Ecology of Canada lynx in southern boreal forests [Chapter 13

Treesearch

Keith B. Aubry; Gary M. Koehler; John R. Squires

2000-01-01

Canada lynx occur throughout boreal forests of North America, but ecological conditions in southern regions differ in many respects from those in Canada and Alaska. To evaluate the extent to which lynx ecology and population biology may differ between these regions, we review existing information from southern boreal forests and compare our findings to...

Factors Affecting School Participation in Turkey: An Analysis of Regional Differences

ERIC Educational Resources Information Center

Gumus, Sedat; Chudgar, Amita

2016-01-01

There are thousands of children who remain out of school at both primary and secondary levels in Turkey. The current disparities in access to education in Turkey are mostly driven by systematic regional differences and high gender inequalities. Although several existing studies have paid close attention to gender-based inequities in school access,…

Intercomparisons of Total Precipitable Water from Satellite and Other Long Term Data Sets

NASA Technical Reports Server (NTRS)

Chang, Fong-Chiau; Jedlovec, Gary J.; Suggs, Ronnie J.; Guillory, Anthony R.

1998-01-01

Global water vapor data sets from satellite (NVAP) and reanalysis (NCEP and DAO) are intercompared for a 5 year period (1988-1992). Global average indicates that the NCEP and DAO reanalyses are dryer than NVAP over much of the period. Spatial patterns of the NCEP/NVAP and DAO/NVAP differences show regional variations in the 60 month climatogical fields. For example, in the Eastern Pacific just south of the equator NVAP is much dryer than the NCEP and more moist than DAO. Rather large discrepancies exist in other regions as well. North Africa, Saudi Arabia, India, and Australia show that NVAP TPW values are more moist than the NCEP and DAO model analyses by 4-8 mm. In general, the NCEP and DAO exhibits a tendency to be dryer than NVAP over the tropical ocean region. Over the Americas little differences exist except over the west coast. The shapes of the differences fields over the Eastern Pacific region are significantly different between NCEP/NVAP and DAO/NVAP differences. Over South America and Central Africa, DAO TPW values are significantly higher than those of NVAP. These difference fields show monthly and seasonal variability as well. These results will be highlighted in the paper and on the poster.

An Empirical Study of the Distributional Changes in Higher Education among East, Middle and West China

ERIC Educational Resources Information Center

Jiang, Chunjiao; Li, Song

2008-01-01

Based on the quantitative research and comparative study method, this paper attempts to make a systematic study and analysis of regional differences which have existed since 1949 in higher education among East, Middle and West China. The study is intended to explore the causes, regional differences, social changes, and their co-related…

Regional differences in echocardiography provision in New Zealand--results from the 2013 SCANZ Workforce Survey.

PubMed

Buckley, Belinda A; Poppe, Katrina; Farnworth, Mark J; Whalley, Gillian

2015-01-30

Abstract Healthcare may be unevenly distributed based on geographic location. This study aimed to identify whether regional differences in echocardiography provision exist and, if so, to explore key causes. In March 2013, 18 public hospitals with a sonographer-led echocardiography service were surveyed, all of which provided data. Questions related to characteristics of the sonographer workforce, echocardiogram volumes and workflows. Information on District Health Board (DHB) population was obtained from public access websites. Multivariable linear regression was performed using the following variables: ethnicity, age, socioeconomic status, type of centre, sonographer full-time equivalent (FTE) and number/proportion of trainees to determine their potential contribution to echocardiogram volume. 1748 echocardiograms were performed per 100,000 population (mean) with significant differences seen amongst DHBs but not between tertiary surgical and regional centres (surgical median 1802, regional median 1658, p=0.18). Regional disparity in the population-based cardiac sonographer workforce size was observed and the number of scans performed per sonographer was higher in larger centres. In multivariable modelling, the DHB population-based scan volume was predicted by: socioeconomic status (top two quintiles of deprivation status increased scans by 75 per 100,000 population, p=0.02) and age (age 20 to 65 years increased scans by 131 per 100,000 population, p=0.06). Regional differences in echocardiography services in New Zealand exist as evidenced by marked regional disparity in both population-based echo volumes and cardiac sonographer workforce size.

Numerical analysis of turbulent coaxial flow with internal heat generation

NASA Technical Reports Server (NTRS)

Lin, A.; Weinstein, H.

1981-01-01

A computational method with which to obtain a physical understanding of the turbulent field of two coaxial jets entering an axisymmetric chamber is developed. Even the laminar field of this flow is quite complicated. This is due to the many different domains which exist in the field especially in the entrance region. Physically, three regions may be identified: the wall region, the initial region near the axis of symmetry and the mixing region. Advancing downstream, these regions change relative size with the ratio of the two jets' mass fluxes as the main parameter. The turbulent field of these flows is much more complicated due to the difference in the effective transport coefficients and turbulence level from region to region. However, being aware beforehand of the complications and the different regions of this field, the appropriate turbulence model and numerical scheme can be adjusted to treat the problem.

The nucleus of 19/P Borrelly as revealed by deep space 1

USGS Publications Warehouse

Buratti, B.; Hicks, M.; Soderblom, L.; Britt, D.; Boice, D.; Brown, R.; Nelson, R.; Oberst, J.; Owen, Timothy W.; Sandel, B.; Stern, S.A.; Thomas, N.; Yelle, R.

2002-01-01

The Deep Space 1 encounter with comet 19/P Borrelly offered the first close-up view of a comet unobscured by dust. The geometric albedo of the comet is 0.029±0.006 (with a size of 8.0 × 3.15 km), comparable to the low-albedo hemisphere of Iapetus, the lowest albedo C-type asteroids, and the Uranian rings. Albedo variegations on the body are substantial, far greater than on the handful of asteroids so far scrutinized by spacecraft. The Bond albedo of Borrelly is 0.009 ± 0.002, the lowest of any object in the Solar System. The physical photometric parameters of the comet are similar to asteroids, but the optically active portion of its regolith may be fluffier. Differences in macroscopic roughness exist on its surface: the older regions appear to be slightly less rough, as if low-lying regions are infilled with native dust. Regional differences in the single particle phase function exist, with small regions exhibiting almost isotropic functions.

Generation and reactivation of T-cell receptor A joining region pseudogenes in primates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thiel, C.; Lanchbury, J.S.; Otting, N.

1996-06-01

Tandemly duplicated T-cell receptor (Tcr) AJ (J{alpha}) segments contribute significantly to TCRA chain junctional region diversity in mammals. Since only limited data exists on TCRA diversity in nonhuman primates, we examined the TCRAJ regions of 37 chimpanzee and 71 rhesus macaque TCRA cDNA clones derived from inverse polymerase chain reaction on peripheral blood mononuclear cell cDNA of healthy animals. Twenty-five different TCRAJ regions were characterized in the chimpanzee and 36 in the rhesus macaque. Each bears a close structural relationship to an equivalent human TCRAJ region. Conserved amino acid motifs are shared between all three species. There are indications thatmore » differences between nonhuman primates and humans exist in the generation of TCRAJ pseudogenes. The nucleotide and amino acid sequences of the various characterized TCRAJ of each species are reported and we compare our results to the available information on human genomic sequences. Although we provide evidence of dynamic processes modifying TCRAJ segments during primate evolution, their repertoire and primary structure appears to be relatively conserved. 21 refs., 2 figs.« less

Elevation-dependent warming in global climate model simulations at high spatial resolution

NASA Astrophysics Data System (ADS)

Palazzi, Elisa; Mortarini, Luca; Terzago, Silvia; von Hardenberg, Jost

2018-06-01

The enhancement of warming rates with elevation, so-called elevation-dependent warming (EDW), is one of the regional, still not completely understood, expressions of global warming. Sentinels of climate and environmental changes, mountains have experienced more rapid and intense warming trends in the recent decades, leading to serious impacts on mountain ecosystems and downstream. In this paper we use a state-of-the-art Global Climate Model (EC-Earth) to investigate the impact of model spatial resolution on the representation of this phenomenon and to highlight possible differences in EDW and its causes in different mountain regions of the Northern Hemisphere. To this end we use EC-Earth climate simulations at five different spatial resolutions, from ˜ 125 to ˜ 16 km, to explore the existence and the driving mechanisms of EDW in the Colorado Rocky Mountains, the Greater Alpine Region and the Tibetan Plateau-Himalayas. Our results show that the more frequent EDW drivers in all regions and seasons are the changes in albedo and in downward thermal radiation and this is reflected in both daytime and nighttime warming. In the Tibetan Plateau-Himalayas and in the Greater Alpine Region, an additional driver is the change in specific humidity. We also find that, while generally the model shows no clear resolution dependence in its ability to simulate the existence of EDW in the different regions, specific EDW characteristics such as its intensity and the relative role of different driving mechanisms may be different in simulations performed at different spatial resolutions. Moreover, we find that the role of internal climate variability can be significant in modulating the EDW signal, as suggested by the spread found in the multi-member ensemble of the EC-Earth experiments which we use.

Functional MRI and Multivariate Autoregressive Models

PubMed Central

Rogers, Baxter P.; Katwal, Santosh B.; Morgan, Victoria L.; Asplund, Christopher L.; Gore, John C.

2010-01-01

Connectivity refers to the relationships that exist between different regions of the brain. In the context of functional magnetic resonance imaging (fMRI), it implies a quantifiable relationship between hemodynamic signals from different regions. One aspect of this relationship is the existence of small timing differences in the signals in different regions. Delays of 100 ms or less may be measured with fMRI, and these may reflect important aspects of the manner in which brain circuits respond as well as the overall functional organization of the brain. The multivariate autoregressive time series model has features to recommend it for measuring these delays, and is straightforward to apply to hemodynamic data. In this review, we describe the current usage of the multivariate autoregressive model for fMRI, discuss the issues that arise when it is applied to hemodynamic time series, and consider several extensions. Connectivity measures like Granger causality that are based on the autoregressive model do not always reflect true neuronal connectivity; however, we conclude that careful experimental design could make this methodology quite useful in extending the information obtainable using fMRI. PMID:20444566

Medicare-certified home health services: national and regional supply in the 1980s.

PubMed Central

Scalzi, C C; Zinn, J S; Guilfoyle, M J; Perdue, S T

1994-01-01

The number of Medicare-certified home health agencies nearly doubled from 1980 to 1990. Using Health Care Financing Administration data, this study documented national and regional patterns of entry and exist by Medicare home health providers from 1980 to 1990. Nationally, agency origination rates accelerated during the early 1980s and then dropped abruptly in the second half of the decade. The proprietary sector, accounting for approximately 42% of agencies in existence during the period of the study, exhibited the greatest volatility. Regional differences are also evident. Both expansion and contraction in Medicare home health services appear to be a response to the incentives of legislation implemented during this period. PMID:7943487

[Characteristics and management of ST-elevation myocardial infarction in France: Regional variations in 2010].

PubMed

Sokoloff, A; Lefèvre, G; Teixeira, N; Puymirat, E; Beygui, F; Vanzetto, G; Richard, P; Khalife, K; Blanchard, D; Gilard, M; Coste, P; Farah, B; Elbaz, M; Leclercq, F; Ferrari, E; Bonnet, J-L; Meyer, P; Belle, L; Funck, F; Motreff, P; Virot, P; Geugniaud, P-Y; Ferrières, J; Simon, T; Danchin, N

2015-12-01

Data on regional variations in the characteristics, management and early outcome of patients admitted with ST-elevation myocardial infarction (STEMI) in France are limited. We used data from the FAST-MI 2010 registry to determine whether regional specificities existed, dividing the French territory into 6 larger geographical regions. Variations in the patients' characteristics were found, partly related to regional variations in demography. Acute reperfusion strategy showed more use of primary percutaneous coronary intervention in the greater Paris area, compared to other regions, which would be expected owing to geography and local availability of catheterization laboratories. Overall, however, in-hospital management showed more similarities than differences across regions. Complications, and in particular in-hospital mortality, did not differ significantly among regions. Copyright © 2015. Published by Elsevier SAS.

Large Differences in Global and Regional Total Soil Carbon Stock Estimates Based on SoilGrids, HWSD, and NCSCD: Intercomparison and Evaluation Based on Field Data From USA, England, Wales, and France

NASA Astrophysics Data System (ADS)

Tifafi, Marwa; Guenet, Bertrand; Hatté, Christine

2018-01-01

Soils are the major component of the terrestrial ecosystem and the largest organic carbon reservoir on Earth. However, they are a nonrenewable natural resource and especially reactive to human disturbance and climate change. Despite its importance, soil carbon dynamics is an important source of uncertainty for future climate predictions and there is a growing need for more precise information to better understand the mechanisms controlling soil carbon dynamics and better constrain Earth system models. The aim of our work is to compare soil organic carbon stocks given by different global and regional databases that already exist. We calculated global and regional soil carbon stocks at 1 m depth given by three existing databases (SoilGrids, the Harmonized World Soil Database, and the Northern Circumpolar Soil Carbon Database). We observed that total stocks predicted by each product differ greatly: it is estimated to be around 3,400 Pg by SoilGrids and is about 2,500 Pg according to Harmonized World Soil Database. This difference is marked in particular for boreal regions where differences can be related to high disparities in soil organic carbon concentration. Differences in other regions are more limited and may be related to differences in bulk density estimates. Finally, evaluation of the three data sets versus ground truth data shows that (i) there is a significant difference in spatial patterns between ground truth data and compared data sets and that (ii) data sets underestimate by more than 40% the soil organic carbon stock compared to field data.

A simple and rapid method for preparing the whole section of starchy seed to investigate the morphology and distribution of starch in different regions of seed.

PubMed

Zhao, Lingxiao; Pan, Ting; Guo, Dongwei; Wei, Cunxu

2018-01-01

Storage starch in starchy seed influences the seed weight and texture, and determines its applications in food and nonfood industries. Starch granules from different plant sources have significantly different shapes and sizes, and even more the difference exists in the different regions of the same tissue. Therefore, it is very important to in situ investigate the morphology and distribution of starch in the whole seed. However, a simple and rapid method is deficient to prepare the whole section of starchy seed for investigating the morphology and distribution of starch in the whole seeds for a large number of samples. A simple and rapid method was established to prepare the whole section of starchy seed, especially for floury seed, in this study. The whole seeds of translucent and chalky rice, vitreous and floury maize, and normal barley and wheat were sectioned successfully using the newly established method. The iodine-stained section clearly exhibited the shapes and size of starch granules in different regions of seed. The starch granules with different morphologies and iodine-staining colors existed regionally in the seeds of high-amylose rice and maize. The sections of lotus and kidney bean seeds also showed the feasibility of this method for starchy non-cereal seeds. The simple and rapid method was proven effective for preparing the whole sections of starchy seeds. The whole section of seed could be used to investigate the morphology and distribution of starch granules in different regions of the whole seed. The method was especially suitable for large sample numbers to investigate the starch morphology in short time.

Regional Differences in Rat Vaginal Smooth Muscle Contractility and Morphology

PubMed Central

Skoczylas, Laura C.; Jallah, Zegbeh; Sugino, Yoshio; Stein, Suzan E.; Feola, Andrew; Yoshimura, Naoki

2013-01-01

The objective of this study was to define the regional differences in rat vaginal smooth muscle contractility and morphology. We evaluated circumferential segments from the proximal, middle, and distal rat vagina (n = 21) in vitro. Contractile responses to carbachol, phenylephrine, potassium chloride, and electrical field stimulation (EFS) were measured. Immunohistochemical analyses were also performed. The dose–response curves for carbachol- and phenylephrine-dependent contractions were different in the distal (P = .05, P = .04) compared to the proximal/middle regions. Adjusted for region-dependent changes in contractility, the distal vagina generated lower force in response to carbachol and higher force in response to phenylephrine. There was less force with increasing EFS frequency in the distal (P = .03), compared to the proximal/middle regions. Cholinergic versus adrenergic nerves were more frequent in the proximal region (P = .03). In summary, the results indicate that functional and morphological differences in smooth muscle and nerve fibers of the distal versus proximal/middle regions of the vagina exist. PMID:23298869

IR Spectra of Different O2-Content Hemoglobin from Computational Study: Promising Detector of Hemoglobin Variant in Medical Diagnosis.

PubMed

Zhou, Su-Qin; Chen, Tu-Nan; Ji, Guang-Fu; Wang, En-Ren

2017-06-01

IR spectra of heme and different O 2 -content hemoglobin were studied by the quantum computation method at the molecule level. IR spectra of heme and different O 2 -content hemoglobin were quantificationally characterized from 0 to 100 THz. The IR spectra of oxy-heme and de-oxy-heme are obviously different at the frequency regions of 9.08-9.48, 38.38-39.78, 50.46-50.82, and 89.04-91.00 THz. At 24.72 THz, there exists the absorption peak for oxy-heme, whereas there is not the absorption peak for de-oxy-heme. Whether the heme contains Fe-O-O bond or not has the great influence on its IR spectra and vibration intensities of functional groups in the mid-infrared area. The IR adsorption peak shape changes hardly for different O 2 -content hemoglobin. However, there exist three frequency regions corresponding to the large change of IR adsorption intensities for containing-O 2 hemoglobin in comparison with de-oxy-hemoglobin, which are 11.08-15.93, 44.70-50.22, and 88.00-96.68 THz regions, respectively. The most differential values with IR intensity of different O 2 -content hemoglobin all exceed 1.0 × 10 4  L mol -1  cm -1 . With the increase of oxygen content, the absorption peak appears in the high-frequency region for the containing-O 2 hemoglobin in comparison with de-oxy-hemoglobin. The more the O 2 -content is, the greater the absorption peak is at the high-frequency region. The IR spectra of different O 2 -content hemoglobin are so obviously different in the mid-infrared region that it is very easy to distinguish the hemoglobin variant by means of IR spectra detector. IR spectra of hemoglobin from quantum computation can provide scientific basis and specific identification of hemoglobin variant resulting from different O 2 contents in medical diagnosis.

Sex differences in visual attention to sexually explicit videos: a preliminary study.

PubMed

Tsujimura, Akira; Miyagawa, Yasushi; Takada, Shingo; Matsuoka, Yasuhiro; Takao, Tetsuya; Hirai, Toshiaki; Matsushita, Masateru; Nonomura, Norio; Okuyama, Akihiko

2009-04-01

Although men appear to be more interested in sexual stimuli than women, this difference is not completely understood. Eye-tracking technology has been used to investigate visual attention to still sexual images; however, it has not been applied to moving sexual images. To investigate whether sex difference exists in visual attention to sexual videos. Eleven male and 11 female healthy volunteers were studied by our new methodology. The subjects viewed two sexual videos (one depicting sexual intercourse and one not) in which several regions were designated for eye-gaze analysis in each frame. Visual attention was measured across each designated region according to gaze duration. Sex differences, the region attracting the most attention, and visually favored sex were evaluated. In the nonintercourse clip, gaze time for the face and body of the actress was significantly shorter among women than among men. Gaze time for the face and body of the actor and nonhuman regions was significantly longer for women than men. The region attracting the most attention was the face of the actress for both men and women. Men viewed the opposite sex for a significantly longer period than did women, and women viewed their own sex for a significantly longer period than did men. However, gaze times for the clip showing intercourse were not significantly different between sexes. A sex difference existed in visual attention to a sexual video without heterosexual intercourse; men viewed the opposite sex for longer periods than did women, and women viewed the same sex for longer periods than did men. There was no statistically significant sex difference in viewing patterns in a sexual video showing heterosexual intercourse, and we speculate that men and women may have similar visual attention patterns if the sexual stimuli are sufficiently explicit.

Quantifying Geographic Variation in Health Care Outcomes in the United States before and after Risk-Adjustment.

PubMed

Rosenberg, Barry L; Kellar, Joshua A; Labno, Anna; Matheson, David H M; Ringel, Michael; VonAchen, Paige; Lesser, Richard I; Li, Yue; Dimick, Justin B; Gawande, Atul A; Larsson, Stefan H; Moses, Hamilton

2016-01-01

Despite numerous studies of geographic variation in healthcare cost and utilization at the local, regional, and state levels across the U.S., a comprehensive characterization of geographic variation in outcomes has not been published. Our objective was to quantify variation in US health outcomes in an all-payer population before and after risk-adjustment. We used information from 16 independent data sources, including 22 million all-payer inpatient admissions from the Healthcare Cost and Utilization Project (which covers regions where 50% of the U.S. population lives) to analyze 24 inpatient mortality, inpatient safety, and prevention outcomes. We compared outcome variation at state, hospital referral region, hospital service area, county, and hospital levels. Risk-adjusted outcomes were calculated after adjusting for population factors, co-morbidities, and health system factors. Even after risk-adjustment, there exists large geographical variation in outcomes. The variation in healthcare outcomes exceeds the well publicized variation in US healthcare costs. On average, we observed a 2.1-fold difference in risk-adjusted mortality outcomes between top- and bottom-decile hospitals. For example, we observed a 2.3-fold difference for risk-adjusted acute myocardial infarction inpatient mortality. On average a 10.2-fold difference in risk-adjusted patient safety outcomes exists between top and bottom-decile hospitals, including an 18.3-fold difference for risk-adjusted Central Venous Catheter Bloodstream Infection rates. A 3.0-fold difference in prevention outcomes exists between top- and bottom-decile counties on average; including a 2.2-fold difference for risk-adjusted congestive heart failure admission rates. The population, co-morbidity, and health system factors accounted for a range of R2 between 18-64% of variability in mortality outcomes, 3-39% of variability in patient safety outcomes, and 22-70% of variability in prevention outcomes. The amount of variability in health outcomes in the U.S. is large even after accounting for differences in population, co-morbidities, and health system factors. These findings suggest that: 1) additional examination of regional and local variation in risk-adjusted outcomes should be a priority; 2) assumptions of uniform hospital quality that underpin rationale for policy choices (such as narrow insurance networks or antitrust enforcement) should be challenged; and 3) there exists substantial opportunity for outcomes improvement in the US healthcare system.

Essays on the Digital Divide--Explorations through Global, National and Individual Lenses

ERIC Educational Resources Information Center

Skaletsky, Maria

2013-01-01

The Digital Divide has emerged as an important research and policy issue during the past thirty years. The divide exists at different levels, such as global, regional and individual levels. While extensive research already exists on this subject, the complexity of the issue presents opportunities for further research. In particular, there is ample…

Challenges in characterizing a parcelized forest landscape: why metric, scale and threshold matter

Treesearch

Michael A. Kilgore; Stephanie A. Snyder; Kayla Block-Torgerson; Steven J. Taff

2013-01-01

Several metrics have been cited in the literature as being useful characterizations of forest land parcelization. Yet no agreed-upon standard measure exists which creates difficulties in identifying where parcelization is occurring as well as comparing the magnitude of its occurrence across different studies and geographic regions. We evaluated three existing (average...

Co-existence and switching between fast and Ω-slow wind solutions in rapidly rotating massive stars

NASA Astrophysics Data System (ADS)

Araya, I.; Curé, M.; ud-Doula, A.; Santillán, A.; Cidale, L.

2018-06-01

Most radiation-driven winds of massive stars can be modelled with m-CAK theory, resulting in the so-called fast solution. However, the most rapidly rotating stars among them, especially when the rotational speed is higher than {˜ } 75 per cent of the critical rotational speed, can adopt a different solution, the so-called Ω-slow solution, characterized by a dense and slow wind. Here, we study the transition region of the solutions where the fast solution changes to the Ω-slow solution. Using both time-steady and time-dependent numerical codes, we study this transition region for various equatorial models of B-type stars. In all cases, in a certain range of rotational speeds we find a region where the fast and the Ω-slow solution can co-exist. We find that the type of solution obtained in this co-existence region depends stongly on the initial conditions of our models. We also test the stability of the solutions within the co-existence region by performing base-density perturbations in the wind. We find that under certain conditions, the fast solution can switch to the Ω-slow solution, or vice versa. Such solution-switching may be a possible contributor of material injected into the circumstellar environment of Be stars, without requiring rotational speeds near critical values.

Cancer mortality rates in Appalachia: descriptive epidemiology and an approach to explaining differences in outcomes.

PubMed

Blackley, David; Behringer, Bruce; Zheng, Shimin

2012-08-01

Cancer is a leading cause of death in the Appalachian region of the United States. Existing studies compare regional mortality rates to those of the entire nation. We compare cancer mortality rates in Appalachia to those of the nation, with additional comparisons of Appalachian and non-Appalachian counties within the 13 states that contain the Appalachian region. Lung/bronchus, colorectal, female breast and cervical cancers, as well as all cancers combined, are included in analysis. Linear regression is used to identify independent associations between ecological socioeconomic and demographic variables and county-level cancer mortality outcomes. There is a pattern of high cancer mortality rates in the 13 states containing Appalachia compared to the rest of the United States. Mortality rate differences exist between Appalachian and non-Appalachian counties within the 13 states, but these are not consistent. Lung cancer is a major problem in Appalachia; most Appalachian counties within the 13 states have significantly higher mortality rates than in-state, non-Appalachian counterparts. Mortality rates from all cancers combined also appear to be worse overall within Appalachia, but part of this disparity is likely driven by lung cancer. Education and income are generally associated with cancer mortality, but differences in the strength and direction of these associations exist depending on location and cancer type. Improving high school graduation rates in Appalachia could result in a meaningful long term reduction in lung cancer mortality. The relative importance of household income level to cancer outcomes may be greater outside the Appalachian regions within these states.

Regional differences in gender promotion and scholarly productivity in otolaryngology.

PubMed

Eloy, Jean Anderson; Mady, Leila J; Svider, Peter F; Mauro, Kevin M; Kalyoussef, Evelyne; Setzen, Michael; Baredes, Soly; Chandrasekhar, Sujana S

2014-03-01

To identify whether regional differences exist in gender disparities in scholarly productivity and faculty rank among academic otolaryngologists. Academic otolaryngologists' bibliometric data analyses. Online faculty listings from 98 otolaryngology departments were organized by gender, academic rank, fellowship training status, and institutional location. The Scopus database was used to assess bibliometrics of these otolaryngologists, including the h-index, number of publications, and publication experience. Analysis included 1127 otolaryngologists, 916 men (81.3%) and 211 women (18.7%). Female faculty comprised 15.4% in the Midwest, 18.8% in the Northeast, 21.3% in the South, and 19.0% in the West (P = .44). Overall, men obtained significantly higher senior academic ranks (associate professor or professor) compared to women (59.8% vs. 40.2%, P < .0001). Regional gender differences in senior faculty were found in the South (59.8% men vs. 37.3% women, P = .0003) and Northeast (56.4% men vs. 24.1% women, P < .0001) with concomitant gender differences in scholarly impact, as measured by the h-index (South, P = .0003; Northeast, P = .0001). Among geographic subdivisions, female representation at senior ranks was lowest in the Mid-Atlantic (22.0%), New England (30.8%), and West South Central (33.3%), while highest in Pacific (60.0%) and Mountain (71.4%) regions. No regional gender differences were found in fellowship training patterns (P-values > .05). Gender disparities in academic rank and scholarly productivity exist most notably in the Northeast, where women in otolaryngology are most underrepresented relative to men at senior academic ranks and in scholarly productivity.

Geographic and income variations in age at diagnosis and incidence of chronic myeloid leukemia.

PubMed

Mendizabal, Adam M; Younes, Naji; Levine, Paul H

2016-01-01

Developing countries have a younger population of CML patients than developed countries. Patterns of age at diagnosis and incidence by geography and gross national income (GNI) are not well understood. A population-based descriptive study was conducted using data from the International Agency for Research on Cancer's population-based registry compilation. Geographical regions were classified according to the United Nations World Macro Regions and Components. Age-Standardized Incidence Rates (ASR) were adjusted to the World Standard Population. Poisson regression was used to assess age-specific interactions. 57.2% were male among 33,690 diagnoses. Median age at diagnosis was lowest in Africa and Asia (47 years) and highest in Oceania (72 years). ASR was lowest in African males (0.61 per 100,000) and Asian females (0.55 per 100,000) and highest in Oceania males and females (1.78 and 0.96 per 100,000, respectively). A significant interaction (p < 0.0001) between age (<50 years and >50 years) and region exists; no significant differences were seen by region in the <50 age-group while significant differences by region exist in the >50 age group. Population-based estimates suggest that the median age at diagnosis and incidence varies by region. Geographic and income heterogeneity suggest an important effect of environment that warrants further studies.

Power law f(𝒢,T) gravity models supporting wormhole solutions

NASA Astrophysics Data System (ADS)

Shamir, M. Farasat; Ahmad, Mushtaq

This work provides some feasible regions for the existence of traversable wormhole geometries in modified f(𝒢,T) gravity. For this purpose, three different matter contents have been studied with special emphasis on anisotropic fluid by considering a specific f(𝒢,T) gravity power law model. It has been shown that the null energy conditions for the effective energy-momentum tensor are widely violated for the ordinary matter content. However, some small feasible regions to support the wormhole solutions have been noted. Furthermore, the stability of the anisotropic feasible regions for the wormhole solutions has been discussed. It is concluded that the wormhole geometries threaded by the ordinary matter actually exist and are well stable in f(𝒢,T) gravity.

Analysis of regional-scale vegetation dynamics of Mexico using stratified AVHRR NDVI data. [Normalized Difference Vegetaion Index

NASA Technical Reports Server (NTRS)

Turcotte, Kevin M.; Kramber, William J.; Venugopal, Gopalan; Lulla, Kamlesh

1989-01-01

Previous studies have shown that a good relationship exists between AVHRR Normalized Difference Vegetation Index (NDVI) measurements, and both regional-scale patterns of vegetation seasonality and productivity. Most of these studies used known samples of vegetation types. An alternative approach, and the objective was to examine the above relationships by analyzing one year of AVHRR NDVI data that was stratified using a small-scale vegetation map of Mexico. The results show that there is a good relationship between AVHRR NDVI measurements and regional-scale vegetation dynamics of Mexico.

40 shades of black: regional differences in vegetation response to a changing human influence in the Low Countries during the Dark Ages (AD 300-1000).

NASA Astrophysics Data System (ADS)

Gouw-Bouman, Marjolein T. I. J.; Donders, Timme H.; Hoek, Wim Z.

2016-04-01

During the Dark Ages, which includes the Late Roman Period (LRP, AD 300-500) and the Early Middle Ages (EMA, AD 500-1000), large scale vegetation development in Northwestern Europe is generally characterized by a forest regeneration. This forest redevelopment phase was not uniformous across the Netherlands. A comparison between existing pollen records shows that forest redevelopment started earlier and was more severe in the southern part of the Netherlands than in the northeastern Netherlands. The prevailing view advocates that the forest redevelopment is the result of a diminishing human influence on the landscape due to the collapse of the Roman Empire. Following this view, regional changes in forest regeneration are explained by varying population densities. However, existing climate-records indicate a colder and wetter climate during the Dark Ages and the geomorphological record points to a changing landscape. How and to what extent these climatic and environmental changes contributed to the changes in vegetation development or even to the decline of the Roman Empire is largely unknown. To understand the relative importance of the factors (climate, environment, economy and demography) influencing vegetation development it is important to accurately map regional differences in vegetation both on a regional and extra-regional scale. For an extra-regional overview all available pollen records in the Netherlands from this period are compiled to show differences in amplitude of the vegetation development during the Dark Ages. On a regional scale, vegetation reconstruction maps have been produced reflecting the influence of geological/geomorphological factors.

Genetic diversity based on 28S rDNA sequences among populations of Culex quinquefasciatus collected at different locations in Tamil Nadu, India.

PubMed

Sakthivelkumar, S; Ramaraj, P; Veeramani, V; Janarthanan, S

2015-09-01

The basis of the present study was to distinguish the existence of any genetic variability among populations of Culex quinquefasciatus which would be a valuable tool in the management of mosquito control programmes. In the present study, population of Cx. quinquefasciatus collected at different locations in Tamil Nadu were analyzed for their genetic variation based on 28S rDNA D2 region nucleotide sequences. A high degree of genetic polymorphism was detected in the sequences of D2 region of 28S rDNA on the predicted secondary structures in spite of high nucleotide sequence similarity. The findings based on secondary structure using rDNA sequences suggested the existence of a complex genotypic diversity of Cx. quinquefasciatus population collected at different locations of Tamil Nadu, India. This complexity in genetic diversity in a single mosquito population collected at different locations is considered an important issue towards their influence and nature of vector potential of these mosquitoes.

Cortical Changes Across the Autism Lifespan.

PubMed

Osipowicz, Karol; Bosenbark, Danielle D; Patrick, Kristina E

2015-08-01

Although it is widely accepted that autism spectrum disorder (ASD) involves neuroanatomical abnormalities and atypical neurodevelopmental patterns, there is little consensus regarding the precise pattern of neuroanatomical differences or how these differences relate to autism symptomology. Furthermore, there is limited research related to neuroanatomical correlates of autism symptomology in individuals with ASD and the studies that do exist primarily include small samples. This study was the first to investigate gray matter (GM) changes throughout the ASD lifespan, using voxel-based morphometry to determine whether significant differences exist in the GM volumes of a large sample of individuals with ASD compared to age- and IQ-matched typical controls. We examined GM volume across the lifespan in 531 individuals diagnosed with ASD and 571 neurotypical controls, aged 7-64. We compared groups and correlated GM with age and autism severity in the ASD group. Findings suggest bilateral decreased GM volume for individuals with ASD in regions extending from the thalamus to the cerebellum, anterior medial temporal lobes, and orbitofrontal regions. Higher autism severity was associated with decreased GM volumes in prefrontal cortex, inferior parietal and temporal regions, and temporal poles. Similar relationships were found between GM volume and age. ASD diagnosis and severity were not associated with increased GM volumes in any region. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

Increasing the utility of regional water table maps: a new method for estimating groundwater recharge

NASA Astrophysics Data System (ADS)

Gilmore, T. E.; Zlotnik, V. A.; Johnson, M.

2017-12-01

Groundwater table elevations are one of the most fundamental measurements used to characterize unconfined aquifers, groundwater flow patterns, and aquifer sustainability over time. In this study, we developed an analytical model that relies on analysis of groundwater elevation contour (equipotential) shape, aquifer transmissivity, and streambed gradient between two parallel, perennial streams. Using two existing regional water table maps, created at different times using different methods, our analysis of groundwater elevation contours, transmissivity and streambed gradient produced groundwater recharge rates (42-218 mm yr-1) that were consistent with previous independent recharge estimates from different methods. The three regions we investigated overly the High Plains Aquifer in Nebraska and included some areas where groundwater is used for irrigation. The three regions ranged from 1,500 to 3,300 km2, with either Sand Hills surficial geology, or Sand Hills transitioning to loess. Based on our results, the approach may be used to increase the value of existing water table maps, and may be useful as a diagnostic tool to evaluate the quality of groundwater table maps, identify areas in need of detailed aquifer characterization and expansion of groundwater monitoring networks, and/or as a first approximation before investing in more complex approaches to groundwater recharge estimation.

Regional and seasonal analyses of weights in growing Angus cattle.

PubMed

Bradford, H L; Fragomeni, B O; Bertrand, J K; Lourenco, D A L; Misztal, I

2016-10-01

This study evaluated the impact of region and season on growth in Angus seed stock. To assess geographic differences, the United States was partitioned into 9 regions based on similar climate and topography related to cow-calf production. Seasonal effects were associated with the month that animals were weighed. The American Angus Association provided growth data, and records were assigned to regions based on the owner's zip code. Most Angus cattle were in the Cornbelt, Lower Plains, Rocky Mountain, Upper Plains, and Upper South regions, with proportionally fewer Angus in Texas compared with the national cow herd. Most calves were born in the spring, especially February and March. Weaning weights (WW; = 49,886) and yearling weights (YW; = 45,168) were modeled with fixed effects of age-of-dam class (WW only), weigh month, region, month-region interaction, and linear covariate of age. Random effects included contemporary group nested within month-region combination and residual. The significant month-region interaction ( < 0.0001) was expected because of the diverse production environments across the country and cyclical fluctuations in forage availability. Additionally, significant seasonal contrasts existed for several regions. Fall-born calves were heavier ( < 0.01) than spring-born calves in the hot and humid Lower South region coinciding with fall being the primary calving season. The North and Upper Plains regions had heavier, spring-born calves ( < 0.01), more than 90% spring calving, and colder climates. Interestingly, no seasonal WW or YW differences existed between spring- and fall-born calves in the upper South region despite challenging environmental conditions. Angus seed stock producers have used calving seasons to adapt to the specific environmental conditions in their regions and to optimize growth in young animals.

Measuring Polycentricity of Mega-City Regions in China Based on the Intercity Migration Flows

NASA Astrophysics Data System (ADS)

Mu, Xiaoyan; Yeh, Anthony G. O.

2016-06-01

This paper uses the intercity migration flows to examine relations between Chinese cities, identify the important mega-city regions and measure each region's polycentricity from an interaction perspective. Data set contains the long-term residential migration trajectories of three million Sina weibo users across 345 cities. Cities with close connectivity deployed around one or several mega cities are identified as mega-city regions. Features of the mega-city regions are characterized by the strength of migration flows, density of connections, and regional migration patterns. The results show that the disparities exist in different mega-city regions; most mega-city regions are lack of polycentricity.

Where Are the Teachers? A Policy Report on Teacher Attendance in the Pacific Region.

ERIC Educational Resources Information Center

Uehara, Denise L.

This report makes policy implementers and educators aware of the importance of work attendance and its relation to student outcomes. It also encourages policymakers to better implement and supplement existing policies through different strategy options. The focus is on the Pacific region. Rather than recommending a punitive approach, the report…

A comparison of regional and national values for recovering threatened and endangered marine species in the United States.

PubMed

Wallmo, Kristy; Lew, Daniel K

2016-09-01

It is generally acknowledged that willingness-to-pay (WTP) estimates for environmental goods exhibit some degree of spatial variation. In a policy context, spatial variation in threatened and endangered species values is important to understand, as the benefit stream from policies affecting threatened and endangered species may vary locally, regionally, or among certain population segments. In this paper we present WTP estimates for eight different threatened and endangered marine species estimated from a stated preference choice experiment. WTP is estimated at two different spatial scales: (a) a random sample of over 5000 U.S. households and (b) geographically embedded samples (relative to the U.S. household sample) of nine U.S. Census regions. We conduct region-to-region and region-to-nation statistical comparisons to determine whether species values differ among regions and between each region and the entire U.S. Our results show limited spatial variation between national values and values estimated from regionally embedded samples, and differences are only found for three of the eight species. More variation exists between regions, and for all species there is a significant difference in at least one region-to-region comparison. Given that policy analyses involving threatened and endangered marine species can often be regional in scope (e.g., ecosystem management) or may disparately affect different regions, our results should be of high interest to the marine management community. Published by Elsevier Ltd.

Trends in Regionalization of Care for ST-Segment Elevation Myocardial Infarction.

PubMed

Hsia, Renee Y; Sabbagh, Sarah; Sarkar, Nandita; Sporer, Karl; Rokos, Ivan C; Brown, John F; Brindis, Ralph G; Guo, Joanna; Shen, Yu-Chu

2017-10-01

California has led successful regionalized efforts for several time-critical medical conditions, including ST-segment elevation myocardial infarction (STEMI), but no specific mandated protocols exist to define regionalization of care. We aimed to study the trends in regionalization of care for STEMI patients in the state of California and to examine the differences in patient demographic, hospital, and county trends. Using survey responses collected from all California emergency medical services (EMS) agencies, we developed four categories - no, partial, substantial, and complete regionalization - to capture prehospital and inter-hospital components of regionalization in each EMS agency's jurisdiction between 2005-2014. We linked the survey responses to 2006 California non-public hospital discharge data to study the patient distribution at baseline. STEMI regionalization-of-care networks steadily developed across California. Only 14% of counties were regionalized in 2006, accounting for 42% of California's STEMI patient population, but over half of these counties, representing 86% of California's STEMI patient population, reached complete regionalization in 2014. We did not find any dramatic differences in underlying patient characteristics based on regionalization status; however, differences in hospital characteristics were relatively substantial. Potential barriers to achieving regionalization included competition, hospital ownership, population density, and financial challenges. Minimal differences in patient characteristics can establish that patient differences unlikely played any role in influencing earlier or later regionalization and can provide a framework for future analyses evaluating the impact of regionalization on patient outcomes.

Spatial Analysis of China Province-level Perinatal Mortality

PubMed Central

XIANG, Kun; SONG, Deyong

2016-01-01

Background: Using spatial analysis tools to determine the spatial patterns of China province-level perinatal mortality and using spatial econometric model to examine the impacts of health care resources and different socio-economic factors on perinatal mortality. Methods: The Global Moran’s I index is used to examine whether the spatial autocorrelation exists in selected regions and Moran’s I scatter plot to examine the spatial clustering among regions. Spatial econometric models are used to investigate the spatial relationships between perinatal mortality and contributing factors. Results: The overall Moran’s I index indicates that perinatal mortality displays positive spatial autocorrelation. Moran’s I scatter plot analysis implies that there is a significant clustering of mortality in both high-rate regions and low-rate regions. The spatial econometric models analyses confirm the existence of a direct link between perinatal mortality and health care resources, socio-economic factors. Conclusions: Since a positive spatial autocorrelation has been detected in China province-level perinatal mortality, the upgrading of regional economic development and medical service level will affect the mortality not only in region itself but also its adjacent regions. PMID:27398334

The structural, connectomic and network covariance of the human brain.

PubMed

Irimia, Andrei; Van Horn, John D

2013-02-01

Though it is widely appreciated that complex structural, functional and morphological relationships exist between distinct areas of the human cerebral cortex, the extent to which such relationships coincide remains insufficiently appreciated. Here we determine the extent to which correlations between brain regions are modulated by either structural, connectomic or network-theoretic properties using a structural neuroimaging data set of magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) volumes acquired from N=110 healthy human adults. To identify the linear relationships between all available pairs of regions, we use canonical correlation analysis to test whether a statistically significant correlation exists between each pair of cortical parcels as quantified via structural, connectomic or network-theoretic measures. In addition to this, we investigate (1) how each group of canonical variables (whether structural, connectomic or network-theoretic) contributes to the overall correlation and, additionally, (2) whether each individual variable makes a significant contribution to the test of the omnibus null hypothesis according to which no correlation between regions exists across subjects. We find that, although region-to-region correlations are extensively modulated by structural and connectomic measures, there are appreciable differences in how these two groups of measures drive inter-regional correlation patterns. Additionally, our results indicate that the network-theoretic properties of the cortex are strong modulators of region-to-region covariance. Our findings are useful for understanding the structural and connectomic relationship between various parts of the brain, and can inform theoretical and computational models of cortical information processing. Published by Elsevier Inc.

Acceleration of Image Segmentation Algorithm for (Breast) Mammogram Images Using High-Performance Reconfigurable Dataflow Computers

PubMed Central

Filipovic, Nenad D.

2017-01-01

Image segmentation is one of the most common procedures in medical imaging applications. It is also a very important task in breast cancer detection. Breast cancer detection procedure based on mammography can be divided into several stages. The first stage is the extraction of the region of interest from a breast image, followed by the identification of suspicious mass regions, their classification, and comparison with the existing image database. It is often the case that already existing image databases have large sets of data whose processing requires a lot of time, and thus the acceleration of each of the processing stages in breast cancer detection is a very important issue. In this paper, the implementation of the already existing algorithm for region-of-interest based image segmentation for mammogram images on High-Performance Reconfigurable Dataflow Computers (HPRDCs) is proposed. As a dataflow engine (DFE) of such HPRDC, Maxeler's acceleration card is used. The experiments for examining the acceleration of that algorithm on the Reconfigurable Dataflow Computers (RDCs) are performed with two types of mammogram images with different resolutions. There were, also, several DFE configurations and each of them gave a different acceleration value of algorithm execution. Those acceleration values are presented and experimental results showed good acceleration. PMID:28611851

Acceleration of Image Segmentation Algorithm for (Breast) Mammogram Images Using High-Performance Reconfigurable Dataflow Computers.

PubMed

Milankovic, Ivan L; Mijailovic, Nikola V; Filipovic, Nenad D; Peulic, Aleksandar S

2017-01-01

Image segmentation is one of the most common procedures in medical imaging applications. It is also a very important task in breast cancer detection. Breast cancer detection procedure based on mammography can be divided into several stages. The first stage is the extraction of the region of interest from a breast image, followed by the identification of suspicious mass regions, their classification, and comparison with the existing image database. It is often the case that already existing image databases have large sets of data whose processing requires a lot of time, and thus the acceleration of each of the processing stages in breast cancer detection is a very important issue. In this paper, the implementation of the already existing algorithm for region-of-interest based image segmentation for mammogram images on High-Performance Reconfigurable Dataflow Computers (HPRDCs) is proposed. As a dataflow engine (DFE) of such HPRDC, Maxeler's acceleration card is used. The experiments for examining the acceleration of that algorithm on the Reconfigurable Dataflow Computers (RDCs) are performed with two types of mammogram images with different resolutions. There were, also, several DFE configurations and each of them gave a different acceleration value of algorithm execution. Those acceleration values are presented and experimental results showed good acceleration.

Sinistrals' Upper Hand: Evidence for Handedness Differences in the Representation of Body Space

ERIC Educational Resources Information Center

Hach, Sylvia; Schutz-Bosbach, Simone

2010-01-01

A difference in the perception of extrapersonal space has been shown to exist between dextrals and sinistrals. On the classical line bisection task, this difference is evident in a greater left bias for dextrals compared to sinistrals. Different modalities and regions of space can be affected. However, it has not yet been investigated whether a…

Analysis of Stakeholder's Behaviours for an Improved Management of an Agricultural Coastal Region in Oman

NASA Astrophysics Data System (ADS)

Khatri, Ayisha Al; Jens, Grundmann; der Weth Rüdiger, van; Niels, Schütze

2015-04-01

Al Batinah coastal area is the main agricultural region in Oman. Agriculture is concentrated in Al Batinah, because of more fertile soils and easier access to water in the form of groundwater compared to other administrative areas in the country. The region now is facing a problem as a result of over abstraction of fresh groundwater for irrigation from the main aquifer along the coast. This enforces the inflow of sea water into the coastal aquifer and causes salinization of the groundwater. As a consequence the groundwater becomes no longer suitable for irrigation which impacts the social and economical situation of farmers as well as the environment. Therefore, the existing situation generates conflicts between different stakeholders regarding water availability, sustainable aquifer management, and profitable agricultural production in Al Batinah region. Several management measures to maintain the groundwater aquifer in the region, were implemented by the government. However, these solutions showed only limited successes for the existing problem. The aim of this study now is to evaluate the implementation potential of several management interventions and their combinations by analysing opinions and responses of all relevant stakeholders in the region. This is done in order to identify potential conflicts among stakeholders to a participatory process within the frame of an integrated water resources management and to support decision makers in taking more informed decisions. Questionnaires were designed for collecting data from different groups of stakeholders e.g. water professionals, farmers from the study area and decision makers of different organizations and ministries. These data were analysed statistically for each group separately as well as regarding relations amongst groups by using the SPSS (Statistical Package for Social Science) software package. Results show, that the need to improve the situation is supported by all groups. However, significant differences exist between groups on how to achieve this improvement, since farmers prefer management interventions operating more on the water resources side while decision makers support measures for a better management on the water demand side. Furthermore, the opinions within single groups are sometimes contradicting for several management interventions. The use of more advanced statistical methods like discriminant analysis or Bayesian network allow for identifying factors and drivers to explain these differences. Both approaches, will help to understand stakeholder's behaviours and to evaluate the implementation potential of several management interventions. Keywords IWRM, Stakeholder participation, field survey, statistical analysis, Oman

Regional differences of the contractile responses to acetylcholine and neurokinin A in rabbit airway: heterogeneous distribution of the metabolic enzymes.

PubMed

Goroumaru-Shinkai, M; Yamamoto, R; Funayama, N; Takayanagi, I

1992-11-01

1. Experiments were designed to determine whether differences exist in the sensitivity to muscarinic and tachykinin agonists in rabbit airways. 2. The rank order of sensitivity (pD2 value) to acetylcholine was: trachea > proximal bronchus > distal bronchus, whereas no regional difference was observed in the sensitivity to carbamylcholine which is resistant to acetylcholinesterase. 3. Acetylcholinesterase activity was greater in the distal than in the proximal airway. 4. In the absence of the peptidase inhibitor, phosphoramidon, the pD2 values of neurokinin A (NKA) and substance P (SP) in trachea were significantly greater than that in bronchus, whereas no regional difference was observed in the NK1 selective agonist, substance P methyl ester (SPOMe). 5. Application of phosphoramidon (10 microM) to avoid peptide degradation abolished the regional difference of the pD2 values of SP. 6. In conclusion, regional differences in sensitivities to acetylcholine and NKA in the rabbit airway were suggested to be due to distribution to the metabolic enzymes of these drugs.

Population genetics and evaluation of genetic evidence for subspecies in the Semipalmated Sandpiper (Calidris pusilla)

USGS Publications Warehouse

Miller, Mark P.; Gratto-Trevor, Cheri; Haig, Susan M.; Mizrahi, David S.; Mitchell, Melanie M.; Mullins, Thomas D.

2013-01-01

Semipalmated Sandpipers (Calidris pusilla) are among the most common North American shorebirds. Breeding in Arctic North America, this species displays regional differences in migratory pathways and possesses longitudinal bill length variation. Previous investigations suggested that genetic structure may occur within Semipalmated Sandpipers and that three subspecies corresponding to western, central, and eastern breeding groups exist. In this study, mitochondrial control region sequences and nuclear microsatellite loci were used to analyze DNA of birds (microsatellites: n = 120; mtDNA: n = 114) sampled from seven North American locations. Analyses designed to quantify genetic structure and diversity patterns, evaluate genetic evidence for population size changes, and determine if genetic data support the existence of Semipalmated Sandpiper subspecies were performed. Genetic structure based only on the mtDNA data was observed, whereas the microsatellite loci provided no evidence of genetic differentiation. Differentiation among locations and regions reflected allele frequency differences rather than separate phylogenetic groups, and similar levels of genetic diversity were noted. Combined, the two data sets provided no evidence to support the existence of subspecies and were not useful for determining migratory connectivity between breeding sites and wintering grounds. Birds from western and central groups displayed signatures of population expansions, whereas the eastern group was more consistent with a stable overall population. Results of this analysis suggest that the eastern group was the source of individuals that colonized the central and western regions currently utilized by Semipalmated Sandpipers.

Discriminating the Difference between Remote and Close Association with Relation to White-Matter Structural Connectivity

PubMed Central

Wu, Chinglin; Zhong, Suyu; Chen, Hsuehchih

2016-01-01

Remote association is a core ability that influences creative output. In contrast to close association, remote association is commonly agreed to be connected with more original and unique concepts. However, although existing studies have discovered that creativity is closely related to the white-matter structure of the brain, there are no studies that examine the relevance between the connectivity efficiencies and creativity of the brain regions from the perspective of networks. Consequently, this study constructed a brain white matter network structure that consisted of cerebral tissues and nerve fibers and used graph theory to analyze the connection efficiencies among the network nodes, further illuminating the differences between remote and close association in relation to the connectivity of the brain network. Researchers analyzed correlations between the scores of 35 healthy adults with regard to remote and close associations and the connectivity efficiencies of the white-matter network of the brain. Controlling for gender, age, and verbal intelligence, the remote association positively correlated with the global efficiency and negatively correlated with the levels of small-world. A close association negatively correlated with the global efficiency. Notably, the node efficiency in the middle temporal gyrus (MTG) positively correlated with remote association and negatively correlated with close association. To summarize, remote and close associations work differently as patterns in the brain network. Remote association requires efficient and convenient mutual connections between different brain regions, while close association emphasizes the limited connections that exist in a local region. These results are consistent with previous results, which indicate that creativity is based on the efficient integration and connection between different regions of the brain and that temporal lobes are the key regions for discriminating remote and close associations. PMID:27760177

Multiple network alignment via multiMAGNA+.

PubMed

Vijayan, Vipin; Milenkovic, Tijana

2017-08-21

Network alignment (NA) aims to find a node mapping that identifies topologically or functionally similar network regions between molecular networks of different species. Analogous to genomic sequence alignment, NA can be used to transfer biological knowledge from well- to poorly-studied species between aligned network regions. Pairwise NA (PNA) finds similar regions between two networks while multiple NA (MNA) can align more than two networks. We focus on MNA. Existing MNA methods aim to maximize total similarity over all aligned nodes (node conservation). Then, they evaluate alignment quality by measuring the amount of conserved edges, but only after the alignment is constructed. Directly optimizing edge conservation during alignment construction in addition to node conservation may result in superior alignments. Thus, we present a novel MNA method called multiMAGNA++ that can achieve this. Indeed, multiMAGNA++ outperforms or is on par with existing MNA methods, while often completing faster than existing methods. That is, multiMAGNA++ scales well to larger network data and can be parallelized effectively. During method evaluation, we also introduce new MNA quality measures to allow for more fair MNA method comparison compared to the existing alignment quality measures. MultiMAGNA++ code is available on the method's web page at http://nd.edu/~cone/multiMAGNA++/.

Sports participation, physical activity, and health in the European regions.

PubMed

Lera-López, Fernando; Marco, Rocio

2018-08-01

In a context of stagnation of the level of health-enhancing physical activity in Europe, this study examines the geographical stratification of sports participation and physical activity (PA) at the regional level in 28 European countries. While previous research has focused on the national approach, this study considers the regional level across 208 European regions. Individual survey data from the Eurobarometer 80.2 is combined with a regional-level approach to the 208 regions to quantify sports participation and PA at the regional level. The results show important differences and a geographical stratification of sports participation and PA among the European regions, albeit following different patterns. In particular, a north-south gap is identified in terms of PA rates and an east-west gap is detected in terms of sports participation levels. Applying the cluster technique, a taxonomy of four different European regions is developed considering both types of indicators. Finally, the existence of sports spatial spillovers among regions is verified, obtaining a positive autocorrelation among neighbouring regions for being involved in PA and sporting activities. The results may have significant implications in terms of policy measures to improve health through PA and sports participation at the regional level in Europe.

Late-Holocene vegetation dynamics in response to a changing climate and anthropogenic influences - Insights from stratigraphic records and subfossil trees from southeast Lithuania

NASA Astrophysics Data System (ADS)

Edvardsson, Johannes; Stančikaitė, Miglė; Miras, Yannick; Corona, Christophe; Gryguc, Gražyna; Gedminienė, Laura; Mažeika, Jonas; Stoffel, Markus

2018-04-01

To increase our understanding of long-term climate dynamics and its effects on different ecosystems, palaeoclimatic and long-term botanical reconstructions need to be improved, in particular in underutilized geographical regions. In this study, vegetation, (hydro)climate, and land-use changes were documented at two southeast Lithuanian peatland complexes - Čepkeliai and Rieznyčia - for the Late-Holocene period. The documentation was based on a combination of pollen, plant macrofossils, peat stratigraphic records, and subfossil trees. Our results cover the last two millennia and reveal the existence of moist conditions in Southern Lithuania between 300 and 500 CE and from 950 to 1850 CE. Conversely, changes towards warmer and/or dryer conditions have been recorded in 100, 600, and 750 CE, and since the 1850s. Significant differences with other Baltic proxies prevent deriving a complete and precise long-term reconstruction of past hydroclimatic variability at the regional scale. Yet, our results provide an important cornerstone for an improved understanding of regional climate change, i.e. in a region for which only (i) few detailed palaeobotanical studies exist and which has, in addition, been considered as (ii) an ecologically sensitive region at the interface between the temperate and boreal bioclimatic zones.

Building Collections: Recognizing and Appreciating Differences

ERIC Educational Resources Information Center

Krapp, Joanna Vergona

2004-01-01

A huge world exists outside the family. When youngsters enter school, they meet children from diverse and unfamiliar backgrounds--regional, ethnic, religious, and racial. Often there is confusion, mistrust, and apprehension. In the eyes of a child, being different is not always a good thing. Parents and teachers bear the burden of discussing…

Brain volume reductions in adolescent heavy drinkers.

PubMed

Squeglia, Lindsay M; Rinker, Daniel A; Bartsch, Hauke; Castro, Norma; Chung, Yoonho; Dale, Anders M; Jernigan, Terry L; Tapert, Susan F

2014-07-01

Brain abnormalities in adolescent heavy drinkers may result from alcohol exposure, or stem from pre-existing neural features. This longitudinal morphometric study investigated 40 healthy adolescents, ages 12-17 at study entry, half of whom (n=20) initiated heavy drinking over the 3-year follow-up. Both assessments included high-resolution magnetic resonance imaging. FreeSurfer was used to segment brain volumes, which were measured longitudinally using the newly developed quantitative anatomic regional change analysis (QUARC) tool. At baseline, participants who later transitioned into heavy drinking showed smaller left cingulate, pars triangularis, and rostral anterior cingulate volume, and less right cerebellar white matter volumes (p<.05), compared to continuous non-using teens. Over time, participants who initiated heavy drinking showed significantly greater volume reduction in the left ventral diencephalon, left inferior and middle temporal gyrus, and left caudate and brain stem, compared to substance-naïve youth (p<.05). Findings suggest pre-existing volume differences in frontal brain regions in future drinkers and greater brain volume reduction in subcortical and temporal regions after alcohol use was initiated. This is consistent with literature showing pre-existing cognitive deficits on tasks recruited by frontal regions, as well as post-drinking consequences on brain regions involved in language and spatial tasks. Published by Elsevier Ltd.

Syntactic Processing in the Human Brain: What We Know, What We Don't Know, and a Suggestion for How to Proceed

ERIC Educational Resources Information Center

Fedorenko, Evelina; Nieto-Castanon, Alfonso; Kanwisher, Nancy

2012-01-01

For every claim in the neuroimaging literature about a particular brain region supporting syntactic processing, there exist other claims implicating the target region in different linguistic processes, and, in many cases, in non-linguistic cognitive processes (e.g., Blumstein, 2009). We argue that traditional group analysis methods in neuroimaging…

The costs of public primary health care services in rural Indonesia.

PubMed Central

Berman, P.; Brotowasisto; Nadjib, M.; Sakai, S.; Gani, A.

1989-01-01

Described are the results of a cost study of national rural health services carried out in Indonesia between November 1986 and March 1987. Detailed costings of government inputs to all public health services below the district hospital level were made for 41 subdistricts in five provinces that were representative of the different regions of the country. The total costs of services as well as the average costs for specific service functions were estimated for the whole country as well as for the different provinces. The results indicate a low overall level of government spending on rural primary health care. Regional differences in this respect were not significant, suggesting that the government policy of encouraging regional balance in allocations has been successful. The average costs for most services were much greater than the charges made to patients, and this provided information on the current level of government subsidies. There was a large variability in the average costs, indicating that the existing system is inefficient, that some districts were able to attain much higher levels of efficiency than others within the existing constraints, and that improvements in this respect are possible. PMID:2517412

A vast amount of various invariant tori in the Nosé-Hoover oscillator.

PubMed

Wang, Lei; Yang, Xiao-Song

2015-12-01

This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

Rethinking the solar flare paradigm

NASA Astrophysics Data System (ADS)

D, B. MELROSE

2018-07-01

It is widely accepted that solar flares involve release of magnetic energy stored in the solar corona above an active region, but existing models do not include the explicitly time-dependent electrodynamics needed to describe such energy release. A flare paradigm is discussed that includes the electromotive force (EMF) as the driver of the flare, and the flare-associated current that links different regions where magnetic reconnection, electron acceleration, the acceleration of mass motions and current closure occur. The EMF becomes localized across regions where energy conversion occurs, and is involved in energy propagation between these regions.

A vast amount of various invariant tori in the Nosé-Hoover oscillator

NASA Astrophysics Data System (ADS)

Wang, Lei; Yang, Xiao-Song

2015-12-01

This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

Inflammatory bowel disease in the Asia-Pacific area: a comparison with developed countries and regional differences.

PubMed

Ahuja, Vineet; Tandon, Rakesh K

2010-06-01

The Asia-Pacific region has been marked as an area with a low incidence of inflammatory bowel disease (IBD), although confusion always existed as to whether this low incidence was a result of low diagnostic awareness, a high incidence of infective diarrhoea and its diagnostic overlap or a true low incidence. As epidemiological studies from this region are being made available it is clear that the incidence and prevalence rates of IBD in Asia-Pacific region are low compared with Europe and North America. They are however, increasing rapidly. There are substantial variations in the incidence and prevalence rates of IBD in various ethnic groups in Asia. The highest incidence rates are recorded from India, Japan and the Middle East and there exists a genetic predisposition of South Asians (Indians, Pakistanis and Bangladeshis) to ulcerative colitis (UC). It appears that certain racial groups are more prone than others to develop IBD. For instance, Indians in South-East Asia have higher rates than Chinese and Malays. While there is a host genetic predisposition, environmental factor(s) may be responsible for this difference. The clinical phenotypes and complication rates of Asian IBD resemble those of the Caucasian population in general, but some heterogeneity is observed in different regions of Asia. There is no evidence of a north-south or an east-west divide in the Asia-Pacific region. The available studies suggest an increasing incidence of UC in the Asia-Pacific region and hence it is an appropriate time to launch well-designed epidemiological studies so that etiopathogenetic factors can be identified. There is a male predominance in Crohn's disease in the Asian population. The NOD2/CARD15 gene is not associated with CD in the Japanese, Korean, Chinese and Indian population.

Detecting technology of biophotons

NASA Astrophysics Data System (ADS)

Ma, Junfu; Zhu, Zhaohui; Zhu, Yanbin

2002-03-01

A key technique of detecting the ultra-weak photon emission from biological system (UPE) is to change the light signal of an extremely weak level into electric signal of a considerable level when the photo-electric detecting system were be applied. This paper analyzed the difficult for detecting the ultra-weak photon emission from biological system (UPE) mainly is in the absence of high sensitivity detector in UV-visible-infra spectra region. An experimental setup for testing UPE in different spectral region was designed. Using the experimental setup the test data of different several spectral regions from 300 nm to 1060 nm has were tested. The test result show the UPE of living biological system exists in wide spectra region from UV- visible to infrared.

The change in capacity and service delivery at public and private hospitals in Turkey: a closer look at regional differences.

PubMed

Aksan, Hediye A D; Ergin, Işıl; Ocek, Zeliha

2010-11-01

Substantial regional health inequalities have been shown to exist in Turkey for major health indicators. Turkish data on hospitals deserves a closer examination with a special emphasis on the regional differences in the context of the rapid privatization of the secondary or tertiary level health services.This study aims to evaluate the change in capacity and service delivery at public and private hospitals in Turkey between 2001-2006 and to determine the regional differences. Data for this retrospective study was provided from Statistical Almanacs of Inpatient Services (2001-2006). Hospitals in each of the 81 provinces were grouped into two categories: public and private. Provinces were grouped into six regions according to a development index composed by the State Planning Organisation. The number of facilities, hospital beds, outpatient admissions, inpatient admissions (per 100 000), number of deliveries and surgical operations (per 10 000) were calculated for public and private hospitals in each province and region. Regional comparisons were based on calculation of ratios for Region 1(R1) to Region 6(R6). Public facilities had a fundamental role in service delivery. However, private sector grew rapidly in Turkey between 2001-2006 in capacity and service delivery. In public sector, there were 2.3 fold increase in the number of beds in R1 to R6 in 2001. This ratio was 69.9 fold for private sector. The substantial regional inequalities in public and private sector decreased for the private sector enormously while a little decrease was observed for the public sector. In 2001 in R1, big surgical operations were performed six times more than R6 at the public sector whereas the difference was 117.7 fold for the same operations in the same regions for the private sector. These ratios decreased to 3.6 for the public sector and 13.9 for the private sector in 2006. The private health sector has grown enormously between 2001-2006 in Turkey including the less developed regions of the country. Given the fact that majority of people living in these underdeveloped regions are uninsured, the expansion of the private sector may not contribute in reducing the inequalities in access to health care. In fact, it may widen the existing gap for access to health between high and low income earners in these underdeveloped regions.

Conformation switching of AIM2 PYD domain revealed by NMR relaxation and MD simulation.

PubMed

Wang, Haobo; Yang, Lijiang; Niu, Xiaogang

2016-04-29

Protein absent in melanoma 2 (AIM2) is a double-strand DNA (ds DNA) sensor mainly located in cytoplasm of cell. It includes one N terminal PYD domain and one C terminal HIN domain. When the ds DNA such as DNA viruses and bacteria entered cytoplasm, the HIN domain of AIM2 will recognize and bind to DNA, and the PYD domain will bind to ASC protein which will result in the formation of AIM2 inflammasome. Three AIM2 PYD domain structures have been solved, but every structure yields a unique conformation around the α3 helix region. To understand why different AIM2 PYD structures show different conformations in this region, we use NMR relaxation techniques to study the backbone dynamics of mouse AIM2 PYD domain and perform molecular dynamics (MD) simulations on both mouse and human AIM2 PYD structures. Our results indicate that this region is highly flexible in both mouse and human AIM2 PYD domains, and the PYD domain may exist as a conformation ensemble in solution. Different environment makes the population vary among pre-existing conformational substrates of the ensemble, which may be the reason why different AIM2 PYD structures were observed under different conditions. Further docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein. Copyright © 2016 Elsevier Inc. All rights reserved.

Disparities in medication therapy in patients with heart failure across the State of Hawai'i.

PubMed

Goo, Roy Alan; Ma, Carolyn; Juarez, Deborah Taira

2015-01-01

The purpose of this study is to evaluate if heart failure patients in Hawai'i are receiving recommended standard therapy of a select beta-blocker in combination with an ACE inhibitor (ACEI) or angiotensin receptor blocker (ARB), and to determine if a gap in quality of care exists between the different regions within the state. A retrospective claims-based analysis of all adult patients (age > 18 years of age) with CHF who were enrolled in a large health plan in Hawai'i was performed (n = 24,149). Data collected included the presence of pharmaceutical claims for ACEI, ARBs and select β-blockers, region of residence, gender, and age. Multivariable logistic regression was used to examine whether there were regional differences in Hawai'i related to medication usage, after adjustment for age and gender. Results showed that only 28.4 % of patients were placed on the recommended therapy of an ACEI or ARB and a select β-blocker with significant differences being found between different regions. Further research is needed to better understand factors affecting regional differences in prescribing patterns.

Differences in STEM degree attainment by region, ethnicity, and degree type

NASA Astrophysics Data System (ADS)

Koledoye, Kimberly A.

Purpose One purpose of this study was to determine the extent to which a difference was present in the STEM degree attainment of all students and particularly of URMs between the 2001 and the 2009 academic year. The second purpose of this study was to determine the extent to which a difference was present in the attainment of STEM associate degrees and bachelor degrees of all students and particularly of URMs awarded between the 2001 and the 2009 academic year. Another purpose of this study was to determine the extent to which a difference existed in STEM associate degree and STEM bachelor degree attainment among geographic regions between the 2001 and the 2009 academic years. The extent to which a difference existed in the STEM bachelor degree and associate degree attainment of URMs among geographic regions between the 2001 to the 2009 academic year was ascertained. The final purpose of this study was to determine the extent to which a difference was present in STEM associate degree and bachelor degree attainment of all students and particularly URMs as a function of degree type between the 2001 academic year and the 2009 academic year. Methodology Archival data from the Integrated Postsecondary Education Data System were utilized to compare STEM degree attainment for regions, regions for URMs, STEM degree attainment overall and for URMs, STEM degree attainment classified by associate degrees and bachelor degrees for all students and URMs, and STEM degree attainment of associate degrees and bachelor degrees for all students and URMs by specific degree type between 2001 and 2009. Findings In this non-experimental causal comparative investigation, statistically significant differences were revealed in 95 of the 165 comparisons. Declining associate degree attainment was concerning, particularly in the computer and information sciences and engineering and engineering technologies. Moderate increases were determined in bachelor degree attainment with statistically significant differences identified in all STEM degree areas. Women had more increases than other URMs, and degree attainment by geographic region varied widely. Given the strong national need for more STEM graduates, reason for concerns are raised by the results of this investigation. KEY WORDS: STEM degrees, Associate, Bachelor, IPEDS

Empirical Study on Total Factor Productive Energy Efficiency in Beijing-Tianjin-Hebei Region-Analysis based on Malmquist Index and Window Model

NASA Astrophysics Data System (ADS)

Xu, Qiang; Ding, Shuai; An, Jingwen

2017-12-01

This paper studies the energy efficiency of Beijing-Tianjin-Hebei region and to finds out the trend of energy efficiency in order to improve the economic development quality of Beijing-Tianjin-Hebei region. Based on Malmquist index and window analysis model, this paper estimates the total factor energy efficiency in Beijing-Tianjin-Hebei region empirically by using panel data in this region from 1991 to 2014, and provides the corresponding political recommendations. The empirical result shows that, the total factor energy efficiency in Beijing-Tianjin-Hebei region increased from 1991 to 2014, mainly relies on advances in energy technology or innovation, and obvious regional differences in energy efficiency to exist. Throughout the window period of 24 years, the regional differences of energy efficiency in Beijing-Tianjin-Hebei region shrank. There has been significant convergent trend in energy efficiency after 2000, mainly depends on the diffusion and spillover of energy technologies.

Heterogeneity of spine density in pyramidal neurons of isocortex of mongoose, Herpestes edwardsii (É. Geoffroy Saint-Hilaire 1818).

PubMed

Srivastava, U C; Singh, Sippy; Chauhan, Prashant

2013-08-01

The characteristics of pyramidal neurons within six layers of Indian gray mongoose (Herpestes edwardsii) isocortex have been investigated using Golgi and Cresyl-Violet methods. Pyramidal neurons and the cytoarchitecture of isocortex of mongoose were photographed with the help of computer aided Nikon eclipse 80i microscope whereas the lucida drawings were made by simple light microscope equipped with camera lucida. The cortical neurons exhibit marked regional differences in phenotype. The differences occur in morphology and distribution of spines within the cortical neurons not only among different species but also within an animal's brain. The present investigation aims at studying the features of pyramidal neurons and to find out the differences if any in distribution of spines in different layers (II-VI) as well as regions (Frontal, Temporal, Parietal, and Occipital) of isocortex of mongoose, which will provide information regarding importance of different layer and region. This piece of work embarks the findings that spine density shows inter-regional as well as interlaminar variations within isocortex of mongoose indicating that pyramidal cells present in varied layer and region are not equally functional and there do exists differences in activity among layers and regions. Among regions, the Temporal region possessing highest spine density contributes more toward functioning of mongoose isocortex and might play significant role in predatory nature of mongoose because this region in mammals is associated with auditory, visual perception, and object recognition. Copyright © 2013 Wiley Periodicals, Inc.

Telepsychiatry.

DTIC Science & Technology

1998-09-01

existing data sources. gathering end maintaning the date needed, end completing an reviewing the collection of information. Send comment regarding thie...Cooperative Agreement. The first phase of data collection included identifying the different regions and the relevant agencies and persons. Menninger...34 Menninger contacted commanders of 54 MTFs and interviewed 24 different commanders, lead agent staff, behavioral health consultants, and telepsychiatry

Florida Bay salinity and Everglades wetlands hydrology circa 1900 CE: A compilation of paleoecology-based statistical modeling analyses

USGS Publications Warehouse

Marshall, F.E.; Wingard, G.L.

2012-01-01

The upgraded method of coupled paleosalinity and hydrologic models was applied to the analysis of the circa-1900 CE segments of five estuarine sediment cores collected in Florida Bay. Comparisons of the observed mean stage (water level) data to the paleoecology-based model's averaged output show that the estimated stage in the Everglades wetlands was 0.3 to 1.6 feet higher at different locations. Observed mean flow data compared to the paleoecology-based model output show an estimated flow into Shark River Slough at Tamiami Trail of 401 to 2,539 cubic feet per second (cfs) higher than existing flows, and at Taylor Slough Bridge an estimated flow of 48 to 218 cfs above existing flows. For salinity in Florida Bay, the difference between paleoecology-based and observed mean salinity varies across the bay, from an aggregated average salinity of 14.7 less than existing in the northeastern basin to 1.0 less than existing in the western basin near the transition into the Gulf of Mexico. When the salinity differences are compared by region, the difference between paleoecology-based conditions and existing conditions are spatially consistent.

Timing of chaotic terrain formation in Argadnel Regio, Europa, and implications for geological history

NASA Astrophysics Data System (ADS)

Parro, Laura M.; Ruiz, Javier; Pappalardo, Robert T.

2016-10-01

Chaos terrains are among the most prominent landforms of Europa, and are generally among the youngest features recorded on the surface. Chaos units were formed by to endogenic activity, maybe related to solid-state convection and thermal diapirism in the ice shell, perhaps aided by melting of salt-rich ice bodies below the surface. In this work, we analyze the different units of chaotic terrain in a portion of Argadnel Regio, a region located on the anti-Jovian hemisphere of Europa, and their possible timing in the general stratigraphic framework of this satellite. Two different chaos units can be differentiated, based on surface texture, morphology, and cross-cutting relationships with other units, and from interpretations based on pre-existing surface restoration through elimination of a low albedo band. The existence of two stratigraphically different chaos units implies that conditions for chaos formation occurred during more than a single discreet time on Europa, at least in Argadnel Regio, and perhaps in other places. The existence of older chaos units on Europa might be related to convective episodes possibly favored by local conditions in the icy shell, such as variations in grain size, abundance of non-water ice-components, or regional thickness of the brittle lithosphere or the entire ice shell.

Evaluation of the Effectiveness of Stormwater Decision Support Tools for Infrastructure Selection and the Barriers to Implementation

NASA Astrophysics Data System (ADS)

Spahr, K.; Hogue, T. S.

2016-12-01

Selecting the most appropriate green, gray, and / or hybrid system for stormwater treatment and conveyance can prove challenging to decision markers across all scales, from site managers to large municipalities. To help streamline the selection process, a multi-disciplinary team of academics and professionals is developing an industry standard for selecting and evaluating the most appropriate stormwater management technology for different regions. To make the tool more robust and comprehensive, life-cycle cost assessment and optimization modules will be included to evaluate non-monetized and ecosystem benefits of selected technologies. Initial work includes surveying advisory board members based in cities that use existing decision support tools in their infrastructure planning process. These surveys will qualify the decisions currently being made and identify challenges within the current planning process across a range of hydroclimatic regions and city size. Analysis of social and other non-technical barriers to adoption of the existing tools is also being performed, with identification of regional differences and institutional challenges. Surveys will also gage the regional appropriateness of certain stormwater technologies based off experiences in implementing stormwater treatment and conveyance plans. In additional to compiling qualitative data on existing decision support tools, a technical review of components of the decision support tool used will be performed. Gaps in each tool's analysis, like the lack of certain critical functionalities, will be identified and ease of use will be evaluated. Conclusions drawn from both the qualitative and quantitative analyses will be used to inform the development of the new decision support tool and its eventual dissemination.

Are there cross-cultural differences of ADL ability in children measured with the Assessment of Motor and Process Skills (AMPS)?

PubMed

Peny-Dahlstrand, Marie; Gosman-Hedström, Gunilla; Krumlinde-Sundholm, Lena

2012-01-01

In many studies of self-care assessments for children, cultural differences in age-norm values have been shown. No study has evaluated whether there are cross-cultural differences in ADL motor and/or process skills in children when measured with the Assessment of Motor and Process Skills (AMPS). To investigate if there were systematic differences in ADL ability measured with the AMPS between children from the Nordic countries and North America and to evaluate the applicability of the existing international age-normative values for children from these two regions. Values from a total of 4 613 children, 3-15 years old, without known disabilities, from these geographical regions were compared with ANOVA. The difference in logits between each region and the mean values for each age group were calculated. No differences of relevance in age-related ADL ability measures between children from the two geographical regions were found, and the age-norm values are applicable to both regions. The AMPS may be considered free from cultural bias and useful in both clinical practice and research concerned with children in both the Nordic countries and North America.

The 5th national survey on the physical growth and development of children in the nine cities of China: Anthropometric measurements of Chinese children under 7 years in 2015.

PubMed

Zhang, Ya-Qin; Li, Hui; Wu, Hua-Hong; Zong, Xin-Nan; Zhu, Zong-Han; Pan, Ying; Li, Jia; Zheng, Xing-Rong; Wei, Mei; Tong, Mei-Ling; Zhou, Ai-Fen; Hu, Yan; Chen, Wei; Zhu, Ke; Yu, Yang

2017-07-01

To describe the physical growth of healthy children under 7 years in China based on the latest national survey and provide more data for revising growth reference and monitoring the impact of social development on children's health and growth. In the cross-sectional survey, 161,774 healthy children under 7 years were selected by multistage stratified cluster sampling method in nine cities of China. According to the geographical location, the nine cities were divided into northern, central and southern regions, and each city included urban and suburban areas. Anthropometric measurements were obtained on the spots and other related information was collected with questionnaires. There were slight urban-suburban difference and obvious regional difference in anthropometric measurements in China. Comparison with the 4th NSPGDC in 2005, measurements increased 0.1-1.1 kg in weight, 0.5-1.8 cm in height in urban areas (except children under 3 years) and 0.1-2.5 kg in weight, 0.2-3.8 cm in height in suburban areas. The urban-suburban difference of those measurements became smaller than 10 years ago, but their regional difference persistently exist. Chinese children were 0.36 SD in weight, 0.43 SD in height in urban areas and 0.30 SD in weight, 0.30 SD in height in suburban areas higher than WHO standards. Physical growth of children under 7 years old was undergoing a slowly positive secular trend during the latest decade in more economically developed regions of China. Urban-suburban difference of those measurements became smaller, while their regional difference persistently exist. Chinese healthy children under 7 years in nine cities was taller and heavier than WHO standards. © 2017 Wiley Periodicals, Inc.

P-wave tomography of the Chile Triple Junction region

NASA Astrophysics Data System (ADS)

Miller, M. R.; Priestley, K. F.; Tilmann, F. J.; Iwamori, H.; Bataille, K.

2010-12-01

We investigate the crustal and upper mantle structure of the Aysén region of Chile. This region is situated from 44 to 49oS, a place where the diverging oceanic Nazca and Antarctic plates subduct beneath the South American continent. The Seismic Experiment in the Aysén Region of CHile (SEARCH) project operated a network of up to 60 land-based seismometers in this region between 2004 and 2006, centred over a 6 Ma subducted spreading centre between the oceanic plates. The data is used to examine the P-wave velocity structure beneath the region using relative-arrival teleseismic travel time tomography, using 2534 P-wave residuals from 173 teleseismic earthquakes. It is possible to image the velocity structure beneath the seismic network down to ˜300 km depth. The velocity structure has a maximum resolution of ˜60 km and shows a large difference between the northern and southern parts of the region. To the north, a ˜100 km thick fast anomaly exists which dips away from the subduction trench; this is likely to be related to the subducting Nazca plate. Going to the south, as the age of this plate at the subduction trench decreases, the fast anomaly migrates further from the trench suggesting that the Nazca plate subducts at a low angle over a larger distance before the subduction angle steepens and hence slab tears exist across the fracture zones between parts of the slab of different age. Where the 6 Ma subducted ridge segment is predicted to lie there is a region of lower velocities between ˜200 and ˜100 km depth, and no fast region associated with a subducting slab is present. Instead, the lower velocities indicate the presence of an asthenospheric window between the subducted Nazca and Antarctic plate.

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer.

PubMed

Liu, Mingshan; Liu, Yang; Di, Jiabo; Su, Zhe; Yang, Hong; Jiang, Beihai; Wang, Zaozao; Zhuang, Meng; Bai, Fan; Su, Xiangqian

2017-11-23

Colorectal cancer is a heterogeneous group of malignancies with complex molecular subtypes. While colon cancer has been widely investigated, studies on rectal cancer are very limited. Here, we performed multi-region whole-exome sequencing and single-cell whole-genome sequencing to examine the genomic intratumor heterogeneity (ITH) of rectal tumors. We sequenced nine tumor regions and 88 single cells from two rectal cancer patients with tumors of the same molecular classification and characterized their mutation profiles and somatic copy number alterations (SCNAs) at the multi-region and the single-cell levels. A variable extent of genomic heterogeneity was observed between the two patients, and the degree of ITH increased when analyzed on the single-cell level. We found that major SCNAs were early events in cancer development and inherited steadily. Single-cell sequencing revealed mutations and SCNAs which were hidden in bulk sequencing. In summary, we studied the ITH of rectal cancer at regional and single-cell resolution and demonstrated that variable heterogeneity existed in two patients. The mutational scenarios and SCNA profiles of two patients with treatment naïve from the same molecular subtype are quite different. Our results suggest each tumor possesses its own architecture, which may result in different diagnosis, prognosis, and drug responses. Remarkable ITH exists in the two patients we have studied, providing a preliminary impression of ITH in rectal cancer.

Territorial characteristics of low frequency electrostatic fluctuations in a simple magnetized torus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaur, R.; Singh, R.; Sarada Sree, A.

2011-01-15

This paper presents an experimental investigation of turbulence in simple toroidal plasma devices without rotational transform. It is argued that Rayleigh-Taylor (flute interchange) mode may be one of the source mechanisms for the observed turbulence but is not sufficient to explain its observed global characteristics. Taking BETA device as an example, we show that pure Rayleigh-Taylor mode cannot explain (i) the observation of mode maximum at the location other than where density scale length is minimum, (ii) the comparable value of amplitude level of fluctuations in good curvature region, and (iii) the decrease in the mode amplitude with increasing magneticmore » field. Investigations have revealed that there exists not only poloidal plasma flow but also that it is sheared. Including this effect explains the first observation. However, modification brought about by velocity shear in the Rayleigh-Taylor mode still does not explain our second and third observations. We have taken an approach that since Rayleigh-Taylor is not excited in a good curvature region, it cannot be the source of turbulence there. Nor is it defensible to say that turbulence born in a bad curvature region is carried over through ExB rotation to the good curvature region. Consequently, we have invoked cross-field Simon-Hoh instability for this region. Experimental evidence supporting our proposal is presented. This paper concludes that toroidal devices have simultaneous existence of different self-consistent sources of turbulence in different regions of the device.« less

Dynamics in the Parameter Space of a Neuron Model

NASA Astrophysics Data System (ADS)

Paulo, C. Rech

2012-06-01

Some two-dimensional parameter-space diagrams are numerically obtained by considering the largest Lyapunov exponent for a four-dimensional thirteen-parameter Hindmarsh—Rose neuron model. Several different parameter planes are considered, and it is shown that depending on the combination of parameters, a typical scenario can be preserved: for some choice of two parameters, the parameter plane presents a comb-shaped chaotic region embedded in a large periodic region. It is also shown that there exist regions close to these comb-shaped chaotic regions, separated by the comb teeth, organizing themselves in period-adding bifurcation cascades.

On the Formation Mechanism of A Long-lived Polar Crown Cavity

NASA Astrophysics Data System (ADS)

Karna, Nishu; Pesnell, William D.; Zhang, Jie

2016-10-01

We report the study of the longest-lived polar crown cavity of Solar Cycle 24th observed in the year 2013 and propose a physical mechanism to explain the sustained existence. We used high temporal and spatial resolution observations from the Atmospheric Imaging Assembly (AIA) and the Helioseismic Magnetic Imager (HMI) instruments on board the Solar Dynamics Observatory (SDO) to explore the structure and evolution. We examined the circumpolar cavity in great detail from March 21, 2013, till October 31, 2013, while it existed for more than one year. Our study suggests two necessary conditions to form a long stable circumpolar cavity or any polar crown cavity. First, the underlying polarity inversion line (PIL) of the circumpolar cavity is formed between the trailing part of dozens of decayed active regions distributed in different longitudes and the unipolar magnetic field in the polar coronal hole. Second, the long life of the cavity is sustained by the continuing flux cancellation along the polarity inversion line. The flux is persistently transported toward the polar region through surface meridional flow and diffusion, which also leads to the shrinking of the polar coronal hole. Comparing with the existing theory of the formation of polarity inversion lines, we introduce a new category named as "Diffused trailing flux and polar coronal hole interaction region" to explain the polar crown cavity. The existence of such region also helps explain the process of polar reversal, which provides insight into the solar cycle.

Quantifying opening-mode fracture spatial organization in horizontal wellbore image logs, core and outcrop: Application to Upper Cretaceous Frontier Formation tight gas sandstones, USA

NASA Astrophysics Data System (ADS)

Li, J. Z.; Laubach, S. E.; Gale, J. F. W.; Marrett, R. A.

2018-03-01

The Upper Cretaceous Frontier Formation is a naturally fractured gas-producing sandstone in Wyoming. Regionally, random and statistically more clustered than random patterns exist in the same upper to lower shoreface depositional facies. East-west- and north-south-striking regional fractures sampled using image logs and cores from three horizontal wells exhibit clustered patterns, whereas data collected from east-west-striking fractures in outcrop have patterns that are indistinguishable from random. Image log data analyzed with the correlation count method shows clusters ∼35 m wide and spaced ∼50 to 90 m apart as well as clusters up to 12 m wide with periodic inter-cluster spacings. A hierarchy of cluster sizes exists; organization within clusters is likely fractal. These rocks have markedly different structural and burial histories, so regional differences in degree of clustering are unsurprising. Clustered patterns correspond to fractures having core quartz deposition contemporaneous with fracture opening, circumstances that some models suggest might affect spacing patterns by interfering with fracture growth. Our results show that quantifying and identifying patterns as statistically more or less clustered than random delineates differences in fracture patterns that are not otherwise apparent but that may influence gas and water production, and therefore may be economically important.

Field-aligned currents in the undisturbed polar ionosphere

NASA Astrophysics Data System (ADS)

Kroehl, H. W.

1989-09-01

Field-aligned currents, FAC's, which couple ionospheric currents at high latitudes with magnetospheric currents have become an essential cornerstone to our understanding of plasma dynamics in the polar region and in the earth's magnetosphere. Initial investigators of polar electrodynamics including the aurora were unable to distinguish between the ground magnetic signatures of a purely two-dimensional current and those from a three-dimensional current system, ergo many scientists ignored the possible existence of these vertical currents. However, data from magnetometers and electrostatic analyzers flown on low-altitude, polar-orbiting satellites proved beyond any reasonable doubt that field-aligned currents existed, and that different ionospheric regions were coupled to different magnetospheric regions which were dominated by different electrodynamic processes, e.g., magnetospheric convection electric fields, magnetospheric substorms and parallel electric fields. Therefore, to define the “undisturbed” polar ionosphere and its structure and dynamics, one needs to consider these electrodynamic processes, to select times for analysis when they are not strongly active and to remember that the polar ionosphere may be disturbed when the equatorial, mid-latitude and sub-auroral ionospheres are not. In this paper we will define the principle high-latitude current systems, describe the effects of FAC's associated with these systems, review techniques which would minimize these effects and present our description of the “undisturbed” polar ionosphere.

The American College of Surgeons Needs-Based Assessment of Trauma Systems: Estimates for the State of California.

PubMed

Uribe-Leitz, Tarsicio; Esquivel, Micaela M; Knowlton, Lisa M; Ciesla, David; Lin, Feng; Hsia, Renee Y; Spain, David A; Winchell, Robert J; Staudenmayer, Kristan L

2017-05-01

In 2015, the American College of Surgeons Committee on Trauma convened a consensus conference to develop the Needs-Based Assessment of Trauma Systems (NBATS) tool to assist in determining the number of trauma centers required for a region. We tested the performance of NBATS with respect to the optimal number of trauma centers needed by region in California. Trauma center data were obtained from the California Emergency Services Authority Information Systems (CEMSIS). Numbers of admitted trauma patients (ISS > 15) were obtained using statewide nonpublic admissions data from the California Office of Statewide Health Planning and Development (OSHPD), CEMSIS, and data from local emergency medical service agency (LEMSA) directors who agreed to participate in a telephone survey. Population estimates per county for 2014 were obtained from the U.S. Census. NBATS criteria used included population, transport time, community support, and number of discharges for severely injured patients (ISS > 15) at nontrauma centers and trauma centers. Estimates for the number of trauma centers per region were created for each of the three data sources and compared to the number of existing centers. A total of 62 state-designated trauma centers were identified for California: 13 (21%) Level I, 36 (58%) Level II, and 13 (11%) Level III. NBATS estimates for the total number of trauma centers in California were 27% to 47% lower compared to the number of trauma centers in existence, but this varied based on urban/rural status. NBATS estimates were lower than the current state in 70% of urban areas but were higher in almost 90% of rural areas. All data sources (OSHPD, CEMSIS, local data) produced similar results. Estimates from the NBATS tool are different from what is currently in existence in California, and differences exist based on whether the region is rural or urban. Findings from the current study can help inform future iterations of the NBATS tool. Economic, level V.

Comparison of Bruch's Membrane Opening Minimum Rim Width Among Those With Normal Ocular Health by Race.

PubMed

Rhodes, Lindsay A; Huisingh, Carrie E; Quinn, Adam E; McGwin, Gerald; LaRussa, Frank; Box, Daniel; Owsley, Cynthia; Girkin, Christopher A

2017-02-01

To examine if racial differences in Bruch's membrane opening minimum rim width (BMO-MRW) in spectral-domain optical coherence tomography (SDOCT) exist, specifically between people of African descent (AD) and European descent (ED) in normal ocular health. Cross-sectional study. Patients presenting for a comprehensive eye examination at retail-based primary eye clinics were enrolled based on ≥1 of the following at-risk criteria for glaucoma: AD aged ≥40 years, ED aged ≥50 years, diabetes, family history of glaucoma, and/or pre-existing diagnosis of glaucoma. Participants with normal optic nerves on examination received SDOCT of the optic nerve head (24 radial scans). Global and regional (temporal, superotemporal, inferotemporal, nasal, superonasal, and inferonasal) BMO-MRW were measured and compared by race using generalized estimating equations. Models were adjusted for age, sex, and BMO area. SDOCT scans from 269 eyes (148 participants) were included in the analysis. Mean global BMO-MRW declined as age increased. After adjusting for age, sex, and BMO area, there was not a statistically significant difference in mean global BMO-MRW by race (P = .60). Regionally, the mean BMO-MRW was lower in the crude model among AD eyes in the temporal, superotemporal, and nasal regions and higher in the inferotemporal, superonasal, and inferonasal regions. However, in the adjusted model, these differences were not statistically significant. BMO-MRW was not statistically different between those of AD and ED. Race-specific normative data may not be necessary for the deployment of BMO-MRW in AD patients. Copyright © 2016 Elsevier Inc. All rights reserved.

Non-equilibrium electron energy distributions in HII regions: Implications for abundance determinations

NASA Astrophysics Data System (ADS)

Dopita, Michael; Nicholls, David

2012-07-01

Although the analysis of HII region emission lines provides the main way of probing the chemical evolution of the universe throughout cosmic time, currently significant (factor of 2) discrepancies exist between the different methods (principally the strong line, electron temperature and recombination line methods) used to calibrate the cosmic chemical abundance scale. Although effects such as temperature fluctuations and geometrical effects have been invoked, these fail to explain the observations, particularly in the UV. Here we will show that there exists good grounds for supposing that the electrons in HII regions, as in other space plasmas, are not distributed according to a Boltzmann law. Rather, they follow a κ- distribution with κ ˜ 10. With this novel formulation, we can resolve the abundance discrepancies which have plagued this field for over three decades. Interestingly enough, the size of the correction in emission line strengths increases as we go into the UV.

Regional differences in unmet need for contraception in Kenya: insights from survey data.

PubMed

Wafula, Sam W

2015-10-14

Women are described as experiencing unmet need for contraception if they are fecund, sexually active and wish to postpone or limit childbearing but fail to use contraception to do so. The consequences of unmet need include unwanted pregnancy, induced abortions, school dropout due to pregnancy and premature maternal deaths. Global efforts aimed at addressing the adverse effects of unmet need abound. In Kenya, one in every four married women in the reproductive age bracket (15-49 years) has unmet need for contraception. Regional differences exist but the reasons behind these differences remain poorly understood. The purpose of this study was to examine the extent to which regional differentials in unmet need for contraception exists and to explain the regional differences in unmet need for contraception in Kenya. The paper used the Kenya Demographic and Health Survey (2008/09) data. Unmet need for contraception was measured based on the revised estimates contained in the survey. Summary statistics were used to show the percentage differences in the values of selected covariates across the high and low unmet need zones. The dependent variable had three categories: no unmet need, unmet need for spacing and unmet need for limiting births. The categorical nature of this dependent variable which is not ordered in any way lends itself to the use of multinomial logistic regression. The paper applied the seemingly unrelated estimation (suest) test to ascertain whether the covariate coefficients between the high and low unmet need zones were different. Stata Version 13.0 was used for analysis. The percentage values of the selected covariates of unmet need for contraception were much higher in the high unmet need zone as compared to those observed in the low unmet need zones. On the overall, 15.4 % of women in the high unmet need zone had unmet need to space their next birth as compared to 8.6 % of their counterparts. Likewise, the percentage of women who wanted to limit further births stood at 14.1 % among women residing in high unmet need zones while those in low unmet need zones had 10.5 %. Further analysis based on seemingly unrelated estimation found that in general, a comparison of the coefficients been the high and low unmet need regions were significantly different (p < 0.05). Evidence from the nationally representative KDHS 2008/09 shows that regional differentials in the covariates of unmet need for contraception exist. There is need to address religious inhibitions that stymie contraceptive uptake especially in the high unmet need regions. Efforts should promote maternal education and economically empower women in order to reinforce individual and contextual attitudes towards the benefits of contraception. The government should also establish social franchise programs to increase access to costly long acting and permanent methods of contraception to poor women.

Regional climate response collaboratives: Multi-institutional support for climate resilience

USGS Publications Warehouse

Averyt, Kristen; Derner, Justin D.; Dilling, Lisa; Guerrero, Rafael; Joyce, Linda A.; McNeeley, Shannon; McNie, Elizabeth; Morisette, Jeffrey T.; Ojima, Dennis; O'Malley, Robin; Peck, Dannele; Ray, Andrea J.; Reeves, Matt; Travis, William

2018-01-01

Federal investments by U.S. agencies to enhance climate resilience at regional scales grew over the past decade (2010s). To maximize efficiency and effectiveness in serving multiple sectors and scales, it has become critical to leverage existing agency-specific research, infrastructure, and capacity while avoiding redundancy. We discuss lessons learned from a multi-institutional “regional climate response collaborative” that comprises three different federally-supported climate service entities in the Rocky Mountain west and northern plains region. These lessons include leveraging different strengths of each partner, creating deliberate mechanisms to increase cross-entity communication and joint ownership of projects, and placing a common priority on stakeholder-relevant research and outcomes. We share the conditions that fostered successful collaboration, which can be transferred elsewhere, and suggest mechanisms for overcoming potential barriers. Synergies are essential for producing actionable research that informs climate-related decisions for stakeholders and ultimately enhances climate resilience at regional scales.

Molecular epidemiology of enterovirus 71 infection in the central region of Taiwan from 2002 to 2012.

PubMed

Wu, Wen-Hao; Kuo, Ta-Cheng; Lin, Yu-Ting; Huang, Szu-Wei; Liu, Hsin-Fu; Wang, John; Chen, Yi-Ming Arthur

2013-01-01

Enterovirus 71 (EV71), a causative agent of hand, foot, and mouth disease can be classified into three genotypes and many subtypes. The objectives of this study were to conduct a molecular epidemiological study of EV71 in the central region of Taiwan from 2002-2012 and to test the hypothesis that whether the alternative appearance of different EV71 subtypes in Taiwan is due to transmission from neighboring countries or from re-emergence of pre-existing local strains. We selected 174 EV71 isolates and used reverse transcription-polymerase chain reaction to amplify their VP1 region for DNA sequencing. Phylogenetic analyses were conducted using Neighbor-Joining, Maximum Likelihood and Bayesian methods. We found that the major subtypes of EV71 in Taiwan were B4 for 2002 epidemic, C4 for 2004-2005 epidemic, B5 for 2008-2009 epidemic, C4 for 2010 epidemic and B5 for 2011-2012 epidemic. Phylogenetic analysis demonstrated that the 2002 and 2008 epidemics were associated with EV71 from Malaysia and Singapore; while both 2010 and 2011-2012 epidemics originated from different regions of mainland China including Shanghai, Henan, Xiamen and Gong-Dong. Furthermore, minor strains have been identified in each epidemic and some of them were correlated with the subsequent outbreaks. Therefore, the EV71 infection in Taiwan may originate from pre-existing minor strains or from other regions in Asia including mainland China. In addition, 101 EV71 isolates were selected for the detection of new recombinant strains using the nucleotide sequences spanning the VP1-2A-2B region. No new recombinant strain was found. Analysis of clinical manifestations showed that patients infected with C4 had significantly higher rates of pharyngeal vesicles or ulcers than patients infected with B5. This is the first study demonstrating that different EV 71 genotypes may have different clinical manifestations and the association of EV71 infections between Taiwan and mainland China.

Regional differences of physical activity and sedentary behaviour in Swiss children are not explained by socio-demographics or the built environment.

PubMed

Bringolf-Isler, Bettina; Mäder, Urs; Dössegger, Alain; Hofmann, Heidi; Puder, Jardena J; Braun-Fahrländer, Charlotte; Kriemler, Susi

2015-03-01

We evaluated whether regional differences in physical activity (PA) and sedentary behaviour (SB) existed along language boundaries within Switzerland and whether potential differences would be explained by socio-demographics or environmental characteristics. We combined data of 611 children aged 4 to 7 years from four regional studies. PA and SB were assessed by accelerometers. Information about the socio-demographic background was obtained by questionnaires. Objective neighbourhood attributes could be linked to home addresses. Multivariate regression models were used to test associations between PA and SB and socio-demographic characteristics and neighbourhood attributes. Children from the German compared to the French-speaking region were more physically active and less sedentary (by 10-15 %, p < 0.01). Although German-speaking children lived in a more favourable environment and a higher socioeconomic neighbourhood (differences p < 0.001), these characteristics did not explain the differences in PA behaviour between French and German speaking. Factors related to the language region, which might be culturally rooted were among the strongest correlates of PA and SB among Swiss children, independent of individual, social and environmental factors.

Salient region detection by fusing bottom-up and top-down features extracted from a single image.

PubMed

Tian, Huawei; Fang, Yuming; Zhao, Yao; Lin, Weisi; Ni, Rongrong; Zhu, Zhenfeng

2014-10-01

Recently, some global contrast-based salient region detection models have been proposed based on only the low-level feature of color. It is necessary to consider both color and orientation features to overcome their limitations, and thus improve the performance of salient region detection for images with low-contrast in color and high-contrast in orientation. In addition, the existing fusion methods for different feature maps, like the simple averaging method and the selective method, are not effective sufficiently. To overcome these limitations of existing salient region detection models, we propose a novel salient region model based on the bottom-up and top-down mechanisms: the color contrast and orientation contrast are adopted to calculate the bottom-up feature maps, while the top-down cue of depth-from-focus from the same single image is used to guide the generation of final salient regions, since depth-from-focus reflects the photographer's preference and knowledge of the task. A more general and effective fusion method is designed to combine the bottom-up feature maps. According to the degree-of-scattering and eccentricities of feature maps, the proposed fusion method can assign adaptive weights to different feature maps to reflect the confidence level of each feature map. The depth-from-focus of the image as a significant top-down feature for visual attention in the image is used to guide the salient regions during the fusion process; with its aid, the proposed fusion method can filter out the background and highlight salient regions for the image. Experimental results show that the proposed model outperforms the state-of-the-art models on three public available data sets.

A vast amount of various invariant tori in the Nosé-Hoover oscillator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Lei; Department of Mathematics and Physics, Hefei University, Hefei 230601; Yang, Xiao-Song, E-mail: yangxs@hust.edu.cn

2015-12-15

This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of “chaotic region” and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a “chaotic sea” for the Nosé-Hoover oscillator.

The change in capacity and service delivery at public and private hospitals in Turkey: A closer look at regional differences

PubMed Central

2010-01-01

Background Substantial regional health inequalities have been shown to exist in Turkey for major health indicators. Turkish data on hospitals deserves a closer examination with a special emphasis on the regional differences in the context of the rapid privatization of the secondary or tertiary level health services. This study aims to evaluate the change in capacity and service delivery at public and private hospitals in Turkey between 2001-2006 and to determine the regional differences. Methods Data for this retrospective study was provided from Statistical Almanacs of Inpatient Services (2001-2006). Hospitals in each of the 81 provinces were grouped into two categories: public and private. Provinces were grouped into six regions according to a development index composed by the State Planning Organisation. The number of facilities, hospital beds, outpatient admissions, inpatient admissions (per 100 000), number of deliveries and surgical operations (per 10 000) were calculated for public and private hospitals in each province and region. Regional comparisons were based on calculation of ratios for Region 1(R1) to Region 6(R6). Results Public facilities had a fundamental role in service delivery. However, private sector grew rapidly in Turkey between 2001-2006 in capacity and service delivery. In public sector, there were 2.3 fold increase in the number of beds in R1 to R6 in 2001. This ratio was 69.9 fold for private sector. The substantial regional inequalities in public and private sector decreased for the private sector enormously while a little decrease was observed for the public sector. In 2001 in R1, big surgical operations were performed six times more than R6 at the public sector whereas the difference was 117.7 fold for the same operations in the same regions for the private sector. These ratios decreased to 3.6 for the public sector and 13.9 for the private sector in 2006. Conclusions The private health sector has grown enormously between 2001-2006 in Turkey including the less developed regions of the country. Given the fact that majority of people living in these underdeveloped regions are uninsured, the expansion of the private sector may not contribute in reducing the inequalities in access to health care. In fact, it may widen the existing gap for access to health between high and low income earners in these underdeveloped regions. PMID:21040539

The post-genomic era of biological network alignment.

PubMed

Faisal, Fazle E; Meng, Lei; Crawford, Joseph; Milenković, Tijana

2015-12-01

Biological network alignment aims to find regions of topological and functional (dis)similarities between molecular networks of different species. Then, network alignment can guide the transfer of biological knowledge from well-studied model species to less well-studied species between conserved (aligned) network regions, thus complementing valuable insights that have already been provided by genomic sequence alignment. Here, we review computational challenges behind the network alignment problem, existing approaches for solving the problem, ways of evaluating their alignment quality, and the approaches' biomedical applications. We discuss recent innovative efforts of improving the existing view of network alignment. We conclude with open research questions in comparative biological network research that could further our understanding of principles of life, evolution, disease, and therapeutics.

Age-related differences in regional brain volumes: A comparison of optimized voxel-based morphometry to manual volumetry

PubMed Central

Kennedy, Kristen M.; Erickson, Kirk I.; Rodrigue, Karen M.; Voss, Michelle W.; Colcombe, Stan J.; Kramer, Arthur F.; Acker, James D.; Raz, Naftali

2009-01-01

Regional manual volumetry is the gold standard of in vivo neuroanatomy, but is labor-intensive, can be imperfectly reliable, and allows for measuring limited number of regions. Voxel-based morphometry (VBM) has perfect repeatability and assesses local structure across the whole brain. However, its anatomic validity is unclear, and with its increasing popularity, a systematic comparison of VBM to manual volumetry is necessary. The few existing comparison studies are limited by small samples, qualitative comparisons, and limited selection and modest reliability of manual measures. Our goal was to overcome those limitations by quantitatively comparing optimized VBM findings with highly reliable multiple regional measures in a large sample (N = 200) across a wide agespan (18–81). We report a complex pattern of similarities and differences. Peak values of VBM volume estimates (modulated density) produced stronger age differences and a different spatial distribution from manual measures. However, when we aggregated VBM-derived information across voxels contained in specific anatomically defined regions (masks), the patterns of age differences became more similar, although important discrepancies emerged. Notably, VBM revealed stronger age differences in the regions bordering CSF and white matter areas prone to leukoaraiosis, and VBM was more likely to report nonlinearities in age-volume relationships. In the white matter regions, manual measures showed stronger negative associations with age than the corresponding VBM-based masks. We conclude that VBM provides realistic estimates of age differences in the regional gray matter only when applied to anatomically defined regions, but overestimates effects when individual peaks are interpreted. It may be beneficial to use VBM as a first-pass strategy, followed by manual measurement of anatomically-defined regions. PMID:18276037

Chimeralike states in two distinct groups of identical populations of coupled Stuart-Landau oscillators

NASA Astrophysics Data System (ADS)

Premalatha, K.; Chandrasekar, V. K.; Senthilvelan, M.; Lakshmanan, M.

2017-02-01

We show the existence of chimeralike states in two distinct groups of identical populations of globally coupled Stuart-Landau oscillators. The existence of chimeralike states occurs only for a small range of frequency difference between the two populations, and these states disappear for an increase of mismatch between the frequencies. Here the chimeralike states are characterized by the synchronized oscillations in one population and desynchronized oscillations in another population. We also find that such states observed in two distinct groups of identical populations of nonlocally coupled oscillators are different from the above case in which coexisting domains of synchronized and desynchronized oscillations are observed in one population and the second population exhibits synchronized oscillations for spatially prepared initial conditions. Perturbation from such spatially prepared initial condition leads to the existence of imperfectly synchronized states. An imperfectly synchronized state represents the existence of solitary oscillators which escape from the synchronized group in population I and synchronized oscillations in population II. Also the existence of chimera state is independent of the increase of frequency mismatch between the populations. We also find the coexistence of different dynamical states with respect to different initial conditions, which causes multistability in the globally coupled system. In the case of nonlocal coupling, the system does not show multistability except in the cluster state region.

Regional inequalities in self-rated health and disability in younger and older generations in Turkey: the contribution of wealth and education.

PubMed

Ergin, Isil; Kunst, Anton E

2015-09-29

In Turkey, large regional inequalities were found in maternal and child health. Yet, evidence on regional inequalities in adult health in Turkey remains fragmentary. This study aims to assess regional and rural/urban inequalities in the prevalence of poor self-rated health and in disability among adult populations in Turkey, and to measure the contribution of education and wealth of individual residents. The central hypothesis was that geographical inequalities in adult health exist even when the effect of education and wealth were taken into account. We analyzed data of the 2002 World Health Survey for Turkey on 10791 adults aged 20 years and over. We measured respondents' rating of their own general health and the prevalence of five types of physical disability. Logistic regression was used to estimate how much these two health outcomes varied according to urban/rural place of residence, region, education level and household wealth. We stratified the analyses by gender and age (‹50 and ≥50 years). Both health outcomes were strongly associated with educational level (especially for older age group) and with household wealth (especially for younger age group). Both health outcomes also varied according to region and rural/urban place of residence. Higher prevalence rates were observed in the East region (compared to West) with odd ratios varying between 1.40-2.76. After controlling for education and wealth, urban/rural differences in health disappeared, while regional differences were observed only among older women. The prevalence of poor self-rated health was higher for older women in the Middle (OR = 1.69), Black Sea (OR = 1.53) and East (OR = 2.06) regions. In Turkey, substantial geographical inequalities in self-reported adult health do exist, but can mostly be explained by differences in socioeconomic characteristics of residents. The regional disadvantage of older women in the East, Middle and Black Sea may have resulted from life-long exposure to gender discrimination under a patriarchal ideology. Yet, not geographic inequalities, but the more fundamental socioeconomic inequalities, are of key public health concern, also in Turkey.

Understanding the Epidemiology of Heart Failure to Improve Management Practices: An Asia-Pacific Perspective.

PubMed

Rajadurai, Jeyamalar; Tse, Hung-Fat; Wang, Chao-Hung; Yang, Ning-I; Zhou, Jingmin; Sim, David

2017-04-01

Heart failure (HF) is a major global healthcare problem with an estimated prevalence of approximately 26 million. In Asia-Pacific regions, HF is associated with a significant socioeconomic burden and high rates of hospital admission. Epidemiological data that could help to improve management approaches to address this burden in Asia-Pacific regions are limited, but suggest patients with HF in the Asia-Pacific are younger and have more severe signs and symptoms of HF than those of Western countries. However, local guidelines are based largely on the European Society of Cardiology and American College of Cardiology Foundation/American Heart Association guidelines, which draw their evidence from studies where Western patients form the major demographic and patients from the Asia-Pacific region are underrepresented. Furthermore, regional differences in treatment practices likely affect patient outcomes. In the following review, we examine epidemiological data from existing regional registries, which indicate that these patients represent a distinct subpopulation of patients with HF. In addition, we highlight that patients with HF are under-treated in the region despite the existence of local guidelines. Finally, we provide suggestions on how data can be enriched throughout the region, which may positively affect local guidelines and improve management practices. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

OUTFLOWS AND DARK BANDS AT ARCADE-LIKE ACTIVE REGION CORE BOUNDARIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott, J. T.; Martens, P. C. H.; Tarr, L.

Observations from the EUV Imaging Spectrometer (EIS) on board Hinode have revealed outflows and non-thermal line broadening in low intensity regions at the edges of active regions (ARs). We use data from Hinode's EIS, Solar Dynamic Observatory's Atmospheric Imaging Assembly and Helioseismic and Magnetic Imager, and the Transition Region and Coronal Explorer instrument to investigate the boundaries of arcade-like AR cores for NOAA ARs 11112, 10978, and 9077. A narrow, low intensity region that is observed at the core's periphery as a dark band shows outflows and increased spectral line broadening. This dark band is found to exist for daysmore » and appears between the bright coronal loop structures of different coronal topologies. We find a case where the dark band region is formed between the magnetic field from emerging flux and the field of the pre-existing flux. A magnetic field extrapolation indicates that this dark band is coincident with the spine lines or magnetic separatrices in the extrapolated field. This occurs over unipolar regions where the brightened coronal field is separated in connectivity and topology. This separation does not appear to be infinitesimal and an initial estimate of the minimum distance of separation is found to be Almost-Equal-To 1.5-3.5 Mm.« less

A Comparison of the Scalar and Vorticity Criterion defining the T/NT Interface

NASA Astrophysics Data System (ADS)

Boschung, Jonas; Hennig, Fabian; Peters, Norbert

2013-11-01

Free shear flows are characterized by a turbulent core region, a non-turbulent outer flow and a turbulent/non-turbulent interface separating the two zones. While there exist different approaches to identify this transitional region, the interface position is mostly defined to coincide with the isoscalar surfaces of either a passive scalar or the magnitude of the vorticity. Both criteria are examined and compared using a shear layer DNS.

Patterns of Eye Movements When Observers Judge Female Facial Attractiveness

PubMed Central

Zhang, Yan; Wang, Xiaoying; Wang, Juan; Zhang, Lili; Xiang, Yu

2017-01-01

The purpose of the present study is to explore the fixed model for the explicit judgments of attractiveness and infer which features are important to judge the facial attractiveness. Behavioral studies on the perceptual cues for female facial attractiveness implied three potentially important features: averageness, symmetry, and sexual dimorphy. However, these studies did not explained which regions of facial images influence the judgments of attractiveness. Therefore, the present research recorded the eye movements of 24 male participants and 19 female participants as they rated a series of 30 photographs of female facial attractiveness. Results demonstrated the following: (1) Fixation is longer and more frequent on the noses of female faces than on their eyes and mouths (no difference exists between the eyes and the mouth); (2) The average pupil diameter at the nose region is bigger than that at the eyes and mouth (no difference exists between the eyes and the mouth); (3) the number of fixations of male participants was significantly more than female participants. (4) Observers first fixate on the eyes and mouth (no difference exists between the eyes and the mouth) before fixating on the nose area. In general, participants attend predominantly to the nose to form attractiveness judgments. The results of this study add a new dimension to the existing literature on judgment of facial attractiveness. The major contribution of the present study is the finding that the area of the nose is vital in the judgment of facial attractiveness. This finding establish a contribution of partial processing on female facial attractiveness judgments during eye-tracking. PMID:29209242

Patterns of Eye Movements When Observers Judge Female Facial Attractiveness.

PubMed

Zhang, Yan; Wang, Xiaoying; Wang, Juan; Zhang, Lili; Xiang, Yu

2017-01-01

The purpose of the present study is to explore the fixed model for the explicit judgments of attractiveness and infer which features are important to judge the facial attractiveness. Behavioral studies on the perceptual cues for female facial attractiveness implied three potentially important features: averageness, symmetry, and sexual dimorphy. However, these studies did not explained which regions of facial images influence the judgments of attractiveness. Therefore, the present research recorded the eye movements of 24 male participants and 19 female participants as they rated a series of 30 photographs of female facial attractiveness. Results demonstrated the following: (1) Fixation is longer and more frequent on the noses of female faces than on their eyes and mouths (no difference exists between the eyes and the mouth); (2) The average pupil diameter at the nose region is bigger than that at the eyes and mouth (no difference exists between the eyes and the mouth); (3) the number of fixations of male participants was significantly more than female participants. (4) Observers first fixate on the eyes and mouth (no difference exists between the eyes and the mouth) before fixating on the nose area. In general, participants attend predominantly to the nose to form attractiveness judgments. The results of this study add a new dimension to the existing literature on judgment of facial attractiveness. The major contribution of the present study is the finding that the area of the nose is vital in the judgment of facial attractiveness. This finding establish a contribution of partial processing on female facial attractiveness judgments during eye-tracking.

Analysis of MAGSAT and surface data of the Indian region

NASA Technical Reports Server (NTRS)

Agarwal, G. C. (Principal Investigator)

1983-01-01

Techniques and significant results of an analysis of MAGSAT and surface data of the Indian region are described. Specific investigative tasks included: (1) use of the multilevel data at different altitudes to develop a model for variation of magnetic anomaly with altitude; (2) development of the regional model for the description of main geomagnetic field for the Indian sub-continent using MAGSAT and observatory data; (3) development of regional mathematical model of secular variations over the Indian sub-continent; and (4) downward continuation of the anomaly field obtained from MAGSAT and its combination with the existing observatory data to produce a regional anomaly map for elucidating tectonic features of the Indian sub-continent.

Comparing rainfall patterns between regions in Peninsular Malaysia via a functional data analysis technique

NASA Astrophysics Data System (ADS)

Suhaila, Jamaludin; Jemain, Abdul Aziz; Hamdan, Muhammad Fauzee; Wan Zin, Wan Zawiah

2011-12-01

SummaryNormally, rainfall data is collected on a daily, monthly or annual basis in the form of discrete observations. The aim of this study is to convert these rainfall values into a smooth curve or function which could be used to represent the continuous rainfall process at each region via a technique known as functional data analysis. Since rainfall data shows a periodic pattern in each region, the Fourier basis is introduced to capture these variations. Eleven basis functions with five harmonics are used to describe the unimodal rainfall pattern for stations in the East while five basis functions which represent two harmonics are needed to describe the rainfall pattern in the West. Based on the fitted smooth curve, the wet and dry periods as well as the maximum and minimum rainfall values could be determined. Different rainfall patterns are observed among the studied regions based on the smooth curve. Using the functional analysis of variance, the test results indicated that there exist significant differences in the functional means between each region. The largest differences in the functional means are found between the East and Northwest regions and these differences may probably be due to the effect of topography and, geographical location and are mostly influenced by the monsoons. Therefore, the same inputs or approaches might not be useful in modeling the hydrological process for different regions.

Coherent properties of ultraweak photon emission from biological system and its application in medicine

NASA Astrophysics Data System (ADS)

Zhu, Yanbin; Ma, Junfu; Guo, Zhouyi

2001-10-01

In the paper the research status and viewpoints about the coherent of the ultra-weak photon emission from biological system (UPE) were simply introduced. For proving the biophotons indeed have coherent from another side, an experimental setup for testing UPE in different spectral region was designed. Using the experimental setup the test data of different several spectral regions from 300nm to 1060nm has been got. These test results show that UPE of living biological system exists in wide spectra region from UV-visible to infrared. Using the test data, we also can obtain the important conclusion of UPE has coherence. In the end of this paper, the UPE's application in medicine was discussed.

Local Magnetic Measurements of Trapped Flux Through a Permanent Current Path in Graphite

NASA Astrophysics Data System (ADS)

Stiller, Markus; Esquinazi, Pablo D.; Quiquia, José Barzola; Precker, Christian E.

2018-04-01

Temperature- and field-dependent measurements of the electrical resistance of different natural graphite samples suggest the existence of superconductivity at room temperature in some regions of the samples. To verify whether dissipationless electrical currents are responsible for the trapped magnetic flux inferred from electrical resistance measurements, we localized them using magnetic force microscopy on a natural graphite sample in remanent state after applying a magnetic field. The obtained evidence indicates that at room temperature a permanent current flows at the border of the trapped flux region. The current path vanishes at the same transition temperature T_c≈ 370 K as the one obtained from electrical resistance measurements on the same sample. This sudden decrease in the phase is different from what is expected for a ferromagnetic material. Time-dependent measurements of the signal show the typical behavior of flux creep of a permanent current flowing in a superconductor. The overall results support the existence of room-temperature superconductivity at certain regions in the graphite structure and indicate that magnetic force microscopy is suitable to localize them. Magnetic coupling is excluded as origin of the observed phase signal.

csaw: a Bioconductor package for differential binding analysis of ChIP-seq data using sliding windows

PubMed Central

Lun, Aaron T.L.; Smyth, Gordon K.

2016-01-01

Chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq) is widely used to identify binding sites for a target protein in the genome. An important scientific application is to identify changes in protein binding between different treatment conditions, i.e. to detect differential binding. This can reveal potential mechanisms through which changes in binding may contribute to the treatment effect. The csaw package provides a framework for the de novo detection of differentially bound genomic regions. It uses a window-based strategy to summarize read counts across the genome. It exploits existing statistical software to test for significant differences in each window. Finally, it clusters windows into regions for output and controls the false discovery rate properly over all detected regions. The csaw package can handle arbitrarily complex experimental designs involving biological replicates. It can be applied to both transcription factor and histone mark datasets, and, more generally, to any type of sequencing data measuring genomic coverage. csaw performs favorably against existing methods for de novo DB analyses on both simulated and real data. csaw is implemented as a R software package and is freely available from the open-source Bioconductor project. PMID:26578583

New longitudinal mode and compression of pair ions in plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ehsan, Zahida; Imran, Muhammad, E-mail: imransindhu@hotmail.com; Tsintsadze, N. L.

Positive and negative ions forming the so-called pair plasma differing in sign of their charge but asymmetric in mass and temperature support a new acoustic-like mode. The condition for the excitation of ion sound wave through electron beam induced Cherenkov instability is also investigated. This beam can generate a perturbation in the pair ion plasmas in the presence of electrons when there is number density, temperature, and mass difference in the two species of ions. Basic emphasis is on the focusing of ion sound waves, and we show how, in the area of localization of wave energy, the density ofmore » pair particles increases while electrons are pushed away from that region. Further, this localization of wave is dependent on the shape of the pulse. Considering the example of pancake and bullet shaped pulses, we find that only the former leads to compression of pair ions in the supersonic regime of the focusing region. Here, possible existence of regions where pure pair particles can exist may also be speculated which is not only useful from academic point of view but also to mimic the situation of plasma (electron positron asymmetric and symmetric) observed in astrophysical environment.« less

Blood flow occlusion-related O2 extraction "reserve" is present in different muscles of the quadriceps but greater in deeper regions after ramp-incremental test.

PubMed

Iannetta, Danilo; Okushima, Dai; Inglis, Erin Calaine; Kondo, Narihiko; Murias, Juan M; Koga, Shunsaku

2018-05-03

It was recently demonstrated that an O 2 extraction reserve, as assessed by the near-infrared spectroscopy (NIRS)-derived deoxygenation signal ([HHb]), exists in the superficial region of vastus lateralis (VL) muscle during an occlusion performed at the end of a ramp-incremental test. However, it is unknown whether this reserve is present and/or different in magnitude in other portions and depths of the quadriceps muscles. We tested the hypothesis that O 2 extraction would exist in other regions of this muscle but greater in deep compared to more superficial portions. Superficial and deep VL (VL-s and VL-d, respectively) as well as superficial rectus femoris (RF-s) were monitored by a combination of low- and high- power time resolved (TRS) NIRS. During the occlusion immediately post ramp-incremental test there was a significant overshoot in the [HHb] signal (P<0.05). However, the magnitude of this increase was greater in VL-d (93.2{plus minus}42.9%) compared to VL-s (55.0{plus minus}19.6%) and RF-s (47.8{plus minus}14.0%) (P<0.05). The present study demonstrated that an O2 extraction reserve exists in different pools of active muscle fibers of the quadriceps at the end of a ramp exercise to exhaustion. The greater magnitude in the reserve observed in the deeper portion of VL, however, suggests that this portion of muscle may present a greater surplus of oxygenated blood, likely due to a greater population of slow-twitch fibers. These findings add to the notion that the plateau in the [HHb] signal towards the end of a ramp-incremental exercise does not indicate the upper limit of O 2 extraction.

CH(+) Destruction by Reaction with H: Computing Quantum Rates To Model Different Molecular Regions in the Interstellar Medium.

PubMed

Bovino, S; Grassi, T; Gianturco, F A

2015-12-17

A detailed analysis of an ionic reaction that plays a crucial role in the carbon chemistry of the interstellar medium (ISM) is carried out by computing ab initio reactive cross sections with a quantum method and by further obtaining the corresponding CH(+) destruction rates over a range of temperatures that shows good overall agreement with existing experiments. The differences found between all existing calculations and the very-low-T experiments are discussed and explored via a simple numerical model that links these cross section reductions to collinear approaches where nonadiabatic crossing is expected to dominate. The new rates are further linked to a complex chemical network that models the evolution of the CH(+) abundance in the photodissociation region (PDR) and molecular cloud (MC) environments of the ISM. The abundances of CH(+) are given by numerical solutions of a large set of coupled, first-order kinetics equations that employs our new chemical package krome. The analysis that we carry out reveals that the important region for CH(+) destruction is that above 100 K, hence showing that, at least for this reaction, the differences with the existing laboratory low-T experiments are of essentially no importance within the astrochemical environments discussed here because, at those temperatures, other chemical processes involving the title molecule are taking over. A detailed analysis of the chemical network involving CH(+) also shows that a slight decrease in the initial oxygen abundance might lead to higher CH(+) abundances because the main chemical carbon ion destruction channel is reduced in efficiency. This might provide an alternative chemical route to understand the reason why general astrochemical models fail when the observed CH(+) abundances are matched with the outcomes of their calculations.

Existence Regions of Shock Wave Triple Configurations

ERIC Educational Resources Information Center

Bulat, Pavel V.; Chernyshev, Mikhail V.

2016-01-01

The aim of the research is to create the classification for shock wave triple configurations and their existence regions of various types: type 1, type 2, type 3. Analytical solutions for limit Mach numbers and passing shock intensity that define existence region of every type of triple configuration have been acquired. The ratios that conjugate…

The correlated network of acupuncture effect: a functional connectivity study.

PubMed

Qin, Wei; Tian, Jie; Pan, Xiaohong; Yang, Lin; Zhen, Zonglei

2006-01-01

A functional connectivity, which are temporally correlated in functionally related brain regions, before and after acupuncture manipulation was measured by MRI. Amygdala, as the control system of endogenetic analgesia, was selected for "seed" point. We found that compelling similarity existed in the network of resting state before and after acupuncture manipulation. A paired student t-test was implemented to investigate under the different conditions. The main difference was found in the limbic system, brainstem and cerebellum. We conclude that the default endogenous analgesia functional network exists in human brain at a low level, and it could be increased to a higher level by acupuncture modulation.

Carbon Nanotube Material Quality Assessment

NASA Technical Reports Server (NTRS)

Yowell, Leonard; Arepalli, Sivaram; Sosa, Edward; Niolaev, Pavel; Gorelik, Olga

2006-01-01

The nanomaterial activities at NASA Johnson Space Center focus on carbon nanotube production, characterization and their applications for aerospace systems. Single wall carbon nanotubes are produced by arc and laser methods. Characterization of the nanotube material is performed using the NASA JSC protocol developed by combining analytical techniques of SEM, TEM, UV-VIS-NIR absorption, Raman, and TGA. A possible addition of other techniques such as XPS, and ICP to the existing protocol will be discussed. Changes in the quality of the material collected in different regions of the arc and laser production chambers is assessed using the original JSC protocol. The observed variations indicate different growth conditions in different regions of the production chambers.

Land-use planning of Volyn region (Ukraine) using Geographic Information Systems (GIS) technologies

NASA Astrophysics Data System (ADS)

Strielko, Irina; Pereira, Paulo

2014-05-01

Land-use development planning is carried out in order to create a favourable environment for human life, sustainable socioeconomic and spatial development. Landscape planning is an important part of land-use development that aims to meet the fundamental principles of sustainable development. Geographic Information Systems (GIS) is a fundamental tool to make a better landscape planning at different territorial levels, providing data and maps to support decision making. The objective of this work is to create spatio-temporal, territorial and ecological model of development of Volyn region (Ukraine). It is based on existing spatial raster and vector data and includes the analysis of territory dynamics as the aspects responsible for it. A spatial analyst tool was used to zone the areas according to their environmental components and economic activity. This analysis is fundamental to define the basic parameters of sustainability of Volyn region. To carry out this analysis, we determined the demographic capacity of districts and the analysis of spatial parameters of land use. On the basis of the existing natural resources, we observed that there is a need of landscape protection and integration of more are natural areas in the Pan-European Ecological Network. Using GIS technologies to landscape planning in Volyn region, allowed us to identify, natural areas of interest, contribute to a better resource management and conflict resolution. Geographic Information Systems will help to formulate and implement landscape policies, reform the existing administrative system of Volyn region and contribute to a better sustainable development.

Aerodynamics and performance verifications of test methods for laboratory fume cupboards.

PubMed

Tseng, Li-Ching; Huang, Rong Fung; Chen, Chih-Chieh; Chang, Cheng-Ping

2007-03-01

The laser-light-sheet-assisted smoke flow visualization technique is performed on a full-size, transparent, commercial grade chemical fume cupboard to diagnose the flow characteristics and to verify the validity of several current containment test methods. The visualized flow patterns identify the recirculation areas that would inevitably exist in the conventional fume cupboards because of the fundamental configurations and structures. The large-scale vortex structures exist around the side walls, the doorsill of the cupboard and in the vicinity of the near-wake region of the manikin. The identified recirculation areas are taken as the 'dangerous' regions where the risk of turbulent dispersion of contaminants may be high. Several existing tracer gas containment test methods (BS 7258:1994, prEN 14175-3:2003 and ANSI/ASHRAE 110:1995) are conducted to verify the effectiveness of these methods in detecting the contaminant leakage. By comparing the results of the flow visualization and the tracer gas tests, it is found that the local recirculation regions are more prone to contaminant leakage because of the complex interaction between the shear layers and the smoke movement through the mechanism of turbulent dispersion. From the point of view of aerodynamics, the present study verifies that the methodology of the prEN 14175-3:2003 protocol can produce more reliable and consistent results because it is based on the region-by-region measurement and encompasses the most area of the entire recirculation zone of the cupboard. A modified test method combined with the region-by-region approach at the presence of the manikin shows substantially different results of the containment. A better performance test method which can describe an operator's exposure and the correlation between flow characteristics and the contaminant leakage properties is therefore suggested.

Social and economic consequences of onshore OCS-related activities in coastal Alabama: Final baseline report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kelley, J.O.; Wade, W.W.

This report documents existing economic conditions in the coastal Alabama region and highlights industry sectors important to the region`s economy. This report discusses the interplay among different users of the region`s natural resources, noting the tourism, fishing and offshore natural gas industries. Data are presented that show how the tourism and natural gas industries contribute to the economic growth of coastal Alabama and the State of Alabama. The recent conflict between the offshore gas and tourism industries over the use of coastal Alabama resources is discussed. Several case studies highlight local area experience relative to economic growth, industry coexistence andmore » the importance of the coastal region`s natural resources to the local and state economies.« less

[Functional analysis of Oct4 promoter in Xuhuai goat].

PubMed

Wei, Guanghui; Li, Dong; Zuo, Qisheng; Zhang, Yani; Zhu, Rui; Zhang, Lei; Liu, Zhiyong; Qiu, Fenglong; Li, Bichun

2014-08-01

The aim of this study was to determine the activity region of Oct4 (octamer-binding transcription factor 4) promoter in Xuhuai goat, and to investigate the effect of TSA (trichostatin A) and VPA(valproicacid) on Oct4 promoter activity. Specific PCR primers of Oct4 promoter including different lengths of fragments were designed by Primer 5.0, then were amplified and cloned into PGL3-Bacic luciferase reporter vector. All the reconstruction vectors were transfected into gEF, P19 and COS7 cells, respectively. After TSA and VPA treatment, the activity of dual-luciferase reporter gene in these three transfected cells was detected. In addition, the CMV promoter of pEGFP-N1 was replaced by the -1516─+30 bp fragment of Oct4 promoter, GFP fluorescence was used to detect the activity of Oct4 promoter. The results indicated that different fragments of Oct4 promoter showed different degrees of activity in gEF, P19 and COS7 cells, and the maximal activity region of Oct4 promoter was -1516─+30 bp, the basal activity region was -238─+30 bp. Positive regulatory domains existed in the region of -1516─-946 bp and -615─-96 bp, while negative regulatory domains existed in the region of -1936─-1516 bp and -946─-615 bp. The optimum induction concentration to enhance the activity of Oct4 promoter was 1 μmol/L of TSA and 4 mmol/L of VPA. The GFP expression can be started by the fragment of -1516─+30 bp. This study provides an experimental basis for revealing the mechanism of expression and regulation of Oct4 in goat.

The evaluation of the earthquake hazard using the exponential distribution method for different seismic source regions in and around Ağrı

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayrak, Yusuf, E-mail: ybayrak@agri.edu.tr; Türker, Tuğba, E-mail: tturker@ktu.edu.tr

The aim of this study; were determined of the earthquake hazard using the exponential distribution method for different seismic sources of the Ağrı and vicinity. A homogeneous earthquake catalog has been examined for 1900-2015 (the instrumental period) with 456 earthquake data for Ağrı and vicinity. Catalog; Bogazici University Kandilli Observatory and Earthquake Research Institute (Burke), National Earthquake Monitoring Center (NEMC), TUBITAK, TURKNET the International Seismological Center (ISC), Seismological Research Institute (IRIS) has been created using different catalogs like. Ağrı and vicinity are divided into 7 different seismic source regions with epicenter distribution of formed earthquakes in the instrumental period, focalmore » mechanism solutions, and existing tectonic structures. In the study, the average magnitude value are calculated according to the specified magnitude ranges for 7 different seismic source region. According to the estimated calculations for 7 different seismic source regions, the biggest difference corresponding with the classes of determined magnitudes between observed and expected cumulative probabilities are determined. The recurrence period and earthquake occurrence number per year are estimated of occurring earthquakes in the Ağrı and vicinity. As a result, 7 different seismic source regions are determined occurrence probabilities of an earthquake 3.2 magnitude, Region 1 was greater than 6.7 magnitude, Region 2 was greater than than 4.7 magnitude, Region 3 was greater than 5.2 magnitude, Region 4 was greater than 6.2 magnitude, Region 5 was greater than 5.7 magnitude, Region 6 was greater than 7.2 magnitude, Region 7 was greater than 6.2 magnitude. The highest observed magnitude 7 different seismic source regions of Ağrı and vicinity are estimated 7 magnitude in Region 6. Region 6 are determined according to determining magnitudes, occurrence years of earthquakes in the future years, respectively, 7.2 magnitude was in 158 years, 6.7 magnitude was in 70 years, 6.2 magnitude was in 31 years, 5.7 magnitude was in 13 years, 5.2 magnitude was in 6 years.« less

The evaluation of the earthquake hazard using the exponential distribution method for different seismic source regions in and around Aǧrı

NASA Astrophysics Data System (ADS)

Bayrak, Yusuf; Türker, Tuǧba

2016-04-01

The aim of this study; were determined of the earthquake hazard using the exponential distribution method for different seismic sources of the Aǧrı and vicinity. A homogeneous earthquake catalog has been examined for 1900-2015 (the instrumental period) with 456 earthquake data for Aǧrı and vicinity. Catalog; Bogazici University Kandilli Observatory and Earthquake Research Institute (Burke), National Earthquake Monitoring Center (NEMC), TUBITAK, TURKNET the International Seismological Center (ISC), Seismological Research Institute (IRIS) has been created using different catalogs like. Aǧrı and vicinity are divided into 7 different seismic source regions with epicenter distribution of formed earthquakes in the instrumental period, focal mechanism solutions, and existing tectonic structures. In the study, the average magnitude value are calculated according to the specified magnitude ranges for 7 different seismic source region. According to the estimated calculations for 7 different seismic source regions, the biggest difference corresponding with the classes of determined magnitudes between observed and expected cumulative probabilities are determined. The recurrence period and earthquake occurrence number per year are estimated of occurring earthquakes in the Aǧrı and vicinity. As a result, 7 different seismic source regions are determined occurrence probabilities of an earthquake 3.2 magnitude, Region 1 was greater than 6.7 magnitude, Region 2 was greater than than 4.7 magnitude, Region 3 was greater than 5.2 magnitude, Region 4 was greater than 6.2 magnitude, Region 5 was greater than 5.7 magnitude, Region 6 was greater than 7.2 magnitude, Region 7 was greater than 6.2 magnitude. The highest observed magnitude 7 different seismic source regions of Aǧrı and vicinity are estimated 7 magnitude in Region 6. Region 6 are determined according to determining magnitudes, occurrence years of earthquakes in the future years, respectively, 7.2 magnitude was in 158 years, 6.7 magnitude was in 70 years, 6.2 magnitude was in 31 years, 5.7 magnitude was in 13 years, 5.2 magnitude was in 6 years.

[Disparity on the grade of exposure to ecological risks in the European region of WHO].

PubMed

Braubach, M; Héroux, M E; Korol, N; Kosbaeva, A; Paunovic, E; Zastenskaia, I

2015-01-01

Disparity in relation of ecological conditions and health concerns to the general differences in environmental conditions and in large extent is stipulated by socio-economic and demographic differences in the impact of its hazards. In addition to differences in the impact the inequality in relation of ecological conditions and health can also be caused by social or demographic differences in exposure to certain risks. This article offers an assessment of the evidence and data on differences in the impact of the environment in the European Region of the World Health Organization (WHO) received during the recent work of the European Regional Office of WHO. The obtained results testify that socio-demographic disparity in the impact of the environment exists in all countries. Such inequality can be seen in respect of a variety offactors, such as age, gender income level, or on the contrary, poverty, education and employment, household type, location of the home.

Adaptation Strategies to Climate Change and the Role of Planning Instruments - The Example of the Dresden Region (Saxony/Germany)

NASA Astrophysics Data System (ADS)

Albrecht, J.; Juta, K.; Nobis, A.

2009-04-01

In the past, identifying anthropogenic influences on climate change, scenario analyses and issues of climate change mitigation were predominant approaches in climate change research (IPCC 2007). Currently, for instance in Germany, climate impact research on regional level comes to the forefront of research and policy making. Climate change has become an important topic on the agenda of politicians, administration and planning. In order to counteract the (unavoidable) climate change and its impacts it is necessary to develop adaptation strategies. At present, such strategies and guidelines are formulated on international, supranational and national level. The initial point was the United Nations Framework Convention on Climate Change in 1992 where the contracting states obligated themselves to develop national (and regional) programmes for adaptation. In 2007 the European Commission published its Green Paper called Adaptation to Climate Change in Europe. The paper states that adaptation efforts have to be intensified at different (spatial) levels (local, regional, national, and so forth). Furthermore, coordinating these efforts is of high importance. With the recent agreement on the German Adaptation Strategy to Climate Change (DAS 2008) in December 2008, federal government tries to accomplish this task. The German strategy mainly focuses on two elements: decreasing vulnerability and increasing adaptability. While the above mentioned strategies have presented information and policies concerning climate change and adaptation on international, supranational and national level, such documents dońt yet exist on regional level. However, because of their close link to the local level the regions are of high importance for adaptation strategies. Therefore, the Leibniz-Institute of Ecological and Regional Development developed a transdisciplinary project to formulate and implement the so-called Integrated Regional Climate Adaptation Programme (IRCAP) for the Model Region of Dresden (project REGKLAM). The REGKLAM-project is based on regionalised scenarios of climate change and includes measures of climate change adaptation to change for instance, urban form, infrastructure assets (e.g., reservoirs) and land use. Various institutions from politics, administration, economy, and research as well as civil society are involved in the project (the city of Dresden, several ministries and authorities of Saxony, the Dresden Chamber of Industry and Commerce and the University of Dresden). The IRCAP is planned to be an informal, cross-sectoral instrument of adaptation to climate change. As a regional programme, the IRCAP is addressed to decision-makers of the region of Dresden (defined, for instance, as planning region). Its function is to complement and coordinate existing instruments and measures. These instruments also include instruments of environmental and spatial planning on the regional level. Spatial and environmental planning can rely on a wide range of formal and informal instruments on different spatial, administrative, and sectoral levels, e.g. land use and landscape plans. Our contribution to the EGU conference aims to clear the role and relevance of the existing formal and informal planning instruments in the region of Dresden for the process of developing the IRCAP. Firstly, a survey is conducted for the purpose of identifying all relevant planning instruments. The identification process is based on specific criteria, for example: reference to the region, contents relating to the topic of climate change respectively climate adaptation. Secondly, the presentation argues for a selection of those planning instruments which seem to be most relevant for the process of developing an IRCAP. This selection process is based on specific criteria which include, for instance, complexity of expected effects, reference to regional and sectoral vulnerability, opportunity for future change of the existing planning instruments (e.g., current process of updating), interests of project partners and stakeholders. Thirdly, as a result, an overview of relevant planning instruments in the region of Dresden is shown, including their current status and statements about their relevance for the topic of climate adaptation strategies. Finally it is derived that this procedure provides a basis for the following possibilities: Adapting existing planning instruments, integrate contents of existing planning instruments in the IRCAP process, or develop and define new strategies or measures on the way to an IRCAP.

Exploring regional differences in the reading competencies of Italian students.

PubMed

Matteucci, Mariagiulia; Mignani, Stefania

2014-06-01

Recently, the study of territorial differences in educational outcomes has assumed a particular importance for the policy strategies related to the socioeconomic conditions of different geographical areas. In Italy, international surveys for student assessments have introduced a regional stratification only recently, and regular national student assessments started only in 2008. In this article, the reading performances of Italian students based on OECD-PISA 2009 are investigated, taking into account regional and macro-area partition. Student outcomes are explored by using a multilevel analysis, where school membership, socioeconomic and cultural background of students, and regional gross domestic product are introduced. The results show that, despite the existence of a unified educational system in Italy, regional and macro-area differences in student reading achievements are consolidated and variability in performances among schools is especially noticeable. Comparisons based on national assessments by INVALSI at the end of compulsory school confirm these findings. Italian policy makers are advised to take into account these results to improve learning opportunities and to reduce educational gaps. In particular, targeted regional policies are needed to improve the mean performance especially in the Southern regions of Calabria, Campania, and Sicilia, and to strengthen the system equity in several regions, such as Emilia-Romagna. To decrease the school differences, possible suggestions are to postpone the choice of the school type (currently, at age 14) and to motivate good teachers to work in schools located in the worst socioeconomic and cultural environments. © The Author(s) 2014.

Heterogeneous memory in restitution of action potential duration in pig ventricles.

PubMed

Jing, Linyuan; Chourasia, Sonam; Patwardhan, Abhijit

2010-01-01

Restitution of action potential duration and memory importantly affect electrical stability in ventricles. Studies have reported heterogeneous restitution among different regions of the ventricles. However, existence of heterogeneity in memory is not as well investigated. Transmembrane potentials were recorded in endocardial and epicardial tissues from both ventricles of farm pigs. Pacing protocols with sinusoidally changing diastolic intervals were used to reveal hysteresis in restitution, from which quantitative measures of memory were calculated. Larger measures of hysteresis were observed in the endocardium than the epicardium (P < .05): loop thickness (in milliseconds), 26.9 vs 16.2; overall tilt, 0.376 vs 0.249; and loop area (in square milliseconds), 7288 vs 4146. Except for overall tilt, no significant differences in these measures were observed between ventricles. Heterogeneity in memory exists in pig ventricles. Because regions with the steepest restitution may also have the largest memory, our results suggest that heterogeneity in memory should also be factored in when predicting electrical stability. Copyright 2010 Elsevier Inc. All rights reserved.

Pediatric Medicine Development: An Overview and Comparison of Regulatory Processes in the European Union and United States

PubMed Central

Penkov, Dobromir; Tomasi, Paolo; Eichler, Irmgard; Murphy, Dianne; Yao, Lynne P.; Temeck, Jean

2017-01-01

Pediatric legislation in the US and the EU is driving pediatric product development on an international scale. To facilitate harmonization and global development of pediatric medicines, it is important to understand the legislative requirements that must be met along with incentives that exist in the US and the EU to include pediatric patients in therapeutic clinical trials. Although there are many similarities, differences exist. This review is an effort to enhance understanding of the pediatric legislation in both regions. It is intended as an overview to supplement the region-specific legislation and guidance documents that are available on the websites of the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Despite differences, the goal of the legislation in both the EU and the US is to incentivize and require timely, ethical, and sound scientific development of pharmaceutical products for the pediatric population and to provide information for their safe and effective use. PMID:28674673

Microwave maps of the polar ice of the earth. [from Nimbus-5 satellite

NASA Technical Reports Server (NTRS)

Gloersen, P.; Wilheit, T. T.; Chang, T. C.; Nordberg, W.; Campbell, W. J.

1973-01-01

Synoptic views of the entire polar regions of earth were obtained free of the usual persistent cloud cover using a scanning microwave radiometer operating at a wavelength of 1.55 cm on board the Nimbus-5 satellite. Three different views at each pole are presented utilizing data obtained at approximately one-month intervals during the winter of 1972-1973. The major discoveries resulting from an analysis of these data are as follows: (1) Large discrepancies exist between the climatic norm ice cover depicted in various atlases and the actual extent of the canopies. (2) The distribution of multiyear ice in the north polar region is markedly different from that predicted by existing ice dynamics models. (3) Irregularities in the edge of the Antarctic sea ice pack occur that have neither been observed previously nor anticipated. (4) The brightness temperatures of the Greenland and Antarctica glaciers show interesting contours probably related to the ice and snow morphologic structure.

Regional variations in the management of testicular or ovotesticular disorders of sex development.

PubMed

Josso, N; Audi, L; Shaw, G

2011-01-01

Disorders of sex development arise in parts of the world with different socio-economic and cultural characteristics. We wished to determine the regional variations in the management of these conditions. A questionnaire was e-mailed to the 650 members of the European Society for Paediatric Endocrinology (ESPE), an international society with a mainly European membership but which also includes professionals from other continents. Results were subjected to statistical analysis. A total of 62 answers were received, a satisfactory rate given that not all members are involved in this issue. Results show statistically significant regional differences for available diagnostic resources, age of the patient at gender assignment, parameters considered important for gender assignment, and timing of discussion of various issues with parents and patient. The regional variations exist not only between different continents, as already demonstrated by others, but also between Northern, Latin and Eastern European countries. This suggests that 'one-fits-all' guidelines for management are not appropriate. Copyright © 2011 S. Karger AG, Basel.

Central Appalachia in advanced capitalism: its coal industry structure and coal operator associations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walls, D.S.

1978-01-01

This study traces the origins of the notion that Appalachia constitutes a unique social-problem region, examines the models of Appalachian problems popularized during the 1960s, proposes an alternative framework for situating the Central Appalachian coalfields, and examines aspects of the coal industry's structure in the Central Appalachian region. The idea of Appalachia as a distinctive social problem region was created between 1890 and 1930 by a social movement affiliated with various Protestant church home mission boards and organizationally focused in the Conference of Southern Mountain Workers and Berea College. The movement stressed an environmental explanation of regional problems. During themore » 1960s, three explanatory models of Appalachian poverty and underdevelopment achieved prominence: the subculture of poverty model, the regional development model, and the internal colonialism model. Each contributed to a regionalized conception of Appalachian problems. Empirical studies show the subculture of poverty model to fail as an explanation of regional underdevelopment. In the absence of a critique of domination and a redistribution of power and wealth, the regional development model serves as a rationalization of existing structures of privilege. The internal colonialism model provides a critique of domination, but not the most appropriate one. This study argues that the above models should not be viewed as mutually exclusive formulations, and that they may be reconstructed to represent different dimensions of social existence.« less

Regional endothermy as a trigger for gigantism in some extinct macropredatory sharks

PubMed Central

2017-01-01

Otodontids include some of the largest macropredatory sharks that ever lived, the most extreme case being Otodus (Megaselachus) megalodon. The reasons underlying their gigantism, distribution patterns and extinction have been classically linked with climatic factors and the evolution, radiation and migrations of cetaceans during the Paleogene. However, most of these previous proposals are based on the idea of otodontids as ectothermic sharks regardless of the ecological, energetic and body size constraints that this implies. Interestingly, a few recent studies have suggested the possible existence of endothermy in these sharks thus opening the door to a series of new interpretations. Accordingly, this work proposes that regional endothermy was present in otodontids and some closely related taxa (cretoxyrhinids), playing an important role in the evolution of gigantism and in allowing an active mode of live. The existence of regional endothermy in these groups is supported here by three different approaches including isotopic-based approximations, swimming speed inferences and the application of a novel methodology for assessing energetic budget and cost of swimming in extinct taxa. In addition, this finding has wider implications. It calls into question some previous paleotemperature estimates based partially on these taxa, suggests that the existing hypothesis about the evolution of regional endothermy in fishes requires modification, and provides key evidence for understanding the evolution of gigantism in active macropredators. PMID:28938002

Regional endothermy as a trigger for gigantism in some extinct macropredatory sharks.

PubMed

Ferrón, Humberto G

2017-01-01

Otodontids include some of the largest macropredatory sharks that ever lived, the most extreme case being Otodus (Megaselachus) megalodon. The reasons underlying their gigantism, distribution patterns and extinction have been classically linked with climatic factors and the evolution, radiation and migrations of cetaceans during the Paleogene. However, most of these previous proposals are based on the idea of otodontids as ectothermic sharks regardless of the ecological, energetic and body size constraints that this implies. Interestingly, a few recent studies have suggested the possible existence of endothermy in these sharks thus opening the door to a series of new interpretations. Accordingly, this work proposes that regional endothermy was present in otodontids and some closely related taxa (cretoxyrhinids), playing an important role in the evolution of gigantism and in allowing an active mode of live. The existence of regional endothermy in these groups is supported here by three different approaches including isotopic-based approximations, swimming speed inferences and the application of a novel methodology for assessing energetic budget and cost of swimming in extinct taxa. In addition, this finding has wider implications. It calls into question some previous paleotemperature estimates based partially on these taxa, suggests that the existing hypothesis about the evolution of regional endothermy in fishes requires modification, and provides key evidence for understanding the evolution of gigantism in active macropredators.

Spatial Distribution of the Earthquakes beneath the Pamir-Hindu Kush Region: Implications for the Collision between two Oppositely Subducted Slabs

NASA Astrophysics Data System (ADS)

Ning, J.; Lou, X.; Cai, C.; Yu, C.

2009-12-01

We employed a double-difference algorithm (hypoDD) to relocate the Earthquakes reported by the International Seismological Center within the region bounded by 66~78°E and 32~42°N between 1964 and 2003. Among the listed 10224 events in the catalog, 7655 events have at least six P-wave arrival times recorded by 279 stations in the region within 60~90°E and 20~50°N. Totally we have about 135,000 P wave arrival picks and 42,000 S wave arrival picks. 269,365 P-phase pairs and 212,354 S-phase pairs are selected. The average offset between linked events is 10.74 km. The double-difference travel time match in the hypoDD program retains 6018 out of the 7655 events. Then 4751 events are grouped into 182 clusters recorded by 80 stations. The other 1267 events are outliers. Finally 2134 events are successfully relocated and 1479 of them have depth greater than 70 km. There is a distinct feature beneath Hindu Kush region, a double-layered Wadati-Benioff zone which has never been revealed before. Both layers are composed of two parts: the upper part and the lower part. However, the Wadati-Benioff zone in the Pamir region is totally different: it does not have double-layered structure. The Wadati-Benioff zone beneath the Hindu Kush region and the one beneath the Pamir region meet with each other at depth of about 130 km and form back-to-back bow shapes at the boundary region. This explicit feature not only gainsays the statement that a gap exists between the Wadati-Benioff zones beneath the Hindu Kush and the Pamir, but also gainsays the statement that the two Wadati-Benioff zones have geometrical coherence. Based upon above results, along with Harvard CMT solutions, seismological tomography results and geochemical evidences, we propose that beneath the Pamir-Hindu Kush region there exist two oppositely subducted slabs which are colliding with each other at depth of about 130 km. This new model is different from the tear model. It can reasonably explain the Harvard CMT solutions. It naturally relates the intermediate-depth earthquakes under the Pamir with both the intense shallow earthquakes along the northern boundary of the Pamir in Tajikistan and the Ophiolite belt facing south in northern Pamir zone. It also helps us find a way out of the difficulty that Punjab Wedge could not supply enough material diversely subducting into the deep Earth’s interior of Pamir region although it can exert strong extrusion to Pamir zone. When the plate coming from south does not have enough material deeply subducting into the Pamir region, south-concaved northern Pamir arc is indeed the right place for supplying enough material. This new model is also different from the traditional opposing subduction model. It is not based on chanciness. It supplies a reasonable solution to overcome the difficulty that we will face when we find that the seismic gap between the two Wadati-Benioff zones does not exist. When there are no strong evidences for the traditional opposing subduction model, “collision” is the key to reconcile all observations.

Homology analyses of the protein sequences of fatty acid synthases from chicken liver, rat mammary gland, and yeast

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Soo-Ik; Hammes, G.G.

1989-11-01

Homology analyses of the protein sequences of chicken liver and rat mammary gland fatty acid synthases were carried out. The amino acid sequences of the chicken and rat enzymes are 67% identical. If conservative substitutions are allowed, 78% of the amino acids are matched. A region of low homologies exists between the functional domains, in particular around amino acid residues 1059-1264 of the chicken enzyme. Homologies between the active sites of chicken and rat and of chicken and yeast enzymes have been analyzed by an alignment method. A high degree of homology exists between the active sites of the chickenmore » and rat enzymes. However, the chicken and yeast enzymes show a lower degree of homology. The DADPH-binding dinucleotide folds of the {beta}-ketoacyl reductase and the enoyl reductase sites were identified by comparison with a known consensus sequence for the DADP- and FAD-binding dinucleotide folds. The active sites of all of the enzymes are primarily in hydrophobic regions of the protein. This study suggests that the genes for the functional domains of fatty acid synthase were originally separated, and these genes were connected to each other by using different connecting nucleotide sequences in different species. An alternative explanation for the differences in rat and chicken is a common ancestry and mutations in the joining regions during evolution.« less

Divergent Evolutionary Trajectories of Two Young, Homomorphic, and Closely Related Sex Chromosome Systems

PubMed Central

Furman, Benjamin L S; Evans, Ben J

2018-01-01

Abstract There exists extraordinary variation among species in the degree and nature of sex chromosome divergence. However, much of our knowledge about sex chromosomes is based on comparisons between deeply diverged species with different ancestral sex chromosomes, making it difficult to establish how fast and why sex chromosomes acquire variable levels of divergence. To address this problem, we studied sex chromosome evolution in two species of African clawed frog (Xenopus), both of whom acquired novel systems for sex determination from a recent common ancestor, and both of whom have female (ZW/ZZ) heterogamy. Derived sex chromosomes of one species, X. laevis, have a small region of suppressed recombination that surrounds the sex determining locus, and have remained this way for millions of years. In the other species, X. borealis, a younger sex chromosome system exists on a different pair of chromosomes, but the region of suppressed recombination surrounding an unidentified sex determining gene is vast, spanning almost half of the sex chromosomes. Differences between these sex chromosome systems are also apparent in the extent of nucleotide divergence between the sex chromosomes carried by females. Our analyses also indicate that in autosomes of both of these species, recombination during oogenesis occurs more frequently and in different genomic locations than during spermatogenesis. These results demonstrate that new sex chromosomes can assume radically different evolutionary trajectories, with far-reaching genomic consequences. They also suggest that in some instances the origin of new triggers for sex determination may be coupled with rapid evolution sex chromosomes, including recombination suppression of large genomic regions. PMID:29608717

A Nationwide Learning-Style Assessment of Undergraduate Athletic Training Students in CAAHEP-Accredited Athletic Training Programs

PubMed Central

Stradley, Stephanie L.; Buckley, Bernadette D.; Kaminski, Thomas W.; Horodyski, MaryBeth; Fleming, David; Janelle, Christopher M.

2002-01-01

Objective: To identify the learning styles and preferred environmental characteristics of undergraduate athletic training students in Commission on Accreditation of Allied Health Education Programs (CAAHEP)-accredited athletic training education programs and to determine if learning-style differences existed among geographic regions of the country. Design and Setting: Fifty CAAHEP-accredited athletic training programs were randomly selected in proportion to the number of programs in each geographic region. Ten students from each school were selected to complete the Kolb Learning Style Inventory (LSI) and the Productivity Environmental Preference Survey (PEPS). Subjects: A total of 193 undergraduate athletic training students (84 men, 109 women) with a mean age of 22.3 ± 2.8 years completed the PEPS, while 188 students completed the LSI. Measurements: We used chi-square analyses to determine if differences existed in learning-style type and if these differences were based on geographic location. We calculated analysis of variance to determine if there were any geographic differences in the mean overall combination scores of the LSI. Descriptive statistics were used to evaluate the PEPS. Results: The overall return rate was 38%. The chi-square analyses revealed no significant difference in learning-style type for athletic training students, regardless of the geographic region. The LSI yielded a relatively even distribution of learning styles: 29.3% of the students were accommodators, 19.7% were divergers, 21.8% were convergers, and 29.3% were assimilators. The overall mean combination scores were 4.9 (abstract-concrete) and 4.9 (active-reflective), and analysis of variance indicated no significant difference in the mean combination scores among the geographic regions. The PEPS revealed that undergraduate athletic training students demonstrated a strong preference for learning in the afternoon. Conclusions: Undergraduate athletic training students demonstrated great diversity in learning style. Educators must strongly consider this diversity and incorporate teaching methods that will benefit all types of learners. PMID:12937535

Stabilization of a finite slice in miscible displacement in homogeneous porous media

NASA Astrophysics Data System (ADS)

Pramanik, Satyajit; Mishra, Manoranjan

2016-11-01

We numerically studied the miscible displacement of a finite slice of variable viscosity and density. The stability of the finite slice depends on different flow parameters, such as displacement velocity U, mobility ratio R , and the density contrast. Series of numerical simulations corresponding to different ordered pair (R, U) in the parameter space, and a given density contrast reveal six different instability regions. We have shown that independent of the width of the slice, there always exists a region of stable displacement, and below a critical value of the slice width, this stable region increases with decreasing slice width. Further we observe that the viscous fingering (buoyancy-induced instability) at the upper interface induces buoyancy-induced instability (viscous fingering) at the lower interface. Besides the fundamental fluid dynamics understanding, our results can be helpful to model CO2 sequestration and chromatographic separation.

A novel no-reference objective stereoscopic video quality assessment method based on visual saliency analysis

NASA Astrophysics Data System (ADS)

Yang, Xinyan; Zhao, Wei; Ye, Long; Zhang, Qin

2017-07-01

This paper proposes a no-reference objective stereoscopic video quality assessment method with the motivation that making the effect of objective experiments close to that of subjective way. We believe that the image regions with different visual salient degree should not have the same weights when designing an assessment metric. Therefore, we firstly use GBVS algorithm to each frame pairs and separate both the left and right viewing images into the regions with strong, general and week saliency. Besides, local feature information like blockiness, zero-crossing and depth are extracted and combined with a mathematical model to calculate a quality assessment score. Regions with different salient degree are assigned with different weights in the mathematical model. Experiment results demonstrate the superiority of our method compared with the existed state-of-the-art no-reference objective Stereoscopic video quality assessment methods.

Meta-analytic investigations of structural grey matter, executive domain-related functional activations, and white matter diffusivity in obsessive compulsive disorder: an integrative review.

PubMed

Eng, Goi Khia; Sim, Kang; Chen, Shen-Hsing Annabel

2015-05-01

Obsessive-compulsive disorder (OCD) is a debilitating disorder. However, existing neuroimaging findings involving executive function and structural abnormalities in OCD have been mixed. Here we conducted meta-analyses to investigate differences in OCD samples and controls in: Study 1 - grey matter structure; Study 2 - executive function task-related activations during (i) response inhibition, (ii) interference, and (iii) switching tasks; and Study 3 - white matter diffusivity. Results showed grey matter differences in the frontal, striatal, thalamus, parietal and cerebellar regions; task domain-specific neural differences in similar regions; and abnormal diffusivity in major white matter regions in OCD samples compared to controls. Our results reported concurrence of abnormal white matter diffusivity with corresponding abnormalities in grey matter and task-related functional activations. Our findings suggested the involvement of other brain regions not included in the cortico-striato-thalamo-cortical network, such as the cerebellum and parietal cortex, and questioned the involvement of the orbitofrontal region in OCD pathophysiology. Future research is needed to clarify the roles of these brain regions in the disorder. Copyright © 2015 Elsevier Ltd. All rights reserved.

Motion of the moonlet in the binary system 243 Ida

NASA Astrophysics Data System (ADS)

Lan, L.; Ni, Y.; Jiang, Y.; Li, J.

2018-02-01

The motion of the moonlet Dactyl in the binary system 243 Ida is investigated in this paper. First, periodic orbits in the vicinity of the primary are calculated, including the orbits around the equilibrium points and large-scale orbits. The Floquet multipliers' topological cases of periodic orbits are calculated to study the orbits' stabilities. During the continuation of the retrograde near-circular orbits near the equatorial plane, two period-doubling bifurcations and one Neimark-Sacker bifurcation occur one by one, leading to two stable regions and two unstable regions. Bifurcations occur at the boundaries of these regions. Periodic orbits in the stable regions are all stable, but in the unstable regions are all unstable. Moreover, many quasi-periodic orbits exist near the equatorial plane. Long-term integration indicates that a particle in a quasi-periodic orbit runs in a space like a tire. Quasi-periodic orbits in different regions have different styles of motion indicated by the Poincare sections. There is the possibility that moonlet Dactyl is in a quasi-periodic orbit near the stable region I, which is enlightening for the stability of the binary system.

Experimental infections of wild bank voles (Myodes glareolus) from nephropatia epidemica endemic and non-endemic regions revealed slight differences in Puumala virological course and immunological responses.

PubMed

Dubois, Adélaïde; Castel, Guillaume; Murri, Séverine; Pulido, Coralie; Pons, Jean-Baptiste; Benoit, Laure; Loiseau, Anne; Lakhdar, Latifa; Galan, Maxime; Charbonnel, Nathalie; Marianneau, Philippe

2017-05-02

In Europe, the occurrence of nephropathia epidemica (NE), a human disease caused by Puumala virus (PUUV), exhibits considerable geographical heterogeneity despite the continuous distribution of its reservoir, the bank vole Myodes glareolus. To better understand the causes of this heterogeneity, wild voles sampled in two adjacent NE endemic and non-endemic regions of France were infected experimentally with PUUV. The responses of bank voles to PUUV infection, based on the levels of anti-PUUV IgG and viral RNA, were compared. Slight regional differences were highlighted despite the high inter-individual variability. Voles from the NE non-endemic region showed greater immune responsiveness to PUUV infection, but lower levels of RNA in their organs than voles from the endemic region. These results suggest the existence of regional variations in the sensitivity of bank voles that could contribute to the apparent absence of PUUV circulation among voles and the absence of NE in the non-endemic region. Copyright © 2017 Elsevier B.V. All rights reserved.

Semi-analytical study of the tokamak pedestal density profile in a single-null diverted plasma with puffing-recycling gas sources

NASA Astrophysics Data System (ADS)

Shi, Bingren

2010-10-01

The tokamak pedestal density structure is generally studied using a diffusion-dominant model. Recent investigations (Stacey and Groebner 2009 Phys. Plasmas 16 102504) from first principle based physics have shown a plausible existence of large inward convection in the pedestal region. The diffusion-convection equation with rapidly varying convection and diffusion coefficients in the near edge region and model puffing-recycling neutral particles is studied in this paper. A peculiar property of its solution for the existence of the large convection case is that the pedestal width of the density profile, qualitatively different from the diffusion-dominant case, depends mainly on the width of the inward convection and only weakly on the neutral penetration length and its injection position.

Differences in Parental Involvement Typologies among Baby Boomers, Generation X, and Generation Y Parents: A Study of Select Bay Area Region of Houston Elementary Schools

ERIC Educational Resources Information Center

Veloz, Elizabeth Andrea

2010-01-01

The purpose of this study was to determine whether differences existed among generations (Baby Boomers, Generation X, and Generation Y) regarding the levels of parental involvement within each of these generations. Also examined were additional factors such as the parents. socioeconomic status, educational level, marital status, and ethnicity. The…

Flooding risks: a comparison of lay people's perceptions and expert's assessments in Switzerland.

PubMed

Siegrist, Michael; Gutscher, Heinz

2006-08-01

Experts on the risk of flooding have developed very detailed maps for different parts of Switzerland that indicate the types of damage possible and the probabilities of adverse events. Four categories of risk severity are defined on the maps, ranging from high risk to no risk. Based on these existing maps, we selected respondents for a mail survey, some from areas high in risk and others from low-risk regions. Respondents answered several questions related to flood risk perception and preparedness. Survey results showed that respondents' risk perceptions were correlated with the experts' risk assessments. Respondents who lived in areas designated "no risk" by the experts had lower perceptions of risk than respondents who lived in areas with higher levels of designated risk. With regard to concrete prevention behavior, no differences between people living in different risk areas were observed. Survey results further suggest that many inhabitants do not know that flooding maps exist for their region. Results suggest that in some regions people overestimate the risks associated with flooding. Consequently, some people are more afraid of flooding than is justified by the facts. Some people show prevention behavior that most likely is superfluous. However, in other regions people underestimate the risks associated with flooding. These people do not show prevention behavior, and they are not well prepared for an adverse event. Furthermore, results suggest that respondents' experiences with flooding are positively related to their perceptions of flood risk. Findings of the present study are in line with the availability heuristic.

Major Histocompatibility Complex Genes Map to Two Chromosomes in an Evolutionarily Ancient Reptile, the Tuatara Sphenodon punctatus

PubMed Central

Miller, Hilary C.; O’Meally, Denis; Ezaz, Tariq; Amemiya, Chris; Marshall-Graves, Jennifer A.; Edwards, Scott

2015-01-01

Major histocompatibility complex (MHC) genes are a central component of the vertebrate immune system and usually exist in a single genomic region. However, considerable differences in MHC organization and size exist between different vertebrate lineages. Reptiles occupy a key evolutionary position for understanding how variation in MHC structure evolved in vertebrates, but information on the structure of the MHC region in reptiles is limited. In this study, we investigate the organization and cytogenetic location of MHC genes in the tuatara (Sphenodon punctatus), the sole extant representative of the early-diverging reptilian order Rhynchocephalia. Sequencing and mapping of 12 clones containing class I and II MHC genes from a bacterial artificial chromosome library indicated that the core MHC region is located on chromosome 13q. However, duplication and translocation of MHC genes outside of the core region was evident, because additional class I MHC genes were located on chromosome 4p. We found a total of seven class I sequences and 11 class II β sequences, with evidence for duplication and pseudogenization of genes within the tuatara lineage. The tuatara MHC is characterized by high repeat content and low gene density compared with other species and we found no antigen processing or MHC framework genes on the MHC gene-containing clones. Our findings indicate substantial differences in MHC organization in tuatara compared with mammalian and avian MHCs and highlight the dynamic nature of the MHC. Further sequencing and annotation of tuatara and other reptile MHCs will determine if the tuatara MHC is representative of nonavian reptiles in general. PMID:25953959

Local homogeneity of cell cycle length in developing mouse cortex

NASA Technical Reports Server (NTRS)

Cai, L.; Hayes, N. L.; Nowakowski, R. S.

1997-01-01

We have measured the amount of variation in the length of the cell cycle for cells in the pseudostratified ventricular epithelium (PVE) of the developing cortex of mice on embryonic day 14. Our measurements were made in three cortical regions (i.e., the neocortex, archicortex, and periarchicortex) using three different methods: the cumulative labeling method (CLM), the percent labeled mitoses (PLM) method, and a comparison of the time needed for the PLM to ascend from 0 to 100% with the time needed for the PLM to descend from 100 to 0%. These 3 different techniques provide different perspectives on the cytokinetic parameters. Theoretically, CLM gives an estimate for a maximum value of the total length of the cell cycle (TC), whereas PLM gives an estimate of a minimum value of TC. The difference between these two estimates indicates that the range for TC is +/-1% of the mean TC for periarchicortex, +/-7% for neocortex, and +/-8% for archicortex. This was confirmed by a lengthening of the PLM descent time in comparison with its ascent time. The sharpness of the transitions and the flatness of the plateau of the PLM curves indicate that 99% of the proliferating cells are within this narrow estimated range for TC; hence, only approximately 1% deviate outside of a relatively restricted range from the average TC of the population. In the context of the possible existence within the cortical PVE of two populations with markedly dissimilar cell cycle kinetics from the mean, one such population must comprise approximately 99% of the total population, and the other, if it exists, is only approximately 1% of the total. This seems to be true for all three cortical regions. The narrow range of TC indicates a homogeneity in the cell cycle length for proliferating cells in three different cortical regions, despite the fact that progenitor cells of different lineages may be present. It further predicts the existence of almost synchronous interkinetic nuclear movements of the proliferating cells in the ventricular zone during early development of the cerebral cortex.

Gravastars in f (G ,T ) gravity

NASA Astrophysics Data System (ADS)

Shamir, M. Farasat; Ahmad, Mushtaq

2018-05-01

This work proposes a stellar model under Gauss-Bonnet f (G ,T ) gravity with the conjecture theorized by Mazur and Mottola, well known as the gravitational vacuum stars (gravastars). By taking into account the f (G ,T ) stellar model, the structure of the gravastar with its exclusive division of three different regions, namely, (i) the core interior region, (ii) the junction region (shell), and (iii) the exterior region, has been investigated with reference to the existence of energy density, pressure, ultrarelativistic plasma, and repulsive forces. The different physical features, like the equation of state parameter, length of the shell, entropy, and energy-thickness relation of the gravastar shell model, have been discussed. Also, some other physically valid aspects have been presented with the connection to nonsingular and event-horizon-free gravastar solutions, which in contrast to a black hole solution, might be stable without containing any information paradox.

Symmetry breaking, and the effect of matter density on neutrino oscillation

NASA Astrophysics Data System (ADS)

Mohseni Sadjadi, H.; Khosravi Karchi, A. P.

2018-04-01

A proposal for the neutrino mass, based on neutrino-scalar field interaction, is introduced. The scalar field is also non-minimally coupled to the Ricci scalar, and hence relates the neutrino mass to the matter density. In a dense region, the scalar field obeys the Z2 symmetry, and the neutrino is massless. In a dilute region, the Z2 symmetry breaks and neutrino acquires mass from the non-vanishing expectation value of the scalar field. We consider this scenario in the framework of a spherical dense object whose outside is a dilute region. In this background, we study the neutrino flavors oscillation, along with the consequences of the theory on oscillation length and MSW effect. This preliminary model may shed some lights on the existing anomalies within the neutrino data, concerning the different oscillating behavior of the neutrinos in regions with different densities.

A salient region detection model combining background distribution measure for indoor robots.

PubMed

Li, Na; Xu, Hui; Wang, Zhenhua; Sun, Lining; Chen, Guodong

2017-01-01

Vision system plays an important role in the field of indoor robot. Saliency detection methods, capturing regions that are perceived as important, are used to improve the performance of visual perception system. Most of state-of-the-art methods for saliency detection, performing outstandingly in natural images, cannot work in complicated indoor environment. Therefore, we propose a new method comprised of graph-based RGB-D segmentation, primary saliency measure, background distribution measure, and combination. Besides, region roundness is proposed to describe the compactness of a region to measure background distribution more robustly. To validate the proposed approach, eleven influential methods are compared on the DSD and ECSSD dataset. Moreover, we build a mobile robot platform for application in an actual environment, and design three different kinds of experimental constructions that are different viewpoints, illumination variations and partial occlusions. Experimental results demonstrate that our model outperforms existing methods and is useful for indoor mobile robots.

Modification and implementation of NCCN guidelines on lymphomas in the Middle East and North Africa region.

PubMed

Bazarbachi, Ali; Azim, Hamdy A; Alizadeh, Hussain; Aljurf, Mahmoud; Barista, Ibrahim; Chaudhri, Naeem A; Fahed, Zahira; Fahmy, Omar A; Ghavamzadeh, Ardeshir; Khalaf, Mohamed H; Khatib, Sami; Kutoubi, Aghiad; Paydas, Semra; Elayoubi, Hanadi Rafii; Zaatari, Ghazi; Zawam, Hamdy M; Zelenetz, Andrew D

2010-07-01

In the Middle East and North Africa (MENA) region, cancer has many epidemiologic and clinical features that are different from those in the rest of the world. Additionally, the region has a relatively young population and large disparities in the availability of resources at diagnostic and treatment levels. A critical need exists for regional guidelines on cancer care, including those for lymphoid malignancies. A panel of lymphoma experts from MENA reviewed the 2009 version of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) on Non-Hodgkin's Lymphoma and Hodgkin Lymphoma and suggested modifications for the region that were discussed with the United States NCCN Lymphoma Panels. This article presents the consensus recommendations.

Regional differences in endothelial cell cytoskeleton, junctional proteins and phosphorylated tyrosine labeling in the porcine vortex vein system.

PubMed

Tan, Priscilla Ern Zhi; Yu, Paula K; Yang, Hongfang; Cringle, Stephen J; Yu, Dao-Yi

2018-07-01

We previously demonstrated endothelial phenotype heterogeneity in the vortex vein system. This study is to further determine whether regional differences are present in the cytoskeleton, junctional proteins and phosphorylated tyrosine labeling within the system. The vortex vein system of twenty porcine eyes was perfused with labels for f-actin, claudin-5, VE-Cadherin, phosphorylated tyrosine and nucleic acid. The endothelial cells of eight different regions (choroidal veins, pre-ampulla, anterior ampulla, mid-ampulla, posterior ampulla, post-ampulla, intra-scleral canal and the extra-ocular vortex vein) were studied using confocal microscopy. There were regional differences in the endothelial cell structures. Cytoskeleton labeling was relatively even in intensity throughout Regions 1 to 6. Overall VE-Cadherin had a non-uniform distribution and thicker width endothelial cell border staining than claudin-5. Progressing downstream there was an increased variation in thickness of VE-cadherin labeling. There was an overlap in phosphorylated tyrosine and VE-Cadherin labeling in the post-ampulla, intra-scleral canal and extra-ocular vortex vein. Intramural cells were observed that were immune-positive for VE-Cadherin and phosphorylated tyrosine. There were significant differences in the number of intramural cells in different regions. Significant regional differences with endothelial cell labeling of cytoskeleton, junction proteins, and phosphorylated tyrosine were found within the vortex vein system. These findings support existing data on endothelial cell phenotype heterogeneity, and may aid in the knowledge of venous pathologies by understanding regions of vulnerability to endothelial damage within the vortex vein system. It could be valuable to further investigate and characterize the VE-cadherin and phosphotyrosine immune-positive intramural cells. Copyright © 2018. Published by Elsevier Ltd.

Cross-cultural consistency and diversity in intrinsic functional organization of Broca's Region.

PubMed

Zhang, Yu; Fan, Lingzhong; Caspers, Svenja; Heim, Stefan; Song, Ming; Liu, Cirong; Mo, Yin; Eickhoff, Simon B; Amunts, Katrin; Jiang, Tianzi

2017-04-15

As a core language area, Broca's region was consistently activated in a variety of language studies even across different language systems. Moreover, a high degree of structural and functional heterogeneity in Broca's region has been reported in many studies. This raised the issue of how the intrinsic organization of Broca's region effects by different language experiences in light of its subdivisions. To address this question, we used multi-center resting-state fMRI data to explore the cross-cultural consistency and diversity of Broca's region in terms of its subdivisions, connectivity patterns and modularity organization in Chinese and German speakers. A consistent topological organization of the 13 subdivisions within the extended Broca's region was revealed on the basis of a new in-vivo parcellation map, which corresponded well to the previously reported receptorarchitectonic map. Based on this parcellation map, consistent functional connectivity patterns and modularity organization of these subdivisions were found. Some cultural difference in the functional connectivity patterns was also found, for instance stronger connectivity in Chinese subjects between area 6v2 and the motor hand area, as well as higher correlations between area 45p and middle frontal gyrus. Our study suggests that a generally invariant organization of Broca's region, together with certain regulations of different language experiences on functional connectivity, might exists to support language processing in human brain. Copyright © 2017 Elsevier Inc. All rights reserved.

Etiology of Childhood Infectious Diarrhea in a Developed Region of China: Compared to Childhood Diarrhea in a Developing Region and Adult Diarrhea in a Developed Region.

PubMed

Wang, Xin; Wang, Jing; Sun, Hao; Xia, Shengli; Duan, Ran; Liang, Junrong; Xiao, Yuchun; Qiu, Haiyan; Shan, Guangliang; Jing, Huaiqi

2015-01-01

In China, great differences in economy, social characteristics and hygiene exist between developing and developed regions. A comparative study of infectious diarrhea between two regions was needed. Three groups of diarrheal patients were collected: children ≤5 year-olds from Beijing (developed region) and Henan Province (developing region), and adults over 18 year-olds from Beijing. A questionnaire was used to survey and feces samples were examined for 16 enteropathogens. We enrolled 1422 children and 1047 adults from developed region and 755 children from developing region. Virus positive rates were 32.98% for children and 23.67% for adults in developed region. The most prevalent pathogen for children was rotavirus whereas for adults was norovirus. Bacterial isolation rates were 13.92% for children from developed region, while 29.14% for children from the developing regions. For the greatest difference, Shigella accounted for 50.79% and was the dominant pathogen in the developing region, whereas in the developed region it was only 1.45%. There was no significant relationship between the local levels of development with diarrheogenic Escherichia coli (DEC) categories. But it was seen the notable differences between the population with different age: enteropathogenic E.coli (EPEC) and enteroaggregative E.coli (EAggEC) were the primary classes of DEC in children from both regions, whereas it was enterotoxigenic E.coli (ETEC) in adults. The symptoms of Shigella and Salmonella infection, such as bloody stools, white blood cells (WBC) and red blood cells (RBC) positivity and fever were similar in children, which may lead to the misidentification. Yersinia enterocolitica and shiga toxin-producing E.coli (STEC) infections were firstly reported in Beijing. There was a large difference in etiology of bacterial diarrhea between children in developing and developed regions of China.

Mid-infrared (5.0-7.0 microns) imaging spectroscopy of the moon from the KAO

NASA Technical Reports Server (NTRS)

Bell, James F., III; Bregman, Jesse D.; Rank, David M.; Temi, Pasquale; Roush, Ted L.; Hawke, B. Ray; Lucey, Paul G.; Pollack, James B.

1995-01-01

A series of 71 mid-infrared images of a small region of the Moon were obtained from the KAO in October, 1993. These images have been assembled into a 5.0 to 7.0 micron image cube that has been calibrated relative to the average spectrum of this region of the Moon at these wavelengths. The data show that clear, detectable spectral differences exist on the Moon in the mid-IR. Some of the spectral differences are correlated with morphologic features such as craters. Specific spectral features near 5.6 and 6.7 microns may be related to the presence of plagioclase or pyroxene.

The Response and Repairing of Three Kinds of Crops on Xi’an’s Sewage Irrigation Area Soil

NASA Astrophysics Data System (ADS)

Xin, H.; Zhimei, Z.; Lei, H.; Huan, L.; Tian, Z.

2017-10-01

This paper focuses on the XiChaZhai village’s vegetable soil which is located in the northern suburbs of Xi’an and on its vegetables, thus analyzes the quality of sewage irrigation region soil and its influence on vegetables through the measurement of Cu, Zn, Pb, Cd’s content in samples. The results show that the research area soil contains apparently excessive heavy metals, and there exists significant differences of different elements’ integrated intensity in soil, the content declines in sequence from Cd, Zn, Pb to Cu. The four heavy metals’ contents in sewage irrigation region soil vary greatly from that in non-sewage irrigation region soil(P<0.01). Raphanus sativus and Ottelia acuminate have favorable effects on Cd and Cu’s accumulation. Three crops having repairing effects on Xi’an sewage irrigation region soil are Raphanus sativus, Ottelia acuminate and Brassica chinensis, in that order. Different crop tissues differ in the accumulation of heavy metal, the order according as roots, stem and leaves, fruits. Therefore, based on differences of various crops on heavy metals’ absorption and translocation, appropriate crops should be scientifically planted in heavy metal contaminated area soil.

Environment degradation, economic growth and energy consumption nexus: A wavelet-windowed cross correlation approach

NASA Astrophysics Data System (ADS)

Jammazi, Rania; Aloui, Chaker

2015-10-01

This paper analyzes the interactive linkages between carbon dioxide (CO2) emissions, energy consumption (EC) and economic growth (EG) using a novel approach namely wavelet windowed cross correlation (WWCC) for six oil-exporting countries from the GCC (Gulf Cooperation Council) region over the period 1980-2012. Our empirical results show that there exists a bidirectional causal relationship between EC and EG. However, the results support the occurrence of unidirectional causality from EC to CO2 emissions without any feedback effects, and there exists a bidirectional causal relationship between EG and CO2 emissions for the region as a whole. The study suggests that environmental and energy policies should recognize the differences in the nexus between EC and EG in order to maintain sustainable EG in the GCC region. Our findings will be useful for GCC countries to better evaluate its situation in the future climate negotiations. The overall findings will help GCC countries assess its position better in future climate change negotiations.

An Integrated Geophysical and Tectonic Study of the Structure and Evolution of the Crust in the Snake River Plain Region, Pacific Northwest

NASA Astrophysics Data System (ADS)

Keller, G. R.; Khatiwada, M.

2016-12-01

The Snake River Plain region in the Pacific Northwest of North America has been the target of a number of recent studies that have revealed further complexities in its structure and tectonic evolution. Based on surface morphology and Late Cenozoic volcanic activity, the Snake River Plain consists of an eastern and western arm (ESRP and WSRP) that are similar in many respects but also quite different in other respects. Thus, its origin, evolution, structural complexities, the role of extension and magmatism in its formation, and the tectonic drivers are still subjects of debate. Numerous seismic studies have specifically focused on the structure of the ESRP and Yellowstone area. However, crustal-scale studies of the WSRP are limited. We added new gravity data to the existing coverage in the WSRP region and undertook a regional, integrated analysis approach that included magnetic, seismic reflection and refraction profiling, receiver function results, geological and geospatial data, and interpreted well logs. Our integrated geophysical modeling focused on the structure of the WSRP. We generated two crustal models across it at locations where the most existing geophysical and geological constraints were available. We observed both differences and similarities in the structure of the WSRP and ESRP. Although, the shallow crustal structures are different, a mid-crustal mafic intrusion is a major source of the high gravity anomaly values. Within the context of recent studies in the surrounding region, the intersection of the two arms of the Snake River Plain emerges as a major element of a complex tectonic intersection that includes the High Lava Plains of eastern Oregon, the Northern Nevada Rift, a southwestern extension of the ESRP into northern Nevada, as well as, faulting and volcanism extending northwestward to connect with the Columbia River Basalts region.

Regional and Gender Differences and Trends in the Anesthesiologist Workforce.

PubMed

Baird, Matthew; Daugherty, Lindsay; Kumar, Krishna B; Arifkhanova, Aziza

2015-11-01

Concerns have long existed about potential shortages in the anesthesiologist workforce. In addition, many changes have occurred in the economy, demographics, and the healthcare sector in the last few years, which may impact the workforce. The authors documented workforce trends by region of the United States and gender, trends that may have implications for the supply and demand of anesthesiologists. The authors conducted a national survey of American Society of Anesthesiologists members (accounting for >80% of all practicing anesthesiologists in the United States) in 2007 and repeated it in 2013. The authors used logistic regression analysis and Seemingly Unrelated Regression to test across several indicators under an overarching hypothesis. Anesthesiologists in Western states had markedly different patterns of practice relative to anesthesiologists in other regions in 2007 and 2013, including differences in employer type, the composition of anesthesia teams, and the time spent on monitored anesthesia care. The number and proportion of female anesthesiologists in the workforce increased between 2007 and 2013, and females differed from males in employment arrangements, compensation, and work hours. Regional differences remained stable during this time period although the reasons for these differences are speculative. Similarly, how and whether the gender difference in work hours and shift to younger anesthesiologists during this period will impact workforce needs is uncertain.

Pricing Models for Dual-channel Reverse Supply Chain Considering Regional Differences under “Internet Recycling” Mode in China

NASA Astrophysics Data System (ADS)

Wu, Di; Li, Peng; Chen, Juhong

2018-01-01

In recent years, the Internet technology has been deeply influencing recycling industry to make it more intelligent and interconnected. However, most existing papers on “Internet Recycling” neglected the problem of pricing strategy under online and offline channels for different levels of recyclers. Moreover, the effect of regional differences has been emphasized a lot in dual-channel forward supply chain, but recycling field has seldom been concerned about it. In this paper, a recycling system consisting of one recycling center and several third-party recyclers (TPR) was investigated based on traditional mode and dual-channel mode. The dual-channel reverse supply chain model is transformed from traditional mode by the introduction of online channel. It involves two recycling modes, as recycling centre for online recovery and “Recycling center+TPR” for offline recovery. By establishing pricing strategies based on Stackelberg game model, the impacts of regional differences were analysed. Finally, numerical analysis was given to illustrate the effectiveness of the pricing mechanisms and strategies.

[Effects of road construction on regional vegetation types].

PubMed

Liu, Shi-Liang; Liu, Qi; Wang, Cong; Yang, Jue-Jie; Deng, Li

2013-05-01

As a regional artificial disturbance component, road exerts great effects on vegetation types, and plays a substantial role in defining vegetation distribution to a certain extent. Aiming at the tropical rainforest degradation and artificial forest expansion in Yunnan Province of Southwest China, this paper analyzed the effects of road network extension on regional vegetation types. In the Province, different classes of roads had different effects on the vegetation types, but no obvious regularity was observed in the effects on the patch areas of different vegetation types due to the great variations of road length and affected distance. However, the vegetation patch number was more affected by lower class roads because of their wide distribution. As for different vegetation types, the vegetations on cultivated land were most affected by roads, followed by Castanopsis hystrix and Schima wallichii forests. Road network formation contributed most to the vegetation fragmentation, and there existed significant correlations between the human disturbance factors including village- and road distributions.

Imaging a Time-variant Earthquake Focal Region along an Interplate Boundary

NASA Astrophysics Data System (ADS)

Tsuruga, K.; Kasahara, J.; Hasada, Y.; Fujii, N.

2010-12-01

We show a preliminary result of a trial for detecting a time-variant earthquake focal region along an interplate boundary by means of a new imaging method through a numerical simulation. Remarkable seismic reflections from the interplate boundaries of a subducting oceanic plate have been observed in Japan Trench (Mochizuki et al, 2005) and in Nankai Trough (Iidaka et al., 2003). Those strong seismic reflection existing in the current aseismic zones suggest the existence of fluid along the subduction boundary, and it is considered that they closely relate to a future huge earthquake. Seismic ACROSS has a potential to monitor some changes of transfer function along the propagating ray paths, by using an accurately-controlled transmission and receiving of the steady continuous signals repeatedly (Kumazawa et al., 2000). If the physical state in a focal region along the interplate would be changed enough in the time and space, for instance, by increasing or decreasing of fluid flow, we could detect some differences of the amplitude and/or travel-time of the particular reflection phases from the time-variant target region. In this study, we first investigated the seismic characteristics of seismograms and their differences before and after the change of a target region through a numerical simulation. Then, as one of the trials, we attempted to make an image of such time-variant target region by applying a finite-difference back-propagation technique in the time and space to the differences of waveforms (after Kasahara et al., 2010). We here used a 2-D seismic velocity model in the central Japan (Tsuruga et al., 2005), assuming a time-variant target region with a 200-m thickness along a subducting Philippine Sea plate at 30 km in depth. Seismograms were calculated at a 500-m interval for 260 km long by using FDM software (Larsen, 2000), in the case that P- and S-wave velocities (Vp amd Vs) in the target region decreased about 30 % before to after the change (e.g., Vp=3.5 km/s to 2.5 km/s). After applying the new imaging method to the differences between both seismograms at each receiver, it is clear that the remarkable signals related with the target change were focused around the target region during a particular back-propagation time. As a preliminary result, it is not still easy to exactly identify the geometry and shape of the target region. However, we can conclude that it is almost possible to decide the location of the target region by means of an optimized receiver array together with the seismic source which can transmit the accurate and steady signals repeatedly as like as ACROSS even if a single source.

Characterization of cocoa production, income diversification and shade tree management along a climate gradient in Ghana.

PubMed

Abdulai, Issaka; Jassogne, Laurence; Graefe, Sophie; Asare, Richard; Van Asten, Piet; Läderach, Peter; Vaast, Philippe

2018-01-01

Reduced climatic suitability due to climate change in cocoa growing regions of Ghana is expected in the coming decades. This threatens farmers' livelihood and the cocoa sector. Climate change adaptation requires an improved understanding of existing cocoa production systems and farmers' coping strategies. This study characterized current cocoa production, income diversification and shade tree management along a climate gradient within the cocoa belt of Ghana. The objectives were to 1) compare existing production and income diversification between dry, mid and wet climatic regions, and 2) identify shade trees in cocoa agroforestry systems and their distribution along the climatic gradient. Our results showed that current mean cocoa yield level of 288kg ha-1yr-1 in the dry region was significantly lower than in the mid and wet regions with mean yields of 712 and 849 kg ha-1 yr-1, respectively. In the dry region, farmers diversified their income sources with non-cocoa crops and off-farm activities while farmers at the mid and wet regions mainly depended on cocoa (over 80% of annual income). Two shade systems classified as medium and low shade cocoa agroforestry systems were identified across the studied regions. The medium shade system was more abundant in the dry region and associated to adaptation to marginal climatic conditions. The low shade system showed significantly higher yield in the wet region but no difference was observed between the mid and dry regions. This study highlights the need for optimum shade level recommendation to be climatic region specific.

Characterization of cocoa production, income diversification and shade tree management along a climate gradient in Ghana

PubMed Central

Jassogne, Laurence; Graefe, Sophie; Asare, Richard; Van Asten, Piet; Läderach, Peter; Vaast, Philippe

2018-01-01

Reduced climatic suitability due to climate change in cocoa growing regions of Ghana is expected in the coming decades. This threatens farmers’ livelihood and the cocoa sector. Climate change adaptation requires an improved understanding of existing cocoa production systems and farmers’ coping strategies. This study characterized current cocoa production, income diversification and shade tree management along a climate gradient within the cocoa belt of Ghana. The objectives were to 1) compare existing production and income diversification between dry, mid and wet climatic regions, and 2) identify shade trees in cocoa agroforestry systems and their distribution along the climatic gradient. Our results showed that current mean cocoa yield level of 288kg ha-1yr-1 in the dry region was significantly lower than in the mid and wet regions with mean yields of 712 and 849 kg ha-1 yr-1, respectively. In the dry region, farmers diversified their income sources with non-cocoa crops and off-farm activities while farmers at the mid and wet regions mainly depended on cocoa (over 80% of annual income). Two shade systems classified as medium and low shade cocoa agroforestry systems were identified across the studied regions. The medium shade system was more abundant in the dry region and associated to adaptation to marginal climatic conditions. The low shade system showed significantly higher yield in the wet region but no difference was observed between the mid and dry regions. This study highlights the need for optimum shade level recommendation to be climatic region specific. PMID:29659629

Understanding Context: Cultural, Relational, & Psychological Interactions in Self-Authorship Development

ERIC Educational Resources Information Center

Pizzolato, Jane Elizabeth; Nguyen, Tu-Lien Kim; Johnston, Marc P.; Wang, Sherry

2012-01-01

Existing research points toward dissonance as the primary catalyst in self-authorship development. This study investigated the cultural relevance of current conceptions of dissonance's role in self-authorship development. A total of 166 participants of color were recruited from three large public research universities from different regions in the…

Indicators for Measuring Entrepreneurship: A Proposal for a Scoreboard

ERIC Educational Resources Information Center

Leitao da Silva Martins, Susana Paula

2007-01-01

Indicators for measuring and comparing entrepreneurship in different regions are important tools for understanding economic and social development and formulating strategies to bring improvements to less developed areas. The existing indicators are not adequate for this purpose because they do not link the economic and social factors that…

Chemically and geographically distinct solid-phase iron pools in the Southern Ocean.

PubMed

von der Heyden, B P; Roychoudhury, A N; Mtshali, T N; Tyliszczak, T; Myneni, S C B

2012-11-30

Iron is a limiting nutrient in many parts of the oceans, including the unproductive regions of the Southern Ocean. Although the dominant fraction of the marine iron pool occurs in the form of solid-phase particles, its chemical speciation and mineralogy are challenging to characterize on a regional scale. We describe a diverse array of iron particles, ranging from 20 to 700 nanometers in diameter, in the waters of the Southern Ocean euphotic zone. Distinct variations in the oxidation state and composition of these iron particles exist between the coasts of South Africa and Antarctica, with different iron pools occurring in different frontal zones. These speciation variations can result in solubility differences that may affect the production of bioavailable dissolved iron.

The existence of a sticking region in free weight squats.

PubMed

van den Tillaar, Roland; Andersen, Vidar; Saeterbakken, Atle Hole

2014-09-29

The aim of this study was to investigate the existence of the sticking region in two legged free weight squats. Fifteen resistance-training males (age 24 ± 4 years, body mass 82 ± 11 kg, body height 179 ± 6 cm) with 6 ± 3 years of resistance-training experience performed 6-RM in free weight squats. The last repetition was analyzed for the existence of a sticking region. Only in 10 out of 15 participants a sticking region was observed. The observed sticking region was much shorter than in the bench press. Furthermore, rectus femoris decreased the EMG activity in contrast to increased EMG activity in biceps femoris around the sticking and surrounding region. No significant change in EMG activity was found for the lateral and medial vastus muscles. It is suggested that a combination of these muscle activity changes could be one of the causes of the existence of the sticking region in free weight squats.

The Existence of a Sticking Region in Free Weight Squats

PubMed Central

van den Tillaar, Roland; Andersen, Vidar; Saeterbakken, Atle Hole

2014-01-01

The aim of this study was to investigate the existence of the sticking region in two legged free weight squats. Fifteen resistance-training males (age 24 ± 4 years, body mass 82 ± 11 kg, body height 179 ± 6 cm) with 6 ± 3 years of resistance-training experience performed 6-RM in free weight squats. The last repetition was analyzed for the existence of a sticking region. Only in 10 out of 15 participants a sticking region was observed. The observed sticking region was much shorter than in the bench press. Furthermore, rectus femoris decreased the EMG activity in contrast to increased EMG activity in biceps femoris around the sticking and surrounding region. No significant change in EMG activity was found for the lateral and medial vastus muscles. It is suggested that a combination of these muscle activity changes could be one of the causes of the existence of the sticking region in free weight squats. PMID:25414740

Turkish community pharmacists’ self-report of their pharmacies’ physical atmosphere

PubMed Central

Cagirci, Simge; Yegenoglu, Selen; Uner, Mehmet Mithat

2012-01-01

Objective: There is a great recognition that store interiors and exteriors can be designed to create feelings in potential customers which can have an important reinforcing effect on purchase. In this study it is mainly aimed to explore the behaviors of the community pharmacists related to their store's physical environment. Also we aimed to determine whether any difference exist between behaviors of pharmacists serving in high and low socio-economic regions. Methods: A total of 200 pharmacists that work socio-economically different regions were randomly selected from 1424 pharmacists registered in Ankara Chamber of Pharmacists. A uniform questionnaire was applied to the pharmacists by using a face-to-face interview technique. Findings: There are differences in terms of behavior between the pharmacists serving in high and low socio-economic regions within the context of putting importance to their stores’ atmosphere. More pharmacists attach importance to the physical sight of their pharmacy serving in high socio-economic regions (90%) vs. pharmacists in low socio-economic regions (70%). Also pharmacists in high socio-economic regions indicated higher importance level of selection of the decoration equipments (84%) than pharmacists serving in high socio-economic regions (60%). Conclusion: Our study suggests that some pharmacists pay more attention to interior atmospheric elements and others do not. There is a difference in terms of attaching importance to some store atmospheric elements (i.e. physical site, decoration equipment, it's color, wall color, etc.) serving in high versus low socio-economic regions in this context. PMID:24991582

Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae.

PubMed

Checa, Sara; Hesse, Bernhard; Roschger, Paul; Aido, Marta; Duda, Georg N; Raum, Kay; Willie, Bettina M

2015-07-01

Although it is well known that the bone adapts to changes in the mechanical environment by forming and resorbing the bone matrix, little is known about the influence of mechanical loading on tissue material properties of the pre-existing and newly formed bone. In this study, we analyzed the newly formed and pre-existing tissue after two weeks of controlled in vivo axial compressive loading in tibia of young (10 week-old) and adult (26 week-old) female mice and compared to the control contralateral limb, by means of scanning acoustic microscopy. Additionally, we used quantitative backscattered electron imaging to determine the bone mineral density distribution within the newly formed and pre-existing bone of young mice. No significant differences were found in tissue stiffness or mineral density in the pre-existing bone tissue as a result of external loading. In the endosteal region, 10 and 26 week loaded animals showed a 9% reduction in bone tissue stiffness compared to control animals. An increase of 200% in the mineral apposition rate in this region was observed in both age groups. In the periosteal region, the reduction in bone tissue stiffness and the increase in bone mineral apposition rate as a result of loading were two times higher in the 10 compared to the 26 week old animals. These data suggest that, during growth and skeletal maturation, the response of bone to mechanical loading is a deposition of new bone matrix, where the tissue amount but not its mineral or elastic properties are influenced by animal age. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Do regional methods really help reduce uncertainties in flood frequency analyses?

NASA Astrophysics Data System (ADS)

Cong Nguyen, Chi; Payrastre, Olivier; Gaume, Eric

2013-04-01

Flood frequency analyses are often based on continuous measured series at gauge sites. However, the length of the available data sets is usually too short to provide reliable estimates of extreme design floods. To reduce the estimation uncertainties, the analyzed data sets have to be extended either in time, making use of historical and paleoflood data, or in space, merging data sets considered as statistically homogeneous to build large regional data samples. Nevertheless, the advantage of the regional analyses, the important increase of the size of the studied data sets, may be counterbalanced by the possible heterogeneities of the merged sets. The application and comparison of four different flood frequency analysis methods to two regions affected by flash floods in the south of France (Ardèche and Var) illustrates how this balance between the number of records and possible heterogeneities plays in real-world applications. The four tested methods are: (1) a local statistical analysis based on the existing series of measured discharges, (2) a local analysis valuating the existing information on historical floods, (3) a standard regional flood frequency analysis based on existing measured series at gauged sites and (4) a modified regional analysis including estimated extreme peak discharges at ungauged sites. Monte Carlo simulations are conducted to simulate a large number of discharge series with characteristics similar to the observed ones (type of statistical distributions, number of sites and records) to evaluate to which extent the results obtained on these case studies can be generalized. These two case studies indicate that even small statistical heterogeneities, which are not detected by the standard homogeneity tests implemented in regional flood frequency studies, may drastically limit the usefulness of such approaches. On the other hand, these result show that the valuation of information on extreme events, either historical flood events at gauged sites or estimated extremes at ungauged sites in the considered region, is an efficient way to reduce uncertainties in flood frequency studies.

On the structure of existence regions for sinks of the Hénon map

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galias, Zbigniew, E-mail: galias@agh.edu.pl; Tucker, Warwick, E-mail: warwick@math.uu.se

2014-03-15

An extensive search for stable periodic orbits (sinks) for the Hénon map in a small neighborhood of the classical parameter values is carried out. Several parameter values which generate a sink are found and verified by rigorous numerical computations. Each found parameter value is extended to a larger region of existence using a simplex continuation method. The structure of these regions of existence is investigated. This study shows that for the Hénon map, there exist sinks close to the classical case.

Experimental identification of a comb-shaped chaotic region in multiple parameter spaces simulated by the Hindmarsh—Rose neuron model

NASA Astrophysics Data System (ADS)

Jia, Bing

2014-03-01

A comb-shaped chaotic region has been simulated in multiple two-dimensional parameter spaces using the Hindmarsh—Rose (HR) neuron model in many recent studies, which can interpret almost all of the previously simulated bifurcation processes with chaos in neural firing patterns. In the present paper, a comb-shaped chaotic region in a two-dimensional parameter space was reproduced, which presented different processes of period-adding bifurcations with chaos with changing one parameter and fixed the other parameter at different levels. In the biological experiments, different period-adding bifurcation scenarios with chaos by decreasing the extra-cellular calcium concentration were observed from some neural pacemakers at different levels of extra-cellular 4-aminopyridine concentration and from other pacemakers at different levels of extra-cellular caesium concentration. By using the nonlinear time series analysis method, the deterministic dynamics of the experimental chaotic firings were investigated. The period-adding bifurcations with chaos observed in the experiments resembled those simulated in the comb-shaped chaotic region using the HR model. The experimental results show that period-adding bifurcations with chaos are preserved in different two-dimensional parameter spaces, which provides evidence of the existence of the comb-shaped chaotic region and a demonstration of the simulation results in different two-dimensional parameter spaces in the HR neuron model. The results also present relationships between different firing patterns in two-dimensional parameter spaces.

Geographic differences in perioperative opioid administration in children

PubMed Central

Rabbitts, Jennifer A.; Groenewald, Cornelius B.; Räsänen, Jukka

2012-01-01

Objectives To investigate whether geographic differences exist in perioperative opioid administration to children. Aim To investigate whether perioperative fentanyl use for cleft lip and palate surgery varies between children of three different geographic regions. Background Differences have been found in perioperative opioid administration to children of differing ethnicity in the U.S.A. Whether similar differences exist in perioperative opioid administration to children residing in different geographic regions is unknown. Methods/materials We retrospectively reviewed the medical records of ASA I children who underwent surgery under standardized general anesthesia between January 2010 and April 2011 during SMILE Network International mission trips to Africa, India and Central and South America. Perioperative administration of fentanyl was compared between these three locations. Results We analyzed data from 79 children who underwent surgery in Africa, 76 in India and 153 in Central and South America. Children in Central and South America were given less than 50% of the intraoperative amount of fentanyl (2.0 ± 1.2 mcg/kg) administered to children in Africa (4.1 ± 2.4 mcg/kg; p<0.001) and children in India (4.3 ± 2.2 mcg/kg; p < 0.001). Postoperatively, fentanyl was administered in equivalent doses to all groups. Conclusions Children in Central and South America received less opioid intraoperatively than African and Indian children, under standardized anesthesia for cleft surgeries. Further research is necessary to elucidate the mechanisms underlying these group differences. PMID:22324378

[Obstacle factors in implementation of integrated schistosomiasis prevention and control strategies with emphasis on infectious source in hilly endemic regions].

PubMed

Xu, Jia; Chen, Lin; Zhang, Yi; Wu, Jian-Jun; Wan, Xue-Xiang; Zhu, Rong; Xu, Hui-Rong; Liu, Qing; Huang, Liang; Wu, Zi-Song; Lu, Long-Ting; Zhong, Bo

2013-12-01

To analyze the main obstacles existing in the implementation of integrated schistosomiasis prevention and control strategies with emphasis on infection source in hilly endemic regions, and to find out the current priority issues in schistosomiasis prevention and control, so as to provide the evidence for further solutions. Two typical hilly schistosomiasis endemic regions in Sichuan Province, including Pujiang County of Chengdu City and Dongpo District of Meishan City, were selected as research areas. A framework of obstacle factors in the implementation of integrated schistosomiasis prevention and control strategies with emphasis on infectious source in hilly endemic regions was built by literature review, and the management and technical personnel who worked on schistosomiasis prevention and control in eight different industries (health, agriculture, forestry and so on) and five levels (provincial, city, county, township and village levels) were investigated by questionnaires in the way of nominal group. One hundred and fifty-three management and technical personnel in different industries and different levels were investigated. The questionnaire recovery rate (experts' positive coefficient) was 100%. The results showed that the first four problems needing to be concerned in the implementation of integrated schistosomiasis prevention and control strategies with emphasis on infection source were eliminating Oncomelania hupensis snails by projects, health education, examination and treatment for schistosomiasis persons, and harmless treatment of night-soil and safe water supply. The focuses of two counties in the implementation of integrated strategy measures were different. The harmless treatment of night-soil and safe water supply was the most important measure in Pujiang County, while the elimination of snails by projects was the most in Dong-po District. As the differences in the situation of epidemic areas and the existed condition of the prevention and treatment progress, the comprehensive schistosomiasis control measures should be adjusted according to the local conditions in the implementation of integrated schistosomiasis prevention and control strategies with emphasis on infection source.

Understanding the genetic diversity and population structure of yam (Dioscorea alata L.) using microsatellite markers

PubMed Central

Arnau, Gemma; MN, Sheela; Chair, Hana; Lebot, Vincent; K, Abraham; Perrier, Xavier; Petro, Dalila; Penet, Laurent; Pavis, Claudie

2017-01-01

Yams (Dioscorea sp.) are staple food crops for millions of people in tropical and subtropical regions. Dioscorea alata, also known as greater yam, is one of the major cultivated species and most widely distributed throughout the tropics. Despite its economic and cultural importance, very little is known about its origin, diversity and genetics. As a consequence, breeding efforts for resistance to its main disease, anthracnose, have been fairly limited. The objective of this study was to contribute to the understanding of D. alata genetic diversity by genotyping 384 accessions from different geographical regions (South Pacific, Asia, Africa and the Caribbean), using 24 microsatellite markers. Diversity structuration was assessed via Principal Coordinate Analysis, UPGMA analysis and the Bayesian approach implemented in STRUCTURE. Our results revealed the existence of a wide genetic diversity and a significant structuring associated with geographic origin, ploidy levels and morpho-agronomic characteristics. Seventeen major groups of genetically close cultivars have been identified, including eleven groups of diploid cultivars, four groups of triploids and two groups of tetraploids. STRUCTURE revealed the existence of six populations in the diploid genetic pool and a few admixed cultivars. These results will be very useful for rationalizing D. alata genetic resources in breeding programs across different regions and for improving germplasm conservation methods. PMID:28355293

Crustal structure in high deformation zones: Insights from gravimetric and magnetometric studies in the Guacha Corral shear zone (Eastern Sierras Pampeanas, Argentina)

NASA Astrophysics Data System (ADS)

Radice, Stefania; Lince Klinger, Federico; Maffini, M. Natalia; Pinotti, Lucio P.; Demartis, Manuel; D´Eramo, Fernando J.; Giménez, Mario; Coniglio, Jorge E.

2018-03-01

The Guacha Corral shear zone (GCSZ) is represented by mylonites that were developed under amphibolites facies conditions from migmatitic protoliths. In this contribution, geophysical, petrological and structural data were combined to determine the 3D geometry of the GCSZ. New gravimetric, magnetometric and structural studies, along an E-W profile, were integrated with existing magnetotelluric and seismological data from a representative regional database of the Eastern Sierras Pampeanas. The zonation of different fabrics across the GCSZ suggests that the pre-existing heterogeneities of the protoliths played a key role in governing the degree of metamorphism of different regions. The low gravity anomalies observed in the GCSZ suggest a transitional boundary zone between the migmatitic and mylonitic domains, where highly deformed shear bands are interspersed with undeformed rocks, presenting gradual contacts. The mylonites in this shear zone show a considerably reduced density when compared to the migmatite protoliths. The density of the rocks gradually increases with depth until it reaches that of the protolith. These changes in the gravity values in response to density changes allowed us to infer a listric geometry at depth of the GCSZ. Low gravity anomalies in the profiles, in regions where high density rocks (migmatites) outcrop at the surface, modeled as buried granitic plutons.

Integration of color, orientation, and size functional domains in the ventral pathway

PubMed Central

Ghose, Geoffrey M.; Ts’o, Daniel Y.

2017-01-01

Abstract. Functional specialization within the extrastriate areas of the ventral pathway associated with visual form analysis is poorly understood. Studies comparing the functional selectivities of neurons within the early visual areas have found that there are more similar than different between the areas. We simultaneously imaged visually evoked activation over regions of V2 and V4 and parametrically varied three visual attributes for which selectivity exists in both areas: color, orientation, and size. We found that color selective regions were observed in both areas and were of similar size and spatial distribution. However, two major areal distinctions were observed: V4 contained a greater number and diversity of color-specific regions than V2 and exhibited a higher degree of overlap between domains for different functional attributes. In V2, size and color regions were largely segregated from orientation domains, whereas in V4 both color and size regions overlapped considerably with orientation regions. Our results suggest that higher-order composite selectivities in the extrastriate cortex may arise organically from the interactions afforded by an overlap of functional domains for lower order selectivities. PMID:28573155

EarthConnections: Integrating Community Science and Geoscience Education Pathways for More Resilient Communities.

NASA Astrophysics Data System (ADS)

Manduca, C. A.

2017-12-01

To develop a diverse geoscience workforce, the EarthConnections collective impact alliance is developing regionally focused, Earth education pathways. These pathways support and guide students from engagement in relevant, Earth-related science at an early age through the many steps and transitions to geoscience-related careers. Rooted in existing regional activities, pathways are developed using a process that engages regional stakeholders and community members with EarthConnections partners. Together they connect, sequence, and create multiple learning opportunities that link geoscience education and community service to address one or more local geoscience issues. Three initial pilots are demonstrating different starting points and strategies for creating pathways that serve community needs while supporting geoscience education. The San Bernardino pilot is leveraging existing academic relationships and programs; the Atlanta pilot is building into existing community activities; and the Oklahoma Tribal Nations pilot is co-constructing a pathway focus and approach. The project is using pathway mapping and a collective impact framework to support and monitor progress. The goal is to develop processes and activities that can help other communities develop similar community-based geoscience pathways. By intertwining Earth education with local community service we aspire to increase the resilience of communities in the face of environmental hazards and limited Earth resources.

A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidase

PubMed Central

Qin, Zhen; Xiao, Yibei; Yang, Xinbin; Mesters, Jeroen R.; Yang, Shaoqing; Jiang, Zhengqiang

2015-01-01

Glycoside hydrolase (GH) family 3 β-N-acetylglucosaminidases widely exist in the filamentous fungi, which may play a key role in chitin metabolism of fungi. A multi-domain GH family 3 β-N-acetylglucosaminidase from Rhizomucor miehei (RmNag), exhibiting a potential N-acetyltransferase region, has been recently reported to show great potential in industrial applications. In this study, the crystal structure of RmNag was determined at 2.80 Å resolution. The three-dimensional structure of RmNag showed four distinctive domains, which belong to two distinguishable functional regions — a GH family 3 β-N-acetylglucosaminidase region (N-terminal) and a N-acetyltransferase region (C-terminal). From structural and functional analysis, the C-terminal region of RmNag was identified as a unique tandem array linking general control non-derepressible 5 (GCN5)-related N-acetyltransferase (GNAT), which displayed glucosamine N-acetyltransferase activity. Structural analysis of this glucosamine N-acetyltransferase region revealed that a unique glucosamine binding pocket is located in the pantetheine arm binding terminal region of the conserved CoA binding pocket, which is different from all known GNAT members. This is the first structural report of a glucosamine N-acetyltransferase, which provides novel structural information about substrate specificity of GNATs. The structural and functional features of this multi-domain β-N-acetylglucosaminidase could be useful in studying the catalytic mechanism of GH family 3 proteins. PMID:26669854

A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidase.

PubMed

Qin, Zhen; Xiao, Yibei; Yang, Xinbin; Mesters, Jeroen R; Yang, Shaoqing; Jiang, Zhengqiang

2015-12-16

Glycoside hydrolase (GH) family 3 β-N-acetylglucosaminidases widely exist in the filamentous fungi, which may play a key role in chitin metabolism of fungi. A multi-domain GH family 3 β-N-acetylglucosaminidase from Rhizomucor miehei (RmNag), exhibiting a potential N-acetyltransferase region, has been recently reported to show great potential in industrial applications. In this study, the crystal structure of RmNag was determined at 2.80 Å resolution. The three-dimensional structure of RmNag showed four distinctive domains, which belong to two distinguishable functional regions--a GH family 3 β-N-acetylglucosaminidase region (N-terminal) and a N-acetyltransferase region (C-terminal). From structural and functional analysis, the C-terminal region of RmNag was identified as a unique tandem array linking general control non-derepressible 5 (GCN5)-related N-acetyltransferase (GNAT), which displayed glucosamine N-acetyltransferase activity. Structural analysis of this glucosamine N-acetyltransferase region revealed that a unique glucosamine binding pocket is located in the pantetheine arm binding terminal region of the conserved CoA binding pocket, which is different from all known GNAT members. This is the first structural report of a glucosamine N-acetyltransferase, which provides novel structural information about substrate specificity of GNATs. The structural and functional features of this multi-domain β-N-acetylglucosaminidase could be useful in studying the catalytic mechanism of GH family 3 proteins.

Assessment of CORDEX-South Asia experiments for monsoonal precipitation over Himalayan region for future climate

NASA Astrophysics Data System (ADS)

Choudhary, A.; Dimri, A. P.

2018-04-01

Precipitation is one of the important climatic indicators in the global climate system. Probable changes in monsoonal (June, July, August and September; hereafter JJAS) mean precipitation in the Himalayan region for three different greenhouse gas emission scenarios (i.e. representative concentration pathways or RCPs) and two future time slices (near and far) are estimated from a set of regional climate simulations performed under Coordinated Regional Climate Downscaling Experiment-South Asia (CORDEX-SA) project. For each of the CORDEX-SA simulations and their ensemble, projections of near future (2020-2049) and far future (2070-2099) precipitation climatology with respect to corresponding present climate (1970-2005) over Himalayan region are presented. The variability existing over each of the future time slices is compared with the present climate variability to determine the future changes in inter annual fluctuations of monsoonal mean precipitation. The long-term (1970-2099) trend (mm/day/year) of monsoonal mean precipitation spatially distributed as well as averaged over Himalayan region is analyzed to detect any change across twenty-first century as well as to assess model uncertainty in simulating the precipitation changes over this period. The altitudinal distribution of difference in trend of future precipitation from present climate existing over each of the time slices is also studied to understand any elevation dependency of change in precipitation pattern. Except for a part of the Hindu-Kush area in western Himalayan region which shows drier condition, the CORDEX-SA experiments project in general wetter/drier conditions in near future for western/eastern Himalayan region, a scenario which gets further intensified in far future. Although, a gradually increasing precipitation trend is seen throughout the twenty-first century in carbon intensive scenarios, the distribution of trend with elevation presents a very complex picture with lower elevations showing a greater trend in far-future under RCP8.5 when compared with higher elevations.

A Study on the Nonmetallic Inclusion Motions in a Swirling Flow Submerged Entry Nozzle in a New Cylindrical Tundish Design

NASA Astrophysics Data System (ADS)

Ni, Peiyuan; Ersson, Mikael; Jonsson, Lage Tord Ingemar; Jönsson, Pär Göran

2018-04-01

Different sizes and shapes of nonmetallic inclusions in a swirling flow submerged entry nozzle (SEN) placed in a new tundish design were investigated by using a Lagrangian particle tracking scheme. The results show that inclusions in the current cylindrical tundish have difficulties remaining in the top tundish region, since a strong rotational steel flow exists in this region. This high rotational flow of 0.7 m/s provides the required momentum for the formation of a strong swirling flow inside the SEN. The results show that inclusions larger than 40 µm were found to deposit to a smaller extent on the SEN wall compared to smaller inclusions. The reason is that these large inclusions have Separation number values larger than 1. Thus, the swirling flow causes these large size inclusions to move toward the SEN center. For the nonspherical inclusions, large size inclusions were found to be deposited on the SEN wall to a larger extent, compared to spherical inclusions. More specifically, the difference of the deposited inclusion number is around 27 pct. Overall, it was found that the swirling flow contains three regions, namely, the isotropic core region, the anisotropic turbulence region and the near-wall region. Therefore, anisotropic turbulent fluctuations should be taken into account when the inclusion motion was tracked in this complex flow. In addition, many inclusions were found to deposit at the SEN inlet region. The plotted velocity distribution shows that the inlet flow is very chaotic. A high turbulent kinetic energy value of around 0.08 m2/s2 exists in this region, and a recirculating flow was also found here. These flow characteristics are harmful since they increase the inclusion transport toward the wall. Therefore, a new design of the SEN inlet should be developed in the future, with the aim to modify the inlet flow so that the inclusion deposition is reduced.

International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short-term outcomes in patients enrolled in Eastern Europe and Russia in the PROTECT trial

PubMed Central

Mentz, Robert J.; Cotter, Gad; Cleland, John G.F.; Stevens, Susanna R.; Chiswell, Karen; Davison, Beth A.; Teerlink, John R.; Metra, Marco; Voors, Adriaan A.; Grinfeld, Liliana; Ruda, Mikhail; Mareev, Viacheslav; Lotan, Chaim; Bloomfield, Daniel M.; Fiuzat, Mona; Givertz, Michael M.; Ponikowski, Piotr; Massie, Barry M.; O’Connor, Christopher M.

2017-01-01

Aims The implications of geographical variation are unknown following adjustment for hospital length of stay (LOS) in heart failure (HF) trials that included patients whether or not they had systolic dysfunction. We investigated regional differences in an international acute HF trial. Methods and results The PROTECT trial investigated 2033 patients with acute HF and renal dysfunction hospitalized at 173 sites in 17 countries with randomization to rolofylline or placebo. We grouped enrolling countries into six regions. Baseline characteristics, in-hospital management, and outcomes were explored by region. The primary study outcome was 60-day mortality or cardiovascular/renal hospitalization. Secondary outcomes included 180-day mortality. Of 2033 patients, 33% were from Eastern Europe, 19% from Western Europe, 16% from Israel, 15% from North America, 14% from Russia, and 3% from Argentina. Marked differences in baseline characteristics, HF phenotype, in-hospital diuretic and vasodilator strategies, and LOS were observed by region. LOS was shortest in North America and Israel (median 5 days) and longest in Russia (median 15 days). Regional event rates varied significantly. Following multivariable adjustment, region was an independent predictor of the risk of mortality/hospitalization at 60 days, with the lowest risk in Russia (hazard ratio 0.39, 95% confidence interval 0.23–0.64 vs. Western Europe) due to lower rehospitalization; mortality differences were attenuated by 180 days. Conclusions In an international HF trial, there were differences in baseline characteristics, treatments, LOS, and rehospitalization amongst regions, but little difference in longer term mortality. Rehospitalization differences exist independent of LOS. This analysis may help inform future trial design and should be externally validated. PMID:24771609

Distribution of sea anemones (Cnidaria, Actiniaria) in Korea analyzed by environmental clustering

USGS Publications Warehouse

Cha, H.-R.; Buddemeier, R.W.; Fautin, D.G.; Sandhei, P.

2004-01-01

Using environmental data and the geospatial clustering tools LOICZView and DISCO, we empirically tested the postulated existence and boundaries of four biogeographic regions in the southern part of the Korean peninsula. Environmental variables used included wind speed, sea surface temperature (SST), salinity, tidal amplitude, and the chlorophyll spectral signal. Our analysis confirmed the existence of four biogeographic regions, but the details of the borders between them differ from those previously postulated. Specimen-level distribution records of intertidal sea anemones were mapped; their distribution relative to the environmental data supported the importance of the environmental parameters we selected in defining suitable habitats. From the geographic coincidence between anemone distribution and the clusters based on environmental variables, we infer that geospatial clustering has the power to delimit ranges for marine organisms within relatively small geographical areas.

A comparison of regional flood frequency analysis approaches in a simulation framework

NASA Astrophysics Data System (ADS)

Ganora, D.; Laio, F.

2016-07-01

Regional frequency analysis (RFA) is a well-established methodology to provide an estimate of the flood frequency curve at ungauged (or scarcely gauged) sites. Different RFA approaches exist, depending on the way the information is transferred to the site of interest, but it is not clear in the literature if a specific method systematically outperforms the others. The aim of this study is to provide a framework wherein carrying out the intercomparison by building up a virtual environment based on synthetically generated data. The considered regional approaches include: (i) a unique regional curve for the whole region; (ii) a multiple-region model where homogeneous subregions are determined through cluster analysis; (iii) a Region-of-Influence model which defines a homogeneous subregion for each site; (iv) a spatially smooth estimation procedure where the parameters of the regional model vary continuously along the space. Virtual environments are generated considering different patterns of heterogeneity, including step change and smooth variations. If the region is heterogeneous, with the parent distribution changing continuously within the region, the spatially smooth regional approach outperforms the others, with overall errors 10-50% lower than the other methods. In the case of a step-change, the spatially smooth and clustering procedures perform similarly if the heterogeneity is moderate, while clustering procedures work better when the step-change is severe. To extend our findings, an extensive sensitivity analysis has been performed to investigate the effect of sample length, number of virtual stations, return period of the predicted quantile, variability of the scale parameter of the parent distribution, number of predictor variables and different parent distribution. Overall, the spatially smooth approach appears as the most robust approach as its performances are more stable across different patterns of heterogeneity, especially when short records are considered.

Small-worldness and gender differences of large scale brain metabolic covariance networks in young adults: a FDG PET study of 400 subjects.

PubMed

Hu, Yuxiao; Xu, Qiang; Shen, Junkang; Li, Kai; Zhu, Hong; Zhang, Zhiqiang; Lu, Guangming

2015-02-01

Many studies have demonstrated the small-worldness of the human brain, and have revealed a sexual dimorphism in brain network properties. However, little is known about the gender effects on the topological organization of the brain metabolic covariance networks. To investigate the small-worldness and the gender differences in the topological architectures of human brain metabolic networks. FDG-PET data of 400 healthy right-handed subjects (200 women and 200 age-matched men) were involved in the present study. Metabolic networks of each gender were constructed by calculating the covariance of regional cerebral glucose metabolism (rCMglc) across subjects on the basis of AAL parcellation. Gender differences of network and nodal properties were investigated by using the graph theoretical approaches. Moreover, the gender-related difference of rCMglc in each brain region was tested for investigating the relationships between the hub regions and the brain regions showing significant gender-related differences in rCMglc. We found prominent small-world properties in the domain of metabolic networks in each gender. No significant gender difference in the global characteristics was found. Gender differences of nodal characteristic were observed in a few brain regions. We also found bilateral and lateralized distributions of network hubs in the females and males. Furthermore, we first reported that some hubs of a gender located in the brain regions showing weaker rCMglc in this gender than the other gender. The present study demonstrated that small-worldness was existed in metabolic networks, and revealed gender differences of organizational patterns in metabolic network. These results maybe provided insights into the understanding of the metabolic substrates underlying individual differences in cognition and behaviors. © The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain.

PubMed

Chang, Mengqi; Lv, Hongyi; Zhang, Weilong; Ma, Chunhui; He, Xue; Zhao, Shunli; Zhang, Zhi-Wei; Zeng, Yi-Xin; Song, Shuhui; Niu, Yamei; Tong, Wei-Min

2017-09-01

N 6 -methyladenosine (m 6 A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m 6 A levels in the brain, its potential functions in the brain remain largely unexplored. We performed a transcriptome-wide methylation analysis using the mouse brain to depict its region-specific methylation profile. RNA methylation levels in mouse cerebellum are generally higher than those in the cerebral cortex. Heterogeneity of RNA methylation exists across different brain regions and different types of neural cells including the mRNAs to be methylated, their methylation levels and methylation site selection. Common and region-specific methylation have different preferences for methylation site selection and thereby different impacts on their biological functions. In addition, high methylation levels of fragile X mental retardation protein (FMRP) target mRNAs suggest that m 6 A methylation is likely to be used for selective recognition of target mRNAs by FMRP in the synapse. Overall, we provide a region-specific map of RNA m 6 A methylation and characterize the distinct features of specific and common methylation in mouse cerebellum and cerebral cortex. Our results imply that RNA m 6 A methylation is a newly identified element in the region-specific gene regulatory network in the mouse brain. © 2017 The Authors.

REGIONAL BINNING FOR CONTINUED STORAGE OF SPENT NUCLEAR FUEL AND HIGH-LEVEL WASTES

DOE Office of Scientific and Technical Information (OSTI.GOV)

W. Lee Poe, Jr

1998-10-01

In the Continued Storage Analysis Report (CSAR) (Reference 1), DOE decided to analyze the environmental consequences of continuing to store the commercial spent nuclear fuel (SNF) at 72 commercial nuclear power sites and DOE-owned spent nuclear fuel and high-level waste at five Department of Energy sites by region rather than by individual site. This analysis assumes that three commercial facilities pairs--Salem and Hope Creek, Fitzpatrick and Nine-Mile Point, and Dresden and Moms--share common storage due to their proximity to each other. The five regions selected for this analysis are shown on Figure 1. Regions 1, 2, and 3 are themore » same as those used by the Nuclear Regulatory Commission in their regulatory oversight of commercial power reactors. NRC Region 4 was subdivided into two regions to more appropriately define the two different climates that exist in NRC Region 4. A single hypothetical site in each region was assumed to store all the SNF and HLW in that region. Such a site does not exist and has no geographic location but is a mathematical construct for analytical purposes. To ensure that the calculated results for the regional analyses reflect appropriate inventory, facility and material degradation, and radionuclide transport, the waste inventories, engineered barriers, and environmental conditions for the hypothetical sites were developed from data for each of the existing sites within the given region. Weighting criteria to account for the amount and types of SNF and HLW at each site were used in the development of the environmental data for the regional site, such that the results of the analyses for the hypothetical site were representative of the sum of the results of each actual site if they had been modeled independently. This report defines the actual site data used in development of this hypothetical site, shows how the individual site data was weighted to develop the regional site, and provides the weighted data used in the CSAR analysis. It is divided into Part 1 that defines time-dependent releases from each regional site, Part 2 that defines transport conditions through the groundwater, and Part 3 that defines transport through surface water and populations using the surface waters for drinking.« less

A transitional volume beneath the Sannio-Irpinia border region (southern Apennines): Different tectonic styles at different depths

NASA Astrophysics Data System (ADS)

De Matteo, Ada; Massa, Bruno; Milano, Girolamo; D'Auria, Luca

2018-01-01

In this paper we investigate the border between the Sannio and Irpinia seismogenic regions, a sector of the southern Apennine chain considered among the most active seismic areas of the Italian peninsula, to shed further light on its complex seismotectonic setting. We integrated recent seismicity with literature data. A detailed analysis of the seismicity that occurred in the 2013-2016 time interval was performed. The events were relocated, after manual re-picking, using different approaches. To retrieve information about the stress field active in the area, inversion of Fault Plane Solutions was also carried out. Hypocentral distribution of the relocated events (ML ≤ 3.5), whose depth is included between 5 and 25 km with the deepest ones located in the NW sector of the study area, shows a different pattern between the northern sector and the southern one. The computed Fault Plane Solutions can be grouped in three depth ranges: < 12 km, dominated by normal dip-slip kinematics; 12-18 km, characterized by normal dip-slip and strike-slip kinematics; > 18 km, dominated by strike-slip kinematics. Stress field inversion across the whole area shows that we are dealing with an heterogeneous set of data, apparently governed by distinct stress fields. We built an upper crustal model profile through integration of geological data, well logs and seismic tomographic profiles. Our results suggest the co-existence of different tectonic styles at distinct crustal depths: the upper crust seems to be affected mostly by normal faulting, whereas strike-slip faulting prevails in the intermediate and lower crust. We infer about the existence of a transitional volume, located between 12 and 18 km depth, between the Sannio and Irpinia regions, acting as a vertical transfer zone.

Inequality and mortality: demographic hypotheses regarding advanced and peripheral capitalism.

PubMed

Gregory, J W; Piché, V

1983-01-01

This paper analyzes mortality differences between social classes and between advanced and peripheral regions of the world economy. The demographic analysis of mortality is integrated with the study of political economy, which emphasizes the entire process of social reproduction. As part of this dialectic model, both the struggle of the working class to improve health and the interest of capital in maximizing profits are examined. Data from Québec and Upper Volta are used to illustrate the hypothesis that substantially higher mortality rates exist for the working class compared with the bourgeoisie and in the less developed peripheral regions compared with the more developed regions.

Lateral fluid flow in a compacting sand-shale sequence: South Caspian basin.

USGS Publications Warehouse

Bredehoeft, J.D.; Djevanshir, R.D.; Belitz, K.R.

1988-01-01

The South Caspian basin contains both sands and shales that have pore-fluid pressures substantially in excess of hydrostatic fluid pressure. Pore-pressure data from the South Caspian basin demonstrate that large differences in excess hydraulic head exist between sand and shale. The data indicate that sands are acting as drains for overlying and underlying compacting shales and that fluid flows laterally through the sand on a regional scale from the basin interior northward to points of discharge. The major driving force for the fluid movement is shale compaction. We present a first- order mathematical analysis in an effort to test if the permeability of the sands required to support a regional flow system is reasonable. The results of the analysis suggest regional sand permeabilities ranging from 1 to 30 md; a range that seems reasonable. This result supports the thesis that lateral fluid flow is occurring on a regional scale within the South Caspian basin. If vertical conduits for flow exist within the basin, they are sufficiently impermeable and do not provide a major outlet for the regional flow system. The lateral fluid flow within the sands implies that the stratigraphic sequence is divided into horizontal units that are hydraulically isolated from one another, a conclusion that has important implications for oil and gas migration.-Authors

Towards life cycle sustainability assessent of cities. A review of background knowledge.

PubMed

Albertí, Jaume; Balaguera, Alejandra; Brodhag, Christian; Fullana-I-Palmer, Pere

2017-12-31

This article analyses whether existing LCA and sustainability methods can be used in the assessment of a city or an urban region. The approach is performed through the review of current existing LCA-based and sustainability standards and guidelines. A focus is put into those LCA-based standards specially designed for the built environment. Moreover, a review of non-LCA based standards, indices and guides for the assessment of the sustainability of countries, cities or urban regions is done. The purpose is to check if these assessment tools can provide good results in the absence of LCA-based assessments for cities and urban regions. This review demonstrates the lack of consensus in the definition of both, the city and its boundaries, which hinders the development of useful sustainability standards. Furthermore, it is concluded that current sustainability assessment tools miss, at least, one of these aspects: (i) holistic point of view, (ii) focus on various environmental impacts, (iii) a Life Cycle (LC) perspective, and (iv) the possibility to compare the results among different cities or urban regions. From the LCA perspective, the deficiencies found also include the need for a definition of the function, functional unit (FU), and reference flow (RF) of neighbourhoods, cities, and urban regions. Copyright © 2017 Elsevier B.V. All rights reserved.

Nowcasting Aircraft Icing Conditions in Moscow Region Using Geostationary Meteorological Satellite Data

NASA Astrophysics Data System (ADS)

Barabanova, Olga

2013-04-01

Nowadays the Main Aviation Meteorological Centre in Moscow (MAMC) provides forecasts of icing conditions in Moscow Region airports using information of surface observation network, weather radars and atmospheric sounding. Unfortunately, satellite information is not used properly in aviation meteorological offices in Moscow Region: weather forecasters deal with satellites images of cloudiness only. The main forecasters of MAMC realise that it is necessary to employ meteorological satellite numerical data from different channels in aviation forecasting and especially in nowcasting. Algorithm of nowcasting aircraft in-flight icing conditions has been developed using data from geostationary meteorological satellites "Meteosat-7" and "Meteosat-9". The algorithm is based on the brightness temperature differences. Calculation of brightness temperature differences help to discriminate clouds with supercooled large drops where severe icing conditions are most likely. Due to the lack of visible channel data, the satellite icing detection methods will be less accurate at night. Besides this method is limited by optically thick ice clouds where it is not possible to determine the extent to which supercooled large drops exists within the underlying clouds. However, we determined that most of the optically thick cases are associated with convection or mid-latitude cyclones and they will nearly always have a layer where which supercooled large drops exists with an icing threat. This product is created hourly for the Moscow Air Space and mark zones with moderate or severe icing hazards. The results were compared with mesoscale numerical atmospheric model COSMO-RU output. Verification of the algorithms results using aircraft pilot reports shows that this algorithm is a good instrument for the operational practise in aviation meteorological offices in Moscow Region. The satellite-based algorithms presented here can be used in real time to diagnose areas of icing for pilots to avoid.

Setting Priorities for Regional Conservation Planning in the Mediterranean Sea

PubMed Central

Micheli, Fiorenza; Levin, Noam; Giakoumi, Sylvaine; Katsanevakis, Stelios; Abdulla, Ameer; Coll, Marta; Fraschetti, Simonetta; Kark, Salit; Koutsoubas, Drosos; Mackelworth, Peter; Maiorano, Luigi; Possingham, Hugh P.

2013-01-01

Spatial prioritization in conservation is required to direct limited resources to where actions are most urgently needed and most likely to produce effective conservation outcomes. In an effort to advance the protection of a highly threatened hotspot of marine biodiversity, the Mediterranean Sea, multiple spatial conservation plans have been developed in recent years. Here, we review and integrate these different plans with the goal of identifying priority conservation areas that represent the current consensus among the different initiatives. A review of six existing and twelve proposed conservation initiatives highlights gaps in conservation and management planning, particularly within the southern and eastern regions of the Mediterranean and for offshore and deep sea habitats. The eighteen initiatives vary substantially in their extent (covering 0.1–58.5% of the Mediterranean Sea) and in the location of additional proposed conservation and management areas. Differences in the criteria, approaches and data used explain such variation. Despite the diversity among proposals, our analyses identified ten areas, encompassing 10% of the Mediterranean Sea, that are consistently identified among the existing proposals, with an additional 10% selected by at least five proposals. These areas represent top priorities for immediate conservation action. Despite the plethora of initiatives, major challenges face Mediterranean biodiversity and conservation. These include the need for spatial prioritization within a comprehensive framework for regional conservation planning, the acquisition of additional information from data-poor areas, species or habitats, and addressing the challenges of establishing transboundary governance and collaboration in socially, culturally and politically complex conditions. Collective prioritised action, not new conservation plans, is needed for the north, western, and high seas of the Mediterranean, while developing initial information-based plans for the south and eastern Mediterranean is an urgent requirement for true regional conservation planning. PMID:23577060

The socio-economic landscape of biotechnology in Spain. A comparative study using the innovation system concept.

PubMed

Díaz, V; Muñoz, E; de los Monteros, J Espinosa; Senker, Jacqueline

2002-09-11

Biotechnology is becoming a crucial factor for the innovation strategies of the industrialised countries. Thus, the analysis of the sector is gaining relevance for the identification of the technological strength and potential of a country (or region) in a context of globalisation. A specific national case study may serve for more general comparative analyses. We have selected the case of Spain as illustrative of the complexity and differences existing in Europe. By using the analytical framework of the "national systems of innovation" concept, we have performed a multistep analysis of the biotechnology sector in Spain, focussing first on regions of Madrid and Cataluña which together account for more than 50% of the sector in Spain. The firms in both regions have followed a common strategy based on diversification and investment in R&D and innovation, so as to be able to compete in an international and competitive environment. There are, however, some interesting differences between the two subsectors; the one from Cataluña being more based on industrial traditions, and the one from Madrid characterised by the emergence of more specialised firms. The study has been extended to the remainder of Spanish firms for comparative purposes. The case of Spain is illustrative of the divergences existing in the biotechnology sector in Europe. A comparison is made with the structural and organisational characteristics of the biotechnology sector in several European countries. It shows that there is diversity in the pattern of commercialisation between countries and within regions of countries. Understanding these differences may assist the design of appropriate policies to promote the development of biotechnology in Europe.

Major Histocompatibility Complex Genes Map to Two Chromosomes in an Evolutionarily Ancient Reptile, the Tuatara Sphenodon punctatus.

PubMed

Miller, Hilary C; O'Meally, Denis; Ezaz, Tariq; Amemiya, Chris; Marshall-Graves, Jennifer A; Edwards, Scott

2015-05-07

Major histocompatibility complex (MHC) genes are a central component of the vertebrate immune system and usually exist in a single genomic region. However, considerable differences in MHC organization and size exist between different vertebrate lineages. Reptiles occupy a key evolutionary position for understanding how variation in MHC structure evolved in vertebrates, but information on the structure of the MHC region in reptiles is limited. In this study, we investigate the organization and cytogenetic location of MHC genes in the tuatara (Sphenodon punctatus), the sole extant representative of the early-diverging reptilian order Rhynchocephalia. Sequencing and mapping of 12 clones containing class I and II MHC genes from a bacterial artificial chromosome library indicated that the core MHC region is located on chromosome 13q. However, duplication and translocation of MHC genes outside of the core region was evident, because additional class I MHC genes were located on chromosome 4p. We found a total of seven class I sequences and 11 class II β sequences, with evidence for duplication and pseudogenization of genes within the tuatara lineage. The tuatara MHC is characterized by high repeat content and low gene density compared with other species and we found no antigen processing or MHC framework genes on the MHC gene-containing clones. Our findings indicate substantial differences in MHC organization in tuatara compared with mammalian and avian MHCs and highlight the dynamic nature of the MHC. Further sequencing and annotation of tuatara and other reptile MHCs will determine if the tuatara MHC is representative of nonavian reptiles in general. Copyright © 2015 Miller et al.

Human well-being differs by community type: Towards reference points in a human well-being indicator useful for decision support

EPA Science Inventory

Human activity has growing impacts on the natural capital humans depend on for existence. While many of these impacts are regional, national, or international in scope, it is increasingly evident that decisions made at the local community level are also important. Yet, understand...

Ground-Truthing Validation to Assess the Effect of Facility Locational Error on Cumulative Impacts Screening Tools

EPA Science Inventory

Over the past three decades, a number of researchers in the fields of environmental justice (EJ) and environmental public health have highlighted the existence of regional and local scale differences in exposure to air pollution, as well as calculated health risk and impacts of a...

Summarizing the Effect of a Wide Array of Amenity Measures into Simple Components

ERIC Educational Resources Information Center

Gunderson, Ronald J.; Ng, Pin T.

2006-01-01

A significant issue existing within the rural economic development literature revolves around the difficulty with sorting out the controversy of the effects of amenity activities on rural economic growth. This problem is due to the different ways amenity attributes are linked to regional economic performance. Numerous researchers utilize principal…

Nativity and nutritional behaviors in the Mexican origin population living in the US-Mexico border region.

PubMed

Montoya, Jared A; Salinas, Jennifer J; Barroso, Cristina S; Mitchell-Bennett, Lisa; Reininger, Belinda

2011-02-01

The purpose of this study is to determine the relationship between nativity and nutritional behaviors and beliefs in the Mexican American population living in the South Texas border region. Mexican Americans living the border region of South Texas were sampled to assess their nutrition behaviors and beliefs. Nativity was measured as whether subjects were born in the United States or Mexico. Nutritional behaviors were measured using the SPAN and indexes were used to measure barriers to good nutrition, dietary self-efficacy, and dietary importance. OLS regression analysis was used and adjustments were made for sociodemographic factors. Differences between US-born Mexican Americans and Mexico-born Mexican Americans existed in nutritional beliefs, but not in behaviors. Mexico-born Mexican Americans reported their dietary choices as more important and reported greater food self-efficacy than their US-born Mexican American counterparts. Socioeconomic status influenced US-born Mexican Americans nutritional beliefs only and the same effect was not observed for Mexico-born Mexican Americans. Despite low levels of overall acculturation in the border region dietary beliefs still exist between immigrants and US-born Mexican Americans in dietary beliefs, but, not behaviors in US-born Mexican Americans.

All Rural Places Are Not Created Equal: Revisiting the Rural Mortality Penalty in the United States

PubMed Central

2014-01-01

Objectives. I investigated mortality disparities between urban and rural areas by measuring disparities in urban US areas compared with 6 rural classifications, ranging from suburban to remote locales. Methods. Data from the Compressed Mortality File, National Center for Health Statistics, from 1968 to 2007, was used to calculate age-adjusted mortality rates for all rural and urban regions by year. Criteria measuring disparity between regions included excess deaths, annual rate of change in mortality, and proportion of excess deaths by population size. I used multivariable analysis to test for differences in determinants across regions. Results. The rural mortality penalty existed in all rural classifications, but the degree of disparity varied considerably. Rural–urban continuum code 6 was highly disadvantaged, and rural–urban continuum code 9 displayed a favorable mortality profile. Population, socioeconomic, and health care determinants of mortality varied across regions. Conclusions. A 2-decade long trend in mortality disparities existed in all rural classifications, but the penalty was not distributed evenly. This constitutes an important public health problem. Research should target the slow rates of improvement in mortality in the rural United States as an area of concern. PMID:25211763

[Variations among Spanish regions in the use of three cardiovascular technologies].

PubMed

Fitch-Warner, Kathryn; García de Yébenes, María J; Lázaro y de Mercado, Pablo; Belaza-Santurde, Javier

2006-12-01

There is evidence that some geographic variations in the use of medical technologies are not explained by differences in disease burden. The objectives of this study were to quantify variability in the use of percutaneous coronary intervention (PCI), implantable cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy (CRT) in Spanish autonomous regions and to try to explain the variability found for the first two technologies. Linear regression models were developed in which the number of procedures performed per million population (pmp) in 2003 in each autonomous region was the dependent variable. Independent variables used included indices of technology provision, regional wealth, and disease burden. For PCI, the mean utilization rate for the whole of Spain was 1038 procedures pmp, with a high-low ratio of 1.95. Differences in gross domestic product explained 21% of the variability, but there was no relationship between the number of procedures performed and disease burden. For ICDs, the mean number of procedures performed in the whole of Spain was 46 pmp, with a high-low ratio of 3.04. As for PCI, differences in regional wealth explained 40% of the variability, with disease burden making no contribution. For CRT, the mean number of procedures performed in Spain in 2003 was 15 pmp, with a high-low ratio of 15.7. The considerable regional variation that exists in the use of these three medical technologies is principally explained by differences in regional wealth and not in disease burden.

Intelligent transportation systems "ITS" : a strategic plan for the capitol region, executive summary

DOT National Transportation Integrated Search

1997-11-01

The ITS Strategic Plan outlines a strategy for improving the efficiency of the Capitol Regions existing highway and transit systems. The Regions overall goal is to improve the efficiency and effectiveness of existing systems so as to reduce the...

The Minor fall, the Major lift: inferring emotional valence of musical chords through lyrics

PubMed Central

Kolchinsky, Artemy; Dhande, Nakul; Park, Kengjeun

2017-01-01

We investigate the association between musical chords and lyrics by analysing a large dataset of user-contributed guitar tablatures. Motivated by the idea that the emotional content of chords is reflected in the words used in corresponding lyrics, we analyse associations between lyrics and chord categories. We also examine the usage patterns of chords and lyrics in different musical genres, historical eras and geographical regions. Our overall results confirm a previously known association between Major chords and positive valence. We also report a wide variation in this association across regions, genres and eras. Our results suggest possible existence of different emotional associations for other types of chords. PMID:29291089

Regional variation in mercury and stable isotopes of red snapper (Lutjanus campechanus) in the northern Gulf of Mexico, USA.

PubMed

Zapp Sluis, Michelle; Boswell, Kevin M; Chumchal, Matthew M; Wells, R J David; Soulen, Brianne; Cowan, James H

2013-02-01

The presence of total mercury (Hg) in fish tissue and the potential associated health risks has become a global concern in marine ecosystems. Few studies have examined basin-scale variation in Hg accumulation in marine ecosystems, and determining if Hg concentrations in fish tissue vary across marine ecosystems is a key monitoring question. The present study evaluated Hg concentrations in red snapper (Lutjanus campechanus) tissue across three regions of the northern Gulf of Mexico (Alabama, Louisiana, and Texas, USA) and between two habitat types (oil and gas platforms and nonplatforms) within each region. Nitrogen (δ(15)N), carbon (δ(13)C), and sulfur (δ(34)S) stable isotopes were used to investigate ecological differences that may affect Hg concentrations among regions and between habitats. Mercury concentrations in red snapper tissue were positively correlated with fish total length. Regional differences in Hg concentrations were significant, with fish collected from Alabama having the highest concentrations and fish collected from Louisiana having the lowest. No significant difference existed in Hg concentrations between habitats, suggesting that association with platforms may not be a significant factor contributing to red snapper Hg concentrations. While δ(15)N did not differ significantly among the three regions, Texas red snapper were more enriched in δ(34)S and depleted in δ(13)C compared with Alabama and Louisiana red snapper. Although the majority of red snapper collected in the present study had Hg concentrations below safe consumption guidelines, regional differences suggest that spatially explicit monitoring programs may be important for basin-wide assessments. Copyright © 2012 SETAC.

Analysis of the Co-existence of Long-range Transport Biomass Burning and Dust in the Subtropical West Pacific Region.

PubMed

Dong, Xinyi; Fu, Joshua S; Huang, Kan; Lin, Neng-Huei; Wang, Sheng-Hsiang; Yang, Cheng-En

2018-06-12

Biomass burning and wind-blown dust has been well investigated during the past decade regarding their impacts on environment, but their co-existence hasn't been recognized because they usually occur in different locations and episodes. In this study we reveal the unique co-existence condition that dust from the Taklamakan and Gobi Desert (TGD) and biomass burning from Peninsular Southeast Asia (PSEA) can reach to the west Pacific region simultaneously in boreal spring (March and April). The upper level trough at 700hPa along east coast of China favors the large scale subsidence of TGD dust while it travels southeastwards, and drives the PSEA biomass burning plume carried by the westerlies at 3-5 km to descend rapidly to around 1.5 km and mix with dust around southeast China and Taiwan. As compared to the monthly averages in March and April, surface observations suggested that concentrations of PM 10 , PM 2.5 , O 3 , and CO were 69%, 37%, 20%, and 18% higher respectively during the 10 identified co-existence events which usually lasted for 2-3 days. Co-existence also lowers the surface O 3 , NOx, and SO 2 by 4-5% due to the heterogeneous chemistry between biomass burning and mineral dust as indicated by model simulations.

Diffusion of innovations in social interaction systems. An agent-based model for the introduction of new drugs in markets.

PubMed

Pombo-Romero, Julio; Varela, Luis M; Ricoy, Carlos J

2013-06-01

The existence of imitative behavior among consumers is a well-known phenomenon in the field of Economics. This behavior is especially common in markets determined by a high degree of innovation, asymmetric information and/or price-inelastic demand, features that exist in the pharmaceutical market. This paper presents evidence of the existence of imitative behavior among primary care physicians in Galicia (Spain) when choosing treatments for their patients. From this and other evidence, we propose a dynamic model for determining the entry of new drugs into the market. To do this, we introduce the structure of the organization of primary health care centers and the presence of groups of doctors who are specially interrelated, as well as the existence of commercial pressure on doctors. For modeling purposes, physicians are treated as spins connected in an exponentially distributed complex network of the Watts-Strogatz type. The proposed model provides an explanation for the differences observed in the patterns of the introduction of technological innovations in different regions. The main cause of these differences is the different structure of relationships among consumers, where the existence of small groups that show a higher degree of coordination over the average is particularly influential. The evidence presented, together with the proposed model, might be useful for the design of optimal strategies for the introduction of new drugs, as well as for planning policies to manage pharmaceutical expenditure.

Conditions for the existence of Kelvin-Helmholtz instability in a CME

NASA Astrophysics Data System (ADS)

Jatenco-Pereira, Vera; Páez, Andrés; Falceta-Gonçalves, Diego; Opher, Merav

2015-08-01

The presence of Kelvin-Helmholtz instability (KHI) in the sheaths of the Coronal Mass Ejection (CME) has motivated several analysis and simulations to test their existence. In the present work we assume the existence of the KHI and propose a method to identify the regions where it is possible the development of KHI for a CME propagating in a fast and slow solar wind. We build functions for the velocities, densities and magnetic fields for two different zones of interaction between the solar wind and a CME. Based on the theory of magnetic KHI proposed by Chandrasekhar (1961) and we found conditions for the existence of KHI in the CME sheaths. Using this method it is possible to determine the range of parameters, in particular CME magnetic fields in which the KHI could exist. We conclude that KHI may exist in the two CME flanks and it is perceived that the zone with boundaries with the slow solar wind is more appropriated for the formation of the KHI.

Hybrid Viability and Fertility in Co-occuring Plant Species

NASA Astrophysics Data System (ADS)

Hernandez, E.; Garcia, C.; Yost, J.

2012-12-01

Similar species of plants can co-exist due to reproductive barriers that keep them from hybridizing. In the case of Lasthenia gracilis and L. californica, certain reproductive barriers allow them to co-exist at Jasper Ridge without hybridization. The two species are locally adapted to different regions of the same hillside, and have slight differences in flowering time but hybrids can be created at low rate in the green house. We tested the viability and fertility of green house produced hybrids to quantify post-zygotic reproductive isolation at Jasper Ridge. We planted 10 hybrid seeds and 10 control seeds from 11 different families. We measured the percent germination, survival to flowering and pollen fertility of the seeds. We expect lower germination, lower survival to flowering, and lower pollen viability of hybrid seeds as compared to control seeds.

Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2.

PubMed

Suetsugu, S; Miki, H; Yamaguchi, H; Obinata, T; Takenawa, T

2001-12-01

The actin-related protein (Arp) 2/3 complex is an essential regulator of de novo actin filament formation. Arp2/3 nucleates the polymerization of actin and creates branched actin filaments when activated by Arp2/3-complex activating domain (VCA) of Wiskott-Aldrich syndrome proteins (WASP family proteins). We found that the branching of actin filaments on pre-existing ADP filaments mediated by the Arp2/3 complex is twice as efficient when Arp2/3 was activated by wild-type neural WASP (N-WASP) or WASP-family verprolin-homologous protein (WAVE) 2 than when activated by the VCA domain alone. By contrast, there was no difference between wild-type N-WASP or WAVE2 and VCA in the branching efficiency on de novo filaments, which are thought to consist mainly of ADP-phosphate filaments. This increased branching efficiency on ADP filaments is due to the basic region located in the center of N-WASP and WAVE2, which was found to associate with ADP actin filaments. Actin filaments and phosphatidylinositol bisphosphate (PIP2) associate with N-WASP at different sites. This association of N-WASP and WAVE2 with actin filaments enhanced recruitment of Arp2/3 to the pre-existing filaments, presumably leading to efficient nucleation and branch formation on pre-existing filaments. These data together suggest that the actin filament binding activity of N-WASP and WAVE2 in the basic region increases the number of barbed ends created on pre-existing filaments. Efficient branching on ADP filaments may be important for initiation of actin-based motility.

Quantifying the potential for reservoirs to secure future surface water yields in the world’s largest river basins

NASA Astrophysics Data System (ADS)

Liu, Lu; Parkinson, Simon; Gidden, Matthew; Byers, Edward; Satoh, Yusuke; Riahi, Keywan; Forman, Barton

2018-04-01

Surface water reservoirs provide us with reliable water supply, hydropower generation, flood control and recreation services. Yet reservoirs also cause flow fragmentation in rivers and lead to flooding of upstream areas, thereby displacing existing land-use activities and ecosystems. Anticipated population growth and development coupled with climate change in many regions of the globe suggests a critical need to assess the potential for future reservoir capacity to help balance rising water demands with long-term water availability. Here, we assess the potential of large-scale reservoirs to provide reliable surface water yields while also considering environmental flows within 235 of the world’s largest river basins. Maps of existing cropland and habitat conservation zones are integrated with spatially-explicit population and urbanization projections from the Shared Socioeconomic Pathways to identify regions unsuitable for increasing water supply by exploiting new reservoir storage. Results show that even when maximizing the global reservoir storage to its potential limit (∼4.3–4.8 times the current capacity), firm yields would only increase by about 50% over current levels. However, there exist large disparities across different basins. The majority of river basins in North America are found to gain relatively little firm yield by increasing storage capacity, whereas basins in Southeast Asia display greater potential for expansion as well as proportional gains in firm yield under multiple uncertainties. Parts of Europe, the United States and South America show relatively low reliability of maintaining current firm yields under future climate change, whereas most of Asia and higher latitude regions display comparatively high reliability. Findings from this study highlight the importance of incorporating different factors, including human development, land-use activities, and climate change, over a time span of multiple decades and across a range of different scenarios when quantifying available surface water yields and the potential for reservoir expansion.

Social networks and well-being: a comparison of older people in Mediterranean and non-Mediterranean countries.

PubMed

Litwin, Howard

2010-09-01

This study examined whether the social networks of older persons in Mediterranean and non-Mediterranean countries were appreciably different and whether they functioned in similar ways in relation to well-being outcomes. The sample included family household respondents aged 60 years and older from the first wave of the Survey of Health, Ageing and Retirement in Europe in 5 Mediterranean (n = 3,583) and 7 non-Mediterranean (n = 5,471) countries. Region was regressed separately by gender on variables from 4 network domains: structure and interaction, exchange, engagement and relationship quality, and controlling for background and health characteristics. In addition, 2 well-being outcomes-depressive symptoms and perceived income inadequacy-were regressed on the study variables, including regional social network interaction terms. The results revealed differences across the 2 regional settings in each of the realms of social network, above and beyond the differences that exist in background characteristics and health status. The findings also showed that the social network variables had different effects on the well-being outcomes in the respective settings. The findings underscore that the social network phenomenon is contextually bound. The social networks of older people should be seen within their unique regional milieu and in relation to the values and social norms that prevail in different sets of societies.

Dual-energy-based metal segmentation for metal artifact reduction in dental computed tomography.

PubMed

Hegazy, Mohamed A A; Eldib, Mohamed Elsayed; Hernandez, Daniel; Cho, Myung Hye; Cho, Min Hyoung; Lee, Soo Yeol

2018-02-01

In a dental CT scan, the presence of dental fillings or dental implants generates severe metal artifacts that often compromise readability of the CT images. Many metal artifact reduction (MAR) techniques have been introduced, but dental CT scans still suffer from severe metal artifacts particularly when multiple dental fillings or implants exist around the region of interest. The high attenuation coefficient of teeth often causes erroneous metal segmentation, compromising the MAR performance. We propose a metal segmentation method for a dental CT that is based on dual-energy imaging with a narrow energy gap. Unlike a conventional dual-energy CT, we acquire two projection data sets at two close tube voltages (80 and 90 kV p ), and then, we compute the difference image between the two projection images with an optimized weighting factor so as to maximize the contrast of the metal regions. We reconstruct CT images from the weighted difference image to identify the metal region with global thresholding. We forward project the identified metal region to designate metal trace on the projection image. We substitute the pixel values on the metal trace with the ones computed by the region filling method. The region filling in the metal trace removes high-intensity data made by the metallic objects from the projection image. We reconstruct final CT images from the region-filled projection image with the fusion-based approach. We have done imaging experiments on a dental phantom and a human skull phantom using a lab-built micro-CT and a commercial dental CT system. We have corrected the projection images of a dental phantom and a human skull phantom using the single-energy and dual-energy-based metal segmentation methods. The single-energy-based method often failed in correcting the metal artifacts on the slices on which tooth enamel exists. The dual-energy-based method showed better MAR performances in all cases regardless of the presence of tooth enamel on the slice of interest. We have compared the MAR performances between both methods in terms of the relative error (REL), the sum of squared difference (SSD) and the normalized absolute difference (NAD). For the dental phantom images corrected by the single-energy-based method, the metric values were 95.3%, 94.5%, and 90.6%, respectively, while they were 90.1%, 90.05%, and 86.4%, respectively, for the images corrected by the dual-energy-based method. For the human skull phantom images, the metric values were improved from 95.6%, 91.5%, and 89.6%, respectively, to 88.2%, 82.5%, and 81.3%, respectively. The proposed dual-energy-based method has shown better performance in metal segmentation leading to better MAR performance in dental imaging. We expect the proposed metal segmentation method can be used to improve the MAR performance of existing MAR techniques that have metal segmentation steps in their correction procedures. © 2017 American Association of Physicists in Medicine.

Regional Variation in Geniohyoid Muscle Strain During Suckling in the Infant Pig

PubMed Central

HOLMAN, SHAINA DEVI; KONOW, NICOLAI; LUKASIK, STACEY L.; GERMAN, REBECCA Z.

2014-01-01

The geniohyoid muscle (GH) is a critical suprahyoid muscle in most mammalian oropharyngeal motor activities. We used sonomicrometry to evaluate regional strain (i.e., changes in length) in the muscle origin, belly, and insertion during suckling in infant pigs, and compared the results to existing information on strain heterogeneity in the hyoid musculature. We tested the hypothesis that during rhythmic activity, the GH shows regional variation in muscle strain. We used sonomicrometry transducer pairs to divide the muscle into three regions from anterior to posterior. The results showed differences in strain among the regions within a feeding cycle; however, no region consistently shortened or lengthened over the course of a cycle. Moreover, regional strain patterns were not correlated with timing of the suck cycles, neither (1) relative to a swallow cycle (before or after) nor (2) to the time in feeding sequence (early or late). We also found a tight relationship between muscle activity and muscle strain, however, the relative timing of muscle activity and muscle strain was different in some muscle regions and between individuals. A dissection of the C1 innervations of the geniohyoid showed that there are between one and three branches entering the muscle, possibly explaining the variation seen in regional activity and strain. In combination, our findings suggest that regional heterogeneity in muscle strain during patterned suckling behavior functions to stabilize the hyoid bone, whereas the predictable regional strain differences in reflexive behaviors may be necessary for faster and higher amplitude movements of the hyoid bone. PMID:22549885

Ocean Data Interoperability Platform (ODIP): using regional data systems for global ocean research

NASA Astrophysics Data System (ADS)

Schaap, D.; Thijsse, P.; Glaves, H.

2017-12-01

Ocean acidification, loss of coral reefs, sustainable exploitation of the marine environment are just a few of the challenges researchers around the world are currently attempting to understand and address. However, studies of these ecosystem level challenges are impossible unless researchers can discover and re-use the large volumes of interoperable multidisciplinary data that are currently only accessible through regional and global data systems that serve discreet, and often discipline specific, user communities. The plethora of marine data systems currently in existence are also using different standards, technologies and best practices making re-use of the data problematic for those engaged in interdisciplinary marine research. The Ocean Data Interoperability Platform (ODIP) is responding to this growing demand for discoverable, accessible and reusable data by establishing the foundations for a common global framework for marine data management. But creation of such an infrastructure is a major undertaking, and one that needs to be achieved in part by establishing different levels of interoperability across existing regional and global marine e-infrastructures. Workshops organised by ODIP II facilitate dialogue between selected regional and global marine data systems in an effort to identify potential solutions that integrate these marine e-infrastructures. The outcomes of these discussions have formed the basis for a number of prototype development tasks that aim to demonstrate effective sharing of data across multiple data systems, and allow users to access data from more than one system through a single access point. The ODIP II project is currently developing four prototype solutions that are establishing interoperability between selected regional marine data management infrastructures in Europe, the USA, Canada and Australia, and with the global POGO, IODE Ocean Data Portal (ODP) and GEOSS systems. The potential impact of implementing these solutions for the individual marine data infrastructures is also being evaluated to determine both the technical and financial implications of their integration within existing systems. These impact assessments form part of the strategy to encourage wider adoption of the ODIP solutions and approach beyond the current scope of the project.

Microglial brain region-dependent diversity and selective regional sensitivities to ageing

PubMed Central

Grabert, Kathleen; Michoel, Tom; Karavolos, Michail H; Clohisey, Sara; Baillie, J Kenneth; Stevens, Mark P; Freeman, Tom C; Summers, Kim M; McColl, Barry W

2015-01-01

Microglia play critical roles in neural development, homeostasis and neuroinflammation and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration often occurs in disease-specific spatially-restricted patterns, the origins of which are unknown. We performed the first genome-wide analysis of microglia from discrete brain regions across the adult lifespan of the mouse and reveal that microglia have distinct region-dependent transcriptional identities and age in a regionally variable manner. In the young adult brain, differences in bioenergetic and immunoregulatory pathways were the major sources of heterogeneity and suggested that cerebellar and hippocampal microglia exist in a more immune vigilant state. Immune function correlated with regional transcriptional patterns. Augmentation of the distinct cerebellar immunophenotype and a contrasting loss in distinction of the hippocampal phenotype among forebrain regions were key features during ageing. Microglial diversity may enable regionally localised homeostatic functions but could also underlie region-specific sensitivities to microglial dysregulation and involvement in age-related neurodegeneration. PMID:26780511

Comparison of emissions inventories of anthropogenic air pollutants and greenhouse gases in China

NASA Astrophysics Data System (ADS)

Saikawa, Eri; Kim, Hankyul; Zhong, Min; Avramov, Alexander; Zhao, Yu; Janssens-Maenhout, Greet; Kurokawa, Jun-ichi; Klimont, Zbigniew; Wagner, Fabian; Naik, Vaishali; Horowitz, Larry W.; Zhang, Qiang

2017-05-01

Anthropogenic air pollutant emissions have been increasing rapidly in China, leading to worsening air quality. Modelers use emissions inventories to represent the temporal and spatial distribution of these emissions needed to estimate their impacts on regional and global air quality. However, large uncertainties exist in emissions estimates. Thus, assessing differences in these inventories is essential for the better understanding of air pollution over China. We compare five different emissions inventories estimating emissions of carbon dioxide (CO2), carbon monoxide (CO), nitrogen oxides (NOx), sulfur dioxide (SO2), and particulate matter with an aerodynamic diameter of 10 µm or less (PM10) from China. The emissions inventories analyzed in this paper include the Regional Emission inventory in ASia v2.1 (REAS), the Multi-resolution Emission Inventory for China (MEIC), the Emission Database for Global Atmospheric Research v4.2 (EDGAR), the inventory by Yu Zhao (ZHAO), and the Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS). We focus on the period between 2000 and 2008, during which Chinese economic activities more than doubled. In addition to national totals, we also analyzed emissions from four source sectors (industry, transport, power, and residential) and within seven regions in China (East, North, Northeast, Central, Southwest, Northwest, and South) and found that large disagreements exist among the five inventories at disaggregated levels. These disagreements lead to differences of 67 µg m-3, 15 ppbv, and 470 ppbv for monthly mean PM10, O3, and CO, respectively, in modeled regional concentrations in China. We also find that all the inventory emissions estimates create a volatile organic compound (VOC)-limited environment and MEIC emissions lead to much lower O3 mixing ratio in East and Central China compared to the simulations using REAS and EDGAR estimates, due to their low VOC emissions. Our results illustrate that a better understanding of Chinese emissions at more disaggregated levels is essential for finding effective mitigation measures for reducing national and regional air pollution in China.

Ecoregions and ecodistricts: Ecological regionalizations for the Netherlands' environmental policy

NASA Astrophysics Data System (ADS)

Klijn, Frans; de Waal, Rein W.; Oude Voshaar, Jan H.

1995-11-01

For communicating data on the state of the environment to policy makers, various integrative frameworks are used, including regional integration. For this kind of integration we have developed two related ecological regionalizations, ecoregions and ecodistricts, which are two levels in a series of classifications for hierarchically nested ecosystems at different spatial scale levels. We explain the compilation of the maps from existing geographical data, demonstrating the relatively holistic, a priori integrated approach. The resulting maps are submitted to discriminant analysis to test the consistancy of the use of mapping characteristics, using data on individual abiotic ecosystem components from a national database on a 1-km2 grid. This reveals that the spatial patterns of soil, groundwater, and geomorphology correspond with the ecoregion and ecodistrict maps. Differences between the original maps and maps formed by automatically reclassifying 1-km2 cells with these discriminant components are found to be few. These differences are discussed against the background of the principal dilemma between deductive, a priori integrated, and inductive, a posteriori, classification.

Towards decision support for waiting lists: an operations management view.

PubMed

Vissers, J M; Van Der Bij, J D; Kusters, R J

2001-06-01

This paper considers the phenomenon of waiting lists in a healthcare setting, which is characterised by limitations on the national expenditure, to explore the potentials of an operations management perspective. A reference framework for waiting list management is described, distinguishing different levels of planning in healthcare--national, regional, hospital and process--that each contributes to the existence of waiting lists through managerial decision making. In addition, different underlying mechanisms in demand and supply are distinguished, which together explain the development of waiting lists. It is our contention that within this framework a series of situation specific models should be designed to support communication and decision making. This is illustrated by the modelling of the demand for cataract treatment in a regional setting in the south-eastern part of the Netherlands. An input-output model was developed to support decisions regarding waiting lists. The model projects the demand for treatment at a regional level and makes it possible to evaluate waiting list impacts for different scenarios to meet this demand.

The role of the society of Latin American specialists on remote sensing (SELPER) in the analysis and actions related to the main advances and needs of spatial remote sensing for Latin America

NASA Astrophysics Data System (ADS)

Araya, Mauricio F.

The existence of SELPER (Sociedad de Especialistas Latinoamericanos en Percepción Remota / Society of Latinamerican Specialists on Remote Sensing) has filled a great gap among latinamerican countries. SELPER was formed in 1980 and several important activities, having international support, have been performed and are planned in the near future. SELPER consolidation will help develop several important regional cooperation programs and the next years look very promisory in this sense. Different steps are planned but the most important is related with the formation of such a Latin American Council on Remote Sensing, having official support from different countries of the region; SELPER can help this important objective. Main advances and needs are summarized in this paper and it is possible to conclude that SELPER will be important for regional and inter-regional scientific and technical cooperation on remote sensing.

a Robust Descriptor Based on Spatial and Frequency Structural Information for Visible and Thermal Infrared Image Matching

NASA Astrophysics Data System (ADS)

Fu, Z.; Qin, Q.; Wu, C.; Chang, Y.; Luo, B.

2017-09-01

Due to the differences of imaging principles, image matching between visible and thermal infrared images still exist new challenges and difficulties. Inspired by the complementary spatial and frequency information of geometric structural features, a robust descriptor is proposed for visible and thermal infrared images matching. We first divide two different spatial regions to the region around point of interest, using the histogram of oriented magnitudes, which corresponds to the 2-D structural shape information to describe the larger region and the edge oriented histogram to describe the spatial distribution for the smaller region. Then the two vectors are normalized and combined to a higher feature vector. Finally, our proposed descriptor is obtained by applying principal component analysis (PCA) to reduce the dimension of the combined high feature vector to make our descriptor more robust. Experimental results showed that our proposed method was provided with significant improvements in correct matching numbers and obvious advantages by complementing information within spatial and frequency structural information.

The registration of non-cooperative moving targets laser point cloud in different view point

NASA Astrophysics Data System (ADS)

Wang, Shuai; Sun, Huayan; Guo, Huichao

2018-01-01

Non-cooperative moving target multi-view cloud registration is the key technology of 3D reconstruction of laser threedimension imaging. The main problem is that the density changes greatly and noise exists under different acquisition conditions of point cloud. In this paper, firstly, the feature descriptor is used to find the most similar point cloud, and then based on the registration algorithm of region segmentation, the geometric structure of the point is extracted by the geometric similarity between point and point, The point cloud is divided into regions based on spectral clustering, feature descriptors are created for each region, searching to find the most similar regions in the most similar point of view cloud, and then aligning the pair of point clouds by aligning their minimum bounding boxes. Repeat the above steps again until registration of all point clouds is completed. Experiments show that this method is insensitive to the density of point clouds and performs well on the noise of laser three-dimension imaging.

Global climate change and intensification of coastal ocean upwelling.

PubMed

Bakun, A

1990-01-12

A mechanism exists whereby global greenhouse warning could, by intensifying the alongshore wind stress on the ocean surface, lead to acceleration of coastal upwelling. Evidence from several different regions suggests that the major coastal upwelling systems of the world have been growing in upwelling intensity as greenhouse gases have accumulated in the earth's atmosphere. Thus the cool foggy summer conditions that typify the coastlands of northern California and other similar upwelling regions might, under global warming, become even more pronounced. Effects of enhanced upwelling on the marine ecosystem are uncertain but potentially dramatic.

Kepler: NASA's First Mission Capable of Finding Earth-Size Planets

NASA Technical Reports Server (NTRS)

Borucki, William J.

2009-01-01

Kepler, a NASA Discovery mission, is a spaceborne telescope designed to search a nearby region of our galaxy for Earth-size planets orbiting in the habitable zone of stars like our sun. The habitable zone is that region around a start where the temperature permits water to be liquid on the surface of a planet. Liquid water is considered essential forth existence of life. Mission Phases: Six mission phases have been defined to describe the different periods of activity during Kepler's mission. These are: launch; commissioning; early science operations, science operations: and decommissioning

Observation of Isotope Ratios (δ2H, δ18O, 87Sr/86Sr) of Tap Water in Urban Environments

NASA Astrophysics Data System (ADS)

Mancuso, C. J.; Tipple, B. J.; Ehleringer, J. R.

2014-12-01

Urban environments are centers for rapidly growing populations. In order to meet the culinary water needs of these areas, municipal water departments use water from multiple locations and/or sources, often piped differentially to different locations within a municipality. This practice creates isotopically distinct locations within an urban area and therefore provides insight to urban water management practices. In our study we selected urban locations in the Salt Lake Valley, UT (SLV) and San Francisco Bay Area, CA (SFB) where we hypothesized geographically distinct water isotopic ratio differences existed. Within the SLV, municipal waters come from the same mountainous region, but are derived from different geologically distinct watersheds. In contrast, SFB waters are derived from regionally distinct water sources. We hypothesized that the isotope ratios of tap waters would differ based upon known municipal sources. To test this, tap water samples were collected throughout the urban regions in SLV and SFB and analyzed for δ2H, δ18O and 87Sr/86Sr isotope ratios. Seasonal collections were also made to assess if isotope ratios differed throughout the year. Within SLV and SFB, different regions were characterized by distinct paired δ18O and 87Sr/86Sr values. These different realms also agreed with known differences in municipal water supplies within the general geographic region. Waters from different cities within Marin County showed isotopic differences, consistent with water derived from different local reservoirs. Seasonal variation was observed in paired δ18O and 87Sr/86Sr values of tap water for some locations within SLV and SFB, indicating management decisions to shift from one water source to another depending on demand and available resources. Our study revealed that the δ18O and 87Sr/86Sr values of tap waters in an urban region can exhibit significant differences despite close spatial proximity if districts differ in their use of local versus transported waters.

[Analysis on difference of richness of traditional Chinese medicine resources in Chongqing based on grid technology].

PubMed

Zhang, Xiao-Bo; Qu, Xian-You; Li, Meng; Wang, Hui; Jing, Zhi-Xian; Liu, Xiang; Zhang, Zhi-Wei; Guo, Lan-Ping; Huang, Lu-Qi

2017-11-01

After the end of the national and local medicine resources census work, a large number of Chinese medicine resources and distribution of data will be summarized. The species richness between the regions is a valid indicator for objective reflection of inter-regional resources of Chinese medicine. Due to the large difference in the size of the county area, the assessment of the intercropping of the resources of the traditional Chinese medicine by the county as a statistical unit will lead to the deviation of the regional abundance statistics. Based on the rule grid or grid statistical methods, the size of the statistical unit due to different can be reduced, the differences in the richness of traditional Chinese medicine resources are caused. Taking Chongqing as an example, based on the existing survey data, the difference of richness of traditional Chinese medicine resources under different grid scale were compared and analyzed. The results showed that the 30 km grid could be selected and the richness of Chinese medicine resources in Chongqing could reflect the objective situation of intercropping resources richness in traditional Chinese medicine better. Copyright© by the Chinese Pharmaceutical Association.

Change detection for synthetic aperture radar images based on pattern and intensity distinctiveness analysis

NASA Astrophysics Data System (ADS)

Wang, Xiao; Gao, Feng; Dong, Junyu; Qi, Qiang

2018-04-01

Synthetic aperture radar (SAR) image is independent on atmospheric conditions, and it is the ideal image source for change detection. Existing methods directly analysis all the regions in the speckle noise contaminated difference image. The performance of these methods is easily affected by small noisy regions. In this paper, we proposed a novel change detection framework for saliency-guided change detection based on pattern and intensity distinctiveness analysis. The saliency analysis step can remove small noisy regions, and therefore makes the proposed method more robust to the speckle noise. In the proposed method, the log-ratio operator is first utilized to obtain a difference image (DI). Then, the saliency detection method based on pattern and intensity distinctiveness analysis is utilized to obtain the changed region candidates. Finally, principal component analysis and k-means clustering are employed to analysis pixels in the changed region candidates. Thus, the final change map can be obtained by classifying these pixels into changed or unchanged class. The experiment results on two real SAR images datasets have demonstrated the effectiveness of the proposed method.

Scattering of massless scalar waves by magnetically charged black holes in Einstein-Yang-Mills-Higgs theory

NASA Astrophysics Data System (ADS)

Gußmann, Alexander

2017-03-01

The existence of the classical black hole solutions of the Einstein-Yang-Mills-Higgs equations with non-Abelian Yang-Mills-Higgs hair implies that not all classical stationary magnetically charged black holes can be uniquely described by their asymptotic characteristics. In fact, in a certain domain of parameters, there exist different spherically-symmetric, non-rotating and asymptotically-flat classical black hole solutions of the Einstein-Yang-Mills-Higgs equations which have the same ADM mass and the same magnetic charge but significantly different geometries in the near-horizon regions. (These are black hole solutions which are described by a Reissner-Nordström metric on the one hand and the black hole solutions with non-Abelian Yang-Mills-Higgs hair which are described by a metric which is not of Reissner-Nordström form on the other hand). One can experimentally distinguish such black holes with the same asymptotic characteristics but different near-horizon geometries classically by probing the near-horizon regions of the black holes. We argue that one way to probe the near-horizon region of a black hole which allows one to distinguish magnetically charged black holes with the same asymptotic characteristics but different near-horizon geometries is by classical scattering of waves. Using the example of a minimally-coupled massless probe scalar field scattered by magnetically charged black holes which can be obtained as solutions of the Einstein-Yang-Mills-Higgs equations with a Higgs triplet and gauge group SU(2) in the limit of an infinite Higgs self-coupling constant we show how, in this case, the scattering cross sections differ for the magnetically charged black holes with different near-horizon geometries but the same asymptotic characteristics. We find in particular that the characteristic glory peaks in the cross sections are located at different scattering angles.

Spatial and temporal patterns of Amazon rainfall. Consequences for the planning of agricultural occupation and the protection of primary forests.

PubMed

Sombroek, W

2001-11-01

The spatial and temporal pattern of annual rainfall and the strength of the dry season within the Amazon region are poorly known. Existing rainfall maps are based on the data from full-scale, long-term meteorological stations, operated by national organizations linked to the World Meteorological Organisation, such as INMET in Brazil. Stations with 30 or more years of uninterrupted and reliable recordings are very few, considering the size of the region, and most of them are located along the major rivers. It has been suggested that rainfall conditions away from these rivers are substantially different. An analysis has been made of the records of a network of simple pluviometric sites in the Brazilian part of the region as maintained by the National Agency for Electric Energy (ANEEL) since 1970. The latter data sets were used to draw more detailed maps on annual rainfall, and on the strength of the dry season in particular; average number of consecutive months with less than 100 mm, 50 mm, and 10 mm, respectively. Also, some data were obtained on the spatial expression of El Niño events within the region. Subregional differences are large, and it is argued that they are important for the success or failure of agricultural settlements; for the hazard of large-scale fire damage of the still existing primary forest vegetation; for the functioning of this land cover as stock and sink of CO2, and for the likelihood that secondary forests on abandoned agricultural lands will have less biomass. The effects of past El Niño rainfall anomalies on the biodiversity of the natural savannahs within the forest region are discussed.

Regional Differences in Case Mix and Peri-operative Outcome After Elective Abdominal Aortic Aneurysm Repair in the Vascunet Database.

PubMed

Mani, K; Venermo, M; Beiles, B; Menyhei, G; Altreuther, M; Loftus, I; Björck, M

2015-06-01

National differences exist in the outcome of elective abdominal aortic aneurysm (AAA) repair. The role of case mix variation was assessed based on an international vascular registry collaboration. All elective AAA repairs with aneurysm size data in the Vascunet database in the period 2005-09 were included. AAA size and peri-operative outcome (crude and age adjusted mortality) were analysed overall and in risk cohorts, as well as per country. Glasgow Aneurysm Score (GAS) was calculated as risk score, and patients were stratified in three equal sized risk cohorts based on GAS. Predictors of peri-operative mortality were analysed with multiple regression. Missing data were handled with multiple imputation. Patients from Australia, Finland, Hungary, Norway, Sweden and the UK (n = 5,895) were analysed; mean age was 72.7 years and 54% had endovascular repair (EVAR). There were significant variations in GAS (lowest = Finland [75.7], highest = UK [79.4], p for comparison of all regions < .001), proportion of AAA < 5.5 cm (lowest = UK [6.4%], highest = Hungary [29.0%]; p < .001), proportion undergoing EVAR (lowest = Finland [10.1%], highest = Australia [58.9%]; p < .001), crude mortality (lowest = Norway [2.0%], highest = Finland [5.0%]; p = .006), and age adjusted mortality (lowest = Norway [2.5%], highest = Finland [6.0%]; p = .048). Both aneurysm size and peri-operative mortality were highest among patients with a GAS >82. Of those with a GAS >82, 8.4% of men and 20.8% of women had an AAA <5.5 cm. Important regional differences exist in case selection for elective AAA repair, including variations in AAA size and patient risk profile. These differences partly explain the variations in peri-operative mortality. Further audit is warranted to assess the underlying reasons for the regional variation in case-mix. Copyright © 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Investigating Indoor Radon Levels and Influencing Factors in Primary Schools of Zulfi City, Saudi Arabia

NASA Astrophysics Data System (ADS)

Al-Ghamdi, S. S.; Al-Garawi, M. S.; Al-Mosa, Tahani M.; Baig, M. R.

2011-10-01

Measurement of indoor Concentrations were performed in Zulfi city of Saudi Arabia, using CR-39 track etch detectors. This investigation focused on the influence of different parameters, namely different locations, school categories, school building types, and room type as well as on the existence of differences in radon concentration at floor levels. We divided the Zulfi city into five regions, keeping in mind their geographical locations between Tuwaiq Mountains and Al-Thuwayrat sands. The measured average radon concentrations for regions 1-5 respectively are: 87.0±14.2 Bq/m3, 83.4±6.0 Bq/m3, 61.6±6.4 Bq/m3, 63.7±5.4 Bq/m3 and 87.5±6.Bq/m3 and the minimum concentrations are 28.0 Bq/m3, 5.5 Bq/m3, 1.1 Bq/m3, 1.0 Bq/m3 and 24 Bq/m3 respectively. These results are still within normal limits and below the action level of 148 Bqm-3 set by the U.S. Environmental Protection Agency (EPA). A test of significance using Minitab program was applied to investigate if radon levels in regions are significantly different from each other. We tried all combinations, and found the following results. The "within regions" (different location) test yielded, region 2 is not significant versus region "1" (p = 0.783) and versus region "5" (P = 0.646), whereas it is significant versus region "3" ( P = 0.0160) and also versus region "4" (p = 0.018). We investigated government and rented school's building also and none was found significantly different (p = 0.052). Floors of the same building were tested in order to examine the radon concentration as a function of storey level. No significant difference was observed at floor levels (p = 0.009). When girl's schools versus Boys and kindergartens schools were tested they were found significantly different. It is believed that this significant difference is due to geographical nature of the area, since most of the girl's schools were selected from regions 2 and 3, these regions are relatively close to the Tuwaiq mountains whereas other regions are near to the Al-Thuwayrat sands.

Investigating Indoor Radon Levels and Influencing Factors in Primary Schools of Zulfi City, Saudi Arabia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Ghamdi, S. S.; Al-Garawi, M. S.; Al-Mosa, Tahani M.

Measurement of indoor Concentrations were performed in Zulfi city of Saudi Arabia, using CR-39 track etch detectors. This investigation focused on the influence of different parameters, namely different locations, school categories, school building types, and room type as well as on the existence of differences in radon concentration at floor levels. We divided the Zulfi city into five regions, keeping in mind their geographical locations between Tuwaiq Mountains and Al-Thuwayrat sands. The measured average radon concentrations for regions 1-5 respectively are: 87.0{+-}14.2 Bq/m{sup 3}, 83.4{+-}6.0 Bq/m{sup 3}, 61.6{+-}6.4 Bq/m{sup 3}, 63.7{+-}5.4 Bq/m{sup 3} and 87.5{+-}6.Bq/m{sup 3} and the minimum concentrationsmore » are 28.0 Bq/m{sup 3}, 5.5 Bq/m{sup 3}, 1.1 Bq/m{sup 3}, 1.0 Bq/m{sup 3} and 24 Bq/m{sup 3} respectively. These results are still within normal limits and below the action level of 148 Bqm{sup -3} set by the U.S. Environmental Protection Agency (EPA). A test of significance using Minitab program was applied to investigate if radon levels in regions are significantly different from each other. We tried all combinations, and found the following results. The ''within regions''(different location) test yielded, region 2 is not significant versus region ''1''(p = 0.783) and versus region ''5''(P = 0.646), whereas it is significant versus region ''3''(P = 0.0160) and also versus region ''4''(p = 0.018). We investigated government and rented school's building also and none was found significantly different (p = 0.052). Floors of the same building were tested in order to examine the radon concentration as a function of storey level. No significant difference was observed at floor levels (p = 0.009). When girl's schools versus Boys and kindergartens schools were tested they were found significantly different. It is believed that this significant difference is due to geographical nature of the area, since most of the girl's schools were selected from regions 2 and 3, these regions are relatively close to the Tuwaiq mountains whereas other regions are near to the Al-Thuwayrat sands.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ulrike Thoma

The possibility that gluonic excitations of hadronic matter or of the QCD vacuum may exist is perhaps one of the most fascinating topics in hadron spectroscopy. Glueballs are predicted by many models; in particular present-day lattice gauge calculations require their existence. All these models agree that the lightest glueball should have scalar quantum numbers and a mass around 1.6 GeV, which corresponds to the mass region where the scalar qq[bar]-mesons are expected. Therefore mixing effects can complicate the search for the glueball. Experiments indeed show an overpopulation of states, for which many different interpretations exist. This reflects the complexity ofmore » the situation. New data from various experiments on scalar states give hints toward an interpretation of the scalar states. But, still many questions remain.« less

Potential causes of differences between ground and surface air temperature warming across different ecozones in Alberta, Canada

NASA Astrophysics Data System (ADS)

Majorowicz, Jacek A.; Skinner, Walter R.

1997-10-01

Analysis and modelling of temperature anomalies from 25 selected deep wells in Alberta show that the differences between GST (ground surface temperature) warming for the northern Boreal Forest ecozone and the combined Prairie Grassland ecozone and Aspen Parkland transition region to the south occur during the latter half of this century. This corresponds with recent changes in surface albedo resulting from permanent land development in the northern areas and also to increases in natural forest fires in the past 20 years. Differences between GST and SAT (surface air temperature) warming are much higher in the Boreal Forest ecozone than in the Prairie Grassland ecozone and Aspen Parkland transition region. Various hypotheses which could account for the existing differences between the GST and SAT warming in the different ecozones of Alberta, and western Canada in general, are tested. Analysis of existing data on soil temperature, hydrological piezometric surfaces, snowfall and moisture patterns, and land clearing and forest fires, indicate that large areas of Alberta, characterised by anomalous GST warming, have experienced widespread changes to the surface landscape in this century. It is postulated that this has resulted in a lower surface albedo with a subsequent increase in the absorption of solar energy. Heat flow modelling shows that, after climatic SAT warming, permanent clearing of the land is the most effective and likely cause of the observed changes in the GST warming. The greater GST warming in the Boreal Forest ecozone in the latter half of this century is related to landscape change due to land development and increasing forest fire activity. It appears to account for a portion of the observed SAT warming in this region through a positive feedback loop with the overlying air. The anthropogenic effect on regional climatic warming through 20th century land clearing and landscape alteration requires further study. In future, more accurate quantification of these various forcings will be necessary in order to distinguish between, and to detect, the variety of natural and anthropogenic influences and on climate.

Formation of structural steady states in lamellar/sponge phase-separating fluids under shear flow

NASA Astrophysics Data System (ADS)

Panizza, P.; Courbin, L.; Cristobal, G.; Rouch, J.; Narayanan, T.

2003-05-01

We investigate the effect of shear flow on a lamellar-sponge phase-separating fluid when subjected to shear flow. We show the existence of two different steady states (droplets and ribbons structures) whose nature does not depend on the way to reach the two-phase unstable region of the phase diagram (temperature quench or stirring). The transition between ribbons and droplets is shear thickening and its nature strongly depends on what dynamical variable is imposed. If the stress is fixed, flow visualization shows the existence of shear bands at the transition, characteristic of coexistence in the cell between ribbons and droplets. In this shear-banding region, the viscosity oscillates. When the shear rate is fixed, no shear bands are observed. Instead, the transition exhibits a hysteretic behavior leading to a structural bi-stability of the phase-separating fluid under flow.

Cloud cover determination in polar regions from satellite imagery

NASA Technical Reports Server (NTRS)

Barry, R. G.; Maslanik, J. A.; Key, J. R.

1987-01-01

A definition is undertaken of the spectral and spatial characteristics of clouds and surface conditions in the polar regions, and to the creation of calibrated, geometrically correct data sets suitable for quantitative analysis. Ways are explored in which this information can be applied to cloud classifications as new methods or as extensions to existing classification schemes. A methodology is developed that uses automated techniques to merge Advanced Very High Resolution Radiometer (AVHRR) and Scanning Multichannel Microwave Radiometer (SMMR) data, and to apply first-order calibration and zenith angle corrections to the AVHRR imagery. Cloud cover and surface types are manually interpreted, and manual methods are used to define relatively pure training areas to describe the textural and multispectral characteristics of clouds over several surface conditions. The effects of viewing angle and bidirectional reflectance differences are studied for several classes, and the effectiveness of some key components of existing classification schemes is tested.

Empirical estimates to reduce modeling uncertainties of soil organic carbon in permafrost regions: a review of recent progress and remaining challenges

USGS Publications Warehouse

Mishra, U.; Jastrow, J.D.; Matamala, R.; Hugelius, G.; Koven, C.D.; Harden, Jennifer W.; Ping, S.L.; Michaelson, G.J.; Fan, Z.; Miller, R.M.; McGuire, A.D.; Tarnocai, C.; Kuhry, P.; Riley, W.J.; Schaefer, K.; Schuur, E.A.G.; Jorgenson, M.T.; Hinzman, L.D.

2013-01-01

The vast amount of organic carbon (OC) stored in soils of the northern circumpolar permafrost region is a potentially vulnerable component of the global carbon cycle. However, estimates of the quantity, decomposability, and combustibility of OC contained in permafrost-region soils remain highly uncertain, thereby limiting our ability to predict the release of greenhouse gases due to permafrost thawing. Substantial differences exist between empirical and modeling estimates of the quantity and distribution of permafrost-region soil OC, which contribute to large uncertainties in predictions of carbon–climate feedbacks under future warming. Here, we identify research challenges that constrain current assessments of the distribution and potential decomposability of soil OC stocks in the northern permafrost region and suggest priorities for future empirical and modeling studies to address these challenges.

Central and Divided Visual Field Presentation of Emotional Images to Measure Hemispheric Differences in Motivated Attention.

PubMed

O'Hare, Aminda J; Atchley, Ruth Ann; Young, Keith M

2017-11-16

Two dominant theories on lateralized processing of emotional information exist in the literature. One theory posits that unpleasant emotions are processed by right frontal regions, while pleasant emotions are processed by left frontal regions. The other theory posits that the right hemisphere is more specialized for the processing of emotional information overall, particularly in posterior regions. Assessing the different roles of the cerebral hemispheres in processing emotional information can be difficult without the use of neuroimaging methodologies, which are not accessible or affordable to all scientists. Divided visual field presentation of stimuli can allow for the investigation of lateralized processing of information without the use of neuroimaging technology. This study compared central versus divided visual field presentations of emotional images to assess differences in motivated attention between the two hemispheres. The late positive potential (LPP) was recorded using electroencephalography (EEG) and event-related potentials (ERPs) methodologies to assess motivated attention. Future work will pair this paradigm with a more active behavioral task to explore the behavioral impacts on the attentional differences found.

Stable Isotopes Reveal Long-Term Fidelity to Foraging Grounds in the Galapagos Sea Lion (Zalophus wollebaeki)

PubMed Central

Drago, Massimiliano; Franco-Trecu, Valentina; Cardona, Luis; Inchausti, Pablo; Tapia, Washington; Páez-Rosas, Diego

2016-01-01

Most otariids have colony-specific foraging areas during the breeding season, when they behave as central place foragers. However, they may disperse over broad areas after the breeding season and individuals from different colonies may share foraging grounds at that time. Here, stable isotope ratios in the skull bone of adult Galapagos sea lions (Zalophus wollebaeki) were used to assess the long-term fidelity of both sexes to foraging grounds across the different regions of the Galapagos archipelago. Results indicated that the stable isotope ratios (δ13C and δ15N) of sea lion bone significantly differed among regions of the archipelago, without any significant difference between sexes and with a non significant interaction between sex and region. Moreover, standard ellipses, estimated by Bayesian inference and used as a measure of the isotopic resource use area at the population level, overlapped widely for the sea lions from the southern and central regions, whereas the overlap of the ellipses for sea lions from the central and western regions was small and non-existing for those from the western and southern regions. These results suggest that males and females from the same region within the archipelago use similar foraging grounds and have similar diets. Furthermore, they indicate that the exchange of adults between regions is limited, thus revealing a certain degree of foraging philopatry at a regional scale within the archipelago. The constraints imposed on males by an expanded reproductive season (~ 6 months), resulting from the weak reproductive synchrony among females, and those imposed on females by a very long lactation period (at least one year but up to three years), may explain the limited mobility of adult Galapagos sea lions of both sexes across the archipelago. PMID:26808381

Sexual Orientation, Objective Height, and Self-Reported Height.

PubMed

Skorska, Malvina N; Bogaert, Anthony F

2017-01-01

Studies that have used mostly self-reported height have found that androphilic men and women are shorter than gynephilic men and women, respectively. This study examined whether an objective height difference exists or whether a psychosocial account (e.g., distortion of self-reports) may explain these putative height differences. A total of 863 participants, recruited at a Canadian university, the surrounding region, and through lesbian, gay, bisexual, and transgender (LGBT) events across Canada, self-reported their height and had their height measured. Androphilic men were shorter, on average, than gynephilic men. There was no objective height difference between gynephilic, ambiphilic, and androphilic women. Self-reported height, statistically controlling for objective height, was not related to sexual orientation. These findings are the first to show an objective height difference between androphilic and gynephilic men. Also, the findings suggest that previous studies using self-reported height found part of a true objective height difference between androphilic and gynephilic men. These findings have implications for existing biological theories of men's sexual orientation development.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krishnan, Venkat; Cole, Wesley

Power sector capacity expansion models (CEMs) have a broad range of spatial resolutions. This paper uses the Regional Energy Deployment System (ReEDS) model, a long-term national scale electric sector CEM, to evaluate the value of high spatial resolution for CEMs. ReEDS models the United States with 134 load balancing areas (BAs) and captures the variability in existing generation parameters, future technology costs, performance, and resource availability using very high spatial resolution data, especially for wind and solar modeled at 356 resource regions. In this paper we perform planning studies at three different spatial resolutions--native resolution (134 BAs), state-level, and NERCmore » region level--and evaluate how results change under different levels of spatial aggregation in terms of renewable capacity deployment and location, associated transmission builds, and system costs. The results are used to ascertain the value of high geographically resolved models in terms of their impact on relative competitiveness among renewable energy resources.« less

Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions.

PubMed

Ono, Chiho; Kikkawa, Hironori; Suzuki, Akiyuki; Suzuki, Misaki; Yamamoto, Yuichi; Ichikawa, Katsuomi; Fukae, Masato; Ieiri, Ichiro

2013-11-01

Drug transporters, together with drug metabolic enzymes, are major determinants of drug disposition and are known to alter the response to many commonly used drugs. Substantial frequency differences for known variants exist across geographic regions for certain drug transporters. To deliver efficacious medicine with the right dose for each patient, it is important to understand the contribution of genetic variants for drug transporters. Recently, mutual pharmacokinetic data usage among Asian regions, which are thought to be relatively similar in their own genetic background, is expected to accelerate new drug applications and reduce developmental costs. Polymorphisms of drug transporters could be key factors to be considered in implementing multiethnic global clinical trials. This review addresses the current knowledge on genetic variations of major drug transporters affecting drug disposition, efficacy and toxicity, focusing on the east Asian populations, and provides insights into future directions for precision medicine and drug development in east Asia.

On the Possibility of the Existence of Volatile Compounds in the Region of the Scott Crater on the Moon

NASA Astrophysics Data System (ADS)

Pugacheva, S. G.; Feoktistova, E. A.; Shevchenko, V. V.

2018-05-01

In this paper, we analyze the illumination conditions, the thermal regime, and the possibility of deposits of volatile compounds existing in the vicinity region (NSR S5 region) near the southern pole of the Moon. It has been found that there are no permanently shadowed zones near the Scott crater and the NSR S5 region, though the temperature conditions allow the of compounds such as CH3OH, SO2, NH3, CO2, H2S, C2H4, and water to remain stable relative to evaporation for a long time (≥1 Gyr). It has been also shown that compounds like CO and CH4 cannot stably exist in these regions.

Random Behaviour or Rational Choice? Family Planning, Teenage Pregnancy and Sexually Transmitted Infections

ERIC Educational Resources Information Center

Paton, David

2006-01-01

Rational choice models of teenage sexual behaviour lead to radically different predictions than do models that assume such behaviour is random. Existing empirical evidence has not been able to distinguish conclusively between these competing models. I use regional data from England between 1998 and 2001 to examine the impact of recent increases in…

Mycelial growth, pathogenicity, aggressiveness and apothecial development of Sclerotinia sclerotiorum isolates from Brazil and the United States in contrasting temperature regimes

USDA-ARS?s Scientific Manuscript database

Fungi can adapt to environmental conditions and produce different physiological responses. The aim of this study was to verify the existence of Sclerotinia sclerotiorum temperature ecotypes in isolates from Brazil and the USA. Ten S. sclerotiorum isolates from tropical and subtropical regions of Bra...

Discovery of cryptic Armillaria solidipes genotypes within the Colorado Plateau

Treesearch

J. W. Hanna; N. B. Klopfenstein; M. -S. Kim; S. M. Ashiglar; A. L. Ross-Davis; G. I. McDonald

2012-01-01

Armillaria solidipes (= A. ostoyae) is a root-disease pathogen that causes severe losses in growth and productivity of forest trees throughout the Northern Hemisphere. This species is genetically diverse with variable disease activities across different regions of the world. In North America, A. solidipes in the Colorado Plateau exists in drier habitats and causes more...

Algal-bacterial co-variation in streams: a cross-stream comparison

Treesearch

Xueqing Gao; Ola A. Olapade; Mark W. Kershner; Laura G. Leff

2004-01-01

Algal-bacterial co-variation has been frequently observed in lentic and marine environments, but the existence of such relationships in lotic ecosystems is not well established. To examine possible co-variation, bacterial number and chlorophyll-a concentration in water and sediments of nine streams from different regions in the USA were examined. In the water, a strong...

On using TRMM data and rainfall forecasts from meteorological models in data-scarce transboundary catchments - an example of Bangladesh

NASA Astrophysics Data System (ADS)

Bhattacharya, Biswa; Tohidul Islam, Md.

2014-05-01

This research focuses on the flood risk of the Haor region in the north-eastern part of Bangladesh. The prediction of the hydrological variables at different spatial and temporal scales in the Haor region is dependent on the influence of several upstream rivers in the Meghalaya catchment in India. Limitation in hydro-meteorological data collection and data sharing issues between the two countries dominate the feasibility of hydrological studies, particularly for near-realtime predictions. One of the possible solutions seems to be in making use of the variety of satellite based and meteorological model products for rainfall. The abundance of a variety of rainfall products provides a good basis of hydrological modelling of a part of the Ganges and Brahmaputra basin. In this research the TRMM data and rainfall forecasts from ECMWF have been compared with the scarce rain gauge data from the upstream Meghalaya catchment. Subsequently, the TRMM data and rainfall forecasts from ECMWF have been used as the meteorological input to a rainfall-runoff model of the Meghalaya catchment. The rainfall-runoff model of Meghalaya has been developed using the DEM data from SRTM. The generated runoff at the outlet of Meghalaya has been used as the upstream boundary condition in the existing rainfall-runoff model of the Haor region. The simulation results have been compared with the existing results based on simulations without any information of the rainfall-runoff in the upstream Meghalaya catchment. The comparison showed that the forecasting lead time has been substantially increased. As per the existing results the forecasting lead time at a number of locations in the catchment was about 6 to 8 hours. With the new results the forecasting lead time has gone up, with different levels of accuracy, to about 24 hours. This additional lead time will be highly beneficial in managing flood risk of the Haor region of Bangladesh. The research shows that satellite based rainfall products and rainfall forecasts from meteorological models can be very useful in flood risk management, particularly for data scarce regions and/or transboundary regions with data sharing issues. Keywords: flood risk management, TRMM, ECMWF, flood forecasting, Haor, Bangladesh. Abbreviations: TRMM: Tropical Rainfall Measuring Mission ECMWF: European Centre for Medium-Range Weather Forecasts DEM: Digital Elevation Model SRTM: Shuttle Radar Topography Mission

Microbial terroir for wine grapes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilbert, J. A.; van der Lelie, D.; Zarraonaindia, I.

2013-12-05

The viticulture industry has been selectively growing vine cultivars with different traits (grape size, shape, color, flavor, yield of fruit, and so forth) for millennia, and small variations in soil composition, water management, climate, and the aspect of vineyards have long been associated with shifts in these traits. As such, many different clonal varieties of vines exist, even within given grape varieties, such as merlot, pinot noir, and chardonnay. The commensal microbial flora that coexists with the plant may be one of the key factors that influence these traits. To date, the role of microbes has been largely ignored, outsidemore » of microbial pathogens, mainly because the technologies did not exist to allow us to look in any real depth or breadth at the community structure of the multitudes of bacterial and fungal species associated with each plant. In PNAS, Bokulich et al. (1) used next-generation sequencing of 16S rRNA and internal transcribed spacer ribosomal sequence to determine the relative abundances of bacteria and fungi, respectively, from grape must (freshly pressed grape juice, containing the skins and seeds) from plants in eight vineyards representing four of the major wine growing regions in California. The authors show that the microbiomes (bacterial and fungal taxonomic structure) associated with this early fermentation stage show defined biogeography, illustrating that different wine-growing regions maintain different microbial communities, with some influences from the grape variety and the year of production.« less

ERP profiles for face and word recognition are based on their status in semantic memory not their stimulus category.

PubMed

Nie, Aiqing; Griffin, Michael; Keinath, Alexander; Walsh, Matthew; Dittmann, Andrea; Reder, Lynne

2014-04-04

Previous research has suggested that faces and words are processed and remembered differently as reflected by different ERP patterns for the two types of stimuli. Specifically, face stimuli produced greater late positive deflections for old items in anterior compared to posterior regions, while word stimuli produced greater late positive deflections in posterior compared to anterior regions. Given that words have existing representations in subjects׳ long-term memories (LTM) and that face stimuli used in prior experiments were of unknown individuals, we conducted an ERP study that crossed face and letter stimuli with the presence or absence of a prior (stable or existing) memory representation. During encoding, subjects judged whether stimuli were known (famous face or real word) or not known (unknown person or pseudo-word). A surprise recognition memory test required subjects to distinguish between stimuli that appeared during the encoding phase and stimuli that did not. ERP results were consistent with previous research when comparing unknown faces and words; however, the late ERP pattern for famous faces was more similar to that for words than for unknown faces. This suggests that the critical ERP difference is mediated by whether there is a prior representation in LTM, and not whether the stimulus involves letters or faces. Published by Elsevier B.V.

Application of method of volume averaging coupled with time resolved PIV to determine transport characteristics of turbulent flows in porous bed

NASA Astrophysics Data System (ADS)

Patil, Vishal; Liburdy, James

2012-11-01

Turbulent porous media flows are encountered in catalytic bed reactors and heat exchangers. Dispersion and mixing properties of these flows play an essential role in efficiency and performance. In an effort to understand these flows, pore scale time resolved PIV measurements in a refractive index matched porous bed were made. Pore Reynolds numbers, based on hydraulic diameter and pore average velocity, were varied from 400-4000. Jet-like flows and recirculation regions associated with large scale structures were found to exist. Coherent vortical structures which convect at approximately 0.8 times the pore average velocity were identified. These different flow regions exhibited different turbulent characteristics and hence contributed unequally to global transport properties of the bed. The heterogeneity present within a pore and also from pore to pore can be accounted for in estimating transport properties using the method of volume averaging. Eddy viscosity maps and mean velocity field maps, both obtained from PIV measurements, along with the method of volume averaging were used to predict the dispersion tensor versus Reynolds number. Asymptotic values of dispersion compare well to existing correlations. The role of molecular diffusion was explored by varying the Schmidt number and molecular diffusion was found to play an important role in tracer transport, especially in recirculation regions. Funding by NSF grant 0933857, Particulate and Multiphase Processing.

Profiling of primary metabolites and flavonols in leaves of two table grape varieties collected from semiarid and temperate regions.

PubMed

Harb, Jamil; Alseekh, Saleh; Tohge, Takayuki; Fernie, Alisdair R

2015-09-01

Cultivation of grapes in West Bank - Palestine is very old and a large number of grape varieties exist as a result of continuous domestication over thousands of years. This rich biodiversity has highly influenced the consumer behavior of local people, who consume both grape berries and leaves. However, studies that address the contents of health-promoting metabolites in leaves are scarce. Accordingly the aim of this study is to assess metabolite levels in leaves of two grape varieties that were collected from semiarid and temperate regions. Metabolic profiling was conducted using GC-MS and LC-MS. The obtained results show that abiotic stresses in the semiarid region led to clear changes in primary metabolites, in particular in amino acids, which exist at very high levels. By contrast, qualitative and genotype-dependent differences in secondary metabolites were observed, whereas abiotic stresses appear to have negligible effect on the content of these metabolites. The qualitative difference in the flavonol profiles between the two genotypes is most probably related to differential expression of specific genes, in particular flavonol 3-O-rhamnosyltransferase, flavonol-3-O-glycoside pentosyltransferases and flavonol-3-O-d-glucosidel-rhamnosyltransferase by 'Beituni' grape leaves, which led to much higher levels of flavonols with rutinoside, pentoside, and rhamnoside moieties with this genotype. Copyright © 2015 Elsevier Ltd. All rights reserved.

A theoretical study on the geometry and spectroscopic properties of ground-state and local minima isomers of (CuS)n=2-6 clusters

NASA Astrophysics Data System (ADS)

Luque-Ceballos, Jonathan C.; Posada-Borbón, Alvaro; Herrera-Urbina, Ronaldo; Aceves, R.; Juárez-Sánchez, J. Octavio; Posada-Amarillas, Alvaro

2018-03-01

Spectroscopic properties of gas-phase copper sulfide clusters (CuS)n (n = 2-6) are calculated using Density Functional Theory (DFT) and time-dependent (TD) DFT approaches. The energy landscape of the potential energy surface is explored through a basin-hopping DFT methodology. Ground-state and low-lying isomer structures are obtained. The global search was performed at the B3PW91/SDD level of theory. Normal modes are calculated to validate the existence of optimal cluster structures. Energetic properties are obtained for the ground-state and isomer clusters and their relative energies are evaluated for probing isomerization. This is a few tenths of an eV, except for (CuS)2 cluster, which presents energy differences of ∼1 eV. Notable differences in the infrared spectra exist between the ground-state and first isomer structures, even for the (CuS)5 cluster, which has in both configurations a core copper pyramid. TDDFT provides the simulated absorption spectrum, presenting a theoretical description of optical absorption bands in terms of electronic excitations in the UV and visible regions. Results exhibit a significant dependence of the calculated UV/vis spectra on clusters size and shape regarding the ground state structures. Optical absorption is strong in the UV region, and weak or forbidden in the visible region of the spectrum.

Krill population dynamics in the Scotia Sea: variability in growth and mortality within a single population

NASA Astrophysics Data System (ADS)

Reid, K.; Murphy, E. J.; Loeb, V.; Hewitt, R. P.

2002-07-01

Understanding the demographics of Antarctic krill over large scales may be complicated by regional differences in the processes that govern population structure. The influence of regional differences in growth and mortality on population size structure was examined using data on the length-frequency distribution of krill in the Scotia Sea using samples from the South Shetland Islands and South Georgia collected annually from 1991 to 2000. A correction function, which took account of the higher growth rate at South Georgia, produced a consistent similarity in the position of the modal size classes that was not present in the raw data. Optimising the mortality rate, to minimise the differences in the growth corrected length-frequency distribution, suggested a higher mortality rate at South Georgia that the South Shetlands. The intra-specific variations in growth and mortality rates are consistent with published values and with other Euphausiids species. Having accounted for the demographic plasticity, it is apparent that strong recruitment of the smallest size class of krill is represented in both populations simultaneously. It appears that first-year krill are advected into different regions of the Scotia Sea where the resultant population size structure is determined by regional differences in growth and mortality. The majority of the commercial harvest of krill in the Antarctic occurs in a relatively small number of regional fisheries within the Scotia Sea and is managed using population models based on a single set of demographic parameters. Where substantial differences in these parameters exist between fishing areas, the calculation of catch limits should take these differences into account.

Local Workforce Development Boards: Alignment with Operational Indicators and Behavioral Characteristics

ERIC Educational Resources Information Center

Johnson, Sharon Humphreys

2017-01-01

The ability of a region to remain competitively viable is dependent upon attracting new business and retaining existing businesses (Good & Strong, 2015). In many instances, regional growth depends on the workforce and the region's ability to develop a talent pipeline of existing or accessible workers (Blakely & Leigh, 2010). The passage of…

Deprivation and self-reported health: are there 'Scottish effects' in England and Wales?

PubMed

Whynes, David K

2009-03-01

Although the association between poor health and deprivation is well-founded, a 'Scottish effect' has been observed, whereby the level of health appears even poorer than Scotland's higher level of deprivation should warrant. We consider whether 'Scottish effects' also occur within the regions of England and Wales. Using ward-level data from the national census, we regress healthy life expectancies relative to total life expectancies on Carstairs deprivation scores, households' average disposable incomes, geo-spatial characteristics and regional dummy variables. Higher incomes and lower Carstairs scores are each associated with longer proportions of lives expected to be spent in good health or without long-standing illness. Relative to the London region, the coefficients on the regional dummies are uniformly negative and mostly significant. There exist differences in relative health expectancies between the regions of England and Wales, which are not fully explained by the differences in socio-economic circumstances. Conventional deprivation measures tend to understate the poorer health performances of the more deprived regions (Wales and the north of England), and the understatement increases with deprivation. The exception to the rule is London, where health expectancies are superior to those which deprivation leads us to expect.

Water-quality data-collection activities in Colorado and Ohio; Phase III, evaluation of existing data for use in assessing regional water-quality conditions and trends

USGS Publications Warehouse

Norris, J. Michael; Hren, Janet; Myers, Donna N.; Chaney, Thomas H.; Childress, Carolyn J. Oblinger

1990-01-01

During the past several years, a growing number of questions have been raised by members of Congress and others about the status of current waterquality conditions in the Nation, trends in water quality, and the major factors that affect water-quality conditions and trends. One area of particular interest and concern has been the suitability of existing water-quality data for addressing these types of questions at regional and national scales. In response to these questions and concerns, the U.S. Geological Survey began a pilot study in Colorado and Ohio to (1) determine the characteristics of current water-quality data-collection activities of Federal, State, regional, and local agencies and universities; and (2) determine how well the data from these activities, collected for various purposes and using different procedures, can be used to improve our ability to address the aforementioned questions.Colorado and Ohio were chosen for the pilot study because they represent regions with different types of water-quality issues and programs. The results of the study are specific to the two States and are not intended to be extrapolated to other States.The study was divided into three phases whose objectives were:Phase I Identify and inventory 1984 water-quality data-collection programs, including costs, in Colorado and Ohio, and identify those programs that meet a set of broad criteria for producing data that potentially are appropriate for water-quality assessments of regional and national scope. Phase II Evaluate the quality assurance of field and laboratory procedures used to produce the data from programs that met the broad criteria of Phase I. Phase III Compile the qualifying data from Phase II and evaluate the extent to which the resulting data base can be used to address selected water-quality questions for the two States.This report presents the results of Phase III, focusing on (1) the number of measurements made at each data-collection site for selected constituents, (2) the areal distribution of those sites that have sufficient data for selected types of analyses, and (3) the availability of key ancillary information such as streamflow to address broad-scope questions such as:What are existing water-quality conditions?Has the water quality changed? andHow do existing water-quality conditions and changes in these conditions relate to natural factors and human-induced activities?

Goal-Directed Visual Processing Differentially Impacts Human Ventral and Dorsal Visual Representations

PubMed Central

2017-01-01

Recent studies have challenged the ventral/“what” and dorsal/“where” two-visual-processing-pathway view by showing the existence of “what” and “where” information in both pathways. Is the two-pathway distinction still valid? Here, we examined how goal-directed visual information processing may differentially impact visual representations in these two pathways. Using fMRI and multivariate pattern analysis, in three experiments on human participants (57% females), by manipulating whether color or shape was task-relevant and how they were conjoined, we examined shape-based object category decoding in occipitotemporal and parietal regions. We found that object category representations in all the regions examined were influenced by whether or not object shape was task-relevant. This task effect, however, tended to decrease as task-relevant and irrelevant features were more integrated, reflecting the well-known object-based feature encoding. Interestingly, task relevance played a relatively minor role in driving the representational structures of early visual and ventral object regions. They were driven predominantly by variations in object shapes. In contrast, the effect of task was much greater in dorsal than ventral regions, with object category and task relevance both contributing significantly to the representational structures of the dorsal regions. These results showed that, whereas visual representations in the ventral pathway are more invariant and reflect “what an object is,” those in the dorsal pathway are more adaptive and reflect “what we do with it.” Thus, despite the existence of “what” and “where” information in both visual processing pathways, the two pathways may still differ fundamentally in their roles in visual information representation. SIGNIFICANCE STATEMENT Visual information is thought to be processed in two distinctive pathways: the ventral pathway that processes “what” an object is and the dorsal pathway that processes “where” it is located. This view has been challenged by recent studies revealing the existence of “what” and “where” information in both pathways. Here, we found that goal-directed visual information processing differentially modulates shape-based object category representations in the two pathways. Whereas ventral representations are more invariant to the demand of the task, reflecting what an object is, dorsal representations are more adaptive, reflecting what we do with the object. Thus, despite the existence of “what” and “where” information in both pathways, visual representations may still differ fundamentally in the two pathways. PMID:28821655

Utilisation of health services and geography: deconstructing regional differences in barriers to facility-based delivery in Nepal.

PubMed

Hodge, Andrew; Byrne, Abbey; Morgan, Alison; Jimenez-Soto, Eliana

2015-03-01

While established that geographical inaccessibility is a key barrier to the utilisation of health services, it remains unknown whether disparities are driven only by limited access to these services, or are also attributable to health behaviour. Significant disparities exist in health outcomes and the coverage of many critical health services between the mountains region of Nepal and the rest of the country, yet the principal factors driving these regional disparities are not well understood. Using national representative data from the 2011 Nepal Demographic and Health Survey, we examine the extent to which observable factors explain the overall differences in the utilisation of maternal health services. We apply nonlinear Blinder-Oaxaca-type decomposition methods to quantify the effect that differences in measurable characteristics have on the regional coverage gap in facility-based delivery. The mean coverage of facility-based deliveries was 18.6 and 36.3 % in the mountains region and the rest of Nepal, respectively. Between 54.8 and 74.1 % of the regional coverage gap was explained by differences in observed characteristics. Factors influencing health behaviours (proxied by mothers' education, TV viewership and tobacco use, and household wealth) and subjective distance to the health facility were the major factors, contributing between 52.9 and 62.5 % of the disparity. Mothers' birth history was also noteworthy. Policies simultaneously addressing access and health behaviours appear necessary to achieve greater coverage and better health outcomes for women and children in isolated areas.

Child poverty and regional disparities in Turkey.

PubMed

Eryurt, Mehmet Ali; Koç, Ismet

2013-01-01

The United Nations Children's Fund (UNICEF) defines child poverty as the inability of the child to realize their existing potential due to their inability to access resources across different dimensions of life (income, health, nutrition, education, environment, etc.). On the basis of this definition, an attempt has been made in this study to put forth the disadvantaged positions children have in different dimensions of their lives, specifically by taking regional disparities into account. As the data source, the Turkey Demographic and Health Survey 2008 is used, a survey that consists of detailed information about the different dimensions of child poverty. In this study, in order to measure poverty in four different dimensions (education and work, health and nutrition, family environment, and domestic environment), a total of 25 variables were used and descriptive and multivariate analyses were made in order to highlight the regional disparities in child poverty. Principle components analysis conducted through the use of a deficit approach reveals that the variables closely related with education and health and nutrition were the critical dimensions behind child poverty in Turkey. The results of this study indicate that 22.4% of children in Turkey are poor when various dimensions of life are taken into account; the region with the highest child poverty is Central East Anatolia, at 34.9%, while the region with the lowest rate is East Marmara, at 15.6%.

Hydrological evolution of Atlantis basin, Sirenum Terrae, Mars. Preliminar analysis of MOC and THEMIS images.

NASA Astrophysics Data System (ADS)

de Pablo, M. A.; Márquez, A.; Centeno, J. D.

The Atlantis basin is one of the martian highlands areas where there was proposed the existence of an ancient lake during the early geological history of Mars [1] [2] [3] [4]. The existence of some morphological features inside the basin and in the surrounding area, allow to check the existence of liquid water in the past of the planet. On the other hand, other morphological features indicate the existence of snow and liquid groundwater in recent times. The detailed study of the geomorphologic features allows to make an approach to the hydrological evolution of the Atlantis basin. The study of the geomorphology of this region has been carried out by means of the analysis of MOC high resolution images obtained by the Mars Global Surveyor mission and the THEMIS images, in the visible spectrum, sent by Mars Odyssey spacecrafts. The most clearly morphological feature indicative of the existence of water in the surface of Mars in the past are the numerous channels that end into Atlantis basin from the highest terrains. In addiction to these fluvial channels, the existence of mass flow deposits is also indicative of the existence of water in the area. Some of these slumps are in the internal slopes of impact craters, but others cover huge extensions around the chaotic terrains of the studied area. The lobated ejecta deposits observed in the Atlantis basin region are indicative of the existence of groundwater (solid or liquid) [5]. Serrated reliefs and tables in the borders of the basins are indicative of the existence of a water sheet. Beneath this water sheet some deposits was formed which was eroded, due to the gradual desiccation of the basin, forming the tables and serrated reliefs. The existence of different chaotic terrains in the area implies the existence of huge amounts of water under the surface according to the different models of chaotic terrain formation [6] [7]. The existence of groundwater could be decided by the existence of collapses in the near to the chaotic terrain that it occupies the Atlantis basin centre [4]. Finally, the two features that indicate the existence of water in the most recent past of the basin are the gullies and icy dust surfaces. Gullies appears in the internal slopes of some impact craters located at the South of the Atlantis basin. Although different origins are discussed for the water that eroded these gullies [8] [9] [10] their formation implies the flow of water in surface during a relatively short time period. The mantels of icy dust have been described in several places of Mars and they imply the existence of frozen water in the most superficial layer [11] [12]. The low craterization of the deposits of the gullies and the icy dust surfaces indicates the extreme youth of these features. All these geomorphologic features show the existence of water in the surface or in subsurface of Mars in the region of the basin Atlantis in different moments of its geologic history. The previos studies of the MOLA topographic data (Mars Global Surveyor) [3] [13] indicate that this basin is part of the great Eridania Lake [3] whose gradual drying originated the formation of small lakes, one of them, the Atlantis lake [4], was located inside the studied basin. The fluvial channels observed in the edges of the basin should contribute with some water to this lake. The hypothesis of existence of a lake is supported by the existence of tables and serrated reliefs formed during the descent of the water sheet. The formation of the chaotic terrain, collapse areas, lobated ejecta of some impact craters and the mass flow deposits, all indicate the existence of water in the subsurface after the disappearance of the Atlantis Lake. Finally, the gullies and the icy dust surfaces indicate that water still exists at different depths in the ground. [1] Parker, T.J., Currey, D.R. 2001. Geomorphology, 37. 303-328. [2] de Pablo, M.A., Druet, M. 2002. XXXIII LPSC, Abstract #1032. [3] Irwin, R.P., et al. 2002. Science, 297, 2209-2212. [4] de Pablo, M.A., et al. 2004. XXXV LPSC, Abstracts. #1223. [5] Carr, 1996. Oxford University Press, New York. 229 p. [6] Komatsu, G. et al. 2000. XXXI LPSC, abstract # 1434. [7] Oyawa, Y., et al 2003. VI Int. Mars Conf., Abstract #3095. [8] Malin, M.C., Edgett, K.S. 2000. Science, 288. 2330-2335. [9] Costard, F., et al. 2002. Science, 295. 110-113. [10] Gilmore, M.S., Phillips, E.L. 2002. J. Gepphys. Res., 30. 1107-1110. [11] Mustard, J.F., et al. 2001. Nature, 412. 411-414. [12] Milliken, R.E., et al. 2003. J. Geophys. Res., 108 (E6). 5057. doi:10.1029/2002JE002005. [13] de Pablo, M.A. 2003. VI Internacional Conference on Mars, Abstract #3037.

Effects of triclosan on aquatic invertebrates in tropics and the influence of pH on its toxicity on microalgae.

PubMed

Khatikarn, Jidapa; Satapornvanit, Kriengkrai; Price, Oliver R; Van den Brink, Paul J

2018-05-01

The antimicrobial triclosan (TCS) has been detected in household wastewaters (untreated and treated) and receiving environments across the globe. The toxic effects of TCS on temperate standard aquatic test organisms have been widely reported with microalgae being the most sensitive. However, environmental differences between tropical and temperate regions may have selected different trait compositions between these two regions, which in turn may lead to a difference in species sensitivity. Therefore, additional information is required to better characterize risks to organisms in tropics and ensure biodiversity in these regions is not adversely impacted. This study aims to supplement existing TCS toxicity data with five aquatic invertebrates found in tropics and to compare the sensitivity between aquatic invertebrate species from tropical and temperate regions. In addition, the effect of pH on the toxicity of neutral and ionized forms of TCS to microalgae (Chlorella ellipsoidea) was investigated. The reported 96-h LC50 values for the studied invertebrate species ranged from 72 to 962 μg/L. There was no significant difference between the sensitivity of aquatic invertebrate species from tropical and temperate regions. EC50 values for C. ellipsoidea, with and without pH buffer, were significantly different. The findings of this study can be used to support site-specific water quality criteria and environmental risk assessment for TCS in tropical regions. However, further chronic and semi-field experiments with TCS could potentially enable a refined assessment of direct and indirect effects on tropical aquatic communities and further explore functional endpoints of tropical ecosystems.

Musical taste, employment, education, and global region.

PubMed

North, Adrian C; Davidson, Jane W

2013-10-01

Sociologists have argued that musical taste should vary between social groups, but have not considered whether the effect extends beyond taste into uses of music and also emotional reactions to music. Moreover, previous research has ignored the culture in which participants are located. The present research employed a large sample from five post-industrial global regions and showed that musical taste differed between regions but not according to education and employment; and that there were three-way interactions between education, employment, and region in the uses to which participants put music and also their typical emotional reactions. In addition to providing partial support for existing sociological theory, the findings highlight the potential of culture as a variable in future quantitative research on taste. © 2013 The Scandinavian Psychological Associations.

Increased in Variability in Climatological Means and Extremes in the Great Plains

NASA Astrophysics Data System (ADS)

Basara, J. B.; Flanagan, P. X.; Christian, J.; Christian, K.

2016-12-01

The Great Plains (GP) of North America is characterized by orthogonal gradients of temperature and precipitation extending from the Gulf of Mexico in the south to the coniferous forests of Canada to the north and are bordered on the west by the Rocky Mountains and then spread east approximately 1000 km into the interior regions of North America. As a result, significant biodiversity exists across relatively short distances within the region. However, because the gradient of precipitation is large across the GP, multiple environmental factors can lead to significant variability in temperature and precipitation at periods spanning seasonal, to interannual, to decadal scales. In addition, the GP region has shown significant coupling between the surface and the atmosphere, especially during the warm season. As a result, the GP often experiences significant hydrometeorological and hydroclimatological extremes across varying spatial and temporal scales including long-term drought, flash drought, flash flooding, and long-term pluvial periods with significant impacts to ecosystem function. Results into analyses of drought to pluvial dipole events in the GP noted that on average, over twice as many dipoles existed in the latter half of the dataset (1955-2013) relative to the first half (1896-1954). In addition an Asynchronous Difference Index (ADI) computed by determining the difference between the dates of precipitation and temperature maxima revealed two physically distinct regimes of ADI (positive and negative), with comparable shifts in the timing of both the maximum of precipitation and temperature within the GP. Time series analysis of decadal average ADI yielded moderate shifts in ADI with increased variability occurring over much of the GP region.

Assessing models of arsenic occurrence in drinking water from bedrock aquifers in New Hampshire

USGS Publications Warehouse

Andy, Caroline; Fahnestock, Maria Florencia; Lombard, Melissa; Hayes, Laura; Bryce, Julie; Ayotte, Joseph

2017-01-01

Three existing multivariate logistic regression models were assessed using new data to evaluate the capacity of the models to correctly predict the probability of groundwater arsenic concentrations exceeding the threshold values of 1, 5, and 10 micrograms per liter (µg/L) in New Hampshire, USA. A recently released testing dataset includes arsenic concentrations from groundwater samples collected in 2004–2005 from a mix of 367 public-supply and private domestic wells. The use of this dataset to test three existing logistic regression models demonstrated enhanced overall predictive accuracy for the 5 and 10 μg/L models. Overall accuracies of 54.8, 76.3, and 86.4 percent were reported for the 1, 5, and 10 μg/L models, respectively. The state was divided by counties into northwest and southeast regions. Regional differences in accuracy were identified; models had an average accuracy of 83.1 percent for the counties in the northwest and 63.7 percent in the southeast. This is most likely due to high model specificity in the northwest and regional differences in arsenic occurrence. Though these models have limitations, they allow for arsenic hazard assessment across the region. The introduction of well-type (public or private), well depth, and casing length as explanatory variables may be appropriate measures to improve model performance. Our findings indicate that the original models generalize to the testing dataset, and should continue to serve as an important vehicle of preventative public health that may be applied to other groundwater contaminants in New Hampshire.

Spatio-temporal organization of dynamics in a two-dimensional periodically driven vortex flow: A Lagrangian flow network perspective.

PubMed

Lindner, Michael; Donner, Reik V

2017-03-01

We study the Lagrangian dynamics of passive tracers in a simple model of a driven two-dimensional vortex resembling real-world geophysical flow patterns. Using a discrete approximation of the system's transfer operator, we construct a directed network that describes the exchange of mass between distinct regions of the flow domain. By studying different measures characterizing flow network connectivity at different time-scales, we are able to identify the location of dynamically invariant structures and regions of maximum dispersion. Specifically, our approach allows us to delimit co-existing flow regimes with different dynamics. To validate our findings, we compare several network characteristics to the well-established finite-time Lyapunov exponents and apply a receiver operating characteristic analysis to identify network measures that are particularly useful for unveiling the skeleton of Lagrangian chaos.

THE POSSIBLE IMPACT OF L5 MAGNETOGRAMS ON NON-POTENTIAL SOLAR CORONAL MAGNETIC FIELD SIMULATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weinzierl, Marion; Yeates, Anthony R.; Mackay, Duncan H.

The proposed Carrington-L5 mission would bring instruments to the L5 Lagrange point to provide us with crucial data for space weather prediction. To assess the importance of including a magnetograph, we consider the possible differences in non-potential solar coronal magnetic field simulations when magnetograph observations are available from the L5 point, compared with an L1-based field of view (FOV). A timeseries of synoptic radial magnetic field maps is constructed to capture the emergence of two active regions from the L5 FOV. These regions are initially absent in the L1 magnetic field maps, but are included once they rotate into themore » L1 FOV. Non-potential simulations for these two sets of input data are compared in detail. Within the bipolar active regions themselves, differences in the magnetic field structure can exist between the two simulations once the active regions are included in both. These differences tend to reduce within 5 days of the active region being included in L1. The delayed emergence in L1 can, however, lead to significant persistent differences in long-range connectivity between the active regions and the surrounding fields, and also in the global magnetic energy. In particular, the open magnetic flux and the location of open magnetic footpoints, are sensitive to capturing the real-time of emergence. These results suggest that a magnetograph at L5 could significantly improve predictions of the non-potential corona, the interplanetary magnetic field, and of solar wind source regions on the Sun.« less

Comparing Volume Loss in Neuroanatomical Regions of Emotion versus Regions of Cognition in Healthy Aging.

PubMed

Pressman, Peter S; Noniyeva, Yuliana; Bott, Nick; Dutt, Shubir; Sturm, Virginia; Miller, Bruce L; Kramer, Joel H

2016-01-01

Many emotional functions are relatively preserved in aging despite declines in several cognitive domains and physical health. High levels of happiness exist even among centenarians. To address the hypothesis of whether preservation of emotional function in healthy aging may relate to different rates of age-related volume loss across brain structures, we performed two volumetric analyses on structural magnetic resonance neuroimaging of a group of healthy aging research participants using Freesurfer version 5.1. Volumes selected as supporting cognition included bilateral midfrontal and lateral frontal gyri, lateral parietal and temporal cortex, and medial temporal lobes. Volumes supporting emotion included bilateral amygdala, rostral anterior cingulate, insula, orbitofrontal cortex, and nucleus accumbens. A cross-sectional analysis was performed using structural MRI scans from 258 subjects. We found no difference in proportional change between groups. A longitudinal mixed effects model was used to compare regional changes over time in a subset of 84 subjects. Again, there was no difference in proportional change over time. While our results suggest that aging does not collectively target cognitive brain regions more than emotional regions, subgroup analysis suggests relative preservation of the anterior cingulate cortex, with greater volume loss in the nucleus accumbens. Implications of these relative rates of age-related volume loss in healthy aging are discussed and merit further research.

Characterisation of regional skin temperatures in recreational surfers wearing a 2-mm wetsuit.

PubMed

Corona, Luis J; Simmons, Grant H; Nessler, Jeff A; Newcomer, Sean C

2018-05-01

The purpose of this study was to investigate skin temperatures across surfers' bodies while wearing a wetsuit during recreational surfing. Forty-six male recreational surfers participated in this study. Participants were instrumented with eight wireless iButton thermal sensors for the measurement of skin temperature, a Polar RCX5 heart rate monitor and a 2-mm full wetsuit. Following instrumentation, participants were instructed to engage in recreational surfing activities as normal. Significant differences (p < 0.001) in skin temperature (T sk ) were found across the body while wearing a wetsuit during recreational surfing. In addition, regional skin temperature changed across the session for several regions of the body (p < 0.001), and the magnitude of these changes varied significantly between regions. We show for the first time that significant differences exist in skin temperature across the body while wearing a wetsuit during a typical recreational surfing session. These findings may have implications for future wetsuit design. Practitioner Summary: This study investigated the impact of wearing a wetsuit during recreational surfing on regional skin temperatures. Results from this study suggest that skin temperatures differ significantly across the body while wearing a 2-mm wetsuit during recreational surfing. These findings may have implications for future wetsuit design.

Seroprevalence of Toxoplasma gondii infection in goats and sheep in Zimbabwe.

PubMed

Hove, T; Lind, P; Mukaratirwa, S

2005-12-01

Seroprevalence rates of Toxoplasma gondii anti-antibodies in adult goats and sheep from different parts of Zimbabwe were determined. A total of 225 (67.9%) of the 335 serum samples tested were positive for anti-T. gondii IgG antibodies with the indirect fluorescent antibody test. There were differences in antibody seroprevalences among communal land goats from the different agro-ecological zones (Natural regions llb and III: 80 and 96.7%, respectively; Natural region IV: 65.9%; Natural region V: 45%; and Natural region III had a significantly higher seroprevalence than IV and V. The highest seroprevalences found in Natural regions II b and Ill are likely to be linked to the existence of more households and hence the possibility of a higher concentration of domestic cats that increases the chances of environmental contamination with their faeces harbouring T. gondii oocysts. The seroprevalence rate in sheep from a large commercial farm (10%) was significantly lower than that of sheep reared under the communal grazing system (80%). Overall, significantly higher proportions of seropositive animals had antibody titres of 1:50 (34.2% of 225) and 1:100 (44% of 225) as compared to the 9.8% and 12% with antibody titres of 1:200 and > or =1:400, respectively.

Characterizing the Associative Content of Brain Structures Involved in Habitual and Goal-Directed Actions in Humans: A Multivariate fMRI Study

PubMed Central

Liljeholm, Mimi; Zika, Ondrej; O'Doherty, John P.

2015-01-01

While there is accumulating evidence for the existence of distinct neural systems supporting goal-directed and habitual action selection in the mammalian brain, much less is known about the nature of the information being processed in these different brain regions. Associative learning theory predicts that brain systems involved in habitual control, such as the dorsolateral striatum, should contain stimulus and response information only, but not outcome information, while regions involved in goal-directed action, such as ventromedial and dorsolateral prefrontal cortex and dorsomedial striatum, should be involved in processing information about outcomes as well as stimuli and responses. To test this prediction, human participants underwent fMRI while engaging in a binary choice task designed to enable the separate identification of these different representations with a multivariate classification analysis approach. Consistent with our predictions, the dorsolateral striatum contained information about responses but not outcomes at the time of an initial stimulus, while the regions implicated in goal-directed action selection contained information about both responses and outcomes. These findings suggest that differential contributions of these regions to habitual and goal-directed behavioral control may depend in part on basic differences in the type of information that these regions have access to at the time of decision making. PMID:25740507

User’s guide and metada for the PICES Nonindigenous Species Information System

USGS Publications Warehouse

Lee,; Reusser, Deborah A.; Marko,; Ranelletti,

2012-01-01

The overall goal of both the database and Atlas was to simplify and standardize the dissemination of distributional, habitat, and life history characteristics of near-coastal and estuarine nonindigenous species. This database provides a means of querying these data and displaying the information in a consistent format. The specific classes of information the database captures include: Regional and global ranges of native and nonindigenous near-coastal and estuarine species at different hierarchical spatial scales. Habitat and physiological requirements of near-coastal and estuarine species. Life history characteristics of near-coastal and estuarine species. Invasion history and vectors for nonindigenous species. This standardized and synthesized data in the database and the Atlas provide the basic information needed to address a number of managerial and scientific needs. Thus, users will be able to: Create a baseline on the extent of invasion by region in order to assess new invasions. Use existing geographical patterns of invasion to gain some insights into potential new invaders. Use existing geographical patters of invasion to gain some insights into mechanisms affecting relative invasibility of different areas. Use life history attributes and environmental requirements of the reported nonindigenous species to evaluate traits of invaders. Understand the potential spread of invaders based on their habitat and environmental requirements. Understand importance of different vectors of introduction of nonindigenous species by region. The data in the Atlas of Nonindigenous Marine and Estuarine Species in the North Pacific (Lee and Reusser, 2012) are up-to-date as of June 2012. Updates to the PICES database were made in September 2012. 

Field Test of a Hybrid Finite-Difference and Analytic Element Regional Model.

PubMed

Abrams, D B; Haitjema, H M; Feinstein, D T; Hunt, R J

2016-01-01

Regional finite-difference models often have cell sizes that are too large to sufficiently model well-stream interactions. Here, a steady-state hybrid model is applied whereby the upper layer or layers of a coarse MODFLOW model are replaced by the analytic element model GFLOW, which represents surface waters and wells as line and point sinks. The two models are coupled by transferring cell-by-cell leakage obtained from the original MODFLOW model to the bottom of the GFLOW model. A real-world test of the hybrid model approach is applied on a subdomain of an existing model of the Lake Michigan Basin. The original (coarse) MODFLOW model consists of six layers, the top four of which are aggregated into GFLOW as a single layer, while the bottom two layers remain part of MODFLOW in the hybrid model. The hybrid model and a refined "benchmark" MODFLOW model simulate similar baseflows. The hybrid and benchmark models also simulate similar baseflow reductions due to nearby pumping when the well is located within the layers represented by GFLOW. However, the benchmark model requires refinement of the model grid in the local area of interest, while the hybrid approach uses a gridless top layer and is thus unaffected by grid discretization errors. The hybrid approach is well suited to facilitate cost-effective retrofitting of existing coarse grid MODFLOW models commonly used for regional studies because it leverages the strengths of both finite-difference and analytic element methods for predictions in mildly heterogeneous systems that can be simulated with steady-state conditions. © 2015, National Ground Water Association.

Genomic regions in crop–wild hybrids of lettuce are affected differently in different environments: implications for crop breeding

PubMed Central

Hartman, Yorike; Hooftman, Danny A P; Uwimana, Brigitte; van de Wiel, Clemens C M; Smulders, Marinus J M; Visser, Richard G F; van Tienderen, Peter H

2012-01-01

Many crops contain domestication genes that are generally considered to lower fitness of crop–wild hybrids in the wild environment. Transgenes placed in close linkage with such genes would be less likely to spread into a wild population. Therefore, for environmental risk assessment of GM crops, it is important to know whether genomic regions with such genes exist, and how they affect fitness. We performed quantitative trait loci (QTL) analyses on fitness(-related) traits in two different field environments employing recombinant inbred lines from a cross between cultivated Lactuca sativa and its wild relative Lactuca serriola. We identified a region on linkage group 5 where the crop allele consistently conferred a selective advantage (increasing fitness to 212% and 214%), whereas on linkage group 7, a region conferred a selective disadvantage (reducing fitness to 26% and 5%), mainly through delaying flowering. The probability for a putative transgene spreading would therefore depend strongly on the insertion location. Comparison of these field results with greenhouse data from a previous study using the same lines showed considerable differences in QTL patterns. This indicates that care should be taken when extrapolating experiments from the greenhouse, and that the impact of domestication genes has to be assessed under field conditions. PMID:23028403

9 CFR 94.8 - Pork and pork products from regions where African swine fever exists or is reasonably believed to...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Pork and pork products from regions where African swine fever exists or is reasonably believed to exist. 94.8 Section 94.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND...

9 CFR 94.8 - Pork and pork products from regions where African swine fever exists or is reasonably believed to...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Pork and pork products from regions where African swine fever exists or is reasonably believed to exist. 94.8 Section 94.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND...

Possible existence of wormholes in the central regions of halos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rahaman, Farook, E-mail: rahaman@iucaa.ernet.in; Salucci, P., E-mail: salucci@sissa.it; INFN, Sezione di Trieste, Via Valerio 2, 34127, Trieste

2014-11-15

An earlier study (Rahaman, et al., 2014 and Kuhfittig, 2014) has demonstrated the possible existence of wormholes in the outer regions of the galactic halo, based on the Navarro–Frenk–White (NFW) density profile. This paper uses the Universal Rotation Curve (URC) dark matter model to obtain analogous results for the central parts of the halo. This result is an important compliment to the earlier result, thereby confirming the possible existence of wormholes in most of the spiral galaxies. - Highlights: • Earlier we showed possible existence of wormholes in the outer regions of halo. • We obtain here analogous results for themore » central parts of the galactic halo. • Our result is an important compliment to the earlier result. • This confirms possible existence of wormholes in most of the spiral galaxies.« less

Towards machine ecoregionalization of Earth's landmass using pattern segmentation method

NASA Astrophysics Data System (ADS)

Nowosad, Jakub; Stepinski, Tomasz F.

2018-07-01

We present and evaluate a quantitative method for delineation of ecophysiographic regions throughout the entire terrestrial landmass. The method uses the new pattern-based segmentation technique which attempts to emulate the qualitative, weight-of-evidence approach to a delineation of ecoregions in a computer code. An ecophysiographic region is characterized by homogeneous physiography defined by the cohesiveness of patterns of four variables: land cover, soils, landforms, and climatic patterns. Homogeneous physiography is a necessary but not sufficient condition for a region to be an ecoregion, thus machine delineation of ecophysiographic regions is the first, important step toward global ecoregionalization. In this paper, we focus on the first-order approximation of the proposed method - delineation on the basis of the patterns of the land cover alone. We justify this approximation by the existence of significant spatial associations between various physiographic variables. Resulting ecophysiographic regionalization (ECOR) is shown to be more physiographically homogeneous than existing global ecoregionalizations (Terrestrial Ecoregions of the World (TEW) and Bailey's Ecoregions of the Continents (BEC)). The presented quantitative method has an advantage of being transparent and objective. It can be verified, easily updated, modified and customized for specific applications. Each region in ECOR contains detailed, SQL-searchable information about physiographic patterns within it. It also has a computer-generated label. To give a sense of how ECOR compares to TEW and, in the U.S., to EPA Level III ecoregions, we contrast these different delineations using two specific sites as examples. We conclude that ECOR yields regionalization somewhat similar to EPA level III ecoregions, but for the entire world, and by automatic means.

A method for evaluating the importance of system state observations to model predictions, with application to the Death Valley regional groundwater flow system

USGS Publications Warehouse

Tiedeman, Claire; Ely, D. Matthew; Hill, Mary C.; O'Brien, Grady M.

2004-01-01

We develop a new observation‐prediction (OPR) statistic for evaluating the importance of system state observations to model predictions. The OPR statistic measures the change in prediction uncertainty produced when an observation is added to or removed from an existing monitoring network, and it can be used to guide refinement and enhancement of the network. Prediction uncertainty is approximated using a first‐order second‐moment method. We apply the OPR statistic to a model of the Death Valley regional groundwater flow system (DVRFS) to evaluate the importance of existing and potential hydraulic head observations to predicted advective transport paths in the saturated zone underlying Yucca Mountain and underground testing areas on the Nevada Test Site. Important existing observations tend to be far from the predicted paths, and many unimportant observations are in areas of high observation density. These results can be used to select locations at which increased observation accuracy would be beneficial and locations that could be removed from the network. Important potential observations are mostly in areas of high hydraulic gradient far from the paths. Results for both existing and potential observations are related to the flow system dynamics and coarse parameter zonation in the DVRFS model. If system properties in different locations are as similar as the zonation assumes, then the OPR results illustrate a data collection opportunity whereby observations in distant, high‐gradient areas can provide information about properties in flatter‐gradient areas near the paths. If this similarity is suspect, then the analysis produces a different type of data collection opportunity involving testing of model assumptions critical to the OPR results.

The CEOP Inter-Monsoon Studies (CIMS)

NASA Technical Reports Server (NTRS)

Lau, William K. M.

2003-01-01

Prediction of climate relies on models, and better model prediction depends on good model physics. Improving model physics requires the maximal utilization of climate data of the past, present and future. CEOP provides the first example of a comprehensive, integrated global and regional data set, consisting of globally gridded data, reference site in-situ observations, model location time series (MOLTS), and integrated satellite data for a two-year period covering two complete annual cycles of 2003-2004. The monsoon regions are the most important socio-economically in terms of devastation by floods and droughts, and potential impacts from climate change md fluctuatinns nf the hydrologic cyc!e. Scientifically, it is most challenging, because of complex interactions of atmosphere, land and oceans, local vs. remote forcings in contributing to climate variability and change in the region. Given that many common features, and physical teleconnection exist among different monsoon regions, an international research focus on monsoon must be coordinated and sustained. Current models of the monsoon are grossly inadequate for regional predictions. For improvement, models must be confronted with relevant observations, and model physic developers must be made to be aware of the wealth of information from existing climate data, field measurements, and satellite data that can be used to improve models. Model transferability studles must be conducted. CIMS is a major initiative under CEOP to engage the modeling and the observational communities to join in a coordinated effort to study the monsoons. The objectives of CIMS are (a) To provide a better understanding of fundamental physical processes (diurnal cycle, annual cycle, and intraseasonal oscillations) in monsoon regions around the world and (b) To demonstrate the synergy and utility of CEOP data in providing a pathway for model physics evaluation and improvement. In this talk, I will present the basic concepts of CIMS and the key scientific problems facing monsoon climates and provide examples of common monsoon features, and possible monsoon induced teleconnections linking different parts of the world.

Intraocular distribution of melanin in human, monkey, rabbit, minipig and dog eyes.

PubMed

Durairaj, Chandrasekar; Chastain, James E; Kompella, Uday B

2012-05-01

The purpose of this study was to quantify the melanin pigment content in sclera, choroid-RPE, and retina, three tissues encountered during transscleral drug delivery to the vitreous, in human, rabbit, monkey, minipig, and dog models. Strain differences were assessed in NZW × NZR F1 and Dutch belted rabbits and Yucatan and Gottingen minipigs. The choroid-RPE and retina tissues were divided into central (posterior pole area) and peripheral (away from posterior pole) regions while the sclera was analyzed without such division. Melanin content in the tissues was analyzed using a colorimetric assay. In all species the rank order for pigment content was: choroid-RPE >retina ≥ sclera, except in humans, where scleral melanin levels were higher than retina and central choroid. The melanin content in a given tissue differed between species. Further, while the peripheral tissue pigment levels tended to be generally higher compared to the central regions, these differences were significant in human in the case of choroid-RPE and in human, monkey, and dogs in the case of retina. Strain difference was observed only in the central choroid-RPE region of rabbits (NZW × NZR F1 >Dutch Belted). Species, strain, and regional differences exist in the melanin pigment content in the tissues of the posterior segment of the eye, with Gottingen minipig being closest to humans among the animals assessed. These differences in melanin content might contribute to differences in drug binding, delivery, and toxicity. Copyright © 2012 Elsevier Ltd. All rights reserved.

LandCaRe-DSS - model based tools for irrigation management under climate change

NASA Astrophysics Data System (ADS)

Dotterweich, Markus; Wilkinson, Kristina; Cassel, Martin; Scherzer, Jörg; Köstner, Barbara; Berg, Michael; Grocholl, Jürgen

2015-04-01

Climate change is expected to have a strong influence on agricultural systems in the future. It will be important for decision makers and stakeholders to assess the impact of climate change at the farm and regional level in order to facilitate and maintain a sustainable and profitable farming infrastructure. Climate change impact studies have to incorporate aspects of uncertainty and the underlying knowledge is constantly expanding and improving. Decision support systems (DSS) with flexible data bases are therefore a useful tool for management and planning: different models can be applied under varying boundary conditions within a conceptual framework and the results can be used e.g. to show the effects of climate change scenarios and different land management options. Within this project, the already existing LandCaRe DSS will be further enhanced and improved. A first prototype had been developed for two regions in eastern Germany, mainly to show the effects of climate change on yields, nutrient balances and farm economy. The new model version will be tested and applied for a region in north-western Germany (Landkreis Uelzen) where arable land makes up about 50% of overall land-use and where 80 % of the arable land is already irrigated. For local decision makers, it will be important to know how water demand and water availability are likely to change in the future: Is more water needed for irrigation? Is more water actually available for irrigation? Will the existing limits for ground water withdrawal be sufficient for farmers to irrigate their crops? How can the irrigation water demand be influenced by land management options like the use of different crops and varieties or different farming and irrigation techniques? The main tasks of the project are (I) the integration of an improved irrigation model, (II) the development of a standardized interface to apply the DSS in different regions, (III) to optimize the graphical user interface, (IV) to transfer and apply the DSS in an example region in north-west Germany and (V) to expand the underlying data base of climate change models and scenarios. The project is funded by the Bundesministeriums für Bildung und Forschung (BMBF), Förderkennzeichen Förderkennzeichen: 02WQ1304.

Sociocultural, Environmental, and Health Challenges Facing Women and Children Living Near the Borders Between Afghanistan, Iran, and Pakistan (AIP Region)

PubMed Central

Poureslami, Iraj M; MacLean, David R; Spiegel, Jerry; Yassi, Annalee

2004-01-01

Background For hundred of years, people in the region encompassed by the Afghanistan-Iran-Pakistan borders (AIP region) have been challenged by conflict and political and civil instability, mass displacement, human rights abuses, drought, and famine. It not surprising that health and quality of life of vulnerable groups in this region are among the worst in the world. In general, women and children, in particular girls, in the AIP region have had especially limited access to healthcare. Women and children have dramatically high rates of communicable and non-communicable disease, morbidity, and mortality and a general low life expectancy that is rapidly declining. In spite of national and international efforts to improve health status of vulnerable populations in this region, the key underlying sociocultural determinants of health and disparities (ie, gender, language, ethnicity, residential status, and socioeconomic status) have not been systematically studied, nor have their relationships to environmental challenges been examined. Objectives We set out to summarize existing information regarding the sociocultural, environmental, and traditional determinants of health disparities among different population groups in the AIP region; identify gaps in research regarding the communities' needs in the region; and highlight factors that must be considered in the design and implementation of future health intervention studies in the region. Methods We reviewed current health literature, official documents, and other information (eg, reports of UN agencies) related to the social, cultural, and environmental factors that may influence the health outcomes of subpopulations living in the AIP region. We also interviewed individuals who had recently worked in this region. Results Overall, the health problems faced by this underdeveloped region can be categorized into those resulting from lack of essential supplies and services and those stemming from the existing cultural practices in the area. The low health status of the people, particularly women and children, in the AIP region is associated with not only poor hygiene and lack of water but also limited knowledge and lack of access to healthcare services. In addition, cultural, political, and socioenvironmental factors play a role, including gender inequality and differences between languages spoken locally in the region and those most often used in written health education materials. Conclusion Future intervention programs designed for this region must use culturally sensitive strategies not only to provide health information and health services but also to address the underlying nonmedical determinants of health related to gender inequalities PMID:15520675

POP emission inventories on different scales and their future trends

NASA Astrophysics Data System (ADS)

Theloke, Jochen; Breivik, Knut; Denier van der Gon, Hugo; Kugler, Ulrike; Li, Yi-Fan; Pacyna, Jozef; Panasiuk, Damian; Sundseth, Kyrre; Sweetman, Andy; Tao, Shu

2010-05-01

Persistent organic pollutants (POPs) are defined as organic substances that possess toxic characteristics; are persistent; bioaccumulate; are prone to long-range transboundary atmospheric transport and deposition; and are likely to cause significant adverse human health or environmental effects near to and distant from their sources. To reduce these adverse effects and for monitoring the effectiveness of existing international agreements, esp. UNECE-POP and UNEP protocols, concerning POPs the compilation of emission inventories is required. This presentation addresses emission inventories for POPs which are covered by existing protocols as well as candidate substances which are in focus for the revision of the international protocols. The following substances will be taken into account in this presentation: Dioxins and Furans (PCDD/F), PAHs, PCBs, Hexachlorbenzene (HCB), Pesticides (e.g. HCH, Dicofol and Endosulfan), Perfluoroctansulfonate (PFOS) and Polybrominated Diphenylethers (PBDEs), Hexachlorobutadiene (HCBD), Pentachlorobenzene (PeCB), Polychlorinated Naphthalenes (PCN), and Pentachlorophenols (PCPs). For all considered substances emission inventories exist with different qualities, from preliminary estimates to more complete inventories. These inventories are based on different methodologies (measurements, modelling, mass balance approaches, etc.), cover different regions (Europe, North America, Asia, China) and different spatial scales (regional, global) with different spatial resolutions. An overview will be given of the current state of the knowledge through a description of the main sources for the specific pollutants, the recent emission levels, a description of historical emission (incl. time series) and gridded data bases, if available. Furthermore, recommendations to improve POP emission inventories as well as major obstacles to achieve these improvements will be given. A further focus of this presentation will be an overview of future trends of specific POPs, e. g. PCB and PCDD/F until 2050, with special emphasis on the different approaches for compilation of future scenarios for specific substances. The following key questions concerning compilation of projections will be considered here: Do we have sufficient data on emissions and the trends in driving forces needed for making reasonable future projections? How might emission quantities and spatial distributions change over the next 20 to 50 years? How will different source categories change?

Mapping telemedicine efforts: surveying regional initiatives in Denmark.

PubMed

Kierkegaard, Patrick

2015-05-01

The aim of this study is to survey telemedicine services currently in operation across Denmark. The study specifically seeks to answer the following questions: What initiatives are deployed within the different regions? What are the motivations behind the projects? What technologies are being utilized? What medical disciplines are being supported using telemedicine systems? All data were surveyed from the Telemedicinsk Landkort, a newly created database designed to provide a comprehensive and systematic overview of all telemedicine technologies in Denmark. The results of this study suggest that a growing numbers of telemedicine initiatives are currently in operation across Denmark but that considerable variations exist in terms of regional efforts as the number of operational telemedicine projects varied from region to region. The results of this study provide a timely picture of the factors that are shaping the telemedicine landscape of Denmark and suggest potential strategies to help policymakers increase and improve national telemedicine deployment.

Social Networks and Well-being: A Comparison of Older People in Mediterranean and Non-Mediterranean Countries

PubMed Central

2010-01-01

Objectives. This study examined whether the social networks of older persons in Mediterranean and non-Mediterranean countries were appreciably different and whether they functioned in similar ways in relation to well-being outcomes. Methods. The sample included family household respondents aged 60 years and older from the first wave of the Survey of Health, Ageing and Retirement in Europe in 5 Mediterranean (n = 3,583) and 7 non-Mediterranean (n = 5,471) countries. Region was regressed separately by gender on variables from 4 network domains: structure and interaction, exchange, engagement and relationship quality, and controlling for background and health characteristics. In addition, 2 well-being outcomes—depressive symptoms and perceived income inadequacy—were regressed on the study variables, including regional social network interaction terms. Results. The results revealed differences across the 2 regional settings in each of the realms of social network, above and beyond the differences that exist in background characteristics and health status. The findings also showed that the social network variables had different effects on the well-being outcomes in the respective settings. Discussion. The findings underscore that the social network phenomenon is contextually bound. The social networks of older people should be seen within their unique regional milieu and in relation to the values and social norms that prevail in different sets of societies. PMID:20008485

A Further Evaluation of Bridge Roles: Regional and National Organizations for Dissemination of Computer-Oriented Curriculum Materials for Higher Education.

ERIC Educational Resources Information Center

Dank, Joseph R.

Several things must be done before a critical mass of computer-based materials can form a library. Existing materials must be upgraded, and made accessible, flexible and customized for individual users. Their mobility must be increased by reconciling inter-system differences and by providing necessary skills, resources and reward structures.…

Socio-Economic Segregation of Disadvantaged Children between Schools in Pakistan: Comparing the State and Private Sector

ERIC Educational Resources Information Center

Siddiqui, Nadia

2017-01-01

The distribution of children in different school-types and regions in Pakistan suggests that access and opportunities in education are not evenly accessible for many children. Segregation at school level is an important concern for equity and social justice because the adverse effects of segregation increase the pre-existing gap in opportunities…

Motives of Volunteering and Values of Work among Higher Education Students

ERIC Educational Resources Information Center

Bocsi, Veronika; Fényes, Hajnalka; Markos, Valéria

2017-01-01

In this article, the motives for voluntary work and work values in higher education contexts are examined in a cross-border region in Central Eastern Europe. Our goal is to find out what kind of relationship exists between different types of volunteering and work values among young people. In the theoretical section, we deal with the definition of…

Spanning the Chasm: A Blueprint for Action. Academic & Corporate Collaboration: Key to Preparing Tomorrow's High-Performance Workforce.

ERIC Educational Resources Information Center

Business-Higher Education Forum, Washington, DC.

This report presents ideas on the campus to workplace transition gathered from five regional workshops conducted in 1998-99. It notes that although business and higher education agree on the importance of changes in this transition, major differences exist between how these two sectors propose to accomplish such improvements. The workshops suggest…

Difference Does Not Mean Deficient: The Cultural and Higher Education Experiences of Appalachian Women

ERIC Educational Resources Information Center

Welch, Andrea D.

2013-01-01

The link between women in poverty and higher education is important because it reflects inequities in access and resources that exist in the Mid-Atlantic Appalachian region. Two main questions guided the research of women in poverty in regard to postsecondary access and attainment. First, what are the experiences of Mid-Atlantic Appalachian-born…

Knowledge and Morality of School-Age Children and Adolescents Regarding Environmental Issues and Moral Dilemmas

ERIC Educational Resources Information Center

Vestena, Carla Luciane Blum; Piske, Fernanda Hellen Ribeiro

2017-01-01

A research gap exists with regard to the analysis of school children and adolescents' awareness on environmental issues. Current investigation analyzes data of 240 children and adolescents, aged between 8 and 14 years, within different school contexts in the mid-southern region of Brazil, on their knowledge level and moral judgment on solid…

Effects of proline cis-trans isomerization on TB domain secondary structure.

PubMed Central

Yuan, X.; Werner, J. M.; Knott, V.; Handford, P. A.; Campbell, I. D.; Downing, K.

1998-01-01

The transforming growth factor beta (TGF-beta) binding protein-like (TB) domain is found principally in proteins localized to extracellular matrix fibrils, including human fibrillin-1, the defective protein in the Marfan syndrome. Analysis of the nuclear magnetic resonance (NMR) data for the sixth TB module from human fibrillin-1 has revealed the existence of two stable conformers that differ in the isomerization states of two proline residues. Unusually, the two isoforms do not readily interconvert and are stable on the time scale of milliseconds. We have computed independent structures of the major and minor conformers of TB6 to assess how the domain fold adjusts to incorporate alternatively cis- or trans-prolines. Based on previous observations, it has been suggested that multiple conformers can only be accommodated in flexible regions of protein structure. In contrast, P22, which exists in trans in the major form and cis in the minor form of TB6, is in a rigid region of the domain, which is confirmed by backbone dynamics measurements. Overall, the structures of the major and minor conformers are similar. However, the secondary structure topologies of the two forms differ as a direct consequence of the changes in proline conformation. PMID:9792099

Global Prevalence of Autism and Other Pervasive Developmental Disorders

PubMed Central

Elsabbagh, Mayada; Divan, Gauri; Koh, Yun-Joo; Kim, Young Shin; Kauchali, Shuaib; Marcín, Carlos; Montiel-Nava, Cecilia; Patel, Vikram; Paula, Cristiane S; Wang, Chongying; Yasamy, Mohammad Taghi; Fombonne, Eric

2012-01-01

We provide a systematic review of epidemiological surveys of autistic disorder and pervasive developmental disorders (PDDs) worldwide. A secondary aim was to consider the possible impact of geographic, cultural/ethnic, and socioeconomic factors on prevalence estimates and on clinical presentation of PDD. Based on the evidence reviewed, the median of prevalence estimates of autism spectrum disorders was 62/10 000. While existing estimates are variable, the evidence reviewed does not support differences in PDD prevalence by geographic region nor of a strong impact of ethnic/cultural or socioeconomic factors. However, power to detect such effects is seriously limited in existing data sets, particularly in low-income countries. While it is clear that prevalence estimates have increased over time and these vary in different neighboring and distant regions, these findings most likely represent broadening of the diagnostic concets, diagnostic switching from other developmental disabilities to PDD, service availability, and awareness of autistic spectrum disorders in both the lay and professional public. The lack of evidence from the majority of the world's population suggests a critical need for further research and capacity building in low- and middle-income countries. Autism Res 2012, 5: 160–179. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. PMID:22495912

Frequency of use of the International Classification of Diseases ICD-10 diagnostic categories for mental and behavioural disorders across world regions.

PubMed

Faiad, Y; Khoury, B; Daouk, S; Maj, M; Keeley, J; Gureje, O; Reed, G

2017-11-09

The study aimed to examine variations in the use of International Classification of Diseases, Tenth Edition (ICD-10) diagnostic categories for mental and behavioural disorders across countries, regions and income levels using data from the online World Psychiatric Association (WPA)-World Health Organization (WHO) Global Survey that examined the attitudes of psychiatrists towards the classification of mental disorders. A survey was sent to 46 psychiatric societies which are members of WPA. A total of 4887 psychiatrists participated in the survey, which asked about their use of classification, their preferred system and the categories that were used most frequently. The majority (70.1%) of participating psychiatrists (out of 4887 psychiatrists) reported using the ICD-10 the most and using at least one diagnostic category once a week. Nine out of 44 diagnostic categories were considerably variable in terms of frequency of use across countries. These were: emotionally unstable personality disorder, borderline type; dissociative (conversion) disorder; somatoform disorders; obsessive-compulsive disorder (OCD); mental and behavioural disorders due to the use of alcohol; adjustment disorder; mental and behavioural disorders due to the use of cannabinoids; dementia in Alzheimer's disease; and acute and transient psychotic disorder. The frequency of use for these nine categories was examined across WHO regions and income levels. The most striking differences across WHO regions were found for five out of these nine categories. For dissociative (conversion) disorder, use was highest for the WHO Eastern Mediterranean Region (EMRO) and non-existent for the WHO African Region. For mental and behavioural disorders due to the use of alcohol, use was lowest for EMRO. For mental and behavioural disorders due to the use of cannabinoids, use was lowest for the WHO European Region and the WHO Western Pacific Region. For OCD and somatoform disorders, use was lowest for EMRO and the WHO Southeast Asian Region. Differences in the frequency of use across income levels were statistically significant for all categories except for mental and behavioural disorders due to the use of alcohol. The most striking variations were found for acute and transient psychotic disorder, which was reported to be more commonly used among psychiatrists from countries with lower income levels. The differences in frequency of use reported in the current study show that cross-cultural variations in psychiatric practice exist. However, whether these differences are due to the variations in prevalence, treatment-seeking behaviour and other factors, such as psychiatrist and patient characteristics as a result of culture, cannot be determined based on the findings of the study. Further research is needed to examine whether these variations are culturally determined and how that would affect the cross-cultural applicability of ICD-10 diagnostic categories.

Energy Efficiency and Sustainability of Different Building Structures in Latvian Climate

NASA Astrophysics Data System (ADS)

Jakovičs, A.; Gendelis, S.; Bandeniece, L.

2015-11-01

Five experimental test buildings have been built in Riga, Latvia. They are identical except external walls for which different mainly regional building materials are used. Calculated U-values of the other walls, floor and ceiling are the same for each test building. Initial moisture influences the relative humidity of indoor air, which can be higher in the initial time period; as a result, heat transmittances are also very different and cause different heating/cooling energy consumption. Overheating risk in summer exists for test buildings with the smallest thermal inertia. Both summer and heating seasons have been analysed and differences between five test houses have been discussed in details.

Integrated Analysis and Visualization of Group Differences in Structural and Functional Brain Connectivity: Applications in Typical Ageing and Schizophrenia.

PubMed

Langen, Carolyn D; White, Tonya; Ikram, M Arfan; Vernooij, Meike W; Niessen, Wiro J

2015-01-01

Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations of significantly different connections comparing multiple metrics are presented. On the global level, "bi-modal comparison plots" show the distribution of uni- and bi-modal group differences and the relationship between structure and function. Differences between brain lobes are visualized using "worm plots". Group differences in connections are examined with an existing visualization, the "connectogram". These visualizations were evaluated in two proof-of-concept studies: (1) middle-aged versus elderly subjects; and (2) patients with schizophrenia versus controls. Each included two measures derived from diffusion weighted images and two from functional magnetic resonance images. The structural measures were minimum cost path between two anatomical regions according to the "Statistical Analysis of Minimum cost path based Structural Connectivity" method and the average fractional anisotropy along the fiber. The functional measures were Pearson's correlation and partial correlation of mean regional time series. The relationship between structure and function was similar in both studies. Uni-modal group differences varied greatly between connectivity types. Group differences were identified in both studies globally, within brain lobes and between regions. In the aging study, minimum cost path was highly effective in identifying group differences on all levels; fractional anisotropy and mean correlation showed smaller differences on the brain lobe and regional levels. In the schizophrenia study, minimum cost path and fractional anisotropy showed differences on the global level and within brain lobes; mean correlation showed small differences on the lobe level. Only fractional anisotropy and mean correlation showed regional differences. The presented visualizations were helpful in comparing and evaluating connectivity measures on multiple levels in both studies.

UAB UTC transit related activities

DOT National Transportation Integrated Search

2011-01-25

The ITS Strategic Plan outlines a strategy for improving the efficiency of the Region's existing highway and transit systems. The Region's overall goal is to improve the efficiency and effectiveness of existing systems so as to reduce the need to bui...

HLA non-class II genes may confer type I diabetes susceptibility in a Mapuche (Amerindian) affected family.

PubMed

Pérez-Bravo, Francisco; Martinez-Laso, Jorge; Martin-Villa, Jose M; Moscoso, Juan; Moreno, Almudena; Serrano-Vela, Juan I; Zamora, Jorge; Asenjo, Silvia; Gleisner, Andrea; Arnaiz-Villena, Antonio

2006-01-01

A rare case of type I diabetes is studied in an Amerindian (Mapuche) family from Chile, analyzing glutamic acid decarboxylase, islet-cell autoantibodies and human leukocyte antigen (HLA) genes. The affected sib is the only one that has one specific HLA haplotype combination that differs from the other sibs only in the HLA class I genes. It is concluded that HLA diabetes susceptibility factors may be placed outside the class II region or even that susceptibility factors do not exist in the HLA region in this Amerindian family.

Structural and Developmental Disparity in the Tentacles of the Moon Jellyfish Aurelia sp.1

PubMed Central

Gold, David A.; Nakanishi, Nagayasu; Hensley, Nicholai M.; Cozzolino, Kira; Tabatabaee, Mariam; Martin, Michelle; Hartenstein, Volker; Jacobs, David K.

2015-01-01

Tentacles armed with stinging cells (cnidocytes) are a defining trait of the cnidarians, a phylum that includes sea anemones, corals, jellyfish, and hydras. While cnidarian tentacles are generally characterized as structures evolved for feeding and defense, significant variation exists between the tentacles of different species, and within the same species across different life stages and/or body regions. Such diversity suggests cryptic distinctions exist in tentacle function. In this paper, we use confocal and transmission electron microscopy to contrast the structure and development of tentacles in the moon jellyfish, Aurelia species 1. We show that polyp oral tentacles and medusa marginal tentacles display markedly different cellular and muscular architecture, as well as distinct patterns of cellular proliferation during growth. Many structural differences between these tentacle types may reflect biomechanical solutions to different feeding strategies, although further work would be required for a precise mechanistic understanding. However, differences in cell proliferation dynamics suggests that the two tentacle forms lack a conserved mechanism of development, challenging the textbook-notion that cnidarian tentacles can be homologized into a conserved bauplan. PMID:26241309

Structural and Developmental Disparity in the Tentacles of the Moon Jellyfish Aurelia sp.1.

PubMed

Gold, David A; Nakanishi, Nagayasu; Hensley, Nicholai M; Cozzolino, Kira; Tabatabaee, Mariam; Martin, Michelle; Hartenstein, Volker; Jacobs, David K

2015-01-01

Tentacles armed with stinging cells (cnidocytes) are a defining trait of the cnidarians, a phylum that includes sea anemones, corals, jellyfish, and hydras. While cnidarian tentacles are generally characterized as structures evolved for feeding and defense, significant variation exists between the tentacles of different species, and within the same species across different life stages and/or body regions. Such diversity suggests cryptic distinctions exist in tentacle function. In this paper, we use confocal and transmission electron microscopy to contrast the structure and development of tentacles in the moon jellyfish, Aurelia species 1. We show that polyp oral tentacles and medusa marginal tentacles display markedly different cellular and muscular architecture, as well as distinct patterns of cellular proliferation during growth. Many structural differences between these tentacle types may reflect biomechanical solutions to different feeding strategies, although further work would be required for a precise mechanistic understanding. However, differences in cell proliferation dynamics suggests that the two tentacle forms lack a conserved mechanism of development, challenging the textbook-notion that cnidarian tentacles can be homologized into a conserved bauplan.

The Lake Towuti Drilling Project: A New, 1-Million Year Record of Indo-Pacific Hydroclimate

NASA Astrophysics Data System (ADS)

Russell, J. M.; Bijaksana, S.; Vogel, H.; Melles, M.; Crowe, S.; Fajar, S. J.; Hasberg, A. K.; Ivory, S.; Kallmeyer, J.; Kelly, C. S.; Kirana, K. H.; Morlock, M.; Tamuntuan, G. H.; Wicaksono, S. A.

2015-12-01

­The Indo-Pacific region plays an integral role in the Earth's climate system. Changes in local insolation, greenhouse gas concentrations, ice volume, and local sea level are each hypothesized to exert a dominant control on Indo-Pacific hydroclimate variations through the Pleistocene, yet existing records from the region are generally short and exhibit fundamental differences in orbital-scale patterns that limit our understanding of the regional climate responses to these global forcings. New paleoclimate records spanning multiple glacial-interglacial cycles are therefore required to document the region's hydroclimatic response to the full range of global climate boundary conditions observed during the late Quaternary. Lake Towuti is located in central Indonesia and is the only known terrestrial sedimentary archive in the region that spans multiple glacial-interglacial cycles. From May - July, 2015, the Towuti Drilling Project, consisting of nearly 40 scientists from eight countries, recovered over 1,000 meters of new sediment core from Lake Towuti. This includes cores though the entire sediment column to bedrock, which likely provide a >1-million-year records of regional hydroclimate. On-site borehole and sediment core logging data document major shifts in sediment composition, including transitions from lake clays to peats, calcareous sediments, and gravels. These data show excellent agreement with major lithological transitions recorded in seismic reflection data, and indicate large changes in lake levels and hydroclimate through the late Quaternary. Prior work on Lake Towuti indicated a dominant control by global ice volume on regional hydroclimate, a hypothesis we aim to test through the analysis of these new cores. This presentation will review existing records from the region and show the first long geochemical and sedimentological records from Lake Towuti to understand orbital-scale hydrologic change during the last ~1 million years.

Progressive age-dependence and frequency difference in the effect of gap junctions on active cochlear amplification and hearing.

PubMed

Zong, Liang; Chen, Jin; Zhu, Yan; Zhao, Hong-Bo

2017-07-22

Mutations of Connexin 26 (Cx26, GJB2), which is a predominant gap junction isoform in the cochlea, can induce high incidence of nonsyndromic hearing loss. We previously found that targeted-deletion of Cx26 in supporting Deiters cells and outer pillar cells in the cochlea can influence outer hair cell (OHC) electromotility and reduce active cochlear amplification leading to hearing loss, even though there are no gap junction connexin expressions in the auditory sensory hair cells. Here, we further report that hearing loss and the reduction of active amplification in the Cx26 targeted-deletion mice are progressive and different at high and low frequency regions, first occurring in the high frequency region and then progressively extending to the middle and low frequency regions with mouse age increased. The speed of hearing loss extending was fast in the basal high frequency region and slow in the apical low frequency region, showing a logarithmic function with mouse age. Before postnatal day 25, there were no significant hearing loss and the reduction of active cochlear amplification in the low frequency region. Hearing loss and the reduction of active cochlear amplification also had frequency difference, severe and large in the high frequency regions. These new data indicate that the effect of gap junction on active cochlear amplification is progressive, but, consistent with our previous report, exists in both high and low frequency regions in adulthood. These new data also suggest that cochlear gap junctions may have an important role in age-related hearing loss. Copyright © 2017 Elsevier Inc. All rights reserved.

Neurologic injuries in boxing and other combat sports.

PubMed

Zazryn, Tsharni R; McCrory, Paul R; Cameron, Peter A

2009-02-01

Many sports have neurologic injury from incidental head contact; however, combat sports allow head contact, and a potential exists for acute and chronic neurologic injuries. Although each combat sport differs in which regions of the body can be used for contact, they are similar in competitor exposure time. Their acute injury rates are similar; thus their injuries can appropriately be considered together. Injuries of all types occur in combat sports, with injuries in between one fifth to one half of all fights in boxing, karate, and tae kwon do. Most boxing injuries are to the head and neck region. In other combat sports, the head and neck region are the second (after the lower limbs) or the first most common injury site.

Neurologic injuries in boxing and other combat sports.

PubMed

Zazryn, Tsharni R; McCrory, Paul R; Cameron, Peter A

2008-02-01

Many sports have neurologic injury from incidental head contact; however, combat sports allow head contact, and a potential exists for acute and chronic neurologic injuries. Although each combat sport differs in which regions of the body can be used for contact, they are similar in competitor exposure time. Their acute injury rates are similar; thus their injuries can appropriately be considered together. Injuries of all types occur in combat sports, with injuries in between one fifth to one half of all fights in boxing, karate, and tae kwon do. Most boxing injuries are to the head and neck region. In other combat sports, the head and neck region are the second (after the lower limbs) or the first most common injury site.

Viscoplasticity based on overstress with a differential growth law for the equilibrium stress

NASA Technical Reports Server (NTRS)

Krempl, E.; Mcmahon, J. J.; Yao, D.

1985-01-01

Two coupled, nonlinear differential equations are proposed for the modeling of the elastic and rate (time) dependent inelastic behavior of structural metals in the absence of recovery and aging. The structure of the model is close to the unified theories but contains essential differences. It is shown that the model reproduces almost elastic regions upon initial loading and in the unloading regions of the hysteresis loop. Under loading, unloading and reloading in strain control the model simulated the experimentally observed sharp transition from nearly elastic to inelastic behavior. When a formulation akin to existing unified theories is adopted the almost elastic regions reduce the points and the transition upon reloading is very gradual. For different formulations the behavior under sudden in(de)creases of the strain rate by two orders of magnitude is simulated by numerical experiments and differences are noted. The model represents cyclically neutral behavior and contains three constants and two positive, decreasing functions. The determination of constants and functions from monotonic loading with strain rate changes and relaxation periods is described.

Functional connectivity in the mouse brain imaged by B-mode photoacoustic microscopy

NASA Astrophysics Data System (ADS)

Nasiriavanaki, Mohammadreza; Xing, Wenxin; Xia, Jun; Wang, Lihong V.

2014-03-01

The increasing use of mouse models for human brain disease studies, coupled with the fact that existing functional imaging modalities cannot be easily applied to mice, presents an emerging need for a new functional imaging modality. Utilizing acoustic-resolution photoacoustic microscopy (AR-PAM), we imaged spontaneous cerebral hemodynamic fluctuations and their associated functional connections in the mouse brain. The images were acquired noninvasively in B-scan mode with a fast frame rate, a large field of view, and a high spatial resolution. At a location relative to the bregma 0, correlations were investigated inter-hemispherically between bilaterally homologous regions, as well as intra-hemispherically within the same functional regions. The functional connectivity in different functional regions was studied. The locations of these regions agreed well with the Paxinos mouse brain atlas. The functional connectivity map obtained in this study can then be used in the investigation of brain disorders such as stroke, Alzheimer's, schizophrenia, multiple sclerosis, autism, and epilepsy. Our experiments show that photoacoustic microscopy is capable to detect connectivities between different functional regions in B-scan mode, promising a powerful functional imaging modality for future brain research.

Special Issues Related to Hematopoietic Stem Cell Transplantation in the Eastern Mediterranean Region and the First Regional Activity Report

PubMed Central

Aljurf, Mahmoud; Zaidi, Syed Z; El Solh, Hassan; Hussain, Fazal; Ghavamzadeh, Ardeshir; Mahmoud, Hossam Kamel; Shamsi, Tahir; Othman, Tarek Ben; Sarhan, Mahmoud M.; Dennison, David; Ibrahim, Ahmad; Benchekroun, Said; Chaudhri, Naeem; Labar, Boris; Horowitz, Mary; Niederwieser, Dietger; Gratwohl, Alois

2012-01-01

Although several centers are now performing allogeneic HSCT in the Eastern Mediterranean (EM) region, the availability is still limited. Special issues including compatible donor availability and potential for alternate donor programs are discussed. In comparison to Europe & North America, differences in pattern of diseases and pre-HSCT general status particularly for patients with BM failure are described. Other differences including high seropositivity for CMV, Hepatitis B and C infection and specific observations about GVHD with its relation to genetically homogeneous community are also discussed. We report that a total of 17 HSCT programs (performing 5 or more HSCTs annually) exist in 9 countries of the EM region. Only 6 programs are currently reporting to EBMT or IBMTR. A total of 7617 HSCTs have been performed by these programs including 5701 allogeneic HSCTs. Due to low HSCT team density (1.5583 teams/10 million inhabitants vs. 14.4333 in Europe) and very low HSCT team distribution (0.2729 teams/10,000 sq km area vs. <1 to 6 teams in Europe). GNI/capita had no clear association with low HSCT activity; however improvement in infrastructure & formation of EM regional HSCT registry are needed. PMID:19043456

Bulge Region as a Putative Hair Follicle Stem Cells Niche: A Brief Review

PubMed Central

JOULAI VEIJOUYE, Sanaz; YARI, Abazar; HEIDARI, Fatemeh; SAJEDI, Nayereh; GHOROGHI MOGHANI, Fatemeh; NOBAKHT, Maliheh

2017-01-01

Background: Hair follicle stem cells exist in different sites. Most of the hair follicle stem cells are reside in niche called bulge. Bulge region is located between the opening of sebaceous gland and the attachment site of the arrector pili muscle. Methods: Data were collected using databases and resources of PubMed, Web of Science, Science Direct, Scopus, MEDLINE and their references from the earliest available published to identify English observational studies on hair follicle bulge region. Results: Bulge stem cells are pluripotent with high proliferative capacity. Specific markers allow the bulge cells to be isolated from mouse or human hair follicle. Stem cells isolated from bulge region are label retaining and slow cycling hence these cells are defined as label-retaining cells. Bulge cell populations, due to their plasticity nature are able to differentiate into distinct linage and could contribute in tissue regeneration. Conclusion: The current review discuss about bulge stem cells characteristics and biology including their cycle, location, plasticity, specific markers and regenerative nature. Also the differences between mouse and human hair follicles are investigated. PMID:29026781

Spinocerebellar ataxia in monozygotic twins.

PubMed

Anderson, John H; Christova, Peka S; Xie, Ting-dong; Schott, Kelly S; Ward, Kenneth; Gomez, Christopher M

2002-12-01

Although phenotypic heterogeneity in autosomal dominant spinocerebellar ataxia (SCA) has been explained in part by genotypic heterogeneity, clinical observations suggest the influence of additional factors. To demonstrate, quantitate, and localize physiologic abnormalities attributable to nongenetic factors in the development of hereditary SCA. Quantitative assessments of ocular motor function and postural control in 2 sets of identical twins, one with SCA type 2 and the other with episodic ataxia type 2. University laboratory. Saccadic velocity and amplitude, pursuit gain, and dynamic posturography. We found significant differences in saccade velocity, saccade metrics, and postural stability between each monozygotic twin. The differences point to differential involvement between twins of discrete regions in the cerebellum and brainstem. These results demonstrate the presence of quantitative differences in the severity, rate of progression, and regional central nervous system involvement in monozygotic twins with SCA that must be owing to the existence of nongermline or external factors.

Analysis of differences between Western and East-Asian faces based on facial region segmentation and PCA for facial expression recognition

NASA Astrophysics Data System (ADS)

Benitez-Garcia, Gibran; Nakamura, Tomoaki; Kaneko, Masahide

2017-01-01

Darwin was the first one to assert that facial expressions are innate and universal, which are recognized across all cultures. However, recent some cross-cultural studies have questioned this assumed universality. Therefore, this paper presents an analysis of the differences between Western and East-Asian faces of the six basic expressions (anger, disgust, fear, happiness, sadness and surprise) focused on three individual facial regions of eyes-eyebrows, nose and mouth. The analysis is conducted by applying PCA for two feature extraction methods: appearance-based by using the pixel intensities of facial parts, and geometric-based by handling 125 feature points from the face. Both methods are evaluated using 4 standard databases for both racial groups and the results are compared with a cross-cultural human study applied to 20 participants. Our analysis reveals that differences between Westerns and East-Asians exist mainly on the regions of eyes-eyebrows and mouth for expressions of fear and disgust respectively. This work presents important findings for a better design of automatic facial expression recognition systems based on the difference between two racial groups.

Heat accumulation period in the Mediterranean region: phenological response of the olive in different climate areas (Spain, Italy and Tunisia).

PubMed

Aguilera, Fátima; Ruiz, Luis; Fornaciari, Marco; Romano, Bruno; Galán, Carmen; Oteros, Jose; Ben Dhiab, Ali; Msallem, Monji; Orlandi, Fabio

2014-07-01

The main characteristics of the heat accumulation period and the possible existence of different types of biological response to the environment in different populations of olive through the Mediterranean region have been evaluated. Chilling curves to determine the start date of the heat accumulation period were constructed and evaluated. The results allow us to conclude that the northern olive populations have the greatest heat requirements for the development of their floral buds, and they need a period of time longer than olives in others areas to completely satisfy their biothermic requirements. The olive trees located in the warmest winter areas have a faster transition from endogenous to exogenous inhibition once the peak of chilling is met, and they show more rapid floral development. The lower heat requirements are due to better adaptation to warmer regions. Both the threshold temperature and the peak of flowering date are closely related to latitude. Different types of biological responses of olives to the environment were found. The adaptive capacity shown by the olive tree should be considered as a useful tool with which to study the effects of global climatic change on agro-ecosystems.

Intraspecific variation in Cryptocaryon irritans.

PubMed

Diggles, B K; Adlard, R D

1997-01-01

Intraspecific variation in the ciliate Cryptocaryon irritans was examined using sequences of the first internal transcribed spacer region (ITS-1) of ribosomal DNA (rDNA) combined with developmental and morphological characters. Amplified rDNA sequences consisting of 151 bases of the flanking 18 S and 5.8 S regions, and the entire ITS-1 region (169 or 170 bases), were determined and compared for 16 isolates of C. irritans from Australia, Israel and the USA. There was one variable base between isolates in the 18 S region and 11 variable bases in the ITS-1 region. Despite their similar morphology, significant sequence variation (4.1% divergence) and developmental differences indicate that Australian C. irritans isolates from estuarine (Moreton Bay) and coral reef (Heron Island) environments are distinct. The Heron Island isolate was genetically closer to morphologically dissimilar isolates from Israel (1.8% divergence) and the USA (2.3% divergence) than it was to the Moreton Bay isolates. Three isolates maintained in our laboratory since February 1994 differed in sequence from earlier laboratory isolates (2.9% to 3.5% divergence), even though all were similar morphologically and originated from the same source. During this time the sequence of the isolates from wild fish in Moreton Bay remained unchanged. These genetic differences indicate the existence of a founder effect in laboratory populations of C. irritans. The genetic variation found here, combined with known morphological and developmental differences, is used to characterise four strains of C. irritans.

Conceptual Regional Sediment Budget for USACE North Atlantic Division

DTIC Science & Technology

2015-03-01

sediment budget is the first phase in development of the working budget and is intended to provide a general framework based on existing transport ...existing literature and databases were reviewed and analyzed to characterize sediment transport pathways and magnitudes, and morphologic zones of...net sediment transport pathways for Region 1 (includes NACCS planning regions VA1 through VA6 and MD2 through MD5

Regional Climate Simulation and Data Assimilation with Variable-Resolution GCMs

NASA Technical Reports Server (NTRS)

Fox-Rabinovitz, Michael S.

2002-01-01

Variable resolution GCMs using a global stretched grid (SG) with enhanced regional resolution over one or multiple areas of interest represents a viable new approach to regional climateklimate change and data assimilation studies and applications. The multiple areas of interest, at least one within each global quadrant, include the major global mountains and major global monsoonal circulations over North America, South America, India-China, and Australia. They also can include the polar domains, and the European and African regions. The SG-approach provides an efficient regional downscaling to mesoscales, and it is an ideal tool for representing consistent interactions of globaYlarge- and regionallmeso- scales while preserving the high quality of global circulation. Basically, the SG-GCM simulations are no different from those of the traditional uniform-grid GCM simulations besides using a variable-resolution grid. Several existing SG-GCMs developed by major centers and groups are briefly described. The major discussion is based on the GEOS (Goddard Earth Observing System) SG-GCM regional climate simulations.

A review on natural background radiation

PubMed Central

Shahbazi-Gahrouei, Daryoush; Gholami, Mehrdad; Setayandeh, Samaneh

2013-01-01

The world is naturally radioactive and approximately 82% of human-absorbed radiation doses, which are out of control, arise from natural sources such as cosmic, terrestrial, and exposure from inhalation or intake radiation sources. In recent years, several international studies have been carried out, which have reported different values regarding the effect of background radiation on human health. Gamma radiation emitted from natural sources (background radiation) is largely due to primordial radionuclides, mainly 232Th and 238U series, and their decay products, as well as 40K, which exist at trace levels in the earth's crust. Their concentrations in soil, sands, and rocks depend on the local geology of each region in the world. Naturally occurring radioactive materials generally contain terrestrial-origin radionuclides, left over since the creation of the earth. In addition, the existence of some springs and quarries increases the dose rate of background radiation in some regions that are known as high level background radiation regions. The type of building materials used in houses can also affect the dose rate of background radiations. The present review article was carried out to consider all of the natural radiations, including cosmic, terrestrial, and food radiation. PMID:24223380

Rapid Detection of Positive Selection in Genes and Genomes Through Variation Clusters

PubMed Central

Wagner, Andreas

2007-01-01

Positive selection in genes and genomes can point to the evolutionary basis for differences among species and among races within a species. The detection of positive selection can also help identify functionally important protein regions and thus guide protein engineering. Many existing tests for positive selection are excessively conservative, vulnerable to artifacts caused by demographic population history, or computationally very intensive. I here propose a simple and rapid test that is complementary to existing tests and that overcomes some of these problems. It relies on the null hypothesis that neutrally evolving DNA regions should show a Poisson distribution of nucleotide substitutions. The test detects significant deviations from this expectation in the form of variation clusters, highly localized groups of amino acid changes in a coding region. In applying this test to several thousand human–chimpanzee gene orthologs, I show that such variation clusters are not generally caused by relaxed selection. They occur in well-defined domains of a protein's tertiary structure and show a large excess of amino acid replacement over silent substitutions. I also identify multiple new human–chimpanzee orthologs subject to positive selection, among them genes that are involved in reproductive functions, immune defense, and the nervous system. PMID:17603100

Vortex Analysis of Intra-Aneurismal Flow in Cerebral Aneurysms

PubMed Central

Sunderland, Kevin; Haferman, Christopher; Chintalapani, Gouthami

2016-01-01

This study aims to develop an alternative vortex analysis method by measuring structure ofIntracranial aneurysm (IA) flow vortexes across the cardiac cycle, to quantify temporal stability of aneurismal flow. Hemodynamics were modeled in “patient-specific” geometries, using computational fluid dynamics (CFD) simulations. Modified versions of known λ 2 and Q-criterion methods identified vortex regions; then regions were segmented out using the classical marching cube algorithm. Temporal stability was measured by the degree of vortex overlap (DVO) at each step of a cardiac cycle against a cycle-averaged vortex and by the change in number of cores over the cycle. No statistical differences exist in DVO or number of vortex cores between 5 terminal IAs and 5 sidewall IAs. No strong correlation exists between vortex core characteristics and geometric or hemodynamic characteristics of IAs. Statistical independence suggests this proposed method may provide novel IA information. However, threshold values used to determine the vortex core regions and resolution of velocity data influenced analysis outcomes and have to be addressed in future studies. In conclusions, preliminary results show that the proposed methodology may help give novel insight toward aneurismal flow characteristic and help in future risk assessment given more developments. PMID:27891172

Vortex Analysis of Intra-Aneurismal Flow in Cerebral Aneurysms.

PubMed

Sunderland, Kevin; Haferman, Christopher; Chintalapani, Gouthami; Jiang, Jingfeng

2016-01-01

This study aims to develop an alternative vortex analysis method by measuring structure ofIntracranial aneurysm (IA) flow vortexes across the cardiac cycle, to quantify temporal stability of aneurismal flow. Hemodynamics were modeled in "patient-specific" geometries, using computational fluid dynamics (CFD) simulations. Modified versions of known λ 2 and Q -criterion methods identified vortex regions; then regions were segmented out using the classical marching cube algorithm. Temporal stability was measured by the degree of vortex overlap (DVO) at each step of a cardiac cycle against a cycle-averaged vortex and by the change in number of cores over the cycle. No statistical differences exist in DVO or number of vortex cores between 5 terminal IAs and 5 sidewall IAs. No strong correlation exists between vortex core characteristics and geometric or hemodynamic characteristics of IAs. Statistical independence suggests this proposed method may provide novel IA information. However, threshold values used to determine the vortex core regions and resolution of velocity data influenced analysis outcomes and have to be addressed in future studies. In conclusions, preliminary results show that the proposed methodology may help give novel insight toward aneurismal flow characteristic and help in future risk assessment given more developments.

Toward an operational framework for fine-scale urban land-cover mapping in Wallonia using submeter remote sensing and ancillary vector data

NASA Astrophysics Data System (ADS)

Beaumont, Benjamin; Grippa, Tais; Lennert, Moritz; Vanhuysse, Sabine; Stephenne, Nathalie; Wolff, Eléonore

2017-07-01

Encouraged by the EU INSPIRE directive requirements and recommendations, the Walloon authorities, similar to other EU regional or national authorities, want to develop operational land-cover (LC) and land-use (LU) mapping methods using existing geodata. Urban planners and environmental monitoring stakeholders of Wallonia have to rely on outdated, mixed, and incomplete LC and LU information. The current reference map is 10-years old. The two object-based classification methods, i.e., a rule- and a classifier-based method, for detailed regional urban LC mapping are compared. The added value of using the different existing geospatial datasets in the process is assessed. This includes the comparison between satellite and aerial optical data in terms of mapping accuracies, visual quality of the map, costs, processing, data availability, and property rights. The combination of spectral, tridimensional, and vector data provides accuracy values close to 0.90 for mapping the LC into nine categories with a minimum mapping unit of 15 m2. Such a detailed LC map offers opportunities for fine-scale environmental and spatial planning activities. Still, the regional application poses challenges regarding automation, big data handling, and processing time, which are discussed.

An experimental study of pain upon stimulation of the nasal and sinus cavities.

PubMed

Clerico, Dean M

2014-01-01

To map different areas of pain sensitivity and to determine the existence and/or pattern of referred pain from upon stimulating the sinonasal cavity. Experimental human study. Mechanical and electrical stimulations to various anatomical structures and areas of the nasal and sinus cavities were conducted on nine volunteers. Intensity, location and character of pain were recorded in all subjects. The postero-superior (cephalic) aspect of the nasal cavity, primarily the anterior face of the sphenoid sinus and the superior turbinate, were the most sensitive sites, and the antero-inferior (caudal) region was the least sensitive. Referred pain to the head and face was reported by several subjects. Topographical differences in pain sensitivity exist in the sinonasal cavity. The phenomenon of referred pain from the nasal cavity was demonstrated. Copyright © 2014 Elsevier Inc. All rights reserved.

The coat protein of prunus necrotic ringspot virus specifically binds to and regulates the conformation of its genomic RNA.

PubMed

Aparicio, Frederic; Vilar, Marçal; Perez-Payá, Enrique; Pallás, Vicente

2003-08-15

Binding of coat protein (CP) to the 3' nontranslated region (3'-NTR) of viral RNAs is a crucial requirement to establish the infection of Alfamo- and Ilarviruses. In vitro binding properties of the Prunus necrotic ringspot ilarvirus (PNRSV) CP to the 3'-NTR of its genomic RNA using purified E. coli- expressed CP and different synthetic peptides corresponding to a 26-residue sequence near the N-terminus were investigated by electrophoretic mobility shift assays. PNRSV CP bound to, at least, three different sites existing on the 3'-NTR. Moreover, the N-terminal region between amino acid residues 25 to 50 of the protein could function as an independent RNA-binding domain. Single exchange of some arginine residues by alanine eliminated the RNA-interaction capacity of the synthetic peptides, consistent with a crucial role for Arg residues common to many RNA-binding proteins possessing Arg-rich domains. Circular dichroism spectroscopy revealed that the RNA conformation is altered when amino-terminal CP peptides bind to the viral RNA. Finally, mutational analysis of the 3'-NTR suggested the presence of a pseudoknotted structure at this region on the PNRSV RNA that, when stabilized by the presence of Mg(2+), lost its capability to bind the coat protein. The existence of two mutually exclusive conformations for the 3'-NTR of PNRSV strongly suggests a similar regulatory mechanism at the 3'-NTR level in Alfamo- and Ilarvirus genera.

Unmet Primary Physicians' Needs for Allergic Rhinitis Care in Korea.

PubMed

Yang, Hyeon Jong; Kim, Young Hyo; Lee, Bora; Kong, Do Youn; Kim, Dong Kyu; Kim, Mi Ae; Kim, Bong Seong; Kim, Won Young; Kim, Jeong Hee; Park, Yang; Park, So Yeon; Bae, Woo Yong; Song, Keejae; Yang, Min Suk; Lee, Sang Min; Lee, Young Mok; Lee, Hyun Jong; Cho, Jae Hong; Jee, Hye Mi; Choi, Jeong Hee; Yoo, Young; Koh, Young Il

2017-05-01

Allergic rhinitis (AR) is one of the most common chronic allergic respiratory diseases worldwide. Various practical guidelines for AR have been developed and updated to improve the care of AR patients; however, up to 40% patients remain symptomatic. The unmet need for AR care is one of the greatest public health problems in the world. The gaps between guideline and real-world practice, and differences according to the region, culture, and medical environments may be the causes of unmet needs for AR care. Because there is no evidence-based AR practical guideline reflecting the Korean particularity, various needs are increasing. The purpose of the study was to evaluate whether existing guidelines are sufficient for AR patient management in real practice and whether development of regional guidelines to reflect regional differences is needed in Korea. A total of 99 primary physicians comprising internists, pediatricians, and otolaryngologists (n=33 for each) were surveyed by a questionnaire relating to unmet needs for AR care between June 2 and June 16 of 2014. Among 39 question items, participants strongly agreed on 15 items that existing guidelines were highly insufficient and needed new guidelines. However, there was some disagreement according to specialties for another 24 items. In conclusion, the survey results demonstrated that many physicians did not agree with the current AR guideline, and a new guideline reflecting Korean particularity was needed. Copyright © 2017 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.

Regional Differences in Tear Film Stability and Meibomian Glands in Patients With Aqueous-Deficient Dry Eye.

PubMed

Koh, Shizuka; Ikeda, Chikako; Fujimoto, Hisataka; Oie, Yoshinori; Soma, Takeshi; Maeda, Naoyuki; Nishida, Kohji

2016-07-01

To noninvasively investigate regional differences in tear film stability and meibomian glands in patients with aqueous-deficient dry eye. Forty-nine dry eyes and 31 normal eyes were analyzed. A corneal topographer with a tear film scanning function was used for noninvasive tear film break-up time (NI-TFBUT) measurements and meibomian gland observations. The NI-TFBUT values and location of the first tear film break-up point were recorded in four quadrants. Meibomian gland loss was graded for each eyelid using meiboscores. Lid margin abnormality was scored from zero to four according to the number of existing abnormalities. The NI-TFBUT values and meiboscores were compared between two groups, and regional differences in NI-TFBUT values and meiboscores were analyzed. Also, the correlation between the NI-TFBUT and ocular surface examination results were investigated. The NI-TFBUT values and meiboscores were significantly lower and higher, respectively, for the dry eye group than for the normal group. In the dry eye group, the occurrence rate for first tear film break-up was the highest in the inferior nasal quadrant, and the mean meiboscore was significantly higher for the upper eyelids than for the lower eyelids. The NI-TFBUT and lid margin abnormality scores showed a weak negative correlation, and the NI-TFBUT values and meiboscores showed no correlation. Compared to normal eyes, aqueous-deficient dry eyes show significant regional differences in tear film stability and meibomian glands. Considering these regional differences, the overall observation of the ocular surface, including both upper and lower eyelids, will aid clinicians in understanding this condition better.

Population structure and relatedness among female Northern Pintails in three California wintering regions

USGS Publications Warehouse

Fleskes, Joseph P.; Fowler, Ada C.; Casazza, Michael L.; Eadie, John M.

2010-01-01

Female Northern Pintails (Anas acuta) were sampled in California's three main Central Valley wintering regions (Sacramento Valley, Suisun Marsh, San Joaquin Valley) during September–October before most regional movements occur and microsatellite and mitochondrial DNA were analyzed to examine population structure and relatedness. Despite reportedly high rates of early-fall pairing and regional fidelity, both sets of markers indicated that there was little overall genetic structuring by region. Pintails from Suisun Marsh did exhibit higher relatedness among individuals and capture groups than in the Sacramento or San Joaquin Valleys, likely reflecting a sample comprised of a greater proportion of local breeders. The lack of genetic structuring among regions indicates that a high degree of movement and interchange occurs among pintails wintering in the Central Valley. Thus, although maintaining the existing distribution of pintails among Central Valley regions is important for other reasons, it does not appear to be critical to retain current patterns of population genetic variation. Because of potential lack of independence among highly related study individuals, researchers should consider regional differences in relatedness when designing sampling schemes and interpreting research findings.

Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with low-frequency ultrasound and sodium lauryl sulfate.

PubMed

Kushner, Joseph; Blankschtein, Daniel; Langer, Robert

2008-02-01

The porosity (epsilon), the tortuosity (tau), and the hindrance factor (H) of the aqueous pore channels located in the localized transport regions (LTRs) and the non-LTRs formed in skin treated simultaneously with low-frequency ultrasound (US) and the surfactant sodium lauryl sulfate (SLS), were evaluated for the delivery of four hydrophilic permeants (urea, mannitol, raffinose, and inulin) by analyzing dual-radiolabeled diffusion masking experiments for three different idealized cases of the aqueous pore pathway hypothesis. When epsilon and tau were assumed to be independent of the permeant radius, H was found to be statistically larger in the LTRs than in the non-LTRs. When a distribution of pore radii was assumed to exist in the skin, no statistical differences in epsilon, tau, and H were observed due to the large variation in the pore radii distribution shape parameter (3 A to infinity). When infinitely large aqueous pores were assumed to exist in the skin, epsilon was found to be 3-8-fold greater in the LTRs than in the non-LTRs, while little difference was observed in the LTRs and in the non-LTRs for tau. This last result suggests that the efficacy of US/SLS treatment may be enhanced by increasing the porosity of the non-LTRs.

ENSURF: multi-model sea level forecast - implementation and validation results for the IBIROOS and Western Mediterranean regions

NASA Astrophysics Data System (ADS)

Pérez, B.; Brower, R.; Beckers, J.; Paradis, D.; Balseiro, C.; Lyons, K.; Cure, M.; Sotillo, M. G.; Hacket, B.; Verlaan, M.; Alvarez Fanjul, E.

2011-04-01

ENSURF (Ensemble SURge Forecast) is a multi-model application for sea level forecast that makes use of existing storm surge or circulation models today operational in Europe, as well as near-real time tide gauge data in the region, with the following main goals: - providing an easy access to existing forecasts, as well as to its performance and model validation, by means of an adequate visualization tool - generation of better forecasts of sea level, including confidence intervals, by means of the Bayesian Model Average Technique (BMA) The system was developed and implemented within ECOOP (C.No. 036355) European Project for the NOOS and the IBIROOS regions, based on MATROOS visualization tool developed by Deltares. Both systems are today operational at Deltares and Puertos del Estado respectively. The Bayesian Modelling Average technique generates an overall forecast probability density function (PDF) by making a weighted average of the individual forecasts PDF's; the weights represent the probability that a model will give the correct forecast PDF and are determined and updated operationally based on the performance of the models during a recent training period. This implies the technique needs the availability of sea level data from tide gauges in near-real time. Results of validation of the different models and BMA implementation for the main harbours will be presented for the IBIROOS and Western Mediterranean regions, where this kind of activity is performed for the first time. The work has proved to be useful to detect problems in some of the circulation models not previously well calibrated with sea level data, to identify the differences on baroclinic and barotropic models for sea level applications and to confirm the general improvement of the BMA forecasts.

Patterns of Genetic Diversity and Co-Existence in Open Ocean Diatoms: the Effects of Water Mass Structure, Selection and Sex

NASA Astrophysics Data System (ADS)

Rynearson, T. A.; Chen, G.

2016-02-01

The open ocean North Atlantic spring bloom influences regional ecology and global biogeochemistry. Diatoms dominate the peak of the bloom and significantly impact productivity and export of organic carbon from the bloom. Despite their key role in a yearly event with global impacts, the genetic diversity and population structure of diatoms that comprise this open ocean bloom are unknown. Here we investigated the population genetics of the diatom Thalassiosira gravida sampled during the 2008 North Atlantic Bloom Experiment using newly-developed microsatellite markers. Here, we show that the genetic diversity of open ocean diatoms is high and that their population structure differs dramatically from coastal diatoms. High levels of genetic diversity were observed across all water samples and did not change during the bloom. Four genetically distinct populations were identified but were not associated with different water masses, depths or time points during the bloom. Instead, all four populations co-existed within samples, spanning different water masses, stages of the bloom and depths of over >300 m. The pattern of genetically distinct, co-existing populations in the open ocean contrasts dramatically with coastal habitats, where distinct populations have not been observed to co-exist at the same time and place. It is likely that populations originate via transport from disparate locations combined with overwintering capacity in the water column or sediments. The pattern of co-existence suggests that the open ocean may serve as a gene pool that harbors different populations that are then available for selection to act upon, which may contribute to the ecological and biogeochemical success of diatoms and influence their long-term evolutionary survival.

Thermal shielding of an emerging active region

NASA Astrophysics Data System (ADS)

Régnier, S.

2012-08-01

Context. The interaction between emerging active regions and the pre-existing coronal magnetic field is important for better understanding the mechanisms of storage and release of magnetic energy from the convection zone to the high corona. Aims: We describe the first steps of an emerging active region within a pre-existing quiet-Sun corona in terms of the thermal and magnetic structure. Methods: We used unprecedented spatial, temporal and spectral coverage from the Atmospheric Imager Assembly (AIA) and from the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory (SDO). Results: Starting on 30 May 2010 at 17:00 UT, we followed the emerging active region AR11076 within a quiet-Sun region for 8 h. Using several SDO/AIA filters that cover temperatures from 50 000 K to 10 MK, we show that the emerging process is characterised by a thermal shield at the interface between the emerging flux and pre-existing quiet-Sun corona. Conclusions: The active region 11076 is a peculiar example of an emerging active region because (i) the polarities emerge in a photospheric quiet-Sun region near a supergranular-like distribution, and (ii) the polarities that form the bipolar emerging structure do not rotate with respect to each other, which indicates a slight twist in the emerging flux bundle. There is a thermal shield at the interface between the emerging active region and the pre-existing quiet-Sun region. The thermal shielding structure deduced from all SDO/AIA channels is strongly asymmetric between the two polarities of the active region, suggesting that the heating mechanism for one polarity is probably magnetic reconnection, whilst it is caused by increasing magnetic pressure for the opposite polarity. Appendix A and two movies are available in electronic form at http://www.aanda.org

Relevance of the Sustainable Rangelands Roundtable Criteria and Indicators for Sustainable Rangeland Management to Conditions in Patagonia (Argentina)

Treesearch

Andrés F. Cibils; Gabriel E. Oliva

2006-01-01

Patagonia’s rangelands are similar to those in western United States in terms of climate, topography, and vegetation physiognomy. However, differences in environmental, economic, and societal values do exist between regions. We assessed the usefulness of C&I (Criteria and Indicators) developed in the United States for other countries, and identified indicators not...

Two Stochastic Phases of Tick-wise Price Fluctuation and the Price Prediction Generator

NASA Astrophysics Data System (ADS)

Tanaka-Yamawaki, Mieko; Tokuoka, Seiji

2007-07-01

We report in this paper the existence of two different stochastic phases in the tick-wise price fluctuations. Based on this observation, we improve our old method of developing the evolutional strategy to predict the direction of the tick-wise price movements. We obtain a stable predictive power even in the region where the old method had a difficulty.

Middle School A/B Block and Traditional Scheduling: An Analysis of Math and Reading Performance by Race

ERIC Educational Resources Information Center

Gill, Willie Wallicia Allen

2011-01-01

The purpose of this quantitative study was to examine whether a difference existed in the percentage performance of students earning a pass/advanced score on the Standards of Learning (SOL) Test in math and reading in Virginia's Region IV for schools using an A/B block schedule and those using a traditional schedule. The research also examined if…

[Emergencies and urgent consultation in non-urban Swiss general practices].

PubMed

Meyer, R L; Marty, F

2007-03-07

The upcoming shortage of general practitioners in Switzerland will be a big challenge for medical out-of-hours services. Regionally ver different exists only few datas about organisational matters of and problems seen in "out-of-hours" care and "urgent consultations". Our Pilot present the prevalence of "out-of-hours care" in a general practitioner setting describes and classifies the problems seen using ICPC-2.

Neurology Training Worldwide.

PubMed

Hillis, James M; Berkowitz, Aaron L

2018-04-01

Neurology training is essential for providing neurologic care globally. Large disparities in availability of neurology training exist between higher- and lower-income countries. This review explores the worldwide distribution of neurology training programs and trainees, the characteristics of training programs in different parts of the world, and initiatives aimed at increasing access to neurology training in under-resourced regions. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Country-specific dietary patterns and associations with socioeconomic status in European children: the IDEFICS study.

PubMed

Fernández-Alvira, J M; Bammann, K; Pala, V; Krogh, V; Barba, G; Eiben, G; Hebestreit, A; Veidebaum, T; Reisch, L; Tornaritis, M; Kovacs, E; Huybrechts, I; Moreno, L A

2014-07-01

Children from lower socioeconomic status (SES) may be at higher risk of unhealthy eating. We described country-specific dietary patterns among children aged 2-9 years from eight European countries participating in the IDEFICS study and assessed the association of dietary patterns with an additive SES indicator. Children aged 2-9 years from eight European countries were recruited in 2007-2008. Principal component analysis was applied to identify dietary country-specific patterns. Linear regression analyses were applied to assess their association with SES. Two to four dietary patterns were identified in the participating regions. The existence of a 'processed' pattern was found in the eight regions. Also, a 'healthy' pattern was identified in seven of the eight regions. In addition, region-specific patterns were identified, reflecting the existing gastronomic and cultural differences in Europe. The 'processed' pattern was significantly inversely associated with the SES additive indicator in all countries except Sweden, whereas the 'healthy' pattern was positively associated with SES in the Belgian, Estonian, German and Hungarian regions, but was not significant in the Italian, Spanish and Swedish regions. A 'processed' pattern and a 'healthy' pattern were found in most of the participating countries in the IDEFICS study, with comparable food item profiles. The results showed a strong inverse association of SES with the 'processed' pattern, suggesting that children of parents with lower SES may be at higher risk of unhealthy eating. Therefore, special focus should be given to parents and their children from lower SES levels when developing healthy eating promotion strategies.

Combining CHAMP and Swarm Satellite Data to Invert the Lithospheric Magnetic Field in the Tibetan Plateau.

PubMed

Qiu, Yaodong; Wang, Zhengtao; Jiang, Weiping; Zhang, Bingbing; Li, Fupeng; Guo, Fei

2017-01-26

CHAMP and Swarm satellite magnetic data are combined to establish the lithospheric magnetic field over the Tibetan Plateau at satellite altitude by using zonal revised spherical cap harmonic analysis (R-SCHA). These data are integrated with geological structures data to analyze the relationship between magnetic anomaly signals and large-scale geological tectonic over the Tibetan Plateau and to explore the active tectonic region based on the angle of the magnetic anomaly. Results show that the model fitting error is small for a layer 250-500 km high, and the RMSE of the horizontal and radial geomagnetic components is better than 0.3 nT. The proposed model can accurately describe medium- to long-scale lithospheric magnetic anomalies. Analysis indicates that a negative magnetic anomaly in the Tibetan Plateau significantly differs with a positive magnetic anomaly in the surrounding area, and the boundary of the positive and negative regions is generally consistent with the geological tectonic boundary in the plateau region. Significant differences exist between the basement structures of the hinterland of the plateau and the surrounding area. The magnetic anomaly in the Central and Western Tibetan Plateau shows an east-west trend, which is identical to the direction of the geological structures. The magnetic anomaly in the eastern part is arc-shaped and extends along the northeast direction. Its direction is significantly different from the trend of the geological structures. The strongest negative anomaly is located in the Himalaya block, with a central strength of up to -9 nT at a height of 300 km. The presence of a strong negative anomaly implies that the Curie isotherm in this area is relatively shallow and deep geological tectonic activity may exist.

Combining CHAMP and Swarm Satellite Data to Invert the Lithospheric Magnetic Field in the Tibetan Plateau

PubMed Central

Qiu, Yaodong; Wang, Zhengtao; Jiang, Weiping; Zhang, Bingbing; Li, Fupeng; Guo, Fei

2017-01-01

CHAMP and Swarm satellite magnetic data are combined to establish the lithospheric magnetic field over the Tibetan Plateau at satellite altitude by using zonal revised spherical cap harmonic analysis (R-SCHA). These data are integrated with geological structures data to analyze the relationship between magnetic anomaly signals and large-scale geological tectonic over the Tibetan Plateau and to explore the active tectonic region based on the angle of the magnetic anomaly. Results show that the model fitting error is small for a layer 250–500 km high, and the RMSE of the horizontal and radial geomagnetic components is better than 0.3 nT. The proposed model can accurately describe medium- to long-scale lithospheric magnetic anomalies. Analysis indicates that a negative magnetic anomaly in the Tibetan Plateau significantly differs with a positive magnetic anomaly in the surrounding area, and the boundary of the positive and negative regions is generally consistent with the geological tectonic boundary in the plateau region. Significant differences exist between the basement structures of the hinterland of the plateau and the surrounding area. The magnetic anomaly in the Central and Western Tibetan Plateau shows an east–west trend, which is identical to the direction of the geological structures. The magnetic anomaly in the eastern part is arc-shaped and extends along the northeast direction. Its direction is significantly different from the trend of the geological structures. The strongest negative anomaly is located in the Himalaya block, with a central strength of up to −9 nT at a height of 300 km. The presence of a strong negative anomaly implies that the Curie isotherm in this area is relatively shallow and deep geological tectonic activity may exist. PMID:28134755

Geographic variation in species richness, rarity, and the selection of areas for conservation: An integrative approach with Brazilian estuarine fishes

NASA Astrophysics Data System (ADS)

Vilar, Ciro C.; Joyeux, Jean-Christophe; Spach, Henry L.

2017-09-01

While the number of species is a key indicator of ecological assemblages, spatial conservation priorities solely identified from species richness are not necessarily efficient to protect other important biological assets. Hence, the results of spatial prioritization analysis would be greatly enhanced if richness were used in association to complementary biodiversity measures. In this study, geographic patterns in estuarine fish species rarity (i.e. the average range size in the study area), endemism and richness, were mapped and integrated to identify regions important for biodiversity conservation along the Brazilian coast. Furthermore, we analyzed the effectiveness of the national system of protected areas to represent these regions. Analyses were performed on presence/absence data of 412 fish species in 0.25° latitudinal bands covering the entire Brazilian biogeographical province. Species richness, rarity and endemism patterns differed and strongly reflected biogeographical limits and regions. However, among the existing 154 latitudinal bands, 48 were recognized as conservation priorities by concomitantly harboring high estuarine fish species richness and assemblages of geographically rare species. Priority areas identified for all estuarine fish species largely differed from those identified for Brazilian endemics. Moreover, there was no significant correlation between the different aspects of the fish assemblages considered (i.e. species richness, endemism or rarity), suggesting that designating reserves based on a single variable may lead to large gaps in the overall protection of biodiversity. Our results further revealed that the existing system of protected areas is insufficient for representing the priority bands we identified. This highlights the urgent need for expanding the national network of protected areas to maintain estuarine ecosystems with high conservation value.

Mood-dependent integration in discourse comprehension: happy and sad moods affect consistency processing via different brain networks.

PubMed

Egidi, Giovanna; Caramazza, Alfonso

2014-12-01

According to recent research on language comprehension, the semantic features of a text are not the only determinants of whether incoming information is understood as consistent. Listeners' pre-existing affective states play a crucial role as well. The current fMRI experiment examines the effects of happy and sad moods during comprehension of consistent and inconsistent story endings, focusing on brain regions previously linked to two integration processes: inconsistency detection, evident in stronger responses to inconsistent endings, and fluent processing (accumulation), evident in stronger responses to consistent endings. The analysis evaluated whether differences in the BOLD response for consistent and inconsistent story endings correlated with self-reported mood scores after a mood induction procedure. Mood strongly affected regions previously associated with inconsistency detection. Happy mood increased sensitivity to inconsistency in regions specific for inconsistency detection (e.g., left IFG, left STS), whereas sad mood increased sensitivity to inconsistency in regions less specific for language processing (e.g., right med FG, right SFG). Mood affected more weakly regions involved in accumulation of information. These results show that mood can influence activity in areas mediating well-defined language processes, and highlight that integration is the result of context-dependent mechanisms. The finding that language comprehension can involve different networks depending on people's mood highlights the brain's ability to reorganize its functions. Copyright © 2014 Elsevier Inc. All rights reserved.

Characterizing the associative content of brain structures involved in habitual and goal-directed actions in humans: a multivariate FMRI study.

PubMed

McNamee, Daniel; Liljeholm, Mimi; Zika, Ondrej; O'Doherty, John P

2015-03-04

While there is accumulating evidence for the existence of distinct neural systems supporting goal-directed and habitual action selection in the mammalian brain, much less is known about the nature of the information being processed in these different brain regions. Associative learning theory predicts that brain systems involved in habitual control, such as the dorsolateral striatum, should contain stimulus and response information only, but not outcome information, while regions involved in goal-directed action, such as ventromedial and dorsolateral prefrontal cortex and dorsomedial striatum, should be involved in processing information about outcomes as well as stimuli and responses. To test this prediction, human participants underwent fMRI while engaging in a binary choice task designed to enable the separate identification of these different representations with a multivariate classification analysis approach. Consistent with our predictions, the dorsolateral striatum contained information about responses but not outcomes at the time of an initial stimulus, while the regions implicated in goal-directed action selection contained information about both responses and outcomes. These findings suggest that differential contributions of these regions to habitual and goal-directed behavioral control may depend in part on basic differences in the type of information that these regions have access to at the time of decision making. Copyright © 2015 the authors 0270-6474/15/353764-08$15.00/0.

Characteristics of X-Ray Emission from the PFRC-2 Capacitively Coupled Plasma

NASA Astrophysics Data System (ADS)

Oliver, Richard; Pearcy, Jacob; Jandovitz, Peter; Swanson, Charles; Matteucci, Jackson; Cohen, Samuel; PFRC Team

2015-11-01

It is uncertain what causes keV X-rays emitted from the central-cell region of a cool (bulk Te ~ 4 eV), tenuous (ne ~1010 cm-3), 5 cm diameter, weakly ionized hydrogen plasma column generated in a tandem high-mirror-ratio mirror machine (PFRC-2 device) by a low-power, external, capacitively-coupled RF (27 MHz) antenna. We explored whether the energetic electrons responsible for the X-rays exist only in the central cell (ER) or also in the asymmetric mirror regions at opposite ends of the machine, as well as how the spectra compare if they do exist in both regions. To address this, we have designed, built, calibrated, installed and operated an X-ray detector system to view the PFRC-2 region near the RF antenna in one end cell (MC). We observe somewhat different X-ray spectra emanating from the two regions. The system comprises two Amptek XR-100CR detectors with moveable slits that scan across the plasma column. Further control of radial resolution (to 0.4 cm) is afforded by changing the detector-to-slit distance. Calibrations were performed with an 55Fe source. These data are being used to understand the source of the fast electrons that create the X-rays in the MC and in the ER. This work is supported by the US DOE Contract No. DE-AC02-09CH11466 and the Princeton Environmental Institute.

Are different parasite guilds of Pagrus pagrus equally suitable sources of information on host zoogeography?

PubMed

Soares, I A; Lanfranchi, A L; Luque, J L; Haimovici, M; Timi, J T

2018-06-01

Metazoan parasite assemblages of Pagrus pagrus inhabiting the southwestern Atlantic were analysed with the aim of identifying the existence of different stocks and to comparatively assess the value of different parasite guilds as indicators of zoogeographical regions. A total of 186 fish was examined. Samples were obtained from three Brazilian and one Argentine localities, distributed in three different biogeographic districts of the Argentine Zoogeographical Province. Pagrus pagrus harboured 26 metazoan parasite species distributed in three guilds, ectoparasites (10 species), long-lived larval endoparasites and short-lived gastrointestinal endoparasites (eight species each). Prevalence and abundance values of the former two guilds allowed analysing them comparatively to assess their value as biological indicators of both host population structure and zoogeography. Results of analyses on long-lived parasites evidenced the existence of three stocks, one in the regions of Rio de Janeiro and Sao Paulo, other in southern Brazil (Rio Grande do Sul) and a third in northern Argentina (Mar del Plata), responding to the differential environmental conditions characteristic of three zoogeographical ecoregions. Ectoparasite assemblages exhibited significant differences between all pairs of samples, including those considered as a single stock according to data on persistent parasites. Assemblages of long-lived larval parasites are considered as better indicators for stock assessment purposes than ectoparasites, whose population parameters were variable temporally and heterogeneous at small spatial scales. The distributional variability of persistent parasites of P. pagrus along large scales provides valuable information to help defining robust biogeographical patterns, applicable to stock identification and fishery management of this species.

Health Disparity and Cancer Health Disparity in China.

PubMed

Wang, Qi; Jiao, Jie

2016-01-01

China is one of the largest and most populated countries in the world. It has undergone rapid economic growth in recent years. However, the development is not equitable, and the distribution of wealth significantly varies among the regions in China. Geographical and socioeconomic inequalities, together with the lack of an equitable national social support system, cause the high variance of health outcomes among the regions. Furthermore, the fast growth of the economy has evoked many environmental challenges and puts much pressure on the population. The severe environmental deterioration, especially of the atmosphere and water bodies, has affected the health of the people living in China. As a result, cancer has become a major public health issue, and an alarming increase in incidence and mortality has been reported. However, cancer incidence and mortality vary in different areas in China. Cancer and cancer treatment disparities have existed for years. This article will discuss the existing health and cancer disparities associated with the risk factors and how these disparities are managed in China.

Analytical solutions for benchmarking cold regions subsurface water flow and energy transport models: one-dimensional soil thaw with conduction and advection

USGS Publications Warehouse

Kurylyk, Barret L.; McKenzie, Jeffrey M; MacQuarrie, Kerry T. B.; Voss, Clifford I.

2014-01-01

Numerous cold regions water flow and energy transport models have emerged in recent years. Dissimilarities often exist in their mathematical formulations and/or numerical solution techniques, but few analytical solutions exist for benchmarking flow and energy transport models that include pore water phase change. This paper presents a detailed derivation of the Lunardini solution, an approximate analytical solution for predicting soil thawing subject to conduction, advection, and phase change. Fifteen thawing scenarios are examined by considering differences in porosity, surface temperature, Darcy velocity, and initial temperature. The accuracy of the Lunardini solution is shown to be proportional to the Stefan number. The analytical solution results obtained for soil thawing scenarios with water flow and advection are compared to those obtained from the finite element model SUTRA. Three problems, two involving the Lunardini solution and one involving the classic Neumann solution, are recommended as standard benchmarks for future model development and testing.

First results of a study on turbulent boundary layers in oscillating flow with a mean adverse pressure gradient

NASA Technical Reports Server (NTRS)

Houdeville, R.; Cousteix, J.

1979-01-01

The development of a turbulent unsteady boundary layer with a mean pressure gradient strong enough to induce separation, in order to complete the extend results obtained for the flat plate configuration is presented. The longitudinal component of the velocity is measured using constant temperature hot wire anemometer. The region where negative velocities exist is investigated with a laser Doppler velocimeter system with BRAGG cells. The boundary layer responds by forced pulsation to the perturbation of potential flow. The unsteady effects observed are very important. The average location of the zero skin friction point moves periodically at the perturbation frequency. Average velocity profiles from different instants in the cycle are compared. The existence of a logarithmic region enables a simple calculation of the maximum phase shift of the velocity in the boundary layer. An attempt of calculation by an integral method of boundary layer development is presented, up to the point where reverse flow starts appearing.

Health Disparity and Cancer Health Disparity in China

PubMed Central

Wang, Qi; Jiao, Jie

2016-01-01

China is one of the largest and most populated countries in the world. It has undergone rapid economic growth in recent years. However, the development is not equitable, and the distribution of wealth significantly varies among the regions in China. Geographical and socioeconomic inequalities, together with the lack of an equitable national social support system, cause the high variance of health outcomes among the regions. Furthermore, the fast growth of the economy has evoked many environmental challenges and puts much pressure on the population. The severe environmental deterioration, especially of the atmosphere and water bodies, has affected the health of the people living in China. As a result, cancer has become a major public health issue, and an alarming increase in incidence and mortality has been reported. However, cancer incidence and mortality vary in different areas in China. Cancer and cancer treatment disparities have existed for years. This article will discuss the existing health and cancer disparities associated with the risk factors and how these disparities are managed in China. PMID:28083550

Recombination rate and the distribution of transposable elements in the Drosophila melanogaster genome.

PubMed

Rizzon, Carène; Marais, Gabriel; Gouy, Manolo; Biémont, Christian

2002-03-01

We analyzed the distribution of 54 families of transposable elements (TEs; transposons, LTR retrotransposons, and non-LTR retrotransposons) in the chromosomes of Drosophila melanogaster, using data from the sequenced genome. The density of LTR and non-LTR retrotransposons (RNA-based elements) was high in regions with low recombination rates, but there was no clear tendency to parallel the recombination rate. However, the density of transposons (DNA-based elements) was significantly negatively correlated with recombination rate. The accumulation of TEs in regions of reduced recombination rate is compatible with selection acting against TEs, as selection is expected to be weaker in regions with lower recombination. The differences in the relationship between recombination rate and TE density that exist between chromosome arms suggest that TE distribution depends on specific characteristics of the chromosomes (chromatin structure, distribution of other sequences), the TEs themselves (transposition mechanism), and the species (reproductive system, effective population size, etc.), that have differing influences on the effect of natural selection acting against the TE insertions.

Optical Properties of Al-Doped ZnO Films in the Infrared Region and Their Absorption Applications

NASA Astrophysics Data System (ADS)

Zheng, Hua; Zhang, Rong-Jun; Li, Da-Hai; Chen, Xin; Wang, Song-You; Zheng, Yu-Xiang; Li, Meng-Jiao; Hu, Zhi-Gao; Dai, Ning; Chen, Liang-Yao

2018-05-01

The optical properties of aluminum-doped zinc oxide (AZO) thin films were calculated rapidly and accurately by point-by-point analysis from spectroscopic ellipsometry (SE) data. It was demonstrated that there were two different physical mechanisms, i.e., the interfacial effect and crystallinity, for the thickness-dependent permittivity in the visible and infrared regions. In addition, there was a blue shift for the effective plasma frequency of AZO when the thickness increased, and the effective plasma frequency did not exist for AZO ultrathin films (< 25 nm) in the infrared region, which demonstrated that AZO ultrathin films could not be used as a negative index metamaterial. Based on detailed permittivity research, we designed a near-perfect absorber at 2-5 μm by etching AZO-ZnO alternative layers. The alternative layers matched the phase of reflected light, and the void cylinder arrays extended the high absorption range. Moreover, the AZO absorber demonstrated feasibility and applicability on different substrates.

Evaluating the Value of High Spatial Resolution in National Capacity Expansion Models using ReEDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krishnan, Venkat; Cole, Wesley

2016-11-14

Power sector capacity expansion models (CEMs) have a broad range of spatial resolutions. This paper uses the Regional Energy Deployment System (ReEDS) model, a long-term national scale electric sector CEM, to evaluate the value of high spatial resolution for CEMs. ReEDS models the United States with 134 load balancing areas (BAs) and captures the variability in existing generation parameters, future technology costs, performance, and resource availability using very high spatial resolution data, especially for wind and solar modeled at 356 resource regions. In this paper we perform planning studies at three different spatial resolutions--native resolution (134 BAs), state-level, and NERCmore » region level--and evaluate how results change under different levels of spatial aggregation in terms of renewable capacity deployment and location, associated transmission builds, and system costs. The results are used to ascertain the value of high geographically resolved models in terms of their impact on relative competitiveness among renewable energy resources.« less

Mycoplasmas hyorhinis in different regions of cuba. diagnosis

PubMed Central

Lobo, Evelyn; Poveda, Carlos; Gupta, Rakesh; Suarez, Alejandro; Hernández, Yenney; Ramírez, Ana; Poveda, José B.

2011-01-01

M. hyorhinis is considered one of the etiological agents of arthritis in sucking pigs, but recently as seen, some strains can produce pneumonia that could not be distinguished from the mycoplasmosis caused by M. hyopneumoniae. The study was conducted to research the presence of Mycoplasma hyorhinis (M. hyorhinis ) in different regions of the country from exudates of pig lungs with typical EP lesions. Exudates from 280 pig lungs with typical EP lesions were studied using molecular techniques such as PCR, real time PCR and amplification of the 16S-23S rRNA. It was detected that the 66% of the samples studied resulted positive to M. hyorhinis, and the presence of this species was detected in all the provinces. Amplification and studies on the intergenic region 16S-23S of M. hyorhinis rRNA demonstrated the existing variability among strains of a same species. This study is the first report on M. hyorhinis detection in Cuba. PMID:24031686

Two-phase flows and heat transfer within systems with ambient pressure above the thermodynamic critical pressure

NASA Technical Reports Server (NTRS)

Hendricks, R. C.; Braun, M. J.; Mullen, R. L.

1986-01-01

In systems where the design inlet and outlet pressures P sub amb are maintained above the thermodynamic critical pressure P sub c, it is often assumed that heat and mass transfer are governed by single-phase relations and that two-phase flows cannot occur. This simple rule of thumb is adequate in many low-power designs but is inadequate for high-performance turbomachines, boilers, and other systems where two-phase regions can exist even though P sub amb P sub c. Heat and mass transfer and rotordynamic-fluid-mechanic restoring forces depend on momentum differences, and those for a two-phase zone can differ significantly from those for a single-phase zone. By using a laminar, variable-property bearing code and a rotating boiler code, pressure and temperature surfaces were determined that illustrate nesting of a two-phase region within a supercritical pressure region. The method of corresponding states is applied to bearings with reasonable rapport.

Two-phase flows and heat transfer within systems with ambient pressure above the thermodynamic critical pressure

NASA Technical Reports Server (NTRS)

Hendricks, R. C.; Braun, M. J.; Mullen, R. L.

1986-01-01

In systems where the design inlet and outlet pressure P sub amb are maintained above the thermodynamic critical pressure P sub c, it is often assumed that heat and mass transfer are governed by single-phase relations and that two-phase flows cannot occur. This simple rule of thumb is adequate in many low-power designs but is inadequate for high-performance turbomachines, boilers, and other systems where two-phase regions can exist even though P sub amb P sub c. Heat and mass transfer and rotordynamic-fluid-mechanic restoring forces depend on momentum differences, and those for a two-phase zone can differ significantly from those for a single-phase zone. By using a laminar, variable-property bearing code and a rotating boiler code, pressure and temperature surfaces were determined that illustrate nesting of a two-phase region within a supercritical pressure region. The method of corresponding states is applied to bearings with reasonable rapport.

Satellite-Sensor Calibration Verification Using the Cloud-Shadow Method

NASA Technical Reports Server (NTRS)

Reinersman, P.; Carder, K. L.; Chen, F. R.

1995-01-01

An atmospheric-correction method which uses cloud-shaded pixels together with pixels in a neighboring region of similar optical properties is described. This cloud-shadow method uses the difference between the total radiance values observed at the sensor for these two regions, thus removing the nearly identical atmospheric radiance contributions to the two signals (e.g. path radiance and Fresnel-reflected skylight). What remains is largely due to solar photons backscattered from beneath the sea to dominate the residual signal. Normalization by the direct solar irradiance reaching the sea surface and correction for some second-order effects provides the remote-sensing reflectance of the ocean at the location of the neighbor region, providing a known 'ground target' spectrum for use in testing the calibration of the sensor. A similar approach may be useful for land targets if horizontal homogeneity of scene reflectance exists about the shadow. Monte Carlo calculations have been used to correct for adjacency effects and to estimate the differences in the skylight reaching the shadowed and neighbor pixels.

Testing the sensitivity of trade linkages in Europe to compound drought events

NASA Astrophysics Data System (ADS)

Veldkamp, Ted; Koks, Elco; Thissen, Mark; Wahl, Thomas; Haigh, Ivan; Muis, Sanne; Ward, Philip

2017-04-01

Droughts can be defined as spatially extensive events that are characterized by temporal deficits in precipitation, soil moisture or streamflow, and have the potential to cause large direct and indirect economic losses. Many European countries face drought as an economically important hazard, with agriculture, livestock, forestry, energy, industry, and water sectors particularly at risk, causing economic losses of 139 billion US over the past 30 years. Apart from these direct impacts, business production and the flow of goods and services can be affected indirectly by droughts. With consequences that can propagate through the economic system affecting regions not directly hit by the drought event itself, or in time-periods long after the original drought event occurred. In this study, we evaluate the sensitivity of existing trade linkages between the different NUTS-2 regions in Europe to the coupled occurrence of hydro-meteorological drought events, and their associated production losses. Using a multi-regional supply-use model for Europe, we have, on a product level, insight in the existing trade linkages between NUTS-2 regions. Using this information in combination with historical drought data, we assessed and identified for a selection of water related products: 1) the dependency-structures of the NUTS-2 regions within Europe for the import and export of products (and therein water); 2) the coupled nature of drought events occurring in regions that are linked via these trade-patterns; 3) the probability of not meeting demands (on a product level) due to drought events and the associated (indirect economic) impacts; and 4) regions that lose or benefit from their selection of trade-partners given the coupled nature of drought events, as well as the net effects for Europe as a whole.

The Invasive Liriomyza huidobrensis (Diptera: Agromyzidae): Understanding Its Pest Status and Management Globally

PubMed Central

Scheffer, Sonja J.; Visser, Diedrich; Valladares, Graciela; Soares Correa, Alberto; Shepard, B. Merle; Rauf, Aunu; Murphy, Sean T.; Mujica, Norma; MacVean, Charles; Kroschel, Jürgen; Kishinevsky, Miriam; Joshi, Ravindra C.; Johansen, Nina S.; Hallett, Rebecca H.; Civelek, Hasan S.; Chen, Bing; Metzler, Helga Blanco

2017-01-01

Liriomyza huidobrensis (Blanchard) is native to South America but has expanded its range and invaded many regions of the world, primarily on flowers and to a lesser extent on horticultural product shipments. As a result of initial invasion into an area, damage caused is usually significant but not necessarily sustained. Currently, it is an economic pest in selected native and invaded regions of the world. Adults cause damage by puncturing abaxial and adaxial leaf surfaces for feeding and egg laying sites. Larvae mine the leaf parenchyma tissues which can lead to leaves drying and wilting. We have recorded 365 host plant species from 49 families and more than 106 parasitoid species. In a subset of the Argentinian data, we found that parasitoid community composition attacking L. huidobrensis differs significantly in cultivated and uncultivated plants. No such effect was found at the world level, probably due to differences in collection methods in the different references. We review the existing knowledge as a means of setting the context for new and unpublished data. The main objective is to provide an update of widely dispersed and until now unpublished data, evaluate dispersion of the leafminer and management strategies in different regions of the world, and highlight the need to consider the possible effects of climate change on further regional invasions or expansions. PMID:28423426

The spliced leader trans-splicing mechanism in different organisms: molecular details and possible biological roles

PubMed Central

Bitar, Mainá; Boroni, Mariana; Macedo, Andréa M.; Machado, Carlos R.; Franco, Glória R.

2013-01-01

The spliced leader (SL) is a gene that generates a functional ncRNA that is composed of two regions: an intronic region of unknown function (SLi) and an exonic region (SLe), which is transferred to the 5′ end of independent transcripts yielding mature mRNAs, in a process known as spliced leader trans-splicing (SLTS). The best described function for SLTS is to solve polycistronic transcripts into monocistronic units, specifically in Trypanosomatids. In other metazoans, it is speculated that the SLe addition could lead to increased mRNA stability, differential recruitment of the translational machinery, modification of the 5′ region or a combination of these effects. Although important aspects of this mechanism have been revealed, several features remain to be elucidated. We have analyzed 157 SLe sequences from 148 species from seven phyla and found a high degree of conservation among the sequences of species from the same phylum, although no considerable similarity seems to exist between sequences of species from different phyla. When analyzing case studies, we found evidence that a given SLe will always be related to a given set of transcripts in different species from the same phylum, and therefore, different SLe sequences from the same species would regulate different sets of transcripts. In addition, we have observed distinct transcript categories to be preferential targets for the SLe addition in different phyla. This work sheds light into crucial and controversial aspects of the SLTS mechanism. It represents a comprehensive study concerning various species and different characteristics of this important post-transcriptional regulatory mechanism. PMID:24130571

Sex Differences in the Effect of Puberty on Hippocampal Morphology

PubMed Central

Satterthwaite, Theodore D.; Vandekar, Simon; Wolf, Daniel H.; Ruparel, Kosha; Roalf, David R.; Jackson, Chad; Elliott, Mark A.; Bilker, Warren B.; Calkins, Monica E.; Prabhakaran, Karthik; Davatzikos, Christos; Hakonarson, Hakon; Gur, Raquel E.; Gur, Ruben C.

2014-01-01

Objective Puberty is the defining process of adolescence, and is accompanied by divergent trajectories of behavior and cognition for males and females. Here we examine whether sex differences exist in the effect of puberty on the morphology of the hippocampus and amygdala. Method T1-weighted structural neuroimaging was performed in a sample of 524 pre- or postpubertal adolescents ages 10–22. Hippocampal and amygdala volume and shape were quantified using FSL’s FIRST procedure and scaled by intracranial volume. The effects on regional volume of age, sex, puberty, and their interactions were examined using linear regression. Postpubertal sex differences were examined using a vertex analysis. Results Prepubertal males and females had similar hippocampal volumes, whereas postpubertal females had significantly larger bilateral hippocampi, resulting in a significant puberty-by-sex interaction even when controlling for age and age-by-sex. This effect was regionally specific and was not apparent in the amygdala. Vertex analysis revealed that postpubertal differences were most prominent in the lateral aspect of the hippocampus bilaterally, corresponding to the CA1 subfield. Conclusions These results establish that there are regionally specific sex differences in the effect of puberty on the hippocampus. These findings are relevant for the understanding of psychiatric disorders that have both hippocampal dysfunction and prominent gender disparities during adolescence. PMID:24565361

Studies on Factors affecting the Evolution of Agroecosystems in the Dakotas

NASA Astrophysics Data System (ADS)

Arora, Gaurav

This dissertation combines remote sensing and applied economics tools to study land use conversions in North Dakota and South Dakota that are tied to this region's overall socio-economic welfare. Specifically, the region's corn and soybeans cultivation expanded significantly over the past decade replacing the region's grasslands and grain crops. In paper I, we estimate the localized impacts of the advent of corn-based ethanol plants on the Dakotas' corn acreage. We implement a Difference-in-Difference framework through more flexible assumptions as the Parallel Paths assumption of the standard model fails to hold. We find strong trends in the Dakotas' corn acreage over the past decade, but surprisingly some ethanol plants were found to have a negative impact on local corn acreage. In paper II, we evaluate crop competitiveness due to heterogeneous weather impacts on crop yields, and then test whether annual weather fluctuations explain land allocations among the Dakotas' major land uses. Our integrated framework suggests that annual weather variability is an important determinant of regional land use decisions. Under the A1B emissions scenario of climate change, we find that the yields of all of the Dakotas' major crops will decline by 2031-2060 relative to 1981-2010, leading to lower (higher) spring wheat (alfalfa) acres in Eastern (Western) Dakotas. In paper III, we develop and implement a satellite image-processing algorithm to estimate historical land use acres using raw Landsat sensor data, thereby extending the existing Cropland Data Layers back to 1984 in eastern Dakotas. We demonstrate that the availability of a longer time-series is useful as the rate of land use change may differ among different time-spans. In paper IV, we evaluate the cost-effectiveness of grassland conservation easements when spatial spillovers are present among private landowners. We first develop a conceptual model to incorporate social spillovers in evaluating the role of easements in inhibiting grassland conversions. We empirically test whether social spillovers are present by estimating hazard rates of conversion as a function of neighborhood density of grasslands and easements. Our findings suggest that easements are strategic complements to existing grasslands in preventing grassland conversions in the Dakotas.

Interactive effects of genotype x environment on the live weight of GIFT Nile tilapias.

PubMed

Oliveira, Sheila N DE; Ribeiro, Ricardo P; Oliveira, Carlos A L DE; Alexandre, Luiz; Oliveira, Aline M S; Lopera-Barrero, Nelson M; Santander, Victor F A; Santana, Renan A C

2017-01-01

In this paper, the existence of a genotype x environment interaction for the average daily weight in GIFT Nile tilapia (Oreochromis niloticus) in different regions in the state of Paraná (Brazil) was analyzed. The heritability results were high in the uni-characteristic analysis: 0.71, 0.72 and 0.67 for the cities of Palotina (PL), Floriano (FL) and Diamond North (DN), respectively. Genetic correlations estimated in bivariate analyzes were weak with values between 0.12 for PL-FL, 0.06 for PL and 0.23 for DN-FL-DN. The Spearman correlation values were low, which indicated a change in ranking in the selection of animals in different environments in the study. There was heterogeneity in the phenotypic variance among the three regions and heterogeneity in the residual variance between PL and DN. The direct genetic gain was greater for the region with a DN value gain of 198.24 g/generation, followed by FL (98.73 g/generation) and finally PL (98.73 g/generation). The indirect genetic gains were lower than 0.37 and greater than 0.02 g/generation. The evidence of the genotype x environment interaction was verified, which indicated the phenotypic heterogeneity of the variances among the three regions, weak genetic correlation and modified rankings in the different environments.

Idiopathic Intracranial Hypertension-A Comparison of Clinical Characteristics Between 4 Medical Centers in Different Geographic Regions of the World.

PubMed

Rosenblatt, Amir; Klein, Ainat; Roemer, Ségolène; Borruat, François-Xavier; Meira, Dália; Silva, Marta; Gökçay, Figen; Çelebisoy, Neşe; Kesler, Anat

2016-09-01

Idiopathic intracranial hypertension (IIH) is a well-characterized syndrome, most commonly affecting obese women of childbearing age. Differences in its prevalence have been reported in various populations. The aim of this article was to determine whether differences in clinical presentation and management exist for patients with IIH between different regions the world. Retrospective database analysis of adult patients with IIH from 4 different neuro-ophthalmology clinics. The data collected included gender, age of onset, body mass index (BMI), lumbar puncture opening pressure, initial visual acuity (VA), initial visual field (VF) mean deviation (MD), pharmacological or surgical treatment, length of follow-up, final VA, and final VF MD. The study population consisted of 244 patients, with significant regional variations of female to male ratio. Overall, there was no significant difference regarding the age of diagnosis or the BMI. Acetazolamide was the first line of treatment in all groups but there was a difference between countries regarding second-line treatment, including the use of surgical interventions. Mean initial VA differed between groups but the final change in VA was the same among all the study groups. There are differences in IIH presentation, treatment, and response to therapy among different countries. International prospective studies involving multiple centers are needed to determine the potential influence of environmental and genetic factors on the development of IIH and to improve the management of this potentially blinding disorder.

Vulnerability and impacts of climate change on forest and freshwater wetland ecosystems in Nepal: A review.

PubMed

Lamsal, Pramod; Kumar, Lalit; Atreya, Kishor; Pant, Krishna Prasad

2017-12-01

Climate change (CC) threatens ecosystems in both developed and developing countries. As the impacts of CC are pervasive, global, and mostly irreversible, it is gaining worldwide attention. Here we review vulnerability and impacts of CC on forest and freshwater wetland ecosystems. We particularly look at investigations undertaken at different geographic regions in order to identify existing knowledge gaps and possible implications from such vulnerability in the context of Nepal along with available adaptation programs and national-level policy supports. Different categories of impacts which are attributed to disrupting structure, function, and habitat of both forest and wetland ecosystems are identified and discussed. We show that though still unaccounted, many facets of forest and freshwater wetland ecosystems of Nepal are vulnerable and likely to be impacted by CC in the near future. Provisioning ecosystem services and landscape-level ecosystem conservation are anticipated to be highly threatened with future CC. Finally, the need for prioritizing CC research in Nepal is highlighted to close the existing knowledge gap along with the implementation of adaptation measures based on existing location specific traditional socio-ecological system.

3D multimodal MRI brain glioma tumor and edema segmentation: a graph cut distribution matching approach.

PubMed

Njeh, Ines; Sallemi, Lamia; Ayed, Ismail Ben; Chtourou, Khalil; Lehericy, Stephane; Galanaud, Damien; Hamida, Ahmed Ben

2015-03-01

This study investigates a fast distribution-matching, data-driven algorithm for 3D multimodal MRI brain glioma tumor and edema segmentation in different modalities. We learn non-parametric model distributions which characterize the normal regions in the current data. Then, we state our segmentation problems as the optimization of several cost functions of the same form, each containing two terms: (i) a distribution matching prior, which evaluates a global similarity between distributions, and (ii) a smoothness prior to avoid the occurrence of small, isolated regions in the solution. Obtained following recent bound-relaxation results, the optima of the cost functions yield the complement of the tumor region or edema region in nearly real-time. Based on global rather than pixel wise information, the proposed algorithm does not require an external learning from a large, manually-segmented training set, as is the case of the existing methods. Therefore, the ensuing results are independent of the choice of a training set. Quantitative evaluations over the publicly available training and testing data set from the MICCAI multimodal brain tumor segmentation challenge (BraTS 2012) demonstrated that our algorithm yields a highly competitive performance for complete edema and tumor segmentation, among nine existing competing methods, with an interesting computing execution time (less than 0.5s per image). Copyright © 2014 Elsevier Ltd. All rights reserved.

Properties of magnetic photonic crystals in the visible spectral region and their performance limitations

NASA Astrophysics Data System (ADS)

Kotov, V. A.; Shavrov, V. G.; Vasiliev, M.; Alameh, K.; Nur-E-Alam, M.; Balabanov, D. E.

2018-02-01

We report on the results of computer modelling and performance analysis of the optical and magneto-optical (MO) characteristics of one-dimensional magnetic photonic crystals (MPC) of several classic design types (having either a single structure defect, or a number of these), designed for applications in the visible spectral region. The calculations are performed accounting for the real levels of optical absorption achievable in existing MO materials which currently demonstrate the best MO quality (bismuth-substituted ferrite garnets). We consider Bi2Dy1Fe4Ga1O12 as the base material for use within quarter-wave thick MO layers of MPC; silica is used for the non-magnetic transparent quarter-wave layers. The achieved results can be used to clarify the nature of the differences that exist between the expected practical potential of MPCs in integrated photonics, and the actual attained experimental results. Our results show that in MPCs optimized for light intensity modulation applications, in the red spectral region (near 650 nm), the achievable levels of optical transmission are limited to about 30%. This coincides spectrally with the peaks of Faraday rotation reaching their maxima at about 25°, with further transmission increases possible in the near-infrared region. Larger Faraday rotation angles are only achievable currently in structures or single film layers with reduced transmission.

Impacts of Climate Change on Vector Borne Diseases in the Mediterranean Basin - Implications for Preparedness and Adaptation Policy.

PubMed

Negev, Maya; Paz, Shlomit; Clermont, Alexandra; Pri-Or, Noemie Groag; Shalom, Uri; Yeger, Tamar; Green, Manfred S

2015-06-15

The Mediterranean region is vulnerable to climatic changes. A warming trend exists in the basin with changes in rainfall patterns. It is expected that vector-borne diseases (VBD) in the region will be influenced by climate change since weather conditions influence their emergence. For some diseases (i.e., West Nile virus) the linkage between emergence andclimate change was recently proved; for others (such as dengue) the risk for local transmission is real. Consequently, adaptation and preparation for changing patterns of VBD distribution is crucial in the Mediterranean basin. We analyzed six representative Mediterranean countries and found that they have started to prepare for this threat, but the preparation levels among them differ, and policy mechanisms are limited and basic. Furthermore, cross-border cooperation is not stable and depends on international frameworks. The Mediterranean countries should improve their adaptation plans, and develop more cross-sectoral, multidisciplinary and participatory approaches. In addition, based on experience from existing local networks in advancing national legislation and trans-border cooperation, we outline recommendations for a regional cooperation framework. We suggest that a stable and neutral framework is required, and that it should address the characteristics and needs of African, Asian and European countries around the Mediterranean in order to ensure participation. Such a regional framework is essential to reduce the risk of VBD transmission, since the vectors of infectious diseases know no political borders.

Interactions between Private Health and Long-term Care Insurance and the Effects of the Crisis: Evidence for Spain.

PubMed

Jiménez-Martín, Sergi; Labeaga-Azcona, José M; Vilaplana-Prieto, Cristina

2016-11-01

This paper analyzes the reasons for the scarce development of the private long-term care insurance market in Spain, and its relationship with health insurance. We are also interested in the effects the crisis has had both on the evolution of the demand for long-term care insurance and on the existence of regional disparities. We estimate bivariate probit models with endogenous variables using Spanish data from the Survey on Health and Retirement in Europe. Our results confirm that individuals wishing to purchase long-term care insurance are, in a sense, forced to subscribe a health insurance policy. In spite of this restriction in the supply of long-term care insurance contracts, we find its demand has grown in recent years, which we attribute to the budget cuts affecting the implementation of Spain's System of Autonomy and Attention to Dependent People. Regional differences in its implementation, as well as the varying effects the crisis has had across Spanish regions, lead to the existence of a crowding-in effect in the demand for long-term care insurance in those regions where co-payment is based on income and wealth, those that have a lower percentage of public long-term care beneficiaries, or those with a smaller share of cash benefits over total public benefits. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Sequence and Characterization of the Ig Heavy Chain Constant and Partial Variable Region of the Mouse Strain 129S11

PubMed Central

Retter, Ida; Chevillard, Christophe; Scharfe, Maren; Conrad, Ansgar; Hafner, Martin; Im, Tschong-Hun; Ludewig, Monika; Nordsiek, Gabriele; Severitt, Simone; Thies, Stephanie; Mauhar, America; Blöcker, Helmut; Müller, Werner; Riblet, Roy

2009-01-01

Although the entire mouse genome has been sequenced, there remain challenges concerning the elucidation of particular complex and polymorphic genomic loci. In the murine Igh locus, different haplotypes exist in different inbred mouse strains. For example, the Ighb haplotype sequence of the Mouse Genome Project strain C57BL/6 differs considerably from the Igha haplotype of BALB/c, which has been widely used in the analyses of Ab responses. We have sequenced and annotated the 3′ half of the Igha locus of 129S1/SvImJ, covering the CH region and approximately half of the VH region. This sequence comprises 128 VH genes, of which 49 are judged to be functional. The comparison of the Igha sequence with the homologous Ighb region from C57BL/6 revealed two major expansions in the germline repertoire of Igha. In addition, we found smaller haplotype-specific differences like the duplication of five VH genes in the Igha locus. We generated a VH allele table by comparing the individual VH genes of both haplotypes. Surprisingly, the number and position of DH genes in the 129S1 strain differs not only from the sequence of C57BL/6 but also from the map published for BALB/c. Taken together, the contiguous genomic sequence of the 3′ part of the Igha locus allows a detailed view of the recent evolution of this highly dynamic locus in the mouse. PMID:17675503

Forensic DNA databases in Western Balkan region: retrospectives, perspectives, and initiatives

PubMed Central

Marjanović, Damir; Konjhodžić, Rijad; Butorac, Sara Sanela; Drobnič, Katja; Merkaš, Siniša; Lauc, Gordan; Primorac, Damir; Anđelinović, Šimun; Milosavljević, Mladen; Karan, Željko; Vidović, Stojko; Stojković, Oliver; Panić, Bojana; Vučetić Dragović, Anđelka; Kovačević, Sandra; Jakovski, Zlatko; Asplen, Chris; Primorac, Dragan

2011-01-01

The European Network of Forensic Science Institutes (ENFSI) recommended the establishment of forensic DNA databases and specific implementation and management legislations for all EU/ENFSI members. Therefore, forensic institutions from Bosnia and Herzegovina, Serbia, Montenegro, and Macedonia launched a wide set of activities to support these recommendations. To assess the current state, a regional expert team completed detailed screening and investigation of the existing forensic DNA data repositories and associated legislation in these countries. The scope also included relevant concurrent projects and a wide spectrum of different activities in relation to forensics DNA use. The state of forensic DNA analysis was also determined in the neighboring Slovenia and Croatia, which already have functional national DNA databases. There is a need for a ‘regional supplement’ to the current documentation and standards pertaining to forensic application of DNA databases, which should include regional-specific preliminary aims and recommendations. PMID:21674821

Automatic correction of dental artifacts in PET/MRI

PubMed Central

Ladefoged, Claes N.; Andersen, Flemming L.; Keller, Sune. H.; Beyer, Thomas; Law, Ian; Højgaard, Liselotte; Darkner, Sune; Lauze, Francois

2015-01-01

Abstract. A challenge when using current magnetic resonance (MR)-based attenuation correction in positron emission tomography/MR imaging (PET/MRI) is that the MRIs can have a signal void around the dental fillings that is segmented as artificial air-regions in the attenuation map. For artifacts connected to the background, we propose an extension to an existing active contour algorithm to delineate the outer contour using the nonattenuation corrected PET image and the original attenuation map. We propose a combination of two different methods for differentiating the artifacts within the body from the anatomical air-regions by first using a template of artifact regions, and second, representing the artifact regions with a combination of active shape models and k-nearest-neighbors. The accuracy of the combined method has been evaluated using 25 F18-fluorodeoxyglucose PET/MR patients. Results showed that the approach was able to correct an average of 97±3% of the artifact areas. PMID:26158104

GBA manager: an online tool for querying low-complexity regions in proteins.

PubMed

Bandyopadhyay, Nirmalya; Kahveci, Tamer

2010-01-01

Abstract We developed GBA Manager, an online software that facilitates the Graph-Based Algorithm (GBA) we proposed in our earlier work. GBA identifies the low-complexity regions (LCR) of protein sequences. GBA exploits a similarity matrix, such as BLOSUM62, to compute the complexity of the subsequences of the input protein sequence. It uses a graph-based algorithm to accurately compute the regions that have low complexities. GBA Manager is a user friendly web-service that enables online querying of protein sequences using GBA. In addition to querying capabilities of the existing GBA algorithm, GBA Manager computes the p-values of the LCR identified. The p-value gives an estimate of the possibility that the region appears by chance. GBA Manager presents the output in three different understandable formats. GBA Manager is freely accessible at http://bioinformatics.cise.ufl.edu/GBA/GBA.htm .

Intimations of water on Mars.

PubMed

2000-08-01

This photo essay contains images of Mars that propose evidence of the possible present or past existence of liquid water on Mars. Images were taken by the Mars Global Surveyor Mars Orbiter Camera. Images presented include: Polar Wall Pit region, consisting of gully landforms possibly caused by seepage and runoff of liquid water; Noachis Terra region, an area of gullies eroded into the wall of a meteor impact crater, where channels and related debris are seen, possibly formed by seepage, runoff, and debris flow; two images of Gorgonum Chaos region, one a series of troughs and layers of gullies and the other of gullies in a specific layer forming an alcove similar to an aquifer; Sirenum Fossae/Gorgonum Chaos mosaic of two images from this region of the southern hemisphere of Mars, showing 20 different channels coming down from a trough and their associated debris fans. Images and their enhancements are from NASA/JPL/Malin Space Science System.

Peace in the Clinic: Rethinking "Global Health Diplomacy" in the Somali Region of Ethiopia.

PubMed

Carruth, Lauren

2016-06-01

Drawing on ethnographic research with Somalis, within aid organizations, and within health care facilities in the Somali Region of Ethiopia, this article argues that what is called "global health diplomacy," despite its origins and articulations in interstate politics, is fundamentally local and interpersonal. As evidence, I outline two very different health programs in the Somali Region of Ethiopia, and how, in each, existing animosities and political grievances were either reinforced or undermined. I argue that the provision of health care in politically insecure and post-conflict settings like the Somali Region of Ethiopia is precarious but pivotal: medical encounters have the potential to either worsen the conditions in which conflicts and crises recur, or build new interpersonal and governmental relations of trust. Effective global health diplomacy, therefore, cannot be limited to building clinics and donating medicine, but must also explicitly include building positive relationships of trust between oppositional groups within clinical spaces.

Forensic DNA databases in Western Balkan region: retrospectives, perspectives, and initiatives.

PubMed

Marjanović, Damir; Konjhodzić, Rijad; Butorac, Sara Sanela; Drobnic, Katja; Merkas, Sinisa; Lauc, Gordan; Primorac, Damir; Andjelinović, Simun; Milosavljević, Mladen; Karan, Zeljko; Vidović, Stojko; Stojković, Oliver; Panić, Bojana; Vucetić Dragović, Andjelka; Kovacević, Sandra; Jakovski, Zlatko; Asplen, Chris; Primorac, Dragan

2011-06-01

The European Network of Forensic Science Institutes (ENFSI) recommended the establishment of forensic DNA databases and specific implementation and management legislations for all EU/ENFSI members. Therefore, forensic institutions from Bosnia and Herzegovina, Serbia, Montenegro, and Macedonia launched a wide set of activities to support these recommendations. To assess the current state, a regional expert team completed detailed screening and investigation of the existing forensic DNA data repositories and associated legislation in these countries. The scope also included relevant concurrent projects and a wide spectrum of different activities in relation to forensics DNA use. The state of forensic DNA analysis was also determined in the neighboring Slovenia and Croatia, which already have functional national DNA databases. There is a need for a 'regional supplement' to the current documentation and standards pertaining to forensic application of DNA databases, which should include regional-specific preliminary aims and recommendations.

Measurement of absolute regional lung air volumes from near-field x-ray speckles.

PubMed

Leong, Andrew F T; Paganin, David M; Hooper, Stuart B; Siew, Melissa L; Kitchen, Marcus J

2013-11-18

Propagation-based phase contrast x-ray (PBX) imaging yields high contrast images of the lung where airways that overlap in projection coherently scatter the x-rays, giving rise to a speckled intensity due to interference effects. Our previous works have shown that total and regional changes in lung air volumes can be accurately measured from two-dimensional (2D) absorption or phase contrast images when the subject is immersed in a water-filled container. In this paper we demonstrate how the phase contrast speckle patterns can be used to directly measure absolute regional lung air volumes from 2D PBX images without the need for a water-filled container. We justify this technique analytically and via simulation using the transport-of-intensity equation and calibrate the technique using our existing methods for measuring lung air volume. Finally, we show the full capabilities of this technique for measuring regional differences in lung aeration.

Geotechical Investigation of Landslides in Gurpinar Region

NASA Astrophysics Data System (ADS)

Karabulut, S.; Imre, N.; Dalgic, S.; Ozcep, F.

2012-04-01

Gürpinar in Beylikdüzü district in Istanbul, Rapid and uncontrolled construction have been exposed due to the current visual. Although to the previous zoning plan to covered a large part of the study area was recommended to use as green space, today's regulations have begun to define these areas as the areas mostly precautionary. With the development of engineering technology and knowledge, these areas were allowed to open of new structures to take necessary precautions. With increase in the effective construction in these regions, the existing slopes has led to start due to imbalance of mass movements. By using topographic map (1 / 5000 scale) and satellite images were examined in the region, the boundaries of existing landslides have been identified within the scope of this study. These areas are Çukurlar, Pınarkent, Pekmez and Onbeşevler. In addition to geophysical studies previously performed in the region; Seismic Reflection, Surface Wave Analysis (Active and Passive Source) and ground penetrating radar measurements were done. The geometry of surface planes and its depth, sand-gravel lenses, border of saturated clay units and the dynamic elastic parameters have been determined by using geophysical studies. The target depth of each method related to the properties of used sources or antenna and features of equipment. In Onbeşevler selected as pilot regions for georadar measurements, different water saturation at different depths s have been identified by using information taken from a depth of 30 meters. As a result of the geophysical studies, each in a landslide area, many slip plane have been identified and are given in sections. Geological cross-sections created for the workspace by using the drilling data and the pits belong to private companies and government agencies in the region. Inside the border of each landslides, the slope stability analysis done by using geological cross-sections and its physical parameters. Slope stability analysis made by using Slide program, safety coefficient were calculated using different slip planes obtained from geophysical parameters. Analysis were repeated for each slip plane for static and dynamic conditions. Examined to results of these slope stability analysis, safety coefficient have been identified below the limit values or very close to the border of even static conditions in Çukurlar, Pınarkent, Pekmez ve Onbeşevler's slope.

New business creation and technology transfer in the Rochester Cluster

NASA Astrophysics Data System (ADS)

DeMartino, Richard

2002-05-01

The Rochester, NY regional photonics industry is in a period a technological and organizational change. Over the past seventy years the regional has enjoyed a reputation as one of the premium optics and imaging (photonics systems) centers of the world. In the past, the driving force behind this preeminence was a small number of larger diversified companies with strong technological competencies and internally oriented operations. Supporting these firms were dozens of small optics, components, and imaging suppliers who grew and declined with their primary customers. Today's competitive photonics industry is far different technologically and organizationally then what existed 20 to 40 years ago.

A histomorphometric study of adaptive responses of cancellous bone in different regions in the sheep mandibular condyle following experimental forward mandibular displacement.

PubMed

Ma, Bingkui; Sampson, Wayne; Wilson, David; Wiebkin, Ole; Fazzalari, Nicola

2002-07-01

Forward mandibular displacement in animal models is associated with faster and/or redirected condylar growth. Here the effect of forward displacement induced with an intraoral appliance on modelling/remodelling of the mandibular condyle was investigated in eight, 4-month-old, castrated male Merino sheep, randomly allocated to experimental and control groups (n=4 in each group). The study period was 15 weeks, during that time, (1). calcein, (2). tetracycline, and (3). alizarin red S fluorochromes were given to all animals from day 1. Midsagittal sections of the temporomandibular joints were selected for analysis. Dynamic variables of bone formation, static indices of bone-forming and -resorbing activity, and structural indices of trabecular bone were estimated histomorphometrically. The sampling site was divided into two regions for analysis: (a). a 'subchondral region' (2 and 3 labels only), believed to be the bone newly formed during the experimental period; (b). a 'central region' (labelled by all three fluorochromes), believed to be the bone that existed before the experiment. Regional differences in adaptive response were found. In the experimental group, the bone-volume fraction (BV/TV) of the subchondral regions had decreased, although the specific bone-surface and bone-formation rates had increased. This low BV/TV was associated with decreased trabecular thickness and increased trabecular separation. In the central condylar region of the experimental group, BV/TV was unchanged, but an increased osteoid surface was apparent when the eroded surface was taken into consideration. These adaptive condylar responses to forward mandibular displacement appeared to be the result of increased osteoblastic activity. Further studies are recommended to examine why the subchondral and central regions responded differently.

Supportive care services in hemato-oncology centers: a national survey.

PubMed

Mercadante, Sebastiano; Costanzi, Andrea; David, Fabrizio; Villari, Patrizia; Musso, Maurizio; Marchetti, Paolo; Casuccio, Alessandra

2016-10-01

In the field of hemato-oncology, there is paucity of data assessing models of integration between hemato-oncology and other partner specialties. The aim of this national survey was to gather information about the status of the integration of this kind of activity in hemato-oncologic units existing in Italy. A national telephone survey was conducted to gather information about the status of the integration of hemato-oncologic and supportive care/anesthesiological services. From the national registry of hemato-oncology units, 149 centers were contacted by phone and a dedicated doctor was identified to gather information about the center through a telephone interview. Eighty-one centers (54.3 %) agreed to participate. A mean of 206 (SD 132) painful procedures/year/center were performed. No significant differences among regions and centers were found (P = 0.680). Of the centers, 41.9 % usually asked for anesthesiological consultation to perform painful procedures. No differences were found between the regions (P = 0.137). A mean of 1.8 (SD 1.2) days elapsed from the request to the procedure performance (P = 0.271). No differences among the regions were found (P = 0.350). A mean of 220 (SD 89) central venous vascular accesses/year/center were performed. No differences among regions were found (P = 0.170). No differences among the centers were found (P = 0.691). A mean of 1.8 (SD 1.2) days elapsed from the request to the performance of procedure. Of the centers, 64.2 % had a palliative care team. No differences among regions were found (P = 0.331). A mean of 31.5 (SD 12.2) consultations/year/center for pain control were required. No differences among the regions were found (P = 0.556). Of the centers, 30.8 % had some beds for palliative care. No differences among the regions were found (P = 0.641). Of the centers, 32 % had a hospice was available. No differences among regions were found (P = 0.298). Integration between hemato-oncology and other professionals is unlikely to be optimal in Italy. Such integration is complex and needs great efforts to solve several organizational problems.

78 FR 59911 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

...: Importation of Table Eggs from Regions Where Newcastle Disease Exists. OMB Control Number: 0579-0328. Summary... Federal Regulations, section 94.6 deal specifically with the importation of table eggs from certain... exist, the United States is not currently importing table eggs from any END-affected region. APHIS...

9 CFR 94.10 - Swine from regions where classical swine fever exists.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Swine from regions where classical swine fever exists. 94.10 Section 94.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... SWINE FEVER, CLASSICAL SWINE FEVER, SWINE VESICULAR DISEASE, AND BOVINE SPONGIFORM ENCEPHALOPATHY...

Simulation and performance evaluation of fiber optic sensor for detection of hepatic malignancies in human liver tissues

NASA Astrophysics Data System (ADS)

Sharma, Anuj K.; Gupta, Jyoti; Basu, Rikmantra

2018-01-01

A fiber optic sensor is proposed for the identification of healthy and cancerous liver tissues through determination of their corresponding refractive index values. Existing experimental results describing variation of complex refractive index of liver tissues in near infrared (NIR) spectral region are considered for theoretical calculations. The intensity interrogation method with chalcogenide fiber is considered. The sensor's performance is closely analyzed in terms of its sensitivity at multiple operating wavelengths falling in NIR region. Operating at shorter NIR wavelengths leads to greater sensitivity. The effect of design parameters (sensing region length and fiber core diameter), different launching conditions, and fiber glass materials on sensor's performance is examined. The proposed sensor has the potential to provide high sensitivity of liver tissue detection.

Industrial melanism in British peppered moths has a singular and recent mutational origin.

PubMed

van't Hof, Arjen E; Edmonds, Nicola; Dalíková, Martina; Marec, Frantisek; Saccheri, Ilik J

2011-05-20

The rapid spread of a novel black form (known as carbonaria) of the peppered moth Biston betularia in 19th-century Britain is a textbook example of how an altered environment may produce morphological adaptation through genetic change. However, the underlying genetic basis of the difference between the wild-type (light-colored) and carbonaria forms has remained unknown. We have genetically mapped the carbonaria morph to a 200-kilobase region orthologous to a segment of silkworm chromosome 17 and show that there is only one core sequence variant associated with the carbonaria morph, carrying a signature of recent strong selection. The carbonaria region coincides with major wing-patterning loci in other lepidopteran systems, suggesting the existence of basal color-patterning regulators in this region.

Transmission of sound across a vortex layer enclosing a cylindrical column of jet

NASA Technical Reports Server (NTRS)

Luh, R.; Chao, C. C.

1982-01-01

An approximate solution to the problem of transmission of sound across a cylindrical vortex was obtained. Results are considerably different from the plane vortex sheet case because of the added role played by the curvature of the jet. In comparison with the plane case, the specularly transmitted waves are more complex and require some numerical integration. Resonance waves are identically predicted for M 2, but there is also a wave field whose modified effect appears to extend the region of resonance just as the instability waves cover a region in space and time. The instability waves are predicted to exist for all Mach numbers but vanish for wavelengths that are large compared to the jet radius. The region of propagation is similarly wavelength dependent.

S U (2 ) Chern-Simons theory coupled to competing scalars

NASA Astrophysics Data System (ADS)

Pérez Ipiña, J. M.; Schaposnik, F. A.; Tallarita, G.

2018-06-01

We study a spontaneously broken S U (2 ) Chern-Simons-Higgs model coupled though a Higgs portal to an uncharged triplet scalar with a vacuum state competing with the Higgs one. We find vortexlike solutions to the field equations in different parameter space regions. Depending on the scalar coupling constants, we find a parameter region in which the competing order creates a halo about the Chern-Simons-Higgs vortex core, together with two other regions, one where no vortex solutions exist and the other where ordinary Chern-Simons-Higgs vortices can be found. We derive the low-energy theory for the moduli fields on the vortex world sheet and also discuss the connection of our results with those found in studies of competing orders in high-temperature superconductors.

Spatial and temporal variation of correlation between the Arctic total ozone and atmospheric temperature

NASA Astrophysics Data System (ADS)

Huang, Fuxiang; Ren, suling; Han, Shuangshuang; Zheng, xiangdong; Deng, xuejiao

2017-04-01

Daily total ozone and atmospheric temperature profile data in 2015 from the AIRS are used to investigate the spatial and temporal variation of the correlation between the Arctic atmospheric ozone and temperature. In the study, 11 lays atmospheric temperature profiles from the troposphere to the stratosphere are investigated. These layer heights are 20, 50, 70, 100, 200, 250, 300, 400, 500, 600 and 700 hPa respectively. The results show that a significant seasonal split exists in the correlation between the Arctic ozone and atmospheric temperature. Figure 1 shows the spatial and temporal variation of the coefficient between the atmospheric ozone and temperature at 50hPa. It can be seen from the figure that an obvious spatiotemporal difference exists in the correlation between the Arctic total ozone and atmospheric temperature in the lower stratosphere. First, the seasonal difference is very remarkable, which is shown as a significant positive correlation in most regions during winter and summer, while no correlation in the majority of regions occurs during spring and autumn, with a weak positive or negative correlation in a small number regions. Second, the spatial differences are also very obvious. The summer maximum correlation coefficient occurs in the Barents Sea and other locations at 0.8 and above, while the winter maximum occurs in the Baffin Bay area at 0.6 to 0.8. However, in a small number of regions, such as the land to the west of the Bering Strait in winter and the Arctic Ocean core area in summer, the correlation coefficients were unable to pass the significance test to show no correlation. At the same time, in spring and autumn, a positive correlation only occurs over a few low-latitude land areas, while over other Arctic areas, weak negative correlation exists. The differences in horizontal position are clearly related to the land-sea distribution, underlying surface characteristics, glacial melting, and other factors. In the troposphere, the ozone and temperature have a strong negative correlation in spring and autumn, while presenting a weak negative correlation or no correlation in winter and summer. Figure 2 shows the spatial and temporal variation of the correlation coefficient between the atmospheric ozone and temperature at 500hPa. From figure 2, it can be seen that in the Arctic troposphere, the atmospheric ozone and tropospheric temperature mainly have a negative correlation. In winter and summer, a weak negative correlation is shown overall, but more than a third of the regions show no correlation. In spring, the negative correlation is the strongest between the ozone and temperature. Especially in Greenland - Queen Elizabeth Islands and southern New Siberian Islands, the correlation is the highest, with a correlation coefficient of -0.9 and above, followed by a negative correlation in autumn. Except for a small number of low-latitude scattered regions with weak correlation, the correlation coefficients of most regions are ranged between -0.5 and -0.7. At 300 hPa near the tropopause, the horizontal distribution and seasonal change of the correlation between the Arctic total ozone and atmospheric temperature are as shown in Fig. 3.At the height near the Arctic tropopause, the atmospheric ozone mainly has no correlation to temperature, especially in winter and summer, when no correlation exists in the majority of regions, while weak positive or negative correlation occurs in a small number of areas. In the majority of regions during spring, a weak negative correlation is shown, while no correlation appears in Western Greenland - Queen Elizabeth Islands. In autumn, most regions show no correlation, while weak negative correlation is presented in Eastern Greenland, Norwegian Sea - Barents Sea, and other locations. From figure 1-3, we can see a significant difference exists from the common law of positive correlation in the lower stratosphere and negative correlation in the troposphere at mid-low latitudes. The Arctic atmospheric ozone has a relation with temperature, showing significant spatial and temporal variation characteristics. In the stratosphere, winter and summer atmospheric temperatures mainly have a positive correlation to ozone. The summer maximum occurs in the Barents Sea to achieve 0.8 and above, while the winter maximum is 0.6 to 0.8 in the Baffin Bay area. In the troposphere, the autumn and spring atmospheric temperatures mainly have a negative correlation to the ozone. The spring correlation coefficient in Greenland to the Queen Elizabeth Islands reaches up to -0.9 and above, while the autumn value is -0.5 to -0.7. At about 300 hPa, the tropopause value is reduced to 0, and further decreased in the troposphere, to show a strong negative correlation. Based on the comprehensive analysis of various influence factors, the possible action mechanism of the spatiotemporal variation pattern of the correlation between the Arctic atmospheric ozone and temperature is discussed based on the seasonal differences of various influence factors. The spatial and temporal variation characteristics of the correlation between the Arctic atmospheric ozone and temperature are determined by the seasonal variation of various influencing factors of the Arctic atmospheric ozone and temperature. These factors include the atmospheric heating effect from the ozone matching with the Arctic sunshine conditions, the influence of dynamic delivery on the ozone and heat, the impact of underlying-surface glacial melting on atmospheric radiation and heat budget, and so on. At different heights in each season, the different effects from all kinds of factors on the ozone and temperature determine the spatiotemporal variation of the correlation between the ozone and temperature.

Dividing the common pond: regionalizing EU ocean governance.

PubMed

Maier, Nina; Markus, Till

2013-02-15

EU ocean policies increasingly incorporate regional measures. Under the long standing Common Fisheries Policy, such measures aim at improving and reforming existing policy, either by taking into account region specific social or ecologic requirements or by establishing procedures and institutions to achieve a regional fit. By contrast, the EU's emerging integrated Marine Environmental Policy was designed to draw heavily on regional procedural and institutional mechanisms from the outset. The developing regional measures raise the question whether they contribute to improving institutional structures governing the use and conservation of EU waters. This article analyzes the existing and future regional measures of the two policies and their varying purposes and scopes. It develops a typology for categorizing the regional aspects and examines the effects of regional measures on EU institutions and the theoretical EU integration debate. Copyright © 2012 Elsevier Ltd. All rights reserved.

Theoretical studies of floating-reference method for NIR blood glucose sensing

NASA Astrophysics Data System (ADS)

Shi, Zhenzhi; Yang, Yue; Zhao, Huijuan; Chen, Wenliang; Liu, Rong; Xu, Kexin

2011-03-01

Non-invasive blood glucose monitoring using NIR light has been suffered from the variety of optical background that is mainly caused by the change of human body, such as the change of temperature, water concentration, and so on. In order to eliminate these internal influence and external interference a so called floating-reference method has been proposed to provide an internal reference. From the analysis of the diffuse reflectance spectrum, a position has been found where diffuse reflection of light is not sensitive to the glucose concentrations. Our previous work has proved the existence of reference position using diffusion equation. However, since glucose monitoring generally use the NIR light in region of 1000-2000nm, diffusion equation is not valid because of the high absorption coefficient and small source-detector separations. In this paper, steady-state high-order approximate model is used to further investigate the existence of the floating reference position in semi-infinite medium. Based on the analysis of different optical parameters on the impact of spatially resolved reflectance of light, we find that the existence of the floating-reference position is the result of the interaction of optical parameters. Comparing to the results of Monte Carlo simulation, the applicable region of diffusion approximation and higher-order approximation for the calculation of floating-reference position is discussed at the wavelength of 1000nm-1800nm, using the intralipid solution of different concentrations. The results indicate that when the reduced albedo is greater than 0.93, diffusion approximation results are more close to simulation results, otherwise the high order approximation is more applicable.

Institutional pioneers in world politics: Regional institution building and the influence of the European Union.

PubMed

Lenz, Tobias; Burilkov, Alexandr

2017-09-01

What drives processes of institution building within regional international organizations? We challenge those established theories of regionalism, and of institutionalized cooperation more broadly, that treat different organizations as independent phenomena whose evolution is conditioned primarily by internal causal factors. Developing the basic premise of 'diffusion theory' - meaning that decision-making is interdependent across organizations - we argue that institutional pioneers, and specifically the European Union, shape regional institution-building processes in a number of discernible ways. We then hypothesize two pathways - active and passive - of European Union influence, and stipulate an endogenous capacity for institutional change as a key scope condition for their operation. Drawing on a new and original data set on the institutional design of 34 regional international organizations in the period from 1950 to 2010, the article finds that: (1) both the intensity of a regional international organization's structured interaction with the European Union (active influence) and the European Union's own level of delegation (passive influence) are associated with higher levels of delegation within other regional international organizations; (2) passive European Union influence exerts a larger overall substantive effect than active European Union influence does; and (3) these effects are strongest among those regional international organizations that are based on founding contracts containing open-ended commitments. These findings indicate that the creation and subsequent institutional evolution of the European Union has made a difference to the evolution of institutions in regional international organizations elsewhere, thereby suggesting that existing theories of regionalism are insufficiently able to account for processes of institution building in such contexts.

Differentiation regional climate impact indicators at 1.5°C and 2°C warming above pre-industrial levels

NASA Astrophysics Data System (ADS)

Schleussner, C. F.

2016-12-01

Robust appraisals of climate impacts at different levels of global-mean temperature increase are vital to guide assessments of dangerous anthropogenic interference with the climate system. By establishing 1.5°C as the long term temperature limit for global average temperature increase and inviting a special report of the IPCC on the impacts of 1.5°C, the Paris Agreement has put such assessments high on the post-Paris science agenda. Here I will present recent findings of climate impacts at 1.5°C, including extreme weather events, water availability, agricultural yields, sea-level rise and risk of coral reef loss. In particular, I will present findings from a recent study that attempts to differentiate between such impacts at warming levels of 1.5°¸C and 2°C above pre-industrial (Schleussner et al., 2016). By analyzing changes in indicators for 26 world regions as applicable, the study found regional dependent differences between a 1.5°C and 2°C warming. Regional hot-spots of change emerge with tropical regions bearing the brunt of the impacts of an additional 0.5°C warming. These findings highlight the importance of regional differentiation to assess both future climate risks and different vulnerabilities to incremental increases in global-mean temperature. Building on that analysis, I will discuss limitations of existing approaches to differentiate between warming levels and outline opportunities for future work on refining our understanding of the difference between impacts at 1.5°C and 2°C warming. ReferencesSchleussner, C.-F. et al. Differential climate impacts for policy relevant limits to global warming: the case of 1.5°C and 2°C. Earth Syst. Dyn. 7, 327-351 (2016).

Anticipating and Understanding the Rebalance: Exercise Nine Innings, USMC Command and Staff College

DTIC Science & Technology

2017-06-21

USPACOM, professional military education , PME, Command and Staff College, training, education , Exercise Nine Innings, regional security challenges The...essence, professional military education had to keep up with the tempo of the evolution of warfare in the twenty-first century. Knowing and...operations existing in differing phases of execution, gained great- er interest among education commands, the Marine Corps, and joint leader- ship.4

Numerical simulation on casing modification of a boiler water circulation pump

NASA Astrophysics Data System (ADS)

Li, Y. Z.; Fan, Y. Z.; Liu, S. H.; Wu, Y. L.; Zuo, Z. G.

2012-11-01

In this paper, hydraulic performance comparisons are made by numerical simulation method on boiler water circulation pump with casings of different shapes. The existing pump adopts a semispherical casing and a garlic-shaped casing. Results show that in the garlic-shaped casing noticeable swirling vortex can be found in the top region of the discharge nozzle, and semispherical casing has better performance in hydraulic efficiency and head.

A Search for Giant Planet Companions to T Tauri Stars

DTIC Science & Technology

2012-12-20

yielded a spectral resolving power of R ≡ (λ/Δλ) ≈ 60,000. Integration times were typically 1800 s (depending on conditions) and typical seeing was∼2...wavelength regions. This suggests different physical mechanisms underlying the optical and the K-band variability. Key words: planets and satellites ...the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data

Large-eddy simulations of adverse pressure gradient turbulent boundary layers

NASA Astrophysics Data System (ADS)

Bobke, Alexandra; Vinuesa, Ricardo; Örlü, Ramis; Schlatter, Philipp

2016-04-01

Adverse pressure-gradient (APG) turbulent boundary layers (TBL) are studied by performing well-resolved large-eddy simulations. The pressure gradient is imposed by defining the free-stream velocity distribution with the description of a power law. Different inflow conditions, box sizes and upper boundary conditions are tested in order to determine the final set-up. The statistics of turbulent boundary layers with two different power-law coefficients and thus magnitudes of adverse pressure gradients are then compared to zero pressure-gradient (ZPG) data. The effect of the APG on TBLs is manifested in the mean flow through a much more prominent wake region and in the Reynolds stresses through the existence of an outer peak. The pre-multiplied energy budgets show that more energy is transported from the near-wall region to farther away from the wall.

Nonstationary oscillations in gyrotrons revisited

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dumbrajs, O., E-mail: olgerts.dumbrajs@lu.lv; Kalis, H., E-mail: harijs.kalis@lu.lv

2015-05-15

Development of gyrotrons requires careful understanding of different regimes of gyrotron oscillations. It is known that in the planes of the generalized gyrotron variables: cyclotron resonance mismatch and dimensionless current or cyclotron resonance mismatch and dimensionless interaction length complicated alternating sequences of regions of stationary, periodic, automodulation, and chaotic oscillations exist. In the past, these regions were investigated on the supposition that the transit time of electrons through the interaction space is much shorter than the cavity decay time. This assumption is valid for short and/or high diffraction quality resonators. However, in the case of long and/or low diffraction qualitymore » resonators, which are often utilized, this assumption is no longer valid. In such a case, a different mathematical formalism has to be used for studying nonstationary oscillations. One example of such a formalism is described in the present paper.« less

Characterization of two anti-dengue human monoclonal antibodies prepared from PBMCs of patients with dengue illness in Thailand.

PubMed

Li, Z-Y; Yamashita, A; Kawashita, N; Sasaki, T; Pan, Y; Ono, K-I; Ikuta, K; Li, Y-G

2016-06-01

The global spread of the four dengue virus (DENV) serotypes (dengue-1 to -4) has made this virus a major and growing public health concern. Generally, pre-existing neutralizing antibodies derived from primary infection play a significant role in protecting against subsequent infection with the same serotype. By contrast, these pre-existing antibodies are believed to mediate a non-protective response to subsequent heterotypic DENV infections, leading to the onset of dengue illness. In this study, two monoclonal antibodies prepared by using peripheral blood mononuclear cells (PBMCs) from patients with dengue fever were characterized. Epitope mapping revealed that amino acid residues 254-278 in domain II of the viral envelope protein E were the target region of these antibodies. A database search revealed that certain sequences in this epitope region showed high conservation among the four serotypes of DENV. These two human monoclonal antibodies could neutralize DENV-2,-4 more effectively than DENV-1,-3. The amino acid sequences could not explain this difference in neutralizing activity. However, the 3D structure results showed that amino acid 274 could be the critical residue for the difference in neutralization. These results may provide basic information for the development of a dengue vaccine.

Properties of material in the submillimeter wave region (instrumentation and measurement of index of refraction)

NASA Technical Reports Server (NTRS)

Lally, J.; Meister, R.

1983-01-01

The Properties of Materials in the Submillimeter Wave Region study was initiated to instrument a system and to make measurements of the complex index of refraction in the wavelength region between 0.1 to 1.0 millimeters. While refractive index data is available for a number of solids and liquids there still exists a need for an additional systematic study of dielectric properties to add to the existing data, to consider the accuracy of the existing data, and to extend measurements in this wavelength region for other selected mateials. The materials chosen for consideration would be those with useful thermal, mechanical, and electrical characteristics. The data is necessary for development of optical components which, for example, include beamsplitters, attenuators, lenses, grids, all useful for development of instrumentation in this relatively unexploited portion of the spectrum.

Regional- and local-scale variations in benthic megafaunal composition at the Arctic deep-sea observatory HAUSGARTEN

NASA Astrophysics Data System (ADS)

Taylor, J.; Krumpen, T.; Soltwedel, T.; Gutt, J.; Bergmann, M.

2016-02-01

The Long-Term Ecological Research (LTER) observatory HAUSGARTEN, in the eastern Fram Strait, provides us the valuable ability to study the composition of benthic megafaunal communities through the analysis of seafloor photographs. This, in combination with extensive sampling campaigns, which have yielded a unique data set on faunal, bacterial, biogeochemical and geological properties, as well as on hydrography and sedimentation patterns, allows us to address the question of why variations in megafaunal community structure and species distribution exist within regional (60-110 km) and local (<4 km) scales. Here, we present first results from the latitudinal HAUSGARTEN gradient, consisting of three different stations (N3, HG-IV, S3) between 78°30‧N and 79°45‧N (2351-2788 m depth), obtained via the analysis of images acquired by a towed camera (OFOS-Ocean Floor Observation System) in 2011. We assess variability in megafaunal densities, species composition and diversity as well as biotic and biogenic habitat features, which may cause the patterns observed. While there were significant regional-scale differences in megafaunal composition and densities between the stations (N3=26.74±0.63; HG-IV=11.21±0.25; S3=18.34±0.39 individuals m-2), significant local differences were only found at HG-IV. Regional-scale variations may be due to the significant differences in ice coverage at each station as well as the different quantities of protein available, whereas local-scale differences at HG-IV may be a result of variation in bottom topography or factors not yet identified.

Terminal Transient Phase of Chaotic Transients

NASA Astrophysics Data System (ADS)

Lilienkamp, Thomas; Parlitz, Ulrich

2018-03-01

Transient chaos in spatially extended systems can be characterized by the length of the transient phase, which typically grows quickly with the system size (supertransients). For a large class of these systems, the chaotic phase terminates abruptly, without any obvious precursors in commonly used observables. Here we investigate transient spatiotemporal chaos in two different models of this class. By probing the state space using perturbed trajectories we show the existence of a "terminal transient phase," which occurs prior to the abrupt collapse of chaotic dynamics. During this phase the impact of perturbations is significantly different from the earlier transient and particular patterns of (non)susceptible regions in state space occur close to the chaotic trajectories. We therefore hypothesize that even without perturbations proper precursors for the collapse of chaotic transients exist, which might be highly relevant for coping with spatiotemporal chaos in cardiac arrhythmias or brain functionality, for example.

Modulatory compartments in cortex and local regulation of cholinergic tone.

PubMed

Coppola, Jennifer J; Ward, Nicholas J; Jadi, Monika P; Disney, Anita A

2016-09-01

Neuromodulatory signaling is generally considered broad in its impact across cortex. However, variations in the characteristics of cortical circuits may introduce regionally-specific responses to diffuse modulatory signals. Features such as patterns of axonal innervation, tissue tortuosity and molecular diffusion, effectiveness of degradation pathways, subcellular receptor localization, and patterns of receptor expression can lead to local modification of modulatory inputs. We propose that modulatory compartments exist in cortex and can be defined by variation in structural features of local circuits. Further, we argue that these compartments are responsible for local regulation of neuromodulatory tone. For the cholinergic system, these modulatory compartments are regions of cortical tissue within which signaling conditions for acetylcholine are relatively uniform, but between which signaling can vary profoundly. In the visual system, evidence for the existence of compartments indicates that cholinergic modulation likely differs across the visual pathway. We argue that the existence of these compartments calls for thinking about cholinergic modulation in terms of finer-grained control of local cortical circuits than is implied by the traditional view of this system as a diffuse modulator. Further, an understanding of modulatory compartments provides an opportunity to better understand and perhaps correct signal modifications that lead to pathological states. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Formation and Maintenance of the Dominant Southern Polar Crown Cavity of Cycle 24

NASA Technical Reports Server (NTRS)

Karna, N.; Zhang, J.; Pesnell, W. D.

2017-01-01

In this article, we report a study of the longest-lived polar crown cavity of Solar Cycle 24, using an observation from 2013, and propose a physical mechanism to explain its sustained existence. We used high temporal and spatial resolution observations from the Atmospheric Imaging Assembly (AIA) and the Helioseismic Magnetic Imager (HMI) instruments on board the Solar Dynamics Observatory (SDO) to explore the structure and evolution of the cavity. Although it existed for more than a year, we examined the circumpolar cavity in great detail from 2013 March 21 to 2013 October 31. Our study reinforces the existing theory of formation of polar crown filaments that involves two basic processes to form any polar crown cavity as well as the long-lived cavity that we studied here. First, the underlying polarity inversion line (PIL) of the circumpolar cavity is formed between (1) the trailing part of dozens of decayed active regions distributed in different longitudes and (2) the unipolar magnetic field in the polar coronal hole. Second, the long life of the cavity is sustained by the continuing flux cancellation along the PIL. The flux is persistently transported toward the polar region through surface meridional flow and diffusion. The continuing flux cancellation leads to the shrinking of the polar coronal hole.

Cerebellar stem cells do not produce neurons and astrocytes in adult mouse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Xin; Guan, Wuqiang; Yu, Yong-Chun

Highlights: • No new neurons and astrocytes are generated in adult mouse cerebellum. • Very few mash1{sup +} or nestin{sup +} stem cells exist, and most of them are quiescent. • Cell proliferation rate is diversified among cerebellar regions and decreases over time. - Abstract: Although previous studies implied that cerebellar stem cells exist in some adult mammals, little is known about whether these stem cells can produce new neurons and astrocytes. In this study by bromodeoxyuridine (BrdU) intraperitoneal (i.p.) injection, we found that there are abundant BrdU{sup +} cells in adult mouse cerebellum, and their quantity and density decreasesmore » significantly over time. We also found cell proliferation rate is diversified in different cerebellar regions. Among these BrdU{sup +} cells, very few are mash1{sup +} or nestin{sup +} stem cells, and the vast majority of cerebellar stem cells are quiescent. Data obtained by in vivo retrovirus injection indicate that stem cells do not produce neurons and astrocytes in adult mouse cerebellum. Instead, some cells labeled by retrovirus are Iba1{sup +} microglia. These results indicate that very few stem cells exist in adult mouse cerebellum, and none of these stem cells contribute to neurogenesis and astrogenesis under physiological condition.« less

One Hundred Years of New York City's "Urban Heat Island": Temperature Trends and Public Health Impacts

NASA Astrophysics Data System (ADS)

Rosenthal, J. E.; Knowlton, K. M.; Rosenzweig, C.; Goldberg, R.; Kinney, P. L.

2003-12-01

In this paper, we examine the relationship between the historical development of New York City and its effect on the urban climate. Urban "heat islands" (UHI) are created principally by man-made surfaces, including concrete, dark roofs, asphalt lots and roads, which absorb most of the sunlight falling on them and reradiate that energy as heat. Many urban streets have fewer trees and other vegetation to shade buildings, block solar radiation and cool the air by evapotranspiration. The historical development of the NYC heat island effect was assessed in terms of average temperature differences of the city center relative to its surrounding 31-county metropolitan region, comprised of parts of New York State, New Jersey, and Connecticut. Monthly maximum and minimum temperatures for 1900-1997 were obtained from NOAA's National Climatic Data Center, the NASA-Goddard Institute for Space Studies, and the Lamont-Doherty Earth Observatory of Columbia University for 24 weather stations within the region that are part of the U.S. Historical Climatology Network. Analysis of annual mean temperatures shows an increasing difference between NYC (Central Park weather station) and its surrounding region over the twentieth century. Analysis of the temperature differences over time between NY Central Park (NYCP) station and 23 regional weather stations classified according to distance and level of urbanization show a heat island effect existing in NYC, with mean temperatures in the NYCP Station generally higher than the surrounding stations, ranging from 1.20\\deg C to 3.02\\deg C. A difference of at least 1\\deg C already existed at the beginning of the 20th century between the mean temperature in NYC and its surrounding rural areas, and this difference increased over the twentieth century. There was a significant decrease in the monthly and seasonal variability of the UHI effect over the century. Temperature extremes and summertime heat can create heat stress and other health consequences for urban residents. Public health impacts are assessed as the proportion of heat-related regional mortality estimated to be attributable to New York City's heat island effect during an average 1990's summer. Concentration-response functions describing the temperature-mortality relationship in NYC derived from the epidemiological literature are used to estimate numbers of deaths in a typical 1990s summer and those attributable to the city's heat island effect. The techniques and potential public health benefits of a pilot project to mitigate the heat island effect in NYC will be discussed.

Gender differences in regional cerebral activity during the perception of emotion: a functional MRI study.

PubMed

Hofer, Alex; Siedentopf, Christian M; Ischebeck, Anja; Rettenbacher, Maria A; Verius, Michael; Felber, Stephan; Fleischhacker, W Wolfgang

2006-08-15

Whether men activate different brain regions during various emotions compared to women or whether gender differences exist in transient emotional states has been the subject of only few studies. We used event-related functional magnetic resonance imaging (fMRI) to investigate gender differences during the perception of positive or negative emotions. The experiment comprised two emotional conditions (pleasant/unpleasant visual stimuli) during which fMRI data were acquired. Altogether, 38 healthy volunteers (19 males, 19 females) were investigated. When subtracting the activation values of men from those of women, suprathreshold positive signal changes were detected in the right posterior cingulate, the left putamen and the left cerebellum during positive mood induction, and in bilateral superior temporal gyri and cerebellar vermis during negative mood induction. The subtraction of activation values of women from those of men yielded no significant differences. Our findings suggest gender-related neural responses to emotional stimuli and could contribute to the understanding of mechanisms underlying gender-related vulnerability of the prevalence and severity of neuropsychiatric disorders.

Adipocyte Origins: Weighing the Possibilities

PubMed Central

Majka, Susan M.; Barak, Yaacov; Klemm, Dwight J.

2012-01-01

Adipose tissue is the primary energy reservoir in the body and an important endocrine organ that plays roles in energy homeostasis, feeding, insulin sensitivity and inflammation. While it was tacitly assumed that fat in different anatomical locations had a common origin and homogenous function, it is now clear that regional differences exist in adipose tissue characteristics and function. This is exemplified by the link between increased deep abdominal or visceral fat, but not peripheral adipose tissue, and the metabolic disturbances associated with obesity. Regional differences in fat function are due in large part to distinct adipocyte populations that comprise the different fat depots. Evidence accrued primarily in the last decade indicate that the distinct adipocyte populations are generated by a number of processes during and after development. These include the production of adipocytes from different germ cell layers, the formation of distinct preadipocyte populations from mesenchymal progenitors of mesodermal origin, and the production of adipocytes from hematopoietic stem cells from the bone marrow. This review will examine each of these process and their relevance to normal adipose tissue formation and contribution to obesity-related diseases. PMID:21544899

Breast cancer patients survival and associated factors: reported outcomes from the Southern Cancer Registry in Portugal.

PubMed

André, Maria Rosario; Amaral, Sandra; Mayer, Alexandra; Miranda, Ana

2014-01-01

Although the breast cancer incidence in Portugal is lower than the European average, it is the most frequent cancer in women. Overall, mortality rates are heterogeneous throughout Portugal. Implicated factors may include demographic and socioeconomic aspects, tumor biological characteristics, and access to medical care. The aim of this study is to detect survival differences in female breast cancer and identify the main associated factors. We have conducted a population-based, retrospective cohort study with follow-up. Incident breast cancer cases diagnosed in 2005 of residents in the southern region of Portugal were included. Data was collected from the Southern Portugal Cancer Registry (ROR-Sul) database and completed with clinical chart information. A total of 1 354 patients were included in this study. Observed geographical variations were as follows: for age distribution, with an aging population in Alentejo; for tumor sub-types, there was a higher incidence of HER2-positive tumors in the Algarve and a higher incidence of HER2-negative tumors in Região Autónoma da Madeira. Reported estimated 5-year overall survival was 80%, with significant association with tumor stage, hormone receptor and HER2 status. No survival differences were identified among women from distinct geographical regions. Although we found differences in age and tumor sub-type distribution between geographical regions, our study does not support the existence of discrepancies in breast cancer survival between these regions. Tumor biological characteristics seem to be the main associated factor with breast cancer survival in our population. Our study confirms the association between patient survival and tumor stage, hormone receptor and HER2 status. However, no differences in patient survival were observed among different regions of residence.

Seasonal and Regional Differences in Gene Expression in the Brain of a Hibernating Mammal

PubMed Central

Schwartz, Christine; Hampton, Marshall; Andrews, Matthew T.

2013-01-01

Mammalian hibernation presents a unique opportunity to study naturally occurring neuroprotection. Hibernating ground squirrels undergo rapid and extreme physiological changes in body temperature, oxygen consumption, and heart rate without suffering neurological damage from ischemia and reperfusion injury. Different brain regions show markedly different activity during the torpor/arousal cycle: the cerebral cortex shows activity only during the periodic returns to normothermia, while the hypothalamus is active over the entire temperature range. Therefore, region-specific neuroprotective strategies must exist to permit this compartmentalized spectrum of activity. In this study, we use the Illumina HiSeq platform to compare the transcriptomes of these two brain regions at four collection points across the hibernation season: April Active, October Active, Torpor, and IBA. In the cerebral cortex, 1,085 genes were found to be differentially expressed across collection points, while 1,063 genes were differentially expressed in the hypothalamus. Comparison of these transcripts indicates that the cerebral cortex and hypothalamus implement very different strategies during hibernation, showing less than 20% of these differentially expressed genes in common. The cerebral cortex transcriptome shows evidence of remodeling and plasticity during hibernation, including transcripts for the presynaptic cytomatrix proteins bassoon and piccolo, and extracellular matrix components, including laminins and collagens. Conversely, the hypothalamic transcriptome displays upregulation of transcripts involved in damage response signaling and protein turnover during hibernation, including the DNA damage repair gene RAD50 and ubiquitin E3 ligases UBR1 and UBR5. Additionally, the hypothalamus transcriptome also provides evidence of potential mechanisms underlying the hibernation phenotype, including feeding and satiety signaling, seasonal timing mechanisms, and fuel utilization. This study provides insight into potential neuroprotective strategies and hibernation control mechanisms, and also specifically shows that the hibernator brain exhibits both seasonal and regional differences in mRNA expression. PMID:23526982

Multiscale Detrended Cross-Correlation Analysis of STOCK Markets

NASA Astrophysics Data System (ADS)

Yin, Yi; Shang, Pengjian

2014-06-01

In this paper, we employ the detrended cross-correlation analysis (DCCA) to investigate the cross-correlations between different stock markets. We report the results of cross-correlated behaviors in US, Chinese and European stock markets in period 1997-2012 by using DCCA method. The DCCA shows the cross-correlated behaviors of intra-regional and inter-regional stock markets in the short and long term which display the similarities and differences of cross-correlated behaviors simply and roughly and the persistence of cross-correlated behaviors of fluctuations. Then, because of the limitation and inapplicability of DCCA method, we propose multiscale detrended cross-correlation analysis (MSDCCA) method to avoid "a priori" selecting the ranges of scales over which two coefficients of the classical DCCA method are identified, and employ MSDCCA to reanalyze these cross-correlations to exhibit some important details such as the existence and position of minimum, maximum and bimodal distribution which are lost if the scale structure is described by two coefficients only and essential differences and similarities in the scale structures of cross-correlation of intra-regional and inter-regional markets. More statistical characteristics of cross-correlation obtained by MSDCCA method help us to understand how two different stock markets influence each other and to analyze the influence from thus two inter-regional markets on the cross-correlation in detail, thus we get a richer and more detailed knowledge of the complex evolutions of dynamics of the cross-correlations between stock markets. The application of MSDCCA is important to promote our understanding of the internal mechanisms and structures of financial markets and helps to forecast the stock indices based on our current results demonstrated the cross-correlations between stock indices. We also discuss the MSDCCA methods of secant rolling window with different sizes and, lastly, provide some relevant implications and issue.

[Variability in the in-hospital management of acute myocardial infarction in Spain. IBERICA Study (Investigación, Búsqueda Específica y Registro de Isquemia Coronaria Aguda)].

PubMed

Fiol, M; Cabadés, A; Sala, J; Marrugat, J; Elosua, R; Vega, G; José Tormo Díaz, M; Segura, A; Aldasoro, E; Moreno-Iribas, C; Muñiz, J; Hurtado de Saracho, I; García, J

2001-04-01

Introduction and objective. Although some in-hospital studies have described the management of acute myocardial infarction (MI) patients in Spain, none has been able to guarantee the exhaustiveness of patient registry. This study sought to determine the clinical characteristics and in-hospital management of patients with MI in eight Spanish population registries.Methods. The IBERICA study is a population-based MI registry carried out in the 25 to 74 year-old population, in eight Spanish regions in 1997. A standardized methodology was used to register and investigate all MI arriving alive to a hospital. Clinical characteristics, cardiovascular risk factors prevalence, pharmacological treatment, invasive and non-invasive procedures performed and complications at 28 days of evolution were recorded. A descriptive analysis was performed and the variation coefficient (VC) was calculated.Results. In 1997, 4,041 MI patients were registered, 79.9% were men with a mean age of 61.1 years. Although 10.9% (95% CI: 9.9-11.9%) were not admitted to the coronary care unit, a large variability existed among different areas (VC = 53%). There was a high variability in the utilization and performance of non-invasive and invasive procedures among regions, as well as in the use of pharmacological treatment. Only the use of antiaggregants (91.5%) and thrombolytic therapy (41.8%) showed a low variability (VC < 10%). Twenty-eight day mortality was 16.2% (95% CI: 15.1-17.4%) with a high variability being observed among the different regions (VC = 20.6%).Conclusion. Patient characteristics vary among the different Spanish regions. The differences in management and prognosis suggest a lack of equality in the health care provided to MI patients in the different regions in Spain.

The relationship between HIV and fertility in the era of antiretroviral therapy in sub-Saharan Africa: evidence from 49 Demographic and Health Surveys.

PubMed

Marston, M; Zaba, B; Eaton, J W

2017-12-01

To describe regional differences in the relative fertility of HIV-positive vs. HIV-negative women and changes as antiretroviral treatment (ART) is scaled up, to improve estimates of predicted need for and coverage of prevention of mother-to-child transmission services at national and subnational levels. We analysed 49 nationally representative household surveys in sub-Saharan Africa between 2003 and 2016 to estimate fertility rate ratios of HIV-positive and HIV-negative women by age using exponential regression and test for regional and urban/rural differences. We estimated the association between national ART coverage and the relationship between HIV and fertility. Significant regional differences exist in HIV and fertility relationships, with less HIV-associated subfertility in Southern Africa. Age patterns of relative fertility are similar. HIV impact on fertility is weaker in urban than rural areas. For women below age 30, regional and urban/rural differences are largely explained by differences in age at sexual debut. Higher levels of national ART coverage were associated with slight attenuation of the relationship between HIV and fertility. Regional differences in HIV-associated subfertility and urban-rural differences in age patterns of relative fertility should be accounted for when predicting need for and coverage of PMTCT services at national and subnational level. Although HIV impacts on fertility are somewhat reduced at higher levels of national ART coverage, differences in fertility between HIV positive and negative remain, and fertility of women on ART should not be assumed to be the same as HIV-negative women. There were few data in recent years, when ART has reached high levels, and this relationship should continue to be assessed as further evidence becomes available. © 2017 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

Temporal and spatial water use on irrigated and nonirrigated pasture-based dairy farms.

PubMed

Higham, C D; Horne, D; Singh, R; Kuhn-Sherlock, B; Scarsbrook, M R

2017-08-01

Robust information for water use on pasture-based dairy farms is critical to farmers' attempts to use water more efficiently and the improved allocation of freshwater resources to dairy farmers. To quantify the water requirements of dairy farms across regions in a practicable manner, it will be necessary to develop predictive models. The objectives of this study were to compare water use on a group of irrigated and nonirrigated farms, validate existing water use models using the data measured on the group of nonirrigated farms, and modify the model so that it can be used to predict water use on irrigated dairy farms. Water use data were collected on a group of irrigated dairy farms located in the Canterbury, New Zealand, region with the largest area under irrigation. The nonirrigated farms were located in the Manawatu region. The amount of water used for irrigation was almost 52-fold greater than the amount of all other forms of water use combined. There were large differences in measured milking parlor water use, stock drinking water, and leakage rates between the irrigated and nonirrigated farms. As expected, stock drinking water was lower on irrigated dairy farms. Irrigation lowers the dry matter percentage of pasture, ensuring that the amount of water ingested from pasture remains high throughout the year, thereby reducing the demand for drinking water. Leakage rates were different between the 2 groups of farms; 47% of stock drinking water was lost as leakage on nonirrigated farms, whereas leakage on the irrigated farms equated to only 13% of stock drinking water. These differences in leakage were thought to be related to regional differences rather than differences in irrigated versus nonirrigated farms. Existing models developed to predict milking parlor, corrected stock drinking water, and total water use on nonirrigated pasture-based dairy farms in a previous related study were tested on the data measured in the present research. As expected, these models performed well for nonirrigated dairy farms but provided poor predictive power for irrigated farms. Partial least squares regression models were developed specifically to simulate corrected stock drinking water, milking parlor water, and total water use on irrigated dairy farms. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Hemispheric Asymmetry of Human Brain Anatomical Network Revealed by Diffusion Tensor Tractography

PubMed Central

Liu, Yaou; Duan, Yunyun; Li, Kuncheng

2015-01-01

The topological architecture of the cerebral anatomical network reflects the structural organization of the human brain. Recently, topological measures based on graph theory have provided new approaches for quantifying large-scale anatomical networks. However, few studies have investigated the hemispheric asymmetries of the human brain from the perspective of the network model, and little is known about the asymmetries of the connection patterns of brain regions, which may reflect the functional integration and interaction between different regions. Here, we utilized diffusion tensor imaging to construct binary anatomical networks for 72 right-handed healthy adult subjects. We established the existence of structural connections between any pair of the 90 cortical and subcortical regions using deterministic tractography. To investigate the hemispheric asymmetries of the brain, statistical analyses were performed to reveal the brain regions with significant differences between bilateral topological properties, such as degree of connectivity, characteristic path length, and betweenness centrality. Furthermore, local structural connections were also investigated to examine the local asymmetries of some specific white matter tracts. From the perspective of both the global and local connection patterns, we identified the brain regions with hemispheric asymmetries. Combined with the previous studies, we suggested that the topological asymmetries in the anatomical network may reflect the functional lateralization of the human brain. PMID:26539535

Ecological efficiency in China and its influencing factors-a super-efficient SBM metafrontier-Malmquist-Tobit model study.

PubMed

Ma, Xiaojun; Wang, Changxin; Yu, Yuanbo; Li, Yudong; Dong, Biying; Zhang, Xinyu; Niu, Xueqi; Yang, Qian; Chen, Ruimin; Li, Yifan; Gu, Yihan

2018-05-15

Ecological problem is one of the core issues that restrain China's economic development at present, and it is urgently needed to be solved properly and effectively. Based on panel data from 30 regions, this paper uses a super efficiency slack-based measure (SBM) model that introduces the undesirable output to calculate the ecological efficiency, and then uses traditional and metafrontier-Malmquist index method to study regional change trends and technology gap ratios (TGRs). Finally, the Tobit regression and principal component analysis methods are used to analysis the main factors affecting eco-efficiency and impact degree. The results show that about 60% of China's provinces have effective eco-efficiency, and the overall ecological efficiency of China is at the superior middling level, but there is a serious imbalance among different provinces and regions. Ecological efficiency has an obvious spatial cluster effect. There are differences among regional TGR values. Most regions show a downward trend and the phenomenon of focusing on economic development at the expense of ecological protection still exists. Expansion of opening to the outside, increases in R&D spending, and improvement of population urbanization rate have positive effects on eco-efficiency. Blind economic expansion, increases of industrial structure, and proportion of energy consumption have negative effects on eco-efficiency.

Cochlear partition tuning within the 2nd apical turn of the intact gerbil cochlea

NASA Astrophysics Data System (ADS)

Dong, Wei; Xia, Anping; Puria, Sunil; Applegate, Brian E.; Oghalai, John S.

2018-05-01

Our understanding of cochlear amplification has been mainly informed by observations of the high-frequency basal region. Results from the few existing in vivo studies from the low-frequency apical region have suggested that cochlear amplification may be more broadly tuned and not as nonlinear as in the base. The current study explored micromechanics via sound evoked vibrations of the cochlear partition, including the organ of Corti (OoC), the basilar membrane (BM) and the tectorial membrane (TM), within the 2nd apical turn, corresponding to the 2.5 kHz best frequency region, of the gerbil cochlea using volumetric optical coherence tomography vibrometry (VOCTV), imaged non-invasively through the otic capsule bone in vivo. Sound induced radial displacements below 4 kHz showed similarities and differences to the well-established BM transverse responses at high-frequency basal region. Responses showed broader tuning, but similar gains at the best frequency and similar phase accumulation. The distinct difference found was the presence of compressive nonlinear growth with SPL below the best frequency down to 0.1 kHz observed at the outer hair cell (OHC) and reticular laminar (RL) locations but not in the BM or inner hair cell regions. These relative motions provide further insight on how OHC somatic forces are distributed within the cochlear partition.

Is variation management included in regional healthcare governance systems? Some proposals from Italy.

PubMed

Nuti, Sabina; Seghieri, Chiara

2014-01-01

The Italian National Health System, which follows a Beveridge model, provides universal healthcare coverage through general taxation. Universal coverage provides uniform healthcare access to citizens and is the characteristic usually considered the added value of a welfare system financed by tax revenues. Nonetheless, wide differences in practice patterns, health outcomes and regional usages of resources that cannot be justified by differences in patient needs have been demonstrated to exist. Beginning with the experience of the health care system of the Tuscany region (Italy), this study describes the first steps of a long-term approach to proactively address the issue of geographic variation in healthcare. In particular, the study highlights how the unwarranted variation management has been addressed in a region with a high degree of managerial control over the delivery of health care and a consolidated performance evaluation system, by first, considering it a high priority objective and then by actively integrating it into the regional planning and control mechanism. The implications of this study can be useful to policy makers, professionals and managers, and will contribute to the understanding of how the management of variation can be implemented with performance measurements and financial incentives. Copyright © 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

An edge-centric perspective on the human connectome: link communities in the brain.

PubMed

de Reus, Marcel A; Saenger, Victor M; Kahn, René S; van den Heuvel, Martijn P

2014-10-05

Brain function depends on efficient processing and integration of information within a complex network of neural interactions, known as the connectome. An important aspect of connectome architecture is the existence of community structure, providing an anatomical basis for the occurrence of functional specialization. Typically, communities are defined as groups of densely connected network nodes, representing clusters of brain regions. Looking at the connectome from a different perspective, instead focusing on the interconnecting links or edges, we find that the white matter pathways between brain regions also exhibit community structure. Eleven link communities were identified: five spanning through the midline fissure, three through the left hemisphere and three through the right hemisphere. We show that these link communities are consistently identifiable and investigate the network characteristics of their underlying white matter pathways. Furthermore, examination of the relationship between link communities and brain regions revealed that the majority of brain regions participate in multiple link communities. In particular, the highly connected and central hub regions showed a rich level of community participation, supporting the notion that these hubs play a pivotal role as confluence zones in which neural information from different domains merges. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

9 CFR 93.201 - General prohibitions; exceptions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the United States if the poultry have been vaccinated for the H5 or H7 subtype of avian influenza. 2... been in any region where highly pathogenic avian influenza exists, which are subject to the provisions... region where highly pathogenic avian influenza exists may only be imported through the port of Los...

9 CFR 93.201 - General prohibitions; exceptions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the United States if the poultry have been vaccinated for the H5 or H7 subtype of avian influenza. 2... been in any region where highly pathogenic avian influenza exists, which are subject to the provisions... region where highly pathogenic avian influenza exists may only be imported through the port of Los...

9 CFR 93.201 - General prohibitions; exceptions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the United States if the poultry have been vaccinated for the H5 or H7 subtype of avian influenza. 2... been in any region where highly pathogenic avian influenza exists, which are subject to the provisions... region where highly pathogenic avian influenza exists may only be imported through the port of Los...

9 CFR 94.10 - Swine from regions where classical swine fever exists.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Swine from regions where classical swine fever exists. 94.10 Section 94.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... PRODUCTS RINDERPEST, FOOT-AND-MOUTH DISEASE, EXOTIC NEWCASTLE DISEASE, AFRICAN SWINE FEVER, CLASSICAL SWINE...

9 CFR 94.10 - Swine from regions where classical swine fever exists.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Swine from regions where classical swine fever exists. 94.10 Section 94.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... PRODUCTS RINDERPEST, FOOT-AND-MOUTH DISEASE, EXOTIC NEWCASTLE DISEASE, AFRICAN SWINE FEVER, CLASSICAL SWINE...

An outlook for sustainable forest bioenergy production in the Lake States

Treesearch

Dennis R. Becker; Kenneth Skog; Allison Hellman; Kathleen E. Halvorsen; Terry Mace

2009-01-01

The Lake States region of Minnesota, Wisconsin and Michigan offers significant potential for bioenergy production. We examine the sustainability of regional forest biomass use in the context of existing thermal heating, electricity, and biofuels production, projected resource needs over the next decade including existing forest product market demand, and impacts on...

Desorption of micropollutant from spent carbon filters used for water purifier.

PubMed

Kwon, Da-Sol; Tak, So-Yeon; Lee, Jung-Eun; Kim, Moon-Kyung; Lee, Young Hwa; Han, Doo Won; Kang, Sanghyeon; Zoh, Kyung-Duk

2017-07-01

In this study, to examine the accumulated micropollutants in the spent carbon filter used in the water purifier, first, the method to desorb micropollutant from the activated carbon was developed and optimized. Then, using this optimized desorption conditions, we examined which micropollutants exist in spent carbon filters collected from houses in different regions in Korea where water purifiers were used. A total of 11 micropollutants (caffeine (CFF), acetaminophen (ACT), sulfamethazine (SMA), sulfamethoxazole (SMZ), metoprolol (MTP), carbamazepine (CBM), naproxen (NPX), bisphenol-A (BPA), ibuprofen (IBU), diclofenac (DCF), and triclocarban (TCB)) were analyzed using LC/MS-MS from the spent carbon filters. CFF, NPX, and DCF had the highest detection frequencies (>60%) in the carbon filters (n = 100), whereas SMA, SMZ, and MTP were only detected in the carbon filters, but not in the tap waters (n = 25), indicating that these micropollutants, which exist less than the detection limit in tap water, were accumulated in the carbon filters. The regional micropollutant detection patterns in the carbon filters showed higher levels of micropollutants, especially NPX, BPA, IBU, and DCF, in carbon filters collected in the Han River and Nakdong River basins where large cities exist. The levels of micropollutants in the carbon filter were generally lower in the regions where advanced oxidation processes (AOPs) were employed at nearby water treatment plants (WTPs), indicating that AOP process in WTP is quite effective in removing micropollutant. Our results suggest that desorption of micropollutant from the carbon filter used can be a tool to identify micropollutants present in tap water with trace amounts or below the detection limit.

Sex in the brain: hormones and sex differences.

PubMed

Marrocco, Jordan; McEwen, Bruce S

2016-12-01

Contrary to popular belief, sex hormones act throughout the entire brain of both males and females via both genomic and nongenomic receptors. Many neural and behavioral functions are affected by estrogens, including mood, cognitive function, blood pressure regulation, motor coordination, pain, and opioid sensitivity. Subtle sex differences exist for many of these functions that are developmentally programmed by hormones and by not yet precisely defined genetic factors, including the mitochondrial genome. These sex differences, and responses to sex hormones in brain regions and upon functions not previously regarded as subject to such differences, indicate that we are entering a new era in our ability to understand and appreciate the diversity of gender-related behaviors and brain functions.

Regional bankfull geometry relationships for southern California mountain streams and hydrologic applications

NASA Astrophysics Data System (ADS)

Modrick, Theresa M.; Georgakakos, Konstantine P.

2014-09-01

This study develops and intercompares regional relationships for bankfull channel width, hydraulic depth, and cross-sectional area for southern California mountain streams based on several data sources: surveyed streams, US Geological Survey stream survey reports, and existing literature. Although considerable uncertainty exists in estimating bankfull conditions, the relationships developed from the varying data sources show significant agreement. For small watersheds with drainage area ranging from 15 to ~ 2000 km2, the estimates of bankfull top width ranged from 7.2 to 44.5 m and hydraulic depth estimates ranged from 0.35 to 1.15 m. The utility of the developed bankfull geometry regional curves is demonstrated for southern California catchments through (a) the computation of the bankfull discharge and (b) the estimation of the surface runoff response necessary to produce bankfull conditions in the streams at the outlet of these catchments. For selected locations with instantaneous flow records, the occurrence frequency of events exceeding bankfull flow was examined for the available 10-15 year span of observational records. Bankfull discharge estimates for all small watersheds in the region ranged from 1.3 to 74 m3/s, while the range at the selected gauged stream locations was from 2.6 to 16.4 m3/s. Stream locations along the Transverse Mountains of southern California showed an average occurrence frequency of less than 1 year, whereas along the Peninsular Mountains the average return period tended to be greater than 1 year. The application of the regional curves to the estimation of the surface runoff response necessary to produce bankfull conditions at the channel outlets of small catchments may be used as an index for conditions of minor flooding with saturated soils. This surface runoff response index ranges from 2.0 to 5.5 mm for a 3-hour rainfall duration for southern California watersheds greater than 15 km2 in area. Differences between the values for the Peninsular and Transverse Mountain Ranges are linked to geological, climatic, and geomorphologic differences. The developed regional geometry relationships are suitable for use in various hydrologic modeling applications, including distributed modeling with high resolution pertinent to flash flood forecasting.

Seismic imaging using finite-differences and parallel computers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ober, C.C.

1997-12-31

A key to reducing the risks and costs of associated with oil and gas exploration is the fast, accurate imaging of complex geologies, such as salt domes in the Gulf of Mexico and overthrust regions in US onshore regions. Prestack depth migration generally yields the most accurate images, and one approach to this is to solve the scalar wave equation using finite differences. As part of an ongoing ACTI project funded by the US Department of Energy, a finite difference, 3-D prestack, depth migration code has been developed. The goal of this work is to demonstrate that massively parallel computersmore » can be used efficiently for seismic imaging, and that sufficient computing power exists (or soon will exist) to make finite difference, prestack, depth migration practical for oil and gas exploration. Several problems had to be addressed to get an efficient code for the Intel Paragon. These include efficient I/O, efficient parallel tridiagonal solves, and high single-node performance. Furthermore, to provide portable code the author has been restricted to the use of high-level programming languages (C and Fortran) and interprocessor communications using MPI. He has been using the SUNMOS operating system, which has affected many of his programming decisions. He will present images created from two verification datasets (the Marmousi Model and the SEG/EAEG 3D Salt Model). Also, he will show recent images from real datasets, and point out locations of improved imaging. Finally, he will discuss areas of current research which will hopefully improve the image quality and reduce computational costs.« less

Optimal environmental management strategy and implementation for groundwater contamination prevention and restoration.

PubMed

Wang, Mingyu

2006-04-01

An innovative management strategy is proposed for optimized and integrated environmental management for regional or national groundwater contamination prevention and restoration allied with consideration of sustainable development. This management strategy accounts for availability of limited resources, human health and ecological risks from groundwater contamination, costs for groundwater protection measures, beneficial uses and values from groundwater protection, and sustainable development. Six different categories of costs are identified with regard to groundwater prevention and restoration. In addition, different environmental impacts from groundwater contamination including human health and ecological risks are individually taken into account. System optimization principles are implemented to accomplish decision-makings on the optimal resources allocations of the available resources or budgets to different existing contaminated sites and projected contamination sites for a maximal risk reduction. Established management constraints such as budget limitations under different categories of costs are satisfied at the optimal solution. A stepwise optimization process is proposed in which the first step is to select optimally a limited number of sites where remediation or prevention measures will be taken, from all the existing contaminated and projected contamination sites, based on a total regionally or nationally available budget in a certain time frame such as 10 years. Then, several optimization steps determined year-by-year optimal distributions of the available yearly budgets for those selected sites. A hypothetical case study is presented to demonstrate a practical implementation of the management strategy. Several issues pertaining to groundwater contamination exposure and risk assessments and remediation cost evaluations are briefly discussed for adequately understanding implementations of the management strategy.

Mobile phone tools for field-based health care workers in low-income countries.

PubMed

Derenzi, Brian; Borriello, Gaetano; Jackson, Jonathan; Kumar, Vikram S; Parikh, Tapan S; Virk, Pushwaz; Lesh, Neal

2011-01-01

In low-income regions, mobile phone-based tools can improve the scope and efficiency of field health workers. They can also address challenges in monitoring and supervising a large number of geographically distributed health workers. Several tools have been built and deployed in the field, but little comparison has been done to help understand their effectiveness. This is largely because no framework exists in which to analyze the different ways in which the tools help strengthen existing health systems. In this article we highlight 6 key functions that health systems currently perform where mobile tools can provide the most benefit. Using these 6 health system functions, we compare existing applications for community health workers, an important class of field health workers who use these technologies, and discuss common challenges and lessons learned about deploying mobile tools. © 2011 Mount Sinai School of Medicine.

Implementing a regional oncology information system: approach and lessons learned.

PubMed

Evans, W K; Ashbury, F D; Hogue, G L; Smith, A; Pun, J

2014-10-01

Paper-based medical record systems are known to have major problems of inaccuracy, incomplete data, poor accessibility, and challenges to patient confidentiality. They are also an inefficient mechanism of record-sharing for interdisciplinary patient assessment and management, and represent a major problem for keeping current and monitoring quality control to facilitate improvement. To address those concerns, national, regional, and local health care authorities have increased the pressure on oncology practices to upgrade from paper-based systems to electronic health records. Here, we describe and discuss the challenges to implementing a region-wide oncology information system across four independent health care organizations, and we describe the lessons learned from the initial phases that are now being applied in subsequent activities of this complex project. The need for change must be shared across centres to increase buy-in, adoption, and implementation. It is essential to establish physician leadership, commitment, and engagement in the process. Work processes had to be revised to optimize use of the new system. Culture change must be included in the change management strategy. Furthermore, training and resource requirements must be thoroughly planned, implemented, monitored, and modified as required for effective adoption of new work processes and technology. Interfaces must be established with multiple existing electronic systems across the region to ensure appropriate patient flow. Periodic assessment of the existing project structure is necessary, and adjustments are often required to ensure that the project meets its objectives. The implementation of region-wide oncology information systems across different health practice locations has many challenges. Leadership is essential. A strong, collaborative information-sharing strategy across the region and with the supplier is essential to identify, discuss, and resolve implementation problems. A structure that supports project management and accountability contributes to success.

Probe-specific mixed-model approach to detect copy number differences using multiplex ligation-dependent probe amplification (MLPA)

PubMed Central

González, Juan R; Carrasco, Josep L; Armengol, Lluís; Villatoro, Sergi; Jover, Lluís; Yasui, Yutaka; Estivill, Xavier

2008-01-01

Background MLPA method is a potentially useful semi-quantitative method to detect copy number alterations in targeted regions. In this paper, we propose a method for the normalization procedure based on a non-linear mixed-model, as well as a new approach for determining the statistical significance of altered probes based on linear mixed-model. This method establishes a threshold by using different tolerance intervals that accommodates the specific random error variability observed in each test sample. Results Through simulation studies we have shown that our proposed method outperforms two existing methods that are based on simple threshold rules or iterative regression. We have illustrated the method using a controlled MLPA assay in which targeted regions are variable in copy number in individuals suffering from different disorders such as Prader-Willi, DiGeorge or Autism showing the best performace. Conclusion Using the proposed mixed-model, we are able to determine thresholds to decide whether a region is altered. These threholds are specific for each individual, incorporating experimental variability, resulting in improved sensitivity and specificity as the examples with real data have revealed. PMID:18522760

Prevalence and predictors of postoperative pain after ear, nose, and throat surgery.

PubMed

Sommer, Michael; Geurts, José W J M; Stessel, Bjorn; Kessels, Alfons G H; Peters, Madelon L; Patijn, Jacob; van Kleef, Maarten; Kremer, Bernd; Marcus, Marco A E

2009-02-01

To determine postoperative pain in different types of ear, nose, and throat (ENT) surgery and their psychological preoperative predictors. Prospective cohort study. Academic hospital. A total of 217 patients undergoing ENT surgery. All ENT, neck, and salivary gland surgery. Postoperative pain and predictors for postoperative pain. Fifty percent of the patients undergoing surgery on the oral, pharyngeal, and laryngeal region and on the neck and salivary gland region had a visual analog scale score higher than 40 mm on day 1. In the patients who underwent oropharyngeal region operations the VAS score remained high on all 4 days. A VAS pain score higher than 40 mm was found in less than 30% of patients after endoscopic procedures and less than 20% after ear and nose surgery. After bivariate analysis, 6 variables--age, sex, preoperative pain, expected pain, short-term fear, and pain catastrophizing--had a predictive value. Multivariate analysis showed only preoperative pain, pain catastrophizing, and anatomical site of operation as independent predictors. Differences exist in the prevalence of unacceptable postoperative pain between ENT operations performed on different anatomical sites. A limited set of variables can be used to predict the occurrence of unacceptable postoperative pain after ENT surgery.

Biomechanically based simulation of brain deformations for intraoperative image correction: coupling of elastic and fluid models

NASA Astrophysics Data System (ADS)

Hagemann, Alexander; Rohr, Karl; Stiehl, H. Siegfried

2000-06-01

In order to improve the accuracy of image-guided neurosurgery, different biomechanical models have been developed to correct preoperative images w.r.t. intraoperative changes like brain shift or tumor resection. All existing biomechanical models simulate different anatomical structures by using either appropriate boundary conditions or by spatially varying material parameter values, while assuming the same physical model for all anatomical structures. In general, this leads to physically implausible results, especially in the case of adjacent elastic and fluid structures. Therefore, we propose a new approach which allows to couple different physical models. In our case, we simulate rigid, elastic, and fluid regions by using the appropriate physical description for each material, namely either the Navier equation or the Stokes equation. To solve the resulting differential equations, we derive a linear matrix system for each region by applying the finite element method (FEM). Thereafter, the linear matrix systems are linked together, ending up with one overall linear matrix system. Our approach has been tested using synthetic as well as tomographic images. It turns out from experiments, that the integrated treatment of rigid, elastic, and fluid regions significantly improves the prediction results in comparison to a pure linear elastic model.

Evidence for coherent spicule oscillations from correcting Hinode/SOT Ca II H in the south-east limb of the Sun

NASA Astrophysics Data System (ADS)

Ahangarzadeh Maralani, A. R.; Tavabi, E.; Ajabshirizadeh, A.

2017-05-01

Wave theories of heating of the chromosphere, corona and solar wind due to photospheric fluctuations are strengthened by the existence of the wave coherency observed up to the transition region. The coherency of intensity oscillations of solar spicules was explored using the Solar Optical Telescope (SOT) on the Hinode spacecraft with increasing height above the solar limb in the active region. We used time sequences near the south-east region from the Hinode/SOT for the Ca II H line obtained on 2015 April 3 and applied the de-convolution procedure to the spicule to illustrate how effectively our restoration method works on fine structures such as spicules. Moreover, the intensity oscillations at different heights above the solar limb were analysed through wavelet transforms. Afterwards, the phase difference was measured between oscillations at two heights in search of evidence for coherent oscillations. The results of the wavelet transformations revealed dominant period peaks for 2, 4, 5.5 and 6.5 min at four separate heights. The dominant frequencies for a coherency level higher than 75 per cent were found to be around 5.5 and 8.5 mHz. Mean phase speeds of 155-360 km s-1 were measured. We found that the mean phase speeds increased with height. The results suggest that the energy flux carried by coherent waves into the corona and heliosphere may be several times larger than previous estimates that were based solely on constant velocities. We provide compelling evidence for the existence of upwardly propagating coherent waves.

A new concept in seismic landslide hazard analysis for practical application

NASA Astrophysics Data System (ADS)

Lee, Chyi-Tyi

2017-04-01

A seismic landslide hazard model could be constructed using deterministic approach (Jibson et al., 2000) or statistical approach (Lee, 2014). Both approaches got landslide spatial probability under a certain return-period earthquake. In the statistical approach, our recent study found that there are common patterns among different landslide susceptibility models of the same region. The common susceptibility could reflect relative stability of slopes at a region; higher susceptibility indicates lower stability. Using the common susceptibility together with an earthquake event landslide inventory and a map of topographically corrected Arias intensity, we can build the relationship among probability of failure, Arias intensity and the susceptibility. This relationship can immediately be used to construct a seismic landslide hazard map for the region that the empirical relationship built. If the common susceptibility model is further normalized and the empirical relationship built with normalized susceptibility, then the empirical relationship may be practically applied to different region with similar tectonic environments and climate conditions. This could be feasible, when a region has no existing earthquake-induce landslide data to train the susceptibility model and to build the relationship. It is worth mentioning that a rain-induced landslide susceptibility model has common pattern similar to earthquake-induced landslide susceptibility in the same region, and is usable to build the relationship with an earthquake event landslide inventory and a map of Arias intensity. These will be introduced with examples in the meeting.

Assessing climate change impacts on the rape stem weevil, Ceutorhynchus napi Gyll., based on bias- and non-bias-corrected regional climate change projections.

PubMed

Junk, J; Ulber, B; Vidal, S; Eickermann, M

2015-11-01

Agricultural production is directly affected by projected increases in air temperature and changes in precipitation. A multi-model ensemble of regional climate change projections indicated shifts towards higher air temperatures and changing precipitation patterns during the summer and winter seasons up to the year 2100 for the region of Goettingen (Lower Saxony, Germany). A second major controlling factor of the agricultural production is the infestation level by pests. Based on long-term field surveys and meteorological observations, a calibration of an existing model describing the migration of the pest insect Ceutorhynchus napi was possible. To assess the impacts of climate on pests under projected changing environmental conditions, we combined the results of regional climate models with the phenological model to describe the crop invasion of this species. In order to reduce systematic differences between the output of the regional climate models and observational data sets, two different bias correction methods were applied: a linear correction for air temperature and a quantile mapping approach for precipitation. Only the results derived from the bias-corrected output of the regional climate models showed satisfying results. An earlier onset, as well as a prolongation of the possible time window for the immigration of Ceutorhynchus napi, was projected by the majority of the ensemble members.

Assessing climate change impacts on the rape stem weevil, Ceutorhynchus napi Gyll., based on bias- and non-bias-corrected regional climate change projections

NASA Astrophysics Data System (ADS)

Junk, J.; Ulber, B.; Vidal, S.; Eickermann, M.

2015-11-01

Agricultural production is directly affected by projected increases in air temperature and changes in precipitation. A multi-model ensemble of regional climate change projections indicated shifts towards higher air temperatures and changing precipitation patterns during the summer and winter seasons up to the year 2100 for the region of Goettingen (Lower Saxony, Germany). A second major controlling factor of the agricultural production is the infestation level by pests. Based on long-term field surveys and meteorological observations, a calibration of an existing model describing the migration of the pest insect Ceutorhynchus napi was possible. To assess the impacts of climate on pests under projected changing environmental conditions, we combined the results of regional climate models with the phenological model to describe the crop invasion of this species. In order to reduce systematic differences between the output of the regional climate models and observational data sets, two different bias correction methods were applied: a linear correction for air temperature and a quantile mapping approach for precipitation. Only the results derived from the bias-corrected output of the regional climate models showed satisfying results. An earlier onset, as well as a prolongation of the possible time window for the immigration of Ceutorhynchus napi, was projected by the majority of the ensemble members.

Health disparities among the western, central and eastern rural regions of China after a decade of health promotion and disease prevention programming.

PubMed

Zhang, Xi-Fan; Tian, Xiang-Yang; Cheng, Yu-Lan; Feng, Zhan-Chun; Wang, Liang; Southerland, Jodi

2015-08-01

Health disparities between the western, central and eastern regions of rural China, and the impact of national health improvement policies and programming were assessed. A total of 400 counties were randomly sampled. ANOVA and Logistic regression modeling were employed to estimate differences in health outcomes and determinants. Significant differences were found between the western, central and eastern rural regions in community infrastructure and health outcomes. From 2000 to 2010, health indicators in rural China were improved significantly, and the infant mortality rate (IMR), maternal mortality rate (MMR) and under 5 mortality rate (U5MR) had fallen by 62.79%, 71.74% and 61.92%, respectively. Central rural China had the greatest decrease in IMR (65.05%); whereas, western rural China had the greatest reduction in MMR (72.99%) but smallest reduction in U5MR (57.36%). Despite these improvements, Logistic regression analysis showed regional differences in key health outcome indicators (odds ratios): IMR (central: 2.13; western: 5.31), U5MR (central: 2.25; western: 5.69), MMR (central: 1.94; western: 3.31), and prevalence of infectious diseases (central: 1.62; western: 3.58). The community infrastructure and health outcomes of the western and central rural regions of China have been improved markedly during the first decade of the 21st century. However, health disparities still exist across the three regions. National efforts to increase per capita income, community empowerment and mobilization, community infrastructure, capacity of rural health facilities, and health literacy would be effective policy options to attain health equity.

An ethnobotanical survey of medicinal plants used in the East Sepik province of Papua New Guinea.

PubMed

Koch, Michael; Kehop, Dickson Andrew; Kinminja, Boniface; Sabak, Malcolm; Wavimbukie, Graham; Barrows, Katherine M; Matainaho, Teatulohi K; Barrows, Louis R; Rai, Prem P

2015-11-14

Rapid modernization in the East Sepik (ES) Province of Papua New Guinea (PNG) is resulting in a decrease in individuals knowledgeable in medicinal plant use. Here we report a synthesis and comparison of traditional medicinal plant use from four ethnically distinct locations in the ES Province and furthermore compare them to two other previous reports of traditional plant use from different provinces of PNG. This manuscript is based on an annotated combination of four Traditional Medicines (TM) survey reports generated by University of Papua New Guinea (UPNG) trainees. The surveys utilized a questionnaire titled "Information sheet on traditional herbal preparations and medicinal plants of PNG", administered in the context of the TM survey project which is supported by WHO, US NIH and PNG governmental health care initiatives and funding. Regional and transregional comparison of medicinal plant utilization was facilitated by using existing plant databases: the UPNG TM Database and the PNG Plant Database (PNG Plants) using Bayesian statistical analysis. Medicinal plant use between four distinct dialect study areas in the ES Province of PNG showed that only a small fraction of plants had shared use in each area, however usually utilizing different plant parts, being prepared differently and to treat different medical conditions. Several instances of previously unreported medicinal plants could be located. Medicinally under- and over-utilized plants were found both in the regional reports and in a transregional analysis, thus showing that these medicinal utilization frequencies differ between provinces. Documentation of consistent plant use argues for efficacy and is particularly important since established and effective herbal medicinal interventions are sorely needed in the rural areas of PNG, and unfortunately clinical validation for the same is often lacking. Despite the existence of a large corpus of medical annotation of plants for PNG, previously unknown medical uses of plants can be uncovered. Furthermore, comparisons of medicinal plant utilization is possible if databases are reformatted for consistencies that allow comparisons. A concerted effort in building easily comparable databases could dramatically facilitate ethnopharmacological analysis of the existing plant diversity.

Hadron and Photon Production of J Particles and the Origin of J Particles

DOE R&D Accomplishments Database

Ting, S. C. C.

1975-01-01

There have been many theoretical speculations on the existence of long lived neutral particles with a mass larger than 10 GeV/c{sup 2} which play the role of weak interactions that photons play in electromagnetic interactions. There is, however, no theoretical justification, and no predictions exist, for long lived particles in the mass region 1-10 GeV/{up 2}. Even though there is no strong theoretical justification for the existence of long lived particles at low masses, there is no experimental indication that they should not exist. Until last year no high sensitivity experiment had been done in this mass region.

Facies analysis of Tertiary basin-filling rocks of the Death Valley regional ground-water system and surrounding areas, Nevada and California

USGS Publications Warehouse

Sweetkind, Donald S.; Fridrich, Christopher J.; Taylor, Emily

2001-01-01

Existing hydrologic models of the Death Valley region typically have defined the Cenozoic basins as those areas that are covered by recent surficial deposits, and have treated the basin-fill deposits that are concealed under alluvium as a single unit with uniform hydrologic properties throughout the region, and with depth. Although this latter generalization was known to be flawed, it evidently was made because available geologic syntheses did not provide the basis for a more detailed characterization. As an initial attempt to address this problem, this report presents a compilation and synthesis of existing and new surface and subsurface data on the lithologic variations between and within the Cenozoic basin fills of this region. The most permeable lithologies in the Cenozoic basin fills are freshwater limestones, unaltered densely welded tuffs, and little-consolidated coarse alluvium. The least permeable lithologies are playa claystones, altered nonwelded tuffs, and tuffaceous and clay-matrix sediments of several types. In all but the youngest of the basin fills, permeability probably decreases strongly with depth owing to a typically increasing abundance of volcanic ash or clay in the matrices of the clastic sediments with increasing age (and therefore with increasing depth in general), and to increasing consolidation and alteration (both hydrothermal and diagenetic) with increasing depth and age. This report concludes with a categorization of the Cenozoic basins of the Death Valley region according to the predominant lithologies in the different basin fills and presents qualitative constraints on the hydrologic properties of these major lithologic categories.

Subseasonal forecast skills and biases of global summer monsoons in the NCEP Climate Forecast System version 2

NASA Astrophysics Data System (ADS)

Liu, Xiangwen; Yang, Song; Li, Qiaoping; Kumar, Arun; Weaver, Scott; Liu, Shi

2014-03-01

Subseasonal forecast skills and biases of global summer monsoons are diagnosed using daily data from the hindcasts of 45-day integrations by the NCEP Climate Forecast System version 2. Predictions for subseasonal variability of zonal wind and precipitation are generally more skillful over the Asian and Australian monsoon regions than other monsoon regions. Climatologically, forecasts for the variations of dynamical monsoon indices have high skills at leads of about 2 weeks. However, apparent interannual differences exist, with high skills up to 5 weeks in exceptional cases. Comparisons for the relationships of monsoon indices with atmospheric circulation and precipitation patterns between skillful and unskillful forecasts indicate that skills for subseasonal variability of a monsoon index depend partially on the degree to which the observed variability of the index attributes to the variation of large-scale circulation. Thus, predictions are often more skillful when the index is closely linked to atmospheric circulation over a broad region than over a regional and narrow range. It is also revealed that, the subseasonal variations of biases of winds, precipitation, and surface temperature over various monsoon regions are captured by a first mode with seasonally independent biases and a second mode with apparent phase transition of biases during summer. The first mode indicates the dominance of overall weaker-than-observed summer monsoons over major monsoon regions. However, at certain stages of monsoon evolution, these underestimations are regionally offset or intensified by the time evolving biases portrayed by the second mode. This feature may be partially related to factors such as the shifts of subtropical highs and intertropical convergence zones, the reversal of biases of surface temperature over some monsoon regions, and the transition of regional circulation system. The significant geographical differences in bias growth with increasing lead time reflect the distinctions of initial memory capability of the climate system over different monsoon regions.

Independent variable complexity for regional regression of the flow duration curve in ungauged basins

NASA Astrophysics Data System (ADS)

Fouad, Geoffrey; Skupin, André; Hope, Allen

2016-04-01

The flow duration curve (FDC) is one of the most widely used tools to quantify streamflow. Its percentile flows are often required for water resource applications, but these values must be predicted for ungauged basins with insufficient or no streamflow data. Regional regression is a commonly used approach for predicting percentile flows that involves identifying hydrologic regions and calibrating regression models to each region. The independent variables used to describe the physiographic and climatic setting of the basins are a critical component of regional regression, yet few studies have investigated their effect on resulting predictions. In this study, the complexity of the independent variables needed for regional regression is investigated. Different levels of variable complexity are applied for a regional regression consisting of 918 basins in the US. Both the hydrologic regions and regression models are determined according to the different sets of variables, and the accuracy of resulting predictions is assessed. The different sets of variables include (1) a simple set of three variables strongly tied to the FDC (mean annual precipitation, potential evapotranspiration, and baseflow index), (2) a traditional set of variables describing the average physiographic and climatic conditions of the basins, and (3) a more complex set of variables extending the traditional variables to include statistics describing the distribution of physiographic data and temporal components of climatic data. The latter set of variables is not typically used in regional regression, and is evaluated for its potential to predict percentile flows. The simplest set of only three variables performed similarly to the other more complex sets of variables. Traditional variables used to describe climate, topography, and soil offered little more to the predictions, and the experimental set of variables describing the distribution of basin data in more detail did not improve predictions. These results are largely reflective of cross-correlation existing in hydrologic datasets, and highlight the limited predictive power of many traditionally used variables for regional regression. A parsimonious approach including fewer variables chosen based on their connection to streamflow may be more efficient than a data mining approach including many different variables. Future regional regression studies may benefit from having a hydrologic rationale for including different variables and attempting to create new variables related to streamflow.

Physical oceanography of continental shelves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, J.S.; Beardlsey, R.C.; Blanton, J.O.

Knowledge of the physical oceanography of continental shelves has increased tremendously in recent years, primarily as a result of new current and hydrographic measurements made in locations where no comparable measurements existed previously. In general, observations from geographically distinct continental shelves have shown that the nature of the flow may vary considerably from region to region. Although some characteristics, such as the response of currents to wind forcing, are common to many shelves, the relative importance of various physical processes in influencing the shelf flow field frequently is different. In the last several years, the scientific literature on shelf studiesmore » has expanded rapidly, with that for separate regions, to some extent, developing independently because of the variable role played by different physical effects. Consequently, it seems that a simultaneous review of progress in physical oceanographic research in different shelf regions would be especially useful at this time in order to help assess the overall progress in the field. This multi-author report has been compiled as a result. Included are sections on the physical oceanography of continental shelves, in or off of, the eastern Bering Sea, northern Gulf of Alaska, Pacific Northwest, southern California, west Florida, southeastern US, Middle Atlantic Bight, Georges Bank and Peru. These discussions clearly point to the diverse nature of the dominant physics in several of the regions, as well as to some of the dynamical features they share in common. 390 references, 23 figures.« less

Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related.

PubMed

Ekhlasi-Hundrieser, Mahnaz; Schäfer, Bettina; Philipp, Ute; Kuiper, Heidi; Leeb, Tosso; Mehta, Meenal; Kirchhoff, Christiane; Töpfer-Petersen, Edda

2007-05-01

Fibronectin type II (Fn2) module-containing proteins in the male genital tract are characterized by different numbers of Fn2 modules. Predominantly two classes exist which are distinct by having either two or four Fn2 modules. Minor variants with three Fn2 modules were also found in the human and the porcine epididymis. To reveal their relationship, mRNAs and proteins of representatives of these classes were studied in human, in Sus scrofa, and in rodents. Adult boars expressed members of both classes, i.e. ELSPBP1 and pB1, in subsequent regions of the epididymis, and both were under androgenic control. Human and rodent epididymides, on the other hand, alternatively contained only representatives of one of these two classes, i.e. ELSPBP1 in the human and two different pB1-related counterparts in rodents. ELSPBP1 and pB1-related genomic sequences were closely linked in chromosomal regions HSA 19q and SSC 6 q11-q21; conserved synteny between these regions is well established. On the other hand, in a syntenic region on mouse chromosome 7, ELSPBP1-related sequences were lacking. Tight binding to the sperm membrane via a choline-mediated mechanism was a common feature of the two classes of Fn2-module proteins, suggesting related function(s). However, differences in their regionalized expression patterns along the male genital tract as well as in association sites on the sperm surface suggested a species-specific sequential order in sperm binding.

Phenology of Honey Bee Swarm Departure in New Jersey, United States.

PubMed

Gilley, D C; Courtright, T J; Thom, C

2018-03-31

Departure of swarms from honey bee (Apis mellifera Linnaeus (Hymenoptera: Apidae)) nests is an important reproductive event for wild honey bee colonies and economically costly in managed bee colonies. The seasonal timing of swarm departure varies regionally and annually, creating challenges for honey bee management and emphasizing the potential for swarming behavior to be affected by plant-pollinator phenological mismatch. In this study, we first document variability in the timing of swarm departure across the large and heterogeneous geographical area of New Jersey over 4 years using 689 swarm-cluster observations. Second, hypothesizing that honey bee colonies adaptively tune the timing of swarm departure to match floral food-resource availability, we predicted that growing degree-days could be used to account for regional and annual variability. To test this idea, we used local weather records to determine the growing degree-day on which each swarm cluster was observed and tested for differences among climate regions and years. The state-wide mean swarm cluster date was May 15 (± 0.6 d), with moderate but significant differences among the state's five climate regions and between years. Use of degree-day information suggests that local heat accumulation can account for some climate-region differences in swarm-departure timing. Annual variation existed on a scale of only several days and was not accounted for by growing degree-days, suggesting little adaptive tuning of swarm-departure timing with respect to local heat accumulation.

Investigation of error sources in regional inverse estimates of greenhouse gas emissions in Canada

NASA Astrophysics Data System (ADS)

Chan, E.; Chan, D.; Ishizawa, M.; Vogel, F.; Brioude, J.; Delcloo, A.; Wu, Y.; Jin, B.

2015-08-01

Inversion models can use atmospheric concentration measurements to estimate surface fluxes. This study is an evaluation of the errors in a regional flux inversion model for different provinces of Canada, Alberta (AB), Saskatchewan (SK) and Ontario (ON). Using CarbonTracker model results as the target, the synthetic data experiment analyses examined the impacts of the errors from the Bayesian optimisation method, prior flux distribution and the atmospheric transport model, as well as their interactions. The scaling factors for different sub-regions were estimated by the Markov chain Monte Carlo (MCMC) simulation and cost function minimization (CFM) methods. The CFM method results are sensitive to the relative size of the assumed model-observation mismatch and prior flux error variances. Experiment results show that the estimation error increases with the number of sub-regions using the CFM method. For the region definitions that lead to realistic flux estimates, the numbers of sub-regions for the western region of AB/SK combined and the eastern region of ON are 11 and 4 respectively. The corresponding annual flux estimation errors for the western and eastern regions using the MCMC (CFM) method are -7 and -3 % (0 and 8 %) respectively, when there is only prior flux error. The estimation errors increase to 36 and 94 % (40 and 232 %) resulting from transport model error alone. When prior and transport model errors co-exist in the inversions, the estimation errors become 5 and 85 % (29 and 201 %). This result indicates that estimation errors are dominated by the transport model error and can in fact cancel each other and propagate to the flux estimates non-linearly. In addition, it is possible for the posterior flux estimates having larger differences than the prior compared to the target fluxes, and the posterior uncertainty estimates could be unrealistically small that do not cover the target. The systematic evaluation of the different components of the inversion model can help in the understanding of the posterior estimates and percentage errors. Stable and realistic sub-regional and monthly flux estimates for western region of AB/SK can be obtained, but not for the eastern region of ON. This indicates that it is likely a real observation-based inversion for the annual provincial emissions will work for the western region whereas; improvements are needed with the current inversion setup before real inversion is performed for the eastern region.

The assumed Aalenian stage-long eustatic lowstand did not exist: A review of the fresh evidence from Africa and other continents

NASA Astrophysics Data System (ADS)

Ruban, Dmitry A.; Sallam, Emad S.

2018-03-01

The views of the Jurassic eustatic fluctuations differ significantly: specialists either suggest multiple rises and falls ("Haq's view") or question the idea of global falls ("Hallam's view"). For instance, it is unclear whether there was a stage-long eustatic lowstand in the Aalenian. The presence of the noted alternatives is a serious problem complicating interpretation of events in the geological history. This paper summarizes the evidence of the Aalenian long-term shoreline shifts obtained in different regions of the world since 2000, i.e., after the noted views appeared. This evidence deals with the stratigraphical architecture of regions (interpreted in the present article), the established shoreline shifts (transgressions and regressions), and the knowledge of the regional tectonic activity. The compiled information characterizes "stable" regions located in the different parts of the world (Europe, Asia, Africa, North America, South America, and Australia). It is established that there were no regressions in some of these regions in the Aalenian, whereas regressions in the other regions can be explained by the influence of the tectonic activity. There was no coherence of the basin-scale eustatically-driven regressions (in contrast, the long-term Bajocian eustatic rise is proven by a coherence of regional transgressions). This finding contradicts the idea of the stage-long eustatic lowstand in the Aalenian and, thus, favours the "Hallam's view". This interpretation is in agreement with the present knowledge of the Earth's palaeoclimate and the past plate tectonics. This study demonstrates efficacy of interregional correlation of sea-level changes for resolution of the problem of the alternative views of the Jurassic eustasy.

Regionalization of precipitation characteristics in Iran's Lake Urmia basin

NASA Astrophysics Data System (ADS)

Fazel, Nasim; Berndtsson, Ronny; Uvo, Cintia Bertacchi; Madani, Kaveh; Kløve, Bjørn

2018-04-01

Lake Urmia in northwest Iran, once one of the largest hypersaline lakes in the world, has shrunk by almost 90% in area and 80% in volume during the last four decades. To improve the understanding of regional differences in water availability throughout the region and to refine the existing information on precipitation variability, this study investigated the spatial pattern of precipitation for the Lake Urmia basin. Daily rainfall time series from 122 precipitation stations with different record lengths were used to extract 15 statistical descriptors comprising 25th percentile, 75th percentile, and coefficient of variation for annual and seasonal total precipitation. Principal component analysis in association with cluster analysis identified three main homogeneous precipitation groups in the lake basin. The first sub-region (group 1) includes stations located in the center and southeast; the second sub-region (group 2) covers mostly northern and northeastern part of the basin, and the third sub-region (group 3) covers the western and southern edges of the basin. Results of principal component (PC) and clustering analyses showed that seasonal precipitation variation is the most important feature controlling the spatial pattern of precipitation in the lake basin. The 25th and 75th percentiles of winter and autumn are the most important variables controlling the spatial pattern of the first rotated principal component explaining about 32% of the total variance. Summer and spring precipitation variations are the most important variables in the second and third rotated principal components, respectively. Seasonal variation in precipitation amount and seasonality are explained by topography and influenced by the lake and westerly winds that are related to the strength of the North Atlantic Oscillation. Despite using incomplete time series with different lengths, the identified sub-regions are physically meaningful.

Modelling changes in small area disability free life expectancy: trends in London wards between 2001 and 2011.

PubMed

Congdon, Peter

2014-12-20

Existing analyses of trends in disability free life expectancy (DFLE) are mainly at aggregate level (national or broad regional). However, major differences in DFLE, and trends in these expectancies, exist between different neighbourhoods within regions, so supporting a small area perspective. However, this raises issues regarding the stability of conventional life table estimation methods at small area scales. This paper advocates a Bayesian borrowing strength technique to model trends in mortality and disability differences across 625 small areas in London, using illness data from the 2001 and 2011 population Censuses, and deaths data for two periods centred on the Census years. From this analysis, estimates of total life expectancy and DFLE are obtained. The spatio-temporal modelling perspective allows assessment of whether significant compression or expansion of morbidity has occurred in each small area. Appropriate models involve random effects that recognise correlation and interaction effects over relevant dimensions of the observed deaths and illness data (areas, ages), as well as major spatial trends (e.g. gradients in health and mortality according to area deprivation category). Whilst borrowing strength is a primary consideration (and demonstrated by raised precision for estimated life expectancies), so also is model parsimony. Therefore, pure borrowing strength models are compared with models allowing selection of random age-area interaction effects using a spike-slab prior, and in fact borrowing strength combined with random effects selection provides better fit. Copyright © 2014 John Wiley & Sons, Ltd.

Heterogeneity measures in hydrological frequency analysis: review and new developments

NASA Astrophysics Data System (ADS)

Requena, Ana I.; Chebana, Fateh; Ouarda, Taha B. M. J.

2017-03-01

Some regional procedures to estimate hydrological quantiles at ungauged sites, such as the index-flood method, require the delineation of homogeneous regions as a basic step for their application. The homogeneity of these delineated regions is usually tested providing a yes/no decision. However, complementary measures that are able to quantify the degree of heterogeneity of a region are needed to compare regions, evaluate the impact of particular sites, and rank the performance of different delineating methods. Well-known existing heterogeneity measures are not well-defined for ranking regions, as they entail drawbacks such as assuming a given probability distribution, providing negative values and being affected by the region size. Therefore, a framework for defining and assessing desirable properties of a heterogeneity measure in the regional hydrological context is needed. In the present study, such a framework is proposed through a four-step procedure based on Monte Carlo simulations. Several heterogeneity measures, some of which commonly known and others which are derived from recent approaches or adapted from other fields, are presented and developed to be assessed. The assumption-free Gini index applied on the at-site L-variation coefficient (L-CV) over a region led to the best results. The measure of the percentage of sites for which the regional L-CV is outside the confidence interval of the at-site L-CV is also found to be relevant, as it leads to more stable results regardless of the regional L-CV value. An illustrative application is also presented for didactical purposes, through which the subjectivity of commonly used criteria to assess the performance of different delineation methods is underlined.

Characteristics of precipitation recycling ratio with two evapotranspiration methods in Afro-Asian arid regions

NASA Astrophysics Data System (ADS)

Li, R.; Wang, C.

2016-12-01

The increasing precipitation in different arid regions has been observed in recent decades. While, the vapor sources, which can be classified into advective vapor and local vapor from evapotranspiration, are still uncertain in arid regions. To investigate the characteristics of local vapor in arid regions, precipitation recycling ratio (PRR) with two different evapotranspiration (ET) estimations, Penman-Monteith ET and a new approach which combined Penman-Monteith ET and surface soil moisture was calculated in arid regions of Afro-Asian continent, North Africa, West Asia and China-Mongolia, during 1980-2010. The results suggested that Penman-Monteith ET, which can be treated as regional potential ET, increased and showed an enhanced ET ability in arid regions. However, the ET calculated from the new approach, which can be treated as a reliable actual ET estimation, decreased, which means the local vapor has supplied less to total rainfall in target regions. Using the new approach ET data, PRR is calculated and analyzed. PRR in target regions ranges from 0.5% to 1.0%, which is less than the PRR calculated with Penman-Monteith ET, ranging from 3.7% to 5.6%. Meanwhile PRR decreased in China-Mongolia and North Africa while in West Asia increased in recent 30 years. Considering that a wetting trend existed in China-Mongolia and North Africa, and a drying trend occurred in West Asia, it can be concluded that PRR is a negative monitoring for Afro-Asian arid regions, where the decreasing PRR means that the more advective vapor enhanced the total precipitation, while the increasing PRR trend corresponds with less advective vapor and more local evapotranspiration contributes to increasing of total rainfall. Keywords: Afro-Asian Arid region, precipitation recycling, evapotranspiration, soil moisture.

No differences in emotion recognition strategies in children with autism spectrum disorder: evidence from hybrid faces.

PubMed

Evers, Kris; Kerkhof, Inneke; Steyaert, Jean; Noens, Ilse; Wagemans, Johan

2014-01-01

Emotion recognition problems are frequently reported in individuals with an autism spectrum disorder (ASD). However, this research area is characterized by inconsistent findings, with atypical emotion processing strategies possibly contributing to existing contradictions. In addition, an attenuated saliency of the eyes region is often demonstrated in ASD during face identity processing. We wanted to compare reliance on mouth versus eyes information in children with and without ASD, using hybrid facial expressions. A group of six-to-eight-year-old boys with ASD and an age- and intelligence-matched typically developing (TD) group without intellectual disability performed an emotion labelling task with hybrid facial expressions. Five static expressions were used: one neutral expression and four emotional expressions, namely, anger, fear, happiness, and sadness. Hybrid faces were created, consisting of an emotional face half (upper or lower face region) with the other face half showing a neutral expression. Results showed no emotion recognition problem in ASD. Moreover, we provided evidence for the existence of top- and bottom-emotions in children: correct identification of expressions mainly depends on information in the eyes (so-called top-emotions: happiness) or in the mouth region (so-called bottom-emotions: sadness, anger, and fear). No stronger reliance on mouth information was found in children with ASD.

Comparison of Test Procedures and Energy Efficiency Criteria in Selected International Standards and Labeling Programs for Clothes Washers, Water Dispensers, Vending Machines and CFLs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fridley, David; Zheng, Nina; Zhou, Nan

Since the late 1970s, energy labeling programs and mandatory energy performance standards have been used in many different countries to improve the efficiency levels of major residential and commercial equipment. As more countries and regions launch programs covering a greater range of products that are traded worldwide, greater attention has been given to harmonizing the specific efficiency criteria in these programs and the test methods for measurements. For example, an international compact fluorescent light (CFL) harmonization initiative was launched in 2006 to focus on collaboration between Australia, China, Europe and North America. Given the long history of standards and labelingmore » programs, most major energy-consuming residential appliances and commercial equipment are already covered under minimum energy performance standards (MEPS) and/or energy labels. For these products, such as clothes washers and CFLs, harmonization may still be possible when national MEPS or labeling thresholds are revised. Greater opportunity for harmonization exists in newer energy-consuming products that are not commonly regulated but are under consideration for new standards and labeling programs. This may include commercial products such as water dispensers and vending machines, which are only covered by MEPS or energy labels in a few countries or regions. As China continues to expand its appliance standards and labeling programs and revise existing standards and labels, it is important to learn from recent international experiences with efficiency criteria and test procedures for the same products. Specifically, various types of standards and labeling programs already exist in North America, Europe and throughout Asia for products in China's 2010 standards and labeling programs, namely clothes washers, water dispensers, vending machines and CFLs. This report thus examines similarities and critical differences in energy efficiency values, test procedure specifications and other technical performance requirements in existing international programs in order to shed light on where Chinese programs currently stands and considerations for their 2010 programs.« less

Food irradiation: regulatory aspects in the Asia and Pacific region

NASA Astrophysics Data System (ADS)

Luckman, Gary James

2002-03-01

Irradiation treatment of food is becoming an increasingly accepted processing option for countries in the Asia Pacific region wishing to meet growing sanitary and phytosanitary requirements in international trade. There remain however, large differences between the regulatory requirements in the countries in this region. This paper gives an outline on existing food irradiation regulations in the separate countries of the Asia Pacific region. New developments such as the recent decision by the Australia New Zealand Food Authority to start assessing applications for food irradiation treatment are discussed. Australia's intention to regulate the export of food treated by irradiation will also be outlined. Details of the decision to harmonise food irradiation regulations by 13 countries in the Asia Pacific region based on conformance with Codex requirements is outlined. The likelihood of other Asia Pacific countries enacting similar harmonisation of their regulations will be examined. Future development such as certification of irradiation as a sanitary treatment for food are discussed. The expected result of these initiatives is a likely increase in irradiated foods traded within the Asia Pacific region.

9 CFR 94.8 - Pork and pork products from regions where African swine fever exists or is reasonably believed to...

Code of Federal Regulations, 2012 CFR

2012-01-01

... where African swine fever exists or is reasonably believed to exist. 94.8 Section 94.8 Animals and... NEWCASTLE DISEASE, AFRICAN SWINE FEVER, CLASSICAL SWINE FEVER, SWINE VESICULAR DISEASE, AND BOVINE... where African swine fever exists or is reasonably believed to exist. African swine fever exists or the...

Standard Anatomic Terminologies: Comparison for Use in a Health Information Exchange–Based Prior Computed Tomography (CT) Alerting System

PubMed Central

Lowry, Tina; Vreeman, Daniel J; Loo, George T; Delman, Bradley N; Thum, Frederick L; Slovis, Benjamin H; Shapiro, Jason S

2017-01-01

Background A health information exchange (HIE)–based prior computed tomography (CT) alerting system may reduce avoidable CT imaging by notifying ordering clinicians of prior relevant studies when a study is ordered. For maximal effectiveness, a system would alert not only for prior same CTs (exams mapped to the same code from an exam name terminology) but also for similar CTs (exams mapped to different exam name terminology codes but in the same anatomic region) and anatomically proximate CTs (exams in adjacent anatomic regions). Notification of previous same studies across an HIE requires mapping of local site CT codes to a standard terminology for exam names (such as Logical Observation Identifiers Names and Codes [LOINC]) to show that two studies with different local codes and descriptions are equivalent. Notifying of prior similar or proximate CTs requires an additional mapping of exam codes to anatomic regions, ideally coded by an anatomic terminology. Several anatomic terminologies exist, but no prior studies have evaluated how well they would support an alerting use case. Objective The aim of this study was to evaluate the fitness of five existing standard anatomic terminologies to support similar or proximate alerts of an HIE-based prior CT alerting system. Methods We compared five standard anatomic terminologies (Foundational Model of Anatomy, Systematized Nomenclature of Medicine Clinical Terms, RadLex, LOINC, and LOINC/Radiological Society of North America [RSNA] Radiology Playbook) to an anatomic framework created specifically for our use case (Simple ANatomic Ontology for Proximity or Similarity [SANOPS]), to determine whether the existing terminologies could support our use case without modification. On the basis of an assessment of optimal terminology features for our purpose, we developed an ordinal anatomic terminology utility classification. We mapped samples of 100 random and the 100 most frequent LOINC CT codes to anatomic regions in each terminology, assigned utility classes for each mapping, and statistically compared each terminology’s utility class rankings. We also constructed seven hypothetical alerting scenarios to illustrate the terminologies’ differences. Results Both RadLex and the LOINC/RSNA Radiology Playbook anatomic terminologies ranked significantly better (P<.001) than the other standard terminologies for the 100 most frequent CTs, but no terminology ranked significantly better than any other for 100 random CTs. Hypothetical scenarios illustrated instances where no standard terminology would support appropriate proximate or similar alerts, without modification. Conclusions LOINC/RSNA Radiology Playbook and RadLex’s anatomic terminologies appear well suited to support proximate or similar alerts for commonly ordered CTs, but for less commonly ordered tests, modification of the existing terminologies with concepts and relations from SANOPS would likely be required. Our findings suggest SANOPS may serve as a framework for enhancing anatomic terminologies in support of other similar use cases. PMID:29242174

Empirical models for the prediction of ground motion duration for intraplate earthquakes

NASA Astrophysics Data System (ADS)

Anbazhagan, P.; Neaz Sheikh, M.; Bajaj, Ketan; Mariya Dayana, P. J.; Madhura, H.; Reddy, G. R.

2017-07-01

Many empirical relationships for the earthquake ground motion duration were developed for interplate region, whereas only a very limited number of empirical relationships exist for intraplate region. Also, the existing relationships were developed based mostly on the scaled recorded interplate earthquakes to represent intraplate earthquakes. To the author's knowledge, none of the existing relationships for the intraplate regions were developed using only the data from intraplate regions. Therefore, an attempt is made in this study to develop empirical predictive relationships of earthquake ground motion duration (i.e., significant and bracketed) with earthquake magnitude, hypocentral distance, and site conditions (i.e., rock and soil sites) using the data compiled from intraplate regions of Canada, Australia, Peninsular India, and the central and southern parts of the USA. The compiled earthquake ground motion data consists of 600 records with moment magnitudes ranging from 3.0 to 6.5 and hypocentral distances ranging from 4 to 1000 km. The non-linear mixed-effect (NLMEs) and logistic regression techniques (to account for zero duration) were used to fit predictive models to the duration data. The bracketed duration was found to be decreased with an increase in the hypocentral distance and increased with an increase in the magnitude of the earthquake. The significant duration was found to be increased with the increase in the magnitude and hypocentral distance of the earthquake. Both significant and bracketed durations were predicted higher in rock sites than in soil sites. The predictive relationships developed herein are compared with the existing relationships for interplate and intraplate regions. The developed relationship for bracketed duration predicts lower durations for rock and soil sites. However, the developed relationship for a significant duration predicts lower durations up to a certain distance and thereafter predicts higher durations compared to the existing relationships.

Functional brain networks in Alzheimer's disease: EEG analysis based on limited penetrable visibility graph and phase space method

NASA Astrophysics Data System (ADS)

Wang, Jiang; Yang, Chen; Wang, Ruofan; Yu, Haitao; Cao, Yibin; Liu, Jing

2016-10-01

In this paper, EEG series are applied to construct functional connections with the correlation between different regions in order to investigate the nonlinear characteristic and the cognitive function of the brain with Alzheimer's disease (AD). First, limited penetrable visibility graph (LPVG) and phase space method map single EEG series into networks, and investigate the underlying chaotic system dynamics of AD brain. Topological properties of the networks are extracted, such as average path length and clustering coefficient. It is found that the network topology of AD in several local brain regions are different from that of the control group with no statistically significant difference existing all over the brain. Furthermore, in order to detect the abnormality of AD brain as a whole, functional connections among different brain regions are reconstructed based on similarity of clustering coefficient sequence (CCSS) of EEG series in the four frequency bands (delta, theta, alpha, and beta), which exhibit obvious small-world properties. Graph analysis demonstrates that for both methodologies, the functional connections between regions of AD brain decrease, particularly in the alpha frequency band. AD causes the graph index complexity of the functional network decreased, the small-world properties weakened, and the vulnerability increased. The obtained results show that the brain functional network constructed by LPVG and phase space method might be more effective to distinguish AD from the normal control than the analysis of single series, which is helpful for revealing the underlying pathological mechanism of the disease.

Controlled ultrafast transfer and stability degree of generalized coherent states of a kicked two-level ion

NASA Astrophysics Data System (ADS)

Chen, Hao; Kong, Chao; Hai, Wenhua

2018-06-01

We investigate quantum dynamics of a two-level ion trapped in the Lamb-Dicke regime of a δ -kicked optical lattice, based on the exact generalized coherent states rotated by a π / 2 pulse of Ramsey type experiment. The spatiotemporal evolutions of the spin-motion entangled states in different parameter regions are illustrated, and the parameter regions of different degrees of quantum stability described by the quantum fidelity are found. Time evolutions of the probability for the ion being in different pseudospin states reveal that the ultrafast entanglement generation and population transfers of the system can be analytically controlled by managing the laser pulses. The probability in an initially disentangled state shows periodic collapses (entanglement) and revivals (de-entanglement). Reduction of the stability degree results in enlarging the period of de-entanglement, while the instability and potential chaos will cause the sustained entanglement. The results could be justified experimentally in the existing setups and may be useful in engineering quantum dynamics for quantum information processing.

Study of different concentric rings inside gallstones with LIBS.

PubMed

Pathak, Ashok Kumar; Singh, Vivek Kumar; Rai, Nilesh Kumar; Rai, Awadhesh Kumar; Rai, Pradeep Kumar; Rai, Pramod Kumar; Rai, Suman; Baruah, G D

2011-07-01

Gallstones obtained from patients from the north-east region of India (Assam) were studied using laser-induced breakdown spectroscopy (LIBS) technique. LIBS spectra of the different layers (in cross-section) of the gallstones were recorded in the spectral region 200-900 nm. Several elements, including calcium, magnesium, manganese, copper, silicon, phosphorus, iron, sodium and potassium, were detected in the gallstones. Lighter elements, including carbon, hydrogen, nitrogen and oxygen were also detected, which demonstrates the superiority of the LIBS technique over other existing analytical techniques. The LIBS technique was applied to investigate the evolution of C(2) swan bands and CN violet bands in the LIBS spectra of the gallstones in air and an argon atmosphere. The different layers (dark and light layers) of the gallstones were discriminated on the basis of the presence and intensities of the spectral lines for carbon, hydrogen, nitrogen, oxygen and copper. An attempt was also made to correlate the presence of major and minor elements in the gallstones with the common diet of the population of Assam.

The role of country-to-region assignments in global integrated modeling of energy, agriculture, land use, and climate

NASA Astrophysics Data System (ADS)

Kyle, P.; Patel, P.; Calvin, K. V.

2014-12-01

Global integrated assessment models used for understanding the linkages between the future energy, agriculture, and climate systems typically represent between 8 and 30 geopolitical macro-regions, balancing the benefits of geographic resolution with the costs of additional data collection, processing, analysis, and computing resources. As these models are continually being improved and updated in order to address new questions for the research and policy communities, it is worth examining the consequences of the country-to-region mapping schemes used for model results. This study presents an application of a data processing system built for the GCAM integrated assessment model that allows any country-to-region assignments, with a minimum of four geopolitical regions and a maximum of 185. We test ten different mapping schemes, including the specific mappings used in existing major integrated assessment models. We also explore the impacts of clustering nations into regions according to the similarity of the structure of each nation's energy and agricultural sectors, as indicated by multivariate analysis. Scenarios examined include a reference scenario, a low-emissions scenario, and scenarios with agricultural and buildings sector climate change impacts. We find that at the global level, the major output variables (primary energy, agricultural land use) are surprisingly similar regardless of regional assignments, but at finer geographic scales, differences are pronounced. We suggest that enhancing geographic resolution is advantageous for analysis of climate impacts on the buildings and agricultural sectors, due to the spatial heterogeneity of these drivers.

Discovery of novel targets for multi-epitope vaccines: Screening of HIV-1 genomes using association rule mining

PubMed Central

Paul, Sinu; Piontkivska, Helen

2009-01-01

Background Studies have shown that in the genome of human immunodeficiency virus (HIV-1) regions responsible for interactions with the host's immune system, namely, cytotoxic T-lymphocyte (CTL) epitopes tend to cluster together in relatively conserved regions. On the other hand, "epitope-less" regions or regions with relatively low density of epitopes tend to be more variable. However, very little is known about relationships among epitopes from different genes, in other words, whether particular epitopes from different genes would occur together in the same viral genome. To identify CTL epitopes in different genes that co-occur in HIV genomes, association rule mining was used. Results Using a set of 189 best-defined HIV-1 CTL/CD8+ epitopes from 9 different protein-coding genes, as described by Frahm, Linde & Brander (2007), we examined the complete genomic sequences of 62 reference HIV sequences (including 13 subtypes and sub-subtypes with approximately 4 representative sequences for each subtype or sub-subtype, and 18 circulating recombinant forms). The results showed that despite inclusion of recombinant sequences that would be expected to break-up associations of epitopes in different genes when two different genomes are recombined, there exist particular combinations of epitopes (epitope associations) that occur repeatedly across the world-wide population of HIV-1. For example, Pol epitope LFLDGIDKA is found to be significantly associated with epitopes GHQAAMQML and FLKEKGGL from Gag and Nef, respectively, and this association rule is observed even among circulating recombinant forms. Conclusion We have identified CTL epitope combinations co-occurring in HIV-1 genomes including different subtypes and recombinant forms. Such co-occurrence has important implications for design of complex vaccines (multi-epitope vaccines) and/or drugs that would target multiple HIV-1 regions at once and, thus, may be expected to overcome challenges associated with viral escape. PMID:19580659

4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments.

PubMed

Raviram, Ramya; Rocha, Pedro P; Müller, Christian L; Miraldi, Emily R; Badri, Sana; Fu, Yi; Swanzey, Emily; Proudhon, Charlotte; Snetkova, Valentina; Bonneau, Richard; Skok, Jane A

2016-03-01

4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or "bait") that can be important for gene regulation. However, analysis of 4C-Seq data is complicated by the many biases inherent to the technique. An important consideration when dealing with 4C-Seq data is the differences in resolution of signal across the genome that result from differences in 3D distance separation from the bait. This leads to the highest signal in the region immediately surrounding the bait and increasingly lower signals in far-cis and trans. Another important aspect of 4C-Seq experiments is the resolution, which is greatly influenced by the choice of restriction enzyme and the frequency at which it can cut the genome. Thus, it is important that a 4C-Seq analysis method is flexible enough to analyze data generated using different enzymes and to identify interactions across the entire genome. Current methods for 4C-Seq analysis only identify interactions in regions near the bait or in regions located in far-cis and trans, but no method comprehensively analyzes 4C signals of different length scales. In addition, some methods also fail in experiments where chromatin fragments are generated using frequent cutter restriction enzymes. Here, we describe 4C-ker, a Hidden-Markov Model based pipeline that identifies regions throughout the genome that interact with the 4C bait locus. In addition, we incorporate methods for the identification of differential interactions in multiple 4C-seq datasets collected from different genotypes or experimental conditions. Adaptive window sizes are used to correct for differences in signal coverage in near-bait regions, far-cis and trans chromosomes. Using several datasets, we demonstrate that 4C-ker outperforms all existing 4C-Seq pipelines in its ability to reproducibly identify interaction domains at all genomic ranges with different resolution enzymes.

4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments

PubMed Central

Raviram, Ramya; Rocha, Pedro P.; Müller, Christian L.; Miraldi, Emily R.; Badri, Sana; Fu, Yi; Swanzey, Emily; Proudhon, Charlotte; Snetkova, Valentina

2016-01-01

4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or “bait”) that can be important for gene regulation. However, analysis of 4C-Seq data is complicated by the many biases inherent to the technique. An important consideration when dealing with 4C-Seq data is the differences in resolution of signal across the genome that result from differences in 3D distance separation from the bait. This leads to the highest signal in the region immediately surrounding the bait and increasingly lower signals in far-cis and trans. Another important aspect of 4C-Seq experiments is the resolution, which is greatly influenced by the choice of restriction enzyme and the frequency at which it can cut the genome. Thus, it is important that a 4C-Seq analysis method is flexible enough to analyze data generated using different enzymes and to identify interactions across the entire genome. Current methods for 4C-Seq analysis only identify interactions in regions near the bait or in regions located in far-cis and trans, but no method comprehensively analyzes 4C signals of different length scales. In addition, some methods also fail in experiments where chromatin fragments are generated using frequent cutter restriction enzymes. Here, we describe 4C-ker, a Hidden-Markov Model based pipeline that identifies regions throughout the genome that interact with the 4C bait locus. In addition, we incorporate methods for the identification of differential interactions in multiple 4C-seq datasets collected from different genotypes or experimental conditions. Adaptive window sizes are used to correct for differences in signal coverage in near-bait regions, far-cis and trans chromosomes. Using several datasets, we demonstrate that 4C-ker outperforms all existing 4C-Seq pipelines in its ability to reproducibly identify interaction domains at all genomic ranges with different resolution enzymes. PMID:26938081

40 CFR 52.675 - Control strategy: Sulfur oxides-Eastern Idaho Intrastate Air Quality Control Region.

Code of Federal Regulations, 2014 CFR

2014-07-01

... of Sulfur Oxide Emissions from Sulfuric Acid Plants) of the “Rules and Regulations for the Control of... have previously been established for certain existing acid plants in this Air Quality Control Region... apply to existing acid plants with approved or promulgated emission limits that are more stringent than...

40 CFR 52.675 - Control strategy: Sulfur oxides-Eastern Idaho Intrastate Air Quality Control Region.

Code of Federal Regulations, 2013 CFR

2013-07-01

... of Sulfur Oxide Emissions from Sulfuric Acid Plants) of the “Rules and Regulations for the Control of... have previously been established for certain existing acid plants in this Air Quality Control Region... apply to existing acid plants with approved or promulgated emission limits that are more stringent than...

40 CFR 52.675 - Control strategy: Sulfur oxides-Eastern Idaho Intrastate Air Quality Control Region.

Code of Federal Regulations, 2012 CFR

2012-07-01

... of Sulfur Oxide Emissions from Sulfuric Acid Plants) of the “Rules and Regulations for the Control of... have previously been established for certain existing acid plants in this Air Quality Control Region... apply to existing acid plants with approved or promulgated emission limits that are more stringent than...

40 CFR 52.675 - Control strategy: Sulfur oxides-Eastern Idaho Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... of Sulfur Oxide Emissions from Sulfuric Acid Plants) of the “Rules and Regulations for the Control of... have previously been established for certain existing acid plants in this Air Quality Control Region... apply to existing acid plants with approved or promulgated emission limits that are more stringent than...

40 CFR 52.675 - Control strategy: Sulfur oxides-Eastern Idaho Intrastate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

... of Sulfur Oxide Emissions from Sulfuric Acid Plants) of the “Rules and Regulations for the Control of... have previously been established for certain existing acid plants in this Air Quality Control Region... apply to existing acid plants with approved or promulgated emission limits that are more stringent than...

Two new turrid species (Gastropoda: Pseudomelatomidae) from the Palawan region, the Philippines.

PubMed

Stahlschmidt, Peter; Fraussen, Koen

2014-03-26

Species richness of tropical marine molluscs is considerably underestimated (Bouchet et al. 2002). Indeed, the molluscan faunas of some regions, such as Palawan in the western Pacific, have received little attention and some hyper-diverse groups, such as the turrids (a parapyhletic group of Conoidea, formerly known as Turridae), are barely documented. For example, apart from original descriptions of two turrid taxa that have their type locations in Palawan (Comitas aequatorialis palawanica Powell, 1969 and Mangilia quadrasi Boettger, 1895 = Gingicithara notabilis (E. A. Smith, 1888)), there are no published records of turrids from this region. We have been fortunate to have access to recent collections of turrids from different parts of Palawan. Examination of these materials has revealed existence of several undescribed and potentially endemic species. In the present paper two new Pseudomelatomidae species are described.

Imaging, microscopic analysis, and modeling of a CdTe module degraded by heat and light

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnston, Steve; Albin, David; Hacke, Peter

Photoluminescence (PL), electroluminescence (EL), and dark lock-in thermography are collected during stressing of a CdTe module under one-Sun light at an elevated temperature of 100 degrees C. The PL imaging system is simple and economical. The PL images show differing degrees of degradation across the module and are less sensitive to effects of shunting and resistance that appear on the EL images. Regions of varying degradation are chosen based on avoiding pre-existing shunt defects. These regions are evaluated using time-of-flight secondary ion-mass spectrometry and Kelvin probe force microscopy. Reduced PL intensity correlates to increased Cu concentration at the front interface.more » Numerical modeling and measurements agree that the increased Cu concentration at the junction also correlates to a reduced space charge region.« less

Connectivity precedes function in the development of the visual word form area.

PubMed

Saygin, Zeynep M; Osher, David E; Norton, Elizabeth S; Youssoufian, Deanna A; Beach, Sara D; Feather, Jenelle; Gaab, Nadine; Gabrieli, John D E; Kanwisher, Nancy

2016-09-01

What determines the cortical location at which a given functionally specific region will arise in development? We tested the hypothesis that functionally specific regions develop in their characteristic locations because of pre-existing differences in the extrinsic connectivity of that region to the rest of the brain. We exploited the visual word form area (VWFA) as a test case, scanning children with diffusion and functional imaging at age 5, before they learned to read, and at age 8, after they learned to read. We found the VWFA developed functionally in this interval and that its location in a particular child at age 8 could be predicted from that child's connectivity fingerprints (but not functional responses) at age 5. These results suggest that early connectivity instructs the functional development of the VWFA, possibly reflecting a general mechanism of cortical development.

Imaging, microscopic analysis, and modeling of a CdTe module degraded by heat and light

DOE PAGES

Johnston, Steve; Albin, David; Hacke, Peter; ...

2018-01-12

Photoluminescence (PL), electroluminescence (EL), and dark lock-in thermography are collected during stressing of a CdTe module under one-Sun light at an elevated temperature of 100 degrees C. The PL imaging system is simple and economical. The PL images show differing degrees of degradation across the module and are less sensitive to effects of shunting and resistance that appear on the EL images. Regions of varying degradation are chosen based on avoiding pre-existing shunt defects. These regions are evaluated using time-of-flight secondary ion-mass spectrometry and Kelvin probe force microscopy. Reduced PL intensity correlates to increased Cu concentration at the front interface.more » Numerical modeling and measurements agree that the increased Cu concentration at the junction also correlates to a reduced space charge region.« less

[Incentive for Regional Risk Selection in the German Risk Structure Compensation Scheme].

PubMed

Wende, Danny

2017-10-01

The introduction of the new law GKV-FQWG strengthens the competition between statutory health insurance. If incentives for risk selection exist, they may force a battle for cheap customers. This study aims to document and discuss incentives for regional risk selection in the German risk structure compensation scheme. Identify regional autocorrelation with Moran's l on financial parameters of the risk structure compensation schema. Incentives for regional risk selection do indeed exist. The risk structure compensation schema reduces 91% of the effect and helps to reduce risk selection. Nevertheless, a connection between regional situation and competition could be shown (correlation: 69.5%). Only the integration of regional control variables into the risk compensation eliminates regional autocorrelation. The actual risk structure compensation is leading to regional inequalities and as a consequence to risk selection and distortion in competition. © Georg Thieme Verlag KG Stuttgart · New York.

Existing capacity to manage pharmaceuticals and related commodities in East Africa: an assessment with specific reference to antiretroviral therapy

PubMed Central

Waako, Paul J; Odoi-adome, Richard; Obua, Celestino; Owino, Erisa; Tumwikirize, Winnie; Ogwal-okeng, Jasper; Anokbonggo, Willy W; Matowe, Lloyd; Aupont, Onesky

2009-01-01

Background East African countries have in the recent past experienced a tremendous increase in the volume of antiretroviral drugs. Capacity to manage these medicines in the region remains limited. Makerere University, with technical assistance from the USAID supported Rational Pharmaceutical Management Plus (RPM Plus) Program of Management Sciences for Health (MSH) established a network of academic institutions to build capacity for pharmaceutical management in the East African region. The initiative includes institutions from Uganda, Tanzania, Kenya and Rwanda and aims to improve access to safe, effective and quality-assured medicines for the treatment of HIV/AIDS, TB and Malaria through spearheading in-country capacity. The initiative conducted a regional assessment to determine the existing capacity for the management of antiretroviral drugs and related commodities. Methods Heads and implementing workers of fifty HIV/AIDS programs and institutions accredited to offer antiretroviral services in Uganda, Kenya, Tanzania and Rwanda were key informants in face-to-face interviews guided by structured questionnaires. The assessment explored categories of health workers involved in the management of ARVs, their knowledge and practices in selection, quantification, distribution and use of ARVs, nature of existing training programs, training preferences and resources for capacity building. Results Inadequate human resource capacity including, inability to select, quantify and distribute ARVs and related commodities, and irrational prescribing and dispensing were some of the problems identified. A competence gap existed in all the four countries with a variety of healthcare professionals involved in the supply and distribution of ARVs. Training opportunities and resources for capacity development were limited particularly for workers in remote facilities. On-the-job training and short courses were the preferred modes of training. Conclusion There is inadequate capacity for managing medicines and related commodities in East Africa. There is an urgent need for training in aspects of pharmaceutical management to different categories of health workers. Skills building activities that do not take healthcare workers from their places of work are preferred. PMID:19272134

[New exploration on clinical treatment of injuries caused by uncommon agents or in extraordinary regions].

PubMed

Liu, Y

2018-05-20

Burns caused by uncommon agents means those caused by other agents except heating power, with special characteristics existing in traumatogenesis, pathophysiology, and clinical manifestation. With the development of social economy, various new techniques and new equipments are springing up. In the practical use, improper operations would become traumatogenic agents and cause various special types of trauma. In addition, some special injuries emerged with the changes in people's lifestyle. For battle injury, some new war wounds, which are different from fire-arm injuries in the past, appeared with the emergence of acoustic wave, light wave, electrical and magnetic weapons. Extraordinary regions are those located on body surface with anatomic and physiological particularity. Injuries caused by uncommon traumatogenic agent or in extraordinary region are different from those ordinary burns and trauma, and their clinical treatments have special characteristics. Clinical treatments were studied aiming at these special characteristics, and some achievements in treatment of high-voltage electrical burn, hydrofluoric acid burn, wounds on special regions, and new types of burns and trauma have been made. However, a doctor's duty is not only to cure the diseases and save the patients' lives, but also to prevent the diseases. The suitable treatment and precautionary measures for the new types of burns and trauma that differ from ordinary burns and trauma in the past remain to be explored.

Short note: the experimental geopotential model XGM2016

NASA Astrophysics Data System (ADS)

Pail, R.; Fecher, T.; Barnes, D.; Factor, J. F.; Holmes, S. A.; Gruber, T.; Zingerle, P.

2018-04-01

As a precursor study for the upcoming combined Earth Gravitational Model 2020 (EGM2020), the Experimental Gravity Field Model XGM2016, parameterized as a spherical harmonic series up to degree and order 719, is computed. XGM2016 shares the same combination methodology as its predecessor model GOCO05c (Fecher et al. in Surv Geophys 38(3): 571-590, 2017. doi: 10.1007/s10712-016-9406-y). The main difference between these models is that XGM2016 is supported by an improved terrestrial data set of 15^' × 15^' gravity anomaly area-means provided by the United States National Geospatial-Intelligence Agency (NGA), resulting in significant upgrades compared to existing combined gravity field models, especially in continental areas such as South America, Africa, parts of Asia, and Antarctica. A combination strategy of relative regional weighting provides for improved performance in near-coastal ocean regions, including regions where the altimetric data are mostly unchanged from previous models. Comparing cumulative height anomalies, from both EGM2008 and XGM2016 at degree/order 719, yields differences of 26 cm in Africa and 40 cm in South America. These differences result from including additional information of satellite data, as well as from the improved ground data in these regions. XGM2016 also yields a smoother Mean Dynamic Topography with significantly reduced artifacts, which indicates an improved modeling of the ocean areas.

Transport of passive scalars in a turbulent channel flow

NASA Technical Reports Server (NTRS)

Kim, John; Moin, Parviz

1987-01-01

A direct numerical simulation of a turbulent channel flow with three passive scalars at different molecular Prandtl numbers is performed. Computed statistics including the turbulent Prandtl numbers are compared with existing experimental data. The computed fields are also examined to investigate the spatial structure of the scalar fields. The scalar fields are highly correlated with the streamwise velocity; the correlation coefficient between the temperature and the streamwise velocity is as high as 0.95 in the wall region. The joint probability distributions between the temperature and velocity fluctuations are also examined; they suggest that it might be possible to model the scalar fluxes in the wall region in a manner similar to the Reynolds stresses.

Limit cycles in piecewise-affine gene network models with multiple interaction loops

NASA Astrophysics Data System (ADS)

Farcot, Etienne; Gouzé, Jean-Luc

2010-01-01

In this article, we consider piecewise affine differential equations modelling gene networks. We work with arbitrary decay rates, and under a local hypothesis expressed as an alignment condition of successive focal points. The interaction graph of the system may be rather complex (multiple intricate loops of any sign, multiple thresholds, etc.). Our main result is an alternative theorem showing that if a sequence of region is periodically visited by trajectories, then under our hypotheses, there exists either a unique stable periodic solution, or the origin attracts all trajectories in this sequence of regions. This result extends greatly our previous work on a single negative feedback loop. We give several examples and simulations illustrating different cases.

Resonant-tunneling oscillators and multipliers for submillimeter receivers

NASA Technical Reports Server (NTRS)

Sollner, T. C. L. Gerhard

1988-01-01

Resonant tunneling through double-barrier heterostructures has attracted increasing interest recently, largely because of the fast charge transport it provides. In addition, the negative differential resistance regions that exist in the current-voltage (I-V) curve (peak-to-valley ratios of 3.5:1 at room temperature, and nearly 10:1 at 77 K, were measured) suggest that high-speed devices based on the character of the I-V curve should be possible. For example, the negative differential resistance region is capable of providing the gain necessary for high-frequency oscillations. In the laboratory attempts were made to increase the frequency and power of these oscillators and to demonstrate several different high-frequency devices.

The labor force and urbanization in the Middle East: analysis and policy.

PubMed

Bean, L L

1983-01-01

"The purpose of this paper is to describe and comment on the labor force movements in the Middle East with particular reference to the implications of these flows for the process of urbanization in the region. [The author deals] with both international transfers of labor and internal movements of labor to urban communities." The international flow of labor in the Middle East in general is first examined, and a classification scheme is outlined to identify the major differences that exist within the region. Internal labor force migration is then analyzed using data for Libya. The final sections of the paper deal with data collection and policy issues. excerpt

Effects of concentration on the microwave dielectric spectra of aqueous urea solutions

NASA Astrophysics Data System (ADS)

Lyashchenko, A. K.; Dunyashev, V. S.; Zasetsky, A. Yu.

2017-05-01

Several models of relaxation for the dielectric spectra of aqueous urea solutions in the microwave region are compared. The spectra are shown to contain two main Debye components arising from the rotational motions of urea and water molecules. Two essentially different concentration regions in urea solutions are identified. The first is characterized by a small increase in the mobility of water molecules (τ1 = 7.8 ps) and the existence of hydrated urea molecules (τ2 = 19 ps). Due to the aggregation of urea molecules, the relaxation times for the latter process grow considerably in highly concentrated solutions. At the same time, faster molecular motions (τ3 = 6 ps) are observed for water molecules.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marekova, Elisaveta

Series of relatively large earthquakes in different regions of the Earth are studied. The regions chooses are of a high seismic activity and has a good contemporary network for recording of the seismic events along them. The main purpose of this investigation is the attempt to describe analytically the seismic process in the space and time. We are considering the statistical distributions the distances and the times between consecutive earthquakes (so called pair analysis). Studies conducted on approximating the statistical distribution of the parameters of consecutive seismic events indicate the existence of characteristic functions that describe them best. Such amore » mathematical description allows the distributions of the examined parameters to be compared to other model distributions.« less

Primary Care Performance Measurement and Reporting at a Regional Level: Could a Matrix Approach Provide Actionable Information for Policy Makers and Clinicians?

PubMed

Langton, Julia M; Wong, Sabrina T; Johnston, Sharon; Abelson, Julia; Ammi, Mehdi; Burge, Fred; Campbell, John; Haggerty, Jeannie; Hogg, William; Wodchis, Walter P; McGrail, Kimberlyn

2016-11-01

Primary care services form the foundation of modern healthcare systems, yet the breadth and complexity of services and diversity of patient populations may present challenges for creating comprehensive primary care information systems. Our objective is to develop regional-level information on the performance of primary care in Canada. A scoping review was conducted to identify existing initiatives in primary care performance measurement and reporting across 11 countries. The results of this review were used by our international team of primary care researchers and clinicians to propose an approach for regional-level primary care reporting. We found a gap between conceptual primary care performance measurement frameworks in the peer-reviewed literature and real-world primary care performance measurement and reporting activities. We did not find a conceptual framework or analytic approach that could readily form the foundation of a regional-level primary care information system. Therefore, we propose an approach to reporting comprehensive and actionable performance information according to widely accepted core domains of primary care as well as different patient population groups. An approach that bridges the gap between conceptual frameworks and real-world performance measurement and reporting initiatives could address some of the potential pitfalls of existing ways of presenting performance information (i.e., by single diseases or by age). This approach could produce meaningful and actionable information on the quality of primary care services. Copyright © 2016 Longwoods Publishing.

Primary Care Performance Measurement and Reporting at a Regional Level: Could a Matrix Approach Provide Actionable Information for Policy Makers and Clinicians?

PubMed Central

Langton, Julia M.; Wong, Sabrina T.; Johnston, Sharon; Abelson, Julia; Ammi, Mehdi; Burge, Fred; Campbell, John; Haggerty, Jeannie; Hogg, William; Wodchis, Walter P.

2016-01-01

Objective: Primary care services form the foundation of modern healthcare systems, yet the breadth and complexity of services and diversity of patient populations may present challenges for creating comprehensive primary care information systems. Our objective is to develop regional-level information on the performance of primary care in Canada. Methods: A scoping review was conducted to identify existing initiatives in primary care performance measurement and reporting across 11 countries. The results of this review were used by our international team of primary care researchers and clinicians to propose an approach for regional-level primary care reporting. Results: We found a gap between conceptual primary care performance measurement frameworks in the peer-reviewed literature and real-world primary care performance measurement and reporting activities. We did not find a conceptual framework or analytic approach that could readily form the foundation of a regional-level primary care information system. Therefore, we propose an approach to reporting comprehensive and actionable performance information according to widely accepted core domains of primary care as well as different patient population groups. Conclusions: An approach that bridges the gap between conceptual frameworks and real-world performance measurement and reporting initiatives could address some of the potential pitfalls of existing ways of presenting performance information (i.e., by single diseases or by age). This approach could produce meaningful and actionable information on the quality of primary care services. PMID:28032823

Intragenomic polymorphisms among high-copy loci: a genus-wide study of nuclear ribosomal DNA in Asclepias (Apocynaceae).

PubMed

Weitemier, Kevin; Straub, Shannon C K; Fishbein, Mark; Liston, Aaron

2015-01-01

Despite knowledge that concerted evolution of high-copy loci is often imperfect, studies that investigate the extent of intragenomic polymorphisms and comparisons across a large number of species are rarely made. We present a bioinformatic pipeline for characterizing polymorphisms within an individual among copies of a high-copy locus. Results are presented for nuclear ribosomal DNA (nrDNA) across the milkweed genus, Asclepias. The 18S-26S portion of the nrDNA cistron of Asclepias syriaca served as a reference for assembly of the region from 124 samples representing 90 species of Asclepias. Reads were mapped back to each individual's consensus and at each position reads differing from the consensus were tallied using a custom perl script. Low frequency polymorphisms existed in all individuals (mean = 5.8%). Most nrDNA positions (91%) were polymorphic in at least one individual, with polymorphic sites being less frequent in subunit regions and loops. Highly polymorphic sites existed in each individual, with highest abundance in the "noncoding" ITS regions. Phylogenetic signal was present in the distribution of intragenomic polymorphisms across the genus. Intragenomic polymorphisms in nrDNA are common in Asclepias, being found at higher frequency than any other study to date. The high and variable frequency of polymorphisms across species highlights concerns that phylogenetic applications of nrDNA may be error-prone. The new analytical approach provided here is applicable to other taxa and other high-copy regions characterized by low coverage genome sequencing (genome skimming).

From protein sequence to dynamics and disorder with DynaMine.

PubMed

Cilia, Elisa; Pancsa, Rita; Tompa, Peter; Lenaerts, Tom; Vranken, Wim F

2013-01-01

Protein function and dynamics are closely related; however, accurate dynamics information is difficult to obtain. Here based on a carefully assembled data set derived from experimental data for proteins in solution, we quantify backbone dynamics properties on the amino-acid level and develop DynaMine--a fast, high-quality predictor of protein backbone dynamics. DynaMine uses only protein sequence information as input and shows great potential in distinguishing regions of different structural organization, such as folded domains, disordered linkers, molten globules and pre-structured binding motifs of different sizes. It also identifies disordered regions within proteins with an accuracy comparable to the most sophisticated existing predictors, without depending on prior disorder knowledge or three-dimensional structural information. DynaMine provides molecular biologists with an important new method that grasps the dynamical characteristics of any protein of interest, as we show here for human p53 and E1A from human adenovirus 5.

Thermochronologic constraints on the tectonic evolution of the western Antarctic Peninsula in late Mesozoic and Cenozoic times

USGS Publications Warehouse

Brix, M.R.; Faundez, V.; Hervé, F.; Solari, M.; Fernandez, J.; Carter, A.; Stöckhert, B.

2007-01-01

West of the Antarctic Peninsula, oceanic lithosphere of the Phoenix plate has been subducted below the Antarctic plate. Subduction has ceased successively from south to north over the last 65 Myr. An influence of this evolution on the segmentation of the crust in the Antarctic plate is disputed. Opposing scenarios consider effects of ridge crest – trench interactions with the subduction zone or differences in slip along a basal detachment in the overriding plate. Fission track (FT) analyses on apatites and zircons may detect thermochronologic patterns to test these hypotheses. While existing data concentrate on accretionary processes in Palmer Land, new data extend information to the northern part of the Antarctic Peninsula. Zircons from different geological units over wide areas of the Antarctic Peninsula yield fission track ages between 90 and 80 Ma, indicating a uniform regional cooling episode. Apatite FT ages obtained so far show considerable regional variability

Approaches to Establishing the Chemical Structure of Extraterrestrial Organic Solids

NASA Technical Reports Server (NTRS)

Cody, G. D.; Alexander, C. M. OD.; Wirick, Susan

2003-01-01

The majority of extraterrestrial organic matter in carbonaceous chondrites resides in a chemically complex, insoluble and perhaps macromolecular phase. We have been applying a series of independent solid state NMR experiments that are designed to provide a self consistent chemical characterization of this complex material. To date we have thoroughly analyzed 8 organic residues from different meteorites, including a CR2 (EET92042), CIl(Orgueil), CM2 (Murchison), Tagish Lake, CM2 (AlH83100), CM2 (Cold Bokkefeld), CM2 (Mighei), CM3 (Y86720). In fig 1. (1)H to (13)C cross polarization NMR spectra of four of these are shown. Note that there exists an enormous range in chemistry exhibited in organic solid [evident by the breadth of the spectral features both in the aliphatic region (sp(sup 3)) and the aromatic region (sp(sup 2))]. There is also considerable differences in the carbon chemistry across the meteorite groups.

Chromosome ends: different sequences may provide conserved functions.

PubMed

Louis, Edward J; Vershinin, Alexander V

2005-07-01

The structures of specific chromosome regions, centromeres and telomeres, present a number of puzzles. As functions performed by these regions are ubiquitous and essential, their DNA, proteins and chromatin structure are expected to be conserved. Recent studies of centromeric DNA from human, Drosophila and plant species have demonstrated that a hidden universal centromere-specific sequence is highly unlikely. The DNA of telomeres is more conserved consisting of a tandemly repeated 6-8 bp Arabidopsis-like sequence in a majority of organisms as diverse as protozoan, fungi, mammals and plants. However, there are alternatives to short DNA repeats at the ends of chromosomes and for telomere elongation by telomerase. Here we focus on the similarities and diversity that exist among the structural elements, DNA sequences and proteins, that make up terminal domains (telomeres and subtelomeres), and how organisms use these in different ways to fulfil the functions of end-replication and end-protection. Copyright (c) 2005 Wiley Periodicals, Inc.

Diagnostics and structure

NASA Technical Reports Server (NTRS)

Vial, J. C.

1986-01-01

The structure of prominences and the diagnostic techniques used to evaluate their physical parameters are discussed. These include electron temperature, various densities (n sub p, n sub e, n sub l), ionization degree, velocities, and magnetic field vector. UV and radio measurements have already evidenced the existence of different temperature regions, corresponding to different geometrical locations, e.g., the so called Prominence-Corona (P-C) interface. Velocity measurements are important for considering formation and mass balance of prominences but there are conflicting velocity measurements which have led to the basic question: what structure is actually observed at a given wavelength; what averaging is performed within the projected slit area during the exposure time? In optically thick lines, the question of the formation region of the radiation along the line of sight is also not a trivial one. The same is true for low resolution measurements of the magnetic field. Coupling diagnostics with structure is now a general preoccupation.

Chromonic liquid crystalline nematic phase exhibited in binary mixture of two liquid crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Govindaiah, T. N., E-mail: tngovi.phy@gmail.com; Sreepad, H. R.; Sridhar, K. N.

2015-06-24

A binary mixture of abietic acid and orthophosphoric acid (H{sub 3}PO{sub 4}) exhibits co-existence of biphasic region of Nematic+Isotropic (N+I), lyotropic Nematic (ND) and Smectic-G (SmG) phases. The mixture exhibits N+I, N and SmG phases at different concentrations and at different temperatures. Mixtures with all concentrations of abietic acid exhibit I→N+I→N→SmG phases sequentially when the specimen is cooled from its isotropic melt. These phases have been characterized by using differential scanning calorimetric, X-ray diffraction, and optical texture studies.