Spatially extended K Iλ7699 emission in the nebula of VY CMa: kinematics and geometry

NASA Astrophysics Data System (ADS)

Smith, Nathan

2004-04-01

Long-slit echelle spectra reveal bright extended emission from the K Iλ7699 resonance line in the reflection nebula surrounding the extreme red supergiant VY Canis Majoris. The central star has long been known for its unusually bright K I emission lines, but this is the first report of intrinsic emission from K I in the nebula. The extended emission is not just a reflected spectrum of the star, but is due to resonant scattering by K atoms in the outer nebula itself, and is therefore a valuable probe of the kinematics and geometry of the circumstellar environment of VY CMa. Dramatic velocity structure is seen in the long-slit spectra, and most lines of sight through the nebula intersect multiple distinct velocity components. A faint `halo' at large distances from the star does appear to show a reflected spectrum, however, and suggests a systemic velocity of +40 km s-1 with respect to the Sun. The most striking feature is blueshifted emission from the filled interior of a large shell seen in images; the kinematic structure is reminiscent of a Hubble flow, and provides strong evidence for asymmetric and episodic mass loss due to localized eruptions on the stellar surface.

Spectroscopy and CCD-photography of extended red emission in reflection nebulae

NASA Technical Reports Server (NTRS)

Witt, A. N.; Schild, R. E.

1986-01-01

Recent spectrographic studies of extended red emission (ERE) seen in the 0.6 to 0.9 micron spectral region in many reflection nebulae have shown fluorescence by amorphous hydrogenated carbon to be the most probable cause of the ERE. Spectrographic observations were performed on the nebulae NGC 2023 and NGC 7023, using the intensified Reticon scanner (IRS) of Kitt Peak National Observatory on the N0-2 0.9 mm telescope. Charge coupled device (CCD) images of NGC2023 and NGC 7023 were obtained with the CfA CCD detector on the 0.6 mm telescope of the Whipple Observatory. Results are discussed.

Waiting in the Wings: Reflected X-ray Emission from the Homunculus Nebula

NASA Technical Reports Server (NTRS)

Corcoran, M. F.; Hamaguchi, K.; Gull, T.; Davidson, K.; Petre, R.; Hillier, D. J.; Smith, N.; Damineli, A.; Morse, J. A.; Walborn, N. R.

2004-01-01

We report the first detection of X-ray emission associated with the Homunculus Nebula which surrounds the supermassive star eta Carinae. The emission is characterized by a temperature in excess of 100 MK, and is consistent with scattering of the time-delayed X-ray flux associated with the star. The nebular emission is bright in the northwestern lobe and near the central regions of the Homunculus, and fainter in the southeastern lobe. We also report the detection of an unusually broad Fe K fluorescent line, which may indicate fluorescent scattering off the wind of a companion star or some other high velocity outflow. The X-ray Homunculus is the nearest member of the small class of Galactic X-ray reflection nebulae, and the only one in which both the emitting and reflecting sources are distinguishable.

Convection-enhanced Delivery of Therapeutics for Malignant Gliomas.

PubMed

Saito, Ryuta; Tominaga, Teiji

2017-01-15

Convection-enhanced delivery (CED) circumvents the blood-brain barrier by delivering agents directly into the tumor and surrounding parenchyma. CED can achieve large volumes of distribution by continuous positive-pressure infusion. Although promising as an effective drug delivery method in concept, the administration of therapeutic agents via CED is not without challenges. Limitations of distribution remain a problem in large brains, such as those of humans. Accurate and consistent delivery of an agent is another challenge associated with CED. Similar to the difficulties caused by immunosuppressive environments associated with gliomas, there are several mechanisms that make effective local drug distribution difficult in malignant gliomas. In this review, methods for local drug application targeting gliomas are discussed with special emphasis on CED. Although early clinical trials have failed to demonstrate the efficacy of CED against gliomas, CED potentially can be a platform for translating the molecular understanding of glioblastomas achieved in the laboratory into effective clinical treatments. Several clinical studies using CED of chemotherapeutic agents are ongoing. Successful delivery of effective agents should prove the efficacy of CED in the near future.

Convection-enhanced Delivery of Therapeutics for Malignant Gliomas

PubMed Central

SAITO, Ryuta; TOMINAGA, Teiji

2017-01-01

Convection-enhanced delivery (CED) circumvents the blood–brain barrier by delivering agents directly into the tumor and surrounding parenchyma. CED can achieve large volumes of distribution by continuous positive-pressure infusion. Although promising as an effective drug delivery method in concept, the administration of therapeutic agents via CED is not without challenges. Limitations of distribution remain a problem in large brains, such as those of humans. Accurate and consistent delivery of an agent is another challenge associated with CED. Similar to the difficulties caused by immunosuppressive environments associated with gliomas, there are several mechanisms that make effective local drug distribution difficult in malignant gliomas. In this review, methods for local drug application targeting gliomas are discussed with special emphasis on CED. Although early clinical trials have failed to demonstrate the efficacy of CED against gliomas, CED potentially can be a platform for translating the molecular understanding of glioblastomas achieved in the laboratory into effective clinical treatments. Several clinical studies using CED of chemotherapeutic agents are ongoing. Successful delivery of effective agents should prove the efficacy of CED in the near future. PMID:27980285

Radiation exposure from diagnostic imaging in young patients with testicular cancer.

PubMed

Sullivan, C J; Murphy, K P; McLaughlin, P D; Twomey, M; O'Regan, K N; Power, D G; Maher, M M; O'Connor, O J

2015-04-01

Risks associated with high cumulative effective dose (CED) from radiation are greater when imaging is performed on younger patients. Testicular cancer affects young patients and has a good prognosis. Regular imaging is standard for follow-up. This study quantifies CED from diagnostic imaging in these patients. Radiological imaging of patients aged 18-39 years, diagnosed with testicular cancer between 2001 and 2011 in two tertiary care centres was examined. Age at diagnosis, cancer type, dose-length product (DLP), imaging type, and frequency were recorded. CED was calculated from DLP using conversion factors. Statistical analysis was performed with SPSS. In total, 120 patients with a mean age of 30.7 ± 5.2 years at diagnosis had 1,410 radiological investigations. Median (IQR) surveillance was 4.37 years (2.0-5.5). Median (IQR) CED was 125.1 mSv (81.3-177.5). Computed tomography accounted for 65.3 % of imaging studies and 98.3 % of CED. We found that 77.5 % (93/120) of patients received high CED (>75 mSv). Surveillance time was associated with high CED (OR 2.1, CI 1.5-2.8). Survivors of testicular cancer frequently receive high CED from diagnostic imaging, mainly CT. Dose management software for accurate real-time monitoring of CED and low-dose CT protocols with maintained image quality should be used by specialist centres for surveillance imaging. • CT accounted for 98.3 % of CED in patients with testicular cancer. • Median CED in patients with testicular cancer was 125.1 mSv • High CED (>75 mSv) was observed in 77.5 % (93/120) of patients. • Dose tracking and development of low-dose CT protocols are recommended.

Self-reported dietary adherence, disease-specific symptoms, and quality of life are associated with healthcare provider follow-up in celiac disease.

PubMed

Hughey, Jacob J; Ray, Bonnie K; Lee, Anne R; Voorhees, Kristin N; Kelly, Ciaran P; Schuppan, Detlef

2017-12-11

The only treatment for celiac disease (CeD) is a lifelong gluten-free diet (GFD). The restrictive nature of the GFD makes adherence a challenge. As an integral part of CeD management, multiple professional organizations recommend regular follow-up with a healthcare provider (HCP). Many CeD patients also participate in patient advocacy groups (PAGs) for education and support. Previous work found that follow-up of CeD patients is highly variable. Here we investigated the self-reported factors associated with HCP follow-up among individuals diagnosed with CeD who participate in a PAG. We conducted a survey of members of Beyond Celiac (a PAG), collecting responses from 1832 U.S. adults ages 19-65 who reported having CeD. The survey queried HCP follow-up related to CeD and included validated instruments for dietary adherence (CDAT), disease-specific symptoms (CSI), and quality of life (CD-QOL). Overall, 27% of respondents diagnosed with CeD at least five years ago reported that they had not visited an HCP about CeD in the last five years. The most frequent reason for not visiting an HCP was "doing fine on my own" (47.6%). Using multiple logistic regression, we identified significant associations between whether a respondent reported visiting an HCP about CeD in the last five years and the scores for all three validated instruments. In particular, as disease-specific symptoms and quality of life worsened, the probability of having visited an HCP increased. Conversely, as dietary adherence worsened, the probability decreased. Our results suggest that many individuals with CeD manage their disease without ongoing support from an HCP. Our results thus emphasize the need for greater access to high quality CeD care, and highlight an opportunity for PAGs to bring together patients and HCPs to improve management of CeD.

Memory and Coping with Stress: The Relationship Between Cognitive-Emotional Distinctiveness, Memory Valence, and Distress

PubMed Central

Boals, Adriel; Rubin, David C.; Klein, Kitty

2011-01-01

Cognitive-emotional distinctiveness (CED), the extent to which an individual separates emotions from an event in the cognitive representation of the event, was explored in four studies. CED was measured using a modified multidimensional scaling procedure. The first study found that lower levels of CED in memories of the September 11 terrorist attacks predicted greater frequency of intrusive thoughts about the attacks. The second study revealed CED levels are higher in negative events, in comparison to positive events and that low CED levels in emotionally intense negative events are associated with a pattern of greater event-related distress. The third study replicated the findings from the previous study when examining CED levels in participants’ memories of the 2004 Presidential election. The fourth study revealed that low CED in emotionally intense negative events is associated with worse mental health. We argue that CED is an adaptive and healthy coping feature of stressful memories. PMID:18569690

Probabilistic evaluation of on-line checks in fault-tolerant multiprocessor systems

NASA Technical Reports Server (NTRS)

Nair, V. S. S.; Hoskote, Yatin V.; Abraham, Jacob A.

1992-01-01

The analysis of fault-tolerant multiprocessor systems that use concurrent error detection (CED) schemes is much more difficult than the analysis of conventional fault-tolerant architectures. Various analytical techniques have been proposed to evaluate CED schemes deterministically. However, these approaches are based on worst-case assumptions related to the failure of system components. Often, the evaluation results do not reflect the actual fault tolerance capabilities of the system. A probabilistic approach to evaluate the fault detecting and locating capabilities of on-line checks in a system is developed. The various probabilities associated with the checking schemes are identified and used in the framework of the matrix-based model. Based on these probabilistic matrices, estimates for the fault tolerance capabilities of various systems are derived analytically.

CEDS Addresses: Rubric Elements

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

Common Education Data Standards (CEDS) Version 4 introduced a common data vocabulary for defining rubrics in a data system. The CEDS elements support digital representations of both holistic and analytic rubrics. This document shares examples of holistic and analytic project rubrics, available CEDS Connections, and a logical model showing the…

Infrared images of reflection nebulae and Orion's bar: Fluorescent molecular hydrogen and the 3.3 micron feature

NASA Technical Reports Server (NTRS)

Burton, Michael G.; Moorhouse, Alan; Brand, P. W. J. L.; Roche, Patrick F.; Geballe, T. R.

1989-01-01

Images were obtained of the (fluorescent) molecular hydrogen 1-0 S(1) line, and of the 3.3 micron emission feature, in Orion's Bar and three reflection nebulae. The emission from these species appears to come from the same spatial locations in all sources observed. This suggests that the 3.3 micron feature is excited by the same energetic UV-photons which cause the molecular hydrogen to fluoresce.

Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans

PubMed Central

Neukomm, L J; Zeng, S; Frei, A P; Huegli, P A; Hengartner, M O

2014-01-01

The rapid clearance of dying cells is important for the well-being of multicellular organisms. In C. elegans, cell corpse removal is mainly mediated by three parallel engulfment signaling cascades. These pathways include two small GTPases, MIG-2/RhoG and CED-10/Rac1. Here we present the identification and characterization of CDC-42 as a third GTPase involved in the regulation of cell corpse clearance. Genetic analyses performed by both loss of cdc-42 function and cdc-42 overexpression place cdc-42 in parallel to the ced-2/5/12 signaling module, in parallel to or upstream of the ced-10 module, and downstream of the ced-1/6/7 module. CDC-42 accumulates in engulfing cells at membranes surrounding apoptotic corpses. The formation of such halos depends on the integrins PAT-2/PAT-3, UNC-112 and the GEF protein UIG-1, but not on the canonical ced-1/6/7 or ced-2/5/12 signaling modules. Together, our results suggest that the small GTPase CDC-42 regulates apoptotic cell engulfment possibly upstream of the canonical Rac GTPase CED-10, by polarizing the engulfing cell toward the apoptotic corpse in response to integrin signaling and ced-1/6/7 signaling in C. elegans. PMID:24632947

Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans.

PubMed

Neukomm, L J; Zeng, S; Frei, A P; Huegli, P A; Hengartner, M O

2014-06-01

The rapid clearance of dying cells is important for the well-being of multicellular organisms. In C. elegans, cell corpse removal is mainly mediated by three parallel engulfment signaling cascades. These pathways include two small GTPases, MIG-2/RhoG and CED-10/Rac1. Here we present the identification and characterization of CDC-42 as a third GTPase involved in the regulation of cell corpse clearance. Genetic analyses performed by both loss of cdc-42 function and cdc-42 overexpression place cdc-42 in parallel to the ced-2/5/12 signaling module, in parallel to or upstream of the ced-10 module, and downstream of the ced-1/6/7 module. CDC-42 accumulates in engulfing cells at membranes surrounding apoptotic corpses. The formation of such halos depends on the integrins PAT-2/PAT-3, UNC-112 and the GEF protein UIG-1, but not on the canonical ced-1/6/7 or ced-2/5/12 signaling modules. Together, our results suggest that the small GTPase CDC-42 regulates apoptotic cell engulfment possibly upstream of the canonical Rac GTPase CED-10, by polarizing the engulfing cell toward the apoptotic corpse in response to integrin signaling and ced-1/6/7 signaling in C. elegans.

Interplay between CedA, rpoB and double stranded DNA: A step towards understanding CedA mediated cell division in E. coli.

PubMed

Sharma, Pankaj; Tomar, Anil Kumar; Kundu, Bishwajit

2018-02-01

Cell division is compromised in DnaAcos mutant E. coli cells due to chromosome over-replication. In these cells, CedA acts as a regulatory protein and initiates cell division by a hitherto unknown mechanism. CedA, a double stranded DNA binding protein, interacts with various subunits of RNA polymerase complex, including rpoB. To reveal how this concert between CedA, rpoB and DNA brings about cell division in E. coli, we performed biophysical and in silico analysis and obtained mechanistic insights. Interaction between CedA and rpoB was shown by circular dichroism spectrometry and in silico docking experiments. Further, CedA and rpoB were allowed to interact individually to a selected DNA and their binding was monitored by fluorescence spectroscopy. The binding constants of these interactions as determined by BioLayer Interferometry clearly show that rpoB binds to DNA with higher affinity (K D2 =<1.0E-12M) as compared to CedA (K D2 =9.58E-09M). These findings were supported by docking analysis where 12 intermolecular H-bonds were formed in rpoB-DNA complex as compared to 4 in CedA-DNA complex. Based on our data we propose that in E. coli cells chromosome over-replication signals CedA to recruit rpoB to specific DNA site(s), which initiates transcription of cell division regulatory elements. Copyright © 2017 Elsevier B.V. All rights reserved.

Identification of functional interactome of a key cell division regulatory protein CedA of E.coli.

PubMed

Sharma, Pankaj; Tomar, Anil Kumar; Kundu, Bishwajit

2018-01-01

Cell division is compromised in DnaAcos mutant Escherichia coli cells that results in filamentous cell morphology. This is countered by over-expression of CedA protein that induces cytokinesis and thus, regular cell morphology is regained; however via an unknown mechanism. To understand the process systematically, exact role of CedA should be deciphered. Protein interactions are crucial for functional organization of a cell and their identification helps in revealing exact function(s) of a protein and its binding partners. Thus, this study was intended to identify CedA binding proteins (CBPs) to gain more clues of CedA function. We isolated CBPs by pull down assay using purified recombinant CedA and identified nine CBPs by mass spectrometric analysis (MALDI-TOF MS and LC-MS/MS), viz. PDHA1, RL2, DNAK, LPP, RPOB, G6PD, GLMS, RL3 and YBCJ. Based on CBPs identified, we hypothesize that CedA plays a crucial and multifaceted role in cell cycle regulation and specific pathways in which CedA participates may include transcription and energy metabolism. However, further validation through in-vitro and in-vivo experiments is necessary. In conclusion, identification of CBPs may help us in deciphering mechanism of CedA mediated cell division during chromosomal DNA over-replication. Copyright © 2017 Elsevier B.V. All rights reserved.

Energy and sports drinks in children and adolescents.

PubMed

Pound, Catherine M; Blair, Becky

2017-10-01

Sports drinks and caffeinated energy drinks (CEDs) are commonly consumed by youth. Both sports drinks and CEDs pose potential risks for the health of children and adolescents and may contribute to obesity. Sports drinks are generally unnecessary for children engaged in routine or play-based physical activity. CEDs may affect children and adolescents more than adults because they weigh less and thus experience greater exposure to stimulant ingredients per kilogram of body weight. Paediatricians need to recognize and educate patients and families on the differences between sport drinks and CEDs. Screening for the consumption of CEDs, especially when mixed with alcohol, should be done routinely. The combination of CEDs and alcohol may be a marker for higher risk of substance use or abuse and for other health-compromising behaviours.

IRAS surface brightness maps of reflection nebulae in the Pleiades

NASA Technical Reports Server (NTRS)

Castelaz, Michael W.; Werner, M. W.; Sellgren, K.

1987-01-01

Surface brightness maps at 12, 25, 60, and 100 microns were made of a 2.5 deg x 2.5 deg area of the reflection nebulae in the Pleiades by coadding IRAS scans of this region. Emission is seen surrounding 17 Tau, 20 Tau, 23 Tau, and 25 Tau in all four bands, coextensive with the visible reflection nebulosity, and extending as far as 30 arcminutes from the illuminating stars. The infrared energy distributions of the nebulae peak in the 100 micron band, but up to 40 percent of the total infrared power lies in the 12 and 25 micron bands. The brightness of the 12 and 25 micron emission and the absence of temperature gradients at these wavelengths are inconsistent with the predictions of equilibrium thermal emission models. The emission at these wavelengths appears to be the result of micron nonequilibrium emission from very small grains, or from molecules consisting of 10-100 carbon atoms, which have been excited by ultraviolet radiation from the illuminating stars.

Conducted energy devices: pilot analysis of (non-)attributability of death using a modified Naranjo algorithm.

PubMed

Fox, Anthony W; Payne-James, J Jason

2012-11-30

Alleged fatalities associated with conductive-energy devices (CEDs) are similar to alleged serious adverse events (SAEs) after the use of pharmaceutical products: both types of case arise rarely, in complex (if not unique) combinations of circumstances, frequently when there are multiple concomitant putative aetiologies for the injury, and after the suspected product has been previously well-designed and tested. Attribution (or otherwise) of SAEs to pharmaceutical products is often assessed by use of the Naranjo algorithm. The purpose of this study was to investigate whether an adapted Naranjo algorithm could be used to assess alleged CED-associated fatalities. Unique cases had four independent identifiers. Prospectively, 7 (of the 10) Naranjo algorithm questions were chosen as being potentially applicable to CED use. These had maximum score 9, and the associated ordinal probability scale (doubtful, possible, probable, and definite) was retained by linear proportion to the integral scores. An arbitrary requirement was for database sufficiency≥50%=([n unique cases×7 questions answerable]×0.5); a pilot sample (n=29 unique cases) suggested feasibility (see below). One hundred and seventy-five unique cases were found, with a data sufficiency of 56.8%. Modified Naranjo algorithm scores had an unequally bimodal distribution. CED-attributability was suggested in 21 (12% of 175) cases. Substantial numbers of concomitant conditions existed among cases with low algorithm scores, all being potentially lethal under field conditions without CED exposure. The number of CED-administered shocks sustained was unrelated to CED-attributability of fatality. Two of the Naranjo questions (regarding dechallenge and the effects of challenge with a non-identical but similar agent) proved to be non-contributory. An algorithmic approach to assessment of CED-associated fatality seems feasible. By these pharmacovigilance standards, some published case fatality rates attributable to CED exposure seem exaggerated. CED-attributable deaths have close similarity to Type-B SAEs. The latter are rare, unpredictable, and usually due to a patient idiosyncrasy. In the person being restrained, such idiosyncratic factors may be unavoidable by law enforcement officers (LEO) in the field. These are unlike predictable (Type-A) SAEs, which have their corollary amongst secondary CED-associated deaths, e.g., head injury among cyclists or ignition of an inflammable atmosphere by the CED, and are identifiable risk factors for which LEO can train. Regardless, absolute CED tolerability is obviously greater than that for firearms. A prospective registry of CED deployments would measure this more precisely. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Convection-Enhanced Delivery (CED) in an Animal Model of Malignant Peripheral Nerve Sheath Tumors and Plexiform Neurofibromas

DTIC Science & Technology

2011-09-01

with an accelerated schedule Convection-Enhanced Delivery ( CED ), Malignant Peripheral Nerve Sheath ( MPNST ), Plexiform Neurofibromas (PN...the distribution of macromolecules delivered to intraneural PNs and MPNST via CED . Design: Orthotopic xenograft models of sciatic intraneural NF1...determine the efficacy CED of the epidermal growth factor receptor (EGFR) inhibitor erlotinib in animal models of intraneural PNs and MPNST

Near-infrared Polarimetry of the Outflow Source AFGL 6366S: Detection of Circular Polarization

NASA Astrophysics Data System (ADS)

Kwon, Jungmi; Nakagawa, Takao; Tamura, Motohide; Hough, James H.; Kandori, Ryo; Choi, Minho; Kang, Miju; Cho, Jungyeon; Nakajima, Yasushi; Nagata, Tetsuya

2018-07-01

We have carried out near-infrared circular and linear imaging polarimetry of the AFGL 6366S region. There is one large infrared reflection nebula associated with the AFGL 6366S cluster and one small infrared reflection nebula associated with AFGL 6366S NE. Prominent and extended polarized nebulosities over the AFGL 6366S cluster field are found to be composed of several components and local nebula peaks, and those nebulosities are illuminated by at least three sources, which is roughly consistent with a previous study. However, the detailed linear polarization patterns and their degrees differ from the earlier study. The brightest regions of the nebulae are illuminated by the IRAS/WISE source. In addition, we report the first detection of circular polarization (CP) in the reflection nebula associated with AFGL 6366S. The CP is as large as approximately 4% in the K s band, and the maximum CP extent is approximately 0.45 pc, which is comparable to that for the largest CP regions known to date, such as Orion and Mon R2, although the CP degrees are much smaller. The CP pattern is mostly quadrupolar, and its morphology resembles the shape of the C18O dense core. Therefore, the CP region is probably illuminated by the IRAS/WISE source and its polarization is amplified by the dichroic absorption of the dense core associated with the cluster. This is the ninth source whose degrees of CPs are measured to be greater than 3%, suggesting that large and extended infrared CP regions are common among mid- to high-mass young stellar objects.

Concentration rather than dose defines the local brain toxicity of agents that are effectively distributed by convection-enhanced delivery.

PubMed

Zhang, Rong; Saito, Ryuta; Mano, Yui; Kanamori, Masayuki; Sonoda, Yukihiko; Kumabe, Toshihiro; Tominaga, Teiji

2014-01-30

Convection-enhanced delivery (CED) has been developed as a potentially effective drug-delivery strategy into the central nervous system. In contrast to systemic intravenous administration, local delivery achieves high concentration and prolonged retention in the local tissue, with increased chance of local toxicity, especially with toxic agents such as chemotherapeutic agents. Therefore, the factors that affect local toxicity should be extensively studied. With the assumption that concentration-oriented evaluation of toxicity is important for local CED, we evaluated the appearance of local toxicity among different agents after delivery with CED and studied if it is dose dependent or concentration dependent. Local toxicity profile of chemotherapeutic agents delivered via CED indicates BCNU was dose-dependent, whereas that of ACNU was concentration-dependent. On the other hand, local toxicity for doxorubicin, which is not distributed effectively by CED, was dose-dependent. Local toxicity for PLD, which is extensively distributed by CED, was concentration-dependent. Traditional evaluation of drug induced toxicity was dose-oriented. This is true for systemic intravascular delivery. However, with local CED, toxicity of several drugs exacerbated in concentration-dependent manner. From our study, local toxicity of drugs that are likely to distribute effectively tended to be concentration-dependent. Concentration rather than dose may be more important for the toxicity of agents that are effectively distributed by CED. Concentration-oriented evaluation of toxicity is more important for CED. Copyright © 2013 Elsevier B.V. All rights reserved.

Convection-Enhanced Delivery (CED) in an Animal Model of Malignant Peripheral Nerve Sheath (MPNST) Tumors and Plexiform Neurofibromas (PN)

DTIC Science & Technology

2012-09-01

TITLE: Convection-Enhanced Delivery ( CED ) in an Animal Model of Malignant Peripheral Nerve Sheath ( MPNST ) Tumors and Plexiform Neurofibromas (PN...within the sciatic nerve. 15. SUBJECT TERMS Convection-Enhanced Delivery ( CED ), Malignant Peripheral Nerve Sheath ( MPNST ), Plexiform Neurofibromas...determine the distribution of macromolecules delivered to intraneural PNs and MPNST via CED . Design: Orthotopic xenograft models of sciatic intraneural

Perceptions and Knowledge of Caffeinated Energy Drinks: Results of Focus Groups With Canadian Youth.

PubMed

McCrory, Cassondra; White, Christine M; Bowman, Carolyn; Fenton, Nancy; Reid, Jessica L; Hammond, David

2017-04-01

To examine use, knowledge, and perceptions of caffeinated energy drinks (CEDs) among youth. Qualitative research using focus group discussions (n = 4). Two Canadian cities (Toronto and Montreal). Youth aged 12-18 years (n = 41). Perceived definitions of CEDs, reasons for use, knowledge of health effects, use with alcohol, marketing perceptions, and use and understanding of cautionary statements on packaging. Data were analyzed using a modified grounded-theory approach. Youth identified CEDs as products that provide energy and contain caffeine and sugar. Compared with mainstream CED brands and energy shots, youth were less likely to perceive Gatorade, Coca-Cola, and a Starbucks beverage as energy drinks, despite some ambiguity. The majority of participants believed that CEDs, including mixed with alcohol, were not necessarily harmful in moderation and that marketing was targeted toward older youth and young adults. Awareness of cautionary statements on CEDs was low; cautionary statements were perceived as difficult to find and read owing to the design and small font. Findings suggest a need to increase public education regarding the potential risks of CED consumption, including enhancements to the mandated cautionary statements, with greater attention to the impact of CED marketing on youth. Copyright © 2016 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

A study of H-alpha velocities in NGC 1499, NGC 7000, and IC 1318B/C

NASA Technical Reports Server (NTRS)

Fountain, W. F.; Gary, G. A.; Odell, C. R.

1983-01-01

Multiple slit echelle spectrograph observations of the H-alpha emission line are used to map the radial velocities of the California Nebula (NGC 1499), the North American Nebula complex (NGC 7000 and IC 5070), and IC 1318B/C. The California Nebula is singularly constant in velocity, considering its geometry. The North American Nebula complex reflects a very simple, classical dynamical picture. The expansion discovered earlier in IC 1318B/C is confirmed, detailed, and the model refined. The new data, along with that in earlier papers of this series, show that stellar wind acceleration and champagne flow mechanisms both play important roles in determining the evolution of H II regions.

Photometry and Classification of Stars around the Reflection Nebula NGC 7023 IN Cepheus. I. A Catalog of Magnitudes, Color Indices and Spectral Types of 1240 Stars

NASA Astrophysics Data System (ADS)

Zdanavičius, K.; Zdanavičius, J.; Straižys, V.; Kotovas, A.

The catalog contains magnitudes and color indices of 1240 stars down to ˜ 16.7 mag in V measured in the seven-color Vilnius photometric system in the area of 1.5 square degrees around the reflection nebula NGC 7023 in Cepheus. For most of the stars spectral types determined from the photometric data are given. A large number of visual binaries with separations between 3'' and 10'' are identified using the DSS2 images.

Convection-Enhanced Delivery (CED) in an Animal Model of Malignant Peripheral Nerve Sheath Tumors and Plexiform Neurofibromas

DTIC Science & Technology

2013-02-01

successfully establish the xenograft within the sciatic nerve. Convection-Enhanced Delivery ( CED ), Malignant Peripheral Nerve Sheath ( MPNST ), Plexiform...intraneural PNs and MPNST via CED . Design: Orthotopic xenograft models of sciatic intraneural NF1 MPNST and PNs in scid mice as described by Perrin et...using convection-enhanced delivery ( CED ). Relative Growth of MPNST cells in vivo treated with rapamycin, imatinib or erlotinib: Elotinib

Convection enhanced delivery of carmustine to the murine brainstem: a feasibility study.

PubMed

Sewing, A Charlotte P; Caretti, Viola; Lagerweij, Tonny; Schellen, Pepijn; Jansen, Marc H A; van Vuurden, Dannis G; Idema, Sander; Molthoff, Carla F M; Vandertop, W Peter; Kaspers, Gertjan J L; Noske, David P; Hulleman, Esther

2014-12-30

Systemic delivery of therapeutic agents remains ineffective against diffuse intrinsic pontine glioma (DIPG), possibly due to an intact blood-brain-barrier (BBB) and to dose-limiting toxicity of systemic chemotherapeutic agents. Convection-enhanced delivery (CED) into the brainstem may provide an effective local delivery alternative for DIPG patients. The aim of this study is to develop a method to perform CED into the murine brainstem and to test this method using the chemotherapeutic agent carmustine (BiCNU). To this end, a newly designed murine CED catheter was tested in vitro and in vivo. After determination of safety and distribution, mice bearing VUMC-DIPG-3 and E98FM-DIPG brainstem tumors were treated with carmustine dissolved in DW 5% or carmustine dissolved in 10% ethanol. Our results show that CED into the murine brainstem is feasible and well tolerated by mice with and without brainstem tumors. CED of carmustine dissolved in 5% DW increased median survival of mice with VUMC-DIPG-3 and E98FM-DIPG tumors with 35% and 25% respectively. Dissolving carmustine in 10% ethanol further improved survival to 45% in mice with E98FM-DIPG tumors. Since genetically engineered and primary DIPG models are currently only available in mice, murine CED studies have clear advantages over CED studies in other animals. CED in the murine brainstem can be performed safely, is well tolerated and can be used to study efficacy of chemotherapeutic agents orthotopically. These results set the foundation for more CED studies in murine DIPG models. Copyright © 2014 Elsevier B.V. All rights reserved.

Exploration of resistive targets within shallow marine environments using the circular electrical dipole and the differential electrical dipole methods: a time-domain modelling study

NASA Astrophysics Data System (ADS)

Haroon, Amir; Mogilatov, Vladimir; Goldman, Mark; Bergers, Rainer; Tezkan, Bülent

2016-05-01

Two novel transient controlled source electromagnetic methods called circular electrical dipole (CED) and differential electrical dipole (DED) are theoretically analysed for applications in shallow marine environments. 1-D and 3-D time-domain modelling studies are used to investigate the detectability and applicability of the methods when investigating resistive layers/targets representing hydrocarbon-saturated formations. The results are compared to the conventional time-domain horizontal electrical dipole (HED) and vertical electrical dipole (VED) sources. The applied theoretical modelling studies demonstrate that CED and DED have higher signal detectability towards resistive targets compared to TD-CSEM, but demonstrate significantly poorer signal amplitudes. Future CED/DED applications will have to solve this issue prior to measuring. Furthermore, the two novel methods have very similar detectability characteristics towards 3-D resistive targets embedded in marine sediments as VED while being less susceptible towards non-verticality. Due to the complex transmitter design of CED/DED the systems are prone to geometrical errors. Modelling studies show that even small transmitter inaccuracies have strong effects on the signal characteristics of CED making an actual marine application difficult at the present time. In contrast, the DED signal is less affected by geometrical errors in comparison to CED and may therefore be more adequate for marine applications.

Coverage with Evidence Development: applications and issues.

PubMed

Trueman, Paul; Grainger, David L; Downs, Kristen E

2010-01-01

The aim of this study was to describe the current issues surrounding Coverage with Evidence Development (CED). CED is characterized by restricted coverage for a new technology in parallel with targeted research when the stated goal of the research or data collection is to provide definitive evidence for the clinical or cost-effectiveness impact of the new technology. Presented here is information summarized and interpreted from presentations and discussions at the 2008 Health Technology Assessment International (HTAi) meeting and additional information from the medical literature. This study describes the differences between CED and other conditional coverage agreements, provides a brief history of CED, describes real-world examples of CED, describes the areas of consensus between the stakeholders, discusses the areas for future negotiation between stakeholders, and proposes criteria to assist stakeholders in determining when CED could be appropriate. Payers could interpret the evidence obtained from a CED program either positively or negatively, and a range of possible changes to the reimbursement status of the new technology may result. Striking an appropriate balance between the demands for prompt access to new technology and acknowledging that some degree of uncertainty will always exist is a critical challenge to the uptake of this innovative form of conditional coverage. When used selectively for innovative procedures, pharmaceuticals, or devices in the appropriate disease areas, CED may provide patients access to promising medicines or technologies while data to minimize uncertainty are collected.

Functional analysis of CedA based on its structure: residues important in binding of DNA and RNA polymerase and in the cell division regulation

PubMed Central

Abe, Yoshito; Fujisaki, Naoki; Miyoshi, Takanori; Watanabe, Noriko; Katayama, Tsutomu; Ueda, Tadashi

2016-01-01

DnaAcos, a mutant of the initiator DnaA, causes overinitiation of chromosome replication in Escherichia coli, resulting in inhibition of cell division. CedA was found to be a multi-copy suppressor which represses the dnaAcos inhibition of cell division. However, functional mechanism of CedA remains elusive except for previously indicated possibilities in binding to DNA and RNA polymerase. In this study, we searched for the specific sites of CedA in binding of DNA and RNA polymerase and in repression of cell division inhibition. First, DNA sequence to which CedA preferentially binds was determined. Next, the several residues and β4 region in CedA C-terminal domain was suggested to specifically interact with the DNA. Moreover, we found that the flexible N-terminal region was required for tight binding to longer DNA as well as interaction with RNA polymerase. Based on these results, several cedA mutants were examined in ability for repressing dnaAcos cell division inhibition. We found that the N-terminal region was dispensable and that Glu32 in the C-terminal domain was required for the repression. These results suggest that CedA has multiple roles and residues with different functions are positioned in the two regions. PMID:26400504

The Use of Surrogate and Patient-Relevant Endpoints in Outcomes-Based Market Access Agreements : Current Debate.

PubMed

Toumi, Mondher; Jarosławski, Szymon; Sawada, Toyohiro; Kornfeld, Åsa

2017-02-01

The high cost of novel treatments is the major driver of negative or restricted reimbursement decisions by healthcare payers in many countries. Costly drugs can be subject to Market Access Agreements (MAAs), which are financial (Commercial Agreements [CAs]) or outcomes-based (Payment for Performance Agreements [P4Ps] or Coverage with Evidence Development agreements [CEDs]). Outcomes in outcomes-based MAAs are assessed through changes in surrogate endpoints (SEPs) or patient-relevant endpoints (PEPs). In May 2015, we reviewed published and grey literature on MAAs between manufacturers and large, institutionalised payers from all geographical areas, and classified the schemes into CAs, P4Ps and CEDs, as well as by therapeutic area and country. Outcomes-based MAAs were further categorized by the endpoint used. Overall, we identified 143 MAAs, 56 (39.2 %) of which were pure CAs, 53 (37.1 %) were CEDs, and 34 (23.8 %) were P4Ps. Among the CEDs, 49 were PEP CEDs and four were SEP CEDs; of the 34 P4Ps, 29 were SEP P4Ps for 30 drugs, and five were PEP P4Ps for at least six drugs; and among 87 outcomes-based MAAs (CEDs + P4Ps), PEP CEDs were the most common (56.3 %), followed by SEP P4Ps (34.1 %). The high proportion of SEPs used in P4Ps contrasts with the high proportion of PEPs used in CEDs. CEDs employ PEPs and it appears that they are used to reduce uncertainty about a drug's clinical outcomes and/or real-life use, and thus allow payers to align a product's value with price. We argue that P4Ps do not reduce uncertainty about real-life effectiveness and can only constitute an outcome guarantee for payers if they are based on PEPs or validated SEPs.

The distribution and mortality impact of chronic energy deficiency among adult Nigerian men and women.

PubMed

Rotimi, C; Okosun, I; Johnson, L; Owoaje, E; Lawoyin, T; Asuzu, M; Kaufman, J; Adeyemo, A; Cooper, R

1999-09-01

To determine the prevalence of chronic energy deficiency (CED) and associated mortality risk in a cohort of adult Nigerians followed from 1992 to 1997. The data for this investigation were derived from an international collaborative study on chronic diseases in populations of the African diaspora. Body mass index (BMI) was used to define three grades of CED in 4061 men and women aged 25 years and older: Grade I (mild CED) as BMI 17.5-18.4, Grade II (moderate CED) as BMI 16.0-17.4, and Grade III (severe CED) as BMI < 16.0 and BMI > or = 18.5 was considered normal. The odds of mortality associated with differing grades of CED was estimated with logistic regression analysis. The prevalence of CED (BMI < 18.5) increased from 14.3% in 1992 to 19.6% in 1997, both genders combined. The prevalence of CED was similar for both sexes in 1992 (14%) but increased to 22.4% in men and 17.4% in women by 1997. The prevalence of CED was 8.5%, 7.6 and 3.4 for Grades I, II and III, respectively. Two hundred and seven deaths occurred during the follow-up period. The mortality rate for the 5.5 y of follow-up was 5.1% (207/4061). The odds ratios (95% CIs) for all cause mortality were 1.4 (0.5, 3.8), 2.4 (1.2, 4.9) and 2.5 (1.0, 6.2), respectively, for CED grades I, II and III adjusting for age and sex. Under nutrition is an increasing problem in Nigerian men and women. The economic reforms (structural adjustment program (SAP)) introduced in 1986 in combination with the continued economic woes brought on by political instability, corruption and nepotism have been advanced by several investigators as the main factors in the growing problem of inadequate calorie intake. Intervention strategies both at the government and private sectors are urgently needed to increase food availability.

Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models.

PubMed

Ogita, Shogo; Endo, Toshiki; Sugiyama, Shinichiro; Saito, Ryuta; Inoue, Tomoo; Sumiyoshi, Akira; Nonaka, Hiroi; Kawashima, Ryuta; Sonoda, Yukihiko; Tominaga, Teiji

2017-05-01

Convection-enhanced delivery (CED) is a technique allowing local infusion of therapeutic agents into the central nervous system, circumventing the blood-brain or spinal cord barrier. To evaluate the utility of nimustine hydrochloride (ACNU) CED in controlling tumor progression in an experimental spinal cord glioma model. Toxicity studies were performed in 42 rats following the administration of 4 μl of ACNU CED into the mid-thoracic spinal cord at concentrations ranging from 0.1 to 10 mg/ml. Behavioral analyses and histological evaluations were performed to assess ACNU toxicity in the spinal cord. A survival study was performed in 32 rats following the implantation of 9 L cells into the T8 spinal cord. Seven days after the implantation, rats were assigned to four groups: ACNU CED (0.25 mg/ml; n = 8); ACNU intravenous (i.v.) (0.4 mg; n = 8); saline CED (n = 8); saline i.v. (n = 8). Hind limb movements were evaluated daily in all rats for 21 days. Tumor sizes were measured histologically. The maximum tolerated ACNU concentration was 0.25 mg/ml. Preservation of hind limb motor function and tumor growth suppression was observed in the ACNU CED (0.25 mg/ml) and ACNU i.v. groups. Antitumor effects were more prominent in the ACNU CED group especially in behavioral analyses (P < 0.05; log-rank test). ACNU CED had efficacy in controlling tumor growth and preserving neurological function in an experimental spinal cord tumor model. ACNU CED can be a viable treatment option for spinal cord high-grade glioma.

Convection-enhanced delivery of SN-38-loaded polymeric micelles (NK012) enables consistent distribution of SN-38 and is effective against rodent intracranial brain tumor models.

PubMed

Zhang, Rong; Saito, Ryuta; Mano, Yui; Sumiyoshi, Akira; Kanamori, Masayuki; Sonoda, Yukihiko; Kawashima, Ryuta; Tominaga, Teiji

2016-10-01

Convection-enhanced delivery (CED) of therapeutic agents is a promising local delivery technique that has been extensively studied as a treatment for CNS diseases over the last two decades. One continuing challenge of CED is accurate and consistent delivery of the agents to the target. The present study focused on a new type of therapeutic agent, NK012, a novel SN-38-loaded polymeric micelle. Local delivery profiles of NK012 and SN-38 were studied using rodent brain and intracranial rodent brain tumor models. First, the cytotoxicity of NK012 against glioma cell lines was determined in vitro. Proliferations of glioma cells were significantly reduced after exposure to NK012. Then, the distribution and local toxicity after CED delivery of NK012 and SN-38 were evaluated in vivo. Volume of distribution of NK012 after CED was much larger than that of SN-38. Histological examination revealed minimum brain tissue damage in rat brains after delivery of 40 µg NK012 but severe damage with SN-38 at the same dose. Subsequently, the efficacy of NK012 delivered via CED was tested in 9L and U87MG rodent orthotopic brain tumor models. CED of NK012 displayed excellent efficacy in the 9L and U87MG orthotopic brain tumor models. Furthermore, NK012 and gadolinium diamide were co-delivered via CED to monitor the NK012 distribution using MRI. Volume of NK012 distribution evaluated by histology and MRI showed excellent agreement. CED of NK012 represents an effective treatment option for malignant gliomas. MRI-guided CED of NK012 has potential for clinical application.

An integrated evaluation for the performance of clinical engineering department.

PubMed

Yousry, Ahmed M; Ouda, Bassem K; Eldeib, Ayman M

2014-01-01

Performance benchmarking have become a very important component in all successful organizations nowadays that must be used by Clinical Engineering Department (CED) in hospitals. Many researchers identified essential mainstream performance indicators needed to improve the CED's performance. These studies revealed mainstream performance indicators that use the database of a CED to evaluate its performance. In this work, we believe that those indicators are insufficient for hospitals. Additional important indicators should be included to improve the evaluation accuracy. Therefore, we added new indicators: technical/maintenance indicators, economic indicators, intrinsic criticality indicators, basic hospital indicators, equipment acquisition, and safety indicators. Data is collected from 10 hospitals that cover different types of healthcare organizations. We developed a software tool that analyses collected data to provide a score for each CED under evaluation. Our results indicate that there is an average gap of 67% between the CEDs' performance and the ideal target. The reasons for the noncompliance are discussed in order to improve performance of CEDs under evaluation.

The Conservation Efforts Database: Improving our knowledge of landscape conservation actions

USGS Publications Warehouse

Heller, Matthew M.; Welty, Justin; Wiechman , Lief A.

2017-01-01

The Conservation Efforts Database (CED) is a secure, cloud-based tool that can be used to document and track conservation actions across landscapes. A recently released factsheet describes this tool ahead of the rollout of CED version 2.0. The CED was developed by the U.S. Fish and Wildlife Service, the USGS, and the Great Northern Landscape Conservation Cooperative to support the 2015 Endangered Species Act status review for greater sage-grouse. Currently, the CED accepts policy-level data, such as Land Use Plans, and treatment level data, such as conifer removals and post-fire recovery efforts, as custom spatial and non-spatial records. In addition to a species assessment tool, the CED can also be used to summarize the extent of restoration efforts within a specific area or to strategically site conservation actions based on the location of other implemented actions. The CED can be an important tool, along with post-conservation monitoring, for implementing landscape-scale adaptive management.

Functional analysis of CedA based on its structure: residues important in binding of DNA and RNA polymerase and in the cell division regulation.

PubMed

Abe, Yoshito; Fujisaki, Naoki; Miyoshi, Takanori; Watanabe, Noriko; Katayama, Tsutomu; Ueda, Tadashi

2016-02-01

DnaAcos, a mutant of the initiator DnaA, causes overinitiation of chromosome replication in Escherichia coli, resulting in inhibition of cell division. CedA was found to be a multi-copy suppressor which represses the dnaAcos inhibition of cell division. However, functional mechanism of CedA remains elusive except for previously indicated possibilities in binding to DNA and RNA polymerase. In this study, we searched for the specific sites of CedA in binding of DNA and RNA polymerase and in repression of cell division inhibition. First, DNA sequence to which CedA preferentially binds was determined. Next, the several residues and β4 region in CedA C-terminal domain was suggested to specifically interact with the DNA. Moreover, we found that the flexible N-terminal region was required for tight binding to longer DNA as well as interaction with RNA polymerase. Based on these results, several cedA mutants were examined in ability for repressing dnaAcos cell division inhibition. We found that the N-terminal region was dispensable and that Glu32 in the C-terminal domain was required for the repression. These results suggest that CedA has multiple roles and residues with different functions are positioned in the two regions. © The Authors 2015. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment.

PubMed

Zhou, Zhiping; Singh, Ranjodh; Souweidane, Mark M

2017-01-01

Convection-enhanced delivery (CED) is a technique designed to deliver drugs directly into the brain or tumors. Its ability to bypass the blood-brain barrier (BBB), one of the major hurdles in delivering drugs to the brain, has made it a promising drug delivery method for the treatment of primary brain tumors. A number of clinical trials utilizing CED of various therapeutic agents have been conducted to treat patients with supratentorial high-grade gliomas. Significant responses have been observed in certain patients in all of these trials. However, the insufficient ability to monitor drug distribution and pharmacokinetics hampers CED from achieving its potentials on a larger scale. Brainstem CED for diffuse intrinsic pontine glioma (DIPG) treatment is appealing because this tumor is compact and has no definitive treatment. The safety of brainstem CED has been established in small and large animals, and recently in early stage clinical trials. There are a few current clinical trials of brainstem CED in treating DIPG patients using targeted macromolecules such as antibodies and immunotoxins. Future advances for CED in DIPG treatment will come from several directions including: choosing the right agents for infusion; developing better agents and regimen for DIPG infusion; improving instruments and technique for easier and accurate surgical targeting and for allowing multisession or prolonged infusion to implement optimal time sequence; and better understanding and control of drug distribution, clearance and time sequence. CED-based therapies for DIPG will continue to evolve with new understanding of the technique and the disease.

Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment

PubMed Central

Zhou, Zhiping; Singh, Ranjodh; Souweidane, Mark M.

2017-01-01

Convection-enhanced delivery (CED) is a technique designed to deliver drugs directly into the brain or tumors. Its ability to bypass the blood-brain barrier (BBB), one of the major hurdles in delivering drugs to the brain, has made it a promising drug delivery method for the treatment of primary brain tumors. A number of clinical trials utilizing CED of various therapeutic agents have been conducted to treat patients with supratentorial high-grade gliomas. Significant responses have been observed in certain patients in all of these trials. However, the insufficient ability to monitor drug distribution and pharmacokinetics hampers CED from achieving its potentials on a larger scale. Brainstem CED for diffuse intrinsic pontine glioma (DIPG) treatment is appealing because this tumor is compact and has no definitive treatment. The safety of brainstem CED has been established in small and large animals, and recently in early stage clinical trials. There are a few current clinical trials of brainstem CED in treating DIPG patients using targeted macromolecules such as antibodies and immunotoxins. Future advances for CED in DIPG treatment will come from several directions including: choosing the right agents for infusion; developing better agents and regimen for DIPG infusion; improving instruments and technique for easier and accurate surgical targeting and for allowing multisession or prolonged infusion to implement optimal time sequence; and better understanding and control of drug distribution, clearance and time sequence. CED-based therapies for DIPG will continue to evolve with new understanding of the technique and the disease. PMID:27306036

13 CFR 303.6 - EDA-funded CEDS process.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PLANNING INVESTMENTS AND COMPREHENSIVE ECONOMIC DEVELOPMENT STRATEGIES § 303.6 EDA-funded CEDS process. If EDA awards Investment Assistance to a Planning Organization to develop, revise or replace a CEDS, the... must appoint a Strategy Committee. The Strategy Committee must represent the main economic interests of...

Multi-wavelength observations of the peculiar red giant HR 3126

NASA Technical Reports Server (NTRS)

Pesce, Joseph E.; Stencel, Robert E.; Walter, Frederick M.; Doggett, Jesse; Dachs, Joachim; Whitelock, Patricia A.; Mundt, Reinhard

1988-01-01

Ultraviolet observations of the red giant HR 3126 are combined with multi-wavelength data in order to provide a firmer basis for explaining the arc-minute sized nebula surrounding the object. Possibilities as to the location of HR 3126 on the Hertzsprung-Russel diagram, and to the formation mechanisms of the reflection nebula IC 2220 associated with it, are summarized.

Hubble Space Telescope Imaging of the Mass-losing Supergiant VY Canis Majoris

NASA Astrophysics Data System (ADS)

Kastner, Joel H.; Weintraub, David A.

1998-04-01

The highly luminous M supergiant VY CMa is a massive star that appears to be in its final death throes, losing mass at high rate en route to exploding as a supernova. Subarcsecond-resolution optical images of VY CMa, obtained with the Faint Object Camera (FOC) aboard the Hubble Space Telescope, vividly demonstrate that mass loss from VY CMa is highly anisotropic. In the FOC images, the optical ``star'' VY CMa constitutes the bright, well-resolved core of an elongated reflection nebula. The imaged nebula is ~3" (~4500 AU) in extent and is clumpy and highly asymmetric. The images indicate that the bright core, which lies near one edge of the nebula, is pure scattered starlight. We conclude that at optical wavelengths VY CMa is obscured from view along our line of sight by its own dusty envelope. The presence of the extended reflection nebula then suggests that this envelope is highly flattened and/or that the star is surrounded by a massive circumstellar disk. Such axisymmetric circumstellar density structure should have profound effects on post-red supergiant mass loss from VY CMa and, ultimately, on the shaping of the remnant of the supernova that will terminate its post-main-sequence evolution.

THE INFRARED SPECTRUM OF PROTONATED OVALENE IN SOLID PARA-HYDROGEN AND ITS POSSIBLE CONTRIBUTION TO INTERSTELLAR UNIDENTIFIED INFRARED EMISSION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsuge, Masashi; Bahou, Mohammed; Lee, Yuan-Pern

The mid-infrared emission from galactic objects, including reflection nebulae, planetary nebulae, proto-planetary nebulae, molecular clouds, etc, as well as external galaxies, is dominated by the unidentified infrared (UIR) emission bands. Large protonated polycyclic aromatic hydrocarbons (H{sup +}PAHs) were proposed as possible carriers, but no spectrum of an H{sup +}PAH has been shown to exactly match the UIR bands. Here, we report the IR spectrum of protonated ovalene (7-C{sub 32}H{sub 15} {sup +}) measured in a para -hydrogen ( p -H{sub 2}) matrix at 3.2 K, generated by bombarding a mixture of ovalene and p -H{sub 2} with electrons during matrixmore » deposition. Spectral assignments were made based on the expected chemistry and on the spectra simulated with the wavenumbers and infrared intensities predicted with the B3PW91/6-311++G(2d,2p) method. The close resemblance of the observed spectral pattern to that of the UIR bands suggests that protonated ovalene may contribute to the UIR emission, particularly from objects that emit Class A spectra, such as the IRIS reflection nebula, NGC 7023.« less

Reflected Glory

NASA Astrophysics Data System (ADS)

2011-02-01

The nebula Messier 78 takes centre stage in this image taken with the Wide Field Imager on the MPG/ESO 2.2-metre telescope at the La Silla Observatory in Chile, while the stars powering the bright display take a backseat. The brilliant starlight ricochets off dust particles in the nebula, illuminating it with scattered blue light. Igor Chekalin was the overall winner of ESO's Hidden Treasures 2010 astrophotography competition with his image of this stunning object. Messier 78 is a fine example of a reflection nebula. The ultraviolet radiation from the stars that illuminate it is not intense enough to ionise the gas to make it glow - its dust particles simply reflect the starlight that falls on them. Despite this, Messier 78 can easily be observed with a small telescope, being one of the brightest reflection nebulae in the sky. It lies about 1350 light-years away in the constellation of Orion (The Hunter) and can be found northeast of the easternmost star of Orion's belt. This new image of Messier 78 from the MPG/ESO 2.2-metre telescope at the La Silla Observatory is based on data selected by Igor Chekalin in his winning entry to the Hidden Treasures competition [1]. The pale blue tint seen in the nebula in this picture is an accurate representation of its dominant colour. Blue hues are commonly seen in reflection nebulae because of the way the starlight is scattered by the tiny dust particles that they contain: the shorter wavelength of blue light is scattered more efficiently than the longer wavelength red light. This image contains many other striking features apart from the glowing nebula. A thick band of obscuring dust stretches across the image from the upper left to the lower right, blocking the light from background stars. In the bottom right corner, many curious pink structures are also visible, which are created by jets of material being ejected from stars that have recently formed and are still buried deep in dust clouds. Two bright stars, HD 38563A and HD 38563B, are the main powerhouses behind Messier 78. However, the nebula is home to many more stars, including a collection of about 45 low mass, young stars (less than 10 million years old) in which the cores are still too cool for hydrogen fusion to start, known as T Tauri stars. Studying T Tauri stars is important for understanding the early stages of star formation and how planetary systems are created. Remarkably, this complex of nebulae has also changed significantly in the last ten years. In February 2004 the experienced amateur observer Jay McNeil took an image of this region with a 75 mm telescope and was surprised to see a bright nebula - the prominent fan shaped feature near the bottom of this picture - where nothing was seen on most earlier images. This object is now known as McNeil's Nebula and it appears to be a highly variable reflection nebula around a young star. This colour picture was created from many monochrome exposures taken through blue, yellow/green and red filters, supplemented by exposures through an H-alpha filter that shows light from glowing hydrogen gas. The total exposure times were 9, 9, 17.5 and 15.5 minutes per filter, respectively. Notes [1] Igor Chekalin from Russia uncovered the raw data for this image of Messier 78 in ESO's archives in the competition Hidden Treasures (eso1102). He processed the raw data with great skill, claiming first prize in the contest for his final image (Flickr link). ESO's team of in-house image processing experts then independently processed the raw data at full resolution to produce the image shown here. More information ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 15 countries: Austria, Belgium, Brazil, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

Instructional Design Issues in a Distributed Collaborative Engineering Design (CED) Instructional Environment

ERIC Educational Resources Information Center

Koszalka, Tiffany A.; Wu, Yiyan

2010-01-01

Changes in engineering practices have spawned changes in engineering education and prompted the use of distributed learning environments. A distributed collaborative engineering design (CED) course was designed to engage engineering students in learning about and solving engineering design problems. The CED incorporated an advanced interactive…

12 CFR 28.15 - Capital equivalency deposits.

Code of Federal Regulations, 2011 CFR

2011-01-01

... provided by the OCC, a foreign bank's capital equivalency deposits (CED) must consist of: (i) Investment... increase its CED above the minimum amount. For example, the OCC may require an increase if a Federal branch... arrangements. A foreign bank should require its depository bank to segregate its CED on the depository bank's...

12 CFR 28.15 - Capital equivalency deposits.

Code of Federal Regulations, 2012 CFR

2012-01-01

... provided by the OCC, a foreign bank's capital equivalency deposits (CED) must consist of: (i) Investment... increase its CED above the minimum amount. For example, the OCC may require an increase if a Federal branch... arrangements. A foreign bank should require its depository bank to segregate its CED on the depository bank's...

12 CFR 28.15 - Capital equivalency deposits.

Code of Federal Regulations, 2014 CFR

2014-01-01

... provided by the OCC, a foreign bank's capital equivalency deposits (CED) must consist of: (i) Investment... or agency in a state, it shall determine the CED and the amount of liabilities requiring capital... cases or otherwise, that a foreign bank increase its CED above the minimum amount. For example, the OCC...

12 CFR 28.15 - Capital equivalency deposits.

Code of Federal Regulations, 2013 CFR

2013-01-01

... provided by the OCC, a foreign bank's capital equivalency deposits (CED) must consist of: (i) Investment... or agency in a state, it shall determine the CED and the amount of liabilities requiring capital... cases or otherwise, that a foreign bank increase its CED above the minimum amount. For example, the OCC...

12 CFR 28.15 - Capital equivalency deposits.

Code of Federal Regulations, 2010 CFR

2010-01-01

... provided by the OCC, a foreign bank's capital equivalency deposits (CED) must consist of: (i) Investment... increase its CED above the minimum amount. For example, the OCC may require an increase if a Federal branch... arrangements. A foreign bank should require its depository bank to segregate its CED on the depository bank's...

CEDS Addresses: Virtual and Blended Learning

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

The Common Education Data Standards (CEDS) common data vocabulary supports the collection and use of information about virtual and blended learning. The data element "Virtual Indicator", introduced in version 3 of CEDS, supports a range of virtual learning-related use cases. The Virtual Indicator element may be related to a Course…

Convection-enhanced delivery of maghemite nanoparticles: Increased efficacy and MRI monitoring

PubMed Central

Perlstein, Benny; Ram, Zvi; Daniels, Dianne; Ocherashvilli, Aharon; Roth, Yiftach; Margel, Shlomo; Mardor, Yael

2008-01-01

Convection-enhanced drug delivery (CED) is a novel approach to delivering drugs into brain tissue. Drugs are delivered continuously via a catheter, enabling large volume distributions of high drug concentrations with minimum systemic toxicity. Previously we demonstrated that CED formation/extent of small molecules may be significantly improved by increasing infusate viscosities. In this study we show that the same methodology can be applied to monodispersed maghemite nanoparticles (MNPs). For this purpose we used a normal rat brain model and performed CED of MNPs over short infusion times. By adding 3% sucrose or 3%–6% polyethylene glycol (PEG; molecular weight 400) to saline containing pristine MNPs, we increased infusate viscosity and obtained increased CED efficacy. Further, we show that CED of dextran-coated MNPs (dextran-MNPs) resulted in increased efficacy over pristine MNPs (p < 0.007). To establish the use of MRI for reliable depiction of MNP distribution, CED of fluorescent dextran-MNPs was performed, demonstrating a significant correlation between the distributions as depicted by MRI and spectroscopic images (r2 = 0.74, p < 0.0002). MRI follow-up showed that approximately 80%–90% of the dextran-MNPs were cleared from the rat brain within 40 days of CED; the rest remained in the brain for more than 4 months. MNPs have been tested for applications such as targeted drug delivery and controlled drug release and are clinically used as a contrast agent for MRI. Thus, combining the CED method with the advantages of MNPs may provide a powerful tool to treat and monitor brain tumors. PMID:18316474

7 CFR 1221.232 - Disposition of records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... summaries. Such records will be placed in a secure location under the custody of FSA CED for a period of not... FSA CED will place in sealed containers marked with the identification of the “Sorghum Checkoff... the Administrator, FSA, by the end of the 12 month period as described above, the CED or designee...

7 CFR 1221.232 - Disposition of records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... summaries. Such records will be placed in a secure location under the custody of FSA CED for a period of not... FSA CED will place in sealed containers marked with the identification of the “Sorghum Checkoff... the Administrator, FSA, by the end of the 12 month period as described above, the CED or designee...

7 CFR 1221.232 - Disposition of records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... summaries. Such records will be placed in a secure location under the custody of FSA CED for a period of not... FSA CED will place in sealed containers marked with the identification of the “Sorghum Checkoff... the Administrator, FSA, by the end of the 12 month period as described above, the CED or designee...

7 CFR 1221.232 - Disposition of records.

Code of Federal Regulations, 2014 CFR

2014-01-01

... summaries. Such records will be placed in a secure location under the custody of FSA CED for a period of not... FSA CED will place in sealed containers marked with the identification of the “Sorghum Checkoff... the Administrator, FSA, by the end of the 12 month period as described above, the CED or designee...

Application of corona electrical discharge plasma on modifying the physicochemical properties of banana starch indigenous to Taiwan.

PubMed

Wu, Tsung-Yen; Sun, Nan-Nong; Chau, Chi-Fai

2018-01-01

Corona electrical discharge (CED) belongs to an atmospheric pressure cold plasma. In this study, raw banana starch (indigenous to Taiwan), which contained resistant starch and amylose at a level of 58.4 g/100 g and 14.5 g/100 g, respectively, was treated by CED at 30 kV/cm, 40 kV/cm, and 50 kV/cm for 3 minutes. After the CED treatment, starch analyses showed that there were no apparent changes in the resistant starch and amylose contents. Only surface and nonpenetrative damage caused by plasma etching at different voltage strengths were observed on the starch granules. The CED treatments reduced the total area of diffraction peak, gelatinization enthalpy (by -21% to -38%), and different pasting behaviors including peak viscosity, breakdown, final viscosity, and setback. The CED treatments were capable of increasing relative crystallinity and gelatinization temperature. This study revealed the potential of CED plasma technology as a tool to modify the characteristics of banana starch. Copyright © 2017. Published by Elsevier B.V.

Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations.

PubMed

Barua, Neil U; Gill, Steven S; Love, Seth

2014-03-01

Convection-enhanced delivery (CED) describes a direct method of drug delivery to the brain through intraparenchymal microcatheters. By establishing a pressure gradient at the tip of the infusion catheter in order to exploit bulk flow through the interstitial spaces of the brain, CED offers a number of advantages over conventional drug delivery methods-bypass of the blood-brain barrier, targeted distribution through large brain volumes and minimization of systemic side effects. Despite showing early promise, CED is yet to fulfill its potential as a mainstream strategy for the treatment of neurological disease. Substantial research effort has been dedicated to optimize the technology for CED and identify the parameters, which govern successful drug distribution. It seems likely that successful clinical translation of CED will depend on suitable catheter technology being used in combination with drugs with optimal physicochemical characteristics, and on neuropathological analysis in appropriate preclinical models. In this review, we consider the factors most likely to influence the success or failure of CED, and review its application to the treatment of high-grade glioma, Parkinson's disease (PD) and Alzheimer's disease (AD). © 2013 International Society of Neuropathology.

Programmed Cell Death During Caenorhabditis elegans Development

PubMed Central

Conradt, Barbara; Wu, Yi-Chun; Xue, Ding

2016-01-01

Programmed cell death is an integral component of Caenorhabditis elegans development. Genetic and reverse genetic studies in C. elegans have led to the identification of many genes and conserved cell death pathways that are important for the specification of which cells should live or die, the activation of the suicide program, and the dismantling and removal of dying cells. Molecular, cell biological, and biochemical studies have revealed the underlying mechanisms that control these three phases of programmed cell death. In particular, the interplay of transcriptional regulatory cascades and networks involving multiple transcriptional regulators is crucial in activating the expression of the key death-inducing gene egl-1 and, in some cases, the ced-3 gene in cells destined to die. A protein interaction cascade involving EGL-1, CED-9, CED-4, and CED-3 results in the activation of the key cell death protease CED-3, which is tightly controlled by multiple positive and negative regulators. The activation of the CED-3 caspase then initiates the cell disassembly process by cleaving and activating or inactivating crucial CED-3 substrates; leading to activation of multiple cell death execution events, including nuclear DNA fragmentation, mitochondrial elimination, phosphatidylserine externalization, inactivation of survival signals, and clearance of apoptotic cells. Further studies of programmed cell death in C. elegans will continue to advance our understanding of how programmed cell death is regulated, activated, and executed in general. PMID:27516615

The size distribution of interstellar grains

NASA Technical Reports Server (NTRS)

Witt, Adolf N.

1987-01-01

Three major areas involving interstellar grains were investigated. First, studies were performed of scattering in reflection nebulae with the goal of deriving scattering characteristics of dust grains such as the albedo and the phase function asymmetry throughout the visible and the ultraviolet. Secondly, studies were performed of the wavelength dependence of interstellar extinction designed to demonstrate the wide range of grain size distributions naturally occurring in individual clouds in different parts of the galaxy. And thirdly, studies were also performed of the ultraviolet powered emission of dust grains in the 0.5 to 1.0 micron wavelength range in reflection nebulae. Findings considered of major importance are highlighted.

77 FR 45599 - CED Rock Springs, Inc.; Supplemental Notice That Revised Market-Based Rate Tariff Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER02-2546-000; ER02-2546-001] CED Rock Springs, Inc.; Supplemental Notice That Revised Market- Based Rate Tariff Filing...-referenced proceeding of CED Rock Springs, Inc.'s tariff revision filing, noting that such filing includes a...

Young stars of low mass in the Gum nebula

NASA Technical Reports Server (NTRS)

Graham, J. A.; Heyer, Mark H.

1989-01-01

Observations are presented for four recently formed stars in the vicinity of the Gum nebula which are heavily obscured by surrounding dust and are associated with small reflection nebulae. HH46 is the only currently active star of the sample, and it is found to have a spectral type in the range of late G-early K, with superimposed emission lines of H-alpha, Ca II, Fe I, Fe II, and weak He I at near zero velocities. It is suggested that the observed scenario of low-mass stars in an older massive star environment may be analogous to the circumstances surrounding the birth of the sun.

Near infrared photographic sky survey - A field index

NASA Technical Reports Server (NTRS)

Rossano, G. S.; Craine, E. R.

1980-01-01

The book presents an index of previously cataloged objects located in the fields of the northern sky included in the Steward Observatory Near Infrared Photographic Sky Survey, which was intended to be used for identification purposes in an effort to locate extremely red objects. The objects included in the index were taken from 16 catalogs of bright nebulae, dark nebulae, infrared objects, reflection nebulae, supernova remnants and other objects, and appear with their corresponding field numbers, computed field center coordinates, object name and 1950 epoch equatorial coordinates, as well as supplementary descriptive information as available. An appendix is also provided in which the center coordinates of each field are listed.

Undernutrition in the Kora Mudi tribal population, West Bengal, India: a comparison of body mass index and mid-upper-arm circumference.

PubMed

Bisai, Samiran; Bose, Kaushik

2009-03-01

Undernutrition among adult tribal women is a major health problem in India. To compare the utility of two different anthropometric indicators of chronic energy deficiency (CED) among tribal Kora Mudi women and to determine which of these two is a better indicator of undernutrition. A cross-sectional study of 123 individuals was conducted. The body mass index (BMI) and mid-upper-arm circumference (MUAC) were used to evaluate CED. The prevalence of CED based on BMI less than 18.5 was 55.3%, and the prevalence of CED based on MUAC less than 22.0 cm was 51.2%. Both of these prevalence rates are classified in the very high-prevalence category (> or = 40%) and indicate a critical situation according to World Health Organization recommendations. Mean BMI increased significantly with higher quartile of MUAC. There was a significant difference in the prevalence of CED between the MUAC quartiles. The risk ratio for CED for women in the lowest quartile of MUAC was 9.33 compared with those in the highest quartile. There was a significant positive association between MUAC and BMI. Regression analysis demonstrated that MUAC had a significant positive impact on BMI; the percentage of the variation in BMI explained by MUAC was 52%. Logistic regression analysis demonstrated that overall, 82.11% of cases of CED were correctly classified with the use of MUAC. The use of MUAC correctly diagnosed 82.35% of cases of CED and 81.82% of women with normal nutritional status. This population was facing severe nutritional stress. With limited resources and in the absence of skilled manpower, it may be more appropriate to use MUAC for human population surveys, particularly among tribal populations of developing countries.

Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts.

PubMed

Yokosawa, Michiko; Sonoda, Yukihiko; Sugiyama, Shin-ichiro; Saito, Ryuta; Yamashita, Yoji; Nishihara, Masamichi; Satoh, Taku; Kumabe, Toshihiro; Yokoyama, Masayuki; Tominaga, Teiji

2010-08-01

Prognosis for the patients with glioblastoma, the most common malignant brain tumor, remains dismal. A major barrier to progress in treatment of glioblastoma is the relative inaccessibility of tumors to chemotherapeutic agents. Convection-enhanced delivery (CED) is a direct intracranial drug infusion technique to deliver chemotherapeutic agents to the central nervous system, circumventing the blood-brain barrier and reducing systemic side effects. CED can provide wider distribution of infused agents compared to simple diffusion. We have reported that CED of a polymeric micelle carrier system could yield a clinically relevant distribution of encapsulated agents in the rat brain. Our aim was to evaluate the efficacy of CED of polymeric micellar Am80, a synthetic agonist with high affinity to nuclear retinoic acid receptor, in a rat model of glioblastoma xenografts. We also used systemic administration of temozolomide, a DNA-alkylating agent, which has been established as the standard of care for newly diagnosed malignant glioma. U87MG human glioma cells were injected into the cerebral hemisphere of nude rats. Rats bearing U87MG xenografts were treated with CED of micellar Am80 (2.4 mg/m(2)) on day 7 after tumor implantation. Temozolomide (200 mg/m(2)/day) was intraperitoneally administered daily for 5 days, starting on day 7 after tumor implantation. CED of micellar Am80 provided significantly longer survival than the control. The combination of CED of micellar Am80 and systemic administration of temozolomide provided significantly longer survival than single treatment. In conclusion, temozolomide combined with CED of micellar Am80 may be a promising method for the treatment of malignant gliomas.

The excess infrared emission of Herbig Ae/Be stars - Disks or envelopes?

NASA Technical Reports Server (NTRS)

Hartmann, Lee; Kenyon, Scott J.; Calvet, Nuria

1993-01-01

It is suggested that the near-IR emission in many Herbig Ae/Be stars arises in surrounding dusty envelopes, rather than circumstellar disks. It is shown that disks around Ae/Be stars are likely to remain optically thick at the required accretion rates. It is proposed that the IR excesses of many Ae/Be stars originate in surrounding dust nebulae instead of circumstellar disks. It is suggested that the near-IR emission of the envelope is enhanced by the same processes that produce anomalous strong continuum emission at temperatures of about 1000 K in reflection nebulae surrounding hot stars. This near-IR emission could be due to small grains transiently heated by UV photons. The dust envelopes could be associated with the primary star or a nearby companion star. Some Ae/Be stars show evidence for the 3.3-6.3-micron emission features seen in reflection nebulae around hot stars, which lends further support to this suggestion.

Ultraviolet Imaging Telescope images of the reflection nebula NGC 7023 - Derivation of ultraviolet scattering properties of dust grains

NASA Technical Reports Server (NTRS)

Witt, Adolf N.; Petersohn, Jens K.; Bohlin, Ralph C.; O'Connell, Robert W.; Roberts, Morton S.; Smith, Andrew M.; Stecher, Theodore P.

1992-01-01

The Ultraviolet Imaging Telescope as part of the Astro-1 mission, was used to obtain high-resolution surface brightness distribution data in six ultraviolet wavelength bands for the bright reflection nebula NGC 7023. From the quantitative comparison of the measured surface brightness gradients ratios of nebular to stellar flux, and detail radial surface brightness profiles with corresponding data from the visible, two major conclusions results: (1) the scattering in the near- and far-ultraviolet in this nebula is more strongly forward-directed than in the visible; (2) the dust albedo in the ultraviolet for wavelengths not less than 140 nm is identical to that in the visible, with the exception of the 220 nm bump in the extinction curve. In the wavelengths region of the bump, the albedo is reduced by 25 to 30 percent in comparison with wavelengths regions both shorter and longer. This lower albedo is expected, if the bump is a pure absorption feature.

Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma.

PubMed

Futamura, Gen; Kawabata, Shinji; Nonoguchi, Naosuke; Hiramatsu, Ryo; Toho, Taichiro; Tanaka, Hiroki; Masunaga, Shin-Ichiro; Hattori, Yoshihide; Kirihata, Mitsunori; Ono, Koji; Kuroiwa, Toshihiko; Miyatake, Shin-Ichi

2017-01-23

Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-amino-3-fluorocyclobutane-1-carboxylic acid (ACBC)-BSH. ACBC is a tumor selective synthetic amino acid. The purpose of this study was to assess the biodistribution of ACBC-BSH and its therapeutic efficacy following Boron Neutron Capture Therapy (BNCT) of the F98 rat glioma. We evaluated the biodistribution of three boron-10 compounds, ACBC-BSH, BSH and boronophenylalanine (BPA), in vitro and in vivo, following intravenous (i.v.) administration and intratumoral (i.t.) convection-enhanced delivery (CED) in F98 rat glioma bearing rats. For BNCT studies, rats were stratified into five groups: untreated controls, neutron-irradiation controls, BNCT with BPA/i.v., BNCT with ACBC-BSH/CED, and BNCT concomitantly using BPA/i.v. and ACBC-BSH/CED. In vitro, ACBC-BSH attained higher cellular uptake F98 rat glioma cells compared with BSH. In vivo biodistribution studies following i.v. administration and i.t. CED of ACBC-BSH attained significantly higher boron concentrations than that of BSH, but much lower than that of BPA. However, following convection enhanced delivery (CED), ACBC-BSH attained significantly higher tumor concentrations than BPA. The i.t. boron-10 concentrations were almost equal between the ACBC-BSH/CED group and BPA/i.v. group of rats. The tumor/brain boron-10 concentration ratio was higher with ACBC-BSH/CED than that of BPA/i.v. group. Based on these data, BNCT studies were carried out in F98 glioma bearing rats using BPA/i.v. and ACBC-BSH/CED as the delivery agents. The corresponding mean survival times were 37.4 ± 2.6d and 44.3 ± 8.0d, respectively, and although modest, these differences were statistically significant. Our findings suggest that further studies are warranted to evaluate ACBC-BSH/CED as a boron delivery agent.

Young stars of low mass in the Gum nebula

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graham, J.A.; Heyer, M.H.

1989-06-01

Observations are presented for four recently formed stars in the vicinity of the Gum nebula which are heavily obscured by surrounding dust and are associated with small reflection nebulae. HH46 is the only currently active star of the sample, and it is found to have a spectral type in the range of late G-early K, with superimposed emission lines of H-alpha, Ca II, Fe I, Fe II, and weak He I at near zero velocities. It is suggested that the observed scenario of low-mass stars in an older massive star environment may be analogous to the circumstances surrounding the birthmore » of the sun. 53 refs.« less

Solution structure and interactions of the Escherichia coli cell division activator protein CedA.

PubMed

Chen, Ho An; Simpson, Peter; Huyton, Trevor; Roper, David; Matthews, Stephen

2005-05-10

CedA is a protein that is postulated to be involved in the regulation of cell division in Escherichia coli and related organisms; however, little biological data about its possible mode of action are available. Here we present a three-dimensional structure of this protein as determined by NMR spectroscopy. The protein is made up of four antiparallel beta-strands, an alpha-helix, and a large unstructured stretch of residues at the N-terminus. It shows structural similarity to a family of DNA-binding proteins which interact with dsDNA via a three-stranded beta-sheet, suggesting that CedA may be a DNA-binding protein. The putative binding surface of CedA is predominantly positively charged with a number of basic residues surrounding a groove largely dominated by aromatic residues. NMR chemical shift perturbations and gel-shift experiments performed with CedA confirm that the protein binds dsDNA, and its interaction is mediated primarily via the beta-sheet.

Are we there yet? A Practitioner's View of DO-178C/ED-12C

NASA Astrophysics Data System (ADS)

Daniels, Dewi

RTCA DO-178B/EUROCAE ED-12B is the industry-accepted guidance for determining that the software aspects of airborne systems and equipment comply with airworthiness requirements. DO-178B/ED-12B, published in 1992, is being updated to DO-178C/ED-12C. Nearly six years in the making, DO- 178C/ED-12C is expected to be completed in December 2010. It will be accompanied by a new set of supplements providing additional and much-needed guidance on tool qualification, model based development and verification, objectoriented technologies, and formal methods. Written by a member of the DO-178C/ED-12C editorial team who is also a practising software developer and verifier, this paper provides a practitioner's view of the new standard and its supplements. It explains how they will affect your organisation, focusing on the practical implications of the many changes between DO-178B/ED-12B and DO-178C/ED-12C.

Hypothalamic amenorrhea in a Camurati-Engelmann disease--a case report.

PubMed

Meczekalski, Blazej; Czyzyk, Adam; Podfigurna-Stopa, Agnieszka; Rydzewski, Bogdan; Sroczynski, Jakub; Lipinska, Małgorzata; Sokalski, Jerzy; Krawczynski, Maciej; Jamsheer, Aleksander; Katulski, Krzysztof; Genazzani, Alessandro

2013-05-01

A case report of a patient diagnosed with Camurati-Engelmann Disease (CED) in association with the functional hypothalamic amenorrhea disturbances. CED is a very rare genetically determined disorder classified as a type of bone dysplasia. Case report. Department of Gynecological Endocrinology, 3rd grade Medical University Hospital. Twenty-one years old female patient with CED admitted to the hospital because of primary amenorrhea. Her history revealed skeletal deformities and hearing impairment. Clinical examination, ultrasound, laboratory evaluations (including serum gonadotropins (FSH, LH) at basal state and after stimulation with gonadotropin-releasing hormone, serum basal estradiol) radiological studies (X-ray of the head, the lumbar spine and lower extremities; a computed tomography of the head), G-banding karyotype, polymerase chain reaction and DNA sequencing. Hormonal serum evaluations were made using an enzyme-linked immunosorbent assay. The exon 4 of the transforming growth factor beta 1 gene was amplified by a polymerase chain reaction and the product was directly sequenced. The hormonal analysis was characteristic for the hypogonadotropic hypogonadism. Radiological and molecular analyses confirmed CED diagnosis. The hypothalamic amenorrhea in a patient with CED may be explained as a consequence of fat hypotrophy and very low body mass index. Therefore, impairment within hypothalamic-pituitary axis in patients with CED should be treated with special attention.

Politics and its intersection with coverage with evidence development: a qualitative analysis from expert interviews.

PubMed

Bishop, Danielle; Lexchin, Joel

2013-03-09

Pressures on health care budgets have led policy makers to discuss how to balance the provision of costly technologies to populations in need and making coverage decisions under uncertainty. Coverage with evidence development (CED) is being employed to meet these challenges. Twenty-four interviews were carried out between June 2009 and December 2010 with researchers, decision makers and policy makers from Australia, Canada, United Kingdom and United States. Three phases of coding occurred, the first being manual coding where the interviews were read and notes were taken and nodes were extracted and imputed. NVIVO coding was applied to the interview transcripts, with both broad general searches for word usages and imputed nodes. Four overarching thematic areas emerged out of contextual analysis of the interviews - (1) what constitutes CED; (2) the lack of a systematic approach/governance structure; (3) the role of the pharmaceutical industry and overt political considerations in CED; and (4) alternatives and barriers to CED. We explore these themes and then use concrete examples of CED projects in each of the four countries to illustrate the political issues that our interviewees raised. Until the underlying political nature of CED is recognized then fundamental questions about its usefulness and operation will remain unresolved.

Politics and its intersection with coverage with evidence development: a qualitative analysis from expert interviews

PubMed Central

2013-01-01

Background Pressures on health care budgets have led policy makers to discuss how to balance the provision of costly technologies to populations in need and making coverage decisions under uncertainty. Coverage with evidence development (CED) is being employed to meet these challenges. Methods Twenty-four interviews were carried out between June 2009 and December 2010 with researchers, decision makers and policy makers from Australia, Canada, United Kingdom and United States. Three phases of coding occurred, the first being manual coding where the interviews were read and notes were taken and nodes were extracted and imputed. NVIVO coding was applied to the interview transcripts, with both broad general searches for word usages and imputed nodes. Results Four overarching thematic areas emerged out of contextual analysis of the interviews – (1) what constitutes CED; (2) the lack of a systematic approach/governance structure; (3) the role of the pharmaceutical industry and overt political considerations in CED; and (4) alternatives and barriers to CED. We explore these themes and then use concrete examples of CED projects in each of the four countries to illustrate the political issues that our interviewees raised. Conclusion Until the underlying political nature of CED is recognized then fundamental questions about its usefulness and operation will remain unresolved. PMID:23497271

Association between Farming and Chronic Energy Deficiency in Rural South India

PubMed Central

Subasinghe, Asvini K.; Walker, Karen Z.; Evans, Roger G.; Srikanth, Velandai; Arabshahi, Simin; Kartik, Kamakshi; Kalyanram, Kartik; Thrift, Amanda G.

2014-01-01

Objective To examine factors associated with chronic energy deficiency (CED) and anaemia in disadvantaged Indian adults who are mostly involved in subsistence farming. Design A cross-sectional study in which we collected information on socio-demographic factors, physical activity, anthropometry, blood haemoglobin concentration, and daily household food intake. These data were used to calculate body mass index (BMI), basal metabolic rate (BMR), daily energy expenditure, and energy and nutrient intake. Multivariable backward stepwise logistic regression was used to assess socioeconomic and lifestyle factors associated with CED (defined as BMI<18 kg/m2) and anaemia. Setting The study was conducted in 12 villages, in the Rishi Valley, Andhra Pradesh, India. Subjects Individuals aged 18 years and above, residing in the 12 villages, were eligible to participate. Results Data were available for 1178 individuals (45% male, median age 36 years (inter quartile range (IQR 27–50)). The prevalence of CED (38%) and anaemia (25%) was high. Farming was associated with CED in women (2.20, 95% CI: 1.39–3.49) and men (1.71, 95% CI: (1.06–2.74). Low income was also significantly associated with CED, while not completing high school was positively associated with anaemia. Median iron intake was high: 35.7 mg/day (IQR 26–46) in women and 43.4 mg/day (IQR 34–55) in men. Conclusions Farming is an important risk factor associated with CED in this rural Indian population and low dietary iron is not the main cause of anaemia. Better farming practice may help to reduce CED in this population. PMID:24475286

Uric acid is associated with inflammation, coronary microvascular dysfunction, and adverse outcomes in postmenopausal women

PubMed Central

Prasad, Megha; Matteson, Eric L.; Herrmann, Joerg; Gulati, Rajiv; Rihal, Charanjit S.; Lerman, Lilach O.; Lerman, Amir

2016-01-01

Uric acid is a risk factor for coronary artery disease (CAD) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction (CED) is not well-defined. The aim of this study was to determine the relationship of serum uric acid (SUA), inflammatory markers and CED. In this prospective cohort study, serum uric acid, hsCRP levels, and neutrophil count were measured in 229 postmenopausal women who underwent diagnostic catheterization, were found to have no obstructive CAD and underwent coronary microvascular function testing, to measure coronary blood flow (CBF) response to intracoronary acetylcholine. The average age was 58 years (IQR 52, 66) years. Hypertension was present in 48%, type 2 diabetes mellitus in 5.6%, and hyperlipidemia in 61.8%. CED was diagnosed in 59% of postmenopausal women. Mean uric acid level was 4.7 ± 1.3 mg/dL. Postmenopausal women with CED had significantly higher SUA compared to patients without CED (4.9 ± 1.3 vs. 4.4 ± 1.3 mg/dL; p=0.02). There was a significant correlation between SUA and % change in CBF to acetylcholine (p=0.009), and this correlation persisted in multivariable analysis. SUA levels were significantly associated with increased neutrophil count (p=0.02) and hsCRP levels (p=0.006) among patients with CED, but not those without CED. Serum uric acid is associated with coronary microvascular endothelial dysfunction in postmenopausal women and may be related to inflammation. These findings link serum uric acid levels to early coronary atherosclerosis in postmenopausal women. PMID:27993955

Effects of Colored Enrichment Devices on Circadian Metabolism and Physiology in Male Sprague-Dawley Rats.

PubMed

Wren-Dail, Melissa A; Dauchy, Robert T; Ooms, Tara G; Baker, Kate C; Blask, David E; Hill, Steven M; Dupepe, Lynell M; Bohm, Rudolf P

2016-01-01

Environmental enrichment (EE) gives laboratory animals opportunities to engage in species-specific behaviors. However, the effects of EE devices on normal physiology and scientific outcomes must be evaluated. We hypothesized that the spectral transmittance (color) of light to which rats are exposed when inside colored enrichment devices (CED) affects the circadian rhythms of various plasma markers. Pair-housed male Crl:SD rats were maintained in ventilated racks under a 12:12-h light:dark environment (265.0 lx; lights on, 0600); room lighting intensity and schedule remained constant throughout the study. Treatment groups of 6 subjects were exposed for 25 d to a colored enrichment tunnel: amber, red, clear, or opaque. We measured the proportion of time rats spent inside their CED. Blood was collected at 0400, 0800, 1200, 1600, 2000, and 2400 and analyzed for plasma melatonin, total fatty acids, and corticosterone. Rats spent more time in amber, red, and opaque CED than in clear tunnels. All tubes were used significantly less after blood draws had started, except for the clear tunnel, which showed no change in use from before blood sampling began. Normal peak nighttime melatonin concentrations showed significant disruption in the opaque CED group. Food and water intakes and body weight change in rats with red-tinted CED and total fatty acid concentrations in the opaque CED group differed from those in other groups. These results demonstrate that the color of CED altered normal circadian rhythms of plasma measures of metabolism and physiology in rats and therefore might influence the outcomes of scientific investigations.

The color of meteoritic hibonite - an indicator of oxygen fugacity

NASA Astrophysics Data System (ADS)

Ihinger, P. D.; Stolper, E.

1986-05-01

Hibonites similar in composition to those found in Ca-Al-rich inclusions change color from blue, to green, to orange, to nearly colorless as oxygen fugacity is increased at high temperature from below the iron-wustite buffer up to air. The development of the blue color is correlated with the growth of an absorption band at 715 nm in the optical spectra of the hibonites as the oxygen fugacity is reduced. The growth of this band is attributed to the increasing concentration of Ti(3+) in these hibonites with decreasing oxygen fugacity. The blue hibonites in meteorites reflect equilibration under reducing conditions based on the intensity of 715 nm band, it is estimated that the hibonite in the Blue Angel inclusion indicates an oxygen fugacity four to five orders of magnitude more oxidizing than that expected in the early solar nebula. This may be due to formation in an anomalously oxidizing region of the nebula or to oxidation during cooling or later alteration. The orange hibonites in Allende reflect oxygen fugacities approximately ten or more orders of magnitude more oxidizing than the expected primitive nebula; this color probably indicates alteration of initially more reduced (blue?) hibonites. The colorless hibonite in the HAL inclusion reflects highly oxidizing conditions and/or its low Ti content.

The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology

PubMed Central

Fiandaca, Massimo S.; Berger, Mitchel S.; Bankiewicz, Krystof S.

2011-01-01

Liposomes have long been effective delivery vehicles for transport of toxins to peripheral cancers. The combination of convection-enhanced delivery (CED) with liposomal toxins was originally proposed to circumvent the limited delivery of intravascular liposomes to the central nervous system (CNS) due to the blood-brain-barrier (BBB). CED offers markedly improved distribution of infused therapeutics within the CNS compared to direct injection or via drug eluting polymers, both of which depend on diffusion for parenchymal distribution. This review examines the basis for improved delivery of liposomal toxins via CED within the CNS, and discusses preclinical and clinical experience with these therapeutic techniques. How CED and liposomal technologies may influence future neurooncologic treatments are also considered. PMID:22069714

Interpretation of a Variable Reflection Nebula Associated with HBC 340 and HBC 341 in NGC 1333

NASA Astrophysics Data System (ADS)

Dahm, S. E.; Hillenbrand, L. A.

2017-11-01

We present multi-epoch, R-band imaging obtained from the Palomar Transient Factory of a small, fan-shaped reflection nebula in NGC 1333 that experiences prominent brightness fluctuations. Photometry of HBC 340 (K7e) and HBC 341 (M5e), a visual pair of late-type, young stellar objects lying near the apex of the nebula, demonstrates that while both are variable, the former has brightened by more than two magnitudes following a deep local minimum in 2014 September. Keck high-dispersion (R ˜ 45,000-66,000), optical spectroscopy of HBC 340 suggests that the protostar is a spectroscopic binary (HBC 340Aa + HBC 340Ab). Both HBC 340 and HBC 341 exhibit strong Hα and forbidden line emission, consistent with accretion and outflow. We conclude that the brightness fluctuations in the reflection nebula represent light echos produced by varying incident radiation emanating from HBC 340. The short-term variability observed in the protostar is attributed to irregular accretion activity, while correlated, dipping behavior on a several hundred day timescale may be due to eclipse-like events caused by orbiting circumstellar material. Archival Hubble Space Telescope imaging of the region reveals a second, faint (F814W ˜ 20.3 mag) companion to HBC 340 that lies 1.″02 (˜235 au) east of the protostar. If associated, this probable substellar mass object (20-50 Jupiter masses), HBC 340B, is likely unrelated to the observed brightness variations. The sustained brightening of HBC 340 since late 2014 can be explained by an EXor-like outburst, the recovery from a long duration eclipse event caused by obscuring circumstellar dust, or by the gradual removal of extincting material from along the line of sight. Our analysis here favors one of the extinction scenarios.

Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study.

PubMed

Green, Daniel M; Liu, Wei; Kutteh, William H; Ke, Raymond W; Shelton, Kyla C; Sklar, Charles A; Chemaitilly, Wassim; Pui, Ching-Hon; Klosky, James L; Spunt, Sheri L; Metzger, Monika L; Srivastava, DeoKumar; Ness, Kirsten K; Robison, Leslie L; Hudson, Melissa M

2014-10-01

Few data define the dose-specific relation between alkylating agent exposure and semen variables in adult survivors of childhood cancer. We undertook this study to test the hypothesis that increased exposure to alkylating agents would be associated with decreased sperm concentration in a cohort of adult male survivors of childhood cancer who were not exposed to radiation therapy for their childhood cancer. We did semen analysis on 214 adult male survivors of childhood cancer (median age 7·7 years [range 0·01-20·3] at diagnosis, 29·0 years [18·4-56·1] at assessment, and a median of 21·0 years [10·5-41·6] since diagnosis) who had received alkylating agent chemotherapy but no radiation therapy. Alkylating agent exposure was estimated using the cyclophosphamide equivalent dose (CED). Odds ratios (ORs) and 95% CIs for oligospermia (sperm concentration >0 and <15 million per mL) and azoospermia were calculated with logistic regression modelling. Azoospermia was noted in 53 (25%) of 214 participants, oligospermia in 59 (28%), and normospermia (sperm concentration ≥15 million per mL) in 102 (48%) participants. 31 (89%) of 35 participants who received CED less than 4000 mg/m(2) were normospermic. CED was negatively correlated with sperm concentration (correlation coefficient=-0·37, p<0·0001). Mean CED was 10 830 mg/m(2) (SD 7274) in patients with azoospermia, 8480 mg/m(2) (4264) in patients with oligospermia, and 6626 mg/m(2) (3576) in patients with normospermia. In multivariable analysis, CED was significantly associated with an increased risk per 1000 mg/m(2) CED for azoospermia (OR 1·22, 95% CI 1·11-1·34), and for oligospermia (1·14, 1·04-1·25), but age at diagnosis and age at assessment were not. Impaired spermatogenesis was unlikely when the CED was less than 4000 mg/m(2). Although sperm concentration decreases with increasing CED, there was substantial overlap of CED associated with normospermia, oligospermia, and azoospermia. These data can inform pretreatment patient counselling and use of fertility preservation services. US National Cancer Institute, American Lebanese Syrian Associated Charities. Copyright © 2014 Elsevier Ltd. All rights reserved.

Celiac disease and other autoimmune diseases in patients with collagenous colitis.

PubMed

Vigren, Lina; Tysk, Curt; Ström, Magnus; Kilander, Anders F; Hjortswang, Henrik; Bohr, Johan; Benoni, Cecilia; Larson, Lasse; Sjöberg, Klas

2013-08-01

Collagenous colitis (CC) is associated with autoimmune disorders. The aim of the present study was to investigate the relationship between CC and autoimmune disorders in a Swedish multicenter study. Patients with CC answered questionnaires about demographic data and disease activity. The patient's files were scrutinized for information about autoimmune diseases. A total number of 116 CC patients were included; 92 women, 24 men, median age 62 years (IQR 55-73). In total, 30.2% had one or more autoimmune disorder. Most common were celiac disease (CeD; 12.9%) and autoimmune thyroid disease (ATD, 10.3%), but they also had Sjögren's syndrome (3.4%), diabetes mellitus (1.7%) and conditions in skin and joints (6.0%). Patients with associated autoimmune disease had more often nocturnal stools. The majority of the patients with associated CeD or ATD got these diagnoses before the colitis diagnosis. Autoimmune disorders occurred in one-third of these patients, especially CeD. In classic inflammatory bowel disease (IBD), liver disease is described in contrast to CC where no cases occurred. Instead, CeD was prevalent, a condition not reported in classic IBD. Patients with an associated autoimmune disease had more symptoms. Patients with CC and CeD had an earlier onset of their colitis. The majority of the patients with both CC and CeD were smokers. Associated autoimmune disease should be contemplated in the follow-up of these patients.

Factors associated with nutritional status among adult women in urban India, 1998-2006.

PubMed

Rai, Rajesh Kumar

2015-03-01

This study attempts to understand the factors associated with chronic energy deficiency (CED) and overweight/obesity together with change in CED and overweight/obesity among urban Indian women during 1998-2006. Both National Family Health Survey (NFHS) 1998-1999 and NFHS 2005-2006 data sets were used. The standard cutoff points for both CED (BMI < 18.5 kg/m(2)) and overweight/obesity (BMI ≥ 23 kg/m(2)) were considered. The Phi and Cramer's V tests and predicted probabilities were used to fulfill the study objective. Results indicate an almost 3% reduction in CED and a 6% increase in overweight/obesity during 1998-2006. The probability of CED has reduced among nonliterate women and women belonging to the poorest wealth quintile; on the other hand, the likelihood of being overweight/obese has increased among women with high school education and above and women belonging to the richest wealth quintile. Interventions to promote physical activities and nutritional awareness programs, which are effective in addressing nutritional problems, have been proposed. © 2012 APJPH.

Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective.

PubMed

Krauze, Michal T; Vandenberg, Scott R; Yamashita, Yoji; Saito, Ryuta; Forsayeth, John; Noble, Charles; Park, John; Bankiewicz, Krystof S

2008-04-01

Convection-enhanced delivery (CED) is gaining popularity in direct brain infusions. Our group has pioneered the use of liposomes loaded with the MRI contrast reagent as a means to track and quantitate CED in the primate brain through real-time MRI. When co-infused with therapeutic nanoparticles, these tracking liposomes provide us with unprecedented precision in the management of infusions into discrete brain regions. In order to translate real-time CED into clinical application, several important parameters must be defined. In this study, we have analyzed all our cumulative animal data to answer a number of questions as to whether real-time CED in primates depends on concentration of infusate, is reproducible, allows prediction of distribution in a given anatomic structure, and whether it has long term pathological consequences. Our retrospective analysis indicates that real-time CED is highly predictable; repeated procedures yielded identical results, and no long-term brain pathologies were found. We conclude that introduction of our technique to clinical application would enhance accuracy and patient safety when compared to current non-monitored delivery trials.

Complications associated with cervical endoscopic discectomy with the holmium laser.

PubMed

Haufe, Scott M W; Mork, Anthony R

2004-02-01

Our aim was to determine the rate of surgical complications associated with cervical endoscopic discectomy (CED). There are no studies that state the degree of complications after CED. Forty-one patients underwent CED with holmium laser. Two out of 41 patients incurred vascular compromise during the procedure. One patient developed recurrent laryngeal nerve damage. One patient developed discitis, and two patients complained of a "clicking" sensation postoperatively. Although CED has a relatively high success rate, there is a 15% rate of complications associated with the procedure. Most of the complications were minor (such as vascular compromise, recurrent laryngeal nerve injury, and postoperative "clicking" sensations), but there was one case of severe discitis, and there is the potential of serious complication from both vascular compromise and neural injury.

Aperture-synthesis observations of carbon monoxide in the Egg Nebula

NASA Technical Reports Server (NTRS)

Heiligman, G. M.; Berge, G. L.; Claussen, M. J.; Leighton, R. B.; Lo, K. Y.; Masson, C. R.; Moffet, A. T.; Phillips, T. G.; Sargent, A. I.; Wannier, P. G.

1986-01-01

Observations of the 2.6-mm CO emission of the bipolar nebular CRL 2688, obtained with resolution 7 arcsec using the mm-wave interferometer at Owens Valley during December 1982-June 1983, are reported. The emission of a 10 x 15-arcsec core, centered on the optical reflection nebula and probably surrounded by a large cloud of cooler gas, is found to have a main-axis velocity gradient of 3 km/s arcsec and an excitation temperature of about 70 K.

Hubble Watches Super Star Create Holiday Light Show

NASA Image and Video Library

2017-12-08

This festive NASA Hubble Space Telescope image resembles a holiday wreath made of sparkling lights. The bright southern hemisphere star RS Puppis, at the center of the image, is swaddled in a gossamer cocoon of reflective dust illuminated by the glittering star. The super star is ten times more massive than our sun and 200 times larger. RS Puppis rhythmically brightens and dims over a six-week cycle. It is one of the most luminous in the class of so-called Cepheid variable stars. Its average intrinsic brightness is 15,000 times greater than our sun’s luminosity. The nebula flickers in brightness as pulses of light from the Cepheid propagate outwards. Hubble took a series of photos of light flashes rippling across the nebula in a phenomenon known as a "light echo." Even though light travels through space fast enough to span the gap between Earth and the moon in a little over a second, the nebula is so large that reflected light can actually be photographed traversing the nebula. By observing the fluctuation of light in RS Puppis itself, as well as recording the faint reflections of light pulses moving across the nebula, astronomers are able to measure these light echoes and pin down a very accurate distance. The distance to RS Puppis has been narrowed down to 6,500 light-years (with a margin of error of only one percent). The Hubble Space Telescope is a project of international cooperation between NASA and the European Space Agency. NASA's Goddard Space Flight Center in Greenbelt, Md., manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Md., conducts Hubble science operations. STScI is operated by the Association of Universities for Research in Astronomy, Inc., in Washington, D.C. Acknowledgment: H. Bond (STScI and Pennsylvania State University) NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

13 CFR 307.5 - Application requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ECONOMIC ADJUSTMENT ASSISTANCE INVESTMENTS General § 307.5 Application requirements. (a) Each application... EDA) a CEDS, except that a CEDS is not required when applying for a Strategy Grant; and (2) Explain...

CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication.

PubMed

Katayama, T; Takata, M; Sekimizu, K

1997-11-01

We isolated and characterized a new gene related to the control of cell division regulation in Escherichia coli. At 30 degrees C, the dnaAcos mutant causes over-replication of the chromosome, and colony formation is inhibited. We found that, at this temperature, the dnaAcos cells form filaments; therefore, septum formation is inhibited. This inhibition was independent of SfiA, an inhibitor of the septum-forming protein, FtsZ. To identify factors involved in this pathway of inhibition, we isolated seven multicopy suppressors for the cold-sensitive phenotype of the dnaAcos mutant. One of these proved to be a previously unknown gene, which we named cedA. This gene encoded a 12 kDa protein and resided at 38.9min on the E. coli genome map. A multicopy supply of the cedA gene to the dnaAcos cells did not repress over-replication of the chromosome but did stimulate cell division of the host, the result being growth of cells with an abnormally elevated chromosomal copy number. Therefore, the expression level of the cedA gene seems to be important for inhibiting cell division of the dnaAcos mutant at 30 degrees C. We propose that over-replication of the chromosome activates a pathway for inhibiting cell division and that the cedA gene modulates this division control. In the dnaA+ background, cedA also seems to affect cell division.

Near infrared photometric and optical spectroscopic study of 22 low mass star clusters embedded in nebulae

NASA Astrophysics Data System (ADS)

Soares, J. B.; Bica, E.; Ahumada, A. V.; Clariá, J. J.

2008-02-01

Aims:Among the star clusters in the Galaxy, those embedded in nebulae represent the youngest group, which has only recently been explored. The analysis of a sample of 22 candidate embedded stellar systems in reflection nebulae and/or HII environments is presented. Methods: We employed optical spectroscopic observations of stars in the directions of the clusters carried out at CASLEO (Argentina) together with near infrared photometry from the 2MASS catalogue. Our analysis is based on source surface density, colour-colour diagrams and on theoretical pre-main sequence isochrones. We take into account the field star contamination by carrying out a statistical subtraction. Results: The studied objects have the characteristics of low mass systems. We derive their fundamental parameters. Most of the cluster ages are younger than 2 Myr. The studied embedded stellar systems in reflection nebulae and/or HII region complexes do not have stars of spectral types earlier than B. The total stellar masses locked in the clusters are in the range 20-220 M⊙. They are found to be gravitationally unstable and are expected to dissolve in a timescale of a few Myr. Based on observations made at Complejo Astronómico El Leoncito, which is operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the National Universities of La Plata, Córdoba and San Juan, Argentina.

NEAR-INFRARED CIRCULAR AND LINEAR POLARIMETRY OF MONOCEROS R2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwon, Jungmi; Tamura, Motohide; Hough, James H.

We have conducted simultaneous JHK{sub s}-band imaging circular and linear polarimetry of the Monoceros R2 (Mon R2) cluster. We present results from deep and wide near-infrared linear polarimetry of the Mon R2 region. Prominent and extended polarized nebulosities over the Mon R2 field are revisited, and an infrared reflection nebula associated with the Mon R2 cluster and two local reflection nebulae, vdB 67 and vdB 69, is detected. We also present results from deep imaging circular polarimetry in the same region. For the first time, the observations show relatively high degrees of circular polarization (CP) in Mon R2, with asmore » much as approximately 10% in the K{sub s} band. The maximum CP extent of a ring-like nebula around the Mon R2 cluster is approximately 0.60 pc, while that of a western nebula, around vdB 67, is approximately 0.24 pc. The extended size of the CP is larger than those seen in the Orion region around IRc2, while the maximum degree of CP of ∼10% is smaller than those of ∼17% seen in the Orion region. Nonetheless, both the CP size and degree of this region are among the largest in our infrared CP survey of star-forming regions. We have also investigated the time variability of the degree of the polarization of several infrared sources and found possible variations in three sources.« less

Near-Infrared Polarimetry of the Eagle Nebula (M 16)

NASA Astrophysics Data System (ADS)

Sugitani, Koji; Watanabe, Makoto; Tamura, Motohide; Kandori, Ryo; Hough, James H.; Nishiyama, Shogo; Nakajima, Yasushi; Kusakabe, Nobuhiko; Hashimoto, Jun; Nagayama, Takahiro; Nagashima, Chie; Kato, Daisuke; Fukuda, Naoya

2007-06-01

We carried out deep and wide (˜ 8 × 8) JHKs imaging polarimetry in the southern region of the Eagle Nebula (M 16). The polarization intensity map reveals that two YSOs with near-IR reflection nebulae are located at the tips of two famous molecular pillars (Pillars 1 and 2) facing toward the exciting stars of M 16. The centrosymmetric polarization pattern are consistent with those around Class I objects having circumstellar envelopes, confirming that star formation is now taking place at the two tips of the pillars under the influence of UV radiation from the exciting stars. Polarization measurements of point sources show that magnetic fields are aligned along some of the pillars, but in a direction that is quite different to the global structure in M 16.

Photometry and Classification of Stars around the Reflection Nebula NGC 7023 IN Cepheus. II. Interstellar Extinction and Cloud Distances

NASA Astrophysics Data System (ADS)

Zdanavičius, K.; Zdanavičius, J.; Straižys, V.; Maskoliūnas, M.

Interstellar extinction is investigated in a 1.5 square degree area in the direction of the reflection nebula NGC 7023 at ℓ = 104.1\\degr, b = +14.2\\degr. The study is based on photometric classification and the determination of interstellar extinctions and distances of 480 stars down to V = 16.5 mag from photometry in the Vilnius seven-color system published in Paper I (2008). The investigated area is divided into five smaller subareas with slightly different dependence of the extinction on distance. The distribution of reddened stars is in accordance with the presence of two dust clouds at 282 pc and 715 pc, however in some directions the dust distribution can be continuous or more clouds can be present.

Antenatal and Postnatal Psychopathology Among Women with Current and Past Eating Disorders: Longitudinal Patterns

PubMed Central

Easter, Abigail; Solmi, Francessca; Bye, Amanda; Taborelli, Emma; Corfield, Freya; Schmidt, Ulrike; Treasure, Janet; Micali, Nadia

2015-01-01

This study aims to investigate longitudinal patterns of psychopathology during the antenatal and postnatal periods among women with current (C-ED) and past (P-ED) eating disorders. Women were recruited to a prospective longitudinal study: C-ED (n = 31), P-ED (n = 29) and healthy control (HC; n = 57). Anxiety, depression and ED symptoms were measured at four time points: first/second trimester, third trimester, 8 weeks and 6 months postpartum. Linear mixed effects models were used to test for group differences. Women with C-ED and P-ED, in all diagnostic categories, had significantly higher levels of psychopathology at all time points. ED symptoms decreased in the C-ED group, compared with an overall increase in the other two groups but subsequently increased after pregnancy. Overall, depression and state and trait anxiety scores decreased in the C-ED group compared with the HC group throughout the antenatal and postnatal periods. High levels of psychopathology are common throughout the antenatal and postnatal periods among women with current and past ED, and despite some overall reductions, symptoms remain clinically significant. © 2014 The Authors. European Eating Disorders Review published by John Wiley & Sons, Ltd. PMID:25345371

Convection-enhanced delivery for the treatment of glioblastoma

PubMed Central

Vogelbaum, Michael A.; Aghi, Manish K.

2015-01-01

Effective treatment of glioblastoma (GBM) remains a formidable challenge. Survival rates remain poor despite decades of clinical trials of conventional and novel, biologically targeted therapeutics. There is considerable evidence that most of these therapeutics do not reach their targets in the brain when administered via conventional routes (intravenous or oral). Hence, direct delivery of therapeutics to the brain and to brain tumors is an active area of investigation. One of these techniques, convection-enhanced delivery (CED), involves the implantation of catheters through which conventional and novel therapeutic formulations can be delivered using continuous, low–positive-pressure bulk flow. Investigation in preclinical and clinical settings has demonstrated that CED can produce effective delivery of therapeutics to substantial volumes of brain and brain tumor. However, limitations in catheter technology and imaging of delivery have prevented this technique from being reliable and reproducible, and the only completed phase III study in GBM did not show a survival benefit for patients treated with an investigational therapeutic delivered via CED. Further development of CED is ongoing, with novel catheter designs and imaging approaches that may allow CED to become a more effective therapeutic delivery technique. PMID:25746090

New French Coverage with Evidence Development for Innovative Medical Devices: Improvements and Unresolved Issues.

PubMed

Martelli, Nicolas; van den Brink, Hélène; Borget, Isabelle

2016-01-01

We describe here recent modifications to the French Coverage with Evidence Development (CED) scheme for innovative medical devices. CED can be defined as temporary coverage for a novel health product during collection of the additional evidence required to determine whether definitive coverage is possible. The principle refinements to the scheme include a more precise definition of what may be considered an innovative product, the possibility for device manufacturers to request CED either independently or in partnership with hospitals, and the establishment of processing deadlines for health authorities. In the long term, these modifications may increase the number of applications to the CED scheme, which could lead to unsustainable funding for future projects. It will also be necessary to ensure that the study conditions required by national health authorities are suitable for medical devices and that processing deadlines are met for the scheme to be fully operational. Overall, the modifications recently applied to the French CED scheme for innovative medical devices should increase the transparency of the process, and therefore be more appealing to medical device manufacturers. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Sequential testing with different tissue transglutaminase antibodies, a new approach for diagnosis of celiac disease.

PubMed

Venugopal, Giriprasad; Mechenro, John; Makharia, Govind; Singh, Alka; Pugazhendhi, Srinivasan; Balamurugan, Ramadass; Ramakrishna, Balakrishnan S

2017-11-01

The diagnosis of celiac disease (CeD) in clinical practice relies on serological testing for IgA antibodies to human tissue transglutaminase (anti-tTG) which diagnose CeD autoimmunity. We compared three kits for their performance in diagnosis of the disease and evaluated the point prevalence of CeD autoimmunity in a South Indian urban population. In the first part of the study, sera from 90 patients with documented CeD and 92 healthy controls were tested for anti-tTG using three different kits. One thousand nine hundred and seventeen healthy adults residing in urban areas of Vellore and Kancheepuram districts were tested for CeD autoimmunity using a sequential two-test strategy. The sensitivity, specificity, false positivity, false negativity, positive predictive value, and negative predictive value for the three assays respectively were as follows: 95.5%, 82.6%, 17.3%, 4.4%, 84.3%, and 95% for the Aeskulisa New Generation Assay; 85.5%, 100%, 0%, 14.4%, 100%, and 87.6% for Quanta Lite; and 71.1%, 100%, 0%, 28.8%, 100%, and 71% for Celiac Microlisa. The ROC curves showed good discrimination for all three ELISAs with an AUC of 0.947, 0.950, and 0.886 for the Aeskulisa, Quanta Lite, and Celiac Microlisa, respectively. Of 1917 (males 908, females 1009) healthy adults, 113 (5.89%) were seropositive for IgA anti-htTG in the Aeskulisa test. Two of the latter tested positive in the Quanta Lite assay and/or the Celiac Microlisa assay. The CeD autoimmunity prevalence in this urban population was 1.0 per thousand (95% confidence interval 0.3 to 3.7 per thousand). Sequential testing for anti-tTG using first a highly sensitive assay followed by a very specific assay is a new strategy for screening for CeD in clinical practice.

Corneal endothelial cell loss and corneal biomechanical characteristics after two-step sequential or combined phaco-vitrectomy surgery for idiopathic epiretinal membrane.

PubMed

Hamoudi, Hassan; Christensen, Ulrik Correll; La Cour, Morten

2017-08-01

To assess the impact of sequential and combined surgery [cataract surgery and 23-gauge pars plana vitrectomy (PPV) with peeling] on corneal endothelium cell density (CED) and corneal biomechanical characteristics. Phakic eyes with epiretinal membrane (ERM) were prospectively allocated to (i) cataract surgery and subsequent PPV (CAT group), (ii) PPV and subsequent cataract surgery (VIT group) or (iii) phacovitrectomy (COMBI group). Eyes were examined at baseline, 1 month after each surgery, and at 3 and 12 months follow-up. Corneal endothelium cell density (CED) was assessed with non-contact specular microscopy. Pachymetry [central cornea thickness (CCT)], keratometry and cornea volume (CV) were measured with Pentacam Scheimpflug camera. Primary outcome was change in CED after 12 months; secondary outcomes were changes in CCT and CV after 12 months. Sixty-two eyes were enrolled and allocated to the three groups. The mean preoperative CED was 2776, 2794 and 2653 cells/mm 2, which decreased significantly at 12 months by 15.3, 20.0 and 19.3% in the CAT, VIT and COMBI group. There was no significant difference in percentage cell loss between the groups at final follow-up. The CED decreased significantly after cataract surgery, but was unaffected by PPV. Central cornea thickness (CCT) increased by 10 μm (p = 0.005) and CV by 1.38 mm 3 (2.3%, p < 0.001) in the COMBI group. There were no significant differences in CCT or CV between the groups at final follow-up. Combined and sequential surgery in ERM leads to a small decrease in CED. Performing cataract surgery before, after or in combination with vitrectomy did not make any significant difference with respect to final CED, CCT or CV. © 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Synthesis and structural characterization of CdS nanoparticles using nitrogen adducts of mixed diisopropylthiourea and dithiolate derivatives of Cd(II) complexes

NASA Astrophysics Data System (ADS)

Osuntokun, Jejenija; Ajibade, Peter A.

2015-07-01

[Cd(diptu)2(ced)], [Cd(diptu)2(ced)(bpy)], [Cd(diptu)2(ced)(phen)], (where diptu = diisopropyl thiourea; ced = 1-cyano-1-carboethoxylethylene-2,2‧-dithiolate; bpy = 2,2‧-bipyridine and phen = 1,10-phenanthroline) have been prepared and used as single source precursors for the preparation of hexadecylamine capped CdS nanoparticles. The precursor complexes were characterized by elemental analysis, FTIR and TGA. The structural properties of the nanoparticles were investigated using powder X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy techniques (SEM). The optical properties of the nanoparticles were studied using UV-Visible and photoluminescence spectroscopy. The XRD analysis showed that the nanoparticles were indexed to the hexagonal phase of CdS and the TEM results showed CdS nanoparticles with average crystallite sizes of 4.00-8.80 nm.

Convection Enhanced Delivery of Recombinant Adeno-associated Virus into the Mouse Brain.

PubMed

Nash, Kevin R; Gordon, Marcia N

2016-01-01

Recombinant adeno-associated virus (rAAV) has become an extremely useful tool for the study of gene over expression or knockdown in the central nervous system of experimental animals. One disadvantage of intracranial injections of rAAV vectors into the brain parenchyma has been restricted distribution to relatively small volumes of the brain. Convection enhanced delivery (CED) is a method for delivery of clinically relevant amounts of therapeutic agents to large areas of the brain in a direct intracranial injection procedure. CED uses bulk flow to increase the hydrostatic pressure and thus improve volume distribution. The CED method has shown robust gene transfer and increased distribution within the CNS and can be successfully used for different serotypes of rAAV for increased transduction of the mouse CNS. This chapter details the surgical injection of rAAV by CED into a mouse brain.

Removal and recovery of inhibitory volatile fatty acids from mixed acid fermentations by conventional electrodialysis.

PubMed

Jones, Rhys Jon; Massanet-Nicolau, Jaime; Guwy, Alan; Premier, Giuliano C; Dinsdale, Richard M; Reilly, Matthew

2015-08-01

Hydrogen production during dark fermentation is inhibited by the co-production of volatile fatty acids (VFAs) such as acetic and n-butyric acid. In this study, the effectiveness of conventional electrodialysis (CED) in reducing VFA concentrations in model solutions and hydrogen fermentation broths is evaluated. This is the first time CED has been reported to remove VFAs from hydrogen fermentation broths. During 60 min of operation CED removed up to 99% of VFAs from model solutions, sucrose-fed and grass-fed hydrogen fermentation broths, containing up to 1200 mg l(-1) each of acetic acid, propionic acid, i-butyric acid, n-butyric acid, i-valeric acid, and n-valeric acid. CED's ability to remove VFAs from hydrogen fermentation broths suggests that this technology is capable of improving hydrogen yields from dark fermentation. Copyright © 2015 Elsevier Ltd. All rights reserved.

Do the Infrared Emission Features Need UV Excitation? The PAH Model in UV-poor Reflection Nebulae

NASA Astrophysics Data System (ADS)

Li, A.; Draine, B. T.

2001-12-01

One of the major challenges of identifying the 3.3, 6.2, 7.7, 8.6, and 11.3μ m interstellar infrared emission bands with polycyclic aromatic hydrocarbon (PAH) molecules has been the recent detection of these bands in regions with little ultraviolet (UV) illumination since small, neutral PAH molecules have little or no absorption at visible wavelengths and thus are excited primarily by UV photons. The ``astronomical'' PAH model (Li & Draine 2001), incorporating the experimental result that the visual absorption edge shifts to longer wavelength upon ionization and/or as the PAH size increases (Allamandola, Hudgins, & Sandford 1999), is shown to be able to closely reproduce the observed infrared emission bands of vdB 133, a UV-poor reflection nebula (Uchida, Sellgren, & Werner 1998) as well as the 6.2, 7.7, and 11.3μ m band ratios of the UV-deficient ring in the Andromeda galaxy M31 (Pagani et al. 1999). It is also shown that ``astronomical'' PAHs can be heated sufficiently by a T eff=3000 K black-body to emit at 6.2, 7.7, 8.6, and 11.3μ m. Illustrative mid-IR emission spectra are calculated for reflection nebulae illuminated by cool stars with T eff=3600, 4500, 5000 K. These will allow comparison with future Space Infrared Telescope Facility (SIRTF) observations of vdB 135 (T eff=3600 K), vdB 47 (T eff=4500 K), and vdB 101 (T eff=5000 K) (Houck 2001). This research was supported in part by NASA grant NAG5-7030 and NSF grant AST-9619429. { References:} Allamandola, L.J., Hudgins, D.M., & Sandford, S.A. 1999, ApJ, 511, L115 Houck, J.R. 2001, SIRTF Observations of the Mid IR Features in Reflection Nebulae, {\\sf http://sirtf.caltech.edu/ROC/pid19} Li, A., & Draine, B.T. 2001, ApJ, 554, 778 Pagani, L., et al. 1999, A&A, 351, 447 Uchida, K.I., Sellgren, K., & Werner, M.W. 1998, ApJ, 493, L109

Multiple Nebular Gas Reservoirs Recorded by Oxygen Isotope Variation in a Spinel-rich CAI in CO3 MIL 090019

NASA Technical Reports Server (NTRS)

Simon, J. I.; Simon, S. B.; Nguyen, A. N.; Ross, D. K.; Messenger, S.

2017-01-01

We conducted NanoSIMS O-isotopic imaging of a primitive spinel-rich CAI spherule (27-2) from the MIL 090019 CO3 chondrite. Inclusions such as 27-2 are proposed to record inner nebula processes during an epoch of rapid solar nebula evolution. Mineralogical and textural analyses suggest that this CAI formed by high temperature reactions, partial melting, and condensation. This CAI exhibits radial O-isotopic heterogeneity among multiple occurrences of the same mineral, reflecting interactions with distinct nebular O-isotopic reservoirs.

Undernutrition among adult Bengalees of Dearah, Hooghly District, West Bengal, India: relationship with educational status and food habit.

PubMed

Bose, Kaushik; Bisai, Samiran; Sadhukhan, Sanjay; Mukhopadhyay, Ashish; Bhadra, Mithu

2009-06-01

A cross-sectional study of 1203 adult (> 18 years of age) Bengalees of Dearah, Hooghly District, West Bengal, India, was undertaken to evaluate the prevalence of undernutrition and the relationship of educational level and food habit with undernutrition. Height and weight were measured and body mass index (BMI) computed following the standard equation. A BMI < 18.5 kg/m2 was classified as undernutrition or chronic energy deficiency (CED) as per World Health Organization (WHO) recommendations. The public health problem of low BMI in this population was classified according to the WHO criteria. Educational status was coded as: no formal education, 1-8 years of schooling and > 8 years of schooling. Food habit was recorded as vegetarian or non-vegetarian. The mean ages of males and females were (39.6 +/- 15.0 years) and (39.6 +/- 15.0 years), respectively. There were significant (p < 0.001) sex differences in mean height and weight; both sexes had a similar BMI. The overall (sex combined) prevalence of undernutrition was 27.7%. The frequency of undernutrition was significantly (p < 0.001) higher among females (31.7%) compared to males (23.6%). According to the WHO classification of low BMI, the prevalence of CED was high (20-39%) indicating a serious situation. There existed a significant (p < 0.001) relationship between the level of formal education and nutritional status. Overall, the frequencies of CED (43.5%) were much higher than overweight (7.0%) among subjects with no formal education. The frequencies of CED and overweight among subjects with 1-8 years of formal education were 25.7% and 9.7%, respectively. Similarly, significantly (p < 0.001) higher rates of CED were found among subjects with no formal education in both sexes (males = 39.5%; females = 45.6%) compared to the presence of overweight (males = 1.8%; females = 9.8%). Sex-combined frequency of undernutrition was significantly (p < 0.001) higher among vegetarians (48.3%) compared with non-vegetarians (25.5%). The respective frequencies of overweight were 1.7% and 12.8%. This significant (p < 0.001) trend existed in both sexes with 46.9% male and 49.3% female vegetarians having CED. The corresponding figures for overweight among vegetarians were 0.0% and 2.9%, respectively. The rates of CED were significantly (p < 0.001) lower among non-vegetarians (males = 21.5%; females = 29.6%). Non-vegetarians had significantly higher rates of overweight in both males (8.7%) and females (16.9%). Multiple regression analysis revealed that both educational status as well as food habit had significant effect on BMI in both sexes. In general, the educational status had a stronger impact (males: t = 6.356, females: t = 5.017) than food habit (males: t = 3.373; females: t = 2.763) on BMI. This significant impact remained even after controlling for the effect of age. In conclusion, this study demonstrated that adult Bengalees of Dearah were under serious nutritional stress indicating a public health problem. In addition, a strong inverse relationship existed between educational level and CED. Moreover, vegetarianism was significantly associated with CED. Urgent public health measures are required, particularly among females, to reduce the high prevalence of CED in this population. Similar studies should be conducted in other parts of West Bengal before any general conclusions can be inferred about the relationship between educational status, food habit and CED in the state.

Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery.

PubMed

Varenika, Vanja; Dickinson, Peter; Bringas, John; LeCouteur, Richard; Higgins, Robert; Park, John; Fiandaca, Massimo; Berger, Mitchel; Sampson, John; Bankiewicz, Krystof

2008-11-01

The authors have shown that convection-enhanced delivery (CED) of gadoteridol-loaded liposomes (GDLs) into different regions of normal monkey brain results in predictable, widespread distribution of this tracking agent as detected by real-time MR imaging. They also have found that this tracking technique allows monitoring of the distribution of similar nanosized agents such as therapeutic liposomes and viral vectors. A limitation of this procedure is the unexpected leakage of liposomes out of targeted parenchyma or malignancies into sulci and ventricles. The aim of the present study was to evaluate the efficacy of CED after the onset of these types of leakage. The authors documented this phenomenon in a study of 5 nonhuman primates and 7 canines, comprising 54 CED infusion sessions. Approximately 20% of these infusions resulted in leakage into cerebral ventricles or sulci. All of the infusions and leakage events were monitored with real-time MR imaging. The authors created volume-distributed versus volume-infused graphs for each infusion session. These graphs revealed the rate of distribution of GDL over the course of each infusion and allowed the authors to evaluate the progress of CED before and after leakage. The distribution of therapeutics within the target structure ceased to increase or resulted in significant attenuation after the onset of leakage. An analysis of the cases in this study revealed that leakage undermines the efficacy of CED. These findings reiterate the importance of real-time MR imaging visualization during CED to ensure an accurate, robust distribution of therapeutic agents.

Convection-enhancement delivery of platinum-based drugs and Lipoplatin™ to optimize the concomitant effect with radiotherapy in F98 glioma rat model

PubMed Central

Shi, Minghan; Fortin, David; Sanche, Léon; Paquette, Benoit

2015-01-01

The prognosis for patients with glioblastoma remains poor with current treatments. Although platinum based drugs are sometimes offered at relapse, their efficacy in this setting is still disputed. In this study, we use convection-enhanced delivery (CED) to deliver the platinum-based drugs (cisplatin, carboplatin, and Lipoplatin™-liposomal formulation of cisplatin) directly into the tumor of F98 glioma-bearing rats that were subsequently treated with γ radiation (15 Gy). CED increased by factors varying between 17 and 111, the concentration of these platinum-based drugs in the brain tumor compared to intra-venous (i.v.) administration, and by 9- to 34-fold, when compared to intra-arterial (i.a.) administration. Furthermore, CED resulted in a better systemic tolerance to platinum drugs compared to their i.a. injection. Among the drugs tested, carboplatin showed the highest maximum tolerated dose (MTD). Treatment with carboplatin resulted in the best median survival time (MeST) (38.5 days), which was further increased by the addition of radiotherapy (54.0 days). Although the DNA-bound platinum adduct were higher at 4 h after CED than 24 h for carboplatin group, combination with radiotherapy led to similar improvement of median survival time. However, less toxicity was observed in animals irradiated 24 h after CED-based chemotherapy. In conclusion, CED increased the accumulation of platinum drugs in tumor, reduced the toxicity, and resulted in a higher median survival time. The best treatment was obtained in animals treated with carboplatin and irradiated 24 h later. PMID:25784204

New configuration for efficient and durable copper coating on the outer surface of a tube

DOE PAGES

Ahmad, Irfan; Chapman, Steven F.; Velas, Katherine M.; ...

2017-03-27

A well-adhered copper coating on stainless steel power coupler parts is required in superconducting radio frequency (SRF) accelerators. Radio frequency power coupler parts are complex, tubelike stainless steel structures, which require copper coating on their outer and inner surfaces. Conventional copper electroplating sometimes produces films with inadequate adhesion strength for SRF applications. Electroplating also requires a thin nickel strike layer under the copper coating, whose magnetic properties can be detrimental to SRF applications. Coaxial energetic deposition (CED) and sputtering methods have demonstrated efficient conformal coating on the inner surfaces of tubes but coating the outer surface of a tube ismore » challenging because these coating methods are line of sight. When the substrate is off axis and the plasma source is on axis, only a small section of the substrate’s outer surface is exposed to the source cathode. The conventional approach is to rotate the tube to achieve uniformity across the outer surface. This method results in poor film thickness uniformity and wastes most of the source plasma. Alameda Applied Sciences Corporation (AASC) has developed a novel configuration called hollow external cathode CED (HEC-CED) to overcome these issues. HEC-CED produces a film with uniform thickness and efficiently uses all eroded source material. Furthermore, the Cu film deposited on the outside of a stainless steel tube using the new HEC-CED configuration survived a high pressure water rinse adhesion test. HEC-CED can be used to coat the outside of any cylindrical structure.« less

Convection-enhancement delivery of platinum-based drugs and Lipoplatin(TM) to optimize the concomitant effect with radiotherapy in F98 glioma rat model.

PubMed

Shi, Minghan; Fortin, David; Sanche, Léon; Paquette, Benoit

2015-06-01

The prognosis for patients with glioblastoma remains poor with current treatments. Although platinum-based drugs are sometimes offered at relapse, their efficacy in this setting is still disputed. In this study, we use convection-enhanced delivery (CED) to deliver the platinum-based drugs (cisplatin, carboplatin, and Lipoplatin(TM) - liposomal formulation of cisplatin) directly into the tumor of F98 glioma-bearing rats that were subsequently treated with γ radiation (15 Gy). CED increased by factors varying between 17 and 111, the concentration of these platinum-based drugs in the brain tumor compared to intra-venous (i.v.) administration, and by 9- to 34-fold, when compared to intra-arterial (i.a.) administration. Furthermore, CED resulted in a better systemic tolerance to platinum drugs compared to their i.a. injection. Among the drugs tested, carboplatin showed the highest maximum tolerated dose (MTD). Treatment with carboplatin resulted in the best median survival time (MeST) (38.5 days), which was further increased by the addition of radiotherapy (54.0 days). Although the DNA-bound platinum adduct were higher at 4 h after CED than 24 h for carboplatin group, combination with radiotherapy led to similar improvement of median survival time. However, less toxicity was observed in animals irradiated 24 h after CED-based chemotherapy. In conclusion, CED increased the accumulation of platinum drugs in tumor, reduced the toxicity, and resulted in a higher median survival time. The best treatment was obtained in animals treated with carboplatin and irradiated 24 h later.

New configuration for efficient and durable copper coating on the outer surface of a tube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmad, Irfan; Chapman, Steven F.; Velas, Katherine M.

A well-adhered copper coating on stainless steel power coupler parts is required in superconducting radio frequency (SRF) accelerators. Radio frequency power coupler parts are complex, tubelike stainless steel structures, which require copper coating on their outer and inner surfaces. Conventional copper electroplating sometimes produces films with inadequate adhesion strength for SRF applications. Electroplating also requires a thin nickel strike layer under the copper coating, whose magnetic properties can be detrimental to SRF applications. Coaxial energetic deposition (CED) and sputtering methods have demonstrated efficient conformal coating on the inner surfaces of tubes but coating the outer surface of a tube ismore » challenging because these coating methods are line of sight. When the substrate is off axis and the plasma source is on axis, only a small section of the substrate’s outer surface is exposed to the source cathode. The conventional approach is to rotate the tube to achieve uniformity across the outer surface. This method results in poor film thickness uniformity and wastes most of the source plasma. Alameda Applied Sciences Corporation (AASC) has developed a novel configuration called hollow external cathode CED (HEC-CED) to overcome these issues. HEC-CED produces a film with uniform thickness and efficiently uses all eroded source material. Furthermore, the Cu film deposited on the outside of a stainless steel tube using the new HEC-CED configuration survived a high pressure water rinse adhesion test. HEC-CED can be used to coat the outside of any cylindrical structure.« less

ISO Mid-Infrared Spectra of Reflection Nebulae

NASA Technical Reports Server (NTRS)

Werner, M.; Uchida, K.; Sellgren, K.; Houdashelt, M.

1999-01-01

Our goal is to test predictions of models attributing the IEFs to polycyclic aromatic hydrocarbons (PAHs). Interstellar models predict PAHs change from singly ionized to neutral as the UV intensity, Go, decreases.

Interpretation of a Variable Reflection Nebula Associated with HBC 340 and HBC 341 in NGC 1333

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dahm, S. E.; Hillenbrand, L. A.

We present multi-epoch, R -band imaging obtained from the Palomar Transient Factory of a small, fan-shaped reflection nebula in NGC 1333 that experiences prominent brightness fluctuations. Photometry of HBC 340 (K7e) and HBC 341 (M5e), a visual pair of late-type, young stellar objects lying near the apex of the nebula, demonstrates that while both are variable, the former has brightened by more than two magnitudes following a deep local minimum in 2014 September. Keck high-dispersion ( R  ∼ 45,000–66,000), optical spectroscopy of HBC 340 suggests that the protostar is a spectroscopic binary (HBC 340Aa + HBC 340Ab). Both HBC 340 andmore » HBC 341 exhibit strong H α and forbidden line emission, consistent with accretion and outflow. We conclude that the brightness fluctuations in the reflection nebula represent light echos produced by varying incident radiation emanating from HBC 340. The short-term variability observed in the protostar is attributed to irregular accretion activity, while correlated, dipping behavior on a several hundred day timescale may be due to eclipse-like events caused by orbiting circumstellar material. Archival Hubble Space Telescope imaging of the region reveals a second, faint (F814W ∼ 20.3 mag) companion to HBC 340 that lies 1.″02 (∼235 au) east of the protostar. If associated, this probable substellar mass object (20–50 Jupiter masses), HBC 340B, is likely unrelated to the observed brightness variations. The sustained brightening of HBC 340 since late 2014 can be explained by an EXor-like outburst, the recovery from a long duration eclipse event caused by obscuring circumstellar dust, or by the gradual removal of extincting material from along the line of sight. Our analysis here favors one of the extinction scenarios.« less

75 FR 52007 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

...) Community Economic Development (CED) and Job Opportunities for Low-Income Individuals (JOLI) Standard... key information about projects funded through the Community Economic Development (CED) and Job... previously approved questionnaire, Office of Management and Budget (OMB) Control Number: 0970-0317. Questions...

Antenatal and postnatal psychopathology among women with current and past eating disorders: longitudinal patterns.

PubMed

Easter, Abigail; Solmi, Francessca; Bye, Amanda; Taborelli, Emma; Corfield, Freya; Schmidt, Ulrike; Treasure, Janet; Micali, Nadia

2015-01-01

This study aims to investigate longitudinal patterns of psychopathology during the antenatal and postnatal periods among women with current (C-ED) and past (P-ED) eating disorders. Women were recruited to a prospective longitudinal study: C-ED (n = 31), P-ED (n = 29) and healthy control (HC; n = 57). Anxiety, depression and ED symptoms were measured at four time points: first/second trimester, third trimester, 8 weeks and 6 months postpartum. Linear mixed effects models were used to test for group differences. Women with C-ED and P-ED, in all diagnostic categories, had significantly higher levels of psychopathology at all time points. ED symptoms decreased in the C-ED group, compared with an overall increase in the other two groups but subsequently increased after pregnancy. Overall, depression and state and trait anxiety scores decreased in the C-ED group compared with the HC group throughout the antenatal and postnatal periods. High levels of psychopathology are common throughout the antenatal and postnatal periods among women with current and past ED, and despite some overall reductions, symptoms remain clinically significant. © 2014 The Authors. European Eating Disorders Review published by John Wiley & Sons, Ltd. © 2014 The Authors. European Eating Disorders Review published by John Wiley & Sons, Ltd.

Convection-enhanced delivery for the treatment of glioblastoma.

PubMed

Vogelbaum, Michael A; Aghi, Manish K

2015-03-01

Effective treatment of glioblastoma (GBM) remains a formidable challenge. Survival rates remain poor despite decades of clinical trials of conventional and novel, biologically targeted therapeutics. There is considerable evidence that most of these therapeutics do not reach their targets in the brain when administered via conventional routes (intravenous or oral). Hence, direct delivery of therapeutics to the brain and to brain tumors is an active area of investigation. One of these techniques, convection-enhanced delivery (CED), involves the implantation of catheters through which conventional and novel therapeutic formulations can be delivered using continuous, low-positive-pressure bulk flow. Investigation in preclinical and clinical settings has demonstrated that CED can produce effective delivery of therapeutics to substantial volumes of brain and brain tumor. However, limitations in catheter technology and imaging of delivery have prevented this technique from being reliable and reproducible, and the only completed phase III study in GBM did not show a survival benefit for patients treated with an investigational therapeutic delivered via CED. Further development of CED is ongoing, with novel catheter designs and imaging approaches that may allow CED to become a more effective therapeutic delivery technique. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Special funding schemes for innovative medical devices in French hospitals: the pros and cons of two different approaches.

PubMed

Martelli, Nicolas; van den Brink, Hélène

2014-07-01

Financing innovative medical devices is an important challenge for national health policy makers, and a crucial issue for hospitals. However, when innovative medical devices are launched on the European market there is generally little clinical evidence regarding both efficacy and safety, both because of the flaws in the European system for regulating such devices, and because they are at an early stage of development. To manage the uncertainty surrounding the reimbursement of innovation, several European countries have set up temporary funding schemes to generate evidence about the effectiveness of devices. This article explores two different French approaches to funding innovative in-hospital devices and collecting supplementary data: the coverage with evidence development (CED) scheme introduced under Article L. 165-1-1 of the French Social Security Code; and national programs for hospital-based research. We discuss pros and cons of both approaches in the light of CED policies in Germany and the UK. The CED policies for devices share common limitations. Thus, transparency of CED processes should be enhanced and decisions need to be made in a timely way. Finally, we think that closer collaboration between manufacturers, health authorities and hospitals is essential to make CED policies more operational. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

NCSP IER 422 CED-3b Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hutchinson, Jesson D.; Cutler, Theresa Elizabeth; Bahran, Rian Mustafa

2017-11-22

A Subcritical Copper-Reflected α-phase Plutonium (SCRαP) integral benchmark experiment has been designed and measured. In this experiment, multiplication is approximated using correlated neutron data from a detector system consisting of 3He tubes inside high density polyethylene (HDPE). Measurements were performed on various subcritical experimental configurations consisting of a weapons-grade plutonium sphere surrounded by different Cu thicknesses. In addition to the proposed base experimental configurations with Cu, additional configurations were performed with the plutonium ball nested in various thicknesses of interleaved HDPE spherical shells mixed in with the Cu shells. The HDPE is intended to provide fast neutron moderation and reflection,more » resulting in additional measurements with differing multiplication, spectra, and nuclear data sensitivity.« less

Spatial Variation of the 3.29 and 3.40 Micron Emission Bands Within Reflection Nebulae and The Photochemical Evolution of Methylated Polycyclic Aromatic Hydrocarbons

NASA Technical Reports Server (NTRS)

Joblin, C.; Tielens, A. G. G. M.; Allamandola, L. J.; Geballe, T. R.

1996-01-01

Spectra of 3 microns emission features have been obtained at several positions within the reflection nebulae NGC 1333 SVS3 and NGC 2023. Strong variations of the relative intensities of the 3.29 microns feature and its most prominent satellite band at 3.40 microns are found. It is shown that: (1) the 3.40 microns band is too intense with respect to the 3.29 microns band at certain positions to arise from hot band emission alone, (2) the 3.40 microns band can be reasonably well matched by new laboratory spectra of gas-phase polycyclic aromatic hydrocarbons (PAHs) with alkyl (-CH3) side groups, and (3) the variations in the 3.40 microns to 3.29 microns band intensity ratios are consistent with the photochemical erosion of alkylated PAHs. We conclude that the 3.40 microns emission feature is attributable to -CH3 side groups on PAH molecules. We predict a value of 0.5 for the peak intensity ratio of the 3.40 and 3.29 microns emission bands from free PAHs in the diffuse interstellar medium, which would correspond to a proportion of one methyl group for four peripheral hydrogens. We also compare the 3 microns spectrum of the proto-planetary nebula IRAS 05341 + 0852 with the spectrum of the planetary nebula IRAS 21282 + 5050. We suggest that a photochemical evolution of the initial aliphatic and aromatic hydrocarbon mixture formed in the outflow is responsible for the changes observed in the 3 microns emission spectra of these objects.

Spatial variation of the 3.29 and 3.40 micron emission bands within reflection nebulae and the photochemical evolution of methylated polycyclic aromatic hydrocarbons

NASA Technical Reports Server (NTRS)

Joblin, C.; Tielens, A. G.; Allamandola, L. J.; Geballe, T. R.

1996-01-01

Spectra of 3 micrometers emission features have been obtained at several positions within the reflection nebulae NGC 1333 SVS3 and NGC 2023. Strong variations of the relative intensities of the 3.29 micrometers feature and its most prominent satellite band at 3.40 micrometers are found. It is shown that (i) the 3.40 micrometers band is too intense with respect to the 3.29 micrometers band at certain positions to arise from hot band emission alone, (ii) the 3.40 micrometers band can be reasonably well matched by new laboratory spectra of gas-phase polycyclic aromatic hydrocarbons (PAHs) with alkyl (-CH3) side groups, and (iii) the variations in the 3.40 micrometers to 3.29 micrometers band intensity ratios are consistent with the photochemical erosion of alkylated PAHs. We conclude that the 3.40 micrometers emission feature is attributable to -CH3 side groups on PAH molecules. We predict a value of 0.5 for the peak intensity ratio of the 3.40 and 3.29 micrometers emission bands from free PAHs in the diffuse interstellar medium, which would correspond to a proportion of one methyl group for four peripheral hydrogens. We also compare the 3 micrometers spectrum of the proto-planetary nebula IRAS 05341+0852 with the spectrum of the planetary nebula IRAS 21282+5050. We suggest that a photochemical evolution of the initial aliphatic and aromatic hydrocarbon mixture formed in the outflow is responsible for the changes observed in the 3 micrometers emission spectra of these objects.

77 FR 38580 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... CEDS planning process and resulting CEDS is designed to guide the economic growth of an area and...: Economic Development Administration (EDA). Title: Comprehensive Economic Development Strategies. OMB... and Economic Adjustment programs, applicants must undertake a planning process that results in a...

The Core Molecular Machinery Used for Engulfment of Apoptotic Cells Regulates the JNK Pathway Mediating Axon Regeneration in Caenorhabditis elegans.

PubMed

Pastuhov, Strahil Iv; Fujiki, Kota; Tsuge, Anna; Asai, Kazuma; Ishikawa, Sho; Hirose, Kazuya; Matsumoto, Kunihiro; Hisamoto, Naoki

2016-09-14

The mechanisms that govern the ability of specific neurons to regenerate their axons after injury are not well understood. In Caenorhabditis elegans, the initiation of axon regeneration is positively regulated by the JNK-MAPK pathway. In this study, we identify two components functioning upstream of the JNK pathway: the Ste20-related protein kinase MAX-2 and the Rac-type GTPase CED-10. CED-10, when bound by GTP, interacts with MAX-2 and functions as its upstream regulator in axon regeneration. CED-10, in turn, is activated by axon injury via signals initiated from the integrin α-subunit INA-1 and the nonreceptor tyrosine kinase SRC-1 and transmitted via the signaling module CED-2/CrkII-CED-5/Dock180-CED-12/ELMO. This module is also known to regulate the engulfment of apoptotic cells during development. Our findings thus reveal that the molecular machinery used for engulfment of apoptotic cells also promotes axon regeneration through activation of the JNK pathway. The molecular mechanisms of axon regeneration after injury remain poorly understood. In Caenorhabditis elegans, the initiation of axon regeneration is positively regulated by the JNK-MAPK pathway. In this study, we show that integrin, Rac-GTPase, and several other molecules, all of which are known to regulate engulfment of apoptotic cells during development, also regulate axon regeneration. This signaling module activates the JNK-MAPK cascade via MAX-2, a PAK-like protein kinase that binds Rac. Our findings thus reveal that the molecular machinery used for engulfment of apoptotic cells also promotes axon regeneration through activation of the JNK pathway. Copyright © 2016 the authors 0270-6474/16/369710-12$15.00/0.

Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model.

PubMed

Singleton, W G; Collins, A M; Bienemann, A S; Killick-Cole, C L; Haynes, H R; Asby, D J; Butts, C P; Wyatt, M J; Barua, N U; Gill, S S

2017-01-01

The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood-brain barrier when administered systemically. In this article, we describe the in vitro and in vivo efficacy of a novel water-soluble nano-micellar formulation of panobinostat designed for administration by convection enhanced delivery (CED). The in vitro efficacy of panobinostat-loaded nano-micelles against rat F98, human U87-MG and M059K glioma cells and against patient-derived glioma stem cells was measured using a cell viability assay. Nano-micelle distribution in rat brain was analyzed following acute CED using rhodamine-labeled nano-micelles, and toxicity was assayed using immunofluorescent microscopy and synaptophysin enzyme-linked immunosorbent assay. We compared the survival of the bioluminescent syngenic F98/Fischer344 rat glioblastoma model treated by acute CED of panobinostat-loaded nano-micelles with that of untreated and vehicle-only-treated controls. Nano-micellar panobinostat is cytotoxic to rat and human glioma cells in vitro in a dose-dependent manner following short-time exposure to drug. Fluorescent rhodamine-labelled nano-micelles distribute with a volume of infusion/volume of distribution (Vi/Vd) ratio of four and five respectively after administration by CED. Administration was not associated with any toxicity when compared to controls. CED of panobinostat-loaded nano-micelles was associated with significantly improved survival when compared to controls (n=8 per group; log-rank test, P <0.001). One hundred percent of treated animals survived the 60-day experimental period and had tumour response on post-mortem histological examination. CED of nano-micellar panobinostat represents a potential novel therapeutic option for malignant glioma and warrants translation into the clinic.

A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma.

PubMed

Barua, Neil U; Hopkins, Kirsten; Woolley, Max; O'Sullivan, Stephen; Harrison, Rob; Edwards, Richard J; Bienemann, Alison S; Wyatt, Marcella J; Arshad, Azeem; Gill, Steven S

2016-01-01

Inadequate penetration of the blood-brain barrier (BBB) by systemically administered chemotherapies including carboplatin is implicated in their failure to improve prognosis for patients with glioblastoma. Convection-enhanced delivery (CED) of carboplatin has the potential to improve outcomes by facilitating bypass of the BBB. We report the first use of an implantable CED system incorporating a novel transcutaneous bone-anchored port (TBAP) for intermittent CED of carboplatin in a patient with recurrent glioblastoma. The CED catheter system was implanted using a robot-assisted surgical method. Catheter targeting accuracy was verified by performing intra-operative O-arm imaging. The TBAP was implanted using a skin-flap dermatome technique modeled on bone-anchored hearing aid surgery. Repeated infusions were performed by attaching a needle administration set to the TBAP. Drug distribution was monitored with serial real-time T2-weighted magnetic resonance imaging (MRI). All catheters were implanted to within 1.5 mm of their planned target. Intermittent infusions of carboplatin were performed on three consecutive days and repeated after one month without the need for further surgical intervention. Infused volumes of 27.9 ml per day were well tolerated, with the exception of a single seizure episode. Follow-up MRI at eight weeks demonstrated a significant reduction in the volume of tumor enhancement from 42.6 ml to 24.6 ml, and was associated with stability of the patient's clinical condition. Reduction in the volume of tumor enhancement indicates that intermittent CED of carboplatin has the potential to improve outcomes in glioblastoma. The novel technology described in this report make intermittent CED infusion regimes an achievable treatment strategy.

Application of Factor Analysis to Identify Dietary Patterns and Use of Factor Scores to Study Their Relationship with Nutritional Status of Adult Rural Populations

PubMed Central

Brahmam, G.N.V.; Vijayaraghavan, K.

2011-01-01

The prevalence of chronic energy deficiency (CED) among one-third of the Indian population is attributed to inadequacy of consumption of nutrients. However, considering the complexity of diets among Indians, the relationship between a particular dietary pattern and the nutritional status of the population has not been established so far. A community-based cross-sectional study was undertaken to assess estimates, at district level, of diet and nutritional status in Orissa State, India. Factor analysis was used for exploring the existence of consumption pattern of food and nutrients and their relationship with the nutritional status of rural adult population. Data on 2,864 adult men and 3,525 adult women in Orissa state revealed that there exists six patterns among food-groups explaining 59% of the total variation and three patterns among nutrients that explain 73% of the total variation among both adult men and women. The discriminant function analysis revealed that, overall, 53% of the men were correctly classified as either with chronic energy deficiency (CED) or without CED. Similarly, overall, 54% of the women were correctly classified as either with CED or without CED. The sensitivity of the model was 65% for both men and women, and the specificity was 46% and 41% respectively for men and women. In the case of classification of overweight/obesity, the prediction of the model was about 75% among both men and women, along with high sensitivity. Using factor analysis, the dietary patterns were identified from the food and nutrient intake data. There exists a strong relationship between the dietary patterns and the nutritional status of rural adults. These results will help identify the community people with CED and help planners formulate nutritional interventions accordingly. PMID:21957671

Isatis indigotica induces hepatocellular cancer cell death via caspase-independent apoptosis-inducing factor translocation apoptotic pathway in vitro and in vivo.

PubMed

Chung, Ying-Cheng; Tang, Feng-Yao; Liao, Jiunn-Wang; Chung, Chia-Hua; Jong, Ting-Ting; Chen, Shih-Shiung; Tsai, Ching-Hsiu; Chiang, En-Pei

2011-06-01

Isatis indigotica is a biennial herbaceous cruciferous medical herb with antipyretic, antiviral, anti-inflammatory, and anti-endotoxin activity. This study explored the chemotherapeutic potential of I indigotica on human hepatoma cells and investigated the mechanism by which metabolites from I indigotica inhibit hepatoma cell growth. Antitumor activity was discovered in dried I indigotica leaf chloroform extracts (CEDLI). In nude mice xenotransplanted with human hepatoma cells, CEDLI supplementation inhibited tumor growth by ~40% compared with nonsupplemented animals without affecting body weight/food intake. CEDLI induced sub-G1 cell cycle arrest and apoptosis in hepatoma cells. Furthermore, CEDLI activates p53 and Bax, reduces Bcl-2 expression, and causes mitochondrial stress and the release of apoptosis-inducing factor into the cytosol followed by its translocation into the nucleus, resulting in hepatoma cell apoptosis. This study provides novel in vivo evidence of I indigotica's antitumor activity. The chemotherapeutic activity against human hepatoma tumorigenesis was because of a distinguished caspase-independent apoptotic pathway.

The effect of less-lethal weapons on injuries in police use-of-force events.

PubMed

MacDonald, John M; Kaminski, Robert J; Smith, Michael R

2009-12-01

We investigated the effect of the use of less-lethal weapons, conductive energy devices (CEDs), and oleoresin capsicum (OC) spray on the prevalence and incidence of injuries to police officers and civilians in encounters involving the use of force. We analyzed data from 12 police departments that documented injuries to officers and civilians in 24,380 cases. We examined monthly injury rates for 2 police departments before and after their adoption of CEDs. Odds of injury to civilians and officers were significantly lower when police used CED weapons, after control for differences in case attributes and departmental policies restricting use of these weapons. Monthly incidence of injury in 2 police departments declined significantly, by 25% to 62%, after adoption of CED devices. Injuries sustained during police use-of-force events affect thousands of police officers and civilians in the United States each year. Incidence of these injuries can be reduced dramatically when law enforcement agencies responsibly employ less-lethal weapons in lieu of physical force.

The Integration of Emotions in Memories: Cognitive-Emotional Distinctiveness and Posttraumatic Stress Disorder

PubMed Central

Boals, Adriel; Rubin, David C.

2013-01-01

The current study examined cognitive-emotional distinctiveness (CED), the extent to which emotions are linked with event information, in memories associated with PTSD. Participants either with PTSD (n=68) or without PTSD (n=40) completed a modified multidimensional scaling technique to measure CED for their most negative and most positive events. The results revealed that participants in the PTSD group evidenced significantly lower levels of CED. This group difference remained significant when we limited the analysis to traumatic events that led to a PTSD diagnosis (n=33) in comparison to control participants who nominated a traumatic event that did not result in PTSD (n=32). Replicating previous findings, CED levels were higher in memories of negative events, in comparison to positive events. These results provide empirical evidence that memories associated with PTSD do contain special organizational features with respect to the links between emotions and memory. Implications for understanding and treating PTSD are discussed. PMID:23436960

Convection-Enhanced Delivery.

PubMed

Mehta, A M; Sonabend, A M; Bruce, J N

2017-04-01

Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system. It addresses and offers solutions to many limitations of conventional techniques, allowing for delivery past the blood-brain barrier in a targeted and safe manner that can achieve therapeutic drug concentrations. CED is a broadly applicable technique that can be used to deliver a variety of therapeutic compounds for a diversity of diseases, including malignant gliomas, Parkinson's disease, and Alzheimer's disease. While a number of technological advances have been made since its development in the early 1990s, clinical trials with CED have been largely unsuccessful, and have illuminated a number of parameters that still need to be addressed for successful clinical application. This review addresses the physical principles behind CED, limitations in the technique, as well as means to overcome these limitations, clinical trials that have been performed, and future developments.

Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.

PubMed

Yang, Weilian; Huo, Tianyao; Barth, Rolf F; Gupta, Nilendu; Weldon, Michael; Grecula, John C; Ross, Brian D; Hoff, Benjamin A; Chou, Ting-Chao; Rousseau, Julia; Elleaume, Hélène

2011-02-01

The purpose of this study was to further evaluate the therapeutic efficacy of convection enhanced delivery (CED) of carboplatin in combination with radiotherapy for treatment of the F98 rat glioma. Tumor cells were implanted stereotactically into the brains of syngeneic Fischer rats, and 13 or 17 d. later carboplatin (20 μg/10 μl) was administered by either CED over 30 min or by Alzet osmotic pumps (0.5 μg/μl/h for 168 h.) beginning at 7 d after tumor implantation. Rats were irradiated with a 15 Gy fractionated dose (5 Gy × 3) of 6 MV photons to the whole brain beginning on the day after drug administration. Other groups of rats received either carboplatin or X-irradiation alone. The tumor carboplatin concentration following CED of 20 μg in 10 μl was 10.4 μg/g, which was equal to that observed following i.v. administration of 100 mg/kg b.w. Rats bearing small tumors, treated with carboplatin and X-irradiation, had a mean survival time (MST) of 83.4 d following CED and 111.8 d following pump delivery with 40% of the latter surviving >180 d (i.e. cured) compared to 55.2 d for CED and 77.2 d. for pump delivery of carboplatin alone and 31.8 d and 24.2 d, respectively, for X-irradiated and untreated controls. There was no microscopic evidence of residual tumor in the brains of all long-term survivors. Not surprisingly, rats with large tumors had much shorter MSTs. Only modest increases in MSTs were observed in animals that received either oral administration or CED of temozolomide plus X-irradiation (23.2 d and 29.3 d) compared to X-irradiation alone. The present survival data, and those previously reported by us, are among the best ever obtained with the F98 glioma model. Initially, they could provide a platform for a Phase I clinical trial to evaluate the safety and potential therapeutic efficacy of CED of carboplatin in patients with recurrent glioblastomas, and ultimately a Phase II trial of carboplatin in combination with radiation therapy.

The Importance of Being a Complement: CED Effects Revisited

ERIC Educational Resources Information Center

Jurka, Johannes

2010-01-01

This dissertation revisits subject island effects (Ross 1967, Chomsky 1973) cross-linguistically. Controlled acceptability judgment studies in German, English, Japanese and Serbian show that extraction out of specifiers is consistently degraded compared to extraction out of complements, indicating that the Condition on Extraction domains (CED,…

7 CFR 1220.623 - Canvassing requests.

Code of Federal Regulations, 2010 CFR

2010-01-01

... designate the County Executive Director (CED) and a county or State FSA office employee to canvass the... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.623 Canvassing requests. (a... for this function is impractical, and designate the CED and/or another county or State FSA office...

7 CFR 1220.623 - Canvassing requests.

Code of Federal Regulations, 2013 CFR

2013-01-01

... designate the County Executive Director (CED) and a county or State FSA office employee to canvass the... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.623 Canvassing requests. (a... for this function is impractical, and designate the CED and/or another county or State FSA office...

7 CFR 1220.623 - Canvassing requests.

Code of Federal Regulations, 2012 CFR

2012-01-01

... designate the County Executive Director (CED) and a county or State FSA office employee to canvass the... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.623 Canvassing requests. (a... for this function is impractical, and designate the CED and/or another county or State FSA office...

7 CFR 1220.623 - Canvassing requests.

Code of Federal Regulations, 2014 CFR

2014-01-01

... designate the County Executive Director (CED) and a county or State FSA office employee to canvass the... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.623 Canvassing requests. (a... for this function is impractical, and designate the CED and/or another county or State FSA office...

75 FR 81614 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... (CED) and Job Opportunities for Low-Income Individuals (JOLI) Standard Reporting Format. OMB No.: New... funded through the Community Economic Development (CED) and Job Opportunities for Low-Income Individuals... Report (PPR) is a new proposed reporting format that will collect information concerning the outcomes and...

7 CFR 1220.623 - Canvassing requests.

Code of Federal Regulations, 2011 CFR

2011-01-01

... designate the County Executive Director (CED) and a county or State FSA office employee to canvass the... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.623 Canvassing requests. (a... for this function is impractical, and designate the CED and/or another county or State FSA office...

Clinical and molecular characterization of 40 patients with classic Ehlers–Danlos syndrome: identification of 18 COL5A1 and 2 COL5A2 novel mutations

PubMed Central

2013-01-01

Background Classic Ehlers–Danlos syndrome (cEDS) is a rare autosomal dominant connective tissue disorder that is primarily characterized by skin hyperextensibility, abnormal wound healing/atrophic scars, and joint hypermobility. A recent study demonstrated that more than 90% of patients who satisfy all of these major criteria harbor a type V collagen (COLLV) defect. Methods This cohort included 40 patients with cEDS who were clinically diagnosed according to the Villefranche nosology. The flowchart that was adopted for mutation detection consisted of sequencing the COL5A1 gene and, if no mutation was detected, COL5A2 analysis. In the negative patients the presence of large genomic rearrangements in COL5A1 was investigated using MLPA, and positive results were confirmed via SNP-array analysis. Results We report the clinical and molecular characterization of 40 patients from 28 families, consisting of 14 pediatric patients and 26 adults. A family history of cEDS was present in 9 patients. The majority of the patients fulfilled all the major diagnostic criteria for cEDS; atrophic scars were absent in 2 females, skin hyperextensibility was not detected in a male and joint hypermobility was negative in 8 patients (20% of the entire cohort). Wide inter- and intra-familial phenotypic heterogeneity was observed. We identified causal mutations with a detection rate of approximately 93%. In 25/28 probands, COL5A1 or COL5A2 mutations were detected. Twenty-one mutations were in the COL5A1 gene, 18 of which were novel (2 recurrent). Of these, 16 mutations led to nonsense-mediated mRNA decay (NMD) and to COLLV haploinsufficiency and 5 mutations were structural. Two novel COL5A2 splice mutations were detected in patients with the most severe phenotypes. The known p. (Arg312Cys) mutation in the COL1A1 gene was identified in one patient with vascular-like cEDS. Conclusions Our findings highlight that the three major criteria for cEDS are useful and sufficient for cEDS clinical diagnosis in the large majority of the patients. The borderline patients for whom these criteria fail can be diagnosed when minor signs of connective tissue diseases and family history are present and when genetic testing reveals a defect in COLLV. Our data also confirm that COL5A1 and COL5A2 are the major, if not the only, genes involved in cEDS. PMID:23587214

Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts1

PubMed Central

Yamashita, Yoji; Krauze, Michal T.; Kawaguchi, Tomohiro; Noble, Charles O.; Drummond, Daryl C.; Park, John W.; Bankiewicz, Krystof S.

2007-01-01

Despite multimodal treatment options, the response and survival rates for patients with malignant gliomas remain dismal. Clinical trials with convection-enhanced delivery (CED) have recently opened a new window in neuro-oncology to the direct delivery of chemotherapeutics to the CNS, circumventing the blood-brain barrier and reducing systemic side effects. Our previous CED studies with liposomal chemotherapeutics have shown promising antitumor activity in rodent brain tumor models. In this study, we evaluated a combination of nanoliposomal topotecan (nLs-TPT) and pegylated liposomal doxorubicin (PLD) to enhance efficacy in our brain tumor models, and to establish a CED treatment capable of improving survival from malignant brain tumors. Both liposomal drugs decreased key enzymes involved in tumor cell replication in vitro. Synergistic effects of nLs-TPT and PLD on U87MG cell death were found. The combination displayed excellent efficacy in a CED-based survival study 10 days after tumor cell implantation. Animals in the control group and those in single-agent groups had a median survival of less than 30 days, whereas the combination group experienced a median survival of more than 90 days. We conclude that CED of two liposomal chemotherapeutics (nLs-TPT and PLD) may be an effective treatment option for malignant gliomas. PMID:17018695

Resolving the Circumstellar Environment of the Galactic B[e] Supergiant Star MWC 137 from Large to Small Scales

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraus, Michaela; Nickeler, Dieter H.; Liimets, Tiina

The Galactic object MWC 137 has been suggested to belong to the group of B[e] supergiants. However, with its large-scale optical bipolar ring nebula and high-velocity jet and knots, it is a rather atypical representative of this class. We performed multiwavelength observations spreading from the optical to the radio regimes. Based on optical imaging and long-slit spectroscopic data, we found that the northern parts of the large-scale nebula are predominantly blueshifted, while the southern regions appear mostly redshifted. We developed a geometrical model consisting of two double cones. Although various observational features can be approximated with such a scenario, themore » observed velocity pattern is more complex. Using near-infrared integral-field unit spectroscopy, we studied the hot molecular gas in the vicinity of the star. The emission from the hot CO gas arises in a small-scale disk revolving around the star on Keplerian orbits. Although the disk itself cannot be spatially resolved, its emission is reflected by the dust arranged in arc-like structures and the clumps surrounding MWC 137 on small scales. In the radio regime, we mapped the cold molecular gas in the outskirts of the optical nebula. We found that large amounts of cool molecular gas and warm dust embrace the optical nebula in the east, south, and west. No cold gas or dust was detected in the north and northwestern regions. Despite the new insights into the nebula kinematics gained from our studies, the real formation scenario of the large-scale nebula remains an open issue.« less

Dust in Extragalactic Reflection Nebulae

NASA Astrophysics Data System (ADS)

Lee, Chris H.; Hodges-Kluck, Edmund J.

2017-08-01

Observational evidence for extragalactic dust has been recently found in the form of UV extragalactic reflection nebulae around edge-on spiral galaxies, but the nature of the dust is largely unknown. To derive dust parameters, UV fluxes from the spacecrafts GALEX and Swift have been compared with model UV halo SEDs, which have been created from galaxy template spectra and a silicate-graphite dust model. The model contains two free parameters, which are fractional composition and maximum grain size. These analyses have been done for a sample of 8 nearby edge-on spiral galaxies with bright UV halos, where the dust properties can be spatially resolved, such as inside and outside of galactic winds or as a function of height from the galactic disc. The dust properties give insight into how dust is expelled from the galactic disc, which can also be applied to understanding gaseous outflows from the galaxies as well.

LSS 2018: A double-lined spectroscopic binary central star with an extremely large reflection effect

NASA Technical Reports Server (NTRS)

Drilling, J. S.

1985-01-01

LSS 2018, the central star of the planetry nebulae DS1, was found to be a double-lined spectroscopic binary with a period of 8.571 hours. Light variations with the same period were observed in U, B, and V; in the wavelength regions defined by the two IUE cameras; and in the strength of the CIII 4647 emission line. The light variations can be accurately predicted by a simple reflection effect, and an analysis of the light curves yields the angular diameter and effective temperature of the primary, the radii of the two stars in terms of their separation, and the inclination of the system. Analysis of the radial velocities then yields the masses of the two stars, their separation, the distance of the system, the absolute magnitude of the primary, and the size of the nebula.

7 CFR 1221.227 - Canvassing voting ballots.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Director (CED) and a county or State FSA office employee to canvass the ballots and report the results... INFORMATION ORDER Procedures for the Conduct of Referenda Procedures § 1221.227 Canvassing voting ballots. (a..., and designate the CED and/or another county or State FSA office employee to canvass requests in any...

7 CFR 1221.227 - Canvassing voting ballots.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Director (CED) and a county or State FSA office employee to canvass the ballots and report the results... INFORMATION ORDER Procedures for the Conduct of Referenda Procedures § 1221.227 Canvassing voting ballots. (a..., and designate the CED and/or another county or State FSA office employee to canvass requests in any...

7 CFR 1221.227 - Canvassing voting ballots.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Director (CED) and a county or State FSA office employee to canvass the ballots and report the results... INFORMATION ORDER Procedures for the Conduct of Referenda Procedures § 1221.227 Canvassing voting ballots. (a..., and designate the CED and/or another county or State FSA office employee to canvass requests in any...

7 CFR 1280.627 - Canvassing voting ballots.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Executive Director (CED) and a county or State FSA office employee to canvass the ballots and report the... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.627 Canvassing voting ballots. (a... impractical, and designate the CED and/or another county or State FSA office employee to canvass requests in...

7 CFR 1280.627 - Canvassing voting ballots.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Executive Director (CED) and a county or State FSA office employee to canvass the ballots and report the... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.627 Canvassing voting ballots. (a... impractical, and designate the CED and/or another county or State FSA office employee to canvass requests in...

7 CFR 1280.627 - Canvassing voting ballots.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Executive Director (CED) and a county or State FSA office employee to canvass the ballots and report the... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.627 Canvassing voting ballots. (a... impractical, and designate the CED and/or another county or State FSA office employee to canvass requests in...

7 CFR 1221.227 - Canvassing voting ballots.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Director (CED) and a county or State FSA office employee to canvass the ballots and report the results... INFORMATION ORDER Procedures for the Conduct of Referenda Procedures § 1221.227 Canvassing voting ballots. (a..., and designate the CED and/or another county or State FSA office employee to canvass requests in any...

7 CFR 1280.627 - Canvassing voting ballots.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Executive Director (CED) and a county or State FSA office employee to canvass the ballots and report the... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.627 Canvassing voting ballots. (a... impractical, and designate the CED and/or another county or State FSA office employee to canvass requests in...

7 CFR 1280.627 - Canvassing voting ballots.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Executive Director (CED) and a county or State FSA office employee to canvass the ballots and report the... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.627 Canvassing voting ballots. (a... impractical, and designate the CED and/or another county or State FSA office employee to canvass requests in...

The carbon budget in the outer solar nebula.

PubMed

Simonelli, D P; Pollack, J B; McKay, C P; Reynolds, R T; Summers, A L

1989-01-01

Detailed models of the internal structures of Pluto and Charon, assuming rock and water ice as the only constituents, indicate that the mean silicate mass fraction of this two-body system is on the order of 0.7; thus the Pluto/Charon system is significantly "rockier" than the satellites of the giant planets (silicate mass fraction approximately 0.55). This compositional contrast reflects different formation mechanisms: it is likely that Pluto and Charon formed directly from the solar nebula, while the circumplanetary nebulae that produced the giant planet satellites were derived from envelopes that surrounded the forming giant planets (envelopes in which icy planetesimals dissolved more readily than rocky planetesimals). Simple cosmic abundance calculations, and the assumption that the Pluto/Charon system formed directly from solar nebula condensates, strongly suggest that the majority of the carbon in the outer solar nebula was in the form of carbon monoxide; these results are consistent with (1) inheritance from the dense molecular clouds in the interstellar medium (where CH4/CO < 10(-2) in the gas phase) and/or (2) of the Lewis and Prinn kinetic inhibition model of solar nebula chemistry. Theoretical predictions of the C/H enhancements in the atmospheres of the giant planets, when compared to the actual observed enhancements, suggest that 10%, or slightly more, of the carbon in the outer solar nebula was in the form of condensed materials (although the amount of condensed C may have dropped slightly with increasing heliocentric distance). Strict compositional limits computed for the Pluto/Charon system using the densities of CH4 and CO ices indicate that these pure ices are at best minor components in the interiors of these bodies, and imply that CH4 and CO ices were not the dominant C-bearing solids in the outer nebula. Clathrate-hydrates could not have appropriated enough CH4 or CO to be the major form of condensed carbon, although such clathrates may be necessary to explain the presence of methane on Pluto after its formation from a CO-rich nebula. Laboratory studies of carbonaceous chondrites, and spacecraft observations of Comet Halley, strongly suggest that of the remaining possibilities, organic material, rather than elemental carbon, is the most likely candidate for the dominant C-bearing solid in the outer solar nebula. We conclude that the majority of the carbon in the outer solar nebula was in gaseous CO; 10% to a few tens of percent of the C was in condensed organic materials; and at least a trace amount of carbon was in methane gas.

7 CFR 1220.629 - Disposition of records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... records will be placed in a secure location under the custody of the FSA CED for a period of not less than... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.629 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Request for Soybean...

7 CFR 1230.637 - Disposition of ballots and records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Disposition of ballots and records. (a) Producer ballots and records. Each FSA CED will place in sealed... summaries. Such records will be placed under lock in a safe place under the custody of the FSA CED for a..., South Agriculture Building, 1400 Independence Avenue, SW., Washington, DC. A Marketing Programs Branch...

7 CFR 1230.637 - Disposition of ballots and records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Disposition of ballots and records. (a) Producer ballots and records. Each FSA CED will place in sealed... summaries. Such records will be placed under lock in a safe place under the custody of the FSA CED for a..., South Agriculture Building, 1400 Independence Avenue, SW., Washington, DC. A Marketing Programs Branch...

7 CFR 1230.637 - Disposition of ballots and records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Disposition of ballots and records. (a) Producer ballots and records. Each FSA CED will place in sealed... summaries. Such records will be placed under lock in a safe place under the custody of the FSA CED for a..., South Agriculture Building, 1400 Independence Avenue, SW., Washington, DC. A Marketing Programs Branch...

7 CFR 1220.629 - Disposition of records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... records will be placed in a secure location under the custody of the FSA CED for a period of not less than... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.629 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Request for Soybean...

7 CFR 1220.629 - Disposition of records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... records will be placed in a secure location under the custody of the FSA CED for a period of not less than... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.629 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Request for Soybean...

7 CFR 1230.637 - Disposition of ballots and records.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Disposition of ballots and records. (a) Producer ballots and records. Each FSA CED will place in sealed... summaries. Such records will be placed under lock in a safe place under the custody of the FSA CED for a..., South Agriculture Building, 1400 Independence Avenue, SW., Washington, DC. A Marketing Programs Branch...

7 CFR 1230.637 - Disposition of ballots and records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Disposition of ballots and records. (a) Producer ballots and records. Each FSA CED will place in sealed... summaries. Such records will be placed under lock in a safe place under the custody of the FSA CED for a..., South Agriculture Building, 1400 Independence Avenue, SW., Washington, DC. A Marketing Programs Branch...

7 CFR 1220.629 - Disposition of records.

Code of Federal Regulations, 2014 CFR

2014-01-01

... records will be placed in a secure location under the custody of the FSA CED for a period of not less than... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.629 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Request for Soybean...

7 CFR 1280.632 - Disposition of records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... records will be placed in a secure location under the custody of FSA CED for a period of not less than 12... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.632 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Lamb Checkoff Program...

7 CFR 1280.632 - Disposition of records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... records will be placed in a secure location under the custody of FSA CED for a period of not less than 12... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.632 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Lamb Checkoff Program...

7 CFR 1220.629 - Disposition of records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... records will be placed in a secure location under the custody of the FSA CED for a period of not less than... CONSUMER INFORMATION Procedures To Request a Referendum Definitions § 1220.629 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Request for Soybean...

7 CFR 1280.632 - Disposition of records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... records will be placed in a secure location under the custody of FSA CED for a period of not less than 12... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.632 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Lamb Checkoff Program...

7 CFR 1280.632 - Disposition of records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... records will be placed in a secure location under the custody of FSA CED for a period of not less than 12... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.632 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Lamb Checkoff Program...

7 CFR 1280.632 - Disposition of records.

Code of Federal Regulations, 2014 CFR

2014-01-01

... records will be placed in a secure location under the custody of FSA CED for a period of not less than 12... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.632 Disposition of records. Each FSA CED will place in sealed containers marked with the identification of the “Lamb Checkoff Program...

78 FR 5176 - CED White River Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-764-000] CED White River Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... River Solar, LLC's application for market-based rate authority, with an accompanying rate schedule...

Humility pills: building an ethics of cognitive enhancement.

PubMed

Goodman, Rob

2014-06-01

The use of cognition-enhancing drugs (CEDs) appears to be increasingly common in both academic and workplace settings. But many universities and businesses have not yet engaged with the ethical challenges raised by CED use. This paper considers criticisms of CED use with a particular focus on the Accomplishment Argument: an influential set of claims holding that enhanced work is less dignified, valuable, or authentic, and that cognitive enhancement damages our characters. While the Accomplishment Argument assumes a view of authorship based on individual credit-taking, an impersonal or collaborative view is just as possible. This paper considers the benefits of this view-including humility, a value often claimed by critics of enhancement-and argues that such a view is consistent with open CED use. It proposes an ethics of cognitive enhancement based on toleration, transparency, and humility, and it discusses how institutions and individuals can build a culture of open cognitive enhancement. © The Author 2014. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The Effect of Less-Lethal Weapons on Injuries in Police Use-of-Force Events

PubMed Central

Kaminski, Robert J.; Smith, Michael R.

2009-01-01

Objectives. We investigated the effect of the use of less-lethal weapons, conductive energy devices (CEDs), and oleoresin capsicum (OC) spray on the prevalence and incidence of injuries to police officers and civilians in encounters involving the use of force. Methods. We analyzed data from 12 police departments that documented injuries to officers and civilians in 24 380 cases. We examined monthly injury rates for 2 police departments before and after their adoption of CEDs. Results. Odds of injury to civilians and officers were significantly lower when police used CED weapons, after control for differences in case attributes and departmental policies restricting use of these weapons. Monthly incidence of injury in 2 police departments declined significantly, by 25% to 62%, after adoption of CED devices. Conclusions. Injuries sustained during police use-of-force events affect thousands of police officers and civilians in the United States each year. Incidence of these injuries can be reduced dramatically when law enforcement agencies responsibly employ less-lethal weapons in lieu of physical force. PMID:19846686

Liposomal temozolomide drug delivery using convection enhanced delivery.

PubMed

Nordling-David, Mirjam M; Yaffe, Roni; Guez, David; Meirow, Hadar; Last, David; Grad, Etty; Salomon, Sharona; Sharabi, Shirley; Levi-Kalisman, Yael; Golomb, Gershon; Mardor, Yael

2017-09-10

Even though some progress in diagnosis and treatment has been made over the years, there is still no definitive treatment available for Glioblastoma multiforme (GBM). Convection-enhanced delivery (CED), a continuous infusion-mediated pressure gradient via intracranial catheters, studied in clinical trials, enables in situ drug concentrations several orders of magnitude greater than those achieved by systemic administration. We hypothesized that the currently limited efficacy of CED could be enhanced by a liposomal formulation, thus achieving enhanced drug localization to the tumor site with minimal toxicity. We hereby describe a novel approach for treating GBM by CED of liposomes containing the known chemotherapeutic agent, temozolomide (TMZ). A new technique for encapsulating TMZ in hydrophilic (PEGylated) liposomes, characterized by nano-size (121nm), low polydispersity index (<0.13) and with near-neutral charge (-ʒ,0.2mV), has been developed. Co-infusion of PEGylated Gd-DTPA liposomes and TMZ-liposomes by CED in GBM bearing rats, resulted in enhanced tumor detection with longer residence time than free Gd-DTPA. Treatment of GBM-bearing rats with either TMZ solution or TMZ-liposomes resulted in greater tumor inhibition and significantly higher survival. However, the longer survival and smaller tumor volumes exhibited by TMZ liposomal treatment in comparison to TMZ in solution were insignificant (p<0.053); and only significantly lower edema volumes were observed. Thus, there are no clear-cut advantages to use a liposomal delivery system of TMZ via CED over a drug solution. Copyright © 2017 Elsevier B.V. All rights reserved.

Consumption of Probiotic Lactobacillus fermentum MTCC: 5898-Fermented Milk Attenuates Dyslipidemia, Oxidative Stress, and Inflammation in Male Rats Fed on Cholesterol-Enriched Diet.

PubMed

Yadav, Radha; Khan, Suhail Hakeem; Mada, Sanusi Bello; Meena, Sunita; Kapila, Rajeev; Kapila, Suman

2018-05-13

There is a growing and alarming prevalence that increased serum cholesterol is closely related to increased cardiovascular disease risk. Probiotic consumption could be a safe and natural strategy to combat. Therefore, we sought to examine the cholesterol-lowering potential of co-supplementation of probiotic bacteria Lactobacillus fermentum MTCC: 5898-fermented buffalo milk (2.5% fat) in rats fed cholesterol-enriched diet. Male Wistar rats were divided into three groups on the basis of feed, viz. group 1, fed standard diet (SD); group 2, fed cholesterol-enriched diet (CED); and group 3, fed cholesterol-enriched diet along with L. fermentum MTCC: 5898-fermented milk (CED+LF) for 90 days. At the endpoint, significantly higher levels of serum total cholesterol, low-density lipoprotein cholesterol, triacylglycerols, very low density lipoprotein cholesterol, atherogenic index, coronary artery risk index, hepatic lipids, lipid peroxidation, and mRNA expression of inflammatory cytokines (TNF-α and IL-6) in the liver while significantly lower levels of serum high-density lipoprotein cholesterol and anti-oxidative enzyme activities, catalase, superoxide dismutase, and glutathione peroxidase in the liver and kidney were observed in the CED group compared to the SD group. Compared to the CED group, these adverse physiological alterations were found significantly improved in the CED+LF group. Hence, this study proposes that L. fermentum MTCC: 5898 is a potential probiotic bacteria that can be consumed to tackle hypercholesterolemia. Graphical Abstract ᅟ.

Traditional food consumption and nutritional status of Dalit mothers in rural Andhra Pradesh, South India.

PubMed

Schmid, M A; Egeland, G M; Salomeyesudas, B; Satheesh, P V; Kuhnlein, H V

2006-11-01

To describe prevalence of malnutrition and their correlates of nutrient and traditional food consumption in rural Dalit mothers. In a cross-sectional study, we used socio-cultural questionnaires, anthropometric measurements and clinical eye examinations during the rainy season in 2003. Food frequency questionnaires and 24-h recalls were conducted during both summer and rainy seasons. Dalit mothers with young children were recruited from 37 villages in the Medak District of rural Andhra Pradesh, India. Dalit mothers (n = 220) participated. The prevalence of chronic energy-deficient (CED) mothers (body mass index <18.5 kg/m2) was 58%. Illiterate women and active women were more likely to have CED than those literate and non-active (relative risks (RR) = 1.6 and 1.4, respectively, P < or = 0.05), but literacy and activity level were not significant in multivariable analyses including sanitation and number of children < or =5 years of age. Increasing levels of fat intake, as a percent of total energy, was significantly associated with lower risk of CED (RR of the lowest 25th percentile compared to those in the 75th percentile or above was 1.6, P < or = 0.05), findings that remained significant in multivariable analyses. Consumption of pulses (g/day) was also inversely related to CED in univariate and multivariable analyses. Carbohydrate intake, as a percent of total energy, was inversely related to percent energy from fat (r = -0.96, P < or = 0.01), and, although positively related to CED in univariate analyses, carbohydrate consumption was not significant in multivariable analyses. Mothers' age in years and income was positively related to vitamin A deficiency. These results confirm that CED and vitamin A malnutrition among Dalit women are predominant problems in this area. Increased consumption of local traditional Dalit food (particularly sorghum, pulses, vegetables and animal source food) should be incorporated as an important component of intervention strategies to improve nutritional status.

Poor drug distribution as a possible explanation for the results of the PRECISE trial.

PubMed

Sampson, John H; Archer, Gary; Pedain, Christoph; Wembacher-Schröder, Eva; Westphal, Manfred; Kunwar, Sandeep; Vogelbaum, Michael A; Coan, April; Herndon, James E; Raghavan, Raghu; Brady, Martin L; Reardon, David A; Friedman, Allan H; Friedman, Henry S; Rodríguez-Ponce, M Inmaculada; Chang, Susan M; Mittermeyer, Stephan; Croteau, David; Puri, Raj K

2010-08-01

Convection-enhanced delivery (CED) is a novel intracerebral drug delivery technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet clinical end points. Although this may be due to inactive agents or a failure to rigorously validate drug targets, the authors have previously demonstrated that catheter positioning plays a major role in drug distribution using this technique. The purpose of the present work was to retrospectively analyze the expected drug distribution based on catheter positioning data available from the CED arm of the PRECISE trial. Data on catheter positioning from all patients randomized to the CED arm of the PRECISE trial were available for analyses. BrainLAB iPlan Flow software was used to estimate the expected drug distribution. Only 49.8% of catheters met all positioning criteria. Still, catheter positioning score (hazard ratio 0.93, p = 0.043) and the number of optimally positioned catheters (hazard ratio 0.72, p = 0.038) had a significant effect on progression-free survival. Estimated coverage of relevant target volumes was low, however, with only 20.1% of the 2-cm penumbra surrounding the resection cavity covered on average. Although tumor location and resection cavity volume had no effect on coverage volume, estimations of drug delivery to relevant target volumes did correlate well with catheter score (p < 0.003), and optimally positioned catheters had larger coverage volumes (p < 0.002). Only overall survival (p = 0.006) was higher for investigators considered experienced after adjusting for patient age and Karnofsky Performance Scale score. The potential efficacy of drugs delivered by CED may be severely constrained by ineffective delivery in many patients. Routine use of software algorithms and alternative catheter designs and infusion parameters may improve the efficacy of drugs delivered by CED.

Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model

PubMed Central

Singleton, WG; Collins, AM; Bienemann, AS; Killick-Cole, CL; Haynes, HR; Asby, DJ; Butts, CP; Wyatt, MJ; Barua, NU; Gill, SS

2017-01-01

Background The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood–brain barrier when administered systemically. In this article, we describe the in vitro and in vivo efficacy of a novel water-soluble nano-micellar formulation of panobinostat designed for administration by convection enhanced delivery (CED). Materials and methods The in vitro efficacy of panobinostat-loaded nano-micelles against rat F98, human U87-MG and M059K glioma cells and against patient-derived glioma stem cells was measured using a cell viability assay. Nano-micelle distribution in rat brain was analyzed following acute CED using rhodamine-labeled nano-micelles, and toxicity was assayed using immunofluorescent microscopy and synaptophysin enzyme-linked immunosorbent assay. We compared the survival of the bioluminescent syngenic F98/Fischer344 rat glioblastoma model treated by acute CED of panobinostat-loaded nano-micelles with that of untreated and vehicle-only-treated controls. Results Nano-micellar panobinostat is cytotoxic to rat and human glioma cells in vitro in a dose-dependent manner following short-time exposure to drug. Fluorescent rhodamine-labelled nano-micelles distribute with a volume of infusion/volume of distribution (Vi/Vd) ratio of four and five respectively after administration by CED. Administration was not associated with any toxicity when compared to controls. CED of panobinostat-loaded nano-micelles was associated with significantly improved survival when compared to controls (n=8 per group; log-rank test, P<0.001). One hundred percent of treated animals survived the 60-day experimental period and had tumour response on post-mortem histological examination. Conclusion CED of nano-micellar panobinostat represents a potential novel therapeutic option for malignant glioma and warrants translation into the clinic. PMID:28260886

Determination of glycated nucleobases in human urine by a new monoclonal antibody specific for N2-carboxyethyl-2'-deoxyguanosine.

PubMed

Schneider, Marc; Thoss, Gerlinde; Hübner-Parajsz, Christa; Kientsch-Engel, Rose; Stahl, Peter; Pischetsrieder, Monika

2004-10-01

Sugars and sugar degradation products react in vivo readily with proteins (glycation) resulting in the formation of a heterogeneous group of reaction products, which are called advanced glycation end products (AGEs). AGEs notably change the structure and function of proteins so that extended protein-AGE formation is linked to complications such as nephropathy, atherosclerosis, and cataract. DNA can be glycated in vitro in a similar way as proteins, and the two diastereomers of N(2)-carboxyethyl-2'-deoxyguanosine (CEdG(A,B)) were identified as major DNA AGEs. It was postulated that DNA AGEs play an important role in aging, diabetes, and uremia. However, at the moment, sensitive methods to measure the extent and impact of DNA AGEs in vivo do not exist. In this study, we developed a monoclonal antibody, which recognized CEdG(A,B) with high affinity and specificity (MAb M-5.1.6). The I(50) value for CEdG(A,B) was 2.1 ng/mL, whereas other modified nuclueobases and AGE proteins showed negligible cross-reactivity. Unmodified 2'-deoxyguanosine was only weakly recognized with an I(50) value > 600,000 ng/mL, which is the limit of solubility. MAb M-5.1.6 was then used to measure the urinary excretion of AGE-modified nucleobases in a competitive enzyme-linked immunosorbent assay. The recovery of CEdG(A,B) from human urine was between 87.4 and 99.7% with coefficients of variations between 8.0 and 22.2%. The detection limit was 0.06 ng/mL, and the determination limit was 0.15 ng/mL with a linear range between 0.3 and 100 ng/mL. CEdG equivalents were analyzed in urine samples from 121 healthy volunteers, and concentrations between 1.2 and 117 ng CEdG equiv/mg creatinine were detected.

Repeat Intracranial Expansion After Skull Regrowth in Hyperostotic Disease: Technical Note.

PubMed

Wong, Timothy; Herschman, Yehuda; Patel, Nitesh V; Patel, Tushar; Hanft, Simon

2017-06-01

Camurati-Engelmann disease (CED) is a rare, autosomal-dominant genetic disorder resulting in hyperostosis of the long bones and skull. Patients often develop cranial nerve dysfunction and increased intracranial pressure secondary to stenosis of nerve foramina and hyperostosis. Surgical decompression may provide symptomatic relief in select patients; however, a small number of reports document the recurrence of symptoms due to bony regrowth. We present a patient who had been treated previously with bilateral frontal and parietal craniotomy who experienced recurrence of symptoms due to reossification of her cranial bones. This report underscores the progressive nature of CED and its influence on surgical management. Furthermore, we propose a novel surgical approach with multiple craniectomies and titanium mesh cranioplasties that could potentially offer long-term symptomatic relief. A 46-year-old female patient with CED who was treated with ventriculoperitoneal shunting, posterior fossa decompression, and multiple craniotomies 2 decades prior presented with signs and symptoms of increased intracranial pressure. Studies of the skull at presentation demonstrated rethickening of cranial bones that resulted in severely decreased intracranial volume. A radical craniectomy, requiring 4 separate bone flaps made up of bilateral frontal and parietal bones, was performed. The remaining coronal and sagittal bony struts were drilled to approximately 1 cm thick. Cranioplasties with 4 separate titanium meshes were performed to preserve the natural contour of the patient's skull. Although surgical decompression could provide some patients with CED symptomatic relief, clinicians should consider managing CED as a chronic condition. To the authors' knowledge, this is one of few case reports documenting the recurrence of symptoms in a patient with CED treated by surgical intervention. Furthermore, we propose that multiple craniectomies with titanium mesh cranioplasties confer more permanent symptomatic control, and, more importantly, lower the risk of recurrence secondary to cranial hyperostosis. Copyright © 2017 Elsevier Inc. All rights reserved.

Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms

PubMed Central

Li, Zao; Venegas, Victor; Nagaoka, Yuji; Morino, Eri; Raghavan, Prashant; Audhya, Anjon; Nakanishi, Yoshinobu; Zhou, Zheng

2015-01-01

Necrosis, a kind of cell death closely associated with pathogenesis and genetic programs, is distinct from apoptosis in both morphology and mechanism. Like apoptotic cells, necrotic cells are swiftly removed from animal bodies to prevent harmful inflammatory and autoimmune responses. In the nematode Caenorhabditis elegans, gain-of-function mutations in certain ion channel subunits result in the excitotoxic necrosis of six touch neurons and their subsequent engulfment and degradation inside engulfing cells. How necrotic cells are recognized by engulfing cells is unclear. Phosphatidylserine (PS) is an important apoptotic-cell surface signal that attracts engulfing cells. Here we observed PS exposure on the surface of necrotic touch neurons. In addition, the phagocytic receptor CED-1 clusters around necrotic cells and promotes their engulfment. The extracellular domain of CED-1 associates with PS in vitro. We further identified a necrotic cell-specific function of CED-7, a member of the ATP-binding cassette (ABC) transporter family, in promoting PS exposure. In addition to CED-7, anoctamin homolog-1 (ANOH-1), the C. elegans homolog of the mammalian Ca2+-dependent phospholipid scramblase TMEM16F, plays an independent role in promoting PS exposure on necrotic cells. The combined activities from CED-7 and ANOH-1 ensure efficient exposure of PS on necrotic cells to attract their phagocytes. In addition, CED-8, the C. elegans homolog of mammalian Xk-related protein 8 also makes a contribution to necrotic cell-removal at the first larval stage. Our work indicates that cells killed by different mechanisms (necrosis or apoptosis) expose a common “eat me” signal to attract their phagocytic receptor(s); furthermore, unlike what was previously believed, necrotic cells actively present PS on their outer surfaces through at least two distinct molecular mechanisms rather than leaking out PS passively. PMID:26061275

Analysis of environmental and general science efficacy among instructors with contrasting class ethnicity distributions: A four-dimensional assessment

NASA Astrophysics Data System (ADS)

Taylor, Bryan Keith

Scope and method of study. The context and nature of self-efficacy beliefs provides a vector upon which to explore science instructors' perceptions of their own competence, self beliefs, and beliefs concerning their students as a function of ethnicity (Pajares, 1996). Currently, available cross-sectional data that concomitantly compares efficacy for environmental and general science curricula among instructors with contrasting class ethnicity distributions (CED) (minority vs. non-minority) is diminutive. Here, a modified research instrument that incorporates the Environmental Education Efficacy Belief Instrument (Sia, 1992), the Science Teaching Efficacy Beliefs Instrument (Riggs & Enochs, 1990), and factors 2 & 3 from the Ohio State Teacher Efficacy Scale (Tschannen-Moran & Hoy, 2001) is employed to create a bi-disciplinary four dimensional assessment that measures personal teacher efficacy (PTE), outcome expectancy (OE), classroom management (CM), and student engagement (SE). Instructors' willingness to, and utilization of, practical instruction to reinforce science learning is also assessed. Findings and conclusions. Overall, efficacy levels for environmental and general science curriculum among instructors with high minority CED (n=22) were consistently lower than that of instructors with high non-minority CED (n = 18); consistently diminished efficacy levels were evidenced upon analysis of CED and all independent variables analyzed. While all four dimensions of efficacy were consistently low for instructors with high minority CED, markedly low mean CM and SE responses were evidenced. A link exists between teacher self-efficacy and the conditions present that impinge on the successful completion of work goals (Metz, 1978). Many studies have examined the lowered-level of minority involvement in environmental careers, issues, and concerns (Taylor, 1989). While all science instructors were willing to utilize outdoor classrooms, markedly lower outdoor classroom utilization was evidenced among instructors with high minority CED. The consistently low efficacy scores referenced herein for science instructors with high minority CED can be utilized to highlight science teacher efficacy as a critical point of concern as well as a crucial factor in tracing the genesis of the minority achievement gap in science. This research provides for the determination of efficacy as a contributive factor within the pathway for substantive rationale underlying the lack of minority representation and achievement within the many disciplines of science.

Summer School on Interstellar Processes: Abstracts of contributed papers

NASA Technical Reports Server (NTRS)

Hollenbach, D. J. (Editor); Thronson, H. A., Jr. (Editor)

1986-01-01

The Summer School on Interstellar Processes was held to discuss the current understanding of the interstellar medium and to analyze the basic physical processes underlying interstellar phenomena. Extended abstracts of the contributed papers given at the meeting are presented. Many of the papers concerned the local structure and kinematics of the interstellar medium and focused on such objects as star formation regions, molecular clouds, HII regions, reflection nebulae, planetary nebulae, supernova remnants, and shock waves. Other papers studied the galactic-scale structure of the interstellar medium either in the Milky Way or other galaxies. Some emphasis was given to observations of interstellar grains and

James Dunlop's historical catalogue of southern nebulae and clusters

NASA Astrophysics Data System (ADS)

Cozens, Glen; Walsh, Andrew; Orchiston, Wayne

2010-03-01

In 1826 James Dunlop compiled the second ever catalogue of southern star clusters, nebulae and galaxies from Parramatta (NSW, Australia) using a 23-cm reflecting telescope. Initially acclaimed, the catalogue and author were later criticised and condemned by others - including Sir John Herschel and both the catalogue and author are now largely unknown. The criticism of the catalogue centred on the large number of fictitious or ‘missing’ objects, yet detailed analysis reveals the remarkable completeness of the catalogue, despite its inherent errors. We believe that James Dunlop was an important early Australian astronomer, and his catalogue should be esteemed as the southern equivalent of Messier's famous northern catalogue.

The "Water-Fountain Nebula" IRAS 16342-3814: Hubble Space Telescope/Very Large Array Study of a Bipolar Protoplanetary Nebula

NASA Technical Reports Server (NTRS)

Sahal, Raghvendra; teLintelHekkert, Peter; Morris, Mark; Zijlstra, Albert; Likkel, Lauren

1999-01-01

We present Hubble Space Telescope (HST) Wide-Field Planetary Camera 2 images and VLA OH maser emission-line maps of the cold infrared object IRAS 16342-3814, believed to be a protoplanetary nebula. The HST images show an asymmetrical bipolar nebula, with the lobes separated by a dark equatorial waist. The two bright lobes and the dark waist are simply interpreted as bubble-like reflection nebulae illuminated by starlight escaping through polar holes in a dense, flattened, optically thick cocoon of dust, which completely obscures the central star. A faint halo can be seen surrounding each of the lobes. The bubbles are likely to have been created by a fast outflow (evidenced by H2O emission) plowing into a surrounding dense, more slowly expanding, circumstellar envelope of the progenitor asymptotic giant-branch (AGB) star (evidenced by the halo). The IRAS fluxes indicate a circumstellar mass of about 0.7 solar mass (D/2 kpc) and an AGB mass-loss rate of about 10(exp -4) solar mass/yr (V(sub exp)/15 km/s)(D/2 kpc)(sup 2) (assuming a gas-to-dust ratio of 200). OH features with the largest redshifted and blueshifted velocities are concentrated around the bright eastern and western polar lobes, respectively, whereas intermediate-velocity features generally occur at low latitudes, in the dark waist region. We critically examine evidence for the post-AGB classification of IRAS 16342-3814.

The Asymmetric Nebula Surrounding the Extreme Red Supergiant VY Canis Majoris

NASA Astrophysics Data System (ADS)

Smith, Nathan; Humphreys, Roberta M.; Davidson, Kris; Gehrz, Robert D.; Schuster, M. T.; Krautter, Joachim

2001-02-01

We present HST/WFPC2 images plus ground-based infrared images and photometry of the very luminous OH/IR star VY Canis Majoris. Our WFPC2 data show a complex distribution of knots and filamentary arcs in the asymmetric reflection nebula around the obscured central star. The reflection arcs may result from multiple, asymmetric ejection episodes due to localized events on VY CMa's surface. Such events probably involve magnetic fields and convection, by analogy with solar activity. Surface photometry indicates that the star may have experienced enhanced mass loss over the past 1000 yr. We also demonstrate that the apparent asymmetry of the nebula results from a combination of high extinction and backscattering by dust grains. Thermal-infrared images reveal a more symmetric distribution, elongated along a nearly east-west direction. VY CMa probably has a flattened disklike distribution of dust with a northeast-southwest polar axis and may be experiencing activity analogous to solar prominences. The presence of an axis of symmetry raises interesting questions for a star the size of Saturn's orbit. Magnetic fields and surface activity may play an important role in VY CMa's mass-loss history. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555.

A New Partnership: Reshaping the Federal and State Commitment to Need-Based Aid

ERIC Educational Resources Information Center

Doyle, William R.

2013-01-01

The Committee for Economic Development (CED) is pleased to present these research findings regarding ways to reform student financial aid. In 2012, CED released "Boosting Postsecondary Education Performance"--calling on business to become active advocates at the state level for broad-access institutions that are so vital to the nation's…

Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies

PubMed Central

Jahangiri, Arman; Chin, Aaron T.; Flanigan, Patrick M.; Chen, Rebecca; Bankiewicz, Krystof; Aghi, Manish K.

2017-01-01

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail. PMID:27035164

Medical regulation of cognitive enhancement devices: some concerns

PubMed Central

King, Mike; Gavaghan, Colin; McMillan, John

2014-01-01

The authors present a cogent and detailed case for altering the Medical Devices Directive to allow regulation of cognitive enhancement devices (CEDs). Protection against significant risk of harm, especially for the vulnerable, and promotion of benefit through informed use of CEDs are all good features of the proposal. However, the pre-market approval process has limitations, which we explore. We raise the possibility of ‘risk compensation’ in response to the introduction of safety measures, which could alter its effectiveness. The proposal alludes to use of ‘formally trained practitioners,’ which provide a further tier of regulation for CEDs within the proposal. We consider some positive and negative implications of this aspect of the proposal that might warrant further consideration. PMID:27774173

Biomedical study on combined effects of simulated weightlessness and emergent depressurization of spacecraft

NASA Astrophysics Data System (ADS)

Yang, T. D.; Zhang, R. G.; Wang, C. M.; Fu, H. W.; Zhang, B. L.; Zhang, J. X.

1999-01-01

Cabin emergent depressurization (CED) may occur in spacecraft during manned space flight. The purpose of this paper was to study the combined effects of simulated weightlessness (SW) and CED factors on humans and animals. It was found that the amplitude of T wave of human electrocardiograms (ECG) significantly decreased in bed rest and hypoxia compared with the control condition (P<0.05), and that suspension with pure O2 induced severer edema in the lungs of rats than that in only a pure O2 environment. SW and pure O2 caused middle ear congestion and decreased the barofunction during pressure changes. These results indicate that human response to CED factors become more serious under SW because of the blood redistribution.

[Pay attention to the corneal epithelial cell dysfunction after cataract surgery].

PubMed

Sun, Xuguang; Wang, Sen

2015-03-01

Corneal epithelial dysfunction ( CED ) is the abnormality of the regeneration, conjunction, adhesion and immigration of the corneal epithelium cells without the decompensation of the corneal limbal cells. Due to the affection resulting from the systemic problems of patients and the management in the preoperative period, some of the patients at one to two weeks after cataract surgery will present the edema and fluorescein staining of the corneal epithelium. Without correct therapy, the defect of the epithelium, or even persisting ulceration of the cornea will occur. The key points of the management for CED are the early diagnosis and reasonable therapy. We suggest paying special attention to CED in the patients with metabolism diseases, abnormality of the tear film and long-term blepharitis.

The perspective of celiac disease patients on emerging treatment options and non-celiac gluten sensitivity.

PubMed

Greuter, Thomas; Schmidlin, Sandra; Lattmann, Jaqueline; Stotz, Matthias; Lehmann, Romina; Zeitz, Jonas; Scharl, Michael; Misselwitz, Benjamin; Pohl, Daniel; Fried, Michael; Tutuian, Radu; Fasano, Alessio; Schoepfer, Alain M; Rogler, Gerhard; Biedermann, Luc; Vavricka, Stephan R

2017-03-01

Non-celiac gluten sensitivity (NCGS) and emerging treatment options are hot topics in the celiac disease (CeD) scientific literature. However, very little is known about the perspective on these issues of CeD patients. We performed a large patient survey among unselected CeD patients in Switzerland. A total of 1689 patients were analyzed. 57.5% have previously heard of NCGS. 64.5% believe in the existence of this entity. Regarding a potential influence of NCGS on CeD awareness, 31.7% show a positive and 27.5% a negative perception. Patients with prior use of alternative medicine and women more often have heard of and believe in the existence of NCGS vs. those never having used alternative methods and men, respectively (66.9 vs. 56.9%, p=0.001 and 78.5 vs. 69.0%, p=0.001; 60.7 vs. 44.2%, p<0.001 and 71.0 vs. 60.8%, p=0.002). Women and patients ≥30 years more often show a negative attitude towards NCGS (32.2% vs. 24.8%, p=0.024 and 32.2% vs. 24.2%, p=0.018). With regard to emerging treatment options for CeD, 43.3% have previously heard of novel agents, more women than men (46.0 vs. 38.0%, p=0.019). Perception of and attitude towards NCGS differ depending on sex, age and prior use of alternative medicine. Knowledge of the progress towards emerging treatment options is currently limited. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

New insights into apoptosome structure and function.

PubMed

Dorstyn, Loretta; Akey, Christopher W; Kumar, Sharad

2018-05-15

The apoptosome is a platform that activates apical procaspases in response to intrinsic cell death signals. Biochemical and structural studies in the past two decades have extended our understanding of apoptosome composition and structure, while illuminating the requirements for initiator procaspase activation. A number of studies have now provided high-resolution structures for apoptosomes from C. elegans (CED-4), D. melanogaster (Dark), and H. sapiens (Apaf-1), which define critical protein interfaces, including intra and interdomain interactions. This work also reveals interactions of apoptosomes with their respective initiator caspases, CED-3, Dronc and procaspase-9. Structures of the human apoptosome have defined the requirements for cytochrome c binding, which triggers the conversion of inactive Apaf-1 molecules to an extended, assembly competent state. While recent data have provided a detailed understanding of apoptosome formation and procaspase activation, they also highlight important evolutionary differences with functional implications for caspase activation. CARD/CARD interactions in the CED-4, Dark and Apaf-1 apoptosomes. Type I, II and III interfaces that stabilize CARD-CARD interactions are indicated (left column). Note that the Type I interface appears to be unique to Apaf-1/pc-9 CARD interactions. Middle column shows cartoons of the active states of the CARD-CARD disks, illustrating the two CED-4 tetrameric ring layers (top) and the recruitment of 8 Dronc CARDs and between 3-4 pc-9 CARDs, to the Dark and Apaf-1 apoptosomes respectively (middle and lower panels). Ribbon diagrams of the CED-4, Dark and Apaf-1 apoptosomes are shown (right column).

Synthesis and photocatalytic studies of ZnS nanoparticles from heteroleptic complex of Zn(II) 1-cyano-1-carboethoxy-2,-2-ethylenedithiolato diisopropylthiourea and its adducts with N-donor ligands

NASA Astrophysics Data System (ADS)

Osuntokun, Jejenija; Ajibade, Peter A.; Onwudiwe, Damian C.

2016-12-01

Zinc complexes of the type [Zn(diptu)2(ced)] (1), [Zn(diptu)2(ced)py] (2), [Zn(diptu)2(ced)bpy] (3), and [Zn(diptu)2(ced)phen] (4), (where (diptu)2(ced) = 1-cyano-1-carboethoxyethylene-2,2-dithiolato-κS,S‧-bis(N,N-diisopropyllthiourea), py = pyridine, bpy = 2, 2‧ bipyridine and phen = 1, 10 phenanthroline have been synthesized and characterized by elemental analyses, Fourier transform infra-red (FTIR) and Nuclear magnetic resonance (NMR) spectroscopies. The parent complex (1) was formulated as four coordinate species, which gave rise to 5 coordinate complex in (2) and six coordinate compounds in (3) and (4), with the dithiolate acting as bidentate chelating ligand. The complexes were used as single-source precursors for the synthesis of HDA-capped ZnS nanoparticles. The nanoparticles gave different morphologies with sizes in the range of 1.92-4.72 nm as observed from the TEM analysis and supported by XRD. The UV-vis spectroscopy showed that all the ZnS nanoparticles are blue shifted, with respect to the bulk, which confirmed quantum confinement. The photoluminescence spectra showed narrow and broad emission peaks around 290 and 360 nm which are ascribed to spontaneous emission peaks from band to band transition and surface states respectively. Photocatalytic activities of all the nanoparticles were investigated with methylene blue (MB) acting as the organic dye, and the UV-vis spectral revealed a gradual decrease in absorption peak that confirmed the degradation of the MB.

Perspectives on a Policy That Never Was: Trying To Enhance Multiculturalism in a University Setting.

ERIC Educational Resources Information Center

Greenwald, Beatrice

This paper discusses the failure of the University of Washington to formulate a policy regarding the establishment of a Cultural and Ethnic Diversity (CED) course requirement for undergraduates despite nine years of efforts to do so, tracing the efforts to establish a CED requirement, along with the arguments for and against such a requirement. It…

Correlated electronic decay in expanding clusters triggered by intense XUV pulses from a Free-Electron-Laser

PubMed Central

Oelze, Tim; Schütte, Bernd; Müller, Maria; Müller, Jan P.; Wieland, Marek; Frühling, Ulrike; Drescher, Markus; Al-Shemmary, Alaa; Golz, Torsten; Stojanovic, Nikola; Krikunova, Maria

2017-01-01

Irradiation of nanoscale clusters and large molecules with intense laser pulses transforms them into highly-excited non- equilibrium states. The dynamics of intense laser-cluster interaction is encoded in electron kinetic energy spectra, which contain signatures of direct photoelectron emission as well as emission of thermalized nanoplasma electrons. In this work we report on a so far not observed spectrally narrow bound state signature in the electron kinetic energy spectra from mixed Xe core - Ar shell clusters ionized by intense extreme-ultraviolet (XUV) pulses from a free-electron-laser. This signature is attributed to the correlated electronic decay (CED) process, in which an excited atom relaxes and the excess energy is used to ionize the same or another excited atom or a nanoplasma electron. By applying the terahertz field streaking principle we demonstrate that CED-electrons are emitted at least a few picoseconds after the ionizing XUV pulse has ended. Following the recent finding of CED in clusters ionized by intense near-infrared laser pulses, our observation of CED in the XUV range suggests that this process is of general relevance for the relaxation dynamics in laser produced nanoplasmas. PMID:28098175

Convection-enhanced delivery for the treatment of brain tumors

PubMed Central

Debinski, Waldemar; Tatter, Stephen B

2013-01-01

The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment. Drugs are delivered through one to several catheters placed stereotactically directly within the tumor mass or around the tumor or the resection cavity. Several classes of drugs are amenable to this technology including standard chemotherapeutics or novel experimental targeted drugs. The first Phase III trial for CED-delivered, molecularly targeted cytotoxin in the treatment of recurrent glioblastoma multiforme has been accomplished and demonstrated objective clinical efficacy. The lessons learned from more than a decade of attempts at exploiting CED for brain cancer treatment weigh critically for its future clinical applications. The main issues center around the type of catheters used, number of catheters and their exact placement; pharmacological formulation of drugs, prescreening patients undergoing treatment and monitoring the distribution of drugs in tumors and the tumor-infiltrated brain. It is expected that optimizing CED will make this technology a permanent addition to clinical management of brain malignancies. PMID:19831841

Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts

PubMed Central

Krauze, Michal T.; Noble, Charles O.; Kawaguchi, Tomohiro; Drummond, Daryl; Kirpotin, Dmitri B.; Yamashita, Yoji; Kullberg, Erika; Forsayeth, John; Park, John W.; Bankiewicz, Krystof S.

2007-01-01

We have previously shown that convection-enhanced delivery (CED) of highly stable nanoparticle/liposome agents encapsulating chemotherapeutic drugs is effective against intracranial rodent brain tumor xenografts. In this study, we have evaluated the combination of a newly developed nanoparticle/liposome containing the topoisomerase I inhibitor CPT-11 (nanoliposomal CPT-11 [nLs-CPT-11]), and PEGylated liposomal doxorubicin (Doxil) containing the topoisomerase II inhibitor doxorubicin. Both drugs were detectable in the CNS for more than 36 days after a single CED application. Tissue half-life was 16.7 days for nLs-CPT-11 and 10.9 days for Doxil. The combination of the two agents produced synergistic cytotoxicity in vitro. In vivo in U251MG and U87MG intracranial rodent xenograft models, CED of the combination was also more efficacious than either agent used singly. Analysis of the parameters involved in this approach indicated that tissue pharmacokinetics, tumor microanatomy, and biochemical interactions of the drugs all contributed to the therapeutic efficacy observed. These findings have implications for further clinical applications of CED-based treatment of brain tumors. PMID:17652269

Drug-carrying microbubbles as a theranostic tool in convection-enhanced delivery for brain tumor therapy.

PubMed

Chen, Pin-Yuan; Yeh, Chih-Kuang; Hsu, Po-Hung; Lin, Chung-Yin; Huang, Chiung-Yin; Wei, Kuo-Chen; Liu, Hao-Li

2017-06-27

Convection-enhanced delivery (CED) is a promising technique for infusing a therapeutic agent through a catheter with a pressure gradient to create bulk flow for improving drug spread into the brain. So far, gadopentetate dimeglumine (Gd-DTPA) is the most commonly applied surrogate agent for predicting drug distribution through magnetic resonance imaging (MRI). However, Gd-DTPA provides only a short observation duration, and concurrent infusion provides an indirect measure of the exact drug distribution. In this study, we propose using microbubbles as a contrast agent for MRI monitoring, and evaluate their use as a drug-carrying vehicle to directly monitor the infused drug. Results show that microbubbles can provide excellent detectability through MRI relaxometry and accurately represent drug distribution during CED infusion. Compared with the short half-life of Gd-DTPA (1-2 hours), microbubbles allow an extended observation period of up to 12 hours. Moreover, microbubbles provide a sufficiently high drug payload, and glioma mice that underwent a CED infusion of microbubbles carrying doxorubicin presented considerable tumor growth suppression and a significantly improved survival rate. This study recommends microbubbles as a new theranostic tool for CED procedures.

The CEBAF Element Database

DOE Office of Scientific and Technical Information (OSTI.GOV)

Theodore Larrieu, Christopher Slominski, Michele Joyce

2011-03-01

With the inauguration of the CEBAF Element Database (CED) in Fall 2010, Jefferson Lab computer scientists have taken a step toward the eventual goal of a model-driven accelerator. Once fully populated, the database will be the primary repository of information used for everything from generating lattice decks to booting control computers to building controls screens. A requirement influencing the CED design is that it provide access to not only present, but also future and past configurations of the accelerator. To accomplish this, an introspective database schema was designed that allows new elements, types, and properties to be defined on-the-fly withmore » no changes to table structure. Used in conjunction with Oracle Workspace Manager, it allows users to query data from any time in the database history with the same tools used to query the present configuration. Users can also check-out workspaces to use as staging areas for upcoming machine configurations. All Access to the CED is through a well-documented Application Programming Interface (API) that is translated automatically from original C++ source code into native libraries for scripting languages such as perl, php, and TCL making access to the CED easy and ubiquitous.« less

A Non-Polarimetrist's Cookbook for Interpreting Polarimetric Observations

NASA Astrophysics Data System (ADS)

Nordsieck, K. H.

1996-05-01

The last ten years has seen an explosion in the available techniques of astronomical polarimetry, with imaging polarimeters and spectropolarimeters becoming more common and the wavelength range expanding from the visible and radio into the vacuum ultraviolet and the thermal infrared. What is the non-specialist to make of the newly available data- what does it mean? As the volume of data on all varieties of astronomical objects has expanded, common signatures are emerging. In this talk I will attempt to illustrate briefly some of these signatures with recent results which will be enlarged upon in other papers in this session. Some of these are variability signatures from filter polarimetry, geometry of the interstellar magnetic field and of dust reflection nebulae from imaging polarimetry, and spectropolarimetric signatures of interstellar dust, "hidden sources" seen by reflection, electron scattering, photospheric scattering, bipolar nebulae, and magnetic fields. Astronomical polarimetry at the University of Wisconsin is supported by NASA contracts NAS5-26777 and NAG5-647.

Periodic Application of Concurrent Error Detection in Processor Array Architectures. PhD. Thesis -

NASA Technical Reports Server (NTRS)

Chen, Paul Peichuan

1993-01-01

Processor arrays can provide an attractive architecture for some applications. Featuring modularity, regular interconnection and high parallelism, such arrays are well-suited for VLSI/WSI implementations, and applications with high computational requirements, such as real-time signal processing. Preserving the integrity of results can be of paramount importance for certain applications. In these cases, fault tolerance should be used to ensure reliable delivery of a system's service. One aspect of fault tolerance is the detection of errors caused by faults. Concurrent error detection (CED) techniques offer the advantage that transient and intermittent faults may be detected with greater probability than with off-line diagnostic tests. Applying time-redundant CED techniques can reduce hardware redundancy costs. However, most time-redundant CED techniques degrade a system's performance.

Unfinished Business: Continued Investment in Child Care and Early Education is Critical to Business and America's Future

ERIC Educational Resources Information Center

Committee for Economic Development, 2012

2012-01-01

The Committee for Economic Development (CED) has a decades-old commitment to quality early childhood education. CED Trustees have always been in the forefront of the effort to promote early learning and development for all children. Over recent years, the case for investment in the early years of childhood has become stronger and more urgent.…

The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: Synergism with the benzodiazepine diazepam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schultz, M.K.; Wright, L.K.M.; Stone, M.F.

2012-03-15

Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric acid A (GABA{sub A}) receptors. However, seizure activity itself causes the endocytosis of GABA{sub A} receptors and diminishes the inhibitory effects of GABA, thereby reducing the efficacy of DZP. Treatment with an N-methyl-D-aspartic acid (NMDA) receptor antagonist prevents this reduction in GABAergic inhibition. We examined the efficacy of the NMDA receptor antagonist caramiphen edisylate (CED; 20 mg/kg, im) and DZP (10 mg/kg, sc), administered both separately and in combination, at 10, 20 or 30 min followingmore » seizure onset for attenuation of the deleterious effects associated with GD exposure (1.2 LD{sub 50}; 132 μg/kg, sc) in rats. Outcomes evaluated were seizure duration, neuropathology, acetylcholinesterase (AChE) activity, body weight, and temperature. We also examined the use of the reversible AChE inhibitor physostigmine (PHY; 0.2 mg/kg, im) as a therapy for GD exposure. We found that the combination of CED and DZP yielded a synergistic effect, shortening seizure durations and reducing neuropathology compared to DZP alone, when treatment was delayed 20–30 min after seizure onset. PHY reduced the number of animals that developed seizures, protected a fraction of AChE from GD inhibition, and attenuated post-exposure body weight and temperature loss independent of CED and/or DZP treatment. We conclude that: 1) CED and DZP treatment offers considerable protection against the effects of GD and 2) PHY is a potential therapeutic option following GD exposure, albeit with a limited window of opportunity. -- Highlights: ► Soman (GD) produced seizure activity resulting in neuropathology in rats. ► Tx: caramiphen (CED) and/or diazepam (DZP) @ 10, 20 or 30 min after seizure onset. ► CED/DZP showed superior anticonvulsant and neuroprotective capacity. ► Physostigmine (PHY) was examined as an adjunct post-exposure therapy. ► PHY attenuated GD-induced seizure development, but not seizure duration.« less

Space Science

NASA Image and Video Library

2002-04-02

Resembling a nightmarish beast rearing its head from a crimson sea, this monstrous object is actually an irnocuous pillar of gas and dust. Called the Cone Nebula (NGC 2264), this giant pillar resides in a turbulent star-forming region. This picture, taken by the newly installed Advanced Camera for Surveys (ACS) aboard Hubble Space Telescope (HST) during Space Shuttle STS-109 mission in March 2002, shows the upper 2.5 light-years of the nebula, a height that equals 23 million roundtrips to the Moon. The entire nebula is 7 light-years long. The Cone Nebula resides 2,500 light-years away in the constellation Monoceros. Radiation from hot, young stars (located beyond the top of the image) has slowly eroded the nebula over millions of years. Ultraviolet light heats the edges of the dark cloud, releasing gas into the relatively empty region of surrounding space. There, additional ultraviolet radiation causes the hydrogen gas to glow, which produces the red halo of light seen around the pillar. A similar process occurs on a much smaller scale to gas surrounding a single star, forming the bow-shaped arc seen near the upper left side of the Cone. This arc, seen previously with the HST, is 65 times larger than the diameter of our solar system. The blue-white light from surrounding stars is reflected by dust. Background stars can be seen peeking through the evaporating tendrils of gas, while the turbulent base is pockmarked with stars reddened by dust. Credit: NASA, H. Ford (JHU), G. Illingworth (USCS/LO), M. Clampin (STScI), G. Hartig (STScI), the ACS Science Team, and ESA.

Cumulative radiation dose caused by radiologic studies in critically ill trauma patients.

PubMed

Kim, Patrick K; Gracias, Vicente H; Maidment, Andrew D A; O'Shea, Michael; Reilly, Patrick M; Schwab, C William

2004-09-01

Critically ill trauma patients undergo many radiologic studies, but the cumulative radiation dose is unknown. The purpose of this study was to estimate the cumulative effective dose (CED) of radiation resulting from radiologic studies in critically ill trauma patients. The study group was composed of trauma patients at an urban Level I trauma center with surgical intensive care unit length of stay (LOS) greater than 30 days. The radiology records were reviewed. A typical effective dose per study for each type of plain film radiograph, computed tomographic scan, fluoroscopic study, and nuclear medicine study was used to calculate CED. Forty-six patients met criteria. The mean surgical intensive care unit and hospital LOS were 42.7 +/- 14.0 and 59.5 +/- 28.5 days, respectively. The mean Injury Severity Score was 32.2 +/- 15.0. The mean number of studies per patient was 70.1 +/- 29.0 plain film radiographs, 7.8 +/- 4.1 computed tomographic scans, 2.5 +/- 2.6 fluoroscopic studies, and 0.065 +/- 0.33 nuclear medicine study. The mean CED was 106 +/- 59 mSv per patient (range, 11-289 mSv; median, 104 mSv). Among age, mechanism, Injury Severity Score, and LOS, there was no statistically significant predictor of high CED. The mean CED in the study group was 30 times higher than the average yearly radiation dose from all sources for individuals in the United States. The theoretical additional morbidity attributable to radiologic studies was 0.78%. From a radiobiologic perspective, risk-to-benefit ratios of radiologic studies are favorable, given the importance of medical information obtained. Current practice patterns regarding use of radiologic studies appear to be acceptable.

Health technology assessment in Switzerland: a descriptive analysis of “Coverage with Evidence Development” decisions from 1996 to 2013

PubMed Central

Brügger, Urs; Horisberger, Bruno; Ruckstuhl, Alexander; Plessow, Rafael; Eichler, Klaus; Gratwohl, Alois

2015-01-01

Objectives To identify factors associated with the decisions of the Federal Department of Home Affairs concerning coverage with evidence development (CED) for contested novel medical technologies in Switzerland. Design Quantitative, retrospective, descriptive analysis of publicly available material and prospective, structured, qualitative interviews with key stakeholders. Setting All 152 controversial medical services decided on by the Federal Commission on Health Insurance Benefits within the framework of the new federal law on health insurance in Switzerland from 1997 to 2013, with focus on 33 technologies assigned initially to CED and 33 to evidence development without coverage. Main outcome measures Factors associated with numbers and type of contested services assigned to CED per year, the duration and final outcome of the evaluations and perceptions of key stakeholders. Results The rate of CED decisions (82 total; median 1.5/year; range 0–9/year), the time to final decision (4.5 years median; 0.75 to +11 years) and the probability of a final ‘yes’ varied over time. In logistic regression models, the change of office of the commission provided the best explanation for the observed outcomes. Good intentions but absence of scientific criteria for decisions were reported as major comments by the stakeholders. Conclusions The introduction of CED enabled access to some promising technologies early in their life cycle, and might have triggered establishment of registries and research. Impact on patients’ outcome and costs remain unknown. The primary association of institutional changes with measured end points illustrates the need for evaluation of the current health technology assessment (HTA) system. PMID:25818273

Infusion-line pressure as a real-time monitor of convection-enhanced delivery in pre-clinical models.

PubMed

Lam, Miu Fei; Foo, Stacy W L; Thomas, Meghan G; Lind, Christopher R P

2014-01-15

Acute convection-enhanced delivery (CED) is a neurosurgical delivery technique that allows for precise and uniform distribution of an infusate to a brain structure. It remains experimental due to difficulties in ensuring successful delivery. Real-time monitoring is able to provide immediate feedback on cannula placement, infusate distribution, and if the infusion is proceeding as planned or is failing due to reflux or catheter obstruction. Pressure gradient is the driving force behind CED, with the infusion pressure being directly proportional to the flow-rate. The aim of this study was to assess the feasibility of using infusion-line pressure profiling to distinguish in real-time between succeeding and failing CED infusions. To do so we delivered cresyl violet dye at 0.5, 1.0 and 2.0 μl/min via CED in vitro using 0.6% agarose gel and in vivo to the rat striatum. Infusions that failed in agarose gel models could only be differentiated late during the procedures. In the rat in vivo model, the infusion-line profiles of obstructed infusions were not distinctive from those of successful infusions. Intraoperative magnetic resonance imaging (MRI) is used for real-time visualisation of cannula placement and infusate distribution. Particularly for animal pre-clinical work, it would be advantageous to supplement MRI with a cheap, accessible technique to monitor infusions and provide a real-time measure of infusion success or failure. Infusion-line pressure monitoring was of limited value in identifying successful CED with small volume infusions, whilst its utility for large volume infusion remains unknown. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

Convection-enhanced delivery of sorafenib and suppression of tumor progression in a murine model of brain melanoma through the inhibition of signal transducer and activator of transcription 3.

PubMed

Zou, Zhaoxia; Yin, Yufang; Lin, Jenny; Hsu, Li-Chen J; Brandon, Vanessa L; Yang, Fan; Jove, Richard; Jandial, Rahul; Li, Gang; Chen, Mike Y

2016-05-01

OBJECT Despite recent advances, metastatic melanoma remains a terminal disease, in which life-threatening brain metastasis occurs in approximately half of patients. Sorafenib is a multikinase inhibitor that induces apoptosis of melanoma cells in vitro. However, systemic administration has been ineffective because adequate tissue concentrations cannot be achieved. This study investigated if convection-enhanced delivery (CED) of sorafenib would enhance tumor control and survival via inhibition of the signal transducer and activator of transcription 3 (Stat3) pathway in a murine model of metastatic brain melanoma. METHODS Melanoma cells treated with sorafenib in vitro were examined for signaling and survival changes. The effect of sorafenib given by CED was assessed by bioluminescent imaging and animal survival. RESULTS The results showed that sorafenib induced cell death in the 4 established melanoma cell lines and in 1 primary cultured melanoma cell line. Sorafenib inhibited Stat3 phosphorylation in HTB65, WYC1, and B16 cells. Accordingly, sorafenib treatment also decreased expression of Mcl-1 mRNA in melanoma cell lines. Because sorafenib targets multiple pathways, the present study demonstrated the contribution of the Stat3 pathway by showing that mouse embryonic fibroblast (MEF) Stat3 +/+ cells were significantly more sensitive to sorafenib than MEF Stat3 -/- cells. In the murine model of melanoma brain metastasis used in this study, CED of sorafenib increased survival by 150% in the treatment group compared with animals receiving the vehicle control (p < 0.01). CED of sorafenib also significantly abrogated tumor growth. CONCLUSIONS The data from this study indicate that local delivery of sorafenib effectively controls brain melanoma. These findings validate further investigation of the use of CED to distribute molecularly targeted agents.

A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease.

PubMed

Hrdlickova, Barbara; Mulder, Chris J; Malamut, Georgia; Meresse, Bertrand; Platteel, Mathieu; Kamatani, Yoichiro; Ricaño-Ponce, Isis; van Wanrooij, Roy L J; Zorro, Maria M; Jan Bonder, Marc; Gutierrez-Achury, Javier; Cellier, Christophe; Zhernakova, Alexandra; Nijeboer, Petula; Galan, Pilar; Withoff, Sebo; Lathrop, Mark; Bouma, Gerd; Xavier, Ramnik J; Jabri, Bana; Bensussan, Nadine C; Wijmenga, Cisca; Kumar, Vinod

2018-05-21

Approximately 5% of patients with celiac disease (CeD) do not respond to a gluten-free diet and progress to refractory celiac disease (RCD), a severe progression that is characterized by infiltration of intraepithelial T lymphocytes. Patients with RCD type II (RCDII) show clonal expansions of intraepithelial T lymphocytes that result in a poor prognosis and a high mortality rate through development of aggressive enteropathy-associated T-cell lymphoma. It is not known whether genetic variations play a role in severe progression of CeD to RCDII. We performed the first genome-wide association study to identify the causal genes for RCDII and the molecular pathways perturbed in RCDII. The genome-wide association study was performed in 38 Dutch patients with RCDII, and the 15 independent top-associated single nucleotide polymorphism (SNP) variants (P<5×10) were replicated in 56 independent French and Dutch patients with RCDII. After replication, SNP rs2041570 on chromosome 7 was significantly associated with progression to RCDII (P=2.37×10, odds ratio=2.36) but not with CeD susceptibility. SNP rs2041570 risk allele A was associated with lower levels of FAM188B expression in blood and small intestinal biopsies. Stratification of RCDII biopsies based on rs2041570 genotype showed differential expression of innate immune and antibacterial genes that are expressed in Paneth cells. We have identified a novel SNP associated with the severe progression of CeD to RCDII. Our data suggest that genetic susceptibility to CeD might be distinct from the progression to RCDII and suggest a role for Paneth cells in RCDII progression.

Mutagenesis and repair induced by the DNA advanced glycation end product N2-1-(carboxyethyl)-2'-deoxyguanosine in human cells.

PubMed

Tamae, Daniel; Lim, Punnajit; Wuenschell, Gerald E; Termini, John

2011-03-29

Glycation of biopolymers by glucose-derived α-oxo-aldehydes such as methylglyoxal (MG) is believed to play a major role in the complex pathologies associated with diabetes and metabolic disease. In contrast to the extensive literature detailing the formation and physiological consequences of protein glycation, there is little information about the corresponding phenomenon for DNA. To assess the potential contribution of DNA glycation to genetic instability, we prepared shuttle vectors containing defined levels of the DNA glycation adduct N(2)-(1-carboxyethyl)-2'-deoxyguanosine (CEdG) and transfected them into isogenic human fibroblasts that differed solely in the capacity to conduct nucleotide excision repair (NER). In the NER-compromised fibroblasts, the induced mutation frequencies increased up to 18-fold relative to background over a range of ∼10-1400 CEdG adducts/10(5) dG, whereas the same substrates transfected into NER-competent cells induced a response that was 5-fold over background at the highest adduct density. The positive linear correlation (R(2) = 0.998) of mutation frequency with increasing CEdG level in NER-defective cells suggested that NER was the primary if not exclusive mechanism for repair of this adduct in human fibroblasts. Consistent with predictions from biochemical studies using CEdG-substituted oligonucleotides, guanine transversions were the predominant mutation resulting from replication of MG-modified plasmids. At high CEdG levels, significant increases in the number of AT → GC transitions were observed exclusively in NER-competent cells (P < 0.0001). This suggested the involvement of an NER-dependent mutagenic process in response to critical levels of DNA damage, possibly mediated by error-prone Y-family polymerases.

The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans.

PubMed

Wang, Yun; Wang, Shunchang; Luo, Xun; Yang, Yanan; Jian, Fenglei; Wang, Xuemin; Xie, Lucheng

2014-08-01

The induction of apoptosis is recognized to be a major mechanism of tributyltin (TBT) toxicity. However, the underlying signaling pathways for TBT-induced apoptosis remain unclear. In this study, using the nematode Caenorhabditis elegans, we examined whether DNA damage response (DDR) pathway and mitogen-activated protein kinase (MAPK) signaling cascades are involved in TBT-induced germline apoptosis and cell cycle arrest. Our results demonstrated that exposing worms to TBT at the dose of 10nM for 6h significantly increased germline apoptosis in N2 strain. Germline apoptosis was absent in strains that carried ced-3 or ced-4 loss-of-function alleles, indicating that both caspase protein CED-3 and Apaf-1 protein CED-4 were required for TBT-induced apoptosis. TBT-induced apoptosis was blocked in the Bcl-2 gain-of-function strain ced-9(n1950), whereas TBT induced a minor increase in the BH3-only protein EGL-1 mutated strain egl-1(n1084n3082). Checkpoint proteins HUS-1 and CLK-2 exerted proapoptotic effects, and the null mutation of cep-1, the homologue of tumor suppressor gene p53, significantly inhibited TBT-induced apoptosis. Apoptosis in the loss-of-function strains of ERK, JNK and p38 MAPK signaling pathways were completely or mildly suppressed under TBT stress. These results were supported by the results of mRNA expression levels of corresponding genes. The present study indicated that TBT-induced apoptosis required the core apoptotic machinery, and that DDR genes and MAPK pathways played essential roles in signaling the processes. Copyright © 2014 Elsevier Ltd. All rights reserved.

Benchmarking the ERG valve tip and MRI Interventions Smart Flow neurocatheter convection-enhanced delivery system's performance in a gel model of the brain: employing infusion protocols proposed for gene therapy for Parkinson's disease

NASA Astrophysics Data System (ADS)

Sillay, Karl; Schomberg, Dominic; Hinchman, Angelica; Kumbier, Lauren; Ross, Chris; Kubota, Ken; Brodsky, Ethan; Miranpuri, Gurwattan

2012-04-01

Convection-enhanced delivery (CED) is an advanced infusion technique used to deliver therapeutic agents into the brain. CED has shown promise in recent clinical trials. Independent verification of published parameters is warranted with benchmark testing of published parameters in applicable models such as gel phantoms, ex vivo tissue and in vivo non-human animal models to effectively inform planned and future clinical therapies. In the current study, specific performance characteristics of two CED infusion catheter systems, such as backflow, infusion cloud morphology, volume of distribution (mm3) versus the infused volume (mm3) (Vd/Vi) ratios, rate of infusion (µl min-1) and pressure (mmHg), were examined to ensure published performance standards for the ERG valve-tip (VT) catheter. We tested the hypothesis that the ERG VT catheter with an infusion protocol of a steady 1 µl min-1 functionality is comparable to the newly FDA approved MRI Interventions Smart Flow (SF) catheter with the UCSF infusion protocol in an agarose gel model. In the gel phantom models, no significant difference was found in performance parameters between the VT and SF catheter. We report, for the first time, such benchmark characteristics in CED between these two otherwise similar single-end port VT with stylet and end-port non-stylet infusion systems. Results of the current study in agarose gel models suggest that the performance of the VT catheter is comparable to the SF catheter and warrants further investigation as a tool in the armamentarium of CED techniques for eventual clinical use and application.

Medium-resolution échelle spectroscopy of the Red Square Nebula, MWC 922

NASA Astrophysics Data System (ADS)

Wehres, N.; Ochsendorf, B. B.; Tielens, A. G. G. M.; Cox, N. L. J.; Kaper, L.; Bally, J.; Snow, T. P.

2017-05-01

Context. Medium-resolution échelle spectra of the Red Square Nebula surrounding the star MWC 922 are presented. The spectra have been obtained in 2010 and 2012 using the X-shooter spectrograph mounted on the Very Large Telescope (VLT) in Paranal, Chile. The spectrum covers a wavelength range between 300 nm-2.5 μm and shows that the nebula is rich in emission lines. Aims: We aim to identify the emission lines and use them as a tool to determine the physical and chemical characteristics of the nebula. The emission lines are also used to put constraints on the structure of the nebula and on the nature of the central stars. Methods: We analyzed and identified emission lines that indicated that the Red Square Nebula consists of a low density bipolar outflow, eminent in the broad emission component seen in [Fe II], as well as in P Cygni line profiles indicative of fast outflowing material. The narrow component in the [Fe II] lines is most likely formed in the photosphere of a surrounding disk. Some of the emission lines show a pronounced double peaked profile, such as Ca II, indicating an accretion disk in Keplerian rotation around the central star. [O I] emission lines are formed in the neutral atomic zone separating the ionized disk photosphere from the molecular gas in the interior of the disk, which is prominent in molecular CO emission in the near-IR. [N II] and [S II] emission clearly originates in a low density but fairly hot (7 000-10 000 K) nebular environment. H I recombination lines trace the extended nebula as well as the photosphere of the disk. Results: These findings put constraints on the evolution of the central objects in MWC 922. The Red Square shows strong similarities to the Red Rectangle Nebula, both in morphology and in its mid-IR spectroscopic characteristics. As for the Red Rectangle, the observed morphology of the nebula reflects mass-loss in a binary system. Specifically, we attribute the biconical morphology and the associated rung-like structure to the action of intermittent jets blown by the accreting companion in a dense shell, which has been created by the primary. We stress, though, that despite the morphological similarities, these two objects represent very different classes of stellar objects. The data-reduced spectra are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A69

NICMOS PEERS THROUGH DUST TO REVEAL YOUNG STELLAR DISKS

NASA Technical Reports Server (NTRS)

2002-01-01

The following images were taken by NASA Hubble Space Telescope's Near-Infrared Camera and Multi-Object Spectrometer (NICMOS). All of the objects are extremely young stars, 450 light-years away in the constellation Taurus. Most of the nebulae represent small dust particles around the stars, which are seen because they are reflecting starlight. In the color-coding, regions of greatest dust concentration appear red. All photo credits: D. Padgett (IPAC/Caltech), W. Brandner (IPAC), K. Stapelfeldt (JPL) and NASA [Top left]: CoKu Tau/1. This image shows a newborn binary star system, CoKu Tau/1, lying at the center of four 'wings' of light extending as much as 75 billion miles from the pair. The 'wings' outline the edges of a region in the stars' dusty surroundings, which have been cleared by outflowing gas. A thin, dark lane extends to the left and to right of the binary, suggesting that a disk or ring of dusty material encircles the two young stars. [Top center]: DG Tau B - An excellent example of the complementary nature of Hubble's instruments may be found by comparing the infrared NICMOS image of DG Tau B to the visible-light Wide Field and Planetary Camera 2 (WFPC2) image of the same object. WFPC2 highlights the jet emerging from the system, while NICMOS penetrates some of the dust near the star to more clearly outline the 50 billion-mile-long dust lane (the horizontal dark band, which indicates the presence of a large disk forming around the infant star). The young star itself appears as the bright red spot at the corner of the V-shaped nebula. [Top right]: Haro 6-5B - This image of the young star Haro 6-5B shows two bright regions separated by a dark lane. As seen in the WFPC2 image of the same object, the bright regions represent starlight reflecting from the upper and lower surfaces of the disk, which is thicker at its edges than its center. However, the infrared view reveals the young star just above the dust lane. [Bottom left]: I04016 - A very young star still deep within the dusty cocoon from which it formed is shown in this image of IRAS 04016+2610. The star is visible as a bright reddish spot at the base of a bowl-shaped nebula about 100 billion miles across at the widest point. The nebula arises from dusty material falling onto a forming circumstellar disk, seen as a partial dark band to the left of the star. The necklace of bright spots above the star is an image artifact. [Bottom center]: I04248 - In this image of IRAS 04248+2612, the infrared eyes of NICMOS peer through a dusty cloud to reveal a double-star system in formation. A nebula extends at least 65 billion miles in opposite directions from the twin stars, and is illuminated by them. This nebula was formed from material ejected by the young star system. The apparent 'pinching' of this nebula close to the binary suggests that a ring or disk of dust and gas surrounds the two stars. [Bottom right]: I04302 - This image shows IRAS 04302+2247, a star hidden from direct view and seen only by the nebula it illuminates. Dividing the nebula in two is a dense, edge-on disk of dust and gas which appears as the thick, dark band crossing the center of the image. The disk has a diameter of 80 billion miles (15 times the diameter of Neptune's orbit), and has a mass comparable to the Solar Nebula, which gave birth to our planetary system. Dark clouds and bright wisps above and below the disk suggest that it is still building up from infalling dust and gas.

Development and application of air quality models at the US ...

EPA Pesticide Factsheets

Overview of the development and application of air quality models at the U.S. EPA, particularly focused on the development and application of the Community Multiscale Air Quality (CMAQ) model developed within the Computation Exposure Division (CED) of the National Exposure Research Laboratory (NERL). This presentation will provide a simple overview of air quality model development and application geared toward a non-technical student audience. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies

PubMed Central

Kim, Jung Hwan; Astary, Garrett W.; Kantorovich, Svetlana; Mareci, Thomas H.; Carney, Paul R.; Sarntinoranont, Malisa

2012-01-01

Convection-enhanced delivery (CED) is a promising local delivery technique for overcoming the blood–brain barrier (BBB) and treating diseases of the central nervous system (CNS). For CED, therapeutics are infused directly into brain tissue and the drug agent is spread through the extracellular space, considered to be highly tortuous porous media. In this study, 3D computational models developed using magnetic resonance (MR) diffusion tensor imaging data sets were used to predict CED transport in the rat ventral hippocampus using a voxelized modeling previously developed by our group. Predicted albumin tracer distributions were compared with MR-measured distributions from in vivo CED in the ventral hippocampus up to 10 μL of Gd-DTPA albumin tracer infusion. Predicted and measured tissue distribution volumes and distribution patterns after 5 and 10 μL infusions were found to be comparable. Tracers were found to occupy the underlying landmark structures with preferential transport found in regions with less fluid resistance such as the molecular layer of the dentate gyrus. Also, tracer spread was bounded by high fluid resistance layers such as the granular cell layer and pyramidal cell layer of dentate gyrus. Leakage of tracers into adjacent CSF spaces was observed towards the end of infusions. PMID:22532321

Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings.

PubMed

Niemela, Julie; Kuehn, Hye Sun; Kelly, Corin; Zhang, Mingchang; Davies, Joie; Melendez, Jose; Dreiling, Jennifer; Kleiner, David; Calvo, Katherine; Oliveira, João B; Rosenzweig, Sergio D

2015-05-01

Caspase-8 deficiency (CED) was originally described in 2002 in two pediatric patients presenting with clinical manifestations resembling autoimmune lymphoproliferative syndrome (ALPS) accompanied by infections, and T, B and NK cell defects. Since then, no new CED patients were published. Here we report two adult siblings (Pt1 and Pt2) presenting in their late thirties with pulmonary hypertension leading to lung transplant (Pt1), and a complex neurological disease leading to multiple cranial nerves palsies (Pt2) as their main manifestations. A thorough clinical and immunological evaluation was performed at the Primary Immunodeficiency Clinic at NIH, followed by whole exome sequencing. The patients had multiorgan lymphocytic infiltration and granulomas, as well as clinical signs of immune deficiency/ immune dysregulation. Both siblings carried homozygous mutations in CASP8, c.1096C > T, p.248R > W. This was the same mutation described on the previously published CED patients, to whom these new patients were likely distantly related. We report two new CED patients presenting during adulthood with life-threatening end-organ lymphocyte infiltrates affecting the lungs, liver, spleen, bone marrow and central nervous system. This phenotype broadens the clinical spectrum of manifestations associated with this disease and warrants the search of CASP8 mutations in other cohorts of patients.

Determinants of Cancer Early Detection Behaviors:Application of Protection Motivation Theory.

PubMed

Rahaei, Zohreh; Ghofranipour, Fazlollah; Morowatisharifabad, Mohammad Ali; Mohammadi, Eesa

2015-01-01

Cancer is account for 13% of all deaths around the world and is the third cause of mortality in Iran. More than one third of these cases are pre-ventable and about 33% are curable with early detection. The aim of this study was to determine the predictors of cancer early detection (CED) behaviors applying Protection Motivation Theory (PMT). In this cross-sectional study, cluster sampling method was employed to recruit 260 individuals of above 20 years old in Yazd, Iran and a researcher designed questionnaire was completed through interviews for each of the respondents. PMT theoretical variables and CED behaviors were the basis of data collection procedure. Participants acquired 64.47% of the protection motivation, 30.97% of the passive and 45.64% of the active behaviors‟ possible scores. Theory constructs predicted 19.8%, 15.6% and 9.6% of the variations for protection motivation, passive and active behavior respectively. Protection motivation was responsible for 3.6% of passive and 8% of active behaviors‟ variations. Considering the scarceness of CED behaviors and the applicability of PMT in predicting these behaviors, utilization of the PMT‟s constructs in any interventional programs to accelerate CED behaviors could be an alternate methodological choice in the cancer control initiatives.

Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors.

PubMed

Saucier-Sawyer, Jennifer K; Seo, Young-Eun; Gaudin, Alice; Quijano, Elias; Song, Eric; Sawyer, Andrew J; Deng, Yang; Huttner, Anita; Saltzman, W Mark

2016-06-28

Glioblastoma multiforme (GBM) is a fatal brain tumor characterized by infiltration beyond the margins of the main tumor mass and local recurrence after surgery. The blood-brain barrier (BBB) poses the most significant hurdle to brain tumor treatment. Convection-enhanced delivery (CED) allows for local administration of agents, overcoming the restrictions of the BBB. Recently, polymer nanoparticles have been demonstrated to penetrate readily through the healthy brain when delivered by CED, and size has been shown to be a critical factor for nanoparticle penetration. Because these brain-penetrating nanoparticles (BPNPs) have high potential for treatment of intracranial tumors since they offer the potential for cell targeting and controlled drug release after administration, here we investigated the intratumoral CED infusions of PLGA BPNPs in animals bearing either U87 or RG2 intracranial tumors. We demonstrate that the overall volume of distribution of these BPNPs was similar to that observed in healthy brains; however, the presence of tumors resulted in asymmetric and heterogeneous distribution patterns, with substantial leakage into the peritumoral tissue. Together, our results suggest that CED of BPNPs should be optimized by accounting for tumor geometry, in terms of location, size and presence of necrotic regions, to determine the ideal infusion site and parameters for individual tumors. Copyright © 2016 Elsevier B.V. All rights reserved.

Time-reversal Techniques in Ultrasound-assisted Convection-enhanced Drug Delivery to the Brain: Technology Development and In Vivo Evaluation

PubMed Central

Lewis, George K.; Guarino, Sabrina; Gandhi, Gaurav; Filinger, Laurent; Lewis, George K.; Olbricht, Willam L.; Sarvazyan, Armen

2011-01-01

We describe a drug delivery method that combines Time-Reversal Acoustics (TRA) with Convection-Enhanced Delivery (CED) to improve the delivery of therapeutics to the interstitium of the brain. The Ultrasound-assisted CED approach (UCED) circumvents the blood-brain barrier by infusing compounds through a cannula that is inserted into the brain while simultaneously delivering ultrasound to improve the penetration of pharmaceuticals. CED without ultrasound-assistance has been used to treat a variety of neural disorders, including glioblastoma multiforme, a malignancy that presents a very poor prognosis for patients. We describe a novel system that is used to infuse fluids into the brain parenchyma while simultaneously exposing the tissue to safe levels of 1-MHz, low intensity, ultrasound energy. The system includes a combined infusion needle-hydrophone, a 10-channel ultralow-output impedance amplifier, a broad-band ultrasound resonator, and MatLab®-based TRA control and user-interface. TRA allows easy coupling of ultrasound therapy through the skull without complex phase-correction and array design. The smart targeting UCED system has been tested in vivo and results show it provides 1.5-mm spatial resolution for UCED and improves tracer distribution in the brain over CED alone. PMID:21881622

Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex.

PubMed

Foley, Conor P; Nishimura, Nozomi; Neeves, Keith B; Schaffer, Chris B; Olbricht, William L

2012-02-01

Convection-enhanced delivery (CED) is a promising technique for administering large therapeutics that do not readily cross the blood brain barrier to neural tissue. It is of vital importance to understand how large drug constructs move through neural tissue during CED to optimize construct and delivery parameters so that drugs are concentrated in the targeted tissue, with minimal leakage outside the targeted zone. Experiments have shown that liposomes, viral vectors, high molecular weight tracers, and nanoparticles infused into neural tissue localize in the perivascular spaces of blood vessels within the brain parenchyma. In this work, we used two-photon excited fluorescence microscopy to monitor the real-time distribution of nanoparticles infused in the cortex of live, anesthetized rats via CED. Fluorescent nanoparticles of 24 and 100 nm nominal diameters were infused into rat cortex through microfluidic probes. We found that perivascular spaces provide a high permeability path for rapid convective transport of large nanoparticles through tissue, and that the effects of perivascular spaces on transport are more significant for larger particles that undergo hindered transport through the extracellular matrix. This suggests that the vascular topology of the target tissue volume must be considered when delivering large therapeutic constructs via CED.

Meteoritic Constraints on Models of the Solar Nebula: The Abundances of Moderately Volatile Elements

NASA Technical Reports Server (NTRS)

Cassen, Patrick; Cuzzi, Jeff (Technical Monitor)

1994-01-01

The "moderately volatile" elements are those which condense (or evaporate) in the temperature range 650 - 1350 K, as a mix of material with solar abundances is cooled (or heated) tinder equilibrium conditions. Their relative abundances in chondritic meteorites are solar (or "cosmic", as defined by the composition of Cl meteorites) to within a factor of several, but vary within that range in a way that correlates remarkably well with condensation temperature, independent of chemical affinity. It has been argued that this correlation reflects a systematically selective process which favored the accretion of refractory material over volatile material from a cooling nebula. Wasson and Chou (Meteoritics 9, 69-94, 1974, and Wasson and co-authors in subsequent papers) suggested that condensation and settling of solids contemporaneously with the cooling and removal of nebular gas could produce the observed abundance patterns, but a quantitative model has been lacking. We show that the abundance patterns of the moderately volatile elements in chondritic meteorites can be produced, in some degree of quantitative detail, by models of the solar nebula that are designed to conform to observations of T Tauri stars and the global conservation laws. For example, even if the local surface density of the nebula is not decreasing, condensation and accretion of solids from radially inflowing gas in a cooling nebula can result in depletions of volatiles, relative to refractories, like those observed, The details of the calculated abundance patterns depend on (but are not especially sensitive to) model parameters, and can exhibit the variations that distinguish the meteorite classes. Thus it appears that nebula characteristics such as cooling rates, radial flow velocities, and particle accumulation rates can be quantitatively constrained by demanding that they conform to meteoritic data; and the models, in turn, can produce testable hypotheses regarding the time and location of the formation of the chondrite parent bodies and the planets.

Stellar Metamorphosis:

NASA Technical Reports Server (NTRS)

2002-01-01

[TOP LEFT AND RIGHT] The Hubble Space Telescope's Wide Field and Planetary Camera 2 has captured images of the birth of two planetary nebulae as they emerge from wrappings of gas and dust, like butterflies breaking out of their cocoons. These images highlight a fleeting phase in the stellar burnout process, occurring just before dying stars are transformed into planetary nebulae. The left-hand image is the Cotton Candy nebula, IRAS 17150-3224; the right-hand image, the Silkworm nebula, IRAS 17441-2411. Called proto-planetary nebulae, these dying stars have been caught in a transition phase between a red giant and a planetary nebula. This phase is only about 1,000 years long, very short in comparison to the 1 billion-year lifetime of a star. These images provide the earliest snapshots of the transition process. Studying images of proto-planetary nebulae is important to understanding the process of star death. A star begins to die when it has exhausted its thermonuclear fuel - hydrogen and helium. The star then becomes bright and cool (red giant phase) and swells to several tens of times its normal size. It begins puffing thin shells of gas off into space. These shells become the star's cocoon. In the Hubble images, the shells are the concentric rings seen around each nebula. But the images also reveal the nebulae breaking out from those shells. The butterfly-like wings of gas and dust are a common shape of planetary nebulae. Such butterfly shapes are created by the 'interacting winds' process, in which a more recent 'fast wind' - material propelled by radiation from the hot central star - punches a hole in the cocoon, allowing the nebula to emerge. (This 'interacting wind' theory was first proposed by Dr. Sun Kwok to explain the origin of planetary nebulae, and has been subsequently proven successful in explaining their shapes.) The nebulae are being illuminated by light from the invisible central star, which is then reflected toward us. We are viewing the nebulae edge-on, where the direct starlight is blocked by the dusty cocoon. Otherwise, the starlight would overwhelm the nebular light, making it very difficult to see the butterfly-shaped nebula. In a few hundred years, intense ultraviolet radiation from the central star will energize the surrounding gas, causing it to glow brightly, and a planetary nebula is born. These observations were made with the Wide Field and Planetary Camera 2 using three filters: yellow-green, blue, and near-infrared. The images were taken in 1997 by Sun Kwok and in 1996 by Matt Bobrowsky. Credits: Sun Kwok and Kate Su (University of Calgary), Bruce Hrivnak (Valparaiso University), and NASA ----------------- The Hubble Space Telescope Sees Remarkable Structure in the Heart of a Planetary Nebula [BOTTOM LEFT AND RIGHT] This Wide Field and Planetary Camera 2 image of NGC 6818 shows two distinct layers of gas (with dust): a spherical outer region and a brighter, vase-shaped interior 'bubble.' Astronomers believe that a fast wind - material propelled by radiation from the hot central star - is creating the inner elongated shape. The central star of the planetary nebula appears as a tiny blue dot. The material in the wind is traveling so fast that it smashes through older, slower-moving stellar debris, causing a 'blowout' at both ends of the bubble (lower right and upper left). This nebula looks like a twin of NGC 3918, another planetary nebula that has been observed by the Hubble telescope. The structure of NGC 3918 is remarkably similar to that of NGC 6818. It has an outer spherical envelope and an inner, brighter, elongated bubble. A fast-moving wind also appears to have created an orifice at one end (bottom right-hand corner) of the inner bubble. There are even faint wisps of material that were probably blown out of this hole. In the opposite direction (top left-hand corner), there is a protrusion that seems on the verge of breaking through to form a hole. By finding and studying such similar objects, astronomers hope to learn crucial details about the evolutionary history of planetary nebulae. The Hubble telescope observation was taken March 10, 1997. This picture is a composite of images taken with three filters that are representative of the true colors of the object. Two of these are, respectively, in the light of a red and a blue spectral line of hydrogen - the major constituent of the nebula. The third image is in the light of a luminous green line due to doubly ionized oxygen. NGC 6818 is about 6,000 light-years away in the constellation Sagittarius. The nebula has a diameter of about 0.5 light-years. Credits: Robert Rubin (NASA Ames Research Center), Reginald Dufour and Matt Browning (Rice University), Patrick Harrington (University of Maryland), and NASA

Spacelab

NASA Image and Video Library

1989-01-01

In 1986, NASA introduced a Shuttle-borne ultraviolet observatory called Astro. The Astro Observatory was designed to explore the universe by observing and measuring the ultraviolet radiation from celestial objects. Astronomical targets of observation selected for Astro missions included planets, stars, star clusters, galaxies, clusters of galaxies, quasars, remnants of exploded stars (supernovae), clouds of gas and dust (nebulae), and the interstellar medium. Astro-1 used a Spacelab pallet system with an instrument pointing system and a cruciform structure for bearing the three ultraviolet instruments mounted in a parallel configuration. The three instruments were: The Hopkins Ultraviolet Telescope (HUT), which was designed to obtain far-ultraviolet spectroscopic data from white dwarfs, emission nebulae, active galaxies, and quasars; the Wisconsin Ultraviolet Photo-Polarimeter Experiment (WUPPE) which was to study polarized ultraviolet light from magnetic white dwarfs, binary stars, reflection nebulae, and active galaxies; and the Ultraviolet Imaging Telescope (UIT) which was to record photographic images in ultraviolet light of galaxies, star clusters, and nebulae. The star trackers that supported the instrument pointing system were also mounted on the cruciform. Also in the payload bay was the Broad Band X-Ray Telescope (BBXRT), which was designed to obtain high-resolution x-ray spectra from stellar corona, x-ray binary stars, active galactic nuclei, and galaxy clusters. Managed by the Marshall Space Flight Center, the Astro-1 observatory was launched aboard the Space Shuttle Orbiter Columbia (STS-35) on December 2, 1990.

The solar nebula redox state as recorded by the most reduced chondrules of five primitive chondrites

NASA Technical Reports Server (NTRS)

Johnson, M. C.

1986-01-01

Mafic minerals in the most reduced chondrules of five primitive meteorites were analyzed with an electron microprobe to determine the lower limit on their FeO contents. The accuracy obtained was + or - 0.01 weight percent FeO. The thermodynamic relationship between mole fraction FeSiO3 and pO2 of the ambient nebular gas at the time of mineral equilibration was established, and was used to infer the local O/H ratio of the nebular gas during chondrule formation. The lowest ferrosilite compositions reflected equilibration at 1500 K with a gas 2-18 times more oxidizing than a gas of solar composition. Olivines in low-FeO unequilibrated ordinary chondrites (UOC) chondrules are uniformly more FeO-rich than coexisting pyroxenes. This discrepancy suggests that a significant change in the O/H ratio of the nebular gas occurred between the time of olivine and pyroxene crystallization in the region of the nebula where UOCs formed. Mineral compositions in the chondrules of two C2 chondrites studied suggest they formed in a more homogeneous region of the nebula than the UOCs.

Hearing loss: terminology and classification. Joint Committee of the American Speech-Language-Hearing Association and the Council on Education of the Deaf.

PubMed

1998-01-01

The following position statement and technical report were developed by the Joint Committee of the American Speech-Language-Hearing Association (ASHA) and the Council on Education of the Deaf (CED) and approved as Association policy by the ASHA Legislative Council in November 1997 (LC 6-97). CED member organizations are reviewing the document for approval in 1998. Joint Committee members responsible for the development of this document include (from ASHA) Joan Marttila, chair 1996-97; Linda Seestedt-Stanford, chair 1994-95; Evelyn Cherow, ex official; Donald Goldberg; Dawna Lewis; Leslie Ann McMillian; Jane Seaton; Alicia Stewart; and Larry Higdon, vice president for professional practices in audiology and monitoring vice president; and (from CED) Kathee Christensen; Steve Nover; Marilyn Sass-Lehrer; and Patrick Stone. This document supersedes ASHA policy: Definitions of Communication Disorders and Variations: Hearing Disorders section.

The regulation of cognitive enhancement devices: extending the medical model

PubMed Central

Maslen, Hannah; Douglas, Thomas; Cohen Kadosh, Roi; Levy, Neil; Savulescu, Julian

2014-01-01

This article presents a model for regulating cognitive enhancement devices (CEDs). Recently, it has become very easy for individuals to purchase devices which directly modulate brain function. For example, transcranial direct current stimulators are increasingly being produced and marketed online as devices for cognitive enhancement. Despite posing risks in a similar way to medical devices, devices that do not make any therapeutic claims do not have to meet anything more than basic product safety standards. We present the case for extending existing medical device legislation to cover CEDs. Medical devices and CEDs operate by the same or similar mechanisms and pose the same or similar risks. This fact coupled with the arbitrariness of the line between treatment and enhancement count in favour of regulating these devices in the same way. In arguing for this regulatory model, the paper highlights potential challenges to its implementation, and suggests solutions. PMID:25243073

POLYCYCLIC AROMATIC HYDROCARBONS WITH STRAIGHT EDGES AND THE 7.6/6.2 AND 8.6/6.2 INTENSITY RATIOS IN REFLECTION NEBULAE.

PubMed

Ricca, Alessandra; Bauschlicher, Charles W; Roser, Joseph E; Peeters, Els

2018-01-01

We have investigated the mid-infrared spectral characteristics of a series of polycyclic aromatic hydrocarbons (PAHs) with straight edges and containing an even or odd number of carbons using density functional theory (DFT). For several even and odd-carbon PAHs, the 8.6/6.2 and 7.6/6.2 intensity ratios computed in emission after the absorption of a 8 eV photon match the observed ratios obtained for three reflection nebulae (RNe), namely NGC 1333, NGC 7023, and NGC 2023. Odd-carbon PAHs are favored, particularly for NGC 1333. Both cations and anions are present with the cations being predominant. Relevant PAHs span sizes ranging from 46 to 103-113 carbons for NGC 7023 and NGC 2023 and from 38 to 127 carbons for NGC 1333 and have symmetries ranging from D 2 h to C s . Our work suggests that even and odd-carbon PAHs with straight edges are viable candidates for the PAH emission seen towards irradiated Photo-Dissociation Regions (PDRs).

Polycyclic Aromatic Hydrocarbons with Straight Edges and the 7.6/6.2 and 8.6/6.2 Intensity Ratios in Reflection Nebulae

NASA Astrophysics Data System (ADS)

Ricca, Alessandra; Bauschlicher, Charles W., Jr.; Roser, Joseph E.; Peeters, Els

2018-02-01

Using density functional theory, we have investigated the mid-infrared spectral characteristics of a series of polycyclic aromatic hydrocarbons (PAHs) that have straight edges and that contain an even or odd number of carbons. For several even and odd-carbon PAHs, the 8.6/6.2 and 7.6/6.2 intensity ratios computed in emission after the absorption of a 8 eV photon match the observed ratios obtained for three reflection nebulae (RNe), namely NGC 1333, NGC 7023, and NGC 2023. Odd-carbon PAHs are favored, particularly for NGC 1333. Both cations and anions are present, with the cations being predominant. Relevant PAHs span sizes ranging from 46 to 113 carbons for NGC 7023 and NGC 2023 and from 38 to 127 carbons for NGC 1333, and have symmetries ranging from D2h to C s . Our work suggests that even- and odd-carbon PAHs with straight edges are viable candidates for the PAH emission seen toward irradiated photodissociation regions.

Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors

PubMed Central

Yang, Weilian; Wu, Gong; Huo, Tianyao; Tjarks, Werner; Ciesielski, Michael; Fenstermaker, Robert A.; Ross, Brain D.; Wikstrand, Carol J.; Riley, Kent J.; Binns, Peter J.

2010-01-01

In the present study, we have evaluated a boronated dendrimer-epidermal growth factor (BD-EGF) bioconjugate as a molecular targeting agent for boron neutron capture therapy (BNCT) of the human EGFR gene-transfected F98 rat glioma, designated F98EGFR. EGF was chemically linked to a heavily boronated polyamidoamine dendrimer (BD) by means of the heterobifunctional reagent, mMBS. Biodistribution studies were carried out at 6 h and 24 h following intratumoral (i.t.) injection or intracerebral (i.c.) convection enhanced delivery (CED) of 125I-labeled or unlabeled BD-EGF (40 μg 10B/10 μg EGF) to F98 glioma bearing rats. At 24 h. there was 43% more radioactivity in EGFR(+) tumors following CED compared to i.t. injection, and a doubling of the tumor boron concentration (22.3 μg/g vs. 11.7 μg/g). CED of BD-EGF resulted in a 7.2× increase in the volume of distribution within the infused cerebral hemisphere and a 1.9× increase in tumor uptake of BD-EGF compared with i.t. injection. Based on these favorable bio-distribution data, BNCT was carried out at the Massachusetts Institute of Technology nuclear reactor 14 days following i.c. tumor implantation and 24 h. after CED of BD-EGF. These animals had a MST of 54.1 ± 4.7 days compared to 43.0 ± 2.8 days following i.t. injection. Rats that received BD-EGF by CED in combination with i.v. boronophenylalanine (BPA), which has been used in both experimental and clinical studies, had a MST of 86.0 ± 28.1 days compared to 39.8 ± 1.6 days for i.v. BPA alone (P < 0.01), 30.9 ± 1.4 days for irradiated controls and 25.1 ± 1.0 days for untreated controls (overall P < 0.0001). These data have demonstrated that the efficacy of BNCT was significantly increased (P < 0.006), following i.c CED of BD-EGF compared to i.t injection, and that the survival data were equivalent to those previously reported by us using the boronated anti-human-EGF mAb, C225 (cetuximab). PMID:19588228

Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma.

PubMed

Sewing, A Charlotte P; Lagerweij, Tonny; van Vuurden, Dannis G; Meel, Michaël H; Veringa, Susanna J E; Carcaboso, Angel M; Gaillard, Pieter J; Peter Vandertop, W; Wesseling, Pieter; Noske, David; Kaspers, Gertjan J L; Hulleman, Esther

2017-05-01

OBJECTIVE Pediatric high-grade gliomas (pHGGs) including diffuse intrinsic pontine gliomas (DIPGs) are primary brain tumors with high mortality and morbidity. Because of their poor brain penetrance, systemic chemotherapy regimens have failed to deliver satisfactory results; however, convection-enhanced delivery (CED) may be an alternative mode of drug delivery. Anthracyclines are potent chemotherapeutics that have been successfully delivered via CED in preclinical supratentorial glioma models. This study aims to assess the potency of anthracyclines against DIPG and pHGG cell lines in vitro and to evaluate the efficacy of CED with anthracyclines in orthotopic pontine and thalamic tumor models. METHODS The sensitivity of primary pHGG cell lines to a range of anthracyclines was tested in vitro. Preclinical CED of free doxorubicin and pegylated liposomal doxorubicin (PLD) to the brainstem and thalamus of naïve nude mice was performed. The maximum tolerated dose (MTD) was determined based on the observation of clinical symptoms, and brains were analyzed after H & E staining. Efficacy of the MTD was tested in adult glioma E98-FM-DIPG and E98-FM-thalamus models and in the HSJD-DIPG-007-Fluc primary DIPG model. RESULTS Both pHGG and DIPG cells were sensitive to anthracyclines in vitro. Doxorubicin was selected for further preclinical evaluation. Convection-enhanced delivery of the MTD of free doxorubicin and PLD in the pons was 0.02 mg/ml, and the dose tolerated in the thalamus was 10 times higher (0.2 mg/ml). Free doxorubicin or PLD via CED was ineffective against E98-FM-DIPG or HSJD-DIPG-007-Fluc in the brainstem; however, when applied in the thalamus, 0.2 mg/ml of PLD slowed down tumor growth and increased survival in a subset of animals with small tumors. CONCLUSIONS Local delivery of doxorubicin to the brainstem causes severe toxicity, even at doxorubicin concentrations that are safe in the thalamus. As a consequence, the authors could not establish a therapeutic window for treating orthotopic brainstem tumors in mice. For tumors in the thalamus, therapeutic concentrations to slow down tumor growth could be reached. These data suggest that anatomical location determines the severity of toxicity after local delivery of therapeutic agents and that caution should be used when translating data from supratentorial CED studies to treat infratentorial tumors.

Development of a portable quality control application using a tablet-type electronic device.

PubMed

Ono, Tomohiro; Miyabe, Yuki; Akimoto, Mami; Mukumoto, Nobutaka; Ishihara, Yoshitomo; Nakamura, Mitsuhiro; Mizowaki, Takashi

2018-03-01

Our aim was to develop a portable quality control (QC) application using a thermometer, a barometer, an angle gauge, and a range finder implemented in a tablet-type consumer electronic device (CED) and to assess the accuracies of the measurements made. The QC application was programmed using Java and OpenCV libraries. First, temperature and atmospheric pressure were measured over 30 days using the temperature and pressure sensors of the CED and compared with those measured by a double-tube thermometer and a digital barometer. Second, the angle gauge was developed using the accelerometer of the CED. The roll and pitch angles of the CED were measured from 0 to 90° at intervals of 10° in the clockwise (CW) and counterclockwise (CCW) directions. The values were compared with those measured by a digital angle gauge. Third, a range finder was developed using the tablet's built-in camera and image-processing capacities. Surrogate markers were detected by the camera and their positions converted to actual positions using a homographic transformation method. Fiducial markers were placed on a treatment couch and moved 100 mm in 10-mm steps in both the lateral and longitudinal directions. The values were compared with those measured by the digital output of the treatment couch. The differences between CED values and those of other devices were compared by calculating means ± standard deviations (SDs). The means ± SDs of differences in temperature and atmospheric pressure were -0.07 ± 0.25°C and 0.05 ± 0.10 hPa, respectively. The means ± SDs of the difference in angle was -0.17 ± 0.87° (0.15 ± 0.23° degrees excluding the 90° angle). The means ± SDs of distances were 0.01 ± 0.07 mm in both the lateral and longitudinal directions. Our portable QC application was accurate and may be used instead of standard measuring devices. Our portable CED is efficient and simple when used in the field of medical physics. © 2018 American Association of Physicists in Medicine.

Market Access Agreements for pharmaceuticals in Europe: diversity of approaches and underlying concepts.

PubMed

Jarosławski, Szymon; Toumi, Mondher

2011-10-08

Market Access Agreements (MAA) between pharmaceutical industry and health care payers have been proliferating in Europe in the last years. MAA can be simple discounts from the list price or very sophisticated schemes with inarguably high administrative burden. We distinguished and defined from the health care payer perspective three kinds of MAA: Commercial Agreements (CA), Payment for Performance Agreements (P4P) and Coverage with Evidence Development (CED). Apart from CA, the agreements assumed collection and analysis of real-life health outcomes data, either from a cohort of patients (CED) or on per patient basis (P4P). We argue that while P4P aim at reducing drug cost to payers without a systematic approach to addressing uncertainty about drugs' value, CED were implemented provisionally to reduce payer's uncertainty about value of a medicine within a defined time period. We are of opinion that while CA and P4P have a potential to reduce payers' expenditure on costly drugs while maintaining a high list price, CED address initial uncertainty related to assessing the real-life value of new drugs and enable a final HTA recommendation or reimbursement and pricing decisions. Further, we suggest that real cost to health care payers of drugs in CA and P4P should be made publicly available in a systematic manner, to avoid a perverse impact of these MAA types on the international reference pricing system.

Expression of animal anti-apoptotic gene Ced-9 enhances tolerance during Glycine max L.-Bradyrhizobium japonicum interaction under saline stress but reduces nodule formation.

PubMed

Robert, Germán; Muñoz, Nacira; Melchiorre, Mariana; Sánchez, Federico; Lascano, Ramiro

2014-01-01

The mechanisms by which the expression of animal cell death suppressors in economically important plants conferred enhanced stress tolerance are not fully understood. In the present work, the effect of expression of animal antiapoptotic gene Ced-9 in soybean hairy roots was evaluated under root hairs and hairy roots death-inducing stress conditions given by i) Bradyrhizobium japonicum inoculation in presence of 50 mM NaCl, and ii) severe salt stress (150 mM NaCl), for 30 min and 3 h, respectively. We have determined that root hairs death induced by inoculation in presence of 50 mM NaCl showed characteristics of ordered process, with increased ROS generation, MDA and ATP levels, whereas the cell death induced by 150 mM NaCl treatment showed non-ordered or necrotic-like characteristics. The expression of Ced-9 inhibited or at least delayed root hairs death under these treatments. Hairy roots expressing Ced-9 had better homeostasis maintenance, preventing potassium release; increasing the ATP levels and controlling the oxidative damage avoiding the increase of reactive oxygen species production. Even when our results demonstrate a positive effect of animal cell death suppressors in plant cell ionic and redox homeostasis under cell death-inducing conditions, its expression, contrary to expectations, drastically inhibited nodule formation even under control conditions.

The Plant Cuticle Is Required for Osmotic Stress Regulation of Abscisic Acid Biosynthesis and Osmotic Stress Tolerance in Arabidopsis[W

PubMed Central

Wang, Zhen-Yu; Xiong, Liming; Li, Wenbo; Zhu, Jian-Kang; Zhu, Jianhua

2011-01-01

Osmotic stress activates the biosynthesis of abscisic acid (ABA). One major step in ABA biosynthesis is the carotenoid cleavage catalyzed by a 9-cis epoxycarotenoid dioxygenase (NCED). To understand the mechanism for osmotic stress activation of ABA biosynthesis, we screened for Arabidopsis thaliana mutants that failed to induce the NCED3 gene expression in response to osmotic stress treatments. The ced1 (for 9-cis epoxycarotenoid dioxygenase defective 1) mutant isolated in this study showed markedly reduced expression of NCED3 in response to osmotic stress (polyethylene glycol) treatments compared with the wild type. Other ABA biosynthesis genes are also greatly reduced in ced1 under osmotic stress. ced1 mutant plants are very sensitive to even mild osmotic stress. Map-based cloning revealed unexpectedly that CED1 encodes a putative α/β hydrolase domain-containing protein and is allelic to the BODYGUARD gene that was recently shown to be essential for cuticle biogenesis. Further studies discovered that other cutin biosynthesis mutants are also impaired in osmotic stress induction of ABA biosynthesis genes and are sensitive to osmotic stress. Our work demonstrates that the cuticle functions not merely as a physical barrier to minimize water loss but also mediates osmotic stress signaling and tolerance by regulating ABA biosynthesis and signaling. PMID:21610183

The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suzuki, Emiko; Nakayama, Manabu

2007-07-01

Ced-1 protein is a Caenorhabditis elegans cell surface receptor involved in phagocytosis of dead cells. The gene encoding the mammalian ortholog of Ced-1 is yet to be identified. Here, we describe a potential candidate: human MEGF10. MEGF10 has the overall domain organization of Ced-1, containing a signal peptide, a EMI domain, 17 atypical EGF-like repeats, a transmembrane domain, and a cytoplasmic domain with NPXY and YXXL motifs. MEGF10-EGFP fusion protein expressed in HEK293 cells produced an irregular, mosaic-like pattern on the surface of coated glass. Protruded MEGF10 bound tightly to the glass, in effect 'pinning' the cytoplasmic membrane firmly ontomore » the glass, thereby restricting cell motility. These cells also took on a flat appearance. Although MEGF10-EGFP localized throughout the cytoplasmic membrane, no MEGF10-EGFP was found in lamellipodia. The MEGF10-EGFP signal was surrounded by a 1-2-{mu}m-wide dark strip lacking EGFP. Expression analyses of various MEGF10 deletion mutants revealed that the irregular, mosaic-like adhesion pattern characteristic of MEGF10 family members is due to concerted interactions between the EMI and 17 atypical EGF-like domains. Co-culturing of MEGF10-EGFP-expressing cells with apoptotic cells revealed that MEGF10 protein accumulated around the contact region during engulfment of apoptotic cells.« less

The Making of a Pre-Planetary Nebula

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-07-01

The gas expelled by dying stars gets twisted into intricate shapes and patterns as nebulae form. Now a team of researchers might have some answers about how this happens.Whats a Pre-Planetary Nebula?This H-R diagram for the globular cluster M5 shows where AGB stars lie: they are represented by blue markers here. The AGB is one of the final stages in a low- to intermediate-mass stars lifetime. [Lithopsian]When a low- to intermediate-mass star approaches the end of its lifetime, it moves onto the Asymptotic Giant Branch (AGB) in the Herzsprung-Russell diagram. As the star exhausts its fuel here, it shrugs off its outer layers. These layers of gas then encase the stars core, which is not yet hot enough to ionize the gas and cause it to glow.Instead, during this time the gas is relatively cool and dark, faintly reflecting light from the star and emitting only very dim infrared emission of its own. At this stage, the gas represents a pre-planetary nebula. Only later when the stellar core contracts enough to heat up and emit ionizing radiation does the nebula begin to properly glow, at which point it qualifies as a full planetary nebula.Images of OH231 in optical light (top) and 12CO (bottom) taken from the literature. [See Balick et al. 2017 for full credit]Unexpected ShapesPre-planetary nebulae are a very short-lived evolutionary stage, so weve observed only a few hundred of them which has left many unanswered questions about these objects.One particular mystery is that of their shapes: if these nebulae are formed by stars expelling their outer layers, we would naively expect them to be simple spherical shells and yet we observe pre-planetary nebulae to have intricate shapes and patterns. How does the star create these asymmetric shapes? A team of scientists led by Bruce Balick (University of Washington, Seattle) has now used simulations to address this question.Injecting MassBalick and collaborators use 3D hydrodynamic simulations to model one particular pre-planetary nebula, OH231, which lies 4,200 light-years away and is about 1.4 light-years long. This is a well studied nebula, so the team had many observations that their model needed to successfully replicate: the nebulas shapes, dimensions, overall geometry, locations of shocks, timescales, and even velocity gradients are known.The authors model included mass injection from the central source into the ambient gas in three different ways:clumps: spherical knots injected all at once,cylindrical jets: thin outflows with parallel streamlines, andsprays: conical outflows with diverging streamlines.Explanation from a Champagne BottlePanel A: best-fitting simulations of OH231 200, 400, and 800 yr after the clump and spray are launched. Panel B: example from the same family of solutions, in which the mass is reduced by a factor of 10. Click for a closer look. [Balick et al. 2017]Balick and collaborators found that by injecting the mass in these three ways with a specific order and spacing, they were able to find a family of solutions that very well replicated observations of OH231. In the best-fitting model, combinations of pairs of clumps are embedded within sprays of brief duration and launched into static ancient AGB winds. The authors compare the setup to the ejection of the cork and the spray of high-pressure fluid when a bottle of champagne is opened.These simulations successfully map out all but perhaps the first century of the nebulas evolution and give us some of the best insight yet into how these short-lived objects are formed. The authors are now working to reproduce these simulations for other pre-planetary nebulae, with the goal of piecing together common attributes of their ejection histories.CitationBruce Balick et al 2017 ApJ 843 108. doi:10.3847/1538-4357/aa77f0

Modelling grain alignment by radiative torques and hydrogen formation torques in reflection nebula

NASA Astrophysics Data System (ADS)

Hoang, Thiem; Lazarian, A.; Andersson, B.-G.

2015-04-01

Reflection nebulae - dense cores - illuminated by surrounding stars offer a unique opportunity to directly test our quantitative model of grain alignment based on radiative torques (RATs) and to explore new effects arising from additional torques. In this paper, we first perform detailed modelling of grain alignment by RATs for the IC 63 reflection nebula illuminated both by a nearby γ Cas star and the diffuse interstellar radiation field. We calculate linear polarization pλ of background stars by radiatively aligned grains and explore the variation of fractional polarization (pλ/AV) with visual extinction AV across the cloud. Our results show that the variation of pV/AV versus AV from the dayside of IC 63 to its centre can be represented by a power law (p_V/A_V∝ A_V^{η }) with different slopes depending on AV. We find a shallow slope η ˜ -0.1 for AV < 3 and a very steep slope η ˜ -2 for AV > 4. We then consider the effects of additional torques due to H2 formation and model grain alignment by joint action of RATs and H2 torques. We find that pV/AV tends to increase with an increasing magnitude of H2 torques. In particular, the theoretical predictions obtained for pV/AV and peak wavelength λmax in this case show an improved agreement with the observational data. Our results reinforce the predictive power of the RAT alignment mechanism in a broad range of environmental conditions and show the effect of pinwheel torques in environments with efficient H2 formation. Physical parameters involved in H2 formation may be constrained using detailed modelling of grain alignment combined with observational data. In addition, we discuss implications of our modelling for interpreting latest observational data by Planck and other ground-based instruments.

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease.

PubMed

Croese, John; Giacomin, Paul; Navarro, Severine; Clouston, Andrew; McCann, Leisa; Dougall, Annette; Ferreira, Ivana; Susianto, Atik; O'Rourke, Peter; Howlett, Mariko; McCarthy, James; Engwerda, Christian; Jones, Dianne; Loukas, Alex

2015-02-01

Celiac disease (CeD) is a common gluten-sensitive autoimmune enteropathy. A gluten-free diet is an effective treatment, but compliance is demanding; hence, new treatment strategies for CeD are required. Parasitic helminths hold promise for treating inflammatory disorders, so we examined the influence of experimental hookworm infection on the predicted outcomes of escalating gluten challenges in CeD subjects. A 52-week study was conducted involving 12 adults with diet-managed CeD. Subjects were inoculated with 20 Necator americanus larvae, and escalating gluten challenges consumed as pasta were subsequently administered: (1) 10 to 50 mg for 12 weeks (microchallenge); (2) 25 mg daily + 1 g twice weekly for 12 weeks (GC-1g); and (3) 3 g daily (60-75 straws of spaghetti) for 2 weeks (GC-3g). Symptomatic, serologic, and histological outcomes evaluated gluten toxicity. Regulatory and inflammatory T cell populations in blood and mucosa were examined. Two gluten-intolerant subjects were withdrawn after microchallenge. Ten completed GC-1g, 8 of whom enrolled in and completed GC-3g. median villous height-to-crypt depth ratios (2.60-2.63; P = .98) did not decrease as predicted after GC-1g, and the mean IgA-tissue transglutaminase titers declined, contrary to the predicted rise after GC-3g. quality of life scores improved (46.3-40.6; P = .05); celiac symptom indices (24.3-24.3; P = .53), intra-epithelial lymphocyte percentages (32.5-35.0; P = .47), and Marsh scores were unchanged by gluten challenge. Intestinal T cells expressing IFNγ were reduced following hookworm infection (23.9%-11.5%; P = .04), with corresponding increases in CD4(+) Foxp3(+) regulatory T cells (0.19%-1.12%; P = .001). Necator americanus and gluten microchallenge promoted tolerance and stabilized or improved all tested indices of gluten toxicity in CeD subjects. Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Intrinsic and scattering attenuation of high-frequency S-waves in the central part of the External Dinarides

NASA Astrophysics Data System (ADS)

Majstorović, Josipa; Belinić, Tena; Namjesnik, Dalija; Dasović, Iva; Herak, Davorka; Herak, Marijan

2017-09-01

The central part of the External Dinarides (CED) is a geologically and tectonically complex region formed in the collision between the Adriatic microplate and the European plate. In this study, the contributions of intrinsic and scattering attenuation ( Q i - 1 and Q sc - 1 , respectively) to the total S-wave attenuation were calculated for the first time. The multiple lapse-time window analysis (MLTWA method), based on the assumptions of multiple isotropic scattering in a homogeneous medium with uniformly distributed scatterers, was applied to seismograms of 450 earthquakes recorded at six seismic stations. Selected events have hypocentral distances between 40 and 90 km with local magnitudes between 1.5 and 4.7. The analysis was performed over 11 frequency bands with central frequencies between 1.5 and 16 Hz. Results show that the seismic albedo of the studied area is less than 0.5 and Q i - 1 > Q sc - 1 at all central frequencies and for all stations. These imply that the intrinsic attenuation dominates over scattering attenuation in the whole study area. Calculated total S-wave and expected coda wave attenuation for CED are in a very good agreement with the ones measured in previous studies using the coda normalization and the coda-Q methods. All estimated attenuation factors decrease with increasing frequency. The intrinsic attenuation for CED is among the highest observed elsewhere, which could be due to the highly fractured and fluid-filled carbonates in the upper crust. The scattering and the total S-wave attenuation for CED are close to the average values obtained in other studies performed worldwide. In particular, good agreement of frequency dependence of total attenuation in CED and in the regions that contributed most strong-motion records for ground motion prediction equations used in PSHA in Croatia indicates that those were well chosen and applicable to this area as far as their attenuation properties are concerned.

Prolonged Attenuation of Amygdala-Kindled Seizure Measures in Rats by Convection-Enhanced Delivery of the N-Type Calcium Channel Antagonists ω-Conotoxin GVIA and ω-Conotoxin MVIIA

PubMed Central

Gasior, Maciej; White, Natalie A.; Rogawski, Michael A.

2008-01-01

Convection-enhanced delivery (CED) permits the homogeneous distribution of therapeutic agents throughout localized regions of the brain parenchyma without causing tissue damage as occurs with bolus injection. Here, we examined whether CED infusion of the N-type calcium channel antagonists ω-conotoxin GVIA (ω-CTX-G) and ω-conotoxin MVIIA (ω-CTX-M) can attenuate kindling measures in fully amygdala-kindled rats. Rats were implanted with a combination infusion cannula-stimulating electrode assembly into the right basolateral amygdala. Fully kindled animals received infusions of vehicle, ω-CTX-G (0.005, 0.05, and 0.5 nmol), ω-CTX-M (0.05, 0.15, and 0.5 nmol), proteolytically inactivated ω-CTX-M (0.5 nmol), or carbamazepine (500 nmol) into the stimulation site. CED of ω-CTX-G and ω-CTX-M over a 20-min period resulted in a dose-dependent increase in the afterdischarge threshold and a decrease in the afterdischarge duration and behavioral seizure score and duration during a period of 20 min to 1 week after the infusion, indicating an inhibitory effect on the triggering and expression of kindled seizures. The protective effects of ω-conotoxins reached a maximum at 48 h postinfusion, and then they gradually resolved over the next 5 days. In contrast, carbamazepine was active at 20 min but not at 24 h after the infusion, whereas CED of vehicle or inactivated ω-CTX-M had no effect. Except for transient tremor in some rats receiving the highest toxin doses, no adverse effects were observed. These results indicate that local CED of high-molecular-weight presynaptic N-type calcium channel blockers can produce long-lasting inhibition of brain excitability and that they may provide prolonged seizure protection in focal seizure disorders. PMID:17717191

Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma.

PubMed

Sonabend, Adam M; Carminucci, Arthur S; Amendolara, Benjamin; Bansal, Mukesh; Leung, Richard; Lei, Liang; Realubit, Ronald; Li, Hai; Karan, Charles; Yun, Jonathan; Showers, Christopher; Rothcock, Robert; O, Jane; Califano, Andrea; Canoll, Peter; Bruce, Jeffrey N

2014-09-01

Glioblastoma subtypes have been defined based on transcriptional profiling, yet personalized care based on molecular classification remains unexploited. Topoisomerase II (TOP2) contributes to the transcriptional signature of the proneural glioma subtype. Thus, we targeted TOP2 pharmacologically with etoposide in proneural glioma models. TOP2 gene expression was evaluated in mouse platelet derived growth factor (PDGF)(+)phosphatase and tensin homolog (PTEN)(-/-)p53(-/-) and PDGF(+)PTEN(-/-) proneural gliomas and cell lines, as well as human glioblastoma from The Cancer Genome Atlas. Correlation between TOP2 transcript levels and etoposide susceptibility was investigated in 139 human cancer cell lines from the Cancer Cell Line Encyclopedia public dataset and in mouse proneural glioma cell lines. Convection-enhanced delivery (CED) of etoposide was tested on cell-based PDGF(+)PTEN(-/-)p53(-/-) and retroviral-based PDGF(+)PTEN(-/-) mouse proneural glioma models. TOP2 expression was significantly higher in human proneural glioblastoma and in mouse proneural tumors at early as well as late stages of development compared with normal brain. TOP2B transcript correlated with susceptibility to etoposide in mouse proneural cell lines and in 139 human cancer cell lines from the Cancer Cell Line Encyclopedia. Intracranial etoposide CED treatment (680 μM) was well tolerated by mice and led to a significant survival benefit in the PDGF(+)PTEN(-/-)p53(-/-) glioma model. Moreover, etoposide CED treatment at 80 μM but not 4 μM led to a significant survival advantage in the PDGF(+)PTEN(-/-) glioma model. TOP2 is highly expressed in proneural gliomas, rendering its pharmacological targeting by intratumoral administration of etoposide by CED effective on murine proneural gliomas. We provide evidence supporting clinical testing of CED of etoposide with a molecular-based patient selection approach. Published by Oxford University Press on behalf of the Society for Neuro-Oncology 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept.

PubMed

Halle, Bo; Marcusson, Eric G; Aaberg-Jessen, Charlotte; Jensen, Stine S; Meyer, Morten; Schulz, Mette K; Andersen, Claus; Kristensen, Bjarne W

2016-01-01

Over-expressed microRNAs (miRs) are promising new targets in glioblastoma (GBM) therapy. Inhibition of over-expressed miRs has been shown to diminish GBM proliferation, invasion and angiogenesis, indicating a significant therapeutic potential. However, the methods utilized for miR inhibition have had low translational potential. In clinical trials convection-enhanced delivery (CED) has been applied for local delivery of compounds in the brain. The aim of this study was to determine if safe and efficient miR inhibition was possible by CED of an anti-miR. We used a highly invasive GBM orthotopic xenograft model and targeted a well-validated miR, let-7a, with a 2'-O-methoxyethyl anti-miR with a combined phosphodiester/phosphorothioate backbone to establish an initial proof of concept. In vitro, anti-let-7a was delivered unassisted to the patient-derived T87 glioblastoma spheroid culture. In vivo, anti-let-7a or saline were administered by CED into orthotopic T87-derived tumors. After 1 month of infusion, tumors were removed and tumor mRNA levels of the target-gene High-mobility group AT-hook 2 (HMGA2) were determined. In vitro, 5 days inhibition was superior to 1 day at de-repressing the let-7a target HMGA2 and the inhibition was stable for 24 h. In vivo, anti-miR integrity was preserved in the pumps and no animals showed signs of severe adverse effects attributable to the anti-miR treatment. HMGA2 tumor level was significantly de-repressed in the anti-miR treated animals. The results showed-as an initial proof of concept-that miRs can be efficiently inhibited using CED delivery of anti-miR. The next step is to apply CED for anti-miR delivery focusing on key oncogenic miRs.

Optical spectroscopy of known and suspected Herbig-Haro objects

NASA Technical Reports Server (NTRS)

Cohen, M.; Fuller, G. A.

1985-01-01

Optical spectra of a number of suspected Herbig-Haro objects are presented. From these, the nature of these nebulosities are determined. Several of the nebulae are of very high density, perhaps due to their extreme youth. Extinctions measured toward DG Tau HH and the L1551 IRS 5 optical jet are in each case substantially less than the stellar values. It is suggested that this phenomenon reflects the existence of appreciably thick circumstellar dust disks around these, and two additional, exciting stars. Shock model diagnostics suggest that the emission lines in these Herbig-Haro nebulae arise in modest velocity shocks with sizable preshock densities in several cases. Radial velocities enable lower limits to be placed on the mass loss rates of those stars that have been detected in the radio continuum.

Turbulent Size Selection and Concentration of Chondrule-Sized Objects: Reynolds Number Invariance and Implications

NASA Technical Reports Server (NTRS)

Cuzzi, J. N.; Hogan, R.; Dobrovolskis, A.; Paque, J.

2006-01-01

It is generally agreed that individual chondrules formed as entities in a gaseous nebula prior to being accumulated into a meteorite parent body, within which they incur various forms of modification before arriving in our labs. While there are major unanswered questions about the properties of the nebula environment in which chondrules formed, the process by which the most primitive meteorites are formed overwhelmingly from chondrules must then be an aspect of "nebula processing". Textures in certain fragments of primitive meteorites might be summarized as being primarily chondrules and clastic, chondrule-sized, fragments of other minerals, each covered with a rim of fine dust with physical and chemical properties which are essentially independent of the composition and mineralogy of the underlying chondrule. This (unfortunately rather rare) texture was called "primary accretionary texture" to reflect their belief that it precedes subsequent stages in which fragmentation, comminution, mixing, heating, and other forms of alteration occur on the parent body(-ies). The size distribution of these chondrules and fragments, and the properties of their dusty rims, are key clues regarding the primary nebula accretion process. Even in the much more abundant meteorites which have clearly suffered internal mixing, abrasion, grinding, and even mineralogical alteration or replacement (due presumably to the collisional growth and heating process itself), key chondrule properties such as mean size and density remain relatively well defined, and well defined rims persist in many cases. It has been our goal to infer the key nebula processes indirectly from the properties of these very earliest primitive meteorites by making use of a theoretical framework in which the nebula possesses a plausible level of isotropic turbulence. We have shown that turbulence has the property of concentrating one particular particle size by orders of magnitude, where the preferentially concentrated size depends primarily on the intensity of the turbulent kinetic energy (represented by the Reynolds number of the nebula). Specifically, the preferentially concentrated particle is that which has a stopping time equal to the turnover time of the smallest eddy. The intensity level of turbulence implied by chondrule sizes can be maintained by even a small fraction of the energy released by the radially evolving disk (it must be noted that the details of how this transfer of energy actually occurs remain obscure, however).

On geometric distance determination to the Cepheid RS Puppis from its light echoes

NASA Astrophysics Data System (ADS)

Bond, H. E.; Sparks, W. B.

2009-02-01

Context: The luminous Galactic Cepheid RS Puppis is unique in being surrounded by a dust nebula illuminated by the variable light of the Cepheid. In a recent paper in this journal, Kervella et al. (2008) report a very precise geometric distance to RS Pup, based on measured phase lags of the light variations of individual knots in the reflection nebula. Aims: In this commentary, we examine the validity of the distance measurement, as well as the reality of the spatial structure of the nebula determined by Feast (2008) based upon the phase lags of the knots. Methods: Kervella et al. assumed that the illuminated dust knots lie, on average, in the plane of the sky (otherwise it is not possible to derive a geometric distance from direct imaging of light echoes). We consider the biasing introduced by the high efficiency of forward scattering. Results: We conclude that most of the knots are in fact likely to lie in front of the plane of the sky, thus invalidating the Kervella et al. result. We also show that the flat equatorial disk structure determined by Feast is unlikely; instead, the morphology of the nebula is more probably bipolar, with a significant tilt of its axis with respect to the plane of the sky. Conclusions: Although the Kervella et al. distance result is invalidated, we show that high-resolution polarimetric imaging has the potential to yield a valid geometric distance to this important Cepheid.

Really Hot Stars

NASA Astrophysics Data System (ADS)

2003-04-01

Spectacular VLT Photos Unveil Mysterious Nebulae Summary Quite a few of the most beautiful objects in the Universe are still shrouded in mystery. Even though most of the nebulae of gas and dust in our vicinity are now rather well understood, there are some which continue to puzzle astronomers. This is the case of a small number of unusual nebulae that appear to be the subject of strong heating - in astronomical terminology, they present an amazingly "high degree of excitation". This is because they contain significant amounts of ions, i.e., atoms that have lost one or more of their electrons. Depending on the atoms involved and the number of electrons lost, this process bears witness to the strength of the radiation or to the impact of energetic particles. But what are the sources of that excitation? Could it be energetic stars or perhaps some kind of exotic objects inside these nebulae? How do these peculiar objects fit into the current picture of universal evolution? New observations of a number of such unusual nebulae have recently been obtained with the Very Large Telescope (VLT) at the ESO Paranal Observatory (Chile). In a dedicated search for the origin of their individual characteristics, a team of astronomers - mostly from the Institute of Astrophysics & Geophysics in Liège (Belgium) [1] - have secured the first detailed, highly revealing images of four highly ionized nebulae in the Magellanic Clouds, two small satellite galaxies of our home galaxy, the Milky Way, only a few hundred thousand light-years away. In three nebulae, they succeeded in identifying the sources of energetic radiation and to eludicate their exceptional properties: some of the hottest, most massive stars ever seen, some of which are double. With masses of more than 20 times that of the Sun and surface temperatures above 90 000 degrees, these stars are truly extreme. PR Photo 09a/03: Nebula around the hot star AB7 in the SMC. PR Photo 09b/03: Nebula near the hot Wolf-Rayet star BAT99-2 in the LMC. PR Photo 09c/03: Nebula near the hot binary star BAT99-49 in the LMC. PR Photo 09d/03: The N44C Nebula in the LMC. Four unique images of highly excited nebulae in the Magellanic Clouds ESO PR Photo 09a/03 ESO PR Photo 09a/03 [Preview - JPEG: 400 x 472 pix - 74k [Normal - JPEG: 800 x 943 pix - 720k] [Full-Res - JPEG: 1200 x 1414 pix - 1.2M] ESO PR Photo 09b/03 ESO PR Photo 09b/03 [Preview - JPEG: 400 x 466 pix - 70k [Normal - JPEG: 800 x 931 pix - 928k] [Full-Res - JPEG: 1200 x 1397 pix - 1.8M] ESO PR Photo 09c/03 ESO PR Photo 09c/03 [Preview - JPEG: 400 x 469 pix - 74k [Normal - JPEG: 800 x 937 pix - 1.1M] [Full-Res - JPEG: 1200 x 1405 pix - 2.2M] ESO PR Photo 09d/03 ESO PR Photo 09d/03 [Preview - JPEG: 400 x 473 pix - 28k [Normal - JPEG: 800 x 945 pix - 368k] [Full-Res - JPEG: 1200 x 1418 pix - 600k] Captions: PR Photo 09a/03 is a reproduction of a "near-true" three-colour composite image of the highly excited nebula around the hot double star AB7 in the Small Magellanic Cloud (SMC), obtained in January 2002 with the FORS1 multi-mode instrument at the 8.2-m VLT MELIPAL telescope at the Paranal Observatory (Chile). It is based on three exposures through narrow-band optical (interference) filters that isolate the light from specific atoms and ions. In this rendering, the blue colour represents the light from singly ionized Helium (He II; wavelength 468.6 nm; exposure time 30 min), green corresponds to doubly ionized oxygen ([O III]; 495.7 + 500.7 nm; 5 min) and red to hydrogen atoms (H; H-alpha line at 656.2 nm; 5 min). Of these three ions, He II is the tracer of high excitation, i.e. the bluest areas of the nebula are the hottest. The sky field measures 400 x 400 arcsec2; the original pixel size on the 2k x 2k CCD is 0.23 arcsec. North is up and east to the left. Before combination, the CCD frames were flat-fielded and cleaned of cosmic-rays. Moreover, the stars in the blue (He II) image were removed in order to provide a clearer view of the surrounding nebular emission. The reproduced brightness is proportional to the square-root of the actual intensity; this increases the "dynamical range" of the image, i.e. it shows better areas of very different brightness. PR Photo 09b/03 is a similar reproduction of the sky area with the nebula near the Wolf-Rayet (WR) star BAT99-2 in the LMC. The filters are the same, but the exposure times were 60, 5 and 5 min for the blue, green and red exposures, respectively. PR Photo 09c/03 shows, in the same way, the nebula around the hot double star BAT99-49 in the LMC. The filters are the same, but the exposure times were 45, 5 and 5 min for the blue, green and red exposures, respectively. Finally, PR Photo 09d/03 shows the N44C nebula in the LMC, photographed through the same optical filters with exposure times of 20, 5 and 5 min for the blue, green and red exposures, respectively. The sky field measures 208 x 208 arcsec2. The above collection of impressive VLT colour photos is unique. They show some of the highest excitation nebulae in the Magellanic Clouds (MCs), two satellite galaxies of our own Milky Way. They may be enjoyed for their beauty alone. However, each of them also carries a message about the depicted objects, their properties and evolutionary state. In fact, they represent the spectacular and visible result of a dedicated research programme begun by an international team of astronomers from Belgium and the United States of America [1], and aimed at unravelling the secrets of unsually hot nebulae. What makes them shine? From where come the enormous energies needed to make these nebulae glow in the light of ionized helium atoms? Emission nebulae Nebulae are huge clouds of gas and dust, the cosmic material from which stars and planets form, cf. the Appendix. Many of them emit their own light, and are then called emission nebulae. Astronomers distinguish between Planetary Nebulae (PNe), Supernova Remnants (SNRs) and "normal" emission nebulae or "HII regions" (pronounced "Eitch-two"). PNe result from the death of comparatively light stars, similar to our Sun, while SNRs originate from the explosive death of heavier stars. The collision between the surrounding interstellar matter and that ejected by the dying star, accompanied by the intense radiation from the hot stellar remnant (white dwarf, neutron star) excites the gas and makes it shine brightly. But the radiation of young hot stars embedded in an interstellar cloud is also able to heat the surrounding gas, resulting in the apparition of another type of emission nebula, that shines mostly in the light of ionized hydrogen (H) atoms. Such nebulae are therefore often referred to as "HII regions". The well-known Orion Nebula is an outstanding example of that type of nebula, cf. ESO PR Photos 03a-c/01. Highly excited nebulae The hotter the central object of an emission nebula, whether a white dwarf, a neutron star or just a young star, the hotter and more excited will be the surrounding nebula. The word "excitation" refers to the degree of ionization of the nebular gas. The more energetic the impinging particles and radiation, the more electrons will be lost and higher is the degree of excitation. Only in the most excited nebulae is there enough ultraviolet energy to completely ionize the helium atoms. When these ions subsequently capture an electron, this process gives rise to the characteristic radiation of single ionized helium (HeII). A particularly useful way to trace the very highest excitation areas is thus to map the distribution of HeII by means of imaging or spectroscopic observations that are sensitive to the radiation from these helium ions, for example at a particular wavelength in blue light (468.6 nm). It is common to detect the presence of HeII in Planetary Nebulae around extremely hot white dwarf stars, but not in "normal" HII regions. However, a few otherwise seemingly normal HII regions reveal the characteristics of high excitation. One of them is located in our own Milky Way galaxy, another has been found in the nearby galaxy IC 1613, and five others are situated in the Magellanic Clouds. Astronomers have also detected the presence of HeII ions in a number of remote galaxies undergoing a phase of intense star formation ("starburst galaxies") and in the vicinity of ultraluminous X-ray sources in very distant galaxies. What is going on in those remote objects in the early Universe? Do we see the action of young and very hot stars or is something unknown going on? What can the existence of those hot nebulae in young galaxies tell about the evolution of our own Milky Way? Searching for the energy source We would like to know, but those distant nebulae are unfortunately too faint to be studied in any reasonable detail, even by means of the largest available telescopes. The only way forward is therefore to look closer at the nearest ones in the hope that they will provide clues about the processes leading to the observed high excitation and thus help to better understand their cousins in those distant galaxies. There appears to be three possible answers to the basic question about the nature of the energetic sources that heat these strange emission nebulae: * very fast particles: if there is in the area a fast-moving gas (more than 100 km/s), the shock created by the impact of this material is able to heat the ambient interstellar medium sufficiently to produce a HeII nebula. * ultraviolet emission from massive stars: according to the most recent model calculations, even the most massive O-type stars do not emit enough ultraviolet light to ionize a sufficient number of helium atoms in the surrounding nebula to produce a detectable HeII nebula. However, some of the hottest stars of the so-called Wolf-Rayet (W-R) type (that are the evolved descendants of O-stars) may produce enough high energy emission to completely ionize the helium atoms in their surroundings. * intense X-ray emission: close binary stars in which one component is a "compact" object (a white dwarf, a neutron star, or a black hole) and the other an "ordinary" star can produce an intense X-ray emission. This happens because the compact object is so dense and massive that it siphons off matter from its companion star - astronomers refer to this as an accretion process, sometimes also called "stellar cannibalism". When the "stolen" matter approaches the compact object, it gradually heats up and may reach temperatures of millions of degrees. It then emits X-rays. At the same time, ultraviolet radiation is also emitted, which may produce high excitation regions in the surrounding nebula. This scenario can also explain the association of HeII nebulae with ultraluminous X-ray sources in other galaxies. VLT observations of highly excited nebulae in the MCs Observations of a number of highly excited nebulae in the Magellanic Clouds were carried out by a team composed of Belgian and American astronomers [1] in January 2002, by means of the FORS1 multi-mode instrument at the 8.2-m VLT MELIPAL telescope. Detailed images were obtained through various special optical filters - they bring into light the complex structure of these nebulae and reveal for the first time the exact morphology of the high excitation zones. Some of exposures have been combined to produce the colour photos shown in PR Photos 09a-d/03. Here, the blue colour traces the exceptional HeII emission, whilst the red and green correspond to the more common nebular emissions from atomic hydrogen and doubly-ionized oxygen, respectively. All four nebulae shown were found to be associated with very hot stars. They carry rather prosaic names: BAT99-2 and BAT99-49, AB7 and N44C Star #2 [2]. The first three of these objects contain some of the highly evolved massive stars, of the so-called Wolf-Rayet (WR) type, while the fourth is an mid-age massive star, of type O. Massive stars, with masses more than 20 times that of the Sun, are very bright (100,000 to 10 million times brighter than the Sun), very blue and very hot, with surface temperatures of a few tens of thousands of degrees. Another property of these exceptional stars is their very strong stellar winds: they continuously eject energetic particles - like the "solar wind" from the Sun - but some 10 to 1000 million times more intensely than our star! These powerful winds exert an enormous pressure on the surrounding interstellar material and forcefully shape those clouds into "bubbles". These photos have now provided the astronomers with sufficient information to understand exactly what is going on in three of those unusual nebulae - while one case still remains ambiguous. The nebulae around BAT99-2, BAT99-49 and AB7 BAT99-2 (cf. PR Photo 09b/03) is one of the hottest WR-stars known in the Large Magellanic Cloud (LMC). Before this star reached this phase of its short life, the strong stellar wind from its progenitor O-type star swept the interstellar medium and created a "bubble", much like a snowplough pushes aside the snow on a road. Part of this "bubble" can still be seen as a large half-ring to the south of the star. When the star did become a WR, the increasingly intense stellar wind impacted on the material previously ejected from the star. This created a new bubble, now visible as a small arc-like structure to the north-west of the star. We are appparently witnessing an ongoing merger of these two bubbles. With its strong ultraviolet (UV) radiation, BAT99-2 is strongly heating its immediate surroundings, in particular the above mentioned arc-like feature that, due to the resulting high excitation, is seen as a violet-pink region in the colour image. The entire field is very complex - the presence of a supernova remnant (SNR) is revealed by a few faint red filaments rather close to the high excitation nebula, to the north-west of the arc-like structure. AB7 (PR Photo 09a/03) and BAT99-49 (PR Photo 09c/03) are both binary stars, consisting of one WR-star and a companion O-type star. Like in the case of BAT99-2, the strong UV-radiation from their WR-star has created HeII nebulae around them, well visible in the photos by their blue colour. AB7 is particularly remarkable: the associated huge nebula and HeII region indicate that this star is one of the, if not THE, hottest WR-star known so far, with a surface temperature in excess of 120,000 degrees! Just outside this nebula, a small network of green filaments is visible - they are the remains of another supernova explosion. The new VLT images, complemented with VLT spectra, demonstrate that these stars are indeed the source of the observed ionization. These very first maps of the HeII emission unveil the as yet undiscovered complex structure of those highly excited nebulae. Moreover, the new observations provide the first accurate determination of the true ionizing power of these exceptional stars. They allow a direct measurement of the otherwise unobservable intensity of the far-UV emission of WR stars. The new observations have clearly identified the ultraviolet emission of very massive stars as the energy source in these three nebulae. Using the latest theoretical models to interpret these unique data, the Belgian astronomers and their American collaborator were also able to show that all of these stars are hotter than 90,000 degrees! The N44C nebula The fourth photo, PR Photo 09d/03, shows the very peculiar nebula N44C in the LMC. There is a beautiful (blue) HeII nebula near the two central stars. It is very different from the larger, "normal" HII region that is delimited by the light from atomic hydrogen (red) and doubly-ionized oxygen (green): this hot central region of N44C rather appears to "enshroud" the stars like a veil. There is a mystery, though. With a temperature of "only" a few tens of thousand degrees, even the hottest of the two stars, an O-type star (the upper one), cannot possibly be responsible for this inner high excitation nebula [3]. Moreover, no fast motions have so far been detected in the vicinity. Some astronomers have suggested that N44C is a "fossil X-ray nebula". What does that mean ? It may well be that this O-type star is not alone, but actually possesses a compact companion. The X-ray emission from such a binary may not be constant. During their orbital motion, the two stars can move away from each other, and the larger separation may cause the X-ray emission to stop (because of the cessation of accretion of matter onto the compact object). In this case, the observed high excitation nebula could still persist for a short period of time as a "fossil" of the previous X-ray ionized nebula. Later, that part of the nebula would then gradually disappear. However, to the astonishment of the astronomers, the present VLT observations show little or no variation in the HeII emission. Thus the above described "fossil X-ray nebula" explanation does not appear to be completely adequate and the cause of the high excitation in N44C remains a challenge to astronomers. "You can't win them all", says Yaël Nazé. "We were able to fully understand three nebulae, but we must now look more closely at N44C. I would not be surprised, if we will be able to solve this riddle by means of additional VLT observations." More information The information contained in this press release is based on two research articles to be published in the European research journal "Astronomy & Astrophysics", one of which is available at the preprint website at the Institut d'Astrophysique et de Géophysique de Liège (Belgium). Notes [1]: The team consists of Yaël Nazé, Grégor Rauw, Jean Manfroid and Jean-Marie Vreux (Liège Institute, Belgium), and You-Hua Chu (University of Illinois, USA). [2]: The names of these stars refer to the research papers in which they were first decribed. BAT99-2 and BAT99-49 are nos. 2 and 49 in the list published by Breysacher, Azzopardi and Testor (A&AS, 137, 117, 1999), AB7 is star no. 7 in the list by Azzopardi and Breysacher (A&A, 75, 120, 1979) and N44C Star #2 is included in a paper by Stasinska, Testor and Heydari-Malayeri (A&A, 170, L4, 1986). [3]: Consequently, contrary to what was possible in the other three nebulae, the observed extent of that nebula does not allow measuring the temperature of the hot O-type star. Contact Yaël Nazé Institut d'Astrophysique et de Géophysique Liège, Belgium Phone: +32 4 366 97 20 email: naze@astro.ulg.ac.be Appendix: Different types of nebulae   Nebulae are huge clouds of gas and dust, the cosmic material from which stars and planets form. Most of them belong to five main categories, each representing a different physical state. Two of these do not shine by their own light, but three others do. Dark nebulae and reflection nebulae If the gas does not emit visible light by itself, astronomers talk about dark nebulae or reflection nebulae. The former block the light from objects behind them, and they are therefore seen as dark regions in the sky - famous examples are the Barnard 68 "globule" (cf. ESO ESO PR 01/01 and ESO PR Photos 29a-c/99) and the "Horsehead Nebula" (ESO PR Photos 02a-b/02). Contrarily, reflection nebulae appear as bright areas in the sky because their dust particles reflect the light emitted by nearby stars. A good example is the nebulae surrounding some of the brightest stars in the "Pleiades" stellar cluster or in the southern Chamaeleon I area, cf. ESO PR Photo 17c/99. Emission nebulae Other nebulae emit visible light of their own. Astronomers distinguish between Planetary Nebulae (PNs), Supernova Remnants (SNRs) and "normal" emission nebulae or "HII regions" (pronounced "Eitch-two"). When stars die, they eject copious amounts of matter into neighbouring space. These ejecta collide with and heat the surrounding interstellar matter. This is sometimes accompanied by intense radiation from the hot stellar remnant at the centre. These processes excite the interstellar gas (and the ejecta) so that they shine brightly. In the case of lighter stars like the Sun, the remnant object is a hot "white dwarf", a star barely larger than the Earth and the surrounding nebula is called a "Planetary Nebula (PN)". This historical term refers to the planet-like appearance of such a nebula in a small telescope. A fine example is the "Dumbbell Nebula", photographed by the VLT in 1998, cf. ESO PR Photos 38a-b/98. On the other hand, heavier stars explode violently - such dramatic events are seen as supernovae - and leave behind a exceedingly hot and dense, rotating "neutron star" of diameter 10-20 km (or, in the case of the heaviest stars, presumably a "black hole") as well as a surrounding nebula, the supernova remnant (SNR). A famous example is the "Crab Nebula" from the supernova that exploded in the year 1054, cf. ESO PR Photos 40f-i/99. Finally, the radiation of young hot stars embedded in an interstellar cloud is also able to heat the surrounding gas, resulting in the apparition of an emission nebula, that shines mostly in the light of ionized hydrogen (H) atoms. Such nebulae are therefore often referred to as "HII regions". The well-known Orion Nebula is an outstanding example of that type of nebula, cf. ESO PR Photos 03a-c/01.

Combined prevalence of inherited skeletal disorders in dog breeds in Belgium.

PubMed

Coopman, F; Broeckx, B; Verelst, E; Deforce, D; Saunders, J; Duchateau, L; Verhoeven, G

2014-01-01

Canine hip dysplasia (CHD), canine elbow dysplasia (CED), and humeral head osteochondrosis (HHOC) are inherited traits with uneven incidence in dog breeds. Knowledge of the combined prevalence of these three disorders is necessary to estimate the effect of the currently applied breeding strategies, in order to improve the genetic health of the population. Official screening results of the Belgian National Committee for Inherited Skeletal Disorders (NCSID) revealed that an average of 31.8% (CHD, CED, or both; n = 1273 dogs) and 47.2% (CHD, CED, HHOC, or a combination of these three diseases; n = 250 dogs) of dogs are mildly to severely affected by at least one skeletal disorder. According to the current breeding recommendations in some dog breeds in Belgium, these animals should be restricted (mild signs) or excluded (moderate to severe signs) from breeding. The introduction of genetic parameters, such as estimated breeding values, might create a better approach to gradually reduce the incidence of these complex inherited joint disorders, without compromising genetic population health.

IER-297 CED-2: Final Design for Thermal/Epithermal eXperiments with Jemima Plates with Polyethylene and Hafnium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, A. J.; Percher, C. M.; Zywiec, W. J.

This report presents the final design (CED-2) for IER-297, and focuses on 15 critical configurations using highly enriched uranium (HEU) Jemima plates moderated by polyethylene with and without hafnium diluent. The goal of the U.S. Nuclear Criticality Safety Program’s Thermal/Epithermal eXperiments (TEX) is to design and conduct new critical experiments to address high priority nuclear data needs from the nuclear criticality safety and nuclear data communities, with special emphasis on intermediate energy (0.625 eV – 100 keV) assemblies that can be easily modified to include various high priority diluent materials. The TEX (IER 184) CED-1 Report [1], completed in 2012,more » demonstrated the feasibility of meeting the TEX goals with two existing NCSP fissile assets, plutonium Zero Power Physics Reactor (ZPPR) plates and highly enriched uranium (HEU) Jemima plates. The first set of TEX experiments will focus on using the plutonium ZPPR plates with polyethylene moderator and tantalum diluents.« less

Mapping Urban Risk: Flood Hazards, Race, & Environmental Justice In New York”

PubMed Central

Maantay, Juliana; Maroko, Andrew

2009-01-01

This paper demonstrates the importance of disaggregating population data aggregated by census tracts or other units, for more realistic population distribution/location. A newly-developed mapping method, the Cadastral-based Expert Dasymetric System (CEDS), calculates population in hyper-heterogeneous urban areas better than traditional mapping techniques. A case study estimating population potentially impacted by flood hazard in New York City compares the impacted population determined by CEDS with that derived by centroid-containment method and filtered areal weighting interpolation. Compared to CEDS, 37 percent and 72 percent fewer people are estimated to be at risk from floods city-wide, using conventional areal weighting of census data, and centroid-containment selection, respectively. Undercounting of impacted population could have serious implications for emergency management and disaster planning. Ethnic/racial populations are also spatially disaggregated to determine any environmental justice impacts with flood risk. Minorities are disproportionately undercounted using traditional methods. Underestimating more vulnerable sub-populations impairs preparedness and relief efforts. PMID:20047020

Efficient mixing of the solar nebula from uniform Mo isotopic composition of meteorites.

PubMed

Becker, Harry; Walker, Richard J

2003-09-11

The abundances of elements and their isotopes in our Galaxy show wide variations, reflecting different nucleosynthetic processes in stars and the effects of Galactic evolution. These variations contrast with the uniformity of stable isotope abundances for many elements in the Solar System, which implies that processes efficiently homogenized dust and gas from different stellar sources within the young solar nebula. However, isotopic heterogeneity has been recognized on the subcentimetre scale in primitive meteorites, indicating that these preserve a compositional memory of their stellar sources. Small differences in the abundance of stable molybdenum isotopes in bulk rocks of some primitive and differentiated meteorites, relative to terrestrial Mo, suggest large-scale Mo isotopic heterogeneity between some inner Solar System bodies, which implies physical conditions that did not permit efficient mixing of gas and dust. Here we report Mo isotopic data for bulk samples of primitive and differentiated meteorites that show no resolvable deviations from terrestrial Mo. This suggests efficient mixing of gas and dust in the solar nebula at least to 3 au from the Sun, possibly induced by magnetohydrodynamic instabilities. These mixing processes must have occurred before isotopic fractionation of gas-phase elements and volatility-controlled chemical fractionations were established.

Diffuse interstellar bands in reflection nebulae

NASA Technical Reports Server (NTRS)

Fischer, O.; Henning, Thomas; Pfau, Werner; Stognienko, R.

1994-01-01

A Monte Carlo code for radiation transport calculations is used to compare the profiles of the lambda lambda 5780 and 6613 Angstrom diffuse interstellar bands in the transmitted and the reflected light of a star embedded within an optically thin dust cloud. In addition, the behavior of polarization across the bands were calculated. The wavelength dependent complex indices of refraction across the bands were derived from the embedded cavity model. In view of the existence of different families of diffuse interstellar bands the question of other parameters of influence is addressed in short.

Design and Implementation of the CEBAF Element Database

DOE Office of Scientific and Technical Information (OSTI.GOV)

Theodore Larrieu, Christopher Slominski, Michele Joyce

2011-10-01

With inauguration of the CEBAF Element Database (CED) in Fall 2010, Jefferson Lab computer scientists have taken a first step toward the eventual goal of a model-driven accelerator. Once fully populated, the database will be the primary repository of information used for everything from generating lattice decks to booting front-end computers to building controls screens. A particular requirement influencing the CED design is that it must provide consistent access to not only present, but also future, and eventually past, configurations of the CEBAF accelerator. To accomplish this, an introspective database schema was designed that allows new elements, element types, andmore » element properties to be defined on-the-fly without changing table structure. When used in conjunction with the Oracle Workspace Manager, it allows users to seamlessly query data from any time in the database history with the exact same tools as they use for querying the present configuration. Users can also check-out workspaces and use them as staging areas for upcoming machine configurations. All Access to the CED is through a well-documented API that is translated automatically from original C++ into native libraries for script languages such as perl, php, and TCL making access to the CED easy and ubiquitous. Notice: Authored by Jefferson Science Associates, LLC under U.S. DOE Contract No. DE-AC05-06OR23177. The U.S. Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce this manuscript for U.S. Government purposes.« less

Induction of cap-independent BiP (hsp-3) and Bcl-2 (ced-9) translation in response to eIF4G (IFG-1) depletion in C. elegans

PubMed Central

Morrison, J Kaitlin; Friday, Andrew J; Henderson, Melissa A; Hao, Enhui; Keiper, Brett D

2014-01-01

During apoptosis, activated caspases cleave the translation initiation factor eIF4G. This cleavage disrupts cap-dependent mRNA translation initiation within the cell. However, a specific subset of mRNAs can still be recruited for protein synthesis in a cap-independent manner by the residual initiation machinery. Many of these mRNAs, including cell death related mRNAs, contain internal ribosome entry sites (IRESes) that promote their enhanced translation during apoptosis. Still other mRNAs have little dependence on the cap recognition mechanism. The expression of the encoded proteins, both anti- and pro-apoptotic, allows for an initial period of attempted cell survival, then commitment to cell death when damage is extensive. In this study we address the translational regulation of the stress and apoptosis-related mRNAs in C. elegans: BiP (hsp-3) (hsp-4), Hif-1 (hif-1), p53 (cep-1), Bcl-2 (ced-9) and Apaf-1 (ced-4). Altered translational efficiency of these messages was observed upon depletion of cap-dependent translation and induction of apoptosis within the C. elegans gonad. Our findings suggest a physiological link between the cap-independent mechanism and the enhanced translation of hsp-3 and ced-9. This increase in the efficiency of translation may be integral to the stress response during the induction of physiological apoptosis. PMID:26779406

The Curators of the University of Missouri Modeling the Infrared Emission of C_60 in Space

NASA Astrophysics Data System (ADS)

Li, Aigen

Fullerenes are cage-like molecules of pure carbon, such as C_60, C_70, C_76, and C_84. C_60, also known as buckminsterfullerene, is the most stable fullerene and has a soccer- ball like structure. The presence of fullerenes in space has been suggested and observationally explored since their first synthesis in the laboratory in 1985 by Harry Kroto and his colleagues which earned them the 1996 Nobel prize in chemistry. C_60 (as well as C_70) has recently been detected in reflection nebulae, post-AGB stars, protoplanetary nebulae, planetary nebulae, Herbig Ae/Be stars, and young stellar objects through their characteristic infrared emission bands. The formation of C_60 in interstellar and circumstellar environments is not firmly established. Experimental studies have shown that C_60 can be made by gas-phase condensation (e.g. through vaporization of graphite) in a hydrogen-poor environment. In view of the simultaneous detection of C_60 and PAHs in hydrogen-rich interstellar and circumstellar regions, it has also been suggested that C_60 could be generated by the decomposition of hydrogenated amorphous carbon, or the destruction of PAHs, both induced by shocks and/or UV photoprocessing. The phase (gas or solid) and excitation mechanism of C_60 in interstellar and circumstellar conditions are also hotly debated in the literature. One model suggests that C_60 is attached to dust and emits in solid-phase at the equilibrium temperature of the dust. Another model suggests that C_60 is stochastically excited by UV photons and emits in the gas-phase. We prefer the latter model as in interstellar and circumstellar conditions the energy content of a C_60 molecule is often smaller than the energy of a single starlight photon and C_60 is expected to undergo stochastical heating. We propose a two-year project to model the vibrational excitation of C_60 and calculate its infrared emission spectra in a wide variety of regions (e.g. reflection nebulae excited by stars of a range of effective temperatures, protoplanetary nebulae, planetary nebulae, the diffuse interstellar medium, and protoplanetary disks around Herbig Ae/Be stars), using the ``exact-statistical'' method developed by Draine & Li (2001) for modeling the photoexcitation of PAHs. We will calculate the intensity of each vibrational band of C_60 excited by a given-type radiation field of a given radiation strength. These results will be tabulated and made available to the community through the PI's website. We will use the calculated C_60 band intensities to analyze the observed C_60 spectra. This will allow us to derive the C_60 abundance and the emitting condition (e.g. starlight intensities) of the regions where C_60 is observed. Similarly, the same research will be applied to C_70 as well. This research supports the NASA Strategic Subgoal 3C: Discover the origin, structure, evolution, and destiny of the universe.

POLYCYCLIC AROMATIC HYDROCARBON EMISSION IN SPITZER/IRS MAPS. I. CATALOG AND SIMPLE DIAGNOSTICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stock, D. J.; Choi, W. D.-Y.; Moya, L. G. V.

2016-03-01

We present a sample of resolved galactic H ii regions and photodissociation regions (PDRs) observed with the Spitzer infrared spectrograph in spectral mapping mode between the wavelengths of 5–15 μm. For each object we have spectral maps at a spatial resolution of ∼4″ in which we have measured all of the mid-infrared emission and absorption features. These include the polycyclic aromatic hydrocarbon (PAH) emission bands, primarily at 6.2, 7.7, 8.6, 11.2, and 12.7 μm, as well as the spectral emission lines of neon and sulfur and the absorption band caused by silicate dust at around 9.8 μm. In this work wemore » describe the data in detail, including the data reduction and measurement strategies, and subsequently present the PAH emission band intensity correlations for each of the objects and the sample as a whole. We find that there are distinct differences between the sources in the sample, with two main groups: the first comprising the H ii regions and the second the reflection nebulae (RNe). Three sources—the reflection nebula NGC 7023, the Horsehead nebula PDR (an interface between the H ii region IC 434 and the Orion B molecular cloud), and M17—resist this categorization, with the Horsehead PDR points mimicking the RNe and the NGC 7023 fluxes displaying a unique bifurcated appearance in our correlation plots. These discrepancies seem to be due to the very low radiation field experienced by the Horsehead PDR and the very clean separation between the PDR environment and a diffuse environment in the NGC 7023 observations.« less

Study of the Polarization Properties of the Crab Nebula and Pulsar with BATSE

NASA Technical Reports Server (NTRS)

Forrest, David J.; Vestrand, W. T.; McConnell, Mark

1997-01-01

Activities carried out under this proposal included: 1) development and refinements of Monte Carlo simulations of the atmospheric reflected albedo hard x-ray emissions, both unpolarized and polarized, 2) modeling and simulations of the off-axis response of the BATSE LAD detectors, and 3) comparison of our simulation results with numerous BATSE flare and cosmic burst data sets.

International Ultraviolet Explorer (IUE)

NASA Technical Reports Server (NTRS)

Boehm, Karl-Heinz

1992-01-01

The observation, data reduction, and interpretation of ultraviolet spectra (obtained with the International Ultraviolet Explorer) of Herbig-Haro objects, stellar jets, and (in a few cases) reflection nebulae in star-forming regions is discussed. Intermediate results have been reported in the required semi-annual reports. The observations for this research were obtained in 23 (US1) IUE shifts. The spectra were taken in the low resolution mode with the large aperture. The following topics were investigated: (1) detection of UV spectra of high excitation Herbig-Haro (HH) objects, identification of emission lines, and a preliminary study of the energy distribution of the ultraviolet continuum; (2) details of the continuum energy distribution of these spectra and their possible interpretation; (3) the properties of the reddening (extinction) of HH objects; (4) the possible time variation of strong emission lines in high excitation HH objects; (5) the ultraviolet emission of low excitation HH objects, especially in the fluorescent lines of the H2 molecule; (6) the ultraviolet emission in the peculiar object HH24; (7) the spatial emission distribution of different lines and different parts of the continuum in different HH objects; and (8) some properties of reflection nebula, in the environment of Herbig-Haro objects. Each topic is discussed.

MCNeil's Nebula in Orion: The Outburst History

NASA Astrophysics Data System (ADS)

Briceño, C.; Vivas, A. K.; Hernández, J.; Calvet, N.; Hartmann, L.; Megeath, T.; Berlind, P.; Calkins, M.; Hoyer, S.

2004-05-01

We present a sequence of I-band images obtained at the Venezuela 1 m Schmidt telescope during the outburst of the nebula recently discovered by J. W. McNeil in the Orion L1630 molecular cloud. We derive photometry spanning the preoutburst state and the brightening itself, which is a unique record including 14 epochs and spanning a timescale of ~5 years. We constrain the beginning of the outburst at some time between 2003 October 28 and November 15. The light curve of the object at the vertex of the nebula, the likely exciting source of the outburst, reveals that it has brightened ~5 mag in about 4 months. The timescale for the nebula to develop is consistent with the light-travel time, indicating that we are observing light from the central source scattered by the ambient cloud into the line of sight. We also show recent FLWO optical spectroscopy of the exciting source and of the nearby HH 22. The spectrum of the source is highly reddened; in contrast, the spectrum of HH 22 shows a shock spectrum superposed on a continuum, most likely the result of reflected light from the exciting source reaching the HH object through a much less reddened path. The blue portion of this spectrum is consistent with an early B spectral type, similar to the early outburst spectrum of the FU Orionis variable star V1057 Cygni; we estimate a luminosity of L~219 Lsolar. The eruptive behavior of McNeil's Nebula, its spectroscopic characteristics and luminosity, suggest that we may be witnessing an FU Ori event on its way to maximum. By further monitoring this object, we will be able decide whether or not it qualifies as a member of this rare class of objects. Based on observations obtained at the Llano del Hato National Astronomical Observatory of Venezuela, operated by CIDA for the Ministerio de Ciencia y Tecnología, and at the Fred Lawrence Whipple Observatory (FLWO) of the Smithsonian Institution.

Trifid Triple Treat

NASA Astrophysics Data System (ADS)

2009-09-01

Today ESO has released a new image of the Trifid Nebula, showing just why it is a firm favourite of astronomers, amateur and professional alike. This massive star factory is so named for the dark dust bands that trisect its glowing heart, and is a rare combination of three nebula types, revealing the fury of freshly formed stars and presaging more star birth. Smouldering several thousand light-years away in the constellation of Sagittarius (the Archer), the Trifid Nebula presents a compelling portrait of the early stages of a star's life, from gestation to first light. The heat and "winds" of newly ignited, volatile stars stir the Trifid's gas and dust-filled cauldron; in time, the dark tendrils of matter strewn throughout the area will themselves collapse and form new stars. The French astronomer Charles Messier first observed the Trifid Nebula in June 1764, recording the hazy, glowing object as entry number 20 in his renowned catalogue. Observations made about 60 years later by John Herschel of the dust lanes that appear to divide the cosmic cloud into three lobes inspired the English astronomer to coin the name "Trifid". Made with the Wide-Field Imager camera attached to the MPG/ESO 2.2-metre telescope at ESO's La Silla Observatory in northern Chile, this new image prominently displays the different regions of the Trifid Nebula as seen in visible light. In the bluish patch to the upper left, called a reflection nebula, dusty gas scatters the light from nearby, Trifid-born stars. The largest of these stars shines most brightly in the hot, blue portion of the visible spectrum. This, along with the fact that dust grains and molecules scatter blue light more efficiently than red light - a property that explains why we have blue skies and red sunsets - imbues this portion of the Trifid Nebula with an azure hue. Below, in the round, pink-reddish area typical of an emission nebula, the gas at the Trifid's core is heated by hundreds of scorching young stars until it emits the red signature light of hydrogen, the major component of the gas, just as hot neon gas glows red-orange in illuminated signs all over the world. The gases and dust that crisscross the Trifid Nebula make up the third kind of nebula in this cosmic cloud, known as dark nebulae, courtesy of their light-obscuring effects. (The iconic Horsehead Nebula may be the most famous of these. Within these dark lanes, the remnants of previous star birth episodes continue to coalesce under gravity's inexorable attraction. The rising density, pressure and temperature inside these gaseous blobs will eventually trigger nuclear fusion, and yet more stars will form. In the lower part of this emission nebula, a finger of gas pokes out from the cloud, pointing directly at the central star powering the Trifid. This is an example of an evaporating gaseous globule, or "EGG", also seen in the Eagle Nebula, another star-forming region. At the tip of the finger, which was photographed by Hubble, a knot of dense gas has resisted the onslaught of radiation from the massive star. More information ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

Delineation of Ehlers-Danlos syndrome phenotype due to the c.934C>T, p.(Arg312Cys) mutation in COL1A1: Report on a three-generation family without cardiovascular events, and literature review.

PubMed

Colombi, Marina; Dordoni, Chiara; Venturini, Marina; Zanca, Arianna; Calzavara-Pinton, Piergiacomo; Ritelli, Marco

2017-02-01

Classical Ehlers-Danlos syndrome (cEDS) is a rare connective tissue disorder primarily characterized by hyperextensible skin, defective wound healing, abnormal scars, easy bruising, and generalized joint hypermobility; arterial dissections are rarely observed. Mutations in COL5A1 and COL5A2 encoding type V collagen account for more than 90% of the patients so far characterized. In addition, cEDS phenotype was reported in a small number of patients carrying the c.934C>T mutation in COL1A1 that results in an uncommon substitution of a non-glycine residue in one Gly-Xaa-Yaa repeat of the pro-α1(I)-chain p.(Arg312Cys), which leads to disturbed collagen fibrillogenesis due to delayed removal of the type I procollagen N-propeptide. This specific mutation has been associated with propensity to arterial rupture in early adulthood; indeed, in literature the individuals harboring this mutation are also referred to as "(classic) vascular-like" EDS patients. Herein, we describe a three-generation cEDS family with six adults carrying the p.(Arg312Cys) substitution, which show a variable and prevalent cutaneous involvement without any major vascular event. These data, together with those available in literature, suggest that vascular events are not a diagnostic handle to differentiate patients with the p.(Arg312Cys) COL1A1 mutation from those with COL5A1 and COL5A2 defects, and highlight that during the diagnostic process the presence of at least the p.(Arg312Cys) substitution in COL1A1 should be investigated in cEDS patients without type V collagen mutations. Nevertheless, for these patients, as well as for those affected with cEDS, a periodical vascular surveillance should be carried out together with cardiovascular risk factors monitoring. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

188Re-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas

PubMed Central

Allard, Emilie; Hindré, François; Passirani, Catherine; Lemaire, Laurent; Lepareur, Nicolas; Noiret, Nicolas; Menei, Philippe; Benoit, Jean-Pierre

2008-01-01

Purpose Lipid nanocapsules (LNC) entrapping lipophilic complexes of 188Re (188Re(S3CPh)2(S2CPh) [188Re-SSS]) were investigated as a novel radiopharmaceutical carrier for internal radiation therapy of malignant gliomas. The present study was designed to evaluate the efficacy of intracerebral administration of 188Re-SSS LNC by means of convection-enhanced delivery (CED) on a 9L rat brain tumour model. Methods Female Fischer rats with 9L glioma were treated with a single injection of 188Re-SSS LNC by CED 6 days after cell implantation. Rats were put into random groups according to the dose infused: 12, 10, 8, and 3 Gy in comparison with blank LNC, perrhenate solution (4Gy) and non-treated animals. The radionuclide brain retention level was evaluated by measuring 188Re elimination in faeces and urine over 72h after the CED injection. The therapeutic effect of 188Re-SSS LNC was assessed based on animal survival. Results CED of 188Re perrhenate solution resulted in rapid drug clearance with a brain T1/2 of 7h. In contrast, when administered in LNC, 188Re tissue retention was greatly prolonged, with only 10% of the injected dose being eliminated at 72h. Rat median survival was significantly improved for the group treated with 8Gy 188Re-SSS LNC compared to the control group and blank-LNC treated animals. The increase in the median survival time (ISTmedian) was about 80% compared to the control group; 33% of the animals were long-term survivors. The dose of 8Gy proved to be a very effective dose, between toxic (10–12Gy) and ineffective (3–4Gy) doses. Conclusions These findings show that CED of Rhenium-188-loaded lipid nanocapsules is a safe and potent antitumour system for treating malignant gliomas. Our data are the first to show the in vivo efficacy of Rhenium-188 internal radiotherapy for the treatment of brain malignancy. PMID:18465130

Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates

PubMed Central

El-Khouly, Fatma E.; van Vuurden, Dannis G.; Stroink, Thom; Hulleman, Esther; Kaspers, Gertjan J. L.; Hendrikse, N. Harry; Veldhuijzen van Zanten, Sophie E. M.

2017-01-01

Despite decades of clinical trials for diffuse intrinsic pontine glioma (DIPG), patient survival does not exceed 10% at two years post-diagnosis. Lack of benefit from systemic chemotherapy may be attributed to an intact bloodbrain barrier (BBB). We aim to develop a theoretical model including relevant physicochemical properties in order to review whether applied chemotherapeutics are suitable for passive diffusion through an intact BBB or whether local administration via convection-enhanced delivery (CED) may increase their therapeutic potential. Physicochemical properties (lipophilicity, molecular weight, and charge in physiological environment) of anticancer drugs historically and currently administered to DIPG patients, that affect passive diffusion over the BBB, were included in the model. Subsequently, the likelihood of BBB passage of these drugs was ascertained, as well as their potential for intratumoral administration via CED. As only non-molecularly charged, lipophilic, and relatively small sized drugs are likely to passively diffuse through the BBB, out of 51 drugs modeled, only 8 (15%)—carmustine, lomustine, erlotinib, vismodegib, lenalomide, thalidomide, vorinostat, and mebendazole—are theoretically qualified for systemic administration in DIPG. Local administration via CED might create more therapeutic options, excluding only positively charged drugs and drugs that are either prodrugs and/or only available as oral formulation. A wide variety of drugs have been administered systemically to DIPG patients. Our model shows that only few are likely to penetrate the BBB via passive diffusion, which may partly explain the lack of efficacy. Drug distribution via CED is less dependent on physicochemical properties and may increase the therapeutic options for DIPG. PMID:29164054

DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

PubMed

Reddien, Peter W; Andersen, Erik C; Huang, Michael C; Horvitz, H Robert

2007-04-01

The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.

Feasibility of liquid nitrogen cryotherapy after failed radiofrequency ablation for Barrett's esophagus.

PubMed

Trindade, Arvind J; Inamdar, Sumant; Kothari, Shivangi; Berkowitz, Joshua; McKinley, Matthew; Kaul, Vivek

2017-09-01

Radiofrequency ablation (RFA) for dysplastic Barrett's esophagus (BE) is highly effective. RFA failures are infrequent but can be a challenging cohort to manage. There are limited data on the feasibility of liquid nitrogen cryospray ablation for complete eradication of dysplasia (CE-D) and/or intestinal metaplasia (CE-IM) after RFA has failed to achieve CE-IM in patients with dysplastic BE. This is a retrospective review from two medical centers of prospectively maintained databases looking at patients that underwent liquid nitrogen cryospray ablation for refractory intestinal metaplasia post failed RFA. Eighteen patients were identified that met inclusion criteria. Eleven patients had persistent dysplasia and IM following RFA and seven had persistent non-dysplastic IM. More than 80% of patients were male with long-segment BE (median length 8 cm). Seventy two percent of patients with dysplasia achieved CE-D after cryotherapy. Fifty percent (9/18) of all RFA failures achieved CE-IM with cryotherapy. In comparison, RFA has a CE-IM of 78% in a less challenging treatment naïve cohort from a large-scale meta-analysis of 3802 patients. No adverse events occurred in our cohort. Cryospray ablation is feasible and safe for achieving CE-D and CE-IM after RFA failure. The CE-D rates are high with cryotherapy in this population. CE-IM with cryotherapy is acceptable in this difficult-to-treat cohort when compared to CE-IM rates with RFA in dysplastic BE treatment naïve patients (50% vs 78%). © 2017 Japan Gastroenterological Endoscopy Society.

Backflow-free catheters for efficient and safe convection-enhanced delivery of therapeutics.

PubMed

Lueshen, Eric; Tangen, Kevin; Mehta, Ankit I; Linninger, Andreas

2017-07-01

Convection-enhanced delivery (CED) is an invasive drug delivery technique used to target specific regions of the brain for the treatment of cancer and neurodegenerative diseases while bypassing the blood-brain barrier. In order to prevent the possibility of backflow, low volumetric flow rates are applied which limit the achievable drug distribution volumes from CED. This can render CED treatment ineffective since a small convective flow produces narrow drug distribution inside the treatment region. Novel catheter designs and CED protocols are needed to improve the drug distribution inside the treatment region. This is especially important when administering toxic chemotherapeutics which could adversely affect other organs if backflow occurred and these drugs entered the circulating blood stream. In order to help elucidate the causes of backflow and to design backflow-free catheters, we have studied the impact that microfluid flow has on deformable brain phantom gels experimentally as well as numerically. We found that fluid injections into porous media have considerable effects on local transport properties such as porosity and hydraulic conductivity. These phenomena not only alter the bulk flow velocity distribution of the microfluid flow due to the changing porosity, but significantly modify flow direction and even volumetric flow distribution due to induced local hydraulic conductivity anisotropy. These studies led us to the development of novel backflow-free catheters with safe volumetric flow rates up to 10 µL/min. The catheter designs, numerical simulations and experimental results are described throughout this article. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

Intraneural convection enhanced delivery of AAVrh20 for targeting primary sensory neurons.

PubMed

Pleticha, Josef; Jeng-Singh, Christian; Rezek, Rahaf; Zaibak, Manal; Beutler, Andreas S

2014-05-01

Gene therapy using adeno-associated virus (AAV) is an attractive strategy to treat disorders of the peripheral nervous system (PNS), such as chronic pain or peripheral neuropathies. Although intrathecal (IT) administration of AAV has been the standard in the field for targeting the PNS, it lacks anatomical specificity and results in wide rostro-caudal distribution of the vector. An alternative approach is to deliver AAV directly to the peripheral nerve axon. The present study employed convection-enhanced delivery (CED) of a novel AAV serotype, AAVrh20, expressing enhanced green fluorescent protein (EGFP) into rat sciatic nerve investigating its efficacy, anatomical selectivity, and safety, compared to the IT route. Intraneural CED resulted in transduction confined to the ipsilateral L4 and L5 DRG while IT administration led to promiscuous DRG transduction encompassing the entire lumbar region bilaterally. The transduction rate for intraneural AAV administration was similar to IT delivery (24% for L4 and 31.5% for L5 DRG versus 50% for L4 and 19.5% for L5 DRG). The use of hyperosmotic diluent did not further improve the transduction efficiency. AAVrh20 was superior to reference serotypes previously described to be most active for each route. Intraneural CED of AAV was associated with transient allodynia that resolved spontaneously. These findings establish intraneural CED as an alternative to IT administration for AAV mediated gene transfer to the PNS and, based on a reference rodent model, suggest AAVrh20 as a superior serotype for targeting the PNS. Copyright © 2014 Elsevier Inc. All rights reserved.

The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: a report from the Childhood Cancer Survivor Study.

PubMed

Green, Daniel M; Nolan, Vikki G; Goodman, Pamela J; Whitton, John A; Srivastava, DeoKumar; Leisenring, Wendy M; Neglia, Joseph P; Sklar, Charles A; Kaste, Sue C; Hudson, Melissa M; Diller, Lisa R; Stovall, Marilyn; Donaldson, Sarah S; Robison, Leslie L

2014-01-01

Estimation of the risk of adverse long-term outcomes such as second malignant neoplasms and infertility often requires reproducible quantification of exposures. The method for quantification should be easily utilized and valid across different study populations. The widely used Alkylating Agent Dose (AAD) score is derived from the drug dose distribution of the study population and thus cannot be used for comparisons across populations as each will have a unique distribution of drug doses. We compared the performance of the Cyclophosphamide Equivalent Dose (CED), a unit for quantifying alkylating agent exposure independent of study population, to the AAD. Comparisons included associations from three Childhood Cancer Survivor Study (CCSS) outcome analyses, receiver operator characteristic (ROC) curves and goodness of fit based on the Akaike's Information Criterion (AIC). The CED and AAD performed essentially identically in analyses of risk for pregnancy among the partners of male CCSS participants, risk for adverse dental outcomes among all CCSS participants and risk for premature menopause among female CCSS participants, based on similar associations, lack of statistically significant differences between the areas under the ROC curves and similar model fit values for the AIC between models including the two measures of exposure. The CED is easily calculated, facilitating its use for patient counseling. It is independent of the drug dose distribution of a particular patient population, a characteristic that will allow direct comparisons of outcomes among epidemiological cohorts. We recommend the use of the CED in future research assessing cumulative alkylating agent exposure. © 2013 Wiley Periodicals, Inc.

A Pilot Study: Cardiac Parameters in Children Receiving New-Generation Antidepressants.

PubMed

Uchida, Mai; Spencer, Andrea E; Kenworthy, Tara; Chan, James; Fitzgerald, Maura; Rosales, Ana Maria; Kagan, Elana; Saunders, Alexandra; Biederman, Joseph

2017-06-01

Because of concerns about potential associations between high doses of citalopram and QTc prolongation in adults, this study examined whether such associations are operant in children. We hypothesized that therapeutic doses of nontricyclic antidepressant medications (non-TCAs) prescribed to children would be cardiovascularly safe. The sample consisted of 49 psychiatrically referred children and adolescents 6 to 17 years old of both sexes treated with a non-TCA (citalopram, escitalopram, fluoxetine, paroxetine, sertraline, bupropion, duloxetine, venlafaxine, mirtazapine). To standardize the doses of different antidepressants, we converted doses of individual medicines into "citalopram equivalent doses" (CEDs) based on dosing recommendation for individual antidepressants. Correlation analysis was carried out to compare the continuous and weight-based CED to variables of interest. A QTc grouping was defined as normal, borderline, or abnormal, and CED was compared across QTc groupings using linear regression. An antidepressant dosage group was defined as low or high dose, and a t test compared variables of interest across dosage groups. No significant associations were found between total or weight-corrected CEDs of any antidepressant examined and QTc or any other electrocardiogram or blood pressure parameters. In patients taking citalopram or escitalopram, a significant correlation was found between PR interval and total daily dose, which disappeared when weight-based doses were used or when corrected by age. Although limited by a relatively small sample size, these results suggest that therapeutic doses of non-TCA antidepressants when used in children do not seem to be associated with prolonged QTc interval or other adverse cardiovascular effects.

Convection-enhanced delivery of cetuximab conjugated iron-oxide nanoparticles for treatment of spontaneous canine intracranial gliomas.

PubMed

Freeman, A Courtenay; Platt, Simon R; Holmes, Shannon; Kent, M; Robinson, Kelsey; Howerth, Elizabeth; Eagleson, Joe; Bouras, Alexandros; Kaluzova, Milota; Hadjipanayis, Constantinos G

2018-05-01

Cetuximab conjugated iron-oxide nanoparticles (cetuximab-IONPs) have shown both in-vitro and in-vivo anti-tumor efficacy against gliomas. The purpose of this pilot study was to evaluate the safety and potential efficacy of cetuximab-IONPs for treatment of spontaneously occurring intracranial gliomas in canines after convection-enhanced delivery (CED). The use of CED allowed for direct infusion of the cetuximab-IONPs both intratumorally and peritumorally avoiding the blood brain barrier (BBB) and limiting systemic effects. A total of eight dogs participated in the study and only two developed mild post-operative complications, which resolved with medical therapy. All canines underwent a single CED treatment of the cetuximab-IONPs over 3 days and did not receive any further adjuvant treatments. Volumetric analysis showed a median reduction in tumor size of 54.9% by MRI at 1-month (4-6 weeks) follow-up. Five dogs were euthanized due to recurrence of neurological signs other than seizures, two due to recurrent seizures, and one dog died in his sleep. Median survival time after surgery was 248 days (mean 367 days).

Structure of relativistic shocks in pulsar winds: A model of the wisps in the Crab Nebula

NASA Technical Reports Server (NTRS)

Gallant, Yves A.; Arons, Jonathan

1994-01-01

We propose a model of a optical 'wisps' of the Crab Nebula, features observed in the nebular synchrotron surface brightness near the central pulsar, as manifestations of the internal structure of the shock terminating the pulsar wind. We assume that this wind is composed of ions and a much denser plasma of electrons and positrons, frozen together to a toroidal magnetic field and flowing relativistically. We construct a form of solitary wave model of the shock structure in which we self-consistently solve for the ion orbits and the dynamics of the relativistically hot, magnetized e(+/-) background flow. We ignore dispersion in the ion energies, and we treat the pairs as an adiabatic fluid. The synchrotron emission enhancements, observed as the wisps, are then explained as the regions where reflection of the ions in the self-consistent magnetic field causes compressions of the e(+/-).

NGC 6334 V revisited: The complex nature of the infrared nebula

NASA Astrophysics Data System (ADS)

Tapia, M.; Persi, P.; Roth, M.

2017-07-01

A comprehensive analysis is presented of the most recent infrared observations of the small, very young and enigmatic infrared nebula associated with NGC 6334-V. We re-analized images from the Spitzer/IRAC (3.6 a 8 μm), Herschel/SPIRE/PACS (70 a 500 μm), VISTA (1.2 a 2.2 μm), VLT/VISIR (11.3 a 18.7 μm) and HST/NICMOS (2.0 μm) archives. The very high spatial resolution from the latter two sets, combined with very recent sub-millimetre maps, allow us to suggest several possible star-formation scenarios that explain the observed infrared and radio properties of the region. Evidence is provided of the presence of a small population of low and medium-mass young stars embedded in the infrared reflection nebulosity NGC 6334 V that coexist with the nearby much younger Class 0 protostars.

Unveiling Deeply Embedded Sources by Near-Infrared Polarimetric Imaging

NASA Astrophysics Data System (ADS)

Yao, Yongqiang; Ishii, Miki; Nagata, Tetsuya; Nakaya, Hidehiko; Sato, Shuji

2000-10-01

Near-infrared polarimetric images are presented for six molecular outflow sources: IRAS 20050+2720, IRAS 20126+4104, IRAS 20188+3928, S233, AFGL 5180, and AFGL 6366S. All the regions are found to exhibit reflection nebulae and to be associated with massive and clustered star formation. By inspecting polarimetric patterns in the nebulae, we have identified six deeply embedded sources (DESs) which illuminate circumstellar nebulosity but are not detectable in wavelengths shorter than 2 μm. While the DES in IRAS 20050 coincides with an infrared source in a previous, longer wavelength observation and the one in IRAS 20126 with a hot molecular core, the nature of the other newly discovered DESs is not known. From the compilation of the observations of DESs over a large wavelength range, we suspect that the DESs possess characteristics similar to hot molecular cores and are likely to be in the pre-ultracompact H II region phase of massive star formation.

Guidance for Using Formal Methods in a Certification Context

NASA Technical Reports Server (NTRS)

Brown, Duncan; Delseny, Herve; Hayhurst, Kelly; Wiels, Virginie

2010-01-01

This paper discusses some of the challenges to using formal methods in a certification context and describes the effort by the Formal Methods Subgroup of RTCA SC-205/EUROCAE WG-71 to propose guidance to make the use of formal methods a recognized approach. This guidance, expected to take the form of a Formal Methods Technical Supplement to DO-178C/ED-12C, is described, including the activities that are needed when using formal methods, new or modified objectives with respect to the core DO-178C/ED-12C document, and evidence needed for meeting those objectives.

A simulation study to quantify the impacts of exposure ...

EPA Pesticide Factsheets

A simulation study to quantify the impacts of exposure measurement error on air pollution health risk estimates in copollutant time-series models The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

Next-generation concurrent engineering: developing models to complement point designs

NASA Technical Reports Server (NTRS)

Morse, Elizabeth; Leavens, Tracy; Cohanim, Babak; Harmon, Corey; Mahr, Eric; Lewis, Brian

2006-01-01

Concurrent Engineering Design (CED) teams have made routine the rapid development of point designs for space missions. The Jet Propulsion Laboratory's Team X is now evolving into a 'next-generation CED; in addition to a point design, the Team develops a model of the local trade space. The process is a balance between the power of a model developing tools and the creativity of humal experts, enabling the development of a variety of trade models for any space mission. This paper reviews the modeling method and its practical implementation in the ED environment. Example results illustrate the benefit of this approach.

Processing NASA Earth Science Data on Nebula Cloud

NASA Technical Reports Server (NTRS)

Chen, Aijun; Pham, Long; Kempler, Steven

2012-01-01

Three applications were successfully migrated to Nebula, including S4PM, AIRS L1/L2 algorithms, and Giovanni MAPSS. Nebula has some advantages compared with local machines (e.g. performance, cost, scalability, bundling, etc.). Nebula still faces some challenges (e.g. stability, object storage, networking, etc.). Migrating applications to Nebula is feasible but time consuming. Lessons learned from our Nebula experience will benefit future Cloud Computing efforts at GES DISC.

GBT, VLA Team Up to Produce New Image of Orion Nebula

NASA Astrophysics Data System (ADS)

2002-01-01

Combining the best features of the National Science Foundation's (NSF) new Robert C. Byrd Green Bank Telescope (GBT) in West Virginia with those of the NSF's Very Large Array (VLA) in New Mexico, astronomers have produced a vastly improved radio image of the Orion Nebula and developed a valuable new technique for studying star formation and other astrophysical processes. GBT-VLA Image of Orion Nebula GBT-VLA Image of Orion Nebula "Our GBT image of the Orion Nebula is the best image ever produced with a single-dish radio telescope and it illustrates the superb performance of this new telescope," said Debra Shepherd, of the National Radio Astronomy Observatory (NRAO) in Socorro, NM. "By combining data from the GBT with that from the VLA, we get an image that reflects reality far better than images from the separate telescopes could do," she added. Shepherd worked with Ron Maddalena from NRAO in Green Bank and Joe McMullin, from NRAO in Socorro. The astronomers presented their work to the American Astronomical Society meeting in Washington, DC. Single-dish radio telescopes such as the GBT, dedicated in 2000, are able to capture the large-scale structure of objects such as the Orion Nebula. However, they are unable to discern the fine detail revealed by multi-antenna arrays such as the VLA. Conversely, a VLA-like array is "blind" to the larger-scale structures. Combining the data from both types of radio telescopes to produce an image showing both large- and small-scale structures in the same celestial object has been a difficult, laborious task. "We are developing new observing techniques and software to make this task much easier and quicker," said McMullin. "We now have achieved in hours what used to take months or even longer to do, but we are producing an observational tool that will allow astronomers to make much higher-fidelity images that will greatly improve our understanding of several important astronomical processes," McMullin added. For this observation, both the individual images from each telescope as well as the combined image were produced using the AIPS++ (Astronomical Information Processing System) software, developed, in part, by NRAO. The observers worked with Tim Cornwell, NRAO's Associate Director for Data Management, to develop the techniques used to combine the images. The Orion Nebula, easily visible in amateur telescopes, is a giant cloud of gas some 1,500 light-years away in which new stars are forming. The GBT-VLA radio image, Shepherd said, shows new details that will allow scientists to better understand how ionized gas near the young, hot stars at the nebula's center flows outward toward the edge of the nebula. The ability to produce combined GBT-VLA images also may revise scientists' understanding of other objects. For example, says NRAO Director Paul Vanden Bout, "Astronomers have seen many pockets of ionized Hydrogen gas in star-forming clouds with the VLA that are thought to be ultra-compact. It may be that they are, in fact, larger than thought and, using the GBT in addition to the VLA will show us the true picture." The importance of this observing technique lies in its ability to greatly improve the fidelity of images. "By fidelity we mean how closely the image actually reflects reality. We now have a powerful new tool for improving the fidelity of our images when we look at objects that are close enough to appear relatively large in the sky but which also contain fine detail within the larger structure," Shepherd said. "This will have a big impact on a number of research areas such as star formation in our Galaxy, planetary nebulae, supernova remnants, as well as dynamics and star formation in near-by galaxies," she added. The new technique also paves the way for effective use of the Expanded VLA, which will incorporate state-of-the-art electronics and digital equipment to replace now-aging technologies dating from the VLA's construction in the 1970s. In addition, the new capabilities can be used with the Atacama Large Millimeter Array (ALMA), a millimeter-wave observatory to be constructed in Chile as a partnership among North American, European and Japanese astronomers. The combined GBT-VLA image was produced from observations made at a radio frequency of 8.4 GHz. The VLA observations were made in 2000 and the GBT observations in November of 2001. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

Regional convection-enhanced delivery of gadolinium-labeled albumin in the rat hippocampus in vivo.

PubMed

Astary, Garrett W; Kantorovich, Svetlana; Carney, Paul R; Mareci, Thomas H; Sarntinoranont, Malisa

2010-03-15

Convection-enhanced delivery (CED) has emerged as a promising method of targeted drug delivery for treating central nervous system (CNS) disorders, but the influence of brain structure on infusate distribution is unclear. We have utilized this approach to study extracellular transport and distribution of a contrast agent in the hippocampus, a complex structure susceptible to CNS disorders. The magnetic resonance (MR) contrast agent diethylene triamene penta-acetic acid chelated gadolinium-labeled albumin (Gd-albumin), tagged with Evans blue dye, was directly infused (V(i)=5 microl) into the dorsal and ventral hippocampus of seven male Sprague-Dawley rats. The final distribution profile of the contrast agent, a product of CED and limited diffusion, was observed in vivo using high-resolution T1-weighted MR imaging at 11.1T. Dense cell layers, such as the granule cell layer of the dentate gyrus and the pyramidal cell layer of CA1, appeared to be barriers to transport of the tracer. Three-dimensional distribution shape and volume (V(d)) differences, between the dorsal and ventral hippocampus infusions, were determined from the MR images using a semi-automatic segmentation routine (dorsal V(d)=23.4+/-1.8 microl, ventral V(d)=36.4+/-5.1 microl). Finer structural detail of the hippocampus was obtained using a combination of histological analysis and fluorescence imaging. This study demonstrates that CED has the potential to target all regions of the hippocampus and that tracer distribution is influenced by infusion site, underlying structure and circuitry, and extent of backflow. Therefore, CED, combined with high-resolution MR imaging, may be a useful strategy for delivering therapeutics for the treatment of CNS disorders affecting the hippocampus. Published by Elsevier B.V.

Cumulative effective dose associated with computed tomography examinations in adolescent trauma patients.

PubMed

Choi, Seung Joon; Kim, Eun Young; Kim, Hyung Sik; Choi, Hye-Young; Cho, Jinseong; Yang, Hyuk Jun; Chung, Yong Eun

2014-07-01

The aims of this study were to analyze cumulative effective dose (cED) and to assess lifetime attributable risk (LAR) of cancer due to radiation exposure during computed tomography (CT) examinations in adolescent trauma patients. Between January 2010 and May 2011, the adolescent patients with trauma were enrolled in this study. Numbers of CT examinations and body regions examined were collated, and cEDs were calculated using dose-length product values and conversion factors. Lifetime attributable risk for cancer incidence and cancer-associated mortality were quantified based on the studies of survivors of the atomic bombs on Japan. Data were stratified according to severity of trauma: minor trauma, injury severity score of less than 16; and major trauma, injury severity score of 16 or greater. A total of 698 CT scans were obtained on the following regions of 484 adolescent patients: head CT, n = 647; rest of the body, n = 41; and thorax, n = 10. Mean cED per patient was 3.4 mSv, and mean LARs for cancer incidence and mortality were 0.05% and 0.02%, respectively. The majority of patients (98.4%) experienced minor trauma, and their mean cED and LARs for cancer incidence and mortality (3.0 mSv and 0.04% and 0.02%, respectively) were significantly lower than those of patients with major trauma (24.3 mSv and 0.31% and 0.15%, respectively, all P values < 0.001). The overall radiation-induced cancer risk due to CT examinations performed for the initial assessment of minor trauma was found to be relatively low in adolescent patients. However, adolescent patients with major trauma were exposed to a substantial amount of radiation during multiple CT examinations.

Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain

PubMed Central

van der Bom, Imramsjah M J; Moser, Richard P; Gao, Guanping; Sena-Esteves, Miguel; Aronin, Neil

2013-01-01

Introduction Convection-enhanced delivery (CED) has been shown to be an effective method of administering macromolecular compounds into the brain that are unable to cross the blood-brain barrier. Because the administration is highly localized, accurate cannula placement by minimally invasive surgery is an important requisite. This paper reports on the use of an angiographic c-arm system which enables truly frameless multimodal image guidance during CED surgery. Methods A microcannula was placed into the striatum of five sheep under real-time fluoroscopic guidance using imaging data previously acquired by cone beam computed tomography (CBCT) and MRI, enabling three-dimensional navigation. After introduction of the cannula, high resolution CBCT was performed and registered with MRI to confirm the position of the cannula tip and to make adjustments as necessary. Adeno-associated viral vector-10, designed to deliver small-hairpin micro RNA (shRNAmir), was mixed with 2.0 mM gadolinium (Gd) and infused at a rate of 3 μl/min for a total of 100 μl. Upon completion, the animals were transferred to an MR scanner to assess the approximate distribution by measuring the volume of spread of Gd. Results The cannula was successfully introduced under multimodal image guidance. High resolution CBCT enabled validation of the cannula position and Gd-enhanced MRI after CED confirmed localized administration of the therapy. Conclusion A microcannula for CED was introduced into the striatum of five sheep under multimodal image guidance. The non-alloy 300 μm diameter cannula tip was well visualized using CBCT, enabling confirmation of the position of the end of the tip in the area of interest. PMID:22193239

Development of coverage with evidence development for medical technologies in Switzerland from 1996 to 2012.

PubMed

Brügger, Urs; Ruckstuhl, Andreas; Horisberger, Bruno; Gratwohl, Alois

2014-07-01

The aim of this study was to assess incidence, time frame, and outcome of "Coverage with Evidence Development" (CED) decisions in the Swiss Basic Health Insurance scheme. Analysis of all controversial medical technologies submitted to review by the Swiss Federal Office of Public Health (FOPH) from 1996 to 2012 with focus on decisions with constraints. Description of types of technology, type of initial decision, duration of evaluation period, final decision, and search for potential factors associated with changes over time. Forty-five (37.5 percent) of 120 controversial health technologies were classified as "yes, in evaluation, reimbursed" for a certain period of time and thirty-five (29.2 percent) as "no, in evaluation, not reimbursed" by the Federal Department of Home Affairs from 1996 to 2012. The rate of CED decisions ranged between zero and nine per year and was influenced by type of technology and calendar year. Forty-four of forty-five decisions were subject to further restrictions, to a "center or a specialist" (76 percent), "indications" (49 percent), "registry" (31 percent), or "other" (49 percent). The time to a final decision ranged from 1.5 to 11 years (median, 6 years). No factors associated with initial decision and final outcome could be identified. CED as a reality in Switzerland might have enabled patients to obtain access to promising technologies early in their life cycle. CED might have acted as a trigger to a successful implementation of a comprehensive national registry. The lack of qualitative data stresses the urgent need for evaluation of the HTA decisions and their impact on patient outcome and costs.

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis.

PubMed

Golko-Perez, Sagit; Mandel, Silvia; Amit, Tamar; Kupershmidt, Lana; Youdim, Moussa B H; Weinreb, Orly

2016-02-01

Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motoneuron system, involving various abnormalities, such as mitochondrial dysfunction, oxidative stress, transitional metal accumulation, neuroinflammation, glutamate excitotoxicity, apoptosis, decreased supply of trophic factors, cytoskeletal abnormalities, and extracellular superoxide dismutase (SOD)-1 toxicity. These multiple disease etiologies implicated in ALS gave rise to the perception that future therapeutic approaches for the disease should be aimed at targeting multiple pathological pathways. In line with this view, we have evaluated in the current study the therapeutic effects of low doses of the novel multifunctional monoamine oxidase (MAO) inhibitor/iron-chelating compound, M30 in combination with high Calorie Energy supplemented Diet (CED) in the SOD1-G93A transgenic mouse model of ALS. Our results demonstrated that the combined administration of M30 with CED produced additive neuroprotective effects on motor performance and increased survival of SOD1-G93A mice. We also found that both M30 and M30/CED regimens caused a significant inhibition of MAO-A and -B activities and decreased the turnover of dopamine in the brain of SOD1-G93A mice. In addition, M30/CED combined treatment resulted in a significant increase in mRNA expression levels of various mitochondrial biogenesis and metabolism regulators, such as peroxisome proliferator-activated receptor-γ (PPARγ)-co activator 1 alpha (PGC-1α), PPARγ, uncoupling protein 1, and insulin receptor in the gastrocnemius muscle of SOD1-G93A mice. These results suggest that a combination of drug/agents with different, but complementary mechanisms may be beneficial in the treatment of ALS.

Poor diagnostic accuracy of a single fasting plasma citrulline concentration to assess intestinal energy absorption capacity.

PubMed

Peters, Job H C; Wierdsma, Nicolette J; Teerlink, Tom; van Leeuwen, Paul A M; Mulder, Chris J J; van Bodegraven, Ad A

2007-12-01

Our aim was to explore the diagnostic value of fasting citrulline concentrations to detect decreased intestinal energy absorption in patients with recently diagnosed celiac disease (CeD), refractory celiac disease (RCeD), and short bowel syndrome (SBS). Decreased intestinal energy absorption is regarded a marker of intestinal failure. Fasting plasma citrulline concentrations were determined by high performance liquid chromatography (HPLC) in a prospective study of 30 consecutive adult patients (15 CeD, 9 RCeD, and 16 SBS) and 21 healthy subjects. Intestinal energy absorption capacity using bomb calorimetry was determined in all patients and healthy subjects and was regarded as the gold standard for intestinal energy absorption function. The mean fasting plasma citrulline concentration was lower in RCeD patients than in healthy subjects (28.5+/-9.9 vs 38.1+/-8.0 micromol/L, P<0.05) and CeD patients (28.5+/-9.9 vs 38.1+/-6.4 micromol/L, P<0.05), however, clearly within reference values. The mean intestinal energy absorption capacity was lower in SBS patients than in healthy subjects (64.3+/-18.2 vs 90.3+/-3.5%, P<0.001), CeD patients (64.3+/-18.2 vs 89.2+/-3.4%, P<0.001), and the RCeD group (64.3+/-18.2 vs 82.3+/-11.7%, P<0.01). No relation was observed between fasting plasma citrulline concentration and intestinal energy absorption capacity (Pearson r=0.09, P=0.56). The area under the ROC curve for fasting plasma citrulline to detect decreased intestinal energy absorption capacity (i.e., <85%) was 0.50. Fasting plasma citrulline concentrations have poor test characteristics for detection of decreased intestinal energy absorption capacity in patients with enterocyte damage.

146Sm-142Nd systematics measured in enstatite chondrites reveals a heterogeneous distribution of 142Nd in the solar nebula.

PubMed

Gannoun, Abdelmouhcine; Boyet, Maud; Rizo, Hanika; El Goresy, Ahmed

2011-05-10

The short-lived (146)Sm-(142)Nd chronometer (T(1/2) = 103 Ma) is used to constrain the early silicate evolution of planetary bodies. The composition of bulk terrestrial planets is then considered to be similar to that of primitive chondrites that represent the building blocks of rocky planets. However for many elements chondrites preserve small isotope differences. In this case it is not always clear to what extent these variations reflect the isotope heterogeneity of the protosolar nebula rather than being produced by the decay of parent isotopes. Here we present Sm-Nd isotopes data measured in a comprehensive suite of enstatite chondrites (EC). The EC preserve (142)Nd/(144)Nd ratios that range from those of ordinary chondrites to values similar to terrestrial samples. The EC having terrestrial (142)Nd/(144)Nd ratios are also characterized by small (144)Sm excesses, which is a pure p-process nuclide. The correlation between (144)Sm and (142)Nd for chondrites may indicate a heterogeneous distribution in the solar nebula of p-process matter synthesized in supernovae. However to explain the difference in (142)Nd/(144)Nd ratios, 20% of the p-process contribution to (142)Nd is required, at odds with the value of 4% currently proposed in stellar models. This study highlights the necessity of obtaining high-precision (144)Sm measurements to interpret properly measured (142)Nd signatures. Another explanation could be that the chondrites sample material formed in different pulses of the lifetime of asymptotic giant branch stars. Then the isotope signature measured in SiC presolar would not represent the unique s-process signature of the material present in the solar nebula during accretion.

146Sm–142Nd systematics measured in enstatite chondrites reveals a heterogeneous distribution of 142Nd in the solar nebula

PubMed Central

Gannoun, Abdelmouhcine; Boyet, Maud; Rizo, Hanika; El Goresy, Ahmed

2011-01-01

The short-lived 146Sm–142Nd chronometer (T1/2 = 103 Ma) is used to constrain the early silicate evolution of planetary bodies. The composition of bulk terrestrial planets is then considered to be similar to that of primitive chondrites that represent the building blocks of rocky planets. However for many elements chondrites preserve small isotope differences. In this case it is not always clear to what extent these variations reflect the isotope heterogeneity of the protosolar nebula rather than being produced by the decay of parent isotopes. Here we present Sm–Nd isotopes data measured in a comprehensive suite of enstatite chondrites (EC). The EC preserve 142Nd/144Nd ratios that range from those of ordinary chondrites to values similar to terrestrial samples. The EC having terrestrial 142Nd/144Nd ratios are also characterized by small 144Sm excesses, which is a pure p-process nuclide. The correlation between 144Sm and 142Nd for chondrites may indicate a heterogeneous distribution in the solar nebula of p-process matter synthesized in supernovae. However to explain the difference in 142Nd/144Nd ratios, 20% of the p-process contribution to 142Nd is required, at odds with the value of 4% currently proposed in stellar models. This study highlights the necessity of obtaining high-precision 144Sm measurements to interpret properly measured 142Nd signatures. Another explanation could be that the chondrites sample material formed in different pulses of the lifetime of asymptotic giant branch stars. Then the isotope signature measured in SiC presolar would not represent the unique s-process signature of the material present in the solar nebula during accretion. PMID:21515828

The Diffuse Interstellar Bands: Contributed papers

NASA Technical Reports Server (NTRS)

Tielens, Alexander G. G. M. (Editor)

1994-01-01

Drawing a coherent picture of the observational characteristics of the Diffuse Interstellar Bands (DIB's) and the physical and chemical properties of its proposed carriers was the focus of this NASA sponsored conference. Information relating to absoption spectra, diffuse radiation carriers, carbon compounds, stellar composition, and interstellar extinction involving T-Tauri stars, Reflection Nebulae, Red Giants, and accretion discs are discussed from those papers presented at the conference, which are included in this analytic.

AmeriFlux US-Ced Cedar Bridge

DOE Data Explorer

Clark, Ken [USDA Forest Service

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Ced Cedar Bridge. Site Description - Wildfires and prescribed fires are a common occurrence in the NJ Pinelands. Prior to a 1995 nonstand replacing wildfire, the stand was last burned in the very large wildfire in 1963. Plow lines were installed for fire control in December of 2007, followed by a prescribed burns in 2008 and 2013, conducted by the New Jersey Forest Fire Service. Pine looper defoliated the stand in 1998, and Gypsy moth defoliated the understory and deciduos oaks in 2007. Pitch Pines are largely unaffected by defoliation by Gypsy moth.

Supporting clinical engineering in Italy: results of a survey conducted by the AIIC.

PubMed

Faggiano, Francesco; Ritrovato, Matteo; Freda, Paola; Vivo, Liliana; D'Alessandro, Luigi; Derrico, Pietro

2012-01-01

This article presents the outcomes of a survey developed and conducted by the Italian Association of Clinical Engineers (AIIC) in 2010 [1]. The AIIC, affiliated with the International Federation for Medical and Biological Engineering (IFMBE) since 2003, conducted this in-depth survey to investigate the educational profile of clinical engineers (CEs) as well as the activities and organization of clinical engineering departments (CEDs) in Italy. The survey consisted of a six-section questionnaire designed by the AIIC Board, which was based on other previous international surveys of CEDs. The questionnaire was sent to the AIIC members and to the most important Italian health-care organizations.

Reaction of. beta. -propiolactone with derivatives of adenine and with DNA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, R.; Mieyal, J.J.; Goldthwait, D.A.

1982-01-01

The reaction of deoxyadenosine with ..beta..-propiolactone produces two derivatives. One is 1-(2-carboxyethyl)-2-deoxyadenosine (CEdA). The proposed structure for the other is 3-(..beta..-D-2-deoxyribosyl)-7,8-dihydropyrimido-(2,l-i)purine-9-one (dDPP). Spectral characteristics of both compounds are presented. These include u.v. spectra of each in acidic, neutral and alkaline solutions, i.r. spectra, fluorescence spectra, and n.m.r. spectra. The dDPP can be converted to CEdA by mild acid hydrolysis, and the CEdA can be converted to dDPP by reaction with a carbodiimide derivative. When poly A was reacted with ..beta..-propiolactone, the yield of dDPP in the polymer was 7-9%. When double-stranded DNA was alkylated by (/sup 3/H)..beta..-propiolactone at relatively highmore » concentrations and then acid hydrolyzed to separate 1-(2-carboxyethyl)adenine (CEA) and 7-(2-carboxyethyl)guanine (CEG), and CEA to CEG ratio of up to 0.62 was obtained. With relatively low concentrations of (/sup 3/H)..beta..-propiolactone, the yield of CEA was low with double-stranded DNA but was 5-6 fold greater with single-stranded DNA.« less

Toxicity evaluation of convection-enhanced delivery of small-molecule kinase inhibitors in naïve mouse brainstem.

PubMed

Zhou, Zhiping; Ho, Sharon L; Singh, Ranjodh; Pisapia, David J; Souweidane, Mark M

2015-04-01

Diffuse intrinsic pontine gliomas (DIPGs) are inoperable and lethal high-grade gliomas lacking definitive therapy. Platelet-derived growth factor receptor (PDGFR) and its downstream signaling molecules are the most commonly overexpressed oncogenes in DIPG. This study tested the effective concentration of PDGFR pathway inhibitors in cell culture and then toxicity of these small-molecule kinase inhibitors delivered to the mouse brainstem via convection-enhanced delivery (CED) for potential clinical application. Effective concentrations of small-molecule kinase inhibitors were first established in cell culture from a mouse brainstem glioma model. Sixteen mice underwent CED, a local drug delivery technique, of saline or of single and multidrug combinations of dasatinib (2 M), everolimus (20 M), and perifosine (0.63 mM) in the pons. Animals were kept alive for 3 days following the completion of infusion. No animals displayed any immediate or delayed neurological deficits postoperatively. Histological analysis revealed edema, microgliosis, acute inflammation, and/or axonal injury in the experimental animals consistent with mild acute drug toxicity. Brainstem CED of small-molecule kinase inhibitors in the mouse did not cause serious acute toxicities. Future studies will be necessary to evaluate longer-term safety to prepare for potential clinical application.

Using additional external inputs to forecast water quality with an artificial neural network for contamination event detection in source water

NASA Astrophysics Data System (ADS)

Schmidt, F.; Liu, S.

2016-12-01

Source water quality plays an important role for the safety of drinking water and early detection of its contamination is vital to taking appropriate countermeasures. However, compared to drinking water, it is more difficult to detect contamination events because its environment is less controlled and numerous natural causes contribute to a high variability of the background values. In this project, Artificial Neural Networks (ANNs) and a Contamination Event Detection Process (CED Process) were used to identify events in river water. The ANN models the response of basic water quality sensors obtained in laboratory experiments in an off-line learning stage and continuously forecasts future values of the time line in an on-line forecasting step. During this second stage, the CED Process compares the forecast to the measured value and classifies it as regular background or event value, which modifies the ANN's continuous learning and influences its forecasts. In addition to this basic setup, external information is fed to the CED Process: A so-called Operator Input (OI) is provided to inform about unusual water quality levels that are unrelated to the presence of contamination, for example due to cooling water discharge from a nearby power plant. This study's primary goal is to evaluate how well the OI fits into the design of the combined forecasting ANN and CED Process and to understand its effects on the online forecasting stage. To test this, data from laboratory experiments conducted previously at the School of Environment, Tsinghua University, have been used to perform simulations highlighting features and drawbacks of this method. Applying the OI has been shown to have a positive influence on the ANN's ability to handle a sudden change in background values, which is unrelated to contamination. However, it might also mask the presence of an event, an issue that underlines the necessity to have several instances of the algorithm run in parallel. Other difficulties addressed in this study include the source and the format of the OI. This project tries to add to the ongoing research into algorithms for CED. It provides ideas for how results from the binary classification of time series could be evaluated in a more realistic fashion and shows what the advantages and limitations of such a method would be.

SYNCHROTRON HEATING BY A FAST RADIO BURST IN A SELF-ABSORBED SYNCHROTRON NEBULA AND ITS OBSERVATIONAL SIGNATURE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Yuan-Pei; Dai, Zi-Gao; Zhang, Bing, E-mail: zhang@physics.unlv.edu

Fast radio bursts (FRBs) are mysterious transient sources. If extragalactic, as suggested by their relative large dispersion measures, their brightness temperatures must be extremely high. Some FRB models (e.g., young pulsar model, magnetar giant flare model, or supra-massive neutron star collapse model) suggest that they may be associated with a synchrotron nebula. Here we study a synchrotron-heating process by an FRB in a self-absorbed synchrotron nebula. If the FRB frequency is below the synchrotron self-absorption frequency of the nebula, electrons in the nebula would absorb FRB photons, leading to a harder electron spectrum and enhanced self-absorbed synchrotron emission. In themore » meantime, the FRB flux is absorbed by the nebula electrons. We calculate the spectra of FRB-heated synchrotron nebulae, and show that the nebula spectra would show a significant hump in several decades near the self-absorption frequency. Identifying such a spectral feature would reveal an embedded FRB in a synchrotron nebula.« less

GHOSTLY REFLECTIONS IN THE PLEIADES

NASA Technical Reports Server (NTRS)

2002-01-01

NASA's Hubble Space Telescope has caught the eerie, wispy tendrils of a dark interstellar cloud being destroyed by the passage of one of the brightest stars in the Pleiades star cluster. Like a flashlight beam shining off the wall of a cave, the star is reflecting light off the surface of pitch black clouds of cold gas laced with dust. These are called reflection nebulae. The famous cluster is easily visible in the evening sky during the winter months as a small grouping of bright blue stars, named after the 'Seven Sisters' of Greek mythology. Resembling a small dipper, this star cluster lies in the constellation Taurus at a distance of about 380 light-years from Earth. The unaided eye can discern about half a dozen bright stars in the cluster, but a small telescope will reveal that the Pleiades contains many hundreds of fainter stars. In many cases, the nebulae surrounding star clusters represent material from which the stars have formed recently. However the Pleiades nebulosity is actually an independent cloud, drifting through the cluster at a relative speed of about 6.8 miles/second (11 kilometers/second). In 1890, American astronomer E. E. Barnard, observing visually with the Lick Observatory 36-inch telescope in California, discovered an exceptionally bright nebulosity adjacent to the bright Pleiades star Merope. It is now cataloged as IC 349, or 'Barnard's Merope Nebula.' IC 349 is so bright because it lies extremely close to Merope--only about 3,500 times the separation of the Earth from the Sun, or about 0.06 light-year--and thus is strongly illuminated by the star's light. In the new Hubble image, Merope itself is just outside the frame on the upper right. The colorful rays of light at the upper right, pointing back to the star, are an optical phenomenon produced within the telescope, and are not real. However, the remarkable parallel wisps extending from lower left to upper right are real features, revealed for the first time through Hubble's high-resolution imaging capability. Astronomers George Herbig and Theodore Simon of the University of Hawaii obtained these broadband observations with Hubble's Wide Field and Planetary Camera 2 on September 19, 1999. Herbig and Simon propose that, as the Merope Nebula approaches Merope, the strong starlight shining on the dust decelerates the dust particles. Physicists call this phenomenon 'radiation pressure.' Smaller dust particles are slowed down more by the radiation pressure than the larger particles. Thus, as the cloud approaches the star, there is a sifting of particles by size, much like grain thrown in the air to separate wheat from chaff. The nearly straight lines pointing toward Merope are thus streams of larger particles, continuing on toward the star while the smaller decelerated particles are left behind at the lower left of the picture. Over the next few thousand years, the nebula--if it survives the close passage without being completely destroyed--will move on past Merope, somewhat like a comet swinging past our Sun. This chance collision allows astronomers to study interstellar material under very rare conditions, and thus learn more about the structure of the dust lying between the stars. Image Credit: NASA and The Hubble Heritage Team (STScI/AURA) Acknowledgment: George Herbig and Theodore Simon (Institute for Astronomy, University of Hawaii)

Kinetics of Methane Clathrate Formation in the Presolar Nebula

NASA Astrophysics Data System (ADS)

Vu, Tuan; Choukroun, Mathieu

2016-10-01

Clathrate hydrates are a distinct form of water ice wherein the crystal lattice of the host water molecules forms symmetric, polyhedral cages that trap volatile guest species under appropriate pressures and temperatures. These materials are an abundant source of hydrocarbons on Earth, and have been expected to be present on a number of icy celestial bodies, including Mars, Europa, Titan, and Enceladus. Clathrates are also thought to be one of the most likely traps for volatiles during the condensation of the protostellar nebulae. Prior to the Voyager mission, the prevailing expectation was that the elemental composition of the giant planets would reflect the composition of the solar nebula and therefore be similar to solar abundances. However, spacecraft observations by Voyager, Galileo, and Cassini-Huygens, as well as ground-based observations, have revealed unexpected elemental enrichment, relative to solar abundances, of C, N, S, As, P, and noble gases in the giant planets and in comets. One of the contending explanations is the retention of these volatiles as clathrate hydrates, which may have enabled their capture early in the history of the Solar System.While the formation and stability of clathrates have been addressed theoretically and, to some extent, experimentally at relatively high pressures (10-7-10-3 bar), there is a scarcity of experimental undertaking on the kinetics of clathrate formation and their stability at the low pressures relevant to the early outer solar nebula (~10-11 bar). This study seeks to elucidate the clathrate formation kinetics under nebula-relevant conditions via a series of optical Raman experiments on ice/gas mixtures over a range of pressures and temperatures. Our work on the methane gas/ice system shows that clathrate formation occurs on a rather fast timescale (typically within minutes at 223-253 K and 30-50 bar CH4). In addition, the rate of enclathration increases with pressures and temperatures, and the activation energy for clathrate growth is found to be comparable to those for gas diffusion through ice. These results suggest that the energy barrier for clathrate formation is quite low, implying the likelihood of existence of these materials under nebular conditions.

A Precessing Jet in a Dying Star: Adaptive Optics Imaging of the ``Water-Fountain" Nebula IRAS16342-3814

NASA Astrophysics Data System (ADS)

Sahai, R.; Le Mignant, D.; Sánchez Contreras, C.; Campbell, R. D.; Chaffee, F. H.

2004-12-01

Collimated jets are one of the most intriguing, yet poorly understood phenomena in astrophysics. Jets have been found in a wide variety of object classes which include active galactic nuclei, young stellar objects, massive X-ray binaries, black hole X-ray transients, symbiotic stars, supersoft X-ray sources, and finally, planetary and preplanetary nebulae (PNe & PPNe). In the case of PNe and PPNe, it has been proposed that wobbling collimated jets may be the universal mechanism which can explain a wide variety of bipolar and multipolar morphologies seen in these objects (Sahai 2000, ASP Conf.Ser. 199, 209). The ``Water-Fountain Nebula'', IRAS16342-3814 (IRAS1634) belongs to a class of very young PPNe with high-velocity molecular outflows traced in either or both of radio H2O and OH maser line emission, and are believed to result from the interaction of fast jets with ambient circumstellar material shed by the AGB progenitors of these objects. Hubble Space Telescope (HST) imaging of IRAS1634 showed a small bipolar nebula, with the lobes separated by a dark equatorial waist (Sahai et al. 1999, ApJ, 514, L115) -- the morphology was interpreted as bubble-like reflection nebulae illuminated by starlight escaping through polar holes in a dense, dusty waist obscuring the central star, with the bubbles created by a fast jet-like outflow plowing into the AGB mass-loss envelope. Here we report Adaptive Optics (AO) observations with the W. M. Keck Observatory at near-infrared wavelengths (in the H, K', L', Ms bands) which probe much deeper into the lobes and reveal a remarkable corkscrew-shaped structure apparently etched into the lobe walls. The corkscrew structure represents the proverbial ``writing on the wall" signature of an underlying precessing jet, and we compare our results with predictions from published numerical simulations of such jets. The results shown provide a dramatic example of the power of ground-based AO imaging with large telescopes to uncover phenomena which are hidden even to the sharp eyes of HST.

A Photometrically and Morphologically Variable Infrared Nebula IN L483

NASA Astrophysics Data System (ADS)

Connelley, Michael S.; Hodapp, Klaus W.; Fuller, Gary A.

2009-03-01

We present narrow and broad K-band observations of the Class 0/I source IRAS 18148-0440 that span 17 years. The infrared nebula associated with this protostar in the L483 dark cloud is both morphologically and photometrically variable on a timescale of only a few months. This nebula appears to be an infrared analog to other well known optically visible variable nebulae associated with young stars, such as Hubble's Variable Nebula. Along with Cepheus A, this is one of the first large variable nebulae to be found that is only visible in the infrared. The variability of this nebula is most likely due to changing illumination of the cloud rather than any motion of the structure in the nebula. Both morphological and photometric changes are observed on a timescale only a few times longer than the light crossing time of the nebula, suggesting very rapid intrinsic changes in the illumination of the nebula. Our narrowband observations also found that H2 knots are found nearly twice as far to the east of the source as to its west, and that H2 emission extends farther east of the source than the previously known CO outflow.

NICMOS PEERS INTO HEART OF DYING STAR

NASA Technical Reports Server (NTRS)

2002-01-01

The Egg Nebula, also known as CRL 2688, is shown on the left as it appears in visible light with the Hubble Space Telescope's Wide Field and Planetary Camera 2 (WFPC2) and on the right as it appears in infrared light with Hubble's Near Infrared Camera and Multi-Object Spectrometer (NICMOS). Since infrared light is invisible to humans, the NICMOS image has been assigned colors to distinguish different wavelengths: blue corresponds to starlight reflected by dust particles, and red corresponds to heat radiation emitted by hot molecular hydrogen. Objects like the Egg Nebula are helping astronomers understand how stars like our Sun expel carbon and nitrogen -- elements crucial for life -- into space. Studies on the Egg Nebula show that these dying stars eject matter at high speeds along a preferred axis and may even have multiple jet-like outflows. The signature of the collision between this fast-moving material and the slower outflowing shells is the glow of hydrogen molecules captured in the NICMOS image. The distance between the tip of each jet is approximately 200 times the diameter of our solar system (out to Pluto's orbit). Credits: Rodger Thompson, Marcia Rieke, Glenn Schneider, Dean Hines (University of Arizona); Raghvendra Sahai (Jet Propulsion Laboratory); NICMOS Instrument Definition Team; and NASA Image files in GIF and JPEG format and captions may be accessed on the Internet via anonymous ftp from ftp.stsci.edu in /pubinfo.

RADIO POLARIZATION OBSERVATIONS OF THE SNAIL: A CRUSHED PULSAR WIND NEBULA IN G327.1–1.1 WITH A HIGHLY ORDERED MAGNETIC FIELD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Y. K.; Ng, C.-Y.; Bucciantini, N.

2016-04-01

Pulsar wind nebulae (PWNe) are suggested to be acceleration sites of cosmic rays in the Galaxy. While the magnetic field plays an important role in the acceleration process, previous observations of magnetic field configurations of PWNe are rare, particularly for evolved systems. We present a radio polarization study of the “Snail” PWN inside the supernova remnant G327.1−1.1 using the Australia Telescope Compact Array. This PWN is believed to have been recently crushed by the supernova (SN) reverse shock. The radio morphology is composed of a main circular body with a finger-like protrusion. We detected a strong linear polarization signal frommore » the emission, which reflects a highly ordered magnetic field in the PWN and is in contrast to the turbulent environment with a tangled magnetic field generally expected from hydrodynamical simulations. This could suggest that the characteristic turbulence scale is larger than the radio beam size. We built a toy model to explore this possibility, and found that a simulated PWN with a turbulence scale of about one-eighth to one-sixth of the nebula radius and a pulsar wind filling factor of 50%–75% provides the best match to observations. This implies substantial mixing between the SN ejecta and pulsar wind material in this system.« less

Late Neoproterozoic basement rocks of Meatiq area, Central Eastern Desert, Egypt: Petrography and remote sensing characterizations

NASA Astrophysics Data System (ADS)

Hassan, Safaa M.; El kazzaz, Yahiya A.; Taha, Maysa M. N.; Mohammad, Abdullah T.

2017-07-01

Meatiq dome is one of the mysteries of the basement rocks in Central Eastern Desert (CED) of Egypt. Its mode of formation, and tectonic evolution are still controversial and not fully understood. Satellite remote sensing is a powerful tool for geologic applications, especially in inaccessible regions of the Earth's surface. In this study, three proposed Landsat-8 band ratios (6/2, 6/7, (6/4*4/3)), (6/7, 6/4, 4/2), and (7/5, 7/6, 5/3) are successfully used for detailed geological mapping of the different lithological rock units exposed in Meatiq dome area in the CED. Landsat-8 Principal component (PC) images is also used for refinement the boundaries between the widely-exposed rock units in the study area. Fourteen spectral bands of Advanced Space borne Thermal Emission and Reflection Radiometer (ASTER) data are successfully used to emphasize the distribution of some rock forming minerals (i.e. muscovite, quartz, ferrous oxides, ferrous silicates and hydroxyl-bearing minerals) in the lithological rock units of Meatiq dome area. ASTER muscovite index (B7/B6) and quartz index (B14/B12), ferrous iron index (B5/B3), ferrous silicates index (B5/B4), mafic index (B12/B13) and hydroxyl-bearing minerals index ((B7/B6)*(B4/B6)) discriminate muscovite bearing rocks, Granitoids, and other felsic rocks, amphibolite and other mafic rocks. The proposed image processing methods effectively discriminates between four granitic varieties existed in Meatiq area. They are namely; Abu Ziran, Ariki, Fawakhir and Atalla Plutons. This study reveals that the applied data of ASTER and Landsat-8 enhanced images produced a modified geological map with well emphasized rock units which are verified with field observations, and petrographic study.

The Trifid Nebula: Stellar Sibling Rivalry

NASA Technical Reports Server (NTRS)

2001-01-01

A zoom into the Trifid Nebula starts with ground-based observations and ends with a Hubble Space Telescope (HST) image. Another HST image shows star formation in the nebula and the video concludes with a ground-based image of the Trifid Nebula.

A search for ejecta nebulae around Wolf-Rayet stars using the SHS Hα survey

NASA Astrophysics Data System (ADS)

Stock, D. J.; Barlow, M. J.

2010-12-01

Recent large-scale Galactic plane Hα surveys allow a re-examination of the environs of Wolf-Rayet (WR) stars for the presence of a circumstellar nebula. Using the morphologies of WR nebulae known to be composed of stellar ejecta as a guide, we constructed ejecta nebula criteria similar to those of Chu and searched for likely WR ejecta nebulae in the Southern Hα Survey (SHS). A new WR ejecta nebula around WR 8 is found and its morphology is discussed. The fraction of WR stars with ejecta-type nebulae is roughly consistent between the Milky Way (MW) and Large Magellanic Cloud (LMC) at around 5-6 per cent, with the MW sample dominated by nitrogen-rich WR central stars (WN type) and the LMC stars having a higher proportion of carbon-rich WR central stars (WC type). We compare our results with those of previous surveys, including those of Marston and Miller & Chu, and find broad consistency. We investigate several trends in the sample: most of the clear examples of ejecta nebulae have WNh central stars, and very few ejecta nebulae have binary central stars. Finally, the possibly unique evolutionary status of the nebula around the binary star WR 71 is explored.

THE TRIFID NEBULA: STELLAR SIBLING RIVALRY

NASA Technical Reports Server (NTRS)

2002-01-01

This NASA Hubble Space Telescope image of the Trifid Nebula reveals a stellar nursery being torn apart by radiation from a nearby, massive star. The picture also provides a peek at embryonic stars forming within an ill-fated cloud of dust and gas, which is destined to be eaten away by the glare from the massive neighbor. This stellar activity is a beautiful example of how the life cycles of stars like our Sun is intimately connected with their more powerful siblings. The Hubble image shows a small part of a dense cloud of dust and gas, a stellar nursery full of embryonic stars. This cloud is about 8 light-years away from the nebula's central star, which is beyond the top of this picture. Located about 9,000 light-years from Earth, the Trifid resides in the constellation Sagittarius. A stellar jet [the thin, wispy object pointing to the upper left] protrudes from the head of a dense cloud and extends three-quarters of a light-year into the nebula. The jet's source is a very young stellar object that lies buried within the cloud. Jets such as this are the exhaust gases of star formation. Radiation from the massive star at the center of the nebula is making the gas in the jet glow, just as it causes the rest of the nebula to glow. The jet in the Trifid is a 'ticker tape,' telling the history of one particular young stellar object that is continuing to grow as its gravity draws in gas from its surroundings. But this particular ticker tape will not run for much longer. Within the next 10,000 years the glare from the central, massive star will continue to erode the nebula, overrunning the forming star, and bringing its growth to an abrupt and possibly premature end. Another nearby star may have already faced this fate. The Hubble picture shows a 'stalk' [the finger-like object] pointing from the head of the dense cloud directly toward the star that powers the Trifid. This stalk is a prominent example of the evaporating gaseous globules, or 'EGGs,' that were seen previously in the Eagle Nebula, another star-forming region photographed by Hubble. The stalk has survived because at its tip there is a knot of gas that is dense enough to resist being eaten away by the powerful radiation. Reflected starlight at the tip of the EGG may be due to light from the Trifid's central star, or from a young stellar object buried within the EGG. Similarly, a tiny spike of emission pointing outward from the EGG looks like a small stellar jet. Hubble astronomers are tentatively interpreting this jet as the last gasp from a star that was cut off from its supply lines 100,000 years ago. The images were taken Sept. 8, 1997 through filters that isolate emission from hydrogen atoms, ionized sulfur atoms, and doubly ionized oxygen atoms. The images were combined in a single color composite picture. While the resulting picture is not true color, it is suggestive of what a human eye might see. Credits: NASA and Jeff Hester (Arizona State University)

Dynamo magnetic field-induced angular momentum transport in protostellar nebulae - The 'minimum mass' protosolar nebula

NASA Technical Reports Server (NTRS)

Stepinski, T. F.; Levy, E. H.

1990-01-01

Magnetic torques can produce angular momentum redistribution in protostellar nebulas. Dynamo magnetic fields can be generated in differentially rotating and turbulent nebulas and can be the source of magnetic torques that transfer angular momentum from a protostar to a disk, as well as redistribute angular momentum within a disk. A magnetic field strength of 100-1000 G is needed to transport the major part of a protostar's angular momentum into a surrounding disk in a time characteristic of star formation, thus allowing formation of a solar-system size protoplanetary nebula in the usual 'minimum-mass' model of the protosolar nebula. This paper examines the possibility that a dynamo magnetic field could have induced the needed angular momentum transport from the proto-Sun to the protoplanetary nebula.

Convection-enhanced delivery to the central nervous system.

PubMed

Lonser, Russell R; Sarntinoranont, Malisa; Morrison, Paul F; Oldfield, Edward H

2015-03-01

Convection-enhanced delivery (CED) is a bulk flow-driven process. Its properties permit direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while bypassing the blood-brain barrier. Development of surrogate imaging tracers that are co-infused during drug delivery now permit accurate, noninvasive real-time tracking of convective infusate flow in nervous system tissues. The potential advantages of CED in the CNS over other currently available drug delivery techniques, including systemic delivery, intrathecal and/or intraventricular distribution, and polymer implantation, have led to its application in research studies and clinical trials. The authors review the biophysical principles of convective flow and the technology, properties, and clinical applications of convective delivery in the CNS.

Family ties of WR to LBV nebulae yielding clues for stellar evolution

NASA Astrophysics Data System (ADS)

Weis, K.

Luminous Blue Variables (LBVs) are stars is a transitional phase massive stars may enter while evolving from main-sequence to Wolf-Rayet stars. The to LBVs intrinsic photometric variability is based on the modulation of the stellar spectrum. Within a few years the spectrum shifts from OB to AF type and back. During their cool phase LBVs are close to the Humphreys-Davidson (equivalent to Eddington/Omega-Gamma) limit. LBVs have a rather high mass loss rate, with stellar winds that are fast in the hot and slower in the cool phase of an LBV. These alternating wind velocities lead to the formation of LBV nebulae by wind-wind interactions. A nebula can also be formed in a spontaneous giant eruption in which larger amounts of mass are ejected. LBV nebulae are generally small (< 5 pc) mainly gaseous circumstellar nebulae, with a rather large fraction of LBV nebulae being bipolar. After the LBV phase the star will turn into a Wolf-Rayet star, but note that not all WR stars need to have passed the LBV phase. Some follow from the RSG and the most massive directly from the MS phase. In general WRs have a large mass loss and really fast stellar winds. The WR wind may interact with winds of earlier phases (MS, RSG) to form WR nebulae. As for WR with LBV progenitors the scenario might be different, here no older wind is present but an LBV nebula! The nature of WR nebulae are therefore manifold and in particular the connection (or family ties) of WR to LBV nebulae is important to understand the transition between these two phases, the evolution of massive stars, their winds, wind-wind and wind-nebula interactions. Looking at the similarities and differences of LBV and WR nebula, figuring what is a genuine LBV and WR nebula are the basic question addressed in the analysis presented here.

Primitive bodies - Molecular abundances in Comet Halley as probes of cometary formation environments

NASA Technical Reports Server (NTRS)

Lunine, Jonathan I.

1989-01-01

The most recent results on abundances of molecules in Halley's comet are examined in the context of various models for the environment in which comets formed. These environments include molecular clouds associated with star-forming regions, the solar nebula, gaseous disks around proto-planets, and combinations of these. Of all constituents in a cometary nucleus, the highly volatile molecules such as methane, ammonia, molecular nitrogen, and carbon monoxide are most sensitive to the final episode of cometary grain formation and incorporation in the comet's nucleus; hence they likely reflect at least some chemical processing in the solar nebula. Proper interpretation requires modeling of a number of physical processes including gas phase chemistry, chemistry on grain surfaces, and fractionation effects resulting from preferential incorporation of certain gases in proto-cometary grains. The abundance of methane in Halley's comet could be a key indicator of where that comet formed, provided the methane abundance on grains in star-forming regions can be observationally constrained.

Abundances of sulfur in the Milky Way Disk from Peimbert Type II planetary nebulae

NASA Astrophysics Data System (ADS)

Milingo, Jacquelynne Brenda

2000-08-01

Sulfur abundance gradients and heavy element ratios for the Milky Way Disk are constructed based upon newly acquired spectrophotometry of Type II planetary nebulae (PN). These spectra extend from 3600-9600 angstroms allowing us to use the [SIII] 9069 and 9532 angstrom lines to improve upon earlier sulfur abundance estimates. Considering a significant portion of sulfur in PN exists in the S(+2) ionization stage (and higher) this method should allow us to extrapolate more reliable total element abundance from ionic abundances. Given the progenitor mass and location of Type II PN (close to the Galactic disk), this sample of objects is free of nucleosynthetic self-contamination and thus their S abundances in particular are expected to reflect levels of these elements in the interstellar medium at the time of PN progenitor formation. These sulfur abundances provide constraints for studying various aspects of GCE such as massive star yields and the distribution of S across the Milky Way disk.

Hydrogenated Polycyclic Aromatic Hydrocarbons and the 2940 and 2850 Wavenumber (3.40 and 3.51 micron) Infrared Emission Features

NASA Technical Reports Server (NTRS)

Bernstein, Max P.; Sandford, Scott A.; Allamadola, Louis J.

1996-01-01

The 3150-2700/cm (3.17-3.70 micron) range of the spectra of a number of Ar-matrix-isolated PAHs containing excess H atoms (H(sub n)-PAHS) are presented. This region covers features produced by aromatic and aliphatic C-H stretching vibrations as well as overtone and combination bands involving lower lying fundamentals. The aliphatic C-H stretches in molecules of this type having low to modest excess H coverage provide excellent fits to a number of the weak emission features superposed on the plateau between 3080 and 2700/cm (3.25 and 3.7 micron) in the spectra of many planetary nebulae, reflection nebulae, and H II regions. Higher H coverage is implied for a few objects. We compare these results in context with the other suggested identifications of the emission features in the 2950-2700/cm (3.39-3.70 micron) region and briefly discuss their astrophysical implications.

The optical depth of the 158 micron forbidden C-12 II line - Detection of the F = 1 - 0 forbidden C-13 II hyperfine-structure component. [in Orion nebula

NASA Technical Reports Server (NTRS)

Stacey, G. J.; Townes, C. H.; Geis, N.; Madden, S. C.; Herrmann, F.; Genzel, R.; Poglitsch, A.; Jackson, J. M.

1991-01-01

The detection of the F = 1 - 0 hyperfine component of the 158-micron forbidden C-13 II fine-structure line in the interstellar medium is reported. A 12-point intensity map was obtained of the forbidden C-13 distribution over the inner 190-arcsec (R.A.) X 190-arcsec (decl.) regions of the Orion Nebula using an imaging Fabry-Perot interferometer. The forbidden C-12 II/C-13 II line intensity ratio varies significantly over the region mapped. It is highest (86 +/-0) in the core of the Orion H II region, and significantly lower (62 +/-7) in the outer regions of the map, reflecting higher optical depth in the forbidden C-12 II line here. It is suggested that this enhanced optical depth is the result of limb brightening of the optically thin forbidden C-13 II line at the edges of the bowl-shaped H II region blister.

MT Ser, a binary blue subdwarf

NASA Astrophysics Data System (ADS)

Shimanskii, V. V.; Borisov, N. V.; Sakhibullin, N. A.; Sheveleva, D. V.

2008-06-01

We have classified and determined the parameters of the evolved close binary MT Ser. Our moderate-resolution spectra covering various phases of the orbital period were taken with the 6-m telescope of the Special Astrophysical Observatory. The spectra of MT Ser freed from the contribution of the surrounding nebula Abell 41 contained no emission lines due to the reflection effect. The radial velocities measured from lines of different elements showed them to be constant on a time scale corresponding to the orbital period. At the same time, we find effects of broadening for the HeII absorption lines, due to the orbital motion of two hot stars of similar types. As a result, we classify MT Ser as a system with two blue subdwarfs after the common-envelope stage. We estimate the component masses and the distance to the object from the Doppler broadening of the HeII lines. We demonstrate that the age of the ambient nebula, Abell 41, is about 35 000 years.

A new survey of nebulae around Galactic Wolf-Rayet stars in the northern sky

NASA Technical Reports Server (NTRS)

Miller, Grant J.; Chu, You-Hua

1993-01-01

Interference filter CCD images have been obtained in H-alpha and forbidden O III 5007 A for 62 Wolf-Rayet (W-R) stars, representing a complete survey of nebulae around Galactic W-R stars in the northern sky. We find probable new ring nebulae around W-R stars number 113, 116 and 132, and possible new ring nebulae around W-R stars number 133 and 153. All survey images showing nebulosities around W-R stars are presented in this paper. New physical information is derived from the improved images of known ring nebulae. The absence of ring nebulae around most W-R stars is discussed.

Radio astronomy Explorer-1 observations of the Gum nebula

NASA Technical Reports Server (NTRS)

Alexander, J. K.

1971-01-01

Complicating factors in the spectrum analysis of the Gum nebula are discussed. These include accounting for the spectrum of supernova remnants in the direction of the nebula, the different absorption laws for radiation from beyond and within the nebula, and the Razin effect. This last results in a low frequency cutoff to the spectrum of synchrotron radiation by particles in a thermal plasma. These factors cause the observer to overestimate the amount of absorption occurring in the nebula. Data from the Explorer 38 satellite are presented for 3.93 and 6.55 MHz. Average optical depth for the nebula at 4 MHz was calculated.

The Formation of a Planetary Nebula.

ERIC Educational Resources Information Center

Harpaz, Amos

1991-01-01

Proposes a scenario to describe the formation of a planetary nebula, a cloud of gas surrounding a very hot compact star. Describes the nature of a planetary nebula, the number observed to date in the Milky Way Galaxy, and the results of research on a specific nebula. (MDH)

Trigonometric Parallaxes of Central Stars of Planetary Nebulae

DTIC Science & Technology

2007-02-01

is a large nebula with a larger outer halo (Hewett et al. 2003; Rauch et al. 2004). Frew& Parker (2006) find that the nebula may be ionized ISM. 3...TRIGONOMETRIC PARALLAXES OF CENTRAL STARS OF PLANETARY NEBULAE Hugh C. Harris,1 Conard C. Dahn, Blaise Canzian, Harry H. Guetter, S. K. Leggett,2...parallaxes of 16 nearby planetary nebulae are presented, including reduced errors for seven objects with previous initial results and results for six new

Ultraviolet observations of close-binary and pulsating nuclei of planetary nebulae; Winds and shells around low-mass supergiants; The close-binary nucleus of the planetary nebula HFG-1; A search for binary nuclei of planetary nebulae; UV monitoring of irregularly variable planetary nuclei; and The pulsating nucleus of the planetary nebula Lo 4

NASA Technical Reports Server (NTRS)

Bond, Howard E.

1992-01-01

A brief summary of the research highlights is presented. The topics covered include the following: binary nuclei of planetary nebulae; other variable planetary nuclei; low-mass supergiants; and other IUE-related research.

A community-based event delivery protocol in publish/subscribe systems for delay tolerant sensor networks.

PubMed

Liu, Nianbo; Liu, Ming; Zhu, Jinqi; Gong, Haigang

2009-01-01

The basic operation of a Delay Tolerant Sensor Network (DTSN) is to finish pervasive data gathering in networks with intermittent connectivity, while the publish/subscribe (Pub/Sub for short) paradigm is used to deliver events from a source to interested clients in an asynchronous way. Recently, extension of Pub/Sub systems in DTSNs has become a promising research topic. However, due to the unique frequent partitioning characteristic of DTSNs, extension of a Pub/Sub system in a DTSN is a considerably difficult and challenging problem, and there are no good solutions to this problem in published works. To ad apt Pub/Sub systems to DTSNs, we propose CED, a community-based event delivery protocol. In our design, event delivery is based on several unchanged communities, which are formed by sensor nodes in the network according to their connectivity. CED consists of two components: event delivery and queue management. In event delivery, events in a community are delivered to mobile subscribers once a subscriber comes into the community, for improving the data delivery ratio. The queue management employs both the event successful delivery time and the event survival time to decide whether an event should be delivered or dropped for minimizing the transmission overhead. The effectiveness of CED is demonstrated through comprehensive simulation studies.

Immunocontraceptive efficacy of synthetic peptides corresponding to major antigenic determinants of chicken riboflavin carrier protein in the female rats.

PubMed

Subramanian, S; Karande, A A; Adiga, P R

2000-09-01

Earlier studies have demonstrated that antibodies directed towards the N-terminal (residues 10-17) and C-terminal (residues 200-207) regions on chicken riboflavin carrier protein (RCP; 219 AA) are effective in pregnancy termination in rodents and sub-human primates. In the present study, the immunocontraceptive potential of three additional immunodominant sequences comprising of residues 33-49, 64 83 and 130-147 (CYA, CED and CGE peptides, respectively) of chicken RCP was investigated. The three antigenic peptides were synthesized by using Fmoc chemistry. Oligoclonal antibodies were generated in rabbits. Bioneutralizing capacity of these peptides was assessed by passive and active immunoneutralization studies. All the three peptides-specific antisera recognized their cognate epitopes on native RCP. When the affinity purified peptide IgG were administered on three consecutive days to pregnant rats (on days 10, 11 and 12), it was observed that the rats injected with CED and CGE-IgG failed to deliver any pups whereas the animals which received CYA IgG delivered normal pups. Active immunization of fertile female rats with CED or CGE peptide conferred protection from pregnancy. These results demonstrate the presence of two additional stretches in chicken RCP which can serve as mini-vaccines.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klumpp, John Allan; Bertelli, Luiz; Waters, Tom L.

For radionuclides such as plutonium and americium, detection of removable activity in the nose (i.e., nasal swab measurements) are frequently used to determine whether follow-up bioassay measurements are warranted following a potential intake. For this paper, the authors analyzed 429 nasal swab measurements taken following incidents or suspicious circumstances (such as an air monitor alarming) at Los Alamos National Laboratory (LANL) for which the dose was later evaluated using in vitro bioassay. Nasal swab measurements were found to be very poor predictors of dose and should not be used as such in the field. However, nasal swab measurements can bemore » indicative of whether a reliably detectable committed effective dose (CED) occurred. About 14% of nasal swab measurements between 1.25 and 16.7 Bq corresponded to CEDs greater than 1 mSv, so in general, positive nasal swabs always indicate that follow-up bioassay should be performed (positive nasal swabs less than 1.25 Bq are considered separately). This probability increased significantly for nasal swabs greater than 16.7 Bq. Only about 3% of nasal swabs with no detectable activity (NDA) corresponded to reliably detectable CEDs. As a result, a nasal swab with NDA is therefore necessary, but not sufficient, to negate the need for a follow-up bioassay if it was collected following other workplace indicators of a potential intake.« less

Cumulative effective radiation dose received by blunt trauma patients arriving to a military level I trauma center from point of injury and interhospital transfers.

PubMed

Van Arnem, Kerri A; Supinski, David P; Tucker, Jonathan E; Varney, Shawn

2016-12-01

Trauma patients sustaining blunt injuries are exposed to multiple radiologic studies. Evidence indicates that the risk of cancer from exposure to ionizing radiation rises in direct proportion to the cumulative effective dose (CED) received. The purpose of this study is to quantify the amount of ionizing radiation accumulated when arriving directly from point of injury to San Antonio Military Medical Center (SAMMC), a level I trauma center, compared with those transferred from other facilities. A retrospective record review was conducted from 1st January 2010 through 31st December 2012. The SAMMC trauma registry, electronic medical records, and the digital radiology imaging system were searched for possible candidates. The medical records were then analyzed for sex, age, mechanism of injury, received directly from point of injury (direct group), transfer from another medical facility (transfer group), computed tomographic scans received, dose-length product, CED of radiation, and injury severity score. A diagnostic imaging physicist then calculated the estimated CED each subject received based on the dose-length product of each computed tomographic scan. A total of 300 patients were analyzed, with 150 patients in the direct group and 150 patients in the transfer group. Both groups were similar in age and sex. Patients in the transfer group received a significantly greater CED of radiation compared with the direct group (mean, 37.6 mSv vs 28 mSv; P=.001). The radiation received in the direct group correlates with a lifetime attributable risk (LAR) of 1 in 357 compared with the transfer group with an increase in LAR to 1 in 266. Patients transferred to our facility received a 34% increase in ionizing radiation compared with patients brought directly from the injury scene. This increased dose of ionizing radiation contributes to the LAR of cancer and needs to be considered before repeating imaging studies. III. Published by Elsevier Inc.

Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial.

PubMed

Leffler, Daniel A; Kelly, Ciaran P; Green, Peter H R; Fedorak, Richard N; DiMarino, Anthony; Perrow, Wendy; Rasmussen, Henrik; Wang, Chao; Bercik, Premysl; Bachir, Natalie M; Murray, Joseph A

2015-06-01

Celiac disease (CeD) is a prevalent autoimmune condition. Recurrent signs and symptoms are common despite treatment with a gluten-free diet (GFD), yet no approved or proven nondietary treatment is available. In this multicenter, randomized, double-blind, placebo-controlled study, we assessed larazotide acetate 0.5, 1, or 2 mg 3 times daily to relieve ongoing symptoms in 342 adults with CeD who had been on a GFD for 12 months or longer and maintained their current GFD during the study. The study included a 4-week placebo run-in, 12 weeks of treatment, and a 4-week placebo run-out phase. The primary end point was the difference in average on-treatment Celiac Disease Gastrointestinal Symptom Rating Scale score. The primary end point was met with the 0.5-mg dose of larazotide acetate, with fewer symptoms compared with placebo by modified intention to treat (n = 340) (analysis of covariance, P = .022; mixed model for repeated measures, P = .005). The 0.5-mg dose showed an effect on exploratory end points including a 26% decrease in celiac disease patient-reported outcome symptomatic days (P = .017), a 31% increase in improved symptom days (P = .034), a 50% or more reduction from baseline of the weekly average abdominal pain score for 6 or more of 12 weeks of treatment (P = .022), and a decrease in the nongastrointestinal symptoms of headache and tiredness (P = .010). The 1- and 2-mg doses were no different than placebo for any end point. Safety was comparable with placebo. Larazotide acetate 0.5 mg reduced signs and symptoms in CeD patients on a GFD better than a GFD alone. Although results were mixed, this study was a successful trial of a novel therapeutic agent targeting tight junction regulation in patients with CeD who are symptomatic despite a GFD. Clinicaltrials.gov: NCT01396213. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

Determination of Chromium(III), Chromium(VI), and Chromium(III) acetylacetonate in water by ion-exchange disk extraction/metal furnace atomic absorption spectrometry

NASA Astrophysics Data System (ADS)

Kamakura, Nao; Inui, Tetsuo; Kitano, Masaru; Nakamura, Toshihiro

A new method for the separate determination of Chromium(III) (Cr(III)), Chromium(VI) (Cr(VI)), and Cr(III) acetylacetonate (Cr(acac)3) in water was developed using a cation-exchange extraction disk (CED) and an anion-exchange extraction disk (AED) combined with metal furnace atomic absorption spectrometry (MFAAS). A 100-mL water sample was adjusted to pH 5.6 and passed through the CED placed on the AED. Cr(acac)3 and Cr(III) were adsorbed on the CED, and Cr(VI) was adsorbed on the AED. The adsorbed Cr(acac)3 was eluted with 50 mL of carbon tetrachloride, followed by the elution of Cr(III) with 50 mL of 3 mol L- 1 nitric acid. Cr(VI) was eluted with 50 mL of 3 mol L- 1 nitric acid. The chemical species of Cr eluted from the CED with carbon tetrachloride was identified as Cr(acac)3 using infrared spectroscopy. The eluate of Cr(acac)3 was diluted to 100 mL with carbon tetrachloride, and those of Cr(III) and Cr(VI) were diluted to 100 mL with deionized water. All of the solutions were subsequently analyzed by MFAAS. The calibration curve for the Cr(acac)3 aqueous solutions exhibited good linearity in the range of 0.1 to 1 ng. The detection limit of Cr, which corresponded to three times the standard deviation (n = 10) of the blank values, was 20 pg. The recovery test for Cr(III), Cr(VI), and Cr(acac)3 exhibited desirable results (96.0%-107%) when 5 μg of each species (50 μg L- 1) was added to 100 mL water samples (i.e., tap water, rainwater, and bottled drinking water). In a humic acid solution, Cr(acac)3 was quantitatively recovered (103%), but Cr(III) and Cr(VI) exhibited poor recoveries (i.e., 84.8% and 78.4%, respectively).

Minimally invasive convection-enhanced delivery of biologics into dorsal root ganglia: validation in the pig model and prospective modeling in humans. Technical note.

PubMed

Pleticha, Josef; Maus, Timothy P; Christner, Jodie A; Marsh, Michael P; Lee, Kendall H; Hooten, W Michael; Beutler, Andreas S

2014-10-01

Dorsal root ganglia (DRG) are critical anatomical structures involved in nociception. Intraganglionic (IG) drug delivery is therefore an important route of administration for novel analgesic therapies. Although IG injection in large animal models is highly desirable for preclinical biodistribution and toxicology studies of new drugs, no method to deliver pharmaceutical agents into the DRG has been reported in any large species. The present study describes a minimally invasive technique of IG agent delivery in domestic swine, one of the most common large animal models. The technique utilizes CT guidance for DRG targeting and a custom-made injection assembly for convection enhanced delivery (CED) of therapeutic agents directly into DRG parenchyma. The DRG were initially visualized by CT myelography to determine the optimal access route to the DRG. The subsequent IG injection consisted of 3 steps. First, a commercially available guide needle was advanced to a position dorsolateral to the DRG, and the dural root sleeve was punctured, leaving the guide needle contiguous with, but not penetrating, the DRG. Second, the custom-made stepped stylet was inserted through the guide needle into the DRG parenchyma. Third, the stepped stylet was replaced by the custom-made stepped needle, which was used for the IG CED. Initial dye injections performed in pig cadavers confirmed the accuracy of DRG targeting under CT guidance. Intraganglionic administration of adeno-associated virus in vivo resulted in a unilateral transduction of the injected DRG, with 33.5% DRG neurons transduced. Transgene expression was also found in the dorsal root entry zones at the corresponding spinal levels. The results thereby confirm the efficacy of CED by the stepped needle and a selectivity of DRG targeting. Imaging-based modeling of the procedure in humans suggests that IG CED may be translatable to the clinical setting.

Convection-enhanced drug delivery of interleukin-4 Pseudomonas exotoxin (PRX321): increased distribution and magnetic resonance monitoring.

PubMed

Mardor, Y; Last, D; Daniels, D; Shneor, R; Maier, S E; Nass, D; Ram, Z

2009-08-01

Convection-enhanced drug delivery (CED) enables achieving a drug concentration within brain tissue and brain tumors that is orders of magnitude higher than by systemic administration. Previous phase I/II clinical trials using intratumoral convection of interleukin-4 Pseudomonas exotoxin (PRX321) have demonstrated an acceptable safety and toxicity profile with promising signs of therapeutic activity. The present study was designed to assess the distribution efficiency and toxicity of this PRX321 using magnetic resonance imaging (MRI) and to test whether reformulation with increased viscosity could enhance drug distribution. Convection of low- [0.02% human serum albumin (HSA)] and high-viscosity (3% HSA) infusates mixed with gadolinium-diethylenetriamine pentaacetic acid and PRX321 were compared with low- and high-viscosity infusates without the drug, in normal rat brains. MRI was used for assessment of drug distribution and detection of early and late toxicity. Representative brain samples were subjected to histological examination. Distribution volumes calculated from the magnetic resonance images showed that the average distribution of 0.02% HSA was larger than that of 0.02% HSA with PRX321 by a factor of 1.98 (p < 0.02). CED of 3.0% HSA, with or without PRX321, tripled the volume of distribution compared with 0.02% HSA with PRX321 (p < 0.015). No drug-related toxicity was detected. These results suggest that the impeded convection of the PRX321 infusate used in previous clinical trials can be reversed by increasing infusate viscosity and lead to tripling of the volume of distribution. This effect was not associated with any detectable toxicity. A similar capability to reverse impeded convection was also demonstrated in a CED model using acetic acid. These results will be implemented in an upcoming phase IIb PRX321 CED trial with a high-viscosity infusate.

Earthquake Energy Dissipation in Light of High-Velocity, Slip-Pulse Shear Experiments

NASA Astrophysics Data System (ADS)

Reches, Z.; Liao, Z.; Chang, J. C.

2014-12-01

We investigated the energy dissipation during earthquakes by analysis of high-velocity shear experiments conducted on room-dry, solid samples of granite, tonalite, and dolomite sheared at slip-velocity of 0.0006-1m/s, and normal stress of 1-11.5MPa. The experimental fault were loaded in one of three modes: (1) Slip-pulse of abrupt, intense acceleration followed by moderate deceleration; (2) Impact by a spinning, heavy flywheel (225 kg); and (3) Constant velocity loading. We refer to energy dissipation in terms of power-density (PD=shear stress*slip-velocity; units of MW/m^2), and Coulomb-energy-density (CED= mechanical energy/normal stress; units of m). We present two aspects: Relative energy dissipation of the above loading modes, and relative energy dissipation between impact experiments and moderate earthquakes. For the first aspect, we used: (i) the lowest friction coefficient of the dynamic weakening; (ii) the work dissipated before reaching the lowest friction; and (iii) the cumulative mechanical work during the complete run. The results show that the slip-pulse/impact modes are energy efficient relatively to the constant-velocity mode as manifested by faster, more intense weakening and 50-90% lower energy dissipation. Thus, for a finite amount of pre-seismic crustal energy, the efficiency of slip-pulse would amplify earthquake instability. For the second aspect, we compare the experimental CED of the impact experiments to the reported breakdown energy (EG) of moderate earthquakes, Mw = 5.6 to 7.2 (Chang et al., 2012). In is commonly assumed that the seismic EG is a small fraction of the total earthquake energy, and as expected in 9 out of 11 examined earthquakes, EG was 0.005 to 0.07 of the experimental CED. We thus speculate that the experimental relation of Coulomb-energy-density to total slip distance, D, CED = 0.605 × D^0.933, is a reasonable estimate of total earthquake energy, a quantity that cannot be determined from seismic data.

Camurati-Engelmann disease: unique variant featuring a novel mutation in TGFβ1 encoding transforming growth factor beta 1 and a missense change in TNFSF11 encoding RANK ligand.

PubMed

Whyte, Michael P; Totty, William G; Novack, Deborah V; Zhang, Xiafang; Wenkert, Deborah; Mumm, Steven

2011-05-01

We report a 32-year-old man and his 59-year-old mother with a unique and extensive variant of Camurati-Engelmann disease (CED) featuring histopathological changes of osteomalacia and alterations within TGFβ1 and TNFSF11 encoding TGFβ1 and RANKL, respectively. He suffered leg pain and weakness since childhood and reportedly grew until his late 20s, reaching 7 feet in height. He had deafness, perforated nasal septum, torus palatinus, disproportionately long limbs with knock-knees, low muscle mass, and pseudoclubbing. Radiographs revealed generalized skeletal abnormalities, including wide bones and cortical and trabecular bone thickening in keeping with CED, except that long bone ends were also affected. Lumbar spine and hip BMD Z-scores were + 7.7 and + 4.4, respectively. Biochemical markers of bone turnover were elevated. Hypocalciuria accompanied low serum 25-hydroxyvitamin D (25[OH]D) levels. Pituitary hypogonadism and low serum insulin-like growth factor (IGF)-1 were present. Karyotype was normal. Despite vitamin D repletion, iliac crest histology revealed severe osteomalacia. Exon 1 of TNFRSF11A (RANK), exons 2, 3, and 4 of LRP5, and all coding exons and adjacent mRNA splice junctions of TNFRSF11B (OPG), SQSTM1 (sequestosome 1), and TNSALP (tissue nonspecific alkaline phosphatase) were intact. His asymptomatic and less dysmorphic 5'11″ mother, also with low serum 25(OH)D, had milder clinical, radiological, biochemical, and histopathological findings. Both individuals were heterozygous for a novel 12-bp duplication (c.27_38dup, p.L10_L13dup) in exon 1 of TGFβ1, predicting four additional leucine residues in the latency-associated-peptide segment of TGFβ1, consistent with CED. The son was also homozygous for a single base transversion in TNFSF11, predicting a nonconservative amino acid change (c.107C > G, p.Pro36Arg) in the intracellular domain of RANKL that was heterozygous in his nonconsanguineous parents. This TNFSF11 variant was not found in the SNP Database, nor in published TNFSF11 association studies, but it occurred in four of the 134 TNFSF11 alleles (3.0%) we tested randomly among individuals without CED. Perhaps the unique phenotype of this CED family is conditioned by altered RANKL activity. Copyright © 2011 American Society for Bone and Mineral Research.

Ramped-rate vs continuous-rate infusions: An in vitro comparison of convection enhanced delivery protocols.

PubMed

Schomberg, Dominic; Wang, Anyi; Marshall, Hope; Miranpuri, Gurwattan; Sillay, Karl

2013-04-01

Convection enhanced delivery (CED) is a technique using infusion convection currents to deliver therapeutic agents into targeted regions of the brain. Recently, CED is gaining significant acceptance for use in gene therapy of Parkinson's disease (PD) employing direct infusion into the brain. CED offers advantages in that it targets local areas of the brain, bypasses the blood-brain barrier (BBB), minimizes systemic toxicity of the therapeutics, and allows for delivery of larger molecules that diffusion driven methods cannot achieve. Investigating infusion characteristics such as backflow and morphology is important in developing standard and effective protocols in order to successfully deliver treatments into the brain. Optimizing clinical infusion protocols may reduce backflow, improve final infusion cloud morphology, and maximize infusate penetrance into targeted tissue. The purpose of the current study was to compare metrics during ramped-rate and continuous-rate infusions using two different catheters in order to optimize current infusion protocols. Occasionally, the infusate refluxes proximally up the catheter tip, known as backflow, and minimizing this can potentially reduce undesirable effects in the clinical setting. Traditionally, infusions are performed at a constant rate throughout the entire duration, and backflow is minimized only by slow infusion rates, which increases the time required to deliver the desired amount of infusate. In this study, we investigate the effects of ramping and various infusion rates on backflow and infusion cloud morphology. The independent parameters in the study are: ramping, maximum infusion rate, time between rate changes, and increments of rate changes. Backflow was measured using two methods: i) at the point of pressure stabilization within the catheter, and ii) maximum backflow as shown by video data. Infusion cloud morphology was evaluated based on the height-to-width ratio of each infusion cloud at the end of each experiment. Results were tabulated and statistically analyzed to identify any significant differences between protocols. The experimental results show that CED rampedrate infusion protocols result in smaller backflow distances and more spherical cloud morphologies compared to continuous-rate infusion protocols ending at the same maximum infusion rate. Our results also suggest internal-line pressure measurements can approximate the time-point at which backflow ceases. Our findings indicate that ramping CED infusion protocols can potentially minimize backflow and produce more spherical infusion clouds. However, further research is required to determine the strength of this correlation, especially in relation to maximum infusion rates.

VizieR Online Data Catalog: MIPS 24um nebulae (Gvaramadze+, 2010)

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Kniazev, A. Y.; Fabrika, S.

2011-03-01

Massive evolved stars lose a large fraction of their mass via copious stellar wind or instant outbursts. During certain evolutionary phases, they can be identified by the presence of their circumstellar nebulae. In this paper, we present the results of a search for compact nebulae (reminiscent of circumstellar nebulae around evolved massive stars) using archival 24um data obtained with the Multiband Imaging Photometer for Spitzer. We have discovered 115 nebulae, most of which bear a striking resemblance to the circumstellar nebulae associated with luminous blue variables (LBVs) and late WN-type (WNL) Wolf-Rayet (WR) stars in the Milky Way and the Large Magellanic Cloud (LMC). (1 data file).

The effects of mass and metallicity upon planetary nebula formation

NASA Astrophysics Data System (ADS)

Papp, K. A.; Purton, C. R.; Kwok, S.

1983-05-01

A parameterized function is constructed which describes the possible dependence of planetary nebula formation upon metal abundance and stellar mass. Data on galaxies in the Local Group compared with predictions made from the parameterized function indicate that heavy element abundance is the principal agent influencing the formation of planetary nebulae; stars which are rich in heavy elements are the progenitors of planetary nebulae. This analysis, when compared with the observations, argues for a modest degree of pre-enrichment in a few of the sample galaxies. The heavy element dependence of planetary nebula formation also accounts for the deficit of planetary nebulae in the nuclei of NGC 221 and NGC 224, and in the bulge of our Galaxy.

Bi-Abundance Ionisation Structure of the Wolf-Rayet Planetary Nebula PB 8

NASA Astrophysics Data System (ADS)

Danehkar, A.

2018-01-01

The planetary nebula PB 8 around a [WN/WC]-hybrid central star is one of planetary nebulae with moderate abundance discrepancy factors (ADFs 2-3), which could be an indication of a tiny fraction of metal-rich inclusions embedded in the nebula (bi-abundance). In this work, we have constructed photoionisation models to reproduce the optical and infrared observations of the planetary nebula PB 8 using a non-LTE stellar model atmosphere ionising source. A chemically homogeneous model initially used cannot predict the optical recombination lines. However, a bi-abundance model provides a better fit to most of the observed optical recombination lines from N and O ions. The metal-rich inclusions in the bi-abundance model occupy 5.6% of the total volume of the nebula, and are roughly 1.7 times cooler and denser than the mean values of the surrounding nebula. The N/H and O/H abundance ratios in the metal-rich inclusions are 1.0 and 1.7 dex larger than the diffuse warm nebula, respectively. To reproduce the Spitzer spectral energy distribution of PB 8, dust grains with a dust-to-gas ratio of 0.01 (by mass) were also included. It is found that the presence of metal-rich inclusions can explain the heavy element optical recombination lines, while a dual-dust chemistry with different grain species and discrete grain sizes likely produces the infrared continuum of this planetary nebula. This study demonstrates that the bi-abundance hypothesis, which was examined in a few planetary nebulae with large abundance discrepancies (ADFs > 10), could also be applied to those typical planetary nebulae with moderate abundance discrepancies.

On planetary nebulae as sources of carbon dust: Infrared emission from planetary nebulae of the galactic halo

NASA Technical Reports Server (NTRS)

Dinerstein, Harriet L.; Lester, Daniel F.

1990-01-01

Planetary nebulae of the galactic disk are generally seen to emit a thermal continuum due to dust grains heated by stellar and nebular photons. This continuum typically peaks between 25 and 60 micron m, so that the total power emitted by the dust is sampled well by the broad-band measurements made by IRAS. Researchers examine here the characteristics of the infrared emission from the four planetary nebulae which are believed on the basis of their low overall metallicities to belong to the halo population. These nebulae are of particular interest because they are the most metal-poor ionized nebulae known in our Galaxy, and offer the opportunity to probe possible dependences of the dust properties on nebular composition. Researchers present fluxes extracted from co-addition of the IRAS data, as well as ground-based near infrared measurements. Each of the four halo objects, including the planetary nebula in the globular cluster M15, is detected in at least one infrared band. Researchers compare the estimated infrared excesses of these nebulae (IRE, the ratio of measured infrared power to the power available in the form of resonantly-trapped Lyman alpha photons) to those of disk planetary nebulae with similar densities but more normal abundances. Three of the halo planetaries have IRE values similar to those of the disk nebulae, despite the fact that their Fe- and Si-peak gas phase abundances are factors of 10 to 100 lower. However, these halo nebulae have normal or elevated C/H ratios, due to nuclear processing and mixing in their red giant progenitors. Unlike the other halo planetaries, DDDM1 is deficient in carbon as well as in the other light metals. This nebula has a substantially lower IRE than the other halo planetaries, and may be truly dust efficient. Researchers suggest that the deficiency is due to a lack of the raw material for producing carbon-based grains, and that the main bulk constituent of the dust in these planetary nebulae is carbon.

Pieces of the Puzzle: Tracking the Chemical Component of the ...

EPA Pesticide Factsheets

This presentation provides an overview of the risk assessment conducted at the U.S. EPA, as well as some research examples related to the exposome concept. This presentation also provides the recommendation of using two organizational and predictive frameworks for tracking chemical components in the exposome. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

Therapeutic Ultrasound Enhancement of Drug Delivery to Soft Tissues

NASA Astrophysics Data System (ADS)

Lewis, George; Wang, Peng; Lewis, George; Olbricht, William

2009-04-01

Effects of exposure to 1.58 MHz focused ultrasound on transport of Evans Blue Dye (EBD) in soft tissues are investigated when an external pressure gradient is applied to induce convective flow through the tissue. The magnitude of the external pressure gradient is chosen to simulate conditions in brain parenchyma during convection-enhanced drug delivery (CED) to the brain. EBD uptake and transport are measured in equine brain, avian muscle and agarose brain-mimicking phantoms. Results show that ultrasound enhances EBD uptake and transport, and the greatest enhancement occurs when the external pressure gradient is applied. The results suggest that exposure of the brain parenchyma to ultrasound could enhance penetration of material infused into the brain during CED therapy.

The Air Quality Model Evaluation International Initiative ...

EPA Pesticide Factsheets

This presentation provides an overview of the Air Quality Model Evaluation International Initiative (AQMEII). It contains a synopsis of the three phases of AQMEII, including objectives, logistics, and timelines. It also provides a number of examples of analyses conducted through AQMEII with a particular focus on past and future analyses of deposition. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

A study of the far infrared counterparts of new candidates for planetary nebulae

NASA Astrophysics Data System (ADS)

Iyengar, K. V. K.

1986-05-01

The IRAS Point Source Catalog was searched for infrared counterparts of the fourteen new candidates for planetary nebulae of low surface brightness detected by Hartl and Tritton (1985). Five of these candidates were identified with sources in the Catalog. All five nebulae are found in regions of high cirrus flux at 100 microns, and all have both point sources and small size extended sources with numbers varying from field to field. The infrared emission from these nebulae is connected with dust temperatures of about 100 K, characteristic of planetary nebulae.

Spacelab

NASA Image and Video Library

1990-03-20

This photograph was taken during the integration of the Astro-1 mission payloads at the Kennedy Space Center on March 20, 1990, showing the Broad Band X-Ray Telescope (BBXRT) at the left, as three telescopes for the Astro-1 Observatory are settled into the Orbiter Columbia payload bay. Above Earth's atmospheric interference, Astro-1 would make precise measurements of objects such as planets, stars, and galaxies in relatively small fields of view and would observe and measure ultraviolet radiation from celestial objects. The Astro-1 used a Spacelab pallet system with an instrument pointing system and a cruciform structure for bearing the three ultraviolet instruments mounted in a parallel configuration. The three instruments were: The Hopkins Ultraviolet Telescope (HUT), which was designed to obtain far-ultraviolet spectroscopic data from white dwarfs, emission nebulae, active galaxies, and quasars; the Wisconsin Ultraviolet Photo-Polarimeter Experiment (WUPPE) which was to study polarized ultraviolet light from magnetic white dwarfs, binary stars, reflection nebulae, and active galaxies; and the Ultraviolet Imaging Telescope (UIT), which was to record photographic images in ultraviolet light of galaxies, star clusters, and nebulae. The star trackers that supported the instrument pointing system, were also mounted on the cruciform. Also in the payload bay was the Broad Band X-Ray Telescope (BBXRT), which was designed to obtain high-resolution x-ray spectra from stellar corona, x-ray binary stars, active galactic nuclei, and galaxy clusters. Managed by the Marshall Space Flight Center, the Astro-1 observatory was launched aboard the Space Shuttle Orbiter Columbia (STS-35) on December 2, 1990.

Submillimeter astronomy at the NASA/University of Hawaii 3-meter infrared telescope facility

NASA Technical Reports Server (NTRS)

1983-01-01

Problems encountered in the design of a submillimeter photometer for the infrared telescope facility and some of the solutions already provided are described. Observations of Saturn's rings and the determination of the brightness temperature of Titan, Jupiter, Saturn, Neptune, and Uranus are summarized. Significant findings during solar, galactic, and extragalactic observations include the discovery of low luminosity star formation in the Bok Globule B335 and determination of the far infrared properties of dust in the reflection nebula NGC 7023.

An IFU-view of Planetary Nebulae: Exploring NGC 6720 (Ring Nebula) with KCWI

NASA Astrophysics Data System (ADS)

Hoadley, Keri; Matuszewski, Matt; Hamden, Erika; Martin, Christopher; Neill, Don; Kyne, Gillian

2018-01-01

Studying the interaction between the ejected stellar material and interstellar clouds is important for understanding how stellar deaths influences the pollution of matter that will later form other stars. Planetary nebulae provide ideal laboratories to study such interactions. I will present on a case study of one close-by planetary nebula, the Ring Nebula (M 57, NGC 6720), to infer the abundances, temperatures, structures, and dynamics of important atomic and ionic species in two distinct regions of the nebula using a newly-commissioned integral field spectrograph (IFS) on Keck: the Keck Cosmic Web Imager (KCWI). The advantage of an IFS over traditional filter-imaging techniques is the ability to simultaneously observe the spectrum of any given pixel in the imaging area, which provides crucial information about the dynamics of the observed region. This technique is powerful for diffuse or extended astrophysical objects, and I will demonstrate the different imaging and spectral modes of KCWI used to observe the Ring Nebula.KCWI observations of the Ring Nebula focused mainly on the innermost region of the nebula, with a little coverage of the Inner Ring. We also observed the length of the Ring in one set of observations, for which we will estimate the elemental abundances, temperatures, and dynamics of the region. KCWI observations also capture an inner arc and blob that have distinctly difference characteristics than the Ring itself and may be a direct observation of either the planetary nebula ramming into an interstellar cloud projected onto the sightline or a dense interstellar cloud being illuminated by the stellar continuum from the hot central white dwarf.

Nebula--a web-server for advanced ChIP-seq data analysis.

PubMed

Boeva, Valentina; Lermine, Alban; Barette, Camille; Guillouf, Christel; Barillot, Emmanuel

2012-10-01

ChIP-seq consists of chromatin immunoprecipitation and deep sequencing of the extracted DNA fragments. It is the technique of choice for accurate characterization of the binding sites of transcription factors and other DNA-associated proteins. We present a web service, Nebula, which allows inexperienced users to perform a complete bioinformatics analysis of ChIP-seq data. Nebula was designed for both bioinformaticians and biologists. It is based on the Galaxy open source framework. Galaxy already includes a large number of functionalities for mapping reads and peak calling. We added the following to Galaxy: (i) peak calling with FindPeaks and a module for immunoprecipitation quality control, (ii) de novo motif discovery with ChIPMunk, (iii) calculation of the density and the cumulative distribution of peak locations relative to gene transcription start sites, (iv) annotation of peaks with genomic features and (v) annotation of genes with peak information. Nebula generates the graphs and the enrichment statistics at each step of the process. During Steps 3-5, Nebula optionally repeats the analysis on a control dataset and compares these results with those from the main dataset. Nebula can also incorporate gene expression (or gene modulation) data during these steps. In summary, Nebula is an innovative web service that provides an advanced ChIP-seq analysis pipeline providing ready-to-publish results. Nebula is available at http://nebula.curie.fr/ Supplementary data are available at Bioinformatics online.

Protoplanetary Nebulae

NASA Astrophysics Data System (ADS)

Kwok, S.; Murdin, P.

2000-11-01

Protoplanetary nebulae (or pre-planetary nebulae, PPNs) are defined as objects that are in transition between the asymptotic giant branch (AGB) and planetary nebula phases of STELLAR EVOLUTION. Stars on the AGB lose mass at a high rate ((10-7-10-4)M⊙ yr-1) in the form of a stellar wind. Such mass loss eventually depletes the hydrogen envelope of the star and exposes the electron-degenerate carbon...

Where Do Messy Planetary Nebulae Come From?

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-03-01

If you examined images of planetary nebulae, you would find that many of them have an appearance that is too messy to be accounted for in the standard model of how planetary nebulae form. So what causes these structures?Examples of planetary nebulae that have a low probability of having beenshaped by a triple stellar system. They are mostly symmetric, with only slight departures (labeled) that can be explained by instabilities, interactions with the interstellar medium, etc. [Bear and Soker 2017]A Range of LooksAt the end of a stars lifetime, in the red-giant phase, strong stellar winds can expel the outer layers of the star. The hot, luminous core then radiates in ultraviolet, ionizing the gas of the ejected stellar layers and causing them to shine as a brightly colored planetary nebula for a few tens of thousands of years.Planetary nebulae come in a wide variety of morphologies. Some are approximately spherical, but others can be elliptical, bipolar, quadrupolar, or even more complex.Its been suggested that non-spherical planetary nebulae might be shaped by the presence of a second star in a binary system with the source of the nebula but even this scenario should still produce a structure with axial or mirror symmetry.A pair of scientists from Technion Israel Institute of Technology, Ealeal Bear and Noam Soker, argue that planetary nebulae with especially messy morphologies those without clear axial or point symmetries may have been shaped by an interacting triple stellar system instead.Examples of planetary nebulae that might have been shaped by a triple stellar system. They have some deviations from symmetry but also show signs of interacting with the interstellar medium. [Bear and Soker 2017]Departures from SymmetryTo examine this possibility more closely, Bear and Soker look at a sample of thousands planetary nebulae and qualitatively classify each of them into one of four categories, based on the degree to which they show signs of having been shaped by a triple stellar progenitor. The primary signs the authors look for are:SymmetriesIf a planetary nebula has a strong axisymmetric or point-symmetric structure (i.e., its bipolar, elliptical, spherical, etc.), it was likely not shaped by a triple progenitor. If clear symmetries are missing, however, or if there is a departure from symmetry in specific regions, the morphology of the planetary nebula may have been shaped by the presence of stars in a close triple system.Interaction with the interstellar mediumSome asymmetries, especially local ones, can be explained by interaction of the planetary nebula with the interstellar medium. The authors look for signs of such an interaction, which decreases the likelihood that a triple stellar system need be involved to produce the morphology we observe.Examples of planetary nebulae that are extremely likely to have been shaped by a triple stellar system. They have strong departures from symmetry and dont show signs of interacting with the interstellar medium. [Bear and Soker 2017]Influential TriosFrom the images in two planetary nebulae catalogs the Planetary Nebula Image Catelog and the HASH catalog Bear and Soker find that 275 and 372 planetary nebulae are categorizable, respectively. By assigning crude probabilities to their categories, the authors estimate that the total fraction of planetary nebulae shaped by three stars in a close system is around 1321%.The authors argue that in some cases, all three stars might survive. This means that we may be able to find direct evidence of these triple stellar systems lying in the hearts of especially messy planetary nebulae.CitationEaleal Bear and Noam Soker 2017 ApJL 837 L10. doi:10.3847/2041-8213/aa611c

Use Case Analysis for Adopting Cloud Computing in Army Test and Evaluation

DTIC Science & Technology

2010-09-01

FedRAMP) .............................................................................27 c. National Aeronautics and Space Administration (NASA) Nebula ...25 Figure 11. NASA Nebula Container from...NASA Flagship Initiatives: Nebula ,” 2010

Lightning in the Protoplanetary Nebula?

NASA Technical Reports Server (NTRS)

Love, Stanley G.

1997-01-01

Lightning in the protoplanetary nebula has been proposed as a mechanism for creating meteoritic chondrules: enigmatic mm-sized silicate spheres formed in the nebula by the brief melting of cold precursors.

Nature versus Nurture: Luminous Blue Variable Nebulae in and near Massive Stellar Clusters at the Galactic Center

NASA Astrophysics Data System (ADS)

Lau, R. M.; Herter, T. L.; Morris, M. R.; Adams, J. D.

2014-04-01

Three luminous blue variables (LBVs) are located in and near the Quintuplet Cluster at the Galactic center: the Pistol Star, G0.120-0.048, and qF362. We present imaging at 19, 25, 31, and 37 μm of the region containing these three LBVs, obtained with SOFIA using FORCAST. We argue that Pistol and G0.120-0.048 are identical "twins" that exhibit contrasting nebulae due to the external influence of their different environments. Our images reveal the asymmetric, compressed shell of hot dust surrounding the Pistol Star and provide the first detection of the thermal emission from the symmetric, hot dust envelope surrounding G0.120-0.048. However, no detection of hot dust associated with qF362 is made. Dust and gas composing the Pistol nebula are primarily heated and ionized by the nearby Quintuplet Cluster stars. The northern region of the Pistol nebula is decelerated due to the interaction with the high-velocity (2000 km s-1) winds from adjacent Wolf-Rayet Carbon (WC) stars. From fits to the spectral energy distribution (SED) of the Pistol nebula with the DustEM code we determine that the Pistol nebula is composed of a distribution of very small, transiently heated grains (10 to ~ 35 Å) having a total dust mass of 0.03 M ⊙, and that it exhibits a gradient of decreasing grain size from south to north due to differential sputtering by the winds from the WC stars. The total IR luminosity of the Pistol nebula is 5.2 × 105 L ⊙. Dust in the G0.120-0.048 nebula is primarily heated by the central star; however, the nebular gas is ionized externally by the Arches Cluster. Unlike the Pistol nebula, the G0.120-0.048 nebula is freely expanding into the surrounding medium. A grain size distribution identical to that of the non-sputtered region of the Pistol nebula satisfies the constraints placed on the G0.120-0.048 nebula from DustEM model fits to its SED and implies a total dust mass of 0.021 M ⊙. The total IR luminosity of the G0.120-0.048 nebula is ~105 L ⊙. From Paschen-α and 6 cm observations we determine a total gas mass of 9.3 M ⊙ and 6.2 M ⊙ for the Pistol and G0.120-0.048 nebulae, respectively. Given the independent dust and gas mass estimates we find that the Pistol and G0.120-0.048 nebulae exhibit similar gas-to-dust mass ratios of 310^{+77}_{-52} and 293^{+73}_{-101}, respectively. Both nebulae share identical size scales (~0.7 pc) which suggests that they have similar dynamical timescales of ~104 yr, assuming a shell expansion velocity of v exp = 60 km s-1.

The Twin Jet Nebula

NASA Image and Video Library

2015-08-26

The Twin Jet Nebula, or PN M2-9, is a striking example of a bipolar planetary nebula. Bipolar planetary nebulae are formed when the central object is not a single star, but a binary system, Studies have shown that the nebula’s size increases with time, and measurements of this rate of increase suggest that the stellar outburst that formed the lobes occurred just 1200 years ago.

Evolutionary status of the Of?p star HD 148937 and of its surrounding nebula NGC 6164/5

NASA Astrophysics Data System (ADS)

Mahy, L.; Hutsemékers, D.; Nazé, Y.; Royer, P.; Lebouteiller, V.; Waelkens, C.

2017-03-01

Aims: The magnetic star HD 148937 is the only Galactic Of?p star surrounded by a nebula. The structure of this nebula is particularly complex and is composed, from the center out outwards, of a close bipolar ejecta nebula (NGC 6164/5), an ellipsoidal wind-blown shell, and a spherically symmetric Strömgren sphere. The exact formation process of this nebula and its precise relation to the star's evolution remain unknown. Methods: We analyzed infrared Spitzer IRS and far-infrared Herschel/PACS observations of the NGC 6164/5 nebula. The Herschel imaging allowed us to constrain the global morphology of the nebula. We also combined the infrared spectra with optical spectra of the central star to constrain its evolutionary status. We used these data to derive the abundances in the ejected material. To relate this information to the evolutionary status of the star, we also determined the fundamental parameters of HD 148937 using the CMFGEN atmosphere code. Results: The Hα image displays a bipolar or "8"-shaped ionized nebula, whilst the infrared images show dust to be more concentrated around the central object. We determine nebular abundance ratios of N/O = 1.06 close to the star, and N/O = 1.54 in the bright lobe constituting NGC 6164. Interestingly, the parts of the nebula located further from HD 148937 appear more enriched in stellar material than the part located closer to the star. Evolutionary tracks suggest that these ejecta have occured 1.2-1.3 and 0.6 Myr ago, respectively. In addition, we derive abundances of argon for the nebula compatible with the solar values and we find a depletion of neon and sulfur. The combined analyses of the known kinematics and of the new abundances of the nebula suggest either a helical morphology for the nebula, possibly linked to the magnetic geometry, or the occurrence of a binary merger. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Based in part on observations collected at the European Southern Observatory, in Chile.

Interpretation of nasal swab measurements following suspected releases of actinide aerosols

DOE PAGES

Klumpp, John Allan; Bertelli, Luiz; Waters, Tom L.

2017-05-01

For radionuclides such as plutonium and americium, detection of removable activity in the nose (i.e., nasal swab measurements) are frequently used to determine whether follow-up bioassay measurements are warranted following a potential intake. For this paper, the authors analyzed 429 nasal swab measurements taken following incidents or suspicious circumstances (such as an air monitor alarming) at Los Alamos National Laboratory (LANL) for which the dose was later evaluated using in vitro bioassay. Nasal swab measurements were found to be very poor predictors of dose and should not be used as such in the field. However, nasal swab measurements can bemore » indicative of whether a reliably detectable committed effective dose (CED) occurred. About 14% of nasal swab measurements between 1.25 and 16.7 Bq corresponded to CEDs greater than 1 mSv, so in general, positive nasal swabs always indicate that follow-up bioassay should be performed (positive nasal swabs less than 1.25 Bq are considered separately). This probability increased significantly for nasal swabs greater than 16.7 Bq. Only about 3% of nasal swabs with no detectable activity (NDA) corresponded to reliably detectable CEDs. As a result, a nasal swab with NDA is therefore necessary, but not sufficient, to negate the need for a follow-up bioassay if it was collected following other workplace indicators of a potential intake.« less

Evaluation of the Community Multi-scale Air Quality (CMAQ) ...

EPA Pesticide Factsheets

The Community Multiscale Air Quality (CMAQ) model is a state-of-the-science air quality model that simulates the emission, transport and fate of numerous air pollutants, including ozone and particulate matter. The Computational Exposure Division (CED) of the U.S. Environmental Protection Agency develops the CMAQ model and periodically releases new versions of the model that include bug fixes and various other improvements to the modeling system. In the fall of 2015, CMAQ version 5.1 was released. This new version of CMAQ will contain important bug fixes to several issues that were identified in CMAQv5.0.2 and additionally include updates to other portions of the code. Several annual, and numerous episodic, CMAQv5.1 simulations were performed to assess the impact of these improvements on the model results. These results will be presented, along with a base evaluation of the performance of the CMAQv5.1 modeling system against available surface and upper-air measurements available during the time period simulated. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, proces

Engineering a vascularized collagen-β-tricalcium phosphate graft using an electrochemical approach.

PubMed

Kang, Yunqing; Mochizuki, Naoto; Khademhosseini, Ali; Fukuda, Junji; Yang, Yunzhi

2015-01-01

Vascularization of three-dimensional large synthetic grafts for tissue regeneration remains a significant challenge. Here we demonstrate an electrochemical approach, named the cell electrochemical detachment (CED) technique, to form an integral endothelium and use it to prevascularize a collagen-β-tricalcium phosphate (β-TCP) graft. The CED technique electrochemically detached an integral endothelium from a gold-coated glass rod to a collagen-infiltrated, channeled, macroporous β-TCP scaffold, forming an endothelium-lined microchannel containing graft upon removal of the rod. The in vitro results from static and perfusion culture showed that the endothelium robustly emanated microvascular sprouting and prevascularized the entire collagen/β-TCP integrated graft. The in vivo subcutaneous implantation studies showed that the prevascularized collagen/β-TCP grafts established blood flow originating from the endothelium-lined microchannel within a week, and the blood flow covered more areas in the graft over time. In addition, many blood vessels invaded the prevascularized collagen/β-TCP graft and the in vitro preformed microvascular networks anastomosed with the host vasculature, while collagen alone without the support of rigid ceramic scaffold showed less blood vessel invasion and anastomosis. These results suggest a promising strategy for effectively vascularizing large tissue-engineered grafts by integrating multiple hydrogel-based CED-engineered endothelium-lined microchannels into a rigid channeled macroporous scaffold. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Life cycle assessment of a power tower concentrating solar plant and the impacts of key design alternatives.

PubMed

Whitaker, Michael B; Heath, Garvin A; Burkhardt, John J; Turchi, Craig S

2013-06-04

A hybrid life cycle assessment (LCA) is used to evaluate four sustainability metrics over the life cycle of a power tower concentrating solar power (CSP) facility: greenhouse gas (GHG) emissions, water consumption, cumulative energy demand (CED), and energy payback time (EPBT). The reference design is for a dry-cooled, 106 MW(net) power tower facility located near Tucson, AZ that uses a mixture of mined nitrate salts as the heat transfer fluid and storage medium, a two-tank thermal energy storage system designed for six hours of full load-equivalent storage, and receives auxiliary power from the local electric grid. A thermocline-based storage system, synthetically derived salts, and natural gas auxiliary power are evaluated as design alternatives. Over its life cycle, the reference plant is estimated to have GHG emissions of 37 g CO2eq/kWh, consume 1.4 L/kWh of water and 0.49 MJ/kWh of energy, and have an EPBT of 15 months. Using synthetic salts is estimated to increase GHG emissions by 12%, CED by 7%, and water consumption by 4% compared to mined salts. Natural gas auxiliary power results in greater than 10% decreases in GHG emissions, water consumption, and CED. The thermocline design is most advantageous when coupled with the use of synthetic salts.

Galectins in Intestinal Inflammation: Galectin-1 Expression Delineates Response to Treatment in Celiac Disease Patients

PubMed Central

Sundblad, Victoria; Quintar, Amado A.; Morosi, Luciano G.; Niveloni, Sonia I.; Cabanne, Ana; Smecuol, Edgardo; Mauriño, Eduardo; Mariño, Karina V.; Bai, Julio C.; Maldonado, Cristina A.; Rabinovich, Gabriel A.

2018-01-01

Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex branched N-glycans and core 2-O-glycans, these endogenous lectins trigger distinct signaling programs thereby controling immune cell activation, differentiation, recruitment and survival. Given the unique features of mucosal inflammation and the differential expression of galectins throughout the gastrointestinal tract, we discuss here key findings on the role of galectins in intestinal inflammation, particularly Crohn’s disease, ulcerative colitis, and celiac disease (CeD) patients, as well as in murine models resembling these inflammatory conditions. In addition, we present new data highlighting the regulated expression of galectin-1 (Gal-1), a proto-type member of the galectin family, during intestinal inflammation in untreated and treated CeD patients. Our results unveil a substantial upregulation of Gal-1 accompanying the anti-inflammatory and tolerogenic response associated with gluten-free diet in CeD patients, suggesting a major role of this lectin in favoring resolution of inflammation and restoration of mucosal homeostasis. Thus, a coordinated network of galectins and their glycosylated ligands, exerting either anti-inflammatory or proinflammatory responses, may influence the interplay between intestinal epithelial cells and the highly specialized gut immune system in physiologic and pathologic settings. PMID:29545799

Galectins in Intestinal Inflammation: Galectin-1 Expression Delineates Response to Treatment in Celiac Disease Patients.

PubMed

Sundblad, Victoria; Quintar, Amado A; Morosi, Luciano G; Niveloni, Sonia I; Cabanne, Ana; Smecuol, Edgardo; Mauriño, Eduardo; Mariño, Karina V; Bai, Julio C; Maldonado, Cristina A; Rabinovich, Gabriel A

2018-01-01

Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex branched N-glycans and core 2-O-glycans, these endogenous lectins trigger distinct signaling programs thereby controling immune cell activation, differentiation, recruitment and survival. Given the unique features of mucosal inflammation and the differential expression of galectins throughout the gastrointestinal tract, we discuss here key findings on the role of galectins in intestinal inflammation, particularly Crohn's disease, ulcerative colitis, and celiac disease (CeD) patients, as well as in murine models resembling these inflammatory conditions. In addition, we present new data highlighting the regulated expression of galectin-1 (Gal-1), a proto-type member of the galectin family, during intestinal inflammation in untreated and treated CeD patients. Our results unveil a substantial upregulation of Gal-1 accompanying the anti-inflammatory and tolerogenic response associated with gluten-free diet in CeD patients, suggesting a major role of this lectin in favoring resolution of inflammation and restoration of mucosal homeostasis. Thus, a coordinated network of galectins and their glycosylated ligands, exerting either anti-inflammatory or proinflammatory responses, may influence the interplay between intestinal epithelial cells and the highly specialized gut immune system in physiologic and pathologic settings.

Convection-enhanced delivery of AAV2 in white matter--a novel method for gene delivery to cerebral cortex.

PubMed

Barua, N U; Woolley, M; Bienemann, A S; Johnson, D; Wyatt, M J; Irving, C; Lewis, O; Castrique, E; Gill, S S

2013-10-30

Convection-enhanced delivery (CED) is currently under investigation for delivering therapeutic agents to subcortical targets in the brain. Direct delivery of therapies to the cerebral cortex, however, remains a significant challenge. We describe a novel method of targeting adeno-associated viral vector (AAV) mediated gene therapies to specific cerebral cortical regions by performing high volume, high flow rate infusions into underlying white matter in a large animal (porcine) model. Infusion volumes of up to 700 μl at flow rates as high as 10 μl/min were successfully performed in white matter without adverse neurological sequelae. Co-infusion of AAV2/5-GFP with 0.2% Gadolinium in artificial CSF confirmed transgene expression in the deep layers of cerebral cortex overlying the infused areas of white matter. AAV-mediated gene therapies have been previously targeted to the cerebral cortex by performing intrathalamic CED and exploiting axonal transport. The novel method described in this study facilitates delivery of gene therapies to specific regions of the cerebral cortex without targeting deep brain structures. AAV-mediated gene therapies can be targeted to specific cortical regions by performing CED into underlying white matter. This technique could be applied to the treatment of neurological disorders characterised by cerebral cortical degeneration. Copyright © 2013 Elsevier B.V. All rights reserved.

Convection-enhanced delivery of MANF--volume of distribution analysis in porcine putamen and substantia nigra.

PubMed

Barua, N U; Bienemann, A S; Woolley, M; Wyatt, M J; Johnson, D; Lewis, O; Irving, C; Pritchard, G; Gill, S

2015-10-15

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a 20kDa human protein which has both neuroprotective and neurorestorative activity on dopaminergic neurons and therefore may have application for the treatment of Parkinson's Disease. The aims of this study were to determine the translational potential of convection-enhanced delivery (CED) of MANF for the treatment of PD by studying its distribution in porcine putamen and substantia nigra and to correlate histological distribution with co-infused gadolinium-DTPA using real-time magnetic resonance imaging. We describe the distribution of MANF in porcine putamen and substantia nigra using an implantable CED catheter system using co-infused gadolinium-DTPA to allow real-time MRI tracking of infusate distribution. The distribution of gadolinium-DTPA on MRI correlated well with immunohistochemical analysis of MANF distribution. Volumetric analysis of MANF IHC staining indicated a volume of infusion (Vi) to volume of distribution (Vd) ratio of 3 in putamen and 2 in substantia nigra. This study confirms the translational potential of CED of MANF as a novel treatment strategy in PD and also supports the co-infusion of gadolinium as a proxy measure of MANF distribution in future clinical studies. Further study is required to determine the optimum infusion regime, flow rate and frequency of infusions in human trials. Copyright © 2015 Elsevier B.V. All rights reserved.

Distribution of AAV-TK following intracranial convection-enhanced delivery into rats.

PubMed

Cunningham, J; Oiwa, Y; Nagy, D; Podsakoff, G; Colosi, P; Bankiewicz, K S

2000-01-01

Adeno-associated virus (AAV)-based vectors are being tested in animal models as viable treatments for glioma and neurodegenerative disease and could potentially be employed to target a variety of central nervous system disorders. The relationship between dose of injected vector and its resulting distribution in brain tissue has not been previously reported nor has the most efficient method of delivery been determined. Here we report that convection-enhanced delivery (CED) of 2.5 x 10(8), 2.5 x 10(9), or 2.5 x 10(10) particles of AAV-thymidine kinase (AAV-TK) into rat brain revealed a clear dose response. In the high-dose group, a volume of 300 mm3 of brain tissue was partially transduced. Results showed that infusion pump and subcutaneous osmotic pumps were both capable of delivering vector via CED and that total particle number was the most important determining factor in obtaining efficient expression. Results further showed differences in histopathology between the delivery groups. While administration of vector using infusion pump had relatively benign effects, the use of osmotic pumps resulted in notable toxicity to the surrounding brain tissue. To determine tissue distribution of vector following intracranial delivery, PCR analysis was performed on tissues from rats that received high doses of AAV-TK. Three weeks following CED, vector could be detected in both hemispheres of the brain, spinal cord, spleen, and kidney.

15 CFR 995.14 - Auditing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES CERTIFICATION REQUIREMENTS FOR DISTRIBUTORS OF NOAA HYDROGRAPHIC PRODUCTS Certification and Procedures § 995.14 Auditing. NOAA reserves the right to audit CED or...

15 CFR 995.14 - Auditing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES CERTIFICATION REQUIREMENTS FOR DISTRIBUTORS OF NOAA HYDROGRAPHIC PRODUCTS Certification and Procedures § 995.14 Auditing. NOAA reserves the right to audit CED or...

15 CFR 995.14 - Auditing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES CERTIFICATION REQUIREMENTS FOR DISTRIBUTORS OF NOAA HYDROGRAPHIC PRODUCTS Certification and Procedures § 995.14 Auditing. NOAA reserves the right to audit CED or...

15 CFR 995.14 - Auditing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... REQUIREMENTS FOR NOAA HYDROGRAPHIC PRODUCTS AND SERVICES CERTIFICATION REQUIREMENTS FOR DISTRIBUTORS OF NOAA HYDROGRAPHIC PRODUCTS Certification and Procedures § 995.14 Auditing. NOAA reserves the right to audit CED or...

The nature of the ionised nebula surrounding the red supergiant W26

NASA Astrophysics Data System (ADS)

Wesson, Roger

2015-08-01

The red supergiant W26 in the massive star cluster Westerlund 1 is surrounded by a compact ionised nebula. This is unique among RSGs, and the excitation mechanism of the nebula is not yet known - it may be ionised by an unseen compact companion, or by a nearby blue supergiant. We present new observations of the nebula: high resolution spatially resolved spectra taken with FLAMES at the VLT show that the nebula is a ring, with velocities consistent with that expected for red supergiant ejecta, and ruling out the possibility of a Luminous Blue Variable-type eruption preceding the RSG phase as the origin of the nebula. A triangular patch of nebulosity outside the ring appears to be associated with W26, and may be material stripped from the expanding ring by the cumulative cluster wind and radiation field.

A Smoking Gun in the Carina Nebula

NASA Technical Reports Server (NTRS)

Hamaguchi, Kenji; Corcoran, Michael F.; Ezoe, Yuichiro; Townsley, Leisa; Broos, Patrick; Gruendl, Robert; Vaidya, Kaushar; White, Stephen M.; Petre, Rob; Chu, You-Hua

2009-01-01

The Carina Nebula is one of thc youngest, most active sites of massive star formation in our Galaxy. In this nebula, we have discovered a bright X-ray source that has persisted for approx.30 years. The soft X-ray spectrum. consistent with kT approx.130 eV blackbody radiation with mild extinction, and no counterpart in the near- and mid-infrared wavelengths indicate that it is a, approx. 10(exp 6)-year-old neutron star housed in the Carina Nebula. Current star formation theory does not suggest that the progenitor of the neutron star and massive stars in the Carina Nebula, in particular (eta)Car, are coeval. This result demonstrates that the Carina Nebula experienced at least two major episodes of massive star formation. The neutron star would be responsible for remnants of high energy activity seen in multiple wavelengths.

Pulsar wind nebulae created by fast-moving pulsars

NASA Astrophysics Data System (ADS)

Kargaltsev, O.; Pavlov, G. G.; Klingler, N.; Rangelov, B.

2017-10-01

We review multiwavelength properties of pulsar wind nebulae created by supersonically moving pulsars and the effects of pulsar motion on the pulsar wind nebulae morphologies and the ambient medium. Supersonic pulsar wind nebulae are characterized by bow-shaped shocks around the pulsar and/or cometary tails filled with the shocked pulsar wind. In the past several years significant advances in supersonic pulsar wind nebula studies have been made in deep observations with the Chandra and XMM-Newton X-ray observatories and the Hubble Space Telescope. In particular, these observations have revealed very diverse supersonic pulsar wind nebula morphologies in the pulsar vicinity, different spectral behaviours of long pulsar tails, the presence of puzzling outflows misaligned with the pulsar velocity and far-UV bow shocks. Here we review the current observational status focusing on recent developments and their implications.

Final Blaze of Glory

NASA Technical Reports Server (NTRS)

2001-01-01

This video gives an overview of planetary nebulae through a computerized animation, images from the Hubble Space Telescope (HST), and interviews with Space Telescope Science Institute Theorist Dr. Mario Livio. A computerized animation simulates a giant star as it swallows its smaller companion. HST images display various planetary nebulae, such as M2-9 Twinjet Nebula, NGC 3568, NGC 3918, NGC 5307, NGC 6826, NGC 7009, and Hubble 5. An artist's concept shows what our solar system might look like in a billion years when the Sun has burned out and cast off its outer layers in a shell of glowing gas. Dr. Livio describes the shapes of the planetary nebulae, gives three reasons to study planetary nebulae, and what the observations made by HST have meant to him. A succession of 17 HST images of planetary nebulae are accompanied by music by John Serrie.

Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system.

PubMed

Han, Seunggu J; Bankiewicz, Krystof; Butowski, Nicholas A; Larson, Paul S; Aghi, Manish K

2016-06-01

Local delivery of therapeutic agents into the brain has many advantages; however, the inability to predict, visualize and confirm the infusion into the intended target has been a major hurdle in its clinical development. Here, we describe the current workflow and application of the interventional MRI (iMRI) system for catheter placement and real time visualization of infusion. We have applied real time convection-enhanced delivery (CED) of therapeutic agents with iMRI across a number of different clinical trials settings in neuro-oncology and movement disorders. Ongoing developments and accumulating experience with the technique and technology of drug formulations, CED platforms, and iMRI systems will continue to make local therapeutic delivery into the brain more accurate, efficient, effective and safer.

Imaging of convection enhanced delivery of toxins in humans.

PubMed

Mehta, Ankit I; Choi, Bryan D; Raghavan, Raghu; Brady, Martin; Friedman, Allan H; Bigner, Darell D; Pastan, Ira; Sampson, John H

2011-03-01

Drug delivery of immunotoxins to brain tumors circumventing the blood brain barrier is a significant challenge. Convection-enhanced delivery (CED) circumvents the blood brain barrier through direct intracerebral application using a hydrostatic pressure gradient to percolate therapeutic compounds throughout the interstitial spaces of infiltrated brain and tumors. The efficacy of CED is determined through the distribution of the therapeutic agent to the targeted region. The vast majority of patients fail to receive a significant amount of coverage of the area at risk for tumor recurrence. Understanding this challenge, it is surprising that so little work has been done to monitor the delivery of therapeutic agents using this novel approach. Here we present a review of imaging in convection enhanced delivery monitoring of toxins in humans, and discuss future challenges in the field.

Imaging of Convection Enhanced Delivery of Toxins in Humans

PubMed Central

Mehta, Ankit I.; Choi, Bryan D.; Raghavan, Raghu; Brady, Martin; Friedman, Allan H.; Bigner, Darell D.; Pastan, Ira; Sampson, John H.

2011-01-01

Drug delivery of immunotoxins to brain tumors circumventing the blood brain barrier is a significant challenge. Convection-enhanced delivery (CED) circumvents the blood brain barrier through direct intracerebral application using a hydrostatic pressure gradient to percolate therapeutic compounds throughout the interstitial spaces of infiltrated brain and tumors. The efficacy of CED is determined through the distribution of the therapeutic agent to the targeted region. The vast majority of patients fail to receive a significant amount of coverage of the area at risk for tumor recurrence. Understanding this challenge, it is surprising that so little work has been done to monitor the delivery of therapeutic agents using this novel approach. Here we present a review of imaging in convection enhanced delivery monitoring of toxins in humans, and discuss future challenges in the field. PMID:22069706

Impacts of Lateral Boundary Conditions on US Ozone ...

EPA Pesticide Factsheets

Chemical boundary conditions are a key input to regional-scale photochemical models. In this study, we perform annual simulations over North America with chemical boundary conditions prepared from two global models (GEOS-CHEM and Hemispheric CMAQ). Results indicate that the impacts of different boundary conditions on ozone can be significant throughout the year. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

Photometry and imaging of the peculiar planetary nebula IRAS 21282 + 5050

NASA Technical Reports Server (NTRS)

Kwok, Sun; Hrivnak, Bruce J.; Langill, Philip P.

1993-01-01

We report visible, near-infrared, and mid-infrared photometry of the IRAS planetary nebula 21282+ 5050. Narrow-band photometry at 10 microns confirms the presence of the 11.3-micron PAH feature. IRAS 21282+5050 belongs to a small group of planetary nebulae with WC11 nuclei and PAH emission. The spectral energy distribution shows that majority of the flux is emitted in the infrared, and the object has one of the highest infrared excesses among all planetary nebulae. Optical imaging (after subtraction of the central star) reveals a nebula of size of about 7 x 5 arcsec which is elongated along the N-S direction.

The SPM Kinematic Catalogue of Planetary Nebulae

NASA Astrophysics Data System (ADS)

López, J. A.; Richer, M. G.; Riesgo, H.; Steffen, W.; García-Segura, G.; Meaburn, J.; Bryce, M.

The San Pedro Mártir Kinematic Catalogue of Planetary Nebulae aims at providing detailed kinematic information for galactic planetary nebulae (PNe) and bright PNe in the Local Group. The database provides long-slit, Echelle spectra and images where the location of the slits on the nebula are indicated. As a tool to help interpret the 2D line profiles or position-velocity data, an atlas of synthetic emission line spectra accompanies the Catalogue. The atlas has been produced with the code SHAPE and contains synthetic spectra for all the main morphological groups for a wide range of spatial orientations and slit locations over the nebula.

Generation of dynamo magnetic fields in the primordial solar nebula

NASA Technical Reports Server (NTRS)

Stepinski, Tomasz F.

1992-01-01

The present treatment of dynamo-generated magnetic fields in the primordial solar nebula proceeds in view of the ability of the combined action of Keplerian rotation and helical convention to generate, via alpha-omega dynamo, large-scale magnetic fields in those parts of the nebula with sufficiently high, gas-and magnetic field coupling electrical conductivity. Nebular gas electrical conductivity and the radial distribution of the local dynamo number are calculated for both a viscous-accretion disk model and the quiescent-minimum mass nebula. It is found that magnetic fields can be easily generated and maintained by alpha-omega dynamos occupying the inner and outer parts of the nebula.

Photometric and spectroscopic study of low mass embedded star clusters in reflection nebulae

NASA Astrophysics Data System (ADS)

Soares, J. B.; Bica, E.; Ahumada, A. V.; Clariá, J. J.

2005-02-01

An analysis of the candidate embedded stellar systems in the reflection nebulae vdBH-RN 26, vdBH-RN} 38, vdBH-RN} 53a, GGD 20, ESO 95-RN 18 and NGC 6595 is presented. Optical spectroscopic data from CASLEO (Argentina) in conjunction with near infrared photometry from the 2MASS Point Source Catalogue were employed. The analysis is based on source surface density, colour-colour and colour-magnitude diagrams together with theoretical pre-main sequence isochrones. We take into account the field population affecting the analysis by carrying out a statistical subtraction. The fundamental parameters for the stellar systems were derived. The resulting ages are in the range 1-4 Myr and the objects are dominated by pre-main sequence stars. The observed masses locked in the clusters are less than 25 M⊙. The studied systems have no stars of spectral types earlier than B, indicating that star clusters do not necessarily evolve through an HII region phase. The relatively small locked mass combined with the fact that they are not numerous in catalogues suggests that these low mass clusters are not important donors of stars to the field populations. Based on observations made at Complejo Astronómico El Leoncito, which is operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the National Universities of La Plata, Córdoba and San Juan, Argentina.

A Flame in Orion Belt

NASA Image and Video Library

2010-12-02

This mosaic image taken by NASA Wide-field Infrared Survey Explorer, features three nebulae that are part of the giant Orion Molecular Cloud. Included in this view are the Flame nebula, the Horsehead nebula and NGC 2023.

A ROTATIONALLY POWERED MAGNETAR NEBULA AROUND SWIFT J1834.9–0846

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torres, Diego F.

A wind nebula generating extended X-ray emission was recently detected surrounding Swift J1834.9–0846. This is the first magnetar for which such a wind nebula was found. Here, we investigate whether there is a plausible scenario where the pulsar wind nebula (PWN) can be sustained without the need of advocating for additional sources of energy other than rotational. We do this by using a detailed radiative and dynamical code that studies the evolution of the nebula and its particle population in time. We find that such a scenario indeed exists: Swift J1834.9–0846's nebula can be explained as being rotationally powered, asmore » all other known PWNe are, if it is currently being compressed by the environment. The latter introduces several effects, the most important of which is the appearance of adiabatic heating, being increasingly dominant over the escape of particles as reverberation goes by. The need of reverberation naturally explains why this is the only magnetar nebula detected and provides estimates for Swift 1834.9–0846's age.« less

Nature versus nurture: Luminous blue variable nebulae in and near massive stellar clusters at the galactic center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lau, R. M.; Herter, T. L.; Adams, J. D.

Three luminous blue variables (LBVs) are located in and near the Quintuplet Cluster at the Galactic center: the Pistol Star, G0.120-0.048, and qF362. We present imaging at 19, 25, 31, and 37 μm of the region containing these three LBVs, obtained with SOFIA using FORCAST. We argue that Pistol and G0.120-0.048 are identical 'twins' that exhibit contrasting nebulae due to the external influence of their different environments. Our images reveal the asymmetric, compressed shell of hot dust surrounding the Pistol Star and provide the first detection of the thermal emission from the symmetric, hot dust envelope surrounding G0.120-0.048. However, nomore » detection of hot dust associated with qF362 is made. Dust and gas composing the Pistol nebula are primarily heated and ionized by the nearby Quintuplet Cluster stars. The northern region of the Pistol nebula is decelerated due to the interaction with the high-velocity (2000 km s{sup –1}) winds from adjacent Wolf-Rayet Carbon (WC) stars. From fits to the spectral energy distribution (SED) of the Pistol nebula with the DustEM code we determine that the Pistol nebula is composed of a distribution of very small, transiently heated grains (10 to ∼ 35 Å) having a total dust mass of 0.03 M {sub ☉}, and that it exhibits a gradient of decreasing grain size from south to north due to differential sputtering by the winds from the WC stars. The total IR luminosity of the Pistol nebula is 5.2 × 10{sup 5} L {sub ☉}. Dust in the G0.120-0.048 nebula is primarily heated by the central star; however, the nebular gas is ionized externally by the Arches Cluster. Unlike the Pistol nebula, the G0.120-0.048 nebula is freely expanding into the surrounding medium. A grain size distribution identical to that of the non-sputtered region of the Pistol nebula satisfies the constraints placed on the G0.120-0.048 nebula from DustEM model fits to its SED and implies a total dust mass of 0.021 M {sub ☉}. The total IR luminosity of the G0.120-0.048 nebula is ∼10{sup 5} L {sub ☉}. From Paschen-α and 6 cm observations we determine a total gas mass of 9.3 M {sub ☉} and 6.2 M {sub ☉} for the Pistol and G0.120-0.048 nebulae, respectively. Given the independent dust and gas mass estimates we find that the Pistol and G0.120-0.048 nebulae exhibit similar gas-to-dust mass ratios of 310{sub −52}{sup +77} and 293{sub −101}{sup +73}, respectively. Both nebulae share identical size scales (∼0.7 pc) which suggests that they have similar dynamical timescales of ∼10{sup 4} yr, assuming a shell expansion velocity of v {sub exp} = 60 km s{sup –1}.« less

What Else Did V. M. Slipher Do?

NASA Astrophysics Data System (ADS)

Tenn, J. S.

2013-04-01

When V. M. Slipher gave the 1933 George Darwin lecture to the Royal Astronomical Society, it was natural that he spoke on spectrographic studies of planets. Less than one-sixth of his published work deals with globular clusters and the objects we now call galaxies. In his most productive years, when he had Percival Lowell to give him direction, Slipher made major discoveries regarding stars, galactic nebulae, and solar system objects. These included the first spectroscopic measurement of the rotation period of Uranus, evidence that Venus's rotation is very slow, the existence of reflection nebulae and hence interstellar dust, and the stationary lines that prove the existence of interstellar calcium and sodium. After Lowell's death in 1916 Slipher continued making spectroscopic observations of planets, comets, and the aurora and night sky. He directed the Lowell Observatory from 1916 to 1954, where his greatest achievements were keeping the observatory running despite very limited staff and budget, and initiating and supervising the “successful” search for Lowell's Planet X. However, he did little science in his last decades, spending most of his time and energy on business endeavors.

Radio Observations of Elongated Pulsar Wind Nebulae

NASA Astrophysics Data System (ADS)

Ng, Stephen C.-Y.

2015-08-01

The majority of pulsars' rotational energy is carried away by relativistic winds, which are energetic particles accelerated in the magnetosphere. The confinement of the winds by the ambient medium result in synchrotron bubbles with broad-band emission, which are commonly referred to as pulsar wind nebulae (PWNe). Due to long synchrotron cooling time, a radio PWN reflects the integrated history of the system, complementing information obtained from the X-ray and higher energy bands. In addition, radio polarization measurements can offer a powerful probe of the PWN magnetic field structure. Altogether these can reveal the physical conditions and evolutionary history of a system.I report on preliminary results from high-resolution radio observations of PWNe associated with G327.1-1.1, PSRs J1015-5719, B1509-58, and J1549-4848 taken with the Australia Telescope Compact Array (ATCA). Their magnetic field structure and multiwavelength comparison with other observations are discussed.This work is supported by a ECS grant of the Hong Kong Government under HKU 709713P. The Australia Telescope is funded by the Commonwealth of Australia for operation as a National Facility managed by CSIRO.

The presence of clathrates in comet 67P/Churyumov-Gerasimenko

PubMed Central

Luspay-Kuti, Adrienn; Mousis, Olivier; Hässig, Myrtha; Fuselier, Stephen A.; Lunine, Jonathan I.; Marty, Bernard; Mandt, Kathleen E.; Wurz, Peter; Rubin, Martin

2016-01-01

Cometary nuclei are considered to most closely reflect the composition of the building blocks of our solar system. As such, comets carry important information about the prevalent conditions in the solar nebula before and after planet formation. Recent measurements of the time variation of major and minor volatile species in the coma of the Jupiter family comet 67P/Churyumov-Gerasimenko (67P) by the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) instrument onboard Rosetta provide insight into the possible origin of this comet. The observed outgassing pattern indicates that the nucleus of 67P contains crystalline ice, clathrates, and other ices. The observed outgassing is not consistent with gas release from an amorphous ice phase with trapped volatile gases. If the building blocks of 67P were formed from crystalline ices and clathrates, then 67P would have agglomerated from ices that were condensed and altered in the protosolar nebula closer to the Sun instead of more pristine ices originating from the interstellar medium or the outskirts of the disc, where amorphous ice may dominate. PMID:27152351

The presence of clathrates in comet 67P/Churyumov-Gerasimenko.

PubMed

Luspay-Kuti, Adrienn; Mousis, Olivier; Hässig, Myrtha; Fuselier, Stephen A; Lunine, Jonathan I; Marty, Bernard; Mandt, Kathleen E; Wurz, Peter; Rubin, Martin

2016-04-01

Cometary nuclei are considered to most closely reflect the composition of the building blocks of our solar system. As such, comets carry important information about the prevalent conditions in the solar nebula before and after planet formation. Recent measurements of the time variation of major and minor volatile species in the coma of the Jupiter family comet 67P/Churyumov-Gerasimenko (67P) by the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) instrument onboard Rosetta provide insight into the possible origin of this comet. The observed outgassing pattern indicates that the nucleus of 67P contains crystalline ice, clathrates, and other ices. The observed outgassing is not consistent with gas release from an amorphous ice phase with trapped volatile gases. If the building blocks of 67P were formed from crystalline ices and clathrates, then 67P would have agglomerated from ices that were condensed and altered in the protosolar nebula closer to the Sun instead of more pristine ices originating from the interstellar medium or the outskirts of the disc, where amorphous ice may dominate.

XMM-Newton RGS observations of the Cat's Eye Nebula

NASA Astrophysics Data System (ADS)

Guerrero, M. A.; Toalá, J. A.; Chu, Y.-H.; Gruendl, R. A.

2015-02-01

We present an analysis of XMM-Newton Reflection Grating Spectrometer (RGS) observations of the planetary nebula (PN) NGC 6543. These observations render it the second PN with high-resolution X-ray spectroscopic observations after BD +30°3639. The observations consist of 26 pointings, 14 of which included RGS observations for a total integration time of 435 ks. Many of these observations, however, were severely affected by high-background levels, and the net useful exposure time is drastically reduced to 25 ks. Only the O vii triplet at 22 Å is unambiguously detected in the RGS spectrum of NGC 6543. We find this spectrum consistent with an optically thin plasma at 0.147 keV (1.7 MK) and nebular abundances. Unlike BD +30°3639, the X-ray emission from NGC 6543 does not reveal overabundances of C and Ne. The results suggest that the N/O ratio of the hot plasma is consistent with that of the stellar wind, that is, it is lower than the nebular N/O ratio, but this result is not conclusive.

Convection Enhanced Delivery: A Comparison of infusion characteristics in ex vivo and in vivo non-human primate brain tissue.

PubMed

Miranpuri, Gurwattan; Hinchman, Angelica; Wang, Anyi; Schomberg, Dominic; Kubota, Ken; Brady, Martin; Raghavan, Raghu; Bruner, Kevin; Brodsky, Ethan; Block, Walter; Grabow, Ben; Raschke, Jim; Alexander, Andrew; Ross, Chris; Simmons, Heather; Sillay, Karl

2013-07-01

Convection enhanced delivery (CED) is emerging as a promising infusion toolto facilitate delivery of therapeutic agents into the brain via mechanically controlled pumps. Infusion protocols and catheter design have an important impact on delivery. CED is a valid alternative for systemic administration of agents in clinical trials for cell and gene therapies. Where gel and ex vivo models are not sufficient in modeling the disease, in vivo models allow researchers to better understand the underlying mechanisms of neuron degeneration, which is helpful in finding novel approaches to control the process or reverse the progression. Determining the risks, benefits, and efficacy of new gene therapies introduced via CED will pave a way to enter human clinical trial. The objective of this study is to compare volume distribution (Vd)/ volume infused (Vi) ratios and backflow measurements following CED infusions in ex vivo versus in vivo non-human primate brain tissue, based on infusion protocols developed in vitro. In ex vivo infusions, the first brain received 2 infusions using a balloon catheter at rates of 1 μL/min and 2 μL/min for 30 minutes. The second and third brains received infusions using a valve-tip (VT) catheter at 1 μL/min for 30 minutes. The fourth brain received a total of 45 μL infused at a rate of 1 μL/min for 15 minutes followed by 2 μL/min for 15 minutes. Imaging was performed (SPGR FA34) every 3 minutes. In the in vivo group, 4 subjects received a total of 8 infusions of 50 μL. Subjects 1 and 2 received infusions at 1.0 μL/min using a VT catheter in the left hemisphere and a smart-flow (SF) catheter in the right hemisphere. Subjects 3 and 4 each received 1 infusion in the left and right hemisphere at 1.0 μL/min. MRI calculations of Vd/Vi did not significantly differ from those obtained on post-mortem pathology. The mean measured Vd/Vi of in vivo (5.23 + /-1.67) compared to ex vivo (2.17 + /-1.39) demonstrated a significantly larger Vd/Vi for in vivo by 2.4 times (p = 0.0017). We detected higher ratios in the in vivo subjects than in ex vivo. This difference could be explained by the extra cellular space volume fraction. Studies evaluating backflow and morphology use in vivo tissue as a medium are recommended. Further investigation is warranted to evaluate the role blood pressure and heart rate may play in human CED clinical trials.

WISE Spies the Tarantula Nebula

NASA Image and Video Library

2010-07-06

Sending chills down the spine of all arachnophobes is the Tarantula nebula, seen in this image from NASA Wide-field Infrared Survey Explorer; the nebula is the largest star-forming region known in our entire Local Group of galaxies.

Soul Nebula

NASA Image and Video Library

2010-04-05

This mosaic from NASA WISE Telescope is of the Soul Nebula. It is an open cluster of stars surrounded by a cloud of dust and gas located about 6,500 light-years from Earth in the constellation Cassiopeia, near the Heart Nebula.

Weighing in on the Dumbbell Nebula

NASA Image and Video Library

2011-08-10

The Dumbbell nebula, also known as Messier 27, pumps out infrared light in this image from NASA Spitzer Space Telescope. Planetary nebulae are now known to be the remains of stars that once looked a lot like our sun.

An Audience Favorite Nebula

NASA Image and Video Library

2012-03-08

This nebula, which is in the constellation of Scutum, has no common name since it is hidden behind dust clouds. It takes an infrared telescope like NASA Spitzer to see through this dark veil and reveal this spectacular hidden nebula.

Herschel Sees Through Ghostly Pillars

NASA Image and Video Library

2012-01-18

This image of the Eagle nebula shows the self-emission of the intensely cold nebula gas and dust as never seen before; the nebula intricate tendril nature, with vast cavities forms an almost cave-like surrounding to the famous pillars.

Planetary Nebula NGC 7293 also Known as the Helix Nebula

NASA Image and Video Library

2005-05-05

This ultraviolet image from NASA Galaxy Evolution Explorer is of the planetary nebula NGC 7293 also known as the Helix Nebula. It is the nearest example of what happens to a star, like our own Sun, as it approaches the end of its life when it runs out of fuel, expels gas outward and evolves into a much hotter, smaller and denser white dwarf star. http://photojournal.jpl.nasa.gov/catalog/PIA07902

Solar nebula chemistry - Implications for volatiles in the solar system

NASA Technical Reports Server (NTRS)

Fegley, Bruce, Jr.; Prinn, Ronald G.

1989-01-01

Current theoretical models of solar nebula chemistry which take into account the interplay between chemistry and dynamics are presented for the abundant reactive volatile elements including hydrogen, carbon, nitrogen, oxygen, and sulfur. Results of these models indicate that, in the solar nebula, the dominant carbon and nitrogen gases were CO and NO, whereas, in giant planet subnebulae, the dominant carbon and nitrogen gases were CH4 and NH3; in the solar nebula, the Fe metal grains catalyzed the formation of organic compounds from CO and H2 via the Fischer-Tropsch-type reaction. It was also found that, in solar nebula, bulk FeS formation was kinetically favorable, while FeO incorporation into silicates and bulk Fe3O4 formation were kinetically inhibited. Furthermore, clathrate formation was kinetically inhibited in the solar nebula, while it was kinetically favorable in giant planet subnebulae.

Giant Hα Nebula Surrounding the Starburst Merger NGC 6240

NASA Astrophysics Data System (ADS)

Yoshida, Michitoshi; Yagi, Masafumi; Ohyama, Youichi; Komiyama, Yutaka; Kashikawa, Nobunari; Tanaka, Hisashi; Okamura, Sadanori

2016-03-01

We revealed the detailed structure of a vastly extended Hα-emitting nebula (“Hα nebula”) surrounding the starburst/merging galaxy NGC 6240 by deep narrow-band imaging observations with the Subaru Suprime-Cam. The extent of the nebula is ˜90 kpc in diameter and the total Hα luminosity amounts to LHα ≈ 1.6 × 1042 erg s-1. The volume filling factor and the mass of the warm ionized gas are ˜10-4-10-5 and ˜5 × 108 M⊙, respectively. The nebula has a complicated structure, which includes numerous filaments, loops, bubbles, and knots. We found that there is a tight spatial correlation between the Hα nebula and the extended soft-X-ray-emitting gas, both in large and small scales. The overall morphology of the nebula is dominated by filamentary structures radially extending from the center of the galaxy. A large-scale bipolar bubble extends along the minor axis of the main stellar disk. The morphology strongly suggests that the nebula was formed by intense outflows—superwinds—driven by starbursts. We also found three bright knots embedded in a looped filament of ionized gas that show head-tail morphologies in both emission-line and continuum, suggesting close interactions between the outflows and star-forming regions. Based on the morphology and surface brightness distribution of the Hα nebula, we propose the scenario that three major episodes of starburst/superwind activities, which were initiated ˜102 Myr ago, formed the extended ionized gas nebula of NGC 6240. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

WISE Catches the Lagoon Nebula in Center of Action

NASA Image and Video Library

2011-01-06

This colorful picture is a mosaic of Messier 8, or the Lagoon nebula, taken by NASA Wide-field Infrared Survey Explorer. This nebula is composed of clouds of gas and dust in which new stars are forming.

Into the Depths of the Lagoon Nebula

NASA Image and Video Library

2011-09-16

Swirling dust clouds and bright newborn stars dominate the view in this image of the Lagoon nebula from NASA Spitzer Space Telescope. The nebula lies in the general direction of the center of our galaxy in the constellation Sagittarius.

Trifid Nebula

NASA Image and Video Library

1999-12-02

Atlas Image mosaic, covering 14.8 x 20.0 on the sky, of the Trifid Nebula, aka Messier 20 and NGC 6514. The Trifid is only about 1.5 degrees northwest on the sky of the larger Lagoon Nebula Messier 8 in the constellation Sagittarius

A New View of the Tarantula Nebula

NASA Image and Video Library

2012-04-17

This composite of 30 Doradus, the Tarantula Nebula, contains data from Chandra blue, Hubble green, and Spitzer red. Located in the Large Magellanic Cloud, the Tarantula Nebula is one of the largest star-forming regions close to the Milky Way.

Quantifying and tracing sediment mobilized during the 20th century in the South River watershed, western Massachusetts

NASA Astrophysics Data System (ADS)

Dow, S.; Snyder, N. P.; Ouimet, W. B.; Martini, A. M.; Yellen, B.; Woodruff, J. D.; Newton, R. M.

2016-12-01

New England has a long history of anthropogenic activity affecting the landscape, including deforestation, land use changes, and the construction of dams. Dams in particular have the ability to impound vast quantities of sediment eroded off the landscape. The South River in western Massachusetts is an example of a watershed where mill dam construction coincided with deforestation during the 17th-19th centuries, leading to the impoundment of legacy sediment. Along the river, these deposits act as a source of sediment being released back into the river. The Conway Electric Dam (CED), a 17 m tall dam built in 1906, is located downstream of the mill dams (most of which are no longer intact), and provides a 20th century depositional record for the watershed. The purpose of this study is to quantify sedimentation behind the CED and link this to erosion of upstream mill pond and glacial sediment sources using aerial photography, sediment cores, grainsize, and geochemical analyses. We used aerial photographs to map areal changes of the reservoir from 1940-1980, and topographic profiles generated from LiDAR to estimate a volume of 244,000 m3 of sediment stored behind the CED. We dated layers in cores collected at the site with Hg and 137Cs analyses. Overall, the reservoir exhibits a decreasing rate of sediment infilling occurring from 1940-1980, except for a potentially anomalous increase from 1940-1952. Discharge data containing large storm events were compared to sediment infilling rates to identify if a frequency of large storms could account for high rates of erosion and sediment transport; however, sedimentation at the site does not appear to be solely dependent on these large storm events. Preliminary Hg analyses of deposits from the watershed upstream of the CED indicate higher concentrations in mill pond sediment than glacial sediment. Ongoing work with geochemical tracers can potentially provide a robust understanding of sources and 20th century sediment mobilization in the South River watershed, allowing us to quantify the influence of two cycles of dam construction on watershed sediment transport rates.

The DNA damage response of C. elegans affected by gravity sensing and radiosensitivity during the Shenzhou-8 spaceflight.

PubMed

Gao, Ying; Xu, Dan; Zhao, Lei; Sun, Yeqing

2017-01-01

Space radiation and microgravity are recognized as primary and inevitable risk factors for humans traveling in space, but the reports regarding their synergistic effects remain inconclusive and vary across studies due to differences in the environmental conditions and intrinsic biological sensitivity. Thus, we studied the synergistic effects on transcriptional changes in the global genome and DNA damage response (DDR) by using dys-1 mutant and ced-1 mutant of C. elegans, which respectively presented microgravity-insensitivity and radiosensitivity when exposure to spaceflight condition (SF) and space radiation (SR). The dys-1 mutation induced similar transcriptional changes under both conditions, including the transcriptional distribution and function of altered genes. The majority of alterations were related to metabolic shift under both conditions, including transmembrane transport, lipid metabolic processes and proteolysis. Under SF and SR conditions, 12/14 and 10/13 altered pathways, respectively, were both grouped in the metabolism category. Out of the 778 genes involved in DDR, except eya-1 and ceh-34, 28 altered genes in dys-1 mutant showed no predicted protein interactions, or anti-correlated miRNAs during spaceflight. The ced-1 mutation induced similar changes under SF and SR; however, these effects were stronger than those of the dys-1 mutant. The additional genes identified were related to phosphorous/phosphate metabolic processes and growth rather than, metabolism, especially for environmental information processing under SR. Although the DDR profiles were significantly changed under both conditions, the ced-1 mutation favored DNA repair under SF and apoptosis under SR. Notably, 37 miRNAs were predicted to be involved in the DDR. Our study indicates that, the dys-1 mutation reduced the transcriptional response to SF, and the ced-1 mutation increased the response to SR, when compared with the wild type C. elegans. Although some effects were due to radiosensitivity, microgravity, depending on the dystrophin, exerts predominant effects on transcription in C. elegans during short-duration spaceflight. Copyright © 2017 Elsevier B.V. All rights reserved.

Arctigenin Treatment Protects against Brain Damage through an Anti-Inflammatory and Anti-Apoptotic Mechanism after Needle Insertion

PubMed Central

Song, Jie; Li, Na; Xia, Yang; Gao, Zhong; Zou, Sa-feng; Kong, Liang; Yao, Ying-Jia; Jiao, Ya-Nan; Yan, Yu-Hui; Li, Shao-Heng; Tao, Zhen-Yu; Lian, Guan; Yang, Jing-Xian; Kang, Ting-Guo

2016-01-01

Convection enhanced delivery (CED) infuses drugs directly into brain tissue. Needle insertion is required and results in a stab wound injury (SWI). Subsequent secondary injury involves the release of inflammatory and apoptotic cytokines, which have dramatic consequences on the integrity of damaged tissue, leading to the evolution of a pericontusional-damaged area minutes to days after in the initial injury. The present study investigated the capacity for arctigenin (ARC) to prevent secondary brain injury and the determination of the underlying mechanism of action in a mouse model of SWI that mimics the process of CED. After CED, mice received a gavage of ARC from 30 min to 14 days. Neurological severity scores (NSS) and wound closure degree were assessed after the injury. Histological analysis and immunocytochemistry were used to evaluated the extent of brain damage and neuroinflammation. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was used to detect universal apoptosis. Enzyme-linked immunosorbent assays (ELISA) was used to test the inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10) and lactate dehydrogenase (LDH) content. Gene levels of inflammation (TNF-α, IL-6, and IL-10) and apoptosis (Caspase-3, Bax and Bcl-2) were detected by reverse transcription-polymerase chain reaction (RT-PCR). Using these, we analyzed ARC’s efficacy and mechanism of action. Results: ARC treatment improved neurological function by reducing brain water content and hematoma and accelerating wound closure relative to untreated mice. ARC treatment reduced the levels of TNF-α and IL-6 and the number of allograft inflammatory factor (IBA)- and myeloperoxidase (MPO)-positive cells and increased the levels of IL-10. ARC-treated mice had fewer TUNEL+ apoptotic neurons and activated caspase-3-positive neurons surrounding the lesion than controls, indicating increased neuronal survival. Conclusions: ARC treatment confers neuroprotection of brain tissue through anti-inflammatory and anti-apoptotic effects in a mouse model of SWI. These results suggest a new strategy for promoting neuronal survival and function after CED to improve long-term patient outcome. PMID:27445818

Papers presented to the Conference on Chondrules and the Protoplanetary Disk

NASA Technical Reports Server (NTRS)

1994-01-01

The following topics are covered in the presented papers: (1) producing chondrules; (2) carbons, CAI's, and chondrules; (3) large scale processes in the solar nebula; (4) chondrule-matrix relationships in chondritic meteorites; (5) overview of nebula models; (6) constraints placed on the nature of chondrule precursors; (7) turbulent diffusion and concentration of chondrules in the protoplanetary nebula; (8) heating and cooling in the solar nebula; (9) crystallization trends of precursor pyroxene in ordinary chondrites; (10) precipitation induced vertical lightning in the protoplanetary nebula; (11) the role of chondrules in nebular fractionations of volatiles and other elements; (12) astronomical observations of phenomena in disks; (13) experimental constraints on models for origins of chondrules, and various other topics.

The emerging planetary nebula CRL 618 and its unsettled central star(s)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balick, B.; Riera, A.; Raga, A.

We report deep long-slit emission-line spectra, the line flux ratios, and Doppler profile shapes of various bright optical lines. The low-ionization lines (primarily [N I], [O I], [S II], and [N II]) originate in shocked knots, as reported by many previous observers. Dust-scattered lines of higher ionization are seen throughout the lobes but do not peak in the knots. Our analysis of these line profiles and the readily discernible stellar continuum shows that (1) the central star is an active symbiotic (whose spectrum resembles the central stars of highly bipolar and young planetary nebulae such as M2-9 and Hen2-437) whosemore » compact companion shows a WC8-type spectrum, (2) extended nebular lines of [O III] and He I originate in the heavily obscured nuclear H II region, and (3) the Balmer lines observed throughout the lobes are dominated by reflected Hα emission from the symbiotic star. Comparing our line ratios with those observed historically shows that (1) the [O III]/Hβ and He I/Hβ ratios have been steadily rising by large amounts throughout the nebula, (2) the Hα/Hβ ratio is steadily decreasing while Hγ/Hβ remains nearly constant, and (3) the low-ionization line ratios formed in the shocked knots have been in decline in different ways at various locations. We show that the first two of these results might be expected if the symbiotic central star has been active and if its bright Hα line has faded significantly in the past 20 years.« less

A GLOWING POOL OF LIGHT

NASA Technical Reports Server (NTRS)

2002-01-01

NGC 3132 is a striking example of a planetary nebula. This expanding cloud of gas, surrounding a dying star, is known to amateur astronomers in the southern hemisphere as the 'Eight-Burst' or the 'Southern Ring' Nebula. The name 'planetary nebula' refers only to the round shape that many of these objects show when examined through a small visual telescope. In reality, these nebulae have little or nothing to do with planets, but are instead huge shells of gas ejected by stars as they near the ends of their lifetimes. NGC 3132 is nearly half a light year in diameter, and at a distance of about 2000 light years is one of the nearer known planetary nebulae. The gases are expanding away from the central star at a speed of 9 miles per second. This image, captured by NASA's Hubble Space Telescope, clearly shows two stars near the center of the nebula, a bright white one, and an adjacent, fainter companion to its upper right. (A third, unrelated star lies near the edge of the nebula.) The faint partner is actually the star that has ejected the nebula. This star is now smaller than our own Sun, but extremely hot. The flood of ultraviolet radiation from its surface makes the surrounding gases glow through fluorescence. The brighter star is in an earlier stage of stellar evolution, but in the future it will probably eject its own planetary nebula. In the Heritage Team's rendition of the Hubble image, the colors were chosen to represent the temperature of the gases. Blue represents the hottest gas, which is confined to the inner region of the nebula. Red represents the coolest gas, at the outer edge. The Hubble image also reveals a host of filaments, including one long one that resembles a waistband, made out of dust particles which have condensed out of the expanding gases. The dust particles are rich in elements such as carbon. Eons from now, these particles may be incorporated into new stars and planets when they form from interstellar gas and dust. Our own Sun may eject a similar planetary nebula some 6 billion years from now. Credit: Hubble Heritage Team (STScI/AURA/NASA)

A Cosmic Wreath

NASA Image and Video Library

2011-12-22

NASA Wide-field Infrared Survey Explorer mission presents the Wreath nebula. The nebula official name is Barnard 3, or IRAS Ring G159.6-18.5. Regions similar to this nebula are found near the band of the Milky Way galaxy in the night sky.

13 CFR 303.3 - Application requirements and evaluation criteria.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., DEPARTMENT OF COMMERCE PLANNING INVESTMENTS AND COMPREHENSIVE ECONOMIC DEVELOPMENT STRATEGIES § 303.3... involvement of the Region's business leadership at each stage of the preparation of the CEDS, short-term...

Planetary Nebula

NASA Image and Video Library

2017-12-08

This planetary nebula's simple, graceful appearance is thought to be due to perspective: our view from Earth looking straight into what is actually a barrel-shaped cloud of gas shrugged off by a dying central star. Hot blue gas near the energizing central star gives way to progressively cooler green and yellow gas at greater distances with the coolest red gas along the outer boundary. Credit: NASA/Hubble Heritage Team ---- The Ring Nebula's distinctive shape makes it a popular illustration for astronomy books. But new observations by NASA's Hubble Space Telescope of the glowing gas shroud around an old, dying, sun-like star reveal a new twist. "The nebula is not like a bagel, but rather, it's like a jelly doughnut, because it's filled with material in the middle," said C. Robert O'Dell of Vanderbilt University in Nashville, Tenn. He leads a research team that used Hubble and several ground-based telescopes to obtain the best view yet of the iconic nebula. The images show a more complex structure than astronomers once thought and have allowed them to construct the most precise 3-D model of the nebula. "With Hubble's detail, we see a completely different shape than what's been thought about historically for this classic nebula," O'Dell said. "The new Hubble observations show the nebula in much clearer detail, and we see things are not as simple as we previously thought." The Ring Nebula is about 2,000 light-years from Earth and measures roughly 1 light-year across. Located in the constellation Lyra, the nebula is a popular target for amateur astronomers. Read more: 1.usa.gov/14VAOMk NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Extended infrared emission around IRAS 21282 + 5050

NASA Technical Reports Server (NTRS)

Bregman, Jesse D.; Booth, John; Gilmore, D. K.; Kay, Laura; Rank, David

1992-01-01

Multiaperture 3-4-micron spectra along with K- and L-band images of the compact planetary nebula IRAS 21282 + 5050 show a 5 arcsec - 20 arcsec diameter nebula with structure similar to many other planetary nebulae. The spectral observations and the L-band image show evidence for extended PAH emission out to a radius of 20 arcsec, while the K-band image shows a 5 arcsec diameter nebula. An observed linear increase of integrated brightness with aperture size at L band implies a 1/r exp 2 volume emissivity for a spherically symmetric model. The spectral similarity of the emission in the small and large apertures suggests fluorescent emission by the PAHs. If the observed emission is from PAHs which formed during the planetary nebulae stage of IRAs 21282 + 5050, then PAHs have been forming for not less than 3000 yr. If the PAH emission is from material produced during the earlier red giant phase, then the formation time frame was much longer. The morphological and spectral similarity of IRAS 21282 + 5050 to many other planetary nebulae suggests that this phenomenon may be widespread, and that planetary nebulae may be a significant source of interstellar PAHs.

The Nature of the Stingray Nebula from Radio Observations

NASA Astrophysics Data System (ADS)

Harvey-Smith, Lisa; Hardwick, Jennifer A.; De Marco, Orsola; Parthasarathy, Mudumba; Gonidakis, Ioannis; Akhter, Shaila; Cunningham, Maria; Green, James A.

2018-06-01

We have analysed the full suite of Australia Telescope Compact Array data for the Stingray planetary nebula. Data were taken in the 4- to 23-GHz range of radio frequencies between 1991 and 2016. The radio flux density of the nebula generally declined during that period, but between 2013 and 2016 it shows signs of halting that decline. We produced the first spatially resolved radio images of the Stingray nebula from data taken in 2005. A ring structure, which appears to be associated with the ring seen in HST images, was visible. In addition, we found a narrow extension to the radio emission towards the eastern and western edges of the nebula. We derived the emission measure of the nebula - this decreased between 1992 and 2011, suggesting that the nebula is undergoing recombination. The radio spectral index is broadly consistent with a free-free emission mechanism, however a single data point hints that a steeper spectral index has possibly emerged since 2013, which could indicate the presence of synchrotron emission. If a non-thermal component component has emerged, such as one associated with a region that is launching a jet or outflow, we predict that it would intensify in the years to come.

New expansion rate measurements of the Crab nebula in radio and optical

NASA Astrophysics Data System (ADS)

Bietenholz, M. F.; Nugent, R. L.

2015-12-01

We present new radio measurements of the expansion rate of the Crab nebula's synchrotron nebula over a ˜30-yr period. We find a convergence date for the radio synchrotron nebula of CE 1255 ± 27. We also re-evaluated the expansion rate of the optical-line-emitting filaments, and we show that the traditional estimates of their convergence date are slightly biased. Using an unbiased Bayesian analysis, we find a convergence date for the filaments of CE 1091 ± 34 (˜40 yr earlier than previous estimates). Our results show that both the synchrotron nebula and the optical-line-emitting filaments have been accelerated since the explosion in CE 1054, but that the synchrotron nebula has been relatively strongly accelerated, while the optical filaments have been only slightly accelerated. The finding that the synchrotron emission expands more rapidly than the filaments supports the picture that the latter are the result of the Rayleigh-Taylor instability at the interface between the pulsar-wind nebula and the surrounding freely expanding supernova ejecta, and rules out models where the pulsar-wind bubble is interacting directly with the pre-supernova wind of the Crab's progenitor.

Observations of the planetary nebula RWT 152 with OSIRIS/GTC

NASA Astrophysics Data System (ADS)

Aller, A.; Miranda, L. F.; Olguín, L.; Solano, E.; Ulla, A.

2016-11-01

RWT 152 is one of the few known planetary nebulae with an sdO central star. We present subarcsecond red tunable filter Hα imaging and intermediate-resolution, long-slit spectroscopy of RWT 152 obtained with OSIRIS/GTC (Optical System for Imaging and low-Intermediate-Resolution Integrated Spectroscopy/Gran Telescopio Canarias) with the goal of analysing its properties. The Hα image reveals a bipolar nebula with a bright equatorial region and multiple bubbles in the main lobes. A faint circular halo surrounds the main nebula. The nebular spectra reveal a very low excitation nebula with weak emission lines from H+, He+ and double-ionized metals, and absence of emission lines from neutral and single-ionized metals, except for an extremely faint [N II] λ6584 emission line. These spectra may be explained if RWT 152 is a density-bounded planetary nebula. Low nebular chemical abundances of S, O, Ar, N and Ne are obtained in RWT 152, which, together with the derived high peculiar velocity (˜ 92-131 km s-1), indicate that this object is a halo planetary nebula. The available data are consistent with RWT 152 evolving from a low-mass progenitor (˜1 M⊙) formed in a metal-poor environment.

The mysterious age invariance of the planetary nebula luminosity function bright cut-off

NASA Astrophysics Data System (ADS)

Gesicki, K.; Zijlstra, A. A.; Miller Bertolami, M. M.

2018-05-01

Planetary nebulae mark the end of the active life of 90% of all stars. They trace the transition from a red giant to a degenerate white dwarf. Stellar models1,2 predicted that only stars above approximately twice the solar mass could form a bright nebula. But the ubiquitous presence of bright planetary nebulae in old stellar populations, such as elliptical galaxies, contradicts this: such high-mass stars are not present in old systems. The planetary nebula luminosity function, and especially its bright cut-off, is almost invariant between young spiral galaxies, with high-mass stars, and old elliptical galaxies, with only low-mass stars. Here, we show that new evolutionary tracks of low-mass stars are capable of explaining in a simple manner this decades-old mystery. The agreement between the observed luminosity function and computed stellar evolution validates the latest theoretical modelling. With these models, the planetary nebula luminosity function provides a powerful diagnostic to derive star formation histories of intermediate-age stars. The new models predict that the Sun at the end of its life will also form a planetary nebula, but it will be faint.

Identification of the Gum nebula as the fossil Stroemgren sphere of the Vela X supernova

NASA Technical Reports Server (NTRS)

Brandt, J. C.

1971-01-01

Evidence is presented for the production of the Gum nebula by the Vela X supernova, as opposed to its ionization by gamma Velorum and zeta Puppis. A model for the excitation of the nebula is proposed.

The Extended Region Around the Planetary Nebula NGC 3242

NASA Image and Video Library

2009-04-03

This ultraviolet image from NASA Galaxy Evolution Explorer shows NGC 3242, a planetary nebula frequently referred to as Jupiter Ghost. The small circular white and blue area at the center of the image is the well-known portion of the nebula.

Hubble Finds an Hourglass Nebula around a Dying Star

NASA Image and Video Library

1996-01-16

This Hubble telescope snapshot of MyCn18, a young planetary nebula, reveals that the object has an hourglass shape with an intricate pattern of etchings in its walls. A planetary nebula is the glowing relic of a dying, Sun-like star.

NGC 7293, the Helix Nebula

NASA Image and Video Library

2012-05-16

NGC 7293, better known as the Helix nebula, displays its ultraviolet glow courtesy of NASA GALEX. The Helix is the nearest example of a planetary nebula, which is the eventual fate of a star, like our own Sun, as it approaches the end of its life.

The First Detection of (O IV) from an Ultraluminous X-Ray Source with Spitzer. 2. Evidence for High Luminosity in Holmberg II ULX

DTIC Science & Technology

2010-01-01

from the accretion disk of the binary system and inconsistent with narrow beaming. We show that the emission nebula is matter- bounded both in the line...making them very dif- ficult to characterize. The ionization nebulae surrounding some ULXs have become critical for understanding the properties of...Abolmasov et al. 2007). It is located inside an ionized nebula (the “Foot nebula ”), and shows high- ionization optical emission lines coincident with

YSOVAR: Six Pre-main-sequence Eclipsing Binaries in the Orion Nebula Cluster

DTIC Science & Technology

2012-06-25

reserved. Printed in the U.S.A. YSOVAR: SIX PRE-MAIN-SEQUENCE ECLIPSING BINARIES IN THE ORION NEBULA CLUSTER M. Morales-Calderón1,2, J. R. Stauffer1, K. G...multi-color light curves for∼2400 candidate Orion Nebula Cluster (ONC) members from our Warm Spitzer Exploration Science Program YSOVAR, we have...readable tables 1. INTRODUCTION The Orion Nebula Cluster (ONC) contains several thousand members, and since it is nearby, it provides an excellent em

Spitzer Observations of MF 16 Nebula and the Associated Ultraluminous X-Ray Source

DTIC Science & Technology

2012-06-01

reserved. Printed in the U.S.A. SPITZER OBSERVATIONS OF MF 16 NEBULA AND THE ASSOCIATED ULTRALUMINOUS X-RAY SOURCE C. T. Berghea and R. P. Dudik United...associated nebula MF 16. This ULX has very similar properties to the famous Holmberg II ULX, the first ULX to show a prominent infrared [O iv] emission...the most interesting developments in ULX history is the discovery in recent years of large ionized bubble nebulae around some of the most famous ULXs

The ionization structure of planetary nebulae. IX - NGC 1535

NASA Technical Reports Server (NTRS)

Barker, Timothy

1989-01-01

The ionization structure of planetary nebula NGC 1535 was investigated using spectrophotometric observations of emission-line intensities over the spectral range 1400-7200 A, which were carried out in five positions in this nebula. The results obtained on the ionic abundances of He, O, N, Ne, C, and Ar in NGC 1535 suggest that it is a planetary nebula that formed initially in a somewhat metal-poor region and has undergone little or no enhancement of its original abundances by mixing with nuclear-processed material.

7 CFR 1220.605 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2014 CFR

2014-01-01

... SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions..., also referred to as “CED,” means the person employed by the FSA County Committee to execute the...

7 CFR 1220.605 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2012 CFR

2012-01-01

... SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions..., also referred to as “CED,” means the person employed by the FSA County Committee to execute the...

7 CFR 1220.605 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2013 CFR

2013-01-01

... SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions..., also referred to as “CED,” means the person employed by the FSA County Committee to execute the...

7 CFR 1220.605 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2011 CFR

2011-01-01

... SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions..., also referred to as “CED,” means the person employed by the FSA County Committee to execute the...

7 CFR 1220.605 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2010 CFR

2010-01-01

... SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures To Request a Referendum Definitions..., also referred to as “CED,” means the person employed by the FSA County Committee to execute the...

GIANT Hα NEBULA SURROUNDING THE STARBURST MERGER NGC 6240

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshida, Michitoshi; Yagi, Masafumi; Komiyama, Yutaka

We revealed the detailed structure of a vastly extended Hα-emitting nebula (“Hα nebula”) surrounding the starburst/merging galaxy NGC 6240 by deep narrow-band imaging observations with the Subaru Suprime-Cam. The extent of the nebula is ∼90 kpc in diameter and the total Hα luminosity amounts to L{sub Hα} ≈ 1.6 × 10{sup 42} erg s{sup −1}. The volume filling factor and the mass of the warm ionized gas are ∼10{sup −4}–10{sup −5} and ∼5 × 10{sup 8} M{sub ⊙}, respectively. The nebula has a complicated structure, which includes numerous filaments, loops, bubbles, and knots. We found that there is a tight spatial correlation between the Hαmore » nebula and the extended soft-X-ray-emitting gas, both in large and small scales. The overall morphology of the nebula is dominated by filamentary structures radially extending from the center of the galaxy. A large-scale bipolar bubble extends along the minor axis of the main stellar disk. The morphology strongly suggests that the nebula was formed by intense outflows—superwinds—driven by starbursts. We also found three bright knots embedded in a looped filament of ionized gas that show head-tail morphologies in both emission-line and continuum, suggesting close interactions between the outflows and star-forming regions. Based on the morphology and surface brightness distribution of the Hα nebula, we propose the scenario that three major episodes of starburst/superwind activities, which were initiated ∼10{sup 2} Myr ago, formed the extended ionized gas nebula of NGC 6240.« less

ALMA OBSERVATIONS OF THE COLDEST PLACE IN THE UNIVERSE: THE BOOMERANG NEBULA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sahai, R.; Vlemmings, W. H. T.; Huggins, P. J.

The Boomerang Nebula is the coldest known object in the universe, and an extreme member of the class of pre-planetary nebulae, objects which represent a short-lived transitional phase between the asymptotic giant branch and planetary nebula evolutionary stages. Previous single-dish CO (J = 1-0) observations (with a 45'' beam) showed that the high-speed outflow in this object has cooled to a temperature significantly below the temperature of the cosmic background radiation. Here we report the first observations of the Boomerang Nebula with ALMA in the CO J = 2-1 and J = 1-0 lines to resolve the structure of thismore » ultra-cold nebula. We find a central hourglass-shaped nebula surrounded by a patchy, but roughly round, cold high-velocity outflow. We compare the ALMA data with visible-light images obtained with the Hubble Space Telescope and confirm that the limb-brightened bipolar lobes seen in these data represent hollow cavities with dense walls of molecular gas and dust producing both the molecular-emission-line and scattered-light structures seen at millimeter and visible wavelengths. The large diffuse biconical shape of the nebula seen in the visible wavelength range is likely due to preferential illumination of the cold, high-velocity outflow. We find a compact source of millimeter-wave continuum in the nebular waist—these data, together with sensitive upper limits on the radio continuum using observations with ATCA, indicate the presence of a substantial mass of very large (millimeter-sized) grains in the waist of the nebula. Another unanticipated result is the detection of CO emission regions beyond the ultra-cold region which indicate the re-warming of the cold gas, most likely due to photoelectric grain heating.« less

ALMA Observations of the Coldest Place in the Universe: The Boomerang Nebula

NASA Astrophysics Data System (ADS)

Sahai, R.; Vlemmings, W. H. T.; Huggins, P. J.; Nyman, L.-Å.; Gonidakis, I.

2013-11-01

The Boomerang Nebula is the coldest known object in the universe, and an extreme member of the class of pre-planetary nebulae, objects which represent a short-lived transitional phase between the asymptotic giant branch and planetary nebula evolutionary stages. Previous single-dish CO (J = 1-0) observations (with a 45'' beam) showed that the high-speed outflow in this object has cooled to a temperature significantly below the temperature of the cosmic background radiation. Here we report the first observations of the Boomerang Nebula with ALMA in the CO J = 2-1 and J = 1-0 lines to resolve the structure of this ultra-cold nebula. We find a central hourglass-shaped nebula surrounded by a patchy, but roughly round, cold high-velocity outflow. We compare the ALMA data with visible-light images obtained with the Hubble Space Telescope and confirm that the limb-brightened bipolar lobes seen in these data represent hollow cavities with dense walls of molecular gas and dust producing both the molecular-emission-line and scattered-light structures seen at millimeter and visible wavelengths. The large diffuse biconical shape of the nebula seen in the visible wavelength range is likely due to preferential illumination of the cold, high-velocity outflow. We find a compact source of millimeter-wave continuum in the nebular waist—these data, together with sensitive upper limits on the radio continuum using observations with ATCA, indicate the presence of a substantial mass of very large (millimeter-sized) grains in the waist of the nebula. Another unanticipated result is the detection of CO emission regions beyond the ultra-cold region which indicate the re-warming of the cold gas, most likely due to photoelectric grain heating.

Nuclear Rocket Test Facility Decommissioning Including Controlled Explosive Demolition of a Neutron-Activated Shield Wall

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael Kruzic

2007-09-01

Located in Area 25 of the Nevada Test Site, the Test Cell A Facility was used in the 1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program. The facility was decontaminated and decommissioned (D&D) in 2005 using the Streamlined Approach For Environmental Restoration (SAFER) process, under the Federal Facilities Agreement and Consent Order (FFACO). Utilities and process piping were verified void of contents, hazardous materials were removed, concrete with removable contamination decontaminated, large sections mechanically demolished, and the remaining five-foot, five-inch thick radiologically-activated reinforced concrete shield wall demolished using open-air controlled explosive demolitionmore » (CED). CED of the shield wall was closely monitored and resulted in no radiological exposure or atmospheric release.« less

Cell Death in C. elegans Development.

PubMed

Malin, Jennifer Zuckerman; Shaham, Shai

2015-01-01

Cell death is a common and important feature of animal development, and cell death defects underlie many human disease states. The nematode Caenorhabditis elegans has proven fertile ground for uncovering molecular and cellular processes controlling programmed cell death. A core pathway consisting of the conserved proteins EGL-1/BH3-only, CED-9/BCL2, CED-4/APAF1, and CED-3/caspase promotes most cell death in the nematode, and a conserved set of proteins ensures the engulfment and degradation of dying cells. Multiple regulatory pathways control cell death onset in C. elegans, and many reveal similarities with tumor formation pathways in mammals, supporting the idea that cell death plays key roles in malignant progression. Nonetheless, a number of observations suggest that our understanding of developmental cell death in C. elegans is incomplete. The interaction between dying and engulfing cells seems to be more complex than originally appreciated, and it appears that key aspects of cell death initiation are not fully understood. It has also become apparent that the conserved apoptotic pathway is dispensable for the demise of the C. elegans linker cell, leading to the discovery of a previously unexplored gene program promoting cell death. Here, we review studies that formed the foundation of cell death research in C. elegans and describe new observations that expand, and in some cases remodel, this edifice. We raise the possibility that, in some cells, more than one death program may be needed to ensure cell death fidelity. © 2015 Elsevier Inc. All rights reserved.

The carbon budget in the outer solar nebula

NASA Technical Reports Server (NTRS)

Simonelli, Damon P.; Pollack, James B.; Mckay, Christopher P.; Reynolds, Ray T.; Summers, Audrey L.

1989-01-01

The compositional contrast between the giant-planet satellites and the significantly rockier Pluto/Charon system is indicative of different formation mechanisms; cosmic abundance calculations, in conjunction with an assumption of the Pluto/Charon system's direct formation from solar nebula condensates, strongly suggest that most of the carbon in the outer solar nebula was in CO form, in keeping with both the inheritance from the dense molecular clouds in the interstellar medium, and/or the Lewis and Prinn (1980) kinetic-inhibition model of solar nebula chemistry. Laboratory studies of carbonaceous chondrites and Comet Halley flyby studies suggest that condensed organic material, rather than elemental carbon, is the most likely candidate for the small percentage of the carbon-bearing solid in the outer solar nebula.

Dying Star Shrouded by a Blanket of Hailstones Forms the Bug Nebula

NASA Image and Video Library

2017-12-08

Release Date: May 3, 2004 A Dying Star Shrouded by a Blanket of Hailstones Forms the Bug Nebula (NGC 6302) The Bug Nebula, NGC 6302, is one of the brightest and most extreme planetary nebulae known. The fiery, dying star at its center is shrouded by a blanket of icy hailstones. This NASA Hubble Wide Field Plantery Camera 2 image shows impressive walls of compressed gas, laced with trailing strands and bubbling outflows. Object Names: NGC 6302, Bug Nebula Image Type: Astronomical Credit: NASA, ESA and A.Zijlstra (UMIST, Manchester, UK) To learn more about this image go to: hubblesite.org/gallery/album/nebula/pr2004046a/ NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Anomalous cosmic ray fluxes in diffusive shock acceleration processes in the heliosphere and in planetary and WR-nebulae

NASA Astrophysics Data System (ADS)

Yeghikyan, Ararat

2018-04-01

Based on the analogy between interacting stellar winds of planetary nebulae and WR-nebulae, on the one hand, and the heliosphere and the expanding envelopes of supernovae, on the other, an attempt is made to calculate the differential intensity of the energetic protons accelerated to energies of 100 MeV by the shock wave. The proposed one-parameter formula for estimating the intensity at 1-100 MeV, when applied to the heliosphere, shows good agreement with the Voyager-1 data, to within a factor of less than 2. The same estimate for planetary (and WR-) nebulae yields a value 7-8 (3-4) orders of magnitude higher than the mean galactic intensity value. The obtained estimate of the intensity of energetic protons in mentioned kinds of nebulae was used to estimate the doses of irradiation of certain substances, in order to show that such accelerated particles play an important role in radiation-chemical transformations in such nebulae.

Aggregates: The Fundamental Building Blocks of Planetesimals?

NASA Technical Reports Server (NTRS)

Cuzzi, J. N.; Hartlep, T.; Simon, J. I.; Cato, M. J.

2017-01-01

The initial accretion of primitive asteroids (meteorite parent bodies) from freely-floating nebula particles remains problematic. Traditional growth-by-sticking models in turbulent nebulae encounter a formidable "meter-size barrier" due to both drift and destruction, or even a mmtocmsize "bouncing" barrier. Even if growth by sticking could somehow breach these barriers (perhaps if the actual sticking or strength is larger than current estimates, which are based on pure ice or pure silicate), turbulent nebulae present further obstacles through the 1-10km size range. On the other hand, nonturbulent nebulae form large asteroids too quickly to explain long spreads in formation times, or the dearth of melted asteroids. Thus, the intensity of nebula turbulence (or "alpha ") is critical to the entire process. Theoretical understanding of nebula turbulence continues to evolve; while recent models of MRI (magneticallydriven) turbulence favor lowornoturbulence environments, purely hydrodynamic turbulence is making a comeback with three recently discovered mechanisms generating turbulence of moderate which do not rely on magnetic fields at all.

A morpho-kinematic and spectroscopic study of the bipolar nebulae: M 2-9, Mz 3, and Hen 2-104

NASA Astrophysics Data System (ADS)

Clyne, N.; Akras, S.; Steffen, W.; Redman, M. P.; Gonçalves, D. R.; Harvey, E.

2015-10-01

Context. Complex bipolar shapes can be generated either as a planetary nebula or a symbiotic system. The origin of the material ionised by the white dwarf is very different in these two scenarios, and it complicates the understanding of the morphologies of planetary nebulae. Aims: The physical properties, structure, and dynamics of the bipolar nebulae, M 2-9, Mz 3, and Hen 2-104, are investigated in detail with the aim of understanding their nature, shaping mechanisms, and evolutionary history. Both a morpho-kinematic study and a spectroscopic analysis, can be used to more accurately determine the kinematics and nature of each nebula. Methods: Long-slit optical echelle spectra are used to investigate the morpho-kinematics of M 2-9, Mz 3, and Hen 2-104. The morpho-kinematic modelling software SHAPE is used to constrain both the morphology and kinematics of each nebula by means of detailed 3D models. Near-infrared (NIR) data, as well as optical, spectra are used to separate Galactic symbiotic-type nebulae from genuine planetary nebulae by means of a 2MASS J-H/H-Ks diagram and a λ4363/Hγ vs. λ5007/Hβ diagnostic diagram, respectively. Results: The best-fitted 3D models for M 2-9, Mz 3, and Hen 2-104 provide invaluable kinematical information on the expansion velocity of its nebular components by means of synthetic spectra. The observed spectra match up very well with the synthetic spectra for each model, thus showing that each model is tightly constrained both morphologically and kinematically. Kinematical ages of the different structures of M 2-9 and Mz 3 have also been determined. Both diagnostic diagrams show M 2-9 and Hen 2-104 to fall well within the category of having a symbiotic source, whereas Mz 3 borders the region of symbiotic and young planetary nebulae in the optical diagram but is located firmly in the symbiotic region of the NIR colour-colour diagram. The optical diagnostic diagram is shown to successfully separate the two types of nebulae, however, the NIR colour-colour diagram is not as accurate in separating these objects. Conclusions: The morphology, kinematics, and evolutionary history of M 2-9, Mz 3, and Hen 2-104 are better understood using the interactive 3D modelling tool shape. The expansion velocities of the components for each nebula are better constrained and fitted with a vector field to reveal their direction of motion. The optical and NIR diagnostic diagrams used are important techniques for separating Galactic symbiotic-type nebulae from genuine planetary nebulae.

X-ray Emission from Hot Bubbles in nebulae around Evolved Stars

NASA Astrophysics Data System (ADS)

Toalá Sánz, Jesús Alberto

This thesis presents an observational and numerical study on the X-ray emission related to the formation and evolution from hot bubbles in nebulae around evolved stars. The observational part of this study consists mainly in observations obtained from the X-ray satellites X-ray Multi Mirror Mission (XMM-Newton) and Chandra X-ray Observatory (CXO). We have made use of optical, infrared, and ultraviolet observations that have complemented our results and analysis. These observations have allowed us to study the Wolf-Rayet (WR) nebulae S 308 and NGC 6888 and that around the WR star WR 16. We have also studied the planetary nebulae (PNe) NGC 6543 and Abell 78 (A 78). The X-ray telescopes, XMM-Newton and CXO, have allowed us to study the distribution and physical characteristics of the hot and diffuse gas in the WR nebulae S 308 and NGC 6888 with exquisite detail. Even though the CXO observations do not map entirely NGC 6888, we are able to estimate global parameters of the X-ray emission making use of ROSAT observations. Previous observations performed with were hampered by Suzaku, ROSAT, and ASCA were hampered by a large number of point sources in the line of sight of the nebulae. S 308 was observed with XMM-Newton with four pointings. We have made use of the most up-to-date tools for the analysis of soft and diffuse X-ray emission (the ESAS tasks). We found that in both nebulae the hot gas has a plasma temperature of 1-1.5×10^6 K and it is delineated by the [O III] emission and not the Hα as stated in previous studies. A notable difference between these two WR nebulae is that S 308 has a limb-brightened morphology in the distribution of its hot gas, while NGC 6888 displays three maxima. We have studied the WR nebula around WR 16 with archived XMM-Newton observations. Even though it was expected that diffuse X-ray emission should be detected from a spherical, non-disrupted WR nebula, by comparison with S 308 and NGC 6888, we are not able to detect such emission within this WR nebula. It is possible that hot gas exist inside the nebula, but with emissivity below detectable limits of the present generation of X-ray satellites. The Cat's Eye PN (a.k.a. NGC 6543) was also studied with XMM-Newton observations. We focused our analysis on observations from the Reflecting Grating Spectrometers (RGS1 and RGS2). We have been able to detect emission lines of ionized species of carbon, oxygen, and nitrogen. This makes NGC 6543 the second PN with high resolution spectroscopy observations apart from BD+30°3639. Finally, on observational grounds, we studied the born-again PN A78 with observations obtained during the realization of this thesis. This is the second born-again PNe to harbor a point-like X-ray emission plus a diffuse component. Such diffuse X-ray emission is the result of the complex interaction of the current fast stellar wind with the hydrogen-poor knots ejected in the born-again event. On the other hand, this thesis has been enriched with the realization of two-dimension (2D) radiative-hydrodynamic simulations. These simulations have been used to study the formation, evolution, and X-ray emission from PNe. With this, we have shown that the wind-wind interaction during the formation of PNe creates hydrodynamical instabilities that change the dynamics and observables (optical and X-ray) from the hot bubbles in PNe. This effect has been down-played by previous 1D (and analytical) works that have addressed the X-ray emission from PNe. As a result of such instabilities, we have shown that there is a difference in the hot bubble's size between models with and without thermal conduction. In the cases without such physical effect, the hot gas can leak through the gaps between clumps and filaments in the broken swept-up shell and this depressurises the bubble. The inclusion of thermal conduction evaporates and heats material from the clumpy shell, which expands to seal the gaps, preventing a loss in bubble pressure. The pressure in bubbles without conduction is dominated by the photoionized shell, while for bubbles with thermal conduction it is dominated by the hot, shocked wind. We extended this work by computing the synthetic X-ray emission from our numerical results. We find that even models without thermal conduction can mix material into the hot bubble via instabilities, which raises the emissivity of the bubbles to observable values. This is contrary to 1D models which need thermal conduction in order for the PN to be detected in X-rays. Furthermore, we can reproduce the temperatures as observed from X-ray studies.

A Self-Perpetuating Catalyst for the Production of Complex Organic Molecules in Protostellar Nebulae

NASA Technical Reports Server (NTRS)

Nuth, Joseph A.; Johnson, N. M.

2010-01-01

The formation of abundant carbonaceous material in meteorites is a long standing problem and an important factor in the debate on the potential for the origin of life in other stellar systems. Many mechanisms may contribute to the total organic content in protostellar nebulae, ranging from organics formed via ion-molecule and atom-molecule reactions in the cold dark clouds from which such nebulae collapse, to similar ion-molecule and atom-molecule reactions in the dark regions of the nebula far from the proto star, to gas phase reactions in sub-nebulae around growing giant planets and in the nebulae themselves. The Fischer-Tropsch-type (FTT) catalytic reduction of CO by hydrogen was once the preferred model for production of organic materials in the primitive solar nebula. The Haber-Bosch catalytic reduction of N2 by hydrogen was thought to produce the reduced nitrogen found in meteorites. However, the clean iron metal surfaces that catalyze these reactions are easily poisoned via reaction with any number of molecules, including the very same complex organics that they produce and both reactions work more efficiently in the hot regions of the nebula. We have demonstrated that many grain surfaces can catalyze both FTT and HB-type reactions, including amorphous iron and magnesium silicates, pure silica smokes as well as several minerals. Although none work as well as pure iron grains, and all produce a wide range of organic products rather than just pure methane, these materials are not truly catalysts.

The Herschel Planetary Nebula Survey (HerPlaNS). I. Data overview and analysis demonstration with NGC 6781

NASA Astrophysics Data System (ADS)

Ueta, T.; Ladjal, D.; Exter, K. M.; Otsuka, M.; Szczerba, R.; Siódmiak, N.; Aleman, I.; van Hoof, P. A. M.; Kastner, J. H.; Montez, R.; McDonald, I.; Wittkowski, M.; Sandin, C.; Ramstedt, S.; De Marco, O.; Villaver, E.; Chu, Y.-H.; Vlemmings, W.; Izumiura, H.; Sahai, R.; Lopez, J. A.; Balick, B.; Zijlstra, A.; Tielens, A. G. G. M.; Rattray, R. E.; Behar, E.; Blackman, E. G.; Hebden, K.; Hora, J. L.; Murakawa, K.; Nordhaus, J.; Nordon, R.; Yamamura, I.

2014-05-01

Context. This is the first of a series of investigations into far-IR characteristics of 11 planetary nebulae (PNe) under the Herschel Space Observatory open time 1 program, Herschel Planetary Nebula Survey (HerPlaNS). Aims: Using the HerPlaNS data set, we look into the PN energetics and variations of the physical conditions within the target nebulae. In the present work, we provide an overview of the survey, data acquisition and processing, and resulting data products. Methods: We performed (1) PACS/SPIRE broadband imaging to determine the spatial distribution of the cold dust component in the target PNe and (2) PACS/SPIRE spectral-energy-distribution and line spectroscopy to determine the spatial distribution of the gas component in the target PNe. Results: For the case of NGC 6781, the broadband maps confirm the nearly pole-on barrel structure of the amorphous carbon-rich dust shell and the surrounding halo having temperatures of 26-40 K. The PACS/SPIRE multiposition spectra show spatial variations of far-IR lines that reflect the physical stratification of the nebula. We demonstrate that spatially resolved far-IR line diagnostics yield the (Te, ne) profiles, from which distributions of ionized, atomic, and molecular gases can be determined. Direct comparison of the dust and gas column mass maps constrained by the HerPlaNS data allows to construct an empirical gas-to-dust mass ratio map, which shows a range of ratios with the median of 195 ± 110. The present analysis yields estimates of the total mass of the shell to be 0.86 M⊙, consisting of 0.54 M⊙ of ionized gas, 0.12 M⊙ of atomic gas, 0.2 M⊙ of molecular gas, and 4 × 10-3 M⊙ of dust grains. These estimates also suggest that the central star of about 1.5 M⊙ initial mass is terminating its PN evolution onto the white dwarf cooling track. Conclusions: The HerPlaNS data provide various diagnostics for both the dust and gas components in a spatially resolved manner. In the forthcoming papers of the HerPlaNS series we will explore the HerPlaNS data set fully for the entire sample of 11 PNe. Herschel is an ESA Space Observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Table 2 and appendices are available in electronic form at http://www.aanda.org

Transformation of Graphitic and Amorphous Carbon Dust to Complex Organic Molecules in a Massive Carbon Cycle in Protostellar Nebulae

NASA Technical Reports Server (NTRS)

Nuth, Joseph A., III; Johnson, Natasha M.

2012-01-01

More than 95% of silicate minerals and other oxides found in meteorites were melted, or vaporized and recondensed in the Solar Nebula prior to their incorporation into meteorite parent bodies. Gravitational accretion energy and heating via radioactive decay further transformed oxide minerals accreted into planetesimals. In such an oxygen-rich environment the carbonaceous dust that fell into the nebula as an intimate mixture with oxide grains should have been almost completely converted to CO. While some pre-collapse, molecular-cloud carbonaceous dust does survive, much in the same manner as do pre-solar oxide grains, such materials constitute only a few percent of meteoritic carbon and are clearly distinguished by elevated D/H, N-15/N-16, C-13/C-12 ratios or noble gas patterns. Carbonaceous Dust in Meteorites: We argue that nearly all of the carbon in meteorites was synthesized in the Solar Nebula from CO and that this CO was generated by the reaction of carbonaceous dust with solid oxides, water or OH. It is probable that some fraction of carbonaceous dust that is newly synthesized in the Solar Nebula is also converted back into CO by additional thermal processing. CO processing might occur on grains in the outer nebula through irradiation of CO-containing ice coatings or in the inner nebula via Fischer-Tropsch type (FTT) reactions on grain surfaces. Large-scale transport of both gaseous reaction products and dust from the inner nebula out to regions where comets formed would spread newly formed carbonaceous materials throughout the solar nebula. Formation of Organic Carbon: Carbon dust in the ISM might easily be described as inorganic graphite or amorphous carbon, with relatively low structural abundances of H, N, O and S . Products of FTT reactions or organics produced via irradiation of icy grains contain abundant aromatic and aliphatic hydrocarbons. aldehydes, keytones, acids, amines and amides.. The net result of the massive nebular carbon cycle is to convert relatively inert carbonaceous dust from the ISM into the vital organic precursors to life such as amino acids and sugars intimately mixed with dust and ice in primitive planetesimals. Since the number of carbon atoms entering the Solar Nebula as dust exceeds the number of atoms entering the nebula as oxide grains. the formation of large quantities of complex organic molecules may represent the largest single chemical cycle in the nebula.

SUBARU near-infrared multi-color images of Class II Young Stellar Object, RNO91

NASA Astrophysics Data System (ADS)

Mayama, Satoshi; Tamura, Motohide; Hayashi, Masahiko

RNO91 is class II source currently in a transition phase between a protostar and a main-sequence star. It is known as a source of complex molecular outflows. Previous studies suggested that RNO91 was associated with a reflection nebula, a CO outflow, shock-excited H[2] emission, and disk type structure. But geometry of RNO91, especially its inner region, is not well confirmed yet. High resolution imaging is needed to understand the nature of RNO91 and its interaction with outflow. Furthermore, RNO91 is an important candidate for studying YSOs in a transition phase. Thus, we conducted near-infrared imaging observations of RNO91 with the infrared camera CIAO mounted on the Subaru 8.2m Telescope. We present JHK band and optical images which resolve a complex asymmetrical circumstellar structure. We examined the color of RNO91 nebula and compare the geometry of the system suggested by our data with that already proposed on the basis of other studies. Our main results are as follows; 1. At J and optical, several bluer clumps are detected and they are aligned nearly perpendicular to the outflow axis. 2. The NIR images show significant halo emission detected within 2'' around the peak position while less halo emission is seen in the optical image. The nebula appears to become more circular and more diffuse with increasing wavelengths. The power-law dependence of radial surface brightness profile is shallower than that of normal stars, indicating that RNO91 is still optically thick objects. We suggest that the halo emission is the NIR light scattered by an optically thick disk or envelope surrounding the RNO91. 3. In the shorter wavelength images, the nebula appears to become more extended (2".3 long) to the southwest. This extended emission might trace a bottom of outflow emanating to southwest direction. 4. Color composite image of RNO91 reveals that the emission extending to the north and to the east through RNO91 is interpreted as a part of the cavity wall seen relatively edge-on. The northern ridge is 11" long and eastern ridge is 7" long.

Resolving the Circumstellar Environment of the Galactic B[e] Supergiant Star MWC 137 from Large to Small Scales

NASA Astrophysics Data System (ADS)

Kraus, Michaela; Liimets, Tiina; Cappa, Cristina E.; Cidale, Lydia S.; Nickeler, Dieter H.; Duronea, Nicolas U.; Arias, Maria L.; Gunawan, Diah S.; Oksala, Mary E.; Borges Fernandes, Marcelo; Maravelias, Grigoris; Curé, Michel; Santander-García, Miguel

2017-11-01

The Galactic object MWC 137 has been suggested to belong to the group of B[e] supergiants. However, with its large-scale optical bipolar ring nebula and high-velocity jet and knots, it is a rather atypical representative of this class. We performed multiwavelength observations spreading from the optical to the radio regimes. Based on optical imaging and long-slit spectroscopic data, we found that the northern parts of the large-scale nebula are predominantly blueshifted, while the southern regions appear mostly redshifted. We developed a geometrical model consisting of two double cones. Although various observational features can be approximated with such a scenario, the observed velocity pattern is more complex. Using near-infrared integral-field unit spectroscopy, we studied the hot molecular gas in the vicinity of the star. The emission from the hot CO gas arises in a small-scale disk revolving around the star on Keplerian orbits. Although the disk itself cannot be spatially resolved, its emission is reflected by the dust arranged in arc-like structures and the clumps surrounding MWC 137 on small scales. In the radio regime, we mapped the cold molecular gas in the outskirts of the optical nebula. We found that large amounts of cool molecular gas and warm dust embrace the optical nebula in the east, south, and west. No cold gas or dust was detected in the north and northwestern regions. Despite the new insights into the nebula kinematics gained from our studies, the real formation scenario of the large-scale nebula remains an open issue. Based on observations collected with (1) the ESO VLT Paranal Observatory under programs 094.D-0637(B) and 097.D-0033(A), (2) the MPG 2.2 m telescope at La Silla Observatory, Chile, under programs 096.A-9030(A) and 096.A-9039(A), (3) the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Science and Technology Facilities Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), Ministério da Ciência, Tecnologia e Inovação (Brazil), and Ministerio de Ciencia, Tecnología e Innovación Productiva (Argentina), under program GN-2013B-Q-11, (4) the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias, (5) the APEX telescope under the program CHILE-9711B-2016. APEX is a collaboration between the Max-Planck-Institut für Radioastronomie, the European Southern Observatory, and the Onsala Observatory, and (6) the Perek 2 m telescope at Ondřejov Observatory, Czech Republic.

The First Detection of (OIV) from an Ultraluminous X-Ray Source with Spitzer.I. Observational Results for Holmberg II ULX

DTIC Science & Technology

2009-12-11

nebulae of up to 500 pc diameter (Pakull & Mirioni 2002). These are much larger than regular supernova remnants (SNRs) and energy estimates show that...interaction of the ULX with the surrounding medium. Interestingly, SS 433 is also surrounded by a 100 pc radio nebula , W 50 (e.g., Fabrika 2004). Vázquez et al...ionization nebulae for investigating X-ray sources has long been realized, beginning with the first detection of nebulae around supersoft sources such

Astrometry With the Hubble Space Telescope: Trigonometric Parallaxes of Planetary Nebula Nuclei NGC 6853, NGC 7293, ABELL 31, and DeHt 5

DTIC Science & Technology

2009-12-01

reserved. Printed in the U.S.A. ASTROMETRY WITH THE HUBBLE SPACE TELESCOPE: TRIGONOMETRIC PARALLAXES OF PLANETARY NEBULA NUCLEI NGC 6853, NGC 7293, ABELL 31...present absolute parallaxes and relative proper motions for the central stars of the planetary nebulae NGC 6853 (The Dumbbell), NGC 7293 (The Helix...Abell 31, and DeHt 5. This paper details our reduction and analysis using DeHt 5 as an example. We obtain these planetary nebula nuclei (PNNi

Central Stars of Mid-Infrared Nebulae Discovered with Spitzer and WISE

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Kniazev, A. Y.

2017-02-01

Searches for compact mid-IR nebulae with the Spitzer Space Telescope and the Wide-field Infrared Survey Explorer (WISE), accompanied by spectroscopic observations of central stars of these nebulae led to the discovery of many dozens of massive stars at different evolutionary stages, of which the most numerous are candidate luminous blue variables (LBVs). In this paper, we give a census of candidate and confirmed Galactic LBVs revealed with Spitzer and WISE, and present some new results of spectroscopic observations of central stars of mid-IR nebulae.

A survey for PAH emission in H II regions, planetary and proto-planetary nebulae

NASA Technical Reports Server (NTRS)

Demuizon, M.; Cox, P.; Lequeux, J.

1989-01-01

The results of a systematic investigation of polycyclic aromatic hydrocarbon (PAH) emission in H II regions, planetary nebulae (PN), and proto-planetary nebulae (PNN), are reported. Data is obtained from the low resolution spectra (LRS) of IRAS. The results show that: PAHs are formed in carbon rich objects; and PAH emission is ubiquitous in general interstellar medium and requires the presence of ultraviolet photons, in planetary and proto-planetary nebulae, PAH emission is seen only where an ionizing flux is present and in carbon rich objects.

VizieR Online Data Catalog: MYStIX: the Chandra X-ray sources (Kuhn+, 2013)

NASA Astrophysics Data System (ADS)

Kuhn, M. A.; Getman, K. V.; Broos, P. S.; Townsley, L. K.; Feigelson, E. D.

2013-11-01

X-ray observations were made with the imaging array on the Advanced CCD Imaging Spectrometer (ACIS-I) on board the Chandra X-Ray Observatory. This array of four CCD detectors subtends 17'x17' on the sky. Data were acquired from the Chandra Data Archive from 2001 Jan to Mar 2008 for 10 MYStIX fields (Flame Nebula, RCW 36, NGC 2264, Rosette Nebula, Lagoon Nebula, NGC 2362, DR 21, RCW 38, Trifid Nebula and NGC 1893); see table1. (2 data files).

Ultraviolet spectra of planetary nebulae. X - Physical conditions in the compact planetary nebula Sw St 1

NASA Technical Reports Server (NTRS)

Flower, D. R.; Goharji, A.; Cohen, M.

1984-01-01

Photoelectric visual and ultraviolet observations of the compact planetary nebula Sw St 1 are analyzed. The electron density, determined from the C III 1907/1909 A line ratio, is N(e) = (1.1 + or - 0.1) x 10 to the 5th/cu cm, consistent with the high emission measure and high critical frequency determined from observations of the thermal radio emission. The C/O abundance ratio in the nebula is found to be N(C)/N(O) = 0.72 + or - 0.1, i.e. the envelope is oxygen-rich, as suggested by the identification of the silicate feature in the 8-13 micron infrared spectrum. Difficulties remain in accurately determining the reddening constant to the nebula and its electron temperature.

New Radio and Optical Expansion Rate Measurements of the Crab Nebula

NASA Astrophysics Data System (ADS)

Bietenholz, M. F.; Nugent, R. L.

2016-06-01

We present new JVLA radio observations of the Crab nebula, which we use, along with older observations taken over a ~30 yr period, to determined the expansion rate of the synchrotron nebula. We find a convergence date for the radio synchrotron nebula of AD 1255 +/- 27. We also re-evaluated the expansion rate of the optical line emitting filaments, and we show that the traditional estimates of their convergence date are slightly biased. We find an un-biased convergence date of AD 1091 +/- 34, ~40 yr earlier than previous estimates. Our results show that both the synchrotron nebula and the optical line-emitting filaments have been accelerated since the explosion in AD 1054, but former more strongly than the latter. This finding supports the picture that the filaments are the result of the Rayleigh-Taylor instability at the interface between the pulsar-wind nebula and the surrounding freely-expanding supernova ejecta, and rules out models where the pulsar wind bubble is interacting directly with the pre-supernova wind of the Crab's progenitor. Our new observations were taken ~2 months after the gamma-ray flare of 2012 July, and also allow us to put a sensitive limit on any radio emission associated with the flare of <0.0002 times the radio luminosity that of the nebula.

Ring Beholds a Delicate Flower

NASA Technical Reports Server (NTRS)

2005-01-01

NASA's Spitzer Space Telescope finds a delicate flower in the Ring Nebula, as shown in this image. The outer shell of this planetary nebula looks surprisingly similar to the delicate petals of a camellia blossom. A planetary nebula is a shell of material ejected from a dying star. Located about 2,000 light years from Earth in the constellation Lyra, the Ring Nebula is also known as Messier Object 57 and NGC 6720. It is one of the best examples of a planetary nebula and a favorite target of amateur astronomers.

The 'ring' is a thick cylinder of glowing gas and dust around the doomed star. As the star begins to run out of fuel, its core becomes smaller and hotter, boiling off its outer layers. The telescope's infrared array camera detected this material expelled from the withering star. Previous images of the Ring Nebula taken by visible-light telescopes usually showed just the inner glowing loop of gas around the star. The outer regions are especially prominent in this new image because Spitzer sees the infrared light from hydrogen molecules. The molecules emit infrared light because they have absorbed ultraviolet radiation from the star or have been heated by the wind from the star.

Download the QuickTime movie for the animated version of this Ring Nebula image.

Polarization due to dust scattering in the planetary nebula Cn1-1

NASA Technical Reports Server (NTRS)

Bhatt, Harish C.

1989-01-01

The peculiar emission-line object Cn1-1 (=HDE330036=PK330+4 degrees 1), classified both as a symbiotic star and as a planetary nebula, was detected by the Infrared Astronomical Satellite (IRAS) as a strong source of far-infrared dust in the system. Bhatt and Mallik (1986) discussed the nature of the dust in Cn1-1 and argued that the object is a Type I protoplanetary nebula in a binary system. The argument presented here is that the polarization is intrinsic to Cn1-1 and is due to scattering by large (compared to interstellar) dust grains in the protoplanetary nebula that are asymmetrically distributed around the central star. The large degree of polarization (approximately 3 percent for the Cn1-1 distance of approximately 450 pc) with a large lambda(sub max) is naturally explained if it is caused by scattering by large dust grains in the Cn1-1 nebula. Since the H(sub alpha) line is also polarized at the same level and position angle as the continuum, the dust must be asymmetrically distributed around the central star. The morphology of the protoplanetary nebula in Cn1-1 may be bipolar. Thus, the polarization observations support the suggestion that Cn1-1 is a bipolar Type I planetary nebula.

On the peculiar shapes of some pulsar bow-shock nebulae

NASA Astrophysics Data System (ADS)

Bandiera, Rino

Pulsar bow-shock nebulae are pulsar-wind nebulae formed by the direct interaction of pulsar relativistic winds with the interstellar medium. The bow-shock morphology, well outlined in Hα for some objects, is an effect of the supersonic pulsar motion with respect to the ambient medium. However, in a considerable fraction of cases (e.g. the nebulae associated to PSR B2224+65, PSR B0740-28, PSR J2124-3358) clear deviations from the classical bow shock shape are observed. Such deviations are usually interpreted as due to ambient density gradients and/or to pulsar-wind anisotropies. Here I present a different interpretation, aiming at explaining deviations from the standard morphology as signs of the peculiar physical conditions present in these objects. Using dimensional arguments, I show that, unlike normal pulsar-wind nebulae, in pulsar bow-shock nebulae the mean free path of the highest-energy particles may be comparable with the bow-shock head. I then investigate whether this may affect the shape of the bow-shock; for instance, whether a conical bow shock (like that observed in the "Guitar", the nebula associated to PSR B2224+65) does really imply an ambient density gradient. Finally, I discuss some other possible signatures of these high-energy, long mean-free-path particles.

The Photoluminescence Efficiency of Extended Red Emission as a Constraint for Interstellar Dust

NASA Astrophysics Data System (ADS)

Smith, T. L.; Witt, A. N.

1999-12-01

The broad, 60 < FWHM < 100 nm, featureless luminescence band known as extended red emission (ERE) is seen in such diverse dusty astrophysical environments as reflection nebulae 17, planetary nebulae 3, HII regions (Orion) 12, a Nova 11, Galactic cirrus 14, a dark nebula 7, Galaxies 8,6 and the diffuse interstellar medium (ISM) 4. The band is confined between 540-950 nm, but the wavelength of peak emission varies from environment to environment, even within a given object. We have concluded that available data indicate that the wavelength of peak emission is longer and the efficiency of the luminescence is lower, the harder and denser the illuminating radiation field is 13. These general characteristics of ERE constrain the photoluminescence (PL) band and efficiency for laboratory analysis of dust analog materials. We have studied and present the PL band characteristics and efficiencies for a wide variety of dust analogs including hydrogenated amorphous carbon (HAC), Si-HAC alloys, nanodiamonds, silicon carbide nanoparticles, carbon nanoparticles and silicon nanoparticles. The PL efficiencies measured for HAC and Si-HAC alloys are consistent with dust estimates for reflection nebulae and planetary nebulae, but exhibit substantial photoluminescence below 540 nm which is not observed in astrophysical environments. Furthermore, all interstellar grains would need to consist of or be coated with these materials to match the ERE in terms of its quantum efficiency. Only the experimentally confirmed photoluminescence properties of silicon nanoparticles 1,2,5,9,10,15,16 match the ERE photoluminescence band constraints and fulfill the minimum photoluminescence efficiency predicted by Gordon et al. (1998) 4 without introducing unexpected spectral features in the diffuse ISM and without violating the abundance constraints on depleted interstellar silicon 18. This work has been supported by grants from NASA which we acknowledge with gratitude. 1. Credo, G.M., Mason, M.D., & Burrato, S.K. 1999, Appl. Phys. Lett., 74, 1978 2. Ehbrecht, M., Kohn, B., Huisken, F., Laguna, M.A. & Paillard, V. 1997, Phys. Rev. B, 56, 6958 3. Furton, D.G., & Witt, A.N. 1992, ApJ, 386, 587 4. Gordon, K.D., Witt, A.N., & Friedmann, B.C. 1998, ApJ, 498, 522 5. Lockwood, D.J., Lu, Z.H., & Baribeau, J.M. 1996, Phys. Rev. Lett., 76, 539 6. Majeed, A., Witt, A.N., & Boroson, T.A. 1999, Bull. AAS 3,886 7. Mattila, K. 1979, A&A, 78, 253 8. Perrin, J.M., Darbon, S., & Sivan, J.P. 1995, A&A, 304, L21 9. Schuppler, S. et al. 1994, Phys. Rev. B, 56, 6958 10. Schuppler, S. et al. 1995, Phys. Rev. B, 52, 4910 11. Scott, A.D., Evans, A., & Rawlings, J.M.C. 1994, MNRAS, 269, L21 12. Sivan, J.P., & Perrin, J.M. 1993, ApJ, 404, 258 13. Smith, T.L., Witt, A.N. & Gordon, K.D. 1999, BAAS 71.13 14. Szomoru, A., & Guhathakurta, P. 1998, ApJ, 494, L93 15. von Behren, J. van Buuren, T., Zacharias, M., Chimowitz, & E.H. Fauchet,P.M. 1998, Solid State Comm., 105, 317 16. Wilson, W.L., Szajowski, P.F., & Brus, L.E. 1993, Science, 262, 1242 17. Witt, A.N., & Boroson T.A. 1990, ApJ, 355, 182 18. Zubko, V.G. Smith, T.L., & Witt, A.N. 1999, ApJ, 511, L57

The remarkable Red Rectangle: A Stairway to Heaven?

NASA Astrophysics Data System (ADS)

2004-05-01

HD 44179 Nebula hi-res Size hi-res: 865 Kb Credits: NASA/ESA, Hans Van Winckel (Catholic University of Leuven, Belgium) and Martin Cohen (University of California) The HD 44179 nebula, known as the 'Red Rectangle.' This image, taken with the NASA/ESA Hubble Space Telescope, reveals startling new details of one of the most unusual nebulae known in our galaxy. Catalogued as HD 44179, this nebula is more commonly called the 'Red Rectangle' because of its unique shape and colour as seen with ground-based telescopes. Hubble has revealed a wealth of new features in the Red Rectangle that cannot be seen by ground-based telescopes looking through Earth’s turbulent atmosphere. Details of the Hubble study were published in the April 2004 issue of The Astronomical Journal. HD 44179 Nebula hi-res Size hi-res: 1289 Kb Credits: ESA and Vincent Icke (Leiden University, the Netherlands) Simulating the Red Rectangle The NASA/ESA Hubble Space Telescope has revealed a wealth of new features in the Red Rectangle that cannot be seen with ground-based telescopes looking through the Earth’s turbulent atmosphere. Whereas the origins of many of the features in this dying star still remain hidden or even outright mysterious, some are well explained by theorists like the Dutch scientist Vincent Icke from Leiden University in the Netherlands. In 1981 Vincent Icke and collaborators showed that a spherical gas ejection from a dying star hitting a dust torus would give rise to shocks that can produce cone-like outflows similar to the two cones seen in the Hubble image. Meteorologists produce weather forecasts by advanced calculations of temperatures, pressures, velocities and densities for the air masses in our atmosphere and, to some degree, theorists like Icke are doing exactly the same for objects in space. Whether modelling the weather in the Earth’s atmosphere or the processes in distant gaseous nebulae, scientists calculate the motion of the gas by using a complicated set of expressions known as hydrodynamic equations. Most of the matter in the Universe is in the form of gas. The weather on Earth gives rise to spectacular patterns such as thunderclouds and tornadoes in the air masses here. Likewise, the ‘weather’ in gas clouds in space, like the Red Rectangle, can be fascinating. Of the many different parameters in Vincent Icke’s calculations, only the density of the gas and the dust are observed in the Hubble image. The reflection of the gas and dust are shown in this simulated image. The colours show what one would see in scattered light - blue light scatters more than red. The ejected blobs of gas and dust look reddish, the background nebula is whiter. The three images are a time sequence with about 600 years between and show how the Red Rectangle may have been created. HD 44179 Nebula hi-res Size hi-res: 4550 Kb Credits: ESA and Digitized Sky Survey 2 Red Rectangle overview image 1 This is a ground-based view of the sky around the Red Rectangle. The image spans a square of one degree and was constructed from three images from the Digitized Sky Survey 2 taken in blue, infrared and red (shown as blue, green and red respectively). HD 44179 Nebula hi-res Size hi-res: 479 Kb Credits: ESA, ESO and Hans van Winckel (Catholic University of Leuven, Belgium) Red Rectangle overview image 2 This ground-based image was taken with the European Southern Observatory’s New Technology Telescope at La Silla Observatory. The image is constructed from three exposures through a blue filter, hydrogen-alpha filter and a red filter. This image, taken with the NASA/ESA Hubble Space Telescope, reveals startling new details of one of the most unusual nebulae known in our galaxy. Catalogued as HD 44179, this nebula is more commonly called the 'Red Rectangle' because of its unique shape and colour as seen with ground-based telescopes. Hubble has revealed a wealth of new features in the Red Rectangle that cannot be seen by ground-based telescopes looking through the Earth’s turbulent atmosphere. Details of the Hubble study were published in the April 2004 issue of The Astronomical Journal. Hans Van Winckel (Catholic University of Leuven, Belgium), the principal investigator for the Hubble observations, says: “The structure of the Red Rectangle revealed by Hubble is surprisingly complex. The features that impress me most look like the rungs of a ladder, although they are actually projections of gas cones, like a series of nested wine glasses filled to their brim with gas and seen from the side.” Hubble's sharp pictures show that the Red Rectangle is not really rectangular, but has an X-shaped structure, that astronomers interpret as arising from outflows of gas and dust from the star in the centre. The cone-like outflows are ejected from the star in two opposing directions. In addition there are straight linking features that look like the rungs on a ladder, making the Red Rectangle look similar to a spider’s web, a shape unlike that of any other known nebula in the sky. These rungs may have arisen in episodes of mass ejection from the star that occur every few hundred years and could represent a series of ‘smoke rings’, seen almost exactly edge-on from our vantage point. The star at the centre of the Red Rectangle began its life as a star similar to our Sun. It is now nearing the end of its lifetime, and is in the process of ejecting its outer layers to produce the visible nebula. The shedding of the outer layers began about 14 000 years ago, and in a few thousand years, the star will have become smaller and hotter, releasing a flood of ultraviolet light into the surrounding nebula. When this occurs the gas in the nebula will begin to fluoresce, producing a 'planetary nebula'. At the present time, however, the star is still so cool that atoms in the nebula do not glow and the surrounding dust particles are only visible as they reflect light from the central star. Exactly which molecules in the dust cloud are responsible for the striking red colour of the Rectangle is not yet clear, but it is likely that they are some kind of hydrocarbon formed in the cool outflows from the central star. Another remarkable feature of the Red Rectangle, visible only with the superb resolution of the Hubble telescope, is the dark band passing across the central star. This is the shadow of a dense disc of dust that surrounds the star and obscures it from direct view. The light we see streams out along the axis of the disc, and is scattered towards us by dust particles. Astronomers have found that the central star is actually a close pair of stars orbiting each other with a period of about 10.5 months. Interactions between these stars have probably caused the ejection of the thick dust disc that obscures our view of the binary. The disc then funnels subsequent dust and gas outflows out along its axis, forming the bizarre bi-conical structure we see as the rung of the Red Rectangle. The reasons for these fresh periodic ejections of more gas and dust remain unknown. The Red Rectangle was first discovered during a rocket flight in the early 1970s, in which astronomers were searching for strong sources of infrared radiation. This infrared source lies about 2300 light-years from Earth in the direction of the constellation Monoceros. Stars surrounded by clouds of dust are often strong infrared sources because the dust is heated by the starlight and then re-radiates long-wavelength red light. Studies of HD 44179 with ground-based telescopes revealed a rectangular shape in the dust surrounding the star at the centre, leading to the name 'Red Rectangle', coined in 1973 by astronomers Martin Cohen and Mike Merrill. This image was made from observations taken on 17-18 March 1999 with Hubble’s Wide Field Planetary Camera 2.

The Infrared Reflection Nebula Around the Protostellar System in S140

NASA Technical Reports Server (NTRS)

Harker, D.; Bregman, J.; Tielens, A. G. G. M.; Temi, P.; Rank, D.; Morrison, David (Technical Monitor)

1994-01-01

We have studied the protostellar system in S140 at 2.2, 3.1 and 3.45 microns using a 128x128 InSb array at the Lick Observatory 3m telescope. Besides the protostellar sources, the data reveal a bright infrared reflection nebula. We have developed a simple model of this region and derived the physical conditions. IRSI is surrounded by a dense dusty disk viewed almost edge-on. Photons leaking out through the poles illuminate almost directly north and south the inner edge of a surrounding shell of molecular gas, Analysis of the observed colors and intensities of the NIR light, using Mie scattering theory, reveal that the dust grains in the molecular cloud are somewhat larger than in the general diffuse interstellar medium. Moreover, the incident light has a "cool" color temperature, approximately equals 800K, and likely originates from a dust photosphere close to the protostar. Finally, we find little H2O ice associated with the dusty disk around IRSI. Most of the 3.1 micron ice extinction arises instead from cool intervening molecular cloud material. We have compared our infrared dust observations with millimeter and radio observations of molecular gas associated with this region. The large scale structure observable in the molecular gas is indicative of the interaction between the protostellar wind and the surrounding molecular cloud rather than the geometry of the protostellar disk. We conclude that S140 is a young blister formed by this outflow on the side of a molecular cloud and viewed edge-on.

The PAH Emission Characteristics of the Reflection Nebula NGC 2023

NASA Astrophysics Data System (ADS)

Peeters, Els; Bauschlicher, Charles W., Jr.; Allamandola, Louis J.; Tielens, Alexander G. G. M.; Ricca, Alessandra; Wolfire, Mark G.

2017-02-01

We present 5-20 μm spectral maps of the reflection nebula NGC 2023 obtained with the Infrared Spectrograph SL and SH modes on board the Spitzer Space Telescope, which reveal emission from polycyclic aromatic hydrocarbons (PAHs), C60, and H2 superposed on a dust continuum. We show that several PAH emission bands correlate with each other and exhibit distinct spatial distributions that reveal a spatial sequence with distance from the illuminating star. We explore the distinct morphology of the 6.2, 7.7, and 8.6 μm PAH bands and find that at least two spatially distinct components contribute to the 7-9 μm PAH emission in NGC 2023. We report that the PAH features behave independently of the underlying plateaus. We present spectra of compact, oval PAHs ranging in size from C66 to C210, determined computationally using density functional theory, and we investigate trends in the band positions and relative intensities as a function of PAH size, charge, and geometry. Based on the NASA Ames PAH database, we discuss the 7-9 μm components in terms of band assignments and relative intensities. We assign the plateau emission to very small grains with possible contributions from PAH clusters and identify components in the 7-9 μm emission that likely originate in these structures. Based on the assignments and the observed spatial sequence, we discuss the photochemical evolution of the interstellar PAH family as the PAHs are more and more exposed to the radiation field of the central star in the evaporative flows associated with the Photo-Dissociation Regions in NGC 2023.

Turbulent Concentration of MM-Size Particles in the Protoplanetary Nebula: Scaled-Dependent Multiplier Functions

NASA Technical Reports Server (NTRS)

Cuzzi, Jeffrey N.; Hartlep, Thomas; Weston, B.; Estremera, Shariff Kareem

2014-01-01

The initial accretion of primitive bodies (asteroids and TNOs) from freely-floating nebula particles remains problematic. Here we focus on the asteroids where constituent particle (read "chondrule") sizes are observationally known; similar arguments will hold for TNOs, but the constituent particles in those regions will be smaller, or will be fluffy aggregates, and are unobserved. Traditional growth-bysticking models encounter a formidable "meter-size barrier" [1] (or even a mm-cm-size barrier [2]) in turbulent nebulae, while nonturbulent nebulae form large asteroids too quickly to explain long spreads in formation times, or the dearth of melted asteroids [3]. Even if growth by sticking could somehow breach the meter size barrier, other obstacles are encountered through the 1-10km size range [4]. Another clue regarding planetesimal formation is an apparent 100km diameter peak in the pre-depletion, pre-erosion mass distribution of asteroids [5]; scenarios leading directly from independent nebula particulates to this size, which avoid the problematic m-km size range, could be called "leapfrog" scenarios [6-8]. The leapfrog scenario we have studied in detail involves formation of dense clumps of aerodynamically selected, typically mm-size particles in turbulence, which can under certain conditions shrink inexorably on 100-1000 orbit timescales and form 10-100km diameter sandpile planetesimals. The typical sizes of planetesimals and the rate of their formation [7,8] are determined by a statistical model with properties inferred from large numerical simulations of turbulence [9]. Nebula turbulence can be described by its Reynolds number Re = L/eta sup(4/3), where L = ETA alpha sup (1/2) the largest eddy scale, H is the nebula gas vertical scale height, and a the nebula turbulent viscosity parameter, and ? is the Kolmogorov or smallest scale in turbulence (typically about 1km), with eddy turnover time t?. In the nebula, Re is far larger than any numerical simulation can handle, so some physical model is needed to extend the results of numerical simulations to nebula conditions.

On the X-ray temperature of hot gas in diffuse nebulae

NASA Astrophysics Data System (ADS)

Toalá, J. A.; Arthur, S. J.

2018-05-01

X-ray emitting diffuse nebulae around hot stars are observed to have soft-band temperatures in the narrow range [1-3]× 106 K, independent of the stellar wind parameters and the evolutionary stage of the central star. We discuss the origin of this X-ray temperature for planetary nebulae (PNe), Wolf-Rayet nebulae (WR) and interstellar wind bubbles around hot young stars in our Galaxy and the Magellanic Clouds. We calculate the differential emission measure (DEM) distributions as a function of temperature from previously published simulations and combine these with the X-ray emission coefficient for the 0.3-2.0 keV band to estimate the X-ray temperatures. We find that all simulated nebulae have DEM distributions with steep negative slopes, which is due to turbulent mixing at the interface between the hot shocked stellar wind and the warm photoionized gas. Sharply peaked emission coefficients act as temperature filters and emphasize the contribution of gas with temperatures close to the peak position, which coincides with the observed X-ray temperatures for the chemical abundance sets we consider. Higher metallicity nebulae have lower temperature and higher luminosity X-ray emission. We show that the second temperature component found from spectral fitting to X-ray observations of WR nebulae is due to a significant contribution from the hot shocked stellar wind, while the lower temperature principal component is dominated by nebular gas. We suggest that turbulent mixing layers are the origin of the soft X-ray emission in the majority of diffuse nebulae.

On the X-ray temperature of hot gas in diffuse nebulae

NASA Astrophysics Data System (ADS)

Toalá, J. A.; Arthur, S. J.

2018-07-01

X-ray-emitting diffuse nebulae around hot stars are observed to have soft-band temperatures in the narrow range [1-3] × 106K, independent of the stellar wind parameters and the evolutionary stage of the central star. We discuss the origin of this X-ray temperature for planetary nebulae, Wolf-Rayet (WR) nebulae, and interstellar wind bubbles around hot young stars in our Galaxy and the Magellanic Clouds. We calculate the differential emission measure (DEM) distributions as a function of temperature from previously published simulations and combine these with the X-ray emission coefficient for the 0.3-2.0 keV band to estimate the X-ray temperatures. We find that all simulated nebulae have DEM distributions with steep negative slopes, which is due to turbulent mixing at the interface between the hot shocked stellar wind and the warm photoionized gas. Sharply peaked emission coefficients act as temperature filters and emphasize the contribution of gas with temperatures close to the peak position, which coincides with the observed X-ray temperatures for the chemical abundance sets we consider. Higher metallicity nebulae have lower temperature and higher luminosity X-ray emission. We show that the second temperature component found from spectral fitting to X-ray observations of WR nebulae is due to a significant contribution from the hot shocked stellar wind, while the lower temperature principal component is dominated by nebular gas. We suggest that turbulent mixing layers are the origin of the soft X-ray emission in the majority of diffuse nebulae.

Facilitating NASA Earth Science Data Processing Using Nebula Cloud Computing

NASA Astrophysics Data System (ADS)

Chen, A.; Pham, L.; Kempler, S.; Theobald, M.; Esfandiari, A.; Campino, J.; Vollmer, B.; Lynnes, C.

2011-12-01

Cloud Computing technology has been used to offer high-performance and low-cost computing and storage resources for both scientific problems and business services. Several cloud computing services have been implemented in the commercial arena, e.g. Amazon's EC2 & S3, Microsoft's Azure, and Google App Engine. There are also some research and application programs being launched in academia and governments to utilize Cloud Computing. NASA launched the Nebula Cloud Computing platform in 2008, which is an Infrastructure as a Service (IaaS) to deliver on-demand distributed virtual computers. Nebula users can receive required computing resources as a fully outsourced service. NASA Goddard Earth Science Data and Information Service Center (GES DISC) migrated several GES DISC's applications to the Nebula as a proof of concept, including: a) The Simple, Scalable, Script-based Science Processor for Measurements (S4PM) for processing scientific data; b) the Atmospheric Infrared Sounder (AIRS) data process workflow for processing AIRS raw data; and c) the GES-DISC Interactive Online Visualization ANd aNalysis Infrastructure (GIOVANNI) for online access to, analysis, and visualization of Earth science data. This work aims to evaluate the practicability and adaptability of the Nebula. The initial work focused on the AIRS data process workflow to evaluate the Nebula. The AIRS data process workflow consists of a series of algorithms being used to process raw AIRS level 0 data and output AIRS level 2 geophysical retrievals. Migrating the entire workflow to the Nebula platform is challenging, but practicable. After installing several supporting libraries and the processing code itself, the workflow is able to process AIRS data in a similar fashion to its current (non-cloud) configuration. We compared the performance of processing 2 days of AIRS level 0 data through level 2 using a Nebula virtual computer and a local Linux computer. The result shows that Nebula has significantly better performance than the local machine. Much of the difference was due to newer equipment in the Nebula than the legacy computer, which is suggestive of a potential economic advantage beyond elastic power, i.e., access to up-to-date hardware vs. legacy hardware that must be maintained past its prime to amortize the cost. In addition to a trade study of advantages and challenges of porting complex processing to the cloud, a tutorial was developed to enable further progress in utilizing the Nebula for Earth Science applications and understanding better the potential for Cloud Computing in further data- and computing-intensive Earth Science research. In particular, highly bursty computing such as that experienced in the user-demand-driven Giovanni system may become more tractable in a Cloud environment. Our future work will continue to focus on migrating more GES DISC's applications/instances, e.g. Giovanni instances, to the Nebula platform and making matured migrated applications to be in operation on the Nebula.

Formation environment of cometary nuclei in the primordial solar nebula

NASA Astrophysics Data System (ADS)

Yamamoto, T.

1985-01-01

The formation environment of comets in the primordial solar nebula is investigated from the point of view of the chemical composition of the ices of cometary nuclei. A sublimation sequence for various species of possible constituents of the nuclear ice, which would have condensed on the grain surface in the parent interstellar cloud was obtained by calculating the temperature of grains in the solar nebula. On this basis, an allowed range of the nebular temperature in the formation region of cometary nuclei is obtained from a condition for retention of the ices of the nuclear composition. Combining this result with models of the solar nebula, the region for the formation of cometary nuclei in the solar nebula is discussed. It is shown that cometary nuclei formed at least beyond the region between the formation regions of Saturn and Uranus. Finally, an upper limit is estimated for the grain temperature in the region of comet formation at an earlier stage of the solar nebula. The grain temperature is shown to be less than 60 K at this stage.

Solar Nebula Magnetohydrodynamic Dynamos: Kinematic Theory, Dynamical Constraints, and Magnetic Transport of Angular Momentum

NASA Technical Reports Server (NTRS)

Stepinski, Tomasz F.; Reyes-Ruiz, Mauricio; Vanhala, Harri A. T.

1993-01-01

A hydromagnetic dynamo provides the best mechanism for contemporaneously producing magnetic fields in a turbulent solar nebula. We investigate the solar nebula in the framework of a steady-state accretion disk model and establish the criteria for a viable nebular dynamo. We have found that typically a magnetic gap exists in the nebula, the region where the degree of ionization is too small for the magnetic field to couple to the gas. The location and width of this gap depend on the particular model; the supposition is that gaps cover different parts of the nebula at different evolutionary stages. We have found, from several dynamical constraints, that the generated magnetic field is likely to saturate at a strength equal to equipartition with the kinetic energy of turbulence. Maxwell stress arising from a large-scale magnetic field may significantly influence nebular structure, and Maxwell stress due to small-scale fields can actually dominate other stresses in the inner parts of the nebula. We also argue that the bulk of nebular gas, within the scale height from the midplane, is stable against Balbus-Hawley instability.

7 CFR 1280.607 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2010 CFR

2010-01-01

... LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280... referred to as “CED,” means the person employed by the FSA County Committee to execute the policies of the...

7 CFR 1280.607 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2013 CFR

2013-01-01

... LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280... referred to as “CED,” means the person employed by the FSA County Committee to execute the policies of the...

7 CFR 1280.607 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2012 CFR

2012-01-01

... LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280... referred to as “CED,” means the person employed by the FSA County Committee to execute the policies of the...

7 CFR 1280.607 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2014 CFR

2014-01-01

... LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280... referred to as “CED,” means the person employed by the FSA County Committee to execute the policies of the...

7 CFR 1280.607 - Farm Service Agency County Executive Director.

Code of Federal Regulations, 2011 CFR

2011-01-01

... LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280... referred to as “CED,” means the person employed by the FSA County Committee to execute the policies of the...

Models, Measurements, and Local Decisions: Assessing and ...

EPA Pesticide Factsheets

This presentation includes a combination of modeling and measurement results to characterize near-source air quality in Newark, New Jersey with consideration of how this information could be used to inform decision making to reduce risk of health impacts. Decisions could include either exposure or emissions reduction, and a host of stakeholders, including residents, academics, NGOs, local and federal agencies. This presentation includes results from the C-PORT modeling system, and from a citizen science project from the local area. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma.

PubMed

Arshad, Azeem; Yang, Bin; Bienemann, Alison S; Barua, Neil U; Wyatt, Marcella J; Woolley, Max; Johnson, Dave E; Edler, Karen J; Gill, Steven S

2015-01-01

We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires intermittent infusions due to rapid clearance of carboplatin from the brain. In this study, carboplatin was encapsulated in lactic acid-glycolic acid copolymer (PLGA) to develop a novel drug delivery system. Neuronal and tumour cytotoxicity were assessed in primary neuronal and glioblastoma cell cultures. Distribution, tissue clearance and toxicity of carboplatin nanoparticles following CED was assessed in rat and porcine models. Carboplatin nanoparticles conferred greater tumour cytotoxicity, reduced neuronal toxicity and prolonged tissue half-life. In conclusion, this drug delivery system has the potential to improve the prognosis for patients with glioblastomas.

Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma

PubMed Central

Arshad, Azeem; Yang, Bin; Bienemann, Alison S.; Barua, Neil U.; Wyatt, Marcella J.; Woolley, Max; Johnson, Dave E.; Edler, Karen J.; Gill, Steven S.

2015-01-01

We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires intermittent infusions due to rapid clearance of carboplatin from the brain. In this study, carboplatin was encapsulated in lactic acid-glycolic acid copolymer (PLGA) to develop a novel drug delivery system. Neuronal and tumour cytotoxicity were assessed in primary neuronal and glioblastoma cell cultures. Distribution, tissue clearance and toxicity of carboplatin nanoparticles following CED was assessed in rat and porcine models. Carboplatin nanoparticles conferred greater tumour cytotoxicity, reduced neuronal toxicity and prolonged tissue half-life. In conclusion, this drug delivery system has the potential to improve the prognosis for patients with glioblastomas. PMID:26186224

WRF/CMAQ AQMEII3 Simulations of US Regional-Scale ...

EPA Pesticide Factsheets

Chemical boundary conditions are a key input to regional-scale photochemical models. In this study, performed during the third phase of the Air Quality Model Evaluation International Initiative (AQMEII3), we perform annual simulations over North America with chemical boundary conditions prepared from four different global models. Results indicate that the impacts of different boundary conditions are significant for ozone throughout the year and most pronounced outside the summer season. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

Current status of intratumoral therapy for glioblastoma.

PubMed

Mehta, Ankit I; Linninger, Andreas; Lesniak, Maciej S; Engelhard, Herbert H

2015-10-01

With emerging drug delivery technologies becoming accessible, more options are expected to become available to patients with glioblastoma (GBM) in the near future. It is important for clinicians to be familiar with the underlying mechanisms and limitations of intratumoral drug delivery, and direction of recent research efforts. Tumor-adjacent brain is an extremely complex living matrix that creates challenges with normal tissue intertwining with tumor cells. For convection-enhanced delivery (CED), the role of tissue anisotropy for better predicting the biodistribution of the infusate has recently been studied. Computational predictive methods are now available to better plan CED therapy. Catheter design and placement—in addition to the agent being used—are critical components of any protocol. This paper overviews intratumoral therapies for GBM, highlighting key anatomic and physiologic perspectives, selected agents (especially immunotoxins), and some new developments such as the description of the glymphatic system.

[Comparative study of three Western models of deontological codes for dentists].

PubMed

Macpherson Mayol, Ignacio; Roqué Sánchez, María Victoria; Gonzalvo-Cirac, Margarita; de Ribot, Eduard

2013-01-01

We performed a comparative analysis of the codes of ethics of three official organizations in Dentistry professional ethics: Code of Ethics for Dentists in the European Union, drawn up by the Council of European Dentists (CED); Código Español de Ética y Deontología Dental, published by the Consejo General de Colegios de Odontólogos y Estomatólogos de España (CGCOE); and Principles of Ethics and Code of Professional Conduct, of the American Dental Association (ADA). The analysis of the structure of the codes allows the discovery of different approaches governing professional ethics according to the ethical and legislative tradition from which they derive. While there are common elements inherent in Western culture, there are nuances in the grounds, the layout and wording of articles that allows to deduce the ethical foundations that underlie each code, and reflects the real problems encountered by dentists in the practice of their profession.

Nucleosynthesis of intermediate mass stars: inferences from the observed abundances in photoionized nebulae of the Local Group

NASA Astrophysics Data System (ADS)

Maciel, W. J.; Costa, R. D. D.; Cavichia, O.

2018-01-01

Photoionized nebulae, comprising HII regions and planetary nebulae, are excellent laboratories to investigate the nucleosynthesis and chemical evolution of several elements in the Galaxy and other galaxies of the Local Group. Our purpose in this investigation is threefold: (i) to compare the abundances of HII regions and planetary nebulae in each system in order to investigate the differences derived from the age and origin of these objects, (ii) to compare the chemical evolution in different systems, such as the Milky Way, the Magellanic Clouds, and other galaxies of the Local Group, and (iii) to investigate to what extent the nucleosynthesis contributions from the progenitor stars affect the observed abundances in planetary nebulae, especially for oxygen and neon, which places constraints on the amount of these elements that can be produced by intermediate mass stars.

The ALMA early science view of FUor/EXor objects - IV. Misaligned outflows in the complex star-forming environment of V1647 Ori and McNeil's Nebula

NASA Astrophysics Data System (ADS)

Principe, David A.; Cieza, Lucas; Hales, Antonio; Zurlo, Alice; Williams, Jonathan; Ruíz-Rodríguez, Dary; Canovas, Hector; Casassus, Simon; Mužić, Koraljka; Perez, Sebastian; Tobin, John J.; Zhu, Zhaohuan

2018-01-01

We present Atacama Large Millimeter/sub-millimeter Array (ALMA) observations of the star-forming environment surrounding V1647 Ori, an outbursting FUor/EXor pre-main sequence star. Dust continuum and the (J = 2 - 1) 12CO, 13CO, C18O molecular emission lines were observed to characterize the V1647 Ori circumstellar disc and any large scale molecular features present. We detect continuum emission from the circumstellar disc and determine a radius r = 40 au, inclination i = 17°+6-9 and total disc mass of Mdisc of ∼0.1 M⊙. We do not identify any disc structures associated with nearby companions, massive planets or fragmentation. The molecular cloud environment surrounding V1647 Ori is both structured and complex. We confirm the presence of an excavated cavity north of V1647 Ori and have identified dense material at the base of the optical reflection nebula (McNeil's Nebula) that is actively shaping its surrounding environment. Two distinct outflows have been detected with dynamical ages of ∼11 700 and 17 200 yr. These outflows are misaligned suggesting disc precession over ∼5500 yr as a result of anisotropic accretion events is responsible. The collimated outflows exhibit velocities of ∼2 km s-1, similar in velocity to that of other FUor objects presented in this series, but significantly slower than previous observations and model predictions. The V1647 Ori system is seemingly connected by an 'arm' of material to a large unresolved structure located ∼20 arcsec to the west. The complex environment surrounding V1647 Ori suggests it is in the early stages of star formation, which may relate to its classification as both a FUor and EXor type object.

The Diary of Frances Jacobs: Astronomical Observations by a 19th-century Oregon Woman

NASA Astrophysics Data System (ADS)

McGown, R. D.

2002-12-01

This abstract summarizes my research, transcription and editing of Francis Jacob's 170-page handwritten astronomical diary. This diary is a unique example of a time in early Portland history, illustrating the mind of a young woman who was interested in science and astronomy. Reflected in her diary are the discoveries and mention of leading astronomers of the day like Emerson Bernard and Edward Pickering. Francis Jacobs lived in an era of the great refractors For example, ``The Leviathan," built by Lord Rosse in Ireland was completed in 1847. In this 72-inch telescope, stars of 18th magnitude could be seen. The first spiral nebulae to be revealed was M51 - known today as the Whirlpool Galaxy. The Earl was the first to suggest that these spirals could actually be rotating masses of stars. At the turn of the century, study of observational astronomy was rooted in naked eye observing, study of binary stars and nebula. This was a time when women were becoming interested in the sciences and had begun to play an important role in science and astronomy. It was an incredible inspiration for other women across the country to hear what was happening on the astronomical frontiers at Harvard. Some constellation asterisms used in Francis Jacob's diary were different than they are today. One asterism in particular, the Egyptian Cross, is relatively unknown now. The summer triangle and winter circle asterisms were used in her notes and obviously popular in her era, as today. Her written comments included some Messier catalogue numbers and in some case written on her sketches and diagrams nicknames, such as the 'Dumbbell' nebula. She also referred to M99 as `St. Katherine's Wheel', a nickname that is not in common use today.

The near-infrared structure and spectra of the bipolar nebulae M2-9 and AFGL 2688: The role of ultraviolet pumping and shocks in molecular hydrogen excitation

NASA Technical Reports Server (NTRS)

Hora, Joseph L.; Latter, William B.

1994-01-01

High-resolution near-infrared images and moderate resolution spectra were obtained of the bipolar nebulae M2-9 and AFGL 2688. The ability to spatially and spectrally resolve the various components of the nebulae has proved to be important in determining their physical structure and characteristics. In M2-9, the lobes are found to have a double-shell structure. The inner shell is dominated by emission from hydrogen recombination lines, and the outer shell is primarily emission from H2 lines in teh 2-2.5 micron region. Analysis of H2 line ratios indicates that the H2 emission is radiatively excited. A well-resolved photodissociation region is observed in the lobes. The spectrum of the central source is dominated by H recombination lines and a strong continuum rising toward longer wavelengths consistent with a T = 795 K blackbody. Also present are lines of He I and Fe II. In contrast, the N knot and E lobe of M2-9 show little continuum emission. The N knot spectrum consists of lines of (Fe II) and hydrogen recombination lines. In AGFL 2688, the emission from the bright lobes is mainly continuum reflected from the central star. Several molecular features from C2 and CN are present. In the extreme end of the N lobe and in the E equatorial region, the emission is dominated by lines of H2 in the 2-2.5 region. The observed H2 line ratios indicate that the emission is collisionally excited, with an excitation temperature T(sub ex) approixmately = 1600 +/- 100 K.

The population of TeV pulsar wind nebulae in the H.E.S.S. Galactic Plane Survey

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Bulik, T.; Capasso, M.; Carr, J.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Couturier, C.; Cui, Y.; Davids, I. D.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dubus, G.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hadasch, D.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kerszberg, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; de Oña Wilhelmi, E.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tuffs, R.; Uchiyama, Y.; Valerius, K.; van der Walt, D. J.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.

2018-04-01

The nine-year H.E.S.S. Galactic Plane Survey (HGPS) has yielded the most uniform observation scan of the inner Milky Way in the TeV gamma-ray band to date. The sky maps and source catalogue of the HGPS allow for a systematic study of the population of TeV pulsar wind nebulae found throughout the last decade. To investigate the nature and evolution of pulsar wind nebulae, for the first time we also present several upper limits for regions around pulsars without a detected TeV wind nebula. Our data exhibit a correlation of TeV surface brightness with pulsar spin-down power Ė. This seems to be caused both by an increase of extension with decreasing Ė, and hence with time, compatible with a power law RPWN(Ė) Ė-0.65±0.20, and by a mild decrease of TeV gamma-ray luminosity with decreasing Ė, compatible with L1-10 TeV Ė0.59±0.21. We also find that the offsets of pulsars with respect to the wind nebula centre with ages around 10 kyr are frequently larger than can be plausibly explained by pulsar proper motion and could be due to an asymmetric environment. In the present data, it seems that a large pulsar offset is correlated with a high apparent TeV efficiency L1-10 TeV/Ė. In addition to 14 HGPS sources considered firmly identified pulsar wind nebulae and 5 additional pulsar wind nebulae taken from literature, we find 10 HGPS sources that are likely TeV pulsar wind nebula candidates. Using a model that subsumes the present common understanding of the very high-energy radiative evolution of pulsar wind nebulae, we find that the trends and variations of the TeV observables and limits can be reproduced to a good level, drawing a consistent picture of present-day TeV data and theory.

Interstellar gas in the Gum Nebula

NASA Technical Reports Server (NTRS)

Wallerstein, G.; Jenkins, E. B.; Silk, J.

1980-01-01

A survey of the interstellar gas near the Gum Nebula by optical observation of 67 stars at Ca II, 42 stars at Na I, and 14 stars in the UV with the Copernicus satellite provided radial velocities and column densities for all resolved absorption components. Velocity dispersions for gas in the Gum Nebula are not significantly larger than in the general interstellar medium; the ionization structure is predominantly that of an H II region with moderately high ionization. Denser, more highly ionized clouds are concentrated toward the Gum Nebula; these clouds do not show the anomalously high ionization observed in the Vela remnant clouds.

Disk Chemistry and Cometary Composition

NASA Astrophysics Data System (ADS)

Markwick, A. J.; Charnley, S. B.

2003-05-01

We will describe current chemical modelling of disks similar to the protosolar nebula. Calculations are being undertaken to determine the spatial and temporal chemistry of the gas and dust within the 5-40AU comet-forming region of the nebula. These theoretical studies aim to determine the contribution of pristine and partially-processed interstellar material from the cool outer nebula, as compared to that obtained from outward radial mixing of matter from the hot inner nebula. Reference Molecular distributions in the inner regions of protostellar disks, Markwick, A. J., Ilgner, M., Millar, T. J., Henning, Th. (2002), Astron. Astrophys., 385, 632.

Disk Chemistry and Cometary Composition

NASA Astrophysics Data System (ADS)

Markwick, A. J.; Charnley, S. B.

2005-01-01

We will describe current chemical modelling of disks similar to the protosolar nebula. Calculations are being undertaken to determine the spatial and temporal chemistry of the gas and dust within the 5-40AU comet-forming region of the nebula. These theoretical studies aim to determine the contribution of pristine and partially-processed interstellar material from the cool outer nebula as compared to that obtained from outward radial mixing of matter from the hot inner nebula. Reference Molecular distributions in the inner regions of protostellar disks Markwick A. J. Ilgner M. Millar T. J. Henning Th. (2002) Astron. Astrophys. 385 632

The Trifid Nebula

NASA Technical Reports Server (NTRS)

1997-01-01

This NASA Hubble Space Telescope (HST) image of the Trifid Nebula reveals a stellar nursery being torn apart by a nearby massive star. Embryonic stars are forming within an ill-fated cloud of dust and gas, which is destined to be eaten away by the glare from the massive neighbor. The cloud is about 8 light years away from the nebula' s central star. This stellar activity is a beautiful example of how the life cycle of stars like our Sun is intimately cornected with their more powerful siblings. Residing in the constellation Sagittarius, the Trifid Nebula is about 9,000 light years from Earth.

Detection of molecular hydrogen emission from five planetary nebulae

NASA Technical Reports Server (NTRS)

Beckwith, S.; Gatley, I.; Persson, S. E.

1978-01-01

The v = 1 to 0 S(1) line of molecular hydrogen has been detected in five planetary nebulae. They are the Ring Nebula (M57, NGC 6720), BD+30 deg 3639, Hb 12, CRL 618, and CRL 2688. A region in the northeast of the Ring Nebula has been mapped in both the v = 1 to 0 S(1) molecular hydrogen line and the Brackett gamma line of atomic hydrogen. The H2 emission is not spatially correlated with the B-gamma, but is correlated with the (OI) emission as determined from interference filter photographs.

Refractory Inclusion Size Distribution and Fabric Measured in a Large Slab of the Allende CV3 Chondrite

NASA Technical Reports Server (NTRS)

Srinivasan, P.; Simon, Justin I.; Cuzzi, J. N.

2013-01-01

Aggregate textures of chondrites reflect accretion of early-formed particles in the solar nebula. Explanations for the size and density variations of particle populations found among chondrites are debated. Differences could have risen out of formation in different locations in the nebula, and/or they could have been caused by a sorting process [1]. Many ideas on the cause of chondrule sorting have been proposed; some including sorting by mass [2,3], by X-winds [4], turbulent concentration [5], and by photophoresis [6]. However, few similar studies have been conducted for Ca-, Al-rich inclusions (CAIs). These particles are known to have formed early, and their distribution could attest to the early stages of Solar System (ESS) history. Unfortunately, CAIs are not as common in chondrites as chondrules are, reducing the usefulness of studies restricted to a few thin sections. Furthermore, the largest sizes of CAIs are generally much larger than chondrules, and therefore rarely present in most studied chondrite thin sections. This study attempts to perform a more representative sampling of the CAI population in the Allende chondrite by investigating a two decimeter-sized slab.

Featured Image: A Detailed Look at the Crab Nebula

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-07-01

Planning on watching fireworks tomorrow? Heres an astronomical firework to help you start the celebrations! A new study has stunningly detailed the Crab Nebula (click for a closer look), a nebula 6,500 light-years away thought to have been formedby a supernova explosion and the subsequent ultrarelativistic wind emitted by the pulsar at its heart. Led by Gloria Dubner (University of Buenos Aires), the authors of this study obtained new observations of the Crab Nebula from five different telescopes. They compiled these observations to compare the details of the nebulas structure across different wavelengths, which allowedthem to learnabout the sources of various features within the nebula. In the images above, thetop left shows the 3 GHz data from the Very Large Array (radio). Moving clockise, the radio data (shown in red) is composited with: infrared data from Spitzer Space Telescope, optical continuum from Hubble Space Telescope, 500-nm optical datafrom Hubble, and ultraviolet data from XMM-Newton. The final two images are of the nebula center, and they are composites of the radio imagewith X-ray data from Chandra and near-infrared data from Hubble. To read more about what Dubner and collaborators learned (and to see more spectacular images!), check out the paper below.CitationG. Dubner et al 2017 ApJ 840 82. doi:10.3847/1538-4357/aa6983

Gonadal and Sexual Dysfunction in Childhood Cancer Survivors.

PubMed

Yoon, Ju Young; Park, Hyeon Jin; Ju, Hee Young; Yoon, Jong Hyung; Chung, Jin Soo; Hwang, Sang Hyun; Lee, Dong Ock; Shim, Hye Young; Park, Byung-Kiu

2017-10-01

Few studies have addressed gonadal and sexual dysfunctions in childhood cancer survivors. We evaluated the prevalence rates and risk factors for gonadal failure among adolescent/young adult childhood cancer survivors and their sexual function. Subjects were childhood cancer survivors aged 15-29 years who had completed therapy more than 2 years ago. Demographic and medical characteristics were obtained from the patients' medical records. In addition, hormonal evaluation and semen analysis were performed and sexual function was evaluated via questionnaire. The study included 105 survivors (57 males, 48 females), of which 61 were adults (age > 19 years) and 44 were adolescents. In both males and females, the proportion of survivors with low sex hormone levels did not differ among age groups or follow-up period. Thirteen female subjects (27.1%) needed sex hormone replacement, while five males subjects (8.8%) were suspected of having hypogonadism, but none were receiving sex hormone replacement. Of 27 semen samples, 14 showed azospermia or oligospermia. The proportion of normospermia was lower in the high cyclophosphamide equivalent dose (CED) group (CED ≥ 8,000 mg/m2) than the low CED group (27.3% vs. 62.5%, p=0.047). Among adults, none were married and only 10 men (35.7%) and eight women (34.3%) were in a romantic relationship. Though a significant proportion (12.0% of males and 5.3% of females) of adolescent survivors had experienced sexual activity, 13.6% had not experienced sex education. The childhood cancer survivors in this study showed a high prevalence of gonadal/sexual dysfunction; accordingly, proper strategies are needed to manage these complications.

Dynamic Contrast-Enhanced MRI of Gd-albumin Delivery to the Rat Hippocampus In Vivo by Convection-Enhanced Delivery

PubMed Central

Kim, Jung Hwan; Astary, Garrett W.; Nobrega, Tatiana L.; Kantorovich, Svetlana; Carney, Paul R.; Mareci, Thomas H.; Sarntinoranont, Malisa

2013-01-01

Convection enhanced delivery (CED) shows promise in treating neurological diseases due to its ability to circumvent the blood-brain barrier (BBB) and deliver therapeutics directly to the parenchyma of the central nervous system (CNS). Such a drug delivery method may be useful in treating CNS disorders involving the hippocampus such temporal lobe epilepsy and gliomas; however, the influence of anatomical structures on infusate distribution is not fully understood. As a surrogate for therapeutic agents, we used gadolinium-labeled-albumin (Gd-albumin) tagged with Evans blue dye to observe the time dependence of CED infusate distributions into the rat dorsal and ventral hippocampus in vivo with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). For finer anatomical detail, final distribution volumes (Vd) of the infusate were observed with high-resolution T1-weighted MR imaging and light microscopy of fixed brain sections. Dynamic images demonstrated that Gd-albumin preferentially distributed within the hippocampus along neuroanatomical structures with less fluid resistance and less penetration was observed in dense cell layers. Furthermore, significant leakage into adjacent cerebrospinal fluid (CSF) spaces such as the hippocampal fissure, velum interpositum and midbrain cistern occurred toward the end of infusion. Vd increased linearly with infusion volume (Vi) at a mean Vd/Vi ratio of 5.51 ± 0.55 for the dorsal hippocampus infusion and 5.30 ± 0.83 for the ventral hippocampus infusion. This study demonstrated the significant effects of tissue structure and CSF space boundaries on infusate distribution during CED. PMID:22687936

Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.

PubMed

Stiles, David K; Zhang, Zhiming; Ge, Pei; Nelson, Brian; Grondin, Richard; Ai, Yi; Hardy, Peter; Nelson, Peter T; Guzaev, Andrei P; Butt, Mark T; Charisse, Klaus; Kosovrasti, Verbena; Tchangov, Lubomir; Meys, Michael; Maier, Martin; Nechev, Lubomir; Manoharan, Muthiah; Kaemmerer, William F; Gwost, Douglas; Stewart, Gregory R; Gash, Don M; Sah, Dinah W Y

2012-01-01

Huntington's disease is an autosomal dominant neurodegenerative disease caused by a toxic gain of function mutation in the huntingtin gene (Htt). Silencing of Htt with RNA interference using direct CNS delivery in rodent models of Huntington's disease has been shown to reduce pathology and promote neuronal recovery. A key translational step for this approach is extension to the larger non-human primate brain, achieving sufficient distribution of small interfering RNA targeting Htt (siHtt) and levels of Htt suppression that may have therapeutic benefit. We evaluated the potential for convection enhanced delivery (CED) of siHtt to provide widespread and robust suppression of Htt in nonhuman primates. siHtt was infused continuously for 7 or 28 days into the nonhuman primate putamen to analyze effects of infusion rate and drug concentration on the volume of effective suppression. Distribution of radiolabeled siHtt and Htt suppression were quantified by autoradiography and PCR, respectively, in tissue punches. Histopathology was evaluated and Htt suppression was also visualized in animals treated for 28 days. Seven days of CED led to widespread distribution of siHtt and significant Htt silencing throughout the nonhuman primate striatum in an infusion rate and dose dependent manner. Htt suppression at therapeutic dose levels was well tolerated by the brain. A model developed from these results predicts that continuous CED of siHtt can achieve significant coverage of the striatum of Huntington's disease patients. These findings suggest that this approach may provide an important therapeutic strategy for treating Huntington's disease. Copyright © 2011 Elsevier Inc. All rights reserved.

Assessment of Committed Effective Dose due to consumption of Red Sea coral reef fishes collected from the local market (Sudan).

PubMed

Hassona, Rifaat K; Sam, A K; Osman, O I; Sirelkhatim, D A; LaRosa, J

2008-04-15

An assessment of Committed Effective Dose (CED) due to consumption of Red Sea fish containing (210)Po and (137)Cs was performed for 23 different marine fish samples collected from the local market at Port Sudan. The fish were classified according to their feeding habits into three categories: carnivores, herbivores, and omnivores. Measured activity concentrations of (210)Po were found in the ranges 0.25-6.42 (carnivores), 0.7-5 (omnivores) and 1.5-3.8 (herbivores) Bq/kg fresh weight. In the same study, activity concentrations of Cs-137 were determined to be in the ranges 0.1-0.46 (carnivores), 0.09-0.35 (omnivores) and 0.09-0.32 (herbivores) Bq/kg fresh weight, which were several times lower than those of (210)Po. Appropriate conversion factors were used to derive the CED, which was found to be 0.012, 0.01 and 0.01 (microSv/yr) in carnivores, omnivores and herbivores, respectively, for (137)Cs. This contributes about 0.4% of the total dose exclusively by ingestion of fish. For (210)Po, it was found to be 3.47, 4.81 and 4.14 (microSv/yr) in carnivores, omnivores and herbivores, respectively, which represents 99.6% of the total dose (exclusively by ingestion of fish). The results of CED calculations suggest that the dose received by the Sudanese population from the consumption of marine fish is rather small and that the contribution of (137)Cs is negligible compared to (210)Po.

Consumption of Caffeinated Energy Drinks Among Youth and Young Adults in Canada.

PubMed

Reid, Jessica L; McCrory, Cassondra; White, Christine M; Martineau, Chantal; Vanderkooy, Pat; Fenton, Nancy; Hammond, David

2017-03-01

The growing market for caffeinated energy drinks (CEDs) has caused concern about excessive caffeine intake and potential adverse effects, particularly among young people. The current study examined patterns of CED consumption among youth and young adults in Canada, using data from a national online survey conducted in October 2014. Data from a non-probability sample of 2040 respondents aged 12-24 from a consumer panel was weighted to national proportions; measures of CED consumption were estimated, including prevalence, excessive daily consumption, and context for use (locations and reasons). Separate logistic regression models for two outcomes, past-week consumption and "ever" exceeding two energy drinks in a day (as per common guidance), were conducted to examine associations with demographic variables (sex, age, geographic region, race/ethnicity, and language). Overall, 73.6% of respondents reported "ever" consuming energy drinks; 15.6% had done so in the past week. Any consumption of energy drinks in the past week was more prevalent among males, Aboriginal respondents (vs. white only or mixed/other), and residents of British Columbia. Among "ever-consumers," 16.0% reported ever consuming more than two energy drinks in a day. Exceeding two in a day was more prevalent among older respondents (young adults aged 18-24), aboriginal respondents (vs. white only), and British Columbia residents. While the majority of youth and young adults had consumed energy drinks, about half were "experimental" consumers (i.e., consumed ≤ 5 drinks in their lifetime). Approximately one in six consumers had exceeded the usual guidance for maximum daily consumption, potentially increasing their risk of experiencing adverse effects.

Kinematics of the Huyghenian region of the Orion Nebula.

NASA Technical Reports Server (NTRS)

Fischel, D.; Feibelman, W. A.

1973-01-01

Palomar data published by Wilson et al. (1959) on Orion Nebula wavelength 3726 and 5007 forbidden OII and OIII emission lines have been used to construct a presented pair of contour maps of isovelocities in intervals of 2.5 km/sec. The space motions of theta-1 and theta-2 Ori stars and nebula measurements are discussed.