Sample records for regulating morphopathogenic determinants

  1. 40 CFR 180.2010 - Threshold of regulation determinations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Threshold of regulation determinations... Requiring a Tolerance or an Exemption From a Tolerance § 180.2010 Threshold of regulation determinations... on EPA's determination that the uses are below the threshold of regulation. Pesticide Chemical CAS...

  2. 40 CFR 180.2010 - Threshold of regulation determinations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Threshold of regulation determinations... Requiring a Tolerance or an Exemption From a Tolerance § 180.2010 Threshold of regulation determinations... on EPA's determination that the uses are below the threshold of regulation. Pesticide Chemical CAS...

  3. 40 CFR 180.2010 - Threshold of regulation determinations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Threshold of regulation determinations... Requiring a Tolerance or an Exemption From a Tolerance § 180.2010 Threshold of regulation determinations... on EPA's determination that the uses are below the threshold of regulation. Pesticide Chemical CAS...

  4. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security Administration...

  5. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security Administration...

  6. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security Administration...

  7. Group Guidance Services with Self-Regulation Technique to Improve Student Learning Motivation in Junior High School (JHS)

    ERIC Educational Resources Information Center

    Pranoto, Hadi; Atieka, Nurul; Wihardjo, Sihadi Darmo; Wibowo, Agus; Nurlaila, Siti; Sudarmaji

    2016-01-01

    This study aims at: determining students motivation before being given a group guidance with self-regulation technique, determining students' motivation after being given a group counseling with self-regulation technique, generating a model of group counseling with self-regulation technique to improve motivation of learning, determining the…

  8. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a child's disability determination is...' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT DETERMINING DISABILITY Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a...

  9. 48 CFR 47.304 - Determination of delivery terms.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Determination of delivery terms. 47.304 Section 47.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.304 Determination of delivery...

  10. 48 CFR 225.872-4 - Individual determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Individual determinations. 225.872-4 Section 225.872-4 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... and Coordination 225.872-4 Individual determinations. If the offer of an end product from a qualifying...

  11. 48 CFR 22.1007 - Requirement to obtain wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirement to obtain wage determinations. 22.1007 Section 22.1007 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Amended 22.1007 Requirement to obtain wage determinations. The contracting officer shall obtain wage...

  12. 48 CFR 1.703 - Class determinations and findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... findings. 1.703 Section 1.703 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.703 Class determinations and findings... identical justification. (b) The findings in a class D&F shall fully support the proposed action either for...

  13. Motivational "spill-over" during weight control: increased self-determination and exercise intrinsic motivation predict eating self-regulation.

    PubMed

    Mata, Jutta; Silva, Marlene N; Vieira, Paulo N; Carraça, Eliana V; Andrade, Ana M; Coutinho, Sílvia R; Sardinha, Luis B; Teixeira, Pedro J

    2009-11-01

    Successful weight management relies on at least two health behaviors, eating and exercise. However, little is known about their interaction on a motivational and behavioral level. Based on the Hierarchical Model of Motivation the authors examined whether exercise-specific motivation can transfer to eating regulation during a lifestyle weight control program. The authors further investigated whether general, treatment-related, and exercise motivation underlie the relation between increased exercise and improved eating regulation. Overweight/obese women participated in a 1-year randomized controlled trial (N = 239). The intervention focused on promoting physical activity and internal motivation for exercise and weight loss, following Self-Determination Theory. The control group received general health education. General and exercise specific self-determination, eating self-regulation variables, and physical activity behavior. General self-determination and more autonomous exercise motivation predicted eating self-regulation over 12 months. Additionally, general and exercise self-determination fully mediated the relation between physical activity and eating self-regulation. Increased general self-determination and exercise motivation seem to facilitate improvements in eating self-regulation during weight control in women. These motivational mechanisms also underlie the relationship between improvements in exercise behavior and eating regulation. PsycINFO Database Record (c) 2009 APA, all rights reserved.

  14. RpiRc Is a Pleiotropic Effector of Virulence Determinant Synthesis and Attenuates Pathogenicity in Staphylococcus aureus

    PubMed Central

    Wirf, Jessica; Wonnenberg, B.; Biegel, Tanja; Eisenbeis, J.; Graham, J.; Herrmann, M.; Lee, C. Y.; Beisswenger, C.; Wolz, C.; Tschernig, T.; Bischoff, M.; Somerville, G. A.

    2016-01-01

    In Staphylococcus aureus, metabolism is intimately linked with virulence determinant biosynthesis, and several metabolite-responsive regulators have been reported to mediate this linkage. S. aureus possesses at least three members of the RpiR family of transcriptional regulators. Of the three RpiR homologs, RpiRc is a potential regulator of the pentose phosphate pathway, which also regulates RNAIII levels. RNAIII is the regulatory RNA of the agr quorum-sensing system that controls virulence determinant synthesis. The effect of RpiRc on RNAIII likely involves other regulators, as the regulators that bind the RNAIII promoter have been intensely studied. To determine which regulators might bridge the gap between RpiRc and RNAIII, sarA, sigB, mgrA, and acnA mutations were introduced into an rpiRc mutant background, and the effects on RNAIII were determined. Additionally, phenotypic and genotypic differences were examined in the single and double mutant strains, and the virulence of select strains was examined using two different murine infection models. The data suggest that RpiRc affects RNAIII transcription and the synthesis of virulence determinants in concert with σB, SarA, and the bacterial metabolic status to negatively affect virulence. PMID:27113358

  15. Self-determined to exercise? Leisure-time exercise behavior, exercise motivation, and exercise dependence in youth.

    PubMed

    Symons Downs, Danielle; Savage, Jennifer S; DiNallo, Jennifer M

    2013-02-01

    Scant research has examined the determinants of primary exercise dependence symptoms in youth. Study purposes were to examine sex differences across leisure-time exercise behavior, motivation, and primary exercise dependence symptoms in youth and the extent to which exercise behavior and motivation predicted exercise dependence within the Self-Determination Theory framework. Adolescents (N = 805; mean age = 15 years; 46% girls) completed measures of exercise behavior, motivation, and exercise dependence in health/PE classes. One-way ANOVA revealed boys scored higher than girls on leisure-time exercise behavior, exercise dependence symptoms, and most of the exercise motivation subscales. Hierarchical regression analyses indicated a) sex, exercise behavior, motivation, and their interaction terms explained 39% of the variance in primary exercise dependence; b) Integrated Regulation and Introjected Regulation were important determinants of exercise dependence; and c) sex moderated the contributions of External Regulation for predicting exercise dependence such that boys in the high and low external regulation groups had higher symptoms than girls in the high and low external regulation groups. These preliminary findings support the controlled dimensions of Integrated Regulation (boys, girls), Introjected Regulation (boys, girls), and External Regulation (boys only) are important determinants of primary exercise dependence symptoms.

  16. Retinal Determination genes function along with cell-cell signals to regulate Drosophila eye development: examples of multi-layered regulation by Master Regulators

    PubMed Central

    Baker, Nicholas E.; Firth, Lucy C.

    2015-01-01

    It is thought that Retinal Determination gene products define the response made to cell-cell signals within the eye developmental field by binding to enhancers of genes that are also regulated by cell-cell signaling pathways. In Drosophila, Retinal Determination genes including Eyeless, teashirt, eyes absent, dachsous and sine oculis, are required for normal eye development and can induce ectopic eyes when mis-expressed. Characterization of the enhancers responsible for eye expression of the hedgehog, shaven, and atonal genes, as well as the dynamics of Retinal Determination gene expression themselves, now suggest a multilayered network whereby transcriptional regulation by either Retinal Determination genes or cell-cell signaling pathways can sometimes be indirect and mediated by other transcription factor intermediates. In this updated view of the interaction between extracellular information and cell intrinsic programs during development, regulation of individual genes might sometimes be several steps removed from either the Retinal Determination genes or cell-cell signaling pathways that nevertheless govern their expression. PMID:21607995

  17. 77 FR 14480 - Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... acquisitions made pursuant to Federal Acquisition Regulation (FAR) 12.102(f)(1).'' This language clarifies that... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 212 RIN 0750-AH61 Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case 2011-D041) AGENCY...

  18. 78 FR 13307 - Dow AgroSciences LLC; Availability of Petition for Determination of Nonregulated Status of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... regulated article under APHIS' regulations in 7 CFR part 340. As described in the petition, soybean event... pests. Such genetically engineered (GE) organisms and products are considered ``regulated articles... Health Inspection Service (APHIS) seeking a determination that an article should not be regulated under 7...

  19. 49 CFR 385.805 - Events triggering issuance of remedial directive and proposed determination of unfitness.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... accordance with this subpart for threshold rate violations of any appendix C regulation or regulations that... determination of one or more threshold rate violations of any appendix C regulation are discovered. ...

  20. 48 CFR 617.503 - Determination and findings requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Determination and findings requirements. 617.503 Section 617.503 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING....503 Determination and findings requirements. The authority to make the determination prescribed in FAR...

  1. 48 CFR 242.705-1 - Contracting officer determination procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracting officer determination procedure. 242.705-1 Section 242.705-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES...

  2. 77 FR 41359 - Monsanto Co.; Availability of Petition for Determination of Nonregulated Status of Maize...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... article under APHIS' regulations in 7 CFR part 340. As described in the petition, maize event MON 87427... products are considered ``regulated articles.'' The regulations in Sec. 340.6(a) provide that any person... determination that an article should not be regulated under 7 CFR part 340. Paragraphs (b) and (c) of Sec. 340.6...

  3. Facilitating internalization: the self-determination theory perspective.

    PubMed

    Deci, E L; Eghrari, H; Patrick, B C; Leone, D R

    1994-03-01

    Self-determination theory (Deci & Ryan, 1985) posits that (a) people are inherently motivated to internalize the regulation of uninteresting though important activities; (b) there are two different processes through which such internalization can occur, resulting in qualitatively different styles of self-regulation; and (c) the social context influences which internalization process and regulatory style occur. The two types of internalization are introjection, which entails taking in a value or regulatory process but not accepting it as one's own, and integration, through which the regulation is assimilated with one's core sense of self. Introjection results in internally controlling regulation, whereas integration results in self-determination. An experiment supported our hypothesis that three facilitating contextual factors--namely, providing a meaningful rationale, acknowledging the behaver's feelings, and conveying choice--promote internalization, as evidenced by the subsequent self-regulation of behavior. This experiment also supported our expectation that when the social context supports self-determination, integration tends to occur, whereas when the context does not support self-determination, introjection tends to occur.

  4. 48 CFR 701.704 - Content.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Content. 701.704 Section 701.704 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Determinations and Findings 701.704 Content. There is no USAID-prescribed format or form for determinations and findings...

  5. 48 CFR 701.704 - Content.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Content. 701.704 Section 701.704 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Determinations and Findings 701.704 Content. There is no USAID-prescribed format or form for determinations and findings...

  6. 48 CFR 701.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Content. 701.704 Section 701.704 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Determinations and Findings 701.704 Content. There is no USAID-prescribed format or form for determinations and findings...

  7. 48 CFR 701.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2006-10-01

    ... 48 Federal Acquisition Regulations System 5 2006-10-01 2006-10-01 false Content. 701.704 Section 701.704 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Determinations and Findings 701.704 Content. There is no USAID-prescribed format or form for determinations and findings...

  8. 48 CFR 31.201-4 - Determining allocability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Determining allocability. 31.201-4 Section 31.201-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... for the contract; (b) Benefits both the contract and other work, and can be distributed to them in...

  9. 48 CFR 9.105-2 - Determinations and documentation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Determinations and documentation. 9.105-2 Section 9.105-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION..., including any preaward survey reports, the use of FAPIIS information (see 9.104-6), and any applicable...

  10. 40 CFR 52.977 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Determination of Attainment. Effective March 12, 2010 EPA has determined the Baton Rouge 1-hour ozone nonattainment area has attained the 1-hour ozone National Ambient Air...

  11. 40 CFR 52.977 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Determination of Attainment. Effective March 12, 2010 EPA has determined the Baton Rouge 1-hour ozone nonattainment area has attained the 1-hour ozone National Ambient Air...

  12. 40 CFR 52.977 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Determination of Attainment. Effective March 12, 2010 EPA has determined the Baton Rouge 1-hour ozone nonattainment area has attained the 1-hour ozone National Ambient Air...

  13. 40 CFR 52.977 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. Determination of Attainment. Effective March 12, 2010 EPA has determined the Baton Rouge 1-hour ozone nonattainment area has attained the 1-hour ozone National Ambient Air Quality...

  14. 40 CFR 52.282 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Attainment determination. EPA has determined that the Ventura County severe 1-hour ozone nonattainment area attained the 1-hour ozone NAAQS by the applicable attainment date...

  15. 40 CFR 52.282 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Attainment determination. EPA has determined that the Ventura County severe 1-hour ozone nonattainment area attained the 1-hour ozone NAAQS by the applicable attainment date...

  16. 40 CFR 52.282 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Attainment determination. EPA has determined that the Ventura County severe 1-hour ozone nonattainment area attained the 1-hour ozone NAAQS by the applicable attainment date...

  17. 40 CFR 52.282 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Attainment determination. EPA has determined that the Ventura County severe 1-hour ozone nonattainment area attained the 1-hour ozone NAAQS by the applicable attainment date...

  18. 40 CFR 52.282 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Attainment determination. EPA has determined that the Ventura County severe 1-hour ozone nonattainment area attained the 1-hour ozone NAAQS by the applicable attainment date...

  19. 40 CFR 52.977 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Control strategy and regulations: Ozone... and regulations: Ozone. (a) Determination of Attainment. Effective March 12, 2010 EPA has determined the Baton Rouge 1-hour ozone nonattainment area has attained the 1-hour ozone National Ambient Air...

  20. 76 FR 5780 - Determination of Regulated Status of Alfalfa Genetically Engineered for Tolerance to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ...] Determination of Regulated Status of Alfalfa Genetically Engineered for Tolerance to the Herbicide Glyphosate... for tolerance to the herbicide glyphosate based on APHIS' final environmental impact statement. FOR... regulated status of alfalfa genetically engineered for tolerance to the herbicide glyphosate based on an...

  1. 15 CFR 971.210 - Determination whether application is complete for further processing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... complete for further processing. 971.210 Section 971.210 Commerce and Foreign Trade Regulations Relating to... COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR... for further processing. Upon receipt of an application, the Administrator will review it to determine...

  2. 48 CFR 30.202-8 - Subcontractor disclosure statements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontractor disclosure statements. 30.202-8 Section 30.202-8 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... change the determination of the lower-tier CFAO. (b) Any determination that it is impractical to secure a...

  3. 48 CFR 30.202-8 - Subcontractor disclosure statements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Subcontractor disclosure statements. 30.202-8 Section 30.202-8 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... change the determination of the lower-tier CFAO. (b) Any determination that it is impractical to secure a...

  4. 48 CFR 30.202-8 - Subcontractor disclosure statements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Subcontractor disclosure statements. 30.202-8 Section 30.202-8 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... change the determination of the lower-tier CFAO. (b) Any determination that it is impractical to secure a...

  5. 48 CFR 30.202-8 - Subcontractor disclosure statements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Subcontractor disclosure statements. 30.202-8 Section 30.202-8 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... change the determination of the lower-tier CFAO. (b) Any determination that it is impractical to secure a...

  6. 76 FR 32330 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ... information from interested parties to assist DoD in reviewing its existing regulations to determine whether... business community to determine how its regulations can increase efficiency, transparency, and provide... for the periodic review of its existing regulations and reporting obligations. DoD's plan is designed...

  7. 48 CFR 1322.404 - Davis-Bacon Act wage determination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Davis-Bacon Act wage determination. 1322.404 Section 1322.404 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Involving Construction 1322.404 Davis-Bacon Act wage determination. ...

  8. 48 CFR 1422.404 - Davis-Bacon Act wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Davis-Bacon Act wage determinations. 1422.404 Section 1422.404 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... Involving Construction 1422.404 Davis-Bacon Act wage determinations. ...

  9. 40 CFR 65.160 - Performance test and TRE index value determination records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... concentration of TOC or regulated material is determined. (1) Nonflare combustion device. Where an owner or... TOC achieved by the incinerator determined as specified in § 65.158(b)(4), as applicable, or the concentration of regulated material or TOC (parts per million by volume, by compound) determined as specified in...

  10. Contextual Factors for Establishing Nursing Regulation in Iran: A Qualitative Content Analysis

    PubMed Central

    Nejatian, Ahmad; Joulaei, Hassan

    2018-01-01

    ABSTRACT Background: Professional regulation is one of the strategies of the governments which protect the public’s right. Nursing practice is not an exception; hence, it is regulated to protect the public against nursing services’ adverse effects. Although modern nursing in Iran started from 100 years ago, documents show that there was no regulation mechanism for nursing in Iran till 2016. Hence, this study was conducted to illuminate the contextual factors affecting the nursing regulation process in Iran. Methods: To explore the contextual elements of late establishment of nursing registration as an important part of nursing regulation, we applied directed qualitative content analysis. For this purpose, all the historical events and related materials including articles published in scientific journals, gray literature, statements, news articles, and interviews in the period of 2006-2016 were reviewed and analyzed by expert panel and categorized in predetermined groups. Results: Pooled analysis data showed four contributing elements that affected the emerging nursing regulation in Iran. These elements include 1) cultural determinants, 2) structural determinants, 3) situational determinants, and 4) international or exogenous determinants. Conclusion: Nursing regulation is an important health policy issue in Iran which needs to be facilitated by contextual factors. These factors are complicated and country-specific. Political willingness should be accompanied by nursing association willingness to establish and improve nursing regulation. Other researches are recommended to explore actors and process and content of nursing regulation policy in Iran. PMID:29607341

  11. 7 CFR 27.14 - Filing of classification and Micronaire determination requests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Filing of classification and Micronaire determination... STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification Requests § 27.14 Filing of classification and Micronaire determination requests...

  12. 7 CFR 27.14 - Filing of classification and Micronaire determination requests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Filing of classification and Micronaire determination... STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification Requests § 27.14 Filing of classification and Micronaire determination requests...

  13. 7 CFR 27.36 - Classification and Micronaire determinations based on official standards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Classification and Micronaire determinations based on... COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification and Micronaire Determinations § 27.36 Classification and Micronaire...

  14. 7 CFR 27.87 - Fees; classification and Micronaire determination information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Fees; classification and Micronaire determination... STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Costs of Classification and Micronaire § 27.87 Fees; classification and Micronaire determination...

  15. 7 CFR 27.87 - Fees; classification and Micronaire determination information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Fees; classification and Micronaire determination... STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Costs of Classification and Micronaire § 27.87 Fees; classification and Micronaire determination...

  16. 7 CFR 27.36 - Classification and Micronaire determinations based on official standards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Classification and Micronaire determinations based on... COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification and Micronaire Determinations § 27.36 Classification and Micronaire...

  17. 48 CFR 232.410 - Findings, determination, and authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Findings, determination, and authorization. 232.410 Section 232.410 Federal Acquisition Regulations System DEFENSE ACQUISITION... for Non-Commercial Items 232.410 Findings, determination, and authorization. If an advance payment...

  18. The Development of Intrinsic Motivation for Physical Activity

    DTIC Science & Technology

    2005-07-01

    are said to maintain an impersonal causality orientation and operate through amotivation . In conclusion, it’s the interaction of variables, the... Amotivation External Regulation Introjected Regulation Integrated Regulation Intrinsic Motivation Unintentional action Factors clearly...Control > > > - 12 determination or autonomy in the situation. It runs from amotivation , in which little self- determination is able to be

  19. 7 CFR 340.6 - Petition for determination of nonregulated status. 11

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... plant metabolism, weediness of the regulated article, impact on the weediness of any other plant with... that an article should not be regulated under this part. A petitioner may supplement, amend, or..., make a determination that the article should not be regulated under 7 CFR part 340. (Signature) A...

  20. 7 CFR 340.6 - Petition for determination of nonregulated status. 11

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... plant metabolism, weediness of the regulated article, impact on the weediness of any other plant with... that an article should not be regulated under this part. A petitioner may supplement, amend, or..., make a determination that the article should not be regulated under 7 CFR part 340. (Signature) A...

  1. 7 CFR 340.6 - Petition for determination of nonregulated status. 11

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... plant metabolism, weediness of the regulated article, impact on the weediness of any other plant with... that an article should not be regulated under this part. A petitioner may supplement, amend, or..., make a determination that the article should not be regulated under 7 CFR part 340. (Signature) A...

  2. 7 CFR 340.6 - Petition for determination of nonregulated status. 11

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... plant metabolism, weediness of the regulated article, impact on the weediness of any other plant with... that an article should not be regulated under this part. A petitioner may supplement, amend, or..., make a determination that the article should not be regulated under 7 CFR part 340. (Signature) A...

  3. 7 CFR 340.6 - Petition for determination of nonregulated status. 11

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... plant metabolism, weediness of the regulated article, impact on the weediness of any other plant with... that an article should not be regulated under this part. A petitioner may supplement, amend, or..., make a determination that the article should not be regulated under 7 CFR part 340. (Signature) A...

  4. Examining the validity of the Academic Motivation Scale by comparing scale construction to self-determination theory.

    PubMed

    Cokley, K O

    2000-04-01

    This study examined the construct validity of the Academic Motivation Scale. Specifically, subscale correlations were examined to assess whether support for a continuum of self-determination would be provided. The three types of Intrinsic Motivation were significantly and positively correlated with each other .67, .62, and .58, while the three types of Extrinsic Motivation were significantly and positively intercorrelated .50, .49, and .45. The former subscales, however, correlated higher with Introjected Regulation than Identified Regulation, suggesting that Introjected Regulation may be indicative of more self-determined behavior than has previously been believed. Also, the Intrinsic Motivation To Accomplish subscale had a stronger relationship with two of the Extrinsic Motivation subscales, Identified Regulation and Introjected Regulation, than did the Extrinsic Motivation subscales with each other. This suggests that the differences between Extrinsic and Intrinsic Motivation are not as obvious as has been believed. Also, contrary to self-determination theory, Amotivation had a stronger negative correlation with Identified Regulation (r = -.31) than with any of the Intrinsic Motivation subscales (rs = -.27, -.19, and -.11).

  5. 48 CFR 22.404-3 - Procedures for requesting wage determinations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Procedures for requesting wage determinations. 22.404-3 Section 22.404-3 Federal Acquisition Regulations System FEDERAL...: Branch of Construction Contract Wage Determinations, 200 Constitution Avenue, NW, Washington, DC 20210...

  6. 48 CFR 22.404-3 - Procedures for requesting wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedures for requesting wage determinations. 22.404-3 Section 22.404-3 Federal Acquisition Regulations System FEDERAL...: Branch of Construction Contract Wage Determinations, 200 Constitution Avenue, NW, Washington, DC 20210...

  7. 49 CFR 385.11 - Notification of safety fitness determination.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Notification of safety fitness determination. 385.11 Section 385.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... REGULATIONS SAFETY FITNESS PROCEDURES General § 385.11 Notification of safety fitness determination. (a) The...

  8. 49 CFR 385.11 - Notification of safety fitness determination.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Notification of safety fitness determination. 385.11 Section 385.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... REGULATIONS SAFETY FITNESS PROCEDURES General § 385.11 Notification of safety fitness determination. (a) The...

  9. 49 CFR 385.11 - Notification of safety fitness determination.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Notification of safety fitness determination. 385.11 Section 385.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... REGULATIONS SAFETY FITNESS PROCEDURES General § 385.11 Notification of safety fitness determination. (a) The...

  10. 48 CFR 622.404-11 - Wage determination appeals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Wage determination appeals. 622.404-11 Section 622.404-11 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC... Construction 622.404-11 Wage determination appeals. The cognizant contracting activity is the contracting...

  11. 48 CFR 222.1008-1 - Obtaining wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Obtaining wage determinations. 222.1008-1 Section 222.1008-1 Federal Acquisition Regulations System DEFENSE ACQUISITION... ACQUISITIONS Service Contract Act of 1965, as Amended 222.1008-1 Obtaining wage determinations. Follow the...

  12. 7 CFR 28.8 - Classification of cotton; determination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

  13. 7 CFR 28.8 - Classification of cotton; determination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

  14. 7 CFR 28.8 - Classification of cotton; determination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

  15. 7 CFR 28.8 - Classification of cotton; determination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

  16. 7 CFR 28.8 - Classification of cotton; determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

  17. 48 CFR 317.503 - Determination and findings requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Determination and findings requirements. 317.503 Section 317.503 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES... Act 317.503 Determination and findings requirements. (a) In addition to the D & F contents specified...

  18. 48 CFR 422.404-6 - Modifications of wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Modifications of wage determinations. 422.404-6 Section 422.404-6 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE... Involving Construction 422.404-6 Modifications of wage determinations. HCA's are authorized to request...

  19. 48 CFR 622.404-6 - Modifications of wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Modifications of wage determinations. 622.404-6 Section 622.404-6 Federal Acquisition Regulations System DEPARTMENT OF STATE... Involving Construction 622.404-6 Modifications of wage determinations. The cognizant contracting activity is...

  20. 48 CFR 22.1008 - Procedures for obtaining wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedures for obtaining wage determinations. 22.1008 Section 22.1008 Federal Acquisition Regulations System FEDERAL ACQUISITION... of 1965, as Amended 22.1008 Procedures for obtaining wage determinations. [71 FR 36933, June 28, 2006] ...

  1. 75 FR 48860 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Transportation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... regulation regarding conflict resolution associated with conformity determinations (COMAR 26.11.26.06). EPA... approves Maryland's regulation regarding conflict resolution associated with conformity determinations...

  2. Relations among school students' self-determined motivation, perceived enjoyment, effort, and physical activity behaviors.

    PubMed

    Zhang, Tao

    2009-12-01

    Guided by the self-determination theory, the purpose of this study was to examine the predictive strength of self-determined motivation toward motivational outcomes (perceived enjoyment, perceived effort, physical activity behaviors) for 286 middle school students in physical education. Analyses indicated that intrinsic motivation, identified regulation, and introjected regulation were positively related to students' enjoyment, perceived effort, and physical activity, whereas amotivation was negatively associated with students' enjoyment and perceived effort. The findings highlighted the importance of higher self-determined motivation (intrinsic motivation and identified regulation) in students' perceived enjoyment, effort, and physical activity behaviors. This study supports the use of self-determination theory to investigate students' motivational outcomes in school physical education.

  3. 40 CFR 63.4361 - How do I determine the emission capture system efficiency?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... part 51 to determine the mass fraction of TVH liquid input from each regulated material used in the web.... TVHi = Mass fraction of TVH in regulated material, i, that is applied in the web coating/printing or... the mass of liquid TVH in regulated materials applied in the web coating/printing or dyeing/finishing...

  4. 77 FR 41354 - Monsanto Co.; Availability of Petition for Determination of Nonregulated Status of Soybean...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... ``regulated articles.'' The regulations in Sec. 340.6(a) provide that any person may submit a petition to the Animal and Plant Health Inspection Service (APHIS) seeking a determination that an article should not be... unlikely to pose a plant pest risk and, therefore, should not be a regulated article under APHIS...

  5. 48 CFR 22.1002-2 - Wage determinations based on prevailing rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Wage determinations based on prevailing rates. 22.1002-2 Section 22.1002-2 Federal Acquisition Regulations System FEDERAL... Contract Act of 1965, as Amended 22.1002-2 Wage determinations based on prevailing rates. Contractors...

  6. 48 CFR 22.1002-3 - Wage determinations based on collective bargaining agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Wage determinations based on collective bargaining agreements. 22.1002-3 Section 22.1002-3 Federal Acquisition Regulations... ACQUISITIONS Service Contract Act of 1965, as Amended 22.1002-3 Wage determinations based on collective...

  7. 25 CFR 900.50 - What Federal laws, regulations, and Executive Orders apply to subcontractors?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management..., regulations, and Executive Orders apply to subcontracts awarded under self-determination contracts. As a... Indian Self-Determination Act funds and that the recipient is responsible for identifying and ensuring...

  8. 25 CFR 900.50 - What Federal laws, regulations, and Executive Orders apply to subcontractors?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management..., regulations, and Executive Orders apply to subcontracts awarded under self-determination contracts. As a... Indian Self-Determination Act funds and that the recipient is responsible for identifying and ensuring...

  9. 25 CFR 900.50 - What Federal laws, regulations, and Executive Orders apply to subcontractors?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management..., regulations, and Executive Orders apply to subcontracts awarded under self-determination contracts. As a... Indian Self-Determination Act funds and that the recipient is responsible for identifying and ensuring...

  10. 25 CFR 900.50 - What Federal laws, regulations, and Executive Orders apply to subcontractors?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management..., regulations, and Executive Orders apply to subcontracts awarded under self-determination contracts. As a... Indian Self-Determination Act funds and that the recipient is responsible for identifying and ensuring...

  11. 25 CFR 900.50 - What Federal laws, regulations, and Executive Orders apply to subcontractors?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management..., regulations, and Executive Orders apply to subcontracts awarded under self-determination contracts. As a... Indian Self-Determination Act funds and that the recipient is responsible for identifying and ensuring...

  12. 7 CFR 981.60 - Determination of kernel weight.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Determination of kernel weight. 981.60 Section 981.60... Regulating Handling Volume Regulation § 981.60 Determination of kernel weight. (a) Almonds for which settlement is made on kernel weight. All lots of almonds, whether shelled or unshelled, for which settlement...

  13. 48 CFR 2915.405-70 - Determining fair and reasonable price.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Determining fair and reasonable price. 2915.405-70 Section 2915.405-70 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 2915.405-70 Determining...

  14. 48 CFR 1422.404-6 - Modifications of wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Modifications of wage determinations. 1422.404-6 Section 1422.404-6 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... Involving Construction 1422.404-6 Modifications of wage determinations. The HCA is authorized to request an...

  15. 76 FR 31271 - Public Meeting: Preliminary Regulatory Determinations for the Third Contaminant Candidate List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... Regulatory Determinations for the Third Contaminant Candidate List (CCL 3) AGENCY: Environmental Protection... require the EPA to determine every five years, whether to regulate at least five contaminants from the current Contaminant Candidate List (CCL) with a national primary drinking water regulation. The process of...

  16. Conditionally Active Min-Max Limit Regulators

    NASA Technical Reports Server (NTRS)

    Garg, Sanjay (Inventor); May, Ryan D. (Inventor)

    2017-01-01

    A conditionally active limit regulator may be used to regulate the performance of engines or other limit regulated systems. A computing system may determine whether a variable to be limited is within a predetermined range of a limit value as a first condition. The computing system may also determine whether a current rate of increase or decrease of the variable to be limited is great enough that the variable will reach the limit within a predetermined period of time with no other changes as a second condition. When both conditions are true, the computing system may activate a simulated or physical limit regulator.

  17. Genetic regulation of maize flower development and sex determination.

    PubMed

    Li, Qinglin; Liu, Baoshen

    2017-01-01

    The determining process of pistil fate are central to maize sex determination, mainly regulated by a genetic network in which the sex-determining genes SILKLESS 1 , TASSEL SEED 1 , TASSEL SEED 2 and the paramutagenic locus Required to maintain repression 6 play pivotal roles. Maize silks, which emerge from the ear shoot and derived from the pistil, are the functional stigmas of female flowers and play a pivotal role in pollination. Previous studies on sex-related mutants have revealed that sex-determining genes and phytohormones play an important role in the regulation of flower organogenesis. The processes determining pistil fate are central to flower development, where a silk identified gene SILKLESS 1 (SK1) is required to protect pistil primordia from a cell death signal produced by two commonly known genes, TASSEL SEED 1 (TS1) and TASSEL SEED 2 (TS2). In this review, maize flower developmental process is presented together with a focus on important sex-determining mutants and hormonal signaling affecting pistil development. The role of sex-determining genes, microRNAs, phytohormones, and the paramutagenic locus Required to maintain repression 6 (Rmr6), in forming a regulatory network that determines pistil fate, is discussed. Cloning SK1 and clarifying its function were crucial in understanding the regulation network of sex determination. The signaling mechanisms of phytohormones in sex determination are also an important research focus.

  18. 25 CFR 900.148 - How can an Indian tribe or tribal organization secure a determination that a law or regulation...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false How can an Indian tribe or tribal organization secure a determination that a law or regulation has been superseded by the Indian Self-Determination Act, as specified in... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Waiver Procedures § 900.148 How can an Indian tribe or...

  19. 25 CFR 900.148 - How can an Indian tribe or tribal organization secure a determination that a law or regulation...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false How can an Indian tribe or tribal organization secure a determination that a law or regulation has been superseded by the Indian Self-Determination Act, as specified in... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Waiver Procedures § 900.148 How can an Indian tribe or...

  20. 25 CFR 900.148 - How can an Indian tribe or tribal organization secure a determination that a law or regulation...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false How can an Indian tribe or tribal organization secure a determination that a law or regulation has been superseded by the Indian Self-Determination Act, as specified in... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Waiver Procedures § 900.148 How can an Indian tribe or...

  1. 25 CFR 900.148 - How can an Indian tribe or tribal organization secure a determination that a law or regulation...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false How can an Indian tribe or tribal organization secure a determination that a law or regulation has been superseded by the Indian Self-Determination Act, as specified in... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Waiver Procedures § 900.148 How can an Indian tribe or...

  2. 25 CFR 900.148 - How can an Indian tribe or tribal organization secure a determination that a law or regulation...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false How can an Indian tribe or tribal organization secure a determination that a law or regulation has been superseded by the Indian Self-Determination Act, as specified in... SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Waiver Procedures § 900.148 How can an Indian tribe or...

  3. EPA (Environmental Protection Agency) programs and the regulation of carcinogens: Methods and philosophies. Technical report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jackson, M.; Johnson, L.; Kelly, J.

    1988-01-01

    This paper discusses the manner in which the EPA identifies, assesses risk for, and regulates substances determined to cause cancer in humans. The report provides an overall perspective of the carcinogen standard-setting process as it is affected by scientific, legal, and political influences. Discussed are: history and methods of carcinogen regulation; toxicological methods for determining carcinogenicity; the use of human-exposure data to regulate carcinogens; an overview of the agency's system for classifying chemical agents suspected or known to cause cancer; significant Federal court cases and decisions that have influenced attempts by Federal agencies to regulate carcinogens; and factors affecting EPAsmore » regulation of carcinogens.« less

  4. 49 CFR 397.211 - Preemption determination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES Preemption Procedures § 397.211 Preemption determination. (a) Upon...

  5. An Examination of Motivational Regulations, Dispositional Flow and Social Physique Anxiety among College Students for Exercise: A Self-Determination Theory Approach

    ERIC Educational Resources Information Center

    Ersöz, Gözde

    2016-01-01

    Based on self-determination theory (SDT), the main goal of this study is to analyze dispositional flow and social physique anxiety (SPA) that could be predicted by gender, BMI and motivational regulations and to examine motivational regulations, dispositional flow and SPA of college students in terms of stage of change for exercise. Participants…

  6. MOTIVATION INTERNALIZATION AND SIMPLEX STRUCTURE IN SELF-DETERMINATION THEORY.

    PubMed

    Ünlü, Ali; Dettweiler, Ulrich

    2015-12-01

    Self-determination theory, as proposed by Deci and Ryan, postulated different types of motivation regulation. As to the introjected and identified regulation of extrinsic motivation, their internalizations were described as "somewhat external" and "somewhat internal" and remained undetermined in the theory. This paper introduces a constrained regression analysis that allows these vaguely expressed motivations to be estimated in an "optimal" manner, in any given empirical context. The approach was even generalized and applied for simplex structure analysis in self-determination theory. The technique was exemplified with an empirical study comparing science teaching in a classical school class versus an expeditionary outdoor program. Based on a sample of 84 German pupils (43 girls, 41 boys, 10 to 12 years old), data were collected using the German version of the Academic Self-Regulation Questionnaire. The science-teaching format was seen to not influence the pupils' internalization of identified regulation. The internalization of introjected regulation differed and shifted more toward the external pole in the outdoor teaching format. The quantification approach supported the simplex structure of self-determination theory, whereas correlations may disconfirm the simplex structure.

  7. 7 CFR 1250.510 - Determination of Board Membership.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1250.510 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE EGG RESEARCH AND PROMOTION Rules and Regulations General § 1250.510 Determination of Board Membership. (a...

  8. 7 CFR 51.2548 - Average moisture content determination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Average moisture content determination. 51.2548 Section 51.2548 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

  9. 7 CFR 51.2548 - Average moisture content determination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Average moisture content determination. 51.2548 Section 51.2548 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

  10. 7 CFR 51.2548 - Average moisture content determination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Average moisture content determination. 51.2548 Section 51.2548 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

  11. 7 CFR 51.2548 - Average moisture content determination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Average moisture content determination. 51.2548 Section 51.2548 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

  12. 10 CFR 51.31 - Determinations based on environmental assessment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Determinations based on environmental assessment. 51.31 Section 51.31 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations...

  13. 10 CFR 51.31 - Determinations based on environmental assessment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Determinations based on environmental assessment. 51.31 Section 51.31 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations...

  14. 48 CFR 1419.705-2 - Determining the need for a subcontracting plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Determining the need for a subcontracting plan. 1419.705-2 Section 1419.705-2 Federal Acquisition Regulations System DEPARTMENT OF THE... recommendations offered. ...

  15. Exercisers' perceptions of their fitness instructor's interacting style, perceived competence, and autonomy as a function of self-determined regulation to exercise, enjoyment, affect, and exercise frequency.

    PubMed

    Puente, Rogelio; Anshel, Mark H

    2010-02-01

    The primary purpose of the present investigation was to test the hypothesis, derived from Self-Determination Theory (SDT), that an individual's perceived competence and autonomy mediate the relationship between the exercisers' perception of their instructor's interaction style and the exercisers' motivation to exercise. A secondary purpose was to identify the affective and behavioral outcomes derived from self-determined regulation. It was hypothesized that SDT would significantly explain and predict exercise behavior. Participants consisted of 238 college students, 103 males and 135 females (M age = 20.4 years, SD = 2.16), who volunteered to participate in the study. They were asked to complete a battery of questionnaires measuring instructor's interacting style, self-regulation to exercise, perceived autonomy and competence, enjoyment, positive and negative affect, and exercise frequency. Using structural equation modeling with observed variables, the results showed that perceived competence and autonomy mediated the relationship between perceived instructor's interacting style and self-determined regulation. It was also found that self-determined regulation was significantly related to exercise enjoyment, positive affect, and exercise frequency. It was concluded that understanding the motivational factors and emotional and behavioral consequences of physical activity will partially explain an individual's motives to engage regularly in exercise.

  16. 7 CFR 953.41 - Recommendations for regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Recommendations for regulations. 953.41 Section 953.41... SOUTHEASTERN STATES Order Regulating Handling Regulations § 953.41 Recommendations for regulations. (a) It... effect at the time of recommendation. (b) In determining the grades, sizes, and qualities of potatoes or...

  17. 7 CFR 953.41 - Recommendations for regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Recommendations for regulations. 953.41 Section 953.41... SOUTHEASTERN STATES Order Regulating Handling Regulations § 953.41 Recommendations for regulations. (a) It... effect at the time of recommendation. (b) In determining the grades, sizes, and qualities of potatoes or...

  18. Self-Determination and Meaningful Work: Exploring Socioeconomic Constraints.

    PubMed

    Allan, Blake A; Autin, Kelsey L; Duffy, Ryan D

    2016-01-01

    This study examined a model of meaningful work among a diverse sample of working adults. From the perspectives of Self-Determination Theory and the Psychology of Working Framework, we tested a structural model with social class and work volition predicting SDT motivation variables, which in turn predicted meaningful work. Partially supporting hypotheses, work volition was positively related to internal regulation and negatively related to amotivation, whereas social class was positively related to external regulation and amotivation. In turn, internal regulation was positively related to meaningful work, whereas external regulation and amotivation were negatively related to meaningful work. Indirect effects from work volition to meaningful work via internal regulation and amotivation were significant, and indirect effects from social class to meaningful work via external regulation and amotivation were significant. This study highlights the important relations between SDT motivation variables and meaningful work, especially the large positive relation between internal regulation and meaningful work. However, results also reveal that work volition and social class may play critical roles in predicting internal regulation, external regulation, and amotivation.

  19. 48 CFR 3001.7001 - Content.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Content. 3001.7001 Section 3001.7001 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Other Determinations, Waivers, Exceptions, Approvals, Reviews, and...

  20. 48 CFR 3001.7001 - Content.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Content. 3001.7001 Section 3001.7001 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Other Determinations, Waivers, Exceptions, Approvals, Reviews, and...

  1. 48 CFR 3001.7001 - Content.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Content. 3001.7001 Section 3001.7001 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Other Determinations, Waivers, Exceptions, Approvals, Reviews, and...

  2. 48 CFR 3001.7001 - Content.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Content. 3001.7001 Section 3001.7001 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Other Determinations, Waivers, Exceptions, Approvals, Reviews, and...

  3. 48 CFR 3001.7001 - Content.

    Code of Federal Regulations, 2010 CFR

    2004-10-01

    ... 48 Federal Acquisition Regulations System 7 2004-10-01 2004-10-01 false Content. 3001.7001 Section 3001.7001 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Other Determinations, Waivers, Exceptions, Approvals, Reviews, and...

  4. 48 CFR 3001.7001 - Content.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Content. 3001.7001 Section 3001.7001 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Other Determinations, Waivers, Exceptions, Approvals, Reviews, and...

  5. 46 CFR 221.65 - Criteria for determining penalty.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Criteria for determining penalty. 221.65 Section 221.65 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING MARITIME CARRIERS AND RELATED ACTIVITIES REGULATED TRANSACTIONS INVOLVING DOCUMENTED VESSELS AND OTHER MARITIME INTERESTS Civil...

  6. 15 CFR 303.4 - Determination of territorial distribution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Determination of territorial distribution. 303.4 Section 303.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS REGULATIONS WATCHES...

  7. Exercise motivational regulations and exercise addiction: The mediating role of passion.

    PubMed

    Sicilia, Álvaro; Alcaraz-Ibáñez, Manuel; Lirola, María-Jesús; Burgueño, Rafael; Maher, Anthony

    2018-05-23

    Background and aims The study explored the mediating role of forms of passion in the relationship between motivational regulations in exercise and exercise addiction (EA). Methods A total of 485 university students (368 males and 117 females; M age  = 20.43, SD = 3.21) completed a questionnaire measuring the frequency and intensity of exercise, motivational regulations in exercise, passion for exercise, and EA. Controlling the effects of age, frequency, and intensity of practice, the relationships between the study variables were examined though a path analysis. Results Both self-determined and non-self-determined forms of motivation showed positive association with EA. The forms of motivation with greatest predictive power for EA were introjected and integrated regulations. Both forms of motivation had positive direct and indirect effects through obsessive passion (OP) on EA; however, integrated regulation also showed negative indirect effects through harmonious passion on EA. Conclusions Both forms of passion and, especially, OP, seem to affect how motivational regulations are associated with EA. These findings clarify the association found in previous studies between self-determined forms of motivation and EA.

  8. Does intrinsic motivation strengthen physical activity habit? Modeling relationships between self-determination, past behaviour, and habit strength.

    PubMed

    Gardner, Benjamin; Lally, Phillippa

    2013-10-01

    Habit formation is thought to aid maintenance of physical activity, but little research is available into determinants of habit strength aside from repeated performance. Previous work has shown that intrinsically motivated physical activity, underpinned by inherent satisfaction derived from activity, is more likely to be sustained. We explored whether this might reflect a tendency for self-determined activity to become more strongly habitual. A sample of 192 adults aged 18-30 completed measures of motivational regulation, intention, behaviour, and habit strength. Results showed that self-determined regulation interacted with past behaviour in predicting habit strength: prior action was more predictive of habit strength among more autonomously motivated participants. There was an unexpected direct effect of self-determined regulation on habit strength, independently of past behaviour. Findings offer possible directions for future habit formation work.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Yimin; Bhatt, Arpit; Heath, Garvin

    Biorefineries are subject to environmental laws, including complex air quality regulations that aim to protect and improve the quality of the air. These regulations govern the amount of certain types of air pollutants that can be emitted from different types of emission sources. To determine which federal air emission regulations potentially apply to the sugars-to-hydrocarbon (HC) biorefinery, we first identified the types of regulated air pollutants emitted to the ambient environment by the biorefinery or from specific equipment. Once the regulated air pollutants are identified, we review the applicability criteria of each federal air regulation to determine whether the sugars-to-HCmore » biorefinery or specific equipment is subject to it. We then estimate the potential-to-emit of pollutants likely to be emitted from the sugars-to-HC biorefinery to understand the air permitting requirements.« less

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bhatt, Arpit; Zhang, Yimin; Heath, Garvin

    Biorefineries are subject to environmental laws, including complex air quality regulations that aim to protect and improve the quality of the air. These regulations govern the amount of certain types of air pollutants that can be emitted from different types of emission sources. To determine which federal air emission regulations potentially apply to the fast pyrolysis biorefinery, we first identified the types of regulated air pollutants emitted to the ambient environment by the biorefinery or from specific equipment. Once the regulated air pollutants are identified, we review the applicability criteria of each federal air regulation to determine whether the fastmore » pyrolysis biorefinery or specific equipment is subject to it. We then estimate the potential-to-emit of pollutants likely to be emitted from the fast pyrolysis biorefinery to understand the air permitting requirements.« less

  11. Using cluster analysis to examine the combinations of motivation regulations of physical education students.

    PubMed

    Ullrich-French, Sarah; Cox, Anne

    2009-06-01

    According to self-determination theory, motivation is multidimensional, with motivation regulations lying along a continuum of self-determination (Ryan & Deci, 2007). Accounting for the different types of motivation in physical activity research presents a challenge. This study used cluster analysis to identify motivation regulation profiles and examined their utility by testing profile differences in relative levels of self-determination (i.e., self-determination index), and theoretical antecedents (i.e., competence, autonomy, relatedness) and consequences (i.e., enjoyment, worry, effort, value, physical activity) of physical education motivation. Students (N= 386) in 6th- through 8th-grade physical education classes completed questionnaires of the variables listed above. Five profiles emerged, including average (n = 81), motivated (n = 82), self-determined (n = 91), low motivation (n = 73), and external (n = 59). Group difference analyses showed that students with greater levels of self-determined forms of motivation, regardless of non-self-determined motivation levels, reported the most adaptive physical education experiences.

  12. Co-option of the bZIP transcription factor Vrille as the activator of Doublesex1 in environmental sex determination of the crustacean Daphnia magna.

    PubMed

    Mohamad Ishak, Nur Syafiqah; Nong, Quang Dang; Matsuura, Tomoaki; Kato, Yasuhiko; Watanabe, Hajime

    2017-11-01

    Divergence of upstream regulatory pathways of the transcription factor Doublesex (Dsx) serves as a basis for evolution of sex-determining mechanisms in animals. However, little is known about the regulation of Dsx in environmental sex determination. In the crustacean Daphnia magna, environmental sex determination is implemented by male-specific expression of the Dsx ortholog, Dsx1. Transcriptional regulation of Dsx1 comprises at least three phases during embryogenesis: non-sex-specific initiation, male-specific up-regulation, and its maintenance. Herein, we demonstrate that the male-specific up-regulation is controlled by the bZIP transcription factor, Vrille (Vri), an ortholog of the circadian clock genes-Drosophila Vri and mammalian E4BP4/NFIL3. Sequence analysis of the Dsx1 promoter/enhancer revealed a conserved element among two Daphnia species (D. magna and D. pulex), which contains a potential enhancer harboring a consensus Vri binding site overlapped with a consensus Dsx binding site. Besides non-sex-specific expression of Vri in late embryos, we found male-specific expression in early gastrula before the Dsx1 up-regulation phase begins. Knockdown of Vri in male embryos showed reduction of Dsx1 expression. In addition, transient overexpression of Vri in early female embryos up-regulated the expression of Dsx1 and induced male-specific trait. Targeted mutagenesis using CRISPR/Cas9 disrupted the enhancer on genome in males, which led to the reduction of Dsx1 expression. These results indicate that Vri was co-opted as a transcriptional activator of Dsx1 in environmental sex determination of D. magna. The data suggests the remarkably plastic nature of gene regulatory network in sex determination.

  13. Co-option of the bZIP transcription factor Vrille as the activator of Doublesex1 in environmental sex determination of the crustacean Daphnia magna

    PubMed Central

    Nong, Quang Dang; Matsuura, Tomoaki; Watanabe, Hajime

    2017-01-01

    Divergence of upstream regulatory pathways of the transcription factor Doublesex (Dsx) serves as a basis for evolution of sex-determining mechanisms in animals. However, little is known about the regulation of Dsx in environmental sex determination. In the crustacean Daphnia magna, environmental sex determination is implemented by male-specific expression of the Dsx ortholog, Dsx1. Transcriptional regulation of Dsx1 comprises at least three phases during embryogenesis: non-sex-specific initiation, male-specific up-regulation, and its maintenance. Herein, we demonstrate that the male-specific up-regulation is controlled by the bZIP transcription factor, Vrille (Vri), an ortholog of the circadian clock genes—Drosophila Vri and mammalian E4BP4/NFIL3. Sequence analysis of the Dsx1 promoter/enhancer revealed a conserved element among two Daphnia species (D. magna and D. pulex), which contains a potential enhancer harboring a consensus Vri binding site overlapped with a consensus Dsx binding site. Besides non-sex-specific expression of Vri in late embryos, we found male-specific expression in early gastrula before the Dsx1 up-regulation phase begins. Knockdown of Vri in male embryos showed reduction of Dsx1 expression. In addition, transient overexpression of Vri in early female embryos up-regulated the expression of Dsx1 and induced male-specific trait. Targeted mutagenesis using CRISPR/Cas9 disrupted the enhancer on genome in males, which led to the reduction of Dsx1 expression. These results indicate that Vri was co-opted as a transcriptional activator of Dsx1 in environmental sex determination of D. magna. The data suggests the remarkably plastic nature of gene regulatory network in sex determination. PMID:29095827

  14. 7 CFR 301.48-2 - Authorization to designate, and terminate designation of, regulated airports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of, regulated airports. 301.48-2 Section 301.48-2 Agriculture Regulations of the Department of... terminate designation of, regulated airports. (a) An inspector may declare any airport within a quarantined State to be a regulated airport when he or she determines that adult populations of Japanese beetle...

  15. 48 CFR 1.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Content. 1.704 Section 1.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.704 Content. Each D&F shall set forth enough facts and...

  16. 48 CFR 1.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2009-10-01

    ... 48 Federal Acquisition Regulations System 1 2009-10-01 2009-10-01 false Content. 1.704 Section 1.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.704 Content. Each D&F shall set forth enough facts and...

  17. 48 CFR 1.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2005-10-01

    ... 48 Federal Acquisition Regulations System 1 2005-10-01 2005-10-01 false Content. 1.704 Section 1.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.704 Content. Each D&F shall set forth enough facts and...

  18. Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria

    PubMed Central

    RICHARDSON, ANTHONY R.; SOMERVILLE, GREG A.; SONENSHEIN, ABRAHAM L.

    2015-01-01

    Pathogenic bacteria must contend with immune systems that actively restrict the availability of nutrients and cofactors, and create a hostile growth environment. To deal with these hostile environments, pathogenic bacteria have evolved or acquired virulence determinants that aid in the acquisition of nutrients. This connection between pathogenesis and nutrition may explain why regulators of metabolism in nonpathogenic bacteria are used by pathogenic bacteria to regulate both metabolism and virulence. Such coordinated regulation is presumably advantageous because it conserves carbon and energy by aligning synthesis of virulence determinants with the nutritional environment. In Gram-positive bacterial pathogens, at least three metabolite-responsive global regulators, CcpA, CodY, and Rex, have been shown to coordinate the expression of metabolism and virulence genes. In this chapter, we discuss how environmental challenges alter metabolism, the regulators that respond to this altered metabolism, and how these regulators influence the host-pathogen interaction. PMID:26185086

  19. 20 CFR 652.8 - Administrative provisions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... openings, labor market information, and similar items are allowable. (5) Each State shall retain basic... determination. Such determinations shall be based on the requirements of the Act, regulations, and State plan... corrective actions for violation of the Act, regulations, or State plan, including the following: (i...

  20. 20 CFR 652.8 - Administrative provisions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... openings, labor market information, and similar items are allowable. (5) Each State shall retain basic... determination. Such determinations shall be based on the requirements of the Act, regulations, and State plan... corrective actions for violation of the Act, regulations, or State plan, including the following: (i...

  1. 48 CFR 622.404 - Davis-Bacon Act wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Davis-Bacon Act wage determinations. 622.404 Section 622.404 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Labor Standards for Contracts Involving...

  2. 48 CFR 422.404 - Davis-Bacon Act wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Davis-Bacon Act wage determinations. 422.404 Section 422.404 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Labor Standards for Contracts...

  3. 41 CFR 101-5.104-7 - Administrator's determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Administrator's determination. 101-5.104-7 Section 101-5.104-7 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 5-CENTRALIZED SERVICES IN...

  4. 48 CFR 32.203 - Determining contract financing terms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... financing terms. 32.203 Section 32.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Commercial Item Purchase Financing 32.203 Determining contract financing terms. When the criteria in 32.202-1(b) are met, the contracting officer may either...

  5. Motivational Profiles for Physical Activity Practice in Adults with Type 2 Diabetes: A Self-Determination Theory Perspective.

    PubMed

    Gourlan, Mathieu; Trouilloud, David; Boiché, Julie

    2016-01-01

    Drawing on Self-Determination Theory, this study explored the motivational profiles toward Physical Activity (PA) among adults with type 2 diabetes and the relationships between motivational profile, perceived competence and PA. Participants were 350 men and women (Mean age 62.77 years) who were interviewed on their motivations toward PA, perceived level of competence to practice, and PA practice. Cluster analyses reveal the existence of three distinct profiles: "High Combined" (ie, high scores on motivations ranging from intrinsic to external regulation, moderate level on amotivation), "Self-Determined" (ie, high scores on intrinsic, integrated, and identified regulations; low scores on other regulations), and "Moderate" (ie, moderate scores on all regulations). Participants with "High Combined" and "Self-Determined" profiles reported higher perceived competence and longer leisure-time PA practice in comparison to those with a "Moderate" profile. This study highlights the necessity of adopting a person-centered approach to better understand motivation toward PA among type 2 diabetics.

  6. Stirring the motivational soup: within-person latent profiles of motivation in exercise.

    PubMed

    Lindwall, Magnus; Ivarsson, Andreas; Weman-Josefsson, Karin; Jonsson, Linus; Ntoumanis, Nikos; Patrick, Heather; Thøgersen-Ntoumani, Cecilie; Markland, David; Teixeira, Pedro

    2017-01-14

    The purpose of the present study was to use a person-oriented analytical approach to identify latent motivational profiles, based on the different behavioural regulations for exercise, and to examine differences in satisfaction of basic psychological needs (competence, autonomy and relatedness) and exercise behaviour across these motivational profiles. Two samples, consisting of 1084 and 511 adults respectively, completed exercise-related measures of behavioural regulation and psychological need satisfaction as well as exercise behaviour. Latent profile analyses were used to identify motivational profiles. Six profiles, representing different combinations of regulations for exercise, were found to best represent data in both samples. Some profiles were found in both samples (e.g., low motivation profile, self-determined motivation profile and self-determined with high introjected regulation profile), whereas others were unique to each sample. In line with the Self-Determination Theory, individuals belonging to more self-determined profiles demonstrated higher scores on need satisfaction. The results support the notions of motivation being a multidimensional construct and that people have different, sometimes competing, reasons for engaging in exercise. The benefits of using person-oriented analyses to examine within-person interactions of motivation and different regulations are discussed.

  7. Examining exercise dependence symptomatology from a self-determination perspective.

    PubMed

    Edmunds, Jemma; Ntoumanis, Nikos; Duda, Joan L

    2006-11-01

    Background Pulling from Self-Determination Theory (SDT; Deci & Ryan, 1985), this study examined whether individuals classified as 'nondependent-symptomatic' and 'nondependent-asymptomatic' for exercise dependence differed in terms of reported levels of exercise-related psychological need satisfaction, self-determined versus controlling motivation and exercise behavior. In addition, we examined the type of motivational regulations predicting exercise behavior among these different groups, and their role as mediators between psychological need satisfaction and behavioral outcomes. Methods Participants (N = 339) completed measures of exercise-specific psychological need satisfaction, motivational regulations, exercise behavior and exercise dependence. Results Nondependent-symptomatic individuals reported higher levels of competence need satisfaction and all forms of motivational regulation, compared to nondependent-asymptomatic individuals. Introjected regulation approached significance as a positive predictor of strenuous exercise behavior for symptomatic individuals. Identified regulation was a positive predictor of strenuous exercise, and completely mediated the relationship between competence need satisfaction and strenuous exercise behavior, for asymptomatic individuals. Conclusions The findings reinforce the applicability of SDT to understanding the quantity and quality of engagement in exercise.

  8. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  9. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall b...

  10. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  11. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  12. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2004-10-01

    ... 48 Federal Acquisition Regulations System 7 2004-10-01 2004-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  13. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  14. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2006-10-01

    ... 48 Federal Acquisition Regulations System 7 2006-10-01 2006-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  15. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2011 CFR

    2008-10-01

    ... 48 Federal Acquisition Regulations System 7 2008-10-01 2008-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  16. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2011 CFR

    2016-10-01

    ... 48 Federal Acquisition Regulations System 7 2016-10-01 2014-10-01 true Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall b...

  17. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2007-10-01

    ... 48 Federal Acquisition Regulations System 7 2007-10-01 2007-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 3001.704 Content. The following format shall...

  18. The differential effects of intrinsic and identified motivation on well-being and performance: prospective, experimental, and implicit approaches to self-determination theory.

    PubMed

    Burton, Kimberly D; Lydon, John E; D'Alessandro, David U; Koestner, Richard

    2006-10-01

    Self-determination theory research has demonstrated that intrinsic and identified self-regulations are associated with successful adaptation. However, few distinctions are typically made between these regulations and their outcomes. In the present studies, the associations between intrinsic and identified motivations and outcomes of psychological well-being and academic performance are compared in educational settings. In Study 1, intrinsic self-regulation predicted psychological well-being, independent of academic performance. In contrast, identified regulation predicted academic performance. Additionally, the more that students demonstrated an identified academic regulation, the more that their psychological well-being was contingent on performance. In Study 2a, priming intrinsic self-regulation led to greater psychological well-being 10 days later. In Study 2b, an implicit measure of identified regulation predicted academic performance 6 weeks later. Results indicate the need to address important distinctions between intrinsic and identified regulations. 2006 APA, all rights reserved

  19. Plant Nitrogen Acquisition Under Low Availability: Regulation of Uptake and Root Architecture

    PubMed Central

    Kiba, Takatoshi; Krapp, Anne

    2016-01-01

    Nitrogen availability is a major factor determining plant growth and productivity. Plants acquire nitrogen nutrients from the soil through their roots mostly in the form of ammonium and nitrate. Since these nutrients are scarce in natural soils, plants have evolved adaptive responses to cope with the environment. One of the most important responses is the regulation of nitrogen acquisition efficiency. This review provides an update on the molecular determinants of two major drivers of the nitrogen acquisition efficiency: (i) uptake activity (e.g. high-affinity nitrogen transporters) and (ii) root architecture (e.g. low-nitrogen-availability-specific regulators of primary and lateral root growth). Major emphasis is laid on the regulation of these determinants by nitrogen supply at the transcriptional and post-transcriptional levels, which enables plants to optimize nitrogen acquisition efficiency under low nitrogen availability. PMID:27025887

  20. 77 FR 56533 - Property Traded on an Established Market

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... Property Traded on an Established Market AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Final regulations. SUMMARY: This document contains final regulations that apply to determine when property is traded on an established market (that is, publicly traded) for purposes of determining the issue price of a...

  1. 48 CFR 942.705-1 - Contracting officer determination procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting officer determination procedure. 942.705-1 Section 942.705-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 942.705-1 Contracting...

  2. Space shuttle OMS helium regulator design and development

    NASA Technical Reports Server (NTRS)

    Wichmann, H.; Kelly, T. L.; Lynch, R.

    1974-01-01

    Analysis, design, fabrication and design verification testing was conducted on the technological feasiblity of the helium pressurization regulator for the space shuttle orbital maneuvering system application. A prototype regulator was fabricated which was a single-stage design featuring the most reliable and lowest cost concept. A tradeoff study on regulator concepts indicated that a single-stage regulator with a lever arm between the valve and the actuator section would offer significant weight savings. Damping concepts were tested to determine the amount of damping required to restrict actuator travel during vibration. Component design parameters such as spring rates, effective area, contamination cutting, and damping were determined by test prior to regulator final assembly. The unit was subjected to performance testing at widely ranging flow rates, temperatures, inlet pressures, and random vibration levels. A test plan for propellant compatibility and extended life tests is included.

  3. 26 CFR 1.852-6 - Records to be kept for purpose of determining whether a corporation claiming to be a regulated...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TAX (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment... whether a corporation claiming to be a regulated investment company is a personal holding company. 1.852-6... regulated investment company is a personal holding company. (a) Every regulated investment company shall...

  4. 26 CFR 1.852-6 - Records to be kept for purpose of determining whether a corporation claiming to be a regulated...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TAX (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment... whether a corporation claiming to be a regulated investment company is a personal holding company. 1.852-6... regulated investment company is a personal holding company. (a) Every regulated investment company shall...

  5. 26 CFR 1.852-6 - Records to be kept for purpose of determining whether a corporation claiming to be a regulated...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TAX (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment... whether a corporation claiming to be a regulated investment company is a personal holding company. 1.852-6... regulated investment company is a personal holding company. (a) Every regulated investment company shall...

  6. The importance of self-determined motivation towards physical activity in patients with schizophrenia.

    PubMed

    Vancampfort, Davy; De Hert, Marc; Vansteenkiste, Maarten; De Herdt, Amber; Scheewe, Thomas W; Soundy, Andrew; Stubbs, Brendon; Probst, Michel

    2013-12-30

    There is a need for theoretically-based research on the motivational processes linked to the commencement and continuation of physical activity in patients with schizophrenia. Within the Self-Determination Theory (SDT) framework, we investigated the SDT tenets in these patients by examining the factor structure of the Behavioral Regulation in Exercise Questionnaire-2 (BREQ-2) and by investigating associations between motivation and PA. The secondary aim was to study differences in motivation according to gender, educational level, treatment setting and disease stage. A total of 129 patients (44♀) with schizophrenia agreed to participate. Exploratory factor analysis showed sufficient convergence with the original factor for amotivation, external and introjected regulation, while identified and intrinsic regulations loaded on a single factor which we labeled "autonomous regulation". Significant positive correlations were found between the total physical activity score and the subscales amotivation (r = -0.44, P < 0.001), external regulation (r = -0.27, P < 0.001), and autonomous regulation (r = 0.57, P < 0.001). Outpatients reported more external (P < 0.05) and introjected (P < 0.05) regulations than inpatients. Our results suggest that patients' level of self-determination may play an important role in the adoption and maintenance of health promoting behaviors in patients with schizophrenia. © 2013 Published by Elsevier Ireland Ltd.

  7. 5 CFR 339.103 - Compliance with EEOC regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Compliance with EEOC regulations. 339.103 Section 339.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS General § 339.103 Compliance with EEOC regulations. Actions under this part must be...

  8. 5 CFR 339.103 - Compliance with EEOC regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Compliance with EEOC regulations. 339.103 Section 339.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS General § 339.103 Compliance with EEOC regulations. Actions under this part must be...

  9. 5 CFR 339.103 - Compliance with EEOC regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Compliance with EEOC regulations. 339.103 Section 339.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS General § 339.103 Compliance with EEOC regulations. Actions under this part must be...

  10. 5 CFR 339.103 - Compliance with EEOC regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Compliance with EEOC regulations. 339.103 Section 339.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS General § 339.103 Compliance with EEOC regulations. Actions under this part must be...

  11. 5 CFR 339.103 - Compliance with EEOC regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Compliance with EEOC regulations. 339.103 Section 339.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS General § 339.103 Compliance with EEOC regulations. Actions under this part must be...

  12. Self-Determination and Meaningful Work: Exploring Socioeconomic Constraints

    PubMed Central

    Allan, Blake A.

    2016-01-01

    This study examined a model of meaningful work among a diverse sample of working adults. From the perspectives of Self-Determination Theory and the Psychology of Working Framework, we tested a structural model with social class and work volition predicting SDT motivation variables, which in turn predicted meaningful work. Partially supporting hypotheses, work volition was positively related to internal regulation and negatively related to amotivation, whereas social class was positively related to external regulation and amotivation. In turn, internal regulation was positively related to meaningful work, whereas external regulation and amotivation were negatively related to meaningful work. Indirect effects from work volition to meaningful work via internal regulation and amotivation were significant, and indirect effects from social class to meaningful work via external regulation and amotivation were significant. This study highlights the important relations between SDT motivation variables and meaningful work, especially the large positive relation between internal regulation and meaningful work. However, results also reveal that work volition and social class may play critical roles in predicting internal regulation, external regulation, and amotivation. PMID:26869970

  13. Motivational dynamics of eating regulation: a self-determination theory perspective

    PubMed Central

    2012-01-01

    Within Western society, many people have difficulties adequately regulating their eating behaviors and weight. Although the literature on eating regulation is vast, little attention has been given to motivational dynamics involved in eating regulation. Grounded in Self-Determination Theory (SDT), the present contribution aims to provide a motivational perspective on eating regulation. The role of satisfaction and thwarting of the basic psychological needs for autonomy, competence, and relatedness is introduced as a mechanism to (a) explain the etiology of body image concerns and disordered eating and (b) understand the optimal regulation of ongoing eating behavior for healthy weight maintenance. An overview of empirical studies on these two research lines is provided. In a final section, the potential relevance and value of SDT in relation to prevailing theoretical models in the domain of eating regulation is discussed. Although research on SDT in the domain of eating regulation is still in its early stages and more research is clearly needed, this review suggests that the SDT represents a promising framework to more thoroughly study and understand the motivational processes involved in eating regulation and associated problems. PMID:22385782

  14. Motivational profiles in physical education and their relation to the theory of planned behavior.

    PubMed

    Moreno-Murcia, Juan Antonio; Cervelló Gimeno, Eduardo; Hernández, Elisa Huéscar; Pedreño, Noelia Belan-do; Rodríguez Marín, Jesús Jesus

    2013-01-01

    The aim of this study was to establish motivational profiles for doing physical activity according to the variables from the theory of planned action in a sample of 698 students aged 14 to 16. The instruments used were the Questionnaire of Behavioral Regulation in Sport (BRQ-R) and the Questionnaire of the Theory of Planned Behavior (TCP). Cluster analysis revealed two motivational profiles: a "self-determined "profile with high scores in intrinsic motivation and low scores in extrinsic motivation and amotivation, and a "non self- determined "profile with low scores in intrinsic motivation and high scores in extrinsic motivation and amotivation. Positive significant differences in attitudes, norms, and intent to control were found for the self-determined profile related to "non self-determined "profile. Key PointsA "self-determined "profile was found with higher scores for the four types of intrinsic motivations (general, knowledge, stimulation and achievement) and identified regulation than for introjected and external regulation.A "non self-determined "profile was found with higher scores for external, introjected regulation and amotivation than for the four types of intrinsic motivation (general, knowledge, stimulation and achievement).In the context of the "non self-determined profile "we could encourage programs that adapt to these needs in such a way that they contribute to increasing the rates of doing physical activity in the population.

  15. 78 FR 59219 - Stress Testing of Regulated Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... FEDERAL HOUSING FINANCE AGENCY 12 CFR Part 1238 RIN 2590-AA47 Stress Testing of Regulated Entities... assets of more than $10 billion to conduct annual stress tests to determine whether the companies have... federal financial regulatory agency, to conduct annual stress tests to determine whether the companies...

  16. 15 CFR 782.4 - Assistance in determining your obligations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Assistance in determining your obligations. 782.4 Section 782.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL...

  17. 5 CFR 2426.12 - Requests; petition and procedures for determination of eligibility for consultation rights on...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... determination of eligibility for consultation rights on Government-wide rules or regulations. 2426.12 Section... GENERAL COUNSEL OF THE FEDERAL LABOR RELATIONS AUTHORITY NATIONAL CONSULTATION RIGHTS AND CONSULTATION RIGHTS ON GOVERNMENT-WIDE RULES OR REGULATIONS Consultation Rights on Government-wide Rules or...

  18. 7 CFR 929.102 - Procedure to determine quantity of screened cranberries in unscreened lots.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... cranberries in unscreened lots. 929.102 Section 929.102 Agriculture Regulations of the Department of..., Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF MASSACHUSETTS, RHODE ISLAND... NEW YORK Rules and Regulations § 929.102 Procedure to determine quantity of screened cranberries in...

  19. 7 CFR 929.102 - Procedure to determine quantity of screened cranberries in unscreened lots.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... cranberries in unscreened lots. 929.102 Section 929.102 Agriculture Regulations of the Department of..., NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF MASSACHUSETTS, RHODE ISLAND... NEW YORK Rules and Regulations § 929.102 Procedure to determine quantity of screened cranberries in...

  20. 7 CFR 929.102 - Procedure to determine quantity of screened cranberries in unscreened lots.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... cranberries in unscreened lots. 929.102 Section 929.102 Agriculture Regulations of the Department of..., NUTS), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF MASSACHUSETTS, RHODE ISLAND... NEW YORK Rules and Regulations § 929.102 Procedure to determine quantity of screened cranberries in...

  1. 7 CFR 929.102 - Procedure to determine quantity of screened cranberries in unscreened lots.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... cranberries in unscreened lots. 929.102 Section 929.102 Agriculture Regulations of the Department of..., Nuts), DEPARTMENT OF AGRICULTURE CRANBERRIES GROWN IN STATES OF MASSACHUSETTS, RHODE ISLAND... NEW YORK Rules and Regulations § 929.102 Procedure to determine quantity of screened cranberries in...

  2. 7 CFR 27.64 - Application for review of classification and for Micronaire determination; filing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Application for review of classification and for... AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification Reviews and Micronaire Determinations § 27.64 Application for review of...

  3. 7 CFR 27.64 - Application for review of classification and for Micronaire determination; filing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Application for review of classification and for... AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification Reviews and Micronaire Determinations § 27.64 Application for review of...

  4. Effect of growth regulators, boron and molybdenum on sugarcane grown in the greenhouse

    USDA-ARS?s Scientific Manuscript database

    Tillering is an important characteristic in determining sugarcane yields. An experiment was conducted in the greenhouse using LCP 85-384 to determine the influence of the growth regulator Moddus, alone and in all possible combinations with boron and molybdenum, on the growth and development of young...

  5. 48 CFR 19.202-6 - Determination of fair market price.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... market price. 19.202-6 Section 19.202-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-6 Determination of fair market price. (a) The fair market price shall be the price achieved in accordance with the reasonable price...

  6. 15 CFR 738.4 - Determining whether a license is required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Determining whether a license is required. 738.4 Section 738.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

  7. 40 CFR 180.2010 - Threshold of regulation determinations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Threshold of regulation determinations. 180.2010 Section 180.2010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From...

  8. 40 CFR 180.2010 - Threshold of regulation determinations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Threshold of regulation determinations. 180.2010 Section 180.2010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From...

  9. Choice and ego-depletion: the moderating role of autonomy.

    PubMed

    Moller, Arlen C; Deci, Edward L; Ryan, Richard M

    2006-08-01

    The self-regulatory strength model maintains that all acts of self-regulation, self-control, and choice result in a state of fatigue called ego-depletion. Self-determination theory differentiates between autonomous regulation and controlled regulation. Because making decisions represents one instance of self-regulation, the authors also differentiate between autonomous choice and controlled choice. Three experiments support the hypothesis that whereas conditions representing controlled choice would be egodepleting, conditions that represented autonomous choice would not. In Experiment 3, the authors found significant mediation by perceived self-determination of the relation between the choice condition (autonomous vs. controlled) and ego-depletion as measured by performance.

  10. 48 CFR 1.704 - Content.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Content. 1.704 Section 1.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.704 Content. Each D&F shall set forth enough facts and circumstances to clearly and convincingly...

  11. 48 CFR 1.704 - Content.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Content. 1.704 Section 1.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.704 Content. Each D&F shall set forth enough facts and circumstances to clearly and convincingly...

  12. 48 CFR 1.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Content. 1.704 Section 1.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.704 Content. Each D&F shall set forth enough facts and circumstances to clearly and convincingly...

  13. 48 CFR 1.704 - Content.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Content. 1.704 Section 1.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Determinations and Findings 1.704 Content. Each D&F shall set forth enough facts and circumstances to clearly and convincingly...

  14. 76 FR 70220 - New Jersey Regulations on Transportation of Regulated Medical Waste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    .... PHMSA-2011-0294 (PDA-35(R)] New Jersey Regulations on Transportation of Regulated Medical Waste AGENCY... administrative determination is issued by PHMSA's Chief Counsel. Rebuttal comments may discuss only those issues...: The Institute's application and all comments received may be reviewed in the Docket Operations...

  15. Determinants Affecting Physical Activity Levels In Animal Models

    NASA Technical Reports Server (NTRS)

    Tou, Janet C. L.; Wade, Charles E.; Dalton, Bonnie P. (Technical Monitor)

    2001-01-01

    Weight control is dependent on energy balance. Reduced energy expenditure (EE) associated with decreased physical activity is suggested to be a major underlying cause in the increasing prevalence of weight gain and obesity. Therefore, a better understanding of the biological determinants involved in the regulation of physical activity is essential. To facilitate interpretation in humans, it is helpful to consider the evidence from animal studies. This review focuses on animal studies examining the biological determinants influencing activity and potential implications to human. It appears that physical activity is influenced by a number of parameters. However, regardless of the parameter involved, body weight appears to play all underlying role in the regulation of activity. Furthermore, the regulation of activity associated with body weight appears to occur only after the animal achieves a critical weight. This suggests that activity levels are a consequence rather than a contributor to weight control. However, the existence of an inverse weight-activity relationship remains inconclusive. Confounding the results are the multi-factorial nature of physical activity and the lack of appropriate measuring devices. Furthermore, many determinants of body weight are closely interlocked making it difficult to determine whether a single, combination or interaction of factors is important for the regulation of activity. For example, diet-induced obesity, aging, lesions to tile ventral medial hypothalamus and genetics all produce hypoactivity. Providing a better understanding of the biological determinants involved in the regulation of activity has important implications for the development of strategies for the prevention of weight gain leading to obesity and subsequent morbidity and mortality in the human population.

  16. Determinants affecting physical activity levels in animal models

    NASA Technical Reports Server (NTRS)

    Tou, Janet C L.; Wade, Charles E.

    2002-01-01

    Weight control is dependent on energy balance. Reduced energy expenditure (EE) associated with decreased physical activity is suggested to be a major underlying cause in the increasing prevalence of weight gain and obesity. Therefore, a better understanding of the biological determinants involved in the regulation of physical activity is essential. To facilitate interpretation in humans, it is helpful to consider the evidence from animal studies. This review focuses on animal studies examining the biological determinants influencing activity and potential implications to human. It appears that physical activity is influenced by a number of parameters. However, regardless of the parameter involved, body weight appears to play an underlying role in the regulation of activity. Furthermore, the regulation of activity associated with body weight appears to occur only after the animal achieves a critical weight. This suggests that activity levels are a consequence rather than a contributor to weight control. However, the existence of an inverse weight-activity relationship remains inconclusive. Confounding the results are the multifactorial nature of physical activity and the lack of appropriate measuring devices. Furthermore, many determinants of body weight are closely interlocked, making it difficult to determine whether a single, combination, or interaction of factors is important for the regulation of activity. For example, diet-induced obesity, aging, lesions to the ventral medial hypothalamus, and genetics all produce hypoactivity. Providing a better understanding of the biological determinants involved in the regulation of activity has important implications for the development of strategies for the prevention of weight gain leading to obesity and subsequent morbidity and mortality in the human population.

  17. Plant Nitrogen Acquisition Under Low Availability: Regulation of Uptake and Root Architecture.

    PubMed

    Kiba, Takatoshi; Krapp, Anne

    2016-04-01

    Nitrogen availability is a major factor determining plant growth and productivity. Plants acquire nitrogen nutrients from the soil through their roots mostly in the form of ammonium and nitrate. Since these nutrients are scarce in natural soils, plants have evolved adaptive responses to cope with the environment. One of the most important responses is the regulation of nitrogen acquisition efficiency. This review provides an update on the molecular determinants of two major drivers of the nitrogen acquisition efficiency: (i) uptake activity (e.g. high-affinity nitrogen transporters) and (ii) root architecture (e.g. low-nitrogen-availability-specific regulators of primary and lateral root growth). Major emphasis is laid on the regulation of these determinants by nitrogen supply at the transcriptional and post-transcriptional levels, which enables plants to optimize nitrogen acquisition efficiency under low nitrogen availability. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists.

  18. Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC.

    PubMed

    Lightfoot, J Timothy; DE Geus, Eco J C; Booth, Frank W; Bray, Molly S; DEN Hoed, Marcel; Kaprio, Jaakko; Kelly, Scott A; Pomp, Daniel; Saul, Michael C; Thomis, Martine A; Garland, Theodore; Bouchard, Claude

    2018-04-01

    Physical activity unquestionably maintains and improves health; however, physical activity levels globally are low and not rising despite all the resources devoted to this goal. Attention in both the research literature and the public policy domain has focused on social-behavioral factors; however, a growing body of literature suggests that biological determinants play a significant role in regulating physical activity levels. For instance, physical activity level, measured in various manners, has a genetic component in both humans and nonhuman animal models. This consensus article, developed as a result of an American College of Sports Medicine-sponsored round table, provides a brief review of the theoretical concepts and existing literature that supports a significant role of genetic and other biological factors in the regulation of physical activity. Future research on physical activity regulation should incorporate genetics and other biological determinants of physical activity instead of a sole reliance on social and other environmental determinants.

  19. A New Component of the Nasonia Sex Determining Cascade Is Maternally Silenced and Regulates Transformer Expression

    PubMed Central

    Bopp, Daniel; Beukeboom, Leo W.; van de Zande, Louis

    2013-01-01

    Although sex determination is a universal process in sexually reproducing organisms, sex determination pathways are among the most highly variable genetic systems found in nature. Nevertheless, general principles can be identified among the diversity, like the central role of transformer (tra) in insects. When a functional TRA protein is produced in early embryogenesis, the female sex determining route is activated, while prevention of TRA production leads to male development. In dipterans, male development is achieved by prevention of female-specific splicing of tra mRNA, either mediated by X-chromosome dose or masculinizing factors. In Hymenoptera, which have haplodiploid sex determination, complementary sex determination and maternal imprinting have been identified to regulate timely TRA production. In the parasitoid Nasonia, zygotic transformer (Nvtra) expression and splicing is regulated by a combination of maternal provision of Nvtra mRNA and silencing of Nvtra expression in unfertilized eggs. It is unclear, however, if this silencing is directly on the tra locus or whether it is mediated through maternal silencing of a trans-acting factor. Here we show that in Nasonia, female sex determination is dependent on zygotic activation of Nvtra expression by an as yet unknown factor. This factor, which we propose to term womanizer (wom), is maternally silenced during oogenesis to ensure male development in unfertilized eggs. This finding implicates the upstream recruitment of a novel gene in the Nasonia sex determining cascade and supports the notion that sex determining cascades can rapidly change by adding new components on top of existing regulators. PMID:23717455

  20. 48 CFR 19.602 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedures. 19.602 Section 19.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility 19.602...

  1. Self-regulation and the problem of human autonomy: does psychology need choice, self-determination, and will?

    PubMed

    Ryan, Richard M; Deci, Edward L

    2006-12-01

    The term autonomy literally refers to regulation by the self. Its opposite, heteronomy, refers to controlled regulation, or regulation that occurs without self-endorsement. At a time when philosophers and economists are increasingly detailing the nature of autonomy and recognizing its social and practical significance, many psychologists are questioning the reality and import of autonomy and closely related phenomena such as will, choice, and freedom. Using the framework of self-determination theory (Ryan & Deci, 2000), we review research concerning the benefits of autonomous versus controlled regulation for goal performance, persistence, affective experience, quality of relationships, and well-being across domains and cultures. We also address some of the controversies and terminological issues surrounding the construct of autonomy, including critiques of autonomy by biological reductionists, cultural relativists, and behaviorists. We conclude that there is a universal and cross-developmental value to autonomous regulation when the construct is understood in an exacting way.

  2. 48 CFR 1516.303-74 - Determining the value of in-kind contributions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Determining the value of in-kind contributions. 1516.303-74 Section 1516.303-74 Federal Acquisition Regulations System... depreciation, if any) at the time of donation. If the booked costs reflect unrealistic values when compared to...

  3. 49 CFR 360.5 - Updating user fees.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... determined by the cost study in Regulations Governing Fees For Service, 1 I.C.C. 2d 60 (1984), or subsequent... material in the Federal Register or FMCSA Register. (This rounding procedures excludes copying, printing... determined by the cost study in Regulations Governing Fees For Service, 1 I.C.C. 2d 60 (1984), or subsequent...

  4. College Students' Motivation and Learning Strategies Profiles and Academic Achievement: A Self-Determination Theory Approach

    ERIC Educational Resources Information Center

    Liu, Woon Chia; Wang, Chee Keng John; Kee, Ying Hwa; Koh, Caroline; Lim, Boon San Coral; Chua, Lilian

    2014-01-01

    The development of effective self-regulated learning strategies is of interest to educationalists. In this paper, we examine inherent individual difference in self-regulated learning based on Motivated Learning for Learning Questionnaire (MLSQ) using the cluster analytic approach and examine cluster difference in terms of self-determination theory…

  5. Specificity of Relations between Adolescents' Cognitive Emotion Regulation Strategies and Internalizing and Externalizing Psychopathology

    ERIC Educational Resources Information Center

    Garnefski, Nadia; Kraaij, Vivian; van Etten, Marije

    2005-01-01

    Objective: of the study was to examine the extent to which cognitive emotion regulation strategies were "common determinants" of Internalizing and Externalizing problems and/or "specific determinants" distinguishing one problem category from the other. Method: The sample comprised 271 12- to 18-year-old secondary school students. Internalizing and…

  6. 76 FR 53819 - Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit AGENCY: Internal Revenue Service... purposes of the foreign tax credit. These regulations address certain highly structured arrangements that produce inappropriate foreign tax credit results. The regulations affect individuals and corporations that...

  7. 76 FR 53818 - Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit AGENCY: Internal Revenue Service... of taxes paid for purposes of the foreign tax credit. These regulations address certain highly structured arrangements that produce inappropriate foreign tax credit results. The regulations affect...

  8. 78 FR 54391 - Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit AGENCY: Internal Revenue Service... purposes of the foreign tax credit. These regulations address certain highly structured arrangements that produce inappropriate foreign tax credit results. The regulations affect individuals and corporations that...

  9. 76 FR 42076 - Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... Determining the Amount of Taxes Paid for Purposes of the Foreign Tax Credit AGENCY: Internal Revenue Service... purposes of the foreign tax credit. These regulations address certain highly structured arrangements that produce inappropriate foreign tax credit results. The text of those temporary regulations published in...

  10. 41 CFR 102-5.50 - May determinations be made in advance for employees who respond to unusual circumstances when...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May determinations be... 102-5.50 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 5-HOME-TO-WORK TRANSPORTATION Authorizing Home-to-Work...

  11. Quantitative method to determine the regional drinking water odorant regulation goals based on odor sensitivity distribution: illustrated using 2-MIB.

    PubMed

    Yu, Jianwei; An, Wei; Cao, Nan; Yang, Min; Gu, Junong; Zhang, Dong; Lu, Ning

    2014-07-01

    Taste and odor (T/O) in drinking water often cause consumer complaints and are thus regulated in many countries. However, people in different regions may exhibit different sensitivities toward T/O. This study proposed a method to determine the regional drinking water odorant regulation goals (ORGs) based on the odor sensitivity distribution of the local population. The distribution of odor sensitivity to 2-methylisoborneol (2-MIB) by the local population in Beijing, China was revealed by using a normal distribution function/model to describe the odor complaint response to a 2-MIB episode in 2005, and a 2-MIB concentration of 12.9 ng/L and FPA (flavor profile analysis) intensity of 2.5 was found to be the critical point to cause odor complaints. Thus the Beijing ORG for 2-MIB was determined to be 12.9 ng/L. Based on the assumption that the local FPA panel can represent the local population in terms of sensitivity to odor, and that the critical FPA intensity causing odor complaints was 2.5, this study tried to determine the ORGs for seven other cities of China by performing FPA tests using an FPA panel from the corresponding city. ORG values between 12.9 and 31.6 ng/L were determined, showing that a unified ORG may not be suitable for drinking water odor regulations. This study presents a novel approach for setting drinking water odor regulations. Copyright © 2014. Published by Elsevier B.V.

  12. 40 CFR 52.2275 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Control strategy and regulations: Ozone... strategy and regulations: Ozone. (a) Section 510.3 of revised Regulation V, which was submitted by the... Areas Did Not Attain the 1-Hour Ozone NAAQS. EPA has determined that the Houston/Galveston/Brazoria...

  13. 40 CFR 52.2275 - Control strategy and regulations: Ozone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Control strategy and regulations: Ozone... strategy and regulations: Ozone. (a) Section 510.3 of revised Regulation V, which was submitted by the... Areas Did Not Attain the 1-Hour Ozone NAAQS. EPA has determined that the Houston/Galveston/Brazoria...

  14. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What regulations apply to self-governance Tribes? 1000... INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to self-governance...

  15. 30 CFR 730.11 - Inconsistent and more stringent State laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations. 730.11 Section 730.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT... Register setting forth the text or a summary of any State law or regulation initially determined by him to... stringent land use and environmental controls and regulations of coal exploration and surface coal mining...

  16. 23 CFR 1.36 - Compliance with Federal laws and regulations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Compliance with Federal laws and regulations. 1.36... ADMINISTRATION GENERAL § 1.36 Compliance with Federal laws and regulations. If the Administrator determines that a State has violated or failed to comply with the Federal laws or the regulations in this part with...

  17. 23 CFR 1.36 - Compliance with Federal laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Compliance with Federal laws and regulations. 1.36... ADMINISTRATION GENERAL § 1.36 Compliance with Federal laws and regulations. If the Administrator determines that a State has violated or failed to comply with the Federal laws or the regulations in this part with...

  18. 23 CFR 1.36 - Compliance with Federal laws and regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Compliance with Federal laws and regulations. 1.36... ADMINISTRATION GENERAL § 1.36 Compliance with Federal laws and regulations. If the Administrator determines that a State has violated or failed to comply with the Federal laws or the regulations in this part with...

  19. 23 CFR 1.36 - Compliance with Federal laws and regulations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Compliance with Federal laws and regulations. 1.36... ADMINISTRATION GENERAL § 1.36 Compliance with Federal laws and regulations. If the Administrator determines that a State has violated or failed to comply with the Federal laws or the regulations in this part with...

  20. 23 CFR 1.36 - Compliance with Federal laws and regulations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Compliance with Federal laws and regulations. 1.36... ADMINISTRATION GENERAL § 1.36 Compliance with Federal laws and regulations. If the Administrator determines that a State has violated or failed to comply with the Federal laws or the regulations in this part with...

  1. Emotion regulation choice: the role of environmental affordances.

    PubMed

    Suri, Gaurav; Sheppes, Gal; Young, Gerald; Abraham, Damon; McRae, Kateri; Gross, James J

    2017-09-01

    Which emotion regulation strategy one uses in a given context can have profound affective, cognitive, and social consequences. It is therefore important to understand the determinants of emotion regulation choice. Many prior studies have examined person-specific, internal determinants of emotion regulation choice. Recently, it has become clear that external variables that are properties of the stimulus can also influence emotion regulation choice. In the present research, we consider whether reappraisal affordances, defined as the opportunities for re-interpretation of a stimulus that are inherent in that stimulus, can shape individuals' emotion regulation choices. We show that reappraisal affordances have stability across people and across time (Study 1), and are confounded with emotional intensity for a standardised set of picture stimuli (Study 2). Since emotional intensity has been shown to drive emotion regulation choice, we construct a context in which emotional intensity is separable from reappraisal affordances (Study 3) and use this context to show that reappraisal affordances powerfully influence emotion regulation choice even when emotional intensity and discrete emotions are taken into account (Study 4).

  2. Analysis of the dismounted motorist and road-worker model pedestrian safety regulations

    DOT National Transportation Integrated Search

    1982-08-01

    Two pedestrian model regulations previously developed by NHTSA were studied to determine their potential safety benefits. One regulation was concerned with the disabled-vehicle situation and called on motorists to position themselves and their vehicl...

  3. 48 CFR 30.602 - Materiality.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Materiality. 30.602 Section 30.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Administration 30.602 Materiality. (a) In determining...

  4. Gene regulation of plasmid- and chromosome-determined inorganic ion transport in bacteria.

    PubMed Central

    Silver, S; Walderhaug, M

    1992-01-01

    Regulation of chromosomally determined nutrient cation and anion uptake systems shows important similarities to regulation of plasmid-determined toxic ion resistance systems that mediate the outward transport of deleterious ions. Chromosomally determined transport systems result in accumulation of K+, Mg2+, Fe3+, Mn2+, PO4(3-), SO4(2-), and additional trace nutrients, while bacterial plasmids harbor highly specific resistance systems for AsO2-, AsO4(3-), CrO4(2-), Cd2+, Co2+, Cu2+, Hg2+, Ni2+, SbO2-, TeO3(2-), Zn2+, and other toxic ions. To study the regulation of these systems, we need to define both the trans-acting regulatory proteins and the cis-acting target operator DNA regions for the proteins. The regulation of gene expression for K+ and PO4(3-) transport systems involves two-component sensor-effector pairs of proteins. The first protein responds to an extracellular ionic (or related) signal and then transmits the signal to an intracellular DNA-binding protein. Regulation of Fe3+ transport utilizes the single iron-binding and DNA-binding protein Fur. The MerR regulatory protein for mercury resistance both represses and activates transcription. The ArsR regulatory protein functions as a repressor for the arsenic and antimony(III) efflux system. Although the predicted cadR regulatory gene has not been identified, cadmium, lead, bismuth, zinc, and cobalt induce this system in a carefully regulated manner from a single mRNA start site. The cadA Cd2+ resistance determinant encodes an E1(1)-1E2-class efflux ATPase (consisting of two polypeptides, rather than the one earlier identified). Cadmium resistance is also conferred by the czc system (which confers resistances to zinc and cobalt in Alcaligenes species) via a complex efflux pump consisting of four polypeptides. These two cadmium efflux systems are not otherwise related. For chromate resistance, reduced cellular accumulation is again the resistance mechanism, but the regulatory components are not identified. For other toxic heavy metals (with few exceptions), there exist specific plasmid resistances that remain relatively terra incognita for future exploration of bioinorganic molecular genetics and gene regulation. PMID:1579110

  5. New GMO regulations for old: Determining a new future for EU crop biotechnology.

    PubMed

    Davison, John; Ammann, Klaus

    2017-01-02

    In this review, current EU GMO regulations are subjected to a point-by point analysis to determine their suitability for agriculture in modern Europe. Our analysis concerns present GMO regulations as well as suggestions for possible new regulations for genome editing and New Breeding Techniques (for which no regulations presently exist). Firstly, the present GMO regulations stem from the early days of recombinant DNA and are not adapted to current scientific understanding on this subject. Scientific understanding of GMOs has changed and these regulations are now, not only unfit for their original purpose, but, the purpose itself is now no longer scientifically valid. Indeed, they defy scientific, economic, and even common, sense. A major EU regulatory preconception is that GM crops are basically different from their parent crops. Thus, the EU regulations are "process based" regulations that discriminate against GMOs simply because they are GMOs. However current scientific evidence shows a blending of classical crops and their GMO counterparts with no clear demarcation line between them. Canada has a "product based" approach and determines the safety of each new crop variety independently of the process used to obtain it. We advise that the EC re-writes it outdated regulations and moves toward such a product based approach.  Secondly, over the last few years new genomic editing techniques (sometimes called New Breeding Techniques) have evolved. These techniques are basically mutagenesis techniques that can generate genomic diversity and have vast potential for crop improvement. They are not GMO based techniques (any more than mutagenesis is a GMO technique), since in many cases no new DNA is introduced. Thus they cannot simply be lumped together with GMOs (as many anti-GMO NGOs would prefer). The EU currently has no regulations to cover these new techniques. In this review, we make suggestions as to how these new gene edited crops may be regulated. The EU is at a turning point where the wrong decision could destroy European agricultural competitively for decades to come.

  6. Motivational Profiles in Physical Education and Their Relation to the Theory of Planned Behavior

    PubMed Central

    Moreno-Murcia, Juan Antonio; Cervelló Gimeno, Eduardo; Hernández, Elisa Huéscar; Pedreño, Noelia Belan-do; Rodríguez Marín, Jesús Jesus

    2013-01-01

    The aim of this study was to establish motivational profiles for doing physical activity according to the variables from the theory of planned action in a sample of 698 students aged 14 to 16. The instruments used were the Questionnaire of Behavioral Regulation in Sport (BRQ-R) and the Questionnaire of the Theory of Planned Behavior (TCP). Cluster analysis revealed two motivational profiles: a “self-determined ”profile with high scores in intrinsic motivation and low scores in extrinsic motivation and amotivation, and a “non self- determined ”profile with low scores in intrinsic motivation and high scores in extrinsic motivation and amotivation. Positive significant differences in attitudes, norms, and intent to control were found for the self-determined profile related to “non self-determined ”profile. Key Points A “self-determined ”profile was found with higher scores for the four types of intrinsic motivations (general, knowledge, stimulation and achievement) and identified regulation than for introjected and external regulation. A “non self-determined ”profile was found with higher scores for external, introjected regulation and amotivation than for the four types of intrinsic motivation (general, knowledge, stimulation and achievement). In the context of the “non self-determined profile ”we could encourage programs that adapt to these needs in such a way that they contribute to increasing the rates of doing physical activity in the population. PMID:24149164

  7. The antecedents and consequences of autonomous self-regulation for college: a self-determination theory perspective on socialization.

    PubMed

    Niemiec, Christopher P; Lynch, Martin F; Vansteenkiste, Maarten; Bernstein, Jessey; Deci, Edward L; Ryan, Richard M

    2006-10-01

    Using self-determination theory, two studies investigated the relations among perceived need support from parents, their adolescents' autonomous self-regulation for academics, and the adolescents' well-being. Study 1 indicated that perceived need support from parents independently predicted adolescents' well-being, although when mothers' and fathers' data were examined separately, the relation was stronger for mothers than for fathers. In Study 2, autonomous self-regulation for planning to attend college was a significant partial mediator of the relation of adolescents' perceived need support to well-being. Thus, perceived need support from parents does seem important for the development of adolescents' autonomous self-regulation and well-being.

  8. [Inconsistencies between building regulations in force in Italy for indoor environment and wellness factors].

    PubMed

    Faggioli, A; Capasso, L

    2015-01-01

    Indoor environment is one of major health determinants, and the regulations that set the sanitary requirements are of primary importance for the protection of public health. The authors analyse the critical aspects of the complex Italian regulatory system, starting from the EU regulations, through national and regional laws, and finally the municipal regulations. They underline the need for more uniformity and clarity in the determination of health standards, as well as for a simplification of the existing legislation. Moreover, they highlight the importance of controlling and monitoring indoor environment, currently almost completely absent in Italy due to the effects of the regulatory changes of the latest years.

  9. 48 CFR 701.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2016-10-01

    ... 48 Federal Acquisition Regulations System 5 2016-10-01 2016-10-01 false Content. 701.704 Section 701.704 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Determinations and Findings 701.704 Content. There is no USAID-prescribed format...

  10. 48 CFR 701.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Content. 701.704 Section 701.704 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Determinations and Findings 701.704 Content. There is no USAID-prescribed format...

  11. 48 CFR 701.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Content. 701.704 Section 701.704 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Determinations and Findings 701.704 Content. There is no USAID-prescribed format...

  12. 49 CFR 355.21 - Regulatory review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... shall determine: (i) The safety benefits associated with such State law or regulation; and (ii) The... has the same effect as a corresponding section of the Federal Motor Carrier Safety Regulations; (ii... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY...

  13. Regulatory Exclusions and Alternative Standards for the Recycling of Materials, Solid Wastes and Hazardous Wastes

    EPA Pesticide Factsheets

    Determining the Level of Regulation for Hazardous Waste Recycling, Recycled Materials that are not Subject to RCRA Hazardous Waste Regulation, Materials Subject to Alternative Regulatory Controls, Materials Subject to Full Hazardous Waste Regulations.

  14. 48 CFR 19.301 - Representations and rerepresentations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Representations and rerepresentations. 19.301 Section 19.301 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Determination of Small Business Status for Small Business...

  15. Why do women engage in fat talk? Examining fat talk using Self-Determination Theory as an explanatory framework.

    PubMed

    Guertin, Camille; Barbeau, Kheana; Pelletier, Luc; Martinelli, Gabrielle

    2017-03-01

    This study used Self-Determination Theory to examine the motivational processes involved in individuals' engagement in fat talk and its association with unhealthy eating behaviors. Female undergraduate students (N=453) completed an online questionnaire, which assessed general and contextual motivation, importance placed on goals, fat talk, and unhealthy eating behaviors. Structural equation modeling revealed that being generally non-self-determined and placing more importance on extrinsic goals, such as thinness, was associated with fat talk. Fat talk was further associated with non-self-determined motivation for eating regulation, which in turn was associated with unhealthy eating. General self-determination and placing more importance on intrinsic goals, such as health, were not associated with fat talk, but instead, were associated with more adaptive forms of eating regulation and diet quality. Findings further current knowledge on the respective roles of motivation and goals on the engagement in fat talk, and its consequences on eating regulation and behavior. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Intrinsic Versus Extrinsic Goal Contents in Self-Determination Theory: Another Look at the Quality of Academic Motivation

    ERIC Educational Resources Information Center

    Vansteenkiste, Maarten; Lens, Willy; Deci, Edward L.

    2006-01-01

    Examination of motivational dynamics in academic contexts within self-determination theory has centered primarily around both the motives (initially intrinsic vs. extrinsic, later autonomous vs. controlled) that regulate learners' study behavior and the contexts that promote or hinder these regulations. Less attention has been paid to the goal…

  17. Formation and modification of farm crops resistance in agrocoenoses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ulyanenko, L.N.; Filipas, A.S.

    1993-12-31

    Experiments were conducted to determine the effects of chronic exposure to low doses of ionizing radiation to barley plants. The possible use of growth regulators for decreasing accumulation of major radionuclides was investigated. It was determined that treating the seeds with growth regulators before sowing decreased the radiocesium content in barley two to three fold.

  18. 26 CFR 1.851-4 - Determination of status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) INCOME TAXES Regulated Investment Companies and Real Estate Investment Trusts § 1.851-4 Determination of... investments and the requirements of section 851(b)(4) and paragraph (c) of § 1.851-2, or the effect that the elimination of such discrepancies will have on the status of a company as a regulated investment company for...

  19. Determinants of Non-Compliance of Public Procurement Regulations in Kenyan Secondary Schools

    ERIC Educational Resources Information Center

    Migosi, Joash; Ombuki, Charles; Ombuki, Kennedy N.; Evusa, Zablon

    2013-01-01

    Kenya's public procurement and disposal Act of 2005 sets out clear rules and procedures for public procurement entities to follow; however this does not seem to be the case. This study sought to examine determinants of Non-compliance to the Public Procurement Regulations in Kenyan Secondary Schools. The study adopted a descriptive survey research.…

  20. Criteria for a catastrophically disabled determination for purposes of enrollment. Final rule.

    PubMed

    2013-12-03

    The Department of Veterans Affairs (VA) is amending its regulation concerning the manner in which VA determines that a veteran is catastrophically disabled for purposes of enrollment in priority group 4 for VA health care. As amended by this rulemaking, the regulation articulates the clinical criteria that identify an individual as catastrophically disabled, instead of using the corresponding International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and Current Procedural Terminology (CPT[registered trademark]) codes. The revisions ensure that the regulation is not out of date when new versions of those codes are published. The revisions also broaden some of the descriptions for a finding of catastrophic disability. Additionally, the final rule does not rely on the Folstein Mini Mental State Examination (MMSE) as a criterion for determining whether a veteran meets the definition of catastrophically disabled, because we have determined that the MMSE is no longer a necessary clinical assessment tool.

  1. Sex Determination in Ceratopteris richardii Is Accompanied by Transcriptome Changes That Drive Epigenetic Reprogramming of the Young Gametophyte.

    PubMed

    Atallah, Nadia M; Vitek, Olga; Gaiti, Federico; Tanurdzic, Milos; Banks, Jo Ann

    2018-05-02

    The fern Ceratopteris richardii is an important model for studies of sex determination and gamete differentiation in homosporous plants. Here we use RNA-seq to de novo assemble a transcriptome and identify genes differentially expressed in young gametophytes as their sex is determined by the presence or absence of the male-inducing pheromone called antheridiogen. Of the 1,163 consensus differentially expressed genes identified, the vast majority (1,030) are up-regulated in gametophytes treated with antheridiogen. GO term enrichment analyses of these DEGs reveals that a large number of genes involved in epigenetic reprogramming of the gametophyte genome are up-regulated by the pheromone. Additional hormone response and development genes are also up-regulated by the pheromone. This C. richardii gametophyte transcriptome and gene expression dataset will prove useful for studies focusing on sex determination and differentiation in plants. Copyright © 2018, G3: Genes, Genomes, Genetics.

  2. 78 FR 27856 - Golden Nematode; Removal of Regulated Areas in Livingston and Steuben Counties, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    .... APHIS-2012-0079] Golden Nematode; Removal of Regulated Areas in Livingston and Steuben Counties, NY... nematode regulations by removing areas in Livingston and Steuben Counties in New York from the list of... nematode, and we determined that regulation of these areas was no longer necessary. As a result of that...

  3. 48 CFR 25.702-3 - Remedies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Remedies. 25.702-3 Section 25.702-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Prohibited Sources 25.702-3 Remedies. Upon the determination of a false certification...

  4. 48 CFR 25.702-3 - Remedies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Remedies. 25.702-3 Section 25.702-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Prohibited Sources 25.702-3 Remedies. Upon the determination of a false certification...

  5. 48 CFR 225.104 - Nonavailable articles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Nonavailable articles. 225.104 Section 225.104 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Nonavailable articles. (a) DoD has determined that the following articles also are nonavailable in accordance...

  6. 48 CFR 225.104 - Nonavailable articles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Nonavailable articles. 225.104 Section 225.104 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Nonavailable articles. (a) DoD has determined that the following articles also are nonavailable in accordance...

  7. 48 CFR 19.602-4 - Awarding the contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Awarding the contract. 19.602-4 Section 19.602-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility...

  8. 48 CFR 225.7003-3 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Exceptions. 225.7003-3 Section 225.7003-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... the recommendation of the Strategic Materials Protection Board pursuant to 10 U.S.C. 187, determines...

  9. Effect of a behavioral intervention on dimensions of self-regulation and physical activity among overweight and obese adults with type 2 diabetes: a pilot study.

    PubMed

    Silfee, Valerie; Petosa, Rick; Laurent, Devin; Schaub, Timothy; Focht, Brian

    2016-09-01

    The purpose of this pilot study was to determine the preliminary effect of a behavioral intervention on the use of self-regulation strategies and moderate-to-vigorous physical activity (MVPA) in overweight and obese adults with type 2 diabetes. 23 individuals recruited from ResearchMatc.org and campus advertisements were randomized into an intervention (n = 12) and control (n = 11) group. The intervention group received a behavioral intervention that used goal setting, time management, and self-monitoring to target dimensions of self-regulation and MVPA. The control received information regarding their PA habits. MVPA was measured via BodyMedia Armbands at pre- and post-test. The use of self-regulatory strategies for MVPA was assessed at pretest and posttest using the Self-Regulation for Exercise Scale. Cohen's d effect sizes were calculated to determine the practical impact of the intervention. The intervention had a large effect on all dimensions of self-regulation across time: including total self-regulation (3.15), self-monitoring (4.63), goal setting (3.17), social support (1.29), self-reward (1.98), time management (4.41), and overcoming barriers (2.25). The intervention had no impact on dimensions of MVPA across time. This pilot study demonstrated the ability of a behavioral intervention to improve the use of self-regulation strategies for MVPA in a sample of adults with type 2 diabetes. These findings can further inform the development of health promotion programs to promote self-regulation. Future research should focus on determining ability of improvements in self-regulation to stimulate behavior change.

  10. New potential markers of in vitro tomato morphogenesis identified by mRNA differential display.

    PubMed

    Torelli, A; Soragni, E; Bolchi, A; Petrucco, S; Ottonello, S; Branca, C

    1996-12-01

    The identification of plant genes involved in early phases of in vitro morphogenesis can not only contribute to our understanding of the processes underlying growth regulator-controlled determination, but also provide novel markers for evaluating the outcome of in vitro regeneration experiments. To search for such genes and to monitor changes in gene expression accompanying in vitro regeneration, we have adapted the mRNA differential display technique to the comparative analysis of a model system of tomato cotyledons that can be driven selectively toward either shoot or callus formation by means of previously determined growth regulator supplementations. Hormone-independent transcriptional modulation (mainly down-regulation) has been found to be the most common event, indicating that a non-specific reprogramming of gene expression quantitatively predominates during the early phases of in vitro culture. However, cDNA fragments representative of genes that are either down-regulated or induced in a programme-specific manner could also be identified, and two of them (G35, G36) were further characterized. One of these cDNA fragments, G35, corresponds to an mRNA that is down-regulated much earlier in callus- (day 2) than in shoot-determined explants (day 6). The other, G36, identifies an mRNA that is transiently expressed in shoot-determined explants only, well before any macroscopic signs of differentiation become apparent, and thus exhibits typical features of a morphogenetic marker.

  11. 48 CFR 3.906 - Remedies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Remedies. 3.906 Section 3.906 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS... Remedies. (a) If the head of the agency or designee determines that a contractor has subjected one of its...

  12. 48 CFR 3.906 - Remedies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Remedies. 3.906 Section 3.906 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL IMPROPER BUSINESS... Remedies. (a) If the head of the agency or designee determines that a contractor has subjected one of its...

  13. Agriculture: Laws and Regulations that Apply to Your Agricultural Operation by Farm Activity

    EPA Pesticide Factsheets

    A general description of EPA’s requirements applicable to agriculture, and should only be used as a guide. Since rules and regulations may change use this information is a starting place to determine which regulations apply to your agricultural operation.

  14. 76 FR 11395 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... identify specific current regulations that may be outdated, ineffective, or excessively burdensome. The purpose of this regulatory review is to make the Department's regulations more effective and less... review existing significant regulations to determine if they are outmoded, ineffective, insufficient or...

  15. 48 CFR 16.301-3 - Limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-reimbursement contract may be used only when— (1) The contractor's accounting system is adequate for determining... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Limitations. 16.301-3 Section 16.301-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS...

  16. 48 CFR 206.302-7 - Public interest.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Public interest. 206.302-7 Section 206.302-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM....302-7 Public interest. (c) Limitations. For the defense agencies, the written determination to use...

  17. 48 CFR 206.302-7 - Public interest.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Public interest. 206.302-7 Section 206.302-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM....302-7 Public interest. (c) Limitations. For the defense agencies, the written determination to use...

  18. 48 CFR 206.302-7 - Public interest.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Public interest. 206.302-7 Section 206.302-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM....302-7 Public interest. (c) Limitations. For the defense agencies, the written determination to use...

  19. 48 CFR 206.302-7 - Public interest.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Public interest. 206.302-7 Section 206.302-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM....302-7 Public interest. (c) Limitations. For the defense agencies, the written determination to use...

  20. Insect sex determination: it all evolves around transformer.

    PubMed

    Verhulst, Eveline C; van de Zande, Louis; Beukeboom, Leo W

    2010-08-01

    Insects exhibit a variety of sex determining mechanisms including male or female heterogamety and haplodiploidy. The primary signal that starts sex determination is processed by a cascade of genes ending with the conserved switch doublesex that controls sexual differentiation. Transformer is the doublesex splicing regulator and has been found in all examined insects, indicating its ancestral function as a sex-determining gene. Despite this conserved function, the variation in transformer nucleotide sequence, amino acid composition and protein structure can accommodate a multitude of upstream sex determining signals. Transformer regulation of doublesex and its taxonomic distribution indicate that the doublesex-transformer axis is conserved among all insects and that transformer is the key gene around which variation in sex determining mechanisms has evolved.

  1. [The relationship between autonomous motivation and academic adjustment in junior high school students].

    PubMed

    Nishimura, Takuma; Sakurai, Shigeo

    2013-10-01

    This study investigated the relationship between autonomous motivation and academic adjustment based on the perspective of self-determination theory. It also examined motivational profiles to reveal individual differences and the characteristic of these profiles for groups with varying levels of autonomous and controlled regulation (autonomous, controlled, high motivation, and low motivation). Data were collected from 442 junior high school students for academic motivation, academic performance, academic competence, meta-cognitive strategy, academic anxiety, apathy, and stress experience. Correlation analyses generally supported the basic hypothesis of self-determination theory that a more autonomous regulation style was strongly related to academic adjustment. The results also showed that persons with a high autonomous regulation and a low controlled regulation style were the most adaptive.

  2. Method of Testing Oxygen Regulators

    NASA Technical Reports Server (NTRS)

    Sontag, Harcourt; Borlik, E L

    1935-01-01

    Oxygen regulators are used in aircraft to regulate automatically the flow of oxygen to the pilot from a cylinder at pressures ranging up to 150 atmospheres. The instruments are adjusted to open at an altitude of about 15,000 ft. and thereafter to deliver oxygen at a rate which increases with the altitude. The instruments are tested to determine the rate of flow of oxygen delivered at various altitudes and to detect any mechanical defects which may exist. A method of testing oxygen regulators was desired in which the rate of flow could be determined more accurately than by the test method previously used (reference 1) and by which instruments defective mechanically could be detected. The new method of test fulfills these requirements.

  3. 40 CFR 63.4361 - How do I determine the emission capture system efficiency?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Method 204A or 204F of appendix M to 40 CFR part 51 to determine the mass fraction of TVH liquid input... the capture efficiency test run, kg. TVHi = Mass fraction of TVH in regulated material, i, that is... protocol compares the mass of liquid TVH in regulated materials applied in the web coating/printing or...

  4. 40 CFR 63.4361 - How do I determine the emission capture system efficiency?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Method 204A or 204F of appendix M to 40 CFR part 51 to determine the mass fraction of TVH liquid input... the capture efficiency test run, kg. TVHi = Mass fraction of TVH in regulated material, i, that is... protocol compares the mass of liquid TVH in regulated materials applied in the web coating/printing or...

  5. Impact of Self-Regulation Skills on Academic Performance of Young Children in Private Schools of Karachi

    ERIC Educational Resources Information Center

    Kathawala, Abeer; Bhamani, Shelina

    2015-01-01

    This research aimed to explore if self-regulation skills had any effect on the academic outcomes of young children in private schools of Karachi, Pakistan. Quantitative research method was used to determine the impact of self-regulation upon the academic outcome of young children by utilizing Early School Self-Regulation Scale-Care Giver Version…

  6. Exploring Suitable Emotion-Focused Strategies in Helping Students to Regulate Their Emotional State in a Tutoring System: Malaysian Case Study

    ERIC Educational Resources Information Center

    Yusoff, Mohd Zaliman Mohd; Zin, Nor Azan Mat

    2013-01-01

    Introduction: This study explored the suitable emotion-focused strategies in helping students to regulate their emotional state in a self-regulated tutoring system. Method: A questionnaire which consists of 25 different regulation strategies adapted from Way of Coping Questionnaire (WCQ) was used to determine the strategies deployed by the…

  7. Boys Might Catch Up, Family Influences Continue: Influences on Behavioral Self-Regulation in Children from an Affluent Region in Germany before School Entry

    ERIC Educational Resources Information Center

    Gunzenhauser, Catherine; von Suchodoletz, Antje

    2015-01-01

    Research Findings: Behavioral self-regulation is crucial for school success. Although behavioral self-regulation typically grows rapidly during the preschool period, children in this age group vary widely in their behavioral self-regulation capacities. The present study investigated 3 potential determinants of growth rates in behavioral…

  8. Thermal Regulation of Heat Transfer Processes

    DTIC Science & Technology

    2014-10-02

    determine the contrasts of thermophysical properties of composites and thin films , and various approaches to regulate heat transport processes. In the...nanofluids, 2) thermal regulation of optical properties in thin film , and 3) thermal regulation of phase transition for efficient steam generation...stress generated during the crystals growth forces CNTs to contact with each other and form a conductive percolation network. Hence the composite

  9. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

    PubMed Central

    Tykocki, Nathan R.; Boerman, Erika M.; Jackson, William F.

    2017-01-01

    Vascular tone of resistance arteries and arterioles determines peripheral vascular resistance, contributing to the regulation of blood pressure and blood flow to, and within the body’s tissues and organs. Ion channels in the plasma membrane and endoplasmic reticulum of vascular smooth muscle cells (SMCs) in these blood vessels importantly contribute to the regulation of intracellular Ca2+ concentration, the primary determinant of SMC contractile activity and vascular tone. Ion channels provide the main source of activator Ca2+ that determines vascular tone, and strongly contribute to setting and regulating membrane potential, which, in turn, regulates the open-state-probability of voltage gated Ca2+ channels (VGCCs), the primary source of Ca2+ in resistance artery and arteriolar SMCs. Ion channel function is also modulated by vasoconstrictors and vasodilators, contributing to all aspects of the regulation of vascular tone. This review will focus on the physiology of VGCCs, voltage-gated K+ (KV) channels, large-conductance Ca2+-activated K+ (BKCa) channels, strong-inward-rectifier K+ (KIR) channels, ATP-sensitive K+ (KATP) channels, ryanodine receptors (RyRs), inositol 1,4,5-trisphosphate receptors (IP3Rs), and a variety of transient receptor potential (TRP) channels that contribute to pressure-induced myogenic tone in resistance arteries and arterioles, the modulation of the function of these ion channels by vasoconstrictors and vasodilators, their role in the functional regulation of tissue blood flow and their dysfunction in diseases such as hypertension, obesity, and diabetes. PMID:28333380

  10. Behavioral regulations and dispositional flow in exercise among American college students relative to stages of change and gender.

    PubMed

    Ersöz, Gözde; Eklund, Robert C

    2017-01-01

    The purpose of this study was to examine behavioral regulations and dispositional flow in exercise among university students in terms of gender and stage of change. Data were collected from American college students (N = 257; M age ± SD = 23.02 ± 4.05) in Spring 2013. Behavioral regulations and dispositional flow in exercise were assessed, along with stage of change. Exercisers in the maintenance stage of change displayed significantly more self-determined motivation to exercise and a greater tendency to experience flow than those in preparation and action stages. Significant correlations were observed among behavioral regulations and flow state. Nonsignificant differences were observed for gender on behavioral regulations and dispositional flow in exercise. The results suggest that promotion of self-determined motivation and dispositional flow in exercisers may improve the quality of their experiences, as well as to foster their exercise behavior.

  11. Ethylene responsive factor ERF110 mediates ethylene-regulated transcription of a sex determination-related orthologous gene in two Cucumis species.

    PubMed

    Tao, Qianyi; Niu, Huanhuan; Wang, Zhongyuan; Zhang, Wenhui; Wang, Hu; Wang, Shenhao; Zhang, Xian; Li, Zheng

    2018-05-25

    In plants, unisexual flowers derived from developmental sex determination form separate stamens and pistils that facilitate cross pollination. In cucumber and melon, ethylene plays a key role in sex determination. Six sex determination-related genes have been identified in ethylene biosynthesis in these Cucumis species. The interactions among these genes are thought to involve ethylene signaling; however, the underlying mechanism of regulation remains unknown. In this study, hormone treatment and qPCR assays were used to confirm expression of these sex determination-related genes in cucumber and melon is ethylene sensitive. RNA-Seq analysis subsequently helped identify the ethylene responsive factor (ERF) gene, CsERF110, related to ethylene signaling and sex determination. CsERF110 and its melon ortholog, CmERF110, shared a conserved AP2/ERF domain and showed ethylene-sensitive expression. Yeast one-hybrid and ChIP-PCR assays further indicated that CsERF110 bound to at least two sites in the promoter fragment of CsACS11, while transient transformation analysis showed that CsERF110 and CmERF110 enhance CsACS11 and CmACS11 promoter activity, respectively. Taken together, these findings suggest that CsERF110 and CmERF110 respond to ethylene signaling, mediating ethylene-regulated transcription of CsACS11 and CmACS11 in cucumber and melon, respectively. Furthermore, the mechanism involved in its regulation is thought to be conserved in these two Cucumis species.

  12. Higher Education Regulations Study: Preliminary Findings

    ERIC Educational Resources Information Center

    Advisory Committee on Student Financial Assistance, 2011

    2011-01-01

    In the "Higher Education Opportunity Act" of 2008, Congress charged the Advisory Committee on Student Financial Assistance with conducting a review and analysis of regulations affecting higher education, to determine the extent to which regulations are overly burdensome and need to be streamlined, improved, or eliminated. Specifically,…

  13. 48 CFR 301.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2000-10-01

    ... 48 Federal Acquisition Regulations System 4 2000-10-01 2000-10-01 false Content. 301.704 Section 301.704 Federal Acquisition Regulations System DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Determinations and Findings 301.704 Content. An example of a D&F format may be...

  14. 7 CFR 2903.1 - Applicability of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.1 Applicability of regulations. (a) The regulations of this part only apply to Biodiesel Fuel Education Program grants awarded... determined by the Secretary), and the public about the benefits of biodiesel fuel use. Eligibility is limited...

  15. 7 CFR 2903.1 - Applicability of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.1 Applicability of regulations. (a) The regulations of this part only apply to Biodiesel Fuel Education Program grants awarded... determined by the Secretary), and the public about the benefits of biodiesel fuel use. Eligibility is limited...

  16. 7 CFR 2903.1 - Applicability of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.1 Applicability of regulations. (a) The regulations of this part only apply to Biodiesel Fuel Education Program grants awarded... determined by the Secretary), and the public about the benefits of biodiesel fuel use. Eligibility is limited...

  17. 7 CFR 2903.1 - Applicability of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.1 Applicability of regulations. (a) The regulations of this part only apply to Biodiesel Fuel Education Program grants awarded... determined by the Secretary), and the public about the benefits of biodiesel fuel use. Eligibility is limited...

  18. 7 CFR 2903.1 - Applicability of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.1 Applicability of regulations. (a) The regulations of this part only apply to Biodiesel Fuel Education Program grants awarded... determined by the Secretary), and the public about the benefits of biodiesel fuel use. Eligibility is limited...

  19. 76 FR 1101 - Property Traded on an Established Market

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... Property Traded on an Established Market AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice... regulations relating to determining when property is traded on an established market (that is, publicly traded... regulations to clarify the circumstances that cause property to be publicly traded. The regulations provide...

  20. 75 FR 43205 - Enforcement Proceeding: In the Matter of: Certain Voltage Regulators, Components Thereof and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... INTERNATIONAL TRADE COMMISSION [Inv. No. 337-TA-564] Enforcement Proceeding: In the Matter of: Certain Voltage Regulators, Components Thereof and Products Containing Same; Notice of Final Determination... the United States after importation of certain voltage regulators, components thereof and products...

  1. 48 CFR 52.247-60 - Guaranteed Shipping Characteristics.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Guaranteed Shipping Characteristics. 52.247-60 Section 52.247-60 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... information will be used to determine transportation costs for evaluation purposes. If the offeror does not...

  2. 48 CFR 52.247-60 - Guaranteed Shipping Characteristics.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Guaranteed Shipping Characteristics. 52.247-60 Section 52.247-60 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... information will be used to determine transportation costs for evaluation purposes. If the offeror does not...

  3. 76 FR 9076 - Proposed Collection; Comment Request for Regulation Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... soliciting comments concerning an existing final regulation, REG-120168-97 (TD 8798), Preparer Due Diligence...: Preparer Due Diligence Requirements for Determining Earned Income Credit Eligibility. OMB Number: 1545-1570... due diligence requirements in this regulation will avoid the imposition of the penalty section 6695(g...

  4. Higher Education Regulations Study: Final Report

    ERIC Educational Resources Information Center

    Advisory Committee on Student Financial Assistance, 2011

    2011-01-01

    In the "Higher Education Opportunity Act" of 2008, Congress charged the Advisory Committee on Student Financial Assistance with conducting a review and analysis of regulations affecting higher education to determine the extent to which regulations are overly burdensome and need to be streamlined, improved, or eliminated. Specifically, Congress…

  5. 48 CFR 52.232-13 - Notice of Progress Payments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... be inoperative during any time the contractor's accounting system and controls are determined by the... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Notice of Progress Payments. 52.232-13 Section 52.232-13 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION...

  6. A Review of State Licensing Regulations to Determine Alignment with Best Practices to Prevent Human Norovirus Infections in Child-Care Centers

    PubMed Central

    Leone, Cortney M.; Jaykus, Lee-Ann; Cates, Sheryl M.

    2016-01-01

    Objectives Close, frequent contact between children and care providers in child-care centers presents many opportunities to spread human noroviruses. We compared state licensing regulations for child-care centers with national guidelines written to prevent human noroviruses. Methods We reviewed child-care licensing regulations for all 50 U.S. states and the District of Columbia in effect in June 2015 to determine if these regulations fully, partially, or did not address 14 prevention practices in four topic areas: (1) hand hygiene, (2) exclusion of ill people, (3) environmental sanitation, and (4) diapering. Results Approximately two-thirds (8.9) of the 14 practices across all state regulations were partially or fully addressed, with few (2.6) fully addressed. Practices related to exclusion of ill people and diapering were fully addressed most often, while practices related to hand hygiene and environmental sanitation were fully addressed least often. Conclusion Regulations based on guidelines for best practices are one way to prevent the spread of human noroviruses in child-care facilities, if the regulations are enforced. Our findings show that, in mid-2015, many state child-care regulations did not fully address these guidelines, suggesting the need to review these regulations to be sure they are based on best practices PMID:27252565

  7. A Review of State Licensing Regulations to Determine Alignment with Best Practices to Prevent Human Norovirus Infections in Child-Care Centers.

    PubMed

    Leone, Cortney M; Jaykus, Lee-Ann; Cates, Sheryl M; Fraser, Angela M

    2016-01-01

    Close, frequent contact between children and care providers in child-care centers presents many opportunities to spread human noroviruses. We compared state licensing regulations for child-care centers with national guidelines written to prevent human noroviruses. We reviewed child-care licensing regulations for all 50 U.S. states and the District of Columbia in effect in June 2015 to determine if these regulations fully, partially, or did not address 14 prevention practices in four topic areas: (1) hand hygiene, (2) exclusion of ill people, (3) environmental sanitation, and (4) diapering. Approximately two-thirds (8.9) of the 14 practices across all state regulations were partially or fully addressed, with few (2.6) fully addressed. Practices related to exclusion of ill people and diapering were fully addressed most often, while practices related to hand hygiene and environmental sanitation were fully addressed least often. Regulations based on guidelines for best practices are one way to prevent the spread of human noroviruses in child-care facilities, if the regulations are enforced. Our findings show that, in mid-2015, many state child-care regulations did not fully address these guidelines, suggesting the need to review these regulations to be sure they are based on best practices.

  8. BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.

    PubMed

    Sehgal, Rachna; Sheibani, Nader; Rhodes, Simon J; Belecky Adams, Teri L

    2009-08-15

    Pax2 is essential for development of the neural tube, urogenital system, optic vesicle, optic cup and optic tract. In the eye, Pax2 deficiency is associated with coloboma, a loss of astrocytes in the optic nerve and retina, and abnormal axonal pathfinding of the ganglion cell axons at the optic chiasm. Thus, appropriate expression of Pax2 is essential for astrocyte determination and differentiation. Although BMP7 and SHH have been shown to regulate Pax2 expression, the molecular mechanism by which this regulation occurs is not well understood. In this study, we determined that BMP7 and SHH activate Pax2 expression in mouse retinal astrocyte precursors in vitro. SHH appeared to play a dual role in Pax2 regulation; 1) SHH may regulate BMP7 expression, and 2) the SHH pathway cooperates with the BMP pathway to regulate Pax2 expression. BMP and SHH pathway members can interact separately or together with TLX, a repressor protein in the tailless transcription factor family. Here we show that the interaction of both pathways with TLX relieves the repression of Pax2 expression in mouse retinal astrocytes. Together these data reveal a new mechanism for the cooperative actions of signaling pathways in astrocyte determination and differentiation and suggest interactions of regulatory pathways that are applicable to other developmental programs.

  9. Self-Organization of Blood Pressure Regulation: Experimental Evidence

    PubMed Central

    Fortrat, Jacques-Olivier; Levrard, Thibaud; Courcinous, Sandrine; Victor, Jacques

    2016-01-01

    Blood pressure regulation is a prime example of homeostatic regulation. However, some characteristics of the cardiovascular system better match a non-linear self-organized system than a homeostatic one. To determine whether blood pressure regulation is self-organized, we repeated the seminal demonstration of self-organized control of movement, but applied it to the cardiovascular system. We looked for two distinctive features peculiar to self-organization: non-equilibrium phase transitions and hysteresis in their occurrence when the system is challenged. We challenged the cardiovascular system by means of slow, 20-min Tilt-Up and Tilt-Down tilt table tests in random order. We continuously determined the phase between oscillations at the breathing frequency of Total Peripheral Resistances and Heart Rate Variability by means of cross-spectral analysis. We looked for a significant phase drift during these procedures, which signed a non-equilibrium phase transition. We determined at which head-up tilt angle it occurred. We checked that this angle was significantly different between Tilt-Up and Tilt-Down to demonstrate hysteresis. We observed a significant non-equilibrium phase transition in nine healthy volunteers out of 11 with significant hysteresis (48.1 ± 7.5° and 21.8 ± 3.9° during Tilt-Up and Tilt-Down, respectively, p < 0.05). Our study shows experimental evidence of self-organized short-term blood pressure regulation. It provides new insights into blood pressure regulation and its related disorders. PMID:27065880

  10. 12 CFR 217.205 - VaR-based measure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements. The Board-regulated institution must update data sets at least monthly or more frequently as... year. Data used to determine the VaR-based measure must be relevant to the Board-regulated institution.... A Board-regulated institution using this option must update its data more frequently than monthly...

  11. 40 CFR 52.131 - Control Strategy and regulations: Fine Particle Matter.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Control Strategy and regulations: Fine Particle Matter. 52.131 Section 52.131 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Strategy and regulations: Fine Particle Matter. (a) Determination of Attainment: Effective February 6, 2013...

  12. 40 CFR 52.247 - Control Strategy and regulations: Fine Particle Matter.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Control Strategy and regulations: Fine Particle Matter. 52.247 Section 52.247 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Strategy and regulations: Fine Particle Matter. (a) Determination of Attainment: Effective February 8, 2013...

  13. 40 CFR 52.247 - Control Strategy and regulations: Fine Particle Matter.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Control Strategy and regulations: Fine Particle Matter. 52.247 Section 52.247 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Strategy and regulations: Fine Particle Matter. (a) Determination of Attainment: Effective February 8, 2013...

  14. 40 CFR 52.131 - Control Strategy and regulations: Fine Particle Matter.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Control Strategy and regulations: Fine Particle Matter. 52.131 Section 52.131 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Strategy and regulations: Fine Particle Matter. (a) Determination of Attainment: Effective February 6, 2013...

  15. 7 CFR 980.117 - Import regulations; onions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Import regulations; onions. 980.117 Section 980.117... § 980.117 Import regulations; onions. (a) Findings and determinations with respect to onions. (1) Under...; (iii) The marketing of onions can be reasonably distinguished by the seasonal categories, i.e., late...

  16. 7 CFR 980.117 - Import regulations; onions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Import regulations; onions. 980.117 Section 980.117... § 980.117 Import regulations; onions. (a) Findings and determinations with respect to onions. (1) Under...; (iii) The marketing of onions can be reasonably distinguished by the seasonal categories, i.e., late...

  17. 7 CFR 980.117 - Import regulations; onions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Import regulations; onions. 980.117 Section 980.117... § 980.117 Import regulations; onions. (a) Findings and determinations with respect to onions. (1) Under...; (iii) The marketing of onions can be reasonably distinguished by the seasonal categories, i.e., late...

  18. 7 CFR 980.117 - Import regulations; onions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Import regulations; onions. 980.117 Section 980.117... § 980.117 Import regulations; onions. (a) Findings and determinations with respect to onions. (1) Under...; (iii) The marketing of onions can be reasonably distinguished by the seasonal categories, i.e., late...

  19. 43 CFR 17.314 - Age distinctions contained in DOI regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

  20. 43 CFR 17.314 - Age distinctions contained in DOI regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

  1. 43 CFR 17.314 - Age distinctions contained in DOI regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

  2. 43 CFR 17.314 - Age distinctions contained in DOI regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

  3. 43 CFR 17.314 - Age distinctions contained in DOI regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

  4. 77 FR 9520 - Airworthiness Directives; Bombardier Inc., Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... a report of deformation at the neck of the pressure regulator body on certain oxygen cylinder and regulator assemblies (CRA). This AD requires an inspection to determine if a certain oxygen CRA is installed and the replacement of oxygen CRAs containing pressure regulators having a certain part number. We are...

  5. 77 FR 60948 - Stress Testing of Regulated Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... the stress test. F. Post-Assessment Actions by Regulated Entities--Proposed Sec. 1238.6 Section 1238.6... during each quarter of the stress test planning horizon, for each scenario: (1) Potential losses, pre... regulated by a primary federal financial regulatory agency, to conduct annual stress tests to determine...

  6. When neonatal ICU infants participate in research: special protections for special subjects.

    PubMed

    Thomas, Karen A

    2009-06-01

    Neonatal ICU research poses unique concerns for infants and parents. Children are considered a vulnerable research population. Federal regulations specify special protections when children participate in research. These regulations determine the types of research approvable for children based on the balance of risks and benefit. Risk also determines whether one or both parents' consent is required for their infant's participation in research.

  7. The IMD innate immunity pathway of Drosophila influences somatic sex determination via regulation of the Doa locus.

    PubMed

    Zhao, Yunpo; Cocco, Claudia; Domenichini, Severine; Samson, Marie-Laure; Rabinow, Leonard

    2015-11-15

    The IMD pathway induces the innate immune response to infection by gram-negative bacteria. We demonstrate strong female-to-male sex transformations in double mutants of the IMD pathway in combination with Doa alleles. Doa encodes a protein kinase playing a central role in somatic sex determination through its regulation of alternative splicing of dsx transcripts. Transcripts encoding two specific Doa isoforms are reduced in Rel null mutant females, supporting our genetic observations. A role for the IMD pathway in somatic sex determination is further supported by the induction of female-to-male sex transformations by Dredd mutations in sensitized genetic backgrounds. In contrast, mutations in either dorsal or Dif, the two other NF-κB paralogues of Drosophila, display no effects on sex determination, demonstrating the specificity of IMD signaling. Our results reveal a novel role for the innate immune IMD signaling pathway in the regulation of somatic sex determination in addition to its role in response to microbial infection, demonstrating its effects on alternative splicing through induction of a crucial protein kinase. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Does Self-Regulated Learning-Skills Training Improve High-School Students' Self-Regulation, Math Achievement, and Motivation While Using an Intelligent Tutor?

    ERIC Educational Resources Information Center

    Barrus, Angela

    2013-01-01

    This study empirically evaluated the effectiveness of the instructional design, learning tools, and role of the teacher in three versions of a semester-long, high-school remedial Algebra I course to determine what impact self-regulated learning skills and learning pattern training have on students' self-regulation, math achievement, and…

  9. New GMO regulations for old: Determining a new future for EU crop biotechnology

    PubMed Central

    2017-01-01

    ABSTRACT In this review, current EU GMO regulations are subjected to a point-by point analysis to determine their suitability for agriculture in modern Europe. Our analysis concerns present GMO regulations as well as suggestions for possible new regulations for genome editing and New Breeding Techniques (for which no regulations presently exist). Firstly, the present GMO regulations stem from the early days of recombinant DNA and are not adapted to current scientific understanding on this subject. Scientific understanding of GMOs has changed and these regulations are now, not only unfit for their original purpose, but, the purpose itself is now no longer scientifically valid. Indeed, they defy scientific, economic, and even common, sense. A major EU regulatory preconception is that GM crops are basically different from their parent crops. Thus, the EU regulations are “process based” regulations that discriminate against GMOs simply because they are GMOs. However current scientific evidence shows a blending of classical crops and their GMO counterparts with no clear demarcation line between them. Canada has a “product based” approach and determines the safety of each new crop variety independently of the process used to obtain it. We advise that the EC re-writes it outdated regulations and moves toward such a product based approach.  Secondly, over the last few years new genomic editing techniques (sometimes called New Breeding Techniques) have evolved. These techniques are basically mutagenesis techniques that can generate genomic diversity and have vast potential for crop improvement. They are not GMO based techniques (any more than mutagenesis is a GMO technique), since in many cases no new DNA is introduced. Thus they cannot simply be lumped together with GMOs (as many anti-GMO NGOs would prefer). The EU currently has no regulations to cover these new techniques. In this review, we make suggestions as to how these new gene edited crops may be regulated. The EU is at a turning point where the wrong decision could destroy European agricultural competitively for decades to come. PMID:28278120

  10. California's privacy pileup. New state laws meet even newer federal regulations.

    PubMed

    Dimick, Chris

    2009-08-01

    In California, teasing apart state and federal breach notification laws highlights the challenges organizations everywhere face in determining their responsibilities under ARRA's new privacy regulations.

  11. 77 FR 13013 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... Organization Government Procurement Agreement and the Free Trade Agreements, as determined by the United States... 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System...

  12. Brief report: emotion regulation and coping as moderators in the relationship between personality and self-injury.

    PubMed

    Hasking, Penelope A; Coric, Sarah J; Swannell, Sarah; Martin, Graham; Thompson, Holly Knox; Frost, Aaron D J

    2010-10-01

    Self-injury without conscious suicidal intent is an increasingly prevalent phenomenon particularly among adolescent populations. This pilot study examined the extent and correlates of self-injurious behaviour in a school population sample of 393 adolescents (aged 13-18 years) using a self-report questionnaire. Specifically, we aimed to determine whether personality was related to self-injury and whether this relationship was moderated by emotion regulation or coping strategies. Few personality and coping variables were directly related to self-injury after controlling for age and psychopathology. However the relationship between personality and self-injury was moderated by coping skills and emotion regulation. We suggest future research explore these relationships in order to determine the role of coping skills and emotional regulation training in prevention of self-injury.

  13. [Examination related to revised test method for determination of formaldehyde, regulated by the law for the control of household products containing harmful substances].

    PubMed

    Ikarashi, Yoshiaki; Kaniwa, Masa-aki; Tsuchiya, Toshie

    2003-01-01

    In Japan, the amount of formaldehyde in textile products was regulated by the low for the control of household products containing harmful substances. Formaldehyde was determined by measuring the optical density of acetylacetone derivative of formaldehyde extracted from textiles. The household products low stated that the increase in the optical density of color development of the extract from the textile products for babies or infants within 24 months after birth should not be more than 0.05. Collaborative study decided the amount of formaldehyde equivalent to the increase in absorbance described above, and the amount was 16 ppm. There are some reports that formaldehyde causes an allergic reaction even at a very low concentration, so continuous regulation for formaldehyde in the textiles was desirable using this level of amount. We developed HPLC method for the determination of formaldehyde in textile products. Formaldehyde was determined by the direct injection of acetylacetone derivative of samples into the system equipped with ODS column and UV-VIS detector (detection wavelength 413 nm) using the mixture of acetonitrile and water as mobile phase. The linearity was obtained between a peak area or height and the concentrations of formaldehyde solution in the range of 0.0625-2 micrograms/ml. The regulation level was sufficiently detected by the present HPLC method. We recommended that the HPLC test was adopted as a reexamination method for the products may violate the regulation as well as a dimedone test.

  14. 75 FR 35127 - Hazardous and Solid Waste Management System; Identification and Listing of Special Wastes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...The Environmental Protection Agency (EPA or Agency) is proposing to regulate for the first time, coal combustion residuals (CCRs) under the Resource Conservation and Recovery Act (RCRA) to address the risks from the disposal of CCRs generated from the combustion of coal at electric utilities and independent power producers. However, the Agency is considering two options in this proposal and, thus, is proposing two alternative regulations. Under the first proposal, EPA would reverse its August 1993 and May 2000 Bevill Regulatory Determinations regarding coal combustion residuals (CCRs) and list these residuals as special wastes subject to regulation under subtitle C of RCRA, when they are destined for disposal in landfills or surface impoundments. Under the second proposal, EPA would leave the Bevill determination in place and regulate disposal of such materials under subtitle D of RCRA by issuing national minimum criteria. Under both alternatives EPA is proposing to establish dam safety requirements to address the structural integrity of surface impoundments to prevent catastrophic releases. EPA is not proposing to change the May 2000 Regulatory Determination for beneficially used CCRs, which are currently exempt from the hazardous waste regulations under Section 3001(b)(3)(A) of RCRA. However, EPA is clarifying this determination and seeking comment on potential refinements for certain beneficial uses. EPA is also not proposing to address the placement of CCRs in mines, or non-minefill uses of CCRs at coal mine sites in this action.

  15. The role of self-determined motivation in the understanding of exercise-related behaviours, cognitions and physical self-evaluations.

    PubMed

    Thøgersen-Ntoumani, Cecilie; Ntoumanis, Nikos

    2006-04-01

    Grounded in self-determination theory (Deci & Ryan, 1985), the purpose of the present study was to examine whether amotivation, self-determined and controlling types of motivation could predict a range of exercise-related behaviours, cognitions and physical self-evaluations. Exercisers (n = 375) from ten health clubs in the North of England completed questionnaires measuring exercise motivation, exercise stages of change, number of relapses from exercise, future intention to exercise, barriers self-efficacy, physical self-worth and social physique anxiety. Controlling for age and sex, multiple and logistic regression analyses supported our hypotheses by showing self-determined motivation (i.e. intrinsic motivation and identified regulation) to predict more adaptive behavioural, cognitive and physical self-evaluation patterns than external regulation and amotivation. Introjected regulation was related to both adaptive and maladaptive outcomes. Furthermore, a multivariate analysis of variance revealed that exercisers in the maintenance stage of change displayed significantly more self-determined motivation to exercise than those in the preparation and action stages. The results illustrate the importance of promoting self-determined motivation in exercisers to improve the quality of their experiences, as well as to foster their exercise behaviour. Future research should examine the mechanisms that promote self-determined motivation in exercise.

  16. Heart Disease in Women: Unappreciated Challenges, GPER as a New Target.

    PubMed

    Feldman, Ross D

    2016-05-18

    Heart disease in women remains underappreciated, underdiagnosed and undertreated. Further, although we are starting to understand some of the social and behavioral determinants for this, the biological basis for the increased rate of rise in atherosclerosis risk in women after menopause remains very poorly understand. In this review we will outline the scope of the clinical issues related to heart disease in women, the emerging findings regarding the biological basis underlying the increased prevalence of atherosclerotic risk factors in postmenopausal women (vs. men) and the role of the G protein-coupled estrogen receptor (GPER) and its genetic regulation as a determinant of these sex-specific risks. GPER is a recently appreciated GPCR that mediates the rapid effects of estrogen and aldosterone. Recent studies have identified that GPER activation regulates both blood pressure. We have shown that regulation of GPER function via expression of a hypofunctional GPER genetic variant is an important determinant of blood pressure and risk of hypertension in women. Further, our most recent studies have identified that GPER activation is an important regulator of low density lipoprotein (LDL) receptor metabolism and that expression of the hypofunctional GPER genetic variant is an important contributor to the development of hypercholesterolemia in women. GPER appears to be an important determinant of the two major risk factors for coronary artery disease-blood pressure and LDL cholesterol. Further, the importance of this mechanism appears to be greater in women. Thus, the appreciation of the role of GPER function as a determinant of the progression of atherosclerotic disease may be important both in our understanding of cardiometabolic function but also in opening the way to greater appreciation of the sex-specific regulation of atherosclerotic risk factors.

  17. Cell fate determination by ubiquitin-dependent regulation of translation

    PubMed Central

    Werner, Achim; Iwasaki, Shintaro; McGourty, Colleen; Medina-Ruiz, Sofia; Teerikorpi, Nia; Fedrigo, Indro; Ingolia, Nicholas T.; Rape, Michael

    2015-01-01

    Metazoan development depends on accurate execution of differentiation programs that allow pluripotent stem cells to adopt specific fates 1. Differentiation requires changes to chromatin architecture and transcriptional networks, yet whether other regulatory events support cell fate determination is less well understood. Here, we have identified the vertebrate-specific ubiquitin ligase CUL3KBTBD8 as an essential regulator of neural crest specification. CUL3KBTBD8 monoubiquitylates NOLC1 and its paralog TCOF1, whose mutation underlies the neurocristopathy Treacher Collins Syndrome 2,3. Ubiquitylation drives formation of a TCOF1-NOLC1 platform that connects RNA polymerase I with ribosome modification enzymes and remodels the translational program of differentiating cells in favor of neural crest specification. We conclude that ubiquitin-dependent regulation of translation is an important feature of cell fate determination. PMID:26399832

  18. A Self-determination Theory approach to the study of body image concerns, self-presentation and self-perceptions in a sample of aerobic instructors.

    PubMed

    Thøgersen-Ntoumani, Cecilie; Ntoumanis, Nikos

    2007-03-01

    This study examined motivational predictors of body image concerns, self-presentation and self-perceptions using Self-determination Theory as a guiding framework. Aerobic instructors (N = 149) completed questionnaires measuring general need satisfaction, exercise motivational regulations, body image concerns, social physique anxiety and self-perceptions. Introjected regulation predicted all outcome variables in the expected direction. Intrinsic motivation positively predicted physical self-worth. Further, autonomy need satisfaction negatively predicted body image concerns. Finally, differences existed in need satisfaction, introjected regulation, self-perceptions and social physique anxiety between those at risk of developing eating disorders and those not at risk. The results underline the importance of overall and exercise-specific feelings of self-determination in dealing with body image concerns and low self-perceptions of aerobics instructors.

  19. Driver self-regulation and depressive symptoms in cataract patients awaiting surgery: a cross-sectional study

    PubMed Central

    2013-01-01

    Background Cataract is an extremely common visual condition of ageing. Evidence suggests that visual impairment influences driving patterns and self-regulatory behavior among older drivers. However, little is known about the psychological effects of driver self-regulation among older drivers. Therefore, this study aimed to describe driver self-regulation practices among older bilateral cataract patients and to determine the association between self-regulation and depressive symptoms. Methods Ninety-nine older drivers with bilateral cataract were assessed the week before first eye cataract surgery. Driver self-regulation was measured via the Driving Habits Questionnaire. Depressive symptoms were assessed using the 20-item Center for Epidemiological Studies Depression Scale. Visual, demographic and cognitive data were also collected. Differences between self-regulators and non self-regulators were described and linear regression modeling used to determine the association between driver self-regulation and depressive symptoms score. Results Among cataract patients, 48% reported self-regulating their driving to avoid at least one challenging situation. The situations most commonly avoided were driving at night (40%), on the freeway (12%), in the rain (9%) and parallel parking (8%). Self-regulators had significantly poorer contrast sensitivity in their worse eye than non self-regulators (p = 0.027). Driver self-regulation was significantly associated with increased depressive symptoms after controlling for potential confounding factors (p = 0.002). Conclusions Driver self-regulation was associated with increased depressive symptoms among cataract patients. Further research should investigate this association among the general older population. Self-regulation programs aimed at older drivers may need to incorporate mental health elements to counteract unintended psychological effects. PMID:24016307

  20. Motivation as a determinant of physical activity in patients with rheumatoid arthritis.

    PubMed

    Hurkmans, E J; Maes, S; de Gucht, V; Knittle, K; Peeters, A J; Ronday, H K; Vlieland, T P M Vliet

    2010-03-01

    A sufficient level of physical activity is important in reducing the impact of disease in rheumatoid arthritis (RA) patients. According to self-determination theory, the achievement and maintenance of physical activity is related to goal setting and ownership, which can be supported by health professionals. Our objective was to examine the association between physical activity and the extent to which RA patients 1) believe that physical activity is a goal set by themselves (autonomous regulation) or by others (coerced regulation) and 2) feel supported by rheumatologists (autonomy supportiveness). A random selection of 643 RA patients from the outpatient clinics of 3 hospitals were sent a postal survey to assess current physical activity level (Short Questionnaire to Assess Health-Enhancing Physical Activity), regulation style (Treatment Self-Regulation Questionnaire), and the autonomy supportiveness of their rheumatologists (modified Health Care Climate Questionnaire). Of the 271 patients (42%) who returned the questionnaire, 178 (66%) were female, their mean +/- SD age was 62 +/- 14 years, and their mean +/- SD disease duration was 10 +/- 8 years. Younger age, female sex, higher education level, shorter disease duration, lower disease activity, and a more autonomous regulation were univariately associated with more physical activity. Hierarchical multiple regression analyses demonstrated that younger age and a more autonomous regulation were significantly associated with a higher physical activity level (P = 0.000 and 0.050, respectively). Regulation style was a significant determinant of physical activity in RA patients. This finding may contribute to further development of interventions to enhance physical activity in RA patients.

  1. 25 CFR 518.5 - What process will the Commission use to review petitions?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROVISIONS SELF REGULATION OF CLASS II GAMING § 518.5 What process will the Commission use to review petitions? (a) The Chairman shall appoint one Commissioner to administer the Office of Self Regulation. The Office of Self Regulation shall undertake an initial review of the petition to determine whether the...

  2. 25 CFR 1000.223 - When can a Tribe/Consortium request a waiver of a regulation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regulation? 1000.223 Section 1000.223 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.223 When can a Tribe/Consortium...

  3. 7 CFR 301.52-4 - Issuance and cancellation of certificates and permits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrator to allow the interstate movement of regulated articles for scientific purposes under such...) Certificates may be issued for any regulated articles by any inspector if he determines that they are eligible... applicable to such articles and: (1) Have originated in noninfested premises in a regulated area and have not...

  4. Investigating Postsecondary Self-Regulated Learning Instructional Practices: The Development of the Self-Regulated Learning Observation Protocol

    ERIC Educational Resources Information Center

    Hoops, Leah D.; Yu, Shirley L.; Wang, Qianqian; Hollyer, Virginia L.

    2016-01-01

    Promoting students' self-regulated learning (SRL) is one way to improve postsecondary student success. However, few studies have investigated the instructional practices of postsecondary instructors that may support students' SRL. This study sought to fill this gap. An undergraduate mathematics course was observed to determine instruction utilized…

  5. 77 FR 4661 - Revisions of Regulations Concerning Procedures for Filing Initial FOIA Requests

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... NATIONAL LABOR RELATIONS BOARD 29 CFR Part 102 Revisions of Regulations Concerning Procedures for... National Labor Relations Board (NLRB or Board) is amending regulations concerning the procedures for filing... determination was made by the NLRB FOIA Officer concerning records located in the Office of the General Counsel...

  6. 7 CFR 301.52-4 - Issuance and cancellation of certificates and permits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrator to allow the interstate movement of regulated articles for scientific purposes under such...) Certificates may be issued for any regulated articles by any inspector if he determines that they are eligible... applicable to such articles and: (1) Have originated in noninfested premises in a regulated area and have not...

  7. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any age...

  8. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any age...

  9. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any age...

  10. 45 CFR 91.18 - Age distinctions contained in HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Age distinctions contained in HHS regulations. 91... NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM HHS Standards for Determining Age Discrimination § 91.18 Age distinctions contained in HHS regulations. Any age...

  11. 77 FR 22185 - Golden Nematode; Removal of Regulated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ..., without change, an interim rule that amended the golden nematode regulations by removing the townships of... that the fields in these two townships are free of golden nematode, and we determined that regulation... the townships of Elba and Byron in Genesee County, NY, from the list of generally infested areas. \\1...

  12. Federal Regulation and Higher Education. ERIC/Higher Education Research Report Number 1.

    ERIC Educational Resources Information Center

    Bender, Louis W.

    Federal funds are an essential component to the fiscal vitality of higher education; however, in recent years the award of these funds has been contingent on complying with federal regulations. This monograph explores the nature of regulatory practices to determine if federal regulations have altered governance patterns or infringed on…

  13. Measuring Self-Regulation in Self-Paced Open and Distance Learning Environments

    ERIC Educational Resources Information Center

    Kocdar, Serpil; Karadeniz, Abdulkadir; Bozkurt, Aras; Buyuk, Koksal

    2018-01-01

    Previous studies have described many scales for measuring self-regulation; however, no scale has been developed specifically for self-paced open and distance learning environments. Therefore, the aim of this study is to develop a scale for determining the self-regulated learning skills of distance learners in selfpaced open and distance learning…

  14. 76 FR 23520 - Periodic Review of Existing Regulations; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... reviews that regulation to determine if the underlying science and policy are still valid and whether the regulations should be updated based on current science, policy, data, or technology. The third mechanism is... charged FDA with encouraging more research and development for treatments specifically for children. In...

  15. The effects of instructors' autonomy support and students' autonomous motivation on learning organic chemistry: A self-determination theory perspective

    NASA Astrophysics Data System (ADS)

    Black, Aaron E.; Deci, Edward L.

    2000-11-01

    This prospective study applied self-determination theory to investigate the effects of students' course-specific self-regulation and their perceptions of their instructors' autonomy support on adjustment and academic performance in a college-level organic chemistry course. The study revealed that: (1) students' reports of entering the course for relatively autonomous (vs. controlled) reasons predicted higher perceived competence and interest/enjoyment and lower anxiety and grade-focused performance goals during the course, and were related to whether or not the students dropped the course; and (2) students' perceptions of their instructors' autonomy support predicted increases in autonomous self-regulation, perceived competence, and interest/enjoyment, and decreases in anxiety over the semester. The change in autonomous self-regulation in turn predicted students' performance in the course. Further, instructor autonomy support also predicted course performance directly, although differences in the initial level of students' autonomous self-regulation moderated that effect, with autonomy support relating strongly to academic performance for students initially low in autonomous self-regulation but not for students initially high in autonomous self-regulation.

  16. Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila

    PubMed Central

    Li, Qian; Zhang, Xuchen; Liang, Xitong; Zhang, Fang; Wang, Lianzhang; Zhong, Yi

    2016-01-01

    Translocation of signaling molecules, MAPK in particular, from the cytosol to nucleus represents a universal key element in initiating the gene program that determines memory consolidation. Translocation mechanisms and their behavioral impact, however, remain to be determined. Here, we report that a highly conserved nuclear transporter, Drosophila importin-7 (DIM-7), regulates import of training-activated MAPK for consolidation of long-term memory (LTM). We show that silencing DIM-7 functions results in impaired LTM, whereas overexpression of DIM-7 enhances LTM. This DIM-7–dependent regulation of LTM is confined to a consolidation time window and in mushroom body neurons. Image data show that bidirectional alteration in DIM-7 expression results in proportional changes in the intensity of training-activated MAPK accumulated within the nuclei of mushroom body neurons during LTM consolidation. Such DIM-7–regulated nuclear accumulation of activated MAPK is observed only in the training specified for LTM induction and determines the amplitude, but not the time course, of memory consolidation. PMID:26929354

  17. The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice.

    PubMed

    Li, Shuangcheng; Gao, Fengyan; Xie, Kailong; Zeng, Xiuhong; Cao, Ye; Zeng, Jing; He, Zhongshan; Ren, Yun; Li, Wenbo; Deng, Qiming; Wang, Shiquan; Zheng, Aiping; Zhu, Jun; Liu, Huainian; Wang, Lingxia; Li, Ping

    2016-11-01

    Grain weight is the most important component of rice yield and is mainly determined by grain size, which is generally controlled by quantitative trait loci (QTLs). Although numerous QTLs that regulate grain weight have been identified, the genetic network that controls grain size remains unclear. Herein, we report the cloning and functional analysis of a dominant QTL, grain length and width 2 (GLW2), which positively regulates grain weight by simultaneously increasing grain length and width. The GLW2 locus encodes OsGRF4 (growth-regulating factor 4) and is regulated by the microRNA miR396c in vivo. The mutation in OsGRF4 perturbs the OsmiR396 target regulation of OsGRF4, generating a larger grain size and enhanced grain yield. We also demonstrate that OsGIF1 (GRF-interacting factors 1) directly interacts with OsGRF4, and increasing its expression improves grain size. Our results suggest that the miR396c-OsGRF4-OsGIF1 regulatory module plays an important role in grain size determination and holds implications for rice yield improvement. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  18. 75 FR 48627 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Transportation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... conflict resolution associated with conformity determinations (COMAR 26.11.26.06). EPA has determined that... regulation regarding conflict resolution associated with conformity determinations. Therefore, EPA is...

  19. 7 CFR 1207.511 - Determination of assessable quantity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... POTATO RESEARCH AND PROMOTION PLAN Rules and Regulations Assessments § 1207.511 Determination of assessable quantity. The assessable quantity of potatoes in any lot shall be determined on the basis of...

  20. 7 CFR 1207.511 - Determination of assessable quantity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... POTATO RESEARCH AND PROMOTION PLAN Rules and Regulations Assessments § 1207.511 Determination of assessable quantity. The assessable quantity of potatoes in any lot shall be determined on the basis of...

  1. 7 CFR 1207.511 - Determination of assessable quantity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... POTATO RESEARCH AND PROMOTION PLAN Rules and Regulations Assessments § 1207.511 Determination of assessable quantity. The assessable quantity of potatoes in any lot shall be determined on the basis of...

  2. Patterns and Mechanisms of Evolutionary Transitions between Genetic Sex-Determining Systems

    PubMed Central

    Sander van Doorn, G.

    2014-01-01

    The diversity and patchy phylogenetic distribution of genetic sex-determining mechanisms observed in some taxa is thought to have arisen by the addition, modification, or replacement of regulators at the upstream end of the sex-determining pathway. Here, I review the various evolutionary forces acting on upstream regulators of sexual development that can cause transitions between sex-determining systems. These include sex-ratio selection and pleiotropic benefits, as well as indirect selection mechanisms involving sex-linked sexually antagonistic loci or recessive deleterious mutations. Most of the current theory concentrates on the population–genetic aspects of sex-determination transitions, using models that do not reflect the developmental mechanisms involved in sex determination. However, the increasing availability of molecular data creates opportunities for the development of mechanistic models that can clarify how selection and developmental architecture interact to direct the evolution of sex-determination genes. PMID:24993578

  3. 76 FR 16700 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Regulation and Regulatory Review,'' the Department of Defense invites public comments on how it can change... to determine how its regulations can increase efficiency, transparency, and provide accountability...

  4. 33 CFR 161.6 - Preemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations in this part have preemptive impact over State laws or regulations on the same subject matter. The Coast Guard has determined, after considering the factors developed by the Supreme Court in U.S. v...

  5. Employees with Sleep Disorders

    MedlinePlus

    ... definition of disability that each person must meet (EEOC Regulations . . ., 2011). Therefore, some people with sleep disorders will ... impairment, or is regarded as having an impairment (EEOC Regulations . . . , 2011). For more information about how to determine ...

  6. Employees with Chronic Pain

    MedlinePlus

    ... definition of disability that each person must meet (EEOC Regulations . . ., 2011). Therefore, some people with chronic pain will ... impairment, or is regarded as having an impairment (EEOC Regulations . . . , 2011). For more information about how to determine ...

  7. Approaches for Investigating Translational Regulation Controlled by PARP1: Biotin-Based UV Cross-Linking and Luciferase Reporter Assay.

    PubMed

    Ji, Yingbiao

    2017-01-01

    The RNA-binding proteins (RBPs) play a pivotal role in controlling gene expression through posttranscriptional processes. As the trans-acting factors, RBPs interact with the cis-regulatory elements located within mRNAs to regulate mRNA translational efficiency. Adding a new-layer regulation, recent studies suggest that poly(ADP-ribosyl)ation of the RNA-binding proteins often inhibit the RNA-binding ability of RBPs, thus regulating RBP-dependent mRNA metabolism including translational control. Here, we describe a biotin-based UV cross-linking method to determine if excessive accumulation of pADPr in the cell disrupts the interaction between RBPs and their target mRNAs. In addition, we illustrate the protocol of using the luciferase reporter assay to determine the effect of poly(ADP-ribosyl)ation on mRNA translation.

  8. Regulation of alternative splicing at the single-cell level.

    PubMed

    Faigenbloom, Lior; Rubinstein, Nimrod D; Kloog, Yoel; Mayrose, Itay; Pupko, Tal; Stein, Reuven

    2015-12-28

    Alternative splicing is a key cellular mechanism for generating distinct isoforms, whose relative abundances regulate critical cellular processes. It is therefore essential that inclusion levels of alternative exons be tightly regulated. However, how the precision of inclusion levels among individual cells is governed is poorly understood. Using single-cell gene expression, we show that the precision of inclusion levels of alternative exons is determined by the degree of evolutionary conservation at their flanking intronic regions. Moreover, the inclusion levels of alternative exons, as well as the expression levels of the transcripts harboring them, also contribute to this precision. We further show that alternative exons whose inclusion levels are considerably changed during stem cell differentiation are also subject to this regulation. Our results imply that alternative splicing is coordinately regulated to achieve accuracy in relative isoform abundances and that such accuracy may be important in determining cell fate. © 2015 The Authors. Published under the terms of the CC BY 4.0 license.

  9. 32 CFR 1900.43 - Determination(s) by Deputy Director(s).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Determination(s) by Deputy Director(s). 1900.43 Section 1900.43 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE... Administrative Appeals § 1900.43 Determination(s) by Deputy Director(s). Each Deputy Director in charge of a...

  10. Cell-fate determination by ubiquitin-dependent regulation of translation.

    PubMed

    Werner, Achim; Iwasaki, Shintaro; McGourty, Colleen A; Medina-Ruiz, Sofia; Teerikorpi, Nia; Fedrigo, Indro; Ingolia, Nicholas T; Rape, Michael

    2015-09-24

    Metazoan development depends on the accurate execution of differentiation programs that allow pluripotent stem cells to adopt specific fates. Differentiation requires changes to chromatin architecture and transcriptional networks, yet whether other regulatory events support cell-fate determination is less well understood. Here we identify the ubiquitin ligase CUL3 in complex with its vertebrate-specific substrate adaptor KBTBD8 (CUL3(KBTBD8)) as an essential regulator of human and Xenopus tropicalis neural crest specification. CUL3(KBTBD8) monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. Ubiquitylation drives formation of a TCOF1-NOLC1 platform that connects RNA polymerase I with ribosome modification enzymes and remodels the translational program of differentiating cells in favour of neural crest specification. We conclude that ubiquitin-dependent regulation of translation is an important feature of cell-fate determination.

  11. 20 CFR 652.8 - Administrative provisions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... determination. Such determinations shall be based on the requirements of the Act, regulations, and State plan. (i) The initial determination shall identify the audit findings, state the Secretary's proposed determination of the allowability of questioned costs and activities, and provide for informal resolution of...

  12. 49 CFR 384.309 - Results of compliance determination.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Results of compliance determination. 384.309 Section 384.309 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... Results of compliance determination. (a) A State shall be determined not substantially in compliance with...

  13. 49 CFR 384.309 - Results of compliance determination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Results of compliance determination. 384.309 Section 384.309 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... Results of compliance determination. (a) A State shall be determined not substantially in compliance with...

  14. 49 CFR 384.309 - Results of compliance determination.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Results of compliance determination. 384.309 Section 384.309 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... Results of compliance determination. (a) A State shall be determined not substantially in compliance with...

  15. 49 CFR 384.309 - Results of compliance determination.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Results of compliance determination. 384.309 Section 384.309 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... Results of compliance determination. (a) A State shall be determined not substantially in compliance with...

  16. 49 CFR 384.309 - Results of compliance determination.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Results of compliance determination. 384.309 Section 384.309 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... Results of compliance determination. (a) A State shall be determined not substantially in compliance with...

  17. Tribolium castaneum Transformer-2 regulates sex determination and development in both males and females

    PubMed Central

    Shukla, Jayendra Nath; Palli, Subba Reddy

    2014-01-01

    Tribolium castaneum Transformer (TcTra) is essential for female sex determination and maintenance through the regulation of sex-specific splicing of doublesex (dsx) pre-mRNA. In females, TcTra also regulates the sex-specific splicing of its own pre-mRNA to ensure continuous production of functional Tra protein. Transformer protein is absent in males and hence dsx pre-mRNA is spliced in a default mode. The mechanisms by which males inhibit the production of functional Tra protein are not known. Here, we report on functional characterization of transformer-2 (tra-2) gene (an ortholog of Drosophila transformer-2) in T. castaneum. RNA interference-mediated knockdown in the expression of gene coding for tra-2 in female pupae or adults resulted in the production of male-specific isoform of dsx and both female and male isoforms of tra suggesting that Tra-2 is essential for the female-specific splicing of tra and dsx pre-mRNAs. Interestingly, knockdown of tra-2 in males did not affect the splicing of dsx but resulted in the production of both female and male isoforms of tra suggesting that Tra-2 suppresses female-specific splicing of tra pre-mRNA in males. This dual regulation of sex-specific splicing of tra pre-mRNA ensures a tight regulation of sex determination and maintenance. These data suggest a critical role for Tra-2 in suppression of female sex determination cascade in males. In addition, RNAi studies showed that Tra-2 is also required for successful embryonic and larval development in both sexes. PMID:24056158

  18. 77 FR 2679 - Defense Federal Acquisition Regulation Supplement: Order of Application for Modifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... following methods: [cir] Regulations.gov : http://www.regulations.gov . Submit comments via the Federal e... contract. In order to determine the sequence of modifications to a contract or order, a method for... the numeric order of the modifications to a contract is not the order in which the changes to the...

  19. 25 CFR 1000.224 - How can a Tribe/Consortium expedite the review of a regulation waiver request?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regulation waiver request? 1000.224 Section 1000.224 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.224 How can a...

  20. Examining the Psychometric Properties of the" Emotional Regulation Checklist" in 4- and 5-Year-Old Preschoolers

    ERIC Educational Resources Information Center

    Danisman, Sahin; Iman, Esra Dereli; Demircan, Zeynep Akin; Yaya, Dilara

    2016-01-01

    Introduction: Emotional Regulation Checklist is frequently used to determine emotional developments of children by teacher and parents of children. The purpose of this study was to examining the Psychometric Properties of "Emotional Regulation Check List" for 4-5 years age in preschool children. Method: The sample of the research was…

  1. 7 CFR 301.48-2 - Authorization to designate, and terminate designation of, regulated airports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-2 Authorization to designate, and... State to be a regulated airport when he or she determines that adult populations of Japanese beetle... Japanese beetle and aircraft destined for the States listed in § 301.48(b) may be leaving the airport. (b...

  2. 7 CFR 301.48-2 - Authorization to designate, and terminate designation of, regulated airports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-2 Authorization to designate, and... State to be a regulated airport when he or she determines that adult populations of Japanese beetle... Japanese beetle and aircraft destined for the States listed in § 301.48(b) may be leaving the airport. (b...

  3. 7 CFR 301.48-2 - Authorization to designate, and terminate designation of, regulated airports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-2 Authorization to designate, and... State to be a regulated airport when he or she determines that adult populations of Japanese beetle... Japanese beetle and aircraft destined for the States listed in § 301.48(b) may be leaving the airport. (b...

  4. Self-Regulated Learning Strategies and Pre-University Math Performance of International Students in Malaysia

    ERIC Educational Resources Information Center

    Loong, Tang Eng

    2012-01-01

    This study is an attempt to compare the use of self-regulated learning strategies and their math performance between home and international students in the Monash University Foundation Year (MUFY) and determine the self-regulated learning strategies that are significantly associated with their math performance. The participants of the study were…

  5. 7 CFR 301.48-2 - Authorization to designate, and terminate designation of, regulated airports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-2 Authorization to designate, and... State to be a regulated airport when he or she determines that adult populations of Japanese beetle... Japanese beetle and aircraft destined for the States listed in § 301.48(b) may be leaving the airport. (b...

  6. 78 FR 76056 - Revocation of Class E Airspace; Danville, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Danville, IL. The FAA has determined that, because of changes in the composition of flight operations at... that this regulation only involves an established body of technical regulations for which frequent and...

  7. Have studies of the developmental regulation of behavioral phenotypes revealed the mechanisms of gene-environment interactions?

    PubMed Central

    Hall, F. Scott; Perona, Maria T. G.

    2012-01-01

    This review addresses the recent convergence of our long-standing knowledge of the regulation of behavioral phenotypes by developmental experience with recent advances in our understanding of mechanisms regulating gene expression. This review supports a particular perspective on the developmental regulation of behavioral phenotypes: That the role of common developmental experiences (e.g. maternal interactions, peer interactions, exposure to a complex environment, etc.) is to fit individuals to the circumstances of their lives within bounds determined by long-standing (evolutionary) mechanisms that have shaped responses to critical and fundamental types of experience via those aspects of gene structure that regulate gene expression. The phenotype of a given species is not absolute for a given genotype but rather variable within bounds that are determined by mechanisms regulated by experience (e.g. epigenetic mechanisms). This phenotypic variation is not necessarily random, or evenly distributed along a continuum of description or measurement, but often highly disjointed, producing distinct, even opposing, phenotypes. The potentiality for these varying phenotypes is itself the product of evolution, the potential for alternative phenotypes itself conveying evolutionary advantage. Examples of such phenotypic variation, resulting from environmental or experiential influences, have a long history of study in neurobiology, and a number of these will be discussed in this review: neurodevelopmental experiences that produce phenotypic variation in visual perception, cognitive function, and emotional behavior. Although other examples will be discussed, particular emphasis will be made on the role of social behavior on neurodevelopment and phenotypic determination. It will be argued that an important purpose of some aspects of social behavior is regulation of neurobehavioral phenotypes by experience via genetic regulatory mechanisms. PMID:22643448

  8. Potential Regulators Driving the Transition in Nonalcoholic Fatty Liver Disease: a Stage-Based View.

    PubMed

    Lou, Yi; Chen, Yi-Dan; Sun, Fu-Rong; Shi, Jun-Ping; Song, Yu; Yang, Jin

    2017-01-01

    The incidence of nonalcoholic fatty liver disease (NAFLD), ranging from mild steatosis to hepatocellular injury and inflammation, increases with the rise of obesity. However, the implications of transcription factors network in progressive NAFLD remain to be determined. A co-regulatory network approach by combining gene expression and transcription influence was utilized to dissect transcriptional regulators in different NAFLD stages. In vivo, mice models of NAFLD were used to investigate whether dysregulated expression be undertaken by transcriptional regulators. Through constructing a large-scale co-regulatory network, sample-specific regulator activity was estimated. The combinations of active regulators that drive the progression of NAFLD were identified. Next, top regulators in each stage of NAFLD were determined, and the results were validated using the different experiments and bariatric surgical samples. In particular, Adipocyte enhancer-binding protein 1 (AEBP1) showed increased transcription activity in nonalcoholic steatohepatitis (NASH). Further characterization of the AEBP1 related transcription program defined its co-regulators, targeted genes, and functional organization. The dynamics of AEBP1 and its potential targets were verified in an animal model of NAFLD. This study identifies putative functions for several transcription factors in the pathogenesis of NAFLD and may thus point to potential targets for therapeutic interventions. © 2017 The Author(s) Published by S. Karger AG, Basel.

  9. Down-regulation of Glutathione S-transferase Pi in Asthma Contributes to Enhanced Oxidative Stress

    PubMed Central

    Schroer, Kathy T.; Gibson, Aaron M.; Sivaprasad, Umasundari; Bass, Stacey A.; Ericksen, Mark B.; Wills-Karp, Marsha; LeCras, Tim; Fitzpatrick, Anne M.; Brown, Lou Ann S.; Stringer, Keith F.; Khurana Hershey, Gurjit K.

    2011-01-01

    Background Glutathione S-transferase Pi (GSTPi) is the predominant redox regulator in the lung. While evidence implicates an important role for GSTPi in asthma, the mechanism for this has remained elusive. Objectives To determine how GSTPi is regulated in asthma and to elucidate its role in maintaining redox homeostasis. Methods We elucidated the regulation of GSTPi in children with asthma and utilized murine models of asthma to determine the role of GSTPi in redox homeostasis. Measurements and Main Results Our findings demonstrate that GSTPi transcript levels are markedly down-regulated in allergen and IL-13 treated mouse models of asthma via STAT6 dependent and independent pathways. Nuclear factor-erythroid 2 related factor 2 (Nrf2) was also down-regulated in these models. The decrease in GSTPi expression was associated with decreased total GST activity in the lungs of mice. Examination of cystine intermediates uncovered a functional role for GSTPi in regulating Cys oxidation, whereby GSTPi-deficient mice exhibited increased oxidative stress (increase in % cystine) compared with wild-type mice following allergen challenge. GSTPi expression was similarly down-regulated in children with asthma. Conclusions These data collectively suggest that down-regulation of GSTPi following allergen challenge may contribute to the asthma phenotype due to disruption of redox homeostasis and increased oxidative stress. Furthermore, GSTPi may be an important therapeutic target for asthma, and evaluation of GSTPi expression may prove beneficial in identifying individuals who would benefit from therapy targeting this pathway. PMID:21570714

  10. 7 CFR 51.1416 - Optional determinations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND...

  11. 7 CFR 51.1416 - Optional determinations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND...

  12. National understanding and acceptance of occupant protection systems

    DOT National Transportation Integrated Search

    1986-07-01

    Regulations requiring new cars to be equipped with automatic occupant protection systems unless states representing two-thirds of the population enact mandatory safety belt use regulation by 1989 necessitated a study to determine the public's knowled...

  13. 48 CFR 419.602 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Procedures. 419.602 Section 419.602 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility 419.602...

  14. 48 CFR 1319.602 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Procedures. 1319.602 Section 1319.602 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determination of Responsibility 1319.602...

  15. 47 CFR 97.311 - SS emission types.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... regulated by the FCC and between an area where the amateur service is regulated by the FCC and an amateur... the communication. This shall be determined by the use of the ratio, measured at the receiver, of the...

  16. 77 FR 76215 - Small Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-27

    ... overall goal of simplification and maximization of benefits for small businesses, SBA proposed amendments... franchisee. F. Section 121.704--When SBA Determines Size and Eligibility SBA's proposed regulations for the...

  17. The determinants of alternative RNA splicing in human cells.

    PubMed

    Ramanouskaya, Tatsiana V; Grinev, Vasily V

    2017-12-01

    Alternative splicing represents an important level of the regulation of gene function in eukaryotic organisms. It plays a critical role in virtually every biological process within an organism, including regulation of cell division and cell death, differentiation of tissues in the embryo and the adult organism, as well as in cellular response to diverse environmental factors. In turn, studies of the last decade have shown that alternative splicing itself is controlled by different mechanisms. Unfortunately, there is no clear understanding of how these diverse mechanisms, or determinants, regulate and constrain the set of alternative RNA species produced from any particular gene in every cell of the human body. Here, we provide a consolidated overview of alternative splicing determinants including RNA-protein interactions, epigenetic regulation via chromatin remodeling, coupling of transcription-to-alternative splicing, effect of secondary structures in pre-RNA, and function of the RNA quality control systems. We also extensively and critically discuss some mechanistic insights on coordinated inclusion/exclusion of exons during the formation of mature RNA molecules. We conclude that the final structure of RNA is pre-determined by a complex interplay between cis- and trans-acting factors. Altogether, currently available empirical data significantly expand our understanding of the functioning of the alternative splicing machinery of cells in normal and pathological conditions. On the other hand, there are still many blind spots that require further deep investigations.

  18. Levels of physical activity, motivation and barriers to participation in university students.

    PubMed

    Sevil, Javier; Práxedes, Alba; Abarca-Sos, Alberto; Del Villar, Fernando; García-González, Luis

    2016-10-01

    Grounded in self-determination theory and trans-theoretical model applied to exercise, the aim of this study was to analyse the existing relationships between physical activity (PA) carried out by university students, perceived barriers to PA, motivation to PA and stages of change. 901 Spanish students took part in the study (408 men, 493 women; mean age 22.59±3.59), who completed the Behavioural Regulation in Exercise Questionnaire (BREQ-3), Scale of Barriers to PA, Stages of Change and the International Physical Activity Questionnaire - Short Form (IPAQ-SF). Noteworthy among the findings is the positive relationship between the more autonomous regulation forms, especially integrated regulation, and the moderate to vigorous PA (MVPA) levels. However, barriers to participatrion are negatively related to PA levels and the more self-determined forms of motivation. Finally, students in action and maintenance stages, and those who comply with the recommendations on PA present higher values in the more self-determined motivation forms and lower values in barriers to participation in PA. The study shows the importance of addressing the analysis of variables associated with engagement in PA in the university population to develop healthy policies and intervention programmes that can establish a series of healthy and more active habits in the youth-adult stage. The appropriateness of promoting more self-determined motivation forms is highlighted, especially integrated regulation, to have an impact on higher levels of MVPA.

  19. Distinct mechanisms determine organ left-right asymmetry patterning in an uncoupled way.

    PubMed

    Huang, Sizhou; Xu, Wenming; Su, Bingyin; Luo, Lingfei

    2014-03-01

    Disruption of Nodal in the lateral plate mesoderm (LPM) usually leads to left-right (LR) patterning defects in multiple organs. However, whether the LR patterning of organs is always regulated in a coupled way has largely not yet been elucidated. In addition, whether other crucial regulators exist in the LPM that coordinate with Nodal in regulating organ LR patterning is also undetermined. In this paper, after briefly summarizing the common process of LR patterning, the most puzzling question regarding the initiation of asymmetry is considered and the divergent mechanisms underlying the uncoupled LR patterning in different organs are discussed. On the basis of cases in which different organ LR patterning is determined in an uncoupled way via an independent mechanism or at a different time, we propose that there are other critical factors in the LPM that coordinate with Nodal to regulate heart LR asymmetry patterning during early LR patterning. © 2014 WILEY Periodicals, Inc.

  20. Conserved Insulin Signaling in the Regulation of Oocyte Growth, Development, and Maturation

    PubMed Central

    DAS, DEBABRATA; ARUR, SWATHI

    2017-01-01

    Insulin signaling regulates various aspects of physiology, such as glucose homeostasis and aging, and is a key determinant of female reproduction in metazoans. That insulin signaling is crucial for female reproductive health is clear from clinical data linking hyperinsulinemic and hypoinsulinemic condition with certain types of ovarian dysfunction, such as altered steroidogenesis, polycystic ovary syndrome, and infertility. Thus, understanding the signaling mechanisms that underlie the control of insulin-mediated ovarian development is important for the accurate diagnosis of and intervention for female infertility. Studies of invertebrate and vertebrate model systems have revealed the molecular determinants that transduce insulin signaling as well as which biological processes are regulated by the insulin-signaling pathway. The molecular determinants of the insulin-signaling pathway, from the insulin receptor to its downstream signaling components, are structurally and functionally conserved across evolution, from worms to mammals – yet, physiological differences in signaling still exist. Insulin signaling acts cooperatively with gonadotropins in mammals and lower vertebrates to mediate various aspects of ovarian development, mainly owing to evolution of the endocrine system in vertebrates. In contrast, insulin signaling in Drosophila and Caenorhabditis elegans directly regulates oocyte growth and maturation. In this review, we compare and contrast insulin-mediated regulation of ovarian functions in mammals, lower vertebrates, C. elegans, and Drosophila, and highlight conserved signaling pathways and regulatory mechanisms in general while illustrating insulin’s unique role in specific reproductive processes. PMID:28379636

  1. Motivational processes and well-being in cardiac rehabilitation: a self-determination theory perspective.

    PubMed

    Rahman, Rachel Jane; Hudson, Joanne; Thøgersen-Ntoumani, Cecilie; Doust, Jonathan H

    2015-01-01

    This research examined the processes underpinning changes in psychological well-being and behavioural regulation in cardiac rehabilitation (CR) patients using self-determination theory (SDT). A repeated measures design was used to identify the longitudinal relationships between SDT variables, psychological well-being and exercise behaviour during and following a structured CR programme. Participants were 389 cardiac patients (aged 36-84 years; M(age) = 64 ± 9 years; 34.3% female) referred to a 12-week-supervised CR programme. Psychological need satisfaction, behavioural regulation, health-related quality of life, physical self-worth, anxiety and depression were measured at programme entry, exit and six month post-programme. During the programme, increases in autonomy satisfaction predicted positive changes in behavioural regulation, and improvements in competence and relatedness satisfaction predicted improvements in behavioural regulation and well-being. Competence satisfaction also positively predicted habitual physical activity. Decreases in external regulation and increases in intrinsic motivation predicted improvements in physical self-worth and physical well-being, respectively. Significant longitudinal relationships were identified whereby changes during the programme predicted changes in habitual physical activity and the mental quality of life from exit to six month follow-up. Findings provide insight into the factors explaining psychological changes seen during CR. They highlight the importance of increasing patients' perceptions of psychological need satisfaction and self-determined motivation to improve well-being during the structured component of a CR programme and longer term physical activity.

  2. Arabidopsis LEAFY COTYLEDON1 controls cell fate determination during post-embryonic development

    PubMed Central

    Huang, Mingkun; Hu, Yilong; Liu, Xu; Li, Yuge; Hou, Xingliang

    2015-01-01

    Arabidopsis LEAFY COTYLEDON1 (LEC1) transcription factor is a master regulator that shapes plant embryo development and post-embryonic seedling establishment. Loss-of-function of LEC1 alters the cotyledon identity, causing the formation of ectopic trichomes, which does not occur in wild-type seedlings, implying that LEC1 might regulate embryonic cell fate determination during post-embryonic development. To test this hypothesis, we compared the expression of trichome development-related genes between the wild-type and the lec1 mutant. We observed that transcripts of GLABROUS1 (GL1), GL2, and GL3, genes encoding the positive regulators in trichome development, were significantly upregulated, while the TRICHOMELESS1 (TCL2), ENHANCER OF TRY AND CPC1 (ETC1), and ETC2 genes, encoding the negative regulators in trichome development, were downregulated in the lec1 mutant. Furthermore, overexpression of LEC1 activated the expressions of TCL2, CAPPICE (CPC), and ETC1, resulting in production of cotyledonary leaves with no or fewer trichomes during vegetative development. In addition, we demonstrated that LEC1 interacts with TCL2 in yeast and in vitro. A genetic experiment showed that loss-of-function of GL2 rescued the ectopic trichome formation in the lec1 mutant. These findings strongly support that LEC1 regulates trichome development, providing direct evidence for the role of LEC1 in cell fate determination during post-embryonic development. PMID:26579186

  3. The blood donor identity survey: a multidimensional measure of blood donor motivations.

    PubMed

    France, Christopher R; Kowalsky, Jennifer M; France, Janis L; Himawan, Lina K; Kessler, Debra A; Shaz, Beth H

    2014-08-01

    Evidence indicates that donor identity is an important predictor of donation behavior; however, prior studies have relied on diverse, unidimensional measures with limited psychometric support. The goals of this study were to examine the application of self-determination theory to blood donor motivations and to develop and validate a related multidimensional measure of donor identity. Items were developed and administered electronically to a sample of New York Blood Center (NYBC) donors (n=582) and then to a sample of Ohio University students (n=1005). Following initial confirmatory factor analysis (CFA) on the NYBC sample to identify key items related to self-determination theory's six motivational factors, a revised survey was administered to the university sample to reexamine model fit and to assess survey reliability and validity. Consistent with self-determination theory, for both samples CFAs indicated that the best fit to the data was provided by a six-motivational-factor model, including amotivation, external regulation, introjected regulation, identified regulation, integrated regulation, and intrinsic regulation. The Blood Donor Identity Survey provides a psychometrically sound, multidimensional measure of donor motivations (ranging from unmotivated to donate to increasing levels of autonomous motivation to donate) that is suitable for nondonors as well as donors with varying levels of experience. Future research is needed to examine longitudinal changes in donor identity and its relationship to actual donation behavior. © 2014 AABB.

  4. 48 CFR 2806.302-70 - Determination and findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Determination and findings... Determination and findings. (a) Procedure. The determination and findings (D&F) required by FAR 6.302.7(c)(1... Determination and Findings Authority To Use Other Than Full and Open Competition: Upon the basis of the...

  5. 25 CFR 1000.221 - Can the Secretary grant a waiver of regulations to a Tribe/Consortium?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.221 Can the Secretary grant a... 25 Indians 2 2010-04-01 2010-04-01 false Can the Secretary grant a waiver of regulations to a...

  6. 25 CFR 1000.229 - May a Tribe/Consortium propose a substitute for a regulation it wishes to be waived?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regulation it wishes to be waived? 1000.229 Section 1000.229 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.229 May a Tribe...

  7. Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series).

    PubMed

    Loscalzo, Joseph; Handy, Diane E

    2014-06-01

    Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunities for novel strategies for disease prevention and treatment.

  8. Is Greater Improvement in Early Self-Regulation Associated with Fewer Behavioral Problems Later in Childhood?

    ERIC Educational Resources Information Center

    Sawyer, Alyssa C. P.; Miller-Lewis, Lauren R.; Searle, Amelia K.; Sawyer, Michael G.; Lynch, John W.

    2015-01-01

    The aim of this study was to determine whether the extent of improvement in self-regulation achieved between ages 4 and 6 years is associated with the level of behavioral problems later in childhood. Participants were 4-year-old children (n = 510) attending preschools in South Australia. Children's level of self-regulation was assessed using the…

  9. Assessing the Impact of an Emotion Regulation Booster Program for Elementary School-Aged Children

    ERIC Educational Resources Information Center

    Hammond, Angela; Westhues, Anne; Hanbidge, Alice Schmidt

    2009-01-01

    The purpose of this study was to determine whether children who participated in a booster program 3 years after completing an emotion regulation program show a greater increase between pretest and post-test in the development of emotion regulation skills than children in a comparison group. A booster program was implemented as a pilot project with…

  10. The Influence of Pintrich's Self-Regulated Learning Model on Elementary Teacher Candidates in a Life Science Course

    ERIC Educational Resources Information Center

    Çetin, Baris

    2017-01-01

    The purpose of this research was to determine whether the use of activities based on Pintrich's self-regulated learning model effect the self-regulated learning perceptions of elementary teacher candidates within a Life Science course. The research was organized in accordance with the quasi-experimental designs model. This study was conducted…

  11. 75 FR 41373 - Special Local Regulations for Marine Events; Port Huron to Mackinac Island Sail Race

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ...-AA08 Special Local Regulations for Marine Events; Port Huron to Mackinac Island Sail Race AGENCY: Coast... regulation for the annual Port Huron to Mackinac Island Sail Race. This action is necessary to safely control... the Port Sector Detroit has determined that the start of the Port Huron to Mackinac Island Sail Race...

  12. The Relation between English Learning Students' Levels of Self-Regulation and Metacognitive Skills and Their English Academic Achievements

    ERIC Educational Resources Information Center

    Adigüzel, Abdullah; Orhan, Ali

    2017-01-01

    It is remarkable that there are only a few studies that measures to what extent metacognitive and self-regulation skills affect students' academic achievements in the English lesson. This study is important for identifying the personal variables that have an impact on metacognitive and self-regulation skill and determining the relationship between…

  13. Mechanisms and Evolution of Control Logic in Prokaryotic Transcriptional Regulation

    PubMed Central

    van Hijum, Sacha A. F. T.; Medema, Marnix H.; Kuipers, Oscar P.

    2009-01-01

    Summary: A major part of organismal complexity and versatility of prokaryotes resides in their ability to fine-tune gene expression to adequately respond to internal and external stimuli. Evolution has been very innovative in creating intricate mechanisms by which different regulatory signals operate and interact at promoters to drive gene expression. The regulation of target gene expression by transcription factors (TFs) is governed by control logic brought about by the interaction of regulators with TF binding sites (TFBSs) in cis-regulatory regions. A factor that in large part determines the strength of the response of a target to a given TF is motif stringency, the extent to which the TFBS fits the optimal TFBS sequence for a given TF. Advances in high-throughput technologies and computational genomics allow reconstruction of transcriptional regulatory networks in silico. To optimize the prediction of transcriptional regulatory networks, i.e., to separate direct regulation from indirect regulation, a thorough understanding of the control logic underlying the regulation of gene expression is required. This review summarizes the state of the art of the elements that determine the functionality of TFBSs by focusing on the molecular biological mechanisms and evolutionary origins of cis-regulatory regions. PMID:19721087

  14. 7 CFR 868.304 - Broken kernels determination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Broken kernels determination. 868.304 Section 868.304 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... Application of Standards § 868.304 Broken kernels determination. Broken kernels shall be determined by the use...

  15. 7 CFR 868.304 - Broken kernels determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Broken kernels determination. 868.304 Section 868.304 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... Application of Standards § 868.304 Broken kernels determination. Broken kernels shall be determined by the use...

  16. 48 CFR 22.404-11 - Wage determination appeals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Wage determination appeals... Involving Construction 22.404-11 Wage determination appeals. The Secretary of Labor has established an... Davis-Bacon Act wage determinations. A contracting agency or other interested party may file a petition...

  17. Determination of plant growth regulators in pears by microwave-assisted extraction and liquid chromatography with electrospray ionization mass spectrometry.

    PubMed

    Mao, Xuejin; Tang, Lijuan; Tan, Ting; Wan, Yiqun

    2014-06-01

    A new method for the determination of six plant growth regulators, 3-indolylacetic acid, 3-indolepropionic acid, 2-naphthoxyacetic acid, 2,4-dicholrophenoxyacetic acid, 1-naphthlcetic acid, and methyl naphthalene-1-acetate, in pears was established by liquid chromatography with electrospray ionization mass spectrometry. In this study, a microwave-assisted extraction technique was first applied for the determination of plant growth regulators in fruit and three cleanup techniques were, respectively, investigated for the purification of pear samples. The chromatographic separation was performed on a Diamonsil C18 column by using 0.01 mol/L formic acid/ammonium formate buffer solution (pH 3.5)/methanol (35:65, v/v) as the mobile phase with a flow rate of 0.7 mL/min in 1:1 split mode. The LODs ranged from 0.3 to 1.9 μg/kg. Under optimized conditions, the average recoveries (five replicates) for six plant growth regulators (spiked at 0.01, 0.05, and 0.5 mg/kg) ranged from 78.9 to 118.0%, and the RSDs were 1.4-10.3%. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. The benefits of being self-determined in promoting physical activity and affective well-being among women recently treated for breast cancer.

    PubMed

    Brunet, Jennifer; Burke, Shaunna M; Sabiston, Catherine M

    2013-10-01

    In this study, changes in motivational regulations in women following treatment for breast cancer were described. Changes in motivational regulations as predictors of subsequent change in light and moderate-to-vigorous physical activity (PA) and affect were also examined. Women [n = 150; M(age) = 54.41 (SD = 10.87) years] completed self-report questionnaires and wore an accelerometer for 7 days at Time 1 [M = 3.94 (SD = 3.08) months following primary treatment], as well as 3 (Time 2) and 6 (Time 3) months later. Data were analyzed using repeated-measures analysis of variance and path analysis using residual change scores. Identified regulation and self-determined motivation (i.e., combined intrinsic motivation and identified regulation) scores decreased over time (p < 0.05). In the path model [χ(2)(4) = 5.66, p = 0.22, root mean square error of approximation = 0.05 (90% CI: 0.0; 0.15), comparative fit index = 0.99, standardized root mean square of the residuals = 0.03], ΔTime(1-2) in external regulation was associated with ΔTime(2-3) in positive affect (β = -0.16), ΔTime(1-2) in introjected (β = 0.25) and amotivation (β = 0.19) were related to ΔTime(2-3) in negative affect, and ΔTime(1-2) in self-determined motivation was related to ΔTime(2-3) in positive affect (β = 0.40) and moderate-to-vigorous PA (β = 0.21). Changes in motivational regulations were related to changes in PA and affect in the aftermath of breast cancer. Given the benefits of self-determined motivation, additional research is needed to develop and test interventions aimed at enhancing this type of motivation. Copyright © 2013 John Wiley & Sons, Ltd.

  19. 29 CFR 531.4 - Making determinations of “reasonable cost.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS WAGE PAYMENTS UNDER THE FAIR LABOR STANDARDS ACT OF 1938 Determinations of âReasonable Costâ and âFair Valueâ; Effects of Collective Bargaining Agreements § 531.4 Making determinations of “reasonable...

  20. 27 CFR 70.222 - Time return deemed filed for purposes of determining limitations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... return deemed filed for purposes of determining limitations. (a) Early Return. Any return filed prior to the last day prescribed by law or regulations for the filing thereof (determined without regard to any...

  1. 27 CFR 70.222 - Time return deemed filed for purposes of determining limitations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... return deemed filed for purposes of determining limitations. (a) Early Return. Any return filed prior to the last day prescribed by law or regulations for the filing thereof (determined without regard to any...

  2. 27 CFR 70.222 - Time return deemed filed for purposes of determining limitations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... return deemed filed for purposes of determining limitations. (a) Early Return. Any return filed prior to the last day prescribed by law or regulations for the filing thereof (determined without regard to any...

  3. 27 CFR 70.222 - Time return deemed filed for purposes of determining limitations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... return deemed filed for purposes of determining limitations. (a) Early Return. Any return filed prior to the last day prescribed by law or regulations for the filing thereof (determined without regard to any...

  4. 27 CFR 70.222 - Time return deemed filed for purposes of determining limitations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... return deemed filed for purposes of determining limitations. (a) Early Return. Any return filed prior to the last day prescribed by law or regulations for the filing thereof (determined without regard to any...

  5. Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth.

    PubMed

    Kim, Eun-Kyung; Cho, Jae Hee; Kim, EuiJoo; Kim, Yoon Jae

    2017-01-01

    The regulation of reactive oxygen species (ROS) exists as a therapeutic target for cancer treatments. Previous studies have shown that ursodeoxycholic acid (UDCA) suppresses the proliferation of colon cancer cells. The aim of this study was to evaluate the effect of UDCA upon the proliferation of colon cancer cells as a direct result of the regulation of ROS. Colon cancer cell lines (HT29 and HCT116) were treated with UDCA. The total number of cells and the number of dead cells were determined using cell counters. A fluorescein isothiocyanate-bromodeoxyuridine flow kit was used to analyze cell cycle variations. Upon exposure to UDCA, the protein levels of p27, p21, CDK2, CDK4 and CDK6 were determined using western blotting, and qRT-PCR was used to determine levels of mRNA. We preformed dichlorofluorescindiacetate (DCF-DA) staining to detect alteration of intracellular ROS using fluorescence activated cell sorting (FACS). Colon cancer stem-like cell lines were generated by tumorsphere culture and treated with UDCA for seven days. The total number of tumorspheres was determined using microscopy. We found that UDCA reduced the total number of colon cancer cells, but did not increase the number of dead cells. UDCA inhibited the G1/S and G2/M transition phases in colon cancer cells. UDCA induced expression of cell cycle inhibitors such as p27 and p21. However, it was determined that UDCA suppressed levels of CDK2, CDK4, and CDK6. UDCA regulated intracellular ROS generation in colon cancer cells, and induced activation of Erk1/2. Finally, UDCA inhibited formation of colon cancer stem-like cells. Our results indicate that UDCA suppresses proliferation through regulation of oxidative stress in colon cancer cells, as well as colon cancer stem-like cells.

  6. Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth

    PubMed Central

    Kim, EuiJoo

    2017-01-01

    Introduction The regulation of reactive oxygen species (ROS) exists as a therapeutic target for cancer treatments. Previous studies have shown that ursodeoxycholic acid (UDCA) suppresses the proliferation of colon cancer cells. The aim of this study was to evaluate the effect of UDCA upon the proliferation of colon cancer cells as a direct result of the regulation of ROS. Method Colon cancer cell lines (HT29 and HCT116) were treated with UDCA. The total number of cells and the number of dead cells were determined using cell counters. A fluorescein isothiocyanate-bromodeoxyuridine flow kit was used to analyze cell cycle variations. Upon exposure to UDCA, the protein levels of p27, p21, CDK2, CDK4 and CDK6 were determined using western blotting, and qRT-PCR was used to determine levels of mRNA. We preformed dichlorofluorescindiacetate (DCF-DA) staining to detect alteration of intracellular ROS using fluorescence activated cell sorting (FACS). Colon cancer stem-like cell lines were generated by tumorsphere culture and treated with UDCA for seven days. The total number of tumorspheres was determined using microscopy. Results We found that UDCA reduced the total number of colon cancer cells, but did not increase the number of dead cells. UDCA inhibited the G1/S and G2/M transition phases in colon cancer cells. UDCA induced expression of cell cycle inhibitors such as p27 and p21. However, it was determined that UDCA suppressed levels of CDK2, CDK4, and CDK6. UDCA regulated intracellular ROS generation in colon cancer cells, and induced activation of Erk1/2. Finally, UDCA inhibited formation of colon cancer stem-like cells. Conclusion Our results indicate that UDCA suppresses proliferation through regulation of oxidative stress in colon cancer cells, as well as colon cancer stem-like cells. PMID:28708871

  7. 7 CFR 51.1416 - Optional determinations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1 2...

  8. 7 CFR 51.1416 - Optional determinations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2...

  9. RMP Guidance for Chemical Distributors - Table of Contents

    EPA Pesticide Factsheets

    Risk Management Program guidance helps owners and operators of stationary sources to determine if their processes are subject to regulation under section 112(r) of the Clean Air Act and 40 CFR part 68 and to comply with regulations.

  10. 48 CFR 1419.602 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Procedures. 1419.602 Section 1419.602 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility 1419.602...

  11. 48 CFR 819.602 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Procedures. 819.602 Section 819.602 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility 819.602...

  12. 48 CFR 619.602 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Procedures. 619.602 Section 619.602 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Eligibility 619.602 Procedures. ...

  13. 48 CFR 2819.602 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Procedures. 2819.602 Section 2819.602 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Socioeconomic Programs SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Eligibility 2819.602 Procedures. ...

  14. 29 CFR (non-Mandatory) Appendix B... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Part 1926-Criteria for Determining the Feasibility of Providing Safe Access and Fall Protection for Scaffold Erectors and Dismantlers Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR...

  15. 29 CFR (non-Mandatory) Appendix B... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Part 1926-Criteria for Determining the Feasibility of Providing Safe Access and Fall Protection for Scaffold Erectors and Dismantlers Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR...

  16. 36 CFR 223.116 - Cancellation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL PRODUCTS Timber... judicial determination, of violation of civil standards, orders, permits, or others regulations for the... such laws or regulations would preclude performance of other contractual requirements. (5) Upon...

  17. 7 CFR 800.195 - Delegations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... grain do not exceed, as determined by the Administrator, 5 per centum of the total amount of grain... Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Delegations...

  18. 7 CFR 800.195 - Delegations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... grain do not exceed, as determined by the Administrator, 5 per centum of the total amount of grain... Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Delegations...

  19. 7 CFR 800.195 - Delegations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... grain do not exceed, as determined by the Administrator, 5 per centum of the total amount of grain... Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Delegations...

  20. 7 CFR 61.101 - Determination of grade.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COTTONSEED SOLD OR OFFERED...

  1. 7 CFR 987.35 - Modifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Marketing Policy § 987.35 Modifications. In the event the Committee subsequently determines that the marketing policy should be modified due to changing...

  2. Consumer and Commercial Products, Group IV: Control Techniques Guidelines in Lieu of Regulations

    EPA Pesticide Factsheets

    EPA has determined that control techniques guidelines (CTGs) will be substantially as effective as regulations in reducing volatile organic compound (VOC) emissions in ozone nonattainment areas for certain consumer and commercial product categories.

  3. 48 CFR 22.404-4 - Solicitations issued without wage determinations for the primary site of the work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS... issued as an amendment to the solicitation. (b) In sealed bidding, bids may not be opened until a...

  4. 48 CFR 3009.171-8 - Ineligible contractors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Ineligible contractors..., HOMELAND SECURITY ACQUISITION REGULATION (HSAR) ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Responsible Prospective Contractors 3009.171-8 Ineligible contractors. Any business concern determined to be ineligible...

  5. 42 CFR 57.2002 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., dentistry, or other health profession, as determined under regulations prescribed by the Secretary of... institution, leading to a degree in medicine, dentistry, or other health profession, as determined under...

  6. 42 CFR 57.2002 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., dentistry, or other health profession, as determined under regulations prescribed by the Secretary of... institution, leading to a degree in medicine, dentistry, or other health profession, as determined under...

  7. 14 CFR 272.5 - Determination of essential air service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS ESSENTIAL AIR SERVICE TO THE FREELY ASSOCIATED STATES § 272.5 Determination of essential air service. Procedures for the determination of essential air service under this... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Determination of essential air service. 272...

  8. 32 CFR 1901.43 - Determination(s) by Deputy Director(s).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Determination(s) by Deputy Director(s). 1901.43 Section 1901.43 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE..., first-out” basis taking into account the business requirements of the parties and consistent with the...

  9. 48 CFR 22.1012-1 - Prevailing wage determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Prevailing wage... wage determination in a solicitation, contract or contract modification (see 22.1007) is determined by... wage determination shall not be effective if it is received by the contracting agency less than 10 days...

  10. 40 CFR 68.115 - Threshold determination.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Threshold determination. 68.115... § 68.115 Threshold determination. (a) A threshold quantity of a regulated substance listed in § 68.130... process exceeds the threshold. (b) For the purposes of determining whether more than a threshold quantity...

  11. The expression of genes involved in myometrial contractility changes during ex situ culture of pregnant human uterine smooth muscle tissue.

    PubMed

    Ilicic, Marina; Butler, Trent; Zakar, Tamas; Paul, Jonathan W

    2017-01-01

    Ex situ analyses of human myometrial tissue has been used to investigate the regulation of uterine quiescence and transition to a contractile phenotype. Following concerns about the validity of cultured primary cells, we examined whether myometrial tissue undergoes culture-induced changes ex situ that may affect the validity of in vitro models. To determine whether human myometrial tissue undergoes culture-induced changes ex situ in Estrogen receptor 1 (ESR1), Prostaglandin-endoperoxide synthase 2 (PTGS2) and Oxytocin receptor (OXTR) expression. Additionally, to determine whether culture conditions approaching the in vivo environment influence the expression of these key genes. Term non-laboring human myometrial tissues were cultured in the presence of specific treatments, including; serum supplementation, progesterone and estrogen, cAMP, PMA, stretch or NF-κB inhibitors. ESR1, PTGS2 and OXTR mRNA abundance after 48 h culture was determined using quantitative RT-PCR. Myometrial tissue in culture exhibited culture-induced up-regulation of ESR1 and PTGS2 and down-regulation of OXTR mRNA expression. Progesterone prevented culture-induced increase in ESR1 expression. Estrogen further up-regulated PTGS2 expression. Stretch had no direct effect, but blocked the effects of progesterone and estrogen on ESR1 and PTGS2 expression. cAMP had no effect whereas PMA further up-regulated PTGS2 expression and prevented decline of OXTR expression. Human myometrial tissue in culture undergoes culture-induced gene expression changes consistent with transition toward a laboring phenotype. Changes in ESR1, PTGS2 and OXTR expression could not be controlled simultaneously. Until optimal culture conditions are determined, results of in vitro experiments with myometrial tissues should be interpreted with caution.

  12. Tribolium castaneum Transformer-2 regulates sex determination and development in both males and females.

    PubMed

    Shukla, Jayendra Nath; Palli, Subba Reddy

    2013-12-01

    Tribolium castaneum Transformer (TcTra) is essential for female sex determination and maintenance through the regulation of sex-specific splicing of doublesex (dsx) pre-mRNA. In females, TcTra also regulates the sex-specific splicing of its own pre-mRNA to ensure continuous production of functional Tra protein. Transformer protein is absent in males and hence dsx pre-mRNA is spliced in a default mode. The mechanisms by which males inhibit the production of functional Tra protein are not known. Here, we report on functional characterization of transformer-2 (tra-2) gene (an ortholog of Drosophila transformer-2) in T. castaneum. RNA interference-mediated knockdown in the expression of gene coding for tra-2 in female pupae or adults resulted in the production of male-specific isoform of dsx and both female and male isoforms of tra suggesting that Tra-2 is essential for the female-specific splicing of tra and dsx pre-mRNAs. Interestingly, knockdown of tra-2 in males did not affect the splicing of dsx but resulted in the production of both female and male isoforms of tra suggesting that Tra-2 suppresses female-specific splicing of tra pre-mRNA in males. This dual regulation of sex-specific splicing of tra pre-mRNA ensures a tight regulation of sex determination and maintenance. These data suggest a critical role for Tra-2 in suppression of female sex determination cascade in males. In addition, RNAi studies showed that Tra-2 is also required for successful embryonic and larval development in both sexes. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. In-phase oscillation of global regulons is orchestrated by a pole-specific organizer

    PubMed Central

    Janakiraman, Balaganesh; Mignolet, Johann; Narayanan, Sharath; Viollier, Patrick H.

    2016-01-01

    Cell fate determination in the asymmetric bacterium Caulobacter crescentus (Caulobacter) is triggered by the localization of the developmental regulator SpmX to the old (stalked) cell pole during the G1→S transition. Although SpmX is required to localize and activate the cell fate-determining kinase DivJ at the stalked pole in Caulobacter, in cousins such as Asticcacaulis, SpmX directs organelle (stalk) positioning and possibly other functions. We define the conserved σ54-dependent transcriptional activator TacA as a global regulator in Caulobacter whose activation by phosphorylation is indirectly down-regulated by SpmX. Using a combination of forward genetics and cytological screening, we uncover a previously uncharacterized and polarized component (SpmY) of the TacA phosphorylation control system, and we show that SpmY function and localization are conserved. Thus, SpmX organizes a site-specific, ancestral, and multifunctional regulatory hub integrating the in-phase oscillation of two global transcriptional regulators, CtrA (the master cell cycle transcriptional regulator A) and TacA, that perform important cell cycle functions. PMID:27791133

  14. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    PubMed

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  15. 48 CFR 42.705-2 - Auditor determination procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Auditor determination... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.705-2 Auditor determination procedure. (a) Applicability and responsibility. (1) The cognizant Government auditor shall...

  16. 5 CFR 575.108 - Approval criteria and written determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS RECRUITMENT, RELOCATION, AND RETENTION INCENTIVES; SUPERVISORY DIFFERENTIALS; AND EXTENDED ASSIGNMENT INCENTIVES Recruitment Incentives § 575.108 Approval criteria and written determination. (a) For each determination to pay a recruitment incentive under this subpart, an agency must document in...

  17. 48 CFR 42.705-2 - Auditor determination procedure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Auditor determination... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.705-2 Auditor determination procedure. (a) Applicability and responsibility. (1) The cognizant Government auditor shall...

  18. Regulation of Neuronal Muscarinic Acetylcholine Receptors

    DTIC Science & Technology

    1989-01-01

    N1E - 115 cells with pertussis toxin blocks mAChR-mediated inhibition of adenylate cyclase but not mAChR-mediated stimulation of PI turnover...determine the effects of electrical depolarization on muscarinic acetylcholine receptors (mAChR) in the cultured neuroblastoma cell line, N E- 115 ...evidence that Gi and Go may differentially regulate cellular signaling mechanisms, these results suggest that depolarization may regulate specific

  19. Know Thy Student! Combining Learning Analytics and Critical Reflections to Increase Understanding of Students' Self-Regulated Learning in an Authentic Setting

    ERIC Educational Resources Information Center

    Colthorpe, Kay; Zimbardi, Kirsten; Ainscough, Louise; Anderson, Stephen

    2015-01-01

    It is well established that a student's capacity to regulate his or her own learning is a key determinant of academic success, suggesting that interventions targeting improvements in self-regulation will have a positive impact on academic performance. However, to evaluate the success of such interventions, the self-regulatory characteristics of…

  20. 77 FR 30335 - Proposed Revision 3 to Standard Review Plan, Section 19.1 on Determining the Technical Adequacy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ...). The Office of New Reactors and Office of Nuclear Reactor Regulation are revising SRP Section 19.1... of the Code of Federal Regulations (10 CFR), 50.71(h)(1), (h)(2), and (h)(3) for new reactors, (2... searching on http://www.regulations.gov under Docket ID NRC-2012-0113. You may submit comments by the...

  1. Army Reserve Capabilities-Based Prioritization Study

    DTIC Science & Technology

    2008-08-15

    regulations and procedural guidance are not sufficient to determine the ‘ground truth’ of Planning, Programming, Budgeting and Execution System (PPBES...list), Department of the Army (DA) and Army Reserve Regulations and DA pamphlets. A-3 c. Why this Study Has Not Yet Been Performed/Funded...Memorandum, Management Decision Packages, 1-N list), Department of the Army (DA) and Army Reserve Regulations and DA pamphlets. b. Initial Assessment

  2. 7 CFR 51.2341 - Sample size for grade determination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 51.2341 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT FRESH FRUITS, VEGETABLES AND OTHER...

  3. 7 CFR 51.2341 - Sample size for grade determination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 51.2341 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION...

  4. 32 CFR 1901.61 - Purpose and authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and security suitability investigations (or promotion material in the case of the armed services... National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... Central Intelligence has determined to exempt from the procedures established by this regulation and from...

  5. 7 CFR 27.34 - Classification procedure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Classification procedure. 27.34 Section 27.34... REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification and Micronaire Determinations § 27.34 Classification procedure. Classification shall proceed as rapidly as possible, but not...

  6. 7 CFR 27.34 - Classification procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Classification procedure. 27.34 Section 27.34... REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification and Micronaire Determinations § 27.34 Classification procedure. Classification shall proceed as rapidly as possible, but not...

  7. 7 CFR 27.34 - Classification procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Classification procedure. 27.34 Section 27.34... REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification and Micronaire Determinations § 27.34 Classification procedure. Classification shall proceed as rapidly as possible, but not...

  8. 48 CFR 25.405 - Caribbean Basin Trade Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Initiative. 25.405 Section 25.405 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Trade Agreements 25.405 Caribbean Basin Trade Initiative. Under the Caribbean Basin Trade Initiative, the United States Trade Representative has determined that, for...

  9. 7 CFR 61.102 - Determination of quantity index.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COTTONSEED SOLD OR OFFERED...

  10. 48 CFR 419.602-1 - Referral.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Referral. 419.602-1 Section 419.602-1 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility 419.602-1...

  11. 48 CFR 1319.602-1 - Referral.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Referral. 1319.602-1 Section 1319.602-1 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determination of Responsibility 1319.602-1...

  12. 48 CFR 837.103 - Contracting officer responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting officer responsibility. 837.103 Section 837.103 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... officer responsibility. When the contracting officer determines that legal assistance is necessary in...

  13. 48 CFR 1326.203 - Transition of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Transition of work. 1326.203 Section 1326.203 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC... work. The designee authorized to determine that transitioning response, relief, and/or reconstruction...

  14. 48 CFR 17.206 - Evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contracting officer. An example of a circumstance that may support a determination not to evaluate offers for... 17.206 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.206 Evaluation. (a) In awarding the basic contract...

  15. 7 CFR 27.34 - Classification procedure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Classification procedure. 27.34 Section 27.34... REGULATIONS COTTON CLASSIFICATION UNDER COTTON FUTURES LEGISLATION Regulations Classification and Micronaire Determinations § 27.34 Classification procedure. Classification shall proceed as rapidly as possible, but not...

  16. TECHNOLOGY TRANSFER ENVIRONMENTAL REGULATIONS AND TECHNOLOGY : CONTROL OF PATHOGENS IN MUNICIPAL WASTEWATER SLUDGE

    EPA Science Inventory

    This 71 - page Technology Transfer Environmental Regulations and echnology publication describes the Federal requirements promulgated in 1979 for reducing pathogens n wastewater sludge and provides guidance in determining whether individual sludge treatment andated or particular ...

  17. 41 CFR 102-38.265 - Must we keep records on administrative determinations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 38-SALE OF PERSONAL PROPERTY Bids Mistakes in Bids § 102-38.265 Must we keep records on administrative... you file with the Comptroller General when requested. ...

  18. 41 CFR 102-38.265 - Must we keep records on administrative determinations?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 38-SALE OF PERSONAL PROPERTY Bids Mistakes in Bids § 102-38.265 Must we keep records on administrative... you file with the Comptroller General when requested. ...

  19. 48 CFR 825.103 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... article is likely to affect future acquisitions, include a recommendation that a copy of the determination... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exceptions. 825.103 Section 825.103 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC...

  20. What determines organ size differences between species? A meta-analysis of the cellular basis.

    PubMed

    Gázquez, Ayelén; Beemster, Gerrit T S

    2017-07-01

    Little is known about how the characteristic differences in organ size between species are regulated. At the cellular level, the size of an organ is strictly regulated by cell division and expansion during its development. We performed a meta-analysis of the growth parameters of roots, and Graminae and eudicotyledonous leaves, to address the question of how quantitative variation in these two processes contributes to size differences across a range of species. We extracted or derived cellular parameters from published kinematic growth analyses. These data were subjected to linear regression analyses to identify the parameters that determine differences in organ growth. Our results demonstrate that, across all species and organs, similar conclusions can be made: cell number rather than cell size determines the final size of plant organs; cell number is determined by meristem size rather than the rate at which cells divide; cells that are small when leaving the meristem compensate by expanding for longer; mature cell size is primarily determined by the duration of cell expansion. These results identify the regulation of the transition from cell division to expansion as the key cellular mechanism targeted by the evolution of organ size. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  1. Transcriptional Regulatory Networks in Saccharomyces cerevisiae

    NASA Astrophysics Data System (ADS)

    Lee, Tong Ihn; Rinaldi, Nicola J.; Robert, François; Odom, Duncan T.; Bar-Joseph, Ziv; Gerber, Georg K.; Hannett, Nancy M.; Harbison, Christopher T.; Thompson, Craig M.; Simon, Itamar; Zeitlinger, Julia; Jennings, Ezra G.; Murray, Heather L.; Gordon, D. Benjamin; Ren, Bing; Wyrick, John J.; Tagne, Jean-Bosco; Volkert, Thomas L.; Fraenkel, Ernest; Gifford, David K.; Young, Richard A.

    2002-10-01

    We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.

  2. Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deborah L. Layton; Kimberly Frerichs

    2011-12-01

    The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and themore » results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).« less

  3. Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deborah L. Layton; Kimberly Frerichs

    2010-07-01

    The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and themore » results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).« less

  4. 29 CFR 1956.63 - Determination of operational effectiveness. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Determination of operational effectiveness. [Reserved] 1956.63 Section 1956.63 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... PLANS New Jersey § 1956.63 Determination of operational effectiveness. [Reserved] ...

  5. 29 CFR 1956.73 - Determination of operational effectiveness. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Determination of operational effectiveness. [Reserved] 1956.73 Section 1956.73 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... PLANS The Virgin Islands § 1956.73 Determination of operational effectiveness. [Reserved] ...

  6. 24 CFR 598.105 - Data used for eligibility determinations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... determinations. 598.105 Section 598.105 Housing and Urban Development Regulations Relating to Housing and Urban... DESIGNATIONS Eligibility Requirements § 598.105 Data used for eligibility determinations. (a) Source of data... the boundaries of census tracts, as defined in § 598.3. ...

  7. 24 CFR 598.105 - Data used for eligibility determinations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... determinations. 598.105 Section 598.105 Housing and Urban Development Regulations Relating to Housing and Urban... DESIGNATIONS Eligibility Requirements § 598.105 Data used for eligibility determinations. (a) Source of data... the boundaries of census tracts, as defined in § 598.3. ...

  8. 24 CFR 598.420 - Periodic progress determinations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Periodic progress determinations. 598.420 Section 598.420 Housing and Urban Development Regulations Relating to Housing and Urban... DESIGNATIONS Post-Designation Requirements § 598.420 Periodic progress determinations. HUD will regularly...

  9. 24 CFR 598.420 - Periodic progress determinations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Periodic progress determinations. 598.420 Section 598.420 Housing and Urban Development Regulations Relating to Housing and Urban... DESIGNATIONS Post-Designation Requirements § 598.420 Periodic progress determinations. HUD will regularly...

  10. 24 CFR 598.420 - Periodic progress determinations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Periodic progress determinations. 598.420 Section 598.420 Housing and Urban Development Regulations Relating to Housing and Urban... DESIGNATIONS Post-Designation Requirements § 598.420 Periodic progress determinations. HUD will regularly...

  11. 24 CFR 598.105 - Data used for eligibility determinations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... determinations. 598.105 Section 598.105 Housing and Urban Development Regulations Relating to Housing and Urban... DESIGNATIONS Eligibility Requirements § 598.105 Data used for eligibility determinations. (a) Source of data... the boundaries of census tracts, as defined in § 598.3. ...

  12. 76 FR 16735 - Federal Acquisition Regulation; Information Collection; Certification of Independent Price...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ...; Information Collection; Certification of Independent Price Determination and Parent Company and Identifying... requirement concerning certification of independent price determination and parent company and identifying.... Please cite OMB Control No. 9000-0018, Certification of Independent Price Determination and Parent...

  13. 76 FR 37353 - Federal Acquisition Regulation; Information Collection; Certification of Independent Price...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ...; Information Collection; Certification of Independent Price Determination and Parent Company and Identifying... requirement concerning certification of independent price determination and parent company and identifying.... Please cite OMB Control No. 9000-0018, Certification of Independent Price Determination and Parent...

  14. 5 CFR 351.401 - Determining retention standing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Determining retention standing. 351.401 Section 351.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Scope of Competition § 351.401 Determining retention standing. Each agency shall...

  15. 5 CFR 351.401 - Determining retention standing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Determining retention standing. 351.401 Section 351.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Scope of Competition § 351.401 Determining retention standing. Each agency shall...

  16. 5 CFR 351.401 - Determining retention standing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Determining retention standing. 351.401 Section 351.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Scope of Competition § 351.401 Determining retention standing. Each agency shall...

  17. 5 CFR 351.401 - Determining retention standing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Determining retention standing. 351.401 Section 351.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Scope of Competition § 351.401 Determining retention standing. Each agency shall...

  18. 5 CFR 351.401 - Determining retention standing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Determining retention standing. 351.401 Section 351.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Scope of Competition § 351.401 Determining retention standing. Each agency shall...

  19. Self-determination, behavioral engagement, disaffection, and academic performance: a mediational analysis.

    PubMed

    González, Antonio; Paoloni, Paola Verónica

    2014-11-14

    The present study examined the role of behavioral engagement and disaffection as mediators between self-determination and academic performance. Participants were 545 secondary students (53.4% girls) aged 12 to 19 years. Variables were assessed in the Spanish language classroom over a nine-month period. Students estimated their self-determination, and their teachers assessed student engagement, disaffection, and performance. Structural equation models corroborated the hypotheses: the types of self-determination differentially predicted engagement (R 2 = .39) and disaffection (R 2 = .24), and were progressively more adaptive the higher the autonomy; self-determination, behavioral engagement, and disaffection predicted performance (R 2 = .43); engagement and disaffection partially mediated the relationship from external regulation (β = -.097; p < .002; Confidence Interval = -.177, -.051), identified regulation (β = .109; p < .006; CI = .054, .165), and intrinsic motivation (β = .139; p < .002; CI = .086, .206) to performance. The implications of these findings for current theory and educational intervention are discussed.

  20. Drosophila Hox and Sex-Determination Genes Control Segment Elimination through EGFR and extramacrochetae Activity

    PubMed Central

    Foronda, David; Martín, Paloma; Sánchez-Herrero, Ernesto

    2012-01-01

    The formation or suppression of particular structures is a major change occurring in development and evolution. One example of such change is the absence of the seventh abdominal segment (A7) in Drosophila males. We show here that there is a down-regulation of EGFR activity and fewer histoblasts in the male A7 in early pupae. If this activity is elevated, cell number increases and a small segment develops in the adult. At later pupal stages, the remaining precursors of the A7 are extruded under the epithelium. This extrusion requires the up-regulation of the HLH protein Extramacrochetae and correlates with high levels of spaghetti-squash, the gene encoding the regulatory light chain of the non-muscle myosin II. The Hox gene Abdominal-B controls both the down-regulation of spitz, a ligand of the EGFR pathway, and the up-regulation of extramacrochetae, and also regulates the transcription of the sex-determining gene doublesex. The male Doublesex protein, in turn, controls extramacrochetae and spaghetti-squash expression. In females, the EGFR pathway is also down-regulated in the A7 but extramacrochetae and spaghetti-squash are not up-regulated and extrusion of precursor cells is almost absent. Our results show the complex orchestration of cellular and genetic events that lead to this important sexually dimorphic character change. PMID:22912593

  1. 7 CFR 52.3758 - Determining the grade of a sample unit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 52.3758 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS THEREOF, AND CERTAIN...

  2. 7 CFR 2201.33 - Defaults.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Defaults. 2201.33 Section 2201.33 Agriculture Regulations of the Department of Agriculture (Continued) LOCAL TELEVISION LOAN GUARANTEE BOARD LOCAL TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS Loan Guarantees § 2201.33 Defaults. (a) In determining...

  3. 48 CFR 2803.906 - Remedies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Remedies. 2803.906 Section 2803.906 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE GENERAL IMPROPER BUSINESS... Remedies. (a) Upon determination that a contractor has subjected one of its employees to a reprisal for...

  4. 48 CFR 2803.906 - Remedies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Remedies. 2803.906 Section 2803.906 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General IMPROPER BUSINESS... Remedies. (a) Upon determination that a contractor has subjected one of its employees to a reprisal for...

  5. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2017-10-01

    ... 48 Federal Acquisition Regulations System 7 2017-10-01 2017-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY....704 Content. The following format shall be used for all determinations and findings (D&Fs), unless...

  6. 48 CFR 3001.704 - Content.

    Code of Federal Regulations, 2010 CFR

    2005-10-01

    ... 48 Federal Acquisition Regulations System 7 2005-10-01 2005-10-01 false Content. 3001.704 Section 3001.704 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY....704 Content. The following format shall be used for all determinations and findings (D&Fs), unless...

  7. 32 CFR 1901.61 - Purpose and authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... Central Intelligence has determined to exempt from the procedures established by this regulation and from... intelligence and related organizations and thus reveal or jeopardize intelligence sources and methods or risk...

  8. 32 CFR 1901.61 - Purpose and authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS... Central Intelligence has determined to exempt from the procedures established by this regulation and from... intelligence and related organizations and thus reveal or jeopardize intelligence sources and methods or risk...

  9. 48 CFR 1419.602-1 - Referral.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Referral. 1419.602-1 Section 1419.602-1 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Responsibility 1419.602-1...

  10. 48 CFR 619.602-1 - Referral.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Referral. 619.602-1 Section 619.602-1 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Eligibility 619.602-1 Referral. The...

  11. 48 CFR 2819.602-1 - Referral.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Referral. 2819.602-1 Section 2819.602-1 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Socioeconomic Programs SMALL BUSINESS PROGRAMS Certificates of Competency and Determinations of Eligibility 2819.602-1 Referral...

  12. 48 CFR 2425.402 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2425.402 Section 2425.402 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS TRADE AGREEMENTS ACT 2425.402 Policy. (a)(1) It is the Department's policy to determine...

  13. 48 CFR 1609.7101 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 1609.7101 Section 1609.7101 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Evaluation 1609.7101 Policy. At the end of each contract period, the contracting officer will determine each...

  14. 48 CFR 2425.402 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 2425.402 Section 2425.402 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS TRADE AGREEMENTS ACT 2425.402 Policy. (a)(1) It is the Department's policy to determine...

  15. 48 CFR 1609.7101 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 1609.7101 Section 1609.7101 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Evaluation 1609.7101 Policy. At the end of each contract period, the contracting officer will determine each...

  16. 48 CFR 2425.402 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 2425.402 Section 2425.402 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS TRADE AGREEMENTS ACT 2425.402 Policy. (a)(1) It is the Department's policy to determine...

  17. 48 CFR 1609.7101 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 1609.7101 Section 1609.7101 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Evaluation 1609.7101 Policy. At the end of each contract period, the contracting officer will determine each...

  18. 48 CFR 1028.106-6 - Furnishing information.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Furnishing information. 1028.106-6 Section 1028.106-6 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY GENERAL... certified copies and determine reasonable and appropriate costs, after consultation with legal counsel. ...

  19. 40 CFR 52.2633 - Stack height regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Stack height regulations. 52.2633 Section 52.2633 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... with the “Guideline for Determination of Good Engineering Practice Stack Height (Technical Support...

  20. 32 CFR 2400.9 - Classification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....9 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY... unauthorized disclosure as determined by the Director, Office of Science and Technology Policy. Each such...

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