wide range of reference samples such as biofilm-specific polysaccharides, proteins, microorganisms, and encapsulated bacteria revealed characteristic frequency regions and specific marker bands for different biofilm constituents. Based on received data, the assignment of Raman bands in spectra of multispecies biofilms was performed. The study of different multispecies biofilms showed that RM can correlate various structural appearances within the biofilm to variations in their chemical composition and provide chemical information about a complex biofilm matrix. The results of RM analysis of biofilms are in good agreement with data obtained by confocal laser scanning microscopy (CLSM). Thus, RM is a promising tool for a label-free chemical characterization of different biofilm constituents. Moreover, the combination of RM with CLSM analysis for the study of biofilms grown under different environmental conditions can provide new insights into the complex structure/function correlations in biofilms.

Von Kármán between Aachen and Pasadena

NASA Astrophysics Data System (ADS)

Krause, Egon; Kalkmann, Ulrich

2013-05-01

In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

Using inductively coupled plasma-mass spectrometry for calibration transfer between environmental CRMs.

PubMed

Turk, G C; Yu, L L; Salit, M L; Guthrie, W F

2001-06-01

Multielement analyses of environmental reference materials have been performed using existing certified reference materials (CRMs) as calibration standards for inductively coupled plasma-mass spectrometry. The analyses have been performed using a high-performance methodology that results in comparison measurement uncertainties that are significantly less than the uncertainties of the certified values of the calibration CRM. Consequently, the determined values have uncertainties that are very nearly equivalent to the uncertainties of the calibration CRM. Several uses of this calibration transfer are proposed, including, re-certification measurements of replacement CRMs, establishing traceability of one CRM to another, and demonstrating the equivalence of two CRMs. RM 8704, a river sediment, was analyzed using SRM 2704, Buffalo River Sediment, as the calibration standard. SRM 1632c, Trace Elements in Bituminous Coal, which is a replacement for SRM 1632b, was analyzed using SRM 1632b as the standard. SRM 1635, Trace Elements in Subbituminous Coal, was also analyzed using SRM 1632b as the standard.

Silicon isotope amount ratios and molar masses for two silicon isotope reference materials: IRMM-018a and NBS28

NASA Astrophysics Data System (ADS)

Valkiers, S.; Ding, T.; Inkret, M.; Ruße, K.; Taylor, P.

2005-04-01

A new 2 kg batch of SiO2 crystals, IRMM-018a as well as the existing NBS28 silica sand (or RM 8546, obtained by I. Friedman from U.S. Geological Survey) have been characterised for their "absolute" silicon isotope composition and molar mass. The amount-of-substance measurements needed for that purpose were performed on the IRMM amount comparator (Avogadro II) on samples from these batches, which were converted to gaseous silicon tetra-fluoride (SiF4). The isotope amount ratio measurements were calibrated by means of synthesized isotope amount ratios realized in the form of synthetic Si isotope mixtures, the measurement procedure of which makes them SI-traceable. IRMM-018a is intended to be used as Isotope Reference Material for isotope amount measurements in geochemical and other isotope abundance studies of silicon. It is distributed in samples of about 0.1 mol and will replace IRMM-018 (exhausted).

Development of a highly precise ID-ICP-SFMS method for analysis of low concentrations of lead in rice flour reference materials.

PubMed

Zhu, Yanbei; Inagaki, Kazumi; Yarita, Takashi; Chiba, Koichi

2008-07-01

Microwave digestion and isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-SFMS) has been applied to the determination of Pb in rice flour. In order to achieve highly precise determination of low concentrations of Pb, the digestion blank for Pb was reduced to 0.21 ng g(-1) after optimization of the digestion conditions, in which 20 mL analysis solution was obtained after digestion of 0.5 g rice flour. The observed value of Pb in a non-fat milk powder certified reference material (CRM), NIST SRM 1549, was 16.8 +/- 0.8 ng g(-1) (mean +/- expanded uncertainty, k = 2; n = 5), which agreed with the certified value of 19 +/- 3 ng g(-1) and indicated the effectiveness of the method. Analytical results for Pb in three brown rice flour CRMs, NIST SRM 1568a, NIES CRM 10-a, and NIES CRM 10-b, were 7.32 +/- 0.24 ng g(-1) (n = 5), 1010 +/- 10 ng g(-1) (n = 5), and 1250 +/- 20 ng g(-1) (n = 5), respectively. The concentration of Pb in a candidate white rice flour reference material (RM) sample prepared by the National Metrology Institute of Japan (NMIJ) was observed to be 4.36 +/- 0.28 ng g(-1) (n = 10 bottles).

Trigger-happy resident memory CD4+ T cells inhabit the human lungs.

PubMed

Oja, A E; Piet, B; Helbig, C; Stark, R; van der Zwan, D; Blaauwgeers, H; Remmerswaal, E B M; Amsen, D; Jonkers, R E; Moerland, P D; Nolte, M A; van Lier, R A W; Hombrink, P

2018-05-01

Resident memory T cells (T RM ) reside in the lung epithelium and mediate protective immunity against respiratory pathogens. Although lung CD8 + T RM have been extensively characterized, the properties of CD4 + T RM remain unclear. Here we determined the transcriptional signature of CD4 + T RM , identified by the expression of CD103, retrieved from human lung resection material. Various tissue homing molecules were specifically upregulated on CD4 + T RM , whereas expression of tissue egress and lymph node homing molecules were low. CD103 + T RM expressed low levels of T-bet, only a small portion expressed Eomesodermin (Eomes), and although the mRNA levels for Hobit were increased, protein expression was absent. On the other hand, the CD103 + T RM showed a Notch signature. CD4 + CD103 + T RM constitutively expressed high transcript levels of numerous cytotoxic mediators that was functionally reflected by a fast recall response, magnitude of cytokine production, and a high degree of polyfunctionality. Interestingly, the superior cytokine production appears to be because of an accessible interferon-γ (IFNγ) locus and was partially because of rapid translation of preformed mRNA. Our studies provide a molecular understanding of the maintenance and potential function of CD4 + T RM in the human lung. Understanding the specific properties of CD4 + T RM is required to rationally improve vaccine design.

Iron Disilicide as High-Temperature Reference Material for Traceable Measurements of Seebeck Coefficient Between 300 K and 800 K

NASA Astrophysics Data System (ADS)

Ziolkowski, Pawel; Stiewe, Christian; de Boor, Johannes; Druschke, Ines; Zabrocki, Knud; Edler, Frank; Haupt, Sebastian; König, Jan; Mueller, Eckhard

2017-01-01

Thermoelectric generators (TEGs) convert heat to electrical energy by means of the Seebeck effect. The Seebeck coefficient is a central thermoelectric material property, measuring the magnitude of the thermovoltage generated in response to a temperature difference across a thermoelectric material. Precise determination of the Seebeck coefficient provides the basis for reliable performance assessment in materials development in the field of thermoelectrics. For several reasons, measurement uncertainties of up to 14% can often be observed in interlaboratory comparisons of temperature-dependent Seebeck coefficient or in error analyses on currently employed instruments. This is still too high for an industrial benchmark and insufficient for many scientific investigations and technological developments. The TESt (thermoelectric standardization) project was launched in 2011, funded by the German Federal Ministry of Education and Research (BMBF), to reduce measurement uncertainties, engineer traceable and precise thermoelectric measurement techniques for materials and TEGs, and develop reference materials (RMs) for temperature-dependent determination of the Seebeck coefficient. We report herein the successful development and qualification of cobalt-doped β-iron disilicide ( β-Fe0.95Co0.05Si2) as a RM for high-temperature thermoelectric metrology. A brief survey on technological processes for manufacturing and machining of samples is presented. Focus is placed on metrological qualification of the iron disilicide, results of an international round-robin test, and final certification as a reference material in accordance with ISO-Guide 35 and the "Guide to the expression of uncertainty in measurement" by the Physikalisch-Technische Bundesanstalt, the national metrology institute of Germany.

An effective XML based name mapping mechanism within StoRM

NASA Astrophysics Data System (ADS)

Corso, E.; Forti, A.; Ghiselli, A.; Magnoni, L.; Zappi, R.

2008-07-01

In a Grid environment the naming capability allows users to refer to specific data resources in a physical storage system using a high level logical identifier. This logical identifier is typically organized in a file system like structure, a hierarchical tree of names. Storage Resource Manager (SRM) services map the logical identifier to the physical location of data evaluating a set of parameters as the desired quality of services and the VOMS attributes specified in the requests. StoRM is a SRM service developed by INFN and ICTP-EGRID to manage file and space on standard POSIX and high performing parallel and cluster file systems. An upcoming requirement in the Grid data scenario is the orthogonality of the logical name and the physical location of data, in order to refer, with the same identifier, to different copies of data archived in various storage areas with different quality of service. The mapping mechanism proposed in StoRM is based on a XML document that represents the different storage components managed by the service, the storage areas defined by the site administrator, the quality of service they provide and the Virtual Organization that want to use the storage area. An appropriate directory tree is realized in each storage component reflecting the XML schema. In this scenario StoRM is able to identify the physical location of a requested data evaluating the logical identifier and the specified attributes following the XML schema, without querying any database service. This paper presents the namespace schema defined, the different entities represented and the technical details of the StoRM implementation.

Bilateral hydronephrosis

MedlinePlus

... general problems with urination. Alternative Names Hydronephrosis - bilateral Images Female urinary tract Male urinary tract References Elder JS. Obstruction of the urinary tract. In: Kliegman RM, ...

Strength performance in youth: trainability of adolescents and children in the back and front squats.

PubMed

Keiner, Michael; Sander, Andre; Wirth, Klaus; Caruso, Oliver; Immesberger, Peter; Zawieja, Martin

2013-02-01

A basic question for many athletic coaches pertains to the maximum attainable strength level for youth athletes. The aim of this investigation was to establish reference values for the strength performance in the front and back squats in youth athletes. The strength performance in front and back squats of 141 elite youth soccer players was tested by a 1 repetition maximum (1RM) and 1RM related to bodyweight (SREL). The subjects aged between 11 and 19 years and were divided into 2 groups and 4 subgroups (A = younger than 19 years, B = younger than 17 years, C = younger than 15 years, and D = younger than 13 years). For approximately 2 years, one group (control group [CG]) only participated in routine soccer training and the other group (strength training group [STG]) participated in an additional strength training program along with the routine soccer training. Additionally, the strength performance in a 5RM in both squat variants of 105 young elite weightlifters (National Weightlifting Organization Baden Württemberg, [BWG]) was examined to show the high level of trainability of children and adolescents and to determine the reference strength values for young athletes. The STG performed in the parallel front squat SREL in the subgroups A 1.7 +/- 0.2, B 1.6 +/- 0.2, C 1.4 +/-0.2 and D 0.9 +/- 0.3. The STG had significantly (p < 0.001) higher strength values in 1RM and SREL than CG. The BWG had higher strength values than STG, but the BWG was not part of the statistical analysis because of the different test protocols (1RM vs. 5RM). Our data show that the SREL in parallel squat for young elite athletes with long-term training experience should be a minimum of 2.0 for 16- to 19-year-olds, 1.5 for 13- to 15-year-olds, and 0.7 for 11- to 12-year-olds.

Multiple forms of rhythmic movements in an adolescent boy with rhythmic movement disorder.

PubMed

Su, Changjun; Miao, Jianting; Liu, Yu; Liu, Rui; Lei, Gesheng; Zhang, Wei; Yang, Ting; Li, Zhuyi

2009-12-01

Rhythmic movement disorder (RMD) refers to a group of stereotyped, repetitive movements involving large muscles, usually occurring prior to the onset of sleep and persisting into sleep. RMD more commonly exhibits only one or two forms of rhythmic movements (RM) in most reported cases. However, multiple RM forms of RMD occurring in a patient in the same night have rarely been reported. In this report, we present the unique case of a 15-year-old boy with RMD affected by multiple forms of RM in the same night, including four known forms (i.e., body rocking, head banging, leg rolling, and rhythmic feet movements) and two new kinds of RM (bilateral rhythmic arm rocking and rhythmic hands movements). Two video-polysomnographic recordings were performed in this patient before starting pharmacologic treatment and after long-term oral clonazepam treatment (1.0mg nightly for 3 months). The characteristics of RMD with multiple RM forms and the effectiveness of clonazepam on the RM episodes and polysomnographic findings observed in our patient are discussed. This report raises the fact that a patient with RMD may present with multiple complex rhythmic movements disrupting sleep, which emphasizes that better understanding of the clinical features of complex rhythmic movements during sleep in primary care settings is essential for early clinical diagnosis and optimal management.

Preparation of candidate reference materials for the determination of phosphorus containing flame retardants in styrene-based polymers.

PubMed

Roth, Thomas; Urpi Bertran, Raquel; Latza, Andreas; Andörfer-Lang, Katrin; Hügelschäffer, Claudia; Pöhlein, Manfred; Puchta, Ralph; Placht, Christian; Maid, Harald; Bauer, Walter; van Eldik, Rudi

2015-04-01

Candidate reference materials (RM) for the analysis of phosphorus-based flame retardants in styrene-based polymers were prepared using a self-made mini-extruder. Due to legal requirements of the current restriction for the use of certain hazardous substances in electrical and electronic equipment, focus now is placed on phosphorus-based flame retardants instead of the brominated kind. Newly developed analytical methods for the first-mentioned substances also require RMs similar to industrial samples for validation and verification purposes. Hence, the prepared candidate RMs contained resorcinol-bis-(diphenyl phosphate), bisphenol A bis(diphenyl phosphate), triphenyl phosphate and triphenyl phosphine oxide as phosphorus-based flame retardants. Blends of polycarbonate and acrylonitrile-co-butadiene-co-styrene as well as blends of high-impact polystyrene and polyphenylene oxide were chosen as carrier polymers. Homogeneity and thermal stability of the candidate RMs were investigated. Results showed that the candidate RMs were comparable to the available industrial materials. Measurements by ICP/OES, FTIR and NMR confirmed the expected concentrations of the flame retardants and proved that analyte loss and degradation, respectively, was below the uncertainty of measurement during the extrusion process. Thus, the candidate RMs were found to be suitable for laboratory use.

Predicting fractional bed load transport rates: Application of the Wilcock‐Crowe equations to a regulated gravel bed river

USGS Publications Warehouse

Gaeuman, David; Andrews, E.D.; Krause, Andreas; Smith, Wes

2009-01-01

Bed load samples from four locations in the Trinity River of northern California are analyzed to evaluate the performance of the Wilcock‐Crowe bed load transport equations for predicting fractional bed load transport rates. Bed surface particles become smaller and the fraction of sand on the bed increases with distance downstream from Lewiston Dam. The dimensionless reference shear stress for the mean bed particle size (τ*rm) is largest near the dam, but varies relatively little between the more downstream locations. The relation between τ*rm and the reference shear stresses for other size fractions is constant across all locations. Total bed load transport rates predicted with the Wilcock‐Crowe equations are within a factor of 2 of sampled transport rates for 68% of all samples. The Wilcock‐Crowe equations nonetheless consistently under‐predict the transport of particles larger than 128 mm, frequently by more than an order of magnitude. Accurate prediction of the transport rates of the largest particles is important for models in which the evolution of the surface grain size distribution determines subsequent bed load transport rates. Values of τ*rm estimated from bed load samples are up to 50% larger than those predicted with the Wilcock‐Crowe equations, and sampled bed load transport approximates equal mobility across a wider range of grain sizes than is implied by the equations. Modifications to the Wilcock‐Crowe equation for determining τ*rm and the hiding function used to scale τ*rm to other grain size fractions are proposed to achieve the best fit to observed bed load transport in the Trinity River.

Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice.

PubMed

Serrano Sponton, Lucas Ezequiel; Soria, Gonzalo Jose; Dubroqua, Sylvain; Singer, Philipp; Feldon, Joram; Gargiulo, Pascual A; Yee, Benjamin K

2018-02-26

The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Hence, performance in a given test is likely poorer if it follows the other test instead of being conducted first. Yet, the presence of such negative transfer effects (or proactive interference) between WM and RM training in the water maze is often overlooked in the literature. To gauge whether this constitutes a serious concern, the present study determined empirically the magnitude, persistence, and directionality of the transfer effect in wild-type C57BL/6 mice. We contrasted the order of tests between two cohorts of mice. Performance between the two cohorts in the WM and RM tests were then separately compared. We showed that prior training of either test significantly reduced performance in the subsequent one. The statistical effect sizes in both directions were moderate to large. Although extended training could overcome the deficit, it could re-emerge later albeit in a more transient fashion. Whenever RM and WM water maze tests are conducted sequentially in the same animals - regardless of the test order, extra caution is necessary when interpreting the outcomes in the second test. Counterbalancing test orders between animals is recommended. Copyright © 2017 Elsevier B.V. All rights reserved.

Pelvic inflammatory disease (PID)

MedlinePlus

... Names PID; Oophoritis; Salpingitis; Salpingo - oophoritis; Salpingo - peritonitis Images Pelvic laparoscopy Female reproductive anatomy Endometritis Uterus References McKinzie J. Sexually transmitted diseases. In: Walls RM, Hockberger RS, ...

Development of the QA/QC Procedures for a Neutron Interrogation System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Obhodas, Jasmina; Sudac, Davorin; Valkovic, Vladivoj

In order to perform QA/QC procedures for a system dedicated to the neutron interrogation of objects for the presence of threat materials one needs to perform measurements of reference materials (RM) having the same (or similar) atomic ratios as real materials. It is well known that explosives, drugs, and various other benign materials, contain chemical elements such as hydrogen, oxygen, carbon and nitrogen in distinctly different quantities. For example, a high carbon-to-oxygen ratio (C/O) is characteristic of drugs. Explosives can be differentiated by measurement of both C/O and nitrogen-to-oxygen (N/O) ratios. The C/N ratio of the chemical warfare agents, coupledmore » with the measurement of elements such as fluorine and phosphorus, clearly differentiate them from the conventional explosives. Correlations between theoretical values and experimental results obtained in laboratory conditions for C/O and N/C ratios of simulants of hexogen (RDX), TNT, DLM2, TATP, cocaine, heroin, yperite, tetranitromethane, peroxide methylethyl-ketone, nitromethane and ethyleneglycol dinitrate are presented. (authors)« less

Annotated Bibliographies.

ERIC Educational Resources Information Center

Totten, Sam; Alexander, Susan

1985-01-01

Intended for elementary, secondary, and college teachers, this listing cites print materials dealing with nuclear warfare. Included are nonfiction, fiction, journals, newsletters, curriculum materials, and organizations. (RM)

a New Value for the Rydberg Constant by Precision Measurement of the Hydrogen Balmer-Beta Transition.

NASA Astrophysics Data System (ADS)

Zhao, Ping

The Rydberg constant {rm R }_infty is determined to a very high accuracy of 3 parts in 10^{10 } by a direct comparison of the four hydrogen and deuterium Balmer-beta transitions with a standard laser from the National Bureau of Standards. This experiment is now the most precise measurement for {rm R}_infty and approaches the limits of accuracy for wavelength or frequency measurements in the visible region. The result is {rm R}_infty = 109 737.315 73 (3) {rm cm}^{-1} with the definition of the meter: c = 299 792 458 m/sec. The experiment also yields the following results: The fine structure splittings 4{rm P}_ {1/2} rightarrow {rm 4P}_{3/2} in H: 1370.9 (3) MHz and in D: 1371.8 (3) MHz. The isotope shifts between H and D in the transitions {rm 2S}_{1/2} rightarrow {rm 4P}_{1/2}: 167 752.4 (3) MHz and {rm 2S}_{1/2 } rightarrow {rm 4P}_{3/2}: 167 753.3 (3) MHz. The experiment utilizes atomic beam laser spectroscopy. A beam of atomic hydrogen (or deuterium) is excited by electron bombardment to the metastable {rm 2S }_{1/2} state and is detected by a secondary electron emission detector. A chopped cw dye laser beam crosses the atomic beam at an angle of 90^circ to eliminate Doppler broadening. The metastables are quenched by laser excitation to {rm 4P}_{1/2} or {rm 4P}_{3/2 } states. The signal is monitored by a lock -in amplifier with the chopper as reference. An iodine (^{127}{ rm I}_2) stabilized helium-neon (He-Ne) laser is the primary standard with an accuracy of 1.6 times 10^{ -10}. Another He-Ne laser is locked to the standard laser with a variable offset frequency controlled by an oscillator. A frequency chain is established by locking together a dye laser, a piezoelectrically controlled measuring etalon and the offset laser. This chain allows the dye laser to scan across the Balmer-beta line in a precisely controllable manner. The lineshape and offset frequency are recorded simultaneously. Possible sources of systematic shifts and errors are carefully investigated. Hydrogen energy levels are calculated according to most recent values of physical constants. {rm R}_infty is obtained by comparing the measured and calculated hydrogen Balmer-beta transition. The result is in good agreement with the two most recent, but less precise experiments.

Certification of the reference material of water content in water saturated 1-octanol by Karl Fischer coulometry, Karl Fischer volumetry and quantitative nuclear magnetic resonance.

PubMed

Wang, Haifeng; Ma, Kang; Zhang, Wei; Li, Jia; Sun, Guohua; Li, Hongmei

2012-10-15

Certified reference materials (CRMs) of water content are widely used in the calibration and validation of Karl Fischer coulometry and volumetry. In this study, the water content of the water saturated 1-octanol (WSO) CRM was certified by Karl Fischer coulometry, volumetry and quantitative nuclear magnetic resonance (Q NMR). The water content recovery by coulometry was 99.76% with a diaphragm-less electrode and Coulomat AG anolyte. The relative bias between the coulometry and volumetry results was 0.06%. In Q NMR, the water content of WSO is traceable to the International System (SI) of units through the purity of internal standard. The relative bias of water content in WSO between Q NMR and volumetry was 0.50%. The consistency of results for these three independent methods improves the accuracy of the certification of the RM. The certified water content of the WSO CRM was 4.76% with an expanded uncertainty of 0.09%. Copyright © 2012 Elsevier Ltd. All rights reserved.

The Development and Study of Molecular Electronic Switches and their Field-Effect Transistor (FET) Device Properties

DTIC Science & Technology

2015-02-27

Grand Rapids, MI) meetings and conferences. References 1. L.N Lucas, J.J.D. de Jong, J.H. van Esch, R.M. Kellogg , B.L. Berringa. Eur. J. Org...R.M. Kellogg , H.L. Feringa, H.L. Eur. J. Org. Chem., 2003, 155-166. 6. B. Qin, R. Yao, X. Zhao, H. Tian. Org. Biomol. Chem., 1, 2003, 2187-2191...7. L.N. Lucas, J.H. van Euch, R.M. Kellogg , B. Feringa. Chem. Comm., 1998, 2313-2314.

Effect of storms on Barrier Island dynamics, Core Banks, Cape Lookout National Seashore, North Carolina, 1960-2001

USGS Publications Warehouse

Riggs, Stanley R.; Ames, Dorothea V.

2007-01-01

The effect of storms on long-term dynamics of barrier islands was evaluated on Core Banks, a series of barrier islands that extend from Cape Lookout to Okracoke Inlet in the Cape Lookout National Seashore, North Carolina. Shoreline and elevation changes were determined by comparing 77 profiles and associated reference markers established by the U.S. Army Corps of Engineers (USACE) on Core Banks from June 1960 to July 1962 to a follow-up survey by Godfrey and Godfrey (G&G) in 1971 and a survey by the Department of Geology at East Carolina University (ECU) in 2001, in which 57 of the original 77 profiles were located. Evaluation of the baseline data associated with the USACE study supplies an important record of barrier island response to two specific storm events—Hurricane Donna in September 1960 and the Ash Wednesday extra-tropical cyclone in March 1962. The 1962 USACE survey was followed by 9 years characterized by no major storms; this low-energy period was captured by the G&G survey in 1971. The G&G survey was followed by 22 years characterized by occasional small to moderate storms. Starting in 1993, however, and continuing through 1999, the North Carolina coast experienced a major increase in storm activity, with seven major hurricanes impacting Core Banks. Both the USACE 1960–1962 and G&G 1962–1971 surveys produced short-term data sets that reflected very different sets of weather conditions. The ECU 2001 survey data were then compared with the USACE 1960 survey data to develop a long-term (41 years) data set for shoreline erosion on Core Banks. Those resulting long-term data were compared with the long-term (52 years) data sets by the North Carolina Division of Coastal Management (NCDCM) from 1940–1992 and 1946–1998; a strong positive correlation and very similar rates of average annual erosion resulted. However, the ECU and NCDCM long-term data sets did not correlate with either of the USACE and G&G short-term survey data and had very different average annual erosion rates. The average annual long-term rate of shoreline erosion for all of Core Banks and for both the ECU 1960–2001 and the NCDCM 1946–1998 surveys was -5 feet per year (ft/yr). These long-term rates of shoreline recession are in strong contrast with the short-term, storm-dominated rates of shoreline erosion for all of Core Banks developed by the USACE 1960–1961 and USACE 1961–1962 surveys, which have average annual erosion rates of -40 ft/yr and -26 ft/yr, respectively, and range from -226 feet (ft) to +153 ft. The combined short-term, storm-dominated shoreline erosion rate for the USACE surveys (1960–1962) was -36 ft/yr. In contrast, the average annual short-term, non-stormy period G&G 1962–1971 survey demonstrated shoreline accretion for all of Core Banks with an average annual rate of +12 ft/yr. In general, North Core Banks has higher erosion and accretion rates than South Core Banks. In the 1961 survey, the USACE installed 231 reference markers (RM-0 is closest to the ocean and RM-2 is farthest from the ocean) along the 77 profiles, as well as 33 reference markers labeled RM-4, RM-6, and RM-8 in the wider portions of the islands. The G&G survey recovered a total of 141 reference markers (61 percent), and the ECU survey recovered a total of 83 reference markers (36 percent) of the RM-0, RM-1, and RM-2 markers. The average ground elevation measured by the USACE in 1961 was RM-0 = +5.8 ft, RM-1 = +5.2 ft, and RM-2 = +4.8 ft. The G&G 1970 survey measured average ground elevations of RM-0 = +6.7 ft, RM-1 = +6.4 ft, and RM-2 = +6.1 ft, and the average ground elevation measured by ECU in 2001 was RM-0 = +10.1 ft, RM-1 = +9.1 ft, and RM-2 = +8.5 ft. The latter numbers represent approximately an overall 72-percent increase in island elevation from 1961 to 2001. Based on aerial photographic time-slice analyses, it is hypothesized that this increase in island elevation occurred during the post-1962 period with storm overwash systematically raising the island elevation through time, which in turn led to decreased numbers of overwash events. The latter processes and responses in turn led to a substantial increase in vegetative growth on the barrier island, as well as submerged aquatic vegetation on the back-barrier sand shoals. Integration of the USACE, G&G, ECU, and NCDCM shoreline erosion data for Core Banks shows several important points about shoreline recession. (1) The ECU and NCDCM data sets demonstrate that there is an ongoing net, long-term, but small-scale shoreline recession associated with Core Banks; (2) the USACE short-term data sets demonstrate that processes associated with individual storm events or sets of events produce extremely large-scale changes that include both erosion and accretion; (3) the short-term, non-stormy period data set of G&G demonstrates that if given enough time between storm events, barriers can rebuild to their pre-storm period conditions; and (4) the post-storm response generally tends to approach the pre-storm location, but rarely reaches it before the next storm or stormy period sets in. The result is the net long-term change documented by both the ECU 1960–2001 and NCDCM 1946–1998 Core Banks data sets that resulted in erosion rates ranging from 0 to -30 ft/yr with net annual average recession rates of -5 ft/yr. Analysis and comparison of these data sets supply important information for understanding the dynamics and responses of barrier island systems through time. In addition, the results of the present study on Core Banks supply essential process-response information that can be used to design and implement management plans for the Cape Lookout and Cape Hatteras National Seashores and for other seashores in the U.S. National Park Service system.

Determination of Os by isotope dilution-inductively coupled plasma-mass spectrometry with the combination of laser ablation to introduce chemically separated geological samples

NASA Astrophysics Data System (ADS)

Sun, Yali; Ren, Minghao; Xia, Xiaoping; Li, Congying; Sun, Weidong

2015-11-01

A method was developed for the determination of trace Os in geological samples by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) with the combination of chemical separation and preconcentration. Samples are digested using aqua regia in Carius tubes, and the Os analyte is converted into volatile OsO4, which is distilled and absorbed with HBr. The HBr solution is concentrated for further Os purification using the microdistillation technique. The purified Os is dissolved in 10 μl of 0.02% sucrose-0.005% H3PO4 solution and then evaporated on pieces of perfluoroalkoxy (PFA) film, resulting in the formation of a tiny object (< 3 × 104 μm2 superficial area). Using LA-ICP-MS measurements, the object can give Os signals at least 100 times higher than those provided by routine solution-ICP-MS while successfully avoiding the memory effect. The procedural blank and detection limit in the developed technique are 3.0 pg and 1.8 pg for Os, respectively when 1 g of samples is taken. Reference materials (RM) are analyzed, and their Os concentrations obtained by isotope dilution are comparable to reference or literature values. Based on the individual RM results, the precision is estimated within the range of 0.6 to 9.4% relative standard deviation (RSD), revealing that this method is applicable to the determination of trace Os in geological samples.

Pinna abnormalities and low-set ears

MedlinePlus

... Pinna abnormalities; Genetic defect - pinna; Congenital defect - pinna Images Ear abnormalities Pinna of the newborn ear References Haddad J, Keesecker S. Congenital malformations. In: Kliegman RM, Stanton BF, ...

Signatures of Relativistic Helical Motion in the Rotation Measures of Active Galactic Nucleus Jets

NASA Astrophysics Data System (ADS)

Broderick, Avery E.; Loeb, Abraham

2009-10-01

Polarization has proven to be an invaluable tool for probing magnetic fields in relativistic jets. Maps of the intrinsic polarization vectors have provided the best evidence to date for uniform, toroidally dominated magnetic fields within jets. More recently, maps of the rotation measure (RM) in jets have for the first time probed the field geometry of the cool, moderately relativistic surrounding material. In most cases, clear signatures of the toroidal magnetic field are detected, corresponding to gradients in RM profiles transverse to the jet. However, in many objects, these profiles also display marked asymmetries that are difficult to explain in simple helical jet models. Furthermore, in some cases, the RM profiles are strongly frequency and/or time dependent. Here we show that these features may be naturally accounted for by including relativistic helical motion in the jet model. In particular, we are able to reproduce bent RM profiles observed in a variety of jets, frequency-dependent RM profile morphologies, and even the time dependence of the RM profiles of knots in 3C 273. Finally, we predict that some sources may show reversals in their RM profiles at sufficiently high frequencies, depending upon the ratio of the components of jet sheath velocity transverse and parallel to the jet. Thus, multi-frequency RM maps promise a novel way in which to probe the velocity structure of relativistic outflows.

Data on crystal organization in the structure of the Fab fragment from the NIST reference antibody, RM 8671.

PubMed

Gallagher, D T; Karageorgos, I; Hudgens, J W; Galvin, C V

2018-02-01

The reported data describe the crystallization, crystal packing, structure determination and twinning of the unliganded Fab (antigen-binding fragment) from the NISTmAb (standard reference material 8671). The raw atomic coordinates are available as Protein Data Bank structure 5K8A and biological aspects are described in the article, (Karageorgos et al., 2017) [1]. Crystal data show that the packing is unique, and show the basis for the crystal's twinned growth. Twinning is a common and often serious problem in protein structure determination by x-ray crystallography [2]. In the present case the twinning is due to a small deviation (about 0.3 nm) from 4-fold symmetry in the primary intermolecular interface. The deviation produces pseudosymmetry, generating slightly different conformations of the protein, and alternating strong and weak forms of key packing interfaces throughout the lattice.

Pulse

MedlinePlus

... to take your wrist pulse References Bernstein D. History and physical examination. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Effect of one-year water storage on the surface microhardness of resin-modified versus conventional glass-ionomer cements.

PubMed

Ellakuria, J; Triana, R; Mínguez, N; Soler, I; Ibaseta, G; Maza, J; García-Godoy, F

2003-06-01

Conventional and resin-modified glass-ionomer cements (GIC, RM-GIC) are available for clinical use as restorative materials or as liners and bases. This study was conducted to compare the effect of a 12-month storage period in water on the surface microhardness, measured in Vickers units (VH), between a GIC and a RM-GIC group and to determine if the addition of resins improved the GIC microhardness. VH microhardness was assessed in three GIC: Ketac-Fil, Ketac-Molar and Ketac-Silver (KF, KM, KS) and three RM-GIC: Photac-Fil, Fuji II LC and Vitremer (PF, FU, VI) stored in distilled water at 37 degrees C for 12 months. Measurements were taken at 1, 7, 15, 30, 90, 180 and 365 days. The statistical evaluation was done by means of one-way analysis of variance (ANOVA) and Tukey's multiple comparison tests. There are significant VH differences among the materials studied and within each material over storage time. GICs, except for KS, showed a higher VH throughout the study period. Among the RM-GIC, VI showed a significantly higher VH at 12 months than at 1 day. The VH of PF diminished in the final stage of the study, whereas that of FU stabilized. The results suggest that the addition of resins to the GIC did not appear to improve the surface microhardness of these materials. Furthermore, the surface microhardness of both the conventional and resin-modified glass-ionomers suffered variations over time. However, these materials should not be deemed inadequate for use in clinical applications. Probably, conventional and resin-modified GICs placed in the oral environment would not be affected to the same extent as in in vitro tests.

The determination of water in crude oil and transformer oil reference materials.

PubMed

Margolis, Sam A; Hagwood, Charles

2003-05-01

The measurement of the amount of water in oils is of significant economic importance to the industrial community, particularly to the electric power and crude oil industries. The amount of water in transformer oils is critical to their normal function and the amount of water in crude oils affects the cost of the crude oil at the well head, the pipeline, and the refinery. Water in oil Certified Reference Materials (CRM) are essential for the accurate calibration of instruments that are used by these industries. Three NIST Standard Reference Materials (SRMs) have been prepared for this purpose. The water in these oils has been measured by both coulometric and volumetric Karl Fischer methods. The compounds (such as sulfur compounds) that interfere with the Karl Fischer reaction (interfering substances) and inflate the values for water by also reacting with iodine have been measured coulometrically. The measured water content of Reference Material (RM) 8506a Transformer Oil is 12.1+/-1.9 mg kg(-1) (plus an additional 6.2+/-0.9 mg kg(-1) of interfering substances). The measured water content of SRM 2722 Sweet Crude Oil, is 99+/-6 mg kg(-1) (plus an additional 5+/-2 mg kg(-1) of interfering substances). The measured water content of SRM 2721 Sour Crude Oil, is 134+/-18 mg kg(-1) plus an additional 807+/-43 mg kg(-1) of interfering substances. Interlaboratory studies conducted with these oil samples (using SRM 2890, water saturated 1-octanol, as a calibrant) are reported. Some of the possible sources of bias in these measurements were identified, These include: improperly calibrated instruments, inability to measure the calibrant accurately, Karl Fischer reagent selection, and volatilization of the interfering substances in SRM 2721.

Characterizing a Full Spectrum of Physico-Chemical Properties of Ginsenosides Rb1 and Rg1 to Be Proposed as Standard Reference Materials

PubMed Central

Kim, Il-Woung; Hong, Hee-Do; Choi, Sang Yoon; Hwang, Da-Hye; Her, Youl; Kim, Si-Kwan

2011-01-01

Good manufacturing practice (GMP)-based quality control is an integral component of the common technical document, a formal documentation process for applying a marketing authorization holder to those countries where ginseng is classified as a medicine. In addition, authentication of the physico-chemical properties of ginsenoside reference materials, and qualitative and quantitative batch analytical data based on validated analytical procedures are prerequisites for certifying GMP. Therefore, the aim of this study was to propose an authentication process for isolated ginsenosides Rb1 and Rg1 as reference materials (RM) and for these compounds to be designated as RMs for ginseng preparations throughout the world. Ginsenoside Rb1 and Rg1 were isolated by Diaion HP-20 adsorption chromatography, silica gel flash chromatography, recrystallization, and preparative HPLC. HPLC fractions corresponding to those two ginsenosides were recrystallized in appropriate solvents for the analysis of physico-chemical properties. Documentation of the isolated ginsenosides was made according to the method proposed by Gaedcke and Steinhoff. The ginsenosides were subjected to analyses of their general characteristics, identification, purity, content quantitation, and mass balance tests. The isolated ginsenosides were proven to be a single compound when analyzed by three different HPLC systems. Also, the water content was found to be 0.940% for Rb1 and 0.485% for Rg1, meaning that the net mass balance for ginsenoside Rb1 and Rg1 were 99.060% and 99.515%, respectively. From these results, we could assess and propose a full spectrum of physicochemical properties for the ginsenosides Rb1 and Rg1 as standard reference materials for GMP-based quality control. PMID:23717096

Meatal stenosis

MedlinePlus

... clean and dry. Avoid exposing the newly circumcised penis to any irritants. They may cause inflammation and ... Meatal stenosis References Elder JS. Anomalies of the penis and urethra. In: Kliegman RM, Stanton BF, St. ...

Performance of health product risk management and surveillance conducted by health personnel at sub-district health promotion hospitals in the northeast region of Thailand.

PubMed

Kanjanarach, Tipaporn; Jaisa-Ard, Raksaworn; Poonaovarat, Nantawan

2014-01-01

Health personnel at sub-district health promotion hospitals (SD-HPHs) are assigned to take responsibility for 15 activities related to health product risk management and surveillance (HP-RM&S). This cross-sectional survey aimed to identify factors that determined their job performance and to record their expressed needs to support HP-RM&S operation. In this study, job performance was defined as completion of all 15 activities. Self-administered postal questionnaires were used to collect data from 380 randomly selected health personnel who were in charge of HP-RM&S at SD-HPHs in the northeast of Thailand. Thirty-six point one percent (n=137) of the respondents were able to perform all 15 of the HP-RM&S activities assigned to SD-HPHs. A logistic regression model identified three factors that statistically significantly determined the completion of all 15 HP-RM&S activities. These were: receiving a high or very high level of support from the community (adjusted odds ratio [OR]: 2.5; 95% confidence interval [CI]: 1.5, 4.1), the responsible persons for HP-RM&S did not hold an administrative position (adjusted OR: 1.7; 95% CI: 1.1, 2.7), and having at least one training session related to HP-RM&S per year (adjusted OR: 1.7; 95% CI 1.1, 2.6). There were 1,536 expressed needs which can be classified into four major categories, ie, training needs (41.6%, n=639), resource support (28.3%, n=435), mechanisms that facilitate HP-RM&S operation (24.1%, n=370) and adjusting of the scope of HP-RM&S (6.0%, n=92). The topics most frequently referred to in training needs were drug law, food law, and cosmetics law. A strategy for improvement of the job performance in HP-RM&S of health personnel in SD-HPHs should target identifying schemes to encourage the community to proactively participate in HP-RM&S. The district health office as the organization directly controlling and supervising SD-HPHs should also regularly update knowledge base and skills necessary for HP-RM&S operation through training of the responsible health personnel.

Using growth and arrest of Richtmyer-Meshkov instabilities and Lagrangian simulations to study high-rate material strength

NASA Astrophysics Data System (ADS)

Prime, M. B.; Vaughan, D. E.; Preston, D. L.; Buttler, W. T.; Chen, S. R.; Oró, D. M.; Pack, C.

2014-05-01

Experiments applying a supported shock through mating surfaces (Atwood number = 1) with geometrical perturbations have been proposed for studying strength at strain rates up to 107/s using Richtmyer-Meshkov (RM) instabilities. Buttler et al. recently reported experimental results for RM instability growth in copper but with an unsupported shock applied by high explosives and the geometrical perturbations on the opposite free surface (Atwood number = -1). This novel configuration allowed detailed experimental observation of the instability growth and arrest. We present results and interpretation from numerical simulations of the Buttler RM instability experiments. Highly-resolved, two-dimensional simulations were performed using a Lagrangian hydrocode and the Preston-Tonks-Wallace (PTW) strength model. The model predictions show good agreement with the data. The numerical simulations are used to examine various assumptions previously made in an analytical model and to estimate the sensitivity of such experiments to material strength.

Studies of High Critical Transition Temperature Superconductors

NASA Astrophysics Data System (ADS)

Zhou, Xue Zhi

1990-01-01

In early 1987 the high-T_{ rm c} superconductor, YBa_2 Cu_3O_{7 -delta}, with T_{ rm c} ~eq 90K was successfully made in our laboratory by a standard ceramic technique. Later Tl_2Ca _2Ba_2Cu_3 O_{10} with T _{rm c} ~eq 120K was produced by a special procedure. Structural analysis by x-ray diffraction showed that YBa_2 Cu_3O_{7 -delta} was responsible for the high -T_{rm c}, the so called 123 phase. It is an oxygen deficient perovskite with the orthorhombic structure, space group Pmmm, lattice constant a = 3.8243, b = 3.8862 and c = 11.667 A. Oxygen vacancies are very important to the superconducting properties. An impurity, Y_2BaCuO_5 , with a green colour, was identified as a semiconducting phase. A technique to grow single crystals of YBa _2Cu_3O_ {7-delta} is described. The crystals are rectangular up to 2 x 2 x 0.2 mm^3 in size. Two phases, Tl_2CaBa _2Cu_2O_8 (the 2122 phase) and Tl_2Ca _2Ba_2Cu _3O_{10} (the 2223 phase), are responsible for the high-T _{rm c} in the Tl-system; they have a tetragonal or pseudotetragonal structure with space group I4/mmm. Resistivity and magnetic ac susceptibility results show that high-T_{rm c} materials have a sharp superconducting transition and many properties in common with conventional superconductors. The shielding effect is closely related to the properties of grain boundaries. Magnetic ordering at low temperature (below 10K) of high-T_{rm c} materials was discovered by Mossbauer experiments with ^{57}Fe doped samples. Substitution of Fe for Cu reduced the superconducting transition temperature and the shielding effect. Theories of superconductivity for conventional and the new superconductors are reviewed and related to the experimental results.

Reference Management Software: A Comparative Analysis of Four Products

ERIC Educational Resources Information Center

Gilmour, Ron; Cobus-Kuo, Laura

2011-01-01

Reference management (RM) software is widely used by researchers in the health and natural sciences. Librarians are often called upon to provide support for these products. The present study compares four prominent RMs: CiteULike, RefWorks, Mendeley, and Zotero, in terms of features offered and the accuracy of the bibliographies that they…

76 FR 72005 - NUREG-1556, Volume 2, Revision 1, “Consolidated Guidance About Materials Licenses Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

... instructions on submitting comments and instructions on accessing documents related to this action, see.../reading-rm/adams.html . From this page, the public can gain entry into ADAMS, which provides text and... site: The document will also be posted on NRC's public Web Site at: (1) http://www.nrc.gov/reading-rm...

Herpangina

MedlinePlus

... lead to this infection. Images Throat anatomy Mouth anatomy References Abzug MJ. Nonpolio enteroviruses. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Gunshot wounds -- aftercare

MedlinePlus

... wound References Simon BC, Hern HG. Wound management principles. In: Marx JA, Hockberger RS, Walls RM, et ... member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www. ...

Arachnodactyly

MedlinePlus

... an underlying disorder. Causes Causes may include: Homocystinuria Marfan syndrome Other rare genetic disorders Note: Having long, slender ... Achromachia References Doyle Al, Doyle JJ, Dietz HC. Marfan syndrome. In: Kliegman RM, Stanton BF, St. Geme JW, ...

Workshop on standards in biomass for energy and chemicals: proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milne, T.A.

1984-11-01

In the course of reviewing standards literature, visiting prominent laboratories and research groups, attending biomass meetings and corresponding widely, a whole set of standards needs was identified, the most prominent of which were: biomass standard reference materials, research materials and sample banks; special collections of microorganisms, clonal material, algae, etc.; standard methods of characterization of substrates and biomass fuels; standard tests and methods for the conversion and end-use of biomass; standard protocols for the description, harvesting, preparation, storage, and measurement of productivity of biomass materials in the energy context; glossaries of terms; development of special tests for assay of enzymaticmore » activity and related processes. There was also a recognition of the need for government, professional and industry support of concensus standards development and the dissemination of information on standards. Some 45 biomass researchers and managers met with key NBS staff to identify and prioritize standards needs. This was done through three working panels: the Panel on Standard Reference Materials (SRM's), Research Materials (RM's), and Sample Banks; the Panel on Production and Characterization; and the Panel on Tests and Methods for Conversion and End Use. This report gives a summary of the action items in standards development recommended unanimously by the workshop attendees. The proceedings of the workshop, and an appendix, contain an extensive written record of the findings of the workshop panelists and others regarding presently existing standards and standards issues and needs. Separate abstracts have been prepared for selected papers for inclusion in the Energy Database.« less

Vomiting blood

MedlinePlus

... in the vomit References Goralnick E, Meguerdichian DA. Gastrointestinal bleeding. In: Marx JA, Hockberger RS, Walls RM, et ... Saunders; 2016:chap 135. Savides TJ, Jensen DM. Gastrointestinal bleeding. In: Feldman M, Friedman LS, Brandt LJ, eds. ...

Drop Calibration of Accelerometers for Shock Measurement

DTIC Science & Technology

2011-08-01

important that the screen is clear, the records displayed are crisp and values are easily read. The current DSO, used within the Division, in the...Capacitor ≤ ± 0.01% ξc Tolerance of capacitor Drop Mass Reading ≤ ± 0.083 %  dm 0.1g over 120g (typically) Reference Mass Reading ≤ ± 0.1 % rm...Therefore m has uncertainty components due to rm ,  dm and ξrme. The random component is  222 dmrmm  (6.8) and once again  dsodc

Nanoscale reference materials for environmental, health and safety measurements: needs, gaps and opportunities.

PubMed

Stefaniak, Aleksandr B; Hackley, Vincent A; Roebben, Gert; Ehara, Kensei; Hankin, Steve; Postek, Michael T; Lynch, Iseult; Fu, Wei-En; Linsinger, Thomas P J; Thünemann, Andreas F

2013-12-01

The authors critically reviewed published lists of nano-objects and their physico-chemical properties deemed important for risk assessment and discussed metrological challenges associated with the development of nanoscale reference materials (RMs). Five lists were identified that contained 25 (classes of) nano-objects; only four (gold, silicon dioxide, silver, titanium dioxide) appeared on all lists. Twenty-three properties were identified for characterisation; only (specific) surface area appeared on all lists. The key themes that emerged from this review were: 1) various groups have prioritised nano-objects for development as "candidate RMs" with limited consensus; 2) a lack of harmonised terminology hinders accurate description of many nano-object properties; 3) many properties identified for characterisation are ill-defined or qualitative and hence are not metrologically traceable; 4) standardised protocols are critically needed for characterisation of nano-objects as delivered in relevant media and as administered to toxicological models; 5) the measurement processes being used to characterise a nano-object must be understood because instruments may measure a given sample in a different way; 6) appropriate RMs should be used for both accurate instrument calibration and for more general testing purposes (e.g., protocol validation); 7) there is a need to clarify that where RMs are not available, if "(representative) test materials" that lack reference or certified values may be useful for toxicology testing and 8) there is a need for consensus building within the nanotechnology and environmental, health and safety communities to prioritise RM needs and better define the required properties and (physical or chemical) forms of the candidate materials.

Respiratory morbidity among welders in the shipbuilding industry, Goa

PubMed Central

Bhumika, Nateshan; Prabhu, Ganapati Vasant; Ferreira, Agnelo Menino; Kulkarni, Manoj Kumar; Vaz, Frederick Satiro; Singh, Zile

2012-01-01

Context: Welding is pivotal in shipbuilding. The fumes and gases involved in welding may cause respiratory morbidity. Aim: To study the prevalence of respiratory morbidity (RM) among welders vis à vis among nonwelders and its association with certain relevant factors. Settings and Design: A cross-sectional study of 276 welders and 276 nonwelders was conducted in the shipbuilding industry. Materials and Methods: An interviewer-administered questionnaire was followed by spirometric examination. Statistical Analysis: Odds ratio and its 95% CI and two-way ANOVA. Results: Prevalence of RM was found to be significantly higher among welders compared to nonwelders (who were comparable in age, duration of employment (DOE) and smoking habits,) with odds ratio (OR) of 1.78 (95% confidence interval (CI):1.20-2.63). Obstructive type of RM was predominant in both welders (26% (n = 73)) and nonwelders (17% (n = 49)) with welders being at a significantly higher risk (OR = 1.66 (95%: 1.10-2.49)). RM was commoner after the 40 years of age or after 20 years of employment in both groups. Smoking was associated with RM among welders (OR = 1.48, 95% CI: 1.24-1.75) as well as nonwelders (OR = 2.83, 95% CI: 2.26-3.54). Work-related respiratory symptoms (WRRS) was not found to be related to RM (OR = 1.69, 95% CI: 1.00-2.84). Consistent use of personal protective equipment (PPE) was protective against RM in welders (OR = 0.33, 95% CI: 0.28-0.37). Conclusion: Welders had a greater burden of RM and this was related to increasing age, DOE, smoking and inconsistent use of PPE. WRRS were not indicative of RM. PMID:23580835

Enlarged adenoids

MedlinePlus

... Instructions Tonsil and adenoid removal - discharge Images Throat anatomy Adenoids References Wetmore RF. Tonsils and adenoids. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Eustachian tube patency

MedlinePlus

... to become blocked. Images Ear anatomy Eustachian tube anatomy References Kerschner JE, Preciado D. Otitis media. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Paraphimosis

MedlinePlus

... done correctly, prevents this condition. Images Male reproductive anatomy References Elder JS. Anomalies of the penis and urethra. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Penis

MedlinePlus

... Ambiguous genitalia Penile prosthesis Priapism Images Male reproductive anatomy References Elder JS. Anomalies of the penis and urethra. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Genetics Home Reference: mycosis fungoides

MedlinePlus

... Cigudosa JC, Barranco C, Serrano S, Dummer R, Tensen CP, Solé F, Pujol RM, Espinet B. Oligonucleotide array- ... K, Knijnenburg J, Boer JM, Willemze R, Tensen CP. Oncogenomic analysis of mycosis fungoides reveals major differences ...

[Characteristics and mechanism of sodium removal by the synergistic action of flue gas and waste solid].

PubMed

Yi, Yuan-Rong; Han, Min-Fang

2012-07-01

The carbon dioxide (CO2) in flue gas was used to remove the sodium in the red mud (RM) , a kind of alkaline solid waste generated during alumina production. The reaction characteristics and mechanism of sodium removal by the synergistic action of CO2 and RM were studied with different medium pH, reaction time and temperature. It was demonstrated that the remove of sodium by RM was actually the result of the synergistic action of sodium-based solid waste in RM with the CO2-H2O and OH(-)-CO2 systems. The sodium removal efficiency was correlated with pH, reaction temperature and time. The characteristics of RM before and after sodium removal were analyzed using X-ray diffractometer (XRD) and scanning electron microscope (SEM), and the results showed that the alkaline materials in the red mud reacted with CO2 and the sodium content in solid phases decreased significantly after reaction. The sodium removal efficiency could reach up to 70% with scientific procedure. The results of this research will offer an efficient way for low-cost sodium removal.

Scrotal swelling

MedlinePlus

... of the scrotum; Testicular enlargement Images Male reproductive anatomy References Elder JS. Disorders and anomalies of the scrotal contents. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Allergic rhinitis - what to ask your doctor - child

MedlinePlus

... child References Baroody FM, Naclerio RM. Allergy and immunology of the upper airway. In: Flint PW, Haughey ... D.A.M. Editorial team. Related MedlinePlus Health Topics Allergy Hay Fever Browse the Encyclopedia A.D. ...

Uncertainty Analysis in the Creation of a Fine-Resolution Leaf Area Index (LAI) Reference Map for Validation of Moderate Resolution LAI Products

EPA Science Inventory

The validation process for a moderate resolution leaf area index (LAI) product (i.e., MODIS) involves the creation of a high spatial resolution LAI reference map (Lai-RM), which when scaled to the moderate LAI resolution (i.e., >1 km) allows for comparison and analysis with this ...

Comparative physicochemical and biological characterization of NIST Interim Reference Material PM2.5 and SRM 1648 in human A549 and mouse RAW264.7 cells.

PubMed

Mitkus, Robert J; Powell, Jan L; Zeisler, Rolf; Squibb, Katherine S

2013-12-01

The epidemiological association between exposure to fine particulate matter (PM2.5) and adverse health effects is well-known. Here we report the size distribution, metals content, endotoxin content, and biological activity of National Institute of Standards and Technology (NIST) Interim Reference Material (RM) PM2.5. Biological activity was measured in vitro by effects on cell viability and the release of four inflammatory immune mediators, from human A549 alveolar epithelial cells or murine RAW264.7 monocytes. A dose range covering three orders of magnitude (1-1000μg/mL) was tested, and biological activity was compared to an existing Standard Reference Material (SRM) for urban PM (NIST SRM 1648). Robust release of IL-8 and MCP-1 from A549 cells was observed in response to IRM PM2.5 exposures. Significant TNF-α, but not IL-6, secretion from RAW264.7 cells was observed in response to both IRM PM2.5 and SRM 1648 particle types. Cytokine or chemokine release at high doses often occurred in the presence of cytotoxicity, likely as a result of externalization of preformed mediator. Our results are consistent with a local cytotoxic and pro-inflammatory mechanism of response to exposure to inhaled ambient PM2.5 and reinforce the continued relevance of in vitro assays for mechanistic research in PM toxicology. Our study furthers the goal of developing reference samples of environmentally relevant particulate matter of various sizes that can be used for hypothesis testing by multiple investigators. Published by Elsevier Ltd.

Testicular biopsy

MedlinePlus

... Names Biopsy - testicle Images Endocrine glands Male reproductive anatomy Testicular biopsy References Garibaldi LR, Chematilly W. Disorders of pubertal development. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Discrete Event Simulation-Based Resource Modelling in Health Technology Assessment.

PubMed

Salleh, Syed; Thokala, Praveen; Brennan, Alan; Hughes, Ruby; Dixon, Simon

2017-10-01

The objective of this article was to conduct a systematic review of published research on the use of discrete event simulation (DES) for resource modelling (RM) in health technology assessment (HTA). RM is broadly defined as incorporating and measuring effects of constraints on physical resources (e.g. beds, doctors, nurses) in HTA models. Systematic literature searches were conducted in academic databases (JSTOR, SAGE, SPRINGER, SCOPUS, IEEE, Science Direct, PubMed, EMBASE) and grey literature (Google Scholar, NHS journal library), enhanced by manual searchers (i.e. reference list checking, citation searching and hand-searching techniques). The search strategy yielded 4117 potentially relevant citations. Following the screening and manual searches, ten articles were included. Reviewing these articles provided insights into the applications of RM: firstly, different types of economic analyses, model settings, RM and cost-effectiveness analysis (CEA) outcomes were identified. Secondly, variation in the characteristics of the constraints such as types and nature of constraints and sources of data for the constraints were identified. Thirdly, it was found that including the effects of constraints caused the CEA results to change in these articles. The review found that DES proved to be an effective technique for RM but there were only a small number of studies applied in HTA. However, these studies showed the important consequences of modelling physical constraints and point to the need for a framework to be developed to guide future applications of this approach.

The Drug Safety and Risk Management Advisory Committee: a case study of meeting frequency, content, and outcomes before and after FDAAA.

PubMed

Morrato, Elaine H; Ling, Sarah B

2012-11-01

The Food and Drug Administration Amendments Act (FDAAA) of 2007 granted FDA-expanded drug safety authority. We hypothesized that meetings involving the FDA Drug Safety and Risk Management (DSaRM) Advisory Committee might serve as a barometer for the impact of FDAAA on drug safety regulatory decision making. We conducted a case study analysis of 42 DSaRM advisory committee meetings held between 2002 and 2011. Publicly available sources (FDA meeting minutes and materials, safety alerts, and drug manufacturer Web sites) were reviewed to describe and compare DSaRM meeting frequency, content and outcomes between the pre-FDAAA (2002-2007) and post-FDAAA (2008-2011) periods. DSaRM meeting frequency increased after FDAAA (from 2.7 to 6.5 meetings per year). DSaRM meetings were more likely to be held jointly with other drug advisory committees after FDAAA (from 68% to 92% of meetings). DSaRM members were invited participants in 35 additional meetings of other drug advisory committees (2007-2011). DSaRM meetings were more likely to review issues of approvability (eg, new drugs, new indications, and new product formulations) after FDAAA. FDA questions to the committee were more likely to request an explicit drug safety assessment after FDAAA (from 31% to 76% of meetings). Content analysis of meeting outcomes and subsequent FDA regulatory decisions did not suggest a more or less risk aversive climate after FDAAA. Increased DSaRM advisory committee activity indicates its advice was being sought more broadly for drug regulatory decision making and at earlier stages of drug development after FDAAA was enacted.

Enhancing Energy in Future Conventional Munition

NASA Astrophysics Data System (ADS)

Peiris, Suhithi

2017-06-01

Future conventional weapons are envisioned to contain more energy per volume than current weapons. Current weapons comprise of inert steel outer case, with inner volume for energetic materials, fuzing, sensor package, propulsion system, etc. Recent research on reactive materials (RM) & new energetics, and exploiting additive manufacturing can optimize the use of both mass and volume to achieve much higher energy in future weapons. For instance, replacing inert steel with RM of similar strength, additively manufacturing fuzing packages within the weapon form factor, and combing the whole with new energetics, will enable the same lethality effects from smaller weapons as obtained from today's larger weapons. This paper will elaborate on reactive materials and properties necessary for optimal utilization in various weapon features, and touch on other aspects of enhancing energy in future conventional munition.

Converting Garbage to Gold: Recycling Our Materials.

ERIC Educational Resources Information Center

Chandler, William U.

1984-01-01

Recycling conserves energy, fights pollution and inflation, creates jobs, and improves the outlook for the future of materials. But converting a throwaway society to recycling will depend on finding good markets for waste paper and scrap metals. (RM)

Curvature of the penis

MedlinePlus

... penis. Alternative Names Peyronie disease Images Male reproductive anatomy Male reproductive system References Elder JS. Anomalies of the penis and urethra. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016: ...

Detecting Deception in 1984.

ERIC Educational Resources Information Center

Lykken, David T.

1984-01-01

Reviews in contemporary detail, but without reference to Orwell's book "1984," a problem that plagued the Inner Party and its Thought Police: "how to discover, against his will, what another human being is thinking." Polygraph tests and lie detectors are discussed. (RM)

Effect of G-Coat Plus on the mechanical properties of glass-ionomer cements.

PubMed

Bagheri, R; Taha, N A; Azar, M R; Burrow, M F

2013-12-01

Although various mechanical properties of tooth-coloured materials have been described, little data have been published on the effect of ageing and G-Coat Plus on the hardness and strength of the glass-ionomer cements (GICs). Specimens were prepared from one polyacid-modified resin composite (PAMRC; Freedom, SDI), one resin-modified glass-ionomer cement; (RM-GIC; Fuji II LC, GC), and one conventional glass-ionomer cement; (GIC; Fuji IX, GC). GIC and RM-GIC were tested both with and without applying G-Coat Plus (GC). Specimens were conditioned in 37 °C distilled water for either 24 hours, four and eight weeks. Half the specimens were subjected to a shear punch test using a universal testing machine; the remaining half was subjected to Vickers Hardness test. Data analysis showed that the hardness and shear punch values were material dependent. The hardness and shear punch of the PAMRC was the highest and GIC the lowest. Applying the G-Coat Plus was associated with a significant decrease in the hardness of the materials but increase in the shear punch strength after four and eight weeks. The mechanical properties of the restorative materials were affected by applying G-Coat Plus and distilled water immersion over time. The PAMRC was significantly stronger and harder than the RM-GIC or GIC. © 2013 Australian Dental Association.

Arsenic sorption by red mud-modified biochar produced from rice straw.

PubMed

Wu, Chuan; Huang, Liu; Xue, Sheng-Guo; Huang, Yu-Ying; Hartley, William; Cui, Meng-Qian; Wong, Ming-Hung

2017-08-01

Red mud-modified biochar (RM-BC) has been produced to be utilized as a novel adsorbent to remove As because it can effectively combine the beneficial features of red mud (rich metal oxide composition and porous structure) and biochar (large surface area and porous structure properties). SEM-EDS and XRD analyses demonstrated that red mud had loaded successfully on the surface of biochar. With the increasing of pH in solution, arsenate (As(V)) adsorption on RM-BC decreased while arsenite (As(III)) increased. Arsenate adsorption kinetics process on RM-BC fitted the pseudo-second-order model, while that of As(III) favored the Elovich model. All sorption isotherms produced superior fits with the Langmuir model. RM-BC exhibited improved As removal capabilities, with a maximum adsorption capacity (Q max ) for As(V) of 5923 μg g -1 , approximately ten times greater than that of the untreated BC (552.0 μg g -1 ). Furthermore, it has been indicated that the adsorption of As(V) on RM-BC may be strongly associated with iron oxides (hematite and magnetite) and aluminum oxides (gibbsite) by X-ray absorption near-edge spectroscopy (XANES), which was possibly because of surface complexation and electrostatic interactions. RM-BC may be used as a valuable adsorbent for removing As in the environment due to the waste materials being relatively abundant.

Population Structure, Genetic Diversity and Molecular Marker-Trait Association Analysis for High Temperature Stress Tolerance in Rice

PubMed Central

Barik, Saumya Ranjan; Sahoo, Ambika; Mohapatra, Sudipti; Nayak, Deepak Kumar; Mahender, Anumalla; Meher, Jitandriya; Anandan, Annamalai

2016-01-01

Rice exhibits enormous genetic diversity, population structure and molecular marker-traits associated with abiotic stress tolerance to high temperature stress. A set of breeding lines and landraces representing 240 germplasm lines were studied. Based on spikelet fertility percent under high temperature, tolerant genotypes were broadly classified into four classes. Genetic diversity indicated a moderate level of genetic base of the population for the trait studied. Wright’s F statistic estimates showed a deviation of Hardy-Weinberg expectation in the population. The analysis of molecular variance revealed 25 percent variation between population, 61 percent among individuals and 14 percent within individuals in the set. The STRUCTURE analysis categorized the entire population into three sub-populations and suggested that most of the landraces in each sub-population had a common primary ancestor with few admix individuals. The composition of materials in the panel showed the presence of many QTLs representing the entire genome for the expression of tolerance. The strongly associated marker RM547 tagged with spikelet fertility under stress and the markers like RM228, RM205, RM247, RM242, INDEL3 and RM314 indirectly controlling the high temperature stress tolerance were detected through both mixed linear model and general linear model TASSEL analysis. These markers can be deployed as a resource for marker-assisted breeding program of high temperature stress tolerance. PMID:27494320

Cr(VI) Adsorption on Red Mud Modified by Lanthanum: Performance, Kinetics and Mechanisms

PubMed Central

Cui, You-Wei; Li, Jie; Du, Zhao-Fu; Peng, Yong-Zhen

2016-01-01

Water pollution caused by the highly toxic metal hexavalent chromium (Cr(VI)) creates significant human health and ecological risks. In this study, a novel adsorbent was used to treat Cr(VI)-containing wastewater; the adsorbent was prepared using red mud (RM) generated from the alumina production industry and the rare earth element lanthanum. This study explored adsorption performance, kinetics, and mechanisms. Results showed that the adsorption kinetics of the RM modified by lanthanum (La-RM), followed the pseudo-second-order model, with a rapid adsorption rate. Cr(VI) adsorption was positively associated with the absorbent dose, pH, temperature, and initial Cr(VI) concentration; coexisting anions had little impact. The maximum Cr(VI) adsorption capacity was 17.35 mg/g. Cr(VI) adsorption on La-RM was a mono-layer adsorption pattern, following the Langmuir isotherm model. Thermodynamic parameters showed the adsorption was spontaneous and endothermic. The adsorption of Cr(VI) on La-RM occurred as a result of LaOCl formation on the RM surface, which in turn further reacted with Cr(VI) in the wastewater. This study highlighted a method for converting industrial waste into a valuable material for wastewater treatment. The novel absorbent could be used as a potential adsorbent for treating Cr(VI)-contaminating wastewater, due to its cost-effectiveness and high adsorption capability. PMID:27658113

Population Structure, Genetic Diversity and Molecular Marker-Trait Association Analysis for High Temperature Stress Tolerance in Rice.

PubMed

Pradhan, Sharat Kumar; Barik, Saumya Ranjan; Sahoo, Ambika; Mohapatra, Sudipti; Nayak, Deepak Kumar; Mahender, Anumalla; Meher, Jitandriya; Anandan, Annamalai; Pandit, Elssa

2016-01-01

Rice exhibits enormous genetic diversity, population structure and molecular marker-traits associated with abiotic stress tolerance to high temperature stress. A set of breeding lines and landraces representing 240 germplasm lines were studied. Based on spikelet fertility percent under high temperature, tolerant genotypes were broadly classified into four classes. Genetic diversity indicated a moderate level of genetic base of the population for the trait studied. Wright's F statistic estimates showed a deviation of Hardy-Weinberg expectation in the population. The analysis of molecular variance revealed 25 percent variation between population, 61 percent among individuals and 14 percent within individuals in the set. The STRUCTURE analysis categorized the entire population into three sub-populations and suggested that most of the landraces in each sub-population had a common primary ancestor with few admix individuals. The composition of materials in the panel showed the presence of many QTLs representing the entire genome for the expression of tolerance. The strongly associated marker RM547 tagged with spikelet fertility under stress and the markers like RM228, RM205, RM247, RM242, INDEL3 and RM314 indirectly controlling the high temperature stress tolerance were detected through both mixed linear model and general linear model TASSEL analysis. These markers can be deployed as a resource for marker-assisted breeding program of high temperature stress tolerance.

Using the Richtmyer-Meshkov flow to infer the strength of LY-12 aluminum at extreme conditions

NASA Astrophysics Data System (ADS)

Yin, Jianwei; Pan, Hao; Peng, Jiangxiang; Wu, Zihui; Yu, Yuying; Hu, Xiaomian

2017-06-01

An improved analytical model of the Richtmyer-Meshkov (RM) flow in the elastoplastic materials is presented in this paper. This model describes the stabilization by yield strength (Y) effect on the RM flow in solids and linear relationships between initial configurations of perturbation and the growth. Then we make use of the model to analysis the explosion driven RM flow experiments with solid LY12 and test our model by comparing the predicted Y of existing strength models. Finally, we perform a plate impact experiment with solid LY12 aluminium alloy to validate our model and infer Y is about 1.23 GPa for a 28 GPa shock and a strain rate of 7.5 ×106 .

Microstructural Characterization of Red Mud as Affected by Inorganic and Organic Chemicals Permeation

NASA Astrophysics Data System (ADS)

Rubinos, David A.; Valcárcel, Víctor; Spagnoli, Giovanni; Barral, María Teresa

2017-09-01

The microstructural characteristics of red mud (RM), especially specific surface area (SSA) and mesoporosity, and the effects of various representative fluids, namely methanol (80% v/v), trichloroethylene (TCE) (1100 mg/L), acetic acid (pH 2), and CaCl2 (5% w/v) aqueous solutions, were studied using N2-gas adsorption. The effect of compaction was also assessed. RM powder exhibited a moderate Brunauer-Emmet-Teller (BET)-SSA and is mostly a mesoporous (large mesopores, 200-500 Å) and a macroporous material. Compaction affected the macro and large, but not the fine, mesopores. Among the fluids, CaCl2 and acetic acid induced notable and opposing changes in RM microstructural characteristics. CaCl2 decreased SSA and suppressed fine mesoporosity, whereas acetic acid greatly enhanced them. Fractal analysis further indicated increasing surface roughness and heterogeneity of pore structure during acid exposure, altogether envisaging an improvement of adsorption capacity and a decrease of permeability of the RM.

Frequency of null allele of Human Leukocyte Antigen-G (HLA-G) locus in subjects to recurrent miscarriage

PubMed Central

Alizadeh, Nazila; Mosaferi, Elnaz; Farzadi, Laya; Majidi, Jafar; Monfaredan, Amir; Yousefi, Bahman; Baradaran, Behzad

2016-01-01

Background: Human leukocyte antigen-G (HLA-G) is a non-classical class I molecule highly expressed by extravillous cytotrophoblast cells. Due to a single base pair deletion, its function can be compensated by other isoforms. Investigating the frequency of null allele in Recurrent Miscarriage (RM) subjects could be useful in understanding the relationship between frequency of this allele and RM in a given population. Objective: This study aimed to determine the frequency of HLA-G*0105N null allele and its potential association with down-regulation of HLA-G in subjects with RM. Materials and Methods: Western blotting was used to assess the level of HLA-G protein expression. For investigating the frequency of HLA-G*0105N null allele in RM subjects, PCR-RFLP method was used. Exon 3 of HLA-G gene was amplified by polymerase chain reaction (PCR). Subsequently, PpuM-1 enzyme was employed to digest the PCR products and fragments were analyzed using gel electrophoresis. Results: Digestion using restriction enzyme showed the presence of heterozygous HLA-G*0105N null allele in 10% of the test population. Western blotting results confirmed the decrease in expression of HLA-G in the placental tissue of subjects with RM compared to subjects who could give normal birth. Conclusion: The frequency of heterozygous HLA-G*0105N null allele was high to some extent in subjects with RM. The mutation rate in subjects suggested that there is a significant association between RM and frequency of mutations in this allele. PMID:27525330

THERMAL PLASMA IN THE GIANT LOBES OF THE RADIO GALAXY CENTAURUS A

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Sullivan, S. P.; Feain, I. J.; McClure-Griffiths, N. M.

2013-02-20

We present a Faraday rotation measure (RM) study of the diffuse, polarized, radio emission from the giant lobes of the nearest radio galaxy, Centaurus A. After removal of the smooth Galactic foreground RM component, using an ensemble of background source RMs located outside the giant lobes, we are left with a residual RM signal associated with the giant lobes. We find that the most likely origin of this residual RM is from thermal material mixed throughout the relativistic lobe plasma. The alternative possibility of a thin-skin/boundary layer of magnetoionic material swept up by the expansion of the lobes is highlymore » unlikely since it requires, at least, an order of magnitude enhancement of the swept-up gas over the expected intragroup density on these scales. Strong depolarization observed from 2.3 to 0.96 GHz also supports the presence of a significant amount of thermal gas within the lobes; although depolarization solely due to RM fluctuations in a foreground Faraday screen on scales smaller than the beam cannot be ruled out. Considering the internal Faraday rotation scenario, we find a thermal gas number density of {approx}10{sup -4} cm{sup -3}, implying a total gas mass of {approx}10{sup 10} M {sub Sun} within the lobes. The thermal pressure associated with this gas (with temperature kT {approx} 0.5 keV, obtained from recent X-ray results) is approximately equal to the non-thermal pressure, indicating that over the volume of the lobes, there is approximate equipartition between the thermal gas, radio-emitting electrons, and magnetic field (and potentially any relativistic protons present).« less

Experimental Investigation of Widespread Delamination Damage to Composite Materials Caused by Radiant Heating

DTIC Science & Technology

2013-06-30

Rev. E) 2002. 7. RM-3002 Bismaleimide (BMI) Prepreg , Product Information, Renegade Materials Corporation, Revision Date: 16-May-2012 KOA 16... prepregs /polyimide- prepregs . Renegade Materials Corporation Website, Accessed June 20, 2013. 9. Shen, C. and G.S. Springer, “Moisture Absorption and

Benefits of a Pharmacology Antimalarial Reference Standard and Proficiency Testing Program Provided by the Worldwide Antimalarial Resistance Network (WWARN)

PubMed Central

Lourens, Chris; Lindegardh, Niklas; Barnes, Karen I.; Guerin, Philippe J.; Sibley, Carol H.; White, Nicholas J.

2014-01-01

Comprehensive assessment of antimalarial drug resistance should include measurements of antimalarial blood or plasma concentrations in clinical trials and in individual assessments of treatment failure so that true resistance can be differentiated from inadequate drug exposure. Pharmacometric modeling is necessary to assess pharmacokinetic-pharmacodynamic relationships in different populations to optimize dosing. To accomplish both effectively and to allow comparison of data from different laboratories, it is essential that drug concentration measurement is accurate. Proficiency testing (PT) of laboratory procedures is necessary for verification of assay results. Within the Worldwide Antimalarial Resistance Network (WWARN), the goal of the quality assurance/quality control (QA/QC) program is to facilitate and sustain high-quality antimalarial assays. The QA/QC program consists of an international PT program for pharmacology laboratories and a reference material (RM) program for the provision of antimalarial drug standards, metabolites, and internal standards for laboratory use. The RM program currently distributes accurately weighed quantities of antimalarial drug standards, metabolites, and internal standards to 44 pharmacology, in vitro, and drug quality testing laboratories. The pharmacology PT program has sent samples to eight laboratories in four rounds of testing. WWARN technical experts have provided advice for correcting identified problems to improve performance of subsequent analysis and ultimately improved the quality of data. Many participants have demonstrated substantial improvements over subsequent rounds of PT. The WWARN QA/QC program has improved the quality and value of antimalarial drug measurement in laboratories globally. It is a model that has potential to be applied to strengthening laboratories more widely and improving the therapeutics of other infectious diseases. PMID:24777099

Interlaboratory Comparison of Magnetic Thin Film Measurements.

PubMed

da Silva, F C S; Wang, C M; Pappas, D P

2003-01-01

A potential low magnetic moment standard reference material (SRM) was studied in an interlaboratory comparison. The mean and the standard deviation of the saturation moment m s, the remanent moment m r, and the intrinsic coercivity H c of nine samples were extracted from hysteresis-loop measurements. Samples were measured by thirteen laboratories using inductive-field loopers, vibrating-sample magnetometers, alternating-gradient force magnetometers, and superconducting quantum-interference-device magnetometers. NiFe films on Si substrates had saturation moment measurements reproduced within 5 % variation among the laboratories. The results show that a good candidate for an SRM must have a highly square hysteresis loop (m r/m s > 90 %), H c ≈ 400 A·m(-1) (5 Oe), and m s ≈ 2 × 10(-7) A·m(2) (2 × 10(-4) emu).

Nitrogen Gas Field Ion Source (GFIS) Focused Ion Beam (FIB) Secondary Electron Imaging: A First Look.

PubMed

Schmidt, Marek E; Yasaka, Anto; Akabori, Masashi; Mizuta, Hiroshi

2017-08-01

The recent technological advance of the gas field ion source (GFIS) and its successful integration into systems has renewed the interest in the focused ion beam (FIB) technology. Due to the atomically small source size and the use of light ions, the limitations of the liquid metal ion source are solved as device dimensions are pushed further towards the single-digit nanometer size. Helium and neon ions are the most widely used, but a large portfolio of available ion species is desirable, to allow a wide range of applications. Among argon and hydrogen, $${\\rm N}_{2}^{{\\plus}} $$ ions offer unique characteristics due to their covalent bond and their use as dopant for various carbon-based materials including diamond. Here, we provide a first look at the $${\\rm N}_{2}^{{\\plus}} $$ GFIS-FIB enabled imaging of a large selection of microscopic structures, including gold on carbon test specimen, thin metal films on insulator and nanostructured carbon-based devices, which are among the most actively researched materials in the field of nanoelectronics. The results are compared with images acquired by He+ ions, and we show that $${\\rm N}_{2}^{{\\plus}} $$ GFIS-FIB can offer improved material contrast even at very low imaging dose and is more sensitive to the surface roughness.

The Study of High-Speed Surface Dynamics Using a Pulsed Proton Beam

NASA Astrophysics Data System (ADS)

Buttler, William; Stone, Benjamin; Oro, David; Dimonte, Guy; Preston, Dean; Cherne, Frank; Germann, Timothy; Terrones, Guillermo; Tupa, Dale

2011-06-01

Los Alamos National Laboratory is presently engaged in development and implementation of ejecta source term and transport models for integration into LANL hydrodynamic computer codes. Experimental support for the effort spans a broad array of activities, including ejecta source term measurements from machine roughened Sn surfaces shocked by HE or flyer plates. Because the underlying postulate for ejecta formation is that ejecta are characterized by Richtmyer-Meshkov instability (RMI) phenomena, a key element of the theory and modeling effort centers on validation and verification RMI experiments at the LANSCE Proton Radiography Facility (pRad) to compare with modeled ejecta measurements. Here we present experimental results used to define and validate a physics based ejecta model together with remarkable, unexpected results of Sn instability growth in vacuum and gasses, and Sn and Cu RM growth that reveals the sensitivity of the RM instability to the yield strength of the material, Cu. The motivation of this last subject, RM growth linked to material strength, is to probe the shock pressure regions over which ejecta begins to form. Presenter

A diagnostic algorithm to optimize data collection and interpretation of Ripple Maps in atrial tachycardias.

PubMed

Koa-Wing, Michael; Nakagawa, Hiroshi; Luther, Vishal; Jamil-Copley, Shahnaz; Linton, Nick; Sandler, Belinda; Qureshi, Norman; Peters, Nicholas S; Davies, D Wyn; Francis, Darrel P; Jackman, Warren; Kanagaratnam, Prapa

2015-11-15

Ripple Mapping (RM) is designed to overcome the limitations of existing isochronal 3D mapping systems by representing the intracardiac electrogram as a dynamic bar on a surface bipolar voltage map that changes in height according to the electrogram voltage-time relationship, relative to a fiduciary point. We tested the hypothesis that standard approaches to atrial tachycardia CARTO™ activation maps were inadequate for RM creation and interpretation. From the results, we aimed to develop an algorithm to optimize RMs for future prospective testing on a clinical RM platform. CARTO-XP™ activation maps from atrial tachycardia ablations were reviewed by two blinded assessors on an off-line RM workstation. Ripple Maps were graded according to a diagnostic confidence scale (Grade I - high confidence with clear pattern of activation through to Grade IV - non-diagnostic). The RM-based diagnoses were corroborated against the clinical diagnoses. 43 RMs from 14 patients were classified as Grade I (5 [11.5%]); Grade II (17 [39.5%]); Grade III (9 [21%]) and Grade IV (12 [28%]). Causes of low gradings/errors included the following: insufficient chamber point density; window-of-interest<100% of cycle length (CL); <95% tachycardia CL mapped; variability of CL and/or unstable fiducial reference marker; and suboptimal bar height and scar settings. A data collection and map interpretation algorithm has been developed to optimize Ripple Maps in atrial tachycardias. This algorithm requires prospective testing on a real-time clinical platform. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Publications - GMC 65 | Alaska Division of Geological & Geophysical Surveys

Science.gov Websites

DGGS GMC 65 Publication Details Title: X-ray diffraction clay analysis of Shell Western E & P Inc see our publication sales page for more information. Bibliographic Reference Shaver, R.M., 1986, X-ray

Evaluation of the accuracy of extraoral laboratory scanners with a single-tooth abutment model: A 3D analysis.

PubMed

Mandelli, Federico; Gherlone, Enrico; Gastaldi, Giorgio; Ferrari, Marco

2017-10-01

The aim of this study was to compare the accuracy of different laboratory scanners using a calibrated coordinate measuring machine as reference. A sand blasted titanium reference model (RM) was scanned with an industrial 3D scanner in order to obtain a reference digital model (dRM) that was saved in the standard tessellation format (.stl). RM was scanned ten times with each one of the tested scanners (GC Europe Aadva, Zfx Evolution, 3Shape D640, 3Shape D700, NobilMetal Sinergia, EGS DScan3, Open Technologies Concept Scan Top) and all the scans were exported in .stl format for the comparison. All files were imported in a dedicated software (Geomagic Qualify 2013). Accuracy was evaluated calculating trueness and precision. Trueness values (μm [95% confidence interval]) were: Aadva 7,7 [6,8-8,5]; Zfx Evolution 9,2 [8,6-9,8]; D640 18,1 [12,2-24,0]; D700 12,8 [12,4-13,3]; Sinergia 31,1 [26,3-35,9]; DScan3 15,6 [11,5-19,7]; Concept Scan Top 28,6 [25,6-31,6]. Differences between scanners were statistically significant (p<.0005). Precision values (μm [95% CI]) were: Aadva 4,0 [3,8-4,2]; Zfx Evolution 5,1 [4,4-5,9]; D640 12,7 [12,4-13,1]; D700 11,0 [10,7-11,3]; Sinergia 16,3 [15,0-17,5]; DScan3 9,5 [8,3-10,6]; Concept Scan Top 19,5 [19,1-19,8]. Differences between scanners were statistically significant (p<.0005). The use a standardized scanning procedure fabricating a titanium reference model is useful to compare trueness and precision of different laboratory scanners; two laboratory scanners (Aadva, Zfx Evolution) were significantly better that other tested scanners. Copyright © 2016 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

Optimization of parameters for semiempirical methods V: Modification of NDDO approximations and application to 70 elements

PubMed Central

2007-01-01

Several modifications that have been made to the NDDO core-core interaction term and to the method of parameter optimization are described. These changes have resulted in a more complete parameter optimization, called PM6, which has, in turn, allowed 70 elements to be parameterized. The average unsigned error (AUE) between calculated and reference heats of formation for 4,492 species was 8.0 kcal mol−1. For the subset of 1,373 compounds involving only the elements H, C, N, O, F, P, S, Cl, and Br, the PM6 AUE was 4.4 kcal mol−1. The equivalent AUE for other methods were: RM1: 5.0, B3LYP 6–31G*: 5.2, PM5: 5.7, PM3: 6.3, HF 6–31G*: 7.4, and AM1: 10.0 kcal mol−1. Several long-standing faults in AM1 and PM3 have been corrected and significant improvements have been made in the prediction of geometries. Figure Calculated structure of the complex ion [Ta6Cl12]2+ (footnote): Reference value in parenthesis Electronic supplementary material The online version of this article (doi:10.1007/s00894-007-0233-4) contains supplementary material, which is available to authorized users. PMID:17828561

Resource management as a key factor for sustainable urban planning.

PubMed

Agudelo-Vera, Claudia M; Mels, Adriaan R; Keesman, Karel J; Rijnaarts, Huub H M

2011-10-01

Due to fast urbanization and increasing living standards, the environmental sustainability of our global society becomes more and more questionable. In this historical review we investigate the role of resources management (RM) and urban planning (UP) and propose ways for integration in sustainable development (SD). RM follows the principle of circular causation, and we reflect on to what extent RM has been an element for urban planning. Since the existence of the first settlements, a close relationship between RM, urbanization and technological development has been present. RM followed the demand for urban resources like water, energy, and food. In history, RM has been fostered by innovation and technology developments and has driven population growth and urbanization. Recent massive resource demand, especially in relation to energy and material flows, has altered natural ecosystems and has resulted in environmental degradation. UP has developed separately in response to different questions. UP followed the demand for improved living conditions, often associated to safety, good manufacturing and trading conditions and appropriate sanitation and waste management. In history UP has been a developing research area, especially since the industrial era and the related strong urbanization at the end of the 18th century. UP responded to new emerging problems in urban areas and became increasingly complex. Nowadays, UP has to address many objectives that are often conflicting, including, the urban sustainability. Our current urban un-sustainability is rooted in massive resource consumption and waste production beyond natural limits, and the absence of flows from waste to resources. Therefore, sustainable urban development requires integration of RM into UP. We propose new ways to this integration. Copyright © 2011 Elsevier Ltd. All rights reserved.

Modified granulation of red mud by weak gelling and its application to stabilization of Pb.

PubMed

Luo, Hui-li; Huang, Sheng-sheng; Luo, Lin; Wu, Gen-yi; Liu, Yan

2012-08-15

This study presents a novel modification of red mud (RM) with cementitious materials by rotary drum granulation under partial hydration. Admixtures and surfactants were applied to improve the microspore structure of red mud-based granules in order to stabilize Pb steadily. Through XRD and SEM-EDS analyses, it was demonstrated that calcite, the main alkali in RM, was partially concreted and coated. Compared to pH 12.47 for RM, the lowest pH of the granules was 10.66 implying that the release of OH(-) from hydrolysis and decomposition was decreased. Based on stabilization of Pb, influence on soil properties and forming qualities, composition of the optimum granule PSP was determined as 5% cement, 5% gypsum, 1% rice straw, and 0.1% emulsifier OP-10. Within a 90 d remediation, immobilization of ionic Pb in a 500 mg kg(-1) Pb-contaminated artificial soil was 9.85 mg kg(-1) at day 30 with 5% PSP2 as substitute. Furthermore, the reverse increase diminished as the final concentration was 11.13 mg kg(-1) while it was 14.25 mg kg(-1) by RM. The increase of residual Pb was 122.61%, which was better than the 83.92% of RM. Particularly, the highest pH in mine soil was 11.09 at day 1 with RM, but the decrease of ionic Pb was 46.26%. Meanwhile, a significant deviation from the control soil zeta-potential lasted longer and the recovery was more difficult, as compared to the granules. Therefore, a granulated modification of RM is shown to be very important when aiming at steady release of OH(-) to improve the later stabilization of Pb. Copyright © 2012 Elsevier B.V. All rights reserved.

Effects of ray profile modeling on resolution recovery in clinical CT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofmann, Christian; Knaup, Michael; Kachelrieß, Marc, E-mail: marc.kachelriess@dkfz-heidelberg.de

2014-02-15

Purpose: Iterative image reconstruction gains more and more interest in clinical routine, as it promises to reduce image noise (and thereby patient dose), to reduce artifacts, or to improve spatial resolution. However, among vendors and researchers, there is no consensus of how to best achieve these goals. The authors are focusing on the aspect of geometric ray profile modeling, which is realized by some algorithms, while others model the ray as a straight line. The authors incorporate ray-modeling (RM) in nonregularized iterative reconstruction. That means, instead of using one simple single needle beam to represent the x-ray, the authors evaluatemore » the double integral of attenuation path length over the finite source distribution and the finite detector element size in the numerical forward projection. Our investigations aim at analyzing the resolution recovery (RR) effects of RM. Resolution recovery means that frequencies can be recovered beyond the resolution limit of the imaging system. In order to evaluate, whether clinical CT images can benefit from modeling the geometrical properties of each x-ray, the authors performed a 2D simulation study of a clinical CT fan-beam geometry that includes the precise modeling of these geometrical properties. Methods: All simulations and reconstructions are performed in native fan-beam geometry. A water phantom with resolution bar patterns and a Forbild thorax phantom with circular resolution patterns representing calcifications in the heart region are simulated. An FBP reconstruction with a Ram–Lak kernel is used as a reference reconstruction. The FBP is compared to iterative reconstruction techniques with and without RM: An ordered subsets convex (OSC) algorithm without any RM (OSC), an OSC where the forward projection is modeled concerning the finite focal spot and detector size (OSC-RM) and an OSC with RM and with a matched forward and backprojection pair (OSC-T-RM, T for transpose). In all cases, noise was matched to be able to focus on comparing spatial resolution. The authors use two different simulation settings. Both are based on the geometry of a typical clinical CT system (0.7 mm detector element size at isocenter, 1024 projections per rotation). Setting one has an exaggerated source width of 5.0 mm. Setting two has a realistically small source width of 0.5 mm. The authors also investigate the transition from setting one to two. To quantify image quality, the authors analyze line profiles through the resolution patterns to define a contrast factor (CF) for contrast-resolution plots, and the authors compare the normalized cross-correlation (NCC) with respect to the ground truth of the circular resolution patterns. To independently analyze whether RM is of advantage, the authors implemented several iterative reconstruction algorithms: The statistical iterative reconstruction algorithm OSC, the ordered subsets simultaneous algebraic reconstruction technique (OSSART) and another statistical iterative reconstruction algorithm, denoted with ordered subsets maximum likelihood (OSML) algorithm. All algorithms were implemented both without RM (denoted as OSC, OSSART, and OSML) and with RM (denoted as OSC-RM, OSSART-RM, and OSML-RM). Results: For the unrealistic case of a 5.0 mm focal spot the CF can be improved by a factor of two due to RM: the 4.2 LP/cm bar pattern, which is the first bar pattern that cannot be resolved without RM, can be easily resolved with RM. For the realistic case of a 0.5 mm focus, all results show approximately the same CF. The NCC shows no significant dependency on RM when the source width is smaller than 2.0 mm (as in clinical CT). From 2.0 mm to 5.0 mm focal spot size increasing improvements can be observed with RM. Conclusions: Geometric RM in iterative reconstruction helps improving spatial resolution, if the ray cross-section is significantly larger than the ray sampling distance. In clinical CT, however, the ray is not much thicker than the distance between neighboring ray centers, as the focal spot size is small and detector crosstalk is negligible, due to reflective coatings between detector elements. Therefore,RM appears not to be necessary in clinical CT to achieve resolution recovery.« less

Utilization of lime-dried sludge for eco-cement clinker production: effects of different feeding points.

PubMed

Cao, Haihua; Liu, Wei; Xu, Jingcheng; Liu, Jia; Huang, Juwen; Huang, Xiangfeng; Li, Guangming

2018-02-01

Co-processing lime-dried sludge (LDS) in cement kilns is an appropriate technique to solve the problem of LDS disposal and promote the sustainable development for cement industry. However, there were limited studies that investigated the effects of feeding points on product quality and cement kiln emissions. In this study, simulated experiments were conducted by dividing the feeding points into high-temperature zones (HTZs) and raw mill (RM). Cement quality and major cement kiln emission characteristics were comprehensively investigated. The results showed that in terms of burnability, compressive strength and microstructure, the optimum co-processing amount of LDS were 9 wt% when feeding at RM, while 6% when feeding at HTZs. Meanwhile, the organic emissions of RM samples were mainly low environmental risk compounds of amides and nitrogenous heterocyclic compounds. Inorganic gaseous pollutions of NO X and SO 2 , respectively, were 8.11 mg/g DS and 12.89 mg/g DS, compared with 7.61 mg/g DS and 4.44 mg/g DS for HTZs. However, all the cement kiln emissions concentration were still much lower than standard requirements. Overall, RM had a bigger LDS co-processing capacity and higher, but acceptable, cement kiln emissions. Feeding LDS via RM could dispose larger amounts of sludge and provide more alternative materials for cement manufacturing.

Microstructure and Dynamic Failure Properties of Freeze-Cast Materials for Thermobaric Warhead Cases

DTIC Science & Technology

2012-12-01

Function LLNL Lawrence Livermore National Laboratory PDF Probability Density Function PMMA Poly(Methyl Methacrylate) RM Reactive Materials SEM...FREEZE CAST MATERIALS Freeze casting technology combines compounds such as aluminum oxide and poly(methyl methacrylate) ( PMMA ) to develop a...Subsequently, the porous structure can be infiltrated with a variety of materials, such as a standard polymer like PMMA . This hybrid material is believed

Atomic-Scale Structure of the Tin DX Center and Other Related Defects in Aluminum Gallium Arsenide Semiconductors Using Moessbauer Spectroscopy.

NASA Astrophysics Data System (ADS)

Greco, Luigi Alessandro

The DX center in III-V alloys has limited the use of these materials for electronic devices since the defect acts as an electron trap. To be able to control or eliminate the DX center, its atomic scale structure should be understood. Mossbauer spectroscopy has proven to be a valuable technique in probing the atomic-scale structure of certain atomic species. The dopant studied here is ^{119}Sn. The thermal diffusion of Sn in Al_ {rm x}Ga_{rm 1-x }As using different temperatures, times, sample geometries and As_4 overpressures in evacuated and sealed fused silica ampoules was studied by x-ray diffraction (XRD), secondary ion mass spectroscopy and electrochemical capacitance versus voltage measurements. The AlGaAs surfaces decomposed into various Sn, Si, Ga and As oxides when an As_4 overpressure was introduced during annealing. However, annealing under ambient As_4 and furnace cooling eliminated surface decomposition although the Sn diffusion depth was less than that for a 0.5 atm As_4 overpressure. SiO_{rm x} and Si_{rm x }N_{rm y} RF-sputtered thin film capping layers deposited on AlGaAs were studied by XRD and Auger electron spectroscopy. For the annealed SiO_{rm x} films the AlGaAs surface was preserved, independent of the cooling technique used. Mossbauer spectroscopy was conducted on ^{rm 119m} Sn-implanted Al_ {rm x } Ga_{rm 1-x} As (x = 0.22 and 0.25) used for the source experiments and ^{119}Sn-doped Al _{rm x}Ga _{rm 1-x}As (x = 0.15, N _{rm Sn} ~2 times 10 ^{18} cm^{ -3}) for the absorber experiment. The source samples were capped with 120 nm of SiO_ {rm x} to preserve the surface during the systematic study of annealing temperature versus site occupation and electrical activation via Mossbauer spectroscopy at 76 K and 4 K in the dark and in the light (to observe persistent photoconductivity (PPC) due to the DX center). For all of the annealing conditions used the x = 0.22 sample showed little evidence of PPC possibly due to compensating defects and/or radiation-induced capture. After annealing the x = 0.25 sample at 1000^circC for 2 hours under a Ga + Al overpressure, evidence of PPC was found via Hall measurements but no effect was seen by Mossbauer suggesting radiation-induced capture and/or non-nearest-neighbor lattice relaxation. The Ga + Al overpressure also served to decrease the loss of Sn through the SiO _{rm x} film, possibly through the removal of Ga and Al vacancies. The x = 0.15 absorber showed a persistent 15-18% change in the electrical resistance (10% change in n) between the light and dark. However, the observation of this effect was not apparent, even assuming negative-U (2 electron) behavior, in the Mossbauer measurements. This was also consistent with EXAFS results. These studies do not support the broken-bond model of Chadi and Chang, which is considered to be a widely accepted atomic-scale model of the DX center. A defect complex consisting of a substitutional Sn_{rm Ga(Al) }^+ site, and a (V_{ rm III}^-Al_{ rm As}^{-2}) complex, which localizes 3 electrons and may not be a nearest-neighbor to the donor, was chosen for the DX center in the x = 0.15 sample which supports EXAFS, recent positron annihilation and these Mossbauer studies.

Determination of total lead in lipstick: development and validation of a microwave-assisted digestion, inductively coupled plasma-mass spectrometric method.

PubMed

Hepp, Nancy M; Mindak, William R; Cheng, John

2009-01-01

Recent reports describing the presence of lead (Pb) in lipsticks have suggested that, under ordinary use, the potential amount of Pb exposure is harmful. To permit independent assessment of the Pb contamination, a method for determining total Pb in lipstick using microwave-assisted digestion and analysis employing inductively coupled plasma-mass spectrometry (ICP-MS) was developed and validated. Since lipsticks may contain fats, oils, pigments, dyes, and minerals, several reference materials (RM) were analyzed, including coal, wear metals in oil, organic Pb in oil, milk powder, and estuarine sediment. With the exception of the RM with mineral content (estuarine sediment), complete recovery of Pb from the RMs was obtained by simple nitric acid (HNO(3)) digestion. Complete recovery of Pb from estuarine sediment was achieved only when hydrofluoric acid (HF) was added to the digestion mix, followed by treatment with excess boric acid (H(3)BO(3)) to neutralize the HF and to dissolve insoluble fluorides. Commercial lipsticks were tested for total Pb by the validated method. The detection limit was estimated to be 0.04 microg Pb/g. The average value obtained for the lipsticks was 1.07 microg/g. Undigested material was present in some lipstick digests when only HNO(3) was used, and generally lower Pb values were obtained. All of the Pb levels found by the U.S. Food and Drug Administration (FDA) were within the range the agency would expect to find in lipsticks formulated with permitted color additives and other ingredients prepared under good manufacturing practice (GMP) conditions. This method will be useful for the FDA and industry in helping to ensure the safety of cosmetic products.

REGENERATIVE MEDICINE AS APPLIED TO GENERAL SURGERY

PubMed Central

Orlando, Giuseppe; Wood, Kathryn J; De Coppi, Paolo; Baptista, Pedro M; Binder, Kyle W; Bitar, Khalil N; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H; Koch, Kenneth; Macchiarini, Paolo; Sani, Sayed-Hadi Mirmalek; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J; Soker, Shay

2012-01-01

The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues or organs in order to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate. PMID:22330032

Selection of Reliable Reference Genes for Gene Expression Studies on Rhododendron molle G. Don.

PubMed

Xiao, Zheng; Sun, Xiaobo; Liu, Xiaoqing; Li, Chang; He, Lisi; Chen, Shangping; Su, Jiale

2016-01-01

The quantitative real-time polymerase chain reaction (qRT-PCR) approach has become a widely used method to analyze expression patterns of target genes. The selection of an optimal reference gene is a prerequisite for the accurate normalization of gene expression in qRT-PCR. The present study constitutes the first systematic evaluation of potential reference genes in Rhododendron molle G. Don. Eleven candidate reference genes in different tissues and flowers at different developmental stages of R. molle were assessed using the following three software packages: GeNorm, NormFinder, and BestKeeper. The results showed that EF1- α (elongation factor 1-alpha), 18S (18s ribosomal RNA), and RPL3 (ribosomal protein L3) were the most stable reference genes in developing rhododendron flowers and, thus, in all of the tested samples, while tublin ( TUB ) was the least stable. ACT5 (actin), RPL3 , 18S , and EF1- α were found to be the top four choices for different tissues, whereas TUB was not found to favor qRT-PCR normalization in these tissues. Three stable reference genes are recommended for the normalization of qRT-PCR data in R. molle . Furthermore, the expression profiles of RmPSY (phytoene synthase) and RmPDS (phytoene dehydrogenase) were assessed using EF1- α, 18S , ACT5 , RPL3 , and their combination as internals. Similar trends were found, but these trends varied when the least stable reference gene TUB was used. The results further prove that it is necessary to validate the stability of reference genes prior to their use for normalization under different experimental conditions. This study provides useful information for reliable qRT-PCR data normalization in gene studies of R. molle .

Sulfate and sulfide sulfur isotopes (δ34S and δ33S) measured by solution and laser ablation MC-ICP-MS: An enhanced approach using external correction

USGS Publications Warehouse

Pribil, Michael; Ridley, William I.; Emsbo, Poul

2015-01-01

Isotope ratio measurements using a multi-collector inductively coupled plasma mass spectrometer (MC-ICP-MS) commonly use standard-sample bracketing with a single isotope standard for mass bias correction for elements with narrow-range isotope systems measured by MC-ICP-MS, e.g. Cu, Fe, Zn, and Hg. However, sulfur (S) isotopic composition (δ34S) in nature can range from at least − 40 to + 40‰, potentially exceeding the ability of standard-sample bracketing using a single sulfur isotope standard to accurately correct for mass bias. Isotopic fractionation via solution and laser ablation introduction was determined during sulfate sulfur (Ssulfate) isotope measurements. An external isotope calibration curve was constructed using in-house and National Institute of Standards and Technology (NIST) Ssulfate isotope reference materials (RM) in an attempt to correct for the difference. The ability of external isotope correction for Ssulfate isotope measurements was evaluated by analyzing NIST and United States Geological Survey (USGS) Ssulfate isotope reference materials as unknowns. Differences in δ34Ssulfate between standard-sample bracketing and standard-sample bracketing with external isotope correction for sulfate samples ranged from 0.72‰ to 2.35‰ over a δ34S range of 1.40‰ to 21.17‰. No isotopic differences were observed when analyzing Ssulfide reference materials over a δ34Ssulfide range of − 32.1‰ to 17.3‰ and a δ33S range of − 16.5‰ to 8.9‰ via laser ablation (LA)-MC-ICP-MS. Here, we identify a possible plasma induced fractionation for Ssulfate and describe a new method using external isotope calibration corrections using solution and LA-MC-ICP-MS.

ccML, a new mark-up language to improve ISO/EN 13606-based electronic health record extracts practical edition.

PubMed

Sánchez-de-Madariaga, Ricardo; Muñoz, Adolfo; Cáceres, Jesús; Somolinos, Roberto; Pascual, Mario; Martínez, Ignacio; Salvador, Carlos H; Monteagudo, José Luis

2013-01-01

The objective of this paper is to introduce a new language called ccML, designed to provide convenient pragmatic information to applications using the ISO/EN13606 reference model (RM), such as electronic health record (EHR) extracts editors. EHR extracts are presently built using the syntactic and semantic information provided in the RM and constrained by archetypes. The ccML extra information enables the automation of the medico-legal context information edition, which is over 70% of the total in an extract, without modifying the RM information. ccML is defined using a W3C XML schema file. Valid ccML files complement the RM with additional pragmatics information. The ccML language grammar is defined using formal language theory as a single-type tree grammar. The new language is tested using an EHR extracts editor application as proof-of-concept system. Seven ccML PVCodes (predefined value codes) are introduced in this grammar to cope with different realistic EHR edition situations. These seven PVCodes have different interpretation strategies, from direct look up in the ccML file itself, to more complex searches in archetypes or system precomputation. The possibility to declare generic types in ccML gives rise to ambiguity during interpretation. The criterion used to overcome ambiguity is that specificity should prevail over generality. The opposite would make the individual specific element declarations useless. A new mark-up language ccML is introduced that opens up the possibility of providing applications using the ISO/EN13606 RM with the necessary pragmatics information to be practical and realistic.

Ethanol postpolymerization treatment for improving the biocompatibility of acrylic reline resins.

PubMed

Neves, Cristina B; Lopes, Luís P; Ferrão, Helena F; Miranda, Joana P; Castro, Matilde F; Bettencourt, Ana F

2013-01-01

To evaluate the effect of postpolymerization treatment based on ethanol-aqueous solutions on the residual monomer (RM) content, flexural strength, microhardness, and cytotoxicity of hard chairside reline resins (Kooliner, Ufi Gel Hard). After polymerization, specimens were immersed in water, 20%, 50%, or 70% ethanol solutions at 23°C or 55°C for 10 minutes. Controls were left untreated. HPLC was used for the determination of RM content. Specimens were submitted to Vickers microhardness and 3-point loading flexural strength tests. Cytotoxicity of resin eluates was determined on human fibroblasts by assessing cellular mitochondrial function and lactate dehydrogenase release. Higher concentrations of ethanol promoted lower RM content at 55°C in both materials. The mechanical properties were maintained after 50% and 20% ethanol treatments in Kooliner and Ufi Gel Hard, respectively. Specimens submitted to those treatments showed significant reduction on cytotoxicity compared to immersion in hot water, the treatment of choice in the recent literature. Immersion of relined dentures in specific ethanol solutions at 55°C for 10 minutes can be considered an effective postpolymerization treatment contributing to increase materials biocompatibility. The proposed protocol is expeditious and easy to achieve with simple equipment in a dental office.

Kinect V2 Performance Assessment in Daily-Life Gestures: Cohort Study on Healthy Subjects for a Reference Database for Automated Instrumental Evaluations on Neurological Patients

PubMed Central

Malosio, Matteo; Molinari Tosatti, Lorenzo

2017-01-01

Background The increase of sanitary costs related to poststroke rehabilitation requires new sustainable and cost-effective strategies for promoting autonomous and dehospitalized motor training. In the Riprendo@Home and Future Home for Future Communities research projects, the promising approach of introducing low-cost technologies that promote home rehabilitation is exploited. In order to provide reliable evaluation of patients, a reference database of healthy people's performances is required and should consider variability related to healthy people performances. Methods 78 healthy subjects performed several repetitions of daily-life gestures, the reaching movement (RM) and hand-to-mouth (HtMM) movement with both the dominant and nondominant upper limbs. Movements were recorded with a Kinect V2. A synthetic biomechanical protocol based on kinematical, dynamical, and motor control parameters was used to assess motor performance of the healthy people. The investigation was conducted by clustering participants depending on their limb dominancy (right/left), gender (male/female), and age (young/middle/senior) as sources of variability. Results Results showed that limb dominancy has minor relevance in affecting RM and HtMM; gender has relevance in affecting the HtMM; age has major effect in affecting RM and HtMM. Conclusions An investigation of healthy subjects' upper limb performances during daily-life gestures was performed with the Kinect V2 sensor. Findings will be the basis for a database of normative data for neurological patients' motor evaluation. PMID:29358893

Intensities and spectral features of the {}^{4}{\\rm{I}}_{13/2}-{}^{4}{\\rm{I}}_{15/2} potential laser transition of Er3+ centers in CaF2-CeF3 disordered crystal

NASA Astrophysics Data System (ADS)

Wang, Qing-Guo; Su, Liangbi; Liu, Jun-Fang; Liu, Bin; Wu, Feng; Luo, Ping; Zhao, Heng-Yu; Shi, Jiao-Jiao; Xue, Yan-Yan; Xu, Xiao-Dong; Ryba-Romanowski, Witold; Solarz, Piotr; Lisiecki, Radoslaw; Wang, Zhan-Shan; Tang, Hui-Li; Xu, Jun

2017-10-01

Not Available Project supported by Shanghai Engineering Research Center for Sapphire Crystals, China (Grant No. 14DZ2252500), the Fund of Key Laboratory of Optoelectronic Materials Chemistry and Physics Chinese Academy of Sciences (Grant No. 2008DP17301), the Fundamental Research Funds for the Central Universities of China, the National Natural Science Foundation of China and China Academy of Engineering Physics Joint Fund (Grant No. U1530152), the National Natural Science Foundation of China (Grant Nos. 61475177 and 61621001), the Natural Science Foundation of Shanghai Municiple, China (Grant No. 13ZR1446100), and the MOE Key Laboratory of Advanced Micro-Structured Materials of China.

Undergraduate Seminars: The Poster Session Solution.

ERIC Educational Resources Information Center

Chute, Douglas L.; Bank, Barry

1983-01-01

A good alternative to the undergraduate psychology seminar is the poster session. During the course each student wrote a review paper. For use in his/her class presentation, the student provided the following information on poster paper: title, author, abstract, a few graphs or illustrations from the literature, conclusions, and references. (RM)

The color removal of dye wastewater by magnesium chloride/red mud (MRM) from aqueous solution.

PubMed

Wang, Qi; Luan, Zhaokun; Wei, Ning; Li, Jin; Liu, Chengxi

2009-10-30

In this study, the MgCl2/red mud system (MRM) was used to investigate the color removal efficiency of dye solutions. Parameters such as the effect of the dosage of red mud (RM) and MgCl2 have been studied. The effect of pH on the conversion rate of Mg2+ has also been studied. The color removal efficiency of MRM was compared with that of PAC/RM and PAC/NaOH. Meanwhile, the color removal efficiency of RM was compared with that of NaOH. The results show that the MRM system can remove more than 98% of the coloring material at a dosage of 25 g RM/L dye solution and a volume of 1.5 mL MgCl2/L dye solution in the decolorization process of reactive dye, acid dye and direct dye. The color removal efficiency was better than PAC/RM and PAC/NaOH system. The adsorption data have been analyzed using Langmuir and Freundlich isotherms. The results indicated that both models provide the best correlation of the experimental data. The decolorization mechanism of MRM was discussed, too. The MRM system was a viable alternative to some of the more conventional forms of chemical treatment of dye solutions and also provided another way to make use of industrial waste red mud.

Materials prediction via classification learning

DOE PAGES

Balachandran, Prasanna V.; Theiler, James; Rondinelli, James M.; ...

2015-08-25

In the paradigm of materials informatics for accelerated materials discovery, the choice of feature set (i.e. attributes that capture aspects of structure, chemistry and/or bonding) is critical. Ideally, the feature sets should provide a simple physical basis for extracting major structural and chemical trends and furthermore, enable rapid predictions of new material chemistries. Orbital radii calculated from model pseudopotential fits to spectroscopic data are potential candidates to satisfy these conditions. Although these radii (and their linear combinations) have been utilized in the past, their functional forms are largely justified with heuristic arguments. Here we show that machine learning methods naturallymore » uncover the functional forms that mimic most frequently used features in the literature, thereby providing a mathematical basis for feature set construction without a priori assumptions. We apply these principles to study two broad materials classes: (i) wide band gap AB compounds and (ii) rare earth-main group RM intermetallics. The AB compounds serve as a prototypical example to demonstrate our approach, whereas the RM intermetallics show how these concepts can be used to rapidly design new ductile materials. In conclusion, our predictive models indicate that ScCo, ScIr, and YCd should be ductile, whereas each was previously proposed to be brittle.« less

Materials Prediction via Classification Learning

PubMed Central

Balachandran, Prasanna V.; Theiler, James; Rondinelli, James M.; Lookman, Turab

2015-01-01

In the paradigm of materials informatics for accelerated materials discovery, the choice of feature set (i.e. attributes that capture aspects of structure, chemistry and/or bonding) is critical. Ideally, the feature sets should provide a simple physical basis for extracting major structural and chemical trends and furthermore, enable rapid predictions of new material chemistries. Orbital radii calculated from model pseudopotential fits to spectroscopic data are potential candidates to satisfy these conditions. Although these radii (and their linear combinations) have been utilized in the past, their functional forms are largely justified with heuristic arguments. Here we show that machine learning methods naturally uncover the functional forms that mimic most frequently used features in the literature, thereby providing a mathematical basis for feature set construction without a priori assumptions. We apply these principles to study two broad materials classes: (i) wide band gap AB compounds and (ii) rare earth-main group RM intermetallics. The AB compounds serve as a prototypical example to demonstrate our approach, whereas the RM intermetallics show how these concepts can be used to rapidly design new ductile materials. Our predictive models indicate that ScCo, ScIr, and YCd should be ductile, whereas each was previously proposed to be brittle. PMID:26304800

Masking of low-frequency signals by high-frequency, high-level narrow bands of noisea

PubMed Central

Patra, Harisadhan; Roup, Christina M.; Feth, Lawrence L.

2011-01-01

Low-frequency masking by intense high-frequency noise bands, referred to as remote masking (RM), was the first evidence to challenge energy-detection models of signal detection. Its underlying mechanisms remain unknown. RM was measured in five normal-hearing young-adults at 250, 350, 500, and 700 Hz using equal-power, spectrally matched random-phase noise (RPN) and low-noise noise (LNN) narrowband maskers. RM was also measured using equal-power, two-tone complex (TC2) and eight-tone complex (TC8). Maskers were centered at 3000 Hz with one or two equivalent rectangular bandwidths (ERBs). Masker levels varied from 80 to 95 dB sound pressure level in 5 dB steps. LNN produced negligible masking for all conditions. An increase in bandwidth in RPN yielded greater masking over a wider frequency region. Masking for TC2 was limited to 350 and 700 Hz for one ERB but shifted to only 700 Hz for two ERBs. A spread of masking to 500 and 700 Hz was observed for TC8 when the bandwidth was increased from one to two ERBs. Results suggest that high-frequency noise bands at high levels could generate significant low-frequency masking. It is possible that listeners experience significant RM due to the amplification of various competing noises that might have significant implications for speech perception in noise. PMID:21361445

Broadband Photometric Reverberation Mapping Analysis on SDSS-RM and Stripe 82 Quasars

NASA Astrophysics Data System (ADS)

Zhang, Haowen; Yang, Qian; Wu, Xue-Bing

2018-02-01

We modified the broadband photometric reverberation mapping (PRM) code, JAVELIN, and tested the availability to get broad-line region time delays that are consistent with the spectroscopic reverberation mapping (SRM) project SDSS-RM. The broadband light curves of SDSS-RM quasars produced by convolution with the system transmission curves were used in the test. We found that under similar sampling conditions (evenly and frequently sampled), the key factor determining whether the broadband PRM code can yield lags consistent with the SRM project is the flux ratio of the broad emission line to the reference continuum, which is in line with the previous findings. We further found a critical line-to-continuum flux ratio, about 6%, above which the mean of the ratios between the lags from PRM and SRM becomes closer to unity, and the scatter is pronouncedly reduced. We also tested our code on a subset of SDSS Stripe 82 quasars, and found that our program tends to give biased lag estimations due to the observation gaps when the R-L relation prior in Markov Chain Monte Carlo is discarded. The performance of the damped random walk (DRW) model and the power-law (PL) structure function model on broadband PRM were compared. We found that given both SDSS-RM-like or Stripe 82-like light curves, the DRW model performs better in carrying out broadband PRM than the PL model.

Value of automatic patient motion detection and correction in myocardial perfusion imaging using a CZT-based SPECT camera.

PubMed

van Dijk, Joris D; van Dalen, Jorn A; Mouden, Mohamed; Ottervanger, Jan Paul; Knollema, Siert; Slump, Cornelis H; Jager, Pieter L

2018-04-01

Correction of motion has become feasible on cadmium-zinc-telluride (CZT)-based SPECT cameras during myocardial perfusion imaging (MPI). Our aim was to quantify the motion and to determine the value of automatic correction using commercially available software. We retrospectively included 83 consecutive patients who underwent stress-rest MPI CZT-SPECT and invasive fractional flow reserve (FFR) measurement. Eight-minute stress acquisitions were reformatted into 1.0- and 20-second bins to detect respiratory motion (RM) and patient motion (PM), respectively. RM and PM were quantified and scans were automatically corrected. Total perfusion deficit (TPD) and SPECT interpretation-normal, equivocal, or abnormal-were compared between the noncorrected and corrected scans. Scans with a changed SPECT interpretation were compared with FFR, the reference standard. Average RM was 2.5 ± 0.4 mm and maximal PM was 4.5 ± 1.3 mm. RM correction influenced the diagnostic outcomes in two patients based on TPD changes ≥7% and in nine patients based on changed visual interpretation. In only four of these patients, the changed SPECT interpretation corresponded with FFR measurements. Correction for PM did not influence the diagnostic outcomes. Respiratory motion and patient motion were small. Motion correction did not appear to improve the diagnostic outcome and, hence, the added value seems limited in MPI using CZT-based SPECT cameras.

Effect of a self-adhesive coating on the load-bearing capacity of tooth-coloured restorative materials.

PubMed

Bagheri, R; Palamara, Jea; Mese, A; Manton, D J

2017-03-01

The aim of this study was to compare the flexural strength and Vickers hardness of tooth-coloured restorative materials with and without applying a self-adhesive coating for up to 6 months. Specimens were prepared from three resin composites (RC), two resin-modified glass-ionomer cements (RM-GIC) and two conventional glass-ionomer cements (CGIC). All materials were tested both with and without applying G-Coat Plus (GCP). Specimens were conditioned in 37 °C distilled deionized water for 24 h, and 1, 3 and 6 months. The specimens were strength tested using a four-point bend test jig in a universal testing machine. The broken specimen's halves were used for Vickers hardness testing. Representative specimens were examined under an environmental scanning electron microscope. Data analysis showed that regardless of time and materials, generally the surface coating was associated with a significant increase in the flexural strength of the materials. Applying the GCP decreased the hardness of almost all materials significantly (P < 0.05) and effect of time intervals on hardness was material dependent. The load-bearing capacity of the restorative materials was affected by applying self-adhesive coating and ageing. The CGIC had significantly higher hardness but lower flexural strength than the RM-GIC and RC. © 2016 Australian Dental Association.

Bioleaching of rare earth and radioactive elements from red mud using Penicillium tricolor RM-10.

PubMed

Qu, Yang; Lian, Bin

2013-05-01

The aim of this work is to investigate biological leaching of rare earth elements (REEs) and radioactive elements from red mud, and to evaluate the radioactivity of the bioleached red mud used for construction materials. A filamentous, acid-producing fungi named RM-10, identified as Penicillium tricolor, is isolated from red mud. In our bioleaching experiments by using RM-10, a total concentration of 2% (w/v) red mud under one-step bioleaching process was generally found to give the maximum leaching ratios of the REEs and radioactive elements. However, the highest extraction yields are achieved under two-step bioleaching process at 10% (w/v) pulp density. At pulp densities of 2% and 5% (w/v), red mud processed under both one- and two-step bioleaching can meet the radioactivity regulations in China. Copyright © 2013 Elsevier Ltd. All rights reserved.

Crystal Growth and Scintillation Properties of $${\\rm Cs}_{2}{\\rm NaGdBr}_{6}{:}{\\rm Ce}^{3+}$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Pin; Zhou, Xiaowang; Deng, Haoran

2013-04-02

Single crystals of Cs 2NaGdBr 6 with different Ce +3 activator concentrations were grown by a two-zone Bridgman method. This new compound belongs to a large elpasolite halide (A 2BLnX 6) family. Many of these elpasolite compounds have shown high luminosity, good energy resolution and excellent proportionality in comparison to traditional scintillators such as CsI and NaI; therefore, they are particularly attractive for gamma-ray spectroscopy applications. This study investigated the scintillator properties of Cs 2NaGdBr 6:Ce +3 crystals as a new material for radiation detection. Special focus has been placed on the effects of activator concentration (0 to 50 mol.%)more » on the photoluminescence responses. Results of structural refinement, photoluminescence, radioluminescence, lifetime and proportionality measurements for this new compound are reported.« less

Evaluation of Functional Marrow Irradiation Based on Skeletal Marrow Composition Obtained Using Dual-Energy Computed Tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Magome, Taiki; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Radiology, The University of Tokyo Hospital, Tokyo

Purpose: To develop an imaging method to characterize and map marrow composition in the entire skeletal system, and to simulate differential targeted marrow irradiation based on marrow composition. Methods and Materials: Whole-body dual energy computed tomography (DECT) images of cadavers and leukemia patients were acquired, segmented to separate bone marrow components, namely, bone, red marrow (RM), and yellow marrow (YM). DECT-derived marrow fat fraction was validated using histology of lumbar vertebrae obtained from cadavers. The fractions of RM (RMF = RM/total marrow) and YMF were calculated in each skeletal region to assess the correlation of marrow composition with sites and ages. Treatmentmore » planning was simulated to target irradiation differentially at a higher dose (18 Gy) to either RM or YM and a lower dose (12 Gy) to the rest of the skeleton. Results: A significant correlation between fat fractions obtained from DECT and cadaver histology samples was observed (r=0.861, P<.0001, Pearson). The RMF decreased in the head, neck, and chest was significantly inversely correlated with age but did not show any significant age-related changes in the abdomen and pelvis regions. Conformity of radiation to targets (RM, YM) was significantly dependent on skeletal sites. The radiation exposure was significantly reduced (P<.05, t test) to organs at risk (OARs) in RM and YM irradiation compared with standard total marrow irradiation (TMI). Conclusions: Whole-body DECT offers a new imaging technique to visualize and measure skeletal-wide marrow composition. The DECT-based treatment planning offers volumetric and site-specific precise radiation dosimetry of RM and YM, which varies with aging. Our proposed method could be used as a functional compartment of TMI for further targeted radiation to specific bone marrow environment, dose escalation, reduction of doses to OARs, or a combination of these factors.« less

Prevalence and correlates of willingness to participate in a rectal microbicide trial among men who have sex with men in Bangkok.

PubMed

Thienkrua, Warunee; Todd, Catherine S; Chaikummao, Supaporn; Sukwicha, Wichuda; Yafant, Somsak; Tippanont, Narongritt; Varangrat, Anchalee; Khlaimanee, Pechpailin; Holtz, Timothy H

2014-01-01

Rectal microbicides (RMs) hold promise as a HIV prevention method to reduce transmission among men who have sex with men (MSM). To assess RM trial feasibility in Bangkok, we measured prevalence and correlates of willingness to participate among Thai MSM observational cohort participants. Between April 2006 and December 2010, 1744 MSM enrolled in the Bangkok MSM Cohort Study; at 12 months, RM trial participation willingness was measured. We evaluated correlates of RM trial participation willingness using logistic regression analysis. Participants completing the 12-month visit (81.4%, n = 1419) had a mean age of 27.3 years (SD = 6.1), and 65.5% and 86.1% reported having a steady partner or anal intercourse (AI) in the past four months, respectively. Most (79.1%, n = 1123) participants reported willingness to participate in an RM trial, which, in multivariable analysis, was independently associated with insertive only (adjusted odds ratio [AOR] = 3.25, 95% CI: 1.82-5.81) or receptive/versatile role AI (AOR = 3.07, 95% CI: 1.88-5.01), and being paid for sex (AOR = 12.15, 95% CI: 1.67-88.21) in the past four months, and believing that people with AIDS look sick (AOR = 1.92, 95% CI: 1.23-2.98). Of hypothetical RM trial features to increase enrollment likelihood, the most (91.1%) compelling was that the study be approved by the Thai ethics committee, followed by the study site offering evening hours (88.9%). Reasons not to participate were not wanting a rectal examination (29.5%) or fluid collected from the penis or anus (24.6%) and not wanting the placebo (23.0%). RM trial participation willingness was high, particularly for those with greater HIV acquisition risk, within this Thai MSM cohort, suggesting feasibility of an RM trial. Addressing potential barriers to trial entry may be useful in educational materials to optimize recruitment.

RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring

PubMed Central

Huang, Haiyu; Zhao, Peisen; Chen, Pai-Yen; Ren, Yong; Liu, Xuewu; Ferrari, Mauro; Hu, Ye; Akinwande, Deji

2014-01-01

Miniaturized helix antennas are integrated with drug reservoirs to function as RFID wireless tag sensors for real-time drug dosage monitoring. The general design procedure of this type of biomedical antenna sensors is proposed based on electromagnetic theory and finite element simulation. A cost effective fabrication process is utilized to encapsulate the antenna sensor within a biocompatible package layer using PDMS material, and at the same time form a drug storage or drug delivery unit inside the sensor. The in vitro experiment on two prototypes of antenna sensor-drug reservoir assembly have shown the ability to monitor the drug dosage by tracking antenna resonant frequency shift from 2.4–2.5-GHz ISM band with realized sensitivity of 1.27 \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$\\mu~{\\rm l}/{\\rm MHz}$\\end{document} for transdermal drug delivery monitoring and 2.76-\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$\\mu~{\\rm l}/{\\rm MHz}$\\end{document} sensitivity for implanted drug delivery monitoring. PMID:27170865

76 FR 80838 - Filing of Privileged Materials and Answers to Motions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... extension of time or a shortened time period for action, then answers to the motion to extend or shorten the..., 375, 380, 385 and 388 [Docket No. RM12-2-000] Filing of Privileged Materials and Answers to Motions AGENCY: Federal Energy Regulatory Commission, Energy. ACTION: Notice of Proposed Rulemaking. SUMMARY: The...

In search of late time evolution self-similar scaling laws of Rayleigh-Taylor and Richtmyer-Meshkov hydrodynamic instabilities - recent theorical advance and NIF Discovery-Science experiments

NASA Astrophysics Data System (ADS)

Shvarts, Dov

2017-10-01

Hydrodynamic instabilities, and the mixing that they cause, are of crucial importance in describing many phenomena, from very large scales such as stellar explosions (supernovae) to very small scales, such as inertial confinement fusion (ICF) implosions. Such mixing causes the ejection of stellar core material in supernovae, and impedes attempts at ICF ignition. The Rayleigh-Taylor instability (RTI) occurs at an accelerated interface between two fluids with the lower density accelerating the higher density fluid. The Richtmyer-Meshkov (RM) instability occurs when a shock wave passes an interface between the two fluids of different density. In the RTI, buoyancy causes ``bubbles'' of the light fluid to rise through (penetrate) the denser fluid, while ``spikes'' of the heavy fluid sink through (penetrate) the lighter fluid. With realistic multi-mode initial conditions, in the deep nonlinear regime, the mixing zone width, H, and its internal structure, progress through an inverse cascade of spatial scales, reaching an asymptotic self-similar evolution: hRT =αRT Agt2 for RT and hRM =αRM tθ for RM. While this characteristic behavior has been known for years, the self-similar parameters αRT and θRM and their dependence on dimensionality and density ratio have continued to be intensively studied and a relatively wide distribution of those values have emerged. This talk will describe recent theoretical advances in the description of this turbulent mixing evolution that sheds light on the spread in αRT and θRM. Results of new and specially designed experiments, done by scientists from several laboratories, were performed recently using NIF, the only facility that is powerful enough to reach the self-similar regime, for quantitative testing of this theoretical advance, will be presented.

The Pedagogy of Fear and Guilt: How Textbooks Treat the World Economy.

ERIC Educational Resources Information Center

Newitt, Jane

1984-01-01

The central finding of a review of 63 high school history, geography, civics, and economics textbooks is that the textbooks are not accurately describing the world economy. For example, few of the texts refer to economic gains being made by many countries or mention the existence of middle income countries. (RM)

Slaying the Food Monster: Help for Bulimics.

ERIC Educational Resources Information Center

Snyder, Francine; Levy, Karen Gorbitz

1984-01-01

Bulimia is an eating disorder often referred to as the binge-purge syndrome. The bulimic usually functions well at work and often holds a top-level position. Reasons for bulimia include feelings of inadequacy, societal pressures to be thin, and high parental expectations. Low self-esteem is a common characteristic of the bulimic. (RM)

Genetics Home Reference: Langerhans cell histiocytosis

MedlinePlus

... Oct;29(5):853-73. doi: 10.1016/j.hoc.2015.06.005. Epub 2015 Aug 18. Review. Citation on PubMed Nelson DS, van Halteren A, Quispel WT, van den Bos C, Bovée JV, Patel B, Badalian-Very G, van Hummelen P, Ducar M, Lin L, MacConaill LE, Egeler RM, ...

The study of high-speed surface dynamics using a pulsed proton beam

NASA Astrophysics Data System (ADS)

Buttler, William T.; Oro, David M.; Preston, Dean; Mikaelian, Karnig O.; Cherne, Frank J.; Hixson, Robert S.; Mariam, Fesseha G.; Morris, Christopher L.; Stone, Joseph B.; Terrones, Guillermo; Tupa, Dale

2012-03-01

We present experimental results supporting physics based ejecta model development, where we assume ejecta form as a special limiting case of a Richtmyer-Meshkov (RM) instability with Atwood number A = -1. We present and use data to test established RM spike and bubble growth rate theory through application of modern laser Doppler velocimetry techniques applied in a novel manner to coincidentally measure bubble and spike velocities from shocked metals. We also explore the link of ejecta formation from a solid material to its plastic flow stress at high-strain rates (107/s) and high strains (700%).

Rare earth element and rare metal inventory of central Asia

USGS Publications Warehouse

Mihalasky, Mark J.; Tucker, Robert D.; Renaud, Karine; Verstraeten, Ingrid M.

2018-03-06

Rare earth elements (REE), with their unique physical and chemical properties, are an essential part of modern living. REE have enabled development and manufacture of high-performance materials, processes, and electronic technologies commonly used today in computing and communications, clean energy and transportation, medical treatment and health care, glass and ceramics, aerospace and defense, and metallurgy and chemical refining. Central Asia is an emerging REE and rare metals (RM) producing region. A newly compiled inventory of REE-RM-bearing mineral occurrences and delineation of areas-of-interest indicate this region may have considerable undiscovered resources.

Annotated Bibliography on Apartheid.

ERIC Educational Resources Information Center

Totten, Sam, ed.

1985-01-01

This annotated listing on apartheid in South Africa cites general resources, classroom materials, fiction, poetry, audio visuals, and organizations and associations. Also included are a glossary and a brief chronology of South Africa's apartheid system. (RM)

Reference Model 6 (RM6): Oscillating Wave Energy Converter.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bull, Diana L; Smith, Chris; Jenne, Dale Scott

This report is an addendum to SAND2013-9040: Methodology for Design and Economic Analysis of Marine Energy Conversion (MEC) Technologies. This report describes an Oscillating Water Column Wave Energy Converter reference model design in a complementary manner to Reference Models 1-4 contained in the above report. In this report, a conceptual design for an Oscillating Water Column Wave Energy Converter (WEC) device appropriate for the modeled reference resource site was identified, and a detailed backward bent duct buoy (BBDB) device design was developed using a combination of numerical modeling tools and scaled physical models. Our team used the methodology in SAND2013-9040more » for the economic analysis that included costs for designing, manufacturing, deploying, and operating commercial-scale MEC arrays, up to 100 devices. The methodology was applied to identify key cost drivers and to estimate levelized cost of energy (LCOE) for this RM6 Oscillating Water Column device in dollars per kilowatt-hour ($/kWh). Although many costs were difficult to estimate at this time due to the lack of operational experience, the main contribution of this work was to disseminate a detailed set of methodologies and models that allow for an initial cost analysis of this emerging technology. This project is sponsored by the U.S. Department of Energy's (DOE) Wind and Water Power Technologies Program Office (WWPTO), within the Office of Energy Efficiency & Renewable Energy (EERE). Sandia National Laboratories, the lead in this effort, collaborated with partners from National Laboratories, industry, and universities to design and test this reference model.« less

Impact of 10-Minute Interval Roller Massage on Performance and Active Range of Motion.

PubMed

Hodgson, D D; Quigley, P J; Whitten, J H D; Reid, J C; Behm, David G

2017-11-16

Hodgson, DD, Quigley, PJ, Whitten, JHD, Reid, JC, and Behm, DG. Impact of 10-minute interval roller massage on performance and active range of motion. J Strength Cond Res XX(X): 000-000, 2017-Roller massage (RM) has been shown to increase range of motion (ROM) without subsequent performance deficits. However, prolonged static stretching (SS) can induce performance impairments. The objective of this study was to examine the effects of combining SS and RM with and without subsequent RM on ROM and neuromuscular performance. Subjects (n = 12) participated in 5 sessions: (a) SS only (SS_rest), (b) SS + RM (SS + RM_rest), (c) SS with RM at 10 and 20 minutes after stretch (SS_RM), (d) SS + RM with RM at 10 and 20 minutes after stretch (SS + RM_RM), and (e) control. For the SS conditions, the quadriceps and hamstrings received passive SS for 2 × 30 seconds each. For the SS + RM conditions, SS was applied to the quadriceps and hamstrings for 30 seconds each, and RM was performed for 30 seconds per muscle. SS_RM and SS + RM_RM conditions received an additional 30-second RM at 10 and 20 minutes after warm-up, whereas sessions without additional RM rested for the same duration. Testing measures included hip flexion (HF) and knee flexion (KF) active and passive ROM, hurdle jump height and contact time, countermovement jump height, and maximal voluntary isometric contraction force. Initial KF and HF ROM improvements provided by SS_RM and SS + RM_RM were sustained up to 30 minutes after intervention. Furthermore, SS_RM exhibited greater ROM compared with sessions lacking additional RM in active and passive HF as well as active and passive KF. Similarly, SS + RM_RM elicited greater KF and HF ROM improvements than SS_rest. In conclusion, active KF and HF ROM improvements were prolonged by additional RM, whereas neuromuscular performance remained relatively unaffected.

Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task.

PubMed

MacQueen, David A; Dalrymple, Savannah R; Drobes, David J; Diamond, David M

2016-06-01

Developed as a tool to assess working memory capacity in rodents, the odor span task (OST) has significant potential to advance drug discovery in animal models of psychiatric disorders. Prior investigations indicate OST performance is impaired by systemic administration of N-methyl-d-aspartate receptor (NMDA-r) antagonists and is sensitive to cholinergic manipulations. The present study sought to determine whether an impairment in OST performance can be produced by systemic administration of the competitive NMDA-r antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP; 3, 10, 17 mg/kg i.p.) in a unique dual-component variant of the OST, and whether this impairment is ameliorated by nicotine (0.75 mg/kg i.p.). Male Sprague-Dawley rats were trained to asymptotic level of performance on a 24-trial two-comparison incrementing nonmatching to sample OST. In addition, rats were administered a two-comparison olfactory reference memory (RM) task, which was integrated into the OST. The RM task provided an assessment of the effects of drug administration on global behavioral measures, long-term memory and motivation. Several measures of working memory (span, longest run, and accuracy) were dose dependently impaired by CPP without adversely affecting RM. Analysis of drug effects across trial blocks demonstrated a significant impairment of performance even at low memory loads, suggesting a CPP-induced deficit of olfactory short-term memory that is not load-dependent. Although nicotine did not ameliorate CPP-induced impairments in span or accuracy, it did block the impairment in longest run produced by the 10 mg/kg dose of CPP. Overall, our results indicate that performance in our 24 odor two-comparison OST is capacity dependent and that CPP impaired OST working, but not reference, memory. © 2016 MacQueen et al.; Published by Cold Spring Harbor Laboratory Press.

SU-E-T-195: Gantry Angle Dependency of MLC Leaf Position Error

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ju, S; Hong, C; Kim, M

Purpose: The aim of this study was to investigate the gantry angle dependency of the multileaf collimator (MLC) leaf position error. Methods: An automatic MLC quality assurance system (AutoMLCQA) was developed to evaluate the gantry angle dependency of the MLC leaf position error using an electronic portal imaging device (EPID). To eliminate the EPID position error due to gantry rotation, we designed a reference maker (RM) that could be inserted into the wedge mount. After setting up the EPID, a reference image was taken of the RM using an open field. Next, an EPID-based picket-fence test (PFT) was performed withoutmore » the RM. These procedures were repeated at every 45° intervals of the gantry angle. A total of eight reference images and PFT image sets were analyzed using in-house software. The average MLC leaf position error was calculated at five pickets (-10, -5, 0, 5, and 10 cm) in accordance with general PFT guidelines using in-house software. This test was carried out for four linear accelerators. Results: The average MLC leaf position errors were within the set criterion of <1 mm (actual errors ranged from -0.7 to 0.8 mm) for all gantry angles, but significant gantry angle dependency was observed in all machines. The error was smaller at a gantry angle of 0° but increased toward the positive direction with gantry angle increments in the clockwise direction. The error reached a maximum value at a gantry angle of 90° and then gradually decreased until 180°. In the counter-clockwise rotation of the gantry, the same pattern of error was observed but the error increased in the negative direction. Conclusion: The AutoMLCQA system was useful to evaluate the MLC leaf position error for various gantry angles without the EPID position error. The Gantry angle dependency should be considered during MLC leaf position error analysis.« less

Ethanol Postpolymerization Treatment for Improving the Biocompatibility of Acrylic Reline Resins

PubMed Central

Neves, Cristina B.; Lopes, Luís P.; Ferrão, Helena F.; Miranda, Joana P.; Castro, Matilde F.; Bettencourt, Ana F.

2013-01-01

Objective. To evaluate the effect of postpolymerization treatment based on ethanol-aqueous solutions on the residual monomer (RM) content, flexural strength, microhardness, and cytotoxicity of hard chairside reline resins (Kooliner, Ufi Gel Hard). Methods. After polymerization, specimens were immersed in water, 20%, 50%, or 70% ethanol solutions at 23°C or 55°C for 10 minutes. Controls were left untreated. HPLC was used for the determination of RM content. Specimens were submitted to Vickers microhardness and 3-point loading flexural strength tests. Cytotoxicity of resin eluates was determined on human fibroblasts by assessing cellular mitochondrial function and lactate dehydrogenase release. Results. Higher concentrations of ethanol promoted lower RM content at 55°C in both materials. The mechanical properties were maintained after 50% and 20% ethanol treatments in Kooliner and Ufi Gel Hard, respectively. Specimens submitted to those treatments showed significant reduction on cytotoxicity compared to immersion in hot water, the treatment of choice in the recent literature. Significance. Immersion of relined dentures in specific ethanol solutions at 55°C for 10 minutes can be considered an effective postpolymerization treatment contributing to increase materials biocompatibility. The proposed protocol is expeditious and easy to achieve with simple equipment in a dental office. PMID:23971038

Stretching Screens and Imaginations.

ERIC Educational Resources Information Center

Douthwaite, Shelaugh

1983-01-01

Secondary students utilize a simplified technique to make silk screen prints, which can be printed onto T-shirts. The only materials needed from art suppliers are a few squeegees and a few yards of polyester screen mesh. (RM)

State-to-state dynamics of {\\rm{F}}({}^{2}{\\rm{P}})+{\\rm{HO}}({}^{2}{\\rm{\\Pi }})\\to {\\rm{O}}({}^{3}{\\rm{P}})+{\\rm{HF}}({}^{1}{\\rm{\\Sigma }}^{+}) reaction on {1}^{3}{{\\rm{A}}}^{\\prime\\prime} potential energy surface

NASA Astrophysics Data System (ADS)

Zhao, Juan; Wu, Hui; Sun, Hai-Bo; Wang, Li-Fei

2018-02-01

Not Available Project supported by the National Natural Science Foundation of China (Grant Nos. 11504206 and 11404049), the China Postdoctoral Science Foundation (CPSF) (Grant No. 2014M561259), and the Ph. D. Research Start-up Fund of Shandong Jiaotong University.

Reservoir Maintenance and Development Task Report for the DOE Geothermal Technologies Office GeoVision Study.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowry, Thomas Stephen; Finger, John T.; Carrigan, Charles R.

This report documents the key findings from the Reservoir Maintenance and Development (RM&D) Task of the U.S. Department of Energy's (DOE), Geothermal Technologies Office (GTO) Geothermal Vision Study (GeoVision Study). The GeoVision Study had the objective of conducting analyses of future geothermal growth based on sets of current and future geothermal technology developments. The RM&D Task is one of seven tasks within the GeoVision Study with the others being, Exploration and Confirmation, Potential to Penetration, Institutional Market Barriers, Environmental and Social Impacts, Thermal Applications, and Hybrid Systems. The full set of findings and the details of the GeoVision Study canmore » be found in the final GeoVision Study report on the DOE-GTO website. As applied here, RM&D refers to the activities associated with developing, exploiting, and maintaining a known geothermal resource. It assumes that the site has already been vetted and that the resource has been evaluated to be of sufficient quality to move towards full-scale development. It also assumes that the resource is to be developed for power generation, as opposed to low-temperature or direct use applications. This document presents the key factors influencing RM&D from both a technological and operational standpoint and provides a baseline of its current state. It also looks forward to describe areas of research and development that must be pursued if the development geothermal energy is to reach its full potential.« less

Observations by Juno's Radiation Monitoring Investigation During the First Year at Jupiter

NASA Astrophysics Data System (ADS)

Becker, H. N.; Adumitroaie, V.; Alexander, J. W.; Daubar, I.; Joergensen, J. L.; Denver, T.; Benn, M.; Adriani, A.; Mura, A.; Cicchetti, A.; Noschese, R.; Connerney, J. E. P.; Gladstone, R.; Hue, V.; Versteeg, M.; Santos-Costa, D.; Bolton, S. J.; Levin, S.; Thorne, R. M.

2017-12-01

Juno's Radiation Monitoring (RM) Investigation measures MeV electron fluxes at Jupiter by utilizing the noise signatures of penetrating high-energy particles which are visible in images collected by Juno's heavily shielded star cameras and science instruments. Image processing is used to identify and extract the characteristic signatures of penetrating high-energy electrons and ions and derive count rates which are used to infer external integral electron flux levels [Becker, H.N., et al. (2017), Space Sci Rev, doi: 10.1007/s11214-017-0345-9; Becker H.N. et al. (2017), Geophys. Res. Lett., 44, doi:10.1002/2017GL073091]. The count rate data from each RM instrument represents detection of electrons from within a broad energy channel (e.g. > 5 MeV or > 10 MeV electron sensitivity, determined using Geant4 shielding analysis). Simultaneous observations by the instruments therefore allow study of the external spectra where coordinated measurements are achieved. The spacecraft Stellar Reference Unit (SRU), the Magnetic Field Investigation's Advanced Stellar Compass (ASC) camera head D, and the Jovian Infrared Auroral Mapper (JIRAM) infrared imager are the primary instruments used in RM's collaborative observation campaigns. Penetrating particle signatures and trends across a broader range of Juno instruments and spacecraft housekeeping data also contribute to the analysis. This paper presents an overview of RM measurements of the Jovian high energy particle environment observed during the first eight science orbits of Juno's prime mission.

Down-Looking Interferometer Study II, Volume I,

DTIC Science & Technology

1980-03-01

g(standard deviation of AN )(standard deviation of(3) where T’rm is the "reference spectrum", an estimate of the actual spectrum v gv T ’V Cgv . If jpj...spectrum T V . cgv . According to Eq. (2), Z is the standard deviation of the observed contrast spectral radiance AN divided by the effective rms system

78 FR 16876 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

....'' For problems with ADAMS, please contact the NRC's Public Document Room (PDR) reference staff at 1-800...://www.nrc.gov/reading-rm/adams.html . Persons who do not have access to ADAMS or who encounter problems... basis perspective they do affect the probability that missiles generated by the winds of the tornado...

40 CFR 63.1349 - Performance testing requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) THC emissions test. (i) If you are subject to limitations on THC emissions, you must operate a CEMS in... assurance evaluations for CEMS, the THC span value (as propane) is 50 ppmvd and the reference method (RM) is Method 25A of appendix A to part 60 of this chapter. (ii) Use the THC CEMS to conduct the initial...

Music of Other Cultures in the Classroom.

ERIC Educational Resources Information Center

Miller, Samuel D.; Brand, Manny

1983-01-01

Studying ethnic music promotes a deeper understanding and acceptance of other peoples and provides an opportunity to study musical concepts. How to choose music materials to enhance social studies is discussed. A brief annotated bibliography is included. (RM)

Role of soft-iron impellers on the mode selection in the von kármán-sodium dynamo experiment.

PubMed

Giesecke, André; Stefani, Frank; Gerbeth, Gunter

2010-01-29

A crucial point for the understanding of the von Kármán-sodium (VKS) dynamo experiment is the influence of soft-iron impellers. We present numerical simulations of a VKS-like dynamo with a localized permeability distribution that resembles the shape of the flow driving impellers. It is shown that the presence of soft-iron material essentially determines the dynamo process in the VKS experiment. An axisymmetric magnetic field mode can be explained by the combined action of the soft-iron disk and a rather small alpha effect parametrizing the induction effects of unresolved small scale flow fluctuations.

Bathymetric and underwater video survey of Lower Granite Reservoir and vicinity, Washington and Idaho, 2009-10

USGS Publications Warehouse

Williams, Marshall L.; Fosness, Ryan L.; Weakland, Rhonda J.

2012-01-01

The U.S. Geological Survey conducted a bathymetric survey of the Lower Granite Reservoir, Washington, using a multibeam echosounder, and an underwater video mapping survey during autumn 2009 and winter 2010. The surveys were conducted as part of the U.S. Army Corps of Engineer's study on sediment deposition and control in the reservoir. The multibeam echosounder survey was performed in 1-mile increments between river mile (RM) 130 and 142 on the Snake River, and between RM 0 and 2 on the Clearwater River. The result of the survey is a digital elevation dataset in ASCII coordinate positioning data (easting, northing, and elevation) useful in rendering a 3×3-foot point grid showing bed elevation and reservoir geomorphology. The underwater video mapping survey was conducted from RM 107.73 to 141.78 on the Snake River and RM 0 to 1.66 on the Clearwater River, along 61 U.S. Army Corps of Engineers established cross sections, and dredge material deposit transects. More than 900 videos and 90 bank photographs were used to characterize the sediment facies and ground-truth the multibeam echosounder data. Combined, the surveys were used to create a surficial sediment facies map that displays type of substrate, level of embeddedness, and presence of silt.

O Some Theoretical Studies and Applications of Light Scattering by Small Particles

NASA Astrophysics Data System (ADS)

Zhan, Jiyu

1992-01-01

A theoretical study of the interference structure of the Mie extinction cross section Q_{ rm ext} is presented. For real refractive indices m < 2.5 the dominant term of Q _{rm ext} has an x dependence of the form sin^2 ((m - 1)x), leading to the periodicity of Deltax = pi/(m - 1). At m > 2.5 the Q _{rm ext} curve does not have a simple periodic structure. Analytical expression for absorption and scattering coefficients of polydispersion of hexagonal plates, that are used to model fluffy snow flakes, are derived by the anomalous diffraction approximation (ADA). The results are within 12% accuracy when compared to the calculations of the superposition of dipoles method. A method for measuring the real part of the refractive indices of phytoplankton, bacteria or other particulate material suspended in seawater is developed based on the ADA. The accuracy in determining the real part of the refractive index is around 0.005.

Transmission electron microscopy study of microstructural properties and dislocation characterization in the GaN film grown on the cone-shaped patterned Al2O3 substrate.

PubMed

Park, Jung Sik; Yang, Jun-Mo; Park, Kyung Jin; Park, Yun Chang; Yoo, Jung Ho; Jeong, Chil Seong; Park, Jucheol; He, Yinsheng; Shin, Keesam

2014-02-01

Growing a GaN film on a patterned Al2O3 substrate is one of the methods of reducing threading dislocations (TDs), which can significantly deteriorate the performance of GaN-based LEDs. In this study, the microstructural details of the GaN film grown on a cone-shaped patterned Al2O3 substrate were investigated using high-resolution transmission electron microscopy and weak-beam dark-field techniques. Various defects such as misfit dislocations (MDs), recrystallized GaN (R-GaN) islands and nano-voids were observed on the patterned Al2O3 surfaces, i.e. the flat surface (FS), the inclined surface (IS) and the top surface (TS), respectively. Especially, the crystallographic orientation of R-GaN between the GaN film and the inclined Al2O3 substrate was identified as $[\\overline 1 2\\overline 1 0]_{{\\rm GaN}} \\hbox{//}[\\overline 1 101]_{{\\rm R - GaN} \\,{\\rm on}\\,{\\rm IS}} \\hbox{//}[\\overline 1 100]_{ {{\\rm Al}} _{\\rm 2} {\\rm O}_{\\rm 3}} $, $(\\overline 1 012)_{{\\rm GaN}} \\hbox{//}(1\\overline 1 02)_{{\\rm R - Ga}\\,{\\rm Non}\\,{\\rm IS}} \\hbox{//}(\\overline {11} 26)_{ {{\\rm Al}} _{\\rm 2} {\\rm O}_{\\rm 3}} $. In addition, a rotation by 9° between $(10\\overline 1 1)_{{\\rm R - GaN}} $ and $(0002)_{{\\rm GaN}} $ and between $(10\\overline 1 1)_{{\\rm R - GaN}} $ and $(0006)_{ {{\\rm Al}} _{\\rm 2} {\\rm O}_{\\rm 3}} $ was found to reduce the lattice mismatch between the GaN film and the Al2O3 substrate. Many TDs in the GaN film were observed on the FS and TS of Al2O3. However, few TDs were observed on the IS. Most of the TDs generated from the FS of Al2O3 were bent to the inclined facet rather than propagating to the GaN surface, resulting in a reduction in the dislocation density. Most of the TDs generated from the TS of Al2O3 were characterized as edge dislocations.

Memory complaints in amnestic Mild Cognitive Impairment: More prospective or retrospective?

PubMed

de Mendonça, Alexandre; Felgueiras, Helena; Verdelho, Ana; Câmara, Sara; Grilo, Cláudia; Maroco, João; Pereira, Antonina; Guerreiro, Manuela

2018-05-15

Patients with amnestic Mild Cognitive Impairment (aMCI), usually considered an early stage of Alzheimer's disease, have deficits not only in retrospective memory (RM), that is, recalling of past events, words or people, but also on prospective memory (PM), the cognitive ability of remembering to execute delayed intentions in the future. This study investigated whether patients with aMCI refer more PM complaints as compared with RM complaints, and whether this might depend upon short-term vs long-term items or time-based vs event-based tasks. Patients with aMCI (n = 178) and healthy controls (n = 160) underwent the Prospective and Retrospective Memory Questionnaire (PRMQ), a 16-item instrument to appraise differences between PM and RM complaints, as well as a general mental state examination, a subjective memory complaints questionnaire, objective memory tests, and assessment of depressive symptoms and activities of daily living. Patients with aMCI reported more memory complaints evaluated with the PRMQ (total score = 44.3 ± 10.8) as compared with controls (36.7 ± 9.8, P < 0.001). Using a mixed effect repeated-measures analysis of covariance (ANCOVA) showed that participants generally referred more retrospective than prospective memory complaints. Patients with aMCI had significantly more complaints on short-term memory as compared with long-term memory, and more complaints in time-based (auto-initiated) as compared with event-based tasks, than healthy controls. Patients with aMCI reported significantly more difficulties on short-term memory, presumably reflecting internal temporal lobe pathology typical of Alzheimer's disease, and more complaints on time-based tasks, which are cognitively very demanding, but did not seem particularly troubled regarding prospective memory. Copyright © 2018 John Wiley & Sons, Ltd.

Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.

PubMed

Pratt, Victoria M; Everts, Robin E; Aggarwal, Praful; Beyer, Brittany N; Broeckel, Ulrich; Epstein-Baak, Ruth; Hujsak, Paul; Kornreich, Ruth; Liao, Jun; Lorier, Rachel; Scott, Stuart A; Smith, Chingying Huang; Toji, Lorraine H; Turner, Amy; Kalman, Lisa V

2016-01-01

Pharmacogenetic testing is increasingly available from clinical laboratories. However, only a limited number of quality control and other reference materials are currently available to support clinical testing. To address this need, the Centers for Disease Control and Prevention-based Genetic Testing Reference Material Coordination Program, in collaboration with members of the pharmacogenetic testing community and the Coriell Cell Repositories, has characterized 137 genomic DNA samples for 28 genes commonly genotyped by pharmacogenetic testing assays (CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP4F2, DPYD, GSTM1, GSTP1, GSTT1, NAT1, NAT2, SLC15A2, SLC22A2, SLCO1B1, SLCO2B1, TPMT, UGT1A1, UGT2B7, UGT2B15, UGT2B17, and VKORC1). One hundred thirty-seven Coriell cell lines were selected based on ethnic diversity and partial genotype characterization from earlier testing. DNA samples were coded and distributed to volunteer testing laboratories for targeted genotyping using a number of commercially available and laboratory developed tests. Through consensus verification, we confirmed the presence of at least 108 variant pharmacogenetic alleles. These samples are also being characterized by other pharmacogenetic assays, including next-generation sequencing, which will be reported separately. Genotyping results were consistent among laboratories, with most differences in allele assignments attributed to assay design and variability in reported allele nomenclature, particularly for CYP2D6, UGT1A1, and VKORC1. These publicly available samples will help ensure the accuracy of pharmacogenetic testing. Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

Brillouin Scattering from Opaque Semiconducting Alloys and Thin Films.

NASA Astrophysics Data System (ADS)

Krabach, Timothy Norbert

Brillouin scattering spectra were measured in MBE grown single crystal films of Al_{ rm x}Ga_{rm 1 - x}As alloys and Al_{ rm x}Ga_{rm 1 - x}As-GaAs superlattices on GaAs substrates, and GaAs films grown on miscut Si substrates. To detect the Brillouin shifted light against the strong elastic background present in opaque materials, a tandem multipass Fabry-Perot system was designed and constructed, providing high resolution and contrast. Scattering from both surface and bulk acoustic waves were used to derive information on the elastic and dielectric constants of Al_{rm x}Ga_{rm 1 - x} As alloys. The surface acoustic wave velocities along the (100) and (110) axes were measured for a number of aluminum concentrations. In samples that were transparent to the exciting laser frequency, a leaky surface longitudinal wave was also observed. By fitting to this data, the elastic constants as a function of alloy concentration were found to be c_{11} = 11.88 + 0.05x, c_{12} = 5.38 + 1.6x, and c_{44} = 5.95 - .8x (times 10^{10} dyn/cm ^2). Scattering from bulk acoustic waves was used to measure the complex index of refraction. The results agree very closely with previous ellipsometric data. Spectra were taken on two superlattices and compared to an alloy of the same average aluminum concentration. No differences were seen in the acoustic velocities or the index of refraction. Brillouin spectra taken of GaAs films on Si exhibited peaks due to acoustic waves trapped in the film. The dispersion curves of these modes as a function of wavevector were fitted by using the bulk elastic constants of GaAs and Si. The good fit obtained, and the narrowness of the peaks, are corroborating evidence of the high crystalline quality of these films.

Lung recruitment maneuver effects on respiratory mechanics and extravascular lung water index in patients with acute respiratory distress syndrome.

PubMed

Zhang, Jian-Guo; Chen, Xiao-Juan; Liu, Fen; Zeng, Zhen-Guo; Qian, Ke-Jian

2011-01-01

Animal experiments showed that recruitment maneuver (RM) and protective ventilation strategy of the lung could improve oxygenation and reduce extravascular lung water. This study was to investigate the effects of RM on respiratory mechanics and extravascular lung water index (EVLWI) in patients with acute respiratory distress syndrome (ARDS). Thirty patients with ARDS were randomized into a RM group and a non-RM group. In the RM group, after basic mechanical ventilation stabilized for 30 minutes, RM was performed and repeated once every 12 hours for 3 days. In the non-RM group, lung protective strategy was conducted without RM. Oxygenation index (PaO2/FiO2), peak inspiratory pressure (PIP), Plateau pressure (Pplat), static pulmonary compliance (Cst) and EVLWI of patients before treatment and at 12, 24, 48, 72 hours after the treatment were measured and compared between the groups. Hemodynamic changes were observed before and after RM. One-way ANOVA, Student's t test and Fisher's exact test were used to process the data. The levels of PaO2/FiO2 and Cst increased after treatment in the two groups, but they were higher in the RM group than in the non-RM group (P<0.05). The PIP and Pplat decreased after treatment in the two groups, but they were lower in the RM group than in the non-RM group (P<0.05). The EVLWI in the two groups showed downward trend after treatment (P<0.05), and the differences were signifcant at all time points (P<0.01); the EVLWI in the RM group was lower than that in the non-RM group at 12, 24, 48 and 72 hours (P<0.05 or P<0.01). Compared with pre-RM, hemodynamics changes during RM were significantly different (P<0.01); compared with pre-RM, the changes were not significantly different at 120 seconds after the end of RM (P>0.05). RM could reduce EVLWI, increase oxygenation and lung compliance. The effect of RM on hemodynamics was transient.

Meeting the Expectations of the Social Studies Teacher at a Teacher Center.

ERIC Educational Resources Information Center

Schober, Helen

1984-01-01

Teacher centers respond to a teacher's own defined needs by offering assistance, instruction, and materials to help enrich classroom learning experiences. Services provided social studies educators by the Teacher Center in Humboldt County, California, are described. (RM)

Assessment of environmental risk for red mud storage facility in China: a case study in Shandong Province.

PubMed

Wen, Zhi-Chao; Ma, Shu-Hua; Zheng, Shi-Li; Zhang, Yi; Liang, Yan

2016-06-01

Red mud storage facility (RM-SF) pollution remains a serious problem in China mainly due to the RM's huge quantity, little recyclability, and high alkalinity. And, there is also a risk of dam failure because almost all RM-SFs are processed by damming. In order to address this challenge and improve the level of risk management, it is necessary to evaluate the environmental risk of RM-SFs systematically. So, this paper firstly designs a comprehensive evaluation index system with a three-level evaluation index in the terms of RM characteristics, RM-SF characteristics, ambient environment of RM-SF, the management of RM-SF, and the application aspect of RM by the analytic hierarchy process (AHP) method. Then, a case of RM-SF from a typical alumina production enterprise is studied according to this system, as is assisted by several experts from different fields when determining the weights of all indicators. The results show that the risk of selected RM-SF primarily depends on the former factors, that is, RM and RM-SF characteristics, while the contributions of the other factors are quite smaller.

Electro-mechanical vibration analysis of functionally graded piezoelectric porous plates in the translation state

NASA Astrophysics Data System (ADS)

Wang, Yan Qing

2018-02-01

To provide reference for aerospace structural design, electro-mechanical vibrations of functionally graded piezoelectric material (FGPM) plates carrying porosities in the translation state are investigated. A modified power law formulation is employed to depict the material properties of the plates in the thickness direction. Three terms of inertial forces are taken into account due to the translation of plates. The geometrical nonlinearity is considered by adopting the von Kármán non-linear relations. Using the d'Alembert's principle, the nonlinear governing equation of the out-of-plane motion of the plates is derived. The equation is further discretized to a system of ordinary differential equations using the Galerkin method, which are subsequently solved via the harmonic balance method. Then, the approximate analytical results are validated by utilizing the adaptive step-size fourth-order Runge-Kutta technique. Additionally, the stability of the steady state responses is examined by means of the perturbation technique. Linear and nonlinear vibration analyses are both carried out and results display some interesting dynamic phenomenon for translational porous FGPM plates. Parametric study shows that the vibration characteristics of the present inhomogeneous structure depend on several key physical parameters.

A compiled catalog of rotation measures of radio point sources

NASA Astrophysics Data System (ADS)

Xu, Jun; Han, Jin-Lin

2014-08-01

We compiled a catalog of Faraday rotation measures (RMs) for 4553 extragalactic radio point sources published in literature. These RMs were derived from multi-frequency polarization observations. The RM data are compared to those in the NRAO VLA Sky Survey (NVSS) RM catalog. We reveal a systematic uncertainty of about 10.0 ± 1.5 rad m-2 in the NVSS RM catalog. The Galactic foreground RM is calculated through a weighted averaging method by using the compiled RM catalog together with the NVSS RM catalog, with careful consideration of uncertainties in the RM data. The data from the catalog and the interface for the Galactic foreground RM calculations are publicly available on the webpage: http://zmtt.bao.ac.cn/RM/.

Faraday rotation at low frequencies: magnetoionic material of the large FRII radio galaxy PKS J0636-2036

NASA Astrophysics Data System (ADS)

O'Sullivan, S. P.; Lenc, E.; Anderson, C. S.; Gaensler, B. M.; Murphy, T.

2018-04-01

We present a low-frequency, broad-band polarization study of the FRII radio galaxy PKS J0636-2036 (z = 0.0551), using the Murchison Widefield Array (MWA) from 70 to 230 MHz. The northern and southern hotspots (separated by ˜14.5 arcmin on the sky) are resolved by the MWA (3.3 arcmin resolution) and both are detected in linear polarization across the full frequency range. A combination of Faraday rotation measure (RM) synthesis and broad-band polarization model fitting is used to constrain the Faraday depolarization properties of the source. For the integrated southern hotspot emission, two-RM-component models are strongly favoured over a single RM component, and the best-fitting model requires Faraday dispersions of approximately 0.7 and 1.2 rad m-2 (with a mean RM of ˜50 rad m-2). High-resolution imaging at 5 arcsec with the Australia Telescope Compact Array shows significant sub-structure in the southern hotspot and highlights some of the limitations in the polarization modelling of the MWA data. Based on the observed depolarization, combined with extrapolations of gas density scaling relations for group environments, we estimate magnetic field strengths in the intergalactic medium between ˜0.04 and 0.5 μG. We also comment on future prospects of detecting more polarized sources at low frequencies.

MAGNETOROTATIONAL TURBULENCE TRANSPORTS ANGULAR MOMENTUM IN STRATIFIED DISKS WITH LOW MAGNETIC PRANDTL NUMBER BUT MAGNETIC REYNOLDS NUMBER ABOVE A CRITICAL VALUE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oishi, Jeffrey S.; Mac Low, Mordecai-Mark, E-mail: jsoishi@stanford.edu, E-mail: mordecai@amnh.org

2011-10-10

The magnetorotational instability (MRI) may dominate outward transport of angular momentum in accretion disks, allowing material to fall onto the central object. Previous work has established that the MRI can drive a mean-field dynamo, possibly leading to a self-sustaining accretion system. Recently, however, simulations of the scaling of the angular momentum transport parameter {alpha}{sub SS} with the magnetic Prandtl number Pm have cast doubt on the ability of the MRI to transport astrophysically relevant amounts of angular momentum in real disk systems. Here, we use simulations including explicit physical viscosity and resistivity to show that when vertical stratification is included,more » mean-field dynamo action operates, driving the system to a configuration in which the magnetic field is not fully helical. This relaxes the constraints on the generated field provided by magnetic helicity conservation, allowing the generation of a mean field on timescales independent of the resistivity. Our models demonstrate the existence of a critical magnetic Reynolds number Rm{sub crit}, below which transport becomes strongly Pm-dependent and chaotic, but above which the transport is steady and Pm-independent. Prior simulations showing Pm dependence had Rm < Rm{sub crit}. We conjecture that this steady regime is possible because the mean-field dynamo is not helicity-limited and thus does not depend on the details of the helicity ejection process. Scaling to realistic astrophysical parameters suggests that disks around both protostars and stellar mass black holes have Rm >> Rm{sub crit}. Thus, we suggest that the strong Pm dependence seen in recent simulations does not occur in real systems.« less

Magnetorotational Turbulence Transports Angular Momentum in Stratified Disks with Low Magnetic Prandtl Number but Magnetic Reynolds Number above a Critical Value

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oishi, Jeffrey S.; /KIPAC, Menlo Park; Low, Mordecai-Mark Mac

2012-02-14

The magnetorotational instability (MRI) may dominate outward transport of angular momentum in accretion disks, allowing material to fall onto the central object. Previous work has established that the MRI can drive a mean-field dynamo, possibly leading to a self-sustaining accretion system. Recently, however, simulations of the scaling of the angular momentum transport parameter {alpha}{sub SS} with the magnetic Prandtl number Pm have cast doubt on the ability of the MRI to transport astrophysically relevant amounts of angular momentum in real disk systems. Here, we use simulations including explicit physical viscosity and resistivity to show that when vertical stratification is included,more » mean field dynamo action operates, driving the system to a configuration in which the magnetic field is not fully helical. This relaxes the constraints on the generated field provided by magnetic helicity conservation, allowing the generation of a mean field on timescales independent of the resistivity. Our models demonstrate the existence of a critical magnetic Reynolds number Rm{sub crit}, below which transport becomes strongly Pm-dependent and chaotic, but above which the transport is steady and Pm-independent. Prior simulations showing Pm-dependence had Rm < Rm{sub crit}. We conjecture that this steady regime is possible because the mean field dynamo is not helicity-limited and thus does not depend on the details of the helicity ejection process. Scaling to realistic astrophysical parameters suggests that disks around both protostars and stellar mass black holes have Rm >> Rm{sub crit}. Thus, we suggest that the strong Pm dependence seen in recent simulations does not occur in real systems.« less

An investigation of the feasibility of applying Raman microscopy for exploring stained glass

NASA Astrophysics Data System (ADS)

Bouchard, Michel; Smith, David C.; Carabatos-Nédelec, Constantin

2007-12-01

Raman microscopy (RM) is widely used in archaeometrical studies of pigments, geomaterials and biomaterials in the Cultural Heritage, but one domain has received relatively less attention: the colouring of stained glass. This feasibility study investigates the advantages and disadvantages of employing RM alone in this field by means of a study of modern commercial glasses, modern commercial pigments, and a few archaeological stained glasses, but especially by an experimental project whereby the authors created stained glass. The different kinds of possible unreacted or reacted material are rigorously established. The distinction between Na, K, Ca glasses was explored, as well as the red colouring of an industrial glass which was proved to be due to the presence of (Zn, Cd)S xSe 1- x. Yellow, green, blue and maroon pigments were studied before and after an initial firing and then after heating on glass. The quality of the Raman spectra varied enormously and was sometimes disappointing. Nevertheless RM successfully identified various coloured products such as bindheimite, crocoite, cobalt aluminate, haematite; relict reactants such as corundum, eskolaite and oxides of Co or Pb; and provided indications of other phases such as maghemite or Co-olivine. One conclusion is that the amount of chemical reaction between the pigments and the glass is small compared to the amount in between the pigments. Comments are made on the potential for dating archaeological glass from the known age of synthesis of the pigments, and of the dangers of this approach. Overall it has been shown that RM can be useful for studying stained glass, especially for remote in situ analytical operations with mobile RM, but one must expect some problems either with fluorescence or weak spectra.

Phosphate removal from aqueous solutions using raw and activated red mud and fly ash.

PubMed

Li, Yanzhong; Liu, Changjun; Luan, Zhaokun; Peng, Xianjia; Zhu, Chunlei; Chen, Zhaoyang; Zhang, Zhongguo; Fan, Jinghua; Jia, Zhiping

2006-09-01

The effect of acidification and heat treatment of raw red mud (RM) and fly ash (FA) on the sorption of phosphate was studied in parallel experiments. The result shows that a higher efficiency of phosphate removal was acquired by the activated samples than by the raw ones. The sample prepared by using the RM stirred with 0.25 M HCl for 2h (RM0.25), as well as another sample prepared by heating the RM at 700 degrees C for 2h (RM700), registered the maximum removal of phosphate (99% removal of phosphate). This occurred when they were used in the phosphate sorption studies conducted at pH 7.0 and 25 degrees C with the initial PO(4)(3-) concentration of 155 mg P/l. The FA samples treated in the same way described above can achieve 7.0 and 8.2 mg P/l phosphate removal for FA0.25 and FA700 respectively, corresponding to 45.2% and 52.9% removal. The activated materials performed higher phosphate removal over broader pH range compared with the raw ones. The influences of various factors, such as initial pH and initial phosphate concentration on the sorption capacity were also studied in batch equilibration technique. Solution pH significantly influenced the sorption. Each sample achieved the maximal removal of phosphate at pH 7.0. The amount of phosphate removal increased with the solute concentration. The Freundlich and Langmuir models were used to simulate the sorption equilibrium. The results indicate that the Langmuir model has a better correlation with the experimental data than the Freundlich model.

Development Feasibility of Missile Datcom

DTIC Science & Technology

1981-10-01

performed through analysis of the world’s missile systems. Their characteristics were extracted from "Jane’s Weapon Systems" (reference 2), and the...A^ "" Ba(l * V) * «• B»(l - v) »gA «VfB2»2 - 1) 372 (i **> --1 sh^T -(1 - **> --1 knSS| Van VB2 *2 rM.* (^«2*^); (^P)>U«I00 2

Particle size distributions by transmission electron microscopy: an interlaboratory comparison case study

PubMed Central

Rice, Stephen B; Chan, Christopher; Brown, Scott C; Eschbach, Peter; Han, Li; Ensor, David S; Stefaniak, Aleksandr B; Bonevich, John; Vladár, András E; Hight Walker, Angela R; Zheng, Jiwen; Starnes, Catherine; Stromberg, Arnold; Ye, Jia; Grulke, Eric A

2015-01-01

This paper reports an interlaboratory comparison that evaluated a protocol for measuring and analysing the particle size distribution of discrete, metallic, spheroidal nanoparticles using transmission electron microscopy (TEM). The study was focused on automated image capture and automated particle analysis. NIST RM8012 gold nanoparticles (30 nm nominal diameter) were measured for area-equivalent diameter distributions by eight laboratories. Statistical analysis was used to (1) assess the data quality without using size distribution reference models, (2) determine reference model parameters for different size distribution reference models and non-linear regression fitting methods and (3) assess the measurement uncertainty of a size distribution parameter by using its coefficient of variation. The interlaboratory area-equivalent diameter mean, 27.6 nm ± 2.4 nm (computed based on a normal distribution), was quite similar to the area-equivalent diameter, 27.6 nm, assigned to NIST RM8012. The lognormal reference model was the preferred choice for these particle size distributions as, for all laboratories, its parameters had lower relative standard errors (RSEs) than the other size distribution reference models tested (normal, Weibull and Rosin–Rammler–Bennett). The RSEs for the fitted standard deviations were two orders of magnitude higher than those for the fitted means, suggesting that most of the parameter estimate errors were associated with estimating the breadth of the distributions. The coefficients of variation for the interlaboratory statistics also confirmed the lognormal reference model as the preferred choice. From quasi-linear plots, the typical range for good fits between the model and cumulative number-based distributions was 1.9 fitted standard deviations less than the mean to 2.3 fitted standard deviations above the mean. Automated image capture, automated particle analysis and statistical evaluation of the data and fitting coefficients provide a framework for assessing nanoparticle size distributions using TEM for image acquisition. PMID:26361398

Whistler turbulence heating of electrons and ions: Three-dimensional particle-in-cell simuations

DOE PAGES

Gary, S. Peter; Hughes, R. Scott; Wang, Joseph

2016-01-14

In this study, the decay of whistler turbulence in a collisionless, homogeneous, magnetized plasma is studied using three-dimensional particle-in-cell simulations. The simulations are initialized with a narrowband, relatively isotropic distribution of long wavelength whistler modes. A first ensemble of simulations at electron betamore » $${\\beta }_{{\\rm{e}}}$$ = 0.25 and ion-to-electron mass ratio $${m}_{{\\rm{i}}}$$/$${m}_{{\\rm{e}}}$$ = 400 is carried out on a domain cube of dimension $$L{\\omega }_{\\mathrm{pi}}$$/c = 5.12 where $${\\omega }_{\\mathrm{pi}}$$ is the ion plasma frequency. The simulations begin with a range of dimensionless fluctuating field energy densities, $${\\epsilon }_{{\\rm{o}}}$$, and follow the fluctuations as they cascade to broadband, anisotropic turbulence which dissipates at shorter wavelengths, heating both electrons and ions. The electron heating is stronger and preferentially parallel/antiparallel to the background magnetic field $${{\\boldsymbol{B}}}_{{\\rm{o}}};$$ the ion energy gain is weaker and is preferentially in directions perpendicular to $${{\\boldsymbol{B}}}_{{\\rm{o}}}$$. The important new results here are that, over 0.01 < $${\\epsilon }_{{\\rm{o}}}$$ < 0.25, the maximum rate of electron heating scales approximately as $${\\epsilon }_{{\\rm{o}}}$$, and the maximum rate of ion heating scales approximately as $${\\epsilon }_{{\\rm{o}}}^{1.5}$$. A second ensemble of simulations at $${\\epsilon }_{{\\rm{o}}}$$ = 0.10 and $${\\beta }_{{\\rm{e}}}$$ = 0.25 shows that, over 25 < $${m}_{{\\rm{i}}}$$/$${m}_{{\\rm{e}}}\\;$$< 1836, the ratio of the maximum ion heating rate to the maximum electron heating rate scales approximately as $${m}_{{\\rm{e}}}$$/$${m}_{{\\rm{i}}}$$.« less

Reliability and Validity of the Load-Velocity Relationship to Predict the 1RM Back Squat.

PubMed

Banyard, Harry G; Nosaka, Kazunori; Haff, G Gregory

2017-07-01

Banyard, HG, Nosaka, K, and Haff, GG. Reliability and validity of the load-velocity relationship to predict the 1RM back squat. J Strength Cond Res 31(7): 1897-1904, 2017-This study investigated the reliability and validity of the load-velocity relationship to predict the free-weight back squat one repetition maximum (1RM). Seventeen strength-trained males performed three 1RM assessments on 3 separate days. All repetitions were performed to full depth with maximal concentric effort. Predicted 1RMs were calculated by entering the mean concentric velocity of the 1RM (V1RM) into an individualized linear regression equation, which was derived from the load-velocity relationship of 3 (20, 40, 60% of 1RM), 4 (20, 40, 60, 80% of 1RM), or 5 (20, 40, 60, 80, 90% of 1RM) incremental warm-up sets. The actual 1RM (140.3 ± 27.2 kg) was very stable between 3 trials (ICC = 0.99; SEM = 2.9 kg; CV = 2.1%; ES = 0.11). Predicted 1RM from 5 warm-up sets up to and including 90% of 1RM was the most reliable (ICC = 0.92; SEM = 8.6 kg; CV = 5.7%; ES = -0.02) and valid (r = 0.93; SEE = 10.6 kg; CV = 7.4%; ES = 0.71) of the predicted 1RM methods. However, all predicted 1RMs were significantly different (p ≤ 0.05; ES = 0.71-1.04) from the actual 1RM. Individual variation for the actual 1RM was small between trials ranging from -5.6 to 4.8% compared with the most accurate predictive method up to 90% of 1RM, which was more variable (-5.5 to 27.8%). Importantly, the V1RM (0.24 ± 0.06 m·s) was unreliable between trials (ICC = 0.42; SEM = 0.05 m·s; CV = 22.5%; ES = 0.14). The load-velocity relationship for the full depth free-weight back squat showed moderate reliability and validity but could not accurately predict 1RM, which was stable between trials. Thus, the load-velocity relationship 1RM prediction method used in this study cannot accurately modify sessional training loads because of large V1RM variability.

The Generation and Detection of Rydberg Wavepackets

NASA Astrophysics Data System (ADS)

Meyler, P. E.

Available from UMI in association with The British Library. Requires signed TDF. A Rydberg wavepacket is a coherent superposition of several electronic energy eigenstates corresponding to the high lying energy levels of an atom. In this thesis, an experiment is described in which a radially localized Rydberg wavepacket is excited in atomic rubidium by a picosecond optical pump pulse. The wavepacket has a mean effective principal quantum number v_0 = 62, which corresponds to a classical orbit period T _{rm cl} = 37 ps. The subsequent evolution of the wavepacket is probed by a delayed, picosecond optical pulse. The resulting photoionization signal is measured as a function of pump-probe delay, and initially displays peaks separated by T_{rm cl}. This classical oscillation then collapses, after which a fractional revival of period T_ {rm cl}/2 is observed, followed finally by a full revival of the wavepacket. These results constitute the first experimental observation of a fractional revival in any system, and are shown to be in good agreement with theoretical predictions. The results of the experiment are discussed with reference to the correspondence principle and it is concluded that even in the limit of large quantum numbers, the evolution of a given system can be dominated by quantum mechanical effects.

Cell-derived microparticles and vascular pregnancy complications: a systematic and comprehensive review.

PubMed

Alijotas-Reig, Jaume; Palacio-Garcia, Carles; Llurba, Elisa; Vilardell-Tarres, Miquel

2013-02-01

To assess current studies on the relationship between cell-derived microparticles (cMP) and recurrent miscarriages (RM) and pre-eclampsia (PE), and review the relationships between cMP and inflammatory and clot pathways, antiphospholipid antibodies (aPL), cytokines, and pregnancy complications. Systematic and comprehensive review of the literature from January 2000 to January 2012. Vall d'Hebron University Hospital. Women with recurrent miscarriages or PE, healthy nonpregnant women, and healthy pregnant women. None. Comparison of cMP numbers and types among groups. Platelet and endothelial cMP are increased in women with normal pregnancies compared with nonpregnant healthy women. Only five case-control studies regarding cMP and RM and 16 on cMP and PE were found to match our objective. Three of five articles referring to RM showed differences in cMP numbering, and 13 of 16 on cMP and PE showed differences in some type of cMP compared with controls. Cell-derived microparticles were raised in normal pregnancy. Recurrent miscarriage seems to be related to endothelial and platelet cell activation and/or consumption. An increase in almost all cMP types was observed in PE. A relationship between cMP and endothelial activation and proinflammatory status seems to exist. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

VizieR Online Data Catalog: Rotation measures of radio point sources (Xu+, 2014)

NASA Astrophysics Data System (ADS)

Xu, J.; Han, J.-L.

2015-04-01

We compiled a catalog of Faraday rotation measures (RMs) for 4553 extragalactic radio point sources published in literature. These RMs were derived from multi-frequency polarization observations. The RM data are compared to those in the NRAO VLA Sky Survey (NVSS) RM catalog. We reveal a systematic uncertainty of about 10.0+/-1.5rad/m2 in the NVSS RM catalog. The Galactic foreground RM is calculated through a weighted averaging method by using the compiled RM catalog together with the NVSS RM catalog, with careful consideration of uncertainties in the RM data. The data from the catalog and the interface for the Galactic foreground RM calculations are publicly available on the webpage: http://zmtt.bao.ac.cn/RM/ . (2 data files).

Turmoil: A Simulation Game Dealing With International Oil Trade

ERIC Educational Resources Information Center

Kelly, Robert

1976-01-01

This simulation game is intended to help secondary students understand the complexities of the international oil trade. Students represent nations involved in trading oil and other commodities. The game takes about five classroom periods to teach. The article includes all essential materials. (Author/RM)

Genotoxic and cytotoxic effects of different types of dental cement on normal cultured human lymphocytes.

PubMed

Bakopoulou, A; Mourelatos, D; Tsiftsoglou, A S; Giassin, N P; Mioglou, E; Garefis, P

2009-01-31

In this study we have investigated the genotoxic and cytotoxic effects of eluates derived from different types of commercially available dental cements, including glass ionomer cements (GICs) (Ketac Cem/3M ESPE and GC Fuji I/GC Corp), resin-modified glass ionomer cements (RM-GICs) (RelyX Luting/3M ESPE and Vitrebond/3M ESPE) and dual-cure resin cements (RCs) (Variolink II/ Ivoclar-Vivadent and Panavia F 2.0/Kuraray) on normal cultured human lymphocytes. Lymphocyte primary cultures obtained from blood samples of three healthy donors were exposed to serial dilutions of eluates derived from specimens of each material tested. Metaphases were induced with phytohaemagglutinin, collected after 72h treatment by use of colchicine and stained according to the fluorescence plus giemsa (FPG) procedure. Preparations were scored for sister chromatid exchange (SCE) and chromosomal aberrations (CAs), while the proliferation rate index (PRI) was also calculated. Our results show that eluates derived from the RM-GICs and RCs caused severe genotoxic effects by significantly increasing the frequencies of SCEs and CAs in cultures of peripheral blood lymphocytes and by decreasing the relevant PRI values in a dose-dependent manner, whereas the two GICs caused only minor cytogenetic effects. Eluates of the two RM-GICs (Vitrebond and RelyX) were also very cytotoxic, as the first serial dilutions of both materials caused a complete mitotic arrest in lymphocyte cultures. Overall, the degree of genotoxicity and cytotoxicity caused by dental cements decreased as follows: Viterbond>Rely X>Panavia F 2.0>Variolink II>Ketac Cem=GC Fuji I. These results indicate that different types of dental cement differ extensively in their genotoxic and cytotoxic potential and their ability to affect chromosomal integrity, cell-cycle progression, DNA replication and repair. Although these results cannot be directly extrapolated to the clinical situation, the potential occurrence of adverse effects caused by the RM-GICs and RCs tested in this study should be considered when making a clinical decision about dental cements.

Stable azodye photo-alignment layer for liquid crystal devices achieved by "turning off" dye photosensitivity

NASA Astrophysics Data System (ADS)

McGinty, C.; Finnemeyer, V.; Reich, R.; Clark, H.; Berry, S.; Bos, P.

2017-11-01

We have previously proposed a low cost, versatile process for stabilizing azodye photo-alignment layers for liquid crystal devices by utilizing a surface localized reactive mesogen (RM) layer. The RM is applied by dissolving the monomer in a liquid crystal material prior to filling the cell. In this paper, we show the significant effect of azodye layer thickness on the long term stability of these alignment layers when exposed to polarized light. We demonstrate, surprisingly, that thin azodye layers (˜3 nm) provide improved stability over thicker (˜40 nm) layers. Using this process, we show cells which have been stable to exposure with polarized light through one month. Additionally, we demonstrate the use of a photo-alignment layer to align the liquid crystals that afterwards can be rendered insensitive to polarized light. This was accomplished by using the process described above with the additional step of eliminating the photosensitivity of the azodye layer through photo-bleaching; the result is an RM alignment layer that will be stable when exposed to polarized light in the dye absorption band.

Anomalous scaling of Δ C versus T c in the Fe-based superconductors: the $${S}_{\\pm }$$-wave pairing state model

DOE PAGES

Bang, Yunkyu; Stewart, G. R.

2016-02-01

The strong power law behavior of the specific heat jumpmore » $${\\rm{\\Delta }}C\\;$$ versus T c $$({\\rm{\\Delta }}C/{T}_{{\\rm{c}}}\\sim {T}_{{\\rm{c}}}^{\\alpha },\\alpha \\approx 2)$$, first observed by Bud'ko et al (2009 Phys. Rev. B 79 220516), has been confirmed with several families of the Fe-based superconducting compounds with various dopings. We tested a minimal two band BCS model to understand this anomalous behavior and showed that this non-BCS relation between $${\\rm{\\Delta }}C\\;$$ versus T c is a generic property of the multiband superconducting state paired by a dominant interband interaction ($${V}_{\\mathrm{inter}}\\gt {V}_{\\mathrm{intra}}$$) reflecting the relation $$\\frac{{{\\rm{\\Delta }}}_{{\\rm{h}}}}{{{\\rm{\\Delta }}}_{{\\rm{e}}}}\\sim \\sqrt{\\frac{{N}_{{\\rm{e}}}}{{N}_{{\\rm{h}}}}}$$ near T c, as in the $${S}_{\\pm }$$-wave pairing state. We also found that this $${\\rm{\\Delta }}C\\;$$ versus T c power law can continuously change from the ideal BNC scaling to a considerable deviation by a moderate variation of the impurity scattering rate $${{\\rm{\\Gamma }}}_{0}$$ (non-pair-breaking). Finally, as a result, our model provides a consistent explanation why the electron-doped Fe-based superconductors follow the ideal BNC scaling very well while the hole-doped systems often show varying degree of deviations.« less

Treatment of intrabony defects with resorbable materials, non-resorbable materials and flap debridement.

PubMed

Zybutz, M D; Laurell, L; Rapoport, D A; Persson, G R

2000-03-01

Different types of barriers are used in guided tissue regenerative procedures. This prospective study compared resorbable citric acid ester softened polylactic acid membranes (RM) and non-resorbable expanded polytetrafluoroethylene (ePTFE) barriers (NRM) in GTR treatment of intrabony defects. 29 subjects were randomly assigned to the RM group or NRM group. Each patient received one GTR procedure. An open flap debridement (FD) was performed at another site 2 weeks later to evaluate healing potential. Clinical treatment outcomes were finally evaluated 12 months after surgery for changes of pocket depth PD, probing attachment level PAL, and probing bone level PBL, and radiographically for bone change using standardised radiographs. No differences in healing patters after surgery were found between patients in the 2 study groups as evaluated from the FD surgical procedures. NRM treated sites showed less signs of post-surgical inflammation during the 1st 4 weeks of healing than did RM treated sites (p<0.05). GTR-treated defects in the RM group, initially 7.0+/-2.2 mm deep, showed PD reduction of 3.3+/-2.2 mm, PAL gain of 2.4+/-1.8 mm, PBL gain of 2.4+/-3.7 mm (28%) and a radiographic bone fill of 2.3+/-2.4 mm. Defects treated with the NRM exhibited PD reduction of 3.1+/-2.1 mm, PAL gain of 2.4+/-0.8 mm, PBL gain of 2.2+/-1.7 mm (25%) and a radiographic bone fill of 3.3+/-2.2 mm. All improvements were statistically significant (p<0.01) but there was no difference between RM and NRM treatments for any of the efficacy variables. The results of this study indicated that there was no clinically significant difference in treatment outcomes following GTR treatment of intrabony defects with citric acid ester softened polylactic acid membranes as compared to ePTFE barriers. The overall mean inter-proximal vertical bone defect fill at 12 months as assessed from intra-oral radiographs was 44% of the original mean defect depth. Thus, no clinically significant difference in treatment outcomes was observed following GTR treatment of intrabony defects with citric acid ester softened polylactic acid membranes or ePTFE barriers.

Thermo-Acidic Pretreatment of Beach Macroalgae from Rügen to Optimize Biomethane Production—Double Benefit with Simultaneous Bioenergy Production and Improvement of Local Beach and Waste Management

PubMed Central

Barbot, Yann Nicolas; Thomsen, Laurenz; Benz, Roland

2015-01-01

Eutrophication is a phenomenon which can rapidly generate masses of marine macroalgae, particularly in areas with high nutrient pollution. Washed ashore, this biomass impairs coastal tourism and negatively affects the coastal ecosystem. The present study evaluates the biochemical methane potential (BMP) of a macroalgae mix (Rügen-Mix, RM (RM = Rügen-Mix)) originating from Rügen, Germany. To improve biomethane recovery, thermo-acidic pretreatment was applied to the biomass prior to biomethanation to disintegrate the biomass macrostructure. Acid hydrolysis was successfully triggered with 0.2 M industry-grade HCl at 80 °C for a 2 h period, increasing biomethane recovery by +39%, with a maximum BMP of 121 mL·g−1 volatile solids (VS). To reduce the necessity for input material, HCl was replaced by the acidic waste product flue gas condensate (FGC). Improved performance was achieved by showing an increase in biomethane recovery of +24% and a maximum BMP of 108 mL·g−1 VS. Continuous anaerobic digestion trials of RM were conducted for three hydraulic retention times, showing the feasibility of monodigestion. The biomethane recovery was 60 mL and 65 mL·g−1 VS·d−1 for thermophilic and mesophilic operation, respectively. The quality of biomethanation performance aligned to the composition of the source material which exhibited a low carbon/nitrogen ratio and an increased concentration of sulfur compounds. PMID:26404327

Thermo-Acidic Pretreatment of Beach Macroalgae from Rügen to Optimize Biomethane Production--Double Benefit with Simultaneous Bioenergy Production and Improvement of Local Beach and Waste Management.

PubMed

Barbot, Yann Nicolas; Thomsen, Laurenz; Benz, Roland

2015-09-03

Eutrophication is a phenomenon which can rapidly generate masses of marine macroalgae, particularly in areas with high nutrient pollution. Washed ashore, this biomass impairs coastal tourism and negatively affects the coastal ecosystem. The present study evaluates the biochemical methane potential (BMP) of a macroalgae mix (Rügen-Mix, RM (RM = Rügen-Mix)) originating from Rügen, Germany. To improve biomethane recovery, thermo-acidic pretreatment was applied to the biomass prior to biomethanation to disintegrate the biomass macrostructure. Acid hydrolysis was successfully triggered with 0.2 M industry-grade HCl at 80 °C for a 2 h period, increasing biomethane recovery by +39%, with a maximum BMP of 121 mL·g(-1) volatile solids (VS). To reduce the necessity for input material, HCl was replaced by the acidic waste product flue gas condensate (FGC). Improved performance was achieved by showing an increase in biomethane recovery of +24% and a maximum BMP of 108 mL·g(-1) VS. Continuous anaerobic digestion trials of RM were conducted for three hydraulic retention times, showing the feasibility of monodigestion. The biomethane recovery was 60 mL and 65 mL·g(-1) VS·d(-1) for thermophilic and mesophilic operation, respectively. The quality of biomethanation performance aligned to the composition of the source material which exhibited a low carbon/nitrogen ratio and an increased concentration of sulfur compounds.

Reading Social wMaps.w

ERIC Educational Resources Information Center

Clements, Millard

1982-01-01

What should social studies teachers be trying to teach students how to do? Every culture provides its members with social "maps" that explain how things are--e.g., school materials, advertisements. Teaching students how to read these social "maps" should be the central task for social studies education. (RM)

The Nuclear Power/Nuclear Weapons Connection.

ERIC Educational Resources Information Center

Totten, Sam; Totten, Martha Wescoat

1985-01-01

Once they have nuclear power, most countries will divert nuclear materials from commercial to military programs. In excerpts from the book "Facing the Danger" (by Totten, S. and M. W., Crossing Press, 1984), five anti-nuclear activists explain how and why they have been addressing the nuclear connection. (RM)

The Controversy over Civic Education.

ERIC Educational Resources Information Center

Kane, Frank

1983-01-01

Because of the unpopularity of the inquiry method, most new government texts are of the straight narrative type. Many educators believe that civics curriculum materials are subject to censorship by special interest groups. Regarding goal achievement, many believe civic education has not trained students to accept their civic responsibilities. (RM)

The Fabrication of (bismuth, LEAD)(2) STRONTIUM(2) CALCIUM(2) COPPER(3) Oxygen(x) Superconductor in Bulk and Tape Forms

NASA Astrophysics Data System (ADS)

Lim, Hanjin

High-T_{rm c}<=ad doped rm Bi_2Sr_2Ca_2Cu _2Cu_3O_{x} (BSCCO 2223) superconductor bulk materials were prepared using conventional powder metallurgy techniques, which were made from precursors having different histories. The ease of formation of superconducting phases was highly dependent on the processing of primitive powder. With the three -powder process that combines three kinds of calcined precursor powders, the formation of the BSCCO superconductor was accelerated and the amount of the secondary phase (e.g., Ca_2CuO_3) was reduced. The critical transition temperature (T _{rm c}) of the superconductor from the three-powder process is higher than that from the one-powder process. In lead-doped BSCCO 2223, positron trapping and annihilation evidently occur in the open BiO double layers rather than in the superconducting CuO_2 layers of the structure. Both positron annihilation parameters (tau_1, tau _2, overlinetau) and Doppler parameters (P, W, P/W) were insensitive to the superconducting transition in this material. This is quite opposite to the case of YBCO and Dy doped YBCO where positron annihilation is sensitive to the superconducting transition. High-T_{rm c} BSCCO superconducting tapes were fabricated using the powder -in-tube (PIT) method that includes heat treatments as well as mechanical processing such as drawing, rolling, and pressing. The highest critical current densities (J _{rm c}) at 5 and 77 K were 5.12 times 10^5 A/cm^2 and 1.77 times 10^4 A/cm^2 , respectively, for the tape sample which was solid state processed at 840^circC with three short sintering steps. J_{ rm c} values at 5 and 77 K of tape samples were 1 and 2 orders of magnitude higher than those of bulk samples, respectively. The preferred orientations of the BSCCO 2212 phase in the tape samples were basal and (1 1 13) textures; for the BSCCO 2223 phase preferred orientations were also basal and (1 1 19) textures. By taking the ratios of the texture coefficients (TCs) for (0 0 1) and (1 1 0) reflections, one can describe the strength of the basal texture for each superconducting phase in both bulk and tape. From these ratios one can say that the best basal texture for the tape BSCCO 2212 was produced by the procedure which included partial melting at 850^circ C for 0.3 h. The best treatment for BSCCO 2223 was the tape sample with solid state processing at 840 ^circC in 10% oxygen.

The Astronomical Almanac Online - Glossary

Science.gov Websites

Astronomical Almanac. Δ A B C D E F G H I J K L M N O P Q R S T U V W X Y Z $\\boldmath{\\Delta {\\rm T}}$: the difference between Terrestrial Time (TT) and Universal Time (UT): $\\Delta {\\rm T} = {\\rm TT} - {\\rm UT}1 $. $\\boldmath{\\Delta {\\rm UT1}}$ (or $\\boldmath{\\Delta {\\rm UT}}$): the value of the difference between

Comparative studies of high performance swimming in sharks I. Red muscle morphometrics, vascularization and ultrastructure.

PubMed

Bernal, D; Sepulveda, C; Mathieu-Costello, O; Graham, J B

2003-08-01

Tunas (family Scombridae) and sharks in the family Lamnidae are highly convergent for features commonly related to efficient and high-performance (i.e. sustained, aerobic) swimming. High-performance swimming by fishes requires adaptations augmenting the delivery, transfer and utilization of O(2) by the red myotomal muscle (RM), which powers continuous swimming. Tuna swimming performance is enhanced by a unique anterior and centrally positioned RM (i.e. closer to the vertebral column) and by structural features (relatively small fiber diameter, high capillary density and greater myoglobin concentration) increasing O(2) flux from RM capillaries to the mitochondria. A study of the structural and biochemical features of the mako shark (Isurus oxyrinchus) RM was undertaken to enable performance-capacity comparisons of tuna and lamnid RM. Similar to tunas, mako RM is positioned centrally and more anterior in the body. Another lamnid, the salmon shark (Lamna ditropis), also has this RM distribution, as does the closely related common thresher shark (Alopias vulpinus; family Alopiidae). However, in both the leopard shark (Triakis semifasciata) and the blue shark (Prionace glauca), RM occupies the position where it is typically found in most fishes; more posterior and along the lateral edge of the body. Comparisons among sharks in this study revealed no differences in the total RM quantity (approximately 2-3% of body mass) and, irrespective of position within the body, RM scaling is isometric in all species. Sharks thus have less RM than do tunas (4-13% of body mass). Relative to published data on other shark species, mako RM appears to have a higher capillary density, a greater capillary-to-fiber ratio and a higher myoglobin concentration. However, mako RM fiber size does not differ from that reported for other shark species and the total volume of mitochondria in mako RM is similar to that reported for other sharks and for tunas. Lamnid RM properties thus suggest a higher O(2) flux capacity than in other sharks; however, lamnid RM aerobic capacity appears to be less than that of tuna RM.

Investigation of extended Y chromosome STR haplotypes in Sardinia.

PubMed

Lacerenza, D; Aneli, S; Di Gaetano, C; Critelli, R; Piazza, A; Matullo, G; Culigioni, C; Robledo, R; Robino, C; Calò, C

2017-03-01

Y-chromosomal variation of selected single nucleotide polymorphisms (SNPs) and 32 short tandem repeat (STR) loci was evaluated in Sardinia in three open population groups (Northern Sardinia, n=40; Central Sardinia, n=56; Southern Sardinia, n=91) and three isolates (Desulo, n=34; Benetutti, n=45, Carloforte, n=42). The tested Y-STRs consisted of Yfiler ® Plus markers and the seven rapidly mutating (RM) loci not included in the YFiler ® Plus kit (DYF399S1, DYF403S1ab, DYF404S1, DYS526ab, DYS547, DYS612, and DYS626). As expected, inclusion of additional Y-STR loci increased haplotype diversity (h), though complete differentiation of male lineages was impossible even by means of RM Y-STRs (h=0.99997). Analysis of molecular variance indicated that the three open populations were fairly homogeneous, whereas signs of genetic heterogeneity could be detected when the three isolates were also included in the analysis. Multidimensional scaling analysis showed that, even for extended haplotypes including RM Y-STR markers, Sardinians were clearly differentiated from populations of the Italian peninsula and Sicily. The only exception was represented by the Carloforte sample that, in accordance with its peculiar population history, clustered with Northern/Central Italian populations. The introduction of extended forensic Y-STR panels, including highly variable RM Y-STR markers, is expected to reduce the impact of population structure on haplotype frequency estimations. However, our results show that the availability of geographically detailed reference databases is still important for the assessment of the evidential value of a Y-haplotype match. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Differential Changes in Hippocampal CaMKII and GluA1 Activity after Memory Training Involving Different Levels of Adaptive Forgetting

ERIC Educational Resources Information Center

Fraize, Nicolas; Hamieh, Al Mahdy; Joseph, Mickael Antoine; Touret, Monique; Parmentier, Regis; Salin, Paul Antoine; Malleret, Gael

2017-01-01

Phosphorylation of CaMKII and AMPA receptor GluA1 subunit has been shown to play a major role in hippocampal-dependent long-term/reference memory (RM) and in the expression of long-term synaptic potentiation (LTP). In contrast, it has been proposed that dephosphorylation of these proteins could be involved in the opposite phenomenon of hippocampal…

Comparison of muscle force production using the Smith machine and free weights for bench press and squat exercises.

PubMed

Cotterman, Michael L; Darby, Lynn A; Skelly, William A

2005-02-01

The Smith machine (SM) (vertical motion of bar on fixed path; fixed-form exercise) and free weights (FWs) (free-form path) are commonly used strength training modes. Exercisers may need to alternate between types of equipment, depending on testing, training, rehabilitation, and/or the exercisers' goals. The purposes of this study were to compare muscle force production for SM and FWs using a 1 repetition maximum (1RM) for the parallel back squat and supine bench press exercises and to predict the 1RM for one mode from 1RM on the other mode. Men (n = 16) and women (n = 16) alternately completed 1RM testing for squat and bench press using SM and FWs. Analyses of variance (type of equipment x sex) and linear regression models were calculated. A significant difference was found between bench press and squat 1RMs for each mode of equipment for all participants. The squat 1RM was greater for the SM than the FWs; conversely, the bench 1RM was greater for FWs than the SM. When sex was considered, bench 1RM for FWs was greater than SM for men and women. The squat 1RM was greater for SM than FWs for women only. The 1RM on one mode of equipment was the best predictor of 1RM for the other mode. For both sexes, the equation SM bench 1RM (in kilograms) = -6.76 + 0.95 (FW bench 1RM) can be used. For women only, SM squat 1RM (in kilograms) = 28.3 + 0.73 (FW squat 1RM). These findings provide equations for converting between SM and FW equipment for training.

Growth performance, blood health, antioxidant status and immune response in red sea bream (Pagrus major) fed Aspergillus oryzae fermented rapeseed meal (RM-Koji).

PubMed

Dossou, Serge; Koshio, Shunsuke; Ishikawa, Manabu; Yokoyama, Saichiro; Dawood, Mahmoud A O; El Basuini, Mohammed F; Olivier, Adissin; Zaineldin, Amr I

2018-04-01

This study evaluated the effects of dietary substitution of fishmeal by graded levels of a blend composed of Aspergillus oryzae fermented rapeseed meal [0% (RM0), 25% (RM25), 50% (RM50), 75% (RM75) and 100% (RM100)] on growth performance, haemato-immunological responses and antioxidative status of Pagrus major (average weight 5.5 ± 0.02 g). After 56 days, growth performances were significantly improved in fish fed RM25 diet compared to control (P < 0.05). Meanwhile, up to 50% replacement of fishmeal did not affect growth performance, feed conversion efficiency, protein efficiency ratio, protein apparent digestibility, protease activity, fish somatic indices and survival compared to control. While blood hematocrit and plasma protein were significantly enhanced in groups fed RM0 and RM25 diets, most of the hematological parameters did not change through the trial except glutamic pyruvate transaminase which was significantly increased in RM75 and RM100 groups and blood cholesterol which was gradually decreased with the increasing level of the blend. Interestingly, feeding fish with RM25 and RM50 diets significantly showed enhanced lysozyme, bactericidal and peroxidase activities and fish fed the same diets showed high resistance against oxidative stress (biological antioxidant potential and reactive oxygen metabolites). Additionally, catalase activity and tolerance against low salinity seawater were higher in fish fed RM25 diet. These findings suggested that, at a moderate level (25% and 50%), substitution of fishmeal by the fermented rapeseed meal promoted growth, nutrient utilization, and exerted immune responses and anti-oxidative effects in red sea bream. Copyright © 2018 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, B.; DuCharme, G.

We present a semi-empirical scaling law for non-resonant ion–atom single charge exchange cross sections for collisions with velocities frommore » $${10}^{7}\\,{\\rm{t}}{\\rm{o}}\\,{10}^{9}\\,\\mathrm{cm}\\,{{\\rm{s}}}^{-1}$$ and ions with positive charge $$q\\lt 8$$. Non-resonant cross sections tend to have a velocity peak at collision velocities $$v\\lesssim 1\\ {\\rm{a}}{\\rm{u}}$$ with exponential decay around this peak. We construct a scaling formula for the location of this peak then choose a functional form for the cross section curve and scale it. The velocity at which the cross section peaks, v m, is proportional to the energy defect of the collision, $${\\rm{\\Delta }}E$$, which we predict with the decay approximation. The value of the cross section maximum is proportional to the charge state q, inversely proportional to the target ionization energy I T, and inversely proportional to v m. For the shape of the cross section curve, we use a function that decays exponentially asymptotically at high and low velocities. We scale this function with parameters $${v}_{{\\rm{m}}},{I}_{{\\rm{T}}},{Z}_{{\\rm{T}}},\\mathrm{and}\\ {Z}_{{\\rm{P}}}$$, where the $${Z}_{{\\rm{T}},{\\rm{P}}}$$ are the target and projectile atomic numbers. In conclusion, for the more than 100 cross section curves that we use to find the scaling rules, the scaling law predicts cross sections within a little over a factor of 2 on average.« less

Tropospheric GOM at the Pic du Midi Observatory-Correcting Bias in Denuder Based Observations.

PubMed

Marusczak, Nicolas; Sonke, Jeroen E; Fu, Xuewu; Jiskra, Martin

2017-01-17

Gaseous elemental mercury (GEM, Hg) emissions are transformed to divalent reactive Hg (RM) forms throughout the troposphere and stratosphere. RM is often operationally quantified as the sum of particle bound Hg (PBM) and gaseous oxidized Hg (GOM). The measurement of GOM and PBM is challenging and under mounting criticism. Here we intercompare six months of automated GOM and PBM measurements using a Tekran (TK) KCl-coated denuder and quartz regenerable particulate filter method (GOM TK , PBM TK , and RM TK ) with RM CEM collected on cation exchange membranes (CEMs) at the high altitude Pic du Midi Observatory. We find that RM TK is systematically lower by a factor of 1.3 than RM CEM . We observe a significant relationship between GOM TK (but not PBM TK ) and Tekran flush TK blanks suggesting significant loss (36%) of labile GOM TK from the denuder or inlet. Adding the flush TK blank to RM TK results in good agreement with RM CEM (slope = 1.01, r 2 = 0.90) suggesting we can correct bias in RM TK and GOM TK . We provide a bias corrected (*) Pic du Midi data set for 2012-2014 that shows GOM* and RM* levels in dry free tropospheric air of 198 ± 57 and 229 ± 58 pg m -3 which agree well with in-flight observed RM and with model based GOM and RM estimates.

Extraction of $$\\sin^2\\theta^{\\rm lept}_{\\rm eff}$$ and indirect measurement of $$m_w$$ from the 9 fb$$^{-1}$$ full run ii sample of $$\\mu^+\\mu^-$$ events at cdf

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bodek, A.

2014-09-19

We report on the extraction ofmore » $$\\sin^2\\theta^{\\rm lept}_{\\rm eff}$$ and indirect measurement of the mass of the W boson from the forward-backward asymmetry of $$\\mu^+\\mu^-$$ events in the $Z$ boson mass region. The data sample collected by the CDF detector corresponds to the full 9 fb$$^{-1}$$ run II sample. We measure $$\\sin^2 \\theta^{\\rm lept}_{\\rm eff} = 0.2315 \\pm 0.0010$$,$$ \\sin^2 \\theta_W = 0.2233 \\pm 0.0009$$ and $$M_W ({\\rm indirect}) = 80.365 \\pm 0.047 \\;{\\rm GeV}/c^2$$, where each uncertainty includes both statistical and systematic contributions.« less

Effects of temperature on power output and contraction kinetics in the locomotor muscle of the regionally endothermic common thresher shark (Alopias vulpinus).

PubMed

Donley, Jeanine M; Sepulveda, Chugey A; Aalbers, Scott A; McGillivray, David G; Syme, Douglas A; Bernal, Diego

2012-10-01

The common thresher shark (Alopias vulpinus) is a pelagic species with medially positioned red aerobic swimming musculature (RM) and regional RM endothermy. This study tested whether the contractile characteristics of the RM are functionally similar along the length of the body and assessed how the contractile properties of the common thresher shark compare with those of other sharks. Contractile properties of the RM were examined at 8, 16 and 24 °C from anterior and posterior axial positions (0.4 and 0.6 fork length, respectively) using the work loop technique. Experiments were performed to determine whether the contractile properties of the RM are similar along the body of the common thresher shark and to document the effects of temperature on muscle power. Axial differences in contractile properties of RM were found to be small or absent. Isometric twitch kinetics of RM were ~fivefold slower than those of white muscle, with RM twitch durations of about 1 s at 24 °C and exceeding 5 s at 8 °C, a Q(10) of nearly 2.5. Power increased approximately tenfold with the 16 °C increase in temperature, while the cycle frequency for maximal power only increased from about 0.5-1.0 Hz over this temperature range. These data support the hypothesis that the RM is functionally similar along the body of the common thresher shark and corroborate previous findings from shark species both with and without medial RM. While twitch kinetics suggest the endothermic RM is not unusually temperature sensitive, measures of power suggest that the RM is not well suited to function at cool temperatures. The cycle frequency at which power is maximized appeared relatively insensitive to temperature in RM, which may reflect the relatively cooler temperature of the thresher RM compared to that observed in lamnid sharks as well as the relatively slow RM phenotype in these large fish.

Stability and instability of hydromagnetic Taylor-Couette flows

NASA Astrophysics Data System (ADS)

Rüdiger, Günther; Gellert, Marcus; Hollerbach, Rainer; Schultz, Manfred; Stefani, Frank

2018-04-01

Decades ago S. Lundquist, S. Chandrasekhar, P. H. Roberts and R. J. Tayler first posed questions about the stability of Taylor-Couette flows of conducting material under the influence of large-scale magnetic fields. These and many new questions can now be answered numerically where the nonlinear simulations even provide the instability-induced values of several transport coefficients. The cylindrical containers are axially unbounded and penetrated by magnetic background fields with axial and/or azimuthal components. The influence of the magnetic Prandtl number Pm on the onset of the instabilities is shown to be substantial. The potential flow subject to axial fields becomes unstable against axisymmetric perturbations for a certain supercritical value of the averaged Reynolds number Rm bar =√{ Re ṡ Rm } (with Re the Reynolds number of rotation, Rm its magnetic Reynolds number). Rotation profiles as flat as the quasi-Keplerian rotation law scale similarly but only for Pm ≫ 1 while for Pm ≪ 1 the instability instead sets in for supercritical Rm at an optimal value of the magnetic field. Among the considered instabilities of azimuthal fields, those of the Chandrasekhar-type, where the background field and the background flow have identical radial profiles, are particularly interesting. They are unstable against nonaxisymmetric perturbations if at least one of the diffusivities is non-zero. For Pm ≪ 1 the onset of the instability scales with Re while it scales with Rm bar for Pm ≫ 1. Even superrotation can be destabilized by azimuthal and current-free magnetic fields; this recently discovered nonaxisymmetric instability is of a double-diffusive character, thus excluding Pm = 1. It scales with Re for Pm → 0 and with Rm for Pm → ∞. The presented results allow the construction of several new experiments with liquid metals as the conducting fluid. Some of them are described here and their results will be discussed together with relevant diversifications of the magnetic instability theory including nonlinear numerical studies of the kinetic and magnetic energies, the azimuthal spectra and the influence of the Hall effect.

High-Temperature High-Current Superconductors: Preparation, Structure, Superconducting Properties, and Flux-Pinning Mechanisms

NASA Astrophysics Data System (ADS)

Hu, Shouxiang

In bulk high-T_{rm c } superconductors, weak links at the grain boundaries and weak flux pinning are the two major causes of low critical current density (J_{ rm c}) at 77 K. In the present study, various processes designed and developed to address these problems are discussed. The novel pressurized-partial -melt-growth process, which leads to a relatively large improvement in the microstructure as well as in the superconducting properties of bulk Y-Ba-Cu-O superconductors, is described. The effects of introducing foreign elements to serve as pinning centers are reported, and the associated anomalous superconducting phenomena are explained on the basis of a detailed study of basic pinning mechanisms related to the presence of small defects. It is demonstrated that in certain cases the pinning force induced by the compression of the vortex line may be comparable to, or even larger than, the usually recognized pinning force due to the condensation energy. Studies of the pinning mechanism corresponding to large boundary defects show that boundary defects associated with certain non-superconducting inclusions and isolated weak links have a very positive role in the enhancement of both the critical current density and the effective activation energy for flux creep. However, even optimized theoretical estimates show that it will be difficult to reach J_ {rm c} values of 5 times 10^5 A/cm^2 at 77 K and H = 1 T by increasing the number of Y_2BaCuO inclusions alone. Although even higher J_{rm c} values may be achieved by introducing other types of defects using alternative approaches such as irradiation, and, probably, chemical doping, the presence of large amount of boundary defects is very important in causing a large increase in the effective activation energy for flux creep. Also studied are the anisotropic electromagnetic features of the grain-aligned YBa_2Cu _3O_{rm x} bulk superconductors. The development of novel processing methods guided by improved understanding of the basic mechanisms involved opens the way for the preparation of high-quality bulk high-T_{rm c} superconducting materials for a wide variety of applications.

Thermal Property Engineering: Exploiting the Properties of Ceramic Nanocomposites

DTIC Science & Technology

2018-03-01

fluorescence peaks were too weak to observe. The fact that Nd peaks were observed, after only actively doping Er into the material, was unexpected but not...Shumbula PM, Ngila JC, Sikhwivhilu LM, Moutloali RM. Effects of precipitation temperature on nanoparticle surface area and antibacterial behaviour of Mg(OH

49 CFR 178.705 - Standards for metal IBCs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... a frame with a metal lattice-work casing. (c) Construction requirements for metal IBCs are as... used on fracture under tensile stress (Rm × Ao = 10,000 × 145; if tensile strength is in U.S. Standard...

A Software Tool for the Rapid Analysis of the Sintering Behavior of Particulate Bodies

DTIC Science & Technology

2017-11-01

bounded by a region that the user selects via cross hairs . Future plot analysis features, such as more complicated curve fitting and modeling functions...German RM. Grain growth behavior of tungsten heavy alloys based on the master sintering curve concept. Metallurgical and Materials Transactions A

The MMWR: A Resource for Teaching Medical Geography.

ERIC Educational Resources Information Center

Pyle, Gerald F.

1984-01-01

Accounts from the Morbidity and Mortality Weekly Report, published by the Centers for Disease Control in Atlanta, Georgia can be integrated with materials from related scientific sources to help college students develop an understanding of the emerging geography of recently discovered diseases. Legionnaires' disease is used as an example. (RM)

Perspectives and Prejudices: Writing on the Vietnam War.

ERIC Educational Resources Information Center

Soper, Steven P.

1984-01-01

The seven books analyzed here reflect clear and often exasperating prejudices. However, when taken as a whole, their individual perspectives yield a wealth of information, material, and ideas that can increase understanding of both the complexities of America's involvement in Vietnam and the questions surrounding such involvement. (RM)

The Role of the Universities in the Current Scientific and Technological Revolution in the USSR

ERIC Educational Resources Information Center

Nuzhin, M. T.

1975-01-01

The scientific and technological revolution is making progressive changes in the material conditions of economic production in Russia and is actively influencing the development and improvement of education. The influence of university education on the socioeconomic process is discussed. (Author/RM)

Laboratory measurements of the K-shell transition energies in L-shell ions of Si and S [Energy measurements of K-shell transitions in L-shell ions of Si and S

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hell, Natalie; Brown, G. V.; Wilms, J.

We have measured the energies of the strongest 1s–2more » $${\\ell }\\ ({\\ell }={\\rm{s}},{\\rm{p}})$$ transitions in He- through Ne-like silicon and sulfur ions to an accuracy of $$\\lt 1\\,\\mathrm{eV}$$ using the Lawrence Livermore National Laboratory's electron beam ion traps, EBIT-I and SuperEBIT, and the NASA/GSFC EBIT Calorimeter Spectrometer (ECS). We identify and measure the energies of 18 and 21 X-ray features from silicon and sulfur, respectively. The results are compared to new Flexible Atomic Code calculations and to semi-relativistic Hartree–Fock calculations by Palmeri et al. (2008). These results will be especially useful for wind diagnostics in high-mass X-ray binaries, such as Vela X-1 and Cygnus X-1, where high-resolution spectral measurements using Chandra's high-energy transmission grating has made it possible to measure Doppler shifts of $$100\\,\\mathrm{km}\\,{{\\rm{s}}}^{-1}$$. The accuracy of our measurements is consistent with that needed to analyze Chandra observations, exceeding Chandra's $$100\\,\\mathrm{km}\\,{{\\rm{s}}}^{-1}$$ limit. Hence, the results presented here not only provide benchmarks for theory, but also accurate rest energies that can be used to determine the bulk motion of material in astrophysical sources. Finally, we show the usefulness of our results by applying them to redetermine Doppler shifts from Chandra observations of Vela X-1.« less

Laboratory measurements of the K-shell transition energies in L-shell ions of Si and S [Energy measurements of K-shell transitions in L-shell ions of Si and S

DOE PAGES

Hell, Natalie; Brown, G. V.; Wilms, J.; ...

2016-10-04

We have measured the energies of the strongest 1s–2more » $${\\ell }\\ ({\\ell }={\\rm{s}},{\\rm{p}})$$ transitions in He- through Ne-like silicon and sulfur ions to an accuracy of $$\\lt 1\\,\\mathrm{eV}$$ using the Lawrence Livermore National Laboratory's electron beam ion traps, EBIT-I and SuperEBIT, and the NASA/GSFC EBIT Calorimeter Spectrometer (ECS). We identify and measure the energies of 18 and 21 X-ray features from silicon and sulfur, respectively. The results are compared to new Flexible Atomic Code calculations and to semi-relativistic Hartree–Fock calculations by Palmeri et al. (2008). These results will be especially useful for wind diagnostics in high-mass X-ray binaries, such as Vela X-1 and Cygnus X-1, where high-resolution spectral measurements using Chandra's high-energy transmission grating has made it possible to measure Doppler shifts of $$100\\,\\mathrm{km}\\,{{\\rm{s}}}^{-1}$$. The accuracy of our measurements is consistent with that needed to analyze Chandra observations, exceeding Chandra's $$100\\,\\mathrm{km}\\,{{\\rm{s}}}^{-1}$$ limit. Hence, the results presented here not only provide benchmarks for theory, but also accurate rest energies that can be used to determine the bulk motion of material in astrophysical sources. Finally, we show the usefulness of our results by applying them to redetermine Doppler shifts from Chandra observations of Vela X-1.« less

Greater Neural Adaptations following High- vs. Low-Load Resistance Training

PubMed Central

Jenkins, Nathaniel D. M.; Miramonti, Amelia A.; Hill, Ethan C.; Smith, Cory M.; Cochrane-Snyman, Kristen C.; Housh, Terry J.; Cramer, Joel T.

2017-01-01

We examined the neuromuscular adaptations following 3 and 6 weeks of 80 vs. 30% one repetition maximum (1RM) resistance training to failure in the leg extensors. Twenty-six men (age = 23.1 ± 4.7 years) were randomly assigned to a high- (80% 1RM; n = 13) or low-load (30% 1RM; n = 13) resistance training group and completed leg extension resistance training to failure 3 times per week for 6 weeks. Testing was completed at baseline, 3, and 6 weeks of training. During each testing session, ultrasound muscle thickness and echo intensity, 1RM strength, maximal voluntary isometric contraction (MVIC) strength, and contractile properties of the quadriceps femoris were measured. Percent voluntary activation (VA) and electromyographic (EMG) amplitude were measured during MVIC, and during randomly ordered isometric step muscle actions at 10–100% of baseline MVIC. There were similar increases in muscle thickness from Baseline to Week 3 and 6 in the 80 and 30% 1RM groups. However, both 1RM and MVIC strength increased from Baseline to Week 3 and 6 to a greater degree in the 80% than 30% 1RM group. VA during MVIC was also greater in the 80 vs. 30% 1RM group at Week 6, and only training at 80% 1RM elicited a significant increase in EMG amplitude during MVIC. The peak twitch torque to MVIC ratio was also significantly reduced in the 80%, but not 30% 1RM group, at Week 3 and 6. Finally, VA and EMG amplitude were reduced during submaximal torque production as a result of training at 80% 1RM, but not 30% 1RM. Despite eliciting similar hypertrophy, 80% 1RM improved muscle strength more than 30% 1RM, and was accompanied by increases in VA and EMG amplitude during maximal force production. Furthermore, training at 80% 1RM resulted in a decreased neural cost to produce the same relative submaximal torques after training, whereas training at 30% 1RM did not. Therefore, our data suggest that high-load training results in greater neural adaptations that may explain the disparate increases in muscle strength despite similar hypertrophy following high- and low-load training programs. PMID:28611677

Semi-empirical scaling for ion–atom single charge exchange cross sections in the intermediate velocity regime

DOE PAGES

Friedman, B.; DuCharme, G.

2017-05-11

We present a semi-empirical scaling law for non-resonant ion–atom single charge exchange cross sections for collisions with velocities frommore » $${10}^{7}\\,{\\rm{t}}{\\rm{o}}\\,{10}^{9}\\,\\mathrm{cm}\\,{{\\rm{s}}}^{-1}$$ and ions with positive charge $$q\\lt 8$$. Non-resonant cross sections tend to have a velocity peak at collision velocities $$v\\lesssim 1\\ {\\rm{a}}{\\rm{u}}$$ with exponential decay around this peak. We construct a scaling formula for the location of this peak then choose a functional form for the cross section curve and scale it. The velocity at which the cross section peaks, v m, is proportional to the energy defect of the collision, $${\\rm{\\Delta }}E$$, which we predict with the decay approximation. The value of the cross section maximum is proportional to the charge state q, inversely proportional to the target ionization energy I T, and inversely proportional to v m. For the shape of the cross section curve, we use a function that decays exponentially asymptotically at high and low velocities. We scale this function with parameters $${v}_{{\\rm{m}}},{I}_{{\\rm{T}}},{Z}_{{\\rm{T}}},\\mathrm{and}\\ {Z}_{{\\rm{P}}}$$, where the $${Z}_{{\\rm{T}},{\\rm{P}}}$$ are the target and projectile atomic numbers. In conclusion, for the more than 100 cross section curves that we use to find the scaling rules, the scaling law predicts cross sections within a little over a factor of 2 on average.« less

Characterization and application of enterocin RM6, a bacteriocin from Enterococcus faecalis.

PubMed

Huang, En; Zhang, Liwen; Chung, Yoon-Kyung; Zheng, Zuoxing; Yousef, Ahmed E

2013-01-01

Use of bacteriocins in food preservation has received great attention in recent years. The goal of this study is to characterize enterocin RM6 from Enterococcus faecalis OSY-RM6 and investigate its efficacy against Listeria monocytogenes in cottage cheese. Enterocin RM6 was purified from E. faecalis culture supernatant using ion exchange column, multiple C18-silica cartridges, followed by reverse-phase high-performance liquid chromatography. The molecular weight of enterocin RM6 is 7145.0823 as determined by mass spectrometry (MS). Tandem mass spectrometry (MS/MS) analysis revealed that enterocin RM6 is a 70-residue cyclic peptide with a head-to-tail linkage between methionine and tryptophan residues. The peptide sequence of enterocin RM6 was further confirmed by sequencing the structural gene of the peptide. Enterocin RM6 is active against Gram-positive bacteria, including L. monocytogenes, Bacillus cereus, and methicillin-resistant Staphylococcus aureus (MRSA). Enterocin RM6 (final concentration in cottage cheese, 80 AU/mL) caused a 4-log reduction in population of L. monocytogenes inoculated in cottage cheese within 30 min of treatment. Therefore, enterocin RM6 has potential applications as a potent antimicrobial peptide against foodborne pathogens in food.

Characterization and Application of Enterocin RM6, a Bacteriocin from Enterococcus faecalis

PubMed Central

Chung, Yoon-Kyung; Yousef, Ahmed E.

2013-01-01

Use of bacteriocins in food preservation has received great attention in recent years. The goal of this study is to characterize enterocin RM6 from Enterococcus faecalis OSY-RM6 and investigate its efficacy against Listeria monocytogenes in cottage cheese. Enterocin RM6 was purified from E. faecalis culture supernatant using ion exchange column, multiple C18-silica cartridges, followed by reverse-phase high-performance liquid chromatography. The molecular weight of enterocin RM6 is 7145.0823 as determined by mass spectrometry (MS). Tandem mass spectrometry (MS/MS) analysis revealed that enterocin RM6 is a 70-residue cyclic peptide with a head-to-tail linkage between methionine and tryptophan residues. The peptide sequence of enterocin RM6 was further confirmed by sequencing the structural gene of the peptide. Enterocin RM6 is active against Gram-positive bacteria, including L. monocytogenes, Bacillus cereus, and methicillin-resistant Staphylococcus aureus (MRSA). Enterocin RM6 (final concentration in cottage cheese, 80 AU/mL) caused a 4-log reduction in population of L. monocytogenes inoculated in cottage cheese within 30 min of treatment. Therefore, enterocin RM6 has potential applications as a potent antimicrobial peptide against foodborne pathogens in food. PMID:23844357

Selective effects of different fatigue protocols on the function of upper body muscles assessed through the force-velocity relationship.

PubMed

García-Ramos, Amador; Torrejón, Alejandro; Feriche, Belén; Morales-Artacho, Antonio J; Pérez-Castilla, Alejandro; Padial, Paulino; Jaric, Slobodan

2018-02-01

This study explored the feasibility of the force-velocity relationship (F-V) to detect the acute effects of different fatigue protocols on the selective changes of the maximal capacities of upper body muscles to produce force, velocity, and power. After determining the bench press one-repetition maximum (1RM), participants' F-V relationships were assessed during the bench press throw exercise on five separate sessions after performing one of the following fatiguing protocols: 60%1RM failure, 60%1RM non-failure, 80%1RM failure, 80%1RM non-failure, and no-fatigue. In the non-failure protocols, participants performed half the maximum number of repetitions than in their respective failure protocols. The main findings revealed that (1) all F-V relationships were highly linear (median r = 0.997 and r = 0.982 for averaged across participants and individual data, respectively), (2) the fatiguing protocols were ranked based on the magnitude of power loss as follows: 60%1RM failure > 80%1RM failure > 60%1RM non-failure > 80%1RM non-failure, while (3) the assessed maximum force and velocity outputs showed a particularly prominent reduction in the protocols based on the lowest and highest levels of fatigue (i.e., 80%1RM non-failure and 60%1RM failure), respectively. The results support the use of F-V to assess the effects of fatigue on the distinctive capacities of the muscles to produce force, velocity, and power output while performing multi-joint tasks, while the assessed maximum force and velocity capacities showed a particularly prominent reduction in the protocols based on the lowest and highest levels of fatigue (i.e., 80%1RM non-failure and 60%1RM failure), respectively.

RM-CLEAN: RM spectra cleaner

NASA Astrophysics Data System (ADS)

Heald, George

2017-08-01

RM-CLEAN reads in dirty Q and U cubes, generates rmtf based on the frequencies given in an ASCII file, and cleans the RM spectra following the algorithm given by Brentjens (2007). The output cubes contain the clean model components and the CLEANed RM spectra. The input cubes must be reordered with mode=312, and the output cubes will have the same ordering and thus must be reordered after being written to disk. RM-CLEAN runs as a MIRIAD (ascl:1106.007) task and a Python wrapper is included with the code.

Development of 1RM Prediction Equations for Bench Press in Moderately Trained Men.

PubMed

Macht, Jordan W; Abel, Mark G; Mullineaux, David R; Yates, James W

2016-10-01

Macht, JW, Abel, MG, Mullineaux, DR, and Yates, JW. Development of 1RM prediction equations for bench press in moderately trained men. J Strength Cond Res 30(10): 2901-2906, 2016-There are a variety of established 1 repetition maximum (1RM) prediction equations, however, very few prediction equations use anthropometric characteristics exclusively or in part, to estimate 1RM strength. Therefore, the purpose of this study was to develop an original 1RM prediction equation for bench press using anthropometric and performance characteristics in moderately trained male subjects. Sixty male subjects (21.2 ± 2.4 years) completed a 1RM bench press and were randomly assigned a load to complete as many repetitions as possible. In addition, body composition, upper-body anthropometric characteristics, and handgrip strength were assessed. Regression analysis was used to develop a performance-based 1RM prediction equation: 1RM = 1.20 repetition weight + 2.19 repetitions to fatigue - 0.56 biacromial width (cm) + 9.6 (R = 0.99, standard error of estimate [SEE] = 3.5 kg). Regression analysis to develop a nonperformance-based 1RM prediction equation yielded: 1RM (kg) = 0.997 cross-sectional area (CSA) (cm) + 0.401 chest circumference (cm) - 0.385%fat - 0.185 arm length (cm) + 36.7 (R = 0.81, SEE = 13.0 kg). The performance prediction equations developed in this study had high validity coefficients, minimal mean bias, and small limits of agreement. The anthropometric equations had moderately high validity coefficient but larger limits of agreement. The practical applications of this study indicate that the inclusion of anthropometric characteristics and performance variables produce a valid prediction equation for 1RM strength. In addition, the CSA of the arm uses a simple nonperformance method of estimating the lifter's 1RM. This information may be used to predict the starting load for a lifter performing a 1RM prediction protocol or a 1RM testing protocol.

Strength tests for elite rowers: low- or high-repetition?

PubMed

Lawton, Trent W; Cronin, John B; McGuigan, Michael R

2014-01-01

The purpose of this project was to evaluate the utility of low- and high-repetition maximum (RM) strength tests used to assess rowers. Twenty elite heavyweight males (age 23.7 ± 4.0 years) performed four tests (5 RM, 30 RM, 60 RM and 120 RM) using leg press and seated arm pulling exercise on a dynamometer. Each test was repeated on two further occasions; 3 and 7 days from the initial trial. Per cent typical error (within-participant variation) and intraclass correlation coefficients (ICCs) were calculated using log-transformed repeated-measures data. High-repetition tests (30 RM, 60 RM and 120 RM), involving seated arm pulling exercise are not recommended to be included in an assessment battery, as they had unsatisfactory measurement precision (per cent typical error > 5% or ICC < 0.9). Conversely, low-repetition tests (5 RM) involving leg press and seated arm pulling exercises could be used to assess elite rowers (per cent typical error ≤ 5% and ICC ≥ 0.9); however, only 5 RM leg pressing met criteria (per cent typical error = 2.7%, ICC = 0.98) for research involving small samples (n = 20). In summary, low-repetition 5 RM strength testing offers greater utility as assessments of rowers, as they can be used to measure upper- and lower-body strength; however, only the leg press exercise is recommended for research involving small squads of elite rowers.

Broadband Photometric Reverberation Mapping Analysis on SDSS-RM and Stripe 82 Quasars

NASA Astrophysics Data System (ADS)

Zhang, Haowen; Yang, Qian; Wu, Xuebing; Shen, Yue

2018-01-01

We extended the broadband photometric reverberation mapping (PRM) code, JAVELIN and test the availability to get broad line region (BLR) time delays that are consistent with spectroscopic reverberation mapping (SRM) projects. Broadband light curves of SDSS-RM quasars produced by convolution with system transmission curve were used in the test. We find that under similar sampling conditions (evenly and frequently sampled), the key factor determining whether the broadband PRM code can yield lags consistent with spectroscopic projects is the flux ratio of line to the reference continuum, which is in line with the findings in Zu et al. (2016). We further find a crucial line-to-continuum flux ratio, above which the mean of the ratios between the lags from PRM and SRM becomes closer to unity, and the scatter is pronouncedly reduced. Based on this flux ratio criteria, we selected some of the quasars from Hernitschek et al. (2015) and carry out broadband PRM on this subset. The performance of damped random walking (DRW) model and power-law (PL) structure function model on broadband PRM are compared using mock light curves with high, even cadences and low, uneven ones, respectively. We find that DRW model performs better in carrying out broadband PRM than PL model both for high and low cadence light curves with other data qualities similar to SDSS-RM quasars.

Effect of 1 Repetition Maximum, 80% Repetition Maximum, and 50% Repetition Maximum Strength Exercise in Trained Individuals on Variations in Plasma Redox Biomarkers.

PubMed

Polotow, Tatiana G; Souza-Junior, Tácito P; Sampaio, Ricardo C; Okuyama, Alexandre R; Ganini, Douglas; Vardaris, Cristina V; Alves, Ragami C; McAnulty, Steven R; Barros, Marcelo P

2017-09-01

Polotow, TG, Souza-Junior, TP, Sampaio, RC, Okuyama, AR, Ganini, D, Vardaris, CV, Alves, RC, McAnulty, SR, and Barros, MP. Effect of 1RM, 80%RM, and 50%RM strength exercise in trained individuals on variations in plasma redox biomarkers. J Strength Cond Res 31(9): 2489-2497, 2017-For decades, scientists have examined the participation of oxygen/nitrogen species in anaerobic-like exercises, especially weightlifting and resistance exercises. The balance between the production of oxyradicals and antioxidant responses during anaerobic-like exercises is essential to assure adaptation to the physiological benefits of strength training and to prevent chronic harmful effects. The aim of this study is to examine the hypothesis that different weight loads (1 repetition maximum (RM), 80%RM, and 50%RM) lifted until exhaustion could impose distinct oxidative insults and elicit diverse antioxidant responses in plasma of young trained subjects. Glucose (+10%), lactate (+65%), urea (+30%), free iron (+65%), reduced/oxidized glutathione (+14 and +23%, respectively), and xanthine oxidase activity (2.2-fold) significantly increased after the 1RM test, whereas plasma antioxidant capacity dropped by 37%. When lower weight loads were applied (80%RM and 50%RM tests), heme-iron (+15 and +20%, respectively) became the prevalent pro-oxidant, although glutathione responses were only detected after 80%RM (+14%). Lactate concentration in plasma continuously increased, by 2.9-fold (80%RM) and 3.6-fold higher (50%RM test). We demonstrated that 1RM tests significantly diminish the antioxidant capacity of plasma because of iron overload, whereas 80%RM tests require higher involvement of glutathione molecules to counteract heme-iron oxidative insult. Mild redox imbalances promoted by heme-iron were found in plasma after 50%RM. Although we did not observe overall changes in muscle damage in young trained subjects, we cannot exclude the need for specific antioxidant supplementation depending on the strength protocols applied, especially for less responsive groups, such as sedentary and elderly populations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tripathi, Anjali; Winn, Joshua N.; De Kleer, Katherine R.

We present new spectroscopic and photometric observations of the transiting exoplanetary system WASP-3. Spectra obtained during two separate transits exhibit the Rossiter-McLaughlin (RM) effect and allow us to estimate the sky-projected angle between the planetary orbital axis and the stellar rotation axis, {lambda} = 3.3{sup +2.5}{sub -4.4} deg. This alignment between the axes suggests that WASP-3b has a low orbital inclination relative to the equatorial plane of its parent star. During our first night of spectroscopic measurements, we observed an unexpected redshift briefly exceeding the expected sum of the orbital and RM velocities by 140 m s{sup -1}. This anomalymore » could represent the occultation of material erupting from the stellar photosphere, although it is more likely to be an artifact caused by moonlight scattered into the spectrograph.« less

Vortex Flux Pinning in Type-Ii Superconductors

NASA Astrophysics Data System (ADS)

Hasan, Mohammad-Khair A. M.

1995-01-01

Rotational magnetization vector measurements on polycrystalline samples of rm YBa_2Cu _3O_7 (YBCO) and (Ba, K)BiO _3 at various fixed fields (H) and temperatures (T) reveal that the vortex flux density (B) in a rotational state consists of a component B_{rm R}, which rotates rigidly with sample rotation, and a B_{rm F} component, which stays at a fixed frictional angle (theta _{rm F}) relative to H. Also, B_{rm R} decreases and ultimately vanishes with increasing H, while B _{rm F} grows monotonically, implying that the vortex pinning strength have a broad distribution. This has been confirmed by the measurements on YBCO of the remanent flux density B^ {rm rm} which can be decomposed analogously into B_{R} ^{} and B_ {F}^{} at angle theta_{F}^{} relative to H. The quantity Hsin theta_{rm F},, which at equilibrium equals tau_{rm p}/mu (the average pinning torque per vortex of moment mu) decreases with increasing high H. This result and the distribution in the strength of the pinning are shown to be consistent with the collective pinning process of vortex bundling. At fixed H, tau_{rm p} decreases rapidly with increasing T, varying approximately as T^{-0.8} for both samples. For polycrystalline YBCO at 4.2 K, B_ {rm R} and B_{ rm F} are found to relax differently with time. The negative creep sign of B_ {rm R} indicates that the number of rotational vortices decreases with time, whereas B _{rm F} shows a positive creep with a negative change in theta_ {rm F}, which indicates that more frictional vortices enter the sample with a tendency of alignment in the direction of H. For grain-oriented YBCO at 4.2 K, the vortex creep measurements of B along the c-axis at different fields showed that: whenever the hysteretic changes of H are reversed in sign, the vortex flux creep (dB/dlogt) decreases very rapidly to zero, where it lingers before changing sign. At the same turning values of H, (dB/dH) also goes to zero. These properties are attributable to the reversals of the vortex motion which occur at the turning values of H and cause a reversal of frictional pinning forces.

Remote Monitoring of Cardiac Implantable Electronic Devices (CIED)

PubMed Central

Zeitler, Emily P.; Piccini, Jonathan P.

2016-01-01

With increasing indications and access to cardiac implantable electronic devices (CIEDs) worldwide, the number of patients needing CIED follow up continues to rise. In parallel, the technology available for managing these devices has advanced considerably. In this setting, remote monitoring (RM) has emerged as a complement to routine in-office care. Rigorous studies, randomized and otherwise, have demonstrated advantages to CIED patient management systems which incorporates RM resulting in authoritative guidelines from relevant professional societies recommending RM for all eligible patients. In addition to clinical benefits, CIED management programs that include RM have been shown to be cost effective and associated with high patient satisfaction. Finally, RM programs hold promise for the future of CIED research in light of the massive data collected through RM databases converging with unprecedented computational capability. This review outlines the available data associated with clinical outcomes in patients managed with RM with an emphasis on randomized trials; the impact of RM on patient satisfaction, cost-effectiveness and healthcare utilization; and possible future directions for the use of RM in clinical practice and research. PMID:27134007

Shock front distortion and Richtmyer-Meshkov-type growth caused by a small preshock nonuniformity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Velikovich, A. L.; Wouchuk, J. G.; Huete Ruiz de Lira, C.

The response of a shock front to small preshock nonuniformities of density, pressure, and velocity is studied theoretically and numerically. These preshock nonuniformities emulate imperfections of a laser target, due either to its manufacturing, like joints or feeding tubes, or to preshock perturbation seeding/growth, as well as density fluctuations in foam targets, ''thermal layers'' near heated surfaces, etc. Similarly to the shock-wave interaction with a small nonuniformity localized at a material interface, which triggers a classical Richtmyer-Meshkov (RM) instability, interaction of a shock wave with periodic or localized preshock perturbations distributed in the volume distorts the shape of the shockmore » front and can cause a RM-type instability growth. Explicit asymptotic formulas describing distortion of the shock front and the rate of RM-type growth are presented. These formulas are favorably compared both to the exact solutions of the corresponding initial-boundary-value problem and to numerical simulations. It is demonstrated that a small density modulation localized sufficiently close to a flat target surface produces the same perturbation growth as an 'equivalent' ripple on the surface of a uniform target, characterized by the same initial areal mass modulation amplitude.« less

Fabrication of CuO-doped catalytic material containing zeolite synthesized from red mud and rice husk ash for CO oxidation

NASA Astrophysics Data System (ADS)

Hieu Do Thi, Minh; Thinh Tran, Quoc; Nguyen, Tri; Van Nguyen Thi, Thuy; Huynh, Ky Phuong Ha

2018-06-01

In this study a series of the CuO-doped materials containing zeolite with varying CuO contents were synthesized from red mud (RM) and rice husk ash (RHA). The rice husk ash/red mud with the molar ratio of , and being 1.8, 2.5 and 60, respectively, were maintained during the synthetic process of materials. The characteristic structure samples were analyzed by x-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscope (TEM), Brunauer–Emmett–Teller (BET) surface area and H2 temperature program reduction (H2-TPR). The catalytic activity of samples was evaluated in CO oxidation reaction in a microflow reactor at temperature range 200 °C–350 °C. The obtained results showed that all synthetic samples there exist the A-type zeolites with the average crystal size of 15–20 nm, the specific surface area of , and pore volume of . The material synthesized from RM and RHA with the zeolite structure (ZRM, undoped CuO) could also oxidize CO completely at 350 °C, and its activity was increase significantly when doped with CuO. CuO-doped materials with the zeolite structure exhibited excellent catalytic activity in CO oxidation. The ZRM sample loading 5 wt% CuO with particle nanosize about 10–30 nm was the best one for CO oxidation with complete conversion temperature at 275 °C.

Ectopic pregnancy in women with recurrent miscarriage.

PubMed

Ticconi, Carlo; Capogna, Maria V; Martelli, Federica; Borelli, Barbara; Bruno, Valentina; Ergasti, Raffaella; Sorge, Roberto; Piccione, Emilio; Pietropolli, Adalgisa

2018-05-01

The aim of this study was to investigate the possible association between recurrent miscarriage (RM) and ectopic pregnancy (EP). In this case-control retrospective study, the clinical cards of women followed as outpatients in the RM and low-risk pregnancy offices of the Obstetrics and Gynecology Unit at the Policlinico Tor Vergata University Hospital were carefully reviewed for the occurrence of EP. Overall, 598 women with RM and 2043 normal women without RM (controls) were included in the study. Among these women, 4974 pregnancies were analyzed, in which 2028 miscarriages occurred. The EP rate (3.51%) was significantly higher in RM than in control women (1.51%) [odds ratio = 2.31 (95% confidence interval: 2.3-2.4)]; it was particularly high in women with primary RM (5.11%). However, when EP rates were calculated not by women but by overall pregnancies, no differences could be found between RM and control women. In control women, the absence of a miscarriage in the reproductive history was associated with a lower rate of EP. Women with RM, particularly primary RM, are at increased risk of EP. This increased risk seems to be dependent on the high number of pregnancies occurring in women with RM rather than to specific characteristics of these women. © 2018 Japan Society of Obstetrics and Gynecology.

Instinct & Imagination: Froebel's Principal of Self-Activity in Turn-of-the-Century Song Books.

ERIC Educational Resources Information Center

Alper, Clifford D.

1985-01-01

Children's natural endeavors that enable them to attain self-realization and fulfillment were given the name "self-activity" by the German philosopher Friedrich Froebel. Discussed are components traceable to the self-activity principle that appear in early childhood song materials published around the turn of the century. (RM)

76 FR 24495 - Reprocessing of Reusable Medical Devices; Public Workshop

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

... workshop will be held in the Great Room at the FDA White Oak Conference Center, Bldg. 31, Rm. 1503, 10903... requests to make oral presentations, as well as presentation materials, must be sent to the contact person... sterilization process, potentially resulting in HAIs or other adverse patient outcomes. FDA receives reports of...

75 FR 82382 - Electronic Tariff Filings; Notice of Technical Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RM01-5-000] Electronic... electronic filing of tariff and tariff related materials pursuant to Order No. 714.\\1\\ The technical... implementation of eTariff. \\1\\ Electronic Tariff Filings, Order No. 714, 73 FR 57,515 (Oct. 3, 2008), 124 FERC...

A platform for studying the Rayleigh-Taylor and Richtmyer-Meshkov instabilities in a planar geometry at high energy density at the National Ignition Facility

NASA Astrophysics Data System (ADS)

Nagel, S. R.; Raman, K. S.; Huntington, C. M.; MacLaren, S. A.; Wang, P.; Barrios, M. A.; Baumann, T.; Bender, J. D.; Benedetti, L. R.; Doane, D. M.; Felker, S.; Fitzsimmons, P.; Flippo, K. A.; Holder, J. P.; Kaczala, D. N.; Perry, T. S.; Seugling, R. M.; Savage, L.; Zhou, Y.

2017-07-01

A new experimental platform has been developed at the National Ignition Facility (NIF) for studying the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities in a planar geometry at high-energy-densities. The platform uses 60 beams of the NIF laser to drive an initially solid shock tube containing a pre-machined interface between dense and light materials. The strong shock turns the initially solid target into a plasma and the material boundary into a fluid interface with the imprinted initial condition. The interface evolves by action of the RT and RM instabilities, and the growth is imaged with backlit x-ray radiography. We present our first data involving sinusoidal interface perturbations driven from the heavy side to the light side. Late-time radiographic images show the initial conditions reaching the deeply nonlinear regime, and an evolution of fine structure consistent with a transition to turbulence. We show preliminary comparisons with post-shot numerical simulations and discuss the implications for future campaigns.

Factors and values of willingness to pay for improved construction waste management--a perspective of Malaysian contractors.

PubMed

Begum, Rawshan Ara; Siwar, Chamhuri; Pereira, Joy Jacqueline; Jaafar, Abdul Hamid

2007-01-01

Malaysia is facing an increase in the generation of waste and of accompanying problems with the disposal of this waste. In the last two decades, extensive building and infrastructure development projects have led to an increase in the generation of construction waste material. The construction industry has a substantial impact on the environment, and its environmental effects are in direct relation to the quality and quantity of the waste it generates. This paper discusses general characteristics of the construction contractors, the contractors' willingness to pay (WTP) for improved construction waste management, determining factors which affect the amount of their willingness to pay, and suggestions and policy implications in the perspective of construction waste management in Malaysia. The data in this study is based on contractors registered with the construction industry development board (CIDB) of Malaysia. Employing the open ended contingent valuation method, the study assessed the contractors' average maximum WTP for improved construction waste management to be RM69.88 (1US$=3.6 RM) per tonne of waste. The result shows that the average maximum WTP is higher for large contractors than for medium and small contractors. The highest average maximum WTP value is RM88.00 for Group A (large contractors) RM78.25 for Group B (medium-size contractors) and RM55.80 for Group C (small contractors). One of the contributions of this study is to highlight the difference of CIDB registration grade in the WTP for improved construction waste management. It is found that contractors' WTP for improved waste collection and disposal services increases with the increase in contractors' current paid up capital. The identified factors and determinants of the WTP will assist the formulation of appropriate policies in addressing the construction waste problem in Malaysia and indirectly improve the quality of construction in the country.

The influence of isometric preload on power expressed during bench press in strength-trained men.

PubMed

Bartolomei, Sandro; Fukuda, David H; Hoffman, Jay R; Stout, Jeffrey R; Merni, Franco

2017-03-01

The purpose of this study was to compare the power expressed during the bench press exercise in resistance-trained men following different pre-activation conditions. Twenty-two trained men (age 24.1 ± 1.7 years, height 178.6 ± 6.1 cm, body mass 81.1 ± 10.6 kg) completed a maximal effort bench press (1-RM) test (100.0 kg ± 8.1 kg). In a subsequent assessment, each participant performed concentric bench press movements with loads of 20%, 30%, 40% and 50% of their 1-RM preceded by either a concentric contraction (CC), a low isometric preload (LIP; 70% 1-RM) or a high isometric preload (HIP; 100% 1-RM) conditions. All movements were performed in a Smith machine with a settable quick-release device. Participants performed all three conditions in randomized fashion. Results indicated that power outputs during the bench press exercise following HIP were significantly (p < 0.05) greater than CC at 20% 1-RM (+9%), 30% 1-RM (+16%) and 40% 1-RM (+14%), and LIP at 20% 1-RM (+4%), 30% 1-RM (+20%) and 40% 1-RM (+15%). No differences were found between conditions at 50% 1-RM. Area under the force-power curve with HIP was greater (p < 0.05) than with CC and LIP. In conclusion, results of this study indicate that the use of a HIP (100% 1-RM) in trained participants results in significantly greater power output during the concentric phase of a multi-joint exercise when compared to standard concentric movement.

Structural and biochemical insights into the substrate-binding mechanism of a novel glycoside hydrolase family 134 β-mannanase.

PubMed

You, Xin; Qin, Zhen; Li, Yan-Xiao; Yan, Qiao-Juan; Li, Bin; Jiang, Zheng-Qiang

2018-06-01

Mannan is one of the major constituent groups of hemicellulose, which is a renewable resource from higher plants. β-Mannanases are enzymes capable of degrading lignocellulosic biomass. Here, an endo-β-mannanase from Rhizopus microsporus (RmMan134A) was cloned and expressed. The recombinant RmMan134A showed maximal activity at pH 5.0 and 50 °C, and exhibited high specific activity towards locust bean gum (2337 U/mg). To gain insight into the substrate-binding mechanism of RmMan134A, four complex structures (RmMan134A-M3, RmMan134A-M4, RmMan134A-M5 and RmMan134A-M6) were further solved. These structures showed that there were at least seven subsites (-3 to +4) in the catalytic groove of RmMan134A. Mannose in the -1 subsite hydrogen bonded with His113 and Tyr131, revealing a unique conformation. Lys48 and Val159 formed steric hindrance, which impedes to bond with galactose branches. In addition, the various binding modes of RmMan134A-M5 indicated that subsites -2 to +2 are indispensable during the hydrolytic process. The structure of RmMan134A-M4 showed that mannotetrose only binds at subsites +1 to +4, and RmMan134A could therefore not hydrolyze mannan oligosaccharides with degree of polymerization ≤4. Through rational design, the specific activity and optimal conditions of RmMan134A were significantly improved. The purpose of this paper is to investigate the structure and function of fungal GH family 134 β-1,4-mannanases, and substrate-binding mechanism of GH family 134 members. Copyright © 2018 Elsevier B.V. All rights reserved.

Absolute Calibration of Si iRMs used for Measurements of Si Paleo-nutrient proxies

NASA Astrophysics Data System (ADS)

Vocke, R. D., Jr.; Rabb, S. A.

2016-12-01

Silicon isotope variations (reported as δ30Si and δ29Si, relative to NBS28) in silicic acid dissolved in ocean waters, in biogenic silica and in diatoms are extremely informative paleo-nutrient proxies. The resolution and comparability of such measurements depend on the quality of the isotopic Reference Materials (iRMs) defining the delta scale. We report new absolute Si isotopic measurements on the iRMs NBS28 (RM 8546 - Silica Sand), Diatomite, and Big Batch using the Avogadro measurement approach and comparing them with prior assessments of these iRMs. The Avogadro Si measurement technique was developed by the German Physikalish-Technische Bundesanstalt (PTB) to provide a precise and highly accurate method to measure absolute isotopic ratios in highly enriched 28Si (99.996%) material. These measurements are part of an international effort to redefine the kg and mole based on the Planck constant h and the Avogadro constant NA, respectively (Vocke et al., 2014 Metrologia 51, 361, Azuma et al., 2015 Metrologia 52 360). This approach produces absolute Si isotope ratio data with lower levels of uncertainty when compared to the traditional "Atomic Weights" method of absolute isotope ratio measurement calibration. This is illustrated in Fig. 1 where absolute Si isotopic measurements on SRM 990, separated by 40+ years of advances in instrumentation, are compared. The availability of this new technique does not say that absolute Si isotopic ratios are or ever will be better for normal Si isotopic measurements when seeking isotopic variations in nature, because they are not. However, by determining the absolute isotopic ratios of all the Si iRM scale artifacts, such iRMs become traceable to the metric system (SI); thereby automatically conferring on all the artifact-based δ30Si and δ29Si measurements traceability to the base SI unit, the mole. Such traceability should help reduce the potential of bias between different iRMs and facilitate the replacement of delta-scale artefacts when they run out. Fig. 1 Comparison of absolute isotopic measurements of SRM 990 using two radically different approaches to absolute calibration and mass bias corrections.

Development and validation of a turbulent-mix model for variable-density and compressible flows.

PubMed

Banerjee, Arindam; Gore, Robert A; Andrews, Malcolm J

2010-10-01

The modeling of buoyancy driven turbulent flows is considered in conjunction with an advanced statistical turbulence model referred to as the BHR (Besnard-Harlow-Rauenzahn) k-S-a model. The BHR k-S-a model is focused on variable-density and compressible flows such as Rayleigh-Taylor (RT), Richtmyer-Meshkov (RM), and Kelvin-Helmholtz (KH) driven mixing. The BHR k-S-a turbulence mix model has been implemented in the RAGE hydro-code, and model constants are evaluated based on analytical self-similar solutions of the model equations. The results are then compared with a large test database available from experiments and direct numerical simulations (DNS) of RT, RM, and KH driven mixing. Furthermore, we describe research to understand how the BHR k-S-a turbulence model operates over a range of moderate to high Reynolds number buoyancy driven flows, with a goal of placing the modeling of buoyancy driven turbulent flows at the same level of development as that of single phase shear flows.

A New Soluble Gelatin Sponge for Transcatheter Hepatic Arterial Embolization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takasaka, Isao; Kawai, Nobuyuki; Sato, Morio, E-mail: morisato@mail.wakayama-med.ac.jp

2010-12-15

To prepare a soluble gelatin sponge (GS) and to explore the GS particles (GSPs) that inhibit development of collateral pathways when transcatheter hepatic arterial embolization is performed. The approval of the Institutional Committee on Research Animal Care of our institution was obtained. By means of 50 and 100 kDa of regenerative medicine-gelatin (RM-G), RM-G sponges were prepared by freeze-drying and heating to temperatures of 110-150{sup o}C for cross-linkage. The soluble times of RM-GSPs were measured in vitro. Eight swine for transcatheter hepatic arterial embolization were assigned into two groups: six received 135{sup o}C/50RM-GSPs, 125{sup o}C/100RM-GSPs, and 138{sup o}C/50RM-GSPs, with solublemore » time of 48 h or more in vitro; two swine received Gelpart GSPs (G-GSPs) with insoluble time of 14 days as a control. Transarterial chemoembolization was performed on two branches of the hepatic artery per swine. RM-GSPs heated at temperatures of 110-138{sup o}C were soluble. Mean soluble times of the RM-GSPs increased with higher temperature. Hepatic branches embolized with G-GSP remained occluded after 6 days, and development of collateral pathways was observed after 3 days. Hepatic branches embolized with 135{sup o}C/50RM-GSP and 125{sup o}C/100RM-GSP remained occluded for 4 h, and recanalization was observed after 1 day. Hepatic branches embolized with 138{sup o}C/50RM-GS remained occluded for 1 day, and recanalization was observed after 2 days with no development of collateral pathways. In RM-GSs with various soluble times that were prepared by modulating the heating temperature, 138{sup o}C/50RM-GSP was the soluble GSP with the longest occlusion time without inducing development of collateral pathways.« less

Optically dark excitonic states mediated exciton and biexciton valley dynamics in monolayer WSe₂.

PubMed

Zhang, Minghua; Fu, Jiyong; Dias, A C; Qu, Fanyao

2018-05-18

We present a theory to address the photoluminescence (PL) intensity and valley polarization (VP) dynamics in monolayer WSe$_2$, under the impact of excitonic dark states of both excitons and biexcitons. We find that the PL intensity of all excitonic channels including intravalley exciton (X$_{\\rm b}$), intravalley biexciton (XX$_{\\rm k,k}$) and intervalley biexciton (XX$_{\\rm k,k^\\prime}$) in particular for the {XX$_{\\rm k,k}$} PL is enhanced by laser excitation fluence. In addition, our results indicate the anomalous temperature dependence of PL, i.e., increasing with temperature, as a result of favored phonon assisted dark-to-bright scatterings at high temperatures. Moreover, we observe that the PL is almost immune to intervalley scatterings, which trigger the exchange of excitonic states between the two valleys. As far as the valley polarization is concerned, we find that the VP of X$_{\\rm b}$ shrinks as temperature increases, exhibiting opposite temperature response to PL, while the intravalley XX$_{\\rm k,k}$ VP is found almost independent of temperature. In contrast to both X$_{\\rm b}$ and XX$_{\\rm k,k}$, the intervalley XX$_{\\rm k,k^\\prime}$ VP identically vanishes, because of equal populations of excitons in the $K$ and $K^\\prime$ valleys bounded to form intervalley biexcitons. Notably, it is found that the X$_{\\rm b}$ VP much more strongly depends on bright-dark scattering than that of {XX$_{\\rm k,k}$}, making dark state act as a robust reservoir for valley polarization against intervalley scatterings for X$_{\\rm b}$ at strong bright-dark scatterings, but not for XX$_{\\rm k,k}$. Dark excitonic states enabled enhancement of VP benefits quantum technology for information processing based on the valley degree of freedom in valleytronic devices. Furthermore, the VP has strong dependence on intervalley scattering but maintains essentially constant with excitation fluence. Finally, the time evolution of PL and VP, depending on temperature and excitation fluence, is discussed. © 2018 IOP Publishing Ltd.

Performance of three reflectance calibration methods for airborne hyperspectral spectrometer data.

PubMed

Miura, Tomoaki; Huete, Alfredo R

2009-01-01

In this study, the performances and accuracies of three methods for converting airborne hyperspectral spectrometer data to reflectance factors were characterized and compared. The "reflectance mode (RM)" method, which calibrates a spectrometer against a white reference panel prior to mounting on an aircraft, resulted in spectral reflectance retrievals that were biased and distorted. The magnitudes of these bias errors and distortions varied significantly, depending on time of day and length of the flight campaign. The "linear-interpolation (LI)" method, which converts airborne spectrometer data by taking a ratio of linearly-interpolated reference values from the preflight and post-flight reference panel readings, resulted in precise, but inaccurate reflectance retrievals. These reflectance spectra were not distorted, but were subject to bias errors of varying magnitudes dependent on the flight duration length. The "continuous panel (CP)" method uses a multi-band radiometer to obtain continuous measurements over a reference panel throughout the flight campaign, in order to adjust the magnitudes of the linear-interpolated reference values from the preflight and post-flight reference panel readings. Airborne hyperspectral reflectance retrievals obtained using this method were found to be the most accurate and reliable reflectance calibration method. The performances of the CP method in retrieving accurate reflectance factors were consistent throughout time of day and for various flight durations. Based on the dataset analyzed in this study, the uncertainty of the CP method has been estimated to be 0.0025 ± 0.0005 reflectance units for the wavelength regions not affected by atmospheric absorptions. The RM method can produce reasonable results only for a very short-term flight (e.g., < 15 minutes) conducted around a local solar noon. The flight duration should be kept shorter than 30 minutes for the LI method to produce results with reasonable accuracies. An important advantage of the CP method is that the method can be used for long-duration flight campaigns (e.g., 1-2 hours). Although this study focused on reflectance calibration of airborne spectrometer data, the methods evaluated in this study and the results obtained are directly applicable to ground spectrometer measurements.

Developing the science and technology for the Material Plasma Exposure eXperiment

DOE PAGES

Rapp, J.; Biewer, T. M.; Bigelow, T. S.; ...

2017-07-27

Linear plasma generators are cost effective facilities to simulate divertor plasma conditions of present and future fusion reactors. They are used to address important R&D gaps in the science of plasma material interactions and towards viable plasma facing components for fusion reactors. Next generation plasma generators have to be able to access the plasma conditions expected on the divertor targets in ITER and future devices. The steady-state linear plasma device MPEX will address this regime with electron temperatures of 1–10 eV and electron densities ofmore » $$10^{21}{\\text{}}\\!-\\!10^{20}$$ $${\\rm m}^{-3}$$. The resulting heat fluxes are about 10 MW $${\\rm m}^{-2}$$ . MPEX is designed to deliver those plasma conditions with a novel Radio Frequency plasma source able to produce high density plasmas and heat electron and ions separately with electron Bernstein wave (EBW) heating and ion cyclotron resonance heating with a total installed power of 800 kW. The linear device Proto-MPEX, forerunner of MPEX consisting of 12 water-cooled copper coils, has been operational since May 2014. Its helicon antenna (100 kW, 13.56 MHz) and EC heating systems (200 kW, 28 GHz) have been commissioned and 14 MW $${\\rm m}^{-2}$$ was delivered on target. Furthermore, electron temperatures of about 20 eV have been achieved in combined helicon and ECH heating schemes at low electron densities. Overdense heating with EBW was achieved at low heating powers. The operational space of the density production by the helicon antenna was pushed up to $$1.1 \\times 10^{20}$$ $${\\rm m}^{-3}$$ at high magnetic fields of 1.0 T at the target. Finally, the experimental results from Proto-MPEX will be used for code validation to enable predictions of the source and heating performance for MPEX. MPEX, in its last phase, will be capable to expose neutron-irradiated samples. In this concept, targets will be irradiated in ORNL's High Flux Isotope Reactor and then subsequently exposed to fusion reactor relevant plasmas in MPEX.« less

Developing the science and technology for the Material Plasma Exposure eXperiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rapp, J.; Biewer, T. M.; Bigelow, T. S.

Linear plasma generators are cost effective facilities to simulate divertor plasma conditions of present and future fusion reactors. They are used to address important R&D gaps in the science of plasma material interactions and towards viable plasma facing components for fusion reactors. Next generation plasma generators have to be able to access the plasma conditions expected on the divertor targets in ITER and future devices. The steady-state linear plasma device MPEX will address this regime with electron temperatures of 1–10 eV and electron densities ofmore » $$10^{21}{\\text{}}\\!-\\!10^{20}$$ $${\\rm m}^{-3}$$. The resulting heat fluxes are about 10 MW $${\\rm m}^{-2}$$ . MPEX is designed to deliver those plasma conditions with a novel Radio Frequency plasma source able to produce high density plasmas and heat electron and ions separately with electron Bernstein wave (EBW) heating and ion cyclotron resonance heating with a total installed power of 800 kW. The linear device Proto-MPEX, forerunner of MPEX consisting of 12 water-cooled copper coils, has been operational since May 2014. Its helicon antenna (100 kW, 13.56 MHz) and EC heating systems (200 kW, 28 GHz) have been commissioned and 14 MW $${\\rm m}^{-2}$$ was delivered on target. Furthermore, electron temperatures of about 20 eV have been achieved in combined helicon and ECH heating schemes at low electron densities. Overdense heating with EBW was achieved at low heating powers. The operational space of the density production by the helicon antenna was pushed up to $$1.1 \\times 10^{20}$$ $${\\rm m}^{-3}$$ at high magnetic fields of 1.0 T at the target. Finally, the experimental results from Proto-MPEX will be used for code validation to enable predictions of the source and heating performance for MPEX. MPEX, in its last phase, will be capable to expose neutron-irradiated samples. In this concept, targets will be irradiated in ORNL's High Flux Isotope Reactor and then subsequently exposed to fusion reactor relevant plasmas in MPEX.« less

Characterization and Potential Environmental Risks of Leachate from Shredded Rubber Mulches

PubMed Central

Kanematsu, Masakazu; Hayashi, Ai; Denison, Michael S.; Young, Thomas M.

2009-01-01

In order to determine whether shredded rubber mulches (RM) posed water quality risks when used in stormwater best management practices (BMPs) such as bioretention basins, batch leaching tests were conducted to identify and quantify constituents in leachates from RM such as metal ions, nutrients, total organic carbon (TOC), and aryl hydrocarbon receptor (AhR) activity (determined by the chemically activated luciferase gene expression (CALUX) bioassay) at varied temperature and initial pH values. The results indicate that aqueous extracts of RM contain high concentrations of zinc (Zn) compared with wood mulches (WM), and its concentration increased at lower pH and higher temperature. Although methanol extracts of RM displayed high AhR activity, none of the aqueous extracts of RM had significant activity. Hence, while unknown constituents that have significant AhR activity are present in RM, they appear to be not measurably extracted by water under environmental conditions relevant for stormwater (5 < pH < 9, 10 < T < 40°C). Our results suggests that organic constituents in water extracts of RM which have AhR activity may not be of significant concern while leaching of Zn from RM appears to be a potentially larger water quality issue for RM. PMID:19450864

The Effects of Ultrasound on Biological Systems: Site

NASA Astrophysics Data System (ADS)

El-Karmi, Anan M.

Earlier studies (Dinno et al., Ultrasound Med. Biol. 15:461 -470; 1989) demonstrated that ultrasound at therapeutic intensities causes large increases in total conductance (G_{rm t}) of frog skin. These changes were attributed to non-thermal mechanisms, primarily, cavitation. In this study, the site(s) and mechanism(s) of action of ultrasound for the increase in G_{rm t} were examined. The reversible changes in G_{rm t } and sodium current were monitored in real time as a function of ultrasound exposure. Amiloride, a sodium channel blocker, was used to differentiate between cellular (G_{rm c}) and paracellular (G_{rm s}) pathways in the presence and absence of ultrasound. No significant changes were detected in G_ {rm c}. However, changes in G _{rm s} were significant. These results demonstrate that most of the increase in G _{rm t} due to ultrasound is taking place in the paracellular pathways. Sodium channels were not significantly affected by ultrasound. Thus, the changes in G_{rm c} are not specific. The effects of ultrasound were examined in the presence of radical scavengers and antioxidants. The increase in G_{rm t} due to ultrasound was significantly minimized in the presence of cystamine, cysteamine, and sodium ascorbate. This demonstrates that free radicals and other reactive species generated by cavitation are causing the increase in G_ {rm t}, possibly by acting from inside the cells. Radical scavengers and antioxidants are providing protection from oxidative damage but are not involved in the recovery of G_{ rm t} towards steady state values after sonication. The role of Ca^{2+} in the effects of ultrasound was examined since many of the cellular reactions involved in tissue recovery are dependent on the intracellular availability of free Ca^{2+}. The percentage increase in G_{rm t} in the presence of Ca^{2+} was larger than in its absence (140% vs. 27%). The time constant for G_{rm t} to return to steady state was longer in calcium-free solutions (122 vs. 18 minutes). This demonstrates that the biological effects of ultrasound are influenced by Ca^ {2+}. The larger increases in G _{rm t} and the time constants confirm other studies addressing the role of Ca ^{2+} in potentiating lipid peroxidation by free radicals, and the role of calcium ions in the formation of tight junctions.

Comparative cost-effectiveness of HPV vaccines in the prevention of cervical cancer in Malaysia.

PubMed

Ezat, Sharifa W P; Aljunid, Syed

2010-01-01

Cervical cancer (CC) had the second highest incidence of female cancers in Malaysia in 2003-2006. Prevention is possible by both Pap smear screening and HPV vaccination with either the bivalent vaccine (BV) or the quadrivalent vaccine (QV). In the present study, cost effectiveness options were compared for three programs i.e. screening via Pap smear; modeling of HPV vaccination (QV and BV) and combined strategy (screening plus vaccination). A scenario based sensitivity analysis was conducted using screening population coverages (40-80%) and costs of vaccines (RM 100-200/dose) were calculated. This was an economic burden, cross sectional study in 2006-2009 of respondents interviewed from six public Gynecology-Oncology hospitals. Methods included expert panel discussions to estimate treatment costs of CC, genital warts and vulva/vagina cancers by severity and direct interviews with respondents using costing and SF-36 quality of life questionnaires. A total of 502 cervical cancer patients participated with a mean age at 53.3±11.2 years and a mean marriage length of 27.7±12.1 years, Malays accounting for 44.2%. Cost/quality adjusted life year (QALY) for Pap smear in the base case was RM 1,215 and RM 1,100 at increased screening coverage. With QV only, in base case it was RM 15,662 and RM 24,203 when the vaccination price was increased. With BV only, the respective figures were RM 1,359,057 and RM 2,530,018. For QV combined strategy cost/QALY in the base case it was RM 4,937, reducing to RM 3,395 in the best case and rising to RM 7,992 in the worst case scenario. With the BV combined strategy, these three cost/QALYs were RM 6,624, RM 4,033 and RM 10,543. Incremental cost-effectiveness ratio (ICER) showed that screening at 70% coverage or higher was highly cost effective at RM 946.74 per QALYs saved but this was preceded by best case combined strategy with QV at RM 515.29 per QALYs saved. QV is more cost effective than BV. The QV combined strategy had a higher CE than any method including Pap smear screening at high population coverage.

Tensile properties and impact toughness of S30408 stainless steel and its welded joints at cryogenic temperatures

NASA Astrophysics Data System (ADS)

Ding, Huiming; Wu, Yingzhe; Lu, Qunjie; Xu, Ping; Zheng, Jinyang; Wei, Lijun

2018-06-01

Designing a cryogenic pressure vessel based on the mechanical properties of the austenitic stainless steel (ASS) at its cryogenic operating temperature fully utilizes the potential of the material at low temperatures, resulting in lightweight and compact products. A series of tensile tests and impact tests were carried out in a wide range of 77-293 K, to investigate the mechanical properties of S30408 base metal (BM) and welded joints (WJ) at cryogenic temperatures. As the temperature decreases, yield stress (Rp0.2) and ultimate tensile stress (Rm) increase significantly thanks to the low-temperature strengthening effects. To estimate strengths at cryogenic temperatures, quadratic polynomial model was used to accurately predict the variations of Rp0.2 and Rm from 77 K to 293 K. As an important phase in the WJ, ferrite presents a radial pattern and an inhomogeneity in the WJ's cross-section. Due to the formation of ferrite in the WJ, the WJ has higher Rp0.2 and lower Rm , Charpy absorbed energy and lateral expansion compared with the BM. Strain-induced martensite transformation is an important role influencing the deformation of ASS at low temperatures. In this study, less martensite amount was measured in the weldment zone with higher Nickel equivalents which stabilize the austenite phase at cryogenic temperatures. Additionally, due to higher ferrite content and more precipitates forming, the SAW joints has lower Rm and impact toughness than PAW + GTAW joints. To ensure the structural integrity and safety, the PAW + GTAW method should be chosen and ferrite content be controlled.

Guidelines for the Selection of Chemical Protective Clothing. Volume 2. Technical and Reference Manual.

DTIC Science & Technology

1987-02-01

Handler’s Suit for Protection from Chlorine Trifluoride and Elemental Fluorine Technical Report AFRPL-TR-71-44 (August 1971) NTIS AD731556 199 Masterman’s...Protective Clothing for Chlorine , Edition 1 Chlorine Institute Pamphlet 65, The Chlorine Institute, Inc. New York, New York, (June 1978) 15 Anon...Chemical Company Selection of Gloves for Use With Chlorinated Solvents Chlorinated Solvents Information Midland, Michigan 48640 101 Duffy, R.M., A.R.Beer

MDA-based EHR application security services.

PubMed

Blobel, Bernd; Pharow, Peter

2004-01-01

Component-oriented, distributed, virtual EHR systems have to meet enhanced security and privacy requirements. In the context of advanced architectural paradigms such as component-orientation, model-driven, and knowledge-based, standardised security services needed have to be specified and implemented in an integrated way following the same paradigm. This concerns the deployment of formal models, meta-languages, reference models such as the ISO RM-ODP, and development as well as implementation tools. International projects' results presented proceed on that streamline.

Architectural assessment of rhesus macaque pelvic floor muscles: comparison for use as a human model.

PubMed

Stewart, Amanda M; Cook, Mark S; Esparza, Mary C; Slayden, Ov D; Alperin, Marianna

2017-10-01

Animal models are essential to further our understanding of the independent and combined function of human pelvic floor muscles (PFMs), as direct studies in women are limited. To assure suitability of the rhesus macaque (RM), we compared RM and human PFM architecture, the strongest predictor of muscle function. We hypothesized that relative to other models, RM best resembles human PFM. Major architectural parameters of cadaveric human coccygeus, iliococcygeus, and pubovisceralis (pubococcygeus + puborectalis) and corresponding RM coccygeus, iliocaudalis, and pubovisceralis (pubovaginalis + pubocaudalis) were compared using 1- and 2-way analysis of variance (ANOVA) with post hoc testing. Architectural difference index (ADI), a combined measure of functionally relevant structural parameters predictive of length-tension, force-generation, and excursional muscle properties was used to compare PFMs across RM, rabbit, rat, and mouse. RM and human PFMs were similar with respect to architecture. However, the magnitude of similarity varied between individual muscles, with the architecture of the most distinct RM PFM, iliocaudalis, being well suited for quadrupedal locomotion. Except for the pubovaginalis, RM PFMs inserted onto caudal vertebrae, analogous to all tailed animals. Comparison of the PFM complex architecture across species revealed the lowest, thus closest to human, ADI for RM (1.9), followed by rat (2.0), mouse (2.6), and rabbit (4.7). Overall, RM provides the closest architectural representation of human PFM complex among species examined; however, differences between individual PFMs should be taken into consideration. As RM is closely followed by rat with respect to PFM similarity with humans, this less-sentient and substantially cheaper model is a good alternative for PFM studies.

Two-Dimensional (2-D) Acoustic Fish Tracking at River Mile 85, Sacramento River, California

DTIC Science & Technology

2013-06-01

on fish become known (USACE 2004). Levee repair and constructed habitat features included (1) protection of the toe and upper slopes of the bank...be recovered rather than being lost due to sediment dunes , large woody material floating downstream, and vandalism. The RM 85 site was a relatively...into the river channel. The addition of this material narrowed the channel and created a scour feature along the toe of the repair site. VPS array

Rehabilitation Medicine Educational Experiences: A Retrospective Study of Exposure to RM.

ERIC Educational Resources Information Center

Dobmeyer, Thomas W.

1979-01-01

A study was conducted to determine: the effect of rehabilitation medicine (RM) educational experiences during medical school on physicians' awareness of RM; attitude toward RM; the management of long-term care; and the tendency to seek expert consultation and patient referral when necessary. (Author/MH)

77 FR 2242 - Radio Broadcasting Services; Ehrenberg, First Mesa, Kachina Village, Wickenburg, and Williams, AZ...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [MB Docket No. 08-85; RM-11427, RM-11517, RM-11518, RM-11519; DA 11- 2059] Radio Broadcasting Services; Ehrenberg, First Mesa, Kachina Village, Wickenburg, and Williams, AZ, and Needles, CA AGENCY: Federal Communications Commission. ACTION: Proposed...

Analysis and application of a velocity command motor as a reaction mass actuator

NASA Technical Reports Server (NTRS)

Sulla, Jeffrey L.; Juang, Jer-Nan; Horta, Lucas G.

1990-01-01

A commercially available linear stepper motor is applied as a reaction mass (RM) actuator. With the actuator operating in the (RM) relative-velocity command mode, open-loop and closed-loop testing is performed to determine operational limits. With the actuator mounted on a simple beam structure, root strain, RM acceleration, or beam acceleration is used in the feedback loop to augment the structural damping. The RM relative position is also used as feedback to ensure that the RM remains centered.

Dielectric Properties of Sol-Gel Derived Barium Strontium Titanate and Microwave Sintering of Ceramics

NASA Astrophysics Data System (ADS)

Selmi, Fathi A.

This thesis consists of two areas of research: (1) sol-gel processing of Ba_{rm 1-x}Sr_{rm x} TiO_3 ceramics and their dielectric properties measurement; and (2) microwave versus conventional sintering of ceramics such as Al_2 O_3, Ba_{ rm 1-x}Sr_{rm x}TiO_3, Sb-doped SnO _2 and YBa_2Cu _3O_7. Sol-gel powders of BaTiO_3, SrTiO_3, and their solid solutions were synthesized by the hydrolysis of titanium isopropoxide and Ba and Sr methoxyethoxides. The loss tangent and dielectric constant of both sol-gel and conventionally prepared and sintered Ba_{rm 1-x}Sr _{rm x}TiO _3 ceramics were investigated at high frequencies. The sol-gel prepared ceramics showed higher dielectric constant and lower loss compared to those prepared conventionally. Ba _{rm 1-x}Sr _{rm x}TiO_3 ceramics were tunable with applied bias, indicating the potential use of this material for phase shifter applications. Porous Ba_{0.65}Sr _{0.35}TiO_3 was also investigated to lower the dielectric constant. Microwave sintering of alpha -Al_2O_3 and SrTiO_3 was investigated using an ordinary kitchen microwave oven (2.45 GHz; 600 Watts). The use of microwaves with good insulation of alpha -Al_2O_3 and SrTiO_3 samples resulted in their rapid sintering with good final densities of 96 and 98% of the theoretical density, respectively. A comparison of grain size for conventionally and microwave sintered SrTiO_3 samples did not show a noticeable difference. However, the grain size of microwave sintered alpha-Al_2O _3 was found to be larger than that of conventionally sintered sample. These results show that rapid sintering of ceramics can be achieved by using microwave radiation. The sintering behavior of coprecipitated Sb-doped SnO_2 was investigated using microwave power absorption. With microwave power, samples were sintered at 1450^circC for 20 minutes and showed a density as high as 99.9% of theoretical. However, samples fired in a conventional electric furnace at the same temperature for 4 hours showed only 60% of theoretical density. Microwave sintering also led to improvement in terms of uniform structure and electrical properties. Ba_{0.65}Sr _{0.35}TiO_3 was sintered using the microwave power at 1300 ^circC for 10 minutes. A density of 99% was achieved with small and uniform grain size. Superconducting powders have been successfully prepared by the sol-gel process and sintered and annealed using microwave power. Sintering and densification was achieved in a shorter time with microwave heating than with conventional heating and microwave heating appears to result in refined microstructure.

The effects of respiratory-muscle training on exercise in older women.

PubMed

Watsford, Mark; Murphy, Arona

2008-07-01

This research examined the effects of respiratory-muscle (RM) training on RM function and exercise performance in older women. Twenty-six women (60-69 yr of age) were assessed for spirometry, RM strength (maximal inspiratory and expiratory pressure), inspiratory-muscle endurance, and walking performance to a perceived exertion rating of "hard." They were randomly allocated to a threshold RM training group (RMT) or a nonexercising control group (CON) for 8 wk.After training, the 22% (inspiratory) and 30% (expiratory) improvements in RM strength in the RMT group were significantly higher than in the CON group (p < .05). The RMT group also displayed several significant performance improvements, including improved within-group treadmill performance time (12%) and reductions in submaximal heart rate (5%), percentage of maximum voluntary ventilation (16%), and perceived exertion for breathing (8%). RM training appears to improve RM function in older women. Furthermore, these improvements appear to be related to improved submaximal exercise performance.

UFOs as an Exercise in Discretionary Thinking in the Secondary School Classroom.

ERIC Educational Resources Information Center

Davis, Robert S., Jr.

1984-01-01

From the late 1940s through the 1970s the belief that we were being visited by intelligent guests from other worlds swept the United States and the world. Discusses how materials generated by the unidentified flying objects controversy can be used to encourage secondary students to examine a popular topic. (RM)

Pigment analysis by Raman microscopy and portable X-ray fluorescence (pXRF) of thirteenth to fourteenth century illuminations and cuttings from Bologna

PubMed Central

Clark, Robin J. H.; Jones, Richard; Gibbs, Robert

2016-01-01

Non-destructive pigment analysis by Raman microscopy (RM) and portable X-ray fluorescence (pXRF) has been carried out on some Bolognese illuminations and cuttings chosen to represent the beginnings, evolution and height of Bolognese illuminated manuscript production. Dating to the thirteenth and fourteenth centuries and held in a private collection, the study provides evidence for the pigments generally used in this period. The results, which are compared with those obtained for other north Italian artwork, show the developments in usage of artistic materials and technique. Also addressed in this study is an examination of the respective roles of RM and pXRF analysis in this area of technical art history. This article is part of the themed issue ‘Raman spectroscopy in art and archaeology’. PMID:27799427

The Nordic contribution to the English language twin literature.

PubMed

Schwartz, R M; Keith, L G; Keith, D M

1986-01-01

This project was inspired by the extensive contribution of Nordic researchers to the English language twin literature. The purpose of the study was to compile a source bibliography of twin literature written at Nordic institutions. The bibliography compiled as a supplement for this paper provides as complete a survey as is possible to obtain in the United States. Our search began with a Medline Computer data base. To make our survey more complete, we cross-referenced and added to this using the Index Medicus, the National Institute of Mental Health Bibliography, Excerpta Medica, specific article references, references provided by Nordic university libraries and Gedda's Estudio dei Gemelli. The full bibliography of 313 references is available at no cost from the Center for the study of multiple Birth, Rm. 476, 333 E. Superior, Chicago, Ill. 60611, U.S.A.

Stabilization of Cd-, Pb-, Cu- and Zn-contaminated calcareous agricultural soil using red mud: a field experiment.

PubMed

Wang, Yangyang; Li, Fangfang; Song, Jian; Xiao, Ruiyang; Luo, Lin; Yang, Zhihui; Chai, Liyuan

2018-04-12

Red mud (RM) was used to remediate heavy metal-contaminated soils. Experiments with two different dosages of RM added to soils were carried out in this study. It was found that soil pH increased 0.3 and 0.5 unit with the dosage of 3 and 5% (wt%), respectively. At the dosage of 5%, the highest stabilization efficiencies for Cd, Pb, Cu and Zn reached 67.95, 64.21, 43.73 and 63.73%, respectively. The addition of RM obviously transferred Cd from the exchangeable fraction to the residual fraction. Meanwhile, in comparison with the control (no RM added), it reduced 24.38, 49.20, 19.42 and 8.89% of Cd, Pb, Cu and Zn in wheat grains at the RM addition dosage of 5%, respectively. At the same time, the yield of wheat grains increased 17.81 and 24.66% at the RM addition dosage of 3 and 5%, respectively. Finally, the addition of RM did not change the soil bacterial community. These results indicate that RM has a great potential in stabilizing heavy metals in calcareous agricultural soils.

Using Bar Velocity to Predict the Maximum Dynamic Strength in the Half-Squat Exercise.

PubMed

Loturco, Irineu; Pereira, Lucas A; Cal Abad, Cesar C; Gil, Saulo; Kitamura, Katia; Kobal, Ronaldo; Nakamura, Fábio Y

2016-07-01

To determine whether athletes from different sport disciplines present similar mean propulsive velocity (MPV) in the half-squat (HS) during submaximal and maximal tests, enabling prediction of 1-repetition maximum (1-RM) from MPV at any given submaximal load. Sixty-four male athletes, comprising American football, rugby, and soccer players; sprinters and jumpers; and combat-sport strikers attended 2 testing sessions separated by 2-4 wk. On the first visit, a standardized 1-RM test was performed. On the second, athletes performed HSs on Smith-machine equipment, using relative percentages of 1-RM to determine the respective MPV of submaximal and maximal loads. Linear regression established the relationship between MPV and percentage of 1-RM. A very strong linear relationship (R2 ≈ .96) was observed between the MPV and the percentages of HS 1-RM, resulting in the following equation: %HS 1-RM = -105.05 × MPV + 131.75. The MPV at HS 1-RM was ~0.3 m/s. This equation can be used to predict HS 1-RM on a Smith machine with a high degree of accuracy.

Do the flash-lag effect and representational momentum involve similar extrapolations?

PubMed Central

Hubbard, Timothy L.

2013-01-01

In the flash-lag effect (FLE) and in representational momentum (RM), the represented position of a moving target is displaced in the direction of motion. Effects of numerous variables on the FLE and on RM are briefly considered. In many cases, variables appear to have the same effect on the FLE and on RM, and this is consistent with a hypothesis that displacements in the FLE and in RM result from overlapping or similar mechanisms. In other cases, variables initially appear to have different effects on the FLE and on RM, but accounts reconciling those apparent differences with a hypothesis of overlapping or similar mechanisms are suggested. Given that RM is simpler and accounts for a wider range of findings (i.e., RM involves a single stimulus rather than the relationship between two stimuli, RM accounts for displacement in absolute position of a single stimulus and for differences in relative position of two stimuli), it is suggested that (at least some cases of) the FLE might be a special case of RM in which the position of the target is assessed relative to the position of another stimulus (i.e., the flashed object) rather than relative to the actual position of the target. PMID:23734140

Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133.

PubMed

Perreault, Martin; Maltais, René; Kenmogne, Lucie Carolle; Létourneau, Danny; LeHoux, Jean-Guy; Gobeil, Stéphane; Poirier, Donald

2018-02-01

The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties of the representative candidate RM-133 needs to be characterized. In vitro experiments were first used to determine that RM-133 causes apoptosis in cancer cells. Then, using proteomic and transcriptomic experiments, RM-133 cytotoxicity was proven to be achieved via the endoplasmic reticulum (ER)-related apoptosis, which characterizes RM-133 as an endoplasmic reticulum stress aggravator (ERSA) anticancer drug. Furthermore, an shRNA-genome-wide screening has permitted to identify the steroidogenic acute regulator-related lipid transfer protein 5 (STARD5) as a major player in the RM-133 ER-related apoptosis mechanism, which was validated by an in vitro binding experiment. Altogether, the results presented herein suggest that RM-133 provokes a disturbance of cholesterol homeostasis via the implication of STARD5, which delivers an ERSA molecule to the ER. These results will be a springboard for RM-133 in its path toward clinical use. Copyright © 2017 Elsevier Ltd. All rights reserved.

Association Analysis of Arsenic-Induced Straighthead in Rice (Oryza sativa L.) Based on the Selected Population with a Modified Model.

PubMed

Li, Xiaobai; Hu, Biaolin; Pan, Xuhao; Zhang, Ning; Wu, Dianxing

2017-01-01

A rice physiological disorder makes mature panicle keep erect with empty grains termed as "straighthead." Straighthead causes yield losses and is a serious threat to rice production worldwide. Here, a new study of association mapping was conducted to identify QTL involved in straighthead. A subset of 380 accessions was selected from the USDA rice core collection and genotyped with 72 genome-wide SSR markers. An optimal model implemented with principle components (PCs) was used in this association mapping. As a result, five markers were identified to be significantly associated with straighthead. Three of them, RM263, RM169, and RM224, were consistent with a previous study. Three markers, RM475, RM263, and RM19, had a resistant allele associated with a decrease in straighthead rating (straighthead rating ≤ 4.8). In contrast, the two other marker loci RM169 and RM224 had a few susceptible alleles associated with an increase in straighthead rating (straighthead rating ≥ 8.7). Interestingly, RM475 is close to QTL " qSH-2 " and " AsS " with straighthead resistance, which was reported in two studies on linkage mapping of straighthead. This finding adds to previous work and is useful for further genetic study of straighthead.

Validity of one-repetition maximum predictive equations in men with spinal cord injury.

PubMed

Ribeiro Neto, F; Guanais, P; Dornelas, E; Coutinho, A C B; Costa, R R G

2017-10-01

Cross-sectional study. The study aimed (a) to test the cross-validation of current one-repetition maximum (1RM) predictive equations in men with spinal cord injury (SCI); (b) to compare the current 1RM predictive equations to a newly developed equation based on the 4- to 12-repetition maximum test (4-12RM). SARAH Rehabilitation Hospital Network, Brasilia, Brazil. Forty-five men aged 28.0 years with SCI between C6 and L2 causing complete motor impairment were enrolled in the study. Volunteers were tested, in a random order, in 1RM test or 4-12RM with 2-3 interval days. Multiple regression analysis was used to generate an equation for predicting 1RM. There were no significant differences between 1RM test and the current predictive equations. ICC values were significant and were classified as excellent for all current predictive equations. The predictive equation of Lombardi presented the best Bland-Altman results (0.5 kg and 12.8 kg for mean difference and interval range around the differences, respectively). The two created equation models for 1RM demonstrated the same and a high adjusted R 2 (0.971, P<0.01), but different SEE of measured 1RM (2.88 kg or 5.4% and 2.90 kg or 5.5%). All 1RM predictive equations are accurate to assess individuals with SCI at the bench press exercise. However, the predictive equation of Lombardi presented the best associated cross-validity results. A specific 1RM prediction equation was also elaborated for individuals with SCI. The created equation should be tested in order to verify whether it presents better accuracy than the current ones.

Induction of taxol metabolism in the rat by dexamethasone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, C.D.; Gondi, K.N.; Walle, T.

1994-12-31

The antitumor drug taxol was metabolized to two major metabolites (RM1 and RM2) in adult male and female rat liver microsomes. The male rats produced RM1 2.6 fold faster than the females, and they produced RM2 3 fold faster than the females. This correlated well with the sex differences noticed in liver microsomal cytochrome P450 (CYP) 3A content (4.4 fold greater in male) and 6{beta}-hydroxylation of testosterone (2.4 fold greater in male). Taxol was metabolized to three major metabolites (RM1, RM2, and RM3) in adult male and female rat liver microsomes from rats pretreated with dexamethasone. Production of RM1 andmore » RM2 was increased in these rats (2.3 and 3.3 fold respectively in males; 6.5 and 8.7 fold respectively in females) as compared to the untreated rats. These results compared well with the induction of CYP 3A proteins (3.5 fold in male, 10 fold in female) and induction of 6{beta}-hydroxylation (1.9 fold in males, 3.8 fold in females). RM3, which was produced only by the rats pretreated with dexamethasone, had a retention time of 0.58 relative to taxol which corresponds to 6{alpha}- hydroxytaxol, the major human metabolite of taxol. This study indicates that taxol metabolism in the rat is likely due to CYP 3A enzymes. Although the evidence points toward CYP 3A1 as the major isoform involved, it does not rule out others. The findings also suggest that CYP 3A1 is responsible for the induced metabolite, RM3.« less

Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.

PubMed

Varzari, Alexander; Kharkov, Vladimir; Nikitin, Alexey G; Raicu, Florina; Simonova, Kseniya; Stephan, Wolfgang; Weiss, Elisabeth H; Stepanov, Vadim

2013-01-01

Moldova has a rich historical and cultural heritage, which may be reflected in the current genetic makeup of its population. To date, no comprehensive studies exist about the population genetic structure of modern Moldavians. To bridge this gap with respect to paternal lineages, we analyzed 37 binary and 17 multiallelic (STRs) polymorphisms on the non-recombining portion of the Y chromosome in 125 Moldavian males. In addition, 53 Ukrainians from eastern Moldova and 54 Romanians from the neighboring eastern Romania were typed using the same set of markers. In Moldavians, 19 Y chromosome haplogroups were identified, the most common being I-M423 (20.8%), R-M17* (17.6%), R-M458 (12.8%), E-v13 (8.8%), R-M269* and R-M412* (both 7.2%). In Romanians, 14 haplogroups were found including I-M423 (40.7%), R-M17* (16.7%), R-M405 (7.4%), E-v13 and R-M412* (both 5.6%). In Ukrainians, 13 haplogroups were identified including R-M17 (34.0%), I-M423 (20.8%), R-M269* (9.4%), N-M178, R-M458 and R-M73 (each 5.7%). Our results show that a significant majority of the Moldavian paternal gene pool belongs to eastern/central European and Balkan/eastern Mediterranean Y lineages. Phylogenetic and AMOVA analyses based on Y-STR loci also revealed that Moldavians are close to both eastern/central European and Balkan-Carpathian populations. The data correlate well with historical accounts and geographical location of the region and thus allow to hypothesize that extant Moldavian paternal genetic lineages arose from extensive recent admixture between genetically autochthonous populations of the Balkan-Carpathian zone and neighboring Slavic groups.

Fatty and lean red meat consumption in China: differential association with Chinese abdominal obesity

PubMed Central

Wang, Z.; Zhang, B.; Zhai, F.; Wang, H.; Zhang, J.; Du, W.; Su, C.; Zhang, J.; Jiang, H.; Popkin, B. M.

2014-01-01

Aim We examined the longitudinal association between red meat (RM) consumption and the risk of abdominal obesity in Chinese adults. Methods and results Our data are from 16,822 adults aged 18 to 75 in the China Health and Nutrition Survey from 1993 to 2011. We assessed RM intake with three 24-hour dietary recalls. We defined abdominal obesity as a waist circumference (WC) ≥ 85 centimeters (cm) for men and ≥ 80 cm for women. Multilevel mixed-effect regression models showed that men experienced WC increases of 0.74 cm (95% confidence interval [CI]: 0.39–1.09) from a higher total intake of fresh RM and 0.59 cm (95% CI: 0.24–0. 95) from a higher intake of fatty fresh RM but 0.14 cm (95% CI: −0.39–0.66) from a higher intake of lean fresh RM in the top versus the bottom quartile when adjusted for potential confounders. In contrast, after additional adjustment for baseline WC, the odds ratios of abdominal obesity in men were attenuated for total fresh RM (1.25 [95% CI: 1.06–1.47]) and fatty fresh RM (1.22 [95% CI: 1.03–1.44]) but were still not affected by lean fresh RM (0.95 [95% CI: 0.75–1.22]). Women also showed a positive association of fatty fresh RM intake with abdominal obesity. Conclusion Greater intake of fatty fresh RM was significantly associated with higher WC (men only) and abdominal obesity risk in Chinese adults. The gender-specific differential association of fatty versus lean fresh RM warrants further study. PMID:24795160

Fatty and lean red meat consumption in China: differential association with Chinese abdominal obesity.

PubMed

Wang, Z; Zhang, B; Zhai, F; Wang, H; Zhang, J; Du, W; Su, C; Zhang, J; Jiang, H; Popkin, B M

2014-08-01

We examined the longitudinal association between red meat (RM) consumption and the risk of abdominal obesity in Chinese adults. Our data are from 16,822 adults aged 18-75 in the China Health and Nutrition Survey from 1993 to 2011. We assessed RM intake with three 24-h dietary recalls. We defined abdominal obesity as a waist circumference (WC) ≥85 centimeters (cm) for men and ≥80 cm for women. Multilevel mixed-effect regression models showed that men experienced WC increases of 0.74 cm (95% confidence interval [CI]: 0.39-1.09) from a higher total intake of fresh RM and 0.59 cm (95% CI: 0.24-0. 95) from a higher intake of fatty fresh RM but 0.14 cm (95% CI: -0.39 to 0.66) from a higher intake of lean fresh RM in the top quartile versus non-consumers when adjusted for potential confounders. In contrast, after additional adjustment for baseline WC, the odds ratios of abdominal obesity in men were attenuated for total fresh RM (1.25 [95% CI: 1.06-1.47]) and fatty fresh RM (1.22 [95% CI: 1.03-1.44]) but were still not affected by lean fresh RM (0.95 [95% CI: 0.75-1.22]). Women also showed a positive association of fatty fresh RM intake with abdominal obesity. Greater intake of fatty fresh RM was significantly associated with higher WC (men only) and abdominal obesity risk in Chinese adults. The gender-specific differential association of fatty versus lean fresh RM warrants further study. Copyright © 2014 Elsevier B.V. All rights reserved.

Steroid isotopic standards for gas chromatography-combustion isotope ratio mass spectrometry (GCC-IRMS).

PubMed

Zhang, Ying; Tobias, Herbert J; Brenna, J Thomas

2009-03-01

Carbon isotope ratio (CIR) analysis of urinary steroids using gas chromatography-combustion isotope ratio mass spectrometry (GCC-IRMS) is a recognized test to detect illicit doping with synthetic testosterone. There are currently no universally used steroid isotopic standards (SIS). We adapted a protocol to prepare isotopically uniform steroids for use as a calibrant in GCC-IRMS that can be analyzed under the same conditions as used for steroids extracted from urine. Two separate SIS containing a mixture of steroids were created and coded CU/USADA 33-1 and CU/USADA 34-1, containing acetates and native steroids, respectively. CU/USADA 33-1 contains 5alpha-androstan-3beta-ol acetate (5alpha-A-AC), 5alpha-androstan-3alpha-ol-17-one acetate (androsterone acetate, A-AC), 5beta-androstan-3alpha-ol-11, 17-dione acetate (11-ketoetiocholanolone acetate, 11k-AC) and 5alpha-cholestane (Cne). CU/USADA 34-1 contains 5beta-androstan-3alpha-ol-17-one (etiocholanolone, E), 5alpha-androstan-3alpha-ol-17-one (androsterone, A), and 5beta-pregnane-3alpha, 20alpha-diol (5betaP). Each mixture was prepared and dispensed into a set of about 100 ampoules using a protocol carefully designed to minimize isotopic fractionation and contamination. A natural gas reference material, NIST RM 8559, traceable to the international standard Vienna PeeDee Belemnite (VPDB) was used to calibrate the SIS. Absolute delta(13)C(VPDB) and Deltadelta(13)C(VPDB) values from randomly selected ampoules from both SIS indicate uniformity of steroid isotopic composition within measurement reproducibility, SD(delta(13)C)<0.2 per thousand. This procedure for creation of isotopic steroid mixtures results in consistent standards with isotope ratios traceable to the relevant international reference material.

EDXRF as an alternative method for multielement analysis of tropical soils and sediments.

PubMed

Fernández, Zahily Herrero; Dos Santos Júnior, José Araújo; Dos Santos Amaral, Romilton; Alvarez, Juan Reinaldo Estevez; da Silva, Edvane Borges; De França, Elvis Joacir; Menezes, Rômulo Simões Cezar; de Farias, Emerson Emiliano Gualberto; do Nascimento Santos, Josineide Marques

2017-08-10

The quality assessment of tropical soils and sediments is still under discussion, with efforts being made on the part of governmental agencies to establish reference values. Energy dispersive X-ray fluorescence (EDXRF) is a potential analytical technique for quantifying diverse chemical elements in geological material without chemical treatment, primarily when it is performed at an appropriate metrological level. In this work, analytical curves were obtained by means of the analysis of geological reference materials (RMs), which allowed for the researchers to draw a comparison among the sources of analytical uncertainty. After having determined the quality assurance of the analytical procedure, the EDXRF method was applied to determine chemical elements in soils from the state of Pernambuco, Brazil. The regression coefficients of the analytical curves used to determine Al, Ca, Fe, K, Mg, Mn, Ni, Pb, Si, Sr, Ti, and Zn were higher than 0.99. The quality of the analytical procedure was demonstrated at a 95% confidence level, in which the estimated analytical uncertainties agreed with those from the RM's certificates of analysis. The analysis of diverse geological samples from Pernambuco indicated higher concentrations of Ni and Zn in sugarcane, with maximum values of 41 mg kg - 1 and 118 mg kg - 1 , respectively, and agricultural areas (41 mg kg - 1 and 127 mg kg - 1 , respectively). The trace element Sr was mainly enriched in urban soils with values of 400 mg kg - 1 . According to the results, the EDXRF method was successfully implemented, providing some chemical tracers for the quality assessment of tropical soils and sediments.

Impact of remote monitoring on clinical events and associated health care utilization: A nationwide assessment.

PubMed

Piccini, Jonathan P; Mittal, Suneet; Snell, Jeff; Prillinger, Julie B; Dalal, Nirav; Varma, Niraj

2016-12-01

Remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) improves patient survival. However, whether RM reduces health care utilization is unknown. The purpose of this study was to determine whether RM was associated with reduced hospitalization and costs in clinical practice. We conducted a nationwide cohort study using the Truven Health Analytics MarketScan database. Patients implanted with a CIED between March 31, 2009, and April 1, 2012, were included. All-cause hospitalization events were compared between those using RM and those not using RM by using Cox proportional hazards methods with Andersen-Gill extension and propensity scoring. We also compared health care costs (payments >30 days after CIED implantation). Overall, there were 92,566 patients (mean age 72 ± 13 years; 58,140 [63%] men) with a mean follow-up of 19 ± 12 months, including 54,520 (59%) pacemaker, 27,816 (30%) implantable cardioverter-defibrillator, and 10,230 (11%) cardiac resynchronization therapy patients. Only 37% of patients (34,259) used RM. Patients with RM had Charlson Comorbidity Index values similar to those not using RM but had lower adjusted risk of all-cause hospitalization (adjusted hazard ratio 0.82; 95% confidence interval 0.80-0.84; P < .001) and shorter mean length of hospitalization (5.3 days vs 8.1 days; P < .001) during follow-up. RM was associated with a 30% reduction in hospitalization costs ($8720 mean cost per patient-year vs $12,423 mean cost per patient-year). For every 100,000 patient-years of follow-up, RM was associated with 9810 fewer hospitalizations, 119,000 fewer days in hospital, and $370,270,000 lower hospital payments. RM is associated with reductions in hospitalization and health care utilization. Since only about a third of patients with CIEDs routinely use RM, this represents a major opportunity for quality improvement. Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Open lung approach versus standard protective strategies: Effects on driving pressure and ventilatory efficiency during anesthesia - A pilot, randomized controlled trial.

PubMed

Ferrando, Carlos; Suarez-Sipmann, Fernando; Tusman, Gerardo; León, Irene; Romero, Esther; Gracia, Estefania; Mugarra, Ana; Arocas, Blanca; Pozo, Natividad; Soro, Marina; Belda, Francisco J

2017-01-01

Low tidal volume (VT) during anesthesia minimizes lung injury but may be associated to a decrease in functional lung volume impairing lung mechanics and efficiency. Lung recruitment (RM) can restore lung volume but this may critically depend on the post-RM selected PEEP. This study was a randomized, two parallel arm, open study whose primary outcome was to compare the effects on driving pressure of adding a RM to low-VT ventilation, with or without an individualized post-RM PEEP in patients without known previous lung disease during anesthesia. Consecutive patients scheduled for major abdominal surgery were submitted to low-VT ventilation (6 ml·kg-1) and standard PEEP of 5 cmH2O (pre-RM, n = 36). After 30 min estabilization all patients received a RM and were randomly allocated to either continue with the same PEEP (RM-5 group, n = 18) or to an individualized open-lung PEEP (OL-PEEP) (Open Lung Approach, OLA group, n = 18) defined as the level resulting in maximal Cdyn during a decremental PEEP trial. We compared the effects on driving pressure and lung efficiency measured by volumetric capnography. OL-PEEP was found at 8±2 cmH2O. 36 patients were included in the final analysis. When compared with pre-RM, OLA resulted in a 22% increase in compliance and a 28% decrease in driving pressure when compared to pre-RM. These parameters did not improve in the RM-5. The trend of the DP was significantly different between the OLA and RM-5 groups (p = 0.002). VDalv/VTalv was significantly lower in the OLA group after the RM (p = 0.035). Lung recruitment applied during low-VT ventilation improves driving pressure and lung efficiency only when applied as an open-lung strategy with an individualized PEEP in patients without lung diseases undergoing major abdominal surgery. ClinicalTrials.gov NCT02798133.

Behavior of restriction–modification systems as selfish mobile elements and their impact on genome evolution

PubMed Central

Kobayashi, Ichizo

2001-01-01

Restriction–modification (RM) systems are composed of genes that encode a restriction enzyme and a modification methylase. RM systems sometimes behave as discrete units of life, like viruses and transposons. RM complexes attack invading DNA that has not been properly modified and thus may serve as a tool of defense for bacterial cells. However, any threat to their maintenance, such as a challenge by a competing genetic element (an incompatible plasmid or an allelic homologous stretch of DNA, for example) can lead to cell death through restriction breakage in the genome. This post-segregational or post-disturbance cell killing may provide the RM complexes (and any DNA linked with them) with a competitive advantage. There is evidence that they have undergone extensive horizontal transfer between genomes, as inferred from their sequence homology, codon usage bias and GC content difference. They are often linked with mobile genetic elements such as plasmids, viruses, transposons and integrons. The comparison of closely related bacterial genomes also suggests that, at times, RM genes themselves behave as mobile elements and cause genome rearrangements. Indeed some bacterial genomes that survived post-disturbance attack by an RM gene complex in the laboratory have experienced genome rearrangements. The avoidance of some restriction sites by bacterial genomes may result from selection by past restriction attacks. Both bacteriophages and bacteria also appear to use homologous recombination to cope with the selfish behavior of RM systems. RM systems compete with each other in several ways. One is competition for recognition sequences in post-segregational killing. Another is super-infection exclusion, that is, the killing of the cell carrying an RM system when it is infected with another RM system of the same regulatory specificity but of a different sequence specificity. The capacity of RM systems to act as selfish, mobile genetic elements may underlie the structure and function of RM enzymes. PMID:11557807

Behavior of restriction-modification systems as selfish mobile elements and their impact on genome evolution.

PubMed

Kobayashi, I

2001-09-15

Restriction-modification (RM) systems are composed of genes that encode a restriction enzyme and a modification methylase. RM systems sometimes behave as discrete units of life, like viruses and transposons. RM complexes attack invading DNA that has not been properly modified and thus may serve as a tool of defense for bacterial cells. However, any threat to their maintenance, such as a challenge by a competing genetic element (an incompatible plasmid or an allelic homologous stretch of DNA, for example) can lead to cell death through restriction breakage in the genome. This post-segregational or post-disturbance cell killing may provide the RM complexes (and any DNA linked with them) with a competitive advantage. There is evidence that they have undergone extensive horizontal transfer between genomes, as inferred from their sequence homology, codon usage bias and GC content difference. They are often linked with mobile genetic elements such as plasmids, viruses, transposons and integrons. The comparison of closely related bacterial genomes also suggests that, at times, RM genes themselves behave as mobile elements and cause genome rearrangements. Indeed some bacterial genomes that survived post-disturbance attack by an RM gene complex in the laboratory have experienced genome rearrangements. The avoidance of some restriction sites by bacterial genomes may result from selection by past restriction attacks. Both bacteriophages and bacteria also appear to use homologous recombination to cope with the selfish behavior of RM systems. RM systems compete with each other in several ways. One is competition for recognition sequences in post-segregational killing. Another is super-infection exclusion, that is, the killing of the cell carrying an RM system when it is infected with another RM system of the same regulatory specificity but of a different sequence specificity. The capacity of RM systems to act as selfish, mobile genetic elements may underlie the structure and function of RM enzymes.

Strength, power, and muscular endurance exercise and elite rowing ergometer performance.

PubMed

Lawton, Trent W; Cronin, John B; McGuigan, Michael R

2013-07-01

Knowledge of the relationship between weight room exercises and various rowing performance measures is limited; this information would prove useful for sport-specific assessment of individual needs and exercise prescription. The purpose of this study was to establish strength, power, and muscular endurance exercises for weight room training, which are strong determinants of success in specific performance measures used to assess elite rowers. Nineteen heavyweight elite males determined their repetition maximum (RM) loads for exercises using a Concept 2 DYNO [5, 30, 60 and 120RM leg pressing and seated arm pulling (in Joules)] and free weights [1RM power clean (in kilograms) and 6RM bench pull (in kilograms and watts)]. Rowing performance measures included a 7-stage blood lactate response ergometer test (aerobic condition), time trials (500, 2000, and 5000 m), a peak stroke power test, and a 60-minute distance trial. Pearson correlation moments (r ≥ 0.7) and stepwise multiple linear regression calculations (R ≥ 50%) were used to establish strong common variances between weight room exercises and rowing ergometer performance (p ≤ 0.05). Weight room exercises were strong predictors of 2000-m, 500-m time (in seconds), and peak stroke power performance measures only. Bench pull power (in watts) and 1RM power clean (in kilograms) were the best 2-factor predictors of peak stroke power (R = 73%; standard error of the estimates [SEE] = 59.6 W) and 500 m (R = 70%; SEE = 1.75 seconds); while 5RM leg pressing (in Joules) and either 6RM bench pull (kg) or 60RM seated arm pulling (in Joules) the best predictors of 2000 m (R = 59%; SEE = 6.3 seconds and R = 57%; SEE = 6.4 seconds, respectively). Recommended exercises for weight room training include a 1RM power clean, 6RM bench pull, 5RM leg press, and 60RM seated arm pulling.

Economic analysis of remote monitoring of cardiac implantable electronic devices: Results of the Health Economics Evaluation Registry for Remote Follow-up (TARIFF) study.

PubMed

Ricci, Renato Pietro; Vicentini, Alfredo; D'Onofrio, Antonio; Sagone, Antonio; Rovaris, Giovanni; Padeletti, Luigi; Morichelli, Loredana; Fusco, Antonio; De Vivo, Stefano; Lombardi, Leonida; Denaro, Alessandra; Pollastrelli, Annalisa; Colangelo, Irene; Santini, Massimo

2017-01-01

Remote monitoring (RM) of cardiac implantable electronic devices has been demonstrated to improve outpatient clinic workflow and patient management. However, few data are available on the socioeconomic impact of RM. The aim of this study was to assess the costs and benefits of RM compared with standard care (SC). We used 12-month patient data from the Health Economics Evaluation Registry for Remote Follow-up (TARIFF) study (N = 209; RM: n = 102 (48.81%); SC: n = 107 (51.19%)). Cost comparison was made from 2 perspectives: the health care system (HCS) and patients. The use of health care resources was defined on the basis of hospital clinical folders. Out-of-pocket expenses were reported directly by patients. HCS perspective: The overall mean annual cost per patient in the SC group (€1044.89 ± €1990.47) was significantly higher than in the RM group (€482.87 ± €2488.10) (P < .0001), with a reduction of 53.87% being achieved in the RM group. The primary driver of cost reduction was the cost of cardiovascular hospitalizations (SC: €`886.67 ± €1979.13 vs RM: €432.34 ± €2488.10; P = .0030). Patient and caregiver perspective: The annual cost incurred by patients was significantly higher in the SC group than in the RM group (SC: €169.49 ± €189.50 vs RM: €56.87 ± €80.22; P < .0001). Patients' quality-adjusted life-years were not significantly different between the groups. Provider perspective: The total number of inhospital device follow-up visits was reduced by 58.78% in the RM group. RM of patients with cardiac implantable electronic devices (CIEDs) is cost saving from the perspectives of the HCS, patients, and caregivers. Introducing appropriate reimbursements will make RM sustainable even for the provider, i.e. the hospitals which provide the service and encourage widespread adoption of RM. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Complete genome sequence of Campylobacter jejuni RM1246-ERRC that exhibits resistance to Quaternary Ammonium Compounds

USDA-ARS?s Scientific Manuscript database

Campylobacter jejuni strain RM1246-ERRC is a clinical isolate. In laboratory experiments RM1246-ERRC exhibited resistance to the antimicrobial effects of quaternary ammonium compounds (QACs) when compared to other C. jejuni strains. The chromosome of RM1246-ERRC was determined to be 1,659,694 bp w...

76 FR 37682 - Airworthiness Directives; Teledyne Continental Motors (TCM) and Rolls-Royce Motors Ltd. (R-RM...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... Continental Motors (TCM) and Rolls-Royce Motors Ltd. (R-RM) Series Reciprocating Engines AGENCY: Federal... supersede an existing airworthiness directive (AD) that applies to certain TCM and R-RM series reciprocating... range of magneto S/ Ns affected, and of the need to include certain engines made by R-RM, under license...

76 FR 78808 - Airworthiness Directives; Teledyne Continental Motors (TCM) and Rolls-Royce Motors Ltd. (R-RM...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-20

... Airworthiness Directives; Teledyne Continental Motors (TCM) and Rolls-Royce Motors Ltd. (R-RM) Series... superseding an existing airworthiness directive (AD) for certain TCM and R-RM series reciprocating engines... adds R-RM C-125, C- 145, O-300, IO-360, TSIO-360, and LTSIO-520-AE series reciprocating engines to the...

Can the job content questionnaire be used to assess structural and organizational properties of the work environment?

PubMed

Persson, Roger; Hansen, Åse Marie; Garde, Anne Helene; Kristiansen, Jesper; Nordander, Catarina; Balogh, Istvan; Ohlsson, Kerstina; Ostergren, Per-Olof; Ørbæk, Palle

2012-01-01

The theory behind the Job Content Questionnaire (JCQ) presumes that the "objective" social environment is measurable via self-report inventories such as the JCQ. Hence, it is expected that workers in identical work will respond highly similar. However, since no studies have evaluated this basic assumption, we decided to investigate whether workers performing highly similar work also responded similarly to the JCQ. JCQ data from a rubber-manufacturing (RM: n = 95) and a mechanical assembly company (MA: n = 119) were examined. On each worksite, men and women performed identical machine-paced job tasks. A population sample (n = 8,542) served as a reference group. In both the RM and MA groups, the job support questions were rated most similar. Yet, there was a substantial variation as regards choosing to agree or disagree with single JCQ items. The variation was also reflected in the scale scores. In the RM and MA groups, the variance of job demand and job control scores was 64-87% of that of the population sample. For job support scores, the corresponding variation was 42-87%. Conducting highly similar work does not lead to highly similar reports in the JCQ. In view of the large response variation, it seems that the attempt to avoid personal influence by minimizing the self-reflexive component in the questions asked, and using response alternative that indicates degree of agreement, does not seem to work as intended.

Proceeding of the 1999 Particle Accelerator Conference. Volume 4

DTIC Science & Technology

1999-04-02

III M.L. Furste, R.M. Graves, A. Hamilton, L.R. Hughey, R.P. Madden’, R.E. Vest, NIST, Gaithersburg, MD, W.S. Trzeciak, R.A. Bosch , Synchrotron...1999 INFRARED EDGE RADIATION BEAMLINE AT ALADDIN T. E. May, R. A. Bosch and R. L. Julian, Synchrotron Radiation Center, University of Wisconsin-Madison...enhanced. The amide I profile 5 REFERENCES 0.3 liqu phase [1] M. A. Green, R. A. Bosch and W. S. Trzeciak, "Study of radiation 0.2- along the

Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury

DTIC Science & Technology

2016-02-01

2011;105:143-50. 11. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005;26:319-38. 12. Crapo RO, Morris AH, Gardner...profile in persons with chronic motor complete spinal cord injury. J Spinal Cord Med 2010;33:6-15. 22. Crapo RO, Morris AH, Gardner RM. Reference...blood pressure was checked and found to be over 140 or less than 80 systolic SUNDAY MONDAY TUESDAY WEDNESDAY FRIDAY THURSDAY SATURDAY LUNG LUNG LUNG

Identification of G-Protein-Coupled Receptors (GPCRs) in Pulmonary Artery Smooth Muscle Cells as Novel Therapeutic Targets

DTIC Science & Technology

2015-10-01

Michkov AV, Lynch RM, Overland AC, Corriden R. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic...M. Chinn, Alexander V. Michkov, Rebecca M. Lynch , Aaron C. Overland, and Ross Corriden Departments of Pharmacology (P.A.I., A.W., A.C.Z., A.N.S., N.A...Sriram, Chinn, Michkov, Lynch , Overland, Corriden. References Ahmad R, Wojciech S, Jockers R (2014) Hunting for the function of orphan GPCRs - beyond

Anthropometric Cockpit Compatibility Assessment of US Army Aircraft for Large and Small Personnel Wearing a Training, Warm-Weather Clothing Configuration

DTIC Science & Technology

1984-07-01

SUPPLEMENTARY NOTES 19. KEY WORDS (Continue on rover&* side If necessary and Identify by block number) Anthropometry , Cockpit Compatibility, Aircraft...report is one of a series of reports on anthropometry in US Army Aviation produced by the US Army Aeromedical Research Laboratory (USAARL...and stick (OV-1D). 4 , 26 *w. I.. REFERENCES Churchill, E., Churchill, T., McConville, J.T., and White, R.M. 1977. Anthropometry of women of the U.S

A Lightweight Intelligent Virtual Cinematography System for Machinima Production

DTIC Science & Technology

2007-01-01

portmanteau of machine and cinema , machinima refers to the innovation of leveraging video game technology to greatly ease the creation of computer...selecting camera angles to capture the action of an a priori unknown script as aesthetically appropriate cinema . There are a number of challenges therein...Proc. of the 4th International Conf. on Autonomous Agents. Young, R.M. and Riedl, M.O. 2003. Towards an Architecture for Intelligent Control of Narrative in Interactive Virtual Worlds. In Proc. of IUI 2003.

Implantable Sensors for Regenerative Medicine

PubMed Central

Klosterhoff, Brett S.; Tsang, Melissa; She, Didi; Ong, Keat Ghee; Allen, Mark G.; Willett, Nick J.; Guldberg, Robert E.

2017-01-01

The translation of many tissue engineering/regenerative medicine (TE/RM) therapies that demonstrate promise in vitro are delayed or abandoned due to reduced and inconsistent efficacy when implemented in more complex and clinically relevant preclinical in vivo models. Determining mechanistic reasons for impaired treatment efficacy is challenging after a regenerative therapy is implanted due to technical limitations in longitudinally measuring the progression of key environmental cues in vivo. The ability to acquire real-time measurements of environmental parameters of interest including strain, pressure, pH, temperature, oxygen tension, and specific biomarkers within the regenerative niche in situ would significantly enhance the information available to tissue engineers to monitor and evaluate mechanisms of functional healing or lack thereof. Continued advancements in material and fabrication technologies utilized by microelectromechanical systems (MEMSs) and the unique physical characteristics of passive magnetoelastic sensor platforms have created an opportunity to implant small, flexible, low-power sensors into preclinical in vivo models, and quantitatively measure environmental cues throughout healing. In this perspective article, we discuss the need for longitudinal measurements in TE/RM research, technical progress in MEMS and magnetoelastic approaches to implantable sensors, the potential application of implantable sensors to benefit preclinical TE/RM research, and the future directions of collaborative efforts at the intersection of these two important fields. PMID:27987300

The Cost and Utility of Renal Transplantation in Malaysia.

PubMed

Bavanandan, Sunita; Yap, Yok-Chin; Ahmad, Ghazali; Wong, Hin-Seng; Azmi, Soraya; Goh, Adrian

2015-11-01

Kidney transplantation is the optimal therapy for the majority of patients with end-stage renal disease. However, the cost and health outcomes of transplantation have not been assessed in a middle-income nation with a low volume of transplantation, such as Malaysia. This study used microcosting methods to determine the cost and health outcomes of living and deceased donor kidney transplantation in adult and pediatric recipients. The perspective used was from the Ministry of Health Malaysia. Cost-effectiveness measures were cost per life year (LY) and cost per quality-adjusted LYs. The time horizon was the lifetime of the transplant recipient from transplant to death. Records of 206 KT recipients (118 adults and 88 children) were obtained for microcosting. In adults, discounted cost per LY was US $8609(Malaysian Ringgit [RM]29 482) and US $13 209(RM45 234) for living-donor kidney transplant (LKT) and deceased donor kidney transplant (DKT), respectively, whereas in children, it was US $10 485(RM35 905) and US $14 985(RM51 317), respectively. Cost per quality-adjusted LY in adults was US $8826 (RM30 224) for LKT and US $13 592(RM46 546) for DKT. Total lifetime discounted costs of adult transplants were US $119 702 (RM409 921) for LKT, US $147 152 (RM503 922) for DKT. Total costs for pediatric transplants were US $154 841(RM530 252) and US $159 313(RM545 566) for the 2 categories respectively. Both LKT and DKT are economically favorable for Malaysian adult and pediatric patients with ESRD and result in improvement in quality of life.

Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice.

PubMed

Gonzales, G F; Gasco, M; Malheiros-Pereira, A; Gonzales-Castañeda, C

2008-06-01

The plants from the Lepidium gender have demonstrated to have effect on the size of the prostate. Lepidium meyenii (Maca) is a Peruvian plant that grows exclusively over 4000 m above sea level. The present study was designed to determine the effect of red maca (RM) in the prostate hyperplasia induced with testosterone enanthate (TE) in adult mice. Prostate hyperplasia was induced by administering TE, and then these animals (n = 6, each group) were treated with RM or Finasteride (positive control) for 21 days. There was an additional group without prostate hyperplasia (vehicle). Mice were killed on days 7, 14 and 21 after treatment with RM. Testosterone and oestradiol levels were measured on the last day of treatment. Prostatic stroma, epithelium and acini were measured histologically. RM reduced prostate weight at 21 days of treatment. Weights of seminal vesicles, testis and epididymis were not affected by RM treatment. The reduction in prostate size by RM was 1.59 times. Histological analysis showed that TE increased 2-fold the acinar area, effect prevented in the groups receiving TE + RM for 14 (P < 0.05) and 21 (P < 0.05) days and the group receiving TE + Finasteride for 21 days (P < 0.05). TE increased prostatic stroma area and this effect was prevented by treatment with RM since 7 days of treatment or Finasteride. The reduction in prostatic stroma area by RM was 1.42 times. RM has an anti-hyperplastic effect on the prostate of adult mice when hyperplasia was induced with TE acting first at prostatic stromal level.

Predicting the Maximum Dynamic Strength in Bench Press: The High Precision of the Bar Velocity Approach.

PubMed

Loturco, Irineu; Kobal, Ronaldo; Moraes, José E; Kitamura, Katia; Cal Abad, César C; Pereira, Lucas A; Nakamura, Fábio Y

2017-04-01

Loturco, I, Kobal, R, Moraes, JE, Kitamura, K, Cal Abad, CC, Pereira, LA, and Nakamura, FY. Predicting the maximum dynamic strength in bench press: the high precision of the bar velocity approach. J Strength Cond Res 31(4): 1127-1131, 2017-The aim of this study was to determine the force-velocity relationship and test the possibility of determining the 1 repetition maximum (1RM) in "free weight" and Smith machine bench presses. Thirty-six male top-level athletes from 3 different sports were submitted to a standardized 1RM bench press assessment (free weight or Smith machine, in randomized order), following standard procedures encompassing lifts performed at 40-100% of 1RM. The mean propulsive velocity (MPV) was measured in all attempts. A linear regression was performed to establish the relationships between bar velocities and 1RM percentages. The actual and predicted 1RM for each exercise were compared using a paired t-test. Although the Smith machine 1RM was higher (10% difference) than the free weight 1RM, in both cases the actual and predicted values did not differ. In addition, the linear relationship between MPV and percentage of 1RM (coefficient of determination ≥95%) allow determination of training intensity based on the bar velocity. The linear relationships between the MPVs and the relative percentages of 1RM throughout the entire range of loads enable coaches to use the MPV to accurately monitor their athletes on a daily basis and accurately determine their actual 1RM without the need to perform standard maximum dynamic strength assessments.

Effect of surface stability on core muscle activity for dynamic resistance exercises.

PubMed

Willardson, Jeffrey M; Fontana, Fabio E; Bressel, Eadric

2009-03-01

To compare core muscle activity during resistance exercises performed on stable ground vs. the BOSU Balance Trainer. Twelve trained men performed the back squat, dead lift, overhead press, and curl lifts. The activity of the rectus abdominis, external oblique abdominis, transversus abdominis/internal oblique abdominis, and erector spinae muscles was assessed. Subjects performed each lift under three separate conditions including standing on stable ground with 50% of a 1-RM, standing on a BOSU Balance Trainer with 50% of a 1-RM, and standing on stable ground with 75% of a 1-RM. Significant differences were noted between the stable 75% of 1-RM and BOSU 50% of 1-RM conditions for the rectus abdominis during the overhead press and transversus abdominis/internal oblique abdominis during the overhead press and curl (P < .05). Conversely, there were no significant differences between the stable 75% of 1-RM and BOSU 50% of 1-RM conditions for the external obliques and erector spinae across all lifts examined. Furthermore, there were no significant differences between the BOSU 50% of 1-RM and stable 50% of 1-RM conditions across all muscles and lifts examined. The current study did not demonstrate any advantage in utilizing the BOSU Balance Trainer. Therefore, fitness trainers should be advised that each of the aforementioned lifts can be performed while standing on stable ground without losing the potential core muscle training benefits.

An effective novel delivery strategy of rasagiline for Parkinson's disease.

PubMed

Fernández, Marcos; Negro, Sofía; Slowing, Karla; Fernández-Carballido, Ana; Barcia, Emilia

2011-10-31

This is the first report on the efficacy of a new controlled release system developed for rasagiline mesylate (RM) in a rotenone-induced rat model of Parkinson's disease (PD). PLGA microspheres in vitro released RM at a constant rate of 62.3 μg/day for two weeks. Intraperitoneal injection of rotenone (2 mg/kg/day) to Wistar rats produced typical PD symptoms. Catalepsy, akinesia and swim tests outcomes in animals receiving RM either in solution or within microspheres showed a reversal in descent latency when compared to rotenone-treated animals, being this reversal specially pronounced in animals receiving RM microspheres (dose equivalent to 1 mg/kg/day RM injected i.p. every 15 days). Nissl-staining of brain sections showed selective degeneration of the substantia nigra (SNc) dopaminergic neurons in rotenone-treated animals which was markedly reverted by RM microspheres. PET/CT with (18)F-DG resulted in mean increases of accumulation of radiotracer in striatum and SNc of around 40% in animals treated with RM microspheres which also had significant beneficial effects on Bcl-2, Bax, TNF-α mRNA and SOD2 levels as detected by real-time RT-PCR. Our results confirm the robust effect achieved by the new controlled release system developed for RM which exhibited better in vivo efficacy than RM given in solution. Copyright © 2011 Elsevier B.V. All rights reserved.

Predicting maximal strength in trained postmenopausal woman.

PubMed

Kemmler, Wolfgang K; Lauber, Dirk; Wassermann, Alfred; Mayhew, Jerry L

2006-11-01

The purpose of this study was to present an equation that accurately predicts 1 repetition maximum (RM) over a wide range of repetitions to fatigue (RTF) for 4 different machine resistance exercises in postmenopausal women. Seventy trained women (age = 57.4 +/- 3.1 years) performed maximal and submaximal repetitions on leg press, bench press, rowing, and leg adduction machines at the conclusion of a 2-year training program. Maximal repetitions were performed on each exercise in the following ranges: 3-5RM, 6-10RM, 11-15RM, and 16-20RM. Special regard was taken to maintain the identical execution of each test (i.e., range of motion, starting angle, speed of movement). One cubic polynomial (w(i) [0.988-0.0000584 r(i)(3) + 0.00190 r(i)(2) + 0.0104 r(i),] where w(i) is the load of measurement I, and r(i) is the number of repetitions) accurately predicted 1RM from RTF with mean absolute differences between actual 1RM and predicted 1RM for the 4 exercises of 1.5-3.1% and with coefficients of variation of <3.3%. Equation accuracy was independent of the exercise type or the number of RTF. Thus, this study supported the validity of RTF to adequately estimate 1RM over a wide range of repetitions and within different exercises in trained, older female subjects.

First Measurement of the Beam Normal Single Spin Asymmetry in $Δ$ Resonance Production by $$Q_{\\rm weak}$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuruzzaman, nfn

The beam normal single spin asymmetry (more » $$B_{\\rm n}$$) is generated in the scattering of transversely polarized electrons from unpolarized nuclei. The asymmetry arises from the interference of the imaginary part of the two-photon exchange with the one-photon exchange amplitude. The $$Q_{\\rm weak}$$ experiment has made the first measurement of $$B_{\\rm n}$$ in the production of the $$\\Delta$$(1232) resonance, using the $$Q_{\\rm weak}$$ apparatus in Hall-C at the Thomas Jefferson National Accelerator Facility. The final transverse asymmetry, corrected for backgrounds and beam polarization, is $$B_{\\rm n}$$ = 43 $$\\pm$$ 16 ppm at beam energy 1.16 GeV at an average scattering angle of about 8.3 degrees, and invariant mass of 1.2 GeV. The measured preliminary $$B_{\\rm n}$$ agrees with a preliminary theoretical calculation. $$B_{\\rm n}$$ for the $$\\Delta$$ is the only known observable that is sensitive to the $$\\Delta$$ elastic form-factors ($$\\gamma$$*$$\\Delta\\Delta$$) in addition to the generally studied transition form-factors ($$\\gamma$$*N$$\\Delta$$), but extracting this information will require significant theoretical input.« less

INTERPRETATION OF THE STRUCTURE FUNCTION OF ROTATION MEASURE IN THE INTERSTELLAR MEDIUM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Siyao; Zhang, Bing, E-mail: syxu@pku.edu.cn, E-mail: zhang@physics.unlv.edu

2016-06-20

The observed structure function (SF) of rotation measure (RM) varies as a broken power-law function of angular scales. The systematic shallowness of its spectral slope is inconsistent with the standard Kolmogorov scaling. This motivates us to examine the statistical analysis on RM fluctuations. The correlations of RM constructed by Lazarian and Pogosyan are demonstrated to be adequate in explaining the observed features of RM SFs through a direct comparison between the theoretically obtained and observationally measured SF results. By segregating the density and magnetic field fluctuations and adopting arbitrary indices for their respective power spectra, we find that when themore » SFs of RM and emission measure have a similar form over the same range of angular scales, the statistics of the RM fluctuations reflect the properties of density fluctuations. RM SFs can be used to evaluate the mean magnetic field along the line of sight, but cannot serve as an informative source on the properties of turbulent magnetic field in the interstellar medium. We identify the spectral break of RM SFs as the inner scale of a shallow spectrum of electron density fluctuations, which characterizes the typical size of discrete electron density structures in the observed region.« less

Impact of Measurement Uncertainties on Receptor Modeling of Speciated Atmospheric Mercury.

PubMed

Cheng, I; Zhang, L; Xu, X

2016-02-09

Gaseous oxidized mercury (GOM) and particle-bound mercury (PBM) measurement uncertainties could potentially affect the analysis and modeling of atmospheric mercury. This study investigated the impact of GOM measurement uncertainties on Principal Components Analysis (PCA), Absolute Principal Component Scores (APCS), and Concentration-Weighted Trajectory (CWT) receptor modeling results. The atmospheric mercury data input into these receptor models were modified by combining GOM and PBM into a single reactive mercury (RM) parameter and excluding low GOM measurements to improve the data quality. PCA and APCS results derived from RM or excluding low GOM measurements were similar to those in previous studies, except for a non-unique component and an additional component extracted from the RM dataset. The percent variance explained by the major components from a previous study differed slightly compared to RM and excluding low GOM measurements. CWT results were more sensitive to the input of RM than GOM excluding low measurements. Larger discrepancies were found between RM and GOM source regions than those between RM and PBM. Depending on the season, CWT source regions of RM differed by 40-61% compared to GOM from a previous study. No improvement in correlations between CWT results and anthropogenic mercury emissions were found.

Impact of Measurement Uncertainties on Receptor Modeling of Speciated Atmospheric Mercury

PubMed Central

Cheng, I.; Zhang, L.; Xu, X.

2016-01-01

Gaseous oxidized mercury (GOM) and particle-bound mercury (PBM) measurement uncertainties could potentially affect the analysis and modeling of atmospheric mercury. This study investigated the impact of GOM measurement uncertainties on Principal Components Analysis (PCA), Absolute Principal Component Scores (APCS), and Concentration-Weighted Trajectory (CWT) receptor modeling results. The atmospheric mercury data input into these receptor models were modified by combining GOM and PBM into a single reactive mercury (RM) parameter and excluding low GOM measurements to improve the data quality. PCA and APCS results derived from RM or excluding low GOM measurements were similar to those in previous studies, except for a non-unique component and an additional component extracted from the RM dataset. The percent variance explained by the major components from a previous study differed slightly compared to RM and excluding low GOM measurements. CWT results were more sensitive to the input of RM than GOM excluding low measurements. Larger discrepancies were found between RM and GOM source regions than those between RM and PBM. Depending on the season, CWT source regions of RM differed by 40–61% compared to GOM from a previous study. No improvement in correlations between CWT results and anthropogenic mercury emissions were found. PMID:26857835

The impact of aerosol composition on the particle to gas partitioning of reactive mercury.

PubMed

Rutter, Andrew P; Schauer, James J

2007-06-01

A laboratory system was developed to study the gas-particle partitioning of reactive mercury (RM) as a function of aerosol composition in synthetic atmospheric particulate matter. The collection of RM was achieved by filter- and sorbent-based methods. Analyses of the RM collected on the filters and sorbents were performed using thermal extraction combined with cold vapor atomic fluorescence spectroscopy (CVAFS), allowing direct measurement of the RM load on the substrates. Laboratory measurements of the gas-particle partitioning coefficients of RM to atmospheric aerosol particles revealed a strong dependence on aerosol composition, with partitioning coefficients that varied by orders of magnitude depending on the composition of the particles. Particles of sodium nitrate and the chlorides of potassium and sodium had high partitioning coefficients, shifting the RM partitioning toward the particle phase, while ammonium sulfate, levoglucosan, and adipic acid caused the RM to partition toward the gas phase and, therefore, had partitioning coefficients that were lower by orders of magnitude.

sin 2 θ eff lept and M W(indirect) extracted from 9 fb -1 μ +μ - event sample at CDF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bodek, A.

2016-05-31

Here, we report on the extraction ofmore » $$\\sin^2\\theta^{\\rm lept}_{\\rm eff}$$ and indirect measurement of the mass of the W boson from the forward-backward asymmetry of $$\\mu^+\\mu^-$$ events in the $Z$ boson mass region. The data sample collected by the CDF detector corresponds to the full 9 fb$$^{-1}$$ run II sample. We measure $$\\sin^2 \\theta^{\\rm lept}_{\\rm eff} = 0.2315 \\pm 0.0010$$, $$ \\sin^2 \\theta_W = 0.2233 \\pm 0.0009$$ and $$M_W ({\\rm indirect}) = 80.365 \\pm 0.047 \\;{\\rm GeV}/c^2$$, where each uncertainty includes both statistical and systematic contributions. Comparison with the results of the D0 collaboration are presented.« less

A Infrared Absorption Study of Dopant-Hydrogen Complexes in Semiconductors

NASA Astrophysics Data System (ADS)

Kozuch, David Michael

1992-01-01

Hydrogen passivation of shallow electrical dopants in semiconductors has been investigated. In particular, the passivation of the shallow dopants tin, carbon, and silicon in gallium arsenide has been studied via Fourier transform infrared spectroscopy, thermal annealing, Hall effect, secondary ion mass spectroscopy, and uniaxial stress. The bond-stretching and bond-wagging vibrational modes of the rm Sn_{Ga} - H complex in GaAs have been identified at 1327.8 cm^{-1} and 967.7 cm ^{-1}, respectively. The presence of hydrogen in the defect pair is confirmed by the deuterium -shifted bond-stretching signal at 746.6 cm^ {-1}. Infrared and Hall data correlated the passivation of Sn_{rm Ga } donors with the formation of the rm Sn_{Ga} - H complexes. A series of isochronal anneals probed the thermal stability of the complex. Arguments supporting an antibonding configuration for the rm Sn_{Ga} - H complex are presented. Infrared measurements on highly carbon doped epi -layers reveal new absorption signals at 2643, 2651, and 2688 cm^{-1} in addition to the previously identified rm C_ {As} - H stretching vibration at 2636 cm^{-1}. These new signals are related to a family of carbon-hydrogen complexes: rm C_{x} - H. Deuterium -shifted counterparts for all these signals have been observed for the first time. Sources of hydrogen have been traced to the metalorganic precursors and carrier gas used during epi-layer growth. Hydrogen-containing annealing ambients were surprisingly effective for introducing hydrogen into the epi-layers. Several atomic arrangements for the new rm C_{x} - H complexes have been considered with the most likely candidate being a rm C_{As} - H complex perturbed by another C_{rm As} acceptor in a second nearest neighbor position. The first uniaxial stress measurements have been performed on the rm Si_{As} - H complex in GaAs. The stress-induced frequency shifts and the intensity ratios of the stress-split components of the 2094.45 cm^{-1} stretching frequency reveal that the complex has trigonal symmetry. Reorientation of the stress-aligned complexes occurred by thermally activated jumps of the hydrogen atom with an activation energy of E_{rm A} = 0.26 eV. The piezospectroscopic tensor of the rm Si_{As} - H complex has been determined. The similarities between the stress data for the rm Si_{As } - H complex and the well-studied B - H complex in silicon suggest a bond-centered configuration for the rm Si_{As} - H defect pair.

75 FR 70618 - Distribution of Source Material to Exempt Persons and to General Licensees and Revision of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-18

... the public sufficient time to review and comment on the proposed rule with the benefit of review of... at the NRC's Electronic Reading Room at http://www.nrc.gov/reading-rm/adams.html . From this page... comment on the proposed rule with the benefit of review of the draft implementation guidance, the NRC has...

Acceptance of Safety and Mission Success Risks

NASA Technical Reports Server (NTRS)

Groen, Frank

2015-01-01

NASA has developed an objectives based hierarchy for guiding Reliability and Maintainability (RM) activities. This presentation overviews the hierarchy and proposes to the international trilateral partners to formulate a task force to consider the elements of the NASA RM framework, as captured in the hierarchy of RM considerations, to identify commonalities and differences in the way RM is addressed by the flight projects among the partners.

Complete genomic sequences of Campylobacter jejuni strains RM3196 (233.94) and RM3197 (308.95) that were isolated from patients with Guillain-Barré Syndrome

USDA-ARS?s Scientific Manuscript database

An infection with Campylobacter jejuni subsp. jejuni (Cjj) is a leading cause of foodborne gastroenteritis in humans and also the most prevalent infection preceding Guillain-Barré syndrome (GBS). This study describes the complete genomic sequences of Cjj HS:41 strains RM3196 (233.94) and RM3197 (308...

Test-Retest Reliability of Rating of Perceived Exertion and Agreement With 1-Repetition Maximum in Adults.

PubMed

Bove, Allyn M; Lynch, Andrew D; DePaul, Samantha M; Terhorst, Lauren; Irrgang, James J; Fitzgerald, G Kelley

2016-09-01

Study Design Clinical measurement. Background It has been suggested that rating of perceived exertion (RPE) may be a useful alternative to 1-repetition maximum (1RM) to determine proper resistance exercise dosage. However, the test-retest reliability of RPE for resistance exercise has not been determined. Additionally, prior research regarding the relationship between 1RM and RPE is conflicting. Objectives The purpose of this study was to (1) determine test-retest reliability of RPE related to resistance exercise and (2) assess agreement between percentages of 1RM and RPE during quadriceps resistance exercise. Methods A sample of participants with and without knee pathology completed a series of knee extension exercises and rated the perceived difficulty of each exercise on a 0-to-10 RPE scale, then repeated the procedure 1 to 2 weeks later for test-retest reliability. To determine agreement between RPE and 1RM, participants completed knee extension exercises at various percentages of their 1RM (10% to 130% of predicted 1RM) and rated the perceived difficulty of each exercise on a 0-to-10 RPE scale. Percent agreement was calculated between the 1RM and RPE at each resistance interval. Results The intraclass correlation coefficient indicated excellent test-retest reliability of RPE for quadriceps resistance exercises (intraclass correlation coefficient = 0.895; 95% confidence interval: 0.866, 0.918). Overall percent agreement between RPE and 1RM was 60%, but agreement was poor within the ranges that would typically be used for training (50% 1RM for muscle endurance, 70% 1RM and greater for strength). Conclusion Test-retest reliability of perceived exertion during quadriceps resistance exercise was excellent. However, agreement between the RPE and 1RM was poor, especially in common training zones for knee extensor strengthening. J Orthop Sports Phys Ther 2016;46(9):768-774. Epub 5 Aug 2016. doi:10.2519/jospt.2016.6498.

Analysis of factors that influence the maximum number of repetitions in two upper-body resistance exercises: curl biceps and bench press.

PubMed

Iglesias, Eliseo; Boullosa, Daniel A; Dopico, Xurxo; Carballeira, Eduardo

2010-06-01

The purpose of this study was to analyze the influence of exercise type, set configuration, and relative intensity load on relationship between 1 repetition maximum (1RM) and maximum number of repetitions (MNR). Thirteen male subjects, experienced in resistance training, were tested in bench press and biceps curl for 1RM, MNR at 90% of 1RM with cluster set configuration (rest of 30s between repetitions) and MNR at 70% of 1RM with traditional set configuration (no rest between repetitions). A lineal encoder was used for measuring displacement of load. Analysis of variance analysis revealed a significant effect of load (p<0.01) and a tendency in exercise factor (p=0.096), whereas the interaction effect was not significant. MNR at 70% of 1RM was lower for biceps curl (16.31+/-2.59 vs. 8.77+/-3 in bench press and biceps curl, respectively; p<0.05) and at 90% of 1RM (21.85+/-11.06 vs. 18.54+/-12.84 in bench press and biceps curl, respectively; p>0.05). Correlation between 1RM and MNR was significant for medium-intensity in biceps curl (r=-0.574; p<0.05) and between MNR and 1RM/body mass (r=-0.574; p<0.05). Neither 1RM nor 1RM/body mass correlated with velocity along set, so velocity seems to be similar at a same relative intensity for subjects with differences in maximum strength levels. From our results, we suggest the employment of MNR rather than % of 1RM for training monitoring. Furthermore, we suggest the introduction of cluster set configuration for upper-body assessment of MNR and for upper-body muscular endurance training at high-intensity loads, as it seems an efficient approach in looking for sessions with greater training volumes. This could be an interesting approach for such sports as wrestling or weightlifting.

The Relationship Between Level of Adherence to Automatic Wireless Remote Monitoring and Survival in Pacemaker and Defibrillator Patients.

PubMed

Varma, Niraj; Piccini, Jonathan P; Snell, Jeffery; Fischer, Avi; Dalal, Nirav; Mittal, Suneet

2015-06-23

Remote monitoring (RM) technology embedded within cardiac rhythm devices permits continuous monitoring, which may result in improved patient outcomes. This study used "big data" to assess whether RM is associated with improved survival and whether this is influenced by the type of cardiac device and/or its degree of use. We studied 269,471 consecutive U.S. patients implanted between 2008 and 2011 with pacemakers (PMs), implantable cardioverter-defibrillators (ICDs), or cardiac resynchronization therapy (CRT) with pacing capability (CRT-P)/defibrillation capability (CRT-D) with wireless RM. We analyzed weekly use and all-cause survival for each device type by the percentage of time in RM (%TRM) stratified by age. Socioeconomic influences on %TRM were assessed using 8 census variables from 2012. The group had implanted PMs (n = 115,076; 43%), ICDs (n = 85,014; 32%), CRT-D (n = 61,475; 23%), and CRT-P (n = 7,906; 3%). When considered together, 127,706 patients (47%) used RM, of whom 67,920 (53%) had ≥75%TRM (high %TRM) and 59,786 (47%) <75%TRM (low %TRM); 141,765 (53%) never used RM (RM None). RM use was not affected by age or sex, but demonstrated wide geographic and socioeconomic variability. Survival was better in high %TRM versus RM None (hazard ratio [HR]: 2.10; p < 0.001), in high %TRM versus low %TRM (HR: 1.32; p < 0.001), and also in low %TRM versus RM None (HR: 1.58; p < 0.001). The same relationship was observed when assessed by individual device type. RM is associated with improved survival, irrespective of device type (including PMs), but demonstrates a graded relationship with the level of adherence. The results support the increased application of RM to improve patient outcomes. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Improved survival in patients enrolled promptly into remote monitoring following cardiac implantable electronic device implantation.

PubMed

Mittal, Suneet; Piccini, Jonathan P; Snell, Jeff; Prillinger, Julie B; Dalal, Nirav; Varma, Niraj

2016-08-01

Guidelines advocate remote monitoring (RM) in patients with a cardiac implantable electronic device (CIED). However, it is not known when RM should be initiated. We hypothesized that prompt initiation of RM (within 91 days of implant) is associated with improved survival compared to delayed initiation. This retrospective, national, observational cohort study evaluated patients receiving new implants of market-released St. Jude Medical™ pacemakers (PM), implantable cardioverter defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices. Patients were assigned to one of two groups: an "RM Prompt" group, in which RM was initiated within 91 days of implant; and an "RM Delayed" group, in which RM was initiated >91 days but ≤365 days of implant. The primary endpoint was all-cause mortality. The cohort included 106,027 patients followed for a mean of 2.6 ± 0.9 years. Overall, 47,014 (44 %) patients had a PM, 31,889 (30 %) patients had an ICD, 24,005 (23 %) patients had a CRT-D, and 3119 (3 %) patients had a CRT-P. Remote monitoring was initiated promptly (median 4 weeks [IQR 2, 8 weeks]) in 66,070 (62 %) patients; in the other 39,957 (38 %) patients, RM initiation was delayed (median 24 weeks [IQR 18, 34 weeks]). In comparison to delayed initiation, prompt initiation of RM was associated with a lower mortality rate (4023 vs. 4679 per 100,000 patient-years, p < 0.001) and greater adjusted survival (HR 1.18 [95 % CI 1.13-1.22], p < 0.001). Our data, for the first time, show improved survival in patients enrolled promptly into RM following CIED implantation. This advantage was observed across all CIED device types.

The Association between Maximal Bench Press Strength and Isometric Handgrip Strength among Breast Cancer Survivors

PubMed Central

Rogers, Benjamin H.; Brown, Justin C.; Gater, David R.; Schmitz, Kathryn H.

2016-01-01

Objective One-repetition maximum (1-RM) bench press strength is considered the gold standard to quantify upper-body muscular strength. Isometric handgrip strength is frequently used as a surrogate for 1-RM bench press strength among breast cancer (BrCa) survivors. The relationship between 1-RM bench press strength and isometric handgrip strength, however, has not been characterized among BrCa survivors. Design Cross-sectional study. Setting Laboratory. Participants Community-dwelling BrCa survivors. Interventions Not applicable. Main Outcome Measure 1-RM bench press strength was measured with a barbell and exercise bench. Isometric handgrip strength was measured using an isometric dynamometer with three maximal contractions of left and right hands. All measures were conducted by staff with training in clinical exercise testing. Results Among 295 BrCa survivors, 1-RM bench press strength was 18.2±6.1 kg (range: 2.2-43.0) and isometric handgrip strength was 23.5±5.8 kg (range: 9.0-43.0). The strongest correlate of 1-RM bench press strength was the average isometric handgrip strength of both hands (r=0.399; P<0.0001). Mean-difference analysis suggested that the average isometric handgrip strength of both hands overestimated 1-RM bench press strength by 4.7 kg (95% limits of agreement: −8.2 to 17.6). In a multivariable linear regression model, the average isometric handgrip strength of both hands (β=0.31; P<0.0001) and age (β=−0.20; P<0.0001) were positively correlated with 1-RM bench press strength (R2=0.23). Conclusions Isometric handgrip strength is a poor surrogate for 1-RM bench press strength among BrCa survivors. 1-RM bench press and isometric handgrip strength quantify distinct components of muscular strength. PMID:27543047

Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats.

PubMed

Fidan, Emin; Foley, Lesley M; New, Lee Ann; Alexander, Henry; Kochanek, Patrick M; Hitchens, T Kevin; Bayır, Hülya

2018-01-01

Mild traumatic brain injury (mTBI) in children is a common and serious public health problem. Traditional neuroimaging findings in children who sustain mTBI are often normal, putting them at risk for repeated mTBI (rmTBI). There is a need for more sensitive imaging techniques capable of detecting subtle neurophysiological alterations after injury. We examined neurochemical and white matter changes using diffusion tensor imaging of the whole brain and proton magnetic resonance spectroscopy of the hippocampi at 7 Tesla in 18-day-old male rats at 7 days after mTBI and rmTBI. Traumatic axonal injury was assessed by beta-amyloid precursor protein accumulation using immunohistochemistry. A significant decrease in fractional anisotropy and increase in axial and radial diffusivity were observed in several brain regions, especially in white matter regions, after a single mTBI versus sham and more prominently after rmTBI. In addition, we observed accumulation of beta-amyloid precursor protein in the external capsule after mTBI and rmTBI. mTBI and rmTBI reduced the N-acetylaspartate/creatine ratio (NAA/Cr) and increased the myoinositol/creatine ratio (Ins/Cr) versus sham. rmTBI exacerbated the reduction in NAA/Cr versus mTBI. The choline/creatine (Cho/Cr) and (lipid/Macro Molecule 1)/creatine (Lip/Cr) ratios were also decreased after rmTBI versus sham. Diffusion tensor imaging findings along with the decrease in Cho and Lip after rmTBI may reflect damage to axonal membrane. NAA and Ins are altered at 7 days after mTBI and rmTBI likely reflecting neuro-axonal damage and glial response, respectively. These findings may be relevant to understanding the extent of disability following mTBI and rmTBI in the immature brain and may identify possible therapeutic targets.

The Cost and Utility of Renal Transplantation in Malaysia

PubMed Central

Bavanandan, Sunita; Yap, Yok-Chin; Ahmad, Ghazali; Wong, Hin-Seng; Azmi, Soraya; Goh, Adrian

2015-01-01

Background Kidney transplantation is the optimal therapy for the majority of patients with end-stage renal disease. However, the cost and health outcomes of transplantation have not been assessed in a middle-income nation with a low volume of transplantation, such as Malaysia. Aim and Methods This study used microcosting methods to determine the cost and health outcomes of living and deceased donor kidney transplantation in adult and pediatric recipients. The perspective used was from the Ministry of Health Malaysia. Cost-effectiveness measures were cost per life year (LY) and cost per quality-adjusted LYs. The time horizon was the lifetime of the transplant recipient from transplant to death. Results Records of 206 KT recipients (118 adults and 88 children) were obtained for microcosting. In adults, discounted cost per LY was US $8609(Malaysian Ringgit [RM]29 482) and US $13 209(RM45 234) for living-donor kidney transplant (LKT) and deceased donor kidney transplant (DKT), respectively, whereas in children, it was US $10 485(RM35 905) and US $14 985(RM51 317), respectively. Cost per quality-adjusted LY in adults was US $8826 (RM30 224) for LKT and US $13 592(RM46 546) for DKT. Total lifetime discounted costs of adult transplants were US $119 702 (RM409 921) for LKT, US $147 152 (RM503 922) for DKT. Total costs for pediatric transplants were US $154 841(RM530 252) and US $159 313(RM545 566) for the 2 categories respectively. Conclusions Both LKT and DKT are economically favorable for Malaysian adult and pediatric patients with ESRD and result in improvement in quality of life. PMID:27500211

Spontaneous abortion and recurrent miscarriage: A comparison of cytogenetic diagnosis in 250 cases.

PubMed

Choi, Tae Yeong; Lee, Hye Min; Park, Won Kyoung; Jeong, So Yeong; Moon, Hwa Sook

2014-11-01

The purpose of this study was to determine the frequency and distribution of cytogenetically abnormal miscarriages in couples with spontaneous abortions (SA) or recurrent miscarriages (RM). Karyotyping of specimens from 164 abortuses with SA and 86 abortuses with RM was successfully performed according to the standard cytogenetic methods using G-banding technique. Among the total 164 cases of SA group, 81 (49.4%) were euploid and the rest (83, 50.6%) showed chromosomal abnormalities. In RM(≥2) and RM(≥3) group, 31 (36.0%)/27 (34.6%) cases were euploid and 55 (64.0%)/51(65.4%) cases were abnormal, respectively. A statistically significant difference was found in the rate of cytogenetic abnormality between SA and RM groups (P<0.05). In all groups, women with advanced maternal age (≥35 years) had a higher rate of chromosome anomalies compared with women younger than age 35 (normal:abnormal = 32.4%:67.6% for ≥35 years and 53.8%:46.2% for <35 years in SA; 19.2%:80.8%/21.7%:78.3% for ≥35 years and 43.3%:56.7%/40.0%:60.0% for <35 years in RM(≥2) and RM(≥3), respectively; P<0.05). In SA group, an increase of normal karyotypes was noted with increased gestational age (<10 week, 38.0%; 10-15 week, 53.5%; 16-20 week, 65.7%). In RM group, most of cases were in <10 week and the frequency of trisomies with chromosomes 1 to 10 were increased compared with that of SA. There was a statistically significant difference in the frequency and distribution of chromosomal abnormalities between SA and RM groups. Our results will provide useful information for diagnosis and genetic counseling of patients with SA or RM.

Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133.

PubMed

Perreault, Martin; Maltais, René; Dutour, Raphaël; Poirier, Donald

2016-11-01

RM-133 is a key representative of a new family of aminosteroids reported as potent anticancer agents. Although RM-133 produced interesting results in 4 mouse xenograft cancer models when injected subcutaneously, it needs to be improved to increase its in vivo potency. Thus, to obtain an analog of RM-133 with a better drug potential, a structure-activity relationship study was conducted by synthesizing eleven RM-133-related compounds and addressing their antiproliferative activity on 3 human cancer cells (HL-60, OVCAR-3 and PANC-1) and 3 human normal cell lines (primary ovary, pancreas and renal proximal tubule) as well as their metabolic stability in human liver microsomes. When the 2β-tertiary amine of RM-133 was transformed into a salt or moved to position 3β, the anticancer activity was lost. Modifying the orientation of the side chain of RM-133 increased anticancer activity and selectivity, but led to a drastic loss of stability. The protection of the 3α-hydroxyl of RM-133 by the formation of an ester or a carbamate stabilized the molecule against the phase I metabolic enzymes without affecting its anticancer activity. In comparison to RM-133, the 3-dimethylcarbamate derivative 3 is more selective for cancer cells over normal cells and is much more stable in liver microsomes. Those results support the use of a pro-drug strategy targeting the 3α-hydroxyl of RM-133 as an approach to improve its drug properties. The work presented will enable the development of an optimized anticancer drug of the aminosteroid family that is suitable for a future phase I clinical trial. Copyright © 2016 Elsevier Inc. All rights reserved.

An examination of the predictive validity of the risk matrix 2000 in England and wales.

PubMed

Barnett, Georgia D; Wakeling, Helen C; Howard, Philip D

2010-12-01

This study examined the predictive validity of an actuarial risk-assessment tool with convicted sexual offenders in England and Wales. A modified version of the RM2000/s scale and the RM2000 v and c scales (Thornton et al., 2003) were examined for accuracy in predicting proven sexual violent, nonsexual violent, and combined sexual and/or nonsexual violent reoffending in a sample of sexual offenders who had either started a community sentence or been released from prison into the community by March 2007. Rates of proven reoffending were examined at 2 years for the majority of the sample (n = 4,946), and 4 years ( n = 578) for those for whom these data were available. The predictive validity of the RM2000 scales was also explored for different subgroups of sexual offenders to assess the robustness of the tool. Both the modified RM2000/s and the complete v and c scales effectively classified offenders into distinct risk categories that differed significantly in rates of proven sexual and/or nonsexual violent reoffending. Survival analyses on the RM2000/s and v scales (N = 9,284) indicated that the higher risk groups offended more quickly and at a higher rate than lower risk groups. The relative predictive validity of the RM2000/s, v, and c, as calculated using Receiver Operating Characteristics (ROC) analyses, were moderate (.68) for RM2000/s and large for both the RM2000/c (.73) and RM2000/v (.80), at the 2-year follow-up. RM2000/s was moderately accurate in predicting relative risk of proven sexual reoffending for a variety of subgroups of sexual offenders.

Genetic evaluation of recombinant inbred lines of rice (Oryza sativa L.) for grain zinc concentrations, yield related traits and identification of associated SSR markers.

PubMed

Bekele, Berhanu D; Naveen, G K; Rakhi, S; Shashidhar, H E

2013-12-01

The objectives of the present study were to evaluate genetic variability parameters, correlations that exist for grain Zn concentration and yield related traits and identification of SSR markers linked to these traits in rice. One hundred seventy six Recombinant Inbred Lines (RILs) of Azucena X Moromutant were grown at University of Agricultural Sciences, Bangalore in augmented experimental design during wet seasons of 2010 and 2011. The study revealed significant genetic variability for all the traits. Grain yield per plant and grain zinc concentration showed higher phenotypic and genotypic co-efficient of variation. Significant positive correlation was observed for grain yield per plant with number of productive tillers per plant (r = 0.5) and number of tillers per plant (r = 0.4). Grain zinc concentration showed negative correlation with grain yield per plant (r = - 0.27). The path-coefficient analysis indicated the positive direct effect of number of productive tillers per plant on grain yield per plant (0.514). Grain zinc concentration showed negative direct effect on grain yield per plant (-0.186). Single-marker analysis using 26 SSR markers on RILs mapping population showed that RM212, RM263, RM6832, RM152, RM21, RM234 and RM3331 had association with grain zinc concentration and other yield related traits. But validation of these markers on fifty two rice genotypes showed that only three markers RM263, RM152 and RM21 had association with grain zinc concentration. Therefore, the genetic information generated and molecular markers identified from this study could be used for zinc biofortification programmes in rice.

Corrosion science, corrosion engineering, and advanced technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Latanision, R.M.

1995-04-01

Professor R.M. Latanision was the 1994 recipient of the Willis Rodney Whitney Award sponsored by NACE International. The present work is taken from his award lecture at CORROSION/94 held in March 1994 in Baltimore, MD. Latanision discussed the interplay between corrosion science and corrosion engineering in advancing technology. His lecture focused on supercritical water oxidation and other technologies that have been under study in the H.H. Uhlig Corrosion Laboratory and in which the chemical properties of new materials and traditional materials have proven integral to the development of contemporary or advanced engineering systems.

Unclassified Publications of Lincoln Laboratory. Volume 8

DTIC Science & Technology

1981-12-15

F.J. Leonberger 5076 Formation of the XeBr Exciplex D.J. Ehrlich J. Chem. Phys. 73, 3038 by Xe-Br 2(D’) Collisions R.M. Osgood, Jr. (1980), DTIC AD-AI0...Processing of Materials, plantation and Laser J.P. Donnelly C.W. White and P.S. Peercy, Annealing D.E. Mull Eds. (Academic Press, New R. Bradbury York, 1980...Materials, Amorphous Ge Films: The R.P. Gale C.W. White and P.S. Peercy. Role of Latent Heat in Crystal- R.L. Chapman Eds. (Academic Press, New

Visible Light Emitting Materials and Injection Devices

DTIC Science & Technology

1993-01-01

view to preventing the occurrence of faceting in these films. (II) MOCVD growth of II-VI materials (Tim Anderson) (11.1) Growth of novel Zn ZCd SSeI ...E.J. Stofko and R.J, Paff, "Synthesis and some properties of BeTe, BeSe, and BeS", J, Phys, Chem. Soiid. 33 (1972) 501. 2. R. Yamamoto, M . Inoue, K...Technology," SID Seminar Lecture Notes, 1988, Vol. 1 7. R.M. Park, M ,B. Troffer, and C.M. Rouleau, "p-type ZnSe by nitrogen atom beam doping during molecular

Effects of Badminton Expertise on Representational Momentum: A Combination of Cross-Sectional and Longitudinal Studies

PubMed Central

Jin, Hua; Wang, Pin; Fang, Zhuo; Di, Xin; Ye, Zhuo’er; Xu, Guiping; Lin, Huiyan; Cheng, Yongmin; Li, Yongjie; Xu, Yong; Rao, Hengyi

2017-01-01

Representational momentum (RM) has been found to be magnified in experts (e.g., sport players) with respect to both real and implied motion in expert-familiar domains. However, it remains unclear whether similar effects can be achieved in expert-unfamiliar domains, especially within the context of implied motion. To answer this question, we conducted two independent experiments using an implied motion paradigm and examined the expert effects of badminton training on RM in both adult and child players. In Experiment 1, we used a cross-sectional design and compared RM between adult professional badminton players and matched controls. The results revealed significantly enhanced RM for adult players, supporting the expert effect in expert-unfamiliar domains for implied motion. However, cross-sectional studies could not ascertain whether the observed expert effect was due to innate factors or expertise acquirement. Therefore, in Experiment 2, we used a longitudinal design and compared RM between two groups of child participants, naming child players who had enrolled professional badminton training program at a sports school and age-matched peer non-players who attended an ordinary primary school without sports training. Before training, there were no differences in RM among child players, their non-player peers, and adult non-players. However, after 4 years of badminton training, child players demonstrated significantly enhanced RM compared to themselves prior to training. The increased RM observed in both adult and child players suggests that badminton expertise modulates implied motion RM. PMID:28970810

Predicting the Size and Timing of Sunspot Maximum for Cycle 24

NASA Technical Reports Server (NTRS)

Wilson, Robert M.

2010-01-01

For cycle 24, the minimum value of the 12-month moving average (12-mma) of the AA-geomagnetic index in the vicinity of sunspot minimum (AAm) appears to have occurred in September 2009, measuring about 8.4 nT and following sunspot minimum by 9 months. This is the lowest value of AAm ever recorded, falling below that of 8.9 nT, previously attributed to cycle 14, which also is the smallest maximum amplitude (RM) cycle of the modern era (RM = 64.2). Based on the method of Ohl (the preferential association between RM and AAm for an ongoing cycle), one expects cycle 24 to have RM = 55+/-17 (the +/-1 - sigma prediction interval). Instead, using a variation of Ohl's method, one based on using 2-cycle moving averages (2-cma), one expects cycle 23's 2-cma of RM to be about 115.5+/-8.7 (the +/-1 - sigma prediction interval), inferring an RM of about 62+/-35 for cycle 24. Hence, it seems clear that cycle 24 will be smaller in size than was seen in cycle 23 (RM = 120.8) and, likely, will be comparable in size to that of cycle 14. From the Waldmeier effect (the preferential association between the ascent duration (ASC) and RM for an ongoing cycle), one expects cycle 24 to be a slow-rising cycle (ASC > or equal to 48 months), having RM occurrence after December 2012, unless it turns out to be a statistical outlier.

Bench press and push-up at comparable levels of muscle activity results in similar strength gains.

PubMed

Calatayud, Joaquin; Borreani, Sebastien; Colado, Juan C; Martin, Fernando; Tella, Victor; Andersen, Lars L

2015-01-01

Electromyography (EMG) exercise evaluation is commonly used to measure the intensity of muscle contraction. Although researchers assume that biomechanically comparable resistance exercises with similar high EMG levels will produce similar strength gains over the long term, no studies have actually corroborated this hypothesis. This study evaluated EMG levels during 6 repetition maximum (6RM) bench press and push-up, and subsequently performed a 5-week training period where subjects were randomly divided into 3 groups (i.e., 6RM bench press group, 6RM elastic band push-up group, or control group) to evaluate muscle strength gains. Thirty university students with advanced resistance training experience participated in the 2-part study. During the training period, exercises were performed using the same loads and variables that were used during the EMG data collection. At baseline, EMG amplitude showed no significant difference between 6RM bench press and band push-up. Significant differences among the groups were found for percent change (Δ) between pretest and posttest for 6RM (p = 0.017) and for 1 repetition maximum (1RM) (p < 0.001). Six repetition maximum bench press group and 6RM elastic band push-up group improved their 1RM and 6RM (Δ ranging from 13.65 to 22.21) tests significantly with similar gains, whereas control group remains unchanged. Thus, when the EMG values are comparable and the same conditions are reproduced, the aforementioned exercises can provide similar muscle strength gains.

The Effects of Mental Imagery with Video-Modeling on Self-Efficacy and Maximal Front Squat Ability

PubMed Central

Buck, Daniel J. M.; Hutchinson, Jasmin C.; Winter, Christa R.; Thompson, Brian A.

2016-01-01

This study was designed to assess the effectiveness of mental imagery supplemented with video-modeling on self-efficacy and front squat strength (three repetition maximum; 3RM). Subjects (13 male, 7 female) who had at least 6 months of front squat experience were assigned to either an experimental (n = 10) or a control (n = 10) group. Subjects′ 3RM and self-efficacy for the 3RM were measured at baseline. Following this, subjects in the experimental group followed a structured imagery protocol, incorporating video recordings of both their own 3RM performance and a model lifter with excellent technique, twice a day for three days. Subjects in the control group spent the same amount of time viewing a placebo video. Following three days with no physical training, measurements of front squat 3RM and self-efficacy for the 3RM were repeated. Subjects in the experimental group increased in self-efficacy following the intervention, and showed greater 3RM improvement than those in the control group. Self-efficacy was found to significantly mediate the relationship between imagery and front squat 3RM. These findings point to the importance of mental skills training for the enhancement of self-efficacy and front squat performance.

Increased frequency of rhinitis medicamentosa due to media advertising for nasal topical decongestants.

PubMed

Archontaki, M; Symvoulakis, E K; Hajiioannou, J K; Stamou, A K; Kastrinakis, S; Bizaki, A J; Kyrmizakis, D E

2009-01-01

The aim of this study was to investigate the frequency of rhinitis medicamentosa (RM) in patients attending the ENT outpatient clinic of the General Hospital of Rethymnon (Crete, Greece) before and after the launch of an intensive nasal decongestant advertising campaign in Greece. We reviewed the medical records of the patients with RM seen at the ENT outpatient clinic in May, June and July of 2003 and 2006. We analyzed and recorded the gender, age, and related clinical information of the patients with RM. In May, June and July of 2003, 41 patients out of a total of 1780 patients attending the ENT outpatient clinic were diagnosed with RM (2.3%). In the same months in 2006, 161 patients out a total of 1898 patients were diagnosed with RM (8.5%). The frequency of RM in these groups was therefore found to have increased significantly between 2003 and 2006. In 2006, 8 out of 10 patients with RM reported that they had made their purchasing decision solely on the basis of the information supplied by the drug advertisement without consulting their doctor or pharmacist. We suggest that the intensive media advertising campaign for nasal topical decongestants (particularly on TV) which started in 2004 is probably the main reason for this "endemic" RM.

Ground reaction forces and knee kinetics during single and repeated badminton lunges.

PubMed

Lam, Wing Kai; Ding, Rui; Qu, Yi

2017-03-01

Repeated movement (RM) lunge that frequently executed in badminton might be used for footwear evaluation. This study examined the influence of single movement (SM) and RM lunges on the ground reaction forces (GRFs) and knee kinetics during the braking phase of a badminton lunge step. Thirteen male university badminton players performed left-forward lunges in both SM and RM sessions. Force platform and motion capturing system were used to measure GRFs and knee kinetics variables. Paired t-test was performed to determine any significant differences between SM and RM lunges regarding mean and coefficient of variation (CV) in each variable. The kinetics results indicated that compared to SM lunges, the RM lunges had shorter contact time and generated smaller maximum loading rate of impact force, peak knee anterior-posterior force, and peak knee sagittal moment but generated larger peak horizontal resultant forces (Ps < 0.05). Additionally, the RM lunges had lower CV for peak knee medial-lateral and vertical forces (Ps < 0.05). These results suggested that the RM testing protocols had a distinct loading response and adaptation pattern during lunge and that the RM protocol showed higher within-trial reliability, which may be beneficial for the knee joint loading evaluation under different interventions.

Increasing arsenic sorption on red mud by phosphogypsum addition.

PubMed

Lopes, G; Guilherme, L R G; Costa, E T S; Curi, N; Penha, H G V

2013-11-15

Mining by-products have been tested as adsorbents for arsenic in order to reduce As bioavailability. This study evaluated a red mud (RM) treated with or without phosphogypsum (G) in order to improve its As retention. Red mud and G samples and their mixtures were chemically and mineralogically characterized to gather information concerning their composition, which is key for a better understanding of the adsorbent properties. Phosphogypsum was added to RM in the following proportions: 0, 1, 2, 5, 10, and 25% by weight. These mixtures were subjected to As adsorption and desorption and tested for their maximum adsorption capacity of As (AsMAC). Arsenic adsorption increased upon increasing the proportion of G added to RM. The AsMAC at pure RM reached 909 mg kg(-1), whereas the 75%-RM+25%-G mixture sorbed up to 3333 mg kg(-1) of As, i.e., a 3.5-fold increase in AsMAC. Using G in mixtures with RM increases the efficiency of As adsorption due to the presence of Ca(2+), which alters the charge balance of the adsorbent, leading to the formation of ternary complexes. Addition of G to RM is thus a promising technique to improve As retention, while providing additional value to both by-products, G and RM. Copyright © 2012 Elsevier B.V. All rights reserved.

Correlation between Resection Margin and Disease Recurrence with a Restricted Cubic Spline Model in Patients with Resected Hepatocellular Carcinoma.

PubMed

Lee, Woohyung; Han, Ho-Seong; Ahn, Soyeon; Yoon, Yoo-Seok; Cho, Jai Young; Choi, YoungRok

2018-01-17

The relationship between resection margin (RM) and recurrence of resected hepatocellular carcinoma (HCC) is unclear. We reviewed clinical data for 419 patients with HCC. The oncologic outcomes were compared between 2 groups of patients classified according to the inflexion point of the restricted cubic spline plot. The patients were divided according to an RM of <1 cm (n = 233; narrow RM group) or ≥1 cm (n = 186; wide RM group). The 5-year recurrence-free survival (RFS) rate was lower (34.8 vs. 43.8%, p = 0.042) and recurrence near the resection site was more frequent (4.7 vs. 0%, p = 0.010) in the narrow RM group. Patients with multiple lesions, or prior transarterial chemoembolization (TACE) or radiofrequency ablation (RFA) were excluded from subgroup analyses. In patients with a 2-5 cm HCC, the 5-year RFS was greater in the wide RM group (54.4 vs. 32.5%, p = 0.036). Narrow RM (hazard ratio 1.750, 95% CI 1.029-2.976, p = 0.039) was independently associated with disease recurrence. In patients with a single 2-5 cm HCC without prior TACE/RFA, an RM of ≥1 cm was associated with lower risk of recurrence after liver resection. © 2018 S. Karger AG, Basel.

Potential Renoprotective Effects of Rosemary and Thyme Against Gentamicin Toxicity in Rats.

PubMed

Abdel-Azeem, Amal S; Hegazy, Amany M; Zeidan, Hala M; Ibrahim, Khadiga S; El-Sayed, Eman M

2017-07-04

Gentamicin (GM) is a drug used commonly against gram-negative bacteria. Its therapeutic use is mainly limited by its nephrotoxicity. This investigation was aimed at evaluating the nephroprotective effects of rosemary (RM; Rosmarinus officinalis) and thyme (TV; Thymus vulgaris) against GM toxicity. Rats were divided into four groups. Normal control group was treated intraperitoneally (i.p.) with saline; positive control group was administered GM 60 mg/kg/day i.p.; RM group was co-administered 8% RM aqueous extract, 10 mL/kg/day, orally with GM; and TV group was co-administered 8% TV aqueous extract orally, 10 mL/kg/day with GM. Both RM and TV groups extracted significantly ameliorated plasma kidney function biomarkers, and reduced malondialdhyde and glucose levels. Meanwhile, RM extract significantly modulated the electrolyte concentration and increased plasma insulin levels as compared with the GM group. However, the aqueous extract of RM showed more pronounced effects than TV extract. Our data were confirmed by histopathological examination and deoxyribonucleic acid (DNA) fragmentation analysis. Deleterious histopathological changes and increased DNA fragmentation induced by GM treatment were markedly controlled by the co-administration of RM and TV. Such renoprotective influence of RM and TV suggests their concurrent supplementation with GM therapy to limit GM toxicity.

The Effects of Mental Imagery with Video-Modeling on Self-Efficacy and Maximal Front Squat Ability.

PubMed

Buck, Daniel J M; Hutchinson, Jasmin C; Winter, Christa R; Thompson, Brian A

2016-04-14

This study was designed to assess the effectiveness of mental imagery supplemented with video-modeling on self-efficacy and front squat strength (three repetition maximum; 3RM). Subjects (13 male, 7 female) who had at least 6 months of front squat experience were assigned to either an experimental ( n = 10) or a control ( n = 10) group. Subjects' 3RM and self-efficacy for the 3RM were measured at baseline. Following this, subjects in the experimental group followed a structured imagery protocol, incorporating video recordings of both their own 3RM performance and a model lifter with excellent technique, twice a day for three days. Subjects in the control group spent the same amount of time viewing a placebo video. Following three days with no physical training, measurements of front squat 3RM and self-efficacy for the 3RM were repeated. Subjects in the experimental group increased in self-efficacy following the intervention, and showed greater 3RM improvement than those in the control group. Self-efficacy was found to significantly mediate the relationship between imagery and front squat 3RM. These findings point to the importance of mental skills training for the enhancement of self-efficacy and front squat performance.

Phytoremediation of metals using lemongrass (Cymbopogon citratus (D.C.) Stapf.) grown under different levels of red mud in soil amended with biowastes.

PubMed

Gautam, Meenu; Pandey, Divya; Agrawal, Madhoolika

2017-06-03

Due to hostile condition of red mud (RM), its utilization for vegetation is restricted. Therefore, RM with biowastes as soil amendment may offer suitable combination to support plant growth with reduced risk of metal toxicity. To evaluate the effects of RM on soil properties, plant growth performance, and metal accumulation in lemongrass, a study was conducted using different RM concentrations (0, 5, 10, and 15% w/w) in soil amended with biowastes [cow dung manure (CD) or sewage-sludge (SS)]. Application of RM in soil with biowastes improved organic matter and nutrient contents and caused reduction in phytoavailable metal contents. Total plant biomass was increased under all treatments, maximally at 5% RM in soil with SS (91.4%) and CD (51.7%) compared to that in control (no RM and biowastes). Lemongrass acted as a potential metal-tolerant plant as its metal tolerance index is >100%. Based on translocation and bioconcentration factors, lemongrass acted as a potential phytostabilizer of Fe, Mn, and Cu in roots and was found efficient in translocation of Al, Zn, Cd, Pb, Cr, As, and Ni from roots to shoot. The study suggests that 5% RM with biowastes preferably SS may be used to enhance phytoremediation potential of lemongrass.

Remote monitoring for active cardiovascular implantable electronic devices: a European survey.

PubMed

Halimi, Franck; Cantù, Francesco

2010-12-01

This survey sampled today's European practices in the use of remote monitoring (RM) for the follow-up of active cardiovascular implantable electronic devices. Eighty-five per cent of the responding centres are currently using RM. For the majority, RM is expected to increase importantly within 5 years, and it has already led to a new organization of care based on dedicated allied professionals and/or the creation of RM units. There are still major limitations for the development of RM, such as ethical and legal aspects, reimbursement issues, and the lack of specific national- and European-updated guidelines which need to be informed.

Observations from Juno's Radiation Monitoring Investigation during Juno's Early Orbits

NASA Astrophysics Data System (ADS)

Becker, Heidi N.; Jorgensen, John L.; Adriani, Alberto; Mura, Alessandro; Connerney, John E. P.; Santos-Costa, Daniel; Bolton, Scott J.; Levin, Steven M.; Alexander, James W.; Adumitroaie, Virgil; Manor-Chapman, Emily A.; Daubar, Ingrid J.; Lee, Clifford; Benn, Mathias; Denver, Troelz; Sushkova, Julia; Cicchetti, Andrea; Noschese, Raffaella; Thorne, Richard M.

2017-04-01

Juno's Radiation Monitoring (RM) Investigation profiles Jupiter's >10-MeV electron environment throughout unexplored regions of the Jovian magnetosphere. RM's measurement approach involves active retrieval of the characteristic noise signatures from penetrating radiation in images obtained by Juno's heavily shielded star cameras and science instruments. Collaborative observation campaigns of "radiation image" collection and penetrating particle counts are conducted at targeted opportunities within the magnetosphere during each of Juno's perijove passes using the spacecraft Stellar Reference Unit, the Magnetic Field Investigation's Advanced Stellar Compass Imagers, and the JIRAM infrared imager. Simultaneous observations gathered from these very different instruments provide comparative spectral information due to substantial differences in instrument shielding. Juno's orbit provides a unique sampling of energetic particles within Jupiter's innermost radiation belts and polar regions. We present a survey of observations of the high energy radiation environment made by Juno's SRU and ASC star cameras and the JIRAM infrared imager during Juno's early perijove passes on August 27 and December 11, 2016; and February 2 and March 27, 2017. The JPL author's copyright for this publication is held by the California Institute of Technology. Government Sponsorship acknowledged.

Pattering of nanostructures with high aspect ratio in polymer materials

NASA Astrophysics Data System (ADS)

Lyuksyutov, Sergei; Paramonov, Pavel; Sancaktar, Erol; Vaia, Richard; Juhl, Shane

2004-04-01

The generation of features larger than the initial atomic force microscope (AFM) tip-surface distance (presumably less that 1nm for unbiased tip) had previously been reported for silicon and metal oxidation. Such nanostructure (1-50 nm high) formation exceeding AFM tip-sample separation has been observed by us during AFM-assisted nanolithography in polymers [1,2]. The technique produces nanostructures up to 100 nm high in thin (10-30 nm) polymer films through the one-step process. The specific spatial details of the tip-surface contact profile, as well as cantilever motion, with applied bias during writing is not well understood and we are not aware of any comprehensive explanation provided in literature for this effect. In this work we analyze tip-polymer interaction using real-time tip deflection. An abrupt lift-up of biased AFM tip has been recorded experimentally and found to be proportional to the height of polymer nanostructures. This fact was used to pattern robust nanostructures of 20-100 nm high using amplitude modulated AFM-assisted electrostatic nanolithography [2] as the arrays of dots in polystyrene and polybenzoxasole polymer films. References [1] S.F. Lyuksyutov, R.A. Vaia, P.B. Paramonov, S. Juhl, L. Waterhouse, R.M. Ralich, G. Sigalov, and E. Sancaktar, Nature Materials 2(7) 468-472 (2003) [2] S.F. Lyuksyutov, R.A. Vaia, P.B. Paramonov, and S. Juhl, Appl. Phys. Lett. 83 (21), 4405-4407 (2003)

Gestational age of pregnancy loss in women with unexplained recurrent miscarriage.

PubMed

Ticconi, Carlo; Giuliani, Emma; Sorge, Roberto; Patrizi, Lodovico; Piccione, Emilio; Pietropolli, Adalgisa

2016-03-01

The aim of this study was to investigate the gestational age (GA) of pregnancy loss in women with unexplained recurrent miscarriage (RM) and to determine whether the miscarriages occur at similar GA in RM women. This retrospective study was carried out in a university hospital and included 288 women with unexplained RM. The GA at which each miscarriage occurred was carefully determined. Overall, 739 miscarriages were analyzed. RM women had miscarriages at a median GA of 7 weeks (range: 3-20). In RM women, 47.2% (n = 136) experienced miscarriages within a 1-week range of GA and 53.4% (n = 154) had miscarriages in the same period of fetal development (pre-embryonic, embryonic or fetal). Women with unexplained RM tend to have miscarriages at the same GA, which is characteristic for each patient. © 2015 Japan Society of Obstetrics and Gynecology.

Present-day plate motions

NASA Technical Reports Server (NTRS)

Minster, J. B.; Jordan, T. H.

1977-01-01

A data set comprising 110 spreading rates, 78 transform fault azimuths and 142 earthquake slip vectors was inverted to yield a new instantaneous plate motion model, designated RM2. The mean averaging interval for the relative motion data was reduced to less than 3 My. A detailed comparison of RM2 with angular velocity vectors which best fit the data along individual plate boundaries indicates that RM2 performs close to optimally in most regions, with several notable exceptions. On the other hand, a previous estimate (RM1) failed to satisfy an extensive set of new data collected in the South Atlantic Ocean. It is shown that RM1 incorrectly predicts the plate kinematics in the South Atlantic because the presently available data are inconsistent with the plate geometry assumed in deriving RM1. It is demonstrated that this inconsistency can be remedied by postulating the existence of internal deformation with the Indian plate, although alternate explanations are possible.

One-Dimensional RuO2/Mn2O3 Hollow Architectures as Efficient Bifunctional Catalysts for Lithium-Oxygen Batteries.

PubMed

Yoon, Ki Ro; Lee, Gil Yong; Jung, Ji-Won; Kim, Nam-Hoon; Kim, Sang Ouk; Kim, Il-Doo

2016-03-09

Rational design and massive production of bifunctional catalysts with fast oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) kinetics are critical to the realization of highly efficient lithium-oxygen (Li-O2) batteries. Here, we first exploit two types of double-walled RuO2 and Mn2O3 composite fibers, i.e., (i) phase separated RuO2/Mn2O3 fiber-in-tube (RM-FIT) and (ii) multicomposite RuO2/Mn2O3 tube-in-tube (RM-TIT), by controlling ramping rate during electrospinning process. Both RM-FIT and RM-TIT exhibited excellent bifunctional electrocatalytic activities in alkaline media. The air electrodes using RM-FIT and RM-TIT showed enhanced overpotential characteristics and stable cyclability over 100 cycles in the Li-O2 cells, demonstrating high potential as efficient OER and ORR catalysts.

Experimental Study on Hot Metal Desulfurization Using Sintered Red Mud-Based Flux

NASA Astrophysics Data System (ADS)

Li, Fengshan; Zhang, Yanling; Guo, Zhancheng

2017-09-01

This research presents the results of laboratory and pilot-scale tests conducted on the use of sintered red mud (RM)-based flux in the hot metal desulfurization (HMD) process. Al2O3/Na2O in RM can decrease the melting point of lime-based slag and can work as a flux in the HMD process. Good slag fluidity was observed throughout the process, and high desulfurization rates ( 80%) with a low final S content (<0.02%) were experimentally obtained when the RM:CaO ratio was between 1.2:1 and 2.4:1. The pilot-scale test results indicated that a desulfurization rate as high as 91% and a S content <0.0099% could be acquired when RM:lime = 1:1, verifying the feasibility of using sintered RM-based flux in HMD. The data obtained provide important information for promoting the large-scale application of sintered RM in steelmaking.

Effectiveness of ProTaper Universal retreatment instruments used with rotary or reciprocating adaptive motion in the removal of root canal filling material.

PubMed

Capar, I D; Arslan, H; Ertas, H; Gök, T; Saygılı, G

2015-01-01

To compare the effectiveness of ProTaper Universal retreatment instruments with continuous rotation and adaptive motion (AM; a modified reciprocating motion that combines rotational and reciprocating motion) in the removal of filling material. Mesiobuccal root canals in 36 mandibular first molars were instrumented up to size F2 with the ProTaper Universal instrument (Dentsply Maillefer, Ballaigues, Switzerland) and filled using sealer and ProTaper Universal F2 gutta-percha cones. Gutta-percha was then down-packed and the root canal backfilled using the extruder hand-piece of the Elements Obturation System (SybronEndo, Orange, CA, USA). The teeth were assigned to two groups (n = 18), and removal of the root fillings was performed using one of the following techniques: group 1) ProTaper Universal retreatment files used with rotational motion (RM) and group 2) ProTaper Universal retreatment files used with adaptive motion (AM) (600° clockwise/0° counter-clockwise to 370° clockwise/50° counter-clockwise). The teeth were sectioned, and both halves were analysed at 8 × magnification. The percentage of remaining filling material was recorded. The data were analysed statistically using the Student's t-test at a 95% confidence level (P < 0.05). There was no significant difference between the groups with respect to the total time required for retreatment (P = 0.481). The AM technique left significantly less filling material than the RM method (P = 0.013). The use of ProTaper Universal retreatment files with adaptive motion removed more filling materials from root canals than the rotational movement. © 2014 International Endodontic Journal. Published by John Wiley & Sons Ltd.

The Office of the Materials Division

NASA Technical Reports Server (NTRS)

Ramsey, amanda J.

2004-01-01

I was assigned to the Materials Division, which consists of the following branches; the Advanced Metallics Branch/5120-RMM, Ceramics Branch/5130-RMC, Polymers Branch/5150-RMP, and the Durability and Protective Coatings Branch/5160-RMD. Mrs. Pamela Spinosi is my assigned mentor. She was assisted by Ms.Raysa Rodriguez/5100-RM and Mrs.Denise Prestien/5100-RM, who are both employed by InDyne, Inc. My primary assignment this past summer was working directly with Ms. Rodriguez, assisting her with setting up the Integrated Financial Management Program (IFMP) 5130-RMC/Branch procedures and logs. These duties consisted of creating various spreadsheets for each individual branch member, which were updated daily. It was not hard to familiarize myself with these duties since this is my second summer working with Ms Rodriguez at NASA Glenn Research Center. RMC ordering laboratory, supplies and equipment for the Basic Materials Laboratory (Building 106) using the IF'MP/Purchase Card (P-card), a NASA-wide software program. I entered into the IFMP/Travel and Requisitions System, new Travel Authorizations for the 5130-RMC Civil Servant Branch Members. I also entered and completed Travel Vouchers for the 5130-RMC Ceramics Branch. I assisted in the Division Office creating new Emergency Contact list for the Materials Division. I worked with Dr. Hugh Gray, the Division Chief, and Dr. Ajay Misra, the 5130-RMC Branch Chief, on priority action items, with a close deadline, for a large NASA Proposal. Another project was working closely with Ms. Rodriguez in organizing and preparing for Dr. Ajay K. Misra's SESCDP (two year detail). This consisted of organizing files, file folders, personal information, and recording all data material onto CD's and printing all presentations for display in binders. I attended numerous Branch meetings, and observed many changes in the Branch Management organization.

Assessment of Patient Perceptions About Web Telemonitoring Applied to Artificial Pancreas Use at Home

PubMed Central

Farret, Anne; Del Favero, Simone; Bruttomesso, Daniela; Renard, Eric

2014-01-01

Patients with chronic diseases as well as health care systems could benefit from telemedicine applications such as remote monitoring (RM). RM relies on a device that sends patients’ health data to a remote server accessible by care teams. Recent smartphone-based artificial pancreas (AP) systems collect comprehensive set of information and could therefore support the development of RM applied to diabetes. To better understand how RM could be integrated in future AP systems, we wanted to get patients’ opinion on this concept, as they are the final users of these systems. An online questionnaire with 11 items was sent to 20 experienced patients who tested AP and RM during our recent outpatient studies in France and Italy. We received 17 answers. All patients considered that during their participation in trials, RM was useful, reassuring, and essential. One-third wouldn’t have participated without it. When AP is commercialized, 88% of respondents think that AP should go with a RM tool, but it should be activated only at certain times, at first use or in case of difficulties (82%). Participants ask for technical support when a device fails (88%) and for medical help in case of prolonged hyperglycemia (65%) or severe or repeated hypoglycemia (53%), but not after each case of hypoglycemia (6%). More than 75% think that RM could help them to improve their blood glucose control. This preliminary work indicates that patients expect RM to be part of future AP development. Larger studies remain to be performed to investigate its usefulness and potential economic effectiveness. PMID:24876571

Respiratory morbidity among welders in the shipbuilding industry, Goa.

PubMed

Bhumika, Nateshan; Prabhu, Ganapati Vasant; Ferreira, Agnelo Menino; Kulkarni, Manoj Kumar; Vaz, Frederick Satiro; Singh, Zile

2012-05-01

Welding is pivotal in shipbuilding. The fumes and gases involved in welding may cause respiratory morbidity. To study the prevalence of respiratory morbidity (RM) among welders vis à vis among nonwelders and its association with certain relevant factors. A cross-sectional study of 276 welders and 276 nonwelders was conducted in the shipbuilding industry. An interviewer-administered questionnaire was followed by spirometric examination. Odds ratio and its 95% CI and two-way ANOVA. Prevalence of RM was found to be significantly higher among welders compared to nonwelders (who were comparable in age, duration of employment (DOE) and smoking habits,) with odds ratio (OR) of 1.78 (95% confidence interval (CI):1.20-2.63). Obstructive type of RM was predominant in both welders (26% (n = 73)) and nonwelders (17% (n = 49)) with welders being at a significantly higher risk (OR = 1.66 (95%: 1.10-2.49)). RM was commoner after the 40 years of age or after 20 years of employment in both groups. Smoking was associated with RM among welders (OR = 1.48, 95% CI: 1.24-1.75) as well as nonwelders (OR = 2.83, 95% CI: 2.26-3.54). Work-related respiratory symptoms (WRRS) was not found to be related to RM (OR = 1.69, 95% CI: 1.00-2.84). Consistent use of personal protective equipment (PPE) was protective against RM in welders (OR = 0.33, 95% CI: 0.28-0.37). Welders had a greater burden of RM and this was related to increasing age, DOE, smoking and inconsistent use of PPE. WRRS were not indicative of RM.

Relationship between the number of repetitions and selected percentages of one repetition maximum in free weight exercises in trained and untrained men.

PubMed

Shimano, Tomoko; Kraemer, William J; Spiering, Barry A; Volek, Jeff S; Hatfield, Disa L; Silvestre, Ricardo; Vingren, Jakob L; Fragala, Maren S; Maresh, Carl M; Fleck, Steven J; Newton, Robert U; Spreuwenberg, Luuk P B; Häkkinen, Keijo

2006-11-01

Resistance exercise intensity is commonly prescribed as a percent of 1 repetition maximum (1RM). However, the relationship between percent 1RM and the number of repetitions allowed remains poorly studied, especially using free weight exercises. The purpose of this study was to determine the maximal number of repetitions that trained (T) and untrained (UT) men can perform during free weight exercises at various percentages of 1RM. Eight T and 8 UT men were tested for 1RM strength. Then, subjects performed 1 set to failure at 60, 80, and 90% of 1RM in the back squat, bench press, and arm curl in a randomized, balanced design. There was a significant (p < 0.05) intensity x exercise interaction. More repetitions were performed during the back squat than the bench press or arm curl at 60% 1RM for T and UT. At 80 and 90% 1RM, there were significant differences between the back squat and other exercises; however, differences were much less pronounced. No differences in number of repetitions performed at a given exercise intensity were noted between T and UT (except during bench press at 90% 1RM). In conclusion, the number of repetitions performed at a given percent of 1RM is influenced by the amount of muscle mass used during the exercise, as more repetitions can be performed during the back squat than either the bench press or arm curl. Training status of the individual has a minimal impact on the number of repetitions performed at relative exercise intensity.

Time until diagnosis of clinical events with different remote monitoring systems in Implantable Cardioverter-Defibrillator patients.

PubMed

Söth-Hansen, Malene; Witt, Christoffer Tobias; Rasmussen, Mathis; Kristensen, Jens; Gerdes, Christian; Nielsen, Jens Cosedis

2018-05-24

Remote monitoring (RM) is an established technology integrated into routine follow-up of patients with implantable cardioverter-defibrillator (ICD). Current RM systems differ according to transmission frequency and alert definition. We aimed to compare time difference between detection and acknowledgement of clinically relevant events between four RM systems. We analyzed time delay between detection of ventricular arrhythmic and technical events by the ICD and acknowledgement by hospital staff in 1.802 consecutive patients followed with RM during September 2014 - August 2016. Devices from Biotronik (BIO, n=374), Boston Scientific (BSC, n=196), Medtronic (MDT, n=468) and St Jude Medical (SJM, n=764) were included. We identified all events from RM webpages and their acknowledgement with RM or at in-clinic follow-up. Events occurring during weekends were excluded. We included 3.472 events. Proportion of events acknowledged within 24 hours was 72%, 23%, 18% and 65% with BIO, BSC, MDT and SJM, respectively, with median times of 13, 222, 163 and 18 hours from detection to acknowledgement (p<0.001 for both comparisons between manufacturers). Including only events transmitted as alerts by RM, 72%, 68%, 61% and 65% for BIO, BSC, MDT and SJM, respectively were acknowledged within 24 hours. Variation in time to acknowledgement of ventricular tachyarrhythmia episodes not treated with shock therapy was the primary cause for the difference between manufacturers. Significant and clinically relevant differences in time delay from event detection to acknowledgement exist between RM systems. Varying definitions of which events RM transmits as alerts are important for the differences observed. Copyright © 2018. Published by Elsevier Inc.

Intestinal microbiota reduces genotoxic endpoints induced by high-energy protons.

PubMed

Maier, Irene; Berry, David M; Schiestl, Robert H

2014-01-01

Ionizing space radiation causes oxidative DNA damage and triggers oxidative stress responses, and compromised DNA repair mechanisms can lead to increased risk of carcinogenesis. Young adult mice with developed innate and adaptive immune systems that harbored either a conventional intestinal microbiota (CM) or an intestinal microbiota with a restricted microbial composition (RM) were irradiated with a total dose of 1 Gy delivered by high-energy protons (2.5 GeV/n, LET = 0.2-2 keV/μm) or silicon or iron ions (850 MeV/n, LET ≈ 50 keV/μm and 1 GeV/n, LET = 150 keV/μm, respectively). Six hours after whole-body irradiation, acute chromosomal DNA lesions were observed for RM mice but not CM mice. High-throughput rRNA gene sequencing of intestinal mucosal bacteria showed that Barnesiella intestinihominis and unclassified Bacterodiales were significantly more abundant in male RM mice than CM mice, and phylotype densities changed in irradiated mice. In addition, Helicobacter hepaticus and Bacteroides stercoris were higher in CM than RM mice. Elevated levels of persistently phosphorylated γ-H2AX were observed in RM mice exposed to high-energy protons compared to nonirradiated RM mice, and they also were associated with a decrease of the antioxidant glutathione in peripheral blood measured at four weeks after irradiation. After radiation exposure, CM mice showed lower levels of γ-H2AX phosphorylation than RM mice and an increase in specific RM-associated phylotypes, indicating a down-regulating force on DNA repair by differentially abundant phylotypes in RM versus a radiation-sensitive complex CM.

Securing Nuclear Materials: The 2010 Summit and Issues for Congress

DTIC Science & Technology

2010-04-16

http://www.state.gov/secretary/rm/2009a/10/130806.htm. 7 Attendees include Algeria, Argentina , Armenia, Australia, Belgium, Brazil, Canada, Chile...29 The Lugar Doctrine states, “The United States will use all of its military, diplomatic and economic power—without...risks within four years; 25. Calls upon all States to manage responsibly and minimize to the greatest extent that is technically and economically

RM2: rms error comparisons

NASA Technical Reports Server (NTRS)

Rice, R. F.

1976-01-01

The root-mean-square error performance measure is used to compare the relative performance of several widely known source coding algorithms with the RM2 image data compression system. The results demonstrate that RM2 has a uniformly significant performance advantage.

Levels of Interference in Long and Short-Term Memory Differentially Modulate Non-REM and REM Sleep.

PubMed

Fraize, Nicolas; Carponcy, Julien; Joseph, Mickaël Antoine; Comte, Jean-Christophe; Luppi, Pierre-Hervé; Libourel, Paul-Antoine; Salin, Paul-Antoine; Malleret, Gaël; Parmentier, Régis

2016-12-01

It is commonly accepted that sleep is beneficial to memory processes, but it is still unclear if this benefit originates from improved memory consolidation or enhanced information processing. It has thus been proposed that sleep may also promote forgetting of undesirable and non-essential memories, a process required for optimization of cognitive resources. We tested the hypothesis that non-rapid eye movement sleep (NREMS) promotes forgetting of irrelevant information, more specifically when processing information in working memory (WM), while REM sleep (REMS) facilitates the consolidation of important information. We recorded sleep patterns of rats trained in a radial maze in three different tasks engaging either the long-term or short-term storage of information, as well as a gradual level of interference. We observed a transient increase in REMS amount on the day the animal learned the rule of a long-term/reference memory task (RM), and, in contrast, a positive correlation between the performance of rats trained in a WM task involving an important processing of interference and the amount of NREMS or slow wave activity. Various oscillatory events were also differentially modulated by the type of training involved. Notably, NREMS spindles and REMS rapid theta increase with RM training, while sharp-wave ripples increase with all types of training. These results suggest that REMS, but also rapid oscillations occurring during NREMS would be specifically implicated in the long-term memory in RM, whereas NREMS and slow oscillations could be involved in the forgetting of irrelevant information required for WM. © 2016 Associated Professional Sleep Societies, LLC.

STRUCTURE IN THE ROTATION MEASURE SKY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stil, J. M.; Taylor, A. R.; Sunstrum, C.

2011-01-01

An analysis of structure in rotation measure (RM) across the sky based on the RM catalog of Taylor et al. is presented. Several resolved RM structures are identified with structure in the local interstellar medium, including radio loops I, II, and III, the Gum nebula, and the Orion-Eridanus superbubble. Structure functions (SFs) of RM are presented for selected areas, and maps of SF amplitude and slope across the sky are compared with H{alpha} intensity and diffuse polarized intensity. RM variance on an angular scale of 1{sup 0} is correlated with length of the line of sight through the Galaxy, withmore » a contribution from local structures. The slope of the SFs is less concentrated to the Galactic plane and less correlated with length of the line of sight through the Galaxy, suggesting a more local origin for RM structure on angular scales {approx}10{sup 0}. The RM variance is a factor of {approx}2 higher toward the South Galactic Pole than toward the North Galactic Pole, reflecting a more wide-spread asymmetry between the northern and southern Galactic hemispheres. Depolarization of diffuse Galactic synchrotron emission at latitudes <30{sup 0} can be explained largely by Faraday dispersion related to small-scale variance in RM, but the errors allow a significant contribution from differential Faraday rotation along the line of sight.« less

Effect of Fatigue Upon Performance and Electromyographic Activity in 6-RM Bench Press

PubMed Central

van den Tillaar, Roland; Saeterbakken, Atle

2014-01-01

The aim of this study was to examine the effect of fatigue during one set of 6-RM bench pressing upon the muscle patterning and performance. Fourteen resistance-trained males (age 22.5±2.0 years, stature 1.82±0.07 m, body mass 82.0±7.8 kg) conducted a 6-RM bench press protocol. Barbell kinematics and EMG activity of pectoralis major, deltoid anterior, biceps brachii, triceps brachii, rectus abdominis, oblique external and erector spinae were measured in each repetition during the 6-RM bench press. Total lifting time increased and the velocity in the ascending movement decreased (p≤0.001). However, the kinematics in the descending phase deferred: the time decreased and velocity increased during the 6-RM (p≤0.001). Generally, muscles increased their EMG amplitude during the six repetitions in the ascending movement, while only three of the seven measured muscles showed an increase over the six repetitions in the descending part in 6-RM bench pressing. It was concluded that the bench pressing performance decreased (lower barbell velocities and longer lifting times) with increasing fatigue in the 6-RM execution. Furthermore EMG increased in the prime movers and the trunk stabilizers (abdominal and spine), while the antagonist muscle (biceps) activity was not affected by fatigue during the lifting phase in a single set of 6-RM bench pressing PMID:25031673

Effect of Fatigue Upon Performance and Electromyographic Activity in 6-RM Bench Press.

PubMed

van den Tillaar, Roland; Saeterbakken, Atle

2014-03-27

The aim of this study was to examine the effect of fatigue during one set of 6-RM bench pressing upon the muscle patterning and performance. Fourteen resistance-trained males (age 22.5±2.0 years, stature 1.82±0.07 m, body mass 82.0±7.8 kg) conducted a 6-RM bench press protocol. Barbell kinematics and EMG activity of pectoralis major, deltoid anterior, biceps brachii, triceps brachii, rectus abdominis, oblique external and erector spinae were measured in each repetition during the 6-RM bench press. Total lifting time increased and the velocity in the ascending movement decreased (p≤0.001). However, the kinematics in the descending phase deferred: the time decreased and velocity increased during the 6-RM (p≤0.001). Generally, muscles increased their EMG amplitude during the six repetitions in the ascending movement, while only three of the seven measured muscles showed an increase over the six repetitions in the descending part in 6-RM bench pressing. It was concluded that the bench pressing performance decreased (lower barbell velocities and longer lifting times) with increasing fatigue in the 6-RM execution. Furthermore EMG increased in the prime movers and the trunk stabilizers (abdominal and spine), while the antagonist muscle (biceps) activity was not affected by fatigue during the lifting phase in a single set of 6-RM bench pressing.

Establishing a proactive safety and health risk management system in the fire service.

PubMed

Poplin, Gerald S; Pollack, Keshia M; Griffin, Stephanie; Day-Nash, Virginia; Peate, Wayne F; Nied, Ed; Gulotta, John; Burgess, Jefferey L

2015-04-19

Formalized risk management (RM) is an internationally accepted process for reducing hazards in the workplace, with defined steps including hazard scoping, risk assessment, and implementation of controls, all within an iterative process. While required for all industry in the European Union and widely used elsewhere, the United States maintains a compliance-based regulatory structure, rather than one based on systematic, risk-based methodologies. Firefighting is a hazardous profession, with high injury, illness, and fatality rates compared with other occupations, and implementation of RM programs has the potential to greatly improve firefighter safety and health; however, no descriptions of RM implementation are in the peer-reviewed literature for the North American fire service. In this paper we describe the steps used to design and implement the RM process in a moderately-sized fire department, with particular focus on prioritizing and managing injury hazards during patient transport, fireground, and physical exercise procedures. Hazard scoping and formalized risk assessments are described, in addition to the identification of participatory-led injury control strategies. Process evaluation methods were conducted to primarily assess the feasibility of voluntarily instituting the RM approach within the fire service setting. The RM process was well accepted by the fire department and led to development of 45 hazard specific-interventions. Qualitative data documenting the implementation of the RM process revealed that participants emphasized the: value of the RM process, especially the participatory bottom-up approach; usefulness of the RM process for breaking down tasks to identify potential risks; and potential of RM for reducing firefighter injury. As implemented, this risk-based approach used to identify and manage occupational hazards and risks was successful and is deemed feasible for U.S. (and other) fire services. While several barriers and challenges do exist in the implementation of any intervention such as this, recommendations for adopting the process are provided. Additional work will be performed to determine the effectiveness of select controls strategies that were implemented; however participants throughout the organizational structure perceived the RM process to be of high utility while researchers also found the process improved the awareness and engagement in actively enhancing worker safety and health.

Evaluation of a novel GRPR antagonist for prostate cancer PET imaging: [64Cu]-DOTHA2-PEG-RM26.

PubMed

Mansour, Nematallah; Paquette, Michel; Ait-Mohand, Samia; Dumulon-Perreault, Véronique; Guérin, Brigitte

2018-01-01

Gastrin releasing peptide receptors (GRPRs) are significantly over-expressed on a large proportion of prostate cancers making them prime candidates for receptor-mediated nuclear imaging by PET. Recently, we synthesized a novel bifunctional chelator (BFC) bearing hydroxamic acid arms (DOTHA 2 ). Here we investigated the potential of a novel DOTHA 2 -conjugated, 64 Cu-radiolabeled GRPR peptide antagonist, [D-Phe 6 -Sta 13 -Leu 14 -NH 2 ]bombesin(6-14) (DOTHA 2 -PEG-RM26) to visualize prostate tumors by PET imaging. DOTHA 2 -PEG-RM26 was conveniently and efficiently assembled on solid support. The compound was radiolabeled with 64 Cu and its affinity, stability, cellular uptake on PC3 prostate cancer cells were evaluated. The in vitro and in vivo behavior of [ 64 Cu]DOTHA 2 -PEG-RM26 was examined by PET imaging using human PC3 prostate cancer xenografts and its behavior was compared to that of the analogous [ 64 Cu]NOTA-PEG-RM26. The inhibition constant of nat Cu-DOTHA 2 -PEG-RM26 was in the low nanomolar range (0.68±0.19 nM). The [ 64 Cu]DOTHA 2 -PEG-RM26 conjugate was prepared with a labeling yield >95% and molar activity of 56±3 GBq/μmol after a 5-min room temperature labeling. [ 64 Cu]-DOTHA 2 -PEG-RM26 demonstrated rapid blood and renal clearance as well as a high tumor uptake. Small animal PET images confirmed high and specific uptake in PC3 tumor. Both [ 64 Cu]-DOTHA 2 -PEG-RM26 and [ 64 Cu]-NOTA-PEG-RM26 displayed similar tumor and normal tissue uptakes at early time point post injection. [ 64 Cu]-DOTHA 2 -PEG-RM26 allows visualization of prostate tumors by PET imaging. DOTHA 2 enables fast 64 Cu chelation under mild condition, and as such could be used advantageously for the development of other 64 Cu-labeled peptide-derived PET tracers. Copyright © 2017 Elsevier Inc. All rights reserved.

The Role of the Y-Chromosome in the Establishment of Murine Hybrid Dysgenesis and in the Analysis of the Nucleotide Sequence Organization, Genetic Transmission and Evolution of Repeated Sequences.

NASA Astrophysics Data System (ADS)

Nallaseth, Ferez Soli

The Y-chromosome presents a unique cytogenetic framework for the evolution of nucleotide sequences. Alignment of nine Y-chromosomal fragments in their increasing Y-specific/non Y-specific (male/female) sequence divergence ratios was directly and inversely related to their interspersion on these two respective genomic fractions. Sequence analysis confirmed a direct relationship between divergence ratios and the Alu, LINE-1, Satellite and their derivative oligonucleotide contents. Thus their relocation on the Y-chromosome is followed by sequence divergence rather than the well documented concerted evolution of these non-coding progenitor repeated sequences. Five of the nine Y-chromosomal fragments are non-pseudoautosomal and transcribed into heterogeneous PolyA^+ RNA and thus can be retrotransposed. Evolutionary and computer analysis identified homologous oligonucleotide tracts in several human loci suggesting common and random mechanistic origins. Dysgenic genomes represent the accelerated evolution driving sequence divergence (McClintock, 1984). Sex reversal and sterility characterizing dysgenesis occurs in C57BL/6JY ^{rm Pos} but not in 129/SvY^{rm Pos} derivative strains. High frequency, random, multi-locus deletion products of the feral Y^{ rm Pos}-chromosome are generated in the germlines of F1(C57BL/6J X 129/SvY^{ rm Pos})(male) and C57BL/6JY ^{rm Pos}(male) but not in 129/SvY^{rm Pos}(male). Equal, 10^{-1}, 10^ {-2}, and 0 copies (relative to males) of Y^{rm Pos}-specific deletion products respectively characterize C57BL/6JY ^{rm Pos} (HC), (LC), (T) and (F) females. The testes determining loci of inactive Y^{rm Pos}-chromosomes in C57BL/6JY^{rm Pos} HC females are the preferentially deleted/rearranged Y ^{rm Pos}-sequences. Disruption of regulation of plasma testosterone and hepatic MUP-A mRNA levels, TRD of a 4.7 Kbp EcoR1 fragment suggest disruption of autosomal/X-chromosomal sequences. These data and the highly repeated progenitor (Alu, GATA, LINE-1) sequence content of deletion products confirmed the previously unidentified loss of genetic control of mammalian chromosome biology and hybrid dysgenesis.

The Formation of Supermassive Black Holes from Population III.1 Seeds. I. Cosmic Formation Histories and Clustering Properties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banik, Nilanjan; Tan, Jonathan C.; Monaco, Pierluigi

We calculate the cosmic distributions in space and time of the formation sites of the first, "Pop III.1" stars, exploring a model in which these are the progenitors of all supermassive black holes (SMBHs). Pop III.1 stars are defined to form from primordial composition gas in dark matter minihalos withmore » $$\\sim10^6\\:M_\\odot$$ that are isolated from neighboring astrophysical sources by a given isolation distance, $$d_{\\rm{iso}}$$. We assume Pop III.1 sources are seeds of SMBHs, based on protostellar support by dark matter annihilation heating that allows them to accrete a large fraction of their minihalo gas, i.e., $$\\sim 10^5\\:M_\\odot$$. Exploring $$d_{\\rm{iso}}$$ from 10--$$100\\:\\rm{kpc}$$ (proper distances), we predict the redshift evolution of Pop III.1 source and SMBH remnant number densities. The local, $z=0$ density of SMBHs constrains $$d_{\\rm{iso}}\\lesssim 100\\:\\rm{kpc}$$ (i.e., $$3\\:\\rm{Mpc}$$ comoving distance at $$z\\simeq30$$). In our simulated ($$\\sim60\\:\\rm{Mpc}$$)$^3$ comoving volume, Pop III.1 stars start forming just after $z=40$. Their formation is largely complete by $$z\\simeq25$$ to 20 for $$d_{\\rm{iso}}=100$$ to $$50\\:\\rm{kpc}$$. We follow source evolution to $z=10$, by which point most SMBHs reside in halos with $$\\gtrsim10^8\\:M_\\odot$$. Over this period, there is relatively limited merging of SMBHs for these values of $$d_{\\rm{iso}}$$. We also predict SMBH clustering properties at $z=10$$: feedback suppression of neighboring sources leads to relatively flat angular correlation functions. Finally, we consider a simple "Str\\"omgren" model for $$d_{\\rm iso}$, based on ionizing feedback from zero age main sequence supermassive Pop III.1 stars that may be the direct progenitors of SMBHs in this scenario. Such models naturally produce feedback effects on scales of $$\\sim100\\:$$kpc and thus self-consistently generate a SMBH number density similar to the observed value.« less

THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: TECHNICAL OVERVIEW

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Yue; Brandt, W. N.; Dawson, Kyle S.

2015-01-01

The Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg{sup 2} field with the SDSS-III Baryon Oscillation Spectroscopic Survey spectrograph. The RM quasar sample is flux-limited to i {sub psf} = 21.7 mag, and covers a redshift range of 0.1 < z < 4.5 without any other cuts on quasar properties. Optical spectroscopy was performed during 2014 January-July dark/gray time, with an average cadence of ∼4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bandsmore » was conducted at multiple facilities including the Canada-France-Hawaii Telescope (CFHT) and the Steward Observatory Bok telescope in 2014, with a cadence of ∼2 days and covering all lunar phases. The RM field (R.A., decl. = 14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM six month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ∼10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z > 0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design, and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science.« less

Long-term variability in sugarcane bagasse feedstock compositional methods: Sources and magnitude of analytical variability

DOE PAGES

Templeton, David W.; Sluiter, Justin B.; Sluiter, Amie; ...

2016-10-18

In an effort to find economical, carbon-neutral transportation fuels, biomass feedstock compositional analysis methods are used to monitor, compare, and improve biofuel conversion processes. These methods are empirical, and the analytical variability seen in the feedstock compositional data propagates into variability in the conversion yields, component balances, mass balances, and ultimately the minimum ethanol selling price (MESP). We report the average composition and standard deviations of 119 individually extracted National Institute of Standards and Technology (NIST) bagasse [Reference Material (RM) 8491] run by seven analysts over 7 years. Two additional datasets, using bulk-extracted bagasse (containing 58 and 291 replicates each),more » were examined to separate out the effects of batch, analyst, sugar recovery standard calculation method, and extractions from the total analytical variability seen in the individually extracted dataset. We believe this is the world's largest NIST bagasse compositional analysis dataset and it provides unique insight into the long-term analytical variability. Understanding the long-term variability of the feedstock analysis will help determine the minimum difference that can be detected in yield, mass balance, and efficiency calculations. The long-term data show consistent bagasse component values through time and by different analysts. This suggests that the standard compositional analysis methods were performed consistently and that the bagasse RM itself remained unchanged during this time period. The long-term variability seen here is generally higher than short-term variabilities. It is worth noting that the effect of short-term or long-term feedstock compositional variability on MESP is small, about $0.03 per gallon. The long-term analysis variabilities reported here are plausible minimum values for these methods, though not necessarily average or expected variabilities. We must emphasize the importance of training and good analytical procedures needed to generate this data. As a result, when combined with a robust QA/QC oversight protocol, these empirical methods can be relied upon to generate high-quality data over a long period of time.« less

Long-term variability in sugarcane bagasse feedstock compositional methods: Sources and magnitude of analytical variability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Templeton, David W.; Sluiter, Justin B.; Sluiter, Amie

In an effort to find economical, carbon-neutral transportation fuels, biomass feedstock compositional analysis methods are used to monitor, compare, and improve biofuel conversion processes. These methods are empirical, and the analytical variability seen in the feedstock compositional data propagates into variability in the conversion yields, component balances, mass balances, and ultimately the minimum ethanol selling price (MESP). We report the average composition and standard deviations of 119 individually extracted National Institute of Standards and Technology (NIST) bagasse [Reference Material (RM) 8491] run by seven analysts over 7 years. Two additional datasets, using bulk-extracted bagasse (containing 58 and 291 replicates each),more » were examined to separate out the effects of batch, analyst, sugar recovery standard calculation method, and extractions from the total analytical variability seen in the individually extracted dataset. We believe this is the world's largest NIST bagasse compositional analysis dataset and it provides unique insight into the long-term analytical variability. Understanding the long-term variability of the feedstock analysis will help determine the minimum difference that can be detected in yield, mass balance, and efficiency calculations. The long-term data show consistent bagasse component values through time and by different analysts. This suggests that the standard compositional analysis methods were performed consistently and that the bagasse RM itself remained unchanged during this time period. The long-term variability seen here is generally higher than short-term variabilities. It is worth noting that the effect of short-term or long-term feedstock compositional variability on MESP is small, about $0.03 per gallon. The long-term analysis variabilities reported here are plausible minimum values for these methods, though not necessarily average or expected variabilities. We must emphasize the importance of training and good analytical procedures needed to generate this data. As a result, when combined with a robust QA/QC oversight protocol, these empirical methods can be relied upon to generate high-quality data over a long period of time.« less

Memory systems in the rat: effects of reward probability, context, and congruency between working and reference memory.

PubMed

Roberts, William A; Guitar, Nicole A; Marsh, Heidi L; MacDonald, Hayden

2016-05-01

The interaction of working and reference memory was studied in rats on an eight-arm radial maze. In two experiments, rats were trained to perform working memory and reference memory tasks. On working memory trials, they were allowed to enter four randomly chosen arms for reward in a study phase and then had to choose the unentered arms for reward in a test phase. On reference memory trials, they had to learn to visit the same four arms on the maze on every trial for reward. Retention was tested on working memory trials in which the interval between the study and test phase was 15 s, 15 min, or 30 min. At each retention interval, tests were performed in which the correct WM arms were either congruent or incongruent with the correct RM arms. Both experiments showed that congruency interacted with retention interval, yielding more forgetting at 30 min on incongruent trials than on congruent trials. The effect of reference memory strength on the congruency effect was examined in Experiment 1, and the effect of associating different contexts with working and reference memory on the congruency effect was studied in Experiment 2.

Validity of a Commercial Linear Encoder to Estimate Bench Press 1 RM from the Force-Velocity Relationship.

PubMed

Bosquet, Laurent; Porta-Benache, Jeremy; Blais, Jérôme

2010-01-01

The aim of this study was to assess the validity and accuracy of a commercial linear encoder (Musclelab, Ergotest, Norway) to estimate Bench press 1 repetition maximum (1RM) from the force - velocity relationship. Twenty seven physical education students and teachers (5 women and 22 men) with a heterogeneous history of strength training participated in this study. They performed a 1 RM test and a force - velocity test using a Bench press lifting task in a random order. Mean 1 RM was 61.8 ± 15.3 kg (range: 34 to 100 kg), while 1 RM estimated by the Musclelab's software from the force-velocity relationship was 56.4 ± 14.0 kg (range: 33 to 91 kg). Actual and estimated 1 RM were very highly correlated (r = 0.93, p<0.001) but largely different (Bias: 5.4 ± 5.7 kg, p < 0.001, ES = 1.37). The 95% limits of agreement were ±11.2 kg, which represented ±18% of actual 1 RM. It was concluded that 1 RM estimated from the force-velocity relationship was a good measure for monitoring training induced adaptations, but also that it was not accurate enough to prescribe training intensities. Additional studies are required to determine whether accuracy is affected by age, sex or initial level. Key pointsSome commercial devices allow to estimate 1 RM from the force-velocity relationship.These estimations are valid. However, their accuracy is not high enough to be of practical help for training intensity prescription.Day-to-day reliability of force and velocity measured by the linear encoder has been shown to be very high, but the specific reliability of 1 RM estimated from the force-velocity relationship has to be determined before concluding to the usefulness of this approach in the monitoring of training induced adaptations.

Validity of a Commercial Linear Encoder to Estimate Bench Press 1 RM from the Force-Velocity Relationship

PubMed Central

Bosquet, Laurent; Porta-Benache, Jeremy; Blais, Jérôme

2010-01-01

The aim of this study was to assess the validity and accuracy of a commercial linear encoder (Musclelab, Ergotest, Norway) to estimate Bench press 1 repetition maximum (1RM) from the force - velocity relationship. Twenty seven physical education students and teachers (5 women and 22 men) with a heterogeneous history of strength training participated in this study. They performed a 1 RM test and a force - velocity test using a Bench press lifting task in a random order. Mean 1 RM was 61.8 ± 15.3 kg (range: 34 to 100 kg), while 1 RM estimated by the Musclelab’s software from the force-velocity relationship was 56.4 ± 14.0 kg (range: 33 to 91 kg). Actual and estimated 1 RM were very highly correlated (r = 0.93, p<0.001) but largely different (Bias: 5.4 ± 5.7 kg, p < 0.001, ES = 1.37). The 95% limits of agreement were ±11.2 kg, which represented ±18% of actual 1 RM. It was concluded that 1 RM estimated from the force-velocity relationship was a good measure for monitoring training induced adaptations, but also that it was not accurate enough to prescribe training intensities. Additional studies are required to determine whether accuracy is affected by age, sex or initial level. Key points Some commercial devices allow to estimate 1 RM from the force-velocity relationship. These estimations are valid. However, their accuracy is not high enough to be of practical help for training intensity prescription. Day-to-day reliability of force and velocity measured by the linear encoder has been shown to be very high, but the specific reliability of 1 RM estimated from the force-velocity relationship has to be determined before concluding to the usefulness of this approach in the monitoring of training induced adaptations. PMID:24149641

Effect of a mixture of iprobenfos and malathion on the development of malathion resistance in the mosquito Culex pipiens pallens Coq.

PubMed

Tao, Li-Ming; Yang, Jian-Zhong; Zhuang, Pei-Jun; Tang, Zhen-Hua

2006-01-01

A malathion-resistant (RM) strain of Culex pipiens pallens Coq was obtained by successively selecting a field population with malathion in the laboratory. The synergistic effect of iprobenfos on malathion toxicity and alpha-naphthyl acetate (alpha-NA) esterase assay revealed that malathion resistance in the RM strain was associated with increased alpha-NA esterase activity and the synergism was mainly due to the inhibition by iprobenfos of this activity. There was no difference in alpha-NA esterase activity between the larvae and female adults in the susceptible (S) strain, but the activity in the adults was 13-fold higher than in the larvae of the RM strain. To understand the effect of the application of a mixture of iprobenfos and malathion on the evolution of malathion resistance, an artificial strain (Syn) was generated by mixing the RM and S strains with 0.1 frequency of the malathion-resistant individuals. The offspring of the Syn strain were divided into two sub-strains, Rm and Rm+ibp, which were successively treated with, respectively, malathion alone and malathion + iprobenfos (1:2) at LC70. In the mixture, the fungicide iprobenfos acted as a synergist of malathion. After treatment for 10 generations, the resistance level to malathion was 317.4-fold for the Rm sub-strain, whereas for the Rm+ibp sub-strain it was only 38.9-fold, compared with the Syn strain. Similar results were obtained by measurement of alpha-NA esterase activity from both larvae and female adults. The alpha-NA esterase activities in larvae and female adults at F10 generation were 2.6- and 10.9-fold from the Rm+ibp sub-strain and 5.7- and 98.5-fold from the Rm sub-strain, respectively, compared with the Syn strain. The above results suggested that iprobenfos, although it cannot completely stop or prevent the onset of malathion resistance, could dramatically delay its evolution. Copyright 2005 Society of Chemical Industry.

Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach.

PubMed

Mo, SangJoon; Lee, Sung-Kwon; Jin, Ying-Yu; Suh, Joo-Won

2016-02-01

FK506, a widely used immunosuppressant, is a 23-membered polyketide macrolide that is produced by several Streptomyces species. FK506 high-yielding strain Streptomyces sp. RM7011 was developed from the discovered Streptomyces sp. KCCM 11116P by random mutagenesis in our previous study. The results of transcript expression analysis showed that the transcription levels of tcsA, B, C, and D were increased in Streptomyces sp. RM7011 by 2.1-, 3.1-, 3.3-, and 4.1- fold, respectively, compared with Streptomyces sp. KCCM 11116P. The overexpression of tcsABCD genes in Streptomyces sp. RM7011 gave rise to approximately 2.5-fold (238.1 μg/ml) increase in the level of FK506 production compared with that of Streptomyces sp. RM7011. When vinyl pentanoate was added into the culture broth of Streptomyces sp. RM7011, the level of FK506 production was approximately 2.2-fold (207.7 μg/ml) higher than that of the unsupplemented fermentation. Furthermore, supplementing the culture broth of Streptomyces sp. RM7011 expressing tcsABCD genes with vinyl pentanoate resulted in an additional 1.7-fold improvement in the FK506 titer (498.1 μg/ml) compared with that observed under nonsupplemented condition. Overall, the level of FK506 production was increased approximately 5.2-fold by engineering the supply of allylmalonyl-CoA in the high-yielding strain Streptomyces sp. RM7011, using a combination of overexpressing tcsABCD genes and adding vinyl pentanoate, as compared with Streptomyces sp. RM7011 (95.3 μg/ml). Moreover, among the three precursors analyzed, pentanoate was the most effective precursor, supporting the highest titer of FK506 in the FK506 high-yielding strain Streptomyces sp. RM7011.

Restoration of red mud deposits by naturally growing vegetation.

PubMed

Mishra, Tripti; Singh, N B; Singh, Nandita

2017-05-04

Disposal of red mud (RM) poses serious environmental problems such as wind erosion, air and water pollution. To overcome these problems, effective restoration of the disposal land through naturally growing vegetation is a sustainable and economical approach. The present study involved estimation of frequency (F), density (D), abundance (Ab), and important value index (IVI) of natural flora on abandoned RM sites in order to assess their metal toxicity tolerance capacity. Based on visual observations and highest IVI, S. Asper and S. punicea were identified as effective ecological tools for the restoration of barren RM sites. From the study, remarkable differences were observed between non-rhizospheric and rhizospheric RM of both species. These rhizospheric RM analyses confirm the ability of S. asper and S. punicea for enhancing the biological activities of abandoned RM. Translocation factor (TF) of iron was maximum (2.58) in S. asper, and bioconcentration factor (BCF) was found maximum (1.25) in S. punicea, but both TF (2.58) and BCF (1.35) were high in S. asper. Therefore, this plant could be reported as an iron hyperaccumulator plant. These results suggest that these plant species can be exploited for effective restoration of RM deposited land without any inputs or maintenance.

Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer.

PubMed

Ding, Hui; Lv, Yanlin; Ni, Dezhi; Wang, Jie; Tian, Zhiyuan; Wei, Wei; Ma, Guanghui

2015-06-07

A new type of photodynamic therapy (PDT) agents using upconversion nanoparticles (UCNPs) with incorporated photosensitizers as the inner core and an erythrocyte membrane (RM) decorated with dual targeting moieties as the cloak is developed. Owing to the endogenous nature of RM, the RM-coating endows the PDT agents with perfect biocompatibility and stealth ability to escape from the entrapment by the reticulo-endothelial system (RES). More importantly, owing to the unique nature of erythrocyte as an oxygen carrier in the blood, the RM outer layer of the agents unequivocally facilitates the permeation of ground-state molecular oxygen ((3)O2) and the singlet oxygen ((1)O2) as compared to the previously developed PDT agents with other types of coating. Another salient feature of the as-prepared PDT platform is the decoration of RM with dual targeting moieties for selective recognition of cancer cells and mitochondrial targeting, respectively. The synergistic effect of RM coating and dual-targeting of such feature-packed agents are investigated in tumor-bearing mice and the improved PDT therapeutic efficacy is confirmed, which is the first paradigm where RM-coated NIR-triggered nanovectors with programmed delivery ability is applied in PDT of tumor in vivo.

Graphic methods for interpreting longitudinal dyadic patterns from repeated-measures actor-partner interdependence models.

PubMed

Perry, Nicholas S; Baucom, Katherine J W; Bourne, Stacia; Butner, Jonathan; Crenshaw, Alexander O; Hogan, Jasara N; Imel, Zac E; Wiltshire, Travis J; Baucom, Brian R W

2017-08-01

Researchers commonly use repeated-measures actor-partner interdependence models (RM-APIM) to understand how romantic partners change in relation to one another over time. However, traditional interpretations of the results of these models do not fully or correctly capture the dyadic temporal patterns estimated in RM-APIM. Interpretation of results from these models largely focuses on the meaning of single-parameter estimates in isolation from all the others. However, considering individual coefficients separately impedes the understanding of how these associations combine to produce an interdependent pattern that emerges over time. Additionally, positive within-person, or actor, effects are commonly misinterpreted as indicating growth from one time point to the next when they actually represent decline. We suggest that change-as-outcome RM-APIMs and vector field diagrams (VFDs) can be used to improve the understanding and presentation of dyadic patterns of association described by standard RM-APIMs. The current article briefly reviews the conceptual foundations of RM-APIMs, demonstrates how change-as-outcome RM-APIMs and VFDs can aid interpretation of standard RM-APIMs, and provides a tutorial in making VFDs using multilevel modeling. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Yersinia ruckeri sp. nov., the redmouth (RM) bacterium

USGS Publications Warehouse

Ewing, W.H.; Ross, A.J.; Brenner, Don J.; Fanning, G. R.

1978-01-01

Cultures of the redmouth (RM) bacterium, one of the etiological agents of redmouth disease in rainbow trout (Salmo gairdneri) and certain other fishes, were characterized by means of their biochemical reactions, by deoxyribonucleic acid (DNA) hybridization, and by determination of guanine-plus-cytosine (G+C) ratios in DNA. The DNA relatedness studies confirmed the fact that the RM bacteria are members of the family Enterobacteriaceae and that they comprise a single species that is not closely related to any other species of Enterobacteriaceae. They are about 30% related to species of both Serratia and Yersinia. A comparison of the biochemical reactions of RM bacteria and serratiae indicated that there are many differences between these organisms and that biochemically the RM bacteria are most closely related to yersiniae. The G+C ratios of RM bacteria were approximated to be between 47.5 and 48.5% These values are similar to those of yersiniae but markedly different from those of serratiae. On the basis of their biochemical reactions and their G+C ratios, the RM bacteria are considered to be a new species of Yersinia, for which the name Yersinia ruckeri is proposed. Strain 2396-61 (= ATCC 29473) is designated the type strain of the species.

Reliability of Strength Testing using the Advanced Resistive Exercise Device and Free Weights

NASA Technical Reports Server (NTRS)

English, Kirk L.; Loehr, James A.; Laughlin, Mitzi A.; Lee, Stuart M. C.; Hagan, R. Donald

2008-01-01

The Advanced Resistive Exercise Device (ARED) was developed for use on the International Space Station as a countermeasure against muscle atrophy and decreased strength. This investigation examined the reliability of one-repetition maximum (1RM) strength testing using ARED and traditional free weight (FW) exercise. Methods: Six males (180.8 +/- 4.3 cm, 83.6 +/- 6.4 kg, 36 +/- 8 y, mean +/- SD) who had not engaged in resistive exercise for at least six months volunteered to participate in this project. Subjects completed four 1RM testing sessions each for FW and ARED (eight total sessions) using a balanced, randomized, crossover design. All testing using one device was completed before progressing to the other. During each session, 1RM was measured for the squat, heel raise, and deadlift exercises. Generalizability (G) and intraclass correlation coefficients (ICC) were calculated for each exercise on each device and were used to predict the number of sessions needed to obtain a reliable 1RM measurement (G . 0.90). Interclass reliability coefficients and Pearson's correlation coefficients (R) also were calculated for the highest 1RM value (1RM9sub peak)) obtained for each exercise on each device to quantify 1RM relationships between devices.

Risk Management in EVA

NASA Technical Reports Server (NTRS)

Hall, Jonathan; Lutomski, M.

2006-01-01

This viewgraph presentation reviews the use of risk management in Extravehicular Activities (EVA). The contents include: 1) EVA Office at NASA - JSC; 2) EVA Project Risk Management: Why and When; 3) EVA Office Risk Management: How; 4) Criteria for Closing a Risk; 5) Criteria for Accepting a Risk; 6) ISS IRMA Reference Card Data Entry Requirement s; 7) XA/ EVA Office Risk Activity Summary; 8) EVA Significant Change Summary; 9) Integrated Risk Management Application (XA) Matrix, March 31, 2004; 10) ISS Watch Item: 50XX Summary Report; and 11) EVA Project RM Usefulness

LANDSAT-D data format control book. Volume 6, appendix K: Unprocessed multispectral scanner high density tape (HDT-RM/HDT-GM)

NASA Technical Reports Server (NTRS)

Andersen, K. E.

1981-01-01

Unprocessed MSS data which is recorded on HDT-RM (a 28 track, high density tape) and on HDT-GM (a 14 track, nonbias recorded, high density tape) are inputs for the LANDSAT 4 data management system. All MSS data initially recorded on HDT-GM are copied to HDT-RM prior to processing. This specification establishes the requirements for the format of the LANDSAT D HDT-RM/HDT-GM.

Crystal structure and characterization of a novel L-serine ammonia-lyase from Rhizomucor miehei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qin, Zhen; Yan, Qiaojuan; Ma, Qingjun

L-serine ammonia-lyase, as a member of the β-family of pyridoxal-5′-phosphate (PLP) dependent enzymes, catalyzes the conversion of L-serine (L-threonine) to pyruvate (α-ketobutyrate) and ammonia. The crystal structure of L-serine ammonia-lyase from Rhizomucor miehei (RmSDH) was solved at 1.76 Å resolution by X-ray diffraction method. The overall structure of RmSDH had the characteristic β-family PLP dependent enzyme fold. It consisted of two distinct domains, both of which show the typical open twisted α/β structure. A PLP cofactor was located in the crevice between the two domains, which was attached to Lys52 by a Schiff-base linkage. Unique residue substitutions (Gly78, Pro79, Ser146, Ser147more » and Thr312) were discovered at the catalytic site of RmSDH by comparison of structures of RmSDH and other reported eukaryotic L-serine ammonia-lyases. Optimal pH and temperature of the purified RmSDH were 7.5 and 40 °C, respectively. It was stable in the pH range of 7.0–9.0 and at temperatures below 40 °C. This is the first crystal structure of a fungal L-serine ammonia-lyase. It will be useful to study the catalytic mechanism of β-elimination enzymes and will provide a basis for further enzyme engineering. - Highlights: • The crystal structure of a fungal L-serine ammonia-lyase (RmSDH) was solved. • Five unique residue substitutions are found at the catalytic site of RmSDH. • RmSDH was expressed in Pichia. pastoris and biochemically characterized. • RmSDH has potential application in splitting D/L-serine.« less

Reticulate melanism in western painted turtles (Chrysemys picta bellii): Exploring linkages with habitat and heating rates

USGS Publications Warehouse

Gronke, W.K.; Chipps, S.R.; Bandas, S.J.; Higgins, K.F.

2006-01-01

In western painted turtles (Chrysemys picta bellii), males often exhibit one of two morphs: (1) a reticulated form, characterized by an intricate network of dark markings on the carapace or (2) a non-reticulated form. Although several hypotheses have been proposed to explain the adaptive significance of reticulate melanism (RM) on western painted turtles, no attempts have been made to document whether RM is linked to habitat conditions or if the presence of melanism affects heating rates. To evaluate these questions, we compared the frequency of adult male turtles with RM across three different habitats: riverine (rivers), lacustrine (lakes) and palustrine (wetland) habitats. Using manipulative experiments, we also tested the hypothesis that body heating rates are higher in turtles with RM. Reticulate melanism occurred on 99 (31%) of 320 male turtles captured in South Dakota from 2002 to 2003. Turtles with reticulate melanism were significantly larger than non-reticulated turtles; RM was not observed on male turtles with carapace lengths 15 cm carapace length) with RM was similar among river (0.54), lake (0.50) and wetland (0.64) habitats, implying that RM is not a habitat-linked trait. Heating rates for turtles with RM were similar to those measured for non-reticulated individuals. Body size, however, influenced heating rates; larger-bodied turtles with lower surface area-to-volume ratio heated more slowly than smaller turtles. Whether RM is a by-product of hormonal regulation or serves an adaptive purpose remains unclear. However, other hypotheses, especially those involving communication (e.g., courtship behavior) and/or gamete protection remain untested for western painted turtles and warrant further investigation.

Relationships between Mechanical Variables in the Traditional and Close-Grip Bench Press.

PubMed

Lockie, Robert G; Callaghan, Samuel J; Moreno, Matthew R; Risso, Fabrice G; Liu, Tricia M; Stage, Alyssa A; Birmingham-Babauta, Samantha A; Stokes, John J; Giuliano, Dominic V; Lazar, Adrina; Davis, DeShaun L; Orjalo, Ashley J

2017-12-01

The study aim was to determine relationships between mechanical variables in the one-repetition maximum (1RM) traditional bench press (TBP) and close-grip bench press (CGBP). Twenty resistance-trained men completed a TBP and CGBP 1RM. The TBP was performed with the preferred grip; the CGBP with a grip width of 95% biacromial distance. A linear position transducer measured: lift distance and duration; work; and peak and mean power, velocity, and force. Paired samples t-tests (p < 0.05) compared the 1RM and mechanical variables for the TBP and CGBP; effect sizes (d) were also calculated. Pearson's correlations (r; p < 0.05) computed relationships between the TBP and CGBP. 1RM, lift duration, and mean force were greater in the TBP (d = 0.30-3.20). Peak power and velocity was greater for the CGBP (d = 0.50-1.29). The 1RM TBP correlated with CGBP 1RM, power, and force (r = 0.685-0.982). TBP work correlated with CGBP 1RM, lift distance, power, force, and work (r = 0.542-0.931). TBP power correlated with CGBP 1RM, power, force, velocity, and work (r = 0.484-0.704). TBP peak and mean force related to CGBP 1RM, power, and force (r = 0.596-0.980). Due to relationships between the load, work, power, and force for the TBP and CGBP, the CGBP could provide similar strength adaptations to the TBP with long-term use. The velocity profile for the CGBP was different to that of the TBP. The CGBP could be used specifically to improve high-velocity, upper-body pushing movements.

Effect of processed and red meat on endogenous nitrosation and DNA damage.

PubMed

Joosen, Annemiek M C P; Kuhnle, Gunter G C; Aspinall, Sue M; Barrow, Timothy M; Lecommandeur, Emmanuelle; Azqueta, Amaya; Collins, Andrew R; Bingham, Sheila A

2009-08-01

Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) meat additionally contains high concentrations of preformed NOC. In two studies, of a fresh RM versus a vegetarian (VEG) diet (six males and six females) and of a nitrite-preserved red meat (PM) versus a VEG diet (5 males and 11 females), we investigated whether processing of meat might increase colorectal cancer risk by stimulating nitrosation and DNA damage. Meat diets contained 420 g (males) or 366 g (females) meat/per day. Faecal homogenates from day 10 onwards were analysed for haem and NOC and associated supernatants for genotoxicity. Means are adjusted for differences in male to female ratios between studies. Faecal NOC concentrations on VEG diets were low (2.6 and 3.5 mmol/g) but significantly higher on meat diets (PM 175 +/- 19 nmol/g versus RM 185 +/- 22 nmol/g; P = 0.75). The RM diet resulted in a larger proportion of nitrosyl iron (RM 78% versus PM 54%; P < 0.0001) and less nitrosothiols (RM 12% versus PM 19%; P < 0.01) and other NOC (RM 10% versus PM 27%; P < 0.0001). There was no statistically significant difference in DNA breaks induced by faecal water (FW) following PM and RM diets (P = 0.80). However, PM resulted in higher levels of oxidized pyrimidines (P < 0.05). Surprisingly, VEG diets resulted in significantly more FW-induced DNA strand breaks than the meat diets (P < 0.05), which needs to be clarified in further studies. Meats cured with nitrite have the same effect as fresh RM on endogenous nitrosation but show increased FW-induced oxidative DNA damage.

Oxidative stress/reactive metabolite gene expression signature in rat liver detects idiosyncratic hepatotoxicants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leone, Angelique; Nie, Alex; Brandon Parker, J.

Previously we reported a gene expression signature in rat liver for detecting a specific type of oxidative stress (OS) related to reactive metabolites (RM). High doses of the drugs disulfiram, ethinyl estradiol and nimesulide were used with another dozen paradigm OS/RM compounds, and three other drugs flutamide, phenacetin and sulindac were identified by this signature. In a second study, antiepileptic drugs were compared for covalent binding and their effects on OS/RM; felbamate, carbamazepine, and phenobarbital produced robust OS/RM gene expression. In the present study, liver RNA samples from drug-treated rats from more recent experiments were examined for statistical fit tomore » the OS/RM signature. Of all 97 drugs examined, in addition to the nine drugs noted above, 19 more were identified as OS/RM-producing compounds—chlorpromazine, clozapine, cyproterone acetate, dantrolene, dipyridamole, glibenclamide, isoniazid, ketoconazole, methapyrilene, naltrexone, nifedipine, sulfamethoxazole, tamoxifen, coumarin, ritonavir, amitriptyline, valproic acid, enalapril, and chloramphenicol. Importantly, all of the OS/RM drugs listed above have been linked to idiosyncratic hepatotoxicity, excepting chloramphenicol, which does not have a package label for hepatotoxicity, but does have a black box warning for idiosyncratic bone marrow suppression. Most of these drugs are not acutely toxic in the rat. The OS/RM signature should be useful to avoid idiosyncratic hepatotoxicity of drug candidates. - Highlights: • 28 of 97 drugs gave a positive OS/RM gene expression signature in rat liver. • The specificity of the signature for human idiosyncratic hepatotoxicants was 98%. • The sensitivity of the signature for human idiosyncratic hepatotoxicants was 75%. • The signature can help eliminate hepatotoxicants from drug development.« less

The development of a repetition-load scheme for the eccentric-only bench press exercise.

PubMed

Moir, Gavin L; Erny, Kyle F; Davis, Shala E; Guers, John J; Witmer, Chad A

2013-01-01

The purpose of the present study was to develop a repetition-load scheme for the eccentric-only bench press exercise. Nine resistance trained men (age: 21.6 ± 1.0 years; 1-repetition maximum [RM] bench press: 137.7 ± 30.4 kg) attended four testing sessions during a four week period. During the first session each subject's 1-RM bench press load utilizing the stretch-shortening cycle was determined. During the remaining sessions they performed eccentric-only repetitions to failure using supra-maximal loads equivalent to 110%, 120% and 130% of their 1-RM value with a constant cadence (30 reps·min(-1)). Force plates and a three dimensional motion analysis system were used during these final three sessions in order to evaluate kinematic and kinetic variables. More repetitions were completed during the 110% 1-RM condition compared to the 130% 1-RM condition (p=0.01). Mean total work (p=0.046) as well as vertical force (p=0.049), vertical work (p=0.017), and vertical power output (p=0.05) were significantly greater during the 130% 1-RM condition compared to the 110% 1-RM condition. A linear function was fitted to the number of repetitions completed under each load condition that allowed the determination of the maximum number of repetitions that could be completed under other supra-maximal loads. This linear function predicted an eccentric-only 1-RM in the bench press with a load equivalent to 164.8% 1-RM, producing a load of 227.0 ± 50.0 kg. The repetition-load scheme presented here should provide a starting point for researchers to investigate the kinematic, kinetic and metabolic responses to eccentric-only bench press workouts.

Genetic Dissection of Root Morphological Traits Related to Nitrogen Use Efficiency in Brassica napus L. under Two Contrasting Nitrogen Conditions

PubMed Central

Wang, Jie; Dun, Xiaoling; Shi, Jiaqin; Wang, Xinfa; Liu, Guihua; Wang, Hanzhong

2017-01-01

As the major determinant for nutrient uptake, root system architecture (RSA) has a massive impact on nitrogen use efficiency (NUE). However, little is known the molecular control of RSA as related to NUE in rapeseed. Here, a rapeseed recombinant inbred line population (BnaZNRIL) was used to investigate root morphology (RM, an important component for RSA) and NUE-related traits under high-nitrogen (HN) and low-nitrogen (LN) conditions by hydroponics. Data analysis suggested that RM-related traits, particularly root size had significantly phenotypic correlations with plant dry biomass and N uptake irrespective of N levels, but no or little correlation with N utilization efficiency (NUtE), providing the potential to identify QTLs with pleiotropy or specificity for RM- and NUE-related traits. A total of 129 QTLs (including 23 stable QTLs, which were repeatedly detected at least two environments or different N levels) were identified and 83 of them were integrated into 22 pleiotropic QTL clusters. Five RM-NUE, ten RM-specific and three NUE-specific QTL clusters with same directions of additive-effect implied two NUE-improving approaches (RM-based and N utilization-based directly) and provided valuable genomic regions for NUE improvement in rapeseed. Importantly, all of four major QTLs and most of stable QTLs (20 out of 23) detected here were related to RM traits under HN and/or LN levels, suggested that regulating RM to improve NUE would be more feasible than regulating N efficiency directly. These results provided the promising genomic regions for marker-assisted selection on RM-based NUE improvement in rapeseed. PMID:29033971

Relationships between Mechanical Variables in the Traditional and Close-Grip Bench Press

PubMed Central

Callaghan, Samuel J.; Moreno, Matthew R.; Risso, Fabrice G.; Liu, Tricia M.; Stage, Alyssa A.; Birmingham-Babauta, Samantha A.; Stokes, John J.; Giuliano, Dominic V.; Lazar, Adrina; Davis, DeShaun L.; Orjalo, Ashley J.

2017-01-01

Abstract The study aim was to determine relationships between mechanical variables in the one-repetition maximum (1RM) traditional bench press (TBP) and close-grip bench press (CGBP). Twenty resistance-trained men completed a TBP and CGBP 1RM. The TBP was performed with the preferred grip; the CGBP with a grip width of 95% biacromial distance. A linear position transducer measured: lift distance and duration; work; and peak and mean power, velocity, and force. Paired samples t-tests (p < 0.05) compared the 1RM and mechanical variables for the TBP and CGBP; effect sizes (d) were also calculated. Pearson’s correlations (r; p < 0.05) computed relationships between the TBP and CGBP. 1RM, lift duration, and mean force were greater in the TBP (d = 0.30-3.20). Peak power and velocity was greater for the CGBP (d = 0.50-1.29). The 1RM TBP correlated with CGBP 1RM, power, and force (r = 0.685-0.982). TBP work correlated with CGBP 1RM, lift distance, power, force, and work (r = 0.542-0.931). TBP power correlated with CGBP 1RM, power, force, velocity, and work (r = 0.484-0.704). TBP peak and mean force related to CGBP 1RM, power, and force (r = 0.596-0.980). Due to relationships between the load, work, power, and force for the TBP and CGBP, the CGBP could provide similar strength adaptations to the TBP with long-term use. The velocity profile for the CGBP was different to that of the TBP. The CGBP could be used specifically to improve high-velocity, upper-body pushing movements. PMID:29339982

The Development of a Repetition-Load Scheme for the Eccentric-Only Bench Press Exercise

PubMed Central

Moir, Gavin L.; Erny, Kyle F.; Davis, Shala E.; Guers, John J.; Witmer, Chad A.

2013-01-01

The purpose of the present study was to develop a repetition-load scheme for the eccentric-only bench press exercise. Nine resistance trained men (age: 21.6 ± 1.0 years; 1-repetition maximum [RM] bench press: 137.7 ± 30.4 kg) attended four testing sessions during a four week period. During the first session each subject’s 1-RM bench press load utilizing the stretch-shortening cycle was determined. During the remaining sessions they performed eccentric-only repetitions to failure using supra-maximal loads equivalent to 110%, 120% and 130% of their 1-RM value with a constant cadence (30 reps·min−1). Force plates and a three dimensional motion analysis system were used during these final three sessions in order to evaluate kinematic and kinetic variables. More repetitions were completed during the 110% 1-RM condition compared to the 130% 1-RM condition (p=0.01). Mean total work (p=0.046) as well as vertical force (p=0.049), vertical work (p=0.017), and vertical power output (p=0.05) were significantly greater during the 130% 1-RM condition compared to the 110% 1-RM condition. A linear function was fitted to the number of repetitions completed under each load condition that allowed the determination of the maximum number of repetitions that could be completed under other supra-maximal loads. This linear function predicted an eccentric-only 1-RM in the bench press with a load equivalent to 164.8% 1-RM, producing a load of 227.0 ± 50.0 kg. The repetition-load scheme presented here should provide a starting point for researchers to investigate the kinematic, kinetic and metabolic responses to eccentric-only bench press workouts. PMID:24235981

In vitro characterization of the effects of rat/mouse hemokinin-1 on mouse colonic contractile activity: a comparison with substance P.

PubMed

Kong, Zi-Qing; Han, Min; Yang, Wen-Le; Zhao, You-Li; Fu, Cai-Yun; Tao, Yan; Chen, Qiang; Wang, Rui

2009-06-01

Rat/mouse hemokinin-1 (r/m HK-1) has been identified as a member of the tachykinin family and its effect in colonic contractile activity remains unknown. We investigated the effects and mechanisms of actions of r/m HK-1 on the mouse colonic contractile activity in vitro by comparing it with that of substance P (SP). R/m HK-1 induced substantial contractions on the circular muscle of mouse colon. The maximal contractile responses to r/m HK-1 varied significantly among proximal-, mid- and distal-colon, suggesting that the action of r/m HK-1 was region-specific in mouse colon. The contractile response induced by r/m HK-1 is primarily via activation of tachykinin NK(1) receptors leading to activation of cholinergic excitatory pathways and with a minor contribution of NK(2) receptors, which may be on the smooth muscle itself. A direct action on colonic smooth muscles may be also involved. In contrast, SP induced biphasic colonic responses (contractile and relaxant responses) on the circular muscle, in which the contractile action of SP was equieffective with r/m HK-1. SP exerted its contractile effect predominantly through neural and muscular tachykinin NK(1) receptors, but unlike r/m HK-1 did not appear to act via NK(2) receptors. The relaxation induced by SP was largely due to release of nitric oxide (NO) produced via an action on neural NK(1) receptors. These results indicate that the receptors and the activation properties involved in r/m HK-1-induced mouse colonic contractile activity are different from those of SP.

Estimations of One Repetition Maximum and Isometric Peak Torque in Knee Extension Based on the Relationship Between Force and Velocity.

PubMed

Sugiura, Yoshito; Hatanaka, Yasuhiko; Arai, Tomoaki; Sakurai, Hiroaki; Kanada, Yoshikiyo

2016-04-01

We aimed to investigate whether a linear regression formula based on the relationship between joint torque and angular velocity measured using a high-speed video camera and image measurement software is effective for estimating 1 repetition maximum (1RM) and isometric peak torque in knee extension. Subjects comprised 20 healthy men (mean ± SD; age, 27.4 ± 4.9 years; height, 170.3 ± 4.4 cm; and body weight, 66.1 ± 10.9 kg). The exercise load ranged from 40% to 150% 1RM. Peak angular velocity (PAV) and peak torque were used to estimate 1RM and isometric peak torque. To elucidate the relationship between force and velocity in knee extension, the relationship between the relative proportion of 1RM (% 1RM) and PAV was examined using simple regression analysis. The concordance rate between the estimated value and actual measurement of 1RM and isometric peak torque was examined using intraclass correlation coefficients (ICCs). Reliability of the regression line of PAV and % 1RM was 0.95. The concordance rate between the actual measurement and estimated value of 1RM resulted in an ICC(2,1) of 0.93 and that of isometric peak torque had an ICC(2,1) of 0.87 and 0.86 for 6 and 3 levels of load, respectively. Our method for estimating 1RM was effective for decreasing the measurement time and reducing patients' burden. Additionally, isometric peak torque can be estimated using 3 levels of load, as we obtained the same results as those reported previously. We plan to expand the range of subjects and examine the generalizability of our results.

Parental Restriction of Mature-rated Media and Its Association with Substance Use among Argentinian Adolescents

PubMed Central

Mejia, Raul; Pérez, Adriana; Peña, Lorena; Morello, Paola; Kollath-Cattano, Christy; Braun, Sandra; Thrashe, James F.; Sargent, James D.

2016-01-01

Objective To assess the independent relation between parental restrictions on mature-rated media (M-RM) and substance use among South American adolescents. Methods Cross-sectional school-based youth survey of n=3,172 students (mean age 12.8 years; 57.6% boys) in three large Argentinian cities. The anonymous survey queried tobacco, alcohol, and drug use using items adapted from global youth surveys. Adolescents reported M-RM restriction for internet and videogames use, television programming and movies rated for adults. Multivariate logistic regression models assessed the association between parental M-RM restriction and substance use after adjusting for hourly media use, measures of authoritative parenting style, sociodemographics, and sensation seeking. Results Substance use rates were 10% for current smoking, 32% for current drinking alcohol, 17% for past 30-day binge drinking, and 8% for illicit drug use (marijuana or cocaine). Half of respondents reported parental M-RM restriction (internet 52%, TV 43%, adult movies 34%, videogame 25%). Parental M-RM restriction was only modestly correlated with authoritative parenting measures. In multivariate analyses M-RM restriction on all four venues was strongly protective for all substance use outcomes. Compared with no restriction, odds ratios for substance use for full restrictions were 0.32 (0.18–0.59), 0.53 (0.38–0.07), 0.36 (0.22–0.59), and 0.49 (0.26–0.92) for current smoking, drinking, binge drinking, and illicit drug use respectively. The most important single M-RM venue was movies. Conclusion This study confirms the protective association between parental M-RM restriction during adolescence and multiple substance use outcomes, including illicit drugs. M-RM restriction is independent of traditional parenting measures. The preponderance of the evidence supports intervention development. PMID:26615087

Evolution of shuttle avionics redundancy management/fault tolerance

NASA Technical Reports Server (NTRS)

Boykin, J. C.; Thibodeau, J. R.; Schneider, H. E.

1985-01-01

The challenge of providing redundancy management (RM) and fault tolerance to meet the Shuttle Program requirements of fail operational/fail safe for the avionics systems was complicated by the critical program constraints of weight, cost, and schedule. The basic and sometimes false effectivity of less than pure RM designs is addressed. Evolution of the multiple input selection filter (the heart of the RM function) is discussed with emphasis on the subtle interactions of the flight control system that were found to be potentially catastrophic. Several other general RM development problems are discussed, with particular emphasis on the inertial measurement unit RM, indicative of the complexity of managing that three string system and its critical interfaces with the guidance and control systems.

Using the load-velocity relationship for 1RM prediction.

PubMed

Jidovtseff, Boris; Harris, Nigel K; Crielaard, Jean-Michel; Cronin, John B

2011-01-01

The purpose of this study was to investigate the ability of the load-velocity relationship to accurately predict a bench press 1 repetition maximum (1RM). Data from 3 different bench press studies (n = 112) that incorporated both 1RM assessment and submaximal load-velocity profiling were analyzed. Individual regression analysis was performed to determine the theoretical load at zero velocity (LD0). Data from each of the 3 studies were analyzed separately and also presented as overall group mean. Thereafter, correlation analysis provided quantification of the relationships between 1RM and LD0. Practically perfect correlations (r = ∼0.95) were observed in our samples, confirming the ability of the load-velocity profile to accurately predict bench press 1RM.

"We as Human Beings Get Farther and Farther Apart": the experiences of patients with remote monitoring systems.

PubMed

Ottenberg, Abigale L; Swetz, Keith M; Mueller, Luke A; Gerhardson, Samantha; Mueller, Paul S

2013-01-01

To explore the experiences of patients living with an implantable cardioverter-defibrillator (ICD) who had received remote monitoring (RM). Anecdotal evidence suggests that not all patients with RM use the technology. Focus groups of patients with an ICD who received an RM system. Transcripts reviewed using thematic analysis. Nine patients (3 women and 6 men; median [range] age, 73 [58-91] years) received an RM system. Patients were assigned to a group in regard to RM system use (nonusers, n = 5; users, n = 4). Few nonusers recalled having prior conversations about the system. Users described it as "simple" and "easy" to use. Nonusers often were unsure whether their system was correctly transmitting information. System benefits perceived by users included convenience and security. Nonusers expressed mistrust. Recommendations included early education and help lines. Patient adherence to RM systems can be improved by explaining perceived benefits and addressing barriers to use. Copyright © 2013 Elsevier Inc. All rights reserved.

Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia.

PubMed

Gonzales, C; Leiva-Revilla, J; Rubio, J; Gasco, M; Gonzales, G F

2012-05-01

Lepidium meyenii (maca) is a plant that grows exclusively above 4000 m in the Peruvian central Andes. Red maca (RM) extract significantly reduced prostate size in rats with benign prostatic hyperplasia (BPH) induced by testosterone enanthate (TE). Zinc is an important regulator of prostate function. This study aimed to determine the effect of RM on prostate zinc levels in rats with BPH induced by TE. Also, the study attempted to determine the best marker for the effect of RM on sex accessory glands. Rats treated with RM extract from day 1 to day 14 reversed the effect of TE administration on prostate weight and zinc levels. However, RM administered from day 7 to day 14 did not reduce the effect of TE on all studied variables. Finasteride (FN) reduced prostate, seminal vesicle and preputial gland weights in rats treated with TE. Although RM and FN reduced prostate zinc levels, the greatest effect was observed in TE-treated rats with RM from day 1 to day 14. In addition, prostate weight and zinc levels showed the higher diagnosis values than preputial and seminal vesicle weights. In conclusion, RM administered from day 1 to day 14 reduced prostate size and zinc levels in rats where prostatic hyperplasia was induced with TE. Also, this experimental model could be used as accurately assay to determine the effect of maca obtained under different conditions and/or the effect of different products based on maca. © 2011 Blackwell Verlag GmbH.

Light in condensed matter in the upper atmosphere as the origin of homochirality: circularly polarized light from Rydberg matter.

PubMed

Holmlid, Leif

2009-01-01

Clouds of the condensed excited Rydberg matter (RM) exist in the atmospheres of comets and planetary bodies (most easily observed at Mercury and the Moon), where they surround the entire bodies. Vast such clouds are recently proposed to exist in the upper atmosphere of Earth (giving rise to the enormous features called noctilucent clouds, polar mesospheric clouds, and polar mesospheric summer radar echoes). It has been shown in experiments with RM that linearly polarized visible light scattered from an RM layer is transformed to circularly polarized light with a probability of approximately 50%. The circular Rydberg electrons in the magnetic field in the RM may be chiral scatterers. The magnetic and anisotropic RM medium acts as a circular polarizer probably by delaying one of the perpendicular components of the light wave. The delay process involved is called Rabi-flopping and gives delays of the order of femtoseconds. This strong effect thus gives intense circularly polarized visible and UV light within RM clouds. Amino acids and other chiral molecules will experience a strong interaction with this light field in the upper atmospheres of planets. The interaction will vary with the stereogenic conformation of the molecules and in all probability promote the survival of one enantiomer. Here, this strong effect is proposed to be the origin of homochirality. The formation of amino acids in the RM clouds is probably facilitated by the catalytic effect of RM.

Light in Condensed Matter in the Upper Atmosphere as the Origin of Homochirality: Circularly Polarized Light from Rydberg Matter

NASA Astrophysics Data System (ADS)

Holmlid, Leif

2009-08-01

Clouds of the condensed excited Rydberg matter (RM) exist in the atmospheres of comets and planetary bodies (most easily observed at Mercury and the Moon), where they surround the entire bodies. Vast such clouds are recently proposed to exist in the upper atmosphere of Earth (giving rise to the enormous features called noctilucent clouds, polar mesospheric clouds, and polar mesospheric summer radar echoes). It has been shown in experiments with RM that linearly polarized visible light scattered from an RM layer is transformed to circularly polarized light with a probability of approximately 50%. The circular Rydberg electrons in the magnetic field in the RM may be chiral scatterers. The magnetic and anisotropic RM medium acts as a circular polarizer probably by delaying one of the perpendicular components of the light wave. The delay process involved is called Rabi-flopping and gives delays of the order of femtoseconds. This strong effect thus gives intense circularly polarized visible and UV light within RM clouds. Amino acids and other chiral molecules will experience a strong interaction with this light field in the upper atmospheres of planets. The interaction will vary with the stereogenic conformation of the molecules and in all probability promote the survival of one enantiomer. Here, this strong effect is proposed to be the origin of homochirality. The formation of amino acids in the RM clouds is probably facilitated by the catalytic effect of RM.

Immunodetection of the Bacteriocin Lacticin RM: Analysis of the Influence of Temperature and Tween 80 on Its Expression and Activity

PubMed Central

Keren, Tomer; Yarmus, Merav; Halevy, Galia; Shapira, Roni

2004-01-01

Immunoassays with specific antibodies offer higher sensitivity than do bioassays with indicator strains in the detection and quantification of several bacteriocins. Here we present the purification of lacticin RM and the production of specific polyclonal antibodies to a synthetic peptide resembling an internal fragment of the mature bacteriocin. The specificity and sensitivity of the generated polyclonal antibodies were evaluated in various immunoassays. The detection limits of lacticin RM were found to be 1.9, 0.16, and 0.18 μg ml−1 for Western blot, immuno-dot blot, and noncompetitive indirect enzyme-linked immunosorbent assays, respectively. Immunoassay sensitivities were 12.5-fold higher than that of the agar diffusion test (ADT). The production of lacticin RM showed temperature dependency, with 3, 4.2, 12.7, 28.9, 37.8, and 12 μg ml−1 at 37, 30, 20, 15, 10, and 4°C, respectively. Temperature-stability analysis demonstrated that lacticin RM is sensitive to mild temperature, but the loss of activity does not seem to result from protein degradation. Tween 80 increased the concentration of lacticin RM eightfold and probably affected the results of the ADT either by enhancing the activity of lacticin RM or by increasing the sensitivity of the indicator strain. The use of antibodies for the specific detection and quantification of lacticin RM can expand our knowledge of its production and stability, with important implications for further investigation and future application. PMID:15066801

Influence of Drought on Mesophyll Resistance to CO2 Diffusion and its Impact on Water-Use Efficiency in Trees

NASA Astrophysics Data System (ADS)

Guo, J.; Beverly, D.; Cook, C.; Ewers, B. E.; Williams, D. G.

2015-12-01

The resistance to CO2 diffusion inside leaves (mesophyll resistance; rm) during photosynthesis is often comparable in magnitude to stomatal diffusion resistance, and varies among species and across environmental conditions. Consequently, photosynthesis is strongly limited by rm at low internal CO2 partial pressures, such that its variation may determine patterns of leaf water-use efficiency (WUE). Reduction in stomatal conductance with drought typically increases WUE, but also decreases photosynthesis. In theory, the decrease in photosynthesis could be countered by reduction in rm while maintaining high WUE. It is still uncertain how drought-related changes in rm affect short- and long-term WUE strategies of different tree species. We conducted field observations of instantaneous WUE and 13C discrimination in two dominant conifer species (Pinus contorta and Picea engelmannii) in SE Wyoming over the seasonal dry-down period in the summer of 2015. rm was examined by on-line 13C discrimination using isotope laser spectroscopy. Controlled environment studies on three conifer species (P. contorta, P. engelmannii, and Abies lasiocarpa) and one angiosperm (Populus tremuloides) are in progress. We hypothesize that the plasticity of rm in response to drought accounts for significant adjustments in photosynthetic capacity and WUE. Needle leaf conifers are known to have relatively high rm, and we expect them to show greater improvements in photosynthesis and WUE when rm is decreased compared to angiosperm tree species.

Grain Oriented Perovskite Layer Structure Ceramics for High-Temperature Piezoelectric Applications

NASA Astrophysics Data System (ADS)

Fuierer, Paul Anton

The perovskite layer structure (PLS) compounds have the general formula (A^{2+}) _2(B^{5+})_2 O_7, or (A^ {3+})_2(B^{4+ })_2O_7, and crystallize in a very anisotropic layered structure consisting of parallel slabs made up of perovskite units. Several of these compounds possess the highest Curie temperatures (T_{rm c} ) of any known ferroelectrics. Two examples are Sr_2Nb_2O _7 with T_{rm c} of 1342^circC, and La_2Ti_2O _7 with T_{rm c} of 1500^circC. This thesis is an investigation of PLS ceramics and their feasibility as a high temperature transducer material. Piezoelectricity in single crystals has been measured, but the containerless float zone apparatus necessary to grow high quality crystals of these refractory compounds is expensive and limited to a small number of research groups. Previous attempts to pole polycrystalline Sr_2Nb _2O_7 have failed, and to this point piezoelectricity has been absent. The initiative taken in this research was to investigate PLS ceramics by way of composition and processing schemes such that polycrystalline bodies could be electrically poled. The ultimate objective then was to demonstrate piezoelectricity in PLS ceramics, especially at high temperatures. Donor-doping of both La_2Ti _2O_7 and Sr_2Nb_2O _7 was found to increase volume resistivities at elevated temperatures, an important parameter to consider during the poling process. Sr_2Ta _2O_7 (T _{rm c} = -107 ^circC) was used to make solid solution compositions with moderately high Curie temperatures, of about 850^circC, and lower coercive fields. A hot-forging technique was employed to produce ceramics with high density (>99% of theoretical) and high degree of grain orientation (>90%). Texturing was characterized by x-ray diffraction and microscopy. Considerable anisotropy was observed in physical and electrical properties, including thermal expansion, resistivity, dielectric constant, and polarization. The direction perpendicular to the forging axis proved to be the ferroelectric "easy" direction, indicating that the polar axis lies in the plane of the plate-like grains. Hot-forged samples were poled at 40 to 50 KV/cm at 200^circC. Several compounds in the La_2Ti_2O _7-Sr_2Nb _2O_7-Sr _2Ta_2O_7 ternary system were shown to be piezoelectric. From appropriately oriented cuts, the dielectric, elastic, and piezoelectric coefficients were determined by the resonance method. Relative to commercial piezoelectric ceramics such as Pb(ZrTi)O_3, hot-forged PLS ceramics were found to have high frequency constants, low compliance, low electromechanical coupling, low piezoelectric coefficients, and high mechanical quality factors. For Sr_2(Nb_{0.5 }Ta_{0.5})_2 O_7, N_{32 } = 2216 Hz-m, s_{32} = 8.37 times 10^ {-12} m^2/N, k _{32} = 3.60%, d _{32} = 2.40 pC/N, and Q _{rm m} = 5290. This material was also shown to resist depoling when exposed to temperatures as high as 650^circC. Hot-forged PLS compounds offer a new family of ferroelectric ceramics that may prove to be useful as high temperature materials for electronic transducers or filters.

Materials Research Society Symposium Proceedings Held in Boston, Massachusetts on 4-6 December 1991. Low Temperature (LT) GaAs and Related Materials. Volume 241.

DTIC Science & Technology

1992-09-14

AIGaAs-GaAs QUANTUM WELLS GROWN ON LOW TEMPERATURE GaAs 239 Y. Hwang, D. Zhang, T. Zhang, M. Mytych, and R.M. Kolbas MOLECULAR BEAM EPITAXY OF LOW...GaA/ quantum wells : 24i howvever, in our case. AIks layers were not introduced. Formation (if these rows is most prolf,.+l influenced hb the diffusimon...regions. Preliminary investigations into this method have been performed using GaAs quantum wells between thick AIGaAs barriers as shown in Fig. 7. This

Reliability of Maximal Strength Testing in Novice Weightlifters

NASA Technical Reports Server (NTRS)

Loehr, James A.; Lee, Stuart M. C.; Feiveson, Alan H.; Ploutz-Snyder, Lori L.

2009-01-01

The one repetition maximum (1RM) is a criterion measure of muscle strength. However, the reliability of 1RM testing in novice subjects has received little attention. Understanding this information is crucial to accurately interpret changes in muscle strength. To evaluate the test-retest reliability of a squat (SQ), heel raise (HR), and deadlift (DL) 1RM in novice subjects. Twenty healthy males (31 plus or minus 5 y, 179.1 plus or minus 6.1 cm, 81.4 plus or minus 10.6 kg) with no weight training experience in the previous six months participated in four 1RM testing sessions, with each session separated by 5-7 days. SQ and HR 1RM were conducted using a smith machine; DL 1RM was assessed using free weights. Session 1 was considered a familiarization and was not included in the statistical analyses. Repeated measures analysis of variance with Tukey fs post-hoc tests were used to detect between-session differences in 1RM (p.0.05). Test-retest reliability was evaluated by intraclass correlation coefficients (ICC). During Session 2, the SQ and DL 1RM (SQ: 90.2 }4.3, DL: 75.9 }3.3 kg) were less than Session 3 (SQ: 95.3 }4.1, DL: 81.5 plus or minus 3.5 kg) and Session 4 (SQ: 96.6 }4.0, DL: 82.4 }3.9 kg), but there were no differences between Session 3 and Session 4. HR 1RM measured during Session 2 (150.1 }3.7 kg) and Session 3 (152.5 }3.9 kg) were not different from one another, but both were less than Session 4 (157.5 }3.8 kg). The reliability (ICC) of 1RM measures for Sessions 2-4 were 0.88, 0.83, and 0.87, for SQ, HR, and DL, respectively. When considering only Sessions 3 and 4, the reliability was 0.93, 0.91, and 0.86 for SQ, HR, and DL, respectively. One familiarization session and 2 test sessions (for SQ and DL) were required to obtain excellent reliability (ICC greater than or equal to 0.90) in 1RM values with novice subjects. We were unable to attain this level of reliability following 3 HR testing sessions therefore additional sessions may be required to obtain an ICC of greater than or equal to 0.90. Future resistive exercise studies should consider the reliability of specific measures to ensure that changes in strength with training are attributable to training and not learning effects associated with 1RM testing.

Comparison of Predicted and Measured Towline Tensions

DTIC Science & Technology

1994-05-01

10 volts DC Calibration Error Less than 0.25% of full capacity Material Stainless Steel The installed configuration of the load cell at the tow end is...capacity zero shift per IF over operating temperature range. Construction- Stainless steel , seal welded. Electrical Connector- Brantner MSJ-4-BCR...Manufacturer- Marsh & MarineTm Connectors 150 Manufacturer’s Part #- RM-4-MP Description- Molded in-line female connector with stainless steel

What Works in Gifted Education Mathematics Study: Impact of Pre-Differentiated and Enriched Curricula on General Education Teachers and Their Students. Research Monograph Series. RM13242

ERIC Educational Resources Information Center

Gubbins, E. Jean; McCoach, D. Betsy; Foreman, Jennifer L.; Gilson, Cindy M.; Bruce-Davis, Micah N.; Rubenstein, Lisa DaVia; Savino, Jennifer; Rambo, Karen; Waterman, Craig

2013-01-01

The present study seeks to determine how exposure to pre-differentiated and enriched curricula incorporating educative curriculum materials affects students' achievement as well as teacher and administrator responses to the intervention. A 2-year multi-site cluster randomized control trial study recruited a national sample of 4,530 grade 3…

Using Growth and Arrest of Richtmyer-Meshkov Instabilities and Lagrangian Simulations to Study High-Rate Material Strength

NASA Astrophysics Data System (ADS)

Prime, Michael; Vaughan, Diane; Preston, Dean; Oro, David; Buttler, William

2013-06-01

Rayleigh-Taylor instabilities have been widely used to study the deviatoric (flow) strength of solids at high strain rates. More recently, experiments applying a supported shock through mating surfaces (Atwood number = 1) with geometrical perturbations have been proposed for studying strength at strain rates up to 107/sec using Richtmyer-Meshkov (RM) instabilities. Buttler et al. [J. Fluid Mech., 2012] recently reported experimental results for RM instability growth but with an unsupported shock applied by high explosives and the geometrical perturbations on the opposite free surface (Atwood number = -1). This novel configuration allowed detailed experimental observation of the instability growth and arrest. We present results and detailed interpretation from numerical simulations of the Buttler experiments on copper. Highly-resolved, two-dimensional simulations were performed using a Lagrangian hydrocode and the Preston-Tonks-Wallace (PTW) strength model. The model predictions show good agreement with the data in spite of the PTW model being calibrated on lower strain rate data. The numerical simulations are used to 1) examine various assumptions previously made in an analytical model, 2) to estimate the sensitivity of such experiments to material strength and 3) to explore the possibility of extracting meaningful strength information in the face of complicated spatial and temporal variations of stress, pressure, and temperature during the experiments.

A New Cuffless Device for Measuring Blood Pressure: A Real-Life Validation Study.

PubMed

Schoot, Tessa S; Weenk, Mariska; van de Belt, Tom H; Engelen, Lucien J L P G; van Goor, Harry; Bredie, Sebastian J H

2016-05-05

Cuffless blood pressure (BP) monitoring devices, based on pulse transit time, are being developed as an easy-to-use, more convenient, fast, and relatively cheap alternative to conventional BP measuring devices based on cuff occlusion. Thereby they may provide a great alternative to BP self-measurement. The objective of our study was to evaluate the performance of the first release of the Checkme Health Monitor (Viatom Technology), a cuffless BP monitor, in a real-life setting. Furthermore, we wanted to investigate whether the posture of the volunteer and the position of the device relative to the heart level would influence its outcomes. Study volunteers fell into 3 BP ranges: high (>160 mmHg), normal (130-160 mmHg), and low (<130 mmHg). All requirements for test environment, observer qualification, volunteer recruitment, and BP measurements were met according to the European Society of Hypertension International Protocol (ESH-IP) for the validation of BP measurement devices. After calibrating the Checkme device, we measured systolic BP with Checkme and a validated, oscillometric reference BP monitor (RM). Measurements were performed in randomized order both in supine and in sitting position, and with Checkme at and above heart level. We recruited 52 volunteers, of whom we excluded 15 (12 due to calibration failure with Checkme, 3 due to a variety of reasons). The remaining 37 volunteers were divided into low (n=14), medium (n=13), and high (n=10) BP ranges. There were 18 men and 19 women, with a mean age of 54.1 (SD 14.5) years, and mean recruitment systolic BP of 141.7 (SD 24.7) mmHg. BP results obtained by RM and Checkme correlated well. In the supine position, the difference between the RM and Checkme was >5 mmHg in 17 of 37 volunteers (46%), of whom 9 of 37 (24%) had a difference >10 mmHg and 5 of 37 (14%) had a difference >15 mmHg. BP obtained with Checkme correlated well with RM BP, particularly in the position (supine) in which the device was calibrated. These preliminary results are promising for conducting further research on cuffless BP measurement in the clinical and outpatient settings.

What is the best method to fit time-resolved data? A comparison of the residual minimization and the maximum likelihood techniques as applied to experimental time-correlated, single-photon counting data

DOE PAGES

Santra, Kalyan; Zhan, Jinchun; Song, Xueyu; ...

2016-02-10

The need for measuring fluorescence lifetimes of species in subdiffraction-limited volumes in, for example, stimulated emission depletion (STED) microscopy, entails the dual challenge of probing a small number of fluorophores and fitting the concomitant sparse data set to the appropriate excited-state decay function. This need has stimulated a further investigation into the relative merits of two fitting techniques commonly referred to as “residual minimization” (RM) and “maximum likelihood” (ML). Fluorescence decays of the well-characterized standard, rose bengal in methanol at room temperature (530 ± 10 ps), were acquired in a set of five experiments in which the total number ofmore » “photon counts” was approximately 20, 200, 1000, 3000, and 6000 and there were about 2–200 counts at the maxima of the respective decays. Each set of experiments was repeated 50 times to generate the appropriate statistics. Each of the 250 data sets was analyzed by ML and two different RM methods (differing in the weighting of residuals) using in-house routines and compared with a frequently used commercial RM routine. Convolution with a real instrument response function was always included in the fitting. While RM using Pearson’s weighting of residuals can recover the correct mean result with a total number of counts of 1000 or more, ML distinguishes itself by yielding, in all cases, the same mean lifetime within 2% of the accepted value. For 200 total counts and greater, ML always provides a standard deviation of <10% of the mean lifetime, and even at 20 total counts there is only 20% error in the mean lifetime. Here, the robustness of ML advocates its use for sparse data sets such as those acquired in some subdiffraction-limited microscopies, such as STED, and, more importantly, provides greater motivation for exploiting the time-resolved capacities of this technique to acquire and analyze fluorescence lifetime data.« less

Archetype-based conversion of EHR content models: pilot experience with a regional EHR system.

PubMed

Chen, Rong; Klein, Gunnar O; Sundvall, Erik; Karlsson, Daniel; Ahlfeldt, Hans

2009-07-01

Exchange of Electronic Health Record (EHR) data between systems from different suppliers is a major challenge. EHR communication based on archetype methodology has been developed by openEHR and CEN/ISO. The experience of using archetypes in deployed EHR systems is quite limited today. Currently deployed EHR systems with large user bases have their own proprietary way of representing clinical content using various models. This study was designed to investigate the feasibility of representing EHR content models from a regional EHR system as openEHR archetypes and inversely to convert archetypes to the proprietary format. The openEHR EHR Reference Model (RM) and Archetype Model (AM) specifications were used. The template model of the Cambio COSMIC, a regional EHR product from Sweden, was analyzed and compared to the openEHR RM and AM. This study was focused on the convertibility of the EHR semantic models. A semantic mapping between the openEHR RM/AM and the COSMIC template model was produced and used as the basis for developing prototype software that performs automated bi-directional conversion between openEHR archetypes and COSMIC templates. Automated bi-directional conversion between openEHR archetype format and COSMIC template format has been achieved. Several archetypes from the openEHR Clinical Knowledge Repository have been imported into COSMIC, preserving most of the structural and terminology related constraints. COSMIC templates from a large regional installation were successfully converted into the openEHR archetype format. The conversion from the COSMIC templates into archetype format preserves nearly all structural and semantic definitions of the original content models. A strategy of gradually adding archetype support to legacy EHR systems was formulated in order to allow sharing of clinical content models defined using different formats. The openEHR RM and AM are expressive enough to represent the existing clinical content models from the template based EHR system tested and legacy content models can automatically be converted to archetype format for sharing of knowledge. With some limitations, internationally available archetypes could be converted to the legacy EHR models. Archetype support can be added to legacy EHR systems in an incremental way allowing a migration path to interoperability based on standards.

Probabilistic Risk Assessment for Bone Fracture - Bone Fracture Risk Module (BFxRM)

NASA Technical Reports Server (NTRS)

Licata, Angelo; Myers, Jerry G.; Lewandowski, Beth

2013-01-01

This presentation summarizes the concepts, development, and application of NASA's Bone Fracture Risk Module (BFxRM). The overview includes an assessmnet of strenghts and limitations of the BFxRM and proposes a numebr of discussion questions to the panel regarding future development avenues for this simulation system.

40 CFR 725.60 - Withdrawal of submission by the submitter.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., OPPT Document Control Office (DCO), EPA East Bldg., 1201 Constitution Ave., NW., Rm. 6428, Washington... Control Office (DCO), EPA East Bldg., 1201 Constitution Ave., NW., Rm. 6428, Washington, DC 20004. (ii... Document Control Office (DCO), EPA East Bldg., 1201 Constitution Ave., NW., Rm. 6428, Washington, DC 20004...

Effects of ΛΛ ‑ ΞN mixing in the decay of {}_{{\\rm{\\Lambda }}{\\rm{\\Lambda }}}{}^{6}{\\rm{H}}{\\rm{e}}

NASA Astrophysics Data System (ADS)

Maneu, J.; Parreño, A.; Ramos, A.

2018-05-01

A one-meson exchange model including the ground state of the pseudoscalar octet is used to describe the weak two-body interactions responsible for the decay of {}{{Λ }{{Λ }}}{}6{{H}}{{e}}. Strong interaction effects are taken into account by a microscopic study based on the solution of G-matrix and T-matrix equations for the initial and final interacting pairs respectively. Results for the decay induced by {{Λ }}{{Λ }}\\to {{Λ }}N({{Σ }}N) transitions are given.

Risk Management Interventions to Reduce Injuries and Maximize Economic Benefits in U.S. Mining.

PubMed

Griffin, Stephanie C; Bui, David P; Gowrisankaran, Gautam; Lutz, Eric A; He, Charles; Hu, Chengcheng; Burgess, Jefferey L

2018-03-01

Risk management (RM) is a cyclical process of identifying and ranking risks, implementing controls, and evaluating their effectiveness. This study aims to identify effective RM interventions in the U.S. mining industry. RM interventions were identified in four companies representing metal, aggregate, and coal mining sectors. Injury rates were determined using Mine Safety and Health Administration (MSHA) data and changes in injury rates identified through change point analysis. Program implementation costs and associated changes in injury costs were evaluated for select interventions. Six of 20 RM interventions were associated with a decline in all injuries and one with a reduction in lost-time injuries, all with a positive return on investment. Reductions in injuries and associated costs were observed following implementation of a limited number of specific RM interventions.

Differential cross sections for excitation of H 2 by low-energy electron impact

DOE PAGES

Hargreaves, Leigh R.; Bhari, S.; Adjari, B.; ...

2017-10-31

Experimental and theoretical differential cross sections (DCS) for the electron-impact excitation of molecular hydrogen to themore » $$B{}^{1}{{\\rm{\\Sigma }}}_{u}^{+}$$, $$c{}^{3}{{\\rm{\\Pi }}}_{u}$$, $$a{}^{3}{{\\rm{\\Sigma }}}_{g}^{+}$$, $$C{}^{1}{{\\rm{\\Pi }}}_{u}$$, and the $$E(F){}^{1}{{\\rm{\\Sigma }}}_{g}^{+}$$ states are presented at incident energies near to threshold. The experimental DCSs were taken at incident energies of 14, 15, 16 and 17.5 eV and for scattering angles from 10° to 130°. In conclusion, the theoretical DCSs are from the convergent close-coupling method which has recently successfully modeled differential electron scattering from H 2 when compared with available experiment at energies of 17.5 eV and above.« less

Differential cross sections for excitation of H 2 by low-energy electron impact

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hargreaves, Leigh R.; Bhari, S.; Adjari, B.

Experimental and theoretical differential cross sections (DCS) for the electron-impact excitation of molecular hydrogen to themore » $$B{}^{1}{{\\rm{\\Sigma }}}_{u}^{+}$$, $$c{}^{3}{{\\rm{\\Pi }}}_{u}$$, $$a{}^{3}{{\\rm{\\Sigma }}}_{g}^{+}$$, $$C{}^{1}{{\\rm{\\Pi }}}_{u}$$, and the $$E(F){}^{1}{{\\rm{\\Sigma }}}_{g}^{+}$$ states are presented at incident energies near to threshold. The experimental DCSs were taken at incident energies of 14, 15, 16 and 17.5 eV and for scattering angles from 10° to 130°. In conclusion, the theoretical DCSs are from the convergent close-coupling method which has recently successfully modeled differential electron scattering from H 2 when compared with available experiment at energies of 17.5 eV and above.« less

Vortex wakes of a flapping foil in a flowing soap film

NASA Astrophysics Data System (ADS)

Schnipper, Teis; Andersen, Anders; Bohr, Tomas

2008-11-01

We present an experimental study of an oscillating, symmetric foil in a vertically flowing soap film. By varying frequency and amplitude of the oscillation we explore and visualize a variety of wake structures, including von Kármán wake, reverse von Kármán wake, 2P wake, and 2P+2S wake. We characterize the transition from the von Kármán wake (drag) to the reverse von Kármán wake (thrust) and discuss the results in relation to fish swimming. We visualize the time evolution of the vortex shedding in detail, identify the origins of the vortices comprising the wake, and propose a simple model to account for the transition from von Kármán like wakes to more exotic wake structures.

Using the Inflection Points and Rates of Growth and Decay to Predict Levels of Solar Activity

NASA Technical Reports Server (NTRS)

Wilson, Robert M.; Hathaway, David H.

2008-01-01

The ascending and descending inflection points and rates of growth and decay at specific times during the sunspot cycle are examined as predictors for future activity. On average, the ascending inflection point occurs about 1-2 yr after sunspot minimum amplitude (Rm) and the descending inflection point occurs about 6-7 yr after Rm. The ascending inflection point and the inferred slope (including the 12-mo moving average (12-mma) of (Delta)R (the month-to-month change in the smoothed monthly mean sunspot number (R)) at the ascending inflection point provide strong indications as to the expected size of the ongoing cycle s sunspot maximum amplitude (RM), while the descending inflection point appears to provide an indication as to the expected length of the ongoing cycle. The value of the 12-mma of (Delta)R at elapsed time T = 27 mo past the epoch of RM (E(RM)) seems to provide a strong indication as to the expected size of Rm for the following cycle. The expected Rm for cycle 24 is 7.6 +/- 4.4 (the 90-percent prediction interval), occurring before September 2008. Evidence is also presented for secular rises in selected cycle-related parameters and for preferential grouping of sunspot cycles by amplitude and/or period.

Do service users with intellectual disabilities want to be involved in the risk management process? A thematic analysis.

PubMed

Kilcommons, Aoiffe M; Withers, Paul; Moreno-Lopez, Águeda

2012-09-01

Involving ID service users in risk decision making necessitates consideration of an individual's ability to assess the implications and associated risks and thus make an informed choice. This calls for research on service users' awareness and understanding of risk management (RM). Thirteen people in a residential ID service who were reviewed under the risk management process (RMP) participated in the research. Thematic analysis explored participants' knowledge and understanding of risk management to establish ability to make informed choice. Two main meta-themes (lack of awareness about RM and awareness about RM) and four meta-themes (extent of RM awareness, locus of control, compliance and empowerment) emerged. Nine of 13 participants demonstrated some knowledge and awareness of RM and wanted to contribute to the RMP, despite not being consulted about or given the opportunity to be involved in RM. The majority of service users in this sample had some awareness of the purpose of RM and could make partially informed decisions about whether they would like to be involved in the RMP. The findings highlight the need for professionals to actively attempt to involve ID service users in the management of their own risk. © 2012 Blackwell Publishing Ltd.

Mast Cell Proteases 6 and 7 Stimulate Angiogenesis by Inducing Endothelial Cells to Release Angiogenic Factors

PubMed Central

de Souza, Devandir Antonio; Borges, Antonio Carlos; Santana, Ana Carolina; Oliver, Constance; Jamur, Maria Célia

2015-01-01

Mast cell proteases are thought to be involved with tumor progression and neo-vascularization. However, their exact role is still unclear. The present study was undertaken to further elucidate the function of specific subtypes of recombinant mouse mast cell proteases (rmMCP-6 and 7) in neo-vascularization. SVEC4-10 cells were cultured on Geltrex® with either rmMCP-6 or 7 and tube formation was analyzed by fluorescence microscopy and scanning electron microscopy. Additionally, the capacity of these proteases to induce the release of angiogenic factors and pro and anti-angiogenic proteins was analyzed. Both rmMCP-6 and 7 were able to stimulate tube formation. Scanning electron microscopy showed that incubation with the proteases induced SVEC4-10 cells to invade the gel matrix. However, the expression and activity of metalloproteases were not altered by incubation with the mast cell proteases. Furthermore, rmMCP-6 and rmMCP-7 were able to induce the differential release of angiogenic factors from the SVEC4-10 cells. rmMCP-7 was more efficient in stimulating tube formation and release of angiogenic factors than rmMCP-6. These results suggest that the subtypes of proteases released by mast cells may influence endothelial cells during in vivo neo-vascularization. PMID:26633538

Evidence for Helical Magnetic fields in Kiloparsec-Scale AGN Jets and the Action of a Cosmic Battery

NASA Technical Reports Server (NTRS)

Gabuzda, D. C.; Christodoulou, D. M.; Contopulos, I.; Kazanas, D.

2012-01-01

A search for transverse kiloparsec-scale gradients in Faraday rotation-measure (RM) maps of extragalactic radio sources in the literature has yielded 6 AGNs displaying continuous, monotonic RM gradients across their jets, oriented roughly orthogonal to the local jet direction. The most natural interpretation of such transverse RM gradients is that they are caused by the systematic change in the line-of-sight components of helical magnetic fields associated with these jets. All the identified transverse RM gradients increase in the counterclockwise (CCW) direction on the sky relative to the centers of these AGNs. Taken together with the results of Contopoulos et al. who found evidence for a predominance of clockwise (CW) transverse RM gradients across parsec-scale (VLBI) jets, this provides new evidence for preferred orientations of RM gradients due to helical jet magnetic fields, with a reversal from CW in the inner jets to CCW farther from the centers of activity. This can be explained by the "Poynting-Robertson cosmic-battery" mechanism, which can generate helical magnetic fields with a. characteristic "twist," which are expelled with the jet outflows. If the Poynting-Robertson battery mechanism is not operating, an alternative mechanism must be identified, which is able to explain the 'predominance of CW /CCW RM gradients on parsec/kiloparsec scales.

Comparative analyses of animal-tracking data reveal ecological significance of endothermy in fishes

PubMed Central

Watanabe, Yuuki Y.; Goldman, Kenneth J.; Caselle, Jennifer E.; Chapman, Demian D.; Papastamatiou, Yannis P.

2015-01-01

Despite long evolutionary separations, several sharks and tunas share the ability to maintain slow-twitch, aerobic red muscle (RM) warmer than ambient water. Proximate causes of RM endothermy are well understood, but ultimate causes are unclear. Two advantages often proposed are thermal niche expansion and elevated cruising speeds. The thermal niche hypothesis is generally supported, because fishes with RM endothermy often exhibit greater tolerance to broad temperature ranges. In contrast, whether fishes with RM endothermy cruise faster, and achieve any ecological benefits from doing so, remains unclear. Here, we compiled data recorded by modern animal-tracking tools for a variety of free-swimming marine vertebrates. Using phylogenetically informed allometry, we show that both cruising speeds and maximum annual migration ranges of fishes with RM endothermy are 2–3 times greater than fishes without it, and comparable to nonfish endotherms (i.e., penguins and marine mammals). The estimated cost of transport of fishes with RM endothermy is twice that of fishes without it. We suggest that the high energetic cost of RM endothermy in fishes is offset by the benefit of elevated cruising speeds, which not only increase prey encounter rates, but also enable larger-scale annual migrations and potentially greater access to seasonally available resources. PMID:25902489

Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aad, G.

2014-11-04

This article presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy ofmore » $$\\sqrt{s}=7\\;{\\rm Te}{\\rm V}$$ and correspond to an integrated luminosity of $$4.6\\;{\\rm f}{{{\\rm b}}^{-1}}$$. The measurement is performed by reconstructing the boosted W or Z bosons in single jets. The reconstructed jet mass is used to identify the W and Z bosons, and a jet substructure method based on energy cluster information in the jet centre-of-mass frame is used to suppress the large multi-jet background. The cross-section for events with a hadronically decaying W or Z boson, with transverse momentum $${{p}_{{\\rm T}}}\\gt 320\\;{\\rm Ge}{\\rm V}$$ and pseudorapidity $$|\\eta |\\lt 1.9$$, is measured to be $${{\\sigma }_{W+Z}}=8.5\\pm 1.7$$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques.« less

Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice.

PubMed

Broussard, John I; Acion, Laura; De Jesús-Cortés, Héctor; Yin, Terry; Britt, Jeremiah K; Salas, Ramiro; Costa-Mattioli, Mauro; Robertson, Claudia; Pieper, Andrew A; Arciniegas, David B; Jorge, Ricardo

2018-01-01

Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour. We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group. We assessed the effects of smTBI and rmTBI using measures of motor performance (Rotarod Test [RT]), anxiety-like behaviour (Elevated Plus Maze [EPM] and Open Field [OF] tests), and spatial memory (Morris Water Maze [MWM]) within 12 days of the final injury. In separate groups of mice, astrocytosis and microglial activation were assessed 24 hours after the final injury using GFAP and IBA-1 immunohistochemistry. RmTBI impaired spatial memory in the MWM and increased anxiety-like behaviour in the EPM and OFT. In addition, rmTBI elevated GFAP and IBA-1 immunohistochemistry throughout the mouse brain. RmTBI produced astrocytosis and microglial activation, and elicited impaired spatial memory and anxiety-like behaviour. rmTBI produces acute cognitive and anxiety-like disturbances associated with inflammatory changes in brain regions involved in spatial memory and anxiety.

Red Marrow-Absorbed Dose for Non-Hodgkin Lymphoma Patients Treated with 177Lu-Lilotomab Satetraxetan, a Novel Anti-CD37 Antibody-Radionuclide Conjugate.

PubMed

Blakkisrud, Johan; Løndalen, Ayca; Dahle, Jostein; Turner, Simon; Holte, Harald; Kolstad, Arne; Stokke, Caroline

2017-01-01

Red marrow (RM) is often the primary organ at risk in radioimmunotherapy; irradiation of marrow may induce short- and long-term hematologic toxicity. 177 Lu-lilotomab satetraxetan is a novel anti-CD37 antibody-radionuclide conjugate currently in phase 1/2a. Two predosing regimens have been investigated, one with 40 mg of unlabeled lilotomab antibody (arm 1) and one without (arm 2). The aim of this work was to compare RM-absorbed doses for the two arms and to correlate absorbed doses with hematologic toxicity. Eight patients with relapsed CD37+ indolent B-cell non-Hodgkin lymphoma were included for RM dosimetry. Hybrid SPECT and CT images were used to estimate the activity concentration in the RM of L2-L4. Pharmacokinetic parameters were calculated after measurement of the 177 Lu-lilotomab satetraxetan concentration in blood samples. Adverse events were graded according to the Common Terminology Criteria for Adverse Events, version 4.0. The mean absorbed doses to RM were 0.9 mGy/MBq for arm 1 (lilotomab+) and 1.5 mGy/MBq for arm 2 (lilotomab-). There was a statistically significant difference between arms 1 and 2 (Student t test, P = 0.02). Total RM-absorbed doses ranged from 67 to 127 cGy in arm 1 and from 158 to 207 cGy in arm 2. For blood, the area under the curve was higher with lilotomab predosing than without (P = 0.001), whereas the volume of distribution and the clearance of 177 Lu-lilotomab satetraxetan was significantly lower (P = 0.01 and P = 0.03, respectively). Patients with grade 3/4 thrombocytopenia had received significantly higher radiation doses to RM than patients with grade 1/2 thrombocytopenia (P = 0.02). A surrogate, non-imaging-based, method underestimated the RM dose and did not show any correlation with toxicity. Predosing with lilotomab reduces the RM-absorbed dose for 177 Lu-lilotomab satetraxetan patients. The decrease in RM dose could be explained by the lower volume of distribution. Hematologic toxicity was more severe for patients receiving higher absorbed radiation doses, indicating that adverse events possibly can be predicted by the calculation of absorbed dose to RM from SPECT/CT images. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

[Therapeutic effect of rmIL-12 combined with G-CSF on acute radiation sickness produced by γ-ray irradiation in mice].

PubMed

Wang, Li; Zhai, Rui-Ren; Pang, Zhao-Xia; Zhang, Chao; Yu, Chang-Lin

2012-08-01

The aim of this study is to observe the therapeutic effect of recombinant murine interleukin 12 (rmIL-12) combining with granulocyte colony stimulating factor (G-CSF) on mice irradiated by γ-rays. 56 BALB/c mice were totally irradiated by 6.0 Gy of (60)Co γ-ray and randomly divided into irradiation control group, rmIL-12 treatment group, G-CSF treatment group and combination therapy (rmIL-12 plus G-CSF) group. rmIL-12 20 µg/kg was administrated intraperitoneally at 1 h following irradiation, and was administrated every 3 days after irradiation for 4 times in rmIL-12 treatment group. G-CSF 100 µg/kg was administrated subcutaneously the 2 h following irradiation for 14 d in G-CSF treatment group. The dose and method of rmIL-12 and G-CSF in combination therapy group were same as in rmIL-12 group and G-CSF group. The general status of mice were observed twice a day, the changes in body weight, peripheral blood cell (WBC and Plt) counts were examined once every three days, bone marrow cells were collected to perform colony cultivation on day 14 and 28 after irradiation. The results showed that WBC count recovery time in combination therapy group was significantly earlier than that of the control group (7 d vs 11 d), WBC count recovery velocity in the combination therapy group was no significant different from that of the G-CSF treatment group. Combined therapy significantly promoted Plt count recovery, resulting in less profound nadirs (16.5% vs 8.1%, P < 0.01) and rapid recovery to normal levels (11 d vs 14 d), Plt count recovery velocity in the combination therapy group was no significant different from that of the rmIL-12 treatment group. Culture of bone marrow cells in semi-solid medium also demonstrated that combination of rmIL-12 and G-CSF could stimulate bone marrow cells to form more CFU-GM and CFU-Mix than those of the irradiation control group in vitro on day 14 and 28 after irradiation (P < 0.05). It is concluded that the combination of rmIL-12 and G-CSF can significantly accelerate the recovery of hematopoietic function in mice with acute radiation sickness.

New Peak Temperature Constraints Using RSCM Geothermometry on Lucia Subterrane in Franciscan Complex (California, USA): Detection of Thermal Anomalies in Gold-Bearing Quartz Veins Surrounding.

NASA Astrophysics Data System (ADS)

Lahfid, A.; Delchini, S.; Lacroix, B.

2015-12-01

The occurrence of deposits hosted by carbonaceous materials-rich metasediments is widespread. Therefore, we aims in this study to investigate the potential of the Raman Spectroscopy of Carbonaceous Material (RSCM) geothermometry to detect thermal anomalies in hydrothermal ore deposits environment and to demonstrate the ability of warm fluids, migrating through the sedimentary sequence to locally disturb the thermal gradient and associated peak temperatures. For this purpose, we have chosen the Lucia subterrane in the Franciscan Complex (California, USA), which includes gold-bearing quartz veins that witness a hydrothermal overprint (Underwood et al., 1995).The sediments in this zone essentially comprise greywacke and shale-matrix mélange (e.g. Frey and Robinson, 1999), which have undergone high-pressure, low-temperature metamorphism. The thermal history of the Lucia subterrane has been previously proposed by Underwood et al. (1995), essentially using vitrinite reflectance method (Rm). Rm values increase from the south to the north; they vary between 0.9 and 3.7 % (~150-280°C). All these results suggest that the Lucia subterrane underwent a regional increase of thermal gradient toward the north. Anomalous Rm values from 4.5% to 4.9% (~305-315°C) are recorded near Cape San Martin. These highest temperatures estimated are likely, associated with a late hydrothermal event (Underwood et al., 1995). Estimated Raman temperatures 1) confirmed the increase in the metamorphic grade towards the north already shown by Underwood et al. (1995), using classical methods like mineralogy and vitrinite reflectance and 2) exhibit anomalous values (temperatures reach 350°C). These anomalies are probably due to the later hydrothermal event. This result suggests that RSCM could be used as a reliable tool to determine thermal anomalies caused by hot fluid-flow.

Deep multi-frequency rotation measure tomography of the galaxy cluster A2255

NASA Astrophysics Data System (ADS)

Pizzo, R. F.; de Bruyn, A. G.; Bernardi, G.; Brentjens, M. A.

2011-01-01

Aims: By studying the polarimetric properties of the radio galaxies and the radio filaments belonging to the galaxy cluster Abell 2255, we aim to unveil their 3-dimensional location within the cluster. Methods: We performed WSRT observations of A2255 at 18, 21, 25, 85, and 200 cm. The polarization images of the cluster were processed through rotation measure (RM) synthesis, producing three final RM cubes. Results: The radio galaxies and the filaments at the edges of the halo are detected in the high-frequency RM cube, obtained by combining the data at 18, 21, and 25 cm. Their Faraday spectra show different levels of complexity. The radio galaxies lying near by the cluster center have Faraday spectra with multiple peaks, while those at large distances show only one peak, as do the filaments. Similar RM distributions are observed for the external radio galaxies and for the filaments, with much lower average RM values and RM variance than those found in previous works for the central radio galaxies. The 85 cm RM cube is dominated by the Galactic foreground emission, but it also shows features associated with the cluster. At 2 m, no polarized emission from A2255 nor our Galaxy is detected. Conclusions: The radial trend observed in the RM distributions of the radio galaxies and in the complexity of their Faraday spectra favors the interpretation that the external Faraday screen for all the sources in A2255 is the ICM. Its differential contribution depends on the amount of medium that the radio signal crosses along the line of sight. The filaments should therefore be located at the periphery of the cluster, and their apparent central location comes from projection effects. Their high fractional polarization and morphology suggest that they are relics rather than part of a genuine radio halo. Their inferred large distance from the cluster center and their geometry could argue for an association with large-scale structure (LSS) shocks. The RM cubes in gif format are only available in electronic form at http://www.aanda.org. To request the RM cubes in FITS format, please contact R. F. Pizzo at: pizzo@astron.nl

Cost-effectiveness of HPV vaccination in the prevention of cervical cancer in Malaysia.

PubMed

Ezat, Wan Puteh Sharifa; Aljunid, Syed

2010-01-01

Cervical cancers (CC) demonstrate the second highest incidence of female cancers in Malaysia. The costs of chronic management have a high impact on nation's health cost and patient's quality of life that can be avoided by better screening and HPV vaccination. Respondents were interviewed from six public Gynecology-Oncology hospitals. Methods include experts' panel discussions to estimate treatment costs by severity and direct interviews with respondents using costing and SF-36 quality of life (QOL) questionnaires. Three options were compared i.e. screening via Pap smear; quadrivalent HPV Vaccination and combined strategy (screening plus vaccination). Scenario based sensitivity analysis using screening population coverage (40-80%) and costs of vaccine (RM 300-400/dose) were calculated. 502 cervical pre invasive and invasive cervical cancer (ICC) patients participated in the study. Mean age was 53.3 +/- 11.2 years, educated till secondary level (39.4%), Malays (44.2%) and married for 27.73 +/- 12.1 years. Life expectancy gained from vaccination is 13.04 years and average Quality Adjusted Life Years saved (QALYs) is 24.4 in vaccinated vs 6.29 in unvaccinated. Cost/QALYs for Pap smear at base case is RM 1,214.96/QALYs and RM 1,100.01 at increased screening coverage; for HPV Vaccination base case is at RM 35,346.79 and RM 46,530.08 when vaccination price is higher. In combined strategy, base case is RM 11,289.58; RM 7,712.74 at best case and RM 14,590.37 at worst case scenario. Incremental cost-effectiveness ratio (ICER) showed that screening at 70% coverage or higher is highly cost effective at RM 946.74 per QALYs saved and this is followed by combined strategy at RM 35,346.67 per QALYs saved. Vaccination increase life expectancy with better QOL of women when cancer can be avoided. Cost effective strategies will include increasing the Pap smear coverage to 70% or higher. Since feasibility and long term screening adherence is doubtful among Malaysian women, vaccination of young women is a more cost effective strategy against cervical cancers.

Multilaboratory trial for determination of ceftiofur residues in bovine and swine kidney and muscle, and bovine milk.

PubMed

Hornish, Rex E; Hamlow, Philip J; Brown, Scott A

2003-01-01

A multilaboratory trial for determining ceftiofur-related residues in bovine and swine kidney and muscle, and bovine milk was conducted following regulatory guidelines of the U.S. Food and Drug Administration, Center for Veterinary Medicine. The methods convert all desfuroylceftiofur-related residues containing the intact beta-lactam ring to desfuroylceftiofur acetamide to establish ceftiofur residues in tissues. Four laboratories analyzed 5 sets of samples for each tissue. Each sample set consisted of a control/blank sample and 3 control samples fortified with ceftiofur at 0.5 Rm, Rm, and 2 Rm, respectively, where Rm is the U.S. tolerance assigned for ceftiofur residue in each tissue/matrix: 0.100 microg/mL for milk, 8.0 microg/g for kidney (both species), 1.0 microg/g for bovine muscle, and 2.0 microg/g for swine muscle. Each sample set also contained 2 samples of incurred-residue tissues (one > Rm and one < Rm) from animals treated with ceftiofur hydrochloride. All laboratories completed the method trial after a familiarization phase and test of system suitability in which they demonstrated > 80% recovery in pretrial fortified test samples. Results showed that the methods met all acceptable performance criteria for recovery, accuracy, and precision. Although sample preparation was easy, solid-phase extraction cartridge performance must be carefully evaluated before samples are processed. The liquid chromatography detection system was easily set up; however, the elution profile may require slight modifications. The procedures could clearly differentiate between violative (> Rm) and nonviolative (< Rm) ceftiofur residues. Participating laboratories found the procedures suitable for ceftiofur residue determination.

Influence of the pH on the accumulation of phosphate by red mud (a bauxite ore processing waste).

PubMed

Castaldi, Paola; Silvetti, Margherita; Garau, Giovanni; Deiana, Salvatore

2010-10-15

In the present work we investigated the interactions established between red mud (RM) and phosphate anions (P) at pH 4.0, 7.0 and 10.0. The amount of P sorbed by RM (P-RM) increased as the pH decreased being equal to 4.871 mmol g(-1) at pH 4.0, 0.924 mmol g(-1) at pH 7.0, and 0.266 mmol g(-1) at pH 10.0. Sequential extractions' data of P-RM equilibrated at pH 4.0 and 7.0, suggested that the phosphate sorption at these pH values was mainly regulated by two different mechanisms that gave rise to a chemical adsorption on RM phases, and to the formation of metal phosphate precipitates. By contrast, at pH 10.0 the P-sorption was regulated by a chemisorption mechanism on Fe-Al phases of RM. These findings were supported by FT-IR analysis, which showed a broad band at 1114 and 1105 cm(-1) in P-RM spectra at pH 4.0 and 7.0 respectively, attributable to P-O(H) stretching nu(3)-modes associated to inner-sphere complexes of phosphate on Fe-Al phases, or alternatively to stretching vibrations of PO(4)(3-) tetrahedra, arising from a precipitate of aluminium phosphate. Importantly, the FT-IR spectroscopy showed a phosphate-promoted dissolution of tectosilicates, notably cancrinite and sodalite, in RM exchanged with phosphate at pH 4.0 and 7.0. 2010 Elsevier B.V. All rights reserved.

Association Between Maximal Bench Press Strength and Isometric Handgrip Strength Among Breast Cancer Survivors.

PubMed

Rogers, Benjamin H; Brown, Justin C; Gater, David R; Schmitz, Kathryn H

2017-02-01

To characterize the relationship between 1-repetition maximum (1-RM) bench press strength and isometric handgrip strength among breast cancer survivors. Cross-sectional study. Laboratory. Community-dwelling breast cancer survivors (N=295). Not applicable. 1-RM bench press strength was measured with a barbell and exercise bench. Isometric handgrip strength was measured using an isometric dynamometer, with 3 maximal contractions of the left and right hands. All measures were conducted by staff with training in clinical exercise testing. Among 295 breast cancer survivors, 1-RM bench press strength was 18.2±6.1kg (range, 2.2-43.0kg), and isometric handgrip strength was 23.5±5.8kg (range, 9.0-43.0kg). The strongest correlate of 1-RM bench press strength was the average isometric handgrip strength of both hands (r=.399; P<.0001). Mean difference analysis suggested that the average isometric handgrip strength of both hands overestimated 1-RM bench press strength by 4.7kg (95% limits of agreement, -8.2 to 17.6kg). In a multivariable linear regression model, the average isometric handgrip strength of both hands (β=.31; P<.0001) and age (β=-.20; P<.0001) were positively correlated with 1-RM bench press strength (R 2 =.23). Isometric handgrip strength is a poor surrogate for 1-RM bench press strength among breast cancer survivors. 1-RM bench press strength and isometric handgrip strength quantify distinct components of muscular strength. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Functional and real-time requirements of a multisensor data fusion (MSDF) situation and threat assessment (STA) resource management (RM) system

NASA Astrophysics Data System (ADS)

Duquet, Jean Remi; Bergeron, Pierre; Blodgett, Dale E.; Couture, Jean; Macieszczak, Maciej; Mayrand, Michel; Chalmers, Bruce A.; Paradis, Stephane

1998-03-01

The Research and Development group at Lockheed Martin Canada, in collaboration with the Defence Research Establishment Valcartier, has undertaken a research project in order to capture and analyze the real-time and functional requirements of a next generation Command and Control System (CCS) for the Canadian Patrol Frigates, integrating Multi- Sensor Data Fusion (MSDF), Situation and Threat Assessment (STA) and Resource Management (RM). One important aspect of the project is to define how the use of Artificial Intelligence may optimize the performance of an integrated, real-time MSDF/STA/RM system. A closed-loop simulation environment is being developed to facilitate the evaluation of MSDF/STA/RM concepts, algorithms and architectures. This environment comprises (1) a scenario generator, (2) complex sensor, hardkill and softkill weapon models, (3) a real-time monitoring tool, (4) a distributed Knowledge-Base System (KBS) shell. The latter is being completely redesigned and implemented in-house since no commercial KBS shell could adequately satisfy all the project requirements. The closed- loop capability of the simulation environment, together with its `simulated real-time' capability, allows the interaction between the MSDF/STA/RM system and the environment targets during the execution of a scenario. This capability is essential to measure the performance of many STA and RM functionalities. Some benchmark scenarios have been selected to demonstrate quantitatively the capabilities of the selected MSDF/STA/RM algorithms. The paper describes the simulation environment and discusses the MSDF/STA/RM functionalities currently implemented and their performance as an automatic CCS.

The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers.

PubMed

Kenmogne, Lucie Carolle; Ayan, Diana; Roy, Jenny; Maltais, René; Poirier, Donald

2015-01-01

Ovarian and pancreatic cancers are two of the most aggressive and lethal cancers, whose management faces only limited therapeutic options. Typically, these tumors spread insidiously accompanied first with atypical symptoms, and usually shift to a drug resistance phenotype with the current pharmaceutical armamentarium. Thus, the development of new drugs acting via a different mechanism of action represents a clear priority. Herein, we are reporting for the first time that the aminosteroid derivative RM-133, developed in our laboratory, displays promising activity on two models of aggressive cancers, namely ovarian (OVCAR-3) and pancreatic (PANC-1) cancers. The IC50 value of RM-133 was 0.8 μM and 0.3 μM for OVCAR-3 and PANC-1 cell lines in culture, respectively. Based on pharmacokinetic studies on RM-133 using 11 different vehicles, we selected two main vehicles: aqueous 0.4% methylcellulose:ethanol (92:8) and sunflower oil:ethanol (92:8) for in vivo studies. Using subcutaneous injection of RM-133 with the methylcellulose-based vehicle, growth of PANC-1 tumors xenografted to nude mice was inhibited by 63%. Quite interestingly, RM-133 injected subcutaneously with the methylcellulose-based or sunflower-based vehicles reduced OVCAR-3 xenograft growth by 122% and 100%, respectively. After the end of RM-133 treatment using the methylcellulose-based vehicle, OVCAR-3 tumor growth inhibition was maintained for ≥ 1 week. RM-133 was also well tolerated in the whole animal, no apparent sign of toxicity having been detected in the xenograft studies.

The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers

PubMed Central

Kenmogne, Lucie Carolle; Ayan, Diana; Roy, Jenny; Maltais, René; Poirier, Donald

2015-01-01

Ovarian and pancreatic cancers are two of the most aggressive and lethal cancers, whose management faces only limited therapeutic options. Typically, these tumors spread insidiously accompanied first with atypical symptoms, and usually shift to a drug resistance phenotype with the current pharmaceutical armamentarium. Thus, the development of new drugs acting via a different mechanism of action represents a clear priority. Herein, we are reporting for the first time that the aminosteroid derivative RM-133, developed in our laboratory, displays promising activity on two models of aggressive cancers, namely ovarian (OVCAR-3) and pancreatic (PANC-1) cancers. The IC50 value of RM-133 was 0.8 μM and 0.3 μM for OVCAR-3 and PANC-1 cell lines in culture, respectively. Based on pharmacokinetic studies on RM-133 using 11 different vehicles, we selected two main vehicles: aqueous 0.4% methylcellulose:ethanol (92:8) and sunflower oil:ethanol (92:8) for in vivo studies. Using subcutaneous injection of RM-133 with the methylcellulose-based vehicle, growth of PANC-1 tumors xenografted to nude mice was inhibited by 63%. Quite interestingly, RM-133 injected subcutaneously with the methylcellulose-based or sunflower-based vehicles reduced OVCAR-3 xenograft growth by 122% and 100%, respectively. After the end of RM-133 treatment using the methylcellulose-based vehicle, OVCAR-3 tumor growth inhibition was maintained for ≥ 1 week. RM-133 was also well tolerated in the whole animal, no apparent sign of toxicity having been detected in the xenograft studies. PMID:26660672

Trunk muscle activation during dynamic weight-training exercises and isometric instability activities.

PubMed

Hamlyn, Nicolle; Behm, David G; Young, Warren B

2007-11-01

The purpose of this study was to examine the extent of activation in various trunk muscles during dynamic weight-training and isometric instability exercises. Sixteen subjects performed squats and deadlifts with 80% 1 repetition maximum (1RM), as well as with body weight as resistance and 2 unstable calisthenic-type exercises (superman and sidebridge). Electromyographic (EMG) activity was measured from the lower abdominals (LA), external obliques (EO), upper lumbar erector spinae (ULES), and lumbar-sacral erector spinae (LSES) muscle groups. Results indicated that the LSES EMG activity during the 80% 1RM squat significantly exceeded 80% 1RM deadlift LSES EMG activity by 34.5%. The LSES EMG activity of the 80% 1RM squat also exceeded the body weight squat, deadlift, superman, and sidebridge by 56, 56.6, 65.5, and 53.1%, respectively. The 80% 1RM deadlift ULES EMG activity significantly exceeded the 80% 1RM squat exercise by 12.9%. In addition, the 80% 1RM deadlift ULES EMG activity also exceeded the body weight squat, deadlift, superman, and sidebridge exercises by 66.7, 65.5, 69.3, and 68.6%, respectively. There were no significant changes in EO or LA activity. Therefore, the augmented activity of the LSES and ULES during 80% 1RM squat and deadlift resistance exercises exceeded the activation levels achieved with the same exercises performed with body weight and selected instability exercises. Individuals performing upright, resisted, dynamic exercises can achieve high trunk muscle activation and thus may not need to add instability device exercises to augment core stability training.

Salivary hormone and immune responses to three resistance exercise schemes in elite female athletes.

PubMed

Nunes, João A; Crewther, Blair T; Ugrinowitsch, Carlos; Tricoli, Valmor; Viveiros, Luís; de Rose, Dante; Aoki, Marcelo S

2011-08-01

This study examined the salivary hormone and immune responses of elite female athletes to 3 different resistance exercise schemes. Fourteen female basketball players each performed an endurance scheme (ES-4 sets of 12 reps, 60% of 1 repetition maximum (1RM) load, 1-minute rest periods), a strength-hypertrophy scheme (SHS-1 set of 5RM, 1 set of 4RM, 1 set of 3RM, 1 set of 2RM, and 1set of 1RM with 3-minute rest periods, followed by 3 sets of 10RM with 2-minute rest periods) and a power scheme (PS-3 sets of 10 reps, 50% 1RM load, 3-minute rest periods) using the same exercises (bench press, squat, and biceps curl). Saliva samples were collected at 07:30 hours, pre-exercise (Pre) at 09:30 hours, postexercise (Post), and at 17:30 hours. Matching samples were also taken on a nonexercising control day. The samples were analyzed for testosterone, cortisol (C), and immunoglobulin A concentrations. The total volume of load lifted differed among the 3 schemes (SHS > ES > PS, p < 0.05). Postexercise C concentrations increased after all schemes, compared to control values (p < 0.05). In the SHS, the postexercise C response was also greater than pre-exercise data (p < 0.05). The current findings confirm that high-volume resistance exercise schemes can stimulate greater C secretion because of higher metabolic demand. In terms of practical applications, acute changes in C may be used to evaluate the metabolic demands of different resistance exercise schemes, or as a tool for monitoring training strain.

Nonlinear vibrations and dynamic stability of viscoelastic orthotropic rectangular plates

NASA Astrophysics Data System (ADS)

Eshmatov, B. Kh.

2007-03-01

This paper describes the analyses of the nonlinear vibrations and dynamic stability of viscoelastic orthotropic plates. The models are based on the Kirchhoff-Love (K.L.) hypothesis and Reissner-Mindlin (R.M.) generalized theory (with the incorporation of shear deformation and rotatory inertia) in geometrically nonlinear statements. It provides justification for the choice of the weakly singular Koltunov-Rzhanitsyn type kernel, with three rheological parameters. In addition, the implication of each relaxation kernel parameter has been studied. To solve problems of viscoelastic systems with weakly singular kernels of relaxation, a numerical method has been used, based on quadrature formulae. With a combination of the Bubnov-Galerkin and the presented method, problems of nonlinear vibrations and dynamic stability in viscoelastic orthotropic rectangular plates have been solved, according to the K.L. and R.M. hypotheses. A comparison of the results obtained via these theories is also presented. In all problems, the convergence of the Bubnov-Galerkin method has been investigated. The implications of material viscoelasticity on vibration and dynamic stability are presented graphically.

Impact of Different Ventilation Strategies on Driving Pressure, Mechanical Power, and Biological Markers During Open Abdominal Surgery in Rats.

PubMed

Maia, Lígia de A; Samary, Cynthia S; Oliveira, Milena V; Santos, Cintia L; Huhle, Robert; Capelozzi, Vera L; Morales, Marcelo M; Schultz, Marcus J; Abreu, Marcelo G; Pelosi, Paolo; Silva, Pedro L; Rocco, Patricia Rieken Macedo

2017-10-01

Intraoperative mechanical ventilation may yield lung injury. To date, there is no consensus regarding the best ventilator strategy for abdominal surgery. We aimed to investigate the impact of the mechanical ventilation strategies used in 2 recent trials (Intraoperative Protective Ventilation [IMPROVE] trial and Protective Ventilation using High versus Low PEEP [PROVHILO] trial) on driving pressure (ΔPRS), mechanical power, and lung damage in a model of open abdominal surgery. Thirty-five Wistar rats were used, of which 28 were anesthetized, and a laparotomy was performed with standardized bowel manipulation. Postoperatively, animals (n = 7/group) were randomly assigned to 4 hours of ventilation with: (1) tidal volume (VT) = 7 mL/kg and positive end-expiratory pressure (PEEP) = 1 cm H2O without recruitment maneuvers (RMs) (low VT/low PEEP/RM-), mimicking the low-VT/low-PEEP strategy of PROVHILO; (2) VT = 7 mL/kg and PEEP = 3 cm H2O with RMs before laparotomy and hourly thereafter (low VT/moderate PEEP/4 RM+), mimicking the protective ventilation strategy of IMPROVE; (3) VT = 7 mL/kg and PEEP = 6 cm H2O with RMs only before laparotomy (low VT/high PEEP/1 RM+), mimicking the strategy used after intubation and before extubation in PROVHILO; or (4) VT = 14 mL/kg and PEEP = 1 cm H2O without RMs (high VT/low PEEP/RM-), mimicking conventional ventilation used in IMPROVE. Seven rats were not tracheotomized, operated, or mechanically ventilated, and constituted the healthy nonoperated and nonventilated controls. Low VT/moderate PEEP/4 RM+ and low VT/high PEEP/1 RM+, compared to low VT/low PEEP/RM- and high VT/low PEEP/RM-, resulted in lower ΔPRS (7.1 ± 0.8 and 10.2 ± 2.1 cm H2O vs 13.9 ± 0.9 and 16.9 ± 0.8 cm H2O, respectively; P< .001) and less mechanical power (63 ± 7 and 79 ± 20 J/min vs 110 ± 10 and 120 ± 20 J/min, respectively; P = .007). Low VT/high PEEP/1 RM+ was associated with less alveolar collapse than low VT/low PEEP/RM- (P = .03). E-cadherin expression was higher in low VT/moderate PEEP/4 RM+ than in low VT/low PEEP/RM- (P = .013) or high VT/low PEEP/RM- (P = .014). The extent of alveolar collapse, E-cadherin expression, and tumor necrosis factor-alpha correlated with ΔPRS (r = 0.54 [P = .02], r = -0.48 [P = .05], and r = 0.59 [P = .09], respectively) and mechanical power (r = 0.57 [P = .02], r = -0.54 [P = .02], and r = 0.48 [P = .04], respectively). In this model of open abdominal surgery based on the mechanical ventilation strategies used in IMPROVE and PROVHILO trials, lower mechanical power and its surrogate ΔPRS were associated with reduced lung damage.

Complete genome sequence of salmonella enterica subsp. enterica Serovar Thompson Strain RM6836

USDA-ARS?s Scientific Manuscript database

Salmonella enterica subsp. enterica serovar Thompson (S. Thompson) strain RM6836 was isolated from lettuce in 2002. We report the complete sequence and annotation of the genome of S. Thompson strain RM6836. This is the first reported complete genome sequence for S. Thompson and will provide a point ...

Using conjoint analysis to measure the acceptability of rectal microbicides among men who have sex with men in four South American cities.

PubMed

Kinsler, Janni J; Cunningham, William E; Nureña, César R; Nadjat-Haiem, Carsten; Grinsztejn, Beatriz; Casapia, Martin; Montoya-Herrera, Orlando; Sánchez, Jorge; Galea, Jerome T

2012-08-01

Conjoint Analysis (CJA), a statistical market-based technique that assesses the value consumers place on product characteristics, may be used to predict acceptability of hypothetical products. Rectal Microbicides (RM)-substances that would prevent HIV infection during receptive anal intercourse-will require acceptability data from potential users in multiple settings to inform the development process by providing valuable information on desirable product characteristics and issues surrounding potential barriers to product use. This study applied CJA to explore the acceptability of eight different hypothetical RM among 128 MSM in Lima and Iquitos, Peru; Guayaquil, Ecuador; and Rio de Janeiro, Brazil. Overall RM acceptability was highest in Guayaquil and lowest in Rio. Product effectiveness had the greatest impact on acceptability in all four cities, but the impact of other product characteristics varied by city. This study demonstrates that MSM from the same region but from different cities place different values on RM characteristics that could impact uptake of an actual RM. Understanding specific consumer preferences is crucial during RM product development, clinical trials and eventual product dissemination.

Genetic diversity of the HpyC1I restriction modification system in Helicobacter pylori.

PubMed

Lehours, Philippe; Dupouy, Sandrine; Chaineux, Julien; Ruskoné-Fourmestraux, Agnès; Delchier, Jean-Charles; Morgner, Andrea; Mégraud, Francis; Ménard, Armelle

2007-04-01

Helicobacter pylori is unique because of the unusually high number and diversity of its restriction modification (R-M) systems. HpyC1I R-M was recently characterized and contains an endonuclease which is an isoschizomer of the endonuclease BccI. This R-M is involved in adherence to gastric epithelial cells, a crucial step in bacterial pathogenesis. This observation illustrates the fact that R-M systems have other putative biological functions in addition to protecting the bacterial genome from external DNA. The genomic diversity of HpyC1I R-M was evaluated more precisely on a large collection of H. pylori strains by PCR, susceptibility to BccI digestion and sequencing. The results obtained support the mechanism of gain and loss of this R-M system in the H. pylori genome, and suggest that it is an ancestral system which gradually disappears during H. pylori evolution, following successive steps: (1) inactivation of the endonuclease gene, followed or accompanied by: (2) inactivation of the methyltransferase genes, and then: (3) definitive loss, leaving only short endonuclease remnant sequences.

Remote Monitoring for Follow-up of Patients with Cardiac Implantable Electronic Devices

PubMed Central

Morichelli, Loredana; Varma, Niraj

2014-01-01

Follow-up of patients with cardiac implantable electronic devices is challenging due to the increasing number and technical complexity of devices coupled to increasing clinical complexity of patients. Remote monitoring (RM) offers the opportunity to optimise clinic workflow and to improve device monitoring and patient management. Several randomised clinical trials and registries have demonstrated that RM may reduce number of hospital visits, time required for patient follow-up, physician and nurse time, hospital and social costs. Furthermore, patient retention and adherence to follow-up schedule are significantly improved by RM. Continuous wireless monitoring of data stored in the device memory with automatic alerts allows early detection of device malfunctions and of events requiring clinical reaction, such as atrial fibrillation, ventricular arrhythmias and heart failure. Early reaction may improve patient outcome. RM is easy to use and patients showed a high level of acceptance and satisfaction. Implementing RM in daily practice may require changes in clinic workflow. To this purpose, new organisational models have been introduced. In spite of a favourable cost:benefit ratio, RM reimbursement still represents an issue in several European countries. PMID:26835079

Calibration Adjustment of the Mid-infrared Analyzer for an Accurate Determination of the Macronutrient Composition of Human Milk.

PubMed

Billard, Hélène; Simon, Laure; Desnots, Emmanuelle; Sochard, Agnès; Boscher, Cécile; Riaublanc, Alain; Alexandre-Gouabau, Marie-Cécile; Boquien, Clair-Yves

2016-08-01

Human milk composition analysis seems essential to adapt human milk fortification for preterm neonates. The Miris human milk analyzer (HMA), based on mid-infrared methodology, is convenient for a unique determination of macronutrients. However, HMA measurements are not totally comparable with reference methods (RMs). The primary aim of this study was to compare HMA results with results from biochemical RMs for a large range of protein, fat, and carbohydrate contents and to establish a calibration adjustment. Human milk was fractionated in protein, fat, and skim milk by covering large ranges of protein (0-3 g/100 mL), fat (0-8 g/100 mL), and carbohydrate (5-8 g/100 mL). For each macronutrient, a calibration curve was plotted by linear regression using measurements obtained using HMA and RMs. For fat, 53 measurements were performed, and the linear regression equation was HMA = 0.79RM + 0.28 (R(2) = 0.92). For true protein (29 measurements), the linear regression equation was HMA = 0.9RM + 0.23 (R(2) = 0.98). For carbohydrate (15 measurements), the linear regression equation was HMA = 0.59RM + 1.86 (R(2) = 0.95). A homogenization step with a disruptor coupled to a sonication step was necessary to obtain better accuracy of the measurements. Good repeatability (coefficient of variation < 7%) and reproducibility (coefficient of variation < 17%) were obtained after calibration adjustment. New calibration curves were developed for the Miris HMA, allowing accurate measurements in large ranges of macronutrient content. This is necessary for reliable use of this device in individualizing nutrition for preterm newborns. © The Author(s) 2015.

Molecular identification and characterisation of catalase and catalase-like protein genes in urease-positive thermophilic Campylobacter (UPTC).

PubMed

Nakajima, T; Kuribayashi, T; Moore, J E; Millar, B C; Yamamoto, S; Matsuda, Motoo

2016-01-01

Thermophilic Campylobacter are important bacterial pathogens of foodborne diseases worldwide. These organisms' physiology requires a microaerophilic atmosphere. To date, little is known about the protective catalase mechanism in urease-positive thermophilic campylobacters (UPTC); hence, it was the aim of this study to identify and characterise catalase and catalase-like protein genes in these organisms. Catalase (katA) and catalase (Kat)-like protein genes from the Japanese UPTC CF89-12 strain were molecularly analysed and compared with C. lari RM2100 and other C. lari and thermophilic Campylobacter reference isolates. A possible open reading frame of 1,422 base pairs, predicted to encode a peptide of 474 amino acid residues, with calculated molecular weight of 52.7 kilo Daltons for katA, was identified within UPTC CF89-12. A probable ribosome binding site, two putative promoters and a putative ρ-independent transcription terminator were also identified within katA. A similar katA cluster also existed in the C. lari RM2100 strain, except that this strain carries no DcuB genes. However, the Kat-like protein gene or any other homologue(s) were never identified in the C. lari RM2100 strain, or in C. jejuni and C. upsaliensis. This study demonstrates the presence of catalase/catalase-like protein genes in UPTC organisms. These findings are significant in that they suggest that UPTC organisms have the protective genetic capability of helping protect the organisms from toxic oxygen stress, which may help them to survive in physiologically harsh environments, both within human and animal hosts, as well as in the natural environment.

Genetic analysis and fine mapping of a rice brown planthopper (Nilaparvata lugens Stål) resistance gene bph19(t).

PubMed

Chen, J W; Wang, L; Pang, X F; Pan, Q H

2006-04-01

Genetic analysis and fine mapping of a resistance gene against brown planthopper (BPH) biotype 2 in rice was performed using two F(2) populations derived from two crosses between a resistant indica cultivar (cv.), AS20-1, and two susceptible japonica cvs., Aichi Asahi and Lijiangxintuanheigu. Insect resistance was evaluated using F(1) plants and the two F(2) populations. The results showed that a single recessive gene, tentatively designated as bph19(t), conditioned the resistance in AS20-1. A linkage analysis, mainly employing microsatellite markers, was carried out in the two F(2) populations through bulked segregant analysis and recessive class analysis (RCA), in combination with bioinformatics analysis (BIA). The resistance gene locus bph19(t) was finely mapped to a region of about 1.0 cM on the short arm of chromosome 3, flanked by markers RM6308 and RM3134, where one known marker RM1022, and four new markers, b1, b2, b3 and b4, developed in the present study were co-segregating with the locus. To physically map this locus, the bph19(t)-linked markers were landed on bacterial artificial chromosome or P1 artificial chromosome clones of the reference cv., Nipponbare, released by the International Rice Genome Sequencing Project. Sequence information of these clones was used to construct a physical map of the bph19(t) locus, in silico, by BIA. The bph19(t) locus was physically defined to an interval of about 60 kb. The detailed genetic and physical maps of the bph19(t) locus will facilitate marker-assisted gene pyramiding and cloning.

Soil respiration sensitivities to water and temperature in a revegetated desert

NASA Astrophysics Data System (ADS)

Zhang, Zhi-Shan; Dong, Xue-Jun; Xu, Bing-Xin; Chen, Yong-Le; Zhao, Yang; Gao, Yan-Hong; Hu, Yi-Gang; Huang, Lei

2015-04-01

Soil respiration in water-limited ecosystems is affected intricately by soil water content (SWC), temperature, and soil properties. Eight sites on sand-fixed dunes that revegetated in different years since 1950s, with several topographical positions and various biological soil crusts (BSCs) and soil properties, were selected, as well as a moving sand dune (MSD) and a reference steppe in the Tengger Desert of China. Intact soil samples of 20 cm in depth were taken and incubated randomly at 12 levels of SWC (0 to 0.4 m3 m-3) and at 9 levels of temperature (5 to 45°C) in a growth chamber; additionally, cryptogamic and microbial respirations (RM) were measured. Total soil respiration (RT, including cryptogamic, microbial, and root respiration) was measured for 2 years at the MSD and five sites of sand-fixed dunes. The relationship between RM and SWC under the optimal SWC condition (0.25 m3 m-3) is linear, as is the entire range of RT and SWC. The slope of linear function describes sensitivity of soil respiration to water (SRW) and reflects to soil water availability, which is related significantly to soil physical properties, BSCs, and soil chemical properties, in decreasing importance. Inversely, Q10 for RM is related significantly to abovementioned factors in increasing importance. However, Q10 for RT and respiration rate at 20°C are related significantly to soil texture and depth of BSCs and subsoil only. In conclusion, through affecting SRW, soil physical properties produce significant influences on soil respiration, especially for RT. This indicates that a definition of the biophysical meaning of SRW is necessary, considering the water-limited and coarse-textured soil in most desert ecosystems.

Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.

PubMed

Zhang, Fan; Hu, Jing; Kelsey, Chris R; Yoo, David; Yin, Fang-Fang; Cai, Jing

2012-11-01

To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images. Cine MV images of 20 patients acquired during three-dimensional conformal (6-11 beams) SBRT treatments were retrospectively analyzed to extract tumor motion trajectories. For each patient, tumor motion PDFs were generated per fraction (PDF(n)) using three selected "usable" beams. Patients without at least three usable beams were excluded from the study. Fractional PDF reproducibility (R(n)) was calculated as the Dice similarity coefficient between PDF(n) to a "ground-truth" PDF (PDF(g)), which was generated using the selected beams of all fractions. The mean of R(n), labeled as R(m), was calculated for each patient and correlated to the patient's mean tumor motion rang (A(m)). Change of R(m) during the course of SBRT treatments was also evaluated. Intra- and intersubject coefficient of variation (CV) of R(m) and A(m) were determined. Thirteen patients had at least three usable beams and were analyzed. The mean of R(m) was 0.87 (range, 0.84-0.95). The mean of A(m) was 3.18 mm (range, 0.46-7.80 mm). R(m) was found to decrease as A(m) increases following an equation of R(m) = 0.17e(-0.9Am) + 0.84. R(m) also decreased slightly throughout the course of treatments. Intersubject CV of R(m) (0.05) was comparable to intrasubject CV of R(m) (range, 0.02-0.09); intersubject CV of A(m) (0.73) was significantly greater than intrasubject CV of A(m) (range, 0.09-0.24). Tumor motion PDF can be determined using cine MV images acquired during the treatments. The reproducibility of lung tumor motion PDF decreased exponentially as the tumor motion range increased and decreased slightly throughout the course of the treatments. Copyright © 2012 Elsevier Inc. All rights reserved.

Parental Restriction of Mature-rated Media and Its Association With Substance Use Among Argentinean Adolescents.

PubMed

Mejia, Raul; Pérez, Adriana; Peña, Lorena; Morello, Paola; Kollath-Cattano, Christy; Braun, Sandra; Thrasher, James F; Sargent, James D

2016-04-01

To assess the independent relation between parental restrictions on mature-rated media (M-RM) and substance use among South American adolescents. Cross-sectional school-based youth survey of 3,172 students (mean age, 12.8 years; 57.6% boys) in 3 large Argentinean cities. The anonymous survey queried tobacco, alcohol, and drug use using items adapted from global youth surveys. Adolescents reported M-RM restriction for internet and video game use, television programming, and movies rated for adults. Multivariate logistic regression models were used to assess the association between parental M-RM restriction and substance use after adjustment for hourly media use, measures of authoritative parenting style, sociodemographic characteristics, and sensation-seeking. Substance use rates were 10% for current smoking, 32% for current drinking alcohol, 17% for past 30-day binge drinking, and 8% for illicit drug use (marijuana or cocaine). Half of the respondents reported parental M-RM restriction (internet 52%, TV 43%, adult movies 34%, video game 25%). Parental M-RM restriction was only modestly correlated with authoritative parenting measures. In multivariate analyses M-RM restriction on all 4 venues was strongly protective for all substance use outcomes. Compared with no restriction, odds ratios for substance use for full restrictions were 0.32 (0.18-0.59), 0.53 (0.38-0.07), 0.36 (0.22-0.59), and 0.49 (0.26-0.92) for current smoking, drinking, binge drinking, and illicit drug use, respectively. The most important single M-RM venue was movies. Results of this study confirmed the protective association between parental M-RM restriction during adolescence and multiple substance use outcomes, including illicit drugs. M-RM restriction is independent of traditional parenting measures. The preponderance of the evidence supports intervention development. Copyright © 2016 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

mRM - multiscale Routing Model for Land Surface and Hydrologic Models

NASA Astrophysics Data System (ADS)

Cuntz, M.; Thober, S.; Mai, J.; Samaniego, L. E.; Gochis, D. J.; Kumar, R.

2015-12-01

Routing streamflow through a river network is a basic step within any distributed hydrologic model. It integrates the generated runoff and allows comparison with observed discharge at the outlet of a catchment. The Muskingum routing is a textbook river routing scheme that has been implemented in Earth System Models (e.g., WRF-HYDRO), stand-alone routing schemes (e.g., RAPID), and hydrologic models (e.g., the mesoscale Hydrologic Model). Most implementations suffer from a high computational demand because the spatial routing resolution is fixed to that of the elevation model irrespective of the hydrologic modeling resolution. This is because the model parameters are scale-dependent and cannot be used at other resolutions without re-estimation. Here, we present the multiscale Routing Model (mRM) that allows for a flexible choice of the routing resolution. mRM exploits the Multiscale Parameter Regionalization (MPR) included in the open-source mesoscale Hydrologic Model (mHM, www.ufz.de/mhm) that relates model parameters to physiographic properties and allows to estimate scale-independent model parameters. mRM is currently coupled to mHM and is presented here as stand-alone Free and Open Source Software (FOSS). The mRM source code is highly modular and provides a subroutine for internal re-use in any land surface scheme. mRM is coupled in this work to the state-of-the-art land surface model Noah-MP. Simulation results using mRM are compared with those available in WRF-HYDRO for the Red River during the period 1990-2000. mRM allows to increase the routing resolution from 100m to more than 10km without deteriorating the model performance. Therefore, it speeds up model calculation by reducing the contribution of routing to total runtime from over 80% to less than 5% in the case of WRF-HYDRO. mRM thus makes discharge data available to land surface modeling with only little extra calculations.

Model-based observer and feedback control design for a rigid Joukowski foil in a Kármán vortex street.

PubMed

Free, Brian A; Paley, Derek A

2018-03-14

Obstacles and swimming fish in flow create a wake with an alternating left/right vortex pattern known as a Kármán vortex street and reverse Kármán vortex street, respectively. An energy-efficient fish behavior resembling slaloming through the vortex street is called Kármán gaiting. This paper describes the use of a bioinspired array of pressure sensors on a Joukowski foil to estimate and control flow-relative position in a Kármán vortex street using potential flow theory, recursive Bayesian filtering, and trajectory-tracking feedback control. The Joukowski foil is fixed in downstream position in a flowing water channel and free to move on air bearings in the cross-stream direction by controlling its angle of attack to generate lift. Inspired by the lateral-line neuromasts found in fish, the sensing and control scheme is validated using off-the-shelf pressure sensors in an experimental testbed that includes a flapping device to create vortices. We derive a potential flow model that describes the flow over a Joukowski foil in a Kármán vortex street and identify an optimal path through a Kármán vortex street using empirical observability. The optimally observable trajectory is one that passes through each vortex in the street. The estimated vorticity and location of the Kármán vortex street are used in a closed-loop control to track either the optimally observable path or the energetically efficient gait exhibited by fish. Results from the closed-loop control experiments in the flow tank show that the artificial lateral line in conjunction with a potential flow model and Bayesian estimator allow the robot to perform fish-like slaloming behavior in a Kármán vortex street. This work is a precursor to an autonomous robotic fish sensing the wake of another fish and/or performing pursuit and schooling behavior.

RPE and Velocity Relationships for the Back Squat, Bench Press, and Deadlift in Powerlifters.

PubMed

Helms, Eric R; Storey, Adam; Cross, Matt R; Brown, Scott R; Lenetsky, Seth; Ramsay, Hamish; Dillen, Carolina; Zourdos, Michael C

2017-02-01

Helms, ER, Storey, A, Cross, MR, Browm, SR, Lenetsky, S, Ramsay, H, Dillen, C, and Zourdos, MC. RPE and velocity relationships for the back squat, bench press, and deadlift in powerlifters. J Strength Cond Res 31(2): 292-297, 2017-The purpose of this study was to compare average concentric velocity (ACV) and rating of perceived exertion (RPE) based on repetitions in reserve on the squat, bench press, and deadlift. Fifteen powerlifters (3 women and 12 men, mean age 28.4 ± 8.5 years) worked up to a one repetition maximum (1RM) on each lift. Rating of perceived exertion was recorded on all sets, and the ACV was recorded for all sets performed at 80% of estimated 1RM and higher, up to 1RM. Rating of perceived exertion at 1RM on squat, bench press, and deadlift was 9.6 ± 0.5, 9.7 ± 0.4, and 9.6 ± 0.5, respectively and was not significantly different (p > 0.05). The ACV at 1RM on squat, bench press and deadlift was 0.23 ± 0.05, 0.10 ± 0.04, and 0.14 ± 0.05 m·second, respectively. Squat was faster than both bench press and deadlift (p > 0.001), and deadlift was faster than bench press (p = 0.05). Very strong relationships (r = 0.88-0.91) between percentage 1RM and RPE were observed on each lift. The ACV showed strong (r = -0.79 to -0.87) and very strong (r = -0.90 to 92) inverse relationships with RPE and percentage 1RM on each lift, respectively. We conclude that RPE may be a useful tool for prescribing intensity for squat, bench press, and deadlift in powerlifters, in addition to traditional methods such as percentage of 1RM. Despite high correlations between percentage 1RM and ACV, a "velocity load profile" should be developed to prescribe intensity on an individual basis with appropriate accuracy.

Roller Massage: A Descriptive Survey of Allied Health Professionals.

PubMed

Cheatham, Scott W

2018-04-13

In sports medicine, the interprofessional care of athletes has become a frequent practice. This type of care often involves different interventions used among professionals. One common intervention prescribed is roller massage (RM) or self-myofascial release. The trends in the use of RM among allied health professionals is non-existent. The surveillance of such responses has not been documented. To survey and document responses in the knowledge, clinical application, and use of RM devices among allied health professionals in the United States. Cross-sectional descriptive survey study. A 20 question survey was sent to allied health professionals including physical therapists, athletic trainers, and fitness professionals. The survey covered topics such as demographics, beliefs about RM, preferred devices, exercise prescription, and client education. Results One thousand forty-two professionals (N=1042) completed the survey. Most respondents believed that RM decreases pain (82%) and increases mobility (76%). A high percentage use a foam roller in their practice (81%), recommend a full-size foam roller (49%), and believe the medium density (48%) is the most effective. A high proportion of respondents prescribe RM for injury treatment (69%) and for pre-and post-exercise (61%). They also recommend rolling daily for 30 seconds to 2 minutes per muscle group (33%) at a self-paced cadence (46%). A high percentage of respondents use patient reported outcomes (74%), joint ROM (49%), and movement-based testing (48%) to measure effects of RM. Eighty-seven percent use live instruction to educate clients and 88% believe there is a gap in the research. The results of this survey document responses in the use of RM among allied health professionals. The reported responses provide insight into how professionals are using RM as an intervention and the potential gaps between the research and professional practice. Future studies are needed to further validate these findings.

Prevention of biofilm formation and removal of existing biofilms by extracellular DNases of Campylobacter jejuni.

PubMed

Brown, Helen L; Reuter, Mark; Hanman, Kate; Betts, Roy P; van Vliet, Arnoud H M

2015-01-01

The fastidious nature of the foodborne bacterial pathogen Campylobacter jejuni contrasts with its ability to survive in the food chain. The formation of biofilms, or the integration into existing biofilms by C. jejuni, is thought to contribute to food chain survival. As extracellular DNA (eDNA) has previously been proposed to play a role in C. jejuni biofilms, we have investigated the role of extracellular DNases (eDNases) produced by C. jejuni in biofilm formation. A search of 2791 C. jejuni genomes highlighted that almost half of C. jejuni genomes contains at least one eDNase gene, but only a minority of isolates contains two or three of these eDNase genes, such as C. jejuni strain RM1221 which contains the cje0256, cje0566 and cje1441 eDNase genes. Strain RM1221 did not form biofilms, whereas the eDNase-negative strains NCTC 11168 and 81116 did. Incubation of pre-formed biofilms of NCTC 11168 with live C. jejuni RM1221 or with spent medium from a RM1221 culture resulted in removal of the biofilm. Inactivation of the cje1441 eDNase gene in strain RM1221 restored biofilm formation, and made the mutant unable to degrade biofilms of strain NCTC 11168. Finally, C. jejuni strain RM1221 was able to degrade genomic DNA from C. jejuni NCTC 11168, 81116 and RM1221, whereas strain NCTC 11168 and the RM1221 cje1441 mutant were unable to do so. This was mirrored by an absence of eDNA in overnight cultures of C. jejuni RM1221. This suggests that the activity of eDNases in C. jejuni affects biofilm formation and is not conducive to a biofilm lifestyle. These eDNases do however have a potential role in controlling biofilm formation by C. jejuni strains in food chain relevant environments.

Carbon dynamics in peatland pool systems: the role of light

NASA Astrophysics Data System (ADS)

Pickard, Amy; Heal, Kate; McLeod, Andy; Dinsmore, Kerry

2016-04-01

Open-water pools are widespread in peatlands and are considered to represent biogeochemical hotspots within the peatland landscape. However the contribution of pool systems to wider peatland C cycling has not been quantified fully and there is a lack of knowledge of the role of photochemical processes in such environments. In this study, light exposure experiments were conducted in two contrasting pools to test the reactivity of aquatic C. The first study site was located at Cross Lochs (CL), Forsinard, in the Flow Country of Northern Scotland, in a 412 m2 pool characterised by low dissolved organic carbon (DOC) concentrations (˜15 mg C L-1). The second site was located at Red Moss of Balerno (RM), a raised bog in central Scotland, in a 48 m2 pool with high DOC concentrations (˜35 mg C L-1). Experiments took place over 9 days in situ at each pool in mid-summer 2015, with 500 mL water samples contained in bags transparent to sunlight and in opaque control bags. After field exposure, optical, chemical and stable C isotope analyses were conducted on the samples. Significant differences in biogeochemical cycling of DOC were detected between the two systems, with DOC losses as a percentage of the total C pool 15% higher at RM than at CL after light exposure. The mean DOC concentration of light exposed samples at RM declined steeply initially, with 83% observed DOC degradation occurring by day 3 of the experiment. Total losses of 7.9 mg DOC L-1were observed in light exposed samples at RM, along with decreasing E4:E6 ratios, suggesting that material remaining at the end of the experiment was humified. Depletion of DOC was positively correlated with production of CO2 at both sites, with concentrations of up to 4.3 mg CO2-C L-1 recorded at RM. Stable C isotope signatures at both sites were altered under light treatment, as demonstrated by the production of enriched δ13C-DOC (+0.46 ‰ relative to opaque bags) and depleted δ13C-DIC (-0.97 ‰ relative to opaque bags) at RM. However, at CL, the δ13C-DOC signature in both the light exposed and opaque bags was depleted (-0.2‰ and -0.4 ‰ respectively), suggesting that microbial processing was the preferential DOC processing pathway in this system. These results show that C in peatland pools is highly reactive and further demonstrate the importance of photochemical processing of C, which should be considered as a significant driver of biogeochemical cycling.

PET Using a GRPR Antagonist 68Ga-RM26 in Healthy Volunteers and Prostate Cancer Patients.

PubMed

Zhang, Jingjing; Niu, Gang; Fan, Xinrong; Lang, Lixin; Hou, Guozhu; Chen, Libo; Wu, Huanwen; Zhu, Zhaohui; Li, Fang; Chen, Xiaoyuan

2018-06-01

This study was designed to analyze the safety, biodistribution, and radiation dosimetry of a gastrin-releasing peptide receptor (GRPR) antagonist PET tracer, 68 Ga-RM26; to assess its clinical diagnostic value in prostate cancer patients; and to perform a direct comparison between GRPR antagonist 68 Ga-RM26 and agonist 68 Ga-BBN. Methods: Five healthy volunteers were enrolled to validate the safety of 68 Ga-RM26 and calculate dosimetry. A total of 28 patients with prostate cancer (17 newly diagnosed and 11 posttherapy) were recruited and provided written informed consent. All the cancer patients underwent PET/CT at 15-30 min after intravenous injection of 1.85 MBq (0.05 mCi) per kilogram of body weight of 68 Ga-RM26. Among them, 22 patients (11 newly diagnosed and 11 posttherapy) underwent 68 Ga-BBN PET/CT for comparison within 1 wk. 99m Tc-MDP (methylene diphosphonate) bone scans were obtained within 2 wk for comparison. GRPR immunohistochemical staining of tumor samples was performed. Results: The administration of 68 Ga-M26 was well tolerated by all subjects, with no adverse symptoms being noticed or reported during the procedure and at 2-wk follow-up. The total effective dose equivalent and effective dose were 0.0912 ± 0.0140 and 0.0657 ± 0.0124 mSv/MBq, respectively. In the 17 patients with newly diagnosed prostate cancer, 68 Ga-RM26 PET/CT showed positive prostate-confined findings in 15 tumors with an SUV max of 6.49 ± 2.37. In the 11 patients who underwent prostatectomy or brachytherapy with or without androgen deprivation therapy, 68 Ga-RM26 PET/CT detected 8 metastatic lymph nodes in 3 patients with an SUV max of 4.28 ± 1.25 and 21 bone lesions in 8 patients with an SUV max of 3.90 ± 3.07. Compared with 68 Ga-RM26 PET/CT, GRPR agonist 68 Ga-BBN PET/CT detected fewer primary lesions and lymph node metastases as well as demonstrated lower tracer accumulation. There was a significant positive correlation between SUV derived from 68 Ga-RM26 PET and the expression level of GRPR ( P < 0.001). Conclusion: This study indicates the safety and significant efficiency of GRPR antagonist 68 Ga-RM26. 68 Ga-RM26 PET/CT would have remarkable value in detecting both primary prostate cancer and metastasis. 68 Ga-RM26 is also expected to be better than GRPR agonist as an imaging marker to evaluate GRPR expression in prostate cancer. © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

Nonuniform continuum model for solvatochromism based on frozen-density embedding theory.

PubMed

Shedge, Sapana Vitthal; Wesolowski, Tomasz A

2014-10-20

Frozen-density embedding theory (FDET) provides the formal framework for multilevel numerical simulations, such that a selected subsystem is described at the quantum mechanical level, whereas its environment is described by means of the electron density (frozen density; ${\\rho _{\\rm{B}} (\\vec r)}$). The frozen density ${\\rho _{\\rm{B}} (\\vec r)}$ is usually obtained from some lower-level quantum mechanical methods applied to the environment, but FDET is not limited to such choices for ${\\rho _{\\rm{B}} (\\vec r)}$. The present work concerns the application of FDET, in which ${\\rho _{\\rm{B}} (\\vec r)}$ is the statistically averaged electron density of the solvent ${\\left\\langle {\\rho _{\\rm{B}} (\\vec r)} \\right\\rangle }$. The specific solute-solvent interactions are represented in a statistical manner in ${\\left\\langle {\\rho _{\\rm{B}} (\\vec r)} \\right\\rangle }$. A full self-consistent treatment of solvated chromophore, thus involves a single geometry of the chromophore in a given state and the corresponding ${\\left\\langle {\\rho _{\\rm{B}} (\\vec r)} \\right\\rangle }$. We show that the coupling between the two descriptors might be made in an approximate manner that is applicable for both absorption and emission. The proposed protocol leads to accurate (error in the range of 0.05 eV) descriptions of the solvatochromic shifts in both absorption and emission. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26

PubMed Central

Thisgaard, Helge; Rosenström, Ulrika; Dam, Johan Hygum; Larhed, Mats

2017-01-01

High gastrin releasing peptide receptor (GRPR) expression is associated with numerous cancers including prostate and breast cancer. The aim of the current study was to develop a 55Co-labeled PET agent based on GRPR antagonist RM26 for visualization of GRPR-expressing tumors. Labeling with 57Co and 55Co, stability, binding specificity, and in vitro and in vivo characteristics of 57Co-NOTA-PEG2-RM26 were studied. NOTA-PEG2-RM26 was successfully radiolabeled with 57Co and 55Co with high yields and demonstrated high stability. The radiopeptide showed retained binding specificity to GRPR in vitro and in vivo. 57Co-NOTA-PEG2-RM26 biodistribution in mice was characterized by rapid clearance of radioactivity from blood and normal non-GRPR-expressing organs and low hepatic uptake. The clearance was predominantly renal with a low degree of radioactivity reabsorption. Tumor-to-blood ratios were approximately 200 (3 h pi) and 1000 (24 h pi). The favorable biodistribution of cobalt-labeled NOTA-PEG2-RM26 translated into high contrast preclinical PET/CT (using 55Co) and SPECT/CT (using 57Co) images of PC-3 xenografts. The initial biological results suggest that 55Co-NOTA-PEG2-RM26 is a promising tracer for PET visualization of GRPR-expressing tumors. PMID:29097932

A comparison of muscle activation between a Smith machine and free weight bench press.

PubMed

Schick, Evan E; Coburn, Jared W; Brown, Lee E; Judelson, Daniel A; Khamoui, Andy V; Tran, Tai T; Uribe, Brandon P

2010-03-01

The bench press exercise exists in multiple forms including the machine and free weight bench press. It is not clear though how each mode differs in its effect on muscle activation. The purpose of this study was to compare muscle activation of the anterior deltoid, medial deltoid, and pectoralis major during a Smith machine and free weight bench press at lower (70% 1 repetition maximum [1RM]) and higher (90% 1RM) intensities. Normalized electromyography amplitude values were used during the concentric phase of the bench press to compare muscle activity between a free weight and Smith machine bench press. Participants were classified as either experienced or inexperienced bench pressers. Two testing sessions were used, each of which entailed either all free weight or all Smith machine testing. In each testing session, each participant's 1RM was established followed by 2 repetitions at 70% of 1RM and 2 repetitions at 90% of 1RM. Results indicated greater activation of the medial deltoid on the free weight bench press than on the Smith machine bench press. Also, there was greater muscle activation at the 90% 1RM load than at the 70% 1RM load. The results of this study suggest that strength coaches should consider choosing the free weight bench press over the Smith machine bench press because of its potential for greater upper-body muscular development.

Regional climate engineering by radiation management: Prerequisites and prospects

NASA Astrophysics Data System (ADS)

Quaas, Johannes; Quaas, Martin F.; Boucher, Olivier; Rickels, Wilfried

2016-12-01

Radiation management (RM), as an option to engineer the climate, is highly controversial and suffers from a number of ethical and regulatory concerns, usually studied in the context of the objective to mitigate the global mean temperature. In this article, we discuss the idea that RM can be differentiated and scaled in several dimensions with potential objectives being to influence a certain climate parameter in a specific region. Some short-lived climate forcers (e.g., tropospheric aerosols) exhibit strong geographical and temporal variability, potentially leading to limited-area climate responses. Marine cloud brightening and thinning or dissolution of cirrus clouds could be operated at a rather local scale. It is therefore conceivable that such schemes could be applied with the objective to influence the climate at a regional scale. From a governance perspective, it is desirable to avoid any substantial climate effects of regional RM outside the target region. This, however, could prove impossible for a sustained, long-term RM. In turn, regional RM during limited time periods could prove more feasible without effects beyond the target area. It may be attractive as it potentially provides the opportunity to target the suppression of some extreme events such as heat waves. Research is needed on the traceability of regional RM, for example, using detection and attribution methods. Incentives and implications of regional RM need to be examined, and new governance options have to be conceived.

Programmable Liquid Crystal Elastomers Prepared by Thiol-Ene Photopolymerization (Postprint)

DTIC Science & Technology

2015-08-17

defect forms a 2D wrinkling pattern that leads to an areal contraction (Figure 4c,d). Both of these films return to a largely flat state on cooling...photopolymerization. ■ MATERIALS AND METHODS RM82 (1,4-bis-[4-(6-acryloyloxyhexyloxy)benzoyloxy]-2-methylben- zene) was purchased from Synthon Chemicals. 1,2...noted. Liquid crystal cells were prepared using methods described elsewhere.10 Briefly for cells patterned using rubbed surfaces, Elvamide was

Shear Bond Strength of Metal Brackets to Zirconia Conditioned with Various Primer-Adhesive Systems

DTIC Science & Technology

2016-07-01

Reynolds, 1979 ). Bonding orthodontic brackets to ceramic restorative materials poses a unique challenge. Abu et al. measured the strength between...forth by Reynolds and 34 others (Reynolds, 1979 ). The pertinent question is the following: should brackets be chemically bonded to zirconia...conditioned with a new silane coupling agent. Eur J Orthod. 2013 Feb;35(1):103-9. 40 Giannini M, Soares CJ, de Carvalho RM. Ultimate tensile

Temperature Compensation of Aluminum Nitride Lamb Wave Resonators Utilizing the Lowest-Order Symmetric Mode

DTIC Science & Technology

2012-12-14

PZT ceramic plate [40]. Since then Lamb wave devices utilizing the lowest-order antisymmetric (A0) mode propagation in ZnO thin plate were widely...Million Pt Platinum PVDF Polyvinylidene Flouride PZT Lead Zirconium Titanate Q Quality Factor R Resistor RIE Reactive Ion Etching Rm Motional...GaAs), silicon carbide (SiC), langasite (LGS), lead zirconium titanate ( PZT ), and polyvinylidene flouride (PVDF). Each piezoelectric material has

Nondestructive Evaluation Technology Working Group Report (IDA/OSD R&M (Institute for Defense Analyses/Office of the Secretary of Defense Reliability and Maintainability Study).

DTIC Science & Technology

1983-08-01

evaluating surface residual stresses in ferromagnetic materials, but until recently has - been considered too time consuming for production application. Fast...generic residual stress , X-ray, image processing, neutron processing, neutron radiography, vibrothermography, nuclear magnetic resonance 20. ABSTRACT...studied, this technology study effort would not have been possible within the time and resources available. P-3 i La

Nutraceutical Potential of New Alfalfa (Medicago sativa) Ingredients for Beverage Preparations.

PubMed

Soto-Zarazúa, Maria Guadalupe; Bah, Moustapha; Costa, Anabela Silvia Gomes; Rodrigues, Francisca; Pimentel, Filipa Botelho; Rojas-Molina, Isela; Rojas, Alejandra; Oliveira, Maria Beatriz Prior Pinto

2017-10-01

Alfalfa (Medicago sativa) has been extensively used as animal feed, due to its fiber, protein, minerals, and vitamins, being also a useful source of phenolic compounds with potential therapeutic benefits. Nevertheless, its potential use as human ingredient is scarce. The aim of this work was to assess the nutritional composition, amino acid profile, and antioxidant capacity (AOC) of freeze-dried juice (FDJ) and fibrous residual material (RM), two new alfalfa-derived products (Adps) recently launched as ingredients for beverage preparations. Results demonstrated a high content of proteins (23-30 g/100 g FDJ and 13-17 g/100 g RM), crude fiber (29 g/100 g RM), and minerals (such as sodium, calcium, iron, and zinc). No significant difference was found in caloric content (4 kcal/g). Essential and nonessential amino acids were quantified in both Adps being leucine and lysine the most abundant. Total phenolic and total flavonoid contents (TPC and TFC, respectively) and their changes along the different harvesting periods of the year were also examined. FDJ presented the highest TPC in May (19 mg gallic acid equivalents/g dry weight [dw]), while in October TFC had the maximum value (4 mg catechin equivalents/g dw). Both products exhibited an interesting AOC by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power assays. This study reports the nutraceutical potential of two new types of Adps.

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles

PubMed Central

Nandi, Tannistha; Holden, Matthew T.G.; Didelot, Xavier; Mehershahi, Kurosh; Boddey, Justin A.; Beacham, Ifor; Peak, Ian; Harting, John; Baybayan, Primo; Guo, Yan; Wang, Susana; How, Lee Chee; Sim, Bernice; Essex-Lopresti, Angela; Sarkar-Tyson, Mitali; Nelson, Michelle; Smither, Sophie; Ong, Catherine; Aw, Lay Tin; Hoon, Chua Hui; Michell, Stephen; Studholme, David J.; Titball, Richard; Chen, Swaine L.; Parkhill, Julian

2015-01-01

Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on 106 clinical, animal, and environmental strains from a restricted Asian locale. Whole-genome phylogenies resolved multiple genomic clades of Bp, largely congruent with multilocus sequence typing (MLST). We discovered widespread recombination in the Bp core genome, involving hundreds of regions associated with multiple haplotypes. Highly recombinant regions exhibited functional enrichments that may contribute to virulence. We observed clade-specific patterns of recombination and accessory gene exchange, and provide evidence that this is likely due to ongoing recombination between clade members. Reciprocally, interclade exchanges were rarely observed, suggesting mechanisms restricting gene flow between clades. Interrogation of accessory elements revealed that each clade harbored a distinct complement of restriction-modification (RM) systems, predicted to cause clade-specific patterns of DNA methylation. Using methylome sequencing, we confirmed that representative strains from separate clades indeed exhibit distinct methylation profiles. Finally, using an E. coli system, we demonstrate that Bp RM systems can inhibit uptake of non-self DNA. Our data suggest that RM systems borne on mobile elements, besides preventing foreign DNA invasion, may also contribute to limiting exchanges of genetic material between individuals of the same species. Genomic clades may thus represent functional units of genetic isolation in Bp, modulating intraspecies genetic diversity. PMID:25236617

78 FR 17394 - Filing via the Internet; Electronic Tariff Filings; Revisions to Electric Quarterly Report Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. RM07-16-000; RM01-5-000; RM12-3-000] Filing via the Internet; Electronic Tariff Filings; Revisions to Electric Quarterly Report Filing Process; Notice of Technical Conference Take notice that on April 16, 2013, the staff of the...

Angiotensin-Converting Enzyme Genotype and Arterial Oxygen Saturation at High Altitude in Peruvian Quechua

PubMed Central

Bigham, Abigail W.; Kiyamu, Melisa; León-Velarde, Fabiola; Parra, Esteban J.; Rivera-Ch, Maria; Shriver, Mark D.

2008-01-01

Abstract Bigham, Abigail W., Melisa Kiyamu, Fabiola León-Verlarde, Esteban J. Parra, Maria Rivera-Ch, Mark D. Shriver, and Tom D. Brutsaert. Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua. High Alt. Med. Biol. 9:167–178, 2008.—The I-allele of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been associated with performance benefits at high altitude (HA). In n = 142 young males and females of largely Quechua origins in Peru, we evaluated 3 specific hypotheses with regard to the HA benefits of the I-allele: (1) the I-allele is associated with higher arterial oxygen saturation (\\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$${\\rm Sa}_{\\rm O_2}$$\\end{document}) at HA, (2) the I-allele effect depends on the acclimatization state of the subjects, and (3) the putative I-allele effect on \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$${\\rm Sa}_{\\rm O_2}$$\\end{document} is mediated by the isocapnic hypoxic ventilatory response (HVR, \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$$1 / {\\rm min}^{- 1} / \\%{\\rm Sa}_{\\rm O_2}{- 1}$$\\end{document}). The subject participants comprised two different study groups including BLA subjects (born at low altitude) who were lifelong sea-level residents transiently exposed to hypobaric hypoxia (<24 h) and BHA subjects (born at HA) who were lifelong residents of HA. To control for the possibility of population stratification, Native American ancestry proportion (NAAP) was estimated as a covariate for each individual using a panel of 70 ancestry-informative molecular markers (AIMS). At HA, resting and exercise \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$${\\rm Sa}_{\\rm O_2}$$\\end{document} was strongly associated with the ACE genotype, p = 0.008 with ∼4% of the total variance in \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$${\\rm Sa}_{\\rm O_2}$$\\end{document} attributed to ACE genotype. Moreover, I/I individuals maintained ∼2.3 percentage point higher \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$${\\rm Sa}_{\\rm O_2}$$\\end{document} compared to I/D and D/D. This I-allele effect was evident in both BLA and BHA groups, suggesting that acclimatization state has little influence on the phenotypic expression of the ACE gene. Finally, ACE genotype was not associated with the isocapnic HVR, although HVR had a strong independent effect on \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$${\\rm Sa}_{\\rm O_2}$$\\end{document} (p = 0.001). This suggests that the I-allele effect on \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6}\\begin{document}$${\\rm Sa}_{\\rm O_2}$$\\end{document} is not mediated by the peripheral control of breathing, but rather by some other central cardiopulmonary effect of the ACE gene on the renin–angiotensin–aldosterone system (RAAS). PMID:18578648

Development of an Italian RM Y-STR haplotype database: Results of the 2013 GEFI collaborative exercise.

PubMed

Robino, C; Ralf, A; Pasino, S; De Marchi, M R; Ballantyne, K N; Barbaro, A; Bini, C; Carnevali, E; Casarino, L; Di Gaetano, C; Fabbri, M; Ferri, G; Giardina, E; Gonzalez, A; Matullo, G; Nutini, A L; Onofri, V; Piccinini, A; Piglionica, M; Ponzano, E; Previderè, C; Resta, N; Scarnicci, F; Seidita, G; Sorçaburu-Cigliero, S; Turrina, S; Verzeletti, A; Kayser, M

2015-03-01

Recently introduced rapidly mutating Y-chromosomal short tandem repeat (RM Y-STR) loci, displaying a multiple-fold higher mutation rate relative to any other Y-STRs, including those conventionally used in forensic casework, have been demonstrated to improve the resolution of male lineage differentiation and to allow male relative separation usually impossible with standard Y-STRs. However, large and geographically-detailed frequency haplotype databases are required to estimate the statistical weight of RM Y-STR haplotype matches if observed in forensic casework. With this in mind, the Italian Working Group (GEFI) of the International Society for Forensic Genetics launched a collaborative exercise aimed at generating an Italian quality controlled forensic RM Y-STR haplotype database. Overall 1509 male individuals from 13 regional populations covering northern, central and southern areas of the Italian peninsula plus Sicily were collected, including both "rural" and "urban" samples classified according to population density in the sampling area. A subset of individuals was additionally genotyped for Y-STR loci included in the Yfiler and PowerPlex Y23 (PPY23) systems (75% and 62%, respectively), allowing the comparison of RM and conventional Y-STRs. Considering the whole set of 13 RM Y-STRs, 1501 unique haplotypes were observed among the 1509 sampled Italian men with a haplotype diversity of 0.999996, largely superior to Yfiler and PPY23 with 0.999914 and 0.999950, respectively. AMOVA indicated that 99.996% of the haplotype variation was within populations, confirming that genetic-geographic structure is almost undetected by RM Y-STRs. Haplotype sharing among regional Italian populations was not observed at all with the complete set of 13 RM Y-STRs. Haplotype sharing within Italian populations was very rare (0.27% non-unique haplotypes), and lower in urban (0.22%) than rural (0.29%) areas. Additionally, 422 father-son pairs were investigated, and 20.1% of them could be discriminated by the whole set of 13 RM Y-STRs, which was very close to the theoretically expected estimate of 19.5% given the mutation rates of the markers used. Results obtained from a high-coverage Italian haplotype dataset confirm on the regional scale the exceptional ability of RM Y-STRs to resolve male lineages previously observed globally, and attest the unsurpassed value of RM Y-STRs for male-relative differentiation purposes. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Catalysis by Methylamine Dehydrogenase and Electron Transfer to Amicyanin and Cytochrome C(551I) from Paracoccus Denitrificans.

NASA Astrophysics Data System (ADS)

Brooks, Harold Burns

1995-01-01

The quinoprotein methylamine dehydrogenase (MADH), a type I copper protein, amicyanin, and cytochrome c _{55li} form a physiologic ternary complex (Chen et al. (1994) Science 264, 86-90) in which electrons are transferred from tryptophan tryptophylquinone to copper to heme. The reduction of MADH by rm H_3- and rm D_3 -methylamine, the reoxidation of MADH by amicyanin, and the reduction of cytochrome c_{55li } by reduced amicyanin in the presence of MADH have been studied by stopped-flow spectroscopy. When rm CD_3NH_2 was used as a substrate for MADH a deuterium kinetic isotope effect of 17.2 was measured for the hydrogen abstraction step. The maximum deuterium kinetic isotope effect that was measured in steady-state kinetic experiments was 3.0. The temperature dependencies of the rate constants for the reaction of methylamine with MADH were also determined. An iminosemiquinone intermediate for the oxidation of substrate-reduced MADH by amicyanin was detected using stopped-flow spectroscopy, and the presence of the substrate derived nitrogen was confirmed by electron spin echo envelope modulation (ESEEM) spectroscopy. Marcus theory, which was used to analyze the electron transfer reaction between the dithionite-generated redox forms of MADH and amicyanin, gave values of 218 kJ rm mol^{ -1} (2.3 eV) for the reorganizational energy (lambda ) and 11.6 rm cm^{-1} for the coupling rm (H_{AB}). In contrast, the oxidation of substrate-reduced MADH by amicyanin was a gated electron transfer reaction with values for DeltaH* of 76 kJ rm mol^ {-1} and DeltaS* of -41 J rm mol^{ -1} ^circ K^ {-1}. These studies are consistent with the formation of transient unstable intermediates preceeding electron transfer between MADH and amicyanin. Preliminary investigations of the ternary complex of MADH, amicyanin, and cytochrome c_{55li } suggest two distinct cytochrome c _{55li} binding sites on amicyanin. This conclusion is supported by the biphasic nature of the stopped -flow trace, the inhibition of the rm k^ {fast}_{obs} by MADH, and the ionic strength dependence of the two phases. The slow phase had a rate of 3.1 rm s^ {-1} which is consistent with electron transfer between amicyanin and cytochrome c_ {55li} within the ternary complex. The fast phase does not exhibit saturation behavior, must have an electron transfer rate greater than 1000 rm s^{-1}, and likely involves a complex of amicyanin and cytochrome c_{55li } near the hydrophobic patch of amicyanin.

Microwave Dissipation due to Vortices in High - Superconductors

NASA Astrophysics Data System (ADS)

Anand, Niraj

1995-01-01

Using meander line resonant structures, we perform highly sensitive measurements of the changes in surface resistance Delta R_{s} of Y{rm Ba}_{2} {rm Cu}_{3}{rm O }_{rm 7-x} thin films in order to probe vortex dynamics as a function of temperature, applied dc magnetic field (H), and angle (theta) of the applied field relative to the ab planes. In our experiments, we observe that the component of the magnetic field normal to the ab planes produces substantially more dissipation than the component parallel to the ab planes. By using an extension of the London theory to anisotropic superconductors, we can calculate the internal flux densities parallel (B_{ab}) and perpendicular (B_{c}) to the ab planes inside a superconductor for an arbitrary field orientation relative to the ab planes. For low fields, we can define a weight (delta) of the relative contribution to dissipation from B _{ab} relative to that from B _{c}. This allows us to calculate an "effective internal flux density and hence obtain the total dissipation. Using the results from this theory, we obtain excellent quantitative agreement with our measurements of Delta R_{s} vs. theta. This is only possible if we take into account both the anisotropic screening and the anisotropic response of the material. We have also measured the magnetic field dependence of dissipation for fields applied at shallow angles from the ab planes. Here we observe two regions of markedly different dissipation separated by a temperature dependent crossover field H_{cr}(T). For H>H_{cr}(T) we observe a strong linear dependence of Delta R_ {s} vs. H. For HH_{cr}(T)]. . We have also measured thermally activated motion of field-induced vortices in a uniform lattice of pinning sites produced by selectively removing superconducting island from a 1000times1000 array of proximity-effect Josephson junctions. Such a defect array can serve as a "model" system for studying pinning in granular materials such as the high-T_ {c} superconductors.

Performance comparison of two resolution modeling PET reconstruction algorithms in terms of physical figures of merit used in quantitative imaging.

PubMed

Matheoud, R; Ferrando, O; Valzano, S; Lizio, D; Sacchetti, G; Ciarmiello, A; Foppiano, F; Brambilla, M

2015-07-01

Resolution modeling (RM) of PET systems has been introduced in iterative reconstruction algorithms for oncologic PET. The RM recovers the loss of resolution and reduces the associated partial volume effect. While these methods improved the observer performance, particularly in the detection of small and faint lesions, their impact on quantification accuracy still requires thorough investigation. The aim of this study was to characterize the performances of the RM algorithms under controlled conditions simulating a typical (18)F-FDG oncologic study, using an anthropomorphic phantom and selected physical figures of merit, used for image quantification. Measurements were performed on Biograph HiREZ (B_HiREZ) and Discovery 710 (D_710) PET/CT scanners and reconstructions were performed using the standard iterative reconstructions and the RM algorithms associated to each scanner: TrueX and SharpIR, respectively. RM determined a significant improvement in contrast recovery for small targets (≤17 mm diameter) only for the D_710 scanner. The maximum standardized uptake value (SUVmax) increased when RM was applied using both scanners. The SUVmax of small targets was on average lower with the B_HiREZ than with the D_710. Sharp IR improved the accuracy of SUVmax determination, whilst TrueX showed an overestimation of SUVmax for sphere dimensions greater than 22 mm. The goodness of fit of adaptive threshold algorithms worsened significantly when RM algorithms were employed for both scanners. Differences in general quantitative performance were observed for the PET scanners analyzed. Segmentation of PET images using adaptive threshold algorithms should not be undertaken in conjunction with RM reconstructions. Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Rationale and design of the MONITOR-ICD study: a randomized comparison of economic and clinical effects of automatic remote MONITORing versus control in patients with Implantable Cardioverter Defibrillators.

PubMed

Zabel, Markus; Müller-Riemenschneider, Falk; Geller, J Christoph; Brachmann, Johannes; Kühlkamp, Volker; Dissmann, Rüdiger; Reinhold, Thomas; Roll, Stephanie; Lüthje, Lars; Bode, Frank; Eckardt, Lars; Willich, Stefan N

2014-10-01

Implantable cardioverter defibrillator (ICD) remote follow-up and ICD remote monitoring (RM) are established means of ICD follow-up. The reduction of the number of in-office visits and the time to decision is proven, but the true clinical benefit is still unknown. Cost and cost-effectiveness of RM remain leading issues for its dissemination. The MONITOR-ICD study has been designed to assess costs, cost-effectiveness, and clinical benefits of RM versus standard-care follow-up in a prospective multicenter randomized controlled trial. Patients indicated for single- or dual-chamber ICD are eligible for the study and are implanted an RM-capable Biotronik ICD (Lumax VR-T or Lumax DR-T; Biotronik SE & Co KG, Berlin, Germany). Implantable cardioverter defibrillator programming and alert-based clinical responses in the RM group are highly standardized by protocol. As of December 2011, recruitment has been completed, and 416 patients have been enrolled. Subjects are followed-up for a minimum of 12months and a maximum of 24months, ending in January 2013. Disease-specific costs from a societal perspective have been defined as primary end point and will be compared between RM and standard-care groups. Secondary end points include ICD shocks (including appropriate and inappropriate shocks), cardiovascular hospitalizations and cardiovascular mortality, and additional health economic end points. The MONITOR-ICD study will be an important randomized RM study to report data on a primary economic end point in 2014. Its results on ICD shocks will add to the currently available evidence on clinical benefit of RM. Copyright © 2014 Mosby, Inc. All rights reserved.

Comparison of concentric and eccentric bench press repetitions to failure.

PubMed

Kelly, Stephen B; Brown, Lee E; Hooker, Steven P; Swan, Pamela D; Buman, Matthew P; Alvar, Brent A; Black, Laurie E

2015-04-01

Eccentric muscle actions (ECC) are characterized by muscle lengthening, despite actin-myosin crossbridge formation. Muscles acting eccentrically are capable of producing higher levels of force compared with muscles acting concentrically. The purpose of this study was to determine whether ECC bench press yields greater strength than concentric (CON) as determined by 1 repetition maximum (1RM). Additionally, a comparison was made examining differences in the number of repetitions to failure at different relative intensities of 1RM. Thirty healthy men (age = 24.63 ± 5.6 years) were tested for 1RM in CON and ECC bench press and the number of repetitions completed at 60, 70, 80, and 90% 1RM. For CON repetitions, the weight was mechanically lowered to the chest, and the participant pressed it up until the elbows were fully extended. The ECC bench press consisted of lowering a barbell from a fully extended elbow position to the chest in a continuous controlled manner for 3 seconds as determined by electronic metronome. Paired t-tests showed that ECC 1RM (115.99 ± 31.08 kg) was significantly (p ≤ 0.05) greater than CON 1RM (93.56 ± 26.56 kg), and the number of repetitions completed at 90% 1RM was significantly (p ≤ 0.05) greater in ECC (7.67 ± 3.24) as compared with CON (4.57 ± 2.21). There were no significant differences in number of completed repetitions during CON and ECC bench press at 60, 70, and 80% 1RM. These data indicate that ECC actions yield increased force capabilities (∼120%) as compared with CON in the bench press and may be less prone to fatigue, especially at higher intensities. These differences suggest a need to develop unique strategies for training eccentrically.

The influence of somatotype on anaerobic performance

PubMed Central

Faulkner, James; Jobson, Simon

2018-01-01

The link between athlete physique and performance in sports is well established. However, a direct link between somatotype three-numeral rating and anaerobic performance has not yet been reported. The purpose of this study was to assess the relations between somatotype and anaerobic performance using both singular and multivariate analyses. Thirty-six physically active males (mean ± standard deviation age 26.0 ± 9.8 years; body mass 79.5 ± 12.9 kg; height 1.82 ± 0.07 m) were somatotype-rated using the Heath-Carter method. Subjects were assessed for 3 repetition maximum (3 RM) bench press and back squat, and completed a 30-second maximal sprint cycle test. Positive correlations were observed between mesomorphy and 3 RM bench press (r = 0.560, p < 0.001), mesomorphy and 3 RM back squat (r = 0.550, p = 0.001) and between mesomorphy and minimum power output (r = 0.357, p = 0.033). Negative correlations were observed between ectomorphy and 3 RM bench press (r = -0.381, p = 0.022), and ectomorphy and 3 RM back squat (r = -0.336, p = 0.045). Individual regression analysis indicated that mesomorphy was the best predictor of 3 RM bench press performance, with 31.4% of variance in 3 RM bench press performance accounted for by the mesomorphy rating (p < 0.001). A combination of mesomorphy and ectomorphy best predicted 3 RM back squat performance (R2 = 0.388, p < 0.04). Around one third of strength performance is predicted by somatotype-assessed physique in physically active males. This could have important implications for the identification of those predisposed to perform well in sports containing strength-based movements and prescription of training programmes. PMID:29787610

The influence of somatotype on anaerobic performance.

PubMed

Ryan-Stewart, Helen; Faulkner, James; Jobson, Simon

2018-01-01

The link between athlete physique and performance in sports is well established. However, a direct link between somatotype three-numeral rating and anaerobic performance has not yet been reported. The purpose of this study was to assess the relations between somatotype and anaerobic performance using both singular and multivariate analyses. Thirty-six physically active males (mean ± standard deviation age 26.0 ± 9.8 years; body mass 79.5 ± 12.9 kg; height 1.82 ± 0.07 m) were somatotype-rated using the Heath-Carter method. Subjects were assessed for 3 repetition maximum (3 RM) bench press and back squat, and completed a 30-second maximal sprint cycle test. Positive correlations were observed between mesomorphy and 3 RM bench press (r = 0.560, p < 0.001), mesomorphy and 3 RM back squat (r = 0.550, p = 0.001) and between mesomorphy and minimum power output (r = 0.357, p = 0.033). Negative correlations were observed between ectomorphy and 3 RM bench press (r = -0.381, p = 0.022), and ectomorphy and 3 RM back squat (r = -0.336, p = 0.045). Individual regression analysis indicated that mesomorphy was the best predictor of 3 RM bench press performance, with 31.4% of variance in 3 RM bench press performance accounted for by the mesomorphy rating (p < 0.001). A combination of mesomorphy and ectomorphy best predicted 3 RM back squat performance (R2 = 0.388, p < 0.04). Around one third of strength performance is predicted by somatotype-assessed physique in physically active males. This could have important implications for the identification of those predisposed to perform well in sports containing strength-based movements and prescription of training programmes.

Evaluating the Past, Present, and Future of Regenerative Medicine: A Global View.

PubMed

Ronfard, Vincent; Vertès, Alain A; May, Michael H; Dupraz, Anne; van Dyke, Mark E; Bayon, Yves

2017-04-01

"Evaluating the Past and Present of Regenerative Medicine (RM)" was the first part of an Industry Symposium dedicated to the subject during the 2015 TERMIS World Congress in Boston. This working session presented a critical review of the current RM landscape in Europe and North America with possible projections for the future. Interestingly, the RM development cycle seems to obey the Gartner hype cycle, now at the enlightenment phase, after past exaggerated expectations and discouragements, as suggested by increasing numbers of clinical trials and recent market approvals of RM solutions in both Europe (Glybera and Holoclar ® from Chiesi Pharma and Strimvelis ® from GSK) and Japan (Remestemcel-L from Mesoblast ® ). The successful commercial translation of RM research is governed by five major drivers: (i) fully validated manufacturing capability for autologous or allogeneic products, (ii) reimbursement for targeted clinical indications with high and demonstrable medico-economic benefits versus standard of care, (iii) implication of regulatory bodies in the design and development plan of any RM solution, which should be well characterized, robust, with proven consistent efficacy and an acceptable and controlled positive benefit/risk ratio, (iv) collaborations facilitated by multicompetence hubs/consortia of excellence, (v) well-thought-out clinical development plans for reducing the risk of failure. Benefiting from past and present experience, the RM burgeoning industry is expected to accelerate the market release of cost-effective RM products with real curative potential for specific clinical indications with high unmet needs. This should be achieved by wisely leveraging all possible synergies of the different stakeholders, for example, patients, clinicians, reimbursement and health technology assessment (HTA) agencies, regulatory authorities, public/private investors, academia, and companies.

Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats

PubMed Central

2012-01-01

Background Recurrent/moderate (R/M) hypoglycemia is common in type 1 diabetes. Although mild or moderate hypoglycemia is not life-threatening, if recurrent, it may cause cognitive impairment. In the present study, we sought to determine whether R/M hypoglycemia leads to neuronal death, dendritic injury, or cognitive impairment. Methods The experiments were conducted in normal and in diabetic rats. Rats were subjected to moderate hypoglycemia by insulin without anesthesia. Oxidative stress was evaluated by 4-Hydroxy-2-nonenal immunostaining and neuronal death was determined by Fluoro-Jade B staining 7 days after R/M hypoglycemia. To test whether oxidative injury caused by NADPH oxidase activation, an NADPH oxidase inhibitor, apocynin, was used. Cognitive function was assessed by Barnes maze and open field tests at 6 weeks after R/M hypoglycemia. Results The present study found that oxidative injury was detected in the dendritic area of the hippocampus after R/M hypoglycemia. Sparse neuronal death was found in the cortex, but no neuronal death was detected in the hippocampus. Significant cognitive impairment and thinning of the CA1 dendritic region was detected 6 weeks after hypoglycemia. Oxidative injury, cognitive impairment, and hippocampal thinning after R/M hypoglycemia were more severe in diabetic rats than in non-diabetic rats. Oxidative damage in the hippocampal CA1 dendritic area and microglial activation were reduced by the NADPH oxidase inhibitor, apocynin. Conclusion The present study suggests that oxidative injury of the hippocampal CA1 dendritic region by R/M hypoglycemia is associated with chronic cognitive impairment in diabetic patients. The present study further suggests that NADPH oxidase inhibition may prevent R/M hypoglycemia-induced hippocampal dendritic injury. PMID:22830525

Effect of Different Interrepetition Rest Periods on Barbell Velocity Loss During the Ballistic Bench Press Exercise.

PubMed

García-Ramos, Amador; Padial, Paulino; Haff, G Gregory; Argüelles-Cienfuegos, Javier; García-Ramos, Miguel; Conde-Pipó, Javier; Feriche, Belén

2015-09-01

This study investigated the effect of introducing different interrepetition rest (IRR) periods on the ability to sustain maximum bench press throw velocity with a range of loads commonly used to develop upper-body power. Thirty-four physically active collegiate men (age: 21.5 ± 2.8 years; body mass: 75.2 ± 7.2 kg; height: 176.9 ± 4.9 cm) were tested during 2 consecutive weeks. During the first week, the maximum dynamic strength (repetition maximum [RM]) in bench press exercise was determined (RM = 76.7 ± 13.2 kg). The following week, 3 testing sessions were conducted with 48 hours apart in random order. In each day of evaluation, only 1 load (30%RM, 40%RM, or 50%RM) was assessed in the bench press throw exercise. With each load, subjects performed 3 single sets of 15 repetitions (15-minute interset rest) with 3 different sets configurations: continuous repetitions (CR), 6 seconds of IRR (IRR6), and 12 seconds of IRR (IRR12). The decrease of peak velocity (PV) was significantly lower for IRR12 compared with CR and IRR6 at least since the repetition 4. No differences between CR and IRR6 protocols were found until the repetition 7 at 30%RM and 40%RM and until the repetition 5 at 50%RM. The decrease of PV during the CR protocol was virtually linear for the 3 loads analyzed (r > 0.99); however, this linear relationship became weaker for IRR6 (r = 0.79-0.95) and IRR12 (r = 0.35-0.87). These results demonstrate that IRR periods allow increasing the number of repetitions before the onset of significant velocity losses.

Predicting maximal strength of quadriceps from submaximal performance in individuals with knee joint osteoarthritis.

PubMed

McNair, Peter J; Colvin, Matt; Reid, Duncan

2011-02-01

To compare the accuracy of 12 maximal strength (1-repetition maximum [1-RM]) equations for predicting quadriceps strength in people with osteoarthritis (OA) of the knee joint. Eighteen subjects with OA of the knee joint attended a rehabilitation gymnasium on 3 occasions: 1) a familiarization session, 2) a session where the 1-RM of the quadriceps was established using a weights machine for an open-chain knee extension exercise and a leg press exercise, and 3) a session where the subjects performed with a load at which they could lift for approximately 10 repetitions only. The data were used in 12 prediction equations to calculate 1-RM strength and compared to the actual 1-RM data. Data were examined using Bland and Altman graphs and statistics, intraclass correlation coefficients (ICCs), and typical error values between the actual 1-RM and the respective 1-RM prediction equation data. Difference scores (predicted 1-RM--actual 1-RM) across the injured and control legs were also compared. For the knee extension exercise, the Brown, Brzycki, Epley, Lander, Mayhew et al, Poliquin, and Wathen prediction equations demonstrated the greatest levels of predictive accuracy. All of the ICCs were high (range 0.96–0.99), and typical errors were between 3% and 4%. For the knee press exercise, the Adams, Berger, Kemmler et al, and O'Conner et al equations demonstrated the greatest levels of predictive accuracy. All of the ICCs were high (range 0.95-0.98), and the typical errors ranged from 5.9-6.3%. This study provided evidence supporting the use of prediction equations to assess maximal strength in individuals with a knee joint with OA.

Optimal load for the peak power and maximal strength of the upper body in Brazilian Jiu-Jitsu athletes.

PubMed

da Silva, Bruno Victor C; Simim, Mário A de Moura; Marocolo, Moacir; Franchini, Emerson; da Mota, Gustavo R

2015-06-01

We determined the optimal load for the peak power output (PPO) during the bench press throw (BPT) in Brazilian Jiu-Jitsu (BJJ) athletes and compared the PPO and maximal strength between advanced (AD) and nonadvanced (NA) athletes. Twenty-eight BJJ athletes (24.8 ± 5.7 years) performed the BPT at loads of 30, 40, 50, and 60% of their 1 repetition maximum (RM) in a randomized order (5-minute rest between BPTs). The PPO was determined by measuring the barbell displacement by an accelerometer (Myotest). The absolute (F = 7.25; p < 0.001; effect size [ES] = 0.21) and relative intensities were different (F = 7.11; p < 0.001; ES = 0.21) between the AD and NA. There was also a group and intensity interaction effect (F = 2.79; p = 0.046; ES = 0.10), but the differences were centered around the AD group, which achieved higher values using 40% (p = 0.001) and 50% of the 1RM (p < 0.001) than the PPO with 60% of 1RM. The AD athletes presented with higher 1RM than NA (p ≤ 0.05; ES = 1.0), but there was no difference (p > 0.05) in the PPO (30-60% 1RM). A polynomial adjustment indicated that the optimal load was ∼42% of 1RM for all groups and subgroups (R from 0.82 to 0.99). Our results suggest that there can be (1RM) differences between AD and NA BJJ athletes; however, there is no difference in the muscle power between the AD and NA groups. Additionally, ∼42% of 1RM seems to be the optimal load for developing maximal power using the BPT for the BJJ athletes.

The population dynamics of bacteria, phage and RM Systems

NASA Astrophysics Data System (ADS)

Guet, Calin; Levin, Bruce; Pleska, Maros

Viruses drive and mediate bacterial evolution as parasites and vectors of horizontal gene transfer, respectively. Temperate bacteriophages, defined by the ability to lysogenize a fraction of hosts and to transmit horizontally as well as vertically in the form of prophages, frequently carry genes that increase fitness or contribute to bacterial pathogenicity. Restriction-modification (RM) systems, which are widely diverse and ubiquitous among bacteria, can prevent infections leading to lysis, but their effect on lysogeny is not clear. We show that RM systems prevent lytic and lysogenic infections to the same extent and therefore represent a molecular barrier to prophage acquisition. Surprisingly, we find that this negative effect can be overcome and even reversed at the population level, as a consequence of dynamic interactions between viruses, hosts and RM systems. Thus the population dynamics of bacteria carrying RM systems impacts bacterial genome-wide evolution. .