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Sample records for regulating rods

  1. NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors.

    PubMed

    Kim, Jung-Woong; Yang, Hyun-Jin; Brooks, Matthew John; Zelinger, Lina; Karakülah, Gökhan; Gotoh, Norimoto; Boleda, Alexis; Gieser, Linn; Giuste, Felipe; Whitaker, Dustin Thad; Walton, Ashley; Villasmil, Rafael; Barb, Jennifer Joanna; Munson, Peter Jonathan; Kaya, Koray Dogan; Chaitankar, Vijender; Cogliati, Tiziana; Swaroop, Anand

    2016-11-22

    Gene regulatory networks (GRNs) guiding differentiation of cell types and cell assemblies in the nervous system are poorly understood because of inherent complexities and interdependence of signaling pathways. Here, we report transcriptome dynamics of differentiating rod photoreceptors in the mammalian retina. Given that the transcription factor NRL determines rod cell fate, we performed expression profiling of developing NRL-positive (rods) and NRL-negative (S-cone-like) mouse photoreceptors. We identified a large-scale, sharp transition in the transcriptome landscape between postnatal days 6 and 10 concordant with rod morphogenesis. Rod-specific temporal DNA methylation corroborated gene expression patterns. De novo assembly and alternative splicing analyses revealed previously unannotated rod-enriched transcripts and the role of NRL in transcript maturation. Furthermore, we defined the relationship of NRL with other transcriptional regulators and downstream cognate effectors. Our studies provide the framework for comprehensive system-level analysis of the GRN underlying the development of a single sensory neuron, the rod photoreceptor. Published by Elsevier Inc.

  2. Developmental regulation of calcium-dependent feedback in Xenopus rods

    PubMed Central

    Solessio, Eduardo; Mani, Shobana S.; Cuenca, Nicolas; Engbretson, Gustav A.; Barlow, Robert B.; Knox, Barry E.

    2004-01-01

    The kinetics of activation and inactivation in the phototransduction pathway of developing Xenopus rods were studied. The gain of the activation steps in transduction (amplification) increased and photoresponses became more rapid as the rods matured from the larval to the adult stage. The time to peak was significantly shorter in adults (1.3 s) than tadpoles (2 s). Moreover, adult rods recovered twice as fast from saturating flashes than did larval rods without changes of the dominant time constant (2.5 s). Guanylate cyclase (GC) activity, determined using IBMX steps, increased in adult rods from ∼1.1 s−1 to 3.7 s−1 5 s after a saturating flash delivering 6,000 photoisomerizations. In larval rods, it increased from 1.8 s−1 to 4.0 s−1 9 s after an equivalent flash. However, the ratio of amplification to the measured dark phosphodiesterase activity was constant. Guanylate cyclase–activating protein (GCAP1) levels and normalized Na+/Ca2+, K+ exchanger currents were increased in adults compared with tadpoles. Together, these results are consistent with the acceleration of the recovery phase in adult rods via developmental regulation of calcium homeostasis. Despite these large changes, the single photon response amplitude was ∼0.6 pA throughout development. Reduction of calcium feedback with BAPTA increased adult single photon response amplitudes threefold and reduced its cutoff frequency to that observed with tadpole rods. Linear mathematical modeling suggests that calcium-dependent feedback can account for the observed differences in the power spectra of larval and adult rods. We conclude that larval Xenopus maximize sensitivity at the expense of slower response kinetics while adults maximize response kinetics at the expense of sensitivity. PMID:15504902

  3. Circadian and light-driven regulation of rod dark adaptation.

    PubMed

    Xue, Yunlu; Shen, Susan Q; Corbo, Joseph C; Kefalov, Vladimir J

    2015-12-02

    Continuous visual perception and the dark adaptation of vertebrate photoreceptors after bright light exposure require recycling of their visual chromophore through a series of reactions in the retinal pigmented epithelium (RPE visual cycle). Light-driven chromophore consumption by photoreceptors is greater in daytime vs. nighttime, suggesting that correspondingly higher activity of the visual cycle may be required. However, as rod photoreceptors are saturated in bright light, the continuous turnover of their chromophore by the visual cycle throughout the day would not contribute to vision. Whether the recycling of chromophore that drives rod dark adaptation is regulated by the circadian clock and light exposure is unknown. Here, we demonstrate that mouse rod dark adaptation is slower during the day or after light pre-exposure. This surprising daytime suppression of the RPE visual cycle was accompanied by light-driven reduction in expression of Rpe65, a key enzyme of the RPE visual cycle. Notably, only rods in melatonin-proficient mice were affected by this daily visual cycle modulation. Our results demonstrate that the circadian clock and light exposure regulate the recycling of chromophore in the RPE visual cycle. This daily melatonin-driven modulation of rod dark adaptation could potentially protect the retina from light-induced damage during the day.

  4. Circadian and light-driven regulation of rod dark adaptation

    PubMed Central

    Xue, Yunlu; Shen, Susan Q.; Corbo, Joseph C.; Kefalov, Vladimir J.

    2015-01-01

    Continuous visual perception and the dark adaptation of vertebrate photoreceptors after bright light exposure require recycling of their visual chromophore through a series of reactions in the retinal pigmented epithelium (RPE visual cycle). Light-driven chromophore consumption by photoreceptors is greater in daytime vs. nighttime, suggesting that correspondingly higher activity of the visual cycle may be required. However, as rod photoreceptors are saturated in bright light, the continuous turnover of their chromophore by the visual cycle throughout the day would not contribute to vision. Whether the recycling of chromophore that drives rod dark adaptation is regulated by the circadian clock and light exposure is unknown. Here, we demonstrate that mouse rod dark adaptation is slower during the day or after light pre-exposure. This surprising daytime suppression of the RPE visual cycle was accompanied by light-driven reduction in expression of Rpe65, a key enzyme of the RPE visual cycle. Notably, only rods in melatonin-proficient mice were affected by this daily visual cycle modulation. Our results demonstrate that the circadian clock and light exposure regulate the recycling of chromophore in the RPE visual cycle. This daily melatonin-driven modulation of rod dark adaptation could potentially protect the retina from light-induced damage during the day. PMID:26626567

  5. Regulation of nuclear reactors by duplexed control rods; Linearized analysis

    SciTech Connect

    Haidar, N.H.S. ); Diab, H.B. )

    1991-10-01

    In this paper the dynamic behavior of a duplex control rod for a nuclear reactor is analyzed by linearized modeling. A simulation-aided design for this duplex, which has performance and safety characteristics that are improved over those of conventional single control rods with the same stability margins, is reported.

  6. Calcium feedback and sensitivity regulation in primate rods

    PubMed Central

    1991-01-01

    Membrane current was recorded from a single primate rod with a suction pipette while the cell was bath perfused with solutions maintained at a temperature of approximately 38 degrees C. A transient inward current was observed at the onset of bright illumination after briefly exposing the outer segment in darkness to Ringer's (Locke) solution containing 3- isobutyl-1-methylxanthine (IBMX), an inhibitor of cGMP phosphodiesterase. After briefly removing external Na+ from around the outer segment in darkness, a similar current was observed upon Na+ restoration in bright light. By analogy to amphibian rods, this inward current was interpreted to represent the activity of an electrogenic Na(+)-dependent Ca2+ efflux, which under physiological conditions in the light is expected to reduce the free Ca2+ in the outer segment and provide negative feedback (the "Ca2+ feedback") to the phototransduction process. The exchange current had a saturated amplitude of up to approximately 5 pA and a decline time course that appeared to have more than one exponential component. In the absence of the Ca2+ feedback, made possible by removing the Ca2+ influx and efflux at the outer segment using a 0 Na(+)-0 Ca2+ external solution, the response of a rod to a dim flash was two to three times larger and had a longer time to peak than in physiological solution. These changes can be approximately accounted for by a simple model describing the Ca2+ feedback in primate rods. The dark hydrolytic rate for cGMP was estimated to be 1.2 s-1. The incremental hydrolytic rate, beta*(t), activated by one photoisomerization was approximately 0.09 s-1 at its peak, with a time-integrated activity, integral of beta*(t)dt, of approximately 0.033, both numbers being derived assuming spatial homogeneity in the outer segment. Finally, we have found that primate rods adapt to light in much the same way as amphibian and other mammalian rods, such as showing a Weber-Fechner relation between flash sensitivity and

  7. FGF Signaling Regulates Rod Photoreceptor Cell Maintenance and Regeneration in Zebrafish

    PubMed Central

    Qin, Zhao; Kidd, Ambrose R.; Thomas, Jennifer L.; Poss, Kenneth D.; Hyde, David R.; Raymond, Pamela A.; Thummel, Ryan

    2011-01-01

    Fgf signaling is required for many biological processes involving the regulation of cell proliferation and maintenance, including embryonic patterning, tissue homeostasis, wound healing, and cancer progression. Although the function of Fgf signaling is suggested in several different regeneration models, including appendage regeneration in amphibians and fin and heart regeneration in zebrafish, it has not yet been studied during zebrafish photoreceptor cell regeneration. Here we demonstrate that intravitreal injections of FGF-2 induced rod precursor cell proliferation and photoreceptor cell neuroprotection during intense light damage. Using the dominant-negative Tg(hsp70:dn-fgfr1) transgenic line, we found that Fgf signaling was required for homeostasis of rod, but not cone, photoreceptors. Even though fgfr1 is expressed in both rod and cone photoreceptors, we found that Fgf signaling differentially affected the regeneration of cone and rod photoreceptors in the light-damaged retina, with the dominant-negative hsp70:dn-fgfr1 transgene significantly repressing rod photoreceptor regeneration without affecting cone photoreceptors. These data suggest that rod photoreceptor homeostasis and regeneration is Fgf-dependent and that rod and cone photoreceptors in adult zebrafish are regulated by different signaling pathways. PMID:21945172

  8. miR Cluster 143/145 Directly Targets Nrl and Regulates Rod Photoreceptor Development.

    PubMed

    Sreekanth, Sreekumaran; Rasheed, Vazhanthodi A; Soundararajan, Lalitha; Antony, Jayesh; Saikia, Minakshi; Sivakumar, Krishnankutty Chandrika; Das, Ani V

    2016-11-23

    Retinal histogenesis requires coordinated and temporal functioning of factors by which different cell types are generated from multipotent progenitors. Development of rod photoreceptors is regulated by multiple transcription factors, and Nrl is one of the major factors involved in their fate specification. Presence or absence of Nrl at the postnatal stages decides the generation of cone photoreceptors or other later retinal cells. This suggests the need for regulated expression of Nrl in order to accelerate the generation of other cell types during retinal development. We found that miR cluster 143/145, comprising miR-143 and miR-145, targets and imparts a posttranscriptional inhibition of Nrl. Expression of both miRNAs was differentially regulated during retinal development and showed least expression at PN1 stage in which most of the rod photoreceptors are generated. Downregulation of rod photoreceptor regulators and markers upon miR cluster 143/145 overexpression demonstrated that this cluster indeed negatively regulates rod photoreceptors. Further, we prove that Nrl positively regulates miR cluster 143/145, thus establishing a feedback loop regulatory mechanism. This may be one possible mechanism by which Nrl is posttranscriptionally regulated to facilitate the generation of other cell types in retina.

  9. LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury

    PubMed Central

    Wang, Weiwei; Townes-Anderson, Ellen

    2015-01-01

    Purpose Rod photoreceptors retract their axon terminals and develop neuritic sprouts in response to retinal detachment and reattachment, respectively. This study examines the role of LIM kinase (LIMK), a component of RhoA and Rac pathways, in the presynaptic structural remodeling of rod photoreceptors. Methods Phosphorylated LIMK (p-LIMK), the active form of LIMK, was examined in salamander retina with Western blot and confocal microscopy. Axon length within the first 7 hours and process growth after 3 days of culture were assessed in isolated rod photoreceptors treated with inhibitors of upstream regulators ROCK and p21-activated kinase (Pak) (Y27632 and IPA-3) and a direct LIMK inhibitor (BMS-5). Porcine retinal explants were also treated with BMS-5 and analyzed 24 hours after detachment. Because Ca2+ influx contributes to axonal retraction, L-type channels were blocked in some experiments with nicardipine. Results Phosphorylated LIMK is present in rod terminals during retraction and in newly formed processes. Axonal retraction over 7 hours was significantly reduced by inhibition of LIMK or its regulators, ROCK and Pak. Process growth was reduced by LIMK or Pak inhibition especially at the basal (axon-bearing) region of the rod cells. Combining Ca2+ channel and LIMK inhibition had no additional effect on retraction but did further inhibit sprouting after 3 days. In detached porcine retina, LIMK inhibition reduced rod axonal retraction and improved retinal morphology. Conclusions Thus structural remodeling, in the form of either axonal retraction or neuritic growth, requires LIMK activity. LIM kinase inhibition may have therapeutic potential for reducing pathologic rod terminal plasticity after retinal injury. PMID:26658506

  10. Transcriptional Regulation of Rod Photoreceptor Homeostasis Revealed by In Vivo NRL Targetome Analysis

    PubMed Central

    Hao, Hong; Kim, Douglas S.; Klocke, Bernward; Johnson, Kory R.; Cui, Kairong; Gotoh, Norimoto; Zang, Chongzhi; Gregorski, Janina; Gieser, Linn; Peng, Weiqun; Fann, Yang; Seifert, Martin; Zhao, Keji; Swaroop, Anand

    2012-01-01

    A stringent control of homeostasis is critical for functional maintenance and survival of neurons. In the mammalian retina, the basic motif leucine zipper transcription factor NRL determines rod versus cone photoreceptor cell fate and activates the expression of many rod-specific genes. Here, we report an integrated analysis of NRL-centered gene regulatory network by coupling chromatin immunoprecipitation followed by high-throughput sequencing (ChIP–Seq) data from Illumina and ABI platforms with global expression profiling and in vivo knockdown studies. We identified approximately 300 direct NRL target genes. Of these, 22 NRL targets are associated with human retinal dystrophies, whereas 95 mapped to regions of as yet uncloned retinal disease loci. In silico analysis of NRL ChIP–Seq peak sequences revealed an enrichment of distinct sets of transcription factor binding sites. Specifically, we discovered that genes involved in photoreceptor function include binding sites for both NRL and homeodomain protein CRX. Evaluation of 26 ChIP–Seq regions validated their enhancer functions in reporter assays. In vivo knockdown of 16 NRL target genes resulted in death or abnormal morphology of rod photoreceptors, suggesting their importance in maintaining retinal function. We also identified histone demethylase Kdm5b as a novel secondary node in NRL transcriptional hierarchy. Exon array analysis of flow-sorted photoreceptors in which Kdm5b was knocked down by shRNA indicated its role in regulating rod-expressed genes. Our studies identify candidate genes for retinal dystrophies, define cis-regulatory module(s) for photoreceptor-expressed genes and provide a framework for decoding transcriptional regulatory networks that dictate rod homeostasis. PMID:22511886

  11. Regulation of Noncoding Transcriptome in Developing Photoreceptors by Rod Differentiation Factor NRL.

    PubMed

    Zelinger, Lina; Karakülah, Gökhan; Chaitankar, Vijender; Kim, Jung-Woong; Yang, Hyun-Jin; Brooks, Matthew J; Swaroop, Anand

    2017-09-01

    Transcriptome analysis by next generation sequencing allows qualitative and quantitative profiling of expression patterns associated with development and disease. However, most transcribed sequences do not encode proteins, and little is known about the functional relevance of noncoding (nc) transcriptome in neuronal subtypes. The goal of this study was to perform a comprehensive analysis of long noncoding (lncRNAs) and antisense (asRNAs) RNAs expressed in mouse retinal photoreceptors. Transcriptomic profiles were generated at six developmental time points from flow-sorted Nrlp-GFP (rods) and Nrlp-GFP;Nrl-/- (S-cone like) mouse photoreceptors. Bioinformatic analysis was performed to identify novel noncoding transcripts and assess their regulation by rod differentiation factor neural retina leucine zipper (NRL). In situ hybridization (ISH) was used for validation and cellular localization. NcRNA profiles demonstrated dynamic yet specific expression signature and coexpression clusters during rod development. In addition to currently annotated 586 lncRNAs and 454 asRNAs, we identified 1037 lncRNAs and 243 asRNAs by de novo assembly. Of these, 119 lncRNAs showed altered expression in the absence of NRL and included NRL binding sites in their promoter/enhancer regions. ISH studies validated the expression of 24 lncRNAs (including 12 previously unannotated) and 4 asRNAs in photoreceptors. Coexpression analysis demonstrated 63 functional modules and 209 significant antisense-gene correlations, allowing us to predict possible role of these lncRNAs in rods. Our studies reveal coregulation of coding and noncoding transcripts in rod photoreceptors by NRL and establish the framework for deciphering the function of ncRNAs during retinal development.

  12. Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis.

    PubMed

    Hao, Hong; Kim, Douglas S; Klocke, Bernward; Johnson, Kory R; Cui, Kairong; Gotoh, Norimoto; Zang, Chongzhi; Gregorski, Janina; Gieser, Linn; Peng, Weiqun; Fann, Yang; Seifert, Martin; Zhao, Keji; Swaroop, Anand

    2012-01-01

    A stringent control of homeostasis is critical for functional maintenance and survival of neurons. In the mammalian retina, the basic motif leucine zipper transcription factor NRL determines rod versus cone photoreceptor cell fate and activates the expression of many rod-specific genes. Here, we report an integrated analysis of NRL-centered gene regulatory network by coupling chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-Seq) data from Illumina and ABI platforms with global expression profiling and in vivo knockdown studies. We identified approximately 300 direct NRL target genes. Of these, 22 NRL targets are associated with human retinal dystrophies, whereas 95 mapped to regions of as yet uncloned retinal disease loci. In silico analysis of NRL ChIP-Seq peak sequences revealed an enrichment of distinct sets of transcription factor binding sites. Specifically, we discovered that genes involved in photoreceptor function include binding sites for both NRL and homeodomain protein CRX. Evaluation of 26 ChIP-Seq regions validated their enhancer functions in reporter assays. In vivo knockdown of 16 NRL target genes resulted in death or abnormal morphology of rod photoreceptors, suggesting their importance in maintaining retinal function. We also identified histone demethylase Kdm5b as a novel secondary node in NRL transcriptional hierarchy. Exon array analysis of flow-sorted photoreceptors in which Kdm5b was knocked down by shRNA indicated its role in regulating rod-expressed genes. Our studies identify candidate genes for retinal dystrophies, define cis-regulatory module(s) for photoreceptor-expressed genes and provide a framework for decoding transcriptional regulatory networks that dictate rod homeostasis.

  13. Regulation of Noncoding Transcriptome in Developing Photoreceptors by Rod Differentiation Factor NRL

    PubMed Central

    Zelinger, Lina; Karakülah, Gökhan; Chaitankar, Vijender; Kim, Jung-Woong; Yang, Hyun-Jin; Brooks, Matthew J.

    2017-01-01

    Purpose Transcriptome analysis by next generation sequencing allows qualitative and quantitative profiling of expression patterns associated with development and disease. However, most transcribed sequences do not encode proteins, and little is known about the functional relevance of noncoding (nc) transcriptome in neuronal subtypes. The goal of this study was to perform a comprehensive analysis of long noncoding (lncRNAs) and antisense (asRNAs) RNAs expressed in mouse retinal photoreceptors. Methods Transcriptomic profiles were generated at six developmental time points from flow-sorted Nrlp-GFP (rods) and Nrlp-GFP;Nrl−/− (S-cone like) mouse photoreceptors. Bioinformatic analysis was performed to identify novel noncoding transcripts and assess their regulation by rod differentiation factor neural retina leucine zipper (NRL). In situ hybridization (ISH) was used for validation and cellular localization. Results NcRNA profiles demonstrated dynamic yet specific expression signature and coexpression clusters during rod development. In addition to currently annotated 586 lncRNAs and 454 asRNAs, we identified 1037 lncRNAs and 243 asRNAs by de novo assembly. Of these, 119 lncRNAs showed altered expression in the absence of NRL and included NRL binding sites in their promoter/enhancer regions. ISH studies validated the expression of 24 lncRNAs (including 12 previously unannotated) and 4 asRNAs in photoreceptors. Coexpression analysis demonstrated 63 functional modules and 209 significant antisense-gene correlations, allowing us to predict possible role of these lncRNAs in rods. Conclusions Our studies reveal coregulation of coding and noncoding transcripts in rod photoreceptors by NRL and establish the framework for deciphering the function of ncRNAs during retinal development. PMID:28863214

  14. Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina

    PubMed Central

    Babai, Norbert; Thoreson, Wallace B

    2009-01-01

    We tested whether horizontal cells (HCs) provide feedback that regulates the Ca2+ current (ICa) of rods in salamander and mouse retinas. In both species, hyperpolarizing HCs by puffing a glutamate antagonist, 6,7-dinitro-quinoxaline-2,3-dione (DNQX), onto HC processes caused a negative shift in the voltage dependence of rod ICa and increased its peak amplitude. Conversely, depolarizing HCs by puffing kainic acid (KA) into the outer plexiform layer (OPL) caused a positive voltage shift and decreased rod ICa. Experiments on salamander retina showed that these effects were blocked by addition of the pH buffer, Hepes. Intracellular calcium concentration ([Ca2+]i) was examined in rods by confocal microscopy after loading salamander and mouse retinal slices with Fluo-4. Rods were depolarized to near the dark resting potential by bath application of high K+ solutions. Hyperpolarizing HCs with 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo[f]quinoxaline (NBQX) enhanced high K+-evoked Ca2+ increases whereas depolarizing HCs with KA inhibited Ca2+ increases. In both species these effects of NBQX and KA were blocked by addition of Hepes. Thus, like HC feedback in cones, changes in HC membrane potential modulate rod ICa thereby regulating rod [Ca2+]i at physiological voltages, in both mouse and salamander retinas. By countering the reduced synaptic output that accompanies hyperpolarization of rods to light, HC feedback will subtract spatially averaged luminance levels from the responses of individual rods to local changes. The finding that HC to rod feedback is present in both amphibian and mammalian species shows that this mechanism is highly conserved across vertebrate retinas. PMID:19332495

  15. Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina.

    PubMed

    Babai, Norbert; Thoreson, Wallace B

    2009-05-15

    We tested whether horizontal cells (HCs) provide feedback that regulates the Ca(2+) current (I(Ca)) of rods in salamander and mouse retinas. In both species, hyperpolarizing HCs by puffing a glutamate antagonist, 6,7-dinitro-quinoxaline-2,3-dione (DNQX), onto HC processes caused a negative shift in the voltage dependence of rod I(Ca) and increased its peak amplitude. Conversely, depolarizing HCs by puffing kainic acid (KA) into the outer plexiform layer (OPL) caused a positive voltage shift and decreased rod I(Ca.) Experiments on salamander retina showed that these effects were blocked by addition of the pH buffer, Hepes. Intracellular calcium concentration ([Ca(2+)](i)) was examined in rods by confocal microscopy after loading salamander and mouse retinal slices with Fluo-4. Rods were depolarized to near the dark resting potential by bath application of high K(+) solutions. Hyperpolarizing HCs with 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo[f]quinoxaline (NBQX) enhanced high K(+)-evoked Ca(2+) increases whereas depolarizing HCs with KA inhibited Ca(2+) increases. In both species these effects of NBQX and KA were blocked by addition of Hepes. Thus, like HC feedback in cones, changes in HC membrane potential modulate rod I(Ca) thereby regulating rod [Ca(2+)](i) at physiological voltages, in both mouse and salamander retinas. By countering the reduced synaptic output that accompanies hyperpolarization of rods to light, HC feedback will subtract spatially averaged luminance levels from the responses of individual rods to local changes. The finding that HC to rod feedback is present in both amphibian and mammalian species shows that this mechanism is highly conserved across vertebrate retinas.

  16. Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.

    PubMed

    Ramamurthy, Vasanth; Jolicoeur, Christine; Koutroumbas, Demetra; Mühlhans, Johanna; Le, Yun-Zheng; Hauswirth, William W; Giessl, Andreas; Cayouette, Michel

    2014-10-15

    The development and maintenance of protein compartmentalization is essential for neuronal function. A striking example is observed in light-sensing photoreceptors, in which the apical sensory cilium is subdivided into an inner and outer segment, each containing specific proteins essential for vision. It remains unclear, however, how such polarized protein localization is regulated. We report here that the endocytic adaptor protein Numb localizes to the inner, but not the outer segment of mouse photoreceptor cilia. Rod photoreceptor-specific inactivation of numb in vivo leads to progressive photoreceptor degeneration, indicating an essential role for Numb in photoreceptor cell biology. Interestingly, we report that loss of Numb in photoreceptors does not affect the localization of outer segment disk membrane proteins, such as rhodopsin, Peripherin-rds, Rom-1, and Abca4, but significantly disrupts the localization of the rod cyclic nucleotide-gated (Cng) channels, which accumulates on the inner segment plasma membrane in addition to its normal localization to the outer segments. Mechanistically, we show that Numb interacts with both subunits of the Cng channel and promotes the trafficking of Cnga1 to the recycling endosome. These results suggest a model in which Numb prevents targeting of Cng channels to the inner segment, by promoting their trafficking through the recycling endosome, where they can be sorted for specific delivery to the outer segment. This study uncovers a novel mechanism regulating polarized protein delivery in light-sensing cilia, raising the possibility that Numb plays a part in the regulation of protein trafficking in other types of cilia. Copyright © 2014 the authors 0270-6474/14/3413976-12$15.00/0.

  17. Regulation of rhodopsin-eGFP distribution in transgenic xenopus rod outer segments by light.

    PubMed

    Haeri, Mohammad; Calvert, Peter D; Solessio, Eduardo; Pugh, Edward N; Knox, Barry E

    2013-01-01

    The rod outer segment (OS), comprised of tightly stacked disk membranes packed with rhodopsin, is in a dynamic equilibrium governed by a diurnal rhythm with newly synthesized membrane inserted at the OS base balancing membrane loss from the distal tip via disk shedding. Using transgenic Xenopus and live cell confocal imaging, we found OS axial variation of fluorescence intensity in cells expressing a fluorescently tagged rhodopsin transgene. There was a light synchronized fluctuation in intensity, with higher intensity in disks formed at night and lower intensity for those formed during the day. This fluctuation was absent in constant light or dark conditions. There was also a slow modulation of the overall expression level that was not synchronized with the lighting cycle or between cells in the same retina. The axial variations of other membrane-associated fluorescent proteins, eGFP-containing two geranylgeranyl acceptor sites and eGFP fused to the transmembrane domain of syntaxin, were greatly reduced or not detectable, respectively. In acutely light-adapted rods, an arrestin-eGFP fusion protein also exhibited axial variation. Both the light-sensitive Rho-eGFP and arrestin-eGFP banding were in phase with the previously characterized birefringence banding (Kaplan, Invest. Ophthalmol. Vis. Sci. 21, 395-402 1981). In contrast, endogenous rhodopsin did not exhibit such axial variation. Thus, there is an axial inhomogeneity in membrane composition or structure, detectable by the rhodopsin transgene density distribution and regulated by the light cycle, implying a light-regulated step for disk assembly in the OS. The impact of these results on the use of chimeric proteins with rhodopsin fused to fluorescent proteins at the carboxyl terminus is discussed.

  18. Regulation of cGMP levels by guanylate cyclase in truncated frog rod outer segments

    PubMed Central

    1989-01-01

    Cyclic GMP is the second messenger in phototransduction and regulates the photoreceptor current. In the present work, we tried to understand the regulation mechanism of cytoplasmic cGMP levels in frog photoreceptors by measuring the photoreceptor current using a truncated rod outer segment (tROS) preparation. Since exogenously applied substance diffuses into tROS from the truncated end, we could examine the biochemical reactions relating to the cGMP metabolism by manipulating the cytoplasmic chemical condition. In tROS, exogenously applied GTP produced a dark current whose amplitude was half-maximal at approximately 0.4 mM GTP. The conductance for this current was suppressed by light in a fashion similar to when it is activated by cGMP. In addition, no current was produced in the absence of Mg2+, which is known to be necessary for the guanylate cyclase activity. These results indicate that guanylate cyclase was present in tROS and synthesized cGMP from exogenously applied GTP. The enzyme activity was distributed throughout the rod outer segment. The amount of synthesized cGMP increased as the cytoplasmic Ca2+ concentration of tROS decreased, which indicated the activation of guanylate cyclase at low Ca2+ concentrations. Half-maximal effect of Ca2+ was observed at approximately 100 nM. tROS contained the proteins involved in the phototransduction mechanism and therefore, we could examine the regulation of the light response waveform by Ca2+. At low Ca2+ concentrations, the time course of the light response was speeded up probably because cGMP recovery was facilitated by activation of the cyclase. Then, if the cytoplasmic Ca2+ concentration of a photoreceptor decreases during light stimulation, the Ca2+ decrease may explain the acceleration of the light response during light adaptation. In tROS, however, we did observe an acceleration during repetitive light flashes when the cytoplasmic Ca2+ concentration increased during the stimulation. This result suggests the

  19. Developmental time rather than local environment regulates the schedule of epithelial polarization in the zebrafish neural rod

    PubMed Central

    2013-01-01

    Background Morphogenesis requires developmental processes to occur both at the right time and in the right place. During neural tube formation in the zebrafish embryo, the generation of the apical specializations of the lumen must occur in the center of the neural rod after the neural cells have undergone convergence, invagination and interdigitation across the midline. How this coordination is achieved is uncertain. One possibility is that environmental signaling at the midline of the neural rod controls the schedule of apical polarization. Alternatively, polarization could be regulated by a timing mechanism and then independent morphogenetic processes ensure the cells are in the correct spatial location. Results Ectopic transplantation demonstrates the local environment of the neural midline is not required for neural cell polarization. Neural cells can self-organize into epithelial cysts in ectopic locations in the embryo and also in three-dimensional gel cultures. Heterochronic transplants demonstrate that the schedule of polarization and the specialized cell divisions characteristic of the neural rod are more strongly regulated by time than local environmental signals. The cells’ schedule for polarization is set prior to gastrulation, is stable through several rounds of cell division and appears independent of the morphogenetic movements of gastrulation and neurulation. Conclusions Time rather than local environment regulates the schedule of epithelial polarization in zebrafish neural rod. PMID:23521850

  20. Developmentally Regulated Linker Histone H1c Promotes Heterochromatin Condensation and Mediates Structural Integrity of Rod Photoreceptors in Mouse Retina*

    PubMed Central

    Popova, Evgenya Y.; Grigoryev, Sergei A.; Fan, Yuhong; Skoultchi, Arthur I.; Zhang, Samuel S.; Barnstable, Colin J.

    2013-01-01

    Mature rod photoreceptor cells contain very small nuclei with tightly condensed heterochromatin. We observed that during mouse rod maturation, the nucleosomal repeat length increases from 190 bp at postnatal day 1 to 206 bp in the adult retina. At the same time, the total level of linker histone H1 increased reaching the ratio of 1.3 molecules of total H1 per nucleosome, mostly via a dramatic increase in H1c. Genetic elimination of the histone H1c gene is functionally compensated by other histone variants. However, retinas in H1c/H1e/H10 triple knock-outs have photoreceptors with bigger nuclei, decreased heterochromatin area, and notable morphological changes suggesting that the process of chromatin condensation and rod cell structural integrity are partly impaired. In triple knock-outs, nuclear chromatin exposed several epigenetic histone modification marks masked in the wild type chromatin. Dramatic changes in exposure of a repressive chromatin mark, H3K9me2, indicate that during development linker histone plays a role in establishing the facultative heterochromatin territory and architecture in the nucleus. During retina development, the H1c gene and its promoter acquired epigenetic patterns typical of rod-specific genes. Our data suggest that histone H1c gene expression is developmentally up-regulated to promote facultative heterochromatin in mature rod photoreceptors. PMID:23645681

  1. Temporal regulation of genes encoding the flagellar proximal rod in Caulobacter crescentus.

    PubMed

    Boyd, C H; Gober, J W

    2001-01-01

    The gram-negative bacterium Caulobacter crescentus has a life cycle that includes two distinct and separable developmental stages, a motile swarmer phase and a sessile stalked phase. The cell cycle-controlled biogenesis of the single polar flagellum of the swarmer cell is the best-studied aspect of this developmental program. The flagellar regulon is arranged into a rigid trans-acting hierarchy of gene expression in which successful expression of early genes is required for the expression of genes that are later in the hierarchy and in which the order of gene expression mirrors the order of assembly of gene products into the completed flagellum. The flgBC-fliE genes were identified as a result of the C. crescentus genome sequencing project and encode the homologues of two flagellar proximal rod proteins, FlgB and FlgC, and one conserved protein, FliE, that is of unknown function. Footprint assays on a DNA fragment containing the operon promoter as well as in vivo mutant suppressor analysis of promoter mutations indicate that this operon is controlled by the cell cycle response regulator CtrA, which with sigma(70) is responsible for regulating transcription of other early flagellar genes in C. crescentus. Promoter analysis, timing of expression, and epistasis experiments place these genes outside of the flagellar regulatory hierarchy; they are expressed in class II mutants, and flgB deletions do not prevent class III gene expression. This operon is also unusual in that it is expressed from a promoter that is divergent from the class II operon containing fliP, which encodes a member of the flagellum-specific protein export apparatus.

  2. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem.

    PubMed Central

    Stern, J H; Kaupp, U B; MacLeish, P R

    1986-01-01

    The effect of calcium ions on the cGMP-activated current of outer segment membrane was examined by the excised-patch technique. Changes in the extracellular calcium concentration had marked effects on the cGMP-activated current, while changes in intracellular calcium concentration were ineffective. Changes in calcium concentration in the absence of cGMP had little, if any, effect on membrane conductance. These results suggest that both intracellular cGMP and extracellular calcium can directly affect the conductance underlying the light response in rod cells. The pharmacological agent l-cis-diltiazem reversibly inhibited the cGMP-activated current when applied to the intracellular side of an excised patch. When superfused over intact rod cells, l-cis-diltiazem reversibly blocked much of the normal light response. The isomer, d-cis-diltiazem, did not significantly affect either patches or intact rod cells. Thus, the light-regulated conductance has binding sites for both calcium and cGMP that may interact during the normal light response in rod cells and a site specific for l-cis-diltiazem that can be used to identify and further study the conductance mechanism. PMID:3006029

  3. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem.

    PubMed

    Stern, J H; Kaupp, U B; MacLeish, P R

    1986-02-01

    The effect of calcium ions on the cGMP-activated current of outer segment membrane was examined by the excised-patch technique. Changes in the extracellular calcium concentration had marked effects on the cGMP-activated current, while changes in intracellular calcium concentration were ineffective. Changes in calcium concentration in the absence of cGMP had little, if any, effect on membrane conductance. These results suggest that both intracellular cGMP and extracellular calcium can directly affect the conductance underlying the light response in rod cells. The pharmacological agent l-cis-diltiazem reversibly inhibited the cGMP-activated current when applied to the intracellular side of an excised patch. When superfused over intact rod cells, l-cis-diltiazem reversibly blocked much of the normal light response. The isomer, d-cis-diltiazem, did not significantly affect either patches or intact rod cells. Thus, the light-regulated conductance has binding sites for both calcium and cGMP that may interact during the normal light response in rod cells and a site specific for l-cis-diltiazem that can be used to identify and further study the conductance mechanism.

  4. Retinal S Antigen Identified as the 48K Protein Regulating Light-Dependent Phosphodiesterase in Rods

    NASA Astrophysics Data System (ADS)

    Pfister, C.; Chabre, M.; Plouet, J.; Tuyen, V. V.; de Kozak, Y.; Faure, J. P.; Kuhn, H.

    1985-05-01

    Retinal S antigen chromatographically purified from whole retina, induces experimental autoimmune uveoretinitis in laboratory animals. The 48K protein, a soluble protein found in rod outer segments, is purified through its specific binding to photoexcited rhodopsin and is involved in the quenching of light-induced guanosine 3',5'-monophosphate-phosphodiesterase activity. Biochemical, immunological, functional, and pathological tests showed that retinal S antigen and the 48K protein are identical.

  5. Interactions regulating the head-to-tail directed assembly of biological Janus rods

    DOE PAGES

    Greene, A. C.; Bachand, M.; Gomez, A.; ...

    2017-03-31

    We can generalize the directed, head-to-tail self-assembly of microtubule filaments in the context of Janus colloidal rods. Specifically, their assembly at the tens of micron-length scale involves a careful balance between long-range electrostatic repulsion and short-range attractive forces. We show that the addition of counterion salts increases the rate of directed assembly by screening the electrostatic forces and enhancing the effectiveness of short-range interactions at the microtubule ends.

  6. Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae

    PubMed Central

    Alvaro, Christopher G.; Aindow, Ann; Thorner, Jeremy

    2016-01-01

    G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate stimulus-dependent activation of cognate heterotrimeric G-proteins, triggering ensuing downstream cellular responses. Tight regulation of GPCR-evoked pathways is required because prolonged stimulation can be detrimental to an organism. Ste2, a GPCR in Saccharomyces cerevisiae that mediates response of MATa haploids to the peptide mating pheromone α-factor, is down-regulated by both constitutive and agonist-induced endocytosis. Efficient agonist-stimulated internalization of Ste2 requires its association with an adaptor protein, the α-arrestin Rod1/Art4, which recruits the HECT-domain ubiquitin ligase Rsp5, allowing for ubiquitinylation of the C-terminal tail of the receptor and its engagement by the clathrin-dependent endocytic machinery. We previously showed that dephosphorylation of Rod1 by calcineurin (phosphoprotein phosphatase 2B) is required for optimal Rod1 function in Ste2 down-regulation. We show here that negative regulation of Rod1 by phosphorylation is mediated by two distinct stress-activated protein kinases, Snf1/AMPK and Ypk1/SGK1, and demonstrate both in vitro and in vivo that this phospho-regulation impedes the ability of Rod1 to promote mating pathway desensitization. These studies also revealed that, in the absence of its phosphorylation, Rod1 can promote adaptation independently of Rsp5-mediated receptor ubiquitinylation, consistent with recent evidence that α-arrestins can contribute to cargo recognition by both clathrin-dependent and clathrin-independent mechanisms. However, in cells lacking a component (formin Bni1) required for clathrin-independent entry, Rod1 derivatives that are largely unphosphorylated and unable to associate with Rsp5 still promote efficient adaptation, indicating a third mechanism by which this α-arrestin promotes desensitization of the pheromone-response pathway. PMID:26920760

  7. Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae.

    PubMed

    Alvaro, Christopher G; Aindow, Ann; Thorner, Jeremy

    2016-05-01

    G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate stimulus-dependent activation of cognate heterotrimeric G-proteins, triggering ensuing downstream cellular responses. Tight regulation of GPCR-evoked pathways is required because prolonged stimulation can be detrimental to an organism. Ste2, a GPCR in Saccharomyces cerevisiae that mediates response of MATa haploids to the peptide mating pheromone α-factor, is down-regulated by both constitutive and agonist-induced endocytosis. Efficient agonist-stimulated internalization of Ste2 requires its association with an adaptor protein, the α-arrestin Rod1/Art4, which recruits the HECT-domain ubiquitin ligase Rsp5, allowing for ubiquitinylation of the C-terminal tail of the receptor and its engagement by the clathrin-dependent endocytic machinery. We previously showed that dephosphorylation of Rod1 by calcineurin (phosphoprotein phosphatase 2B) is required for optimal Rod1 function in Ste2 down-regulation. We show here that negative regulation of Rod1 by phosphorylation is mediated by two distinct stress-activated protein kinases, Snf1/AMPK and Ypk1/SGK1, and demonstrate both in vitro and in vivo that this phospho-regulation impedes the ability of Rod1 to promote mating pathway desensitization. These studies also revealed that, in the absence of its phosphorylation, Rod1 can promote adaptation independently of Rsp5-mediated receptor ubiquitinylation, consistent with recent evidence that α-arrestins can contribute to cargo recognition by both clathrin-dependent and clathrin-independent mechanisms. However, in cells lacking a component (formin Bni1) required for clathrin-independent entry, Rod1 derivatives that are largely unphosphorylated and unable to associate with Rsp5 still promote efficient adaptation, indicating a third mechanism by which this α-arrestin promotes desensitization of the pheromone-response pathway.

  8. Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1

    PubMed Central

    Spellman, Rachel; Llorian, Miriam; Smith, Christopher W.J.

    2007-01-01

    Summary Among the targets of the repressive splicing regulator, polypyrimidine tract binding protein (PTB) is its own pre-mRNA, where PTB-induced exon 11 skipping produces an RNA substrate for nonsense-mediated decay (NMD). To identify additional PTB-regulated alternative splicing events, we used quantitative proteomic analysis of HeLa cells after knockdown of PTB. Apart from loss of PTB, the only change was upregulation of the neuronally restricted nPTB, resulting from decreased skipping of nPTB exon 10, a splicing event that leads to NMD of nPTB mRNA. Compared with knockdown of PTB alone, simultaneous knockdown of PTB and nPTB led to larger changes in alternative splicing of known and newly identified PTB-regulated splicing events. Strikingly, the hematopoietic PTB paralog ROD1 also switched from a nonproductive splicing pathway upon PTB/nPTB knockdown. Our data indicate crossregulation between PTB and its paralogs via nonproductive alternative splicing and a large degree of functional overlap between PTB and nPTB. PMID:17679092

  9. An Unstable Head-Rod Junction May Promote Folding into the Compact Off-State Conformation of Regulated Myosins

    SciTech Connect

    Brown,J.; Yang, Y.; Reshetnikova, L.; Gourinath, S.; Suvege, D.; Kardos, J.; Hobor, F.; Reutzel, R.; Nyitray, L.; Cohen, C.

    2008-01-01

    The N-terminal region of myosin's rod-like subfragment 2 (S2) joins the two heads of this dimeric molecule and is key to its function. Previously, a crystal structure of this predominantly coiled-coil region was determined for a short fragment (51 residues plus a leucine zipper) of the scallop striated muscle myosin isoform. In that study, the N-terminal 10-14 residues were found to be disordered. We have now determined the structure of the same scallop peptide in three additional crystal environments. In each of two of these structures, improved order has allowed visualization of the entire N-terminus in one chain of the dimeric peptide. We have also compared the melting temperatures of this scallop S2 peptide with those of analogous peptides from three other isoforms. Taken together, these experiments, along with examination of sequences, point to a diminished stability of the N-terminal region of S2 in regulated myosins, compared with those myosins whose regulation is thin filament linked. It seems plain that this isoform-specific instability promotes the off-state conformation of the heads in regulated myosins. We also discuss how myosin isoforms with varied thermal stabilities share the basic capacity to transmit force efficiently in order to produce contraction in their on states.

  10. Poly(acrylic acid)-regulated Synthesis of Rod-Like Calcium Carbonate Nanoparticles for Inducing the Osteogenic Differentiation of MC3T3-E1 Cells.

    PubMed

    Yang, Wei; Yao, Chenxue; Cui, Zhengyang; Luo, Dandan; Lee, In-Seop; Yao, Juming; Chen, Cen; Kong, Xiangdong

    2016-05-06

    Calcium carbonate, especially with nanostructure, has been considered as a good candidate material for bone regeneration due to its excellent biodegradability and osteoconductivity. In this study, rod-like calcium carbonate nanoparticles (Rod-CC NPs) with desired water dispersibility were achieved with the regulation of poly (acrylic acid). Characterization results revealed that the Rod-CC NPs had an average length of 240 nm, a width of 90 nm with an average aspect ratio of 2.60 and a negative ζ-potential of -22.25 ± 0.35 mV. The degradation study illustrated the nanoparticles degraded 23% at pH 7.4 and 45% at pH 5.6 in phosphate-buffered saline (PBS) solution within three months. When cultured with MC3T3-E1 cells, the Rod-CC NPs exhibited a positive effect on the proliferation of osteoblast cells. Alkaline phosphatase (ALP) activity assays together with the osteocalcin (OCN) and bone sialoprotein (BSP) expression observations demonstrated the nanoparticles could induce the differentiation of MC3T3-E1 cells. Our study developed well-dispersed rod-like calcium carbonate nanoparticles which have great potential to be used in bone regeneration.

  11. Poly(acrylic acid)-regulated Synthesis of Rod-Like Calcium Carbonate Nanoparticles for Inducing the Osteogenic Differentiation of MC3T3-E1 Cells

    PubMed Central

    Yang, Wei; Yao, Chenxue; Cui, Zhengyang; Luo, Dandan; Lee, In-Seop; Yao, Juming; Chen, Cen; Kong, Xiangdong

    2016-01-01

    Calcium carbonate, especially with nanostructure, has been considered as a good candidate material for bone regeneration due to its excellent biodegradability and osteoconductivity. In this study, rod-like calcium carbonate nanoparticles (Rod-CC NPs) with desired water dispersibility were achieved with the regulation of poly (acrylic acid). Characterization results revealed that the Rod-CC NPs had an average length of 240 nm, a width of 90 nm with an average aspect ratio of 2.60 and a negative ζ-potential of −22.25 ± 0.35 mV. The degradation study illustrated the nanoparticles degraded 23% at pH 7.4 and 45% at pH 5.6 in phosphate-buffered saline (PBS) solution within three months. When cultured with MC3T3-E1 cells, the Rod-CC NPs exhibited a positive effect on the proliferation of osteoblast cells. Alkaline phosphatase (ALP) activity assays together with the osteocalcin (OCN) and bone sialoprotein (BSP) expression observations demonstrated the nanoparticles could induce the differentiation of MC3T3-E1 cells. Our study developed well-dispersed rod-like calcium carbonate nanoparticles which have great potential to be used in bone regeneration. PMID:27164090

  12. Of Rings and Rods: Regulating Cohesin Entrapment of DNA to Generate Intra- and Intermolecular Tethers.

    PubMed

    Skibbens, Robert V

    2016-10-01

    The clinical relevance of cohesin in DNA repair, tumorigenesis, and severe birth defects continues to fuel efforts in understanding cohesin structure, regulation, and enzymology. Early models depicting huge cohesin rings that entrap two DNA segments within a single lumen are fading into obscurity based on contradictory findings, but elucidating cohesin structure amid a myriad of functions remains challenging. Due in large part to integrated uses of a wide range of methodologies, recent advances are beginning to cast light into the depths that previously cloaked cohesin structure. Additional efforts similarly provide new insights into cohesin enzymology: specifically, the discoveries of ATP-dependent transitions that promote cohesin binding and release from DNA. In combination, these efforts posit a new model that cohesin exists primarily as a relatively flattened structure that entraps only a single DNA molecule and that subsequent ATP hydrolysis, acetylation, and oligomeric assembly tether together individual DNA segments.

  13. Rhodopsin-Regulated Insulin Receptor Signaling Pathway in Rod Photoreceptor Neurons

    PubMed Central

    Rajala, Raju V.S.; Anderson, Robert E.

    2010-01-01

    The retina is an integral part of the central nervous system and retinal cells are known to express insulin receptors (IR), although their function is not known. This article describes recent studies that link the photoactivation of rhodopsin to tyrosine phosphorylation of the IR and subsequent activation of phosphoinositide 3-kinase (PI3K), a neuron survival factor. Our studies suggest that the physiological role of this process is to provide neuroprotection of the retina against light-damage by activating proteins that protect against stress-induced apoptosis. We focus mainly on our recently identified regulation of the IR pathway through the G-protein-coupled receptor rhodopsin. Various mutant and knockout proteins of phototransduction cascade have been used to study the light-induced activation of the retinal IR. Our studies suggest that rhodopsin may have additional previously uncharacterized signaling functions in photoreceptors. PMID:20407846

  14. Of Rings and Rods: Regulating Cohesin Entrapment of DNA to Generate Intra- and Intermolecular Tethers

    PubMed Central

    2016-01-01

    The clinical relevance of cohesin in DNA repair, tumorigenesis, and severe birth defects continues to fuel efforts in understanding cohesin structure, regulation, and enzymology. Early models depicting huge cohesin rings that entrap two DNA segments within a single lumen are fading into obscurity based on contradictory findings, but elucidating cohesin structure amid a myriad of functions remains challenging. Due in large part to integrated uses of a wide range of methodologies, recent advances are beginning to cast light into the depths that previously cloaked cohesin structure. Additional efforts similarly provide new insights into cohesin enzymology: specifically, the discoveries of ATP-dependent transitions that promote cohesin binding and release from DNA. In combination, these efforts posit a new model that cohesin exists primarily as a relatively flattened structure that entraps only a single DNA molecule and that subsequent ATP hydrolysis, acetylation, and oligomeric assembly tether together individual DNA segments. PMID:27788133

  15. Rodding Surgery

    MedlinePlus

    ... operation; anesthesia issues,  Reason for the choice of rod,  Time in the hospital,  Length of recovery time at home,  Pain management including control of muscle spasms,  The rehabilitation plan. It is ...

  16. Automatic safety rod for reactors

    DOEpatents

    Germer, John H.

    1988-01-01

    An automatic safety rod for a nuclear reactor containing neutron absorbing material and designed to be inserted into a reactor core after a loss-of-core flow. Actuation is based upon either a sudden decrease in core pressure drop or the pressure drop decreases below a predetermined minimum value. The automatic control rod includes a pressure regulating device whereby a controlled decrease in operating pressure due to reduced coolant flow does not cause the rod to drop into the core.

  17. Kinetics of Rhodopsin Deactivation and Its Role in Regulating Recovery and Reproducibility of Rod Photoresponse

    PubMed Central

    Caruso, Giovanni; Bisegna, Paolo; Lenoci, Leonardo; Andreucci, Daniele; Gurevich, Vsevolod V.; Hamm, Heidi E.; DiBenedetto, Emmanuele

    2010-01-01

    The single photon response (SPR) in vertebrate phototransduction is regulated by the dynamics of R* during its lifetime, including the random number of phosphorylations, the catalytic activity and the random sojourn time at each phosphorylation level. Because of this randomness the electrical responses are expected to be inherently variable. However the SPR is highly reproducible. The mechanisms that confer to the SPR such a low variability are not completely understood. The kinetics of rhodopsin deactivation is investigated by a Continuous Time Markov Chain (CTMC) based on the biochemistry of rhodopsin activation and deactivation, interfaced with a spatio-temporal model of phototransduction. The model parameters are extracted from the photoresponse data of both wild type and mutant mice, having variable numbers of phosphorylation sites and, with the same set of parameters, the model reproduces both WT and mutant responses. The sources of variability are dissected into its components, by asking whether a random number of turnoff steps, a random sojourn time between steps, or both, give rise to the known variability. The model shows that only the randomness of the sojourn times in each of the phosphorylated states contributes to the Coefficient of Variation (CV) of the response, whereas the randomness of the number of R* turnoff steps has a negligible effect. These results counter the view that the larger the number of decay steps of R*, the more stable the photoresponse is. Our results indicate that R* shutoff is responsible for the variability of the photoresponse, while the diffusion of the second messengers acts as a variability suppressor. PMID:21200415

  18. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL

    PubMed Central

    Hao, Hong; Veleri, Shobi; Sun, Bo; Kim, Douglas S.; Keeley, Patrick W.; Kim, Jung-Woong; Yang, Hyun-Jin; Yadav, Sharda P.; Manjunath, Souparnika H.; Sood, Raman; Liu, Paul; Reese, Benjamin E.; Swaroop, Anand

    2014-01-01

    The Maf-family leucine zipper transcription factor NRL is essential for rod photoreceptor development and functional maintenance in the mammalian retina. Mutations in NRL are associated with human retinopathies, and loss of Nrl in mice leads to a cone-only retina with the complete absence of rods. Among the highly down-regulated genes in the Nrl−/− retina, we identified receptor expression enhancing protein 6 (Reep6), which encodes a member of a family of proteins involved in shaping of membrane tubules and transport of G-protein coupled receptors. Here, we demonstrate the expression of a novel Reep6 isoform (termed Reep6.1) in the retina by exon-specific Taqman assay and rapid analysis of complementary deoxyribonucleic acid (cDNA) ends (5′-RACE). The REEP6.1 protein includes 27 additional amino acids encoded by exon 5 and is specifically expressed in rod photoreceptors of developing and mature retina. Chromatin immunoprecipitation assay identified NRL binding within the Reep6 intron 1. Reporter assays in cultured cells and transfections in retinal explants mapped an intronic enhancer sequence that mediated NRL-directed Reep6.1 expression. We also demonstrate that knockdown of Reep6 in mouse and zebrafish resulted in death of retinal cells. Our studies implicate REEP6.1 as a key functional target of NRL-centered transcriptional regulatory network in rod photoreceptors. PMID:24691551

  19. CONTROL ROD

    DOEpatents

    Walker, D.E.; Matras, S.

    1963-04-30

    This patent shows a method of making a fuel or control rod for a nuclear reactor. Fuel or control material is placed within a tube and plugs of porous metal wool are inserted at both ends. The metal wool is then compacted and the tube compressed around it as by swaging, thereby making the plugs liquid- impervious but gas-pervious. (AEC)

  20. CONTROL ROD

    DOEpatents

    Zinn, W.H.; Ross, H.V.

    1958-11-18

    A control rod is described for a nuclear reactor. In certaln reactor designs it becomes desirable to use a control rod having great width but relatively llttle thickness. This patent is addressed to such a need. The neutron absorbing material is inserted in a triangular tube, leaving volds between the circular insert and the corners of the triangular tube. The material is positioned within the tube by the use of dummy spacers to achleve the desired absorption pattern, then the ends of the tubes are sealed with suitable plugs. The tubes may be welded or soldered together to form two flat surfaces of any desired width, and covered with sheetmetal to protect the tubes from damage. This design provides a control member that will not distort under the action of outside forces or be ruptured by gases generated within the jacketed control member.

  1. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL.

    PubMed

    Hao, Hong; Veleri, Shobi; Sun, Bo; Kim, Douglas S; Keeley, Patrick W; Kim, Jung-Woong; Yang, Hyun-Jin; Yadav, Sharda P; Manjunath, Souparnika H; Sood, Raman; Liu, Paul; Reese, Benjamin E; Swaroop, Anand

    2014-08-15

    The Maf-family leucine zipper transcription factor NRL is essential for rod photoreceptor development and functional maintenance in the mammalian retina. Mutations in NRL are associated with human retinopathies, and loss of Nrl in mice leads to a cone-only retina with the complete absence of rods. Among the highly down-regulated genes in the Nrl(-/-) retina, we identified receptor expression enhancing protein 6 (Reep6), which encodes a member of a family of proteins involved in shaping of membrane tubules and transport of G-protein coupled receptors. Here, we demonstrate the expression of a novel Reep6 isoform (termed Reep6.1) in the retina by exon-specific Taqman assay and rapid analysis of complementary deoxyribonucleic acid (cDNA) ends (5'-RACE). The REEP6.1 protein includes 27 additional amino acids encoded by exon 5 and is specifically expressed in rod photoreceptors of developing and mature retina. Chromatin immunoprecipitation assay identified NRL binding within the Reep6 intron 1. Reporter assays in cultured cells and transfections in retinal explants mapped an intronic enhancer sequence that mediated NRL-directed Reep6.1 expression. We also demonstrate that knockdown of Reep6 in mouse and zebrafish resulted in death of retinal cells. Our studies implicate REEP6.1 as a key functional target of NRL-centered transcriptional regulatory network in rod photoreceptors. Published by Oxford University Press 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  2. Control rod

    SciTech Connect

    Dixon, R.C.; Cearley, J.E.; VanDiemen, P.; Sayre, E.D.; Gordon, G.M.

    1990-02-20

    This patent describes in a nuclear reactor control rod having elongate planar members for absorption of neutrons within a nuclear reactor for control of the nuclear reaction, the elongate planar members being formed of a plurality of tubes arranged side-by-side in abutting contact and joined together. The tube comprises: a tube defining a cylindrical pressure vessel for containment of neutron absorbing poisons. The tube defining constant side wall thickness sufficient to define there within a cylindrical volume for the containment of neutron absorbing poisons and having sufficient side wall thickness to retain the poisons under all anticipated pressures from decomposition of the neutron absorbing poisons; and the tube integrally defining in addition to the cylindrical pressure vessel four discrete right angle corner sections placed at 90{degree} intervals to the side wall of the constant side wall thickness tube; and neutron absorbing poisons confined within the tube for absorption of neutrons for control of the nuclear reaction.

  3. Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein.

    PubMed

    Llopis-Torregrosa, Vicent; Ferri-Blázquez, Alba; Adam-Artigues, Anna; Deffontaines, Emilie; van Heusden, G Paul H; Yenush, Lynne

    2016-07-15

    Cell viability requires adaptation to changing environmental conditions. Ubiquitin-mediated endocytosis plays a crucial role in this process, because it provides a mechanism to remove transport proteins from the membrane. Arrestin-related trafficking proteins are important regulators of the endocytic pathway in yeast, facilitating selective ubiquitylation of target proteins by the E3 ubiquitin ligase, Rsp5. Specifically, Rod1 (Art4) has been reported to regulate the endocytosis of both the Hxt1, Hxt3, and Hxt6 glucose transporters and the Jen1 lactate transporter. Also, the AMP kinase homologue, Snf1, and 14-3-3 proteins have been shown to regulate Jen1 via Rod1. Here, we further characterized the role of Rod1, Snf1, and 14-3-3 in the signal transduction route involved in the endocytic regulation of the Hxt6 high affinity glucose transporter by showing that Snf1 interacts specifically with Rod1 and Rog3 (Art7), that the interaction between the Bmh2 and several arrestin-related trafficking proteins may be modulated by carbon source, and that both the 14-3-3 protein Bmh2 and the Snf1 regulatory domain interact with the arrestin-like domain containing the N-terminal half of Rod1 (amino acids 1-395). Finally, using both co-immunoprecipitation and bimolecular fluorescence complementation, we demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2.

  4. Automatic safety rod for reactors. [LMFBR

    DOEpatents

    Germer, J.H.

    1982-03-23

    An automatic safety rod for a nuclear reactor containing neutron absorbing material and designed to be inserted into a reactor core after a loss-of-flow. Actuation is based upon either a sudden decrease in core pressure drop or the pressure drop decreases below a predetermined minimum value. The automatic control rod includes a pressure regulating device whereby a controlled decrease in operating pressure due to reduced coolant flow does not cause the rod to drop into the core.

  5. Rod examination gauge

    SciTech Connect

    Bacvinskas, W.S.; Bayer, J.E.; Davis, W.W.; Fodor, G.; Kikta, T.J.; Matchett, R.L.; Nilsen, R.J.; Wilczynski, R.

    1991-12-31

    The present invention is directed to a semi-automatic rod examination gauge for performing a large number of exacting measurements on radioactive fuel rods. The rod examination gauge performs various measurements underwater with remote controlled machinery of high reliability. The rod examination gauge includes instruments and a closed circuit television camera for measuring fuel rod length, free hanging bow measurement, diameter measurement, oxide thickness measurement, cladding defect examination, rod ovality measurement, wear mark depth and volume measurement, as well as visual examination. A control system is provided including a programmable logic controller and a computer for providing a programmed sequence of operations for the rod examination and collection of data.

  6. FUEL ROD ASSEMBLY

    DOEpatents

    Hutter, E.

    1959-09-01

    A cluster of nuclear fuel rods aod a tubular casing through which a coolant flows in heat-change contact with the ruel rods are described. The casting is of trefoil section and carries the fuel rods, each of which has two fin engaging the serrated fins of the other two fuel rods, whereby the fuel rods are held in the casing and are interlocked against relative longitudinal movement.

  7. Functional ectopic neuritogenesis by retinal rod bipolar cells is regulated by miR-125b-5p during retinal remodeling in RCS rats.

    PubMed

    Fu, Yan; Hou, Baoke; Weng, Chuanhuang; Liu, Weiping; Dai, Jiaman; Zhao, Congjian; Yin, Zheng Qin

    2017-04-21

    Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and functional consequences of such changes remain unclear. Here, we used Royal College of Surgeon (RCS) rats as a model of retinal degeneration, to study structural changes in rod bipolar cells (RBCs) and the underlying mechanisms of these changes. We found that, with retinal degeneration, RBC dendrites extended into the outer nuclear layer (ONL) of the retina, and the ectopic dendrites formed synapses with the remaining photoreceptors. This ectopic neuritogenesis was associated with brain-derived neurotrophic factor (BDNF) - expression of which was negatively regulated by miR-125b-5p. Overexpression of miR-125b-5p in the retinae of RCS rats diminished RBC ectopic dendrites, and compromised the b-wave of the flash electroretinogram (ERG). In contrast, down-regulation of miR-125b-5p (or exogenous BDNF treatment) increased RBC ectopic dendrites, and improved b-wave. Furthermore, we showed that the regulation of ectopic neuritogenesis by BDNF occurred via the downstream modulation of the TrkB-CREB signaling pathway. Based on these findings, we conclude that ectopic dendrites are likely to be providing functional benefits and that, in RCS rats, miR-125b-5p regulates ectopic neuritogenesis by RBCs through modulation of the BDNF-TrkB-CREB pathway. This suggests that therapies that reduce miR-125b-5p expression could be beneficial in human retinal degenerative disease.

  8. Control rod drive

    SciTech Connect

    Hawke, Basil C.

    1986-01-01

    A control rod drive uses gravitational forces to insert one or more control rods upwardly into a reactor core from beneath the reactor core under emergency conditions. The preferred control rod drive includes a vertically movable weight and a mechanism operatively associating the weight with the control rod so that downward movement of the weight is translated into upward movement of the control rod. The preferred control rod drive further includes an electric motor for driving the control rods under normal conditions, an electrically actuated clutch which automatically disengages the motor during a power failure and a decelerator for bringing the control rod to a controlled stop when it is inserted under emergency conditions into a reactor core.

  9. Piston rod seal

    DOEpatents

    Lindskoug, Stefan

    1984-01-01

    In a piston rod seal of the type comprising a gland through which the piston rod is passed the piston is provided with a sleeve surrounding the piston rod and extending axially so as to axially partly overlap the gland when the piston is in its bottom dead center position.

  10. Light regulation of cGMP metabolism in toad rod outer segments (ROS) deduced from intact photoreceptor and cellfree kinetics

    SciTech Connect

    Dawis, S.M.; Graeff, R.M.; Heyman, R.A.; Walseth, T.F.; Butz, E.A.

    1987-05-01

    The rate of cGMP hydrolysis by phosphodiesterase (PDE) in intact ROS, monitored in dark-adapted isolated toad retina by the rate of /sup 18/O appearance in guanine nucleotide ..cap alpha..-phosphoryls, is 1/360th of that observed in disrupted ROS at a substrate concentration equivalent to the total (cGMP) in ROS. Low to moderate photic stimuli increase this cGMP hydrolytic rate up to 10-fold in intact ROS with little or no change in total (cGMP). G-protein activation determined in intact ROS by the fraction of GDP labeled with /sup 18/O corresponds with light-related increases in cGMP flux. In contrast, relatively high intensities and extended illumination cause attenuation of maximal cGMP hydrolysis with proportionate reductions in total (cGMP). From these observations combined with the effects of activated G-protein on kinetics and cGMP binding of ROS PDE the following model for light-regulation of cGMP metabolism was deduced: cGMP flux in intact ROS is severely restricted in the dark state because approximately 99% of the cGMP is bound to high affinity sites on the non-stimulated form of PDE. This constraint is relieved when activated G-protein converts the cGMP-binding form of PDE to a high K/sub m/ catalytic form. cGMP is then redistributed to a dynamic pool where it is available to PDE catalytic sites and lower affinity allosteric sites. The (cGMP) in the dynamic pool is maintained or further increased or decreased by modulating the activity of an apparently light-sensitive guanylyl cyclase.

  11. CONTROL ROD DRIVE

    DOEpatents

    Chapellier, R.A.; Rogers, I.

    1961-06-27

    Accurate and controlled drive for the control rod is from an electric motor. A hydraulic arrangement is provided to balance a piston against which a control rod is urged by the application of fluid pressure. The electric motor drive of the control rod for normal operation is made through the aforementioned piston. In the event scramming is required, the fluid pressure urging the control rod against the piston is relieved and an opposite fluid pressure is applied. The lack of mechanical connection between the electric motor and control rod facilitates the scramming operation.

  12. Sucker rod construction

    SciTech Connect

    Anderson, R.A.; Goodman, J.L.; Tickle, J.D.; Liskey, A.K.

    1987-03-31

    A sucker rod construction is described comprising: a connector member being formed to define a rod receptacle having a closed axially inner end and an open axially outer end, the rod receptacle having axially spaced, tapered annular surfaces, a cylindrical fiberglass rod having an end having an outer surface being received within the rod receptacle through the outer end and cooperating therewith to define an annular chamber between the outer surface of the end of the rod and the tapered annular surfaces, and a bonding means positioned in the annular chamber for bonding to the outer surface of the end of the rod to confront the tapered annular surfaces, each annular surface having an angle of taper with respect to the outer surface of the fiberglass rod, and each angle of taper being progressively and uniformly less toward the open end by an amount between one and one-half degrees and two degrees, inclusive, and a collet connected to the connector member adjacent the open axially outer end of the rod receptacle and having an axial bore therethrough retaining the end of the rod in coaxial position within the rod receptacle.

  13. CRUCIFORM CONTROL ROD JOINT

    DOEpatents

    Thorp, A.G. II

    1962-08-01

    An invention is described which relates to nuclear reactor control rod components and more particularly to a joint between cruciform control rod members and cruciform control rod follower members. In one embodiment this invention provides interfitting crossed arms at adjacent ends of a control rod and its follower in abutting relation. This holds the members against relative opposite longitudinal movement while a compression member keys the arms against relative opposite rotation around a common axis. Means are also provided for centering the control rod and its follower on a common axis and for selectively releasing the control rod from its follower for the insertion of a replacement of the control rod and reuse of the follower. (AEC)

  14. Nrl is required for rod photoreceptor development.

    PubMed

    Mears, A J; Kondo, M; Swain, P K; Takada, Y; Bush, R A; Saunders, T L; Sieving, P A; Swaroop, A

    2001-12-01

    The protein neural retina leucine zipper (Nrl) is a basic motif-leucine zipper transcription factor that is preferentially expressed in rod photoreceptors. It acts synergistically with Crx to regulate rhodopsin transcription. Missense mutations in human NRL have been associated with autosomal dominant retinitis pigmentosa. Here we report that deletion of Nrl in mice results in the complete loss of rod function and super-normal cone function, mediated by S cones. The photoreceptors in the Nrl-/- retina have cone-like nuclear morphology and short, sparse outer segments with abnormal disks. Analysis of retinal gene expression confirms the apparent functional transformation of rods into S cones in the Nrl-/- retina. On the basis of these findings, we postulate that Nrl acts as a 'molecular switch' during rod-cell development by directly modulating rod-specific genes while simultaneously inhibiting the S-cone pathway through the activation of Nr2e3.

  15. CONTROL ROD DRIVE

    DOEpatents

    Chapellier, R.A.

    1960-05-24

    BS>A drive mechanism was invented for the control rod of a nuclear reactor. Power is provided by an electric motor and an outside source of fluid pressure is utilized in conjunction with the fluid pressure within the reactor to balance the loadings on the motor. The force exerted on the drive mechanism in the direction of scramming the rod is derived from the reactor fluid pressure so that failure of the outside pressure source will cause prompt scramming of the rod.

  16. Pull rod assembly

    DOEpatents

    Cioletti, O.C.

    1988-04-21

    A pull rod assembly comprising a pull rod having three peripheral grooves, a piston device including an adaptor ring and a seal ring, said piston device being mounted on the pull rod by a split ring retainer situated in one groove and extending into an interior groove in the adaptor and a resilient split ring retained in another groove and positioned to engage the piston device and to retain the seal on its adaptor.

  17. FUEL ROD CLUSTERS

    DOEpatents

    Schultz, A.B.

    1959-08-01

    A cluster of nuclear fuel rods and a tubular casing therefor through which a coolant flows in heat-exchange contact with the fuel rods is described. The fuel rcds are held in the casing by virtue of the compressive force exerted between longitudinal ribs of the fuel rcds and internal ribs of the casing or the internal surfaces thereof.

  18. Control rod driveline and grapple

    DOEpatents

    Germer, John H.

    1987-01-01

    A control rod driveline and grapple is disclosed for placement between a control rod drive and a nuclear reactor control rod containing poison for parasitic neutron absorption required for reactor shutdown. The control rod is provided with an enlarged cylindrical handle which terminates in an upwardly extending rod to provide a grapple point for the driveline. The grapple mechanism includes a tension rod which receives the upwardly extending handle and is provided with a lower annular flange. A plurality of preferably six grapple segments surround and grip the control rod handle. Each grapple rod segment grips the flange on the tension rod at an interior upper annular indentation, bears against the enlarged cylindrical handle at an intermediate annulus and captures the upwardly flaring frustum shaped handle at a lower and complementary female segment. The tension rods and grapple segments are surrounded by and encased within a cylinder. The cylinder terminates immediately and outward extending annulus at the lower portion of the grapple segments. Excursion of the tension rod relative to the encasing cylinder causes rod release at the handle by permitting the grapple segments to pivot outwardly and about the annulus on the tension rod so as to open the lower defined frustum shaped annulus and drop the rod. Relative movement between the tension rod and cylinder can occur either due to electromagnetic release of the tension rod within defined limits of travel or differential thermal expansion as between the tension rod and cylinder as where the reactor exceeds design thermal limits.

  19. Trunnion Rod Microcrack Detection

    DTIC Science & Technology

    2013-08-01

    Engineers needs reliable non-destructive testing (NDT) methods that are rapid, robust, and capable of detecting and quantifying defects , as well as...Robustness is required to handle the significant variations in design, construction, and field conditions that are known to exist. Defect detection and...constructed to help contain failing rods. It is not known if the defect growth and resulting rod failure rate will stay at its relatively low number of

  20. Rod Contributions to Color Perception: Linear with Rod Contrast

    PubMed Central

    Cao, Dingcai; Pokorny, Joel; Smith, Vivianne C.; Zele, Andrew J.

    2008-01-01

    At mesopic light levels, an incremental change in rod activation causes changes in color appearance. In this study, we investigated how rod mediated changes in color perception varied as a function of the magnitude of the rod contrast. Rod-mediated changes in color appearance were assessed by matching them with cone-mediated color changes. A two-channel four-primary colorimeter allowed independent control of the rods and each of the L-, M- and S-cone photoreceptor types. At all light levels, rod contributions to inferred PC, KC and MC pathway mediated vision were linearly related to the rod incremental contrast. This linear relationship could be described by a model based on primate ganglion cell responses with the assumption that rod signals were conveyed via rod-cone gap junctions at mesopic light levels. PMID:18561973

  1. Rod photoreceptor-specific gene expression in human retinoblastoma cells.

    PubMed Central

    Di Polo, A; Farber, D B

    1995-01-01

    Retinoblastoma cells in culture have previously been shown to express cone-specific genes but not their rod counterparts. We have detected the messages for the rod alpha, beta, and gamma subunits of cGMP phosphodiesterase (PDE), the rod alpha subunit of transducin, rod opsin, and the cone alpha' subunit of PDE in RNA of human Y-79 retinoblastoma cells by reverse transcription-PCR. Quantitative analysis of the mRNAs for the rod alpha and cone alpha' PDE subunits revealed that they were expressed at comparable levels; however, the transcript encoding the rod beta PDE subunit was 10 times more abundant in these cells. Northern hybridization analysis of Y-79 cell RNA confirmed the presence of the transcripts for rod and cone PDE catalytic subunits. To test whether the transcriptional machinery required for the expression of rod-specific genes was endogenous in Y-79 retinoblastoma cells, cultures were transfected with a construct containing the promoter region of the rod beta PDE subunit gene attached to the firefly luciferase reporter vector. Significant levels of reporter enzyme activity were observed in the cell lysates. Our results demonstrate that the Y-79 retinoblastoma cell line is a good model system for the study of transcriptional regulation of rod-specific genes. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:7732024

  2. 49 CFR 236.794 - Rod, up-and-down.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Rod, up-and-down. 236.794 Section 236.794 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., up-and-down. A rod used for connecting the semaphore arm to the operating mechanism of a signal....

  3. 49 CFR 236.794 - Rod, up-and-down.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Rod, up-and-down. 236.794 Section 236.794 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., up-and-down. A rod used for connecting the semaphore arm to the operating mechanism of a signal....

  4. 49 CFR 236.794 - Rod, up-and-down.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Rod, up-and-down. 236.794 Section 236.794 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., up-and-down. A rod used for connecting the semaphore arm to the operating mechanism of a signal....

  5. 49 CFR 236.794 - Rod, up-and-down.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Rod, up-and-down. 236.794 Section 236.794 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., up-and-down. A rod used for connecting the semaphore arm to the operating mechanism of a signal....

  6. 49 CFR 236.794 - Rod, up-and-down.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Rod, up-and-down. 236.794 Section 236.794 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., up-and-down. A rod used for connecting the semaphore arm to the operating mechanism of a signal....

  7. 49 CFR 236.793 - Rod, lock.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF..., attached to the front rod or lug of a switch, movable-point frog or derail, through which a locking plunger may extend when the switch points or derail are in the normal or reverse position....

  8. 49 CFR 236.793 - Rod, lock.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF..., attached to the front rod or lug of a switch, movable-point frog or derail, through which a locking plunger may extend when the switch points or derail are in the normal or reverse position....

  9. Piston rod seal for a Stirling engine

    SciTech Connect

    Shapiro, Wilbur

    1984-01-01

    In a piston rod seal for a Stirling engine, a hydrostatic bearing and differential pressure regulating valve are utilized to provide for a low pressure differential across a rubbing seal between the hydrogen and oil so as to reduce wear on the seal.

  10. Intramedullary rodding in osteogenesis imperfecta.

    PubMed

    Mulpuri, K; Joseph, B

    2000-01-01

    The results of intramedullary rodding of long bones of 16 children with osteogenesis imperfecta, over a 10-year period, were analyzed. Sheffield elongating rods or non-elongating rods were used. The frequency of fractures was dramatically reduced after implantation of either type of rod, and the ambulatory status improved in all instances. The results were significantly better after Sheffield rodding with regard to the frequency of complications requiring reoperations and the longevity of the rods. Migration of the rods, encountered frequently, appears to be related to improper placement of the rods in the bone. It seems likely that if care is taken to ensure precise placement of a rod of appropriate size, several of these complications may be avoided.

  11. Carbon rod furnace infrared source

    NASA Technical Reports Server (NTRS)

    Boyd, W. J.; Jennings, D. E.; Blass, W. E.; Gailar, N. M.

    1974-01-01

    A carbon rod furnace infrared source has been built and has proven to be a reliable and trouble-free source despite the high rod temperature of 2500 K. The furnace offers several advantages over previous furnaces. These include an increase in usable rod length to 6.35 cm, extended rod life, and a fully automated power supply for the furnace. Construction and operational details are discussed.

  12. Anchor for Fiberglas Guy Rod

    NASA Technical Reports Server (NTRS)

    Wilson, A. H.

    1982-01-01

    Solution to problem of anchoring fiberglas guy rods to install nut with threads on outer circumference, followed by aluminum sleeve. Sleeve has opening oval at upper and round at bottom end. End of rod is split so fiberglas wedge can be inserted to form V-shaped end. Spread end of rod fits into tapered hole in sleeve and threaded aluminum coupling is put over rod and sleeve.

  13. REACTOR CONTROL ROD OPERATING SYSTEM

    DOEpatents

    Miller, G.

    1961-12-12

    A nuclear reactor control rod mechanism is designed which mechanically moves the control rods into and out of the core under normal conditions but rapidly forces the control rods into the core by catapultic action in the event of an emergency. (AEC)

  14. Learning with Rods: One Account.

    ERIC Educational Resources Information Center

    Cherry, Donald Esha

    This paper discusses one English as a Second Language (ESL) teacher's attempts to use cuisenaire rods as a language learning tool. Cuisenaire rods (sometimes called algebricks) vary in size from 1 x 1 x 10 centimeter sticks to 1 x 1 x 1 centimeter cubes, with each of the 10 sizes a different color. Although such rods have been used to teach…

  15. Circadian dynamics of the cone-rod homeobox (CRX) transcription factor in the rat pineal gland and its role in regulation of arylalkylamine N-acetyltransferase (AANAT).

    PubMed

    Rohde, Kristian; Rovsing, Louise; Ho, Anthony K; Møller, Morten; Rath, Martin F

    2014-08-01

    The cone-rod homeobox (Crx) gene encodes a transcription factor in the retina and pineal gland. Crx deficiency influences the pineal transcriptome, including a reduced expression of arylalkylamine N-acetyltransferase (Aanat), a key enzyme in nocturnal pineal melatonin production. However, previous functional studies on pineal Crx have been performed in melatonin-deficient mice. In this study, we have investigated the role of Crx in the melatonin-proficient rat pineal gland. The current study shows that pineal Crx transcript levels exhibit a circadian rhythm with a peak in the middle of the night, which is transferred into daily changes in CRX protein. The study further shows that the sympathetic innervation of the pineal gland controls the Crx rhythm. By use of adenovirus-mediated short hairpin RNA gene knockdown targeting Crx mRNA in primary rat pinealocyte cell culture, we here show that intact levels of Crx mRNA are required to obtain high levels of Aanat expression, whereas overexpression of Crx induces Aanat transcription in vitro. This regulatory function of Crx is further supported by circadian analysis of Aanat in the pineal gland of the Crx-knockout mouse. Our data indicate that the rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat expression by inducing nighttime expression of this enzyme, thus facilitating nocturnal melatonin synthesis in addition to its role in ensuring a correct tissue distribution of Aanat expression.

  16. SAFETY SYSTEM FOR CONTROL ROD

    DOEpatents

    Paget, J.A.

    1963-05-14

    A structure for monitoring the structural continuity of a control rod foi a neutron reactor is presented. A electric conductor readily breakable under mechanical stress is fastened along the length of the control rod at a plurality of positions and forms a closed circuit with remote electrical components responsive to an open circuit. A portion of the conductor between the control rod and said components is helically wound to allow free and normally unrestricted movement of the segment of conductor secured to the control rod relative to the remote components. Any break in the circuit is indicative of control rod breakage. (AEC)

  17. Locked-wrap fuel rod

    DOEpatents

    Kaplan, Samuel; Chertock, Alan J.; Punches, James R.

    1977-01-01

    A method for spacing fast reactor fuel rods using a wire wrapper improved by orienting the wire-wrapped fuel rods in a unique manner which introduces desirable performance characteristics not attainable by previous wire-wrapped designs. Use of this method in a liquid metal fast breeder reactor results in: (a) improved mechanical performance, (b) improved rod-to-rod contact, (c) reduced steel volume, and (d) improved thermal-hydraulic performance. The method produces a "locked wrap" design which tends to lock the rods together at each of the wire cluster locations.

  18. Safety rod latch inspection

    SciTech Connect

    Leader, D.R.

    1992-02-01

    During an attempt to raise control rods from the 100 K reactor in December, one rod could not be withdrawn. Subsequent investigation revealed that a small button'' in the latch mechanism had broken off of the lock plunger'' and was wedged in a position that prevented rod withdrawal. Concern that this failure may have resulted from corrosion or some other metallurgical problem resulted in a request that SRL examine six typical latch mechanisms from the 100 L reactor by use of radiography and metallography. During the examination of the L-Area latches, a failed latch mechanism from the 100 K reactor was added to the investigation. Fourteen latches that had a history of problems were removed from K-Area and sent to SRL for inclusion in this study the week after the original seven assemblies were examined, bringing the total of latch assemblies discussed in this report to twenty one. Results of the examination of the K-Area latch that initiated this study is not included in this report.

  19. Safety rod latch inspection

    SciTech Connect

    Leader, D.R.

    1992-02-01

    During an attempt to raise control rods from the 100 K reactor in December, one rod could not be withdrawn. Subsequent investigation revealed that a small ``button`` in the latch mechanism had broken off of the ``lock plunger`` and was wedged in a position that prevented rod withdrawal. Concern that this failure may have resulted from corrosion or some other metallurgical problem resulted in a request that SRL examine six typical latch mechanisms from the 100 L reactor by use of radiography and metallography. During the examination of the L-Area latches, a failed latch mechanism from the 100 K reactor was added to the investigation. Fourteen latches that had a history of problems were removed from K-Area and sent to SRL for inclusion in this study the week after the original seven assemblies were examined, bringing the total of latch assemblies discussed in this report to twenty one. Results of the examination of the K-Area latch that initiated this study is not included in this report.

  20. Mitogen-associated protein kinase- and protein kinase A-dependent regulation of rhodopsin promoter expression in zebrafish rod photoreceptor cells.

    PubMed

    Yu, Chuan-Jiang; Gao, Yan; Willis, Callie L; Li, Ping; Tiano, Joseph P; Nakamura, Paul A; Hyde, David R; Li, Lei

    2007-02-15

    Mitogen-associated protein kinase (MAPK)- and protein kinase A (PKA)-dependent signal transductions play important roles in the regulation of gene expression. Both MAPK and PKA pathways can be activated by light exposure. In this study, we investigated the effect of light on MAPK and PKA signal transduction and their roles in the regulation of rhodopsin promoter expression by using transgenic zebrafish [Tg(rhod::GFP)]. The Tg(rhod::GFP) fish express short half-life GFP that is under the transcriptional control of the zebrafish rhodopsin promoter and can therefore be used for in vivo studies of rhodopsin gene transcription in live cells. Blue light plays a role in the regulation of rhodopsin promoter expression via an MAPK-mediated signal transduction cascade. Blue light excites cryptochromes (CRY), which activate the downstream PKC-dependent MAPK signal pathway. White light, on the other hand, regulates rhodopsin promoter expression via a G-protein-coupled cAMP-dependent PKA pathway. White light promotes dopamine release in the retina, which activates dopamine receptors and the downstream PKA pathway. Blocking MAPK signaling diminishes the blue light-induced increases in rhodopsin promoter expression, but this treatment has no effect on white light-mediated rhodopsin promoter expression. Conversely, blocking the PKA pathway diminishes the white light-induced rhodopsin promoter expression but does not affect rhodopsin promoter expression regulated by blue light. Together, the data suggest that MAPK and PKA regulate rhodopsin transcription through parallel signal transduction pathways.

  1. Autophagy supports survival and phototransduction protein levels in rod photoreceptors

    PubMed Central

    Zhou, Z; Doggett, T A; Sene, A; Apte, R S; Ferguson, T A

    2015-01-01

    Damage and loss of the postmitotic photoreceptors is a leading cause of blindness in many diseases of the eye. Although the mechanisms of photoreceptor death have been extensively studied, few studies have addressed mechanisms that help sustain these non-replicating neurons for the life of an organism. Autophagy is an intracellular pathway where cytoplasmic constituents are delivered to the lysosomal pathway for degradation. It is not only a major pathway activated in response to cellular stress, but is also important for cytoplasmic turnover and to supply the structural and energy needs of cells. We examined the importance of autophagy in photoreceptors by deleting the essential autophagy gene Atg5 specifically in rods. Loss of autophagy led to progressive degeneration of rod photoreceptors beginning at 8 weeks of age such that by 44 weeks few rods remained. Cone photoreceptor numbers were only slightly diminished following rod degeneration but their function was significantly decreased. Rod cell death was apoptotic but was not dependent on daily light exposure or accelerated by intense light. Although the light-regulated translocation of the phototransduction proteins arrestin and transducin were unaffected in rods lacking autophagy, Atg5-deficient rods accumulated transducin-α as they degenerated suggesting autophagy might regulate the level of this protein. This was confirmed when the light-induced decrease in transducin was abolished in Atg5-deficient rods and the inhibition of autophagy in retinal explants cultures prevented its degradation. These results demonstrate that basal autophagy is essential to the long-term health of rod photoreceptors and a critical process for maintaining optimal levels of the phototransduction protein transducin-α. As the lack of autophagy is associated with retinal degeneration and altered phototransduction protein degradation in the absence of harmful gene products, this process may be a viable therapeutic target where rod

  2. Fiber optic laser rod

    DOEpatents

    Erickson, G.F.

    1988-04-13

    A laser rod is formed from a plurality of optical fibers, each forming an individual laser. Synchronization of the individual fiber lasers is obtained by evanescent wave coupling between adjacent optical fiber cores. The fiber cores are dye-doped and spaced at a distance appropriate for evanescent wave coupling at the wavelength of the selected dye. An interstitial material having an index of refraction lower than that of the fiber core provides the optical isolation for effective lasing action while maintaining the cores at the appropriate coupling distance. 2 figs.

  3. Cone rod dystrophies

    PubMed Central

    Hamel, Christian P

    2007-01-01

    Cone rod dystrophies (CRDs) (prevalence 1/40,000) are inherited retinal dystrophies that belong to the group of pigmentary retinopathies. CRDs are characterized by retinal pigment deposits visible on fundus examination, predominantly localized to the macular region. In contrast to typical retinitis pigmentosa (RP), also called the rod cone dystrophies (RCDs) resulting from the primary loss in rod photoreceptors and later followed by the secondary loss in cone photoreceptors, CRDs reflect the opposite sequence of events. CRD is characterized by primary cone involvement, or, sometimes, by concomitant loss of both cones and rods that explains the predominant symptoms of CRDs: decreased visual acuity, color vision defects, photoaversion and decreased sensitivity in the central visual field, later followed by progressive loss in peripheral vision and night blindness. The clinical course of CRDs is generally more severe and rapid than that of RCDs, leading to earlier legal blindness and disability. At end stage, however, CRDs do not differ from RCDs. CRDs are most frequently non syndromic, but they may also be part of several syndromes, such as Bardet Biedl syndrome and Spinocerebellar Ataxia Type 7 (SCA7). Non syndromic CRDs are genetically heterogeneous (ten cloned genes and three loci have been identified so far). The four major causative genes involved in the pathogenesis of CRDs are ABCA4 (which causes Stargardt disease and also 30 to 60% of autosomal recessive CRDs), CRX and GUCY2D (which are responsible for many reported cases of autosomal dominant CRDs), and RPGR (which causes about 2/3 of X-linked RP and also an undetermined percentage of X-linked CRDs). It is likely that highly deleterious mutations in genes that otherwise cause RP or macular dystrophy may also lead to CRDs. The diagnosis of CRDs is based on clinical history, fundus examination and electroretinogram. Molecular diagnosis can be made for some genes, genetic counseling is always advised. Currently

  4. Reactor control rod timing system

    DOEpatents

    Wu, Peter T. K.

    1982-01-01

    A fluid driven jet-edge whistle timing system for control rods of a nuclear reactor for producing real-time detection of the timing of each control rod in its scram operation. An important parameter in reactor safety, particularly for liquid metal fast breeder reactors (LMFBR), is the time deviation between the time the control rod is released and the time the rod actually reaches the down position. The whistle has a nearly pure tone signal with center frequency (above 100 kHz) far above the frequency band in which the energy of the background noise is concentrated. Each control rod can be fitted with a whistle with a different frequency so that there is no ambiguity in differentiating the signal from each control rod.

  5. Making Highly Pure Glass Rods

    NASA Technical Reports Server (NTRS)

    Naumann, R. J.

    1986-01-01

    Proposed quasi-containerless method for making glass rods or fibers minimizes contact between processing equipment and product. Method allows greater range of product sizes and shapes than achieved in experiments on containerless processing. Molten zone established in polycrystalline rod. Furnace sections separated, and glass rod solidifies between them. Clamp supports solid glass as it grows in length. Pulling clamp rapidly away from melt draws glass fiber. Fiber diameter controlled by adjustment of pulling rate.

  6. Piston and connecting rod assembly

    NASA Technical Reports Server (NTRS)

    Brogdon, James William (Inventor); Gill, David Keith (Inventor); Chatten, John K. (Inventor)

    2001-01-01

    A piston and connecting rod assembly includes a piston crown, a piston skirt, a connecting rod, and a bearing insert. The piston skirt is a component separate from the piston crown and is connected to the piston crown to provide a piston body. The bearing insert is a component separate from the piston crown and the piston skirt and is fixedly disposed within the piston body. A bearing surface of a connecting rod contacts the bearing insert to thereby movably associate the connecting rod and the piston body.

  7. Active Brownian rods

    NASA Astrophysics Data System (ADS)

    Peruani, Fernando

    2016-11-01

    Bacteria, chemically-driven rods, and motility assays are examples of active (i.e. self-propelled) Brownian rods (ABR). The physics of ABR, despite their ubiquity in experimental systems, remains still poorly understood. Here, we review the large-scale properties of collections of ABR moving in a dissipative medium. We address the problem by presenting three different models, of decreasing complexity, which we refer to as model I, II, and III, respectively. Comparing model I, II, and III, we disentangle the role of activity and interactions. In particular, we learn that in two dimensions by ignoring steric or volume exclusion effects, large-scale nematic order seems to be possible, while steric interactions prevent the formation of orientational order at large scales. The macroscopic behavior of ABR results from the interplay between active stresses and local alignment. ABR exhibit, depending on where we locate ourselves in parameter space, a zoology of macroscopic patterns that ranges from polar and nematic bands to dynamic aggregates.

  8. Control of Rod-Rod Interactions in Poly(3-alkylthiophenes)

    NASA Astrophysics Data System (ADS)

    Ho, Victor; Boudouris, Bryan W.; Segalman, Rachel A.

    2010-03-01

    Poly(3-hexylthiophene) is a commonly used semiconducting polymer because of its relatively high charge transport ability, low band gap, and solution processiblity. Strong intermolecular interactions lead to the formation of nanofibers during crystallization, which prevents long-range microstructural ordering. We show rod-rod interactions, parameterized by the Maier-Saupe parameter, can be controlled by rational polythiophene side chain design. Effects of side chain passivation are evidenced by a depressed melting temperature and the presence of a liquid crystalline region. Additionally, the Maier-Saupe parameters are estimated for poly(3-dodecylthiophene) and poly(3-ethylhexylthiophene); the relative magnitudes of each are related to the interchain spacings obtained by x-ray diffraction experiments. The systematic tuning of the rod-rod interactions in polythiophenes allows for manipulation of the ratio of Maier-Saupe to the Flory-Huggins parameter, a crucial value in obtaining long-range order in rod-coil block copolymer morphologies.

  9. Rod Microglia: A Morphological Definition

    PubMed Central

    Taylor, Samuel E.; Morganti-Kossmann, Cristina

    2014-01-01

    Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however neither a function nor specific morphology has been defined. Historically, rod microglia have been described intermittently as cells with a sausage-shaped soma and long, thin processes, which align adjacent to neurons. More recently, our group has described rod microglia aligning end-to-end with one another to form trains adjacent to neuronal processes. Confusion in the literature regarding rod microglia arises from some reports referring to the sausage-shaped cell body, while ignoring the spatial distribution of processes. Here, we systematically define the morphological characteristics of rod microglia that form after diffuse brain injury in the rat, which differ morphologically from the spurious rod microglia found in uninjured sham. Rod microglia in the diffuse-injured rat brain show a ratio of 1.79±0.03 cell length∶cell width at day 1 post-injury, which increases to 3.35±0.05 at day 7, compared to sham (1.17±0.02). The soma length∶width differs only at day 7 post-injury (2.92±0.07 length∶width), compared to sham (2.49±0.05). Further analysis indicated that rod microglia may not elongate in cell length but rather narrow in cell width, and retract planar (side) processes. These morphological characteristics serve as a tool for distinguishing rod microglia from other morphologies. The function of rod microglia remains enigmatic; based on morphology we propose origins and functions for rod microglia after acute neurological insult, which may provide biomarkers or therapeutic targets. PMID:24830807

  10. Spherical Joint Piston and Connecting Rod Developed

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Under an interagency agreement with the Department of Energy, the NASA Lewis Research Center manages a Heavy-Duty Diesel Engine Technology (HDET) research program. The overall program objectives are to reduce fuel consumption through increased engine efficiency, reduce engine exhaust emissions, and provide options for the use of alternative fuels. The program is administered with a balance of research contracts, university research grants, and focused in-house research. The Cummins Engine Company participates in the HDET program under a cost-sharing research contract. Cummins is researching and developing in-cylinder component technologies for heavy-duty diesel engines. An objective of the Cummins research is to develop technologies for a low-emissions, 55-percent thermal efficiency (LE-55) engine. The best current-production engines in this class achieve about 46-percent thermal efficiency. Federal emissions regulations are driving this technology. Regulations for heavy duty diesel engines were tightened in 1994, more demanding emissions regulations are scheduled for 1998, and another step is planned for 2002. The LE-55 engine emissions goal is set at half of the 1998 regulation level and is consistent with plans for 2002 emissions regulations. LE-55 engine design requirements to meet the efficiency target dictate a need to operate at higher peak cylinder pressures. A key technology being developed and evaluated under the Cummins Engine Company LE-55 engine concept is the spherical joint piston and connecting rod. Unlike conventional piston and connecting rod arrangements which are joined by a pin forming a hinged joint, the spherical joint piston and connecting rod use a ball-and-socket joint. The ball-and-socket arrangement enables the piston to have an axisymmetric design allowing rotation within the cylinder. The potential benefits of piston symmetry and rotation are reduced scuffing, improved piston ring sealing, improved lubrication, mechanical and thermal

  11. Cuisenaire Rods Go to College.

    ERIC Educational Resources Information Center

    Chinn, Phyllis; And Others

    1992-01-01

    Presents examples of questions and answers arising from a hands-on and exploratory approach to discrete mathematics using cuisenaire rods. Combinatorial questions about trains formed of cuisenaire rods provide the setting for discovering numerical patterns by experimentation and organizing the results using induction and successive differences.…

  12. Sucker rod pump

    SciTech Connect

    Brewer, J.R.

    1992-04-14

    This patent describes a subsurface well pump, it comprises: a working barrel; a plunger which reciprocates along the vertical axis within the working barrel between an upper and lower position; a rod connected to the plunger and extending to a means for providing reciprocating force; a well string extending from the top of the working barrel to the surface; an outlet check valve which permits flow to exit the working barrel into the well string and does not permit flow to exit the well string into the working barrel; and an inlet check valve which permits flow into the working barrel from outside of the subsurface pump, the inlet check valve being above the top position of the plunger, the inlet check valve having a cross sectional flow area about equal to or greater than the horizontal cross sectional area of the working barrel, and the inlet check valve being a hinged flapper valve.

  13. Experiments with a falling rod

    NASA Astrophysics Data System (ADS)

    Oliveira, Vitor

    2016-02-01

    We study the motion of a uniform thin rod released from rest, with the bottom end initially in contact with a horizontal surface. Our focus here is the motion of the bottom end as the rod falls. For small angles of release with respect to the horizontal, the rod falls without the bottom end slipping. For larger angles, the slipping direction depends on the static friction coefficient between the rod and the horizontal surface. Small friction coefficients cause the end to slip initially in one direction and then in the other, while for high coefficients, the end slips in one direction only. For intermediate values, depending on the angle of release, both situations can occur. We find the initial slipping direction to depend on a relation between the angle at which the rod slips, and a critical angle at which the frictional force vanishes. Comparison between experimental data and numerical simulations shows good agreement.

  14. Topological mixing with ghost rods.

    PubMed

    Gouillart, Emmanuelle; Thiffeault, Jean-Luc; Finn, Matthew D

    2006-03-01

    Topological chaos relies on the periodic motion of obstacles in a two-dimensional flow in order to form nontrivial braids. This motion generates exponential stretching of material lines, and hence efficient mixing. Boyland, Aref, and Stremler [J. Fluid Mech. 403, 277 (2000)] have studied a specific periodic motion of rods that exhibits topological chaos in a viscous fluid. We show that it is possible to extend their work to cases where the motion of the stirring rods is topologically trivial by considering the dynamics of special periodic points that we call "ghost rods", because they play a similar role to stirring rods. The ghost rods framework provides a new technique for quantifying chaos and gives insight into the mechanisms that produce chaos and mixing. Numerical simulations for Stokes flow support our results.

  15. Bleaching of mouse rods: microspectrophotometry and suction-electrode recording

    PubMed Central

    Nymark, S; Frederiksen, R; Woodruff, M L; Cornwall, M C; Fain, G L

    2012-01-01

    When a substantial fraction of rhodopsin in a rod photoreceptor is exposed to bright light, the rod is desensitized by a process known as bleaching adaptation. Experiments on isolated photoreceptors in amphibians have revealed many of the features of bleaching adaptation, but such experiments have not so far been possible in mammals. We now describe a method for making microspectrophotometric measurements of pigment concentration and suction-electrode recording of electrical responses over a wide range of bleaching exposures from isolated mouse rods or pieces of mouse retina. We show that if pigment is bleached at a low rate in the presence of bovine serum albumin (BSA), and intermediate photoproducts are allowed to decay, mouse rods are stably desensitized; subsequent treatment with exogenous 11-cis retinal results in pigment regeneration and substantial recovery of sensitivity to the dark-adapted value. Stably bleached wild-type (WT) rods show a decrease in circulating current and acceleration of the time course of decay, much as in steady background light; similar effects are seen in guanylyl cyclase-activating protein knockout (GCAPs−/−) rods, indicating that regulation of guanylyl cyclase is not necessary for at least a part of the adaptation produced by bleaching. Our experiments demonstrate that in mammalian rods, as in amphibian rods, steady-state desensitization after bleaching is produced by two components: (1) a reduction in the probability of photon absorption produced by a decrease in rhodopsin concentration; and (2) an equivalent background light whose intensity is proportional to the fraction of bleached pigment, and which adapts the rod like real background light. These two mechanisms together fully account for the ‘log-linear’ relationship in mammalian retina between sensitivity and per cent bleach, which can be measured in the steady state following exposure to bright light. Our methods will now make possible an examination of bleaching

  16. Eulerian formulation of elastic rods

    NASA Astrophysics Data System (ADS)

    Huynen, Alexandre; Detournay, Emmanuel; Denoël, Vincent

    2016-06-01

    In numerous biological, medical and engineering applications, elastic rods are constrained to deform inside or around tube-like surfaces. To solve efficiently this class of problems, the equations governing the deflection of elastic rods are reformulated within the Eulerian framework of this generic tubular constraint defined as a perfectly stiff normal ringed surface. This reformulation hinges on describing the rod-deformed configuration by means of its relative position with respect to a reference curve, defined as the axis or spine curve of the constraint, and on restating the rod local equilibrium in terms of the curvilinear coordinate parametrizing this curve. Associated with a segmentation strategy, which partitions the global problem into a sequence of rod segments either in continuous contact with the constraint or free of contact (except for their extremities), this re-parametrization not only trivializes the detection of new contacts but also transforms these free boundary problems into classic two-points boundary-value problems and suppresses the isoperimetric constraints resulting from the imposition of the rod position at the extremities of each rod segment.

  17. The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control

    PubMed Central

    Athanasiou, Dimitra; Bevilacqua, Dalila; Aguila, Monica; McCulley, Caroline; Kanuga, Naheed; Iwawaki, Takao; Paul Chapple, J.; Cheetham, Michael E.

    2014-01-01

    Mutations in rhodopsin, the light-sensitive protein of rod cells, are the most common cause of autosomal dominant retinitis pigmentosa (ADRP). Many rod opsin mutations, such as P23H, lead to misfolding of rod opsin with detrimental effects on photoreceptor function and viability. Misfolded P23H rod opsin and other mutations in the intradiscal domain are characterized by the formation of an incorrect disulphide bond between C185 and C187, as opposed to the correct and highly conserved C110–C187 disulphide bond. Therefore, we tested the hypothesis that incorrect disulphide bond formation might be a factor that affects the biogenesis of rod opsin by studying wild-type (WT) or P23H rod opsin in combination with amino acid substitutions that prevent the formation of incorrect disulphide bonds involving C185. These mutants had altered traffic dynamics, suggesting a requirement for regulation of disulphide bond formation/reduction during rod opsin biogenesis. Here, we show that the BiP co-chaperone and reductase protein ERdj5 (DNAJC10) regulates this process. ERdj5 overexpression promoted the degradation, improved the endoplasmic reticulum mobility and prevented the aggregation of P23H rod opsin. ERdj5 reduction by shRNA delayed rod opsin degradation and promoted aggregation. The reductase and co-chaperone activity of ERdj5 were both required for these effects on P23H rod opsin. Furthermore, mutations in these functional domains acted as dominant negatives that affected WT rod opsin biogenesis. Collectively, these data identify ERdj5 as a member of the proteostasis network that regulates rod opsin biogenesis and supports a role for disulphide bond formation/reduction in rod opsin biogenesis and disease. PMID:25055872

  18. The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.

    PubMed

    Athanasiou, Dimitra; Bevilacqua, Dalila; Aguila, Monica; McCulley, Caroline; Kanuga, Naheed; Iwawaki, Takao; Chapple, J Paul; Cheetham, Michael E

    2014-12-15

    Mutations in rhodopsin, the light-sensitive protein of rod cells, are the most common cause of autosomal dominant retinitis pigmentosa (ADRP). Many rod opsin mutations, such as P23H, lead to misfolding of rod opsin with detrimental effects on photoreceptor function and viability. Misfolded P23H rod opsin and other mutations in the intradiscal domain are characterized by the formation of an incorrect disulphide bond between C185 and C187, as opposed to the correct and highly conserved C110-C187 disulphide bond. Therefore, we tested the hypothesis that incorrect disulphide bond formation might be a factor that affects the biogenesis of rod opsin by studying wild-type (WT) or P23H rod opsin in combination with amino acid substitutions that prevent the formation of incorrect disulphide bonds involving C185. These mutants had altered traffic dynamics, suggesting a requirement for regulation of disulphide bond formation/reduction during rod opsin biogenesis. Here, we show that the BiP co-chaperone and reductase protein ERdj5 (DNAJC10) regulates this process. ERdj5 overexpression promoted the degradation, improved the endoplasmic reticulum mobility and prevented the aggregation of P23H rod opsin. ERdj5 reduction by shRNA delayed rod opsin degradation and promoted aggregation. The reductase and co-chaperone activity of ERdj5 were both required for these effects on P23H rod opsin. Furthermore, mutations in these functional domains acted as dominant negatives that affected WT rod opsin biogenesis. Collectively, these data identify ERdj5 as a member of the proteostasis network that regulates rod opsin biogenesis and supports a role for disulphide bond formation/reduction in rod opsin biogenesis and disease.

  19. Topological mixing with ghost rods

    NASA Astrophysics Data System (ADS)

    Gouillart, Emmanuelle; Thiffeault, Jean-Luc; Finn, Matthew D.

    2006-03-01

    Topological chaos relies on the periodic motion of obstacles in a two-dimensional flow in order to form nontrivial braids. This motion generates exponential stretching of material lines, and hence efficient mixing. Boyland, Aref, and Stremler [J. Fluid Mech. 403, 277 (2000)] have studied a specific periodic motion of rods that exhibits topological chaos in a viscous fluid. We show that it is possible to extend their work to cases where the motion of the stirring rods is topologically trivial by considering the dynamics of special periodic points that we call “ghost rods”, because they play a similar role to stirring rods. The ghost rods framework provides a new technique for quantifying chaos and gives insight into the mechanisms that produce chaos and mixing. Numerical simulations for Stokes flow support our results.

  20. Report on the evaluation of the tritium producing burnable absorber rod lead test assembly. Revision 1

    SciTech Connect

    1997-03-01

    This report describes the design and fabrication requirements for a tritium-producing burnable absorber rod lead test assembly and evaluates the safety issues associated with tritium-producing burnable absorber rod irradiation on the operation of a commercial light water reactor. The report provides an evaluation of the tritium-producing burnable absorber rod design and concludes that irradiation can be performed within U.S. Nuclear Regulatory Commission regulations applicable to a commercial pressurized light water reactor.

  1. Hydrothermal synthesis of hydroxyapatite rods

    NASA Astrophysics Data System (ADS)

    Zhang, Xing; Vecchio, Kenneth S.

    2007-10-01

    Hydroxyapatite (HAP) rods were synthesized from dicalcium phosphate anhydrous (CaHPO 4, DCPA) and calcium carbonate (CaCO 3) by the hydrothermal method from 120 to 180 °C. Both cuttlebone (aragonite polymorph of CaCO 3) and CaCO 3 chemical (calcite polymorph of CaCO 3) were used as CaCO 3 sources. The nucleation and growth of HAP rods mainly occurred on DCPA particles, while some HAP rods also grew from aragonite particles. The nucleation and growth of β-tricalcium phosphate (β-TCP) particles on the surface of calcite particles were observed at the beginning of the reaction of DCPA and calcite, and some HAP rods were also found to grow out of β-TCP particles. After the hydrothermal reaction at 140 °C for 24 h, most products are HAP with a small amount of β-TCP synthesized as a byproduct. The HAP rods synthesized were ˜200 nm in width and several microns in length. The reaction mechanism and growth process of HAP rods are discussed.

  2. Nuclear design of Helical Cruciform Fuel rods

    SciTech Connect

    Shirvan, K.; Kazimi, M. S.

    2012-07-01

    In order to increase the power density of current and new light water reactor designs, the Helical Cruciform Fuel (HCF) rods are proposed. The HCF rods are equivalent to a cylindrical rod, with the fuel in a cruciform shaped, twisted axially. The HCF rods increase the surface area to volume ratio and inter-subchannel mixing behavior due to their cruciform and helical shapes, respectively. In a previous study, the HCF rods have shown the potential to up-rate existing PWRs by 50% and BWRs by 25%. However, HCF rods do display different neutronics modeling and performance. The cruciform cross section of HCF rods creates radially asymmetric heat generation and temperature distribution. The nominal HCF rod's beginning of life reactivity is reduced, compared to a cylindrical rod with the same fuel volume, by 500 pcm, due to increase in absorption in cladding. The rotation of these rods accounts for reactivity changes, which depends on the H/HM ratio of the pin cell. The HCF geometry shows large sensitivities to U{sup 235} or gadolinium enrichments compared to a cylindrical geometry. In addition, the gadolinium-containing HCF rods show a stronger effect on neighboring HCF rods than in case of cylindrical rods, depending on the orientation of the HCF rods. The helical geometry of the rods introduces axial shadowing of about 600 pcm, not seen in typical cylindrical rods. (authors)

  3. Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors.

    PubMed

    Swain, P K; Hicks, D; Mears, A J; Apel, I J; Smith, J E; John, S K; Hendrickson, A; Milam, A H; Swaroop, A

    2001-09-28

    NRL, a bZIP transcription factor of the Maf subfamily, interacts with the homeodomain protein CRX and synergistically regulates rhodopsin expression. Here we report that six isoforms of NRL (29-35 kDa) are generated by phosphorylation and expressed specifically in the mammalian retina. The anti-NRL antibody also cross-reacts with a cytosolic 45-kDa protein, which is detected in neuronal tissues but is not encoded by the NRL gene. In both human retinal cell cultures and sections of fetal and adult human retina, NRL is present in the nuclei of developing and mature rods but not cones. We propose that NRL regulates rod photoreceptor-specific gene expression and is involved in rod differentiation.

  4. Direct Evidence for Daily Plasticity of Electrical Coupling between Rod Photoreceptors in the Mammalian Retina

    PubMed Central

    Jin, Nan Ge

    2016-01-01

    Rod photoreceptors are electrically coupled through gap junctions. Coupling is a key determinant of their light response properties, but whether rod electrical coupling is dynamically regulated remains elusive and controversial. Here, we have obtained direct measurements of the conductance between adjacent rods in mouse retina and present evidence that rod electrical coupling strength is dependent on the time of day, the lighting conditions, and the mouse strain. Specifically, we show in CBA/Ca mice that under circadian conditions, the rod junctional conductance has a median value of 98 pS during the subjective day and of 493 pS during the subjective night. In C57BL/6 mice, the median junctional conductance between dark-adapted rods is ∼140 pS, regardless of the time in the circadian cycle. Adaptation to bright light decreases the rod junctional conductance to ∼0 pS, regardless of the time of day or the mouse strain. Together, these results establish the high degree of plasticity of rod electrical coupling over the course of the day. Estimates of the rod coupling strength will provide a foundation for further investigations of rod interactions and the role of rod coupling in the ability of the visual system to anticipate, assimilate, and respond to the daily changes in ambient light intensity. SIGNIFICANCE STATEMENT Many cells in the CNS communicate via gap junctions, or electrical synapses, the regulation of which remains largely unknown. Here, we show that the strength of electrical coupling between rod photoreceptors of the retina is regulated by the time of day and the lighting conditions. This mechanism may help us understand some key aspects of day and night vision as well as some visual malfunctions. PMID:26740659

  5. NEUTRONIC REACTOR CONTROL ROD DRIVE APPARATUS

    DOEpatents

    Oakes, L.C.; Walker, C.S.

    1959-12-15

    ABS>A suspension mechanism between a vertically movable nuclear reactor control rod and a rod extension, which also provides information for the operator or an automatic control signal, is described. A spring connects the rod extension to a drive shift. The extension of the spring indicates whether (1) the rod is at rest on the reactor, (2) the rod and extension are suspended, or (3) the extension alone is suspended, the spring controlling a 3-position electrical switch.

  6. Behavior of Segmented Rods during Penetration

    DTIC Science & Technology

    1990-07-01

    full-scale penetrators which had been swaged 24%. The density of this tungsten alloy was 17.2 Mg/m 3. Gold-alloy penetrators were composed of 92Au-4.9Ag...of behavior. Segmented rods of tungsten alloy always penetrated less than the equivalent unitary rod. Successive rod segments were found to...gold-alloy penetrators because unitary rods of this material surpassed the perform- ance of unitary tungsten -alloy rods, while leaving almost no

  7. The evolution of rod photoreceptors.

    PubMed

    Morshedian, Ala; Fain, Gordon L

    2017-04-05

    Photoreceptors in animals are generally of two kinds: the ciliary or c-type and the rhabdomeric or r-type. Although ciliary photoreceptors are found in many phyla, vertebrates seem to be unique in having two distinct kinds which together span the entire range of vision, from single photons to bright light. We ask why the principal photoreceptors of vertebrates are ciliary and not rhabdomeric, and how rods evolved from less sensitive cone-like photoreceptors to produce our duplex retina. We suggest that the principal advantage of vertebrate ciliary receptors is that they use less ATP than rhabdomeric photoreceptors. This difference may have provided sufficient selection pressure for the development of a completely ciliary eye. Although many of the details of rod evolution are still uncertain, present evidence indicates that (i) rods evolved very early before the split between the jawed and jawless vertebrates, (ii) outer-segment discs make no contribution to rod sensitivity but may have evolved to increase the efficiency of protein renewal, and (iii) evolution of the rod was incremental and multifaceted, produced by the formation of several novel protein isoforms and by changes in protein expression, with no one alteration having more than a few-fold effect on transduction activation or inactivation.This article is part of the themed issue 'Vision in dim light'.

  8. 49 CFR 230.93 - Pistons and piston rods.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Pistons and piston rods. 230.93 Section 230.93 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Steam Locomotives...

  9. 43 CFR 2094.2 - Waiver of 160-rod limitation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Waiver of 160-rod limitation. 2094.2 Section 2094.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SPECIAL LAWS AND RULES...

  10. 43 CFR 2094.2 - Waiver of 160-rod limitation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Waiver of 160-rod limitation. 2094.2 Section 2094.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SPECIAL LAWS AND RULES...

  11. 43 CFR 2094.2 - Waiver of 160-rod limitation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Waiver of 160-rod limitation. 2094.2 Section 2094.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SPECIAL LAWS AND RULES...

  12. 43 CFR 2094.2 - Waiver of 160-rod limitation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Waiver of 160-rod limitation. 2094.2 Section 2094.2 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SPECIAL LAWS AND RULES...

  13. 49 CFR 230.93 - Pistons and piston rods.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Pistons and piston rods. 230.93 Section 230.93 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Steam Locomotives and...

  14. 49 CFR 230.93 - Pistons and piston rods.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Pistons and piston rods. 230.93 Section 230.93 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Steam Locomotives and...

  15. 49 CFR 230.93 - Pistons and piston rods.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Pistons and piston rods. 230.93 Section 230.93 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Steam Locomotives and...

  16. 49 CFR 230.93 - Pistons and piston rods.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Pistons and piston rods. 230.93 Section 230.93 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Steam Locomotives and...

  17. Advanced gray rod control assembly

    DOEpatents

    Drudy, Keith J; Carlson, William R; Conner, Michael E; Goldenfield, Mark; Hone, Michael J; Long, Jr., Carroll J; Parkinson, Jerod; Pomirleanu, Radu O

    2013-09-17

    An advanced gray rod control assembly (GRCA) for a nuclear reactor. The GRCA provides controlled insertion of gray rod assemblies into the reactor, thereby controlling the rate of power produced by the reactor and providing reactivity control at full power. Each gray rod assembly includes an elongated tubular member, a primary neutron-absorber disposed within the tubular member said neutron-absorber comprising an absorber material, preferably tungsten, having a 2200 m/s neutron absorption microscopic capture cross-section of from 10 to 30 barns. An internal support tube can be positioned between the primary absorber and the tubular member as a secondary absorber to enhance neutron absorption, absorber depletion, assembly weight, and assembly heat transfer characteristics.

  18. Stuck fuel rod capping sleeve

    DOEpatents

    Gorscak, Donald A.; Maringo, John J.; Nilsen, Roy J.

    1988-01-01

    A stuck fuel rod capping sleeve to be used during derodding of spent fuel assemblies if a fuel rod becomes stuck in a partially withdrawn position and, thus, has to be severed. The capping sleeve has an inner sleeve made of a lower work hardening highly ductile material (e.g., Inconel 600) and an outer sleeve made of a moderately ductile material (e.g., 304 stainless steel). The inner sleeve may be made of an epoxy filler. The capping sleeve is placed on a fuel rod which is then severed by using a bolt cutter device. Upon cutting, the capping sleeve deforms in such a manner as to prevent the gross release of radioactive fuel material

  19. Topological Optimization of Rod Mixers

    NASA Astrophysics Data System (ADS)

    Finn, Matthew D.; Thiffeault, Jean-Luc

    2006-11-01

    Stirring of fluid with moving rods is necessary in many practical applications to achieve homogeneity. These rods are topological obstacles that force stretching of fluid elements. The resulting stretching and folding is commonly observed as filaments and striations, and is a precursor to mixing. In a space-time diagram, the trajectories of the rods form a braid [1], and the properties of this braid impose a minimal complexity in the flow. We discuss how optimal mixing protocols can be obtained by a judicious choice of braid, and how these protocols can be implemented using simple gearing [2].[12pt] [1] P. L. Boyland, H. Aref, and M. A. Stremler, JFM 403, 277 (2000).[8pt] [2] J.-L. Thiffeault and M. D. Finn, http://arxiv.org/nlin/0603003

  20. Regulation of free cytosolic Ca2+ concentration in the outer segments of bovine retinal rods by Na-Ca-K exchange measured with fluo-3. I. Efficiency of transport and interactions between cations.

    PubMed

    Schnetkamp, P P; Li, X B; Basu, D K; Szerencsei, R T

    1991-12-05

    Regulation of free cytosolic Ca2+ concentration in the rod outer segments (ROS) isolated from bovine retinas was examined with the fluorescent Ca(2+)-indicating dye fluo-3. In situ calibration of cytosolic fluo-3 was done in the presence of the Ca2+ ionophore A23187 and yielded a dissociation constant of 500 nM for the Ca(2+)-fluo-3 complex. Ca2+ influx in Ca(2+)-depleted ROS was completely abolished when internal Na+ was removed suggesting that Ca2+ influx exclusively occurred via Na-Ca-K exchange. The most striking observation was that Na-Ca-K exchange could mediate a rapid increase in cytosolic free Ca2+ over the most of the usable indicating range of fluo-3 (from 10 nM to 2 microM), even when exposed to free external Ca2+ concentrations as low as 10 nM. From a comparison between changes in free Ca2+ and changes in total Ca2+, we conclude that physiologically occurring changes in cytosolic free Ca2+ are mediated by exchange fluxes less than 1% of the maximal Na-Ca-K exchange flux. The Na-Ca-K exchanger could mediate both K(+)-dependent and K(+)-independent Ca2+ influx; Li+ caused a complete inhibition of K(+)-independent Ca2+ influx, but had no effect on K(+)-dependent Ca2+ influx. We examined the complex interactions of alkali cations with Ca2+ influx and discuss the results in terms of a three-site model for the Na-Ca-K exchanger (Schnetkamp, P. P. M. and Szerencsei, R. T. (1991) J. Biol. Chem. 266, 189-197). Ca2+ competed with one Mg2+ ion or two Na+ ions for binding to a common site. High K+ concentration greatly diminished the ability of Na+ and Mg2+ to compete with Ca2+ for this common site on the exchanger protein. As a result, high internal K+ induced a conformation of the exchange protein that kinetically favoured Ca2+ extrusion.

  1. Investigation of Lightning Rod Shielding Angle

    NASA Astrophysics Data System (ADS)

    Nayel, Mohamed

    This paper studies those parameters affecting the shielding angle of the lightning rod (Franklin Rod) above very tall buildings. It was recommended that the shielding angle of the lightning rod is about 45°∼60°. The downward lightning leader is modeled by using discrete line charges to consider the exponential distribution of charges through the downward leader. The voltage condition used by Rizk is used to investigate the inception of the upward lightning leader. Different air conditions (relative air density and air humidity) are considered for more practical simulation. The influences of lightning parameters and lightning rod height on the shielding angle are studied. The results shows that, lightning leader parameters, lightning rod height and ground slope have series effects on the lightning rod shielding angle. Based on the results, a lightning rod shielding angle for shielding design is recommended to decrease the lightning stroke to the lightning rod.

  2. Control rods in LMFBRs: a physics assessment

    SciTech Connect

    McFarlane, H.F.; Collins, P.J.

    1982-08-01

    This physics assessment is based on roughly 300 control rod worth measurements in ZPPR from 1972 to 1981. All ZPPR assemblies simulated mixed-oxide LMFBRs, representing sizes of 350, 700, and 900 MWe. Control rod worth measurements included single rods, various combinations of rods, and Ta and Eu rods. Additional measurements studied variations in B/sub 4/C enrichment, rod interaction effects, variations in rod geometry, neutron streaming in sodium-filled channels, and axial worth profiles. Analyses were done with design-equivalent methods, using ENDF/B Version IV data. Some computations for the sensitivities to approximations in the methods have been included. Comparisons of these analyses with the experiments have allowed the status of control rod physics in the US to be clearly defined.

  3. Solid-state-laser-rod holder

    DOEpatents

    Gettemy, D.J.; Barnes, N.P.; Griggs, J.E.

    1981-08-11

    The disclosure relates to a solid state laser rod holder comprising Invar, copper tubing, and epoxy joints. Materials and coefficients of expansion of the components of the holder combine with the rod to produce a joint which will give before the rod itself will. The rod may be lased at about 70 to 80/sup 0/K and returned from such a temperature to room temperature repeatedly without its or the holder's destruction.

  4. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors

    PubMed Central

    Mendez, Ana; Burns, Marie E.; Sokal, Izabela; Dizhoor, Alexander M.; Baehr, Wolfgang; Palczewski, Krzysztof; Baylor, Denis A.; Chen, Jeannie

    2001-01-01

    The retina's photoreceptor cells adjust their sensitivity to allow photons to be transduced over a wide range of light intensities. One mechanism thought to participate in sensitivity adjustments is Ca2+ regulation of guanylate cyclase (GC) by guanylate cyclase-activating proteins (GCAPs). We evaluated the contribution of GCAPs to sensitivity regulation in rods by disrupting their expression in transgenic mice. The GC activity from GCAPs−/− retinas showed no Ca2+ dependence, indicating that Ca2+ regulation of GCs had indeed been abolished. Flash responses from dark-adapted GCAPs−/− rods were larger and slower than responses from wild-type rods. In addition, the incremental flash sensitivity of GCAPs−/− rods failed to be maintained at wild-type levels in bright steady light. GCAP2 expressed in GCAPs−/− rods restored maximal light-induced GC activity but did not restore normal flash response kinetics. We conclude that GCAPs strongly regulate GC activity in mouse rods, decreasing the flash sensitivity in darkness and increasing the incremental flash sensitivity in bright steady light, thereby extending the rod's operating range. PMID:11493703

  5. Inverted Control Rod Lock-In Device

    DOEpatents

    Brussalis, W. G.; Bost, G. E.

    1962-12-01

    A mechanism which prevents control rods from dropping out of the reactor core in the event the vessel in which the reactor is mounted should capsize is described. The mechanism includes a pivoted toothed armature which engages the threaded control rod lead screw and prevents removal of the rod whenever the armature is not attracted by the provided electromagnetic means. (AEC)

  6. Hydraulic Actuator for Ganged Control Rods

    NASA Technical Reports Server (NTRS)

    Thompson, D. C.; Robey, R. M.

    1986-01-01

    Hydraulic actuator moves several nuclear-reactor control rods in unison. Electromagnetic pump pushes liquid lithium against ends of control rods, forcing them out of or into nuclear reactor. Color arrows show lithium flow for reactor startup and operation. Flow reversed for shutdown. Conceived for use aboard spacecraft, actuator principle applied to terrestrial hydraulic machinery involving motion of ganged rods.

  7. 21 CFR 876.4270 - Colostomy rod.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Colostomy rod. 876.4270 Section 876.4270 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4270 Colostomy rod. (a) Identification. A colostomy rod is...

  8. 21 CFR 876.4270 - Colostomy rod.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Colostomy rod. 876.4270 Section 876.4270 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4270 Colostomy rod. (a) Identification. A colostomy rod is...

  9. Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods.

    PubMed

    Kast, Brigitte; Schori, Christian; Grimm, Christian

    2016-05-01

    Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retinal morphology and function. Although hypoxia inducible transcription factors 1 and 2 (HIF1, HIF2) are the main regulators of the hypoxic response, photoreceptor protection does not depend on HIF1 in rods. Here we used rod-specific Hif2a single and Hif1a;Hif2a double knockout mice to investigate the potential involvement of HIF2 in rods for protection after hypoxic preconditioning. To identify potential HIF2 target genes in rods we determined the retinal transcriptome of hypoxic control and rod-specific Hif2a knockouts by RNA sequencing. We show that rods do not need HIF2 for hypoxia-induced increased survival after light exposure. The transcriptomic analysis revealed a number of genes that are potentially regulated by HIF2 in rods; among those were Htra1, Timp3 and Hmox1, candidates that are interesting due to their connection to human degenerative diseases of the retina. We conclude that neither HIF1 nor HIF2 are required in photoreceptors for protection by hypoxic preconditioning. We hypothesize that HIF transcription factors may be needed in other cells to produce protective factors acting in a paracrine fashion on photoreceptor cells. Alternatively, hypoxic preconditioning induces a rod-intrinsic response that is independent of HIF transcription factors.

  10. Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors

    PubMed Central

    Hughes, Andrew E. O.; Enright, Jennifer M.; Myers, Connie A.; Shen, Susan Q.; Corbo, Joseph C.

    2017-01-01

    Rod photoreceptors are specialized neurons that mediate vision in dim light and are the predominant photoreceptor type in nocturnal mammals. The rods of nocturnal mammals are unique among vertebrate cell types in having an ‘inverted’ nuclear architecture, with a dense mass of heterochromatin in the center of the nucleus rather than dispersed clumps at the periphery. To test if this unique nuclear architecture is correlated with a unique epigenomic landscape, we performed ATAC-seq on mouse rods and their most closely related cell type, cone photoreceptors. We find that thousands of loci are selectively closed in rods relative to cones as well as >60 additional cell types. Furthermore, we find that the open chromatin profile of photoreceptors lacking the rod master regulator Nrl is nearly indistinguishable from that of native cones, indicating that Nrl is required for selective chromatin closure in rods. Finally, we identified distinct enrichments of transcription factor binding sites in rods and cones, revealing key differences in the cis-regulatory grammar of these cell types. Taken together, these data provide insight into the development and maintenance of photoreceptor identity, and highlight rods as an attractive system for studying the relationship between nuclear organization and local changes in gene regulation. PMID:28256534

  11. Gene expression changes during retinal development and rod specification

    PubMed Central

    Carrigan, Matthew; Hokamp, Karsten; Farrar, G. Jane

    2015-01-01

    Purpose Retinitis pigmentosa (RP) typically results from individual mutations in any one of >70 genes that cause rod photoreceptor cells to degenerate prematurely, eventually resulting in blindness. Gene therapies targeting individual RP genes have shown efficacy at clinical trial; however, these therapies require the surviving photoreceptor cells to be viable and functional, and may be economically feasible for only the more commonly mutated genes. An alternative potential treatment strategy, particularly for late stage disease, may involve stem cell transplants into the photoreceptor layer of the retina. Rod progenitors from postnatal mouse retinas can be transplanted and can form photoreceptors in recipient adult retinas; optimal numbers of transplantable cells are obtained from postnatal day 3–5 (P3–5) retinas. These cells can also be expanded in culture; however, this results in the loss of photoreceptor potential. Gene expression differences between postnatal retinas, cultured retinal progenitor cells (RPCs), and rod photoreceptor precursors were investigated to identify gene expression patterns involved in the specification of rod photoreceptors. Methods Microarrays were used to investigate differences in gene expression between cultured RPCs that have lost photoreceptor potential, P1 retinas, and fresh P5 retinas that contain significant numbers of transplantable photoreceptors. Additionally, fluorescence-activated cell sorting (FACS) sorted Rho-eGFP-expressing rod photoreceptor precursors were compared with Rho-eGFP-negative cells from the same P5 retinas. Differential expression was confirmed with quantitative polymerase chain reaction (q-PCR). Results Analysis of the microarray data sets, including the use of t-distributed stochastic neighbor embedding (t-SNE) to identify expression pattern neighbors of key photoreceptor specific genes, resulted in the identification of 636 genes differentially regulated during rod specification. Forty-four of these

  12. ELECTROMAGNETIC APPARATUS FOR MOVING A ROD

    DOEpatents

    Young, J.N.

    1958-04-22

    An electromagnetic apparatus for moving a rod-like member in small steps in either direction is described. The invention has particular application in the reactor field where the reactor control rods must be moved only a small distance and where the use of mechanical couplings is impractical due to the high- pressure seals required. A neutron-absorbing rod is mounted in a housing with gripping uaits that engage the rod, and coils for magnetizing the gripping units to make them grip, shift, and release the rod are located outside the housing.

  13. Exploiting rod technology. Final report

    SciTech Connect

    1990-06-01

    ROD development was proceeding apace until recent budgetary decisions caused funding support for ROD development to be drastically reduced. The funding which was originally provided by DARPA and the Balanced Technology Initiative (BTI) Office has been cut back to zero from $800K. To determine the aeroballistic coefficients of a candidate dart, ARDEC is currently supporting development out of its own 6.2 funds at about $100K. ARDEC has made slow progress toward achieving this end because of failures in the original dart during testing. It appears that the next dart design to be tested will diverge from the original concept visualized by DARPA and Science and Technology Associates (STA). STA, the design engineer, takes exception to these changes on the basis of inappropriate test conditions and insufficient testing. At this time, the full resolution of this issue will be difficult because of the current management structure, which separates the developer (ARDEC) from the designer (STA).

  14. Fuel rod assembly to manifold attachment

    DOEpatents

    Donck, Harry A.; Veca, Anthony R.; Snyder, Jr., Harold J.

    1980-01-01

    A fuel element is formed with a plurality of fuel rod assemblies detachably connected to an overhead support with each of the fuel rod assemblies having a gas tight seal with the support to allow internal fission gaseous products to flow without leakage from the fuel rod assemblies into a vent manifold passageway system on the support. The upper ends of the fuel rod assemblies are located at vertically extending openings in the support and upper threaded members are threaded to the fuel rod assemblies to connect the latter to the support. The preferred threaded members are cap nuts having a dome wall encircling an upper threaded end on the fuel rod assembly and having an upper sealing surface for sealing contact with the support. Another and lower seal is achieved by abutting a sealing surface on each fuel rod assembly with the support. A deformable portion on the cap nut locks the latter against inadvertent turning off the fuel rod assembly. Orienting means on the fuel rod and support primarily locates the fuel rods azimuthally for reception of a deforming tool for the cap nut. A cross port in the fuel rod end plug discharges into a sealed annulus within the support, which serves as a circumferential chamber, connecting the manifold gas passageways in the support.

  15. Adaptive potentiation in rod photoreceptors after light exposure.

    PubMed

    McKeown, Alex S; Kraft, Timothy W

    2014-06-01

    Photoreceptors adapt to changes in illumination by altering transduction kinetics and sensitivity, thereby extending their working range. We describe a previously unknown form of rod photoreceptor adaptation in wild-type (WT) mice that manifests as a potentiation of the light response after periods of conditioning light exposure. We characterize the stimulus conditions that evoke this graded hypersensitivity and examine the molecular mechanisms of adaptation underlying the phenomenon. After exposure to periods of saturating illumination, rods show a 10-35% increase in circulating dark current, an adaptive potentiation (AP) to light exposure. This potentiation grows as exposure to light is extended up to 3 min and decreases with longer exposures. Cells return to their initial dark-adapted sensitivity with a time constant of recovery of ∼7 s. Halving the extracellular Mg concentration prolongs the adaptation, increasing the time constant of recovery to 13.3 s, but does not affect the magnitude of potentiation. In rods lacking guanylate cyclase activating proteins 1 and 2 (GCAP(-/-)), AP is more than doubled compared with WT rods, and halving the extracellular Mg concentration does not affect the recovery time constant. Rods from a mouse expressing cyclic nucleotide-gated channels incapable of binding calmodulin also showed a marked increase in the amplitude of AP. Application of an insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitor (Tyrphostin AG1024) blocked AP, whereas application of an insulin receptor kinase inhibitor (HNMPA(AM)3) failed to do so. A broad-acting tyrosine phosphatase inhibitor (orthovanadate) also blocked AP. Our findings identify a unique form of adaptation in photoreceptors, so that they show transient hypersensitivity to light, and are consistent with a model in which light history, acting via the IGF-1R, can increase the sensitivity of rod photoreceptors, whereas the photocurrent overshoot is regulated by Ca-calmodulin and Ca(2

  16. Rod lengthening with the magnetically controlled growing rod: factors influencing rod slippage and reduced gains during distractions.

    PubMed

    Cheung, Jason Pui Yin; Yiu, Karen Kar Lum; Samartzis, Dino; Kwan, Kenny; Tan, Boon-Beng; Cheung, Kenneth Man Chee

    2017-08-01

    Prospective study OBJECTIVE.: To identify the factors that are associated with rod slippage and to study the pattern of achieved length gain with a standard distraction methodology. Ability to achieve successful magnetically controlled growing rod (MCGR) distraction is crucial for gradual spine lengthening. Rod slippage has been described as a failure of internal magnet rotation leading to a slippage and an inability to distract the rod. However, its onset, significance and risk factors are currently unknown. In addition, how this phenomenon pertains to actual distracted lengths is unknown. A total of 22 patients with MCGR and at least 6 distraction episodes were prospectively studied. Patients with rod slippage occurring ≤6 distraction episodes were considered early rod slippage while those >6 or have yet not slipped were grouped as late rod slippage. The association of parameters including body habitus, maturity status, age of implantation, total number of distractions, months of distraction from initial implantation, initial and postoperative Cobb angle, T1-T12, T1-S1, T5-T12 kyphosis, curve flexibility, fusion block length, and distance between magnets in dual rods and between the magnets and apex of the curve with early or late onset of rod slippage was studied. Differences between expected and achieved distraction lengths were assessed with reference to rod slippage episodes and rod exchanges to determine any patterns of diminishing returns. Patients had mean age of 7.1 years at diagnosis with mean follow-up of 49.8 months. A mean 32.4 distractions were performed per patient. Early rod slippage occurred in 14 patients and late rod slippage occurred in 8 patients. Increased height, weight, body mass index, older age, increased T1-12 and T1-S1 lengths, and less distance between magnets were significantly associated with early rod slippage. Expected distraction lengths did not translate to achieved distraction lengths and reduced gains were only observed after

  17. Rapid kinetics of endocytosis at rod photoreceptor synapses depends upon endocytic load and calcium.

    PubMed

    Cork, Karlene M; Thoreson, Wallace B

    2014-05-01

    Release from rods is triggered by the opening of L-type Ca2+ channels that lie beneath synaptic ribbons. After exocytosis, vesicles are retrieved by compensatory endocytosis. Previous work showed that endocytosis is dynamin-dependent in rods but dynamin-independent in cones. We hypothesized that fast endocytosis in rods may also differ from cones in its dependence upon the amount of Ca2+ influx and/or endocytic load. We measured exocytosis and endocytosis from membrane capacitance (C m) changes evoked by depolarizing steps in voltage clamped rods from tiger salamander retinal slices. Similar to cones, the time constant for endocytosis in rods was quite fast, averaging <200 ms. We manipulated Ca2+ influx and the amount of vesicle release by altering the duration and voltage of depolarizing steps. Unlike cones, endocytosis kinetics in rods slowed after increasing Ca2+ channel activation with longer step durations or more strongly depolarized voltage steps. Endocytosis kinetics also slowed as Ca2+ buffering was decreased by replacing BAPTA (10 or 1 mM) with the slower Ca2+ buffer EGTA (5 or 0.5 mM) in the pipette solution. These data provide further evidence that endocytosis mechanisms differ in rods and cones and suggest that endocytosis in rods is regulated by both endocytic load and local Ca2+ levels.

  18. Rapid kinetics of endocytosis at rod photoreceptor synapses depends upon endocytic load and calcium

    PubMed Central

    CORK, KARLENE M.; THORESON, WALLACE B.

    2015-01-01

    Release from rods is triggered by the opening of L-type Ca2+ channels that lie beneath synaptic ribbons. After exocytosis, vesicles are retrieved by compensatory endocytosis. Previous work showed that endocytosis is dynamin-dependent in rods but dynamin-independent in cones. We hypothesized that fast endocytosis in rods may also differ from cones in its dependence upon the amount of Ca2+ influx and/or endocytic load. We measured exocytosis and endocytosis from membrane capacitance (Cm) changes evoked by depolarizing steps in voltage clamped rods from tiger salamander retinal slices. Similar to cones, the time constant for endocytosis in rods was quite fast, averaging <200 ms. We manipulated Ca2+ influx and the amount of vesicle release by altering the duration and voltage of depolarizing steps. Unlike cones, endocytosis kinetics in rods slowed after increasing Ca2+ channel activation with longer step durations or more strongly depolarized voltage steps. Endocytosis kinetics also slowed as Ca2+ buffering was decreased by replacing BAPTA (10 or 1 mM) with the slower Ca2+ buffer EGTA (5 or 0.5 mM) in the pipette solution. These data provide further evidence that endocytosis mechanisms differ in rods and cones and suggest that endocytosis in rods is regulated by both endocytic load and local Ca2+ levels. PMID:24735554

  19. YscP and YscU switch the substrate specificity of the Yersinia type III secretion system by regulating export of the inner rod protein YscI.

    PubMed

    Wood, Sarah E; Jin, Jin; Lloyd, Scott A

    2008-06-01

    Pathogenic yersiniae utilize a type III secretion system to inject antihost factors, called Yops, directly into the cytosol of eukaryotic cells. The Yops are injected via a needle-like structure, comprising the YscF protein, on the bacterial surface. While the needle is being assembled, Yops cannot be secreted. YscP and YscU switch the substrate specificity of the secretion system to enable Yop export once the needle attains its proper length. Here, we demonstrate that the inner rod protein YscI plays a critical role in substrate specificity switching. We show that YscI is secreted by the type III secretion system and that YscI secretion by a yscP mutant is abnormally elevated. Furthermore, we show that mutations in the cytoplasmic domain of YscU reduce YscI secretion by the yscP null strain. We also demonstrate that mutants expressing one of three forms of YscI (those with mutations Q84A, L87A, and L96A) secrete substantial amounts of Yops yet exhibit severe defects in needle formation. In the absence of YscP, mutants with the same changes in YscI assemble needles but are unable to secrete Yops. Together, these results suggest that the formation of the inner rod, not the needle, is critical for substrate specificity switching and that YscP and YscU exert their effects on substrate export by controlling the secretion of YscI.

  20. High temperature control rod assembly

    DOEpatents

    Vollman, Russell E.

    1991-01-01

    A high temperature nuclear control rod assembly comprises a plurality of substantially cylindrical segments flexibly joined together in succession by ball joints. The segments are made of a high temperature graphite or carbon-carbon composite. The segment includes a hollow cylindrical sleeve which has an opening for receiving neutron-absorbing material in the form of pellets or compacted rings. The sleeve has a threaded sleeve bore and outer threaded surface. A cylindrical support post has a threaded shaft at one end which is threadably engaged with the sleeve bore to rigidly couple the support post to the sleeve. The other end of the post is formed with a ball portion. A hollow cylindrical collar has an inner threaded surface engageable with the outer threaded surface of the sleeve to rigidly couple the collar to the sleeve. the collar also has a socket portion which cooperates with the ball portion to flexibly connect segments together to form a ball and socket-type joint. In another embodiment, the segment comprises a support member which has a threaded shaft portion and a ball surface portion. The threaded shaft portion is engageable with an inner threaded surface of a ring for rigidly coupling the support member to the ring. The ring in turn has an outer surface at one end which is threadably engageably with a hollow cylindrical sleeve. The other end of the sleeve is formed with a socket portion for engagement with a ball portion of the support member. In yet another embodiment, a secondary rod is slidably inserted in a hollow channel through the center of the segment to provide additional strength. A method for controlling a nuclear reactor utilizing the control rod assembly is also included.

  1. Chemotaxis of Nonbiological Colloidal Rods

    NASA Astrophysics Data System (ADS)

    Hong, Yiying; Blackman, Nicole M. K.; Kopp, Nathaniel D.; Sen, Ayusman; Velegol, Darrell

    2007-10-01

    Chemotaxis is the movement of organisms toward or away from a chemical attractant or toxin by a biased random walk process. Here we describe the first experimental example of chemotaxis outside biological systems. Platinum-gold rods 2.0μm long exhibit directed movement toward higher hydrogen peroxide concentrations through “active diffusion.” Brownian dynamics simulations reveal that no “temporal sensing” algorithm, commonly attributed to bacteria, is necessary; rather, the observed chemotaxis can be explained by random walk physics in a gradient of the active diffusion coefficient.

  2. Reactor control rod timing system. [LMFBR

    DOEpatents

    Wu, P.T.K.

    1980-03-18

    A fluid driven jet-edge whistle timing system is described for control rods of a nuclear reactor for producing real-time detection of the timing of each control rod in its scram operation. An important parameter in reactor safety, particularly for liquid metal fast breeder reactors (LMFBR), is the time deviation between the time the control rod is released and the time the rod actually reaches the down position. The whistle has a nearly pure tone signal with center frequency (above 100 kHz) far above the frequency band in which the energy of the background noise is concentrated. Each control rod can be fitted with a whistle with a different frequency so that there is no ambiguity in differentiating the signal from each control rod.

  3. How To Make Singing Rods Scream

    NASA Astrophysics Data System (ADS)

    Minnix, Richard B.; Carpenter, D. Rae; McNairy, William W.

    1999-11-01

    The singing rod has long been a favorite of physics demonstrators. Longitudinal vibrations are easily excited for mode numbers n = 1 and n = 2 for short rods and even higher mode numbers for rods about a meter or greater in length. Aluminum is favored because of its higher Q, or tendency to maintain its resonance with a minimum of damping. Occasionally one finds by chance that an aluminum rod screams intermittently when one of the transverse modes becomes coupled to the longitudinal mode as a result of an integer ratio between the longitudinal and transverse frequencies. Computer software is now available to Fourier analyze the various waves emanating from a rod and read out the numerical values of the frequencies. This has made it possible to measure the multiplicity of frequencies present when coupling occurs and compare theoretical and experimental values. Demonstrations, with accompanying data on frequencies and mode numbers, will be shown for rods of both circular and square cross section.

  4. Fuel rod retention device for a nuclear reactor

    DOEpatents

    Hylton, Charles L.

    1984-01-01

    A device is described for supporting a nuclear fuel rod in a fuel rod assembly which allows the rod to be removed without disturbing other rods in the assembly. A fuel rod cap connects the rod to a bolt which is supported in the assembly end fitting by means of a locking assembly. The device is designed so that the bolt is held securely during normal reactor operation yet may be easily disengaged and the fuel rod removed when desired.

  5. Growth and Morphology of Rod Eutectics

    SciTech Connect

    Jing Teng; Shan Liu; R. Trivedi

    2008-03-17

    The formation of rod eutectic microstructure is investigated systematically in a succinonitrile-camphor alloy of eutectic composition by using the directional solidification technique. A new rod eutectic configuration is observed in which the rods form with elliptical cylindrical shape. Two different orientations of the ellipse are observed that differ by a 90{sup o} rotation such that the major and the minor axes are interchanged. Critical experiments in thin samples, where a single layer of rods forms, show that the spacing and orientation of the elliptic rods are governed by the growth rate and the sample thickness. In thicker samples, multi layers of rods form with circular cross-section and the scaling law between the spacing and velocity predicted by the Jackson and Hunt model is validated. A theoretical model is developed for a two-dimensional array of elliptical rods that are arranged in a hexagonal or a square array, and the results are shown to be consistent with the experimental observations. The model of elliptic rods is also shown to reduce to that for the circular rod eutectic when the lengths of the two axes are equal, and to the lamellar eutectic model when one of the axes is much larger than the other one.

  6. Rod-climbing effect in Newtonian fluids.

    PubMed

    Bonn, Daniel; Kobylko, Mathias; Bohn, Steffen; Meunier, Jacques; Morozov, Alexander; van Saarloos, Wim

    2004-11-19

    When a rotating rod is brought into a polymer melt or concentrated polymer solution, the meniscus climbs the rod. This spectacular rod climbing is due to the normal stresses present in the polymer fluid and is thus a purely non-Newtonian effect. A similar rod climbing of an interface between two fluids has therefore been taken as a signature that one of the fluids exhibits normal stress effects. We show here, however, that the effect can occur with simple Newtonian fluids: it occurs when a Taylor-Couette instability happens in the less viscous of the two liquids but not in the more viscous one.

  7. Acoustic loading effects on oscillating rod bundles

    SciTech Connect

    Lin, W.H.

    1980-01-01

    An analytical study of the interaction between an infinite acoustic medium and a cluster of circular rods is described. The acoustic field due to oscillating rods and the acoustic loading on the rods are first solved in a closed form. The acoustic loading is then used as a forcing function for rod responses, and the acousto-elastic couplings are solved simultaneously. Numerical examples are presented for several cases to illustrate the effects of various system parameters on the acoustic reaction force coefficients. The effect of the acoustic loading on the coupled eigenfrequencies are discussed.

  8. Equations determine reasonable rod pump submergence depth

    SciTech Connect

    Hu Yongquan; Cai Wizhong

    1997-03-24

    A reasonable rod pump submergence depth can be calculated by combining fluid level changes with piston travel. Submergence depth is affected by the pump fill factor, reservoir fluid viscosity, rod pump type, and pumping parameters such as pump diameter, polished-rod stroke length, and pumping speed. Fluid level velocity can be obtained with an energy balance, and piston travel rate is based on the polished-rod travel. The paper describes the pump fill factor, piston travel velocity, fluid level rise, flow coefficient, reasonable submergence depth, and results from equations.

  9. Temperature actuated automatic safety rod release

    DOEpatents

    Hutter, Ernest; Pardini, John A.; Walker, David E.

    1987-01-01

    A temperature-actuated apparatus is disclosed for releasably supporting a safety rod in a nuclear reactor, comprising a safety rod upper adapter having a retention means, a drive shaft which houses the upper adapter, and a bimetallic means supported within the drive shaft and having at least one ledge which engages a retention means of the safety rod upper adapter. A pre-determined increase in temperature causes the bimetallic means to deform so that the ledge disengages from the retention means, whereby the bimetallic means releases the safety rod into the core of the reactor.

  10. Temperature actuated automatic safety rod release

    DOEpatents

    Hutter, E.; Pardini, J.A.; Walker, D.E.

    1984-03-13

    A temperature-actuated apparatus is disclosed for releasably supporting a safety rod in a nuclear reactor, comprising a safety rod upper adapter having a retention means, a drive shaft which houses the upper adapter, and a bimetallic means supported within the drive shaft and having at least one ledge which engages a retention means of the safety rod upper adapter. A pre-determined increase in temperature causes the bimetallic means to deform so that the ledge disengages from the retention means, whereby the bimetallic means releases the safety rod into the core of the reactor.

  11. Effects of rod worth and drop speed on the BWR off-center rod drop accident

    SciTech Connect

    Cokinos, D.M.; Carew, J.F.

    1985-01-01

    BWR off-center RDA calculations have been performed for selected rod worths and drop speeds. While in all cases the peak fuel enthalpy was well below the 280 cal/g fuel criterion, a substantial sensitivity to control rod worth and rod drop speed was observed.

  12. Connexin 36 and Rod Bipolar Cell Independent Rod Pathways Drive Retinal Ganglion Cells and Optokinetic Reflexes

    PubMed Central

    Cowan, Cameron S.; Abd-El-Barr, Muhammad; van der Heijden, Meike; Lo, Eric M.; Paul, David; Bramblett, Debra E.; Lem, Janis; Simons, David L.; Wu, Samuel M.

    2016-01-01

    Rod pathways are a parallel set of synaptic connections which enable night vision by relaying and processing rod photoreceptor light responses. We use dim light stimuli to isolate rod pathway contributions to downstream light responses then characterize these contributions in knockout mice lacking rod transducin-α (Trα), or certain pathway components associated with subsets of rod pathways. These comparisons reveal that rod pathway driven light sensitivity in retinal ganglion cells (RGCs) is entirely dependent on Trα, but partially independent of connexin 36 (Cx36) and rod bipolar cells. Pharmacological experiments show that rod pathway-driven and Cx36-independent RGC ON responses are also metabotropic glutamate receptor 6-dependent. To validate the RGC findings in awake, behaving animals we measured optokinetic reflexes (OKRs), which are sensitive to changes in ON pathways. Scotopic OKR contrast sensitivity was lost in Trα−/− mice, but indistinguishable from controls in Cx36−/− and rod bipolar cell knockout mice. Mesopic OKRs were also altered in mutant mice: Trα−/− mice had decreased spatial acuity, rod BC knockouts had decreased sensitivity, and Cx36−/− mice had increased sensitivity. These results provide compelling evidence against the complete Cx36 or rod BC dependence of night vision's ON component. Further, the findings suggest the parallel nature of rod pathways provides considerable redundancy to scotopic light sensitivity but distinct contributions to mesopic responses through complicated interactions with cone pathways. PMID:26718442

  13. Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina

    PubMed Central

    Jin, Nan Ge; Chuang, Alice Z; Masson, Philippe J; Ribelayga, Christophe P

    2015-01-01

    Key points Rod photoreceptors play a key role in vision in dim light; in the mammalian retina, although rods are anatomically connected or coupled by gap junctions, a type of electrical synapse, the functional importance and regulation of rod coupling has remained elusive. We have developed a new technique in the mouse: perforated patch-clamp recording of rod inner segments in isolated intact retinae maintained by superfusion. We find that rod electrical coupling is controlled by a circadian clock and dopamine, and is weak during the day and stronger at night. The results also indicate that the signal-to-noise ratio for a dim light response is increased at night because of coupling. Our observations will provide a framework for understanding the daily variations in human vision as well as the basis of specific retinal malfunctions. Abstract Rod single-photon responses are critical for vision in dim light. Electrical coupling via gap junction channels shapes the light response properties of vertebrate photoreceptors, but the regulation of rod coupling and its impact on the single-photon response have remained unclear. To directly address these questions, we developed a perforated patch-clamp recording technique and recorded from single rod inner segments in isolated intact neural mouse retinae, maintained by superfusion. Experiments were conducted at different times of the day or under constant environmental conditions, at different times across the circadian cycle. We show that rod electrical coupling is regulated by a circadian clock and dopamine, so that coupling is weak during the day and strong at night. Altogether, patch-clamp recordings of single-photon responses in mouse rods, tracer coupling, receptive field measurements and pharmacological manipulations of gap junction and dopamine receptor activity provide compelling evidence that rod coupling is modulated in a circadian manner. These data are consistent with computer modelling. At night, single

  14. Longitudinal Impact of Rods: A Continuing Experiment.

    ERIC Educational Resources Information Center

    Britton, W. G. B.; And Others

    1978-01-01

    Describes an undergraduate experiment of research potential. The experiment cconsists of measuring the time of contact of a metal rod bouncing on a steel base as a function of the velocity of impact, length, diameter, and material of the rod. (GA)

  15. Tipping Time of a Quantum Rod

    ERIC Educational Resources Information Center

    Parrikar, Onkar

    2010-01-01

    The behaviour of a quantum rod, pivoted at its lower end on an impenetrable floor and restricted to moving in the vertical plane under the gravitational potential, is studied analytically under the approximation that the rod is initially localized to a "small-enough" neighbourhood around the point of classical unstable equilibrium. It is shown…

  16. Tipping Time of a Quantum Rod

    ERIC Educational Resources Information Center

    Parrikar, Onkar

    2010-01-01

    The behaviour of a quantum rod, pivoted at its lower end on an impenetrable floor and restricted to moving in the vertical plane under the gravitational potential, is studied analytically under the approximation that the rod is initially localized to a "small-enough" neighbourhood around the point of classical unstable equilibrium. It is shown…

  17. Rod-Coil Block Polyimide Copolymers

    NASA Technical Reports Server (NTRS)

    Meador, Mary Ann B. (Inventor); Kinder, James D. (Inventor)

    2005-01-01

    This invention is a series of rod-coil block polyimide copolymers that are easy to fabricate into mechanically resilient films with acceptable ionic or protonic conductivity at a variety of temperatures. The copolymers consist of short-rigid polyimide rod segments alternating with polyether coil segments. The rods and coil segments can be linear, branched or mixtures of linear and branched segments. The highly incompatible rods and coil segments phase separate, providing nanoscale channels for ion conduction. The polyimide segments provide dimensional and mechanical stability and can be functionalized in a number of ways to provide specialized functions for a given application. These rod-coil black polyimide copolymers are particularly useful in the preparation of ion conductive membranes for use in the manufacture of fuel cells and lithium based polymer batteries.

  18. Crystal truncation rods from miscut surfaces

    DOE PAGES

    Petach, Trevor A.; Mehta, Apurva; Toney, Michael F.; ...

    2017-05-08

    Crystal truncation rods are used to study surface and interface structure. Since real surfaces are always somewhat miscut from a low index plane, it is important to study the effect of miscuts on crystal truncation rods. We develop a model that describes the truncation rod scattering from miscut surfaces that have steps and terraces. We show that nonuniform terrace widths and jagged step edges are both forms of roughness that decrease the intensity of the rods. Nonuniform terrace widths also result in a broad peak that overlaps the rods. We use our model to characterize the terrace width distribution andmore » step edge jaggedness on three SrTiO3 (001) samples, showing excellent agreement between the model and the data, confirmed by atomic force micrographs of the surface morphology. As a result, we expect our description of terrace roughness will apply to many surfaces, even those without obvious terracing.« less

  19. Vortex Noise from Rotating Cylindrical Rods

    NASA Technical Reports Server (NTRS)

    Stowell, E Z; Deming, A F

    1935-01-01

    A series of round rods of the some diameter were rotated individually about the mid-point of each rod. Vortices are shed from the rods when in motion, giving rise to the emission of sound. With the rotating system placed in the open air, the distribution of sound in space, the acoustical power output, and the spectral distribution have been studied. The frequency of emission of vortices from any point on the rod is given by the formula von Karman. From the spectrum estimates are made of the distribution of acoustical power along the rod, the amount of air concerned in sound production, the "equivalent size" of the vortices, and the acoustical energy content for each vortex.

  20. Rod-Coil Block Polyimide Copolymers

    NASA Technical Reports Server (NTRS)

    Meador, Mary Ann B. (Inventor); Kinder, James D. (Inventor)

    2005-01-01

    This invention is a series of rod-coil block polyimide copolymers that are easy to fabricate into mechanically resilient films with acceptable ionic or protonic conductivity at a variety of temperatures. The copolymers consist of short-rigid polyimide rod segments alternating with polyether coil segments. The rods and coil segments can be linear, branched or mixtures of linear and branched segments. The highly incompatible rods and coil segments phase separate, providing nanoscale channels for ion conduction. The polyimide segments provide dimensional and mechanical stability and can be functionalized in a number of ways to provide specialized functions for a given application. These rod-coil black polyimide copolymers are particularly useful in the preparation of ion conductive membranes for use in the manufacture of fuel cells and lithium based polymer batteries.

  1. Looking South at North End of Rod Loading Line Including ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking South at North End of Rod Loading Line Including Welding Area Within Rod Loading building - Hematite Fuel Fabrication Facility, Rod Loading Building, 3300 State Road P, Festus, Jefferson County, MO

  2. Isolation of rod and cone contributions to cat ganglion cells by a method of light exchange.

    PubMed

    Rodieck, R W; Rushton, W A

    1976-01-01

    1. The great majority of cat retinal ganglion cells are known to receive signals from rods and from a single (green) cone type. The centre region of the receptive fields of these cells was stimulated by a spot that changed back and forth from orange to white. By adjusting the intensity of the white spot relative to that of the orange a condition could be established at which the photon-catch rate of the rods remained unchanged during the orange-white exchange. At this intensity setting, termed the rod isolept, rods are thus unstimulated by the exchange, however intense, and the ganglion-cell response was found to be due entirely to the green cones. At another intensity setting of the white spot relative to the orange (cone isolept), the photon catch of the green cones remained unchanged during the exchange and ganglion-cell responses were found to arise entirely from the rods. 2. A neutral wedge in the combined exchange beam (but not in the steady background that covered the whole receptive field) regulated the size of the exchange stimulus and thus the magnitude of the ganglion-cell discharge heard from a loud speaker to the exchange. Exchange threshold was the wedge setting at which this change in firing rate could only just be heard. 3. At the cone isolept, cones remain unstimulated however intense the exchange stimulus, and the rod increment threshold curve was determined over its full range from absolute threshold up to saturation. Likewise, at the rod isolept, the cone increment threshold curve was determined over the same intensity range as for the rods. Rod saturation was found to occur at the point where the cone increment threshold curve began to rise from its absolute threshold level toward its Weber region. 4. The exchange approach also enabled both rod and cone dark-adaptation curves following a strong bleaching exposure to be obtained in the same experiment by moving successively between the cone and rod isolepts. At the cone isolept the time course

  3. Eulerian Formulation of Spatially Constrained Elastic Rods

    NASA Astrophysics Data System (ADS)

    Huynen, Alexandre

    Slender elastic rods are ubiquitous in nature and technology. For a vast majority of applications, the rod deflection is restricted by an external constraint and a significant part of the elastic body is in contact with a stiff constraining surface. The research work presented in this doctoral dissertation formulates a computational model for the solution of elastic rods constrained inside or around frictionless tube-like surfaces. The segmentation strategy adopted to cope with this complex class of problems consists in sequencing the global problem into, comparatively simpler, elementary problems either in continuous contact with the constraint or contact-free between their extremities. Within the conventional Lagrangian formulation of elastic rods, this approach is however associated with two major drawbacks. First, the boundary conditions specifying the locations of the rod centerline at both extremities of each elementary problem lead to the establishment of isoperimetric constraints, i.e., integral constraints on the unknown length of the rod. Second, the assessment of the unilateral contact condition requires, in principle, the comparison of two curves parametrized by distinct curvilinear coordinates, viz. the rod centerline and the constraint axis. Both conspire to burden the computations associated with the method. To streamline the solution along the elementary problems and rationalize the assessment of the unilateral contact condition, the rod governing equations are reformulated within the Eulerian framework of the constraint. The methodical exploration of both types of elementary problems leads to specific formulations of the rod governing equations that stress the profound connection between the mechanics of the rod and the geometry of the constraint surface. The proposed Eulerian reformulation, which restates the rod local equilibrium in terms of the curvilinear coordinate associated with the constraint axis, describes the rod deformed configuration

  4. Morphoelastic rods Part II: Growing birods

    NASA Astrophysics Data System (ADS)

    Lessinnes, Thomas; Moulton, Derek E.; Goriely, Alain

    2017-03-01

    The general problem of determining the shape and response of two attached growing elastic Kirchhoff rods is considered. A description of the kinematics of the individual interacting rods is introduced. Each rod has a given intrinsic shape and constitutive laws, and a map associating points on the two rods is defined. The resulting filamentary structure, a growing birod, can be seen as a new filamentary structure. This kinematic description is used to derive the general equilibrium equations for the shape of the rods under loads, or equivalently, for the new birod. It is shown that, in general, the birod is not simply a Kirchhoff rod but rather, due to the internal constraints, new effects can appear. The two-dimensional restriction is then considered explicitly and the limit for small deformation is shown to be equivalent to the classic Timsohenko bi-metallic strip problem. A number of examples and applications are presented. In particular, the problem of two attached rods with intrinsic helical shape and uniform growth is computed in detail and a host of new interesting solutions and bifurcations are observed.

  5. Control Rod Malfunction at the NRAD Reactor

    SciTech Connect

    Thomas L. Maddock

    2010-05-01

    The neutron Radiography Reactor (NRAD) is a training, research, and isotope (TRIGA) reactor located at the INL. The reactor is normally shut down by the insertion of three control rods that drop into the core when power is removed from electromagnets. During a routine shutdown, indicator lights on the console showed that one of the control rods was not inserted. It was initially thought that the indicator lights were in error because of a limit switch that was out of adjustment. Through further testing, it was determined that the control rod did not drop when the scram switch was initially pressed. The control rod anomaly led to a six month shutdown of the reactor and an in depth investigation of the reactor protective system. The investigation looked into: scram switch operation, console modifications, and control rod drive mechanisms. A number of latent issues were discovered and corrected during the investigation. The cause of the control rod malfunction was found to be a buildup of corrosion in the control rod drive mechanism. The investigation resulted in modifications to equipment, changes to both operation and maintenance procedures, and additional training. No reoccurrences of the problem have been observed since corrective actions were implemented.

  6. DEVICE FOR CONTROLLING INSERTION OF ROD

    DOEpatents

    Beaty, B.J.

    1958-10-14

    A device for rapidly inserting a safety rod into a nuclear reactor upon a given signal or in the event of a power failure in order to prevent the possibility of extensive damage caused by a power excursion is described. A piston is slidably mounted within a vertical cylinder with provision for an electromagnetic latch at the top of the cylinder. This assembly, with a safety rod attached to the piston, is mounted over an access port to the core region of the reactor. The piston is normally latched at the top of the cylinder with the safety rod clear of the core area, however, when the latch is released, the piston and rod drop by their own weight to insert the rod. Vents along the side of the cylinder permit the escape of the air entrapped under the piston over the greater part of the distance, however, at the end of the fall the entrapped air is compressed thereby bringing the safety rod gently to rest, thus providing for a rapid automatic insertion of the rod with a minimum of structural shock.

  7. Magnetically controlled growing rods for scoliosis surgery.

    PubMed

    Metkar, Umesh; Kurra, Swamy; Quinzi, David; Albanese, Stephen; Lavelle, William F

    2017-02-01

    Early onset scoliosis can be both a disfiguring as well as a life threatening condition. When more conservative treatments fail, pediatric spinal surgeons are forced to consider operative interventions. Traditionally, these interventions have involved the insertion of a variety of implants into the patient with a limited number of anchor points controlling the spine. In the past, these pediatric patients have had multiple surgeries for elective lengthening of these devices to facilitate their growth while attempting to control the scoliosis. These patients often experience a physical and emotional toll from their multiple repeated surgeries. Growing spine techniques have also had a noted high complication rate due to implant dislodgement and infections. Recently, the development of non-invasively, self-lengthening growing rods has occurred. These devices have the potential to allow for the devices to be lengthened magnetically in a conscious patient in the surgeon's office. Areas covered: This review summarized previously published articles in the English literature using a key word search in PubMed for: 'magnetically controlled growing rods', 'Magec rods', 'magnetic growing rods' and 'growing rods'. Expert commentary: Magnetically controlled growing rods have an advantage over growing rods in lengthening the growing spine in the absence of repetitive surgeries.

  8. Granular materials interacting with thin flexible rods

    NASA Astrophysics Data System (ADS)

    Neto, Alfredo Gay; Campello, Eduardo M. B.

    2017-04-01

    In this work, we develop a computational model for the simulation of problems wherein granular materials interact with thin flexible rods. We treat granular materials as a collection of spherical particles following a discrete element method (DEM) approach, while flexible rods are described by a large deformation finite element (FEM) rod formulation. Grain-to-grain, grain-to-rod, and rod-to-rod contacts are fully permitted and resolved. A simple and efficient strategy is proposed for coupling the motion of the two types (discrete and continuum) of materials within an iterative time-stepping solution scheme. Implementation details are shown and discussed. Validity and applicability of the model are assessed by means of a few numerical examples. We believe that robust, efficiently coupled DEM-FEM schemes can be a useful tool to the simulation of problems wherein granular materials interact with thin flexible rods, such as (but not limited to) bombardment of grains on beam structures, flow of granular materials over surfaces covered by threads of hair in many biological processes, flow of grains through filters and strainers in various industrial segregation processes, and many others.

  9. Control rod housing alignment and repair method

    SciTech Connect

    Dixon, R.C.; Deaver, G.A.; Punches, J.R.; Singleton, G.E.; Erbes, J.G.; Offer, H.P.

    1992-04-07

    This patent describes a method for underwater welding of a control rod drive housing inserted through a stub tube to maintain requisite alignment and elevation of the top of the control rod drive housing to an overlying and corresponding aperture in a core plate as measured by an alignment device which determines the relative elevation and angularity with respect to the aperture. It comprises providing a welding cylinder dependent from the alignment device such that the elevation of the top of the welding cylinder is in a fixed relationship to the alignment device and is gas-proof; pressurizing the welding cylinder with inert welding gas sufficient to maintain the interior of the welding cylinder dry; lowering the welding cylinder through the aperture in the core plate by depending the cylinder with respect to the alignment device, the lowering including lowering through and adjusting the elevation relationship of the welding cylinder to the alignment device such that when the alignment device is in position to measure the elevation and angularity of the new control rod drive housing, the lower distal end of the welding cylinder extends below the upper periphery of the stub where welding is to occur; inserting a new control rod drive housing through the stub tube and positioning the control rod drive housing to a predetermined relationship to the anticipated final position of the control rod drive housing; providing welding implements transversely rotatably mounted interior of the welding cylinder relative to the alignment device such that the welding implements may be accurately positioned for dispensing weldment around the periphery of the top of the stub tube and at the side of the control rod drive housing; measuring the elevation and angularity of the control rod drive housing; and dispensing weldment along the top of the stub tube and at the side of the control rod drive housing.

  10. The Mechanical Effect of Rod Contouring on Rod-Screw System Strength in Spine Fixation

    PubMed Central

    Karakasli, Ahmet; Karaarslan, Ahmet A.; Ozcanhan, Mehmet Hilal; Ertem, Fatih; Erduran, Mehmet

    2016-01-01

    Objective Rod-screw fixation systems are widely used for spinal instrumentation. Although many biomechanical studies on rod-screw systems have been carried out, but the effects of rod contouring on the construct strength is still not very well defined in the literature. This work examines the mechanical impact of straight, 20° kyphotic, and 20° lordotic rod contouring on rod-screw fixation systems, by forming a corpectomy model. Methods The corpectomy groups were prepared using ultra-high molecular weight polyethylene samples. Non-destructive loads were applied during flexion/extension and torsion testing. Spine-loading conditions were simulated by load subjections of 100 N with a velocity of 5 mm min-1, to ensure 8.4-Nm moment. For torsional loading, the corpectomy models were subjected to rotational displacement of 0.5° s-1 to an end point of 5.0°, in a torsion testing machine. Results Under both flexion and extension loading conditions the stiffness values for the lordotic rod-screw system were the highest. Under torsional loading conditions, the lordotic rod-screw system exhibited the highest torsional rigidity. Conclusion We concluded that the lordotic rod-screw system was the most rigid among the systems tested and the risk of rod and screw failure is much higher in the kyphotic rod-screw systems. Further biomechanical studies should be attempted to compare between different rod kyphotic angles to minimize the kyphotic rod failure rate and to offer a more stable and rigid rod-screw construct models for surgical application in the kyphotic vertebrae. PMID:27651858

  11. VARIABLE AREA CONTROL ROD FOR NUCLEAR REACTOR

    DOEpatents

    Huston, N.E.

    1960-05-01

    A control rod is described which permits continual variation of its absorbing strength uniformly along the length of the rod. The rod is fail safe and is fully inserted into the core but changes in its absorbing strength do not produce axial flux distortion. The control device comprises a sheet containing a material having a high thermal-neutron absorption cross section. A pair of shafts engage the sheet along the longitudinal axis of the shafts and gears associated with the shafts permit winding and unwinding of the sheet around the shafts.

  12. Control rod drive hydraulic system

    DOEpatents

    Ose, Richard A.

    1992-01-01

    A hydraulic system for a control rod drive (CRD) includes a variable output-pressure CR pump operable in a charging mode for providing pressurized fluid at a charging pressure, and in a normal mode for providing the pressurized fluid at a purge pressure, less than the charging pressure. Charging and purge lines are disposed in parallel flow between the CRD pump and the CRD. A hydraulic control unit is disposed in flow communication in the charging line and includes a scram accumulator. An isolation valve is provided in the charging line between the CRD pump and the scram accumulator. A controller is operatively connected to the CRD pump and the isolation valve and is effective for opening the isolation valve and operating the CRD pump in a charging mode for charging the scram accumulator, and closing the isolation valve and operating the CRD pump in a normal mode for providing to the CRD through the purge line the pressurized fluid at a purge pressure lower than the charging pressure.

  13. Taylor impact of glass rods

    SciTech Connect

    Willmott, G.R.; Radford, D.D.

    2005-05-01

    The deformation and fracture behavior of soda-lime and borosilicate glass rods was examined during classic and symmetric Taylor impact experiments for impact pressures to 4 and 10 GPa, respectively. High-speed photography and piezoresistive gauges were used to measure the failure front velocities in both glasses, and for impact pressures below {approx}2 GPa the failure front velocity increases rapidly with increasing pressure. As the pressure was increased above {approx}3 GPa, the failure front velocities asymptotically approached maximum values between the longitudinal and shear wave velocities of each material; at {approx}4 GPa, the average failure front velocities were 4.7{+-}0.5 and 4.6{+-}0.5 mm {mu}s{sup -1} for the soda-lime and borosilicate specimens, respectively. The observed mechanism of failure in these experiments involved continuous pressure-dependent nucleation and growth of microcracks behind the incident wave. As the impact pressure was increased, there was a decrease in the time to failure. The density of cracks within the failed region was material dependent, with the more open-structured borosilicate glass showing a larger fracture density.

  14. A measurement of a control rod drop using an LVDT

    NASA Astrophysics Data System (ADS)

    Choi, Myoung-Hwan; Kim, Ji-Ho; Huh, Hyung; Yu, Je-Yong; Sohn, Dong-Seong

    2010-03-01

    A control element drive mechanism is a reactor regulating system, which is to insert, withdraw, or maintain a control rod containing neutron-absorbing material within a reactor core to control the reactivity of the reactor. The ball-screw type CEDM for the small and medium research reactor has a spring-hydraulic damper to reduce the impact force due to the free drop of the CEDM. This paper describes the experimental results to obtain the drop characteristics of the CEDM. The tests are performed by using a full-scale structure except the control element assembly, and a drop time and displacement after an impact are measured by using an LVDT. The influences of the rod weight and the drop height on the drop behavior are also estimated on the basis of test results. In case of the longest stroke, the drop time of the control rod is within 4.5 seconds to meet the design requirement. The behavior after the impact shows a general damping motion of the spring-damper system, and the maximum displacement is measured as 15.6 mm.

  15. A measurement of a control rod drop using an LVDT

    NASA Astrophysics Data System (ADS)

    Choi, Myoung-Hwan; Kim, Ji-Ho; Huh, Hyung; Yu, Je-Yong; Sohn, Dong-Seong

    2009-12-01

    A control element drive mechanism is a reactor regulating system, which is to insert, withdraw, or maintain a control rod containing neutron-absorbing material within a reactor core to control the reactivity of the reactor. The ball-screw type CEDM for the small and medium research reactor has a spring-hydraulic damper to reduce the impact force due to the free drop of the CEDM. This paper describes the experimental results to obtain the drop characteristics of the CEDM. The tests are performed by using a full-scale structure except the control element assembly, and a drop time and displacement after an impact are measured by using an LVDT. The influences of the rod weight and the drop height on the drop behavior are also estimated on the basis of test results. In case of the longest stroke, the drop time of the control rod is within 4.5 seconds to meet the design requirement. The behavior after the impact shows a general damping motion of the spring-damper system, and the maximum displacement is measured as 15.6 mm.

  16. Scaled Long Rod Penetration Experiments: Tungsten - RHA

    NASA Astrophysics Data System (ADS)

    Proud, William

    2011-06-01

    Scaled, reverse ballistic, long-rod experiments were performed at an impact velocity in the range of ~700 m s-1. The targets were tungsten alloy rods and the projectiles either 3 or 6 mm thick rolled homogeneous armour (RHA) plates. The plate was inclined at 30 to the direction of travel and the interaction was recorded using high-speed photography, strain gauges and laser velocimetry. The pitch of the rod was varied in steps of 3 over a total range of 15. In this range the rod deformation changed dramatically the bending process moved from a flexing of the tip away from the plate, to a marked motion into the surface. Cross comparison of the diagnostic outputs reveals the time windows for these process and also the varying sensitivity of the measurement system to that process. Post-impact recovery was also performed.

  17. Bouncing Balls and Hot Rod Races.

    ERIC Educational Resources Information Center

    Tibbs, Peggy; Sherrill, Donna

    This paper presents the Bouncing Ball Experiment which models quadratic and exponential functions, and the Hot Rod Races activity that explores velocity and acceleration. Activities include directions for the use of TI-82 and TI-83 calculators. (YDS)

  18. Control rod for a nuclear reactor

    DOEpatents

    Roman, Walter G.; Sutton, Jr., Harry G.

    1979-01-01

    A control rod assembly for a nuclear reactor is disclosed having a remotely disengageable coupling between the control rod and the control rod drive shaft. The coupling is actuated by first lowering then raising the drive shaft. The described motion causes axial repositioning of a pin in a grooved rotatable cylinder, each being attached to different parts of the drive shaft which are axially movable relative to each other. In one embodiment, the relative axial motion of the parts of the drive shaft is used either to couple or to uncouple the connection by forcing resilient members attached to the drive shaft into or out of shouldered engagement, respectively, with an indentation formed in the control rod.

  19. Laser-assisted growth of molybdenum rods

    NASA Astrophysics Data System (ADS)

    Björklund, K. L.; Heszler, P.; Boman, M.

    2002-01-01

    In this paper, we report for the first time the laser-assisted growth of molybdenum rods via the H 2 reduction of MoF 6 with a focused Ar + laser beam as the heat source. By varying the gas composition, total pressure, and laser power rods with different morphologies were deposited on a tungsten wire. At low H 2/MoF 6 molar ratios crystal-like rods were obtained and at higher molar ratios the rods became dendrite-like. The activation energy for the process was determined to be 77±7 kJ mol -1 in the temperature range 705-840 K. The reaction order showed to be nearly 3 with respect to the hydrogen partial pressure and zero order with respect to the molybdenum hexafluoride partial pressure. Compositional and morphological characterisation were performed with scanning electron microscopy, energy dispersed X-ray spectroscopy and Auger electron spectroscopy.

  20. Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors.

    PubMed

    Akimoto, Masayuki; Cheng, Hong; Zhu, Dongxiao; Brzezinski, Joseph A; Khanna, Ritu; Filippova, Elena; Oh, Edwin C T; Jing, Yuezhou; Linares, Jose-Luis; Brooks, Matthew; Zareparsi, Sepideh; Mears, Alan J; Hero, Alfred; Glaser, Tom; Swaroop, Anand

    2006-03-07

    The Maf-family transcription factor Nrl is a key regulator of photoreceptor differentiation in mammals. Ablation of the Nrl gene in mice leads to functional cones at the expense of rods. We show that a 2.5-kb Nrl promoter segment directs the expression of enhanced GFP specifically to rod photoreceptors and the pineal gland of transgenic mice. GFP is detected shortly after terminal cell division, corresponding to the timing of rod genesis revealed by birthdating studies. In Nrl-/- retinas, the GFP+ photoreceptors express S-opsin, consistent with the transformation of rod precursors into cones. We report the gene profiles of freshly isolated flow-sorted GFP+ photoreceptors from wild-type and Nrl-/- retinas at five distinct developmental stages. Our results provide a framework for establishing gene regulatory networks that lead to mature functional photoreceptors from postmitotic precursors. Differentially expressed rod and cone genes are excellent candidates for retinopathies.

  1. Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors

    PubMed Central

    Akimoto, Masayuki; Cheng, Hong; Zhu, Dongxiao; Brzezinski, Joseph A.; Khanna, Ritu; Filippova, Elena; Oh, Edwin C. T.; Jing, Yuezhou; Linares, Jose-Luis; Brooks, Matthew; Zareparsi, Sepideh; Mears, Alan J.; Hero, Alfred; Glaser, Tom; Swaroop, Anand

    2006-01-01

    The Maf-family transcription factor Nrl is a key regulator of photoreceptor differentiation in mammals. Ablation of the Nrl gene in mice leads to functional cones at the expense of rods. We show that a 2.5-kb Nrl promoter segment directs the expression of enhanced GFP specifically to rod photoreceptors and the pineal gland of transgenic mice. GFP is detected shortly after terminal cell division, corresponding to the timing of rod genesis revealed by birthdating studies. In Nrl−/− retinas, the GFP+ photoreceptors express S-opsin, consistent with the transformation of rod precursors into cones. We report the gene profiles of freshly isolated flow-sorted GFP+ photoreceptors from wild-type and Nrl−/− retinas at five distinct developmental stages. Our results provide a framework for establishing gene regulatory networks that lead to mature functional photoreceptors from postmitotic precursors. Differentially expressed rod and cone genes are excellent candidates for retinopathies. PMID:16505381

  2. Double-clad nuclear fuel safety rod

    DOEpatents

    McCarthy, William H.; Atcheson, Donald B.; Vaidyanathan, Swaminathan

    1984-01-01

    A device for shutting down a nuclear reactor during an undercooling or overpower event, whether or not the reactor's scram system operates properly. This is accomplished by double-clad fuel safety rods positioned at various locations throughout the reactor core, wherein melting of a secondary internal cladding of the rod allows the fuel column therein to shift from the reactor core to place the reactor in a subcritical condition.

  3. Microelectrophoresis of Silica Rods Using Confocal Microscopy

    PubMed Central

    2017-01-01

    The electrophoretic mobility and the zeta potential (ζ) of fluorescently labeled colloidal silica rods, with an aspect ratio of 3.8 and 6.1, were determined with microelectrophoresis measurements using confocal microscopy. In the case where the colloidal particles all move at the same speed parallel to the direction of the electric field, we record a xyz-stack over the whole depth of the capillary. This method is faster and more robust compared to taking xyt-series at different depths inside the capillary to obtain the parabolic flow profile, as was done in previous work from our group. In some cases, rodlike particles do not move all at the same speed in the electric field, but exhibit a velocity that depends on the angle between the long axis of the rod and the electric field. We measured the orientation-dependent velocity of individual silica rods during electrophoresis as a function of κa, where κ–1 is the double layer thickness and a is the radius of the rod associated with the diameter. Thus, we determined the anisotropic electrophoretic mobility of the silica rods with different sized double layers. The size of the double layer was tuned by suspending silica rods in different solvents at different electrolyte concentrations. We compared these results with theoretical predictions. We show that even at already relatively high κa when the Smoluchowski limiting law is assumed to be valid (κa > 10), an orientation dependent velocity was measured. Furthermore, we observed that at decreasing values of κa the anisotropy in the electrophoretic mobility of the rods increases. However, in low polar solvents with κa < 1, this trend was reversed: the anisotropy in the electrophoretic mobility of the rods decreased. We argue that this decrease is due to end effects, which was already predicted theoretically. When end effects are not taken into account, this will lead to strong underestimation of the experimentally determined zeta potential. PMID:28045541

  4. Calculator program speeds rod pump design

    SciTech Connect

    Engineer, R.; Davis, C.L.

    1984-02-01

    Matching sucker rod pump characteristics to a specific application is greatly simplified with this program, intended for use with an HP-41CV hand-held computer. The user inputs application data and the program calculates all necessary design criteria, including Mill's acceleration factor, peak and minimum polish rod loads and horsepower required. Sample calculations are provided, together with a thorough discussion of special design considerations involved in huff-and-puff applications.

  5. Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: Facts and models

    PubMed Central

    Korenbrot, Juan I.

    2012-01-01

    The light responses of rod and cone photoreceptors in the vertebrate retina are quantitatively different, yet extremely stable and reproducible because of the extraordinary regulation of the cascade of enzymatic reactions that link photon absorption and visual pigment excitation to the gating of cGMP-gated ion channels in the outer segment plasma membrane. While the molecular scheme of the phototransduction pathway is essentially the same in rods and cones, the enzymes and protein regulators that constitute the pathway are distinct. These enzymes and regulators can differ in the quantitative features of their functions or in concentration if their functions are similar or both can be true. The molecular identity and distinct function of the molecules of the transduction cascade in rods and cones are summarized. The functional significance of these molecular differences is examined with a mathematical model of the signal-transducing enzymatic cascade. Constrained by available electrophysiological, biochemical and biophysical data, the model simulates photocurrents that match well the electrical photoresponses measured in both rods and cones. Using simulation computed with the mathematical model, the time course of light-dependent changes in enzymatic activities and second messenger concentrations in non-mammalian rods and cones are compared side by side. PMID:22658984

  6. Measurements of control rod efficiency in RBMK critical assembly upon dropping of the rods

    NASA Astrophysics Data System (ADS)

    Zhitarev, V. E.; Kachanov, V. M.; Sergevnin, A. Yu.; Lebedev, G. V.

    2014-12-01

    The efficiency of control rods in the RBMK critical assembly was measured in the case where one manual-control rod (MCR) is dropped from a steady critical state, and several other MCRs were additionally dropped after 44 s. The measured number of neutrons in the assembly during and after dropping of the rods was used to calculate the efficiency values of the rods by solution of the system of point kinetics equations. A series of methods of the initial data treatment for determination of the desired values of reactivity without the calculated corrections were used.

  7. Measurements of control rod efficiency in RBMK critical assembly upon dropping of the rods

    SciTech Connect

    Zhitarev, V. E. Kachanov, V. M.; Sergevnin, A. Yu.; Lebedev, G. V.

    2014-12-15

    The efficiency of control rods in the RBMK critical assembly was measured in the case where one manual-control rod (MCR) is dropped from a steady critical state, and several other MCRs were additionally dropped after 44 s. The measured number of neutrons in the assembly during and after dropping of the rods was used to calculate the efficiency values of the rods by solution of the system of point kinetics equations. A series of methods of the initial data treatment for determination of the desired values of reactivity without the calculated corrections were used.

  8. Close packing of rods on spherical surfaces

    NASA Astrophysics Data System (ADS)

    Smallenburg, Frank; Löwen, Hartmut

    2016-04-01

    We study the optimal packing of short, hard spherocylinders confined to lie tangential to a spherical surface, using simulated annealing and molecular dynamics simulations. For clusters of up to twelve particles, we map out the changes in the geometry of the closest-packed configuration as a function of the aspect ratio L/D, where L is the cylinder length and D the diameter of the rods. We find a rich variety of cluster structures. For larger clusters, we find that the best-packed configurations up to around 100 particles are highly dependent on the exact number of particles and aspect ratio. For even larger clusters, we find largely disordered clusters for very short rods (L/D = 0.25), while slightly longer rods (L/D = 0.5 or 1) prefer a global baseball-like geometry of smectic-like domains, similar to the behavior of large-scale nematic shells. Intriguingly, we observe that when compared to their optimal flat-plane packing, short rods adapt to the spherical geometry more efficiently than both spheres and longer rods. Our results provide predictions for experimentally realizable systems of colloidal rods trapped at the interface of emulsion droplets.

  9. Epigenomic landscapes of retinal rods and cones

    PubMed Central

    Mo, Alisa; Luo, Chongyuan; Davis, Fred P; Mukamel, Eran A; Henry, Gilbert L; Nery, Joseph R; Urich, Mark A; Picard, Serge; Lister, Ryan; Eddy, Sean R; Beer, Michael A; Ecker, Joseph R; Nathans, Jeremy

    2016-01-01

    Rod and cone photoreceptors are highly similar in many respects but they have important functional and molecular differences. Here, we investigate genome-wide patterns of DNA methylation and chromatin accessibility in mouse rods and cones and correlate differences in these features with gene expression, histone marks, transcription factor binding, and DNA sequence motifs. Loss of NR2E3 in rods shifts their epigenomes to a more cone-like state. The data further reveal wide differences in DNA methylation between retinal photoreceptors and brain neurons. Surprisingly, we also find a substantial fraction of DNA hypo-methylated regions in adult rods that are not in active chromatin. Many of these regions exhibit hallmarks of regulatory regions that were active earlier in neuronal development, suggesting that these regions could remain undermethylated due to the highly compact chromatin in mature rods. This work defines the epigenomic landscapes of rods and cones, revealing features relevant to photoreceptor development and function. DOI: http://dx.doi.org/10.7554/eLife.11613.001 PMID:26949250

  10. High-throughput rod-induced electrospinning

    NASA Astrophysics Data System (ADS)

    Wu, Dezhi; Xiao, Zhiming; Teh, Kwok Siong; Han, Zhibin; Luo, Guoxi; Shi, Chuan; Sun, Daoheng; Zhao, Jinbao; Lin, Liwei

    2016-09-01

    A high throughput electrospinning process, directly from flat polymer solution surfaces induced by a moving insulating rod, has been proposed and demonstrated. Different rods made of either phenolic resin or paper with a diameter of 1-3 cm and a resistance of about 100-500 MΩ, has been successfully utilized in the process. The rod is placed approximately 10 mm above the flat polymer solution surface with a moving speed of 0.005-0.4 m s-1 this causes the solution to generate multiple liquid jets under an applied voltage of 15-60 kV for the tip-less electrospinning process. The local electric field induced by the rod can boost electrohydrodynamic instability in order to generate Taylor cones and liquid jets. Experimentally, it is found that a large rod diameter and a small solution-to-rod distance can enhance the local electrical field to reduce the magnitude of the applied voltage. In the prototype setup with poly (ethylene oxide) polymer solution, an area of 5 cm  ×  10 cm and under an applied voltage of 60 kV, the maximum throughput of nanofibers is recorded to be approximately144 g m-2 h-1.

  11. Long-Rod Moving-Plate Interaction

    NASA Astrophysics Data System (ADS)

    Partom, Y.

    2002-07-01

    Understanding the mechanics of interaction of a long rod projectile with a forward moving plate at an angle is essential to understanding long rod interaction with an explosive reactive armor cassette. To investigate the mechanics of such an interaction we use AUTODIN2D/EULER in plane geometry, although the problem is 3D. We assume that this is a satisfactory approximation, as we're only interested in the main features, and are not comparing fine details to experimental results. From the simulations we learn that the interaction never reaches steady state. Initially each material splits into two streams, and the interaction plane is perpendicular to the rod. But with time the interaction plane rotates slowly, until it becomes parallel to the rod, which is then able to continue moving forward without interruption. During this process interacting rod material of length DeltaL is diverted at an angle and becomes ineffective for penetrating the main target. We made many such runs to determine the dependence of DeltaL on the parameters of the problem. This dependence makes it possible to predict DeltaL for a variety of rod-plate situations.

  12. Long-Rod Moving-Plate Interaction

    NASA Astrophysics Data System (ADS)

    Partom, Yehuda

    2001-06-01

    Understanding the mechanics of interaction of a long rod projectile with a forward moving plate at an angle is essential to understanding long rod interaction with an explosive reactive armor cassette. To investigate the mechanics of such an interaction we use AUTODYN2D/Euler in planar symmetry, although the problem is 3D. We assume that this is a good enough approximation, as we're only interested in the main features, and are not comparing fine detailes to experimental results. From the simulations we learn that the interaction never reaches steady state. Initially, each material splits into two streams, and the interaction plane is perpendicular to the rod. But with time, the interaction plane rotates slowly until it becomes parallel to the rod, which is then able to continue moving forward without interruption. During this process, interacting rod material of length dL is diverted at an angle and becomes ineffective for penetrating the main target. We made many such runs to determine the dependence of dL on the material and kinematic parameters of the problem. This dependence makes it possible to predict dL for a variaty of rod-plate situations.

  13. Rigid rod anchored to infinite membrane.

    PubMed

    Guo, Kunkun; Qiu, Feng; Zhang, Hongdong; Yang, Yuliang

    2005-08-15

    We investigate the shape deformation of an infinite membrane anchored by a rigid rod. The density profile of the rod is calculated by the self-consistent-field theory and the shape of the membrane is predicted by the Helfrich membrane elasticity theory [W. Helfrich, Z. Naturforsch. 28c, 693 (1973)]. It is found that the membrane bends away from the rigid rod when the interaction between the rod and the membrane is repulsive or weakly attractive (adsorption). However, the pulled height of the membrane at first increases and then decreases with the increase of the adsorption strength. Compared to a Gaussian chain with the same length, the rigid rod covers much larger area of the membrane, whereas exerts less local entropic pressure on the membrane. An evident gap is found between the membrane and the rigid rod because the membrane's curvature has to be continuous. These behaviors are compared with that of the flexible-polymer-anchored membranes studied by previous Monte Carlo simulations and theoretical analysis. It is straightforward to extend this method to more complicated and real biological systems, such as infinite membrane/multiple chains, protein inclusion, or systems with phase separation.

  14. International symposium on fuel rod simulators: development and application

    SciTech Connect

    McCulloch, R.W.

    1981-05-01

    Separate abstracts are included for each of the papers presented concerning fuel rod simulator operation and performance; simulator design and evaluation; clad heated fuel rod simulators and fuel rod simulators for cladding investigations; fuel rod simulator components and inspection; and simulator analytical modeling. Ten papers have previously been input to the Energy Data Base.

  15. Nuclear reactor remote disconnect control rod coupling indicator

    DOEpatents

    Vuckovich, Michael

    1977-01-01

    A coupling indicator for use with nuclear reactor control rod assemblies which have remotely disengageable couplings between the control rod and the control rod drive shaft. The coupling indicator indicates whether the control rod and the control rod drive shaft are engaged or disengaged. A resistive network, utilizing magnetic reed switches, senses the position of the control rod drive mechanism lead screw and the control rod position indicating tube, and the relative position of these two elements with respect to each other is compared to determine whether the coupling is engaged or disengaged.

  16. Photovoltage of Rods and Cones in the Macaque Retina

    NASA Astrophysics Data System (ADS)

    Schneeweis, David M.; Schnapf, Julie L.

    1995-05-01

    The kinetics, gain, and reliability of light responses of rod and cone photoreceptors are important determinants of overall visual sensitivity. In voltage recordings from photoreceptors in an intact primate retina, rods were found to be functionally isolated from each other, unlike the tightly coupled rods of cold-blooded vertebrates. Cones were observed to receive excitatory input from rods, which indicates that the cone pathway also processes rod signals. This input might be expected to degrade the spatial resolution of mesopic vision.

  17. Regulatory perspective on incomplete control rod insertions

    SciTech Connect

    Chatterton, M.

    1997-01-01

    The incomplete control rod insertions experienced at South Texas Unit 1 and Wolf Creek are of safety concern to the NRC staff because they represent potential precursors to loss of shutdown margin. Even before it was determined if these events were caused by the control rods or by the fuel there was an apparent correlation of the problem with high burnup fuel. It was determined that there was also a correlation between high burnup and high drag forces as well as with rod drop time histories and lack of rod recoil. The NRC staff initial actions were aimed at getting a perspective on the magnitude of the problem as far as the number of plants and the amount of fuel that could be involved, as well as the safety significance in terms of shutdown margin. As tests have been performed and data has been analyzed the focus has shifted more toward understanding the problem and the ways to eliminate it. At this time the staff`s understanding of the phenomena is that it was a combination of factors including burnup, power history and temperature. The problem appears to be very sensitive to these factors, the interaction of which is not clearly understood. The model developed by Westinghouse provides a possible explanation but there is not sufficient data to establish confidence levels and sensitivity studies involving the key parameters have not been done. While several fixes to the problem have been discussed, no definitive fixes have been proposed. Without complete understanding of the phenomena, or fixes that clearly eliminate the problem the safety concern remains. The safety significance depends on the amount of shutdown margin lost due to incomplete insertion of the control rods. Were the control rods to stick high in the core, the reactor could not be shutdown by the control rods and other means such as emergency boration would be required.

  18. Effects of rod worth and drop speed on the BWR off-center rod drop accident

    SciTech Connect

    Cokinos, D.M.; Carew, J.F.

    1986-01-01

    The purpose of the present study was to determine the effect of increasing the control rod worth and the rod drop speed on the off-center RDA. An increase in either of these parameters results in an increase in peak core power and fuel enthalpy, and the objective of this study is to determine the margin to the fuel damage threshold.

  19. Dissipative particle dynamics simulations on self-assembly of rod-coil-rod triblock copolymers in a rod-selective solvent

    NASA Astrophysics Data System (ADS)

    Huang, Jian-Hua; Fan, Zhong-Xiang; Ma, Ze-Xin

    2013-08-01

    Self-assembly of rod-coil-rod ABA triblock copolymers in a rod-selective solvent is investigated by using dissipative particle dynamics simulations. The morphologies of the self-assembled aggregates are dependent on the number of copolymers in the aggregate and the rod length of the copolymer. We observe vesicles at short rod block and bowl-like aggregates at slightly longer rod block. In the vesicle region near the phase boundary, metastable bowl-like aggregates can be observed and be transformed into vesicles by annealing process. A transition from the bowl-like structure to the vesicle is observed by increasing the solvophobicity of the mid-coil block. In this study, the difference between the self-assembly of fully flexible ABA triblock copolymer and that of rod-coil-rod triblock copolymer is also discussed.

  20. Transduction heats in retinal rods: tests of the role of cGMP by pyroelectric calorimetry.

    PubMed Central

    Hagins, W A; Ross, P D; Tate, R L; Yoshikami, S

    1989-01-01

    The sensory dark current of vertebrate retinal rods is believed to be controlled by light activation of a chain of coupled biochemical cycles that finally regulate the cationic conductance of the plasma membrane by hydrolytically reducing the level of cGMP in rod outer segment cytoplasm. The scheme has been tested by measuring heat production by live frog retinas when stimulated with sequences of light flashes of progressively increasing energy. Using pyroelectric poly(vinylidene 1,1-difluoride) detectors that simultaneously measure transretinal voltage and retinal temperature change, four heat effects assignable to known biochemical cycles in rods have been found. As the dark current shuts down after a flash causing 180-1800 rhodopsin photoisomerizations per rod, a heat burst, q1, raises the retinal temperature 1-2 microK. q1 is closely regulated in size and slightly precedes dark current shutdown. Isobutylmethylxanthine slows and enlarges q1, delaying the dark-current response. Increasing cytoplasmic Ca2+ stops the dark current without affecting q1. Although rod heat production is consistent with splitting of 1-3 microM of free cytoplasmic cGMP during transduction, the kinetics of the two processes do not match the predictions of current cGMP control models. PMID:2537492

  1. Particle-rod hybrids: growth of arachidic acid molecular rods from capped cadmium selenide nanoparticles.

    PubMed

    Chen, Dongzhong; Wang, Ruomiao; Arachchige, Indika; Mao, Guangzhao; Brock, Stephanie L

    2004-12-22

    This communication describes a spin-coating method to nucleate organic molecular rods of uniform size from an inorganic nanoparticle at a solid surface. The particle-rod hybrid structure spontaneously forms when a film is spin coated from a mixed 2-propanol solution of arachidic acid (AA) and nanoparticles of cadmium selenide capped by mercaptoundecanoic acid (MUA-CdSe) on graphite. AFM images show that MUA-CdSe nanoparticles nucleate single crystalline rods of AA with a cross section of a single unit cell of the C-form. The solution-based process potentially allows the precise tuning of the wetting profile of the solution on the surface-attached nanoparticle, which provides the reservoir for the growth of the single crystalline rods. The results suggest that nanoparticles can be regarded as nanoseeds for the nucleation of guest crystals. It should be possible to further functionalize the AA rods by electrostatic complexation with metal or organic ions.

  2. New rod-plate anterior instrumentation for thoracolumbar/lumbar scoliosis: biomechanical evaluation compared with dual-rod and single-rod with structural interbody support.

    PubMed

    Zhang, Hong; Johnston, Charles E; Pierce, William A; Ashman, Richard B; Bronson, Dwight G; Haideri, Nessie F

    2006-12-01

    A new rod-plate anterior implant was designed to provide plate fixation at the cephalad and caudal-end segments of a 5-level anterior spine construct. Biomechanical testing was performed on calf spines instrumented with 5-segment anterior scoliosis constructs. OBJECTIVES.: To analyze the initial and post-fatigue biomechanical performance of the new implant, and compare it to an anterior dual-rod construct and a single-rod construct with interbody cages. Using single-rod anterior instrumentation for thoracolumbar and lumbar scoliosis, an unacceptable incidence of loss of correction, segmental kyphosis, and pseudarthrosis has been reported. Inadequate construct stiffness due to early postoperative bone-screw interface failure, especially at cephalad and caudal-end vertebrae, has been implicated as the cause of these complications. Thirty calf spines were instrumented over 5 segments with: (1) single-rod augmented with rod-plate implants, (2) dual-rod construct, and (3) single-rod with titanium mesh cages. Stiffness in flexion-extension and lateral bending modes was determined initially and post-cyclical loading by measuring segmental range of motion (ROM). Post-fatigue screw pullout tests were also performed. In lateral bending, the caudal-end segmental ROM for rod-plate construct was 54% less than single-rod with cages construct (P < 0.05), with no difference between rod-plate and dual-rod constructs. In flexion-extension, the rod-plate construct showed 45% to 91% (initial test) and 84% to 90% (post-fatigue) less ROM than the single-rod with cages construct (P < 0.001). Again, there was no difference between rod-plate and dual-rod constructs at the cephalad and caudal-end segments. Post-fatigue screw pullout strengths of the rod-plate construct were significantly greater than those of the dual-rod and single-rod with cages constructs (P < 0.05). The rod-plate construct was significantly stiffer and provided greater stability of bone-screw interface than the single-rod

  3. Bent Telescopic Rods in Patients With Osteogenesis Imperfecta.

    PubMed

    Lee, R Jay; Paloski, Michael D; Sponseller, Paul D; Leet, Arabella I

    2016-09-01

    Telescopic rods require alignment of 2 rods to enable lengthening. A telescopic rod converts functionally into a solid rod if either rod bends, preventing proper engagement. Our goal was to characterize implant bending as a mode of failure of telescopic rods used in the treatment of osteogenesis imperfecta in children. We conducted a retrospective review of our osteogenesis imperfecta database for patients treated with intramedullary telescopic rods at our institution from 1992 through 2010 and identified 12 patients with bent rods. The 6 boys and 6 girls had an average age at the time of initial surgery of 3.1 years (range, 1.8 to 8.3 y) and a total of 51 telescoping rods. Clinic notes, operative reports, and radiographs were reviewed. The rods were analyzed for amount of lengthening, characteristics of bending, presence of cut out, or disengagement from an anchor point. Bends in the rods were characterized by their location on the implant component. The bent and straight rods were compared. Data were analyzed with the Mann-Whitney test (statistical significance set at P≤0.05). Of the 51 telescoping rods, 17 constructs (33%) bent. The average interval between surgery and rod bending was 4.0 years (range, 0.9 to 8.2 y). Before bending, 11 of 17 telescoping rods had routine follow-up radiographs for review. In 10 of the rods, bending was present when early signs of rod failure were first detected. Rod bending did not seem to be related to rod size. There was no area on the rod itself that seemed more susceptible to bending. Rod bending can be an early sign of impending rod failure. When rod bending is first noted, it may predispose the rod to other subsequent failures such as loss of proximal and distal fixation and cut out. Rod bending should be viewed as an indicator for closer monitoring of the patient and discussions regarding future need for rod exchange. Level III-retrospective review.

  4. Coiling of elastic rods on rigid substrates

    PubMed Central

    Jawed, Mohammad K.; Da, Fang; Joo, Jungseock; Grinspun, Eitan; Reis, Pedro M.

    2014-01-01

    We investigate the deployment of a thin elastic rod onto a rigid substrate and study the resulting coiling patterns. In our approach, we combine precision model experiments, scaling analyses, and computer simulations toward developing predictive understanding of the coiling process. Both cases of deposition onto static and moving substrates are considered. We construct phase diagrams for the possible coiling patterns and characterize them as a function of the geometric and material properties of the rod, as well as the height and relative speeds of deployment. The modes selected and their characteristic length scales are found to arise from a complex interplay between gravitational, bending, and twisting energies of the rod, coupled to the geometric nonlinearities intrinsic to the large deformations. We give particular emphasis to the first sinusoidal mode of instability, which we find to be consistent with a Hopf bifurcation, and analyze the meandering wavelength and amplitude. Throughout, we systematically vary natural curvature of the rod as a control parameter, which has a qualitative and quantitative effect on the pattern formation, above a critical value that we determine. The universality conferred by the prominent role of geometry in the deformation modes of the rod suggests using the gained understanding as design guidelines, in the original applications that motivated the study. PMID:25267649

  5. Wetting of a partially immersed compliant rod

    NASA Astrophysics Data System (ADS)

    Hui, Chung-Yuen; Jagota, Anand

    2016-11-01

    The force on a solid rod partially immersed in a liquid is commonly used to determine the liquid-vapor surface tension by equating the measured force required to remove the rod from the liquid to the vertical component of the liquid-vapor surface tension. Here, we study how this process is affected when the rod is compliant. For equilibrium, we enforce force and configurational energy balance, including contributions from elastic energy. We show that, in general, the contact angle does not equal that given by Young's equation. If surface stresses are tensile, the strain in the immersed part of the rod is found to be compressive and to depend only on the solid-liquid surface stress. The strain in the dry part of the rod can be either tensile or compressive, depending on a combination of parameters that we identify. We also provide results for compliant plates partially immersed in a liquid under plane strain and plane stress. Our results can be used to extract solid surface stresses from such experiments.

  6. Gelation And Mechanical Response of Patchy Rods

    NASA Astrophysics Data System (ADS)

    Kazem, Navid; Majidi, Carmel; Maloney, Craig

    We perform Brownian Dynamics simulations to study the gelation of suspensions of attractive, rod-like particles. We show that details of the particle-particle interactions can dramatically affect the dynamics of gelation and the structure and mechanics of the networks that form. If the attraction between the rods is perfectly smooth along their length, they will collapse into compact bundles. If the attraction is sufficiently corrugated or patchy, over time, a rigid space spanning network forms. We study the structure and mechanical properties of the networks that form as a function of the fraction of the surface that is allowed to bind. Surprisingly, the structural and mechanical properties are non-monotonic in the surface coverage. At low coverage, there are not a sufficient number of cross-linking sites to form networks. At high coverage, rods bundle and form disconnected clusters. At intermediate coverage, robust networks form. The elastic modulus and yield stress are both non-monotonic in the surface coverage. The stiffest and strongest networks show an essentially homogeneous deformation under strain with rods re-orienting along the extensional axis. Weaker, clumpy networks at high surface coverage exhibit relatively little re-orienting with strong non-affine deformation. These results suggest design strategies for tailoring surface interactions between rods to yield rigid networks with optimal properties. National Science Foundation and the Air Force Office of Scientific Research.

  7. Radiological characterization of spent control rod assemblies

    SciTech Connect

    Lepel, E.A.; Robertson, D.E.; Thomas, C.W.; Pratt, S.L.; Haggard, D.L.

    1995-10-01

    This document represents the final report of an ongoing study to provide radiological characterizations, classifications, and assessments in support of the decommissioning of nuclear power stations. This report describes the results of non-destructive and laboratory radionuclide measurements, as well as waste classification assessments, of BWR and PWR spent control rod assemblies. The radionuclide inventories of these spent control rods were determined by three separate methodologies, including (1) direct assay techniques, (2) calculational techniques, and (3) by sampling and laboratory radiochemical analyses. For the BWR control rod blade (CRB) and PWR burnable poison rod assembly (BPRA), {sup 60}Co and {sup 63}Ni, present in the stainless steel cladding, were the most abundant neutron activation products. The most abundant radionuclide in the PWR rod cluster control assembly (RCCA) was {sup 108m}Ag (130 yr halflife) produced in the Ag-In-Cd alloy used as the neutron poison. This radionuclide will be the dominant contributor to the gamma dose rate for many hundreds of years. The results of the direct assay methods agree very well ({+-}10%) with the sampling/radiochemical measurements. The results of the calculational methods agreed fairly well with the empirical measurements for the BPRA, but often varied by a factor of 5 to 10 for the CRB and the RCCA assemblies. If concentration averaging and encapsulation, as allowed by 10CFR61.55, is performed, then each of the entire control assemblies would be classified as Class C low-level radioactive waste.

  8. Passive electrical properties of rod outer segments

    PubMed Central

    Falk, Gertrude; Fatt, P.

    1968-01-01

    1. Measurements on a packed suspension of randomly oriented, dark-adapted frog rods at frequencies of 15 c/s-0·5 Mc/s indicate a behaviour similar to that of other biological materials. 2. Results are analysed on the assumption that the low-frequency limiting resistance is determined by current flowing in the suspending medium and that, of the rods, two thirds are oriented perpendicular to the applied field and one third parallel to it. Those parallel to the field are treated as non-conductors. 3. From the high-frequency limiting resistance the conductivity of the rod interior is calculated to vary linearly with the conductivity of the medium. The slope of the relation of internal to external conductivity is 0·50 with a limiting internal conductivity (at zero external) of 280 μmho/cm. 4. On the assumption that the suspension can be represented as a single-capacitance network, the characteristic frequency of impedance is used to calculate a capacitance for the rod surface of 1·54 μF/cm2. On the assumption of a distribution in properties of the suspension according to the theory of Bruggeman, the capacitance is calculated to have a value of about one half this. 5. At frequencies below 5 kc/s the impedance locus deviates from the curve describing the behaviour at higher frequencies. It is suggested that this may involve conduction in a thin layer extending along the surface of the rod. PMID:5685292

  9. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods

    PubMed Central

    Nymark, Soile; Kolesnikov, Alexander V.; Berry, Justin D.; Adler, Leopold; Koutalos, Yiannis; Kefalov, Vladimir J.; Cornwall, M. Carter

    2016-01-01

    Photoactivation of vertebrate rhodopsin converts it to the physiologically active Meta II (R*) state, which triggers the rod light response. Meta II is rapidly inactivated by the phosphorylation of C-terminal serine and threonine residues by G-protein receptor kinase (Grk1) and subsequent binding of arrestin 1 (Arr1). Meta II exists in equilibrium with the more stable inactive form of rhodopsin, Meta III. Dark adaptation of rods requires the complete thermal decay of Meta II/Meta III into opsin and all-trans retinal and the subsequent regeneration of rhodopsin with 11-cis retinal chromophore. In this study, we examine the regulation of Meta III decay by Grk1 and Arr1 in intact mouse rods and their effect on rod dark adaptation. We measure the rates of Meta III decay in isolated retinas of wild-type (WT), Grk1-deficient (Grk1−/−), Arr1-deficient (Arr1−/−), and Arr1-overexpressing (Arr1ox) mice. We find that in WT mouse rods, Meta III peaks ∼6 min after rhodopsin activation and decays with a time constant (τ) of 17 min. Meta III decay slows in Arr1−/− rods (τ of ∼27 min), whereas it accelerates in Arr1ox rods (τ of ∼8 min) and Grk1−/− rods (τ of ∼13 min). In all cases, regeneration of rhodopsin with exogenous 11-cis retinal is rate limited by the decay of Meta III. Notably, the kinetics of rod dark adaptation in vivo is also modulated by the levels of Arr1 and Grk1. We conclude that, in addition to their well-established roles in Meta II inactivation, Grk1 and Arr1 can modulate the kinetics of Meta III decay and rod dark adaptation in vivo. PMID:27353443

  10. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.

    PubMed

    Frederiksen, Rikard; Nymark, Soile; Kolesnikov, Alexander V; Berry, Justin D; Adler, Leopold; Koutalos, Yiannis; Kefalov, Vladimir J; Cornwall, M Carter

    2016-07-01

    Photoactivation of vertebrate rhodopsin converts it to the physiologically active Meta II (R*) state, which triggers the rod light response. Meta II is rapidly inactivated by the phosphorylation of C-terminal serine and threonine residues by G-protein receptor kinase (Grk1) and subsequent binding of arrestin 1 (Arr1). Meta II exists in equilibrium with the more stable inactive form of rhodopsin, Meta III. Dark adaptation of rods requires the complete thermal decay of Meta II/Meta III into opsin and all-trans retinal and the subsequent regeneration of rhodopsin with 11-cis retinal chromophore. In this study, we examine the regulation of Meta III decay by Grk1 and Arr1 in intact mouse rods and their effect on rod dark adaptation. We measure the rates of Meta III decay in isolated retinas of wild-type (WT), Grk1-deficient (Grk1(-/-)), Arr1-deficient (Arr1(-/-)), and Arr1-overexpressing (Arr1(ox)) mice. We find that in WT mouse rods, Meta III peaks ∼6 min after rhodopsin activation and decays with a time constant (τ) of 17 min. Meta III decay slows in Arr1(-/-) rods (τ of ∼27 min), whereas it accelerates in Arr1(ox) rods (τ of ∼8 min) and Grk1(-/-) rods (τ of ∼13 min). In all cases, regeneration of rhodopsin with exogenous 11-cis retinal is rate limited by the decay of Meta III. Notably, the kinetics of rod dark adaptation in vivo is also modulated by the levels of Arr1 and Grk1. We conclude that, in addition to their well-established roles in Meta II inactivation, Grk1 and Arr1 can modulate the kinetics of Meta III decay and rod dark adaptation in vivo. © 2016 Frederiksen et al.

  11. Rod consolidation at the West Valley Demonstration Project

    SciTech Connect

    Bailey, W.J.

    1986-12-01

    A rod consolidation demonstration with irradiated pressurized water reactor fuel was recently conducted by personnel from Nuclear Assurance Corporation and West Valley Nuclear Services Company at the West Valley Demonstration Project in West Valley, New York. The rod consolidation demonstration involved pulling all of the fuel rods from six fuel Assemblies. In general, the rod pulling proceeded smoothly. The highest compaction ratio attained was 1:8:1. Among the total of 1074 fuel rods were some known degraded rods (they had collapsed cladding, a result of in-reactor fuel densification), but no rods were broken or dropped during the demonstration. One aim was to gather information on the effect of rod consolidation operations on the integrity of the fuel rods during subsequent handling and storage. Another goal was to collect information on the condition and handling of intact, damaged, and failed fuel that has been in storage for an extended period. 9 refs., 8 figs., 1 tab.

  12. Magnetic switch for reactor control rod. [LMFBR

    DOEpatents

    Germer, J.H.

    1982-09-30

    A magnetic reed switch assembly is described for activating an electromagnetic grapple utilized to hold a control rod in position above a reactor core. In normal operation the magnetic field of a permanent magnet is short-circuited by a magnetic shunt, diverting the magnetic field away from the reed switch. The magnetic shunt is made of a material having a Curie-point at the desired release temperature. Above that temperature the material loses its ferromagnetic properties, and the magnetic path is diverted to the reed switch which closes and short-circuits the control circuit for the control rod electro-magnetic grapple which allows the control rod to drop into the reactor core for controlling the reactivity of the core.

  13. Magnetic switch for reactor control rod

    DOEpatents

    Germer, John H.

    1986-01-01

    A magnetic reed switch assembly for activating an electromagnetic grapple utilized to hold a control rod in position above a reactor core. In normal operation the magnetic field of a permanent magnet is short-circuited by a magnetic shunt, diverting the magnetic field away from the reed switch. The magnetic shunt is made of a material having a Curie-point at the desired release temperature. Above that temperature the material loses its ferromagnetic properties, and the magnetic path is diverted to the reed switch which closes and short-circuits the control circuit for the control rod electromagnetic grapple which allows the control rod to drop into the reactor core for controlling the reactivity of the core.

  14. Concentration-dependent sedimentation of colloidal rods

    NASA Astrophysics Data System (ADS)

    Dogic, Z.; Philipse, A. P.; Fraden, S.; Dhont, J. K. G.

    2000-11-01

    In this paper we first develop an approximate theory for the leading order concentration dependence of the sedimentation coefficient for rodlike colloids/polymers/macromolecules. To first order in volume fraction φ of rods, the sedimentation coefficient is written as 1+αφ. For large aspect ratios L/D (L is the rod length, D its thickness) α is found to vary like ∝(L/D)2/ln(L/D). This theoretical prediction is compared to experimental results. Then, experiments on fd virus are described, both in the isotropic and nematic phase. First-order in concentration results for this very long and thin (semiflexible) rod are in agreement with the above-mentioned theoretical prediction. Sedimentation profiles for the nematic phase show two sedimentation fronts. This result indicates that the nematic phase becomes unstable with the respect to isotropic phase during sedimentation.

  15. Torque requirement of rotating rods in airflow

    NASA Technical Reports Server (NTRS)

    Barna, P. S.; Crossman, G. R.

    1979-01-01

    Experiments were performed to determine the torque required for rotating a rotor disk fitted with a number of radially arranged rods placed into a ducted airflow. An array of stationary rods, also radially arranged, was placed upstream close to the rotor with a small gap between the rods to cause wake interference. The results show that torque generally increased with airflow and the rate of increase varied considerably. At lower values of airflow, the rate of increase was larger than at higher airflow, and definite torque peaks occurred at certain airflow rates, where the torque attained a maximum within the test airflow range. During the test, a maximum blade passage frequency of 2037 Hz was attained. The results also show that the torque peaks occurred at the same Strouhal number for all speeds.

  16. Processing depleted uranium quad alloy penetrator rods

    SciTech Connect

    Bokan, S.L.

    1987-02-19

    Two depleted uranium (DU) quad alloys were cast, extruded and rolled to produce penetrator rods. The two alloy combinations were (1) 1 wt % molybdenum (Mo), 1 wt % niobium (Nb), and 0.75 wt % titanium (Ti); and (2) 1 wt % tantalum (Ta), 1 wt % Nb, and 0.75 wt % Ti. This report covers the processing and results with limited metallographic information available. The two alloys were each vacuum induction melted (VIM) into an 8-in. log, extruded into a 3-in. log, then cut into 4 logs and extruded at 4 different temperatures into 0.8-in. bars. From the 8 conditions (2 alloys, 4 extrusion temperatures each), 10 to 13 16-in. rods were cut for rolling and swaging. Due to cracking problems, the final processing changed from rolling and swaging to limited rolling and heat treating. The contracted work was completed with the delivery of 88 rods to Dr. Zabielski. 28 figs.

  17. Thermal modeling of W rod armor.

    SciTech Connect

    Nygren, Richard Einar

    2004-09-01

    Sandia has developed and tested mockups armored with W rods over the last decade and pioneered the initial development of W rod armor for International Thermonuclear Experimental Reactor (ITER) in the 1990's. We have also developed 2D and 3D thermal and stress models of W rod-armored plasma facing components (PFCs) and test mockups and are applying the models to both short pulses, i.e. edge localized modes (ELMs), and thermal performance in steady state for applications in C-MOD, DiMES testing and ITER. This paper briefly describes the 2D and 3D models and their applications with emphasis on modeling for an ongoing test program that simulates repeated heat loads from ITER ELMs.

  18. Self-Contact for Rods on Cylinders

    NASA Astrophysics Data System (ADS)

    van der Heijden, G. H. M.; Peletier, M. A.; Planqué, R.

    2006-11-01

    We study self-contact phenomena in elastic rods that are constrained to lie on a cylinder. By choosing a particular set of variables to describe the rod centerline the variational setting is made particularly simple: the strain energy is a second-order functional of a single scalar variable, and the self-contact constraint is written as an integral inequality. Using techniques from ordinary differential equation theory (comparison principles) and variational calculus (cut-and-paste arguments) we fully characterize the structure of constrained minimizers. An important auxiliary result states that the set of self-contact points is continuous, a result that contrasts with known examples from contact problems in free rods.

  19. Method for producing titanium aluminide weld rod

    DOEpatents

    Hansen, Jeffrey S.; Turner, Paul C.; Argetsinger, Edward R.

    1995-01-01

    A process for producing titanium aluminide weld rod comprising: attaching one end of a metal tube to a vacuum line; placing a means between said vacuum line and a junction of the metal tube to prevent powder from entering the vacuum line; inducing a vacuum within the tube; placing a mixture of titanium and aluminum powder in the tube and employing means to impact the powder in the tube to a filled tube; heating the tube in the vacuum at a temperature sufficient to initiate a high-temperature synthesis (SHS) reaction between the titanium and aluminum; and lowering the temperature to ambient temperature to obtain a intermetallic titanium aluminide alloy weld rod.

  20. Control rod drive for reactor shutdown

    DOEpatents

    McKeehan, Ernest R.; Shawver, Bruce M.; Schiro, Donald J.; Taft, William E.

    1976-01-20

    A means for rapidly shutting down or scramming a nuclear reactor, such as a liquid metal-cooled fast breeder reactor, and serves as a backup to the primary shutdown system. The control rod drive consists basically of an in-core assembly, a drive shaft and seal assembly, and a control drive mechanism. The control rod is driven into the core region of the reactor by gravity and hydraulic pressure forces supplied by the reactor coolant, thus assuring that common mode failures will not interfere with or prohibit scramming the reactor when necessary.

  1. Nuclear reactor fuel rod attachment system

    DOEpatents

    Not Available

    1980-09-17

    A reusable system is described for removably attaching a nuclear reactor fuel rod to a support member. A locking cap is secured to the fuel rod and a locking strip is fastened to the support member. The locking cap has two opposing fingers shaped to form a socket having a body portion. The locking strip has an extension shaped to rigidly attach to the socket's body portion. The locking cap's fingers are resiliently deflectable. For attachment, the locking cap is longitudinally pushed onto the locking strip causing the extension to temporarily deflect open the fingers to engage the socket's body portion. For removal, the process is reversed.

  2. Improving fuel-rod performance. [PWR; BWR

    SciTech Connect

    Ocken, H.; Knott, S.

    1981-03-01

    To reduce the risk of fuel-rod failures, utilities operate their nuclear reactors within conservative limits on power increases proposed by nuclear-fuel vendors. Of particular concern to US utilities is that adopting these limits results in an industrywide average plant capacity loss of 3% in BWR designs and 0.3% in PWR designs. To replace lost BWR capacity by other generating means currently costs the utilities $150 million annually, and losses for PWRs are about $20 million. Efforts are therefore being made to identify the factors responsible for Zircaloy degradation under PCI condition and to improve nuclear-fuel-rod design and reactor operation.

  3. Optical contact approach to laser rod support.

    NASA Technical Reports Server (NTRS)

    Gurski, T. R.

    1972-01-01

    The successful application of an optical contact is described between a ruby laser rod that has no mechanical support and a sapphire rod. The contact is found to be durable in the environmental conditions associated with a high-power pulsed ruby laser. The described contact technique makes it possible to construct a laser oscillator using an ellipsoidal pump mirror that does not employ dielectric coatings in the cavity. Another advantage consists in that the ruby laser is not shaded from the pump light by mounting jigs at its ends.

  4. Chemical Dosimeter Tube With Coaxial Sensing Rod

    NASA Technical Reports Server (NTRS)

    Lueck, Dale E.

    1993-01-01

    Improved length-of-stain (LOS) chemical dosimeter indicates total dose of chemical vapor in air. Made with rods and tubes of various diameters to obtain various sensitivities and dynamic ranges. Sensitivity larger and dose range smaller when more room for diffusion in gap between tube and rod. Offers greater resistance to changing of color of exposed dye back to color of unexposed condition, greater sensitivity, and higher degree of repeatability. Developed to measure doses of gaseous HCI, dosimeter modified by use of other dyes to indicate doses of other chemical vapors.

  5. HIGH STRENGTH CONTROL RODS FOR NEUTRONIC REACTORS

    DOEpatents

    Lustman, B.; Losco, E.F.; Cohen, I.

    1961-07-11

    Nuclear reactor control rods comprised of highly compressed and sintered finely divided metal alloy panticles and fine metal oxide panticles substantially uniformly distributed theretbrough are described. The metal alloy consists essentially of silver, indium, cadmium, tin, and aluminum, the amount of each being present in centain percentages by weight. The oxide particles are metal oxides of the metal alloy composition, the amount of oxygen being present in certain percentages by weight and all the oxygen present being substantially in the form of metal oxide. This control rod is characterized by its high strength and resistance to creep at elevated temperatures.

  6. Rod Photoreceptor Temporal Properties in Retinitis Pigmentosa

    PubMed Central

    Wen, Yuquan; Locke, Kirsten G.; Hood, Donald C.; Birch, David G.

    2011-01-01

    One of the characteristic signs of retinitis pigmentosa (RP) is the progressive loss of night vision. We have previously shown that the gain of rod photoreceptor activation is moderately reduced in some patients with RP, but this decrease in activation kinetics is not sufficient to account for the night blindness. Recently, single rod recording from animal models of RP showed rods under degeneration remain saturated for shorter periods than normal rods; i.e. are less able to sustain the rod photoresponse. Using paired-flash ERG, here we determine whether rod phototransduction inactivation parameters might also be abnormal in patients with RP. Inactivation parameters were derived from 13 subjects with normal vision, 16 patients with adRP, and 16 patients with autosomal recessive/isolate (rec/iso) RP. The adRP cases included 9 patients with rhodopsin mutations and 7 patients with peripherin/RDS mutations. The inactivation phase was derived using a double-flash paradigm, with a test flash of 2.7 log scot td-sec followed at varying intervals by a 4.2 log scot td-sec probe flash. Derived rod photoresponses to this just-saturating test flash in normal subjects exhibit a critical time to the initiation of recovery (Tsat) of 525±90 (SD) msec. The values of Tsat were 336±104 (SD) msec in patients with adRP (P<0.001) and 271±45 (SD) msec (P<0.001) in patients with rec/iso RP. When Tsat values were categorized by mutations, the values were 294±91 (SD) msec (P<0.001) for rhodopsin mutations, and 389±100 (SD) msec (p=0.01) for peripherin/RDS mutations. Overall, Tsat in patients with RP was significantly correlated with the amplitude of ISCEV standard rod response (r = 0.56; P < 0.001) and the gain of the activation phase of phototransduction (r=0.6, P<0.001). Tsat may be a useful marker for therapeutic efficacy in future clinical trials in RP. PMID:21219898

  7. Intraoperative pulmonary embolism of Harrington rod during spinal surgery: the potential dangers of rod cutting.

    PubMed

    Aylott, Caspar E W; Hassan, Kamran; McNally, Donal; Webb, John K

    2006-12-01

    This is a case report and laboratory-based biomechanics study. The objective is to report the first case of Titanium rod embolisation during scoliosis surgery into the Pulmonary artery. To investigate the potential of an unconstrained cut Titanium rod fragment to cause wounding with reference to recognised weapons. Embolisation of a foreign body to the heart is rare. Bullet embolisation to the heart and lungs is infrequently reported in the last 80 years. Iatrogenic cases of foreign body embolisation are very rare. Fifty 1-2 cm segments of Titanium rod were cut in an unconstrained manner and a novel method was used to calculate velocity. A high-speed camera (6,000 frames/s) was used to further measure velocity and study projectile motion. The wounding potential was investigated using lambs liver, high-speed photography and local dissection. Rod velocities were measured in excess of 23 m s(-1). Rods were seen to tumble end-over-end with a maximum speed of 560 revolutions/s. The maximum kinetic energy was 0.61 J which is approximately 2% that of a crossbow. This is sufficient to cause significant liver damage. The degree of surface damage and internal disruption was influenced by the orientation of the rod fragment at impact. An unconstrained cut segment of a Titanium rod has a significant potential to wound. Precautions should be taken to avoid this potentially disastrous but preventable complication.

  8. Method and means of packaging nuclear fuel rods for handling

    DOEpatents

    Adam, Milton F.

    1979-01-01

    Nuclear fuel rods, especially spent nuclear fuel rods that may show physical distortion, are encased within a metallic enclosing structure by forming a tube about the fuel rod. The tube has previously been rolled to form an overlapping tubular structure and then unrolled and coiled about an axis perpendicular to the tube. The fuel rod is inserted into the tube as the rolled tube is removed from a coiled strip and allowed to reassume its tubular shape about the fuel rod. Rollers support the coiled strip in an open position as the coiled strip is uncoiled and allowed to roll about the fuel rod.

  9. Yearly rates of rod and cone functional loss in retinitis pigmentosa and cone-rod dystrophy.

    PubMed

    Birch, D G; Anderson, J L; Fish, G E

    1999-02-01

    To provide the first measures of the relative rates of rod and cone functional loss in patients with retinitis pigmentosa (RP) or cone-rod dystrophy (CRD). Five-year, prospective natural history study. Ninety-six patients (67 with RP and 29 with CRD) retaining measurable rod-mediated visual function and 5 normal subjects were tested at baseline and annually for 4 consecutive years. Tests of visual function included visual acuity, dark-adaptation thresholds, dark-adapted static perimetry, and rod and cone computer-averaged electroretinograms (ERGs), which were obtained over a range of retinal illuminances. Intervisit variability for each measure was obtained in a subset of patients who were tested twice within a 2-month interval and was used to determine whether an individual patient had shown progression, regression, or no change over a particular study interval. Over a 4-year interval, a significant number of patients with RP (60%) and CRD (62%) showed a decline in cone ERG amplitude. For rod ERG amplitude, the percentage of patients with RP or CRD showing progression was 64% and 45%, respectively. Although visual acuity, dark-adapted threshold, and rod visual field area also declined significantly over the 4-year period, the mean rate of change and the numbers of patients showing progression on these measures were lower than those for ERG measures. On specialized ERG testing, the yearly change in rod ERG threshold in RP was greater than the yearly change in cone ERG threshold, and the rate of progression varied significantly among inheritance types. For patients with CRD, the yearly change in rod threshold was comparable to the yearly change in cone ERG threshold. This study helps to define the natural progression of rod-mediated and cone-mediated functional loss in patients with RP and CRD.

  10. Modeling and simulation performance of sucker rod beam pump

    SciTech Connect

    Aditsania, Annisa; Rahmawati, Silvy Dewi Sukarno, Pudjo; Soewono, Edy

    2015-09-30

    Artificial lift is a mechanism to lift hydrocarbon, generally petroleum, from a well to surface. This is used in the case that the natural pressure from the reservoir has significantly decreased. Sucker rod beam pumping is a method of artificial lift. Sucker rod beam pump is modeled in this research as a function of geometry of the surface part, the size of sucker rod string, and fluid properties. Besides its length, sucker rod string also classified into tapered and un-tapered. At the beginning of this research, for easy modeling, the sucker rod string was assumed as un-tapered. The assumption proved non-realistic to use. Therefore, the tapered sucker rod string modeling needs building. The numerical solution of this sucker rod beam pump model is computed using finite difference method. The numerical result shows that the peak of polished rod load for sucker rod beam pump unit C-456-D-256-120, for non-tapered sucker rod string is 38504.2 lb, while for tapered rod string is 25723.3 lb. For that reason, to avoid the sucker rod string breaks due to the overload, the use of tapered sucker rod beam string is suggested in this research.

  11. Modeling and simulation performance of sucker rod beam pump

    NASA Astrophysics Data System (ADS)

    Aditsania, Annisa; Rahmawati, Silvy Dewi; Sukarno, Pudjo; Soewono, Edy

    2015-09-01

    Artificial lift is a mechanism to lift hydrocarbon, generally petroleum, from a well to surface. This is used in the case that the natural pressure from the reservoir has significantly decreased. Sucker rod beam pumping is a method of artificial lift. Sucker rod beam pump is modeled in this research as a function of geometry of the surface part, the size of sucker rod string, and fluid properties. Besides its length, sucker rod string also classified into tapered and un-tapered. At the beginning of this research, for easy modeling, the sucker rod string was assumed as un-tapered. The assumption proved non-realistic to use. Therefore, the tapered sucker rod string modeling needs building. The numerical solution of this sucker rod beam pump model is computed using finite difference method. The numerical result shows that the peak of polished rod load for sucker rod beam pump unit C-456-D-256-120, for non-tapered sucker rod string is 38504.2 lb, while for tapered rod string is 25723.3 lb. For that reason, to avoid the sucker rod string breaks due to the overload, the use of tapered sucker rod beam string is suggested in this research.

  12. Drop Ejection From an Oscillating Rod

    NASA Technical Reports Server (NTRS)

    Wilkes, E. D.; Basaran, O. A.

    1999-01-01

    The dynamics of a drop of a Newtonian liquid that is pendant from or sessile on a solid rod that is forced to undergo time-periodic oscillations along its axis is studied theoretically. The free boundary problem governing the time evolution of the shape of the drop and the flow field inside it is solved by a method of lines using a finite element algorithm incorporating an adaptive mesh. When the forcing amplitude is small, the drop approaches a limit cycle at large times and undergoes steady oscillations thereafter. However, drop breakup is the consequence if the forcing amplitude exceeds a critical value. Over a wide range of amplitudes above this critical value, drop ejection from the rod occurs during the second oscillation period from the commencement of rod motion. Remarkably, the shape of the interface at breakup and the volume of the primary drop formed are insensitive to changes in forcing amplitude. The interface shape at times close to and at breakup is a multi-valued function of distance measured along the rod axis and hence cannot be described by recently popularized one-dimensional approximations. The computations show that drop ejection occurs without the formation of a long neck. Therefore, this method of drop formation holds promise of preventing formation of undesirable satellite droplets.

  13. Adjustable solitary waves in electroactive rods

    NASA Astrophysics Data System (ADS)

    Wang, Y. Z.; Zhang, C. L.; Dai, H.-H.; Chen, W. Q.

    2015-10-01

    This paper presents an asymptotic analysis of solitary waves propagating in an incompressible isotropic electroactive circular rod subjected to a biasing longitudinal electric displacement. Several asymptotic expansions are introduced to simplify the rod governing equations. The boundary conditions on the lateral surface of the rod are satisfied from the asymptotic point of view. In the limit of finite-small amplitude and long wavelength, a set of ten simplified one-dimensional nonlinear governing equations is established. To validate our approach and the derivation, we compare the linear dispersion relation with the one directly derived from the three-dimensional linear theory in the limit of long wavelength. Then, by the reductive perturbation method, we deduce the far-field equation (i.e. the KdV equation). Finally, the leading order of the electroelastic solitary wave solution is presented. Numerical examples are provided to show the influences of the biasing electric displacement and material constants on the solitary waves. It is found that the biasing electric displacement can modulate the velocity of solitary waves with a prescribed amplitude in the electroactive rod, a very interesting result which may promote the particular application of solitary waves in solids with multi-field coupling.

  14. Genetics Home Reference: intranuclear rod myopathy

    MedlinePlus

    ... fibers and are important for muscle contraction. Attachment (binding) and release of the overlapping thick and thin filaments allows them to move relative to each other so that the muscles can contract. ACTA1 gene mutations that cause intranuclear rod myopathy ...

  15. CONTROL ROD ALLOY CONTAINING NOBLE METAL ADDITIONS

    DOEpatents

    Anderson, W.K.; Ray, W.E.

    1960-05-01

    Silver-base alloys suitable for use in the fabrication of control rods for neutronic reactors are given. The alloy consists of from 0.5 wt.% to about 1.5 wt.% of a noble metal of platinum, ruthenium, rhodium, osmium, or palladium, up to 10 wt.% of cadmium, from 2 to 20 wt.% indium, the balance being silver.

  16. Confinement stabilises single crystal vaterite rods.

    PubMed

    Schenk, Anna S; Albarracin, Eduardo J; Kim, Yi-Yeoun; Ihli, Johannes; Meldrum, Fiona C

    2014-05-11

    Single-crystals of vaterite, the least-stable anhydrous polymorph of CaCO3, are rare in biogenic and synthetic systems. We here describe the synthesis of high aspect ratio single crystal vaterite rods under additive-free conditions by precipitating CaCO3 within the cylindrical pores of track-etch membranes.

  17. A Cambrian origin for vertebrate rods

    PubMed Central

    Asteriti, Sabrina; Grillner, Sten; Cangiano, Lorenzo

    2015-01-01

    Vertebrates acquired dim-light vision when an ancestral cone evolved into the rod photoreceptor at an unknown stage preceding the last common ancestor of extant jawed vertebrates (∼420 million years ago Ma). The jawless lampreys provide a unique opportunity to constrain the timing of this advance, as their line diverged ∼505 Ma and later displayed high-morphological stability. We recorded with patch electrodes the inner segment photovoltages and with suction electrodes the outer segment photocurrents of Lampetra fluviatilis retinal photoreceptors. Several key functional features of jawed vertebrate rods are present in their phylogenetically homologous photoreceptors in lamprey: crucially, the efficient amplification of the effect of single photons, measured by multiple parameters, and the flow of rod signals into cones. These results make convergent evolution in the jawless and jawed vertebrate lines unlikely and indicate an early origin of rods, implying strong selective pressure toward dim-light vision in Cambrian ecosystems. DOI: http://dx.doi.org/10.7554/eLife.07166.001 PMID:26095697

  18. Using the Rods for Structural Grammar.

    ERIC Educational Resources Information Center

    Chambers, Patrick

    The innovative use of a visual cueing device, or rods, in a second language class to represent the parts of speech and the grammatical structure of a sentence is explained and illustrated. The advantages found in it are that individual structures are not learned as isolated elements but rather as parts of a larger system, and that there is more…

  19. Image analysis for measuring rod network properties

    NASA Astrophysics Data System (ADS)

    Kim, Dongjae; Choi, Jungkyu; Nam, Jaewook

    2015-12-01

    In recent years, metallic nanowires have been attracting significant attention as next-generation flexible transparent conductive films. The performance of films depends on the network structure created by nanowires. Gaining an understanding of their structure, such as connectivity, coverage, and alignment of nanowires, requires the knowledge of individual nanowires inside the microscopic images taken from the film. Although nanowires are flexible up to a certain extent, they are usually depicted as rigid rods in many analysis and computational studies. Herein, we propose a simple and straightforward algorithm based on the filtering in the frequency domain for detecting the rod-shape objects inside binary images. The proposed algorithm uses a specially designed filter in the frequency domain to detect image segments, namely, the connected components aligned in a certain direction. Those components are post-processed to be combined under a given merging rule in a single rod object. In this study, the microscopic properties of the rod networks relevant to the analysis of nanowire networks were measured for investigating the opto-electric performance of transparent conductive films and their alignment distribution, length distribution, and area fraction. To verify and find the optimum parameters for the proposed algorithm, numerical experiments were performed on synthetic images with predefined properties. By selecting proper parameters, the algorithm was used to investigate silver nanowire transparent conductive films fabricated by the dip coating method.

  20. Monodisperse hard rods in external potentials.

    PubMed

    Bakhti, Benaoumeur; Karbach, Michael; Maass, Philipp; Müller, Gerhard

    2015-10-01

    We consider linear arrays of cells of volume V(c) populated by monodisperse rods of size σV(c),σ=1,2,..., subject to hardcore exclusion interaction. Each rod experiences a position-dependent external potential. In one application we also examine effects of contact forces between rods. We employ two distinct methods of exact analysis with complementary strengths and different limits of spatial resolution to calculate profiles of pressure and density on mesoscopic and microscopic length scales at thermal equilibrium. One method uses density functionals and the other statistically interacting vacancy particles. The applications worked out include gravity, power-law traps, and hard walls. We identify oscillations in the profiles on a microscopic length scale and show how they are systematically averaged out on a well-defined mesoscopic length scale to establish full consistency between the two approaches. The continuum limit, realized as V(c)→0,σ→∞ at nonzero and finite σV(c), connects our highest-resolution results with known exact results for monodisperse rods in a continuum. We also compare the pressure profiles obtained from density functionals with the average microscopic pressure profiles derived from the pair distribution function.

  1. Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa

    PubMed Central

    Nakamura, Paul A.; Tang, Shibing; Shimchuk, Andy A.; Ding, Sheng; Reh, Thomas A.

    2016-01-01

    Purpose Mutations in rod photoreceptor genes can cause retinitis pigmentosa (RP). Rod gene expression is regulated by the nuclear hormone receptor, Nr2e3. Genetic deletion of Nr2e3 reprograms rods into cells that resemble cone photoreceptors, and might therefore prevent their death from some forms of RP. There are no identified ligands for Nr2e3; however, reverse agonists might mimic the genetic rescue effect and may be therapeutically useful for the treatment of RP. Methods We screened for small molecule modulators of Nr2e3 using primary retinal cell cultures and characterized the most potent, which we have named photoregulin1 (PR1), in vitro and in vivo. We also tested the ability of PR1 to slow the progression of photoreceptor degeneration in two common mouse models of autosomal dominant RP, the RhoP23H and the Pde6brd1 mutations. Results In developing retina, PR1 causes a decrease in rod gene expression and an increase in S opsin+ cones. Photoregulin1 continues to inhibit rod gene expression in adult mice. When applied to two mouse models of RP, PR1 slows the degeneration of photoreceptors. Conclusions Chemical compounds identified as modulators of Nr2e3 activity may be useful for the treatment of RP through their effects on expression of disease-causing mutant genes. PMID:27893103

  2. Looking Northwest Along South End of Rod Loading Building Including ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking Northwest Along South End of Rod Loading Building Including Mezzanine and Gad Loading Area - Hematite Fuel Fabrication Facility, Rod Loading Building, 3300 State Road P, Festus, Jefferson County, MO

  3. VIEW EAST, EAST ELEVATION OF ECCENTRIC HOUSE, NOTE ROD LINES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW EAST, EAST ELEVATION OF ECCENTRIC HOUSE, NOTE ROD LINES EXITING THE BUILDING AND ROD LINES WITH SUPPORTS IN FOREGROUND LEFT. - South Penn Oil Company, G. M. Mead Lot 492 Lease, Morrison Run Field, Clarendon, Warren County, PA

  4. Stimulus-evoked outer segment changes in rod photoreceptors

    NASA Astrophysics Data System (ADS)

    Zhao, Xiaohui; Thapa, Damber; Wang, Benquan; Lu, Yiming; Gai, Shaoyan; Yao, Xincheng

    2016-06-01

    Rod-dominated transient retinal phototropism (TRP) has been recently observed in freshly isolated mouse and frog retinas. Comparative confocal microscopy and optical coherence tomography revealed that the TRP was predominantly elicited from the rod outer segment (OS). However, the biophysical mechanism of rod OS dynamics is still unknown. Mouse and frog retinal slices, which displayed a cross-section of retinal photoreceptors and other functional layers, were used to test the effect of light stimulation on rod OSs. Time-lapse microscopy revealed stimulus-evoked conformational changes of rod OSs. In the center of the stimulated region, the length of the rod OS shrunk, while in the peripheral region, the rod OS swung toward the center region. Our experimental observation and theoretical analysis suggest that the TRP may reflect unbalanced rod disc-shape changes due to localized visible light stimulation.

  5. Reprogramming of adult rod photoreceptors prevents retinal degeneration

    PubMed Central

    Montana, Cynthia L.; Kolesnikov, Alexander V.; Shen, Susan Q.; Myers, Connie A.; Kefalov, Vladimir J.; Corbo, Joseph C.

    2013-01-01

    A prime goal of regenerative medicine is to direct cell fates in a therapeutically useful manner. Retinitis pigmentosa is one of the most common degenerative diseases of the eye and is associated with early rod photoreceptor death followed by secondary cone degeneration. We hypothesized that converting adult rods into cones, via knockdown of the rod photoreceptor determinant Nrl, could make the cells resistant to the effects of mutations in rod-specific genes, thereby preventing secondary cone loss. To test this idea, we engineered a tamoxifen-inducible allele of Nrl to acutely inactivate the gene in adult rods. This manipulation resulted in reprogramming of rods into cells with a variety of cone-like molecular, histologic, and functional properties. Moreover, reprogramming of adult rods achieved cellular and functional rescue of retinal degeneration in a mouse model of retinitis pigmentosa. These findings suggest that elimination of Nrl in adult rods may represent a unique therapy for retinal degeneration. PMID:23319618

  6. 5. DETAIL OF ROD MILL BASE AND CONVEYOR BELT SUPPORT, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. DETAIL OF ROD MILL BASE AND CONVEYOR BELT SUPPORT, EAST VIEW. - Vanadium Corporation of America (VCA) Naturita Mill, Grinding Rod Mill, 3 miles Northwest of Naturita, between Highway 141 & San Miguel River, Naturita, Montrose County, CO

  7. 11. Detail showing stay rods and westerly Samson post; view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Detail showing stay rods and westerly Samson post; view to west. Note slackness of stay rods while draw-span is closed. - Summer Street Bridge, Spanning Reserved Channel, Boston, Suffolk County, MA

  8. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice

    PubMed Central

    Sundermeier, Thomas R.; Zhang, Ning; Vinberg, Frans; Mustafi, Debarshi; Kohno, Hideo; Golczak, Marcin; Bai, Xiaodong; Maeda, Akiko; Kefalov, Vladimir J.; Palczewski, Krzysztof

    2014-01-01

    Photoreceptor cell death is the proximal cause of blindness in many retinal degenerative disorders; hence, understanding the gene regulatory networks that promote photoreceptor survival is at the forefront of efforts to combat blindness. Down-regulation of the microRNA (miRNA)-processing enzyme DICER1 in the retinal pigmented epithelium has been implicated in geographic atrophy, an advanced form of age-related macular degeneration (AMD). However, little is known about the function of DICER1 in mature rod photoreceptor cells, another retinal cell type that is severely affected in AMD. Using a conditional-knockout (cKO) mouse model, we report that loss of DICER1 in mature postmitotic rods leads to robust retinal degeneration accompanied by loss of visual function. At 14 wk of age, cKO mice exhibit a 90% reduction in photoreceptor nuclei and a 97% reduction in visual chromophore compared with those in control littermates. Before degeneration, cKO mice do not exhibit significant defects in either phototransduction or the visual cycle, suggesting that miRNAs play a primary role in rod photoreceptor survival. Using comparative small RNA sequencing analysis, we identified rod photoreceptor miRNAs of the miR-22, miR-26, miR-30, miR-92, miR-124, and let-7 families as potential factors involved in regulating the survival of rods.—Sundermeier, T. R., Zhang, N., Vinberg, F., Mustafi, D., Kohno, H., Golczak, M., Bai, X., Maeda, A., Kefalov, V. J., Palczewski, K. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. PMID:24812086

  9. Composite models for combined rod and fluid dynamics in sucker-rod pumping well systems

    SciTech Connect

    Lekia, S.D.L.

    1989-01-01

    This study presents the derivation and the numerical solution of composite models in which both the rod string and the fluid dynamics are coupled so as to accurately account for the effects of viscous friction in sucker-rod pumped wells. A viscous damped hyperbolic first order partial differential equation is coupled to the time derivative of Hooke's law to model the rod string motion and Navier Stokes equations are used to model the fluid dynamics in the rod-tubing annulus. A set of four equations comprise the composite model from which four sub-models for different flow scenarios are considered. The equations are solved numerically by a shock capturing algorithm known as the MacCormack Explicit Scheme which is a two-step predictor-corrector scheme and is second order accuracy in time and space. Five example problems covering various pump setting depths, fluid properties and surface pumping unit kinematics are presented to study the effects of certain important variables. From the analyses of the results of these example problems it is concluded that (1) while the effects of fluid dynamics may appear masked in shallow to medium depth sucker-rod pumped wells, they can not be ignored in deeper wells where large discrepancies occur in the prediction of system parameters, (2) the load range decreases moderately as viscosity increases and the predicted polished rod horsepower does not change significantly over the range of viscosities studied in shallow to medium depth sucker-rod pumped wells, (3) the presence of small quantities of the gas phase in the fluid column reduces system peak torque and precipitate the need for smaller counterbalance weights and (4) the influence of two-phase gas-liquid flow in the rod-tubing annulus on system design parameters declines with increasing pump setting depth. The results are compared against other design models appearing in the literature.

  10. 13. SOUTHEAST TO SUCKER ROD WORK BENCH AND WOODEN SUCKER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. SOUTHEAST TO SUCKER ROD WORK BENCH AND WOODEN SUCKER ROD STORAGE RACKS ALONG EAST WALL OF FACTORY INTERIOR. AT THIS BENCH WORKERS RIVETED THREADED WROUGHT IRON CONNECTORS TO THE ENDS OF 20' LONG WOODEN SUCKER RODS (THE RODS WHICH EXTEND DOWNWARD IN THE WELL FROM THE GROUND SURFACE TO PISTON DISPLACEMENT PUMPS WHICH ACTUALLY ELEVATE WATER TO THE SURFACE). ROZNOR HEATER AT THE FAR RIGHT WAS ADDED CIRCA 1960. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  11. Light-dependent activation of rod transducin by pineal opsin.

    PubMed

    Max, M; Surya, A; Takahashi, J S; Margolskee, R F; Knox, B E

    1998-10-09

    The pineal gland expresses a unique member of the opsin family (P-opsin; Max, M., McKinnon, P. J., Seidenman, K. J., Barrett, R. K., Applebury, M. L., Takahashi, J. S., and Margolskee, R. F. (1995) Science 267, 1502-1506) that may play a role in circadian entrainment and photo-regulation of melatonin synthesis. To study the function of this protein, an epitope-tagged P-opsin was stably expressed in an embryonic chicken pineal cell line. When incubated with 11-cis-retinal, a light-sensitive pigment was formed with a lambdamax at 462 +/- 2 nm. P-opsin bleached slowly in the dark (t1/2 = 2 h) in the presence of 50 mM hydroxylamine. Purified P-opsin in dodecyl maltoside activated rod transducin in a light-dependent manner, catalyzing the exchange of more than 300 mol of GTPgammaS (guanosine 5'-O-(3-thiotriphosphate))/mol of P-opsin. The initial rate for activation (75 mol of GTPgammaS bound/mol of P-opsin/min at 7 microM) increased with increasing concentrations of transducin. The addition of egg phosphatidylcholine to P-opsin had little effect on the activation kinetics; however, the intrinsic rate of decay in the absence of transducin was accelerated. These results demonstrate that P-opsin is an efficient catalyst for activation of rod transducin and suggest that the pineal gland may contain a rodlike phototransduction cascade.

  12. ROD MILL ROOM, LOOKING EAST, SHOWING DENVER SPIRAL CLASSIFIER, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ROD MILL ROOM, LOOKING EAST, SHOWING DENVER SPIRAL CLASSIFIER, WITH DOMINION ROD MILL IN LEFT BACKGROUND. WATER WAS ADDED TO ORE IN ROD MILL TO MAKE A SLURRY CALLED SLIME. - Shenandoah-Dives Mill, 135 County Road 2, Silverton, San Juan County, CO

  13. Vibrational spraying of liquid by a thin rod

    NASA Astrophysics Data System (ADS)

    Aleksandrov, V. A.

    2008-02-01

    The phenomenon of liquid spraying by a thin rod bent at a right angle and excited with a piezoelectric transducer at one end is observed when the rod touches the open liquid surface at the bending site. The spraying may be accompanied by the formation of a liquid jet, which is emitted from the free end of the bent rod.

  14. 77 FR 1504 - Stainless Steel Wire Rod From India

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... COMMISSION Stainless Steel Wire Rod From India Determination On the basis of the record \\1\\ developed in the... antidumping duty order on stainless steel wire rod From India would be likely to lead to continuation or... contained in USITC Publication 4300 (January 2012), entitled Stainless Steel Wire Rod From...

  15. The Galveston technique using Luque or Cotrel-Dubousset rods.

    PubMed

    Lonstein, J E

    1994-04-01

    The Galveston technique for pelvic fixation in long fusions to the sacrum in neuromuscular and adult scoliosis is an effective technique to help obtain a solid fusion. With careful technique and accurate rod bending, rod insertion, rod contouring, and wire tightening, excellent fixation is obtained that maximizes the fusion rate.

  16. Rod Has High Tensile Strength And Low Thermal Expansion

    NASA Technical Reports Server (NTRS)

    Smith, D. E.; Everton, R. L.; Howe, E.; O'Malley, M.

    1996-01-01

    Thoriated tungsten extension rod fabricated to replace stainless-steel extension rod attached to linear variable-differential transformer in gap-measuring gauge. Threads formed on end of rod by machining with special fixtures and carefully chosen combination of speeds and feeds.

  17. Measurement of the Speed of Sound in a Metal Rod.

    ERIC Educational Resources Information Center

    Mak, Se-yuen; Ng, Yee-kong; Wu, Kam-wah

    2000-01-01

    Suggests two improved methods to measure the speed of sound in a metal rod. One employs a fast timer to measure the time required for a compression pulse to travel along the rod from end to end, and a second uses a microphone to measure the frequency of the fundamental mode of a freely suspending singing rod. (Author/ASK)

  18. ROD INTERNAL PRESSURE QUANTIFICATION AND DISTRIBUTION ANALYSIS USING FRAPCON

    SciTech Connect

    Ivanov, Kostadin; Jessee, Matthew Anderson

    2016-01-01

    The discharge rod internal pressure (RIP) and cladding hoop stress (CHS) distributions are quantified forWatts BarNuclearUnit 1 (WBN1) fuel rods by modeling core cycle design data, intercycle assembly movements, operation data (including modeling significant trips and downpowers), and as-built fuel enrichments and densities of each fuel rod in FRAPCON-3.5. An alternate model for the amount of helium released from zirconium diboride (ZrB2) integral fuel burnable absorber (IFBA) layers is derived and applied to FRAPCON output data to quantify the RIP and CHS for these fuel rods. SCALE/Polaris is used to quantify fuel rod-specific spectral quantities and the amount of gaseous fission products produced in the fuel for use in FRAPCON inputs. Fuel rods with ZrB2 IFBA layers (i.e., IFBA rods) are determined to have RIP predictions that are elevated when compared to fuel rod without IFBA layers (i.e., standard rods) despite the fact that IFBA rods often have reduced fill pressures and annular fuel blankets. Cumulative distribution functions (CDFs) are prepared from the distribution of RIP predictions for all standard and IFBA rods. The provided CDFs allow for the determination of the portion of WBN1 fuel rods that exceed a specified RIP limit. Lastly, improvements to the computational methodology of FRAPCON are proposed.

  19. Rod Has High Tensile Strength And Low Thermal Expansion

    NASA Technical Reports Server (NTRS)

    Smith, D. E.; Everton, R. L.; Howe, E.; O'Malley, M.

    1996-01-01

    Thoriated tungsten extension rod fabricated to replace stainless-steel extension rod attached to linear variable-differential transformer in gap-measuring gauge. Threads formed on end of rod by machining with special fixtures and carefully chosen combination of speeds and feeds.

  20. Viscosity of concentrated suspensions of sphere/rod mixtures

    SciTech Connect

    Mor, R.; Gottlieb, M.; Graham, A.L.; Mondy, L.A.

    1996-05-01

    This paper discusses the viscosity of concentrated suspensions of sphere/rod mixtures by adopting the Thomas relations for spheres and Milliken`s for randomly oriented rods with aspect ratio of 20. The relative viscosity of a mixed suspension may now be calculated for any combination of rods (of aspect ratio 20) and spheres.

  1. CONTROL ROD DRIVE MECHANISM FOR A NUCLEAR REACTOR

    DOEpatents

    Hawke, B.C.; Liederbach, F.J.; Lones, W.

    1963-05-14

    A lead-screw-type control rod drive featuring an electric motor and a fluid motor arranged to provide a selectably alternative driving means is described. The electric motor serves to drive the control rod slowly during normal operation, while the fluid motor, assisted by an automatic declutching of the electric motor, affords high-speed rod insertion during a scram. (AEC)

  2. 35. INTERIOR VIEW, SAME AS ABOVE WITH THE FEEDER ROD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. INTERIOR VIEW, SAME AS ABOVE WITH THE FEEDER ROD INSERTED INTO THE MACHINE; NOTE THE WOOD FEEDER ROD AND FEEDER ROD REST ON THE BACK OF THE STOOL - LaBelle Iron Works, Thirtieth & Wood Streets, Wheeling, Ohio County, WV

  3. Getting into shape: How do rod-like bacteria control their geometry?

    PubMed

    Amir, Ariel; van Teeffelen, Sven

    2014-09-01

    Rod-like bacteria maintain their cylindrical shapes with remarkable precision during growth. However, they are also capable to adapt their shapes to external forces and constraints, for example by growing into narrow or curved confinements. Despite being one of the simplest morphologies, we are still far from a full understanding of how shape is robustly regulated, and how bacteria obtain their near-perfect cylindrical shapes with excellent precision. However, recent experimental and theoretical findings suggest that cell-wall geometry and mechanical stress play important roles in regulating cell shape in rod-like bacteria. We review our current understanding of the cell wall architecture and the growth dynamics, and discuss possible candidates for regulatory cues of shape regulation in the absence or presence of external constraints. Finally, we suggest further future experimental and theoretical directions which may help to shed light on this fundamental problem.

  4. Transport properties of rigid bent-rod macromolecules and of semiflexible broken rods in the rigid-body treatment. Analysis of the flexibility of myosin rod.

    PubMed Central

    Iniesta, A; Díaz, F G; García de la Torre, J

    1988-01-01

    The translational diffusion coefficients, rotational relaxation times and intrinsic viscosities of rigid bent rods, composed by two rodlike arms joined rigidly at an angle alpha, have been evaluated for varying conformation using the latest advances in hydrodynamic theory. We have considered semiflexible rods in which the joint is an elastic hinge or swivel, with a potential V(alpha) = 1/2Q alpha 2 with constant Q. Accepting the rigid-body treatment, we calculate properties of broken rods by averaging alpha-dependent values for rigid rods. The results are finally used to interpret literature values of the properties of myosin rod. Q is regarded as an adjustable parameter, and the value fitted is such that the average bending angle of myosin rod is approximately 60 degrees. PMID:3207825

  5. Variable flow control for a nuclear reactor control rod

    DOEpatents

    Carleton, Richard D.; Bhattacharyya, Ajay

    1978-01-01

    A variable flow control for a control rod assembly of a nuclear reactor that depends on turbulent friction though an annulus. The annulus is formed by a piston attached to the control rod drive shaft and a housing or sleeve fitted to the enclosure housing the control rod. As the nuclear fuel is burned up and the need exists for increased reactivity, the control rods are withdrawn, which increases the length of the annulus and decreases the rate of coolant flow through the control rod assembly.

  6. Rebirth of a control rod at the Phenix power plant

    SciTech Connect

    De Carvalho, Corinne; Vignau, Bernard; Masson, Marc

    2007-07-01

    This paper outlines the operations involved in cleaning the control rod for the complementary shutdown system in the Phenix Power Plant, the French sodium-cooled fast reactor. The Phenix reactor is controlled by six control rods and a complementary shutdown system. The latter comprises a control rod and a mechanism maintaining the rod in position by means of an electromagnet. The electromagnet is continuously supplied with power and holds the rod control assembly in position by magnetisation on a plane circular surface made from pure iron. The bearing capacity of the mechanism on the rod was initially 80 daN with a rod weight of 26.3 daN. This deteriorated progressively over time. The bearing surface of the rod and the electromagnet became contaminated with a deposit of sodium oxides and metallic particles, thus creating an air gap. This reached a figure of 36 daN in 2005 and was deemed not to be sufficient to prevent the rod from dropping at the wrong time during reactor operation. The Power Plant thus decided to replace the rod mechanism in the reactor in an initial phase, followed by the control rod itself. As the Phenix Power Plant had no spare control rods left, they initiated a 'salvage' plan, over two stages, for the rod removed from the reactor and placed in the fuel storage drum: - Inspection of the bearing surface of the rod by means of a borescope to check whether the rod could be salvaged, - A cleaning operation on the bearing face and checks on the bearing capacity of the rod. The operation is subject to very stringent requirements: the rod must not be taken out of the sodium to ensure that it can be reused in the reactor. The operation must thus take place in the fuel storage drum where there are no facilities for such an operation and where operating conditions are very hostile: high temperatures (the sodium in the fuel storage drum is at a temperature of 150 deg. C, high dose rate (3 mGy/h on the bearing surface) and the bearing surface is submerged

  7. Theory of thin-walled rods

    NASA Technical Reports Server (NTRS)

    Goldenveizer, A L

    1951-01-01

    Starting with the Love equations for bending of extensible shells, "principal stress states" are sought for a thin-walled rod of arbitrary but open cross section. Principal stress states exclude those local states arising from end conditions which damp out with distance from the ends. It is found that for rods of intermediate length, long enough to avoid local bending at a support, and short enough that elementary torsion and bending are not the most significant stress states, four principal states exist. Three of these states are associated with the planar distribution of axial stress and are equivalent to the engineering theory of extension and bending of solid sections. The fourth state resembles that which has been called in the literature "bending stress due to torsional", except that cross sections are permitted to bend and the shear along the center line of the cross section is permitted to differ from zero.

  8. Fluid Dynamics in Sucker Rod Pumps

    SciTech Connect

    Cutler, R.P.; Mansure, A.J.

    1999-01-14

    Sucker rod pumps are installed in approximately 90% of all oil wells in the U.S. Although they have been widely used for decades, there are many issues regarding the fluid dynamics of the pump that have not been fully investigated. A project was conducted at Sandia National Laboratories to develop unimproved understanding of the fluid dynamics inside a sucker rod pump. A mathematical flow model was developed to predict pressures in any pump component or an entire pump under single-phase fluid and pumping conditions. Laboratory flow tests were conducted on instrumented individual pump components and on a complete pump to verify and refine the model. The mathematical model was then converted to a Visual Basic program to allow easy input of fluid, geometry and pump parameters and to generate output plots. Examples of issues affecting pump performance investigated with the model include the effects of viscosity, surface roughness, valve design details, plunger and valve pressure differentials, and pumping rate.

  9. Instabilities of a rotating helical rod

    NASA Astrophysics Data System (ADS)

    Park, Yunyoung; Ko, William; Kim, Yongsam; Lim, Sookkyung

    2016-11-01

    Bacteria such as Escherichia coli and Vibrio alginolyticus have helical flagellar filament. By rotating a motor, which is located at the bottom end of the flagellar filament embedded in the cell body, CCW or CW, they swim forward or backward. We model a left-handed helix by the Kirchhoff rod theory and use regularized Stokes formulation to study an interaction between the surrounding fluid and the flagellar filament. We perform numerical studies focusing on relations between physical parameters and critical angular frequency of the motor, which separates overwhiring from twirling. We are also interested in the buckling instability of the hook, which is very flexible elastic rod. By measuring buckling angle, which is an angle between rotational axis and helical axis, we observe the effects of physical parameters on buckling of the hook.

  10. Tritium analysis of irradiated burnable poison rods

    SciTech Connect

    D'Annucci, F.; Baro, G.; Pardue, E.B.S.; Rommelaere, W.

    1982-10-01

    To investigate the tritium content in the various components and to determine the /sup 10/B burnup, a postirradiation examination was carried out on three burnable poison rods that had been irradiated in the first cycle of the Oconee 2 Reactor. The results of the analysis reveal that the Al/sub 2/O/sub 3/-B/sub 4/C pellets retain the major portion (greater than or equal to99%) of all the tritium generated; only a very small quantity (less than or equal to0.5%) of the tritium produced is absorbed by the cladding and no tritium was detected in the plenum gas. Comparison of the average postirradiation /sup 10/B content with the preirradiation content indicates that almost all of the /sup 10/B has been consumed. The experimental results are in good agreement with the calculated tritium content of an irradiated poison rod.

  11. A survey of laser lightning rod techniques

    NASA Technical Reports Server (NTRS)

    Barnes, Arnold A., Jr.; Berthel, Robert O.

    1991-01-01

    The work done to create a laser lightning rod (LLR) is discussed. Some ongoing research which has the potential for achieving an operational laser lightning rod for use in the protection of missile launch sites, launch vehicles, and other property is discussed. Because of the ease with which a laser beam can be steered into any cloud overhead, an LLR could be used to ascertain if there exists enough charge in the clouds to discharge to the ground as triggered lightning. This leads to the possibility of using LLRs to test clouds prior to launching missiles through the clouds or prior to flying aircraft through the clouds. LLRs could also be used to probe and discharge clouds before or during any hazardous ground operations. Thus, an operational LLR may be able to both detect such sub-critical electrical fields and effectively neutralize them.

  12. Intranuclear rods myopathy with autonomic dysfunction.

    PubMed

    Chou, Po-Ching; Liang, Wen-Chen; Nonaka, Ikuya; Mitsuhashi, Satomi; Nishino, Ichizo; Jong, Yuh-Jyh

    2013-08-01

    Intranuclear rods myopathy (IRM), a variant of nemaline myopathy (NM), is characterized by rod structure in the myonuclei. Patients with IRM present with similar symptoms to those of severe infantile-type NM but have worse outcome. Several extramuscular manifestations have been reported in NM but no dysautonomia. We herein report a 2-year-old girl with IRM and a heterozygous mutation, c.430C>T (p.L144F) in ACTA1. During the infancy, the patient showed severe diaphoresis and facial flushing. Arrhythmia and hypertension with the precipitating factors of feeding, defecation, and urination were observed. Sympathetic antagonist was prescribed and showed some effectiveness. Our report may widen the clinical spectrum of IRM. It also reminds clinicians that autonomic dysfunction may occur in patients with IRM or other actinopathies and appropriate treatment may be necessary.

  13. Development of powder-forged connecting rods

    SciTech Connect

    Imahashi, K.; Tsumuki, C.; Nagare, I.

    1984-01-01

    In comparison with conventional hot forging process, powder forging process has much advantage such as good dimensional accuracy, minimum scattering of weight, etc. In spite of much advantage, the powder forged parts have not been mass-produced except for relatively simple shape parts because of technical and economic problems such as low productivity. Solving these problems, powder forging process was applied to connecting rods which required fatigue strength and minimum scattering of weight, and which were complex in shape. As a result, for the first time in the world, mass-production of powder forged connecting rods was carried out, and its properties are as follows: (1) Sufficient fatigue strength; (2) Minimum scattering of weight; and (3) Good dimensional accuracy.

  14. [Rod of Asclepius. Symbol of medicine].

    PubMed

    Young, Pablo; Finn, Bárbara C; Bruetman, Julio E; Cesaro Gelos, Jorge; Trimarchi, Hernán

    2013-09-01

    Symbolism is one of the most archaic forms of human thoughts. Symbol derives from the Latin word symbolum, and the latter from the Greek symbolon or symballo, which means "I coincide, I make matches". The Medicine symbol represents a whole series of historical and ethical values. Asclepius Rod with one serpent entwined, has traditionally been the symbol of scientific medicine. In a misconception that has lasted 500 years, the Caduceus of Hermes, entwined by two serpents and with two wings, has been considered the symbol of Medicine. However, the Caduceus is the current symbol of Commerce. Asclepius Rod and the Caduceus of Hermes represent two professions, Medicine and Commerce that, in ethical practice, should not be mixed. Physicians should be aware of their real emblem, its historical origin and meaning.

  15. Nuclear reactor fuel rod attachment system

    DOEpatents

    Christiansen, David W.

    1982-01-01

    A reusable system for removably attaching a nuclear reactor fuel rod (12) to a support member (14). A locking cap (22) is secured to the fuel rod (12) and a locking strip (24) is fastened to the support member (14). The locking cap (22) has two opposing fingers (24a and 24b) shaped to form a socket having a body portion (26). The locking strip has an extension (36) shaped to rigidly attach to the socket's body portion (26). The locking cap's fingers are resiliently deflectable. For attachment, the locking cap (22) is longitudinally pushed onto the locking strip (24) causing the extension (36) to temporarily deflect open the fingers (24a and 24b) to engage the socket's body portion (26). For removal, the process is reversed.

  16. Hamiltonian formulations and symmetries in rod mechanics

    SciTech Connect

    Dichmann, D.J.; Li, Yiwei; Maddocks, J.H.

    1996-12-31

    This article provides a survey of contemporary rod mechanics, including both dynamic and static theories. Much of what we discuss is regarded as classic material within the mechanics community, but the objective here is to provide a self-contained account accessible to workers interested in modelling DNA. We also describe a number of recent results and computations involving rod mechanics that have been obtained by our group at the University of Maryland. This work was largely motivated by applications to modelling DNA, but our approach reflects a background of research in continuum mechanics. In particular, we emphasize the role that Hamiltonian formulations and symmetries play in the effective computation of special solutions, conservation laws of dynamics and integrals of statics. 41 refs., 10 figs.

  17. On the Vortex Sound from Rotating Rods

    NASA Technical Reports Server (NTRS)

    Yudin, E. Y.

    1947-01-01

    The motion of different bodies imersed in liquid or gaseous media is accompanied by characteristic sound which is excited by the formation of unstable surfaces of separation behind the body, usually disintegrating into a system of discrete vortices(such as the Karman vortex street due to the flow about an infintely long rod, etc.).In the noise from fans,pumps,and similar machtnery, vortexnQif3eI?Yequently predominates. The purpose of this work is to elucidate certain questions of the dependence ofthis sound upon the aerodynamic parameters and the tip speed of the rotating rods,or blades. Although scme material is given below,insufficientto calculate the first rough approximation to the solution of this question,such as the mechanics of vortex formation,never the less certain conclusions maybe found of practical application for the reduction of noise from rotating blades.

  18. Critical heat flux predictions in rod bundles

    SciTech Connect

    Kao, S.P.; Kazimi, M.S.

    1983-01-01

    The prediction of critical heat flux (CHF) in rod bundles has been studied with both subchannel and bundle-average methods. The correlations of Biasi, Bowring, CISE-4, and Barnett were considered. The General Electric 9-rod bundle CHF data were used in the comparisons. Calculations were performed by the two-fluid subchannel code THERMIT-2. The results indicate that the subchannel method yields more conservative CHF predictions than the bundleaverage method. This is attributed to the two-phase turbulent mixing phenomenon in the bundle, which can be modeled only on a subchannel basis. The results also indicate that the CISE-4 correlation had the smallest error in prediction of transition boiling for both subchannel and bundle-average methods.

  19. Photonic mesophases from cut rod rotators

    SciTech Connect

    Stelson, Angela C.; Liddell Watson, Chekesha M.; Avendano, Carlos

    2016-01-14

    The photonic band properties of random rotator mesophases are calculated using supercell methods applied to cut rods on a hexagonal lattice. Inspired by the thermodynamic mesophase for anisotropic building blocks, we vary the shape factor of cut fraction for the randomly oriented basis. We find large, stable bandgaps with high gap isotropy in the inverted and direct structures as a function of cut fraction, dielectric contrast, and filling fraction. Bandgap sizes up to 34.5% are maximized at high dielectric contrast for rods separated in a matrix. The bandgaps open at dielectric contrasts as low as 2.0 for the transverse magnetic polarization and 2.25 for the transverse electric polarization. Additionally, the type of scattering that promotes the bandgap is correlated with the effect of disorder on bandgap size. Slow light properties are investigated in waveguide geometry and slowdown factors up to 5 × 10{sup 4} are found.

  20. Statistical properties of a folded elastic rod

    NASA Astrophysics Data System (ADS)

    Bayart, Elsa; Deboeuf, Stéphanie; Boué, Laurent; Corson, Francis; Boudaoud, Arezki; Adda-Bedia, Mokhtar

    2010-03-01

    A large variety of elastic structures naturally seem to be confined into environments too small to accommodate them; the geometry of folded structures span a wide range of length-scales. The elastic properties of these confined systems are further constrained by self-avoidance as well as by the dimensionality of both structures and container. To mimic crumpled paper, we devised an experimental setup to study the packing of a dimensional elastic object in 2D geometries: an elastic rod is folded at the center of a circular Hele-Shaw cell by a centripetal force. The initial configuration of the rod and the acceleration of the rotating disk allow to span different final folded configurations while the final rotation speed controls the packing intensity. Using image analysis we measure geometrical and mechanical properties of the folded configurations, focusing on length, curvature and energy distributions.

  1. Analytical Solution to the Pneumatic Transient Rod System at ACRR

    SciTech Connect

    Fehr, Brandon Michael

    2016-01-08

    The ACRR pulse is pneumatically driven by nitrogen in a system of pipes, valves and hoses up to the connection of the pneumatic system and mechanical linkages of the transient rod (TR). The main components of the TR pneumatic system are the regulator, accumulator, solenoid valve and piston-cylinder assembly. The purpose of this analysis is to analyze the flow of nitrogen through the TR pneumatic system in order to develop a motion profile of the piston during the pulse and be able to predict the pressure distributions inside both the cylinder and accumulators. The predicted pressure distributions will be validated against pressure transducer data, while the motion profile will be compared to proximity switch data. By predicting the motion of the piston, pulse timing will be determined and provided to the engineers/operators for verification. The motion profile will provide an acceleration distribution to be used in Razorback to more accurately predict reactivity insertion into the system.

  2. Rod Driven Frequency Entrainment and Resonance Phenomena.

    PubMed

    Salchow, Christina; Strohmeier, Daniel; Klee, Sascha; Jannek, Dunja; Schiecke, Karin; Witte, Herbert; Nehorai, Arye; Haueisen, Jens

    2016-01-01

    A controversy exists on photic driving in the human visual cortex evoked by intermittent photic stimulation. Frequency entrainment and resonance phenomena are reported for frequencies higher than 12 Hz in some studies while missing in others. We hypothesized that this might be due to different experimental conditions, since both high and low intensity light stimulation were used. However, most studies do not report radiometric measurements, which makes it impossible to categorize the stimulation according to photopic, mesopic, and scotopic vision. Low intensity light stimulation might lead to scotopic vision, where rod perception dominates. In this study, we investigated photic driving for rod-dominated visual input under scotopic conditions. Twelve healthy volunteers were stimulated with low intensity light flashes at 20 stimulation frequencies, leading to rod activation only. The frequencies were multiples of the individual alpha frequency (α) of each volunteer in the range from 0.40 to 2.30(∗)α. Three hundred and six-channel whole head magnetoencephalography recordings were analyzed in time, frequency, and spatiotemporal domains with the Topographic Matching Pursuit algorithm. We found resonance phenomena and frequency entrainment for stimulations at or close to the individual alpha frequency (0.90-1.10(∗)α) and half of the alpha frequency (0.40-0.55(∗)α). No signs of resonance and frequency entrainment phenomena were revealed around 2.00(∗)α. Instead, on-responses at the beginning and off-responses at the end of each stimulation train were observed for the first time in a photic driving experiment at frequencies of 1.30-2.30(∗)α, indicating that the flicker fusion threshold was reached. All results, the resonance and entrainment as well as the fusion effects, provide evidence for rod-dominated photic driving in the visual cortex.

  3. Rod Driven Frequency Entrainment and Resonance Phenomena

    PubMed Central

    Salchow, Christina; Strohmeier, Daniel; Klee, Sascha; Jannek, Dunja; Schiecke, Karin; Witte, Herbert; Nehorai, Arye; Haueisen, Jens

    2016-01-01

    A controversy exists on photic driving in the human visual cortex evoked by intermittent photic stimulation. Frequency entrainment and resonance phenomena are reported for frequencies higher than 12 Hz in some studies while missing in others. We hypothesized that this might be due to different experimental conditions, since both high and low intensity light stimulation were used. However, most studies do not report radiometric measurements, which makes it impossible to categorize the stimulation according to photopic, mesopic, and scotopic vision. Low intensity light stimulation might lead to scotopic vision, where rod perception dominates. In this study, we investigated photic driving for rod-dominated visual input under scotopic conditions. Twelve healthy volunteers were stimulated with low intensity light flashes at 20 stimulation frequencies, leading to rod activation only. The frequencies were multiples of the individual alpha frequency (α) of each volunteer in the range from 0.40 to 2.30∗α. Three hundred and six-channel whole head magnetoencephalography recordings were analyzed in time, frequency, and spatiotemporal domains with the Topographic Matching Pursuit algorithm. We found resonance phenomena and frequency entrainment for stimulations at or close to the individual alpha frequency (0.90–1.10∗α) and half of the alpha frequency (0.40–0.55∗α). No signs of resonance and frequency entrainment phenomena were revealed around 2.00∗α. Instead, on-responses at the beginning and off-responses at the end of each stimulation train were observed for the first time in a photic driving experiment at frequencies of 1.30–2.30∗α, indicating that the flicker fusion threshold was reached. All results, the resonance and entrainment as well as the fusion effects, provide evidence for rod-dominated photic driving in the visual cortex. PMID:27588002

  4. Analysis of Double-encapsulated Fuel Rods

    SciTech Connect

    Hales, Jason Dean; Medvedev, Pavel G; Novascone, Stephen Rhead; Perez, Danielle Marie; Williamson, Richard L

    2014-09-01

    In an LWR fuel rod, the cladding encapsulates the fuel, contains fission products, and transfers heat directly to the water coolant. In some situations, it may be advantageous to separate the cladding from the coolant through use of a secondary cladding or capsule. This may be done to increase confidence that the fuel or fission products will not mix with the coolant, to provide a mechanism for controlling the rod temperature, or to place multiple experimental rodlets within a single housing. With an axisymmetric assumption, it is possible to derive closed-form expressions for the temperature profile in a fuel rod using radially-constant thermal conductivity in the fuel. This is true for both a traditional fuel-cladding rod and a double-encapsulated fuel (fuel, cladding, capsule) configuration. Likewise, it is possible to employ a fuel performance code to analyse both a traditional and a double-encapsulated fuel. In the case of the latter, two sets of gap heat transfer conditions must be imposed. In this work, we review the equations associated with radial heat transfer in a cylindrical system, present analytic and computational results for a postulated power and gas mixture history for IFA-744, and describe the analysis of the AFC-2A, 2B metallic fuel alloy experiments at the Advanced Test Reactor, including the effect of a release of fission products into the cladding-capsule gap. The computational results for these two cases were obtained using BISON, a fuel performance code under development at Idaho National Laboratory.

  5. ELECTROMAGNETIC APPARATUS FOR MOVING A ROD

    DOEpatents

    Young, J.N.

    1957-08-20

    An electromagnetic device for moving an object in a linear path by increments is described. The device is specifically adapted for moving a neutron absorbing control rod into and out of the core of a reactor and consists essentially of an extension member made of magnetic material connected to one end of the control rod and mechanically flexible to grip the walls of a sleeve member when flexed, a magnetic sleeve member coaxial with and slidable between limit stops along the flexible extension, electromagnetic coils substantially centrally located with respect to the flexible extension to flex the extension member into gripping engagement with the sleeve member when ener gized, moving electromagnets at each end of the sleeve to attract the sleeve when energized, and a second gripping electromagnet positioned along the flexible extension at a distance from the previously mentioned electromagnets for gripping the extension member when energized. In use, the second gripping electromagnet is deenergized, the first gripping electromagnet is energized to fix the extension member in the sleeve, and one of the moving electromagnets is energized to attract the sleeve member toward it, thereby moving the control rod.

  6. Incorporation of squalene into rod outer segments

    SciTech Connect

    Keller, R.K.; Fliesler, S.J. )

    1990-08-15

    We have reported previously that squalene is the major radiolabeled nonsaponifiable lipid product derived from ({sup 3}H)acetate in short term incubations of frog retinas. In the present study, we demonstrate that newly synthesized squalene is incorporated into rod outer segments under similar in vitro conditions. We show further that squalene is an endogenous constituent of frog rod outer segment membranes; its concentration is approximately 9.5 nmol/mumol of phospholipid or about 9% of the level of cholesterol. Pulse-chase experiments with radiolabeled precursors revealed no metabolism of outer segment squalene to sterols in up to 20 h of chase. Taken together with our previous absolute rate studies, these results suggest that most, if not all, of the squalene synthesized by the frog retina is transported to rod outer segments. Synthesis of protein is not required for squalene transport since puromycin had no effect on squalene incorporation into outer segments. Conversely, inhibition of isoprenoid synthesis with mevinolin had no effect on the incorporation of opsin into the outer segment. These latter results support the conclusion that the de novo synthesis and subsequent intracellular trafficking of opsin and isoprenoid lipids destined for the outer segment occur via independent mechanisms.

  7. Interfacial phenomena in hard-rod fluids

    NASA Astrophysics Data System (ADS)

    Shundyak, K. Y.

    2004-05-01

    This thesis addresses questions of interfacial ordering in hard-rod fluids at coexistence of the isotropic and nematic phases and in their contact with simple model substrates. It is organized as follows. Chapter II provides some background information about the relation between the statistical mechanical and thermodynamical level of descriptions of bulk hard-rod fluids, as well as introduces the asymptotically exact Onsager model, and some basic facts of interfacial thermodynamics. Chapter III represents studies of the simplest free IN interface in a fluid of monodisperse Onsager hard rods. For the analysis of this system we develop an efficient perturbative method to determine the (biaxial) one-particle distribution function in inhomogeneous systems. Studies of the free planar isotropic-nematic interfaces are continued in Chapter IV, where they are considered in binary mixtures of hard rods. For sufficiently different particle shapes the bulk phase diagrams of these mixtures exhibit a triple point, where an isotropic (I) phase coexists with two nematic phases (N1 and N2) of different composition. For all explored mixtures we find that upon approach of the triple point the IN2 interface shows complete wetting by an intervening N1 film. We compute the surface tension of isotropic-nematic interfaces, and find a remarkable increase with fractionation. These studies are complemented by an analysis of bulk phase behavior and interfacial properties of nonadditive binary mixtures of thin and thick hard rods in Chapter V. The formulation of this model was motivated by recent experiments in the group of Fraden, who explored the phase behavior of a mixture of viruses with different effective diameters. In our model, species of the same types are considered as interacting with the hard-core repulsive potential, whereas the excluded volume for dissimilar rods is taken to be larger (smaller) then for the pure hard rods. Such a nonadditivity enhances (reduces) fractionation at

  8. Rotational Brownian dynamics of semiflexible broken rods.

    PubMed

    Iniesta, A; Carmen López, M; de la Torre, J G

    1991-06-01

    Using the Brownian dynamics simulation technique, we study the rotational dynamics of a semiflexible broken rod. We employ a suitable bead model with stiff springs between beads and strong forces opposing to bending, except at the joint where flexibility is variable. We consider mostly broken rods with equal arms. From the simulated Brownian trajectories we obtain the correlation function for the second order Legendre polynomial of the reorientational angle of the end-to-end vector and of the arm vector. These correlation functions are closely related to fluorescence anisotropy decay and electric birefringence decay, respectively. In the first case, the relaxation time for a completely flexible rod agrees with the Harvey-Wegener theory, and in the second, the longest relaxation time agrees well with that obtained from the rigid-body treatment over the whole range of flexibility. Furthermore, we discuss the relative importance of flexibility in both types of decay. Finally, we present results for a case with unequal arms, confirming the validity of the Harvey-Wegener theory and the rigid-body treatment.

  9. On the metabolism of the rod outer segments.

    PubMed Central

    Carretta, A; Cavaggioni, A

    1976-01-01

    1. The high energy phosphate esters available for the luminescent reaction of the firefly lantern extract correspond, in the dark adapted rods of the frog, to 7 X 10(-16) mole of ATP per rod, corresponding to ca. 1-4 mM. 2. Rods isolated from light adapted eyes contain a smaller amount. 3. The high energy phosphate esters are reduced spontaneously at a rate of 50% in 24 min, in the isolated rods in darkness. 4. Bleaching a few per cent of the rhodopsin molecules of a rod suspension induces a 60% decrease achieved in less than 12 sec. 5. The ionophore A23187 decreases the high energy phosphate esters when the extracellular free Ca concentration is greater than 10(-7) M, suggesting that ATP is consumed in pumping Ca ions out of the rods, or into the disks contained in the rods, or both. PMID:781215

  10. Measurements of lightning rod responses to nearby strikes

    NASA Astrophysics Data System (ADS)

    Moore, C. B.; Aulich, G. D.; Rison, W.

    2000-05-01

    Following Benjamin Franklin's invention of the lightning rod, based on his discovery that electrified objects could be discharged by approaching them with a metal needle in hand, conventional lightning rods in the U.S. have had sharp tips. In recent years, the role of the sharp tip in causing a lightning rod to act as a strike receptor has been questioned leading to experiments in which pairs of various sharp-tipped and blunt rods have been exposed beneath thunderclouds to determine the better strike receptor. After seven years of tests, none of the sharp Franklin rods or of the so-called “early streamer emitters” has been struck, but 12 blunt rods with tip diameters ranging from 12.7 mm to 25.4 mm have taken strikes. Our field experiments and our analyses indicate that the strike-reception probabilities of Franklin's rods are greatly increased when their tips are made moderately blunt.

  11. Rod-cone interactions and analysis of retinal disease.

    PubMed Central

    Arden, G B; Hogg, C R

    1985-01-01

    Cone flicker threshold rises as the rods dark adapt, though the cone threshold to continuous light remains constant. The rise is normally about 1 log unit, but in certain patients who complain of night blindness it may be as great as 2.5 log units. In these persons the kinetics of the rod-cone interaction are those of the recovery of rod sensitivity. The rods impose a low-pass filter on the cones. This effect is absent in congenital nyctalopia and X-linked retinoschisis. We suggest that cone flicker is maintained through a feedback system involving horizontal cells, and when the rod dark current returns in dark adaptation this feedback is altered. Rod cone interaction thus tests rod dark current, and cases of abnormal interaction in patients with retinitis pigmentosa occur, which indicate that the transduction mechanism and the membrane dark current may be differentially affected. Images PMID:3873959

  12. Nuclear thermionic converter. [tungsten-thorium oxide rods

    NASA Technical Reports Server (NTRS)

    Phillips, W. M.; Mondt, J. F. (Inventor)

    1977-01-01

    Efficient nuclear reactor thermionic converter units are described which can be constructed at low cost and assembled in a reactor which requires a minimum of fuel. Each converter unit utilizes an emitter rod with a fluted exterior, several fuel passages located in the bulges that are formed in the rod between the flutes, and a collector receiving passage formed through the center of the rod. An array of rods is closely packed in an interfitting arrangement, with the bulges of the rods received in the recesses formed between the bulges of other rods, thereby closely packing the nuclear fuel. The rods are constructed of a mixture of tungsten and thorium oxide to provide high power output, high efficiency, high strength, and good machinability.

  13. Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9

    PubMed Central

    Peinado Allina, Gabriel; Fortenbach, Christopher; Gross, Owen P.; Pugh, Edward N.

    2017-01-01

    The temporal resolution of scotopic vision is thought to be constrained by the signaling kinetics of retinal rods, which use a highly amplified G-protein cascade to transduce absorbed photons into changes in membrane potential. Much is known about the biochemical mechanisms that determine the kinetics of rod responses ex vivo, but the rate-limiting mechanisms in vivo are unknown. Using paired flash electroretinograms with improved signal-to-noise, we have recorded the amplitude and kinetics of rod responses to a wide range of flash strengths from living mice. Bright rod responses in vivo recovered nearly twice as fast as all previous recordings, although the kinetic consequences of genetic perturbations previously studied ex vivo were qualitatively similar. In vivo, the dominant time constant of recovery from bright flashes was dramatically reduced by overexpression of the RGS9 complex, revealing G-protein deactivation to be rate limiting for recovery. However, unlike previous ex vivo recordings, dim flash responses in vivo were relatively unaffected by RGS9 overexpression, suggesting that other mechanisms, such as calcium feedback dynamics that are strongly regulated by the restricted subretinal microenvironment, act to determine rod dim flash kinetics. To assess the consequences for scotopic vision, we used a nocturnal wheel-running assay to measure the ability of wild-type and RGS9-overexpressing mice to detect dim flickering stimuli and found no improvement when rod recovery was speeded by RGS9 overexpression. These results are important for understanding retinal circuitry, in particular as modeled in the large literature that addresses the relationship between the kinetics and sensitivity of retinal responses and visual perception. PMID:28302678

  14. Between a Map and a Data Rod

    NASA Technical Reports Server (NTRS)

    Teng, William; Rui, Hualan; Strub, Richard; Vollmer, Bruce

    2015-01-01

    A Digital Divide has long stood between how NASA and other satellite-derived data are typically archived (time-step arrays or maps) and how hydrology and other point-time series oriented communities prefer to access those data. In essence, the desired method of data access is orthogonal to the way the data are archived. Our approach to bridging the Divide is part of a larger NASA-supported data rods project to enhance access to and use of NASA and other data by the Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) Hydrologic Information System (HIS) and the larger hydrology community. Our main objective was to determine a way to reorganize data that is optimal for these communities. Two related objectives were to optimally reorganize data in a way that (1) is operational and fits in and leverages the existing Goddard Earth Sciences Data and Information Services Center (GES DISC) operational environment and (2) addresses the scaling up of data sets available as time series from those archived at the GES DISC to potentially include those from other Earth Observing System Data and Information System (EOSDIS) data archives. Through several prototype efforts and lessons learned, we arrived at a non-database solution that satisfied our objectivesconstraints. We describe, in this presentation, how we implemented the operational production of pre-generated data rods and, considering the tradeoffs between length of time series (or number of time steps), resources needed, and performance, how we implemented the operational production of on-the-fly (virtual) data rods. For the virtual data rods, we leveraged a number of existing resources, including the NASA Giovanni Cache and NetCDF Operators (NCO) and used data cubes processed in parallel. Our current benchmark performance for virtual generation of data rods is about a years worth of time series for hourly data (9,000 time steps) in 90 seconds. Our approach is a specific implementation of

  15. Successful gene therapy in the RPGRIP1-deficient dog: a large model of cone-rod dystrophy.

    PubMed

    Lhériteau, Elsa; Petit, Lolita; Weber, Michel; Le Meur, Guylène; Deschamps, Jack-Yves; Libeau, Lyse; Mendes-Madeira, Alexandra; Guihal, Caroline; François, Achille; Guyon, Richard; Provost, Nathalie; Lemoine, Françoise; Papal, Samantha; El-Amraoui, Aziz; Colle, Marie-Anne; Moullier, Philippe; Rolling, Fabienne

    2014-02-01

    For the development of new therapies, proof-of-concept studies in large animal models that share clinical features with their human counterparts represent a pivotal step. For inherited retinal dystrophies primarily involving photoreceptor cells, the efficacy of gene therapy has been demonstrated in canine models of stationary cone dystrophies and progressive rod-cone dystrophies but not in large models of progressive cone-rod dystrophies, another important cause of blindness. To address the last issue, we evaluated gene therapy in the retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1)-deficient dog, a model exhibiting a severe cone-rod dystrophy similar to that seen in humans. Subretinal injection of AAV5 (n = 5) or AAV8 (n = 2) encoding the canine Rpgrip1 improved photoreceptor survival in transduced areas of treated retinas. Cone function was significantly and stably rescued in all treated eyes (18-72% of those recorded in normal eyes) up to 24 months postinjection. Rod function was also preserved (22-29% of baseline function) in four of the five treated dogs up to 24 months postinjection. No detectable rod function remained in untreated contralateral eyes. More importantly, treatment preserved bright- and dim-light vision. Efficacy of gene therapy in this large animal model of cone-rod dystrophy provides great promise for human treatment.

  16. Both NMDA and non-NMDA receptors mediate glutamate stimulation induced cofilin rod formation in cultured hippocampal neurons.

    PubMed

    Chen, Ben; Jiang, Min; Zhou, Mi; Chen, Lulan; Liu, Xu; Wang, Xin; Wang, Yun

    2012-11-27

    Cofilin is the major actin-depolymerizing factor in the CNS for the regulation of actin dynamics. Neurodegenerative stimuli can induce the formation of cofilin rod, a pathological structure composed of cofilin and actin. The formation of cofilin rod was found to disrupt synapse function and cause neurite loss. The aim of the present study is to study the whole process of cofilin rod formation pattern in cultured hippocampal neurons under excitotoxic stimulation and to explore its underlying pharmacological mechanism. By using live cell imaging of neurons overexpressing EGFP-tagged wild type cofilin, we found a two-phase pattern of rod formation induced by glutamate stimulation. The early phase of rod formation occurred shortly after stimulation (∼0.5h) but quickly dissolved within 2h. The second phase happened within a much longer time window, 8h after stimulation. Immunostaining of endogenous cofilin in neurons also confirmed this glutamate stimulation induced two-phase rod formation pattern. The first phase was co-related with intracellular calcium concentration and pH increase while the second phase was not. These two phases of cofilin rod formation induced by glutamate stimulation was antagonized by both non-NMDA and NMDA receptor antagonist DNQX and AP5, respectively. Our results for the first time demonstrate the dynamic cofilin rod formation pattern under stress stimulation in detail by time lapse imaging. These findings reveal a novel time course of excitotoxicity induced neuronal damage and indicate a potential target of neuropathy treatment of neurodegenerative diseases. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods.

    PubMed

    Berry, Justin; Frederiksen, Rikard; Yao, Yun; Nymark, Soile; Chen, Jeannie; Cornwall, Carter

    2016-06-29

    GPCRs regulate a wide variety of physiological processes, including taste, smell, hearing, vision, and cardiovascular, endocrine, and reproductive homeostasis. An important feature of GPCR signaling is its timely termination. This normally occurs when, after their activation, GPCRs are rapidly phosphorylated by specific receptor kinases and subsequently bound by cognate arrestins. Recovery of receptor sensitivity to the ground state then requires dephosphorylation of the receptor and unbinding of arrestin, processes that are poorly understood. Here we investigate in mouse rod photoreceptors the relationship between rhodopsin dephosphorylation and recovery of visual sensitivity. Copyright © 2016 the authors 0270-6474/16/366973-15$15.00/0.

  18. Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods

    PubMed Central

    Berry, Justin; Frederiksen, Rikard; Yao, Yun; Nymark, Soile

    2016-01-01

    topology. Signaling by GPCRs regulate a wide variety of physiological processes, including taste, smell, hearing, vision, and cardiovascular, endocrine, and reproductive homeostasis. An important feature of GPCR signaling is its timely termination. This normally occurs when, after their activation, GPCRs are rapidly phosphorylated by specific receptor kinases and subsequently bound by cognate arrestins. Recovery of receptor sensitivity to the ground state then requires dephosphorylation of the receptor and unbinding of arrestin, processes that are poorly understood. Here we investigate in mouse rod photoreceptors the relationship between rhodopsin dephosphorylation and recovery of visual sensitivity. PMID:27358455

  19. Visual transduction in human rod photoreceptors.

    PubMed

    Kraft, T W; Schneeweis, D M; Schnapf, J L

    1993-05-01

    1. Photocurrents were recorded with suction electrodes from rod photoreceptors of seven humans. 2. Brief flashes of light evoked transient outward currents of up to 20 pA. With increasing light intensity the peak response amplitude increased along an exponential saturation function. A half-saturating peak response was evoked by approximately sixty-five photoisomerizations. 3. Responses to brief dim flashes rose to a peak in about 200 ms. The waveform was roughly like the impulse response of a series of four to five low-pass filters. 4. The rising phases of the responses to flashes of increasing strength were found to fit with a biochemical model of phototransduction with an 'effective delay time' and 'characteristic time' of about 2 and 800 ms, respectively. 5. Spectral sensitivities were obtained over a wavelength range from 380 to 760 nm. The action spectrum, which peaked at 495 nm, followed the template described for photoreceptors in the macaque retina. Variation between rods in the position of the spectrum on the wavelength axis was small. 6. The scotopic luminosity function derived from human psychophysical experiments was found to agree well with the measured rod action spectrum after adjustments were made for lens absorption and photopigment self-screening in the intact eye. 7. Responses to steps of light rose monotonically to a maintained level, showing little or no relaxation. Nevertheless, the relationship between light intensity and steady-state response amplitude was shallower than that expected from simple response saturation. This is consistent with an adaptation mechanism acting on a rapid time scale. 8. Flash sensitivity fell with increasing intensities of background light according to Weber's law. Sensitivity was reduced twofold by lights evoking about 120 photoisomerizations per second. Background lights decreased the time to peak and the integration time of the flash response by up to 20%.

  20. Cofilin nuclear-cytoplasmic shuttling affects cofilin-actin rod formation during stress.

    PubMed

    Munsie, Lise Nicole; Desmond, Carly R; Truant, Ray

    2012-09-01

    Cofilin protein is involved in regulating the actin cytoskeleton during typical steady state conditions, as well as during cell stress conditions where cofilin saturates F-actin, forming cofilin-actin rods. Cofilin can enter the nucleus through an active nuclear localization signal (NLS), accumulating in nuclear actin rods during stress. Here, we characterize the active nuclear export of cofilin through a leptomycin-B-sensitive, CRM1-dependent, nuclear export signal (NES). We also redefine the NLS of cofilin as a bipartite NLS, with an additional basic epitope required for nuclear localization. Using fluorescence lifetime imaging microscopy (FLIM) and Förster resonant energy transfer (FRET) between cofilin moieties and actin, as well as automated image analysis in live cells, we have defined subtle mutations in the cofilin NLS that allow cofilin to bind actin in vivo and affect cofilin dynamics during stress. We further define the requirement of cofilin-actin rod formation in a system of cell stress by temporal live-cell imaging. We propose that cofilin nuclear shuttling is critical for the cofilin-actin rod stress response with cofilin dynamically communicating between the nucleus and cytoplasm during cell stress.

  1. Activation of mislocalized opsin kills rod cells: a novel mechanism for rod cell death in retinal disease.

    PubMed

    Alfinito, Peter D; Townes-Anderson, Ellen

    2002-04-16

    Rod photoreceptors are highly compartmentalized sensory neurons that maintain strict ultrastructural and molecular polarity. Structural subdivisions include the outer segment, inner segment, cell body, and synaptic terminal. The visual pigment rhodopsin is found predominantly in membranes of the rod cell outer segment but becomes mislocalized, appearing throughout the plasma membrane of the cell in many retinal diseases and injuries. Currently, there is no known link between rhodopsin redistribution and rod cell death. We propose that activation of mislocalized rhodopsin kills rod cells by stimulating normally inaccessible signaling pathways. This hypothesis was tested in primary retinal cell cultures, which contain photoreceptors. In rod photoreceptors, opsin immunofluorescence occurred throughout the rod cell plasma membrane. Activation of this mislocalized opsin by photostimulation after formation of isorhodopsin or by incubation with beta-ionone (opsin agonist) killed 19-30% of rod cells. Rod cell death was apoptotic, as indicated by marked chromatin condensation and the requirement for caspase-3 activation. Rod cell death could be induced by forskolin (adenylate cyclase agonist), and conversely, beta-ionone-induced cell death could be blocked by cotreatment with SQ22536 (an adenylate cyclase inhibitor). Pertussis toxin (a G protein inhibitor) also blocked beta-ionone-induced cell death. The data support a mechanism by which activation of mislocalized opsin initiates apoptotic rod cell death through G protein stimulation of adenylate cyclase.

  2. ALLOY COMPOSITION FOR NEUTRONIC REACTOR CONTROL RODS

    DOEpatents

    Lustman, B.; Losco, E.F.; Snyder, H.J.; Eggleston, R.R.

    1963-01-22

    This invention relates to alloy compositons suitable as cortrol rod material consisting of, by weight, from 85% to 85% Ag, from 2% to 20% In, from up to 10% of Cd, from up to 5% Sn, and from up to 1.5% Al, the amount of each element employed being determined by the equation X + 2Y + 3Z + 3W + 4V = 1.4 and less, where X, Y, Z, W, and V represent the atom fractions of the elements Ag, Cd, In, Al and Sn. (AEC)

  3. Locally periodic Timoshenko rod: experiment and theory.

    PubMed

    Díaz-de-Anda, A; Pimentel, A; Flores, J; Morales, A; Gutiérrez, L; Méndez-Sánchez, R A

    2005-05-01

    The flexural vibrations of a locally periodic rod, which consists of N unit cells, are discussed both from the experimental and theoretical points of view. Timoshenko's beam theory and the transfer matrix method are used to calculate the normal-mode frequencies and amplitudes. The theoretical values are then compared with the experimental ones, which are obtained using an electromagnetic acoustic transducer (EMAT). Good agreement between the numerical results and the experimental measurements is obtained. It is shown that as N grows, a band spectrum emerges.

  4. Nonequilibrium clustering of self-propelled rods.

    PubMed

    Peruani, Fernando; Deutsch, Andreas; Bär, Markus

    2006-09-01

    Motivated by aggregation phenomena in gliding bacteria, we study collective motion in a two-dimensional model of active, self-propelled rods interacting through volume exclusion. In simulations with individual particles, we find that particle clustering is facilitated by a sufficiently large packing fraction eta or length-to-width ratio kappa . The transition to clustering in simulations is well captured by a mean-field model for the cluster size distribution, which predicts that the transition values kappac of the aspect ratio for a fixed packing fraction eta are given by kappac=Ceta-1 where C is a constant.

  5. Gas Interference in Sucker Rod Pump

    NASA Astrophysics Data System (ADS)

    Samad, Abdus

    2010-10-01

    Commonly used artificial lift or dewatering system is sucker rod pump and gas interference of the pump is the biggest issue in the oil and gas industry. Gas lock or fluid pound problems occur due to the gas interference when the pump has partially or completely unfilled plunger barrel. There are several techniques available in the form of patents to solve these problems but those techniques have positive as well as negative aspects. Some of the designs rely on the leakage and some of the designs rely on the mechanical arrangements etc to break the gas lock. The present article compares the existing gas interference handling techniques.

  6. Rodded shutdown system for a nuclear reactor

    DOEpatents

    Golden, Martin P.; Govi, Aldo R.

    1978-01-01

    A top mounted nuclear reactor diverse rodded shutdown system utilizing gas fed into a pressure bearing bellows region sealed at the upper extremity to an armature. The armature is attached to a neutron absorber assembly by a series of shafts and connecting means. The armature is held in an uppermost position by an electromagnet assembly or by pressurized gas in a second embodiment. Deenergizing the electromagnet assembly, or venting the pressurized gas, causes the armature to fall by the force of gravity, thereby lowering the attached absorber assembly into the reactor core.

  7. Nonelastomeric Rod Seals for Advanced Hydraulic Systems

    NASA Technical Reports Server (NTRS)

    Hady, W. F.; Waterman, A. W.

    1976-01-01

    Advanced high temperature hydraulic system rod sealing requirements can be met by using seals made of nonelastomeric (plastic) materials in applications where elastomers do not have adequate life. Exploratory seal designs were optimized for advanced applications using machinable polyimide materials. These seals demonstrated equivalent flight hour lives of 12,500 at 350 F and 9,875 at 400 F in advanced hydraulic system simulation. Successful operation was also attained under simulated space shuttle applications; 96 reentry thermal cycles and 1,438 hours of vacuum storage. Tests of less expensive molded plastic seals indicated a need for improved materials to provide equivalent performance to the machined seals.

  8. VISUAL ADAPTATION AND CHEMISTRY OF THE RODS

    PubMed Central

    Wald, George; Clark, Anna-Betty

    1937-01-01

    1. The reality of a chemical cycle proposed to describe the rhodopsin system is tested with dark adaptation measurements. 2. The first few minutes of rod dark adaptation are rapid following short, slower following long irradiation. As dark adaptation proceeds, the slow process grows more prominent, and occupies completely the final stages of adaptation. 3. Light adaptation displays similar duality. As the exposure to light of constant intensity lengthens, the visual threshold rises, and independently the speed of dark adaptation decreases. 4. These results conform with predictions from the chemical equations. PMID:19873041

  9. The Coherence Time of Quantum Rod Qubit

    NASA Astrophysics Data System (ADS)

    Cai, Chunyu; Zhao, Cuilan; Xiao, Jinglin

    2015-04-01

    Quantum systems are usually very fragile and external fields will break the quantum coherence for information storing. Here we study the properties of coherence time (CT) of a quantum rod (QR) qubit by the Pekar type variational (PTV) method. Our numerical results show that the CT will increase with increasing QR's transverse and longitudinal effective confinement lengths (TLECLs), whereas it is a decreasing function of the ellipsoidal aspect ratio (EAR) and polaron radius (PR). Consequently, we can improve the CT by (i) increasing the TLECLs; (ii) decreasing the EAR and PR.

  10. High-yield production of hydrophobins RodA and RodB from Aspergillus fumigatus in Pichia pastoris.

    PubMed

    Pedersen, Mona Højgaard; Borodina, Irina; Moresco, Jacob Lange; Svendsen, Winnie Edith; Frisvad, Jens Christian; Søndergaard, Ib

    2011-06-01

    Hydrophobins are small fungal proteins with amphipatic properties and the ability to self-assemble on a hydrophobic/hydrophilic interface; thus, many technical applications for hydrophobins have been suggested. The pathogenic fungus Aspergillus fumigatus expresses the hydrophobins RodA and RodB on the surface of its conidia. RodA is known to be of importance to the pathogenesis of the fungus, while the biological role of RodB is currently unknown. Here, we report the successful expression of both hydrophobins in Pichia pastoris and present fed-batch fermentation yields of 200-300 mg/l fermentation broth. Protein bands of expected sizes were detected by SDS-PAGE and western blotting, and the identity was further confirmed by tandem mass spectrometry. Both proteins were purified using his-affinity chromatography, and the high level of purity was verified by silver-stained SDS-PAGE. Recombinant RodA as well as rRodB were able to convert a glass surface from hydrophilic to hydrophobic similar to native RodA, but only rRodB was able to decrease the hydrophobicity of a Teflon-like surface to the same extent as native RodA, while rRodA showed this ability to a lesser extent. Recombinant RodA and native RodA showed a similar ability to emulsify air in water, while recombinant RodB could also emulsify oil in water better than the control protein bovine serum albumin (BSA). This is to our knowledge the first successful expression of hydrophobins from A. fumigatus in a eukaryote host, which makes it possible to further characterize both hydrophobins. Furthermore, the expression strategy and fed-batch production using P. pastoris may be transferred to hydrophobins from other species.

  11. Convergent synthesis of multiporphyrin light-harvesting rods

    DOEpatents

    Lindsey, Jonathan S.; Loewe, Robert S.

    2003-08-05

    The present invention provides a convergent method for the synthesis of light harvesting rods. The rods are oligomers of the formula A.sup.1 (A.sup.b+1).sub.b, wherein b is at least 1, A.sup.1 through A.sup.b+1 are covalently coupled rod segments, and each rod segment A.sup.1 through A.sup.1+b comprises a compound of the formula X.sup.1 (X.sup.m+1).sub.m wherein m is at least 1 and X.sup.1 through X.sup.m+1 are covalently coupled porphyrinic macrocycles. Light harvesting arrays and solar cells containing such light harvesting rods are also described, along with intermediates useful in such methods and rods produced by such methods.

  12. Monolayers of hard rods on planar substrates. I. Equilibrium.

    PubMed

    Oettel, M; Klopotek, M; Dixit, M; Empting, E; Schilling, T; Hansen-Goos, H

    2016-08-21

    The equilibrium properties of hard rod monolayers are investigated in a lattice model (where position and orientation of a rod are restricted to discrete values) as well as in an off-lattice model featuring spherocylinders with continuous positional and orientational degrees of freedom. Both models are treated using density functional theory and Monte Carlo simulations. Upon increasing the density of rods in the monolayer, there is a continuous ordering of the rods along the monolayer normal ("standing up" transition). The continuous transition also persists in the case of an external potential which favors flat-lying rods in the monolayer. This behavior is found in both the lattice and the continuum models. For the lattice model, we find very good agreement between the results from the specific DFT used (lattice fundamental measure theory) and simulations. The properties of lattice fundamental measure theory are further illustrated by the phase diagrams of bulk hard rods in two and three dimensions.

  13. Monolayers of hard rods on planar substrates. I. Equilibrium

    NASA Astrophysics Data System (ADS)

    Oettel, M.; Klopotek, M.; Dixit, M.; Empting, E.; Schilling, T.; Hansen-Goos, H.

    2016-08-01

    The equilibrium properties of hard rod monolayers are investigated in a lattice model (where position and orientation of a rod are restricted to discrete values) as well as in an off-lattice model featuring spherocylinders with continuous positional and orientational degrees of freedom. Both models are treated using density functional theory and Monte Carlo simulations. Upon increasing the density of rods in the monolayer, there is a continuous ordering of the rods along the monolayer normal ("standing up" transition). The continuous transition also persists in the case of an external potential which favors flat-lying rods in the monolayer. This behavior is found in both the lattice and the continuum models. For the lattice model, we find very good agreement between the results from the specific DFT used (lattice fundamental measure theory) and simulations. The properties of lattice fundamental measure theory are further illustrated by the phase diagrams of bulk hard rods in two and three dimensions.

  14. Swarming and swirling in self-propelled polar granular rods

    NASA Astrophysics Data System (ADS)

    Kudrolli, Arshad; Lumay, Geoffroy; Volfson, Dmitri; Tsimring, Lev

    2008-03-01

    We discuss the dynamics of ``self-propelled" polar rods experimentally and numerically. In the experiment, the polar motion was achieved by vibrating rods with asymmetric mass distribution. In the numerics, we postulate a driving force acting along the axis of the rod. We observe aggregation of rods at the boundaries because of the inability of rods to turn around and escape for high enough density under low noise conditions. As vibration strength and thus noise is increased, the aggregation reduces and a uniformly distributed state displaying local orientation order and swirls are observed. We observe greater than √n density fluctuations which are in a qualitative agreement with the Toner-Tu model, but this agreement should not be over-emphasized since the model is directly applicable to a nematic regime. Our findings elucidate an important and interesting interplay between the shape and the directed motion in realistic self-propelled rods which affects the phenomenology of their collective dynamics.

  15. Stirring with ghost rods in a lid-driven cavity

    NASA Astrophysics Data System (ADS)

    Kumar, Pankaj; Chen, Jie; Stremler, Mark

    2009-11-01

    It has shown that passive fluid particles moving on periodic orbits can be used to `stir' a viscous fluid in a two-dimensional lid-driven cavity that exhibits a figure-eight flow pattern (Stremler & Chen 2007). Fluid motion in the vicinity of these particles produces ``ghost rod'' structures that behave like semi-permeable rods in the flow. Since these ghost rods are present due to the system dynamics, perturbations in the boundary conditions lead to variations in the existence and structure of the ghost rods. We discuss these variations and assess the role of ghost rods in mixing over a range of operating conditions for this system. The results suggest that ghost rods can play an important role in mixing for other counter-rotating flows.

  16. Dynamic, multiaxial impact response of confined and unconfined ceramic rods

    SciTech Connect

    Wise, J.L.; Grady, D.E.

    1993-09-01

    A new configuration for impact testing was implemented which yielded time-resolved measurements of the dynamic response of materials undergoing multiaxial strain. With this`-Method, one end of an initially stationary rod (ie., right circular cylinder) of test material was subjected to planar impact with a flat-faced projectile. The test rod was either free (unconfined) or mounted within a close-fitting sleeve which provided lateral confinement. Velocity interferometer diagnostics monitored the axial (longitudinal) velocity of the rod free end, and the transverse (radial) velocity for one or more points on the periphery of the rod or confinement sleeve. Analysis of the resultant velocity records allowed assessment of material properties, such as wave speeds and compressive yield strength, without the requirement of intact recovery of the rod. Data were obtained for alumina (Coors AD-99.5) rods in a series of tests involving variations in confinement and peak impact stress.

  17. Safety analysis forseismic motion of control rods accounting for rod misalignment

    SciTech Connect

    Osmin, W.L.; Paik, I.K.

    1992-01-01

    The purpose of this report is to provide a summary of the results of three safety analyses performed by the SRL Safety Analysis Group (SAG) to assess the safety impact of control rod motion induced by a Design Basis Earthquake (DBE).

  18. Do rod signals control stimulus field prevalence in binocular rivalry?

    PubMed

    Young, R S; Young, G A

    1979-02-01

    We tested the hypothesis that rod signals mediate the effect of luminance on field prevalence in binocular rivalry. Results show that (1) field prevalence saturates at a luminance that is less than 0.001 that of the value reported for rod saturation, (2) the spectral sensitivity inferred from the prevalence-luminance relationship is not scotopic, and (3) the prevalence-luminance relationship does not behave univariantly under all chromatic conditions. We conclude that rod signals alone do not control field prevalence.

  19. Interface Defeat of Long-Rod Projectiles by Ceramic Armor

    DTIC Science & Technology

    2005-09-01

    Interface Defeat of Long-Rod Projectiles by Ceramic Armor by George E. Hauver, Edward J. Rapacki, Jr., Paul H. Netherwood, and Ralph F. Benck...21005-5066 ARL-TR-3590 September 2005 Interface Defeat of Long-Rod Projectiles by Ceramic Armor George E. Hauver, Edward J. Rapacki, Jr...NUMBER 4. TITLE AND SUBTITLE Interface Defeat of Long-Rod Projectiles by Ceramic Armor 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER

  20. COMPUTER MODEL OF TEMPERATURE DISTRIBUTION IN OPTICALLY PUMPED LASER RODS

    NASA Technical Reports Server (NTRS)

    Farrukh, U. O.

    1994-01-01

    Managing the thermal energy that accumulates within a solid-state laser material under active pumping is of critical importance in the design of laser systems. Earlier models that calculated the temperature distribution in laser rods were single dimensional and assumed laser rods of infinite length. This program presents a new model which solves the temperature distribution problem for finite dimensional laser rods and calculates both the radial and axial components of temperature distribution in these rods. The modeled rod is either side-pumped or end-pumped by a continuous or a single pulse pump beam. (At the present time, the model cannot handle a multiple pulsed pump source.) The optical axis is assumed to be along the axis of the rod. The program also assumes that it is possible to cool different surfaces of the rod at different rates. The user defines the laser rod material characteristics, determines the types of cooling and pumping to be modeled, and selects the time frame desired via the input file. The program contains several self checking schemes to prevent overwriting memory blocks and to provide simple tracing of information in case of trouble. Output for the program consists of 1) an echo of the input file, 2) diffusion properties, radius and length, and time for each data block, 3) the radial increments from the center of the laser rod to the outer edge of the laser rod, and 4) the axial increments from the front of the laser rod to the other end of the rod. This program was written in Microsoft FORTRAN77 and implemented on a Tandon AT with a 287 math coprocessor. The program can also run on a VAX 750 mini-computer. It has a memory requirement of about 147 KB and was developed in 1989.

  1. Biophysical mechanism of transient retinal phototropism in rod photoreceptors.

    PubMed

    Zhao, Xiaohui; Thapa, Damber; Wang, Benquan; Gai, Shaoyan; Yao, Xincheng

    2016-02-13

    Oblique light stimulation evoked transient retinal phototropism (TRP) has been recently detected in frog and mouse retinas. High resolution microscopy of freshly isolated retinas indicated that the TRP is predominated by rod photoreceptors. Comparative confocal microscopy and optical coherence tomography (OCT) revealed that the TRP predominantly occurred from the photoreceptor outer segment (OS). However, biophysical mechanism of rod OS change is still unknown. In this study, frog retinal slices, which open a cross section of retinal photoreceptor and other functional layers, were used to test the effect of light stimulation on rod OS. Near infrared light microscopy was employed to monitor photoreceptor changes in retinal slices stimulated by a rectangular-shaped visible light flash. Rapid rod OS length change was observed after the stimulation delivery. The magnitude and direction of the rod OS change varied with the position of the rods within the stimulated area. In the center of stimulated region the length of the rod OS shrunk, while in the peripheral region the rod OS tip swung towards center region in the plane perpendicular to the incident stimulus light. Our experimental result and theoretical analysis suggest that the observed TRP may reflect unbalanced disc-shape change due to localized pigment bleaching. Further investigation is required to understand biochemical mechanism of the observed rod OS kinetics. Better study of the TRP may provide a noninvasive biomarker to enable early detection of age-related macular degeneration (AMD) and other diseases that are known to produce retinal photoreceptor dysfunctions.

  2. Pultruded Rod/Overwrap Testing for Various Stitched Stringer Configurations

    NASA Technical Reports Server (NTRS)

    Leone, Frank A., Jr.

    2016-01-01

    The unidirectional carbon pultruded rod running through the tops of the stringers is a key design feature of the Pultruded Rod Efficient Unitized Structure (PRSEUS) concept as applied to aircraft fuselage structure. Reported herein are the test methods and results from a test campaign in which the strength of the rod/overwrap interface of various PRSEUS stringer configurations were characterized. The different stringer configurations included different materials and stacking sequences for the stringer overwrap and whether or not an additional layer of adhesive was included between the rod and the overwrap.

  3. Biophysical mechanism of transient retinal phototropism in rod photoreceptors

    NASA Astrophysics Data System (ADS)

    Zhao, Xiaohui; Thapa, Damber; Wang, Benquan; Gai, Shaoyan; Yao, Xincheng

    2016-03-01

    Oblique light stimulation evoked transient retinal phototropism (TRP) has been recently detected in frog and mouse retinas. High resolution microscopy of freshly isolated retinas indicated that the TRP is predominated by rod photoreceptors. Comparative confocal microscopy and optical coherence tomography (OCT) revealed that the TRP predominantly occurred from the photoreceptor outer segment (OS). However, biophysical mechanism of rod OS change is still unknown. In this study, frog retinal slices, which open a cross section of retinal photoreceptor and other functional layers, were used to test the effect of light stimulation on rod OS. Near infrared light microscopy was employed to monitor photoreceptor changes in retinal slices stimulated by a rectangular-shaped visible light flash. Rapid rod OS length change was observed after the stimulation delivery. The magnitude and direction of the rod OS change varied with the position of the rods within the stimulated area. In the center of stimulated region the length of the rod OS shrunk, while in the peripheral region the rod OS tip swung towards center region in the plane perpendicular to the incident stimulus light. Our experimental result and theoretical analysis suggest that the observed TRP may reflect unbalanced disc-shape change due to localized pigment bleaching. Further investigation is required to understand biochemical mechanism of the observed rod OS kinetics. Better study of the TRP may provide a noninvasive biomarker to enable early detection of age-related macular degeneration (AMD) and other diseases that are known to produce retinal photoreceptor dysfunctions.

  4. The evaluation of corrosion resistant rod end rolling element bearings

    SciTech Connect

    Braza, J.F.; Giuntoli, K.; Imundo, J.R.

    1998-12-31

    Recent developments on carburizing grades of stainless steels have provided new materials to produce corrosion resistant airframe control bearings. This paper presents the application of one of these new carburizing grades of stainless steel to rod end ball bearings. The outer ring of the rod end bearing is made out of carburized stainless steel, while the inner ring and balls are made out of through-hardened stainless steel. The stainless steel rod end bearings were evaluated according to various ASTM and Military specifications for performance and corrosion resistance. The stainless steel rod end bearings exceeded the performance requirements of standard rod end bearings (which are comprised of a carburized 8620 steel outer ring and 52100 steel inner ring and balls) in accordance with MIL-B-6039. The rod end bearings were evaluated in the radial fracture load, axial fracture load, and radial dynamic load tests. Also, salt spray and alternate immersion corrosion tests (ASTM B 117-85 and G 44-88, respectively) were conducted on the stainless steel rod end bearings. The stainless steel rod end bearings exhibited superior corrosion resistance to the standard 8620/52100 steel rod end bearings.

  5. Transient elastic impact response of slender graphite rods

    SciTech Connect

    Erdem, I.

    2007-12-15

    Graphite rods are manufactured by extruding the mixture of calcined petroleum coke and coal tar pitch into the desired shape and baking the cooled specimens at about 800{sup o}C. Cracking can occur in rods during the manufacturing process. It is useful to be able to detect the presence of such cracks in the rods prior to their being machined and put into use as electrodes or cathodes or thermal insulator. In an effort to develop a nondestructive testing approach to evaluation of the rods, transient elastic impact was determined for slender rods. Theory for solid, slender rods provided an important starting point for this work. Subsequently, numerical models were developed and simulation was used to determine the response of rods containing cracks. Experiments on graphite rods with and without cracks were conducted and the internal condition determined from the recorded signals. The rods were then cut lengthwise to reveal the internal condition and verify the predicted results. In all cases the knowledge gained from simulation allowed for the presence of cracks to be detected.

  6. Application of polyimide actuator rod seals

    NASA Technical Reports Server (NTRS)

    Watermann, A. W.; Gay, B. F.; Robinson, E. D.; Srinath, S. K.; Nelson, W. G.

    1972-01-01

    Development of polyimide two-stage hydraulic actuator rod seals for application in high-performance aircraft was accomplished. The significant portion of the effort was concentrated on optimization of the chevron and K-section second-stage seal geometries to satisfy the requirements for operation at 450 K (350 F) with dynamic pressure loads varying between 200 psig steady-state and 1500 psig impulse cycling. Particular significance was placed on reducing seal gland dimension by efficiently utilizing the fatigue allowables of polyimide materials. Other objectives included investigation of pressure balancing techniques for first-stage polyimide rod seals for 4000 psig 450 K(350 F) environment and fabrication of a modular retainer for the two-stage combination. Seals were fabricated in 0.0254 m (1.0in.) and 0.0635 m (2.5in.) sizes and tested for structural integrity, frictional resistance, and endurance life. Test results showed that carefully designed second stages using polyimides could be made to satisfy the dynamic return pressure requirements of applications in high-performance aircraft. High wear under full system pressure indicated that further research is necessary to obtain an acceptable first-stage design. The modular retainer was successfully tested and showed potential for new actuator applications.

  7. Fluid Dynamics in Sucker Rod Pumps

    SciTech Connect

    Cutler, Robert P.; Mansure, Arthur J.

    1999-06-01

    Sucker rod pumps are installed in approximately 90% of all oil wells in the U.S. Although they have been widely used for decades, there are many issues regarding the fluid dynamics of the pump that have not been filly investigated. A project was conducted at Sandia National Laboratories to develop an improved understanding of the fluid dynamics inside a sucker rod pump. A mathematical flow model was developed to predict pressures in any pump component or an entire pump under single-phase fluid and pumping conditions. Laboratory flow tests were conducted on instrumented individual pump components and on a complete pump to verifi and refine the model. The mathematical model was then converted to a Visual Basic program to allow easy input of fluid, geometry and pump parameters and to generate output plots. Examples of issues affecting pump performance investigated with the model include the effects of viscosity, surface roughness, valve design details, plunger and valve pressure differentials, and pumping rate.

  8. Laser decontamination of the radioactive lightning rods

    NASA Astrophysics Data System (ADS)

    Potiens, A. J.; Dellamano, J. C.; Vicente, R.; Raele, M. P.; Wetter, N. U.; Landulfo, E.

    2014-02-01

    Between 1970 and 1980 Brazil experienced a significant market for radioactive lightning rods (RLR). The device consists of an air terminal with one or more sources of americium-241 attached to it. The sources were used to ionize the air around them and to increase the attraction of atmospheric discharges. Because of their ineffectiveness, the nuclear regulatory authority in Brazil suspended the license for manufacturing, commerce and installation of RLR in 1989, and determined that the replaced RLR were to be collected to a centralized radioactive waste management facility for treatment. The first step for RLR treatment is to remove the radioactive sources. Though they can be easily removed, some contaminations are found all over the remaining metal scrap that must decontaminated for release, otherwise it must be treated as radioactive waste. Decontamination using various chemicals has proven to be inefficient and generates large amounts of secondary wastes. This work shows the preliminary results of the decontamination of 241Am-contaminated metal scrap generated in the treatment of radioactive lightning rods applying laser ablation. A Nd:YAG nanoseconds laser was used with 300 mJ energy leaving only a small amount of secondary waste to be treated.

  9. Condensation transition in polydisperse hard rods.

    PubMed

    Evans, M R; Majumdar, S N; Pagonabarraga, I; Trizac, E

    2010-01-07

    We study a mass transport model, where spherical particles diffusing on a ring can stochastically exchange volume v, with the constraint of a fixed total volume V= sum(i=1) (N)v(i), N being the total number of particles. The particles, referred to as p-spheres, have a linear size that behaves as v(i) (1/p) and our model thus represents a gas of polydisperse hard rods with variable diameters v(i) (1/p). We show that our model admits a factorized steady state distribution which provides the size distribution that minimizes the free energy of a polydisperse hard-rod system, under the constraints of fixed N and V. Complementary approaches (explicit construction of the steady state distribution on the one hand; density functional theory on the other hand) completely and consistently specify the behavior of the system. A real space condensation transition is shown to take place for p>1; beyond a critical density a macroscopic aggregate is formed and coexists with a critical fluid phase. Our work establishes the bridge between stochastic mass transport approaches and the optimal polydispersity of hard sphere fluids studied in previous articles.

  10. Homogeneous cooling state of frictionless rod particles

    NASA Astrophysics Data System (ADS)

    Rubio-Largo, S. M.; Alonso-Marroquin, F.; Weinhart, T.; Luding, S.; Hidalgo, R. C.

    2016-02-01

    In this work, we report some theoretical results on granular gases consisting of frictionless 3D rods with low energy dissipation. We performed simulations on the temporal evolution of soft spherocylinders, using a molecular dynamics algorithm implemented on GPU architecture. A homogeneous cooling state for rods, where the time dependence of the system's intensive variables occurs only through a global granular temperature, has been identified. We have found a homogeneous cooling process, which is in excellent agreement with Haff's law, when using an adequate rescaling time τ(ξ), the value of which depends on the particle elongation ξ and the restitution coefficient. It was further found that scaled particle velocity distributions remain approximately Gaussian regardless of the particle shape. Similarly to a system of ellipsoids, energy equipartition between rotational and translational degrees of freedom was better satisfied as one gets closer to the elastic limit. Taking advantage of scaling properties, we have numerically determined the general functionality of the magnitude Dc(ξ), which describes the efficiency of the energy interchange between rotational and translational degrees of freedom, as well as its dependence on particle shape. We have detected a range of particle elongations (1.5 < ξ < 4.0), where the average energy transfer between the rotational and translational degrees of freedom results greater for spherocylinders than for homogeneous ellipsoids with the same aspect ratio.

  11. An elastic rod model for anguilliform swimming.

    PubMed

    McMillen, T; Holmes, P

    2006-11-01

    We develop a model for anguilliform (eel-like) swimming as an elastic rod actuated via time-dependent intrinsic curvature and subject to hydrodynamic drag forces, the latter as proposed by Taylor (in Proc Roy Proc Lond A 214:158-183, 1952). We employ a eometrically exact theory and discretize the resulting nonlinear partial differential evolution both to perform numerical simulations, and to compare with previous models consisting of chains of rigid links or masses connected by springs, dampers, and prescribed force generators representing muscles. We show that muscle activations driven by motoneuronal spike trains via calcium dynamics produce intrinsic curvatures corresponding to near-sinusoidal body shapes in longitudinally-uniform rods, but that passive elasticity causes Taylor's assumption of prescribed shape to fail, leading to time-periodic motions and lower speeds than those predicted Taylor (in Proc Roy Proc Lond A 214:158-183, 1952). We investigate the effects of bending stiffness, body geometry, and activation patterns on swimming speed, turning behavior, and acceleration to steady swimming. We show that laterally-uniform activation yields stable straight swimming and laterally differential activation levels lead to stable turns, and we argue that tapered bodies with reduced caudal (tail-end) activation (to produce uniform intrinsic curvature) swim faster than ones with uniform activation.

  12. Pressure reducing regulator

    DOEpatents

    Whitehead, J.C.; Dilgard, L.W.

    1995-10-10

    A pressure reducing regulator that controls its downstream or outlet pressure to a fixed fraction of its upstream or inlet pressure is disclosed. The regulator includes a housing which may be of a titanium alloy, within which is located a seal or gasket at the outlet end which may be made of annealed copper, a rod, and piston, each of which may be made of high density graphite. The regulator is insensitive to temperature by virtue of being without a spring or gas sealed behind a diaphragm, and provides a reference for a system in which it is being used. The rod and piston of the regulator are constructed, for example, to have a 1/20 ratio such that when the downstream pressure is less than 1/20 of the upstream pressure the regulator opens and when the downstream pressure exceeds 1/20 of the upstream pressure the regulator closes. 10 figs.

  13. Pressure reducing regulator

    DOEpatents

    Whitehead, John C.; Dilgard, Lemoyne W.

    1995-01-01

    A pressure reducing regulator that controls its downstream or outlet pressure to a fixed fraction of its upstream or inlet pressure. The regulator includes a housing which may be of a titanium alloy, within which is located a seal or gasket at the outlet end which may be made of annealed copper, a rod, and piston, each of which may be made of high density graphite. The regulator is insensitive to temperature by virtue of being without a spring or gas sealed behind a diaphragm, and provides a reference for a system in which it is being used. The rod and piston of the regulator are constructed, for example, to have a 1/20 ratio such that when the downstream pressure is less than 1/20 of the upstream pressure the regulator opens and when the downstream pressure exceeds 1/20 of the upstream pressure the regulator closes.

  14. Self-assembly of cyclic rod-coil diblock copolymers.

    PubMed

    He, Linli; Chen, Zenglei; Zhang, Ruifen; Zhang, Linxi; Jiang, Zhouting

    2013-03-07

    The phase behavior of cyclic rod-coil diblock copolymer melts is investigated by the dissipative particle dynamics simulation. In order to understand the effect of chain topological architecture better, we also study the linear rod-coil system. The comparison of the calculated phase diagrams between the two rod-coil copolymers reveals that the order-disorder transition point (χN)ODT for cyclic rod-coil diblock copolymers is always higher than that of equivalent linear rod-coil diblocks. In addition, the phase diagram for cyclic system is more "symmetrical," due to the topological constraint. Moreover, there are significant differences in the self-assembled overall morphologies and the local molecular arrangements. For example, frod = 0.5, both lamellar structures are formed while rod packing is different greatly in cyclic and linear cases. The lamellae with rods arranged coplanarly into bilayers occurs in cyclic rod-coil diblocks, while the lamellar structure with rods arranged end by end into interdigitated bilayers appears in linear counterpart. In both the lamellar phases, the domain size ratio of cyclic to linear diblocks is ranged from 0.63 to 0.70. This is attributed to that the cyclic architecture with the additional junction increases the contacts between incompatible blocks and prevents the coil chains from expanding as much as the linear cases. As frod = 0.7, the hexagonally packed cylinder is observed for cyclic rod-coil diblocks, while liquid-crystalline smectic A lamellar phase is formed in linear system. As a result, the cyclization of a linear rod-coil block copolymer can induce remarkable differences in the self-assembly behavior and also diversify its physical properties and applications greatly.

  15. Switch isotropic/anisotropic wettability via dual-scale rods

    NASA Astrophysics Data System (ADS)

    He, Yang; Jiang, Chengyu; Wang, Shengkun; Ma, Zhibo; Yuan, Weizheng

    2014-10-01

    It is the first time to demonstrate the comparison of isotropic/anisotropic wettability between dual-scale micro-nano-rods and single-scale micro-rods. Inspired by the natural structures of rice leaf, a series of micro-nano-rods and micro-rods with different geometric parameters were fabricated using micro-fabrication technology. Experimental measured apparent contact angles and advancing and receding contact angles from orthogonal orientations were characterized. The difference of contact angles from orthogonal orientation on dual-scale rods was much smaller than those on single-scale rods in both static and dynamic situation. It indicated that the dual-scale micro-nano-rods showed isotropic wettability, while single-scale micro-rods showed anisotropic wettability. The switch of isotropic/anisotropic wettability could be illustrated by different wetting state and contact line moving. It offers a facial way to switch isotropic/anisotropic wettability of the surface via dual-scale or single-scale structure.

  16. Experimental diffusion measurements of entangled rod-coil block copolymers

    NASA Astrophysics Data System (ADS)

    Wang, Muzhou; Timachova, Ksenia; Alexander-Katz, Alfredo; Olsen, Bradley

    2013-03-01

    A fundamental theory for the dynamics of rod-coil block copolymers is important for understanding diffusion, mechanics, and self-assembly kinetics in functional nanostructured materials for organic electronics and biomaterials. Recently our group has proposed a reptation theory for the diffusion of entangled rod-coil block copolymers, showing the slower dynamics of rod-coils is due to the mismatch between the curvature of the rod and coil blocks. Here we present experimental tracer diffusion measurements of model rod-coil diblock and coil-rod-coil triblock copolymers that support this theory. The model systems are composed of poly(ethylene oxide) coils and polyalanine α-helical rods synthesized by bacterial expression and bioconjugation, and tracer diffusion in entangled solutions is measured by forced Rayleigh scattering. The experiments support both the activated reptation and arm retraction mechanism for the small and large rod regimes that were previously presented in our theory. Comparison of both simulation and experiments between diblock and triblock copolymers suggests that the diffusion mechanisms are independent of the different symmetry and molecular architecture of the molecules.

  17. 32 CFR 989.21 - Record of decision (ROD).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Record of decision (ROD). 989.21 Section 989.21 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION... Final EIS in the Federal Register. (b) The Air Force must announce the ROD to the affected public as...

  18. 32 CFR 989.21 - Record of decision (ROD).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Record of decision (ROD). 989.21 Section 989.21 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION... Final EIS in the Federal Register. (b) The Air Force must announce the ROD to the affected public as...

  19. 32 CFR 989.21 - Record of decision (ROD).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Record of decision (ROD). 989.21 Section 989.21 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION... Final EIS in the Federal Register. (b) The Air Force must announce the ROD to the affected public as...

  20. 32 CFR 989.21 - Record of decision (ROD).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Record of decision (ROD). 989.21 Section 989.21 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION... Final EIS in the Federal Register. (b) The Air Force must announce the ROD to the affected public as...

  1. CONTROL ROD FOR A NUCLEAR REACTOR AND METHOD OF PREPARATION

    DOEpatents

    Hausner, H.H.

    1958-12-30

    BS>An improved control rod is presented for a nuclear reactor. This control rod is comprised of a rare earth metal oxide or rare earth metal carbide such as gadolinium oxide or gadolinium carbide, uniformly distributed in a metal matrix having a low cross sectional area of absorption for thermal neutrons, such as aluminum, beryllium, and zirconium.

  2. Approximation in LQG control of a thermoelastic rod

    NASA Technical Reports Server (NTRS)

    Gibson, J. S.; Rosen, I. G.; Tao, G.

    1989-01-01

    Control and estimator gains are computed for linear-quadratic-Gaussian (LQG) optimal control of the axial vibrations of a thermoelastic rod. The computations are based on a modal approximation of the partial differential equations representing the rod, and convergence of the approximations to control and estimator gains is the main issue.

  3. Strategy Access Rods: A Hands-On Approach.

    ERIC Educational Resources Information Center

    Worthing, Bernadette; Laster, Barbara

    2002-01-01

    Describes Strategy Access Rods (SARs), balsa-wood, prism-like or rectangular rods on which a one-sentence reading strategy phrase in the first person is printed. Notes SARs serve as a visual, auditory, kinesthetic, and tactile reminder of the strategies available to developing readers. Discusses use of SARs for word recognition and comprehension.…

  4. Packed rod neutron shield for fast nuclear reactors

    DOEpatents

    Eck, John E.; Kasberg, Alvin H.

    1978-01-01

    A fast neutron nuclear reactor including a core and a plurality of vertically oriented neutron shield assemblies surrounding the core. Each assembly includes closely packed cylindrical rods within a polygonal metallic duct. The shield assemblies are less susceptible to thermal stresses and are less massive than solid shield assemblies, and are cooled by liquid coolant flow through interstices among the rods and duct.

  5. Strategy Access Rods: A Hands-On Approach.

    ERIC Educational Resources Information Center

    Worthing, Bernadette; Laster, Barbara

    2002-01-01

    Describes Strategy Access Rods (SARs), balsa-wood, prism-like or rectangular rods on which a one-sentence reading strategy phrase in the first person is printed. Notes SARs serve as a visual, auditory, kinesthetic, and tactile reminder of the strategies available to developing readers. Discusses use of SARs for word recognition and comprehension.…

  6. Bond of fiber reinforced plastic (FRP) rods to concrete

    SciTech Connect

    Al-Zahrani, M.M.; Nanni, A.; Al-Dulaijan, S.U.; Bakis, C.E.

    1996-11-01

    The bond behavior between FRP rods and concrete is one of the most important aspects to predicting the short- and long-term performance of FRP reinforced concrete structures including development and transfer length. In this research, the direct pull-out test was used to study the FRP/concrete bond behavior. This method allows measurement of the loaded- and free-end slip of the FRP rod and placement of a strain probe inside the rod to measure internal strain distribution in both axial and radial directions along the bonded length without affecting the FRP/concrete interface. Knowledge of strain distribution is necessary to study the load transfer mechanism between FRP rod and concrete. The scope of this paper include experimental results obtained with the direct pull-out test using 12.7 mm glass and carbon FRP rods with smooth and axisymmetrical deformed surfaces. The typical results are given as nominal bond and shear stress vs. free- and loaded-end slip. Experimental results obtained from strain probes used during pull-out tests are also presented as nominal bond and shear stress vs. strain. For smooth rods, friction is the main controlling factor. For deformed rods, bond tends to be controlled by strength and mechanical action of the axisymmetrical deformations rather than adhesion and friction. The strength of concrete appears to have no effect on the bond strength and failure mechanism of these particular machined FRP rods when concrete splitting is avoided.

  7. 32 CFR 989.21 - Record of decision (ROD).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Record of decision (ROD). 989.21 Section 989.21 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.21 Record of decision (ROD). (a) The proponent and the...

  8. Nuclear reactor shutdown control rod assembly

    DOEpatents

    Bilibin, Konstantin

    1988-01-01

    A temperature responsive, self-actuated nuclear reactor shutdown control rod assembly 10. The upper end 18 of a lower drive line 17 fits within the lower end of an upper drive line 12. The lower end (not shown) of the lower drive line 17 is connected to a neutron absorber. During normal temperature conditions the lower drive line 17 is supported by detent means 22,26. When an overtemperature condition occurs thermal actuation means 34 urges ring 26 upwardly sufficiently to allow balls 22 to move radially outwardly thereby allowing lower drive line 17 to move downwardly toward the core of the nuclear reactor resulting in automatic reduction of the reactor powder.

  9. Electric Fuel Rod Simulator Fabrication at ORNL

    SciTech Connect

    Ott, Larry J.; McCulloch, Reg

    2004-02-04

    Commercial vendors could not supply the high-quality, highly instrumented electric fuel rod simulators (FRS) required for large thermal-hydraulic safety-oriented experiments at the Oak Ridge National Laboratory (ORNL) in the 1970s and early 1980s. Staff at ORNL designed, developed, and manufactured the simulators utilized in these safety experiments. Important FRS design requirements include (1) materials of construction, (2) test power requirements and availability, (3) experimental test objectives, (4) supporting thermal analyses, and (5) extensive quality control throughout all phases of FRS fabrication. This paper will present an overview of these requirements (design, analytics, and quality control) as practiced at ORNL to produce a durable high-quality FRS.

  10. Trapping and sorting active granular rods

    NASA Astrophysics Data System (ADS)

    Ramaswamy, Sriram; Kumar, Nitin; Soni, Harsh; Gupta, Rahul; Sood, Ajay

    We report experiments and simulations on collective trapping in a horizontal monolayer of tapered granular rods rendered motile by mechanical vibration. A macroscopic fraction of the particles are trapped by a V-shaped obstacle if its opening angle is less than a threshold value of about 120 degrees, consistent with active Brownian simulations [PRL 108, 268307 (2012)]. the transition between trapped and untrapped states becomes sharper with increasing system size in our numerical studies. We offer a theoretical understanding of this nonequilibrium phase transition based on collective noise suppression and an analysis of fluxes. We show also that the trap can serve to separate particles based on their motility and rotational diffusivity. On leave from Dept of Physics, Indian Institute of Science.

  11. Biomolecular rods and tubes in nanotechnology

    NASA Astrophysics Data System (ADS)

    Bittner, Alexander M.

    2005-02-01

    Biomolecules are vitally important elements in nanoscale science and also in future nanotechnology. Their shape and their chemical and physical functionality can give them a big advantage over inorganic and organic substances. While this becomes most obvious in proteins and peptides, with their complicated, but easily controlled chemistry, other biomolecular substances such as DNA, lipids and carbohydrates can also be important. In this review, the emphasis is on one-dimensional molecules and on molecules that self-assemble into linear structures, and on their potential applications. An important aspect is that biomolecules can act as templates, i.e. their shape and chemical properties can be employed to arrange inorganic substances such as metals or metal compounds on the nanometre scale. In particular, rod- and tube-like nanostructures can show physical properties that are different from those of the bulk material, and thus these structures are likely to be a basis for new technology.

  12. Biomolecular rods and tubes in nanotechnology.

    PubMed

    Bittner, Alexander M

    2005-02-01

    Biomolecules are vitally important elements in nanoscale science and also in future nanotechnology. Their shape and their chemical and physical functionality can give them a big advantage over inorganic and organic substances. While this becomes most obvious in proteins and peptides, with their complicated, but easily controlled chemistry, other biomolecular substances such as DNA, lipids and carbohydrates can also be important. In this review, the emphasis is on one-dimensional molecules and on molecules that self-assemble into linear structures, and on their potential applications. An important aspect is that biomolecules can act as templates, i.e. their shape and chemical properties can be employed to arrange inorganic substances -- such as metals or metal compounds -- on the nanometre scale. In particular, rod- and tube-like nanostructures can show physical properties that are different from those of the bulk material, and thus these structures are likely to be a basis for new technology.

  13. Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.

    PubMed

    Herrmann, Rolf; Heflin, Stephanie J; Hammond, Timothy; Lee, Bowa; Wang, Jing; Gainetdinov, Raul R; Caron, Marc G; Eggers, Erika D; Frishman, Laura J; McCall, Maureen A; Arshavsky, Vadim Y

    2011-10-06

    Dark and light adaptation of retinal neurons allow our vision to operate over an enormous light intensity range. Here we report a mechanism that controls the light sensitivity and operational range of rod-driven bipolar cells that mediate dim-light vision. Our data indicate that the light responses of these cells are enhanced by sustained chloride currents via GABA(C) receptor channels. This sensitizing GABAergic input is controlled by dopamine D1 receptors, with horizontal cells serving as a plausible source of GABA release. Our findings expand the role of dopamine in vision from its well-established function of suppressing rod-driven signals in bright light to enhancing the same signals under dim illumination. They further reveal a role for GABA in sensitizing the circuitry for dim-light vision, thereby complementing GABA's traditional role in providing dynamic feedforward and feedback inhibition in the retina.

  14. Damage development in rod-on-rod impact test on 1100 pure aluminum

    NASA Astrophysics Data System (ADS)

    Iannitti, G.; Bonora, N.; Bourne, N.; Ruggiero, A.; Testa, G.

    2017-01-01

    Stress triaxiality plays a major role in the nucleation and growth of ductile damage in metals and alloys. Although, the mechanisms responsible for ductile failure are the same at low and high strain rate, in impact dynamics, in addition to time resolved stress triaxiality and plastic strain accumulation, pressure also contributes to establish the condition for ductile failure to occur. In this work, ductile damage development in 1100 commercially pure aluminum was investigated by means of rod-on-rod (ROR) impact tests. Based on numerical simulations, using a continuum damage mechanics (CDM) model that accounts for the role of pressure on damage parameters and stochastic variability of such parameters, the impact velocity for no damage, incipient and fully developed damage were estimated. ROR tests at selected velocities were performed and damage distribution and extent were investigated by sectioning of soft recovered samples. Comparison between numerical simulations and experimental results is presented and discussed.

  15. Influence of convection on rod spacing of eutectics

    NASA Technical Reports Server (NTRS)

    Caram, R.; Chandrasekhar, S.; Wilcox, W. R.

    1990-01-01

    This paper describes a three-dimensional numerical model to study the influence of convection on the rod-like microstructure of an eutectic system. This model is based on a central finite difference approach. By applying it, the average concentration near the solid/liquid interface of a growing rod-like eutectic was determined for eutectic compositions C(e) of 0.03, 0.05, and 0.10. Following Jackson and Hunt (1966), the average interfacial composition was converted to a change of undercooling at the interface and, finally, to spacing between the rods. The change in rod spacing with increasing intensity of convection was calculated assuming the eutectic grows at minimum interfacial undercooling. It was confirmed that an increase in convection should coarsen the microstructure (i.e., the rod spacing increases with increasing intensity of stirring).

  16. Fatigue Life Improving of Drill Rod by Inclusion Control

    NASA Astrophysics Data System (ADS)

    Wang, Linzhu; Yang, Shufeng; Li, Jingshe; Liu, Wei; Zhou, Yinghao

    2016-08-01

    Large and hard inclusions often deteriorate the service performance and reduce the fatigue lifetime of drill rods. In this paper, the main reasons of the rupture of drill rods were analyzed by the examination of their fracture and it is found that the large inclusions were the main reason of breakage of rod drill. The inclusions were high of Ca content or Al2O3 rich. Smaller and better deformability inclusions were obtained by the optimization of refining slag, calcium treatment process and the flow control devices of tundish. Results of industrial experiment after optimization show that total oxygen content of drill rods decreased by more than 50%, macro-inclusions weight fraction decreased from about 4 mg/10 kg to about 0.3 mg/10 kg and the micro-inclusions average size decreased from 6 to 3.6 μm. The average using times of drill rods after optimization were increased by about 60%.

  17. Control wetting state transition by micro-rod geometry

    NASA Astrophysics Data System (ADS)

    He, Yang; Jiang, Chengyu; Wang, Shengkun; Yin, Hengxu; Yuan, Weizheng

    2013-11-01

    Understanding the effect of micro-structure geometry on wetting state transition is important to design and control surface wettability. Micro-rod model was proposed and the relationship between micro-rod geometry and wetting state was investigated in the paper taking into account only the surface roughness and neglecting the chemistry interaction. Micro-rods with different geometric parameters were fabricated using micro-fabrication technology. Their contact angles were measured and compared with theoretical ones. The experimental results indicated that increasing the height and decreasing the space of micro-rod may result in Cassie wetting state, while decreasing the height and increasing the space may result in Wenzel wetting state. A suspended wetting state model due to scallops was proposed. The wetting state transition was interpreted by intruding height, de-pinning and sag mechanism. It may offer a facile way to control the surface wetting state transition by changing the geometry of micro-rod.

  18. Semiconductor Quantum Rods as Single Molecule FluorescentBiological Labels

    SciTech Connect

    Fu, Aihua; Gu, Weiwei; Boussert, Benjamine; Koski, Kristie; Gerion, Daniele; Manna, Liberato; Le Gros, Mark; Larabell, Carolyn; Alivisatos, A. Paul

    2006-05-29

    In recent years, semiconductor quantum dots have beenapplied with great advantage in a wide range of biological imagingapplications. The continuing developments in the synthesis of nanoscalematerials and specifically in the area of colloidal semiconductornanocrystals have created an opportunity to generate a next generation ofbiological labels with complementary or in some cases enhanced propertiescompared to colloidal quantum dots. In this paper, we report thedevelopment of rod shaped semiconductor nanocrystals (quantum rods) asnew fluorescent biological labels. We have engineered biocompatiblequantum rods by surface silanization and have applied them fornon-specific cell tracking as well as specific cellular targeting. Theproperties of quantum rods as demonstrated here are enhanced sensitivityand greater resistance for degradation as compared to quantum dots.Quantum rods have many potential applications as biological labels insituations where their properties offer advantages over quantumdots.

  19. Interfacial colloidal rod dynamics: Coefficients, simulations, and analysis

    NASA Astrophysics Data System (ADS)

    Yang, Yuguang; Bevan, Michael A.

    2017-08-01

    Colloidal rod diffusion near a wall is modeled and simulated based on a constrained Stokesian dynamic model of chains-of-spheres. By modeling colloidal rods as chains-of-spheres, complete diffusion tensors are computed for colloidal rods in bulk media and near interfaces, including hydrodynamic interactions, translation-rotation coupling, and all diffusion modes in the particle and lab frames. Simulated trajectories based on the chain-of-spheres diffusion tensor are quantified in terms of typical experimental quantities such as mean squared positional and angular displacements as well as autocorrelation functions. Theoretical expressions are reported to predict measured average diffusivities as well as the crossover from short-time anisotropic translational diffusion along the rod's major axis to isotropic diffusion. Diffusion modes are quantified in terms of closed form empirical fits to model results to aid their use in interpretation and prediction of experiments involving colloidal rod diffusion in interfacial and confined systems.

  20. Simplified modeling of the EBR-II control rods

    SciTech Connect

    Angelo, P.L.

    1995-06-25

    Simplified models of EBR-II control and safety rods have been developed for core modeling under various operational and shutdown conditions. A parametric study was performed on normal worth, high worth, and safety rod type control rods. A summary of worth changes due to individual modeling approximations is tabulated. Worth effects due to structural modeling simplification are negligible. Fuel region homogenization and burnup compression contributes more than any other factor. Reference case C/E values (ratio of calculated worth from detailed model to measured worth) of 1.072 and 1.142 for safety and normal worth rods indicate acceptable errors when the approximations are used. Fuel burnup effect illustrates rod worth sensitivity to the modeling approximation. Aggregate effects are calculated under a reduced mesh.

  1. Random geometric graph description of connectedness percolation in rod systems.

    PubMed

    Chatterjee, Avik P; Grimaldi, Claudio

    2015-09-01

    The problem of continuum percolation in dispersions of rods is reformulated in terms of weighted random geometric graphs. Nodes (or sites or vertices) in the graph represent spatial locations occupied by the centers of the rods. The probability that an edge (or link) connects any randomly selected pair of nodes depends upon the rod volume fraction as well as the distribution over their sizes and shapes, and also upon quantities that characterize their state of dispersion (such as the orientational distribution function). We employ the observation that contributions from closed loops of connected rods are negligible in the limit of large aspect ratios to obtain percolation thresholds that are fully equivalent to those calculated within the second-virial approximation of the connectedness Ornstein-Zernike equation. Our formulation can account for effects due to interactions between the rods, and many-body features can be partially addressed by suitable choices for the edge probabilities.

  2. Investigating the optical XNOR gate using plasmonic nano-rods

    NASA Astrophysics Data System (ADS)

    Akhlaghi, Majid; Kaboli, Milad

    2016-04-01

    In this paper, a coherent perfect absorption (CPA)-type XNOR gate based on plasmonic nano particle is proposed. It consists of two plasmonic nano rod arrays on top of two parallel arms with quartz substrate. The operation principle is based on the absorbable formation of a conductive path in the dielectric layer of a plasmonic nano-particles waveguide. Since the CPA efficiency depends strongly on the number of plasmonic nano-rod and the nano rod location, an efficient binary optimization method based the Particle Swarm Optimization (PSO) algorithm is used to design an optimized array of the plasmonic nano-rod in order to achieve the maximum absorption coefficient in the 'off' state and the minimum absorption coefficient in the 'on' state. In Binary PSO (BPSO), a group of birds consists a matrix with binary entries, control the presence ('1‧) or the absence ('0‧) of nano rod in the array.

  3. Study of the anti-sand sucker rod pump

    NASA Astrophysics Data System (ADS)

    Wei, Hangxin; Lv, Bingxin; Xi, Wenkui; Yi, Peng

    2017-06-01

    In order to solve the problem of sand stuck in the sucker rod pump, an anti-sand sucker rod pump is designed. The anti-sand sucker rod pump includes the conventional sucker rod pump and the swirl flow device. The sand particles can be separated from the oil in the swirl flow device, so the plunger of the sucker rod pump cannot be stuck. The motion equation of the sand particles in oil is deduced. The virtual model of the swirl flow device is built in GAMBIT software. And simulation of solid-liquid two phase flow is simulated in software FLUENT. The simulation results show that the swirl flow device can realize the sand particles separation from the oil completely. So the pump can have the effect of anti-sands.

  4. Random geometric graph description of connectedness percolation in rod systems

    NASA Astrophysics Data System (ADS)

    Chatterjee, Avik P.; Grimaldi, Claudio

    2015-09-01

    The problem of continuum percolation in dispersions of rods is reformulated in terms of weighted random geometric graphs. Nodes (or sites or vertices) in the graph represent spatial locations occupied by the centers of the rods. The probability that an edge (or link) connects any randomly selected pair of nodes depends upon the rod volume fraction as well as the distribution over their sizes and shapes, and also upon quantities that characterize their state of dispersion (such as the orientational distribution function). We employ the observation that contributions from closed loops of connected rods are negligible in the limit of large aspect ratios to obtain percolation thresholds that are fully equivalent to those calculated within the second-virial approximation of the connectedness Ornstein-Zernike equation. Our formulation can account for effects due to interactions between the rods, and many-body features can be partially addressed by suitable choices for the edge probabilities.

  5. Substitute safety rods: Physics design and NTG calibration

    SciTech Connect

    Baumann, N.P.

    1991-07-01

    Under certain assumed accident conditions, an SRS reactor may loose most of its bulk moderator while maintaining flow to fuel assemblies. If this occurs immediately after operation at power, components normally dependent on convective heat transfer to the moderator will heat up with the possibility of melting that component. One component at risk is the safety rod. Tests have shown that the current cadmium safety rod, which contains aluminum as well as cadmium, can fail at temperatures only slightly in excess of 500 deg C. Computations indicate that such temperatures can be reached with operating powers well below the 50% power limit now imposed by other accident scenarios. Safety rod melting would thus establish a new lower operating limit. A substitute safety rod that could tolerate much higher temperatures would eliminate this limit. This memorandum details the physics characteristics of a suitable replacement rod. 7 refs.

  6. A Characterization of the Radiation from a Rod-Pinch

    NASA Astrophysics Data System (ADS)

    Swanekamp, S. B.; Allen, R. J.; Hinshelwood, D. D.; Mosher, D.; Schumer, J. W.; Young, F. C.

    2001-10-01

    The rod pinch diode is being developed as an intense, x-ray source for high-resolution flash radiography. Recent experiments on the Asterix pulsed-power generator at the CEG in France have demonstrated rod-pinch operation with 2-4 MV endpoint voltages and have demonstrated doses of = 5-23 rads-Si at 1 meter with a 1-mm diameter spot size. A series of = simulations with the Integrated Tiger Series (ITS) electron/photon transport code = were performed to characterize the radiation from a rod-pinch. The electron-energy and incident-angle distributions on the tungsten rod = were input to ITS from MAGIC PIC predictions. These simulations give = information about the angular dependence of the radiation from the rod-pinch and the axial extent of the radiation source. The results from these simulations will be compared with radiation measurements from Asterix.

  7. Entropical Colloidal Interaction in Rod-like Molecules Solution

    NASA Astrophysics Data System (ADS)

    Hohlfeld, Evan B.; Lin, Keng-Hui; Zeri, Ana Carolina; Crocker, John C.; Yodh, Arjun G.

    2001-03-01

    We report direct measurements of the functional form of the depletion interaction between two colloidal spheres in a rod-like molecule suspension the line-scanned optical tweezer. The rod like moleculses are bacteriaphage fd with length (L) 880 nm and diameter(D) 6.5 nm and TMV with L 300 nm and D 200 nm. We probed different ratios of sphere radius R and rod length L and compared with theoretical models of Yaman^. The experimental data agrees with the model with slight discrepancy due to the flexibility of rod molecules. At high salt concentration, we also observed the steric repulsion due rod molecule stuck on the spheres. We gratefully acknowledge support from the NSF (DMR-9623441) and MRSEC (DMR-9632598). K. Yaman, C. Jeppesen and C.M. Marques, Europhys. Lett., 42, 221 (1998).

  8. Cadmium control/safety rod disposal at the Savannah River Site

    SciTech Connect

    McInnis, S.H.

    1995-05-01

    Four heavy-water-moderated reactors at the Savannah River Site will undergo the removal of 862 activated cadmium control/safety rods. Although these reactors are 40 years old, they offer 4 basic advantages for decommissioning: the equipment is still in some sort of operable state; the reactor is blow the floor in a large process room, allowing access; Control/safety rods can be handled remotely by existing equipment; a radiologically shielded removal path exists. Drawbacks include the following: age of reactors; improvements in technology have caused incompatibility problems; more strigent standards; compliance with environmental regulations. This article details how the removal was carried out and the current status of the project, keeping in mind the above considerations.

  9. Behaviour of the rod network in the tiger salamander retina mediated by membrane properties of individual rods

    PubMed Central

    Attwell, David; Wilson, Martin

    1980-01-01

    1. The spread of electrical signals between rods in the salamander retina was examined by passing current into one rod and recording the voltage responses in nearby rods. Rod network behaviour, measured in this way, was simulated from data on rod membrane properties gathered in voltage-clamp experiments on single isolated rods. 2. The network voltage responses to square current pulses became smaller, more transient, and had a longer time-to-peak, for rods further away from the site of current injection. Depolarizing currents produced smaller responses than hyperpolarizing currents of the same magnitude. 3. Neighbouring rods and cones were coupled less strongly than neighbouring rods. 4. The response of the rod network to current injection was unaffected by 2 mm-aspartate-, which eliminates transmission from receptors to horizontal cells. 5. The input resistance of single isolated rods, measured at the resting potential, varied between 100 and 680 MΩ. The lower values were probably due to damage by the micro-electrodes. Electrical coupling was found to be very strong between the rod inner and outer segments. 6. A strong `instantaneous' outward rectification seen in isolated rods at potentials positive to -35 mV was reduced, but not abolished, by 15 mm-TEA. 7. In normal solution, isolated rods exhibited a voltage- and time-dependent current, IA, whose kinetics were approximated by a single first-order gating variable, and whose activation curve spanned the range between -40 and -80 mV. The time constant for the current varied with voltage and was 60-200 msec between -140 and -40 mV. 8. A reversal potential for IA could not be found between -140 and -40 mV in normal solution, and the fully activated current, ĪA, was approximately voltage-independent, with a magnitude of ∼ 0.1 nA over this potential range. 9. By several criteria, IA behaved as a single inward current activated by hyperpolarization. Pharmacological studies suggest, however, that it is the sum of at

  10. Mutating three residues in the bovine rod cyclic nucleotide-activated channel can switch a nucleotide from inactive to active.

    PubMed Central

    Scott, S P; Cummings, J; Joe, J C; Tanaka, J C

    2000-01-01

    Cyclic nucleotide-gated (CNG) channels, which were initially studied in retina and olfactory neurons, are activated by cytoplasmic cGMP or cAMP. Detailed comparisons of nucleotide-activated currents using nucleotide analogs and mutagenesis revealed channel-specific residues in the nucleotide-binding domain that regulate the binding and channel-activation properties. Of particular interest are N(1)-oxide cAMP, which does not activate bovine rod channels, and Rp-cGMPS, which activates bovine rod, but not catfish, olfactory channels. Previously, we showed that four residues coordinate the purine interactions in the binding domain and that three of these residues vary in the alpha subunits of the bovine rod, catfish, and rat olfactory channels. Here we show that both N(1)-oxide cAMP and Rp-cGMPS activate rat olfactory channels. A mutant of the bovine rod alpha subunit, substituted with residues from the rat olfactory channel at the three variable positions, was weakly activated by N(1)-oxide cAMP, and a catfish olfactory-like bovine rod mutant lost activation by Rp-cGMPS. These experiments underscore the functional importance of purine contacts with three residues in the cyclic nucleotide-binding domain. Molecular models of nucleotide analogs in the binding domains, constructed with AMMP, showed differences in the purine contacts among the channels that might account for activation differences. PMID:10777730

  11. Successful Gene Therapy in the RPGRIP1-deficient Dog: a Large Model of Cone–Rod Dystrophy

    PubMed Central

    Lhériteau, Elsa; Petit, Lolita; Weber, Michel; Le Meur, Guylène; Deschamps, Jack-Yves; Libeau, Lyse; Mendes-Madeira, Alexandra; Guihal, Caroline; François, Achille; Guyon, Richard; Provost, Nathalie; Lemoine, Françoise; Papal, Samantha; El-Amraoui, Aziz; Colle, Marie-Anne; Moullier, Philippe; Rolling, Fabienne

    2014-01-01

    For the development of new therapies, proof-of-concept studies in large animal models that share clinical features with their human counterparts represent a pivotal step. For inherited retinal dystrophies primarily involving photoreceptor cells, the efficacy of gene therapy has been demonstrated in canine models of stationary cone dystrophies and progressive rod–cone dystrophies but not in large models of progressive cone–rod dystrophies, another important cause of blindness. To address the last issue, we evaluated gene therapy in the retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1)-deficient dog, a model exhibiting a severe cone–rod dystrophy similar to that seen in humans. Subretinal injection of AAV5 (n = 5) or AAV8 (n = 2) encoding the canine Rpgrip1 improved photoreceptor survival in transduced areas of treated retinas. Cone function was significantly and stably rescued in all treated eyes (18–72% of those recorded in normal eyes) up to 24 months postinjection. Rod function was also preserved (22–29% of baseline function) in four of the five treated dogs up to 24 months postinjection. No detectable rod function remained in untreated contralateral eyes. More importantly, treatment preserved bright- and dim-light vision. Efficacy of gene therapy in this large animal model of cone–rod dystrophy provides great promise for human treatment. PMID:24091916

  12. Fretting wear behaviors of a dual-cooled nuclear fuel rod under a simulated rod vibration

    SciTech Connect

    Lee, Young-Ho; Kim, Hyung-Kyu; Kang, Heung-Seok; Yoon, Kyung-Ho; Kim, Jae-Yong; Lee, Kang-Hee

    2012-06-06

    Recently, a dual-cooled fuel (i.e., annular fuel) that is compatible with current operating PWR plants has been proposed in order to realize both a considerable amount of power uprating and an increase of safety margins. As the design concept should be compatible with current operating PWR plants, however, it shows a narrow gap between the fuel rods when compared with current solid nuclear fuel arrays and needs to modify the spacer grid shapes and their positions. In this study, fretting wear tests have been performed to evaluate the wear resistance of a dual-cooled fuel by using a proposed spring and dimple of spacer grids that have a cantilever type and hemispherical shape, respectively. As a result, the wear volume of the spring specimen gradually increases as the contact condition is changed from a certain gap, just contact to positive force. However, in the dimple specimen, just contact condition shows a large wear volume. In addition, a circular rod motion at upper region of contact surface is gradually increased and its diametric size depends on the wear depth increase. Based on the test results, the fretting wear resistance of the proposed spring and dimple is analyzed by comparing the wear measurement results and rod motion in detail.

  13. Age-related deterioration of rod vision in mice.

    PubMed

    Kolesnikov, Alexander V; Fan, Jie; Crouch, Rosalie K; Kefalov, Vladimir J

    2010-08-18

    Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically, photoreceptors. According to one hypothesis, the age-related deterioration in rod function is due to the limited availability of 11-cis-retinal for rod pigment formation. To determine how aging affects rod photoreceptors and to test the retinoid-deficiency hypothesis, we compared the morphological and functional properties of rods of adult and aged B6D2F1/J mice. We found that the number of rods and the length of their outer segments were significantly reduced in 2.5-year-old mice compared with 4-month-old animals. Aging also resulted in a twofold reduction in the total level of opsin in the retina. Behavioral tests revealed that scotopic visual acuity and contrast sensitivity were decreased by twofold in aged mice, and rod ERG recordings demonstrated reduced amplitudes of both a- and b-waves. Sensitivity of aged rods determined from single-cell recordings was also decreased by 1.5-fold, corresponding to not more than 1% free opsin in these photoreceptors, and kinetic parameters of dim flash response were not altered. Notably, the rate of rod dark adaptation was unaffected by age. Thus, our results argue against age-related deficiency of 11-cis-retinal in the B6D2F1/J mouse rod visual cycle. Surprisingly, the level of cellular dark noise was increased in aged rods, providing an alternative mechanism for their desensitization.

  14. Coolant mixing in LMFBR rod bundles and outlet plenum mixing transients. Progress report

    SciTech Connect

    Todreas, N.E.; Golay, M.W.; Wold, L.

    1981-02-01

    Four tasks are reported on: bundle geometry (wrapped and bare rods), subchannel geometry (bare rods), LMFBR outlet plenum flow mixing, and theoretical determination of local temperature fields in LMFBR fuel rod bundles. (DLC)

  15. Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa.

    PubMed

    Yang, Huan; Fu, Yingmei; Liu, Xinying; Shahi, Pawan K; Mavlyutov, Timur A; Li, Jun; Yao, Annie; Guo, Steven Z-W; Pattnaik, Bikash R; Guo, Lian-Wang

    2017-09-19

    Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease yet with no effective treatment available. The sigma-1 receptor (S1R), a ligand-regulated chaperone, emerges as a potential retina-protective therapeutic target. In particular, pharmacological activation of S1R was recently shown to rescue cones in the rd10 mouse, a rod Pde6b mutant that recapitulates the RP pathology of autonomous rod degeneration followed by secondary death of cones. The mechanisms underlying the S1R protection for cones are not understood in detail. By rearing rd10/S1R(-/-) and rd10/S1R(+/+) mice in dim light to decelerate rapid rod/cone degeneration, we were able to compare their retinal biochemistry, histology and functions throughout postnatal 3-6 weeks (3 W-6 W). The receptor-interacting protein kinases (RIP1/RIP3) and their interaction (proximity ligation) dramatically up-regulated after 5 W in rd10/S1R(-/-) (versus rd10/S1R(+/+)) retinas, indicative of intensified necroptosis activation, which was accompanied by exacerbated loss of cones. Greater rod loss in rd10/S1R(-/-) versus rd10/S1R(+/+) retinas was evidenced by more cleaved Caspase3 (4 W) and lower rod electro-retinographic a-waves (4 W-6 W), concomitant with reduced LC3-II and CHOP (4 W-6 W), markers of autophagy and endoplasmic reticulum stress response, respectively. However, the opposite occurred at 3 W. This study reveals previously uncharacterized S1R-associated mechanisms during rd10 photoreceptor degeneration, including S1R's influences on necroptosis and autophagy as well as its biphasic role in rod degeneration upstream of cone death.

  16. Immunocytochemical Evidence that Monkey Rod Bipolar Cells Use GABA

    PubMed Central

    Lassová, Luisa; Fina, Marie; Sulaiman, Pyroja; Vard, Noga

    2010-01-01

    Certain bipolar cells in most species immunostain for GABA or its synthesizing enzyme, GAD. However it is unknown whether they actually release GABA, and if so, from which cellular compartment, and by what release mechanism. We investigated these questions in monkey retina where rod bipolar cells immunostain for GABA. We found that rod bipolar cells immunostain for one isoform of GAD, GAD65, in their somas, dendrites, and axon terminals. Near the fovea, the somatic stain of rod bipolar cells is weaker than that of horizontal cells, but at the periphery, it is stronger. Staining for the vesicular GABA transporter in monkey rod bipolar cells is negative. On the other hand, staining for the GABA transporter, GAT3, is positive in the soma and primary dendrites (but not in the axon terminals). Staining for GAT3 is also positive in horizontal cells. Double staining of rod bipolar cells and the alpha subunit of the GABAA receptor, reveals scarce GABAA puncta that appose rod bipolar dendrites. We conclude that monkey rod bipolar cells use GABA, and discuss the possibility that they tonically release GABA from their dendrites using a reverse action of GAT3. PMID:20384812

  17. Distant Harrington rod migration 35 years after implantation.

    PubMed

    Lark, Robert K; Caputo, Adam M; Brown, Christopher R; Michael, Keith W; Thacker, Julie K; Richardson, William J

    2013-10-01

    Harrington rods have been successfully implanted in thousands of patients for the correction of scoliotic deformity since the 1950s. An exceedingly rare complication of Harrington rod placement is loosening with resultant migration. The authors present a 50-year-old woman who had a single Harrington rod placed when she was 15 years old. Thirty-five years later, she presented with acute sensory changes in her lower extremities. Imaging revealed rod failure and migration of the hardware distally, resulting in penetration of the wall of the rectum. Due to the unique anatomical position of the migrated hardware, sigmoidoscopy was used to directly visualize and remove the rod. The patient ultimately made a full recovery. Rod migration is an exceedingly rare complication that has been described only a few times since the introduction of Harrington rods over 60 years ago. The case herein is particularly unique given the extensive period of time that passed before migration (35 years) and the use of sigmoidoscopy for hardware removal.

  18. Diffusion of spheres in crowded suspensions of rods

    NASA Astrophysics Data System (ADS)

    Kang, Kyongok; Gapinski, J.; Lettinga, M. P.; Buitenhuis, J.; Meier, G.; Ratajczyk, M.; Dhont, Jan K. G.; Patkowski, A.

    2005-01-01

    Translational tracer diffusion of spherical macromolecules in crowded suspensions of rodlike colloids is investigated. Experiments are done using several kinds of spherical tracers in fd-virus suspensions. A wide range of size ratios L/2a of the length L of the rods and the diameter 2a of the tracer sphere is covered by combining several experimental methods: fluorescence correlation spectroscopy for small tracer spheres, dynamic light scattering for intermediate sized spheres, and video microscopy for large spheres. Fluorescence correlation spectroscopy is shown to measure long-time diffusion only for relatively small tracer spheres. Scaling of diffusion coefficients with a/ξ, predicted for static networks, is not found for our dynamical network of rods (with ξ the mesh size of the network). Self-diffusion of tracer spheres in the dynamical network of freely suspended rods is thus fundamentally different as compared to cross-linked networks. A theory is developed for the rod-concentration dependence of the translational diffusion coefficient at low rod concentrations for freely suspended rods. The proposed theory is based on a variational solution of the appropriate Smoluchowski equation without hydrodynamic interactions. The theory can, in principle, be further developed to describe diffusion through dynamical networks at higher rod concentrations with the inclusion of hydrodynamic interactions. Quantitative agreement with the experiments is found for large tracer spheres, and qualitative agreement for smaller spheres. This is probably due to the increasing importance of hydrodynamic interactions as compared to direct interactions as the size of the tracer sphere decreases.

  19. Dynamics of entangled rod-coil block copolymers

    NASA Astrophysics Data System (ADS)

    Wang, Muzhou; Timachova, Ksenia; Alexander-Katz, Alfredo; Likhtman, Alexei E.; Olsen, Bradley D.

    2014-03-01

    Polymer science is exploring advanced materials which combine functional domains such as proteins and semiconducting polymers with traditional flexible polymers onto the same molecule. While many studies have focused on equilibrium structure-property relationships, little is known about how the conformational restrictions of rigid domains affect dynamical phenomena such as mechanical properties, processing pathways, and self-assembly kinetics. We have recently introduced a reptation theory for entangled rod-coil block copolymers as a model for this wider class of functional polymeric materials. The theory hypothesizes that the motion of rod-coils is slowed relative to rod and coil homopolymers because of a mismatch between the curvature of the rod and coil entanglement tubes. This effect leads to activated reptation and arm retraction as two relaxation mechanisms that govern the short and long rod regimes, respectively. These results were verified by tracer diffusion measurements using molecular dynamics simulation and forced Rayleigh scattering in both the rod-coil diblock and coil-rod-coil triblock configurations. The tracer diffusion results were then compared to experimental self-diffusion measurements which require a consideration of the motion of the surrounding chains.

  20. Anisotropy in CdSe quantum rods

    SciTech Connect

    Li, Liang-shi

    2003-01-01

    The size-dependent optical and electronic properties of semiconductor nanocrystals have drawn much attention in the past decade, and have been very well understood for spherical ones. The advent of the synthetic methods to make rod-like CdSe nanocrystals with wurtzite structure has offered us a new opportunity to study their properties as functions of their shape. This dissertation includes three main parts: synthesis of CdSe nanorods with tightly controlled widths and lengths, their optical and dielectric properties, and their large-scale assembly, all of which are either directly or indirectly caused by the uniaxial crystallographic structure of wurtzite CdSe. The hexagonal wurtzite structure is believed to be the primary reason for the growth of CdSe nanorods. It represents itself in the kinetic stabilization of the rod-like particles over the spherical ones in the presence of phosphonic acids. By varying the composition of the surfactant mixture used for synthesis we have achieved tight control of the widths and lengths of the nanorods. The synthesis of monodisperse CdSe nanorods enables us to systematically study their size-dependent properties. For example, room temperature single particle fluorescence spectroscopy has shown that nanorods emit linearly polarized photoluminescence. Theoretical calculations have shown that it is due to the crossing between the two highest occupied electronic levels with increasing aspect ratio. We also measured the permanent electric dipole moment of the nanorods with transient electric birefringence technique. Experimental results on nanorods with different sizes show that the dipole moment is linear to the particle volume, indicating that it originates from the non-centrosymmetric hexagonal lattice. The elongation of the nanocrystals also results in the anisotropic inter-particle interaction. One of the consequences is the formation of liquid crystalline phases when the nanorods are dispersed in solvent to a high enough

  1. Coolant mixing in LMFBR rod bundles and outlet plenum mixing transients. Progress report, September 1, 1980-November 30, 1980

    SciTech Connect

    Todreas, N.E.; Golay, M.W.; Wolf, L.

    1981-02-01

    Four tasks are reported: bundle geometry (wrapped and bare rods), subchannel geometry (bare rods), subchannel geometry (bare rods), LMFBR outlet plenum flow mixing, and theoretical determination of local temperature fields in LMFBR fuel rod bundles. (DLC)

  2. Preventing Instrumentation Failure in Three-Column Spinal Osteotomy: Biomechanical Analysis of Rod Configuration.

    PubMed

    Jager, Zachary S; İnceoğlu, Serkan; Palmer, Daniel; Akpolat, Yusuf T; Cheng, Wayne K

    2016-01-01

    Biomechanical analysis. To show the role of additional rods and long-term fatigue strength to prevent the instrumentation failure on three-column osteotomies. Three-column osteotomy such as pedicle subtraction osteotomy (PSO) and vertebral column resections are surgical correction options for fixed spinal deformity. Posterior fixation for the PSO involves pedicle screw-and rod-based instrumentation, with the rods being contoured to accommodate the accentuated lordosis. Pseudarthrosis and instrumentation failure are known complications of PSO. Unilateral pedicle screw and rod constructs were mounted in ultra-high-molecular-weight polyethylene blocks using a vertebrectomy model with the rods contoured to simulate posterior fixation of a PSO. Each construct was cycled under a 200 N load at 5 Hz in simulated flexion and extension to rod failure. Three configurations (n = 5) of titanium alloy rods were tested: single rod (control), double rod, and bridging rod. Outcomes were total cycles to failure and location of rod failure. Double-rod and bridging-rod constructs had a significantly higher number of cycles to failure compared with the single-rod construct (p < .05). Single-rod constructs failed at or near the rod bend apex, whereas the majority of double-rod and bridging-rod constructs failed at the screw-rod or rod-connector junction. Double-rod and bridging-rod constructs are more resistant to fatigue failure compared with single-rod constructs in PSO instrumentation and could be considered to mitigate the risk of instrumentation failure. Copyright © 2016 Scoliosis Research Society. Published by Elsevier Inc. All rights reserved.

  3. Cleaning and excavating tool for control rod canopy seals

    SciTech Connect

    Kucera, R.A.

    1991-12-24

    This patent describes a device for servicing a weld site about the periphery of a control rod drive mechanism. It comprises a housing adapted to be rotated about the periphery of the control rod drive mechanism; a carriage reciprocably received within the housing; first movement means for reciprocating the carriage in a first direction; a tool attachment reciprocably received within the carriage; and second movement means for reciprocating the tool in a second direction; wherein the tool attachment is positioned relative to the control rod drive mechanism by the first and second movement means.

  4. System for fuel rod removal from a reactor module

    DOEpatents

    Matchett, Richard L.; Roof, David R.; Kikta, Thomas J.; Wilczynski, Rosemarie; Nilsen, Roy J.; Bacvinskas, William S.; Fodor, George

    1990-01-01

    A robotic system for remote underwater withdrawal of the fuel rods from fuel modules of a light water breeder reactor includes a collet/grapple assembly for gripping and removing fuel rods in each module, which is positioned by use of a winch and a radial support means attached to a vertical support tube which is mounted over the fuel module. A programmable logic controller in conjunction with a microcomputer, provides control for the accurate positioning and pulling force of the rod grapple assembly. Closed circuit television cameras are provided which aid in operator interface with the robotic system.

  5. System for fuel rod removal from a reactor module

    DOEpatents

    Matchett, R.L.; Fodor, G.; Kikta, T.J.; Bacvinsicas, W.S.; Roof, D.R.; Nilsen, R.J.; Wilczynski, R.

    1988-07-28

    A robotic system for remote underwater withdrawal of the fuel rods from fuel modules of a light water breeder reactor includes a collet/grapple assembly for gripping and removing fuel rods in each module, which is positioned by use of a winch and a radial support means attached to a vertical support tube which is mounted over the fuel module. A programmable logic controller in conjunction with a microcomputer, provides control for the accurate positioning and pulling force of the rod grapple assembly. Closed circuit television cameras are provided which aid in operator interface with the robotic system. 7 figs.

  6. In vivo imaging of the human rod photoreceptor mosaic

    PubMed Central

    Doble, Nathan; Choi, Stacey S.; Codona, Johanan L.; Christou, Julian; Enoch, Jay M.; Williams, David R.

    2011-01-01

    Although single cone receptors have been imaged in the living human eye, there has been no observation of rods in vivo. Using an adaptive optics (AO) ophthalmoscope and post processing, evidence of rod mosaic was observed at 5° and 10° eccentricities in the horizontal, temporal retina. For 4 normal human subjects, small structures were observed in between the larger cones, and were observed repeatedly at the same locations on different days and with varying wavelengths. Image analysis gave spacings that agree well with rod measurements from histological data. PMID:21209677

  7. COAXIAL CONTROL ROD DRIVE MECHANISM FOR NEUTRONIC REACTORS

    DOEpatents

    Fox, R.J.; Oakes, L.C.

    1959-04-14

    A drive mechanism is presented for the control rod or a nuclear reactor. In this device the control rod is coupled to a drive shaft which extends coaxially through the rotor of an electric motor for relative rotation with respect thereto. A gear reduction mehanism is coupled between the rotor and the drive shaft to convert the rotary motion of the motor into linear motion of the shaft with a comparatively great reduction in speed, thereby providing relatively glow linear movement of the shaft and control rod for control purposes.

  8. 26. A typical outer rod room, or rack room, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. A typical outer rod room, or rack room, showing the racks for the nine horizontal control rods (HCRs) that would be inserted or withdrawn from the pile to control the rate of reaction. In this case, it is the 105-F Reactor in February 1945. The view is looking away from the pile, which is out of the picture on the left. Several of the cooling water hose reels for the rods can be seen at the end of the racks near the wall. D-8323 - B Reactor, Richland, Benton County, WA

  9. Salamander rods and cones contain distinct transducin alpha subunits.

    PubMed

    Ryan, J C; Znoiko, S; Xu, L; Crouch, R K; Ma, J X

    2000-01-01

    The mammalian retina is known to contain two distinct transducins that interact with their respective rod and cone pigments. However, there are no reports of a nonmammalian species having two distinct transducins. In the present study, we report the cloning and cellular localization of two transducin a subunits (G alpha t) from the tiger salamander. Through degenerate polymerase chain reaction (PCR) and subsequent screening of a salamander retina cDNA library, we have identified two forms of G alpha t. When compared to existing sequences in GenBank, the cloned subunits showed high similarity to rod and cone transducins. The salamander G alpha t-1 has 91.2-93.7% amino acid sequence identity to mammalian rod G alpha t subunits and 79.7-80.9% to mammalian cone Gats. The salamander G alpha t-2 has 86.2-87.9% sequence identity to mammalian cone G alpha ts and 78.9-80.9% to mammalian rod G alpha ts at the amino acid level. The G alpha t-1 cDNA encodes 350 amino acids while the G alpha t-2 cDNA encodes 354 residues, which is typical for rod and cone G alpha ts, respectively, and we thus identified the G alpha t- 1 as rod and G alpha t-2 as cone G alpha t. Sequences identified as effector binding sites and GTPase activity regions are highly conserved between the two subunits. Genomic Southern blot analysis showed that rod and cone G alpha t subunits are both encoded by single-copy genes. Northern blot analysis identified retina-specific transcripts of 3.0 kb for rod G alpha t and 2.6 kb for cone G alpha t. Immunohistochemistry in the flat-mounted salamander retina demonstrated that rod G alpha t is localized to rods, predominantly in the outer segments; similarly, cone G alpha t is localized to cone outer segments. The results confirm that the two sequences encode rod and cone transducins and demonstrate that this lower vertebrate contains two distinct transducins that are localized specifically to rod and cone photoreceptors.

  10. Lateral suppression of mesopic rod and cone flicker detection

    PubMed Central

    Cao, Dingcai; Lu, Yolanda H.

    2012-01-01

    This study investigated the mechanisms of flicker detection suppression by measuring mesopic rod and cone critical flicker frequencies (CFFs) at different center and surround illuminance levels. Stimuli were generated with a four-primary photostimulator that provided independent control of rod and cone excitations. The results showed that dim surrounds ≤0.2 Td suppressed cone-mediated CFFs at ≥20 Td but not rod-mediated CFFs. These results can be understood in terms of peak amplitudes of photoreceptor impulse response functions under different stimulation conditions. PMID:22330377

  11. Rod gripper, changer, and storage system

    NASA Technical Reports Server (NTRS)

    Benson, Mark; Demi, Todd; Mcneill, Robert; Waldo, Keith; Afghan, Alex; Oliver, Jim

    1989-01-01

    A rod changer and storage design is presented for the lunar deep drill apparatus to be used in conjunction with the Skitter walking platform. The design must take into account all of the lunar environment and working conditions. Some of these are: (1) the moon has one sixth the gravity of earth; (2) temperature gradients can range from about -170 to 265 C; (3) because of the high transportation costs, the design must be as light as possible; and (4) the process must be remotely operated (from earth or satellite) and must be automated. Because of Skitter's multiple degree of freedom movement, the design will utilize Skitter's movement to locate an implement and transport it from the rack to the drill string. The implement will be gripped by a thumb and two finger device, identified through an electronic sensing device on the thumb, and transported from the rack to the footplate and back from the footplate to the rack. The major designs discussed in this report have been broken down into three major areas: (1) gripper design (linear transport mechanism); (2) indexing system; and (3) rack design.

  12. Studies on phosphoinositide metabolism in retinal rod outer segments

    SciTech Connect

    Gehm, B.D.

    1988-01-01

    The present work was undertaken to determine whether isolated mammalian photoreceptors (bovine rod outer segments, ROS) were capable of synthesizing and hydrolyzing phosphoinositides, and if so, how synthesis and hydrolysis might be regulated. Synthesis of phosphoinositides was demonstrated by the incorporation of radioactively labeled precursors. ROS incubated with ({gamma}{sup 32}P)ATP produced labeled phosphatidic acid (PA), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP{sub 2}). When Mn{sup 2+}, CTP and inositol were added, labeled phosphatidylinositol (PI) was also produced. ({sup 3}H)Inositol was incorporated into PI, PIP and PIP{sub 2}, although prolonged incubation was required for detectable incorporation into PIP{sub 2}. Incorporation of ({sup 3}H)inositol was dependent on CTP, indicating that labeling proceeded via synthesis, not base exchange. Incubation with ({alpha}-{sup 32}P)CTP produced labeled CDP-diacylglycerol, an intermediate in PI synthesis. Incorporation of labeled precursors was stimulated by Mg{sup 2+}, Mn{sup 2+} and spermine, but unaffected by light. Phosphoinositide hydrolysis was measured using exogenous {sup 3}H-labeled substrates. PI, PIP, and PIP{sub 2} were all hydrolyzed but most attention was devoted to PIP{sub 2}. Crude enzyme preparations contained an endogenous inhibitor whose effects were Ca{sup 2+}-dependently relieved by calmodulin antagonists. This inhibitor does not appear to be calmodulin but may be a novel Ca{sup 2+}-binding regulatory protein. No evidence for regulation of PLC activity by light or G-proteins was obtained. The effects on PLC activity of Mg{sup 2+}, Mn{sup 2+}, spermine, pH and detergents were also characterized.

  13. End-of-life nondestructive examination of Light Water Breeder Reactor fuel rods (LWBR Development Program)

    SciTech Connect

    Gorscak, D.A.; Campbell, W.R.; Clayton, J.C.

    1987-10-01

    In-bundle and out-of-bundle (single rod) nondestructive examinations of Light Water Breeder Reactor fuel rods were performed. In-bundle examinations included visual examination and measurement of rod bow, rod-to-rod gaps, and rod removal forces. Out-of-bundle examinations included rod visuals and measurement of fuel rod length, diameter and ovality, cladding oxide and crud thickness, support grid induced cladding wear mark depth and volume, and fuel rod free hanging bow. The out-of-bundle examination also included ultrasonic inspection for cladding defects, neutron radiography for pellet integrity and plenum gap measurements, and gamma scans for instack axial gap screening and binary fuel stack length measurements. The measurements confirmed design predictions of fuel rod performance and provided evidence of excellent fuel rod performance for operation of Light Water Breeder Reactor to 29,047 effective full power hours (EFPH).

  14. Large-eddy simulation, fuel rod vibration and grid-to-rod fretting in pressurized water reactors

    NASA Astrophysics Data System (ADS)

    Christon, Mark A.; Lu, Roger; Bakosi, Jozsef; Nadiga, Balasubramanya T.; Karoutas, Zeses; Berndt, Markus

    2016-10-01

    Grid-to-rod fretting (GTRF) in pressurized water reactors is a flow-induced vibration phenomenon that results in wear and fretting of the cladding material on fuel rods. GTRF is responsible for over 70% of the fuel failures in pressurized water reactors in the United States. Predicting the GTRF wear and concomitant interval between failures is important because of the large costs associated with reactor shutdown and replacement of fuel rod assemblies. The GTRF-induced wear process involves turbulent flow, mechanical vibration, tribology, and time-varying irradiated material properties in complex fuel assembly geometries. This paper presents a new approach for predicting GTRF induced fuel rod wear that uses high-resolution implicit large-eddy simulation to drive nonlinear transient dynamics computations. The GTRF fluid-structure problem is separated into the simulation of the turbulent flow field in the complex-geometry fuel-rod bundles using implicit large-eddy simulation, the calculation of statistics of the resulting fluctuating structural forces, and the nonlinear transient dynamics analysis of the fuel rod. Ultimately, the methods developed here, can be used, in conjunction with operational management, to improve reactor core designs in which fuel rod failures are minimized or potentially eliminated. Robustness of the behavior of both the structural forces computed from the turbulent flow simulations and the results from the transient dynamics analyses highlight the progress made towards achieving a predictive simulation capability for the GTRF problem.

  15. Force-extension curves for broken-rod macromolecules: Dramatic effects of different probing methods for two and three rods

    SciTech Connect

    Alexeev, A. V.; Maltseva, D. V.; Ivanov, V. A.; Klushin, L. I.; Skvortsov, A. M.

    2015-04-28

    We study force-extension curves of a single semiflexible chain consisting of several rigid rods connected by flexible spacers. The atomic force microscopy and laser optical or magnetic tweezers apparatus stretching these rod-coil macromolecules are discussed. In addition, the stretching by external isotropic force is analyzed. The main attention is focused on computer simulation and analytical results. We demonstrate that the force-extension curves for rod-coil chains composed of two or three rods of equal length differ not only quantitatively but also qualitatively in different probe methods. These curves have an anomalous shape for a chain of two rods. End-to-end distributions of rod-coil chains are calculated by Monte Carlo method and compared with analytical equations. The influence of the spacer’s length on the force-extension curves in different probe methods is analyzed. The results can be useful for interpreting experiments on the stretching of rod-coil block-copolymers.

  16. Large-eddy simulation, fuel rod vibration and grid-to-rod fretting in pressurized water reactors

    SciTech Connect

    Christon, Mark A.; Lu, Roger; Bakosi, Jozsef; Nadiga, Balasubramanya T.; Karoutas, Zeses; Berndt, Markus

    2016-10-01

    Grid-to-rod fretting (GTRF) in pressurized water reactors is a flow-induced vibration phenomenon that results in wear and fretting of the cladding material on fuel rods. GTRF is responsible for over 70% of the fuel failures in pressurized water reactors in the United States. Predicting the GTRF wear and concomitant interval between failures is important because of the large costs associated with reactor shutdown and replacement of fuel rod assemblies. The GTRF-induced wear process involves turbulent flow, mechanical vibration, tribology, and time-varying irradiated material properties in complex fuel assembly geometries. This paper presents a new approach for predicting GTRF induced fuel rod wear that uses high-resolution implicit large-eddy simulation to drive nonlinear transient dynamics computations. The GTRF fluid–structure problem is separated into the simulation of the turbulent flow field in the complex-geometry fuel-rod bundles using implicit large-eddy simulation, the calculation of statistics of the resulting fluctuating structural forces, and the nonlinear transient dynamics analysis of the fuel rod. Ultimately, the methods developed here, can be used, in conjunction with operational management, to improve reactor core designs in which fuel rod failures are minimized or potentially eliminated. Furthermore, robustness of the behavior of both the structural forces computed from the turbulent flow simulations and the results from the transient dynamics analyses highlight the progress made towards achieving a predictive simulation capability for the GTRF problem.

  17. Large-eddy simulation, fuel rod vibration and grid-to-rod fretting in pressurized water reactors

    DOE PAGES

    Christon, Mark A.; Lu, Roger; Bakosi, Jozsef; ...

    2016-10-01

    Grid-to-rod fretting (GTRF) in pressurized water reactors is a flow-induced vibration phenomenon that results in wear and fretting of the cladding material on fuel rods. GTRF is responsible for over 70% of the fuel failures in pressurized water reactors in the United States. Predicting the GTRF wear and concomitant interval between failures is important because of the large costs associated with reactor shutdown and replacement of fuel rod assemblies. The GTRF-induced wear process involves turbulent flow, mechanical vibration, tribology, and time-varying irradiated material properties in complex fuel assembly geometries. This paper presents a new approach for predicting GTRF induced fuelmore » rod wear that uses high-resolution implicit large-eddy simulation to drive nonlinear transient dynamics computations. The GTRF fluid–structure problem is separated into the simulation of the turbulent flow field in the complex-geometry fuel-rod bundles using implicit large-eddy simulation, the calculation of statistics of the resulting fluctuating structural forces, and the nonlinear transient dynamics analysis of the fuel rod. Ultimately, the methods developed here, can be used, in conjunction with operational management, to improve reactor core designs in which fuel rod failures are minimized or potentially eliminated. Furthermore, robustness of the behavior of both the structural forces computed from the turbulent flow simulations and the results from the transient dynamics analyses highlight the progress made towards achieving a predictive simulation capability for the GTRF problem.« less

  18. Large-eddy simulation, fuel rod vibration and grid-to-rod fretting in pressurized water reactors

    SciTech Connect

    Christon, Mark A.; Lu, Roger; Bakosi, Jozsef; Nadiga, Balasubramanya T.; Karoutas, Zeses; Berndt, Markus

    2016-10-01

    Grid-to-rod fretting (GTRF) in pressurized water reactors is a flow-induced vibration phenomenon that results in wear and fretting of the cladding material on fuel rods. GTRF is responsible for over 70% of the fuel failures in pressurized water reactors in the United States. Predicting the GTRF wear and concomitant interval between failures is important because of the large costs associated with reactor shutdown and replacement of fuel rod assemblies. The GTRF-induced wear process involves turbulent flow, mechanical vibration, tribology, and time-varying irradiated material properties in complex fuel assembly geometries. This paper presents a new approach for predicting GTRF induced fuel rod wear that uses high-resolution implicit large-eddy simulation to drive nonlinear transient dynamics computations. The GTRF fluid–structure problem is separated into the simulation of the turbulent flow field in the complex-geometry fuel-rod bundles using implicit large-eddy simulation, the calculation of statistics of the resulting fluctuating structural forces, and the nonlinear transient dynamics analysis of the fuel rod. Ultimately, the methods developed here, can be used, in conjunction with operational management, to improve reactor core designs in which fuel rod failures are minimized or potentially eliminated. Furthermore, robustness of the behavior of both the structural forces computed from the turbulent flow simulations and the results from the transient dynamics analyses highlight the progress made towards achieving a predictive simulation capability for the GTRF problem.

  19. Preparation of hydroxyapatite rod-like crystals by protein precursor method

    SciTech Connect

    Han Yingchao; Li Shipu . E-mail: zlhyc@yahoo.com.cn; Wang Xinyu; Jia Li; He Jianhua

    2007-06-05

    Hydroxyapatite (HAP) rod-like crystals were successfully prepared by thermolysis of bovine serum albumin (BSA)/calcium-phosphate (CaP) colloidal precursors. The precursors were obtained by precipitation method from Ca(H{sub 2}PO{sub 4}){sub 2} and Ca(OH){sub 2}, in which BSA was added as regulation additive and ultrasound irradiation was utilized as assistant technology. The properties of the precursors, such as size distribution, morphology, thermodynamic changes, were determined by DLS, SPM and TGA-DTA. The characterization results from DLS, SPM, TG-DTA, XRD and SEM indicated that BSA interacted with CaP particles and formed about 7-130 nm BSA/CaP hybrid colloidal particles between 2 and 4 g/L of BSA concentration. With the increasing of sintering temperature, BSA disintegrated and burned out, and rod-like HAP crystals formed at about 600 deg. C. With the increasing of BSA concentration, the phase composition of products did not change and the HAP crystals became more uniform and smaller. The ratio of length to width ranged from 7.6 to 12 at 4 g/L BSA concentration. This method provides for a controllable bottom-up fabrication of HAP rod-like crystals.

  20. Calcium-sensitive downregulation of the transduction chain in rod photoreceptors of the rat retina.

    PubMed

    Knopp, Andreas; Rüppel, Hartmann

    2006-08-01

    In vertebrate rod outer segments phototransduction is suggested to be modulated by intracellular Ca. We aimed at verifying this hypothesis by recording saturated photosignals in the rat retina after single and double flashes of light and determining the time t(c) to the beginning of the signal recovery. The time course of Ca(i) after a flash was calculated from a change of the spatial Ca(2+) concentration profile recorded in the space between the rods. After single flashes t(c) increased linearly with the logarithm of flash intensity, confirming the assumption that t(c) is determined by deactivation of a single species X* in the phototransduction cascade. The photoresponse was shortened up to 45% if the test flash was preceded by a conditioning preflash. The shortening depended on the reduction of Ca(i) induced by the preflash. The data suggest that the phototransduction gain determining the amount of activated X* is regulated by a Ca(i)-dependent mechanism in a short time period (<800 ms) after the test flash. Lowering of Ca(i) by a preflash reduced the gain up to 20% compared to its value in a dark-adapted rod. The relation between phototransduction gain and Ca(i) revealed a K(1/2) value close to the dark level of Ca(i).

  1. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice

    PubMed Central

    Howes, Kim A.; Pennesi, Mark E.; Sokal, Izabela; Church-Kopish, Jill; Schmidt, Ben; Margolis, David; Frederick, Jeanne M.; Rieke, Fred; Palczewski, Krzysztof; Wu, Samuel M.; Detwiler, Peter B.; Baehr, Wolfgang

    2002-01-01

    Visual transduction in retinal photoreceptors operates through a dynamic interplay of two second messengers, Ca2+ and cGMP. Ca2+ regulates the activity of guanylate cyclase (GC) and the synthesis of cGMP by acting on a GC-activating protein (GCAP). While this action is critical for rapid termination of the light response, the GCAP responsible has not been identified. To test if GCAP1, one of two GCAPs present in mouse rods, supports the generation of normal flash responses, transgenic mice were generated that express only GCAP1 under the control of the endogenous promoter. Paired flash responses revealed a correlation between the degree of recovery of the rod a-wave and expression levels of GCAP1. In single cell recordings, the majority of the rods generated flash responses that were indistinguishable from wild type. These results demonstrate that GCAP1 at near normal levels supports the generation of wild-type flash responses in the absence of GCAP2. PMID:11927539

  2. Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization

    PubMed Central

    Ursell, Tristan S.; Nguyen, Jeffrey; Monds, Russell D.; Colavin, Alexandre; Billings, Gabriel; Ouzounov, Nikolay; Gitai, Zemer; Shaevitz, Joshua W.; Huang, Kerwyn Casey

    2014-01-01

    Cells typically maintain characteristic shapes, but the mechanisms of self-organization for robust morphological maintenance remain unclear in most systems. Precise regulation of rod-like shape in Escherichia coli cells requires the MreB actin-like cytoskeleton, but the mechanism by which MreB maintains rod-like shape is unknown. Here, we use time-lapse and 3D imaging coupled with computational analysis to map the growth, geometry, and cytoskeletal organization of single bacterial cells at subcellular resolution. Our results demonstrate that feedback between cell geometry and MreB localization maintains rod-like cell shape by targeting cell wall growth to regions of negative cell wall curvature. Pulse-chase labeling indicates that growth is heterogeneous and correlates spatially and temporally with MreB localization, whereas MreB inhibition results in more homogeneous growth, including growth in polar regions previously thought to be inert. Biophysical simulations establish that curvature feedback on the localization of cell wall growth is an effective mechanism for cell straightening and suggest that surface deformations caused by cell wall insertion could direct circumferential motion of MreB. Our work shows that MreB orchestrates persistent, heterogeneous growth at the subcellular scale, enabling robust, uniform growth at the cellular scale without requiring global organization. PMID:24550515

  3. Genetic analysis of revertants isolated from the rod-fragile fliF mutant of Salmonella

    PubMed Central

    Komatsu, Hitomi; Hayashi, Fumio; Sasa, Masahiro; Shikata, Koji; Yamaguchi, Shigeru; Namba, Keiichi; Oosawa, Kenji

    2016-01-01

    FliF is the protein comprising the MS-ring of the bacterial flagellar basal body, which is the base for the assembly of flagellar axial structures. From a fliF mutant that easily releases the rod-hook-filament in viscous environments, more than 400 revertants that recovered their swarming ability in viscous conditions, were isolated. The second-site mutations were determined for approximately 70% of them. There were three regions where the mutations were localized: two in Region I, 112 in Region II, and 71 in Region III including the true reversion. In Region I, second-site mutations were found in FlgC and FlgF of the proximal rod, suggesting that they affect the interaction between the MS-ring and the rod. In Region II, there were 69 and 42 mutations in MotA and MotB, respectively, suggesting that the second-site mutations in MotA and MotB may decrease the rotational speed of the flagellar motor to reduce the probability of releasing the rod under this condition. One exception is a mutation in FlhC that caused a down regulation of the flagellar proteins production but it may directly affect transcription or translation of motA and motB. In Region III, there were 44, 24, and 3 mutations in FliG, FliM, and FliF, respectively. There were no second-site mutations identified in FliN although it is involved in torque generation as a component of the C-ring. Many of the mutations were involved in the motor rotation, and it is suggested that such reduced speeds result in stabilizing the filament attachment to the motor. PMID:27924254

  4. Inhibition of Matrix Metalloproteinase 9 Enhances Rod Survival in the S334ter-line3 Retinitis Pigmentosa Model

    PubMed Central

    Shin, Jung-A; Kim, Hwa Sun; Vargas, Andrew; Yu, Wan-Qing; Eom, Yun Sung; Craft, Cheryl Mae; Lee, Eun-Jin

    2016-01-01

    Retinitis Pigmentosa (RP) is one of the most common forms of inherited visual loss with the initial degeneration of rod photoreceptors, followed by a progressive cone photoreceptor deterioration. Coinciding with this visual loss, the extracellular matrix (ECM) is reorganized, which alters matrix metalloproteinase (MMP) activity levels. A potential pathological role of MMPs, MMP-9 in particular, involves an excitotoxicity-mediated physiological response. In the current study, we examine the MMP-9 and MMP-2 expression levels in the rhodopsin S334ter-line3 RP rat model and investigate the impact of treatment with SB-3CT, a specific MMP-9 and MMP-2 inhibitor, on rod cell survival was tested. Retinal MMP-9 and MMP-2 expression levels were quantified by immunoblot analysis from S334ter-line3 rats compared to controls. Gelatinolytic activities of MMP-9 and MMP-2 by zymography were examined. The geometry of rod death was further evaluated using Voronoi analysis. Our results revealed that MMP-9 was elevated while MMP-2 was relatively unchanged when S334ter-line 3 retinas were compared to controls. With SB-3CT treatment, we observed gelatinolytic activity of both MMPs was decreased and diminished clustering associated with rod death, in addition to a robust preservation of rod photoreceptors. These results demonstrate that up-regulation of MMP-9 in retinas of S334ter-line3 are associated with rod death. The application of SB-3CT dramatically interferes with mechanisms leading to apoptosis in an MMP-9-dependent manner. Future studies will determine the feasibility of using SB-3CT as a potential therapeutic strategy to slow progression of vision loss in genetic inherited forms of human RP. PMID:27893855

  5. 14. DETAIL VIEW OF ESCAPE TRAINING TANK, SHOWING HOLDDOWN RODS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. DETAIL VIEW OF ESCAPE TRAINING TANK, SHOWING HOLD-DOWN RODS, LOOKING SOUTH - U.S. Naval Submarine Base, New London Submarine Escape Training Tank, Albacore & Darter Roads, Groton, New London County, CT

  6. 28. VIEW OF OCTAGONAL SPREAD FOOTING AND HOLDDOWN RODS 1929, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. VIEW OF OCTAGONAL SPREAD FOOTING AND HOLD-DOWN RODS 1929, SUBMARINE ESCAPE TRAINING TANK - U.S. Naval Submarine Base, New London Submarine Escape Training Tank, Albacore & Darter Roads, Groton, New London County, CT

  7. 13. View of disassembled steam engine showing cylinder, piston rod, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. View of disassembled steam engine showing cylinder, piston rod, parallel motion links and steam chest. - Hacienda Azucarera La Esperanza, Steam Engine & Mill, 2.65 Mi. N of PR Rt. 2 Bridge over Manati River, Manati, Manati Municipio, PR

  8. 39. Detail view of No. 2 Furnace iron runner; rod ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. Detail view of No. 2 Furnace iron runner; rod or poker at right was used to unplug iron notch. - Sloss-Sheffield Steel & Iron, First Avenue North Viaduct at Thirty-second Street, Birmingham, Jefferson County, AL

  9. 7. DETAIL VIEW UNDER BRIDGE OF CORRUGATED STEEL, BEAMS, RODS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. DETAIL VIEW UNDER BRIDGE OF CORRUGATED STEEL, BEAMS, RODS, AND ABUTMENT - Price River Bridge, Spanning Price River, 760 North Street in Carbonville, 1 mile northwest of Price, Carbonville, Carbon County, UT

  10. 31. DETAIL OF DIAGONAL REINFORCING RODS TYPICAL OF FLOORS IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. DETAIL OF DIAGONAL REINFORCING RODS TYPICAL OF FLOORS IN CLASSROOMS AT NORTH PORTIONS OF EAST AND WEST WINGS - Frederika Bremer Intermediate School, 1214 Lowry Avenue North, Minneapolis, Hennepin County, MN

  11. Control of rod shedding in the frog retina.

    PubMed

    Basinger, S F; Hollyfield, J G

    1980-01-01

    In all vertebrate species examined thus far, rod outer segment shedding follows a cyclic pattern in which the outer segment tips are shed shortly after the onset of light. Work in the rat retina suggests that rod shedding may follow a circadian rhythm which is controlled by one or more circadian oscillators. Our results in the frog retina are significantly different in that: rod shedding can be driven by the onset of light or other environmental cues; shedding does not persist in constant darkness; shedding is unaffected in frogs with chronic unilateral or bilateral optic nerve section; and shedding will rapidly phase shift to the time of light onset on a wide variety of diurnal cycles. Thus, rod shedding in the frog retina does not appear to be a classical circadian rhythm.

  12. Remotely operated gripper provides vertical control rod movement

    NASA Technical Reports Server (NTRS)

    Hutter, E.; Koch, L. J.

    1968-01-01

    Remote actuation of a gripper shaft affects vertical engagement between a drive shaft and control rod. A secondary function of the gripper is to provide remote indication of positive completion of the gripping or ungripping operation.

  13. Self-monitoring Composite Rods for Sustainable Construction

    NASA Astrophysics Data System (ADS)

    Gonilho-Pereira, Cristiana; Zdraveva, Emilija; Fangueiro, Raul; Lanceros-Mendez, S.; Jalali, Said; de Araújo, Mário

    This paper presents the development and properties assessment of braided reinforced composite rods (BCR) able to both reinforce and monitor the stress state of concrete infrastructures. The research study aims at understanding the tensile behaviour and self-monitoring ability of composite rods reinforced by a textile structure - braided structure with core reinforcement - for civil engineering applications, namely for concrete internal reinforcement, as a steel substitute, in order to improve structures safety and sustainability. Seven types of braided composite rods have been produced using an author patented technique based on a modified conventional braiding machine. The tensile properties of the braided reinforced composite rods were evaluated in order to identify the type(s) of fibre(s) to be used as core reinforcement. BCR have been tested under bending while the variation of the electrical resistance was simultaneously monitored.

  14. Development of visual and tactile rod orientation in children.

    PubMed

    Meerwaldt, J D; Schmitz, P I

    1988-09-15

    Two groups of neurologically normal children (total number 64), aged from 4 to 13 years, were examined with the rod orientation test. In the second group, the line orientation test and finger tapping were also studied in addition to the rod orientation test. On the rod orientation test, the mean error rates decreased with age in both groups, and from the age of 10 the children performed as well as normal adults. In the period (ages 4-7 years) in which the greatest change in performance on the visual part of the rod orientation test had taken place (63%), a much smaller change occurred in the tapping frequency (23%). Thus the development of motor skills does not seem to be directly related to the development of spatial perception. The line orientation test did not show any developmental profile.

  15. VIEW OF CABLES AND TAPES ASSOCIATED WITH ADRIVE CONTROL ROD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CABLES AND TAPES ASSOCIATED WITH A-DRIVE CONTROL ROD SYSTEM, AT LEVEL +15’, DIRECTLY ABOVE PDP CONTROL ROOM, LOOKING NORTH - Physics Assembly Laboratory, Area A/M, Savannah River Site, Aiken, Aiken County, SC

  16. Inertial Range Scaling in Rotations of Long Rods in Turbulence

    NASA Astrophysics Data System (ADS)

    Voth, Greg; Parsa, Shima

    2013-11-01

    We measure the rotational statistics of neutrally buoyant rods with lengths 2 . 8 < l / η < 72 . 9 in turbulence. For particles with length in the inertial range, we derive a scaling relationship for the mean square rotation rate, <ṗiṗi > ~l - 4 / 3 and show that measurements approach this scaling. Deviations from the proposed scaling are explained as the effect of dissipation range scales. The correlation time of the Lagrangian autocorrelation of rod rotation rate scales as the turn over time of eddies of the size of the rod. Measuring rotational dynamics of single long rods provides a new way to access the dynamics of turbulence at fixed spatial scale in a frame advected with the flow. Supported by NSF grant DMR-1208990.

  17. Scaled long rod penetration experiments: Tungsten against rolled homogeneous armour

    NASA Astrophysics Data System (ADS)

    Proud, William; Cross, Daniel

    2012-03-01

    Scaled, reverse ballistic, long-rod experiments were performed at an impact velocity of ~700 m s-1. The targets were tungsten alloy rods and the projectiles either 3 or 6 mm thick rolled homogeneous armour (RHA) plates. The plate was inclined at 60° to the direction of travel and the interaction was recorded using high-speed photography, strain gauges and laser velocimetry. The pitch of the rod was varied in steps of 3° over a total range of 15°. In this range the rod deformation changed dramatically the bending process moved from a flexing of the tip away from the plate, to a marked motion into the surface. Cross comparison of the diagnostic outputs reveals the time windows for these process and also the varying sensitivity of the measurement system to that process. Post-impact recovery was also performed.

  18. End of truss showing upper chord, bottom chord rod, compression ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    End of truss showing upper chord, bottom chord rod, compression strut and connector - Central of Georgia Railway, Passenger Station & Train Shed, Corner of Louisville (Railroad) Road & West Broad Street, Savannah, Chatham County, GA

  19. Scaled Long Rod Perforation Experiments Using Multiple Diagnostics

    NASA Astrophysics Data System (ADS)

    Cross, Daniel; Proud, William

    2011-06-01

    A series of angled small-scale reverse ballistic long rod experiments were conducted using mild steel rods (6 mm dia., 90 mm long) against both 3 mm and 6 mm rolled homogeneous armour (RHA) plates at 30°. The impact velocity was varied from 450-780 m s-1 and the response of the system monitored by laser velocimetry, strain gauges and high-speed photography. This provided insight into the flexing of the rod during impact, the acceleration of the rear of the rod and the global penetration process. This experimental series involved ricochet, near-ricochet and full perforation, and so allows the sensitivity of the differing diagnostic outputs for these processes to be compared.

  20. DETAIL VIEW OF LOWER CHORD CONNECTIONS AND SAG RODS, SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF LOWER CHORD CONNECTIONS AND SAG RODS, SOUTH TRUSS, EAST END, LOOKING NORTHWEST - Henszey's Wrought-Iron Arch Bridge, Spanning Ontelaunee Creek at Kings Road, Wanamakers, Lehigh County, PA

  1. 25. DETAIL OF TIE ROD REINFORCING BELOW WESTERNMOST MOVABLE STAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. DETAIL OF TIE ROD REINFORCING BELOW WESTERNMOST MOVABLE STAGE SECTION, LOWER LEVEL OF STAGE, LOOKING SOUTH. TAKEN FROM A POINT JUST SOUTH OF RAM IN IL-1007-24. - Auditorium Building, 430 South Michigan Avenue, Chicago, Cook County, IL

  2. Efficiency of Hysteresis Rods in Small Spacecraft Attitude Stabilization

    PubMed Central

    Farrahi, Assal; Sanz-Andrés, Ángel

    2013-01-01

    A semiempirical method for predicting the damping efficiency of hysteresis rods on-board small satellites is presented. It is based on the evaluation of dissipating energy variation of different ferromagnetic materials for two different rod shapes: thin film and circular cross-section rods, as a function of their elongation. Based on this formulation, an optimum design considering the size of hysteresis rods, their cross section shape, and layout has been proposed. Finally, the formulation developed was applied to the case of four existing small satellites, whose corresponding in-flight data are published. A good agreement between the estimated rotational speed decay time and the in-flight data has been observed. PMID:24501579

  3. Process-based tolerance assessment of connecting rod machining process

    NASA Astrophysics Data System (ADS)

    Sharma, G. V. S. S.; Rao, P. Srinivasa; Surendra Babu, B.

    2016-01-01

    Process tolerancing based on the process capability studies is the optimistic and pragmatic approach of determining the manufacturing process tolerances. On adopting the define-measure-analyze-improve-control approach, the process potential capability index ( C p) and the process performance capability index ( C pk) values of identified process characteristics of connecting rod machining process are achieved to be greater than the industry benchmark of 1.33, i.e., four sigma level. The tolerance chain diagram methodology is applied to the connecting rod in order to verify the manufacturing process tolerances at various operations of the connecting rod manufacturing process. This paper bridges the gap between the existing dimensional tolerances obtained via tolerance charting and process capability studies of the connecting rod component. Finally, the process tolerancing comparison has been done by adopting a tolerance capability expert software.

  4. Rod shop, roof and truss detail showing older pink roof ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Rod shop, roof and truss detail showing older pink roof truss, newer pratt truss, and longitudinal, truss for overhead traveling crane - Chicago, Burlington & Quincy Railroad, Roundhouse & Shops, Broadway & Spring Streets, Aurora, Kane County, IL

  5. Tritium Producing Burnable Absorber Rod and Its Inherent Safety Features

    SciTech Connect

    Reid, Bruce D.; Lanning, Donald D.

    2000-06-24

    Description of the Tritium-producing burnable absorber rods (TPBARs) used in the U.S. Department of Energy's Commercial Light Water Reactor (CLWR) Project and a discussion of their inherent safety features.

  6. 9. Detail of gears and connection rod to sluice gate ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Detail of gears and connection rod to sluice gate - Mississippi River 9-Foot Channel, Lock & Dam No. 1, In Mississippi River at Mississippi Boulevard, below Ford Parkway Bridge, Saint Paul, Ramsey County, MN

  7. Steam Engine for Shop, lineshaft, detail of crosshead, rod and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Steam Engine for Shop, lineshaft, detail of crosshead, rod and flywheel - East Broad Top Railroad & Coal Company, Machine Shop, State Route 994, West of U.S. Route 522, Rockhill Furnace, Huntingdon County, PA

  8. Double-clad nuclear-fuel safety rod

    DOEpatents

    McCarthy, W.H.; Atcheson, D.B.

    1981-12-30

    A device for shutting down a nuclear reactor during an undercooling or overpower event, whether or not the reactor's scram system operates properly. This is accomplished by double-clad fuel safety rods positioned at various locations throughout the reactor core, wherein melting of a secondary internal cladding of the rod allows the fuel column therein to shift from the reactor core to place the reactor in a subcritical condition.

  9. Bead-rod-spring models in random flows

    NASA Astrophysics Data System (ADS)

    Plan, Emmanuel Lance Christopher Medillo, VI; Ali, Aamir; Vincenzi, Dario

    2016-08-01

    Bead-rod-spring models are the foundation of the kinetic theory of polymer solutions. We derive the diffusion equation for the probability density function of the configuration of a general bead-rod-spring model in short-correlated Gaussian random flows. Under isotropic conditions, we solve this equation analytically for the elastic rhombus model introduced by Curtiss, Bird, and Hassager [Adv. Chem. Phys. 35, 31 (1976)].

  10. Actin dynamics and cofilin-actin rods in Alzheimer disease

    PubMed Central

    Bamburg, James R.; Bernstein, Barbara W.

    2017-01-01

    Cytoskeletal abnormalities and synaptic loss, typical of both familial and sporadic Alzheimer disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress, and energetic stress, each of which may be initiated or enhanced by proinflammatory cytokines or amyloid-β (Aβ) peptides. Extracellular Aβ-containing plaques and intracellular phospho-tau-containing neurofibrillary tangles are postmortem pathologies required to confirm AD and have been the focus of most studies. However, AD brain, but not normal brain, also have increased levels of cytoplasmic rod-shaped bundles of filaments composed of ADF/cofilin-actin in a 1:1 complex (rods). Cofilin, the major ADF/cofilin isoform in mammalian neurons, severs actin filaments at low cofilin/actin ratios and stabilizes filaments at high cofilin/actin ratios. It binds cooperatively to ADP-actin subunits in F-actin. Cofilin is activated by dephosphorylation and may be oxidized in stressed neurons to form disulfide-linked dimers, required for bundling cofilin-actin filaments into stable rods. Rods form within neurites causing synaptic dysfunction by sequestering cofilin, disrupting normal actin dynamics, blocking transport, and exacerbating mitochondrial membrane potential loss. Aβ and proinflammatory cytokines induce rods through a cellular prion protein-dependent activation of NADPH oxidase and production of reactive oxygen species. Here we review recent advances in our understanding of cofilin biochemistry, rod formation, and the development of cognitive deficits. We will then discuss rod formation as a molecular pathway for synapse loss that may be common between all three prominent current AD hypotheses, thus making rods an attractive therapeutic target. PMID:26873625

  11. Silk fibroin rods for sustained delivery of breast cancer therapeutics.

    PubMed

    Yucel, Tuna; Lovett, Michael L; Giangregorio, Raffaella; Coonahan, Erin; Kaplan, David L

    2014-10-01

    A silk-protein based reservoir rod was developed for zero-order and long-term sustained drug delivery applications. Silk reservoir rod formulations were processed in three steps. First, a regenerated silk fibroin solution, rich in random-coil content was transformed into a tubular silk film with controllable dimensions, uniform film morphology and a structure rich in silk II, β-sheet content via "film-spinning." Second, the drug powder was loaded into swollen silk tubes followed by tube end clamping. Last, clamped silk tube ends were sealed completely via dip coating. Anastrozole, an FDA approved active ingredient for the treatment of breast cancer, was used as a model drug to investigate viability of the silk reservoir rod technology for sustained drug delivery. The in vitro and in vivo pharmacokinetic data (in a female Sprague-Dawley rat model) analyzed via liquid chromatography-tandem mass spectroscopy indicated zero-order release for 91 days. Both in vitro and in vivo anastrozole release rates could be controlled simply by varying silk rod dimensions. The swelling behavior of silk films and zero-order anastrozole release kinetics indicated practically immediate film hydration and formation of a linear anastrozole concentration gradient along the silk film thickness. The dependence of anastrozole release rate on the overall silk rod dimensions was in good agreement with an essentially diffusion-controlled sustained release from a reservoir cylindrical geometry. In vivo results highlighted a strong in vitro-in vivo pharmacokinetic correlation and a desirable biocompatibility profile of silk reservoir rods. During a 6-month implantation in rats, the apparent silk molecular weight values decreased gradually, while rod dry mass and β-sheet crystal content values remained essentially constant, providing a suitable timeframe for controlled, long-term sustained delivery applications. Overall, the silk reservoir rod may be a viable candidate for sustained delivery of

  12. Apparatus for injection casting metallic nuclear energy fuel rods

    DOEpatents

    Seidel, Bobby R.; Tracy, Donald B.; Griffiths, Vernon

    1991-01-01

    Molds for making metallic nuclear fuel rods are provided which present reduced risks to the environment by reducing radioactive waste. In one embodiment, the mold is consumable with the fuel rod, and in another embodiment, part of the mold can be re-used. Several molds can be arranged together in a cascaded manner, if desired, or several long cavities can be integrated in a monolithic multiple cavity re-usable mold.

  13. Final design review of boron carbide safety rod

    SciTech Connect

    Lutz, R.N.

    1991-09-24

    The object of this paper discusses the design review of the boron carbide safety rod for the Westinghouse Savannah River Company. This paper reviewed information presented by personnel of the Savannah River Laboratory (SRL) Equipment Engineering Section, SRL Materials Technology Section and Reactor Materials Engineering and Technology. From this report, views, opinions and recommendations were made on the safety rod from materials testing to production.

  14. Computer program for automatic generation of BWR control rod patterns

    SciTech Connect

    Taner, M.S.; Levine, S.H.; Hsia, M.Y. )

    1990-01-01

    A computer program named OCTOPUS has been developed to automatically determine a control rod pattern that approximates some desired target power distribution as closely as possible without violating any thermal safety or reactor criticality constraints. The program OCTOPUS performs a semi-optimization task based on the method of approximation programming (MAP) to develop control rod patterns. The SIMULATE-E code is used to determine the nucleonic characteristics of the reactor core state.

  15. BWR fuel rod performance evaluation program. Final report

    SciTech Connect

    Rowland, T.C.

    1986-05-01

    The joint EPRI/GE fuel performance program, RP510-1, involved thorough preirradiation characterization of fuel used in lead test assemblies, detailed surveillance of their operation, and interim site examinations of the assemblies during reactor outages. The program originally included four GE-5 lead test assemblies operating in the Peach Bottom-2 reactor. The program was later modified to include the pressurized fuel rod test assembly in the Peach Bottom-3 reactor (RP510-2). The program modification also included extending the operation of the Peach Bottom-2 and Peach Bottom-3 lead test assembly fuel beyond normal discharge exposures. Interim site examination results following the first four cycles of operation of the Peach Bottom-2 lead test assemblies up to 35 GWd/MT and the examination of the Peach Bottom-3 pressurized test assembly at 32 GWd/MT are presented in this report. Elements of the examinations included visual examination of the fuel bundles; individual fuel rod visual examinations, rod length measurements, ultrasonic and eddy current nondestructive testing, Zircaloy cladding oxide thickness measurements and fission gas measurements. Channel measurements were made on the PB-2 Lead Test Assemblies after each of the first three operating cycles. All of the bundles were found to be in good condition. Since the pressurized test assembly contained pressurized and nonpressurized fuel rods in symmetric positions, it was possible to make direct comparisons of the fission gas release from pairs of pressurized and nonpressurized fuel rods with identical power histories. With one exception, the release was less from the pressurized fuel rod of each pair. Fuel rod power histories were calculated using new physics methods for all of the fuel rods that were punctured for fission gas release measurements. 28 refs., 41 figs., 16 tabs.

  16. Final design review of boron carbide safety rod

    SciTech Connect

    Lutz, R.N.

    1991-09-24

    The object of this paper discusses the design review of the boron carbide safety rod for the Westinghouse Savannah River Company. This paper reviewed information presented by personnel of the Savannah River Laboratory (SRL) Equipment Engineering Section, SRL Materials Technology Section and Reactor Materials Engineering and Technology. From this report, views, opinions and recommendations were made on the safety rod from materials testing to production.

  17. Swimming in a suspension of rod-like molecules

    NASA Astrophysics Data System (ADS)

    Shi, Juan; Powers, Thomas

    2016-11-01

    In nature, it is common for microorganisms to swim in fluids with microstructure, such as mucus. Motivated by this fact, there have been many recent theoretical, computational, and experimental studies of idealized swimmers in a dilute solution of flexible polymers. Here we study this problem from a different point of view by considering swimmers in a dilute solution of rigid rod-like polymers. We study the prescribed swimming problem of Taylor's sheet in a dilute suspension of non-Brownian rods. Using a simple continuum constitutive law for the suspension that describes the stress in terms of velocity gradient and local rod orientation, we calculate swimming speed to second order in the amplitude of the wave. Due to stresses induced by the presence of the rods, the first-order flow field differs from that of the Newtonian case. We find that the swimming speed increases linearly with rod concentration: the presence of the rods always makes the swimmer go faster. We also consider the problem of a finite swimmer by studying a two-dimensional circular squirmer. The squirmer is defined as a circle with a prescribed tangential slip velocity that leads to propulsion. By varying the prescribed slip boundary condition, we study both pushers and pullers.

  18. Fission gas release restrictor for breached fuel rod

    DOEpatents

    Kadambi, N. Prasad; Tilbrook, Roger W.; Spencer, Daniel R.; Schwallie, Ambrose L.

    1986-01-01

    In the event of a breach in the cladding of a rod in an operating liquid metal fast breeder reactor, the rapid release of high-pressure gas from the fission gas plenum may result in a gas blanketing of the breached rod and rods adjacent thereto which impairs the heat transfer to the liquid metal coolant. In order to control the release rate of fission gas in the event of a breached rod, the substantial portion of the conventional fission gas plenum is formed as a gas bottle means which includes a gas pervious means in a small portion thereof. During normal reactor operation, as the fission gas pressure gradually increases, the gas pressure interiorly of and exteriorly of the gas bottle means equalizes. In the event of a breach in the cladding, the gas pervious means in the gas bottle means constitutes a sufficient restriction to the rapid flow of gas therethrough that under maximum design pressure differential conditions, the fission gas flow through the breach will not significantly reduce the heat transfer from the affected rod and adjacent rods to the liquid metal heat transfer fluid flowing therebetween.

  19. Evaluation of ceramic packed-rod regenerator matrices

    NASA Technical Reports Server (NTRS)

    Lawless, W. N.; Arenz, R. W.

    1981-01-01

    An extensive evaluation of a modified cryocooler with various regenerator matrices is reported. The matrices examined are 0.015 in. diam. Pb spheres and 0.008, 0.015, and 0.030 in. diam. rods of a 0.2% SnCl2 doped ceramic labelled LS-8A. Specific heat and thermal conductivity data on these rod materials are also reported. The chronic pulverization/dusting problem common to Pb spheres was investigated. During a 1000 hr life test with 0.0008 in. diam. rods there was no degradation of the refrigerator performance, and a subsequent examination of the rods themselves revealed no evidence of breakage or pulverization. The load temperature characteristics for the rod packed regenerators were inferior to that for the Pb spheres, the effect being to shift the Pb spheres load curve up in temperature. This temperature shift was 5.0, 7.4, and 11.6K for the 0.0008, 0.015, and 0.030 in. diam. rods, respectively.

  20. Distributed temperature sensing inside a 19-rod bundle

    DOE PAGES

    Lomperski, S.; Bremer, N.; Gerardi, C.

    2017-05-23

    The temperature field within a model of a sodium-cooled fast reactor fuel rod bundle was measured using Ø155 μm fiber optic distributed temperature sensors (DTS). The bundle consists of 19 electrically-heated rods Ø6.3 mm and 865 mm long. Working fluids were argon and air at atmospheric pressure and Reynolds numbers up to 300. A 20 m-long DTS was threaded through Ø1 mm capillaries wound around rods as wire-wraps. The sensor generated 173 measurements along each rod at 5 mm resolution for a total of 3300 data locations. A second DTS, 58 m long, was suspended between rods to provide 9300more » fluid temperature measurements at 20 mm resolution. Such data density makes it possible to construct 3D maps of the temperature field that are beyond the reach of traditional sensors such as thermocouples. This is illustrated through a series of steady-state and transient tests. As a result, the work demonstrates the feasibility of mapping temperature within the close confines of a rod bundle at resolutions suitable for validation of computational fluid dynamics codes.« less

  1. Diurnal control of rod function in the chicken.

    PubMed

    Schaeffel, F; Rohrer, B; Lemmer, T; Zrenner, E

    1991-06-01

    We studied rod function in the chicken by recording corneal electroretinograms (ERGs). The following experiments were performed to demonstrate rod function during daytime: (1) determining the dark-adaptation function; (2) measuring the spectral sensitivity by a a-b-wave amplitude criterion in response to monochromatic flickering light of different frequencies ranging from 6.5-40.8 Hz (duty cycle 1:1); (3) analyzing the response vs. log stimulus intensity (V-log I) function in order to reveal a possible two phase process; and (4) determining the spectral sensitivity function either in a non-dark adapted state or after dark adaptation of the animals for 1 and 24 h. None of these experiments demonstrated clear evidence of rod function during daytime. On the other hand, we found rods histologically by light- and electron microscopy. Therefore, we repeated our ERG recordings during the night (between midnight and 3:00 A.M.). Without previous dark adaptation, rod function could be seen immediately in the same experiments described above. The result shows that, in the chicken, rods are turned on endogenously during the night but are scarcely functional during the day.

  2. Experimental and computational studies of rod-deployment mechanisms

    SciTech Connect

    Schwalbe, L.A.; Wingate, C.A.; Stofleth, J.H.; Greene, R.W.

    1996-08-01

    We describe experimental measurements and hydrocode simulations of two tests in which long (L/D=12), steel rods were accelerated laterally with charges of Detasheet-C high explosive (HE). In each test configuration, 84 rods were initially aligned parallel to one another in an array of four concentric rings. The first test had a central core of HE that dispersed the rods isotropically. The second test had a narrow, 180 degree strip of HE on one side of the assembly that focused the rods directionally. Using radiographic data taken at several milliseconds after HE initiation, we measured the dynamic distributions of the rods, and their translational velocities and tumble rates. To compare with the data, we also modeled the experiments with our smooth particle hydrocode SPHINX. Within the context of our numerical model, the hydrocode results agree satisfactorily with the test data. We include in our discussion many of the inferences and insights that our results provide to the phenomenology and performance of multimode, rod-deployment mechanisms.

  3. Faced folded rods as nano-antenna for optical devices

    NASA Astrophysics Data System (ADS)

    Chung, Taerin; Choi, Jinyoung; Lim, Yongjun; Lee, Il-Min; Kim, Kyoung-Youm; Lee, Byoungho

    2010-11-01

    We propose faced folded rods (FFR) as nano-antenna for light emissions. This FFR structure, which is composed of two folded gold rods, shows two different field enhancement modes depending on the polarization direction of feeding light. Under the incidence of x-polarized light, double hot spots are observed at gaps due to capacitive coupling between rods. Meanwhile, when y-polarized light is applied to this geometry, a single hot spot is achieved at the center of the structure which is due to the superposition of half-wavelength dipole resonance occurring at each folded rod. Strong resonance of several vertices, which is predicted to be 100 of electric field enhancement factor in FFRs, can be achieved for sensitive bio-molecular detection. Thus, we can manipulate the number and position of desired hot spots by way of controlling the polarization state of light. Since we can obtain up to four different hot spot areas in nano-meter scale, multiplexed biosensing can be possible using FFRs as the nano-antenna. To understand the physical mechanism behind the pair type of folded rods, a single folded rod is first simulated as a basic elementary structure and compared with the pair structure. Then, this FFR structure is fabricated with an electron beam evaporator and the focused ion beam lithography. The scattered light intensity is captured by a CCD camera and compared with the simulation data.

  4. Fabrication of vertically aligned ferroelectric polyvinylidene fluoride mesoscale rod arrays

    DOE PAGES

    Kim, Dongjin; Hong, Seungbum; Hong, Jongin; ...

    2013-05-14

    Here, we have fabricated vertically aligned ferroelectric PVDF mesoscale rod arrays comprising and phases using a 200 nm diameter anodized aluminum oxide (AAO) as the porous template. We could synthesize the ferroelectric phase in mesoscale rod forms by combining the well-established recipe for crystallizing the phase using dimethyl sulfoxide (DMSO) at low temperature and template-guided infiltration processing for the rods using AAO. We also measured the dimensions of the PVDF rods by scanning electron microscopy and identified the polymorph phases by X-ray diffraction and Fourier transform infrared spectroscopy. The length of the rods varied from 3.82 m to 1.09 mmore » and the diameter from 232 nm to 287 nm when the volume ratio between DMSO and acetone changed from 5 : 5 to 10 : 0. We obtained well-defined piezoresponse hysteresis loops for all rods with remnant piezoresponse ranging from 2.12 pm/V to 5.04 pm/V and coercive voltage ranging from 2.29 V to 2.71 V using piezoresponse force microscopy. These results serve as a processing platform for flexible electronic devices that need high capacitance and piezoelectric functionalities such as flexible memory devices or body energy harvesting devices for intelligent systems. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3842-3848, 2013« less

  5. Some Aspects of Research on Mechanics of Thin Elastic Rod

    NASA Astrophysics Data System (ADS)

    Yanzhu, Liu; Yun, Xue

    2013-07-01

    Some aspects of research wok on the mechanics of thin elastic rod based on Kirchhoff-Cosserat's model were summarized. The analytical mechanics with arc-coordinate s and time t as double variables was established to formulate the motion of elastic rod. In stability analysis the difference and relationship between Lyapunov's stability and Euler's stability were discussed. The first approximate stability was determined by the characteristic equation with double eigenvalues in different domains, one of which can be determined by geometric conditions in static analysis. The Lyapunov's and Euler's stability conditions of the rod in space domain are the necessary conditions of Lyapunov's stability in time domain. As applications of the Kirchhoff's rod in molecular biology, the explanations of nucleosome structure and the chromosome coiling of DNA were given. Concerning the application in engineering the shape of a hanging rod under gravity and the coiling and stretching process of an extendable space mast were discussed. The motion of an axial moving beam with constant velocity and axial extensive force was discussed as an example of exact Cosserat's rod, the special case of small deformation is the Timoshenko's beam.

  6. Shell runs 14,500-ft sucker rod completion

    SciTech Connect

    Wilson, J.W.

    1982-12-01

    Discusses a well in Wyoming's Reno field which features a modified downhole pump, a custom-made polished rod, and a special electric motor. String design was augmented by Shell's RodCal computer program that calculates load, stress, torque, horsepower requirements, stroke length, strokes per minute, and rod length and number. The pump is a 1 1/4-in. RHBM (API Spec. 11AX-B12) with an 11/16-in. valve rod. The polished rod is 30-ft long with a 1 1/2 diam, with a shoulder at the bottom and a conventional end at the top. The steel tapered rod string is a binary construction, run in 25-ft sections. The length of the string presented problems on the surface. To avoid midstring shock loading, Shell used an ultrahigh slip motor which slows from 1,170 to approximately 800 rpm on the downstroke to allow the string time to synchronize before starting the upstroke. The 70 b/d rate is expected to increase as the Reno field is under waterflood.

  7. Fabrication of vertically aligned ferroelectric polyvinylidene fluoride mesoscale rod arrays

    SciTech Connect

    Kim, Dongjin; Hong, Seungbum; Hong, Jongin; Choi, Yoon-Young; Kim, Jiyoon; Park, Moonkyu; Sung, Tae-hyun; No, Kwangsoo

    2013-05-14

    Here, we have fabricated vertically aligned ferroelectric PVDF mesoscale rod arrays comprising and phases using a 200 nm diameter anodized aluminum oxide (AAO) as the porous template. We could synthesize the ferroelectric phase in mesoscale rod forms by combining the well-established recipe for crystallizing the phase using dimethyl sulfoxide (DMSO) at low temperature and template-guided infiltration processing for the rods using AAO. We also measured the dimensions of the PVDF rods by scanning electron microscopy and identified the polymorph phases by X-ray diffraction and Fourier transform infrared spectroscopy. The length of the rods varied from 3.82 m to 1.09 m and the diameter from 232 nm to 287 nm when the volume ratio between DMSO and acetone changed from 5 : 5 to 10 : 0. We obtained well-defined piezoresponse hysteresis loops for all rods with remnant piezoresponse ranging from 2.12 pm/V to 5.04 pm/V and coercive voltage ranging from 2.29 V to 2.71 V using piezoresponse force microscopy. These results serve as a processing platform for flexible electronic devices that need high capacitance and piezoelectric functionalities such as flexible memory devices or body energy harvesting devices for intelligent systems. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3842-3848, 2013

  8. Hydraulic testing of accelerator-production-of-tritium rod bundles

    SciTech Connect

    Spatz, T.L.; Siebe, D.A.

    1999-01-01

    Hydraulic tests have been performed on small pitch-to-diameter-ratio rod bundles using light water (1.7 < P/D < 1.17, and d = 3.175 mm). Flows cover the range from greater-than-nominal Reynolds numbers (fully turbulent) to low-speed laminar flows. Differential pressure measurements were made across the support plates holding the rod bundles, across the rod bundles, and across the entire assembly. Flow rates, temperatures, and gauge pressures also were measured. The data from these hydraulic tests have been compared to correlating literature for tightly pitched rod bundles. The prototypic geometry of these tests did not compare directly to any geometry found in the literature because of the variety of subchannels along the outer wall of the rod bundle. Under that constraint, there was excellent comparison of the rod-bundle friction factor with those factors given in the literature. The results show a large range of the Reynolds number over which the flow is in transition from laminar to turbulent (e.g., 580 < Re{sub Tr} < 13,000). Also presented is the comparison of the overall rung pressure drop to a solution based on hydraulic-resistance handbook calculations.

  9. Vibrational Power Flow Analysis of Rods and Beams

    NASA Technical Reports Server (NTRS)

    Wohlever, James Christopher; Bernhard, R. J.

    1988-01-01

    A new method to model vibrational power flow and predict the resulting energy density levels in uniform rods and beams is investigated. This method models the flow of vibrational power in a manner analogous to the flow of thermal power in a heat conduction problem. The classical displacement solutions for harmonically excited, hysteretically damped rods and beams are used to derive expressions for the vibrational power flow and energy density in the rod and beam. Under certain conditions, the power flow in these two structural elements will be shown to be proportional to the energy density gradient. Using the relationship between power flow and energy density, an energy balance on differential control volumes in the rod and beam leads to a Poisson's equation which models the energy density distribution in the rod and beam. Coupling the energy density and power flow solutions for rods and beams is also discussed. It is shown that the resonant behavior of finite structures complicates the coupling of solutions, especially when the excitations are single frequency inputs. Two coupling formulations are discussed, the first based on the receptance method, and the second on the travelling wave approach used in Statistical Energy Analysis. The receptance method is the more computationally intensive but is capable of analyzing single frequency excitation cases. The traveling wave approach gives a good approximation of the frequency average of energy density and power flow in coupled systems, and thus, is an efficient technique for use with broadband frequency excitation.

  10. 77 FR 3231 - Certain Stainless Steel Wire Rods From India: Continuation of Antidumping Duty Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... Stainless Steel Wire Rods From India: Continuation of Antidumping Duty Order AGENCY: Import Administration... antidumping duty order on certain stainless steel wire rods from India would likely lead to continuation or... reviews of the antidumping duty order on certain stainless steel wire rods (``wire rods'') from...

  11. 78 FR 76815 - Steel Threaded Rod From India: Preliminary Affirmative Countervailing Duty Determination and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... International Trade Administration Steel Threaded Rod From India: Preliminary Affirmative Countervailing Duty... subsidies are being provided to producers and exporters of steel threaded rod from India. The period of... Investigation The merchandise covered by this investigation is steel threaded rod. Steel threaded rod is certain...

  12. 78 FR 12718 - Certain Steel Threaded Rod From the People's Republic of China: Affirmative Final Determination...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... International Trade Administration Certain Steel Threaded Rod From the People's Republic of China: Affirmative... concerning the antidumping duty order on certain steel threaded rod (``steel threaded rod'') from the People.... No other party filed comments. \\1\\ See Certain Steel Threaded Rod From the People's Republic of...

  13. Linear motion device and method for inserting and withdrawing control rods

    DOEpatents

    Smith, Jay E.

    1984-01-01

    A linear motion device, more specifically a control rod drive mechanism (CRDM) for inserting and withdrawing control rods into a reactor core, is capable of independently and sequentially positioning two sets of control rods with a single motor stator and rotor. The CRDM disclosed can control more than one control rod lead screw without incurring a substantial increase in the size of the mechanism.

  14. AN INTRODUCTION TO THE CUISENAIRE RODS, AN APPROACH TO THE TEACHING OF ELEMENTARY MATHEMATICS.

    ERIC Educational Resources Information Center

    HULL, WILLIAM P.

    CUISENAIRE RODS ARE COLORED, RECTANGULAR PIECES OF WOOD ONE UNIT WIDE AND ANY NUMBER OF UNITS LONG. THE COLOR OF THE ROD DEPENDS UPON ITS LENGTH. RODS CAN BE USED IN KINDERGARTEN THROUGH HIGH SCHOOL, BUT ARE PARTICULARILY HELPFUL IN THE EARLY GRADES. THE RODS CAN BE USED TO TEACH CHILDREN SUCH CONCEPTS AS…

  15. Rod internal pressure quantification and distribution analysis using Frapcon

    SciTech Connect

    Bratton, Ryan N; Jessee, Matthew Anderson; Wieselquist, William A

    2015-09-01

    This report documents work performed supporting the Department of Energy (DOE) Office of Nuclear Energy (NE) Fuel Cycle Technologies Used Fuel Disposition Campaign (UFDC) under work breakdown structure element 1.02.08.10, ST Analysis. In particular, this report fulfills the M4 milestone M4FT- 15OR0810036, Quantify effects of power uncertainty on fuel assembly characteristics, within work package FT-15OR081003 ST Analysis-ORNL. This research was also supported by the Consortium for Advanced Simulation of Light Water Reactors (http://www.casl.gov), an Energy Innovation Hub (http://www.energy.gov/hubs) for Modeling and Simulation of Nuclear Reactors under U.S. Department of Energy Contract No. DE-AC05-00OR22725. The discharge rod internal pressure (RIP) and cladding hoop stress (CHS) distributions are quantified for Watts Bar Nuclear Unit 1 (WBN1) fuel rods by modeling core cycle design data, operation data (including modeling significant trips and downpowers), and as-built fuel enrichments and densities of each fuel rod in FRAPCON-3.5. A methodology is developed which tracks inter-cycle assembly movements and assembly batch fabrication information to build individual FRAPCON inputs for each evaluated WBN1 fuel rod. An alternate model for the amount of helium released from the zirconium diboride (ZrB2) integral fuel burnable absorber (IFBA) layer is derived and applied to FRAPCON output data to quantify the RIP and CHS for these types of fuel rods. SCALE/Polaris is used to quantify fuel rodspecific spectral quantities and the amount of gaseous fission products produced in the fuel for use in FRAPCON inputs. Fuel rods with ZrB2 IFBA layers (i.e., IFBA rods) are determined to have RIP predictions that are elevated when compared to fuel rod without IFBA layers (i.e., standard rods) despite the fact that IFBA rods often have reduced fill pressures and annular fuel pellets. The primary contributor to elevated RIP predictions at burnups less than and greater than 30 GWd

  16. Characterisation of the canine rod-cone dysplasia type one gene (rod photoreceptor cGMP phosphodiesterase beta subunit (PDEB)) - a model for human retinitis pigmentosa

    SciTech Connect

    Clements, P.J.M.; Gregory, C.Y.; Petersen-Jones, S.M.

    1994-09-01

    Rod-cone dysplasia type one (rod-1) is an early onset, autosomal recessive retinal dystrophy segregating in the Irish setter breed. It is a model for certain forms of human autosomal recessive retinitis pigmentosa (arRP) caused by mutations in the same gene, PDEB. We confirmed the codon 807 Trp to Stop mutation and were the first to show cosegregation of the mutant allele with disease in a pedigree. We believe that this currently represents the best animal model available for some aspects of arRP, since canine tissues are relatively easy to access compared to human and yet the canine eye is of comparable size, unlike that of the rd mouse. This facilitates therapeutic intervention particularly at the subretinal level. In order to more fully investigate this model we have been characterizing the PDEB gene in the normal dog. Using PCR we have partially mapped the intron/exon structure, demonstrating a very high degree of evolutionary conservation with the mouse and human genes. RT-PCR has been used to reveal expression in a variety of neural and non-neural tissues. A PCR product spanning exons 19 to 22 (which also contains the site for the rcd-1 mutation) is detected in retina but also in tissues such as visual cortex, cerebral cortex, cerebellum, lateral geniculate nucleus, adrenal gland, lung, kidney and ovary. All of these tissues gave a negative result with primers for rds/peripherin, a gene which is expressed in rods and cones. This raises interesting questions about the regulation of PDEB transcripts which is initially being investigated by Northern analysis. In addition, anchored PCR techniques have generated upstream genomic sequences and we are currently mapping the 5{prime} extent of the mRNA transcript in the retina. This will facilitate the analysis of potential upstream promoter elements involved in directing expression.

  17. Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.

    PubMed

    Dirisala, Anjaneyulu; Osada, Kensuke; Chen, Qixian; Tockary, Theofilus A; Machitani, Kaori; Osawa, Shigehito; Liu, Xueying; Ishii, Takehiko; Miyata, Kanjiro; Oba, Makoto; Uchida, Satoshi; Itaka, Keiji; Kataoka, Kazunori

    2014-07-01

    Poly(ethylene glycol) (PEG) modification onto a gene delivery carrier for systemic application results in a trade-off between prolonged blood circulation and promoted transfection because high PEG shielding is advantageous in prolonging blood retention, while it is disadvantageous with regard to obtaining efficient transfection owing to hampered cellular uptake. To tackle this challenging issue, the present investigation focused on the structure of polyplex micelles (PMs) obtained from PEG-poly(l-lysine) (PEG-PLys) block copolymers characterized as rod-shaped structures to seek the most appreciable formulation. Comprehensive investigations conducted with particular focus on stability, PEG crowdedness, and rod length, controlled by varying PLys segment length, clarified the effect of these structural features, with particular emphasis on rod length as a critical parameter in promoting cellular uptake. PMs with rod length regulated below the critical threshold length of 200 nm fully exploited the benefits of cross-linking and the cyclic RGD ligand, consequently, exhibiting remarkable transfection efficiency comparable with that of ExGen 500 and Lipofectamine(®) LTX with PLUS™ even though PMs were PEG shielded. The identified PMs exhibited significant antitumor efficacy in systemic treatment of pancreatic adenocarcinoma, whereas PMs with rod length above 200 nm exhibited negligible antitumor efficacy despite a superior blood circulation property, thereby highlighting the significance of controlling the rod length of PMs to promote gene transduction.

  18. Use of Supplemental Short Pre-Contoured Accessory Rods and Cobalt Chrome Alloy Posterior Rods Reduces Primary Rod Strain and Range of Motion Across the Pedicle Subtraction Osteotomy Level: An In Vitro Biomechanical Study.

    PubMed

    Hallager, Dennis Winge; Gehrchen, Martin; Dahl, Benny; Harris, Jonathan A; Gudipally, Manasa; Jenkins, Sean; Wu, Ai-Min; Bucklen, Brandon S

    2016-04-01

    In vitro cadaveric biomechanical study. To assess effects of 4-rod reconstruction, rod material, and anterior column support on motion and surface rod strain in a pedicle subtraction osteotomy model. Pedicle subtraction osteotomy (PSO) can correct significant sagittal deformity of the lumbar spine; however, revision rates are high. To reduce rod strain and the incidence of rod fracture, clinical use of multi-rod construction, cobalt chrome (CoCr) alloy rods, and interbody spacers adjacent to PSO has been proposed. Investigating both motion and rod strain is necessary to determine the biomechanical efficacy of these techniques. Five specimens (T12-S1) underwent PSO at L3 with pedicle screw stabilization at L1-S1. Pedicle subtraction was adjusted to achieve a final lordosis of 70°. Flexion-extension (FE), lateral bending, and axial rotation were applied. Linear strain gauges measured surface rod strain during FE on primary and accessory rods at PSO level. Testing evaluated (1) accessory rods (4-Rod) added at PSO level versus primary rods (2-Rod); (2) Ti versus CoCr rods; and (3) lateral interbody spacers (S) inserted adjacent to PSO. One-way and three-way analysis of variance was performed (P ≤ 0.05). All constructs significantly reduced FE and lateral bending motion relative to intact (P < 0.001). The main effect of accessory rods in reducing FE motion was significant (P = 0.021). Accessory and CoCr rods reduced relative surface strain on the primary rod, irrespective of construct (P < 0.001). CoCr 4-Rod + S provided the greatest reduction in strain (76% decrease; P = 0.003). Accessory and CoCr rods provided greatest reduction in motion and rod strain at PSO level. Interbody devices minimally affected motion-induced strain and might act primarily to maintain disc height. Clinicians must assess whether surface strain and motion reduction minimize the incidence of rod fracture. N/A.

  19. Biomechanical stability according to different configurations of screws and rods.

    PubMed

    Ha, Kee-Yong; Hwang, Sung-Chul; Whang, Tae-Hyuk

    2013-05-01

    Comparison of biomechanical strength according to 2 different configurations of screws and rods. To compare the biomechanical strength of different configurations of screws and rods composed of the same material and of the same size. Many complications related to instrumentation have been reported. The incidence of metallic failure would differ according to the materials and configurations of the assembly of the screws and rods used. However, to our knowledge, the biomechanical effects of implant assembly rods and screws with different configurations and different contours have not been reported. Biomechanical testing was conducted to compare top tightening (TT) screw-rod configuration with side tightening (ST) screw-rod configuration. All tests were conducted using a hydraulic all-purpose testing machine. All data were acquired at a rate of 10 Hz. Both screw systems used spinal rods of 6 mm diameter and were made of TiAl4V ELI material. Among 5 types of tests, 3 were conducted on the basis of American Society for Testing and Materials (ASTM) F 1798 to 97 and F1717-10. The other 2 tests were conducted for comparing the characteristics between TT and ST pedicle screws according to modified methods from ASTM F 1717-10 and ASTM F 1798-97. All results including axial gripping capacity and yield forces were obtained using the same methods on the basis of the mentioned ASTM standards. In the axial gripping capacity test, the mean axial gripping capacity of the TT screw-rod configuration was 3332 ± 118 N and that of ST was 2222 ± 147 N in straight rods (P = 0.019). In 15-degree contoured rods, TT was 2988 ± 199 N and ST was 2116 ± 423 N (P = 0.014). In 30-degree contoured rods, TT was 2227 ± 408 N and ST was 1814 ± 285 N (P = 0.009). In the pulling-out test, the pulling-out force of ST was 8695 ± 1616 N and that of TT was 6106 ± 195 N (P = 0.014). In the rod-pushing test, the failure force of ST was 4131 ± 205 N and that of TT was 5639 ± 105 N. In the

  20. A Multi-Stage Wear Model for Grid-to-Rod Fretting of Nuclear Fuel Rods

    SciTech Connect

    Blau, Peter Julian

    2014-01-01

    The wear of fuel rod cladding against the supporting structures in the cores of pressurized water nuclear reactors (PWRs) is an important and potentially costly tribological issue. Grid-to-rod fretting (GTRF), as it is known, involves not only time-varying contact conditions, but also elevated temperatures, flowing hot water, aqueous tribo-corrosion, and the embrittling effects of neutron fluences. The multi-stage, closed-form analytical model described in this paper relies on published out-of-reactor wear and corrosion data and a set of simplifying assumptions to portray the conversion of frictional work into wear depth. The cladding material of interest is a zirconium-based alloy called Zircaloy-4, and the grid support is made of a harder and more wear-resistant material. Focus is on the wear of the cladding. The model involves an incubation stage, a surface oxide wear stage, and a base alloy wear stage. The wear coefficient, which is a measure of the efficiency of conversion of frictional work into wear damage, can change to reflect the evolving metallurgical condition of the alloy. Wear coefficients for Zircaloy-4 and for a polyphase zirconia layer were back-calculated for a range of times required to wear to a critical depth. Inputs for the model, like the friction coefficient, are taken from the tribology literature in lieu of in-reactor tribological data. Concepts of classical fretting were used as a basis, but are modified to enable the model to accommodate the complexities of the PWR environment. Factors like grid spring relaxation, pre-oxidation of the cladding, multiple oxide phases, gap formation, impact, and hydrogen embrittlement are part of the problem definition but uncertainties in their relative roles limits the ability to validate the model. Sample calculations of wear depth versus time in the cladding illustrate how GTRF wear might occur in a discontinuous fashion during months-long reactor operating cycles. A means to account for grid/rod gaps

  1. Detection of single photons by toad and mouse rods.

    PubMed

    Reingruber, Jürgen; Pahlberg, Johan; Woodruff, Michael L; Sampath, Alapakkam P; Fain, Gordon L; Holcman, David

    2013-11-26

    Amphibian and mammalian rods can both detect single photons of light even though they differ greatly in physical dimensions, mammalian rods being much smaller in diameter than amphibian rods. To understand the changes in physiology and biochemistry required by such large differences in outer segment geometry, we developed a computational approach, taking into account the spatial organization of the outer segment divided into compartments, together with molecular dynamics simulations of the signaling cascade. We generated simulations of the single-photon response together with intrinsic background fluctuations in toad and mouse rods. Combining this computational approach with electrophysiological data from mouse rods, we determined key biochemical parameters. On average around one phosphodiesterase (PDE) molecule is spontaneously active per mouse compartment, similar to the value for toad, which is unexpected due to the much smaller diameter in mouse. A larger number of spontaneously active PDEs decreases dark noise, thereby improving detection of single photons; it also increases cGMP turnover, which accelerates the decay of the light response. These constraints explain the higher PDE density in mammalian compared with amphibian rods that compensates for the much smaller diameter of mammalian disks. We further find that the rate of cGMP hydrolysis by light-activated PDE is diffusion limited, which is not the case for spontaneously activated PDE. As a consequence, in the small outer segment of a mouse rod only a few activated PDEs are sufficient to generate a signal that overcomes noise, which permits a shorter lifetime of activated rhodopsin and greater temporal resolution.

  2. Rod/Coil Block Copolyimides for Ion-Conducting Membranes

    NASA Technical Reports Server (NTRS)

    Meador, Mary Ann B.; Kinder, James D.

    2003-01-01

    Rod/coil block copolyimides that exhibit high levels of ionic conduction can be made into diverse products, including dimensionally stable solid electrolyte membranes that function well over wide temperature ranges in fuel cells and in lithium-ion electrochemical cells. These rod/coil block copolyimides were invented to overcome the limitations of polymers now used to make such membranes. They could also be useful in other electrochemical and perhaps some optical applications, as described below. The membranes of amorphous polyethylene oxide (PEO) now used in lithium-ion cells have acceptably large ionic conductivities only at temperatures above 60 C, precluding use in what would otherwise be many potential applications at lower temperatures. PEO is difficult to process, and, except at the highest molecular weights it is not very dimensionally stable. It would be desirable to operate fuel cells at temperatures above 80 C to take advantage of better kinetics of redox reactions and to reduce contamination of catalysts. Unfortunately, proton-conduction performance of a typical perfluorosulfonic polymer membrane now used as a solid electrolyte in a fuel cell decreases with increasing temperature above 80 C because of loss of water from within the membrane. The loss of water has been attributed to the hydrophobic nature of the polymer backbone. In addition, perfluorosulfonic polymers are expensive and are not sufficiently stable for long-term use. Rod/coil block copolyimides are so named because each molecule of such a polymer comprises short polyimide rod segments alternating with flexible polyether coil segments (see figure). The rods and coils can be linear, branched, or mixtures of linear and branched. A unique feature of these polymers is that the rods and coils are highly incompatible, giving rise to a phase separation with a high degree of ordering that creates nanoscale channels in which ions can travel freely. The conduction of ions can occur in the coil phase

  3. Cyclic GMP diffusion coefficient in rod photoreceptor outer segments.

    PubMed

    Koutalos, Y; Nakatani, K; Yau, K W

    1995-01-01

    Cyclic GMP (cGMP) is the intracellular messenger that mediates phototransduction in retinal rods. As photoisomerizations of rhodopsin molecules are local events, the longitudinal diffusion of cGMP in the rod outer segment should be a contributing factor to the response of the cell to light. We have employed the truncated rod outer segment preparation from bullfrog (Rana catesbeiana) and tiger salamander (Ambystoma tigrinum) to measure the cGMP diffusion coefficient. In this preparation, the distal portion of a rod outer segment was drawn into a suction pipette for measuring membrane current, and the rest of the cell was then sheared off with a glass probe, allowing bath cGMP to diffuse into the outer segment and activate the cGMP-gated channels on the surface membrane. Addition and removal of bath cGMP were fast enough to produce effectively step changes in cGMP concentration at the open end of the outer segment. When cGMP hydrolysis is inhibited by isobutylmethylxanthine (IBMX), the equation for the diffusion of cGMP inside the truncated rod outer segment has a simple analytical solution, which we have used to analyze the rise and decay kinetics of the cGMP-elicited currents. From these measurements we have obtained a cGMP diffusion coefficient of approximately 70 x 10(-8) cm2 s-1 for bullfrog rods and approximately 60 x 10(-8) cm2 s-1 for tiger salamander rods. These values are six to seven times lower than the expected value in aqueous solution. The estimated diffusion coefficient is the same at high (20-1000 microM) and low (5-10 microM) concentrations of cGMP, suggesting no significant effect from buffering over these concentration ranges.

  4. Estimation of rod scale errors in geodetic leveling

    USGS Publications Warehouse

    Craymer, Michael R.; Vaníček, Petr; Castle, Robert O.

    1995-01-01

    Comparisons among repeated geodetic levelings have often been used for detecting and estimating residual rod scale errors in leveled heights. Individual rod-pair scale errors are estimated by a two-step procedure using a model based on either differences in heights, differences in section height differences, or differences in section tilts. It is shown that the estimated rod-pair scale errors derived from each model are identical only when the data are correctly weighted, and the mathematical correlations are accounted for in the model based on heights. Analyses based on simple regressions of changes in height versus height can easily lead to incorrect conclusions. We also show that the statistically estimated scale errors are not a simple function of height, height difference, or tilt. The models are valid only when terrain slope is constant over adjacent pairs of setups (i.e., smoothly varying terrain). In order to discriminate between rod scale errors and vertical displacements due to crustal motion, the individual rod-pairs should be used in more than one leveling, preferably in areas of contrasting tectonic activity. From an analysis of 37 separately calibrated rod-pairs used in 55 levelings in southern California, we found eight statistically significant coefficients that could be reasonably attributed to rod scale errors, only one of which was larger than the expected random error in the applied calibration-based scale correction. However, significant differences with other independent checks indicate that caution should be exercised before accepting these results as evidence of scale error. Further refinements of the technique are clearly needed if the results are to be routinely applied in practice.

  5. HIV, rods, and the muscles--a discussion about HIV-associated nemaline rod myopathy.

    PubMed

    Madonia, Phillip; Wilson, Jon; Bican, Orhan; Willis, Megan; Bass, Pat

    2012-01-01

    This case reports a 21-year-old, homosexual African-American male who presented to our facility with a two-week history of progressive proximal muscle weakness. Quadriceps muscle biopsy showed a diagnosis of Nemaline Rod Myopathy, the presenting disease of his HIV infection. A review of the literature shows 13 prior case reports of similar disease process, often as the presenting symptom of the HIV disease. Anecdotal reports of effective treatment regimens include steroids and intravenous immune globulin; our patient had a profound response to high-dose steroids. This case report discusses this rare presentation of HIV in hopes to increase awareness amongst clinicians as the incidence and prevalence of HIV increases.

  6. Strategy for Fuel Rod Receipt, Characterization, Sample Allocation for the Demonstration Sister Rods

    SciTech Connect

    Marschman, Steven C.; Warmann, Stephan A.; Rusch, Chris

    2014-03-01

    , inert gas backfilling, and transfer to an Independent Spent Fuel Storage Installation (ISFSI) for multi-year storage. To document the initial condition of the used fuel prior to emplacement in a storage system, “sister ” fuel rods will be harvested and sent to a national laboratory for characterization and archival purposes. This report supports the demonstration by describing how sister rods will be shipped and received at a national laboratory, and recommending basic nondestructive and destructive analyses to assure the fuel rods are adequately characterized for UFDC work. For this report, a hub-and-spoke model is proposed, with one location serving as the hub for fuel rod receipt and characterization. In this model, fuel and/or clad would be sent to other locations when capabilities at the hub were inadequate or nonexistent. This model has been proposed to reduce DOE-NE’s obligation for waste cleanup and decontamination of equipment.

  7. Quasi-static and dynamic response of viscoelastic helical rods

    NASA Astrophysics Data System (ADS)

    Temel, Beytullah; Fırat Çalim, Faruk; Tütüncü, Naki

    2004-04-01

    In this study, the dynamic behaviour of cylindrical helical rods made of linear viscoelastic materials are investigated in the Laplace domain. The governing equations for naturally twisted and curved spatial rods obtained using the Timoshenko beam theory are rewritten for cylindrical helical rods. The curvature of the rod axis, effect of rotary inertia, and shear and axial deformations are considered in the formulation. The material of the rod is assumed to be homogeneous, isotropic and linear viscoelastic. In the viscoelastic material case, according to the correspondence principle, the material constants are replaced with their complex counterparts in the Laplace domain. Ordinary differential equations in scalar form obtained in the Laplace domain are solved numerically using the complementary functions method to calculate the dynamic stiffness matrix of the problem. In the solutions, the Kelvin model is employed. The solutions obtained are transformed to the real space using the Durbin's numerical inverse Laplace transform method. Numerical results for quasi-static and dynamic response of viscoelastic models are presented in the form of graphics.

  8. Nano-rods of zinc oxide in nano-graphene

    NASA Astrophysics Data System (ADS)

    Ortiz, Pedro; Chavira, Elizabeth; Monroy, Marel; Elizalde, José; Santiago, Patricia; Sato, Roberto; Tejeda, Adriana; González, Guillermina; Novelo, Omar; Flores, Carlos

    2014-03-01

    It's of great interest to study the devices based on nano-ZnO and graphene, for their electromagnetic and optical properties to increase the efficiency of solar cells. The graphene multilayers synthesis was done by mechanosynthesis, grinding in a mechanical agate mortar. The zinc oxide nano-rods were synthesized from zinc acetate dihydrate, Ace, (Sigma Aldrich) and ethylene diamine, En, (Sigma Aldrich) with a 1:2 ratio of reagents En/Ace. The ZnO nano-rods in nano-tubes graphene were obtained by mechanosynthesis. The X-ray powder diffraction, shows the shift of C with PDF 12-0212 and ZnO, Zincite PDF 36-1451, both with hexagonal unit cell. The grain size and morphology of graphene (multilayers and nano-tubes), ZnO nano-rods and ZnO-graphene mixture (multilayers, nano-tubes) were observed by scanning electron microscope. Transmission electron microscope, corroborates shown in SEM. Raman spectroscopy, shows the shift of multilayer graphene and the ZnO nano-rods. In photoluminescence measurements, observe the change in intensity in the band defects. Magnetic properties characterization was carried out by Vibrating Sample Magnetometry. We conclude that graphite multilayers dislocated by cutting efforts, forming graphene nano-tubes and encapsulated ZnO nano-rods within graphene.

  9. Braided reinforced composite rods for the internal reinforcement of concrete

    NASA Astrophysics Data System (ADS)

    Gonilho Pereira, C.; Fangueiro, R.; Jalali, S.; Araujo, M.; Marques, P.

    2008-05-01

    This paper reports on the development of braided reinforced composite rods as a substitute for the steel reinforcement in concrete. The research work aims at understanding the mechanical behaviour of core-reinforced braided fabrics and braided reinforced composite rods, namely concerning the influence of the braiding angle, the type of core reinforcement fibre, and preloading and postloading conditions. The core-reinforced braided fabrics were made from polyester fibres for producing braided structures, and E-glass, carbon, HT polyethylene, and sisal fibres were used for the core reinforcement. The braided reinforced composite rods were obtained by impregnating the core-reinforced braided fabric with a vinyl ester resin. The preloading of the core-reinforced braided fabrics and the postloading of the braided reinforced composite rods were performed in three and two stages, respectively. The results of tensile tests carried out on different samples of core-reinforced braided fabrics are presented and discussed. The tensile and bending properties of the braided reinforced composite rods have been evaluated, and the results obtained are presented, discussed, and compared with those of conventional materials, such as steel.

  10. Failure kinetics in borosilicate glass during rod impact

    SciTech Connect

    Orphal, Dennis L.; Anderson, Charles E. Jr.; Behner, Thilo; Hohler, Volker; Wickert, Matthias; Templeton, Douglas W.

    2007-12-12

    Failure front (FF) and penetration velocity have been measured for long gold rods impacting and penetrating borosilicate (BS) glass. Data are obtained by visualizing simultaneously FF propagation with a high speed camera and rod penetration with flash X-rays. Results for BS glass are qualitatively similar to those of DEDF (PbO) glass. FF velocity rapidly decreases from an initial value to a lower, approximately constant value. FF velocity increases with impact velocity, v{sub p}. The FF velocity remains significantly lower than the shear velocity, even at the highest impact velocity tested, about 2.5 km/s. The ratio of the FF velocity to the rod penetration velocity, v{sub F}/u, decreases with increasing v{sub p} and appears to be approaching v{sub F}/u = 1 asymptotically, as observed previously for DEDF glass. The separation of the FF and the tip of the rod decreases with increasing impact velocity. Importantly, since v{sub F}/u{>=}1, the gold rod is always penetrating glass behind the FF.

  11. Rushton's paradox: rod dark adaptation after flash photolysis.

    PubMed Central

    Pugh, E N

    1975-01-01

    1. Rod dark adaptations after a photoregenerating flash and quantum-equivalent 30 sec bleach are found to be in exact agreement, while the measured rhodopsin regenerations are grossly different. This finding confirms and clarifies "Rushton's paradox', the failure of the Dowling-Rushton equation (linking log sensitivity linearly with unregenerated rhodopsin) to account for human rod dark adaptation after flash photolysis. 2. The hypothesis that the agreement between rod dark adaptation curves after a photoregenerating flash and after a quantum-equivalent 30 sec bleach is coincidental is rejected on the basic of two classes of experiments. 3. Rod "bleaching' adaptation is demonstrated to be entirely determined by the number of rhodopsin molecules which absorb at least one quantum in a temporal period T, whose range includes the time interval 600 musec less than or equal T less than or equal 30 sec. This generalization obtains over the entire scotopic energy range (congruent to 3 log units) where rod dark adaptations has been studied. 4. Thus, the state of "bleaching' adaptation is determined by some by-product of the normal chain of events in scotopic excitation. About this by-product three important deductions are made: (i) its production is a monotonic function of the initial effective quantum absorptions; (ii) its production occurs before the metarhodopsin I leads to to metarhodopsin II dark reaction; (iii) it cannot be any photoproduct of the rhodopsin cycle. PMID:1151791

  12. Dysprosium titanate as an absorber material for control rods

    NASA Astrophysics Data System (ADS)

    Risovany, V. D.; Varlashova, E. E.; Suslov, D. N.

    2000-09-01

    Disprosium titanate is an attractive control rod material for the thermal neutron reactors. Its main advantages are: insignificant swelling, no out-gassing under neutron irradiation, rather high neutron efficiency, a high melting point (˜1870°C), non-interaction with the cladding at temperatures above 1000°C, simple fabrication and easily reprocessed non-radioactive waste. It can be used in control rods as pellets and powder. The disprosium titanate control rods have worked off in the MIR reactor for 17 years, in VVER-1000 - for 4 years without any operating problems. After post-irradiation examinations this type of control rod having high lifetime was recommended for the VVER and RBMK. The paper presents the examination results of absorber element dummies containing dysprosium titanate, irradiated in the SM reactor to the neutron fluence of 3.4×10 22 cm -2 ( E>0.1 MeV) and, also, the data on structure, thermal-physical properties of dysprosium titanate, efficiency of dysprosium titanate control rods.

  13. Silica-based rod lens for the medical fiberscope

    NASA Astrophysics Data System (ADS)

    Nakatate, Ken-ichi; Shamoto, Naoki; Oohashi, Tateuki; Tsumanuma, Takashi; Sanada, Kazuo

    1994-07-01

    The ultrathin fiberscope, in which the outer diameter is under 1.0 mm, has made possible the direct observation of narrow portions within the human body. The fiberscope mainly consists of the imagefiber, the objective lens, and the illumination fiber, and each advance of these devices has brought the reduction of the scope-diameter. We have investigated the silica based rod lens for the following merits: (1) The fiberscope can be sterilized by the (gamma) -ray instead of ethylene oxide gas which has the problem of carcinogenicity, because the silica glass has high radiation resistant characteristics. (2) The silica based rod lens can be spliced with the imagefiber without any adhesive agent by using the arc fusion splicing machine. As a result, the reliability of the fiberscope can be significantly improved. The silica based rod lens with 125 micrometers in diameter was fabricated by drawing from preform rod made by the vapor phase axial deposition method. The characteristics of their images were evaluated by the modulation transfer function method. This paper presents the details of the fabrication technique of the silica based rod lens and its characteristics.

  14. On Cherenkov light production by irradiated nuclear fuel rods

    NASA Astrophysics Data System (ADS)

    Branger, E.; Grape, S.; Jacobsson Svärd, S.; Jansson, P.; Andersson Sundén, E.

    2017-06-01

    Safeguards verification of irradiated nuclear fuel assemblies in wet storage is frequently done by measuring the Cherenkov light in the surrounding water produced due to radioactive decays of fission products in the fuel. This paper accounts for the physical processes behind the Cherenkov light production caused by a single fuel rod in wet storage, and simulations are presented that investigate to what extent various properties of the rod affect the Cherenkov light production. The results show that the fuel properties have a noticeable effect on the Cherenkov light production, and thus that the prediction models for Cherenkov light production which are used in the safeguards verifications could potentially be improved by considering these properties. It is concluded that the dominating source of the Cherenkov light is gamma-ray interactions with electrons in the surrounding water. Electrons created from beta decay may also exit the fuel and produce Cherenkov light, and e.g. Y-90 was identified as a possible contributor to significant levels of the measurable Cherenkov light in long-cooled fuel. The results also show that the cylindrical, elongated fuel rod geometry results in a non-isotropic Cherenkov light production, and the light component parallel to the rod's axis exhibits a dependence on gamma-ray energy that differs from the total intensity, which is of importance since the typical safeguards measurement situation observes the vertical light component. It is also concluded that the radial distributions of the radiation sources in a fuel rod will affect the Cherenkov light production.

  15. Fault pseudotachylyte: a coseismic lightning rod

    NASA Astrophysics Data System (ADS)

    Ferre, E. C.; Conder, J. A.; MathanaSekaran, N.; Geissman, J. W.

    2013-12-01

    of melt during the formation of a pseudotachylite vein. The increase in melt temperature is the most important factor affecting electrical conductivity in the fault plane. When the melt temperature rises from 1300 to 2000K, its electrical conductivity increases about 80 times. This implies that once a continuous pseudotachylite sheet-like vein is formed during an earthquake, the vein has a much higher electrical conductivity than its host-rock. The dramatic increase in electrical conductivity along the pseudotachylite plane might be synchronous with the generation of the coseismic electrical current. Thus, regardless of its origin, any electrical current produced during an earthquake will travel along the pseudotachylite plane which acts as a lightning rod. The magnetization of a solid due to an electrical current results from Biot-Savart law which states that an electrical current generates a magnetic field. The solidification of the pseudotachylite vein does not happen at once but proceeds from the margin inwards as an electrical current may still pass through the conducting pseudotachylite. Therefore, the host-rock of the pseudotachylite vein or its solidified margin can be magnetized by a coseismic current.

  16. Plasmonic-cavity model for radiating nano-rod antennas.

    PubMed

    Peng, Liang; Mortensen, N Asger

    2014-01-23

    In this paper, we propose the analytical solution of nano-rod antennas utilizing a cylindrical harmonics expansion. By treating the metallic nano-rods as plasmonic cavities, we derive closed-form expressions for both the internal and the radiated fields, as well as the resonant condition and the radiation efficiency. With our theoretical model, we show that besides the plasmonic resonances, efficient radiation takes advantage of (a) rendering a large value of the rods' radius and (b) a central-fed profile, through which the radiation efficiency can reach up to 70% and even higher in a wide frequency band. Our theoretical expressions and conclusions are general and pave the way for engineering and further optimization of optical antenna systems and their radiation patterns.

  17. Characterisation of Plasma Filled Rod Pinch electron beam diode operation

    NASA Astrophysics Data System (ADS)

    MacDonald, James; Bland, Simon; Chittenden, Jeremy

    2016-10-01

    The plasma filled rod pinch diode (aka PFRP) offers a small radiographic spot size and a high brightness source. It operates in a very similar to plasma opening switches and dense plasma focus devices - with a plasma prefill, supplied via a number of simple coaxial plasma guns, being snowploughed along a thin rod cathode, before detaching at the end. The aim of this study is to model the PFRP and understand the factors that affect its performance, potentially improving future output. Given the dependence on the PFRP on the prefill, we are making detailed measurements of the density (1015-1018 cm-3), velocity, ionisation and temperature of the plasma emitted from a plasma gun/set of plasma guns. This will then be used to provide initial conditions to the Gorgon 3D MHD code, and the dynamics of the entire rod pinch process studied.

  18. Deformation of liquid-liquid interfaces by a rotating rod

    NASA Astrophysics Data System (ADS)

    Zhao, C. W.; Gentric, C.; Dietrich, N.; Ma, Y. G.; Li, Huai Z.

    2017-07-01

    The present study aims at investigating the deformation mechanism of liquid-liquid interfaces by both the experimental and numerical approaches. The experiments reveal that the topology of an initial flat interface composed of Newtonian aqueous and Newtonian oil phases can be modulated as climbing or descending along a rotating rod according to the ratio of the kinematic viscosity between these two liquid phases. The measurements of the fluid flow fields by particle image velocimetry highlight the relationship between the appearance of the Taylor-Couette instability in the less viscous phase and the interface's orientation. The increasing rod rotation speed expands the Taylor-Couette vortices and then intensifies the magnitude of the interface deformation. The numerical simulation by the volume of fluid method is in qualitative agreement with the experimental results, in particular the interface shape and the qualitative influence of different parameters, even under very high rotation speeds of the rod.

  19. Simulations of optical sensors fabricated from metallic rods couplers

    NASA Astrophysics Data System (ADS)

    Singh, M. R.; Balakrishanan, Shankar

    2014-03-01

    We have developed the optical sensing mechanism of photonic couplers fabricated from the periodically arranged metallic rods. The metallic rod lattice is embedded between two dielectric material waveguides. This structure is called metallic coupler. Using the transfer matrix method, expressions for the reflection and transmission coefficients of electromagnetic wave propagating in waveguides have been obtained. We found that for certain energies, the electromagnetic wave is totally reflected from the coupler. Similarly, for a certain energy range the light is totally transmitted. It has also been found that by changing the periodicity of the metallic rods, the transmitted energy can be reflected. The periodicity of the metallic lattice can be modified by applying an external stress or pressure. In other words, the system can be used as stress and pressure sensors. The present findings can be used to make new types photonic sensors.

  20. Control Rod Reactivity Curves for the Annular Core Research Reactor

    NASA Astrophysics Data System (ADS)

    Depriest, K. Russell; Kajder, Karen C.; Frye, Jason N.; Denman, Matthew R.

    2009-08-01

    Experiments were conducted at the Annular Core Research Reactor (ACRR) to increase the fidelity of the control rod integral reactivity worth curve. This experiment series was designed to refine the integral reactivity curve used for pulse yield prediction and eliminate the need for operator compensation in the pulse setup. The experiment series consisted of delayed critical and positive period measurements with various ACRR cavity configurations. An improved integral reactivity worth curve for the ACRR control rods has been constructed using the positive period measurements, the delayed critical measurements, and radiation transport modeling of the reactor. A series of prompt period measurements is used to validate that the new control rod curve more accurately predicts the energy yield of the pulse operations. The new reactivity worth curve is compared with the current curve that was developed using traditional approaches.

  1. Protons block the dark current of isolated retinal rods.

    PubMed

    Mueller, P; Pugh, E N

    1983-04-01

    Membrane currents of isolated frog rods were recorded with the suction pipette technique and tested by perfusion techniques for their sensitivity to H+. The following facts have been established. (i) Increased [H+] suppresses the Na+ conductance of the outer segment rapidly and reversibly. (ii) H+ acts in the rod interior. (iii) The [H+] necessary to cause a 50% decrement in Na+ conductance is inversely related to the [Ca2+] over 5 orders of magnitude. (iv) The sensitivity to H+ and the sensitivity to light, as a function of [Ca2+], have the same slope. Thus, H+ act like light in effecting membrane current suppression but behave as if their effect is mediated through Ca2+. Based on these results and properties of rod disk membrane phosphodiesterase, we propose that protons produced in the light-activated hydrolysis of cGMP liberate Ca2+ from the disks by ion exchange.

  2. Coiling of elastic rods from a geometric perspective

    NASA Astrophysics Data System (ADS)

    Jawed, Mohammad; Brun, Pierre-Thomas; Reis, Pedro

    2015-03-01

    We present results from a systematic numerical investigation of the pattern formation of coiling obtained when a slender elastic rod is deployed onto a moving substrate; a system known as the elastic sewing machine (ESM). The Discrete Elastic Rods method is employed to explore the parameter space, construct phase diagrams, identify their phase boundaries and characterize the morphology of the patterns. The nontrivial geometric nonlinearities are described in terms of the gravito-bending length and the deployment height. Our results are interpreted using a reduced geometric model for the evolution of the position of the contact point with the belt and the curvature of the rod in its neighborhood. This geometric model reproduces all of the coiling patterns of the ESM, which allows us to establish a universal link between our elastic problem and the analogous patterns obtained when depositing a viscous thread onto a moving surface; a well-known system referred to as the fluid mechanical sewing machine.

  3. Undulatory buckling of a rod constrained by an elastic matrix

    NASA Astrophysics Data System (ADS)

    Liu, Jia; Su, Tianxiang; Lopez-Pamies, Oscar; Reis, Pedro; Bertoldi, Katia

    2012-02-01

    Elastic instabilities of rods constrained by an elastic matrix and subjected to axial compression have long been recognized as essential for structural applications in the context of failure mitigation and, more recently, towards exploitation of functionality. Relevant fields for this class of problems include drilling, biomedical instrumentation and root growth in plants. We explore the two possible scenarios observed when, above a threshold load, compression is applied to a rod constrained by a matrix: i) the rod can develop a planar oscillatory solution (sinusoidal buckling) or ii) it can take the configuration of a helix (helical buckling). We identify the principal parameters of this system, perform a systematic parametric study and rationalize the phase diagram through a hybrid of theoretical and numerical analyses. Particular attention is devoted to the effect of the mechanical properties of the constraining matrix which is found to have a critical influence on this buckling scenario.

  4. Noise Radiation from Single and Multiple Rod Configurations

    NASA Technical Reports Server (NTRS)

    Hutcheson, Florence V.; Brooks, Thomas F.

    2006-01-01

    Acoustic measurements were performed on single and multiple rod configurations to study the effect of Reynolds number, surface roughness, freestream turbulence, proximity and wake interference on the radiated noise. The Reynolds number ranged from 3.8 x 10(exp 3) to 10(exp 5). Directivity measurements were performed to determine how well the dipole assumption for the radiation of vortex shedding noise holds for the different model configurations tested. The dependence of the peak Sound Pressure Level on velocity was also examined. Several concepts for the reduction of the noise radiating from cylindrical rods were tested. It was shown that wire wraps and collar distributions could be used to significantly reduce the noise radiating from rods in tandem configurations.

  5. Tensile Characterization of FRP Rods for Reinforced Concrete Structures

    NASA Astrophysics Data System (ADS)

    Micelli, F.; Nanni, A.

    2003-07-01

    The application of FRP rods as an internal or external reinforcement in new or damaged concrete structures is based on the development of design equations that take into account the mechanical properties of FRP material systems.The measurement of mechanical characteristics of FRP requires a special anchoring and protocol, since it is well known that these characteristics depend on the direction and content of fibers. In this study, an effective tensile test method is described for the mechanical characterization of FRP rods. Twelve types of glass and carbon FRP specimens with different sizes and surface characteristics were tested to validate the procedure proposed. In all, 79 tensile tests were performed, and the results obtained are discussed in this paper. Recommendations are given for specimen preparation and test setup in order to facilitate the further investigation and standardization of the FRP rods used in civil engineering.

  6. Prominent 946 lines induced from flashlamp pumped Nd: YAG rod

    NASA Astrophysics Data System (ADS)

    Bidin, Noriah; Zainal, Roslinda; Daud, Yaacob Mat; Pourmand, Seyed Ebrahim; Bakhtiar, Hazri

    2012-06-01

    Spectroscopic properties of Nd:YAG laser rod pumped by a new developed flashlamp is investigated. A new power supply is constructed to power xenon flashlamp. A 1 at.% Nd:YAG laser rod is transversely pumped by the flashlamp and stabilized by a water cooling system operated at ambient temperature of 20°C. The absorption and emission spectrum of the flashlamp pumped Nd:YAG rod is analyzed via spectroscopy technique. The peak absorption line is identified to be at 882 nm. The dominant emission line obtained from transition 4F3/2→4I9/2 comprised of quasi three level laser at 938.5 and 946 nm with the corresponding cross section of 2.42×10-19cm2 and 3.04×10-19cm2 respectively. This cross section is found almost ten times greater than the usual one.

  7. Dynamic features of rod-shaped Au nanoclusters

    NASA Astrophysics Data System (ADS)

    So, Woong Young; Das, Anindita; Wang, Shuxin; Zhao, Shuo; Byun, Hee Young; Lee, Dana; Kumar, Santosh; Jin, Rongchao; Peteanu, Linda A.

    2015-08-01

    Gold nanoclusters hold many potential applications such as biosensing and optics due to their emission characteristics, small size, and non-toxicity. However, their low quantum yields remain problematic for further applications, and their fluorescence mechanism is still unclear. To increase the low quantum yields, various methods have been performed: doping, tuning structures, and changing number of gold atoms. In the past, most characterizations have been performed on spherical shaped nanoclusters; in this paper, several characterizations of various rod-shaped Au nanoclusters specifically on Au25 are shown. It has been determined that the central gold atom in Au25 nano-rod is crucial in fluorescence. Furthermore, single molecule analysis of silver doped Au25 nano-rod revealed that it has more photo-stability than conjugated polymers and quantum dots.

  8. Modeling a diode pumped Nd: YAG rod laser

    NASA Astrophysics Data System (ADS)

    Shu, Hong; Chen, Ying; Bass, Michael; Acharekar, Madhu A.

    2006-02-01

    We evaluate the performance potential of a diode pumped Nd: YAG rod laser by finding the absorbed pump distribution using ASAP, pump induced thermal lensing, gain medium surface distortion and stresses using FEMLAB and depolarization losses using MATLAB. Beam propagation in the optically distorted Nd:YAG rod and the free space part of the cavity, and the output laser beam were determined with a computational scheme we developed which employs the beam propagation method combined with sparse matrix technology. We propose a special cavity design that can select the spatial eigen mode shape of the laser and simultaneously compensate for pump induced thermal lensing, gain medium surface distortion and birefringence. The converged solutions calculated this special cavity design give both high extraction efficiency and good output beam quality. Sensitivity of the output beam to mirror tilt, thermal induced mirror distortion, and errors in the cavity length or the optical distortions in the rod were also calculated.

  9. Failure of latch mechanism for motion control of safety rods

    SciTech Connect

    Yau, W.W.F.; Leader, D.R.

    1992-01-16

    During safety rod tests in K-reactor prior to startup, one safety rod could not be lifted because the ``button`` broke off and became lodged in the mechanism. Examination of the failed latch assembly along with other assemblies from both K-Area and L-Area revealed several missing buttons as well as severely deformed ``jaw hanger extensions.`` We participated in the investigation of the damage by request of the Reactor Restart Section. Based on our study of the latch mechanism, the modifications to the ``safety rod extension,`` and the operating history of the machine, this memorandum describes the causes of the observed damage with experimental evidence and calculations to support the findings. 3 refs.

  10. Failure of latch mechanism for motion control of safety rods

    SciTech Connect

    Yau, W.W.F.; Leader, D.R.

    1992-01-16

    During safety rod tests in K-reactor prior to startup, one safety rod could not be lifted because the button'' broke off and became lodged in the mechanism. Examination of the failed latch assembly along with other assemblies from both K-Area and L-Area revealed several missing buttons as well as severely deformed jaw hanger extensions.'' We participated in the investigation of the damage by request of the Reactor Restart Section. Based on our study of the latch mechanism, the modifications to the safety rod extension,'' and the operating history of the machine, this memorandum describes the causes of the observed damage with experimental evidence and calculations to support the findings. 3 refs.

  11. Stability and failure analysis of steering tie-rod

    NASA Astrophysics Data System (ADS)

    Jiang, GongFeng; Zhang, YiLiang; Xu, XueDong; Ding, DaWei

    2008-11-01

    A new car in operation of only 8,000 km, because of malfunction, resulting in lost control and rammed into the edge of the road, and then the basic vehicle scrapped. According to the investigation of the site, it was found that the tie-rod of the car had been broken. For the subjective analysis of the accident and identifying the true causes of rupture of the tierod, a series of studies, from the angle of theory to experiment on the bended broken tie-rod, were conducted. The mechanical model was established; the stability of the defective tie-rod was simulated based on ANSYS software. Meanwhile, the process of the accident was simulated considering the effect of destabilization of different vehicle speed and direction of the impact. Simultaneously, macro graphic test, chemical composition analysis, microstructure analysis and SEM analysis of the fracture were implemented. The results showed that: 1) the toughness of the tie-rod is at a normal level, but there is some previous flaws. One quarter of the fracture surface has been cracked before the accident. However, there is no relationship between the flaw and this incident. The direct cause is the dynamic instability leading to the large deformation of impact loading. 2) The declining safety factor of the tie-rod greatly due to the previous flaws; the result of numerical simulation shows that previous flaw is the vital factor of structure instability, on the basis of the comparison of critical loads of the accident tie-rod and normal. The critical load can decrease by 51.3% when the initial defect increases 19.54% on the cross-sectional area, which meets the Theory of Koiter.

  12. Multistep ion exchange processes of gradient refractive index rod lens.

    PubMed

    Lv, Hao; Liu, Aimei; Tong, Jufang; Yi, Xunong; Li, Qianguang; Wang, Xinmin; Ding, Yaoming

    2011-01-01

    A mathematical model for research on the refractive index profile (RIP) of multistep ion exchange processes (IEPs) of gradient refractive index rod lenses (GRINs) is established by the different initial condition and boundary condition, based on the Fickian diffusion equation. GRIN rod lenses have been fabricated using the three-step IEPs. Research results indicate that the experimental deviations of refractive index (DRI) are in good agreement with the theoretical data. The DRI of three-step IEPs is superior to the one- and two-step IEPs and smaller than 10(-5).

  13. Additional information for impact response of the restart safety rods

    SciTech Connect

    Yau, W.W.F.

    1991-10-14

    WSRC-RP-91-677 studied the structural response of the safety rods under the conditions of brake failure and accidental release. It was concluded that the maximum impact loading to the safety rod is 6020 pounds based on conservative considerations that energy dissipation attributable to fluid resistance and reactor superstructure flexibility. The staffers of the Defense Nuclear Facility Safety Board reviewed the results and inquired about the extent of conservatism. By request of the RESTART team, I reassessed the impact force due to these conservative assumptions. This memorandum reports these assessments.

  14. Compressional and torsional wave amplitudes in rods with periodic structures

    NASA Astrophysics Data System (ADS)

    Morales, A.; Flores, J.; Gutierrez, L.; Mendez-Sanchez, R. A.

    2002-11-01

    To measure and detect elastic waves in metallic rods a low-frequency electromagnetic-acoustic transducer has been developed. Frequencies range from a few hertz up to hundreds of kilohertz. With appropriate configuration of the transducer, compressional or torsional waves can be selectively excited or detected. Although the transducer can be used in many different situations, it has been tested and applied to a locally periodic rod, which consists of a finite number of unit cells. The measured wave amplitudes are compared with theoretical ones, obtained with the one-dimensional transfer matrix method, and excellent agreement is obtained. copyright 2002 Acoustical Society of America.

  15. Dendrites of rod bipolar cells sprout in normal aging retina.

    PubMed

    Liets, Lauren C; Eliasieh, Kasra; van der List, Deborah A; Chalupa, Leo M

    2006-08-08

    The aging nervous system is known to manifest a variety of degenerative and regressive events. Here we report the unexpected growth of dendrites in the retinas of normal old mice. The dendrites of many rod bipolar cells in aging mice were observed to extend well beyond their normal strata within the outer plexiform layer to innervate the outer nuclear layer where they appeared to form contacts with the spherules of rod photoreceptors. Such dendritic sprouting increased with age and was evident at all retinal eccentricities. These results provide evidence of retinal plasticity associated with normal aging.

  16. Additional information for impact response of the restart safety rods

    SciTech Connect

    Yau, W.W.F.

    1991-10-14

    WSRC-RP-91-677 studied the structural response of the safety rods under the conditions of brake failure and accidental release. It was concluded that the maximum impact loading to the safety rod is 6020 pounds based on conservative considerations that energy dissipation attributable to fluid resistance and reactor superstructure flexibility. The staffers of the Defense Nuclear Facility Safety Board reviewed the results and inquired about the extent of conservatism. By request of the RESTART team, I reassessed the impact force due to these conservative assumptions. This memorandum reports these assessments.

  17. Lightweight piston-rod assembly for a reciprocating machine

    DOEpatents

    Corey, John A.; Walsh, Michael M.

    1986-01-01

    In a reciprocating machine, there is provided a hollow piston including a dome portion on one end and a base portion on the opposite end. The base portion includes a central bore into which a rod is hermetically fixed in radial and angular alignment. The extending end of the rod has a reduced diameter portion adapted to fit into the central bore of a second member such as a cross-head assembly, and to be secured thereto in radial and axial alignment with the piston.

  18. NEUTRONIC REACTOR CONTROL ROD AND METHOD OF FABRICATION

    DOEpatents

    Porembka, S.W. Jr.

    1961-06-27

    A reactor control rod formed from a compacted powder dispersion is patented. The rod consists of titanium sheathed with a cladding alloy. The cladding alloy contains 1.3% to 1.6% by weight of tin, 0.07% to 0.12% by weight of chromium, 0.04% to 0.08% by weight of nickel, 0.09% to 0.16% by weight of iron, carbon not exceeding 0.05%, less than 0.5% by weight of incidental impurities, and the balance zirconium.

  19. Computer simulations to study the effect of adiabatic heating on rod penetration

    SciTech Connect

    Reaugh, J.E.

    1993-08-01

    We use computer simulations to help us understand the experimental observation that depleted uranium (DU) rods penetrate more steel than equal density tungsten alloy (WA) rods, and that this advantage depends on velocity and fineness ratio. Our simulations used thermal softening. Although the DU rods exhibit shear fracture instead, both phenomena result in a loss of hoop strength, and help to keep the projectile residue from interfering with the incoming rod. Our simulations show that rods of DU (or other alloy with strong thermal softening) penetrate more steel than rods of WA (for alloys with little thermal softening), and show velocity and fineness ratio dependencies that are in qualitative agreement with experiment.

  20. The Function of Guanylate Cyclase 1 and Guanylate Cyclase 2 in Rod and Cone Photoreceptors*S

    PubMed Central

    Baehr, Wolfgang; Karan, Sukanya; Maeda, Tadao; Luo, Dong-Gen; Li, Sha; Darin Bronson, J.; Watt, Carl B.; Yau, King-Wai; Frederick, Jeanne M.; Palczewski, Krzysztof

    2007-01-01

    Retinal guanylate cyclases 1 and 2 (GC1 and GC2) are responsible for synthesis of cyclic GMP in rods and cones, but their individual contributions to phototransduction are unknown. We report here that the deletion of both GC1 and GC2 rendered rod and cone photoreceptors nonfunctional and unstable. In the rod outer segments of GC double knock-out mice, guanylate cyclase-activating proteins 1 and 2, and cyclic GMP phosphodiesterase were undetectable, although rhodopsin and transducin α-subunit were mostly unaffected. Outer segment membranes of GC1−/− and GC double knock-out cones were destabilized and devoid of cone transducin (α- and γ-subunits), cone phosphodiesterase, and G protein-coupled receptor kinase 1, whereas cone pigments were present at reduced levels. Real time reverse transcription-PCR analyses demonstrated normal RNA transcript levels for the down-regulated proteins, indicating that down-regulation is posttranslational. We interpret these results to demonstrate an intrinsic requirement of GCs for stability and/or transport of a set of membrane-associated phototransduction proteins. PMID:17255100