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Sample records for reliability organizations theory

  1. High reliability organizations (HROs).

    PubMed

    Sutcliffe, Kathleen M

    2011-06-01

    Academic and professional disciplines, such as organisation and management theory, psychology, sociology and engineering, have, for years, grappled with the multidisciplinary issues of safety and accident prevention. However, these ideas are just beginning to enrich research on safety in medicine. This article examines a domain of research on system safety - the High Reliability Organization (HRO) paradigm. HROs operate in hazardous conditions, but have fewer than their fair share of adverse events. HROs are committed to safety at the highest level and adopt a special approach to its pursuit. The attributes and operating dynamics of the best HROs provide a template on which to better understand how safe and reliable performance can be achieved under trying conditions, and this may be useful to researchers and caregivers who seek to improve safety and reliability in health care. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Stable unstable reliability theory.

    PubMed

    Thomas, Hoben; Lohaus, Arnold; Domsch, Holger

    2012-05-01

    Classical reliability theory assumes that individuals have identical true scores on both testing occasions, a condition described as stable. If some individuals' true scores are different on different testing occasions, described as unstable, the estimated reliability can be misleading. A model called stable unstable reliability theory (SURT) frames stability or instability as an empirically testable question. SURT assumes a mixed population of stable and unstable individuals in unknown proportions, with w(i) the probability that individual i is stable. w(i) becomes i's test score weight which is used to form a weighted correlation coefficient r(w) which is reliability under SURT. If all w(i) = 1 then r(w) is the classical reliability coefficient; thus classical theory is a special case of SURT. Typically r(w) is larger than the conventional reliability r, and confidence intervals on true scores are typically shorter than conventional intervals. r(w) is computed with routines in a publicly available R package. ©2011 The British Psychological Society.

  3. Theory of reliable systems

    NASA Technical Reports Server (NTRS)

    Meyer, J. F.

    1975-01-01

    An attempt was made to refine the current notion of system reliability by identifying and investigating attributes of a system which are important to reliability considerations. Techniques which facilitate analysis of system reliability are included. Special attention was given to fault tolerance, diagnosability, and reconfigurability characteristics of systems.

  4. Decision theory in structural reliability

    NASA Technical Reports Server (NTRS)

    Thomas, J. M.; Hanagud, S.; Hawk, J. D.

    1975-01-01

    Some fundamentals of reliability analysis as applicable to aerospace structures are reviewed, and the concept of a test option is introduced. A decision methodology, based on statistical decision theory, is developed for determining the most cost-effective design factor and method of testing for a given structural assembly. The method is applied to several Saturn V and Space Shuttle structural assemblies as examples. It is observed that the cost and weight features of the design have a significant effect on the optimum decision.

  5. Decision theory in structural reliability

    NASA Technical Reports Server (NTRS)

    Thomas, J. M.; Hanagud, S.; Hawk, J. D.

    1975-01-01

    Some fundamentals of reliability analysis as applicable to aerospace structures are reviewed, and the concept of a test option is introduced. A decision methodology, based on statistical decision theory, is developed for determining the most cost-effective design factor and method of testing for a given structural assembly. The method is applied to several Saturn V and Space Shuttle structural assemblies as examples. It is observed that the cost and weight features of the design have a significant effect on the optimum decision.

  6. (Centralized Reliability Data Organization (CRDO))

    SciTech Connect

    Haire, M J

    1987-04-21

    One of the primary goals of the Centralized Reliability Data Organization (CREDO) is to be an international focal point for the collection, analysis, and dissemination of liquid metal reactor (LMR) component reliability, availability, and maintainability (RAM) data. During FY-1985, the Department of Energy (DOE) entered into a Specific Memorandum of Agreement (SMA) with Japan's Power Reactor and Nuclear Fuel Development Corporation (PNC) regarding cooperative data exchange efforts. This agreement was CREDO's first step toward internationalization and represented an initial realization of the previously mentioned goal. DOE's interest in further internationalization of the CREDO system was the primary motivation for the traveler's attendance at the Reliability '87 conference.

  7. Becoming a high reliability organization.

    PubMed

    Christianson, Marlys K; Sutcliffe, Kathleen M; Miller, Melissa A; Iwashyna, Theodore J

    2011-01-01

    Aircraft carriers, electrical power grids, and wildland firefighting, though seemingly different, are exemplars of high reliability organizations (HROs)--organizations that have the potential for catastrophic failure yet engage in nearly error-free performance. HROs commit to safety at the highest level and adopt a special approach to its pursuit. High reliability organizing has been studied and discussed for some time in other industries and is receiving increasing attention in health care, particularly in high-risk settings like the intensive care unit (ICU). The essence of high reliability organizing is a set of principles that enable organizations to focus attention on emergent problems and to deploy the right set of resources to address those problems. HROs behave in ways that sometimes seem counterintuitive--they do not try to hide failures but rather celebrate them as windows into the health of the system, they seek out problems, they avoid focusing on just one aspect of work and are able to see how all the parts of work fit together, they expect unexpected events and develop the capability to manage them, and they defer decision making to local frontline experts who are empowered to solve problems. Given the complexity of patient care in the ICU, the potential for medical error, and the particular sensitivity of critically ill patients to harm, high reliability organizing principles hold promise for improving ICU patient care.

  8. Creating Highly Reliable Accountable Care Organizations.

    PubMed

    Vogus, Timothy J; Singer, Sara J

    2016-12-01

    Accountable Care Organizations' (ACOs) pursuit of the triple aim of higher quality, lower cost, and improved population health has met with mixed results. To improve the design and implementation of ACOs we look to organizations that manage similarly complex, dynamic, and tightly coupled conditions while sustaining exceptional performance known as high-reliability organizations. We describe the key processes through which organizations achieve reliability, the leadership and organizational practices that enable it, and the role that professionals can play when charged with enacting it. Specifically, we present concrete practices and processes from health care organizations pursuing high-reliability and from early ACOs to illustrate how the triple aim may be met by cultivating mindful organizing, practicing reliability-enhancing leadership, and identifying and supporting reliability professionals. We conclude by proposing a set of research questions to advance the study of ACOs and high-reliability research.

  9. Organization Theory as Ideology.

    ERIC Educational Resources Information Center

    Greenfield, Thomas B.

    The theory that organizations are ideological inventions of the human mind is discussed. Organizational science is described as an ideology which is based upon social concepts and experiences. The main justification for organizational theory is that it attempts to answer why we behave as we do in social organizations. Ways in which ideas and…

  10. Creating High Reliability in Health Care Organizations

    PubMed Central

    Pronovost, Peter J; Berenholtz, Sean M; Goeschel, Christine A; Needham, Dale M; Sexton, J Bryan; Thompson, David A; Lubomski, Lisa H; Marsteller, Jill A; Makary, Martin A; Hunt, Elizabeth

    2006-01-01

    Objective The objective of this paper was to present a comprehensive approach to help health care organizations reliably deliver effective interventions. Context Reliability in healthcare translates into using valid rate-based measures. Yet high reliability organizations have proven that the context in which care is delivered, called organizational culture, also has important influences on patient safety. Model for Improvement Our model to improve reliability, which also includes interventions to improve culture, focuses on valid rate-based measures. This model includes (1) identifying evidence-based interventions that improve the outcome, (2) selecting interventions with the most impact on outcomes and converting to behaviors, (3) developing measures to evaluate reliability, (4) measuring baseline performance, and (5) ensuring patients receive the evidence-based interventions. The comprehensive unit-based safety program (CUSP) is used to improve culture and guide organizations in learning from mistakes that are important, but cannot be measured as rates. Conclusions We present how this model was used in over 100 intensive care units in Michigan to improve culture and eliminate catheter-related blood stream infections—both were accomplished. Our model differs from existing models in that it incorporates efforts to improve a vital component for system redesign—culture, it targets 3 important groups—senior leaders, team leaders, and front line staff, and facilitates change management—engage, educate, execute, and evaluate for planned interventions. PMID:16898981

  11. High Reliability Organizations in Education. Noteworthy Perspectives

    ERIC Educational Resources Information Center

    Eck, James H.; Bellamy, G. Thomas; Schaffer, Eugene; Stringfield, Sam; Reynolds, David

    2011-01-01

    The authors of this monograph assert that by assisting school systems to more closely resemble "high reliability" organizations (HROs) that already exist in other industries and benchmarking against top-performing education systems from around the globe, America's school systems can transform themselves from compliance-driven…

  12. Are hospitals becoming high reliability organizations?

    PubMed

    Bagnara, Sebastiano; Parlangeli, Oronzo; Tartaglia, Riccardo

    2010-09-01

    High Reliability Organizations (HROs) are complex systems in which many accidents and adverse events that could occur within those systems or at the interfaces with other systems are actually avoided or prevented. Many organizations in high-risk industries have successfully implemented HRO approaches. In recent years, initiatives have been undertaken aimed at transforming hospitals into HROs. Actually, despite some improvements, these initiatives have not shown the expected results. In this paper, we discuss the possible reasons for such outcomes. We will show that, when compared with traditional HROs, hospitals are undoubtedly high-risk organizations, but have specificities and experience systemic socio-organizational barriers that make them difficult to transform into HROs.

  13. 18 CFR 39.3 - Electric Reliability Organization certification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Electric Reliability... CERTIFICATION OF THE ELECTRIC RELIABILITY ORGANIZATION; AND PROCEDURES FOR THE ESTABLISHMENT, APPROVAL, AND ENFORCEMENT OF ELECTRIC RELIABILITY STANDARDS § 39.3 Electric Reliability Organization certification. (a) Any...

  14. 18 CFR 39.3 - Electric Reliability Organization certification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Electric Reliability... CERTIFICATION OF THE ELECTRIC RELIABILITY ORGANIZATION; AND PROCEDURES FOR THE ESTABLISHMENT, APPROVAL, AND ENFORCEMENT OF ELECTRIC RELIABILITY STANDARDS § 39.3 Electric Reliability Organization certification. (a) Any...

  15. High Reliability Organizations--Medication Safety.

    PubMed

    Yip, Luke; Farmer, Brenna

    2015-06-01

    High reliability organizations (HROs), such as the aviation industry, successfully engage in high-risk endeavors and have low incidence of adverse events. HROs have a preoccupation with failure and errors. They analyze each event to effect system wide change in an attempt to mitigate the occurrence of similar errors. The healthcare industry can adapt HRO practices, specifically with regard to teamwork and communication. Crew resource management concepts can be adapted to healthcare with the use of certain tools such as checklists and the sterile cockpit to reduce medication errors. HROs also use The Swiss Cheese Model to evaluate risk and look for vulnerabilities in multiple protective barriers, instead of focusing on one failure. This model can be used in medication safety to evaluate medication management in addition to using the teamwork and communication tools of HROs.

  16. Neurology objective structured clinical examination reliability using generalizability theory.

    PubMed

    Blood, Angela D; Park, Yoon Soo; Lukas, Rimas V; Brorson, James R

    2015-11-03

    This study examines factors affecting reliability, or consistency of assessment scores, from an objective structured clinical examination (OSCE) in neurology through generalizability theory (G theory). Data include assessments from a multistation OSCE taken by 194 medical students at the completion of a neurology clerkship. Facets evaluated in this study include cases, domains, and items. Domains refer to areas of skill (or constructs) that the OSCE measures. G theory is used to estimate variance components associated with each facet, derive reliability, and project the number of cases required to obtain a reliable (consistent, precise) score. Reliability using G theory is moderate (Φ coefficient = 0.61, G coefficient = 0.64). Performance is similar across cases but differs by the particular domain, such that the majority of variance is attributed to the domain. Projections in reliability estimates reveal that students need to participate in 3 OSCE cases in order to increase reliability beyond the 0.70 threshold. This novel use of G theory in evaluating an OSCE in neurology provides meaningful measurement characteristics of the assessment. Differing from prior work in other medical specialties, the cases students were randomly assigned did not influence their OSCE score; rather, scores varied in expected fashion by domain assessed. © 2015 American Academy of Neurology.

  17. Neurology objective structured clinical examination reliability using generalizability theory

    PubMed Central

    Park, Yoon Soo; Lukas, Rimas V.; Brorson, James R.

    2015-01-01

    Objectives: This study examines factors affecting reliability, or consistency of assessment scores, from an objective structured clinical examination (OSCE) in neurology through generalizability theory (G theory). Methods: Data include assessments from a multistation OSCE taken by 194 medical students at the completion of a neurology clerkship. Facets evaluated in this study include cases, domains, and items. Domains refer to areas of skill (or constructs) that the OSCE measures. G theory is used to estimate variance components associated with each facet, derive reliability, and project the number of cases required to obtain a reliable (consistent, precise) score. Results: Reliability using G theory is moderate (Φ coefficient = 0.61, G coefficient = 0.64). Performance is similar across cases but differs by the particular domain, such that the majority of variance is attributed to the domain. Projections in reliability estimates reveal that students need to participate in 3 OSCE cases in order to increase reliability beyond the 0.70 threshold. Conclusions: This novel use of G theory in evaluating an OSCE in neurology provides meaningful measurement characteristics of the assessment. Differing from prior work in other medical specialties, the cases students were randomly assigned did not influence their OSCE score; rather, scores varied in expected fashion by domain assessed. PMID:26432851

  18. Improving Patient Safety in Hospitals: Contributions of High-Reliability Theory and Normal Accident Theory

    PubMed Central

    Tamuz, Michal; Harrison, Michael I

    2006-01-01

    Objective To identify the distinctive contributions of high-reliability theory (HRT) and normal accident theory (NAT) as frameworks for examining five patient safety practices. Data Sources/Study Setting We reviewed and drew examples from studies of organization theory and health services research. Study Design After highlighting key differences between HRT and NAT, we applied the frames to five popular safety practices: double-checking medications, crew resource management (CRM), computerized physician order entry (CPOE), incident reporting, and root cause analysis (RCA). Principal Findings HRT highlights how double checking, which is designed to prevent errors, can undermine mindfulness of risk. NAT emphasizes that social redundancy can diffuse and reduce responsibility for locating mistakes. CRM promotes high reliability organizations by fostering deference to expertise, rather than rank. However, HRT also suggests that effective CRM depends on fundamental changes in organizational culture. NAT directs attention to an underinvestigated feature of CPOE: it tightens the coupling of the medication ordering process, and tight coupling increases the chances of a rapid and hard-to-contain spread of infrequent, but harmful errors. Conclusions Each frame can make a valuable contribution to improving patient safety. By applying the HRT and NAT frames, health care researchers and administrators can identify health care settings in which new and existing patient safety interventions are likely to be effective. Furthermore, they can learn how to improve patient safety, not only from analyzing mishaps, but also by studying the organizational consequences of implementing safety measures. PMID:16898984

  19. [Qualitative analysis: theory, steps and reliability].

    PubMed

    Minayo, Maria Cecília de Souza

    2012-03-01

    This essay seeks to conduct in-depth analysis of qualitative research, based on benchmark authors and the author's own experience. The hypothesis is that in order for an analysis to be considered reliable, it needs to be based on structuring terms of qualitative research, namely the verbs 'comprehend' and 'interpret', and the nouns 'experience', 'common sense' and 'social action'. The 10 steps begin with the construction of the scientific object by its inclusion on the national and international agenda; the development of tools that make the theoretical concepts tangible; conducting field work that involves the researcher empathetically with the participants in the use of various techniques and approaches, making it possible to build relationships, observations and a narrative with perspective. Finally, the author deals with the analysis proper, showing how the object, which has already been studied in all the previous steps, should become a second-order construct, in which the logic of the actors in their diversity and not merely their speech predominates. The final report must be a theoretic, contextual, concise and clear narrative.

  20. Applying Organization Theory to Understanding the Adoption and Implementation of Accountable Care Organizations: Commentary.

    PubMed

    Shortell, Stephen M

    2016-12-01

    This commentary highights the key arguments and contributions of institutional thoery, transaction cost economics (TCE) theory, high reliability theory, and organizational learning theory to understanding the development and evolution of Accountable Care Organizations (ACOs). Institutional theory and TCE theory primarily emphasize the external influences shaping ACOs while high reliability theory and organizational learning theory underscore the internal fctors influencing ACO perfromance. A framework based on Implementation Science is proposed to conside the multiple perspectives on ACOs and, in particular, their abiity to innovate to achieve desired cost, quality, and population health goals.

  1. Design of high reliability organizations in health care

    PubMed Central

    Carroll, J S; Rudolph, J W

    2006-01-01

    To improve safety performance, many healthcare organizations have sought to emulate high reliability organizations from industries such as nuclear power, chemical processing, and military operations. We outline high reliability design principles for healthcare organizations including both the formal structures and the informal practices that complement those structures. A stage model of organizational structures and practices, moving from local autonomy to formal controls to open inquiry to deep self‐understanding, is used to illustrate typical challenges and design possibilities at each stage. We suggest how organizations can use the concepts and examples presented to increase their capacity to self‐design for safety and reliability. PMID:17142607

  2. Design of high reliability organizations in health care.

    PubMed

    Carroll, J S; Rudolph, J W

    2006-12-01

    To improve safety performance, many healthcare organizations have sought to emulate high reliability organizations from industries such as nuclear power, chemical processing, and military operations. We outline high reliability design principles for healthcare organizations including both the formal structures and the informal practices that complement those structures. A stage model of organizational structures and practices, moving from local autonomy to formal controls to open inquiry to deep self-understanding, is used to illustrate typical challenges and design possibilities at each stage. We suggest how organizations can use the concepts and examples presented to increase their capacity to self-design for safety and reliability.

  3. Seeking high reliability in primary care: Leadership, tools, and organization.

    PubMed

    Weaver, Robert R

    2015-01-01

    Leaders in health care increasingly recognize that improving health care quality and safety requires developing an organizational culture that fosters high reliability and continuous process improvement. For various reasons, a reliability-seeking culture is lacking in most health care settings. Developing a reliability-seeking culture requires leaders' sustained commitment to reliability principles using key mechanisms to embed those principles widely in the organization. The aim of this study was to examine how key mechanisms used by a primary care practice (PCP) might foster a reliability-seeking, system-oriented organizational culture. A case study approach was used to investigate the PCP's reliability culture. The study examined four cultural artifacts used to embed reliability-seeking principles across the organization: leadership statements, decision support tools, and two organizational processes. To decipher their effects on reliability, the study relied on observations of work patterns and the tools' use, interactions during morning huddles and process improvement meetings, interviews with clinical and office staff, and a "collective mindfulness" questionnaire. The five reliability principles framed the data analysis. Leadership statements articulated principles that oriented the PCP toward a reliability-seeking culture of care. Reliability principles became embedded in the everyday discourse and actions through the use of "problem knowledge coupler" decision support tools and daily "huddles." Practitioners and staff were encouraged to report unexpected events or close calls that arose and which often initiated a formal "process change" used to adjust routines and prevent adverse events from recurring. Activities that foster reliable patient care became part of the taken-for-granted routine at the PCP. The analysis illustrates the role leadership, tools, and organizational processes play in developing and embedding a reliable-seeking culture across an

  4. 76 FR 23171 - Electric Reliability Organization Interpretations of Interconnection Reliability Operations and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... ``Current Status of Bulk Electric Systems elements (transmission or generation including critical... Energy Regulatory Commission 18 CFR Part 40 Electric Reliability Organization Interpretations of... Federal Power Act, the Federal Energy Regulatory Commission hereby approves the North American...

  5. [Process design in high-reliability organizations].

    PubMed

    Sommer, K-J; Kranz, J; Steffens, J

    2014-05-01

    Modern medicine is a highly complex service industry in which individual care providers are linked in a complicated network. The complexity and interlinkedness is associated with risks concerning patient safety. Other highly complex industries like commercial aviation have succeeded in maintaining or even increasing its safety levels despite rapidly increasing passenger figures. Standard operating procedures (SOPs), crew resource management (CRM), as well as operational risk evaluation (ORE) are historically developed and trusted parts of a comprehensive and systemic safety program. If medicine wants to follow this quantum leap towards increased patient safety, it must intensively evaluate the results of other high-reliability industries and seek step-by-step implementation after a critical assessment.

  6. Classical Perturbation Theory for Monte Carlo Studies of System Reliability

    SciTech Connect

    Lewins, Jeffrey D.

    2001-03-15

    A variational principle for a Markov system allows the derivation of perturbation theory for models of system reliability, with prospects of extension to generalized Markov processes of a wide nature. It is envisaged that Monte Carlo or stochastic simulation will supply the trial functions for such a treatment, which obviates the standard difficulties of direct analog Monte Carlo perturbation studies. The development is given in the specific mode for first- and second-order theory, using an example with known analytical solutions. The adjoint equation is identified with the importance function and a discussion given as to how both the forward and backward (adjoint) fields can be obtained from a single Monte Carlo study, with similar interpretations for the additional functions required by second-order theory. Generalized Markov models with age-dependence are identified as coming into the scope of this perturbation theory.

  7. Theory and the organic bioethicist.

    PubMed

    Chambers, T

    2001-01-01

    This article argues for the importance of theoretical reflections that originate from patients' experiences. Traditionally academic philosophers have linked their ability to theorize about the moral basis of medical practice to their role as outside observer. The author contends that recently a new type of reflection has come from within particular patient populations. Drawing upon a distinction created by Antonio Gramsci, it is argued that one can distinguish the theory generated by traditional bioethicists, who are academically trained, from that of "organic" bioethicists, who identify themselves with a particular patient community. The characteristics of this new type of bioethicist that are explored in this article include a close association of memoir and philosophy, an interrelationship of theory and praxis, and an intimate connection between the individual and a particular patient community.

  8. Turkish validity and reliability of Organ Donation Attitude Scale.

    PubMed

    Yazici Sayin, Yazile

    2016-03-01

    To report the translation and adaptation process from English to Turkish and the psychometric estimates of the validity and reliability of The Organ Donation Attitude Scale Turkish. Its aim (1) is to provide data about and (2) to assess Turkish people's attitudes and volunteerism towards organ donation. Lack of donors is a significant problem for organ transplantation worldwide. Attitudes about organ donation and volunteerism are important factors in the lack of donors. To collect survey data from Turkish participants, a cross-sectional design was used: the classical measurement method. The Organ Donation Attitude Scale was translated from English to Turkish and back-translated into English. The analysis included a total of 892 Turkish participants. The validity of the scale was confirmed by exploratory factor analysis and criterion-relation validity testing. A test-retest procedure was implemented for the reliability of the scale over time. The Organ Donation Attitude Scale consists of three relatively independent components: humanity and moral conviction, fears of medical neglect and fears of bodily mutilation. Internal consistency of these three components resulted in acceptable Cronbach's α levels. Positive correlation occurred between the volunteerism score and positive attitude about organ donation. The correlation between volunteerism score and negative attitude about organ donation was negative. Fears of bodily mutilation were most significantly related to unwillingness to commit to organ donation. The test-retest correlation coefficients proves that the Organ Donation Attitude Scale were reliable over time. The Organ Donation Attitude Scale Turkish version is both a reliable and valid instrument that can be useful in measuring positive and negative attitudes of Turkish people about organ donation. With the Organ Donation Attitude Scale, researchers in Turkey will be able to ascertain important data on volunteerism and attitudes towards organ donation

  9. Studying Reliability of Open Ended Mathematics Items According to the Classical Test Theory and Generalizability Theory

    ERIC Educational Resources Information Center

    Guler, Nese; Gelbal, Selahattin

    2010-01-01

    In this study, the Classical test theory and generalizability theory were used for determination to reliability of scores obtained from measurement tool of mathematics success. 24 open-ended mathematics question of the TIMSS-1999 was applied to 203 students in 2007-spring semester. Internal consistency of scores was found as 0.92. For…

  10. Interrater reliability for Kernberg's structural interview for assessing personality organization.

    PubMed

    Ingenhoven, Theo J M; Duivenvoorden, Hugo J; Brogtrop, Janneke; Lindenborn, Anne; van den Brink, Wim; Passchier, Jan

    2009-10-01

    Interrater reliability is considered a precondition for the validity of theoretical models and their corresponding diagnostic instruments. Studies have documented good interrater reliability for structured interviews measuring personality characteristics on a descriptive-phenomenological level but there is little research on reliability of assessment procedures on a structural level. The current study investigated the interrater reliability of the structural interview (SI) designed to assess neurotic, borderline, and psychotic personality organization according to Kernberg. Videotaped SIs of 69 psychiatric patients were randomly and independently rated by two out of three trained psychologists. Agreement between rater pairs was expressed as square weighted kappa (K(sw), 95% CI). Results indicate satisfactory interrater reliability with respect to Kernberg's tripartite classification (K(sw) = 0.42, 95% CI 0.07 to 0.77). Subdivision of the borderline category or introduction of intermediate subcategories to the tripartite system did not significantly affect reliability (K(sw) = 0.55, 95% CI 0.30 to 0.80; K(sw) = 0.59, 95% CI 0.34 to 0.84, respectively). The conclusion is that trained clinicians can reliably assess structural personality organization using the SI. Refining the nosological system adding subcategories did not reduce reliability.

  11. How to Map Theory: Reliable Methods Are Fruitless Without Rigorous Theory.

    PubMed

    Gray, Kurt

    2017-08-01

    Good science requires both reliable methods and rigorous theory. Theory allows us to build a unified structure of knowledge, to connect the dots of individual studies and reveal the bigger picture. Some have criticized the proliferation of pet "Theories," but generic "theory" is essential to healthy science, because questions of theory are ultimately those of validity. Although reliable methods and rigorous theory are synergistic, Action Identification suggests psychological tension between them: The more we focus on methodological details, the less we notice the broader connections. Therefore, psychology needs to supplement training in methods (how to design studies and analyze data) with training in theory (how to connect studies and synthesize ideas). This article provides a technique for visually outlining theory: theory mapping. Theory mapping contains five elements, which are illustrated with moral judgment and with cars. Also included are 15 additional theory maps provided by experts in emotion, culture, priming, power, stress, ideology, morality, marketing, decision-making, and more (see all at theorymaps.org ). Theory mapping provides both precision and synthesis, which helps to resolve arguments, prevent redundancies, assess the theoretical contribution of papers, and evaluate the likelihood of surprising effects.

  12. The Stability and Reliability of a Modified Work Components Study Questionnaire in the Educational Organization.

    ERIC Educational Resources Information Center

    Miskel, Cecil; Heller, Leonard E.

    The investigation attempted to establish the factorial validity and reliability of an industrial selection device based on Herzberg's theory of work motivation related to the school organization. The questionnaire was reworded to reflect an educational work situation; and a random sample of 197 students, 118 administrators, and 432 teachers was…

  13. Modeling Sensor Reliability in Fault Diagnosis Based on Evidence Theory.

    PubMed

    Yuan, Kaijuan; Xiao, Fuyuan; Fei, Liguo; Kang, Bingyi; Deng, Yong

    2016-01-18

    Sensor data fusion plays an important role in fault diagnosis. Dempster-Shafer (D-R) evidence theory is widely used in fault diagnosis, since it is efficient to combine evidence from different sensors. However, under the situation where the evidence highly conflicts, it may obtain a counterintuitive result. To address the issue, a new method is proposed in this paper. Not only the statistic sensor reliability, but also the dynamic sensor reliability are taken into consideration. The evidence distance function and the belief entropy are combined to obtain the dynamic reliability of each sensor report. A weighted averaging method is adopted to modify the conflict evidence by assigning different weights to evidence according to sensor reliability. The proposed method has better performance in conflict management and fault diagnosis due to the fact that the information volume of each sensor report is taken into consideration. An application in fault diagnosis based on sensor fusion is illustrated to show the efficiency of the proposed method. The results show that the proposed method improves the accuracy of fault diagnosis from 81.19% to 89.48% compared to the existing methods.

  14. Modeling Sensor Reliability in Fault Diagnosis Based on Evidence Theory

    PubMed Central

    Yuan, Kaijuan; Xiao, Fuyuan; Fei, Liguo; Kang, Bingyi; Deng, Yong

    2016-01-01

    Sensor data fusion plays an important role in fault diagnosis. Dempster–Shafer (D-R) evidence theory is widely used in fault diagnosis, since it is efficient to combine evidence from different sensors. However, under the situation where the evidence highly conflicts, it may obtain a counterintuitive result. To address the issue, a new method is proposed in this paper. Not only the statistic sensor reliability, but also the dynamic sensor reliability are taken into consideration. The evidence distance function and the belief entropy are combined to obtain the dynamic reliability of each sensor report. A weighted averaging method is adopted to modify the conflict evidence by assigning different weights to evidence according to sensor reliability. The proposed method has better performance in conflict management and fault diagnosis due to the fact that the information volume of each sensor report is taken into consideration. An application in fault diagnosis based on sensor fusion is illustrated to show the efficiency of the proposed method. The results show that the proposed method improves the accuracy of fault diagnosis from 81.19% to 89.48% compared to the existing methods. PMID:26797611

  15. Teamwork as an Essential Component of High-Reliability Organizations

    PubMed Central

    Baker, David P; Day, Rachel; Salas, Eduardo

    2006-01-01

    Organizations are increasingly becoming dynamic and unstable. This evolution has given rise to greater reliance on teams and increased complexity in terms of team composition, skills required, and degree of risk involved. High-reliability organizations (HROs) are those that exist in such hazardous environments where the consequences of errors are high, but the occurrence of error is extremely low. In this article, we argue that teamwork is an essential component of achieving high reliability particularly in health care organizations. We describe the fundamental characteristics of teams, review strategies in team training, demonstrate the criticality of teamwork in HROs and finally, identify specific challenges the health care community must address to improve teamwork and enhance reliability. PMID:16898980

  16. Teamwork as an essential component of high-reliability organizations.

    PubMed

    Baker, David P; Day, Rachel; Salas, Eduardo

    2006-08-01

    Organizations are increasingly becoming dynamic and unstable. This evolution has given rise to greater reliance on teams and increased complexity in terms of team composition, skills required, and degree of risk involved. High-reliability organizations (HROs) are those that exist in such hazardous environments where the consequences of errors are high, but the occurrence of error is extremely low. In this article, we argue that teamwork is an essential component of achieving high reliability particularly in health care organizations. We describe the fundamental characteristics of teams, review strategies in team training, demonstrate the criticality of teamwork in HROs and finally, identify specific challenges the health care community must address to improve teamwork and enhance reliability.

  17. 76 FR 23222 - Electric Reliability Organization Interpretation of Transmission Operations Reliability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... effect on the human environment.\\22\\ The Commission has categorically excluded certain actions from this requirement as not having a significant effect on the human environment. Included in the exclusion are rules... Energy Regulatory Commission 18 CFR Part 40 Electric Reliability Organization Interpretation of...

  18. 76 FR 58101 - Electric Reliability Organization Interpretation of Transmission Operations Reliability Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... effect on the human environment.\\23\\ The Commission has categorically excluded certain actions from this requirement as not having a significant effect on the human environment. Included in the exclusion are rules... Federal Energy Regulatory Commission 18 CFR Part 40 Electric Reliability Organization Interpretation of...

  19. Generalizability Theory as a Unifying Framework of Measurement Reliability in Adolescent Research

    ERIC Educational Resources Information Center

    Fan, Xitao; Sun, Shaojing

    2014-01-01

    In adolescence research, the treatment of measurement reliability is often fragmented, and it is not always clear how different reliability coefficients are related. We show that generalizability theory (G-theory) is a comprehensive framework of measurement reliability, encompassing all other reliability methods (e.g., Pearson "r,"…

  20. Generalizability Theory as a Unifying Framework of Measurement Reliability in Adolescent Research

    ERIC Educational Resources Information Center

    Fan, Xitao; Sun, Shaojing

    2014-01-01

    In adolescence research, the treatment of measurement reliability is often fragmented, and it is not always clear how different reliability coefficients are related. We show that generalizability theory (G-theory) is a comprehensive framework of measurement reliability, encompassing all other reliability methods (e.g., Pearson "r,"…

  1. Putting "Organizations" into an Organization Theory Course: A Hybrid CAO Model for Teaching Organization Theory

    ERIC Educational Resources Information Center

    Hannah, David R.; Venkatachary, Ranga

    2010-01-01

    In this article, the authors present a retrospective analysis of an instructor's multiyear redesign of a course on organization theory into what is called a hybrid Classroom-as-Organization model. It is suggested that this new course design served to apprentice students to function in quasi-real organizational structures. The authors further argue…

  2. Putting "Organizations" into an Organization Theory Course: A Hybrid CAO Model for Teaching Organization Theory

    ERIC Educational Resources Information Center

    Hannah, David R.; Venkatachary, Ranga

    2010-01-01

    In this article, the authors present a retrospective analysis of an instructor's multiyear redesign of a course on organization theory into what is called a hybrid Classroom-as-Organization model. It is suggested that this new course design served to apprentice students to function in quasi-real organizational structures. The authors further argue…

  3. The Millennial Generation in High Reliability Organizations (HRO)

    DTIC Science & Technology

    2014-02-13

    Executives 2001, Vol 15. No 3 pp 70-79. 35 Weick , Karl , Sutcliffe, Kathleen, “Managing the Unexpected” Michigan Ross School of Business...Lessons from High Reliability Organizations; Academy of Management Executives 2001, Vol 15. No 3 pp 70-79. 39 Weick , Karl , Sutcliffe, Kathleen...26. Weick , Karl , Sutcliffe, Kathleen, “Managing the Unexpected” Michigan Ross School of Business, Presentation at Jacksonville FL Feb 2005. 27. Wolf

  4. Theory of reliable systems. [reliability analysis and on-line fault diagnosis

    NASA Technical Reports Server (NTRS)

    Meyer, J. F.

    1974-01-01

    Research is reported in the program to refine the current notion of system reliability by identifying and investigating attributes of a system which are important to reliability considerations, and to develop techniques which facilitate analysis of system reliability. Reliability analysis, and on-line fault diagnosis are discussed.

  5. Understanding High-Reliability Organizations: Are Baldrige Recipients Models?

    PubMed

    Griffith, John R

    2015-01-01

    Chassin and Loeb argue persuasively that healthcare organizations (HCOs) can and should be "high-reliability organizations" (HROs) seeking zero defects in outcomes quality. They suggest that the Baldrige model is a sound platform for achieving high reliability. This article analyzes the similarity of the HRO concept to the Baldrige model using a recent Malcolm Baldrige National Quality Award recipient's application. The analysis suggests that neither high reliability nor Baldrige criteria are easily achieved, but the two have strong similarities. The principal difference is in Baldrige's emphasis on strategic independence versus the HRO commitment to "zero patient harm" and quality as "the organization's highest-priority strategic goal." Based on this analysis, the article reviews data on the actual performance of Baldrige recipients as recorded at WhyNotTheBest.org. The data show that the Baldrige approach is an effective method of generating above-average performance. Award recipients have made substantial strides in safety, reductions of infections, immunizations, and patient satisfaction, but receipt of the award has not translated as effectively to reduced readmissions, mortality, and costs. The pattern of results suggests that Baldrige recipients have exploited the right to establish their own strategic goals and are likely to respond to strengthened financial rewards for quality. The Baldrige model has documented successes in quality improvement and should be the standard of excellence in managing all HCOs.

  6. Comparison of Reliability Measures under Factor Analysis and Item Response Theory

    ERIC Educational Resources Information Center

    Cheng, Ying; Yuan, Ke-Hai; Liu, Cheng

    2012-01-01

    Reliability of test scores is one of the most pervasive psychometric concepts in measurement. Reliability coefficients based on a unifactor model for continuous indicators include maximal reliability rho and an unweighted sum score-based omega, among many others. With increasing popularity of item response theory, a parallel reliability measure pi…

  7. Reliability theory for receptor-ligand bond dissociation

    NASA Astrophysics Data System (ADS)

    Tees, David F. J.; Woodward, John T.; Hammer, David A.

    2001-05-01

    Cell adhesion in the presence of hydrodynamic forces is a critical factor in inflammation, cancer metastasis, and blood clotting. A number of assays have recently been developed to apply forces to small numbers of the receptor-ligand bonds responsible for adhesion. Examples include assays using hydrodynamic shear in flow chambers or elastic probe deflection assays such as the atomic force microscope or the biomembrane force probe. One wishes to use the data on the time distribution of dissociation from these assays to derive information on the force dependence of reaction rates, an important determinant of cell adhesive behavior. The dissociation process can be described using the theory developed for reliability engineering of electronic components and networks. We use this framework along with the Bell model for the reverse reaction rate (kr=kr0exp[r0 f/kT], where f is the applied force and kr0 and r0 are Bell model parameters) to write closed form expressions for the probability distribution of break-up with multiple independent or interacting bonds. These expressions show that the average lifetime of n bonds scales with the nth harmonic number multiplied by the lifetime of a single bond. Results from calculation and simulations are used to describe the effect of experimental procedures in forced unbinding assays on the estimation of parameters for the force dependence of reverse reaction rates.

  8. Human Resource Management, Computers, and Organization Theory.

    ERIC Educational Resources Information Center

    Garson, G. David

    In an attempt to provide a framework for research and theory building in public management information systems (PMIS), state officials responsible for computing in personnel operations were surveyed. The data were applied to hypotheses arising from a recent model by Bozeman and Bretschneider, attempting to relate organization theory to management…

  9. Educational Management Organizations as High Reliability Organizations: A Study of Victory's Philadelphia High School Reform Work

    ERIC Educational Resources Information Center

    Thomas, David E.

    2013-01-01

    This executive position paper proposes recommendations for designing reform models between public and private sectors dedicated to improving school reform work in low performing urban high schools. It reviews scholarly research about for-profit educational management organizations, high reliability organizations, American high school reform, and…

  10. Educational Management Organizations as High Reliability Organizations: A Study of Victory's Philadelphia High School Reform Work

    ERIC Educational Resources Information Center

    Thomas, David E.

    2013-01-01

    This executive position paper proposes recommendations for designing reform models between public and private sectors dedicated to improving school reform work in low performing urban high schools. It reviews scholarly research about for-profit educational management organizations, high reliability organizations, American high school reform, and…

  11. Theory of reliable systems. [systems analysis and design

    NASA Technical Reports Server (NTRS)

    Meyer, J. F.

    1973-01-01

    The analysis and design of reliable systems are discussed. The attributes of system reliability studied are fault tolerance, diagnosability, and reconfigurability. Objectives of the study include: to determine properties of system structure that are conducive to a particular attribute; to determine methods for obtaining reliable realizations of a given system; and to determine how properties of system behavior relate to the complexity of fault tolerant realizations. A list of 34 references is included.

  12. Reliability correction for functional connectivity: Theory and implementation.

    PubMed

    Mueller, Sophia; Wang, Danhong; Fox, Michael D; Pan, Ruiqi; Lu, Jie; Li, Kuncheng; Sun, Wei; Buckner, Randy L; Liu, Hesheng

    2015-11-01

    Network properties can be estimated using functional connectivity MRI (fcMRI). However, regional variation of the fMRI signal causes systematic biases in network estimates including correlation attenuation in regions of low measurement reliability. Here we computed the spatial distribution of fcMRI reliability using longitudinal fcMRI datasets and demonstrated how pre-estimated reliability maps can correct for correlation attenuation. As a test case of reliability-based attenuation correction we estimated properties of the default network, where reliability was significantly lower than average in the medial temporal lobe and higher in the posterior medial cortex, heterogeneity that impacts estimation of the network. Accounting for this bias using attenuation correction revealed that the medial temporal lobe's contribution to the default network is typically underestimated. To render this approach useful to a greater number of datasets, we demonstrate that test-retest reliability maps derived from repeated runs within a single scanning session can be used as a surrogate for multi-session reliability mapping. Using data segments with different scan lengths between 1 and 30 min, we found that test-retest reliability of connectivity estimates increases with scan length while the spatial distribution of reliability is relatively stable even at short scan lengths. Finally, analyses of tertiary data revealed that reliability distribution is influenced by age, neuropsychiatric status and scanner type, suggesting that reliability correction may be especially important when studying between-group differences. Collectively, these results illustrate that reliability-based attenuation correction is an easily implemented strategy that mitigates certain features of fMRI signal nonuniformity.

  13. Conceptualizing Essay Tests' Reliability and Validity: From Research to Theory

    ERIC Educational Resources Information Center

    Badjadi, Nour El Imane

    2013-01-01

    The current paper on writing assessment surveys the literature on the reliability and validity of essay tests. The paper aims to examine the two concepts in relationship with essay testing as well as to provide a snapshot of the current understandings of the reliability and validity of essay tests as drawn in recent research studies. Bearing in…

  14. Tsallis statistics in reliability analysis: Theory and methods

    NASA Astrophysics Data System (ADS)

    Zhang, Fode; Shi, Yimin; Keung Tony Ng, Hon; Wang, Ruibing

    2016-10-01

    Tsallis statistics, which is based on a non-additive entropy characterized by an index q, is a very useful tool in physics and statistical mechanics. This paper presents an application of Tsallis statistics in reliability analysis. We first show that the q-gamma and incomplete q-gamma functions are q-generalized. Then, three commonly used statistical distributions in reliability analysis are introduced in Tsallis statistics, and the corresponding reliability characteristics including the reliability function, hazard function, cumulative hazard function and mean time to failure are investigated. In addition, we study the statistical inference based on censored reliability data. Specifically, we investigate the point and interval estimation of the model parameters of the q-exponential distribution based on the maximum likelihood method. Simulated and real-life datasets are used to illustrate the methodologies discussed in this paper. Finally, some concluding remarks are provided.

  15. 78 FR 38851 - Electric Reliability Organization Proposal To Retire Requirements in Reliability Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... requirements proposed for retirement either: Provide little protection for Bulk-Power System reliability or are... reliability of the Bulk-Power System. This proposal is part of the Commission's ongoing effort to review its... Bulk-Power System reliability or (2) are redundant with other aspects of the Reliability Standards.\\2...

  16. Reliability theory for diffusion processes on interconnected networks

    NASA Astrophysics Data System (ADS)

    Khorramzadeh, Yasamin; Youssef, Mina; Eubank, Stephen

    2014-03-01

    We present the concept of network reliability as a framework to study diffusion dynamics in interdependent networks. We illustrate how different outcomes of diffusion processes, such as cascading failure, can be studied by estimating the reliability polynomial under different reliability rules. As an example, we investigate the effect of structural properties on diffusion dynamics for a few different topologies of two coupled networks. We evaluate the effect of varying the probability of failure propagating along the edges, both within a single network as well as between the networks. We exhibit the sensitivity of interdependent network reliability and connectivity to edge failures in each topology. Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia 24061, USA.

  17. A Research of Weapon System Storage Reliability Simulation Method Based on Fuzzy Theory

    NASA Astrophysics Data System (ADS)

    Shi, Yonggang; Wu, Xuguang; Chen, Haijian; Xu, Tingxue

    Aimed at the problem of the new, complicated weapon equipment system storage reliability analyze, the paper researched on the methods of fuzzy fault tree analysis and fuzzy system storage reliability simulation, discussed the path that regarded weapon system as fuzzy system, and researched the storage reliability of weapon system based on fuzzy theory, provided a method of storage reliability research for the new, complicated weapon equipment system. As an example, built up the fuzzy fault tree of one type missile control instrument based on function analysis, and used the method of fuzzy system storage reliability simulation to analyze storage reliability index of control instrument.

  18. A PERSPECTIVE ON RELIABILITY: PROBABILITY THEORY AND BEYOND

    SciTech Connect

    J. M. BOOKER; N. D. SINGPURWALLA

    2001-05-01

    Reliability assessment in the coming era is inclined to be characterized by a difficult dilemma. On the one hand units and systems will be required to be ultra reliable; on the other hand, it may not be possible to subject them to a full-scale testing. A case in point occurs where testing is limited is one-of-a-kind complex systems, such as space exploration vehicles or where severe testing constraints are imposed such as full scale testing of strategic nuclear weapons prohibited by test ban treaties and international agreements. Decision makers also require reliability assessments for problems with terabytes of data, such as from complex simulations of system performance. Quantitative measures of reliability and their associated uncertainties will remain integral to system monitoring and tactical decision making. The challenge is to derive these defensible measures in light of these dilemmas. Because reliability is usually defined as a probability that the system performs to its required specification, probability enters into the heart of these dilemmas, both philosophically and practically. This paper provides an overview of the several interpretations of probability as they relate to reliability and to the uncertainties involved. The philosophical issues pertain to the interpretation and the quantification of reliability. For example, how must we interpret a number like 10{sup {minus}9}, for the failure rate of an airplane flight or an electrical power plant? Such numbers are common, particularly in the context of safety. Does it mean one failure in 10{sup 9} identical, or almost identical, trials? Are identical trials physically possible, let alone the fact that 10{sup 9} trials can take generations to perform? How can we make precise the notion of almost identical trials? If the trials are truly identical, then all of them must produce the same outcome and so the reliability must be either one or zero. However tautologies, like certainty and impossibility, can

  19. Test Theories, Educational Priorities and Reliability of Public Examinations in England

    ERIC Educational Resources Information Center

    Baird, Jo-Anne; Black, Paul

    2013-01-01

    Much has already been written on the controversies surrounding the use of different test theories in educational assessment. Other authors have noted the prevalence of classical test theory over item response theory in practice. This Special Issue draws together articles based upon work conducted on the Reliability Programme for England's…

  20. Using Metaphors to Teach Organization Theory

    ERIC Educational Resources Information Center

    Taber, Tom D.

    2007-01-01

    Metaphors were used to teach systems thinking and to clarify concepts of organizational theory in an introductory MBA management course. Gareth Morgan's metaphors of organization were read by students and applied as frames to analyze a business case. In addition, personal metaphors were written by individual students in order to describe the…

  1. Using Metaphors to Teach Organization Theory

    ERIC Educational Resources Information Center

    Taber, Tom D.

    2007-01-01

    Metaphors were used to teach systems thinking and to clarify concepts of organizational theory in an introductory MBA management course. Gareth Morgan's metaphors of organization were read by students and applied as frames to analyze a business case. In addition, personal metaphors were written by individual students in order to describe the…

  2. The Progress of Theory in Knowledge Organization.

    ERIC Educational Resources Information Center

    Smiraglia, Richard P.

    2002-01-01

    Presents a background on theory in knowledge organization, which has moved from an epistemic stance of pragmatism and rationalism (based on observation of the construction of retrieval tools), to empiricism (based on the results of empirical research). Discusses historicism, external validity, classification, user-interface design, and…

  3. The Progress of Theory in Knowledge Organization.

    ERIC Educational Resources Information Center

    Smiraglia, Richard P.

    2002-01-01

    Presents a background on theory in knowledge organization, which has moved from an epistemic stance of pragmatism and rationalism (based on observation of the construction of retrieval tools), to empiricism (based on the results of empirical research). Discusses historicism, external validity, classification, user-interface design, and…

  4. Understanding organic photovoltaic cells: Electrode, nanostructure, reliability, and performance

    NASA Astrophysics Data System (ADS)

    Kim, Myung-Su

    My Ph.D. research has focused on alternative renewable energy using organic semiconductors. During my study, first, I have established reliable characterization methods of organic photovoltaic devices. More specifically, less than 5% variation of power conversion efficiency of fabricated organic blend photovoltaic cells (OBPC) was achieved after optimization. The reproducibility of organic photovoltaic cell performance is one of the essential issues that must be clarified before beginning serious investigations of the application of creative and challenging ideas. Second, the relationships between fill factor (FF) and process variables have been demonstrated with series and shunt resistance, and this provided a chance to understand the electrical device behavior. In the blend layer, series resistance (Rs) and shunt resistance (Rsh) were varied by controlling the morphology of the blend layer, the regioregularity of the conjugated polymer, and the thickness of the blend layer. At the interface between the cathode including PEDOT:PSS and the blend layer, cathode conductivity was controlled by varying the structure of the cathode or adding an additive. Third, we thoroughly examined possible characterization mistakes in OPVC. One significant characterization mistake is observed when the crossbar electrode geometry of OPVC using PEDOT:PSS was fabricated and characterized with illumination which is larger than the actual device area. The hypothesis to explain this overestimation was excess photo-current generated from the cell region outside the overlapped electrode area, where PEDOT:PSS plays as anode and this was clearly supported with investigations. Finally, I incorporated a creative idea, which enhances the exciton dissociation efficiency by increasing the interface area between donor and acceptor to improve the power conversion efficiency of organic photovoltaic cells. To achieve this, nanoimprint lithography was applied for interface area increase. To clarify the

  5. The Fail-Safe Schools Challenge: Leadership Possibilities From High Reliability Organizations

    ERIC Educational Resources Information Center

    Bellamy, G.; Crawford, Lindy; Marshall, Laura; Coulter, Gail

    2005-01-01

    As public policies increasingly hold schools responsible for preventing school failure, experiences of other organizations that must operate with high reliability may be helpful. This article builds on previous studies of high reliability organizations to inquire how their strategies might inform efforts to improve reliability in loosely coupled…

  6. The Fail-Safe Schools Challenge: Leadership Possibilities from High Reliability Organizations. Perspective

    ERIC Educational Resources Information Center

    Bellamy, G. Thomas; Crawford, Lindy; Marshall, Laura Huber; Coulter, Gail A.

    2005-01-01

    As public policies increasingly hold schools responsible for preventing school failure, experiences of other organizations that must operate with high reliability may be helpful. This article builds on previous studies of high reliability organizations to inquire how their strategies might inform efforts to improve reliability in loosely coupled…

  7. 18 CFR 39.10 - Changes to an Electric Reliability Organization Rule or Regional Entity Rule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Reliability Organization Rule or Regional Entity Rule. 39.10 Section 39.10 Conservation of Power and Water... RULES CONCERNING CERTIFICATION OF THE ELECTRIC RELIABILITY ORGANIZATION; AND PROCEDURES FOR THE ESTABLISHMENT, APPROVAL, AND ENFORCEMENT OF ELECTRIC RELIABILITY STANDARDS § 39.10 Changes to an...

  8. Person Reliability in Personality Measurement: An Item Response Theory Analysis

    ERIC Educational Resources Information Center

    Ferrando, Pere J.

    2004-01-01

    This article discusses the rationale of an item response theory (IRT) model, based on Thurstone scaling, for personality measurement and suggests procedures for (a) estimating the location and slope parameters of the person response curve (PRC), (b) assessing the precision of the estimates, and (c) assessing the model-data fit. The relations…

  9. Bi-Factor Multidimensional Item Response Theory Modeling for Subscores Estimation, Reliability, and Classification

    ERIC Educational Resources Information Center

    Md Desa, Zairul Nor Deana

    2012-01-01

    In recent years, there has been increasing interest in estimating and improving subscore reliability. In this study, the multidimensional item response theory (MIRT) and the bi-factor model were combined to estimate subscores, to obtain subscores reliability, and subscores classification. Both the compensatory and partially compensatory MIRT…

  10. Organic magnetoresistance based on hopping theory

    NASA Astrophysics Data System (ADS)

    Yang, Fu-Jiang; Xie, Shi-Jie

    2014-09-01

    For the organic magnetoresistance (OMAR) effect, we suggest a spin-related hopping of carriers (polarons) based on Marcus theory. The mobility of polarons is calculated with the master equation (ME) and then the magnetoresistance (MR) is obtained. The theoretical results are consistent with the experimental observation. Especially, the sign inversion of the MR under different driving bias voltages found in the experiment is predicted. Besides, the effects of molecule disorder, hyperfine interaction (HFI), polaron localization, and temperature on the MR are investigated.

  11. 18 CFR 39.4 - Funding of the Electric Reliability Organization.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... business plan and organization chart, explaining the proposed collection of all dues, fees and charges and... Reliability Organization. 39.4 Section 39.4 Conservation of Power and Water Resources FEDERAL ENERGY... CERTIFICATION OF THE ELECTRIC RELIABILITY ORGANIZATION; AND PROCEDURES FOR THE ESTABLISHMENT, APPROVAL, AND...

  12. Theory of organic magnetoresistance in disordered organic semiconductors

    NASA Astrophysics Data System (ADS)

    Harmon, Nicholas J.; Flatté, Michael E.

    2012-10-01

    The understanding of spin transport in organics has been challenged by the discovery of large magnetic field effects on properties such as conductivity and electroluminescence in a wide array of organic systems. To explain the large organic magnetoresistance (OMAR) phenomenon, we present and solve a model for magnetoresistance in positionally disordered organic materials using percolation theory. The model describes the effects of singlettriplet spin transitions on hopping transport by considering the role of spin dynamics on an effective density of hopping sites. Faster spin transitions open up `spin-blocked' pathways to become viable conduction channels and hence produce magnetoresistance. We concentrate on spin transitions under the effects of the hyperfine (isotropic and anisotropic), exchange, and dipolar interactions. The magnetoresistance can be found analytically in several regimes and explains several experimental observations

  13. Reliability of the Measure of Acceptance of the Theory of Evolution (MATE) Instrument with University Students

    ERIC Educational Resources Information Center

    Rutledge, Michael L.; Sadler, Kim C.

    2007-01-01

    The Measure of Acceptance of the Theory of Evolution (MATE) instrument was initially designed to assess high school biology teachers' acceptance of evolutionary theory. To determine if the MATE instrument is reliable with university students, it was administered to students in a non-majors biology course (n = 61) twice over a 3-week period.…

  14. Reliability of the Measure of Acceptance of the Theory of Evolution (MATE) Instrument with University Students

    ERIC Educational Resources Information Center

    Rutledge, Michael L.; Sadler, Kim C.

    2007-01-01

    The Measure of Acceptance of the Theory of Evolution (MATE) instrument was initially designed to assess high school biology teachers' acceptance of evolutionary theory. To determine if the MATE instrument is reliable with university students, it was administered to students in a non-majors biology course (n = 61) twice over a 3-week period.…

  15. 78 FR 803 - Revisions to Electric Reliability Organization Definition of Bulk Electric System and Rules of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... to Electric Reliability Organization Definition of Bulk Electric System and Rules of Procedure; Final...; ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission 18 CFR Part 40 Revisions to Electric Reliability Organization Definition of Bulk Electric System and Rules of Procedure AGENCY: Federal Energy Regulatory...

  16. 78 FR 29209 - Revisions to Electric Reliability Organization Definition of Bulk Electric System and Rules of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... to Electric Reliability Organization Definition of Bulk Electric System and Rules of Procedure; Final...; ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission 18 CFR Part 40 Revisions to Electric Reliability Organization Definition of Bulk Electric System and Rules of Procedure AGENCY: Federal Energy Regulatory...

  17. 76 FR 16263 - Revision to Electric Reliability Organization Definition of Bulk Electric System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... Energy Regulatory Commission 18 CFR Part 40 Revision to Electric Reliability Organization Definition of Bulk Electric System AGENCY: Federal Energy Regulatory Commission, DOE. ACTION: Order on rehearing... Electric Reliability Organization (ERO) to revise the definition of the term ``bulk electric system...

  18. 75 FR 14097 - Revision to Electric Reliability Organization Definition of Bulk Electric System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ...; ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission 18 CFR Part 40 61,204] Revision to Electric Reliability Organization Definition of Bulk Electric System March 18, 2010. AGENCY: Federal Energy Regulatory... Electric Reliability Organization (ERO) to revise its definition of the term ``bulk electric system'' to...

  19. The application of high-reliability theory to promote pain management.

    PubMed

    Samuels, Joanne G

    2010-11-01

    Evidence-based pain management, a high-volume hospital service, impacts resource utilization and quality indicators. Despite extensive efforts to improve care, outcomes remain poor, and barriers seem insurmountable. Change management strategies that embrace organizational and individual accountabilities are warranted. Conceptualizing evidence-based pain management within the context of high-reliability theory may help redesign systems and processes to better meet needs of patients. The author discusses using a high-reliability framework as a change management strategy.

  20. Mathematic Modeling of Complex Hydraulic Machinery Systems When Evaluating Reliability Using Graph Theory

    NASA Astrophysics Data System (ADS)

    Zemenkova, M. Yu; Shipovalov, A. N.; Zemenkov, Yu D.

    2016-04-01

    The main technological equipment of pipeline transport of hydrocarbons are hydraulic machines. During transportation of oil mainly used of centrifugal pumps, designed to work in the “pumping station-pipeline” system. Composition of a standard pumping station consists of several pumps, complex hydraulic piping. The authors have developed a set of models and algorithms for calculating system reliability of pumps. It is based on the theory of reliability. As an example, considered one of the estimation methods with the application of graph theory.

  1. Development of the centralized reliability data organization (CREDO)

    SciTech Connect

    Bott, T. F.; Cunningham, G. W.; Greene, N. M.; Haas, P. M.; Hudson, S. D.; Knee, H. E.; Manning, J. J.

    1980-01-01

    The Centralized Reliability Data Organizaton (CREDO) has been established by the Reactor Research and Technology Division of the Department of Energy (RRT/DOE) at Oak Ridge National Laboratory (ORNL). It's primary functions are collection, evaluation and dissemination of reliability/availability data pertaining to advanced reactors. Associated information and analysis services will be provided to users. Interface and cooperative data exchange with existing US and international data banks is an integral part of CREDO's program plan. This paper outlines the design and operation of the proposed system and summarizes the status of its development. The schedule for developing CREDO has been lengthened as appropriate to the current schedule for development of advanced reactors in the US, but the initial development phase is nearing completion, and demonstration of system capabilities is anticipated prior to the end of FY 1980.

  2. Reliability analysis of the objective structured clinical examination using generalizability theory.

    PubMed

    Trejo-Mejía, Juan Andrés; Sánchez-Mendiola, Melchor; Méndez-Ramírez, Ignacio; Martínez-González, Adrián

    2016-01-01

    Background The objective structured clinical examination (OSCE) is a widely used method for assessing clinical competence in health sciences education. Studies using this method have shown evidence of validity and reliability. There are no published studies of OSCE reliability measurement with generalizability theory (G-theory) in Latin America. The aims of this study were to assess the reliability of an OSCE in medical students using G-theory and explore its usefulness for quality improvement. Methods An observational cross-sectional study was conducted at National Autonomous University of Mexico (UNAM) Faculty of Medicine in Mexico City. A total of 278 fifth-year medical students were assessed with an 18-station OSCE in a summative end-of-career final examination. There were four exam versions. G-theory with a crossover random effects design was used to identify the main sources of variance. Examiners, standardized patients, and cases were considered as a single facet of analysis. Results The exam was applied to 278 medical students. The OSCE had a generalizability coefficient of 0.93. The major components of variance were stations, students, and residual error. The sites and the versions of the tests had minimum variance. Conclusions Our study achieved a G coefficient similar to that found in other reports, which is acceptable for summative tests. G-theory allows the estimation of the magnitude of multiple sources of error and helps decision makers to determine the number of stations, test versions, and examiners needed to obtain reliable measurements.

  3. Reliability analysis of the objective structured clinical examination using generalizability theory

    PubMed Central

    Trejo-Mejía, Juan Andrés; Sánchez-Mendiola, Melchor; Méndez-Ramírez, Ignacio; Martínez-González, Adrián

    2016-01-01

    Background The objective structured clinical examination (OSCE) is a widely used method for assessing clinical competence in health sciences education. Studies using this method have shown evidence of validity and reliability. There are no published studies of OSCE reliability measurement with generalizability theory (G-theory) in Latin America. The aims of this study were to assess the reliability of an OSCE in medical students using G-theory and explore its usefulness for quality improvement. Methods An observational cross-sectional study was conducted at National Autonomous University of Mexico (UNAM) Faculty of Medicine in Mexico City. A total of 278 fifth-year medical students were assessed with an 18-station OSCE in a summative end-of-career final examination. There were four exam versions. G-theory with a crossover random effects design was used to identify the main sources of variance. Examiners, standardized patients, and cases were considered as a single facet of analysis. Results The exam was applied to 278 medical students. The OSCE had a generalizability coefficient of 0.93. The major components of variance were stations, students, and residual error. The sites and the versions of the tests had minimum variance. Conclusions Our study achieved a G coefficient similar to that found in other reports, which is acceptable for summative tests. G-theory allows the estimation of the magnitude of multiple sources of error and helps decision makers to determine the number of stations, test versions, and examiners needed to obtain reliable measurements. PMID:27543188

  4. Some Characteristics of One Type of High Reliability Organization.

    ERIC Educational Resources Information Center

    Roberts, Karlene H.

    1990-01-01

    Attempts to define organizational processes necessary to operate safely technologically complex organizations. Identifies nuclear powered aircraft carriers as examples of potentially hazardous organizations with histories of excellent operations. Discusses how carriers deal with components of risk and antecedents to catastrophe cited by Perrow and…

  5. Some Characteristics of One Type of High Reliability Organization.

    ERIC Educational Resources Information Center

    Roberts, Karlene H.

    1990-01-01

    Attempts to define organizational processes necessary to operate safely technologically complex organizations. Identifies nuclear powered aircraft carriers as examples of potentially hazardous organizations with histories of excellent operations. Discusses how carriers deal with components of risk and antecedents to catastrophe cited by Perrow and…

  6. Generalizability Theory Reliability of Written Expression Curriculum-Based Measurement in Universal Screening

    ERIC Educational Resources Information Center

    Keller-Margulis, Milena A.; Mercer, Sterett H.; Thomas, Erin L.

    2016-01-01

    The purpose of this study was to examine the reliability of written expression curriculum-based measurement (WE-CBM) in the context of universal screening from a generalizability theory framework. Students in second through fifth grade (n = 145) participated in the study. The sample included 54% female students, 49% White students, 23% African…

  7. Test Reliability and the Kuder-Richardson Formulas: Derivation from Probability Theory

    ERIC Educational Resources Information Center

    Zimmerman, Donald W.

    1972-01-01

    Although a great deal of attention has been devoted over a period of years to the estimation of reliability from item statistics, there are still gaps in the mathematical derivation of the Kuder-Richardson results. The main purpose of this paper is to fill some of these gaps, using language consistent with modern probability theory. (Author)

  8. Assessing Academic Advising Outcomes Using Social Cognitive Theory: A Validity and Reliability Study

    ERIC Educational Resources Information Center

    Erlich, Richard J.; Russ-Eft, Darlene F.

    2012-01-01

    The validity and reliability of three instruments, the "Counselor Rubric for Gauging Student Understanding of Academic Planning," micro-analytic questions, and the "Student Survey for Understanding Academic Planning," all based on social cognitive theory, were tested as means to assess self-efficacy and self-regulated learning in college academic…

  9. Estimating Reliability of School-Level Scores Using Multilevel and Generalizability Theory Models

    ERIC Educational Resources Information Center

    Jeon, Min-Jeong; Lee, Guemin; Hwang, Jeong-Won; Kang, Sang-Jin

    2009-01-01

    The purpose of this study was to investigate the methods of estimating the reliability of school-level scores using generalizability theory and multilevel models. Two approaches, "student within schools" and "students within schools and subject areas," were conceptualized and implemented in this study. Four methods resulting from the combination…

  10. Generalizability Theory Reliability of Written Expression Curriculum-Based Measurement in Universal Screening

    ERIC Educational Resources Information Center

    Keller-Margulis, Milena A.; Mercer, Sterett H.; Thomas, Erin L.

    2016-01-01

    The purpose of this study was to examine the reliability of written expression curriculum-based measurement (WE-CBM) in the context of universal screening from a generalizability theory framework. Students in second through fifth grade (n = 145) participated in the study. The sample included 54% female students, 49% White students, 23% African…

  11. Two Prophecy Formulas for Assessing the Reliability of Item Response Theory-Based Ability Estimates

    ERIC Educational Resources Information Center

    Raju, Nambury S.; Oshima, T.C.

    2005-01-01

    Two new prophecy formulas for estimating item response theory (IRT)-based reliability of a shortened or lengthened test are proposed. Some of the relationships between the two formulas, one of which is identical to the well-known Spearman-Brown prophecy formula, are examined and illustrated. The major assumptions underlying these formulas are…

  12. Assessing Academic Advising Outcomes Using Social Cognitive Theory: A Validity and Reliability Study

    ERIC Educational Resources Information Center

    Erlich, Richard J.; Russ-Eft, Darlene F.

    2012-01-01

    The validity and reliability of three instruments, the "Counselor Rubric for Gauging Student Understanding of Academic Planning," micro-analytic questions, and the "Student Survey for Understanding Academic Planning," all based on social cognitive theory, were tested as means to assess self-efficacy and self-regulated learning in college academic…

  13. Score Reliability of a Test Composed of Passage-Based Testlets: A Generalizability Theory Perspective.

    ERIC Educational Resources Information Center

    Lee, Yong-Won

    The purpose of this study was to investigate the impact of local item dependence (LID) in passage-based testlets on the test score reliability of an English as a Foreign Language (EFL) reading comprehension test from the perspective of generalizability (G) theory. Definitions and causes of LID in passage-based testlets are reviewed within the…

  14. Score Reliability of a Test Composed of Passage-Based Testlets: A Generalizability Theory Perspective.

    ERIC Educational Resources Information Center

    Lee, Yong-Won

    The purpose of this study was to investigate the impact of local item dependence (LID) in passage-based testlets on the test score reliability of an English as a Foreign Language (EFL) reading comprehension test from the perspective of generalizability (G) theory. Definitions and causes of LID in passage-based testlets are reviewed within the…

  15. Test-retest reliability of graph theory measures of structural brain connectivity.

    PubMed

    Dennis, Emily L; Jahanshad, Neda; Toga, Arthur W; McMahon, Katie L; de Zubicaray, Greig I; Martin, Nicholas G; Wright, Margaret J; Thompson, Paul M

    2012-01-01

    The human connectome has recently become a popular research topic in neuroscience, and many new algorithms have been applied to analyze brain networks. In particular, network topology measures from graph theory have been adapted to analyze network efficiency and 'small-world' properties. While there has been a surge in the number of papers examining connectivity through graph theory, questions remain about its test-retest reliability (TRT). In particular, the reproducibility of structural connectivity measures has not been assessed. We examined the TRT of global connectivity measures generated from graph theory analyses of 17 young adults who underwent two high-angular resolution diffusion (HARDI) scans approximately 3 months apart. Of the measures assessed, modularity had the highest TRT, and it was stable across a range of sparsities (a thresholding parameter used to define which network edges are retained). These reliability measures underline the need to develop network descriptors that are robust to acquisition parameters.

  16. 77 FR 59745 - Delegation of Authority Regarding Electric Reliability Organization's Budget, Delegation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... business plan and organization chart, and an explanation of the proposed collection of all dues, fees and... Organization's Budget, Delegation Agreement, and Policy and Procedure Filings AGENCY: Federal Energy Regulatory... responsibilities for specific Electric Reliability Organization (ERO) filings. In particular, this Final Rule...

  17. Leading Change: Transitioning the AFMS into a High Reliability Organization

    DTIC Science & Technology

    2016-02-16

    HROs recognize that expertise exists at all levels, from those who perform the everyday process to those in top management . Leadership creates...century, a major advancement of that time.13 Healthcare continues its quality improvement journey as it transforms into an HRO, where each customer ...because there are fewer formal levels of management . The traditional vertical structure of larger organizations contains numerous layers, making it

  18. Influencing Organizations to Promote Health: Applying Stakeholder Theory

    ERIC Educational Resources Information Center

    Kok, Gerjo; Gurabardhi, Zamira; Gottlieb, Nell H.; Zijlstra, Fred R. H.

    2015-01-01

    Stakeholder theory may help health promoters to make changes at the organizational and policy level to promote health. A stakeholder is any individual, group, or organization that can influence an organization. The organization that is the focus for influence attempts is called the focal organization. The more salient a stakeholder is and the more…

  19. Influencing Organizations to Promote Health: Applying Stakeholder Theory

    ERIC Educational Resources Information Center

    Kok, Gerjo; Gurabardhi, Zamira; Gottlieb, Nell H.; Zijlstra, Fred R. H.

    2015-01-01

    Stakeholder theory may help health promoters to make changes at the organizational and policy level to promote health. A stakeholder is any individual, group, or organization that can influence an organization. The organization that is the focus for influence attempts is called the focal organization. The more salient a stakeholder is and the more…

  20. Building New Bridges: Linking Organization Theory with Other Educational Literatures

    ERIC Educational Resources Information Center

    Johnson, Bob L., Jr.; Owens, Michael

    2005-01-01

    Purpose: This paper provides an example of how organization theory can be linked with other literatures in a complementary and productive manner. Establishing a bridge between the organization theory and learning environment literatures, the authors seek to provide an example of how such literature-bridging can enrich our understanding of the…

  1. Organizations or Communities? Changing the Metaphor Changes the Theory.

    ERIC Educational Resources Information Center

    Sergiovanni, Thomas J.

    Educational administration has been shaped by the metaphor of organization. From organizational and management theory, and from economics, the parent of organizational theory, educational administration has borrowed definitions of quality, productivity, and efficiency; strategies to achieve them; and theories of human nature and motivation.…

  2. In search of principles for a Theory of Organisms

    PubMed Central

    Longo, Giuseppe; Montévil, Maël; Sonnenschein, Carlos; Soto, Ana M

    2017-01-01

    Lacking an operational theory to explain the organization and behaviour of matter in unicellular and multicellular organisms hinders progress in biology. Such a theory should address life cycles from ontogenesis to death. This theory would complement the theory of evolution that addresses phylogenesis, and would posit theoretical extensions to accepted physical principles and default states in order to grasp the living state of matter and define proper biological observables. Thus, we favour adopting the default state implicit in Darwin’s theory, namely, cell proliferation with variation plus motility, and a framing principle, namely, life phenomena manifest themselves as non-identical iterations of morphogenetic processes. From this perspective, organisms become a consequence of the inherent variability generated by proliferation, motility and self-organization. Morphogenesis would then be the result of the default state plus physical constraints, like gravity, and those present in living organisms, like muscular tension. PMID:26648040

  3. In search of principles for a Theory of Organisms.

    PubMed

    Longo, Giuseppe; Montevil, Mael; Sonnenschein, Carlos; Soto, Ana M

    2015-12-01

    Lacking an operational theory to explain the organization and behaviour of matter in unicellular and multicellular organisms hinders progress in biology. Such a theory should address life cycles from ontogenesis to death. This theory would complement the theory of evolution that addresses phylogenesis, and would posit theoretical extensions to accepted physical principles and default states in order to grasp the living state of matter and define proper biological observables. Thus, we favour adopting the default state implicit in Darwin's theory, namely, cell proliferation with variation plus motility, and a framing principle, namely, life phenomena manifest themselves as non-identical iterations of morphogenetic processes. From this perspective, organisms become a consequence of the inherent variability generated by proliferation, motility and self-organization. Morphogenesis would then be the result of the default state plus physical constraints, like gravity, and those present in living organisms, like muscular tension.

  4. Sensor reliability evaluation scheme for target classification using belief function theory.

    PubMed

    Zhu, Jing; Luo, Yupin; Zhou, Jianjun

    2013-12-13

    In the target classification based on belief function theory, sensor reliability evaluation has two basic issues: reasonable dissimilarity measure among evidences, and adaptive combination of static and dynamic discounting. One solution to the two issues has been proposed here. Firstly, an improved dissimilarity measure based on dualistic exponential function has been designed. We assess the static reliability from a training set by the local decision of each sensor and the dissimilarity measure among evidences. The dynamic reliability factors are obtained from each test target using the dissimilarity measure between the output information of each sensor and the consensus. Secondly, an adaptive combination method of static and dynamic discounting has been introduced. We adopt Parzen-window to estimate the matching degree of current performance and static performance for the sensor. Through fuzzy theory, the fusion system can realize self-learning and self-adapting with the sensor performance changing. Experiments conducted on real databases demonstrate that our proposed scheme performs better in target classification under different target conditions compared with other methods.

  5. Sensor Reliability Evaluation Scheme for Target Classification Using Belief Function Theory

    PubMed Central

    Zhu, Jing; Luo, Yupin; Zhou, Jianjun

    2013-01-01

    In the target classification based on belief function theory, sensor reliability evaluation has two basic issues: reasonable dissimilarity measure among evidences, and adaptive combination of static and dynamic discounting. One solution to the two issues has been proposed here. Firstly, an improved dissimilarity measure based on dualistic exponential function has been designed. We assess the static reliability from a training set by the local decision of each sensor and the dissimilarity measure among evidences. The dynamic reliability factors are obtained from each test target using the dissimilarity measure between the output information of each sensor and the consensus. Secondly, an adaptive combination method of static and dynamic discounting has been introduced. We adopt Parzen-window to estimate the matching degree of current performance and static performance for the sensor. Through fuzzy theory, the fusion system can realize self-learning and self-adapting with the sensor performance changing. Experiments conducted on real databases demonstrate that our proposed scheme performs better in target classification under different target conditions compared with other methods. PMID:24351632

  6. Generalizability theory reliability of written expression curriculum-based measurement in universal screening.

    PubMed

    Keller-Margulis, Milena A; Mercer, Sterett H; Thomas, Erin L

    2016-09-01

    The purpose of this study was to examine the reliability of written expression curriculum-based measurement (WE-CBM) in the context of universal screening from a generalizability theory framework. Students in second through fifth grade (n = 145) participated in the study. The sample included 54% female students, 49% White students, 23% African American students, 17% Hispanic students, 8% Asian students, and 3% of students identified as 2 or more races. Of the sample, 8% were English Language Learners and 6% were students receiving special education. Three WE-CBM probes were administered for 7 min each at 3 time points across 1 year. Writing samples were scored for commonly used WE-CBM metrics (e.g., correct minus incorrect word sequences; CIWS). Results suggest that nearly half the variance in WE-CBM is related to unsystematic error and that conventional screening procedures (i.e., the use of one 3-min sample) do not yield scores with adequate reliability for relative or absolute decisions about student performance. In most grades, three 3-min writing samples (or 2 longer duration samples) were required for adequate reliability for relative decisions, and three 7-min writing samples would not yield adequate reliability for relative decisions about within-year student growth. Implications and recommendations are discussed. (PsycINFO Database Record

  7. [Reliability theory based on quality risk network analysis for Chinese medicine injection].

    PubMed

    Li, Zheng; Kang, Li-Yuan; Fan, Xiao-Hui

    2014-08-01

    A new risk analysis method based upon reliability theory was introduced in this paper for the quality risk management of Chinese medicine injection manufacturing plants. The risk events including both cause and effect ones were derived in the framework as nodes with a Bayesian network analysis approach. It thus transforms the risk analysis results from failure mode and effect analysis (FMEA) into a Bayesian network platform. With its structure and parameters determined, the network can be used to evaluate the system reliability quantitatively with probabilistic analytical appraoches. Using network analysis tools such as GeNie and AgenaRisk, we are able to find the nodes that are most critical to influence the system reliability. The importance of each node to the system can be quantitatively evaluated by calculating the effect of the node on the overall risk, and minimization plan can be determined accordingly to reduce their influences and improve the system reliability. Using the Shengmai injection manufacturing plant of SZYY Ltd as a user case, we analyzed the quality risk with both static FMEA analysis and dynamic Bayesian Network analysis. The potential risk factors for the quality of Shengmai injection manufacturing were identified with the network analysis platform. Quality assurance actions were further defined to reduce the risk and improve the product quality.

  8. Reliability and validity of advanced theory-of-mind measures in middle childhood and adolescence.

    PubMed

    Hayward, Elizabeth O; Homer, Bruce D

    2017-09-01

    Although theory-of-mind (ToM) development is well documented for early childhood, there is increasing research investigating changes in ToM reasoning in middle childhood and adolescence. However, the psychometric properties of most advanced ToM measures for use with older children and adolescents have not been firmly established. We report on the reliability and validity of widely used, conventional measures of advanced ToM with this age group. Notable issues with both reliability and validity of several of the measures were evident in the findings. With regard to construct validity, results do not reveal a clear empirical commonality between tasks, and, after accounting for comprehension, developmental trends were evident in only one of the tasks investigated. Statement of contribution What is already known on this subject? Second-order false belief tasks have acceptable internal consistency. The Eyes Test has poor internal consistency. Validity of advanced theory-of-mind tasks is often based on the ability to distinguish clinical from typical groups. What does this study add? This study examines internal consistency across six widely used advanced theory-of-mind tasks. It investigates validity of tasks based on comprehension of items by typically developing individuals. It further assesses construct validity, or commonality between tasks. © 2017 The British Psychological Society.

  9. A Systems Theory View of Organizations as Communication Networks.

    ERIC Educational Resources Information Center

    Schwartz, Donald F.

    Focusing on the analysis of communication networks within organizations with an eye toward implications for study of external communication, this paper (1) develops a systems theory/communication view of the nature of formal organizations, (2) illustrates the notion of holistic organizational communication networks in organizations which include…

  10. Free Radical Timer of Aging: from Chemistry of Free Radicals to Systems Theory of Reliability.

    PubMed

    Koltover, Vitaly K

    2017-01-01

    There are two generally known concepts in biology of aging. Accordingly to the first one, there is a program of aging. The alternative concept advocates that aging proceeds stochastically. In this area of research, free radical-theory of aging, which was put forward by Denham Harman in fifties of XXth century, has determined the most heuristic line. The goal of this review is to demonstrate how the aging program and the aging stochastics are united on the basis of the systems theory of reliability. On this basis, universal features of aging, such as the exponential growth of mortality rate with time and correlation of longevity with the species-specific resting metabolism, are naturally explained. The stochastic malfunctions of the mitochondrial electron transport nanoreactors, which produce the oxygen anion-radicals (O2•-) as by-products of respiration, seem to be of first importance. As a reducing agent, O2•- affects the ratio of NAD(P)H/NAD(P)+ and, by changing the activity of sirtuins, slows down renewal of biomolecular constructs. As a consequence, the oxidative-stress products and other metabolic slag accumulate with the resulting impetus to autophagic or apoptotic cell death accompanied with age-associated clinical disorders. Based on this reliability-theory approach, one can estimate that the longevity of human brain could reach 250 years should the antioxidant defense against the free-radical failures be perfect. Thus, the free-radical redox timer serves as effective stochastic mechanism of realization of the programmed deficiency in reliability of biomolecular constructs.

  11. Central Perspectives and Debates in Organization Theory.

    ERIC Educational Resources Information Center

    Astley, W. Graham; Van de Ven, Andrew H.

    1983-01-01

    Classifies organizational theories, by analytical level and assumptions about human nature, into four perspectives (system-structural, strategic choice, natural selection, collective action), each with different concepts of organizational structure, behavior, change, and managerial roles. Identifies six debates generated among the perspectives and…

  12. Central Perspectives and Debates in Organization Theory.

    ERIC Educational Resources Information Center

    Astley, W. Graham; Van de Ven, Andrew H.

    1983-01-01

    Classifies organizational theories, by analytical level and assumptions about human nature, into four perspectives (system-structural, strategic choice, natural selection, collective action), each with different concepts of organizational structure, behavior, change, and managerial roles. Identifies six debates generated among the perspectives and…

  13. A Novel Evaluation Method for Building Construction Project Based on Integrated Information Entropy with Reliability Theory

    PubMed Central

    Bai, Xiao-ping; Zhang, Xi-wei

    2013-01-01

    Selecting construction schemes of the building engineering project is a complex multiobjective optimization decision process, in which many indexes need to be selected to find the optimum scheme. Aiming at this problem, this paper selects cost, progress, quality, and safety as the four first-order evaluation indexes, uses the quantitative method for the cost index, uses integrated qualitative and quantitative methodologies for progress, quality, and safety indexes, and integrates engineering economics, reliability theories, and information entropy theory to present a new evaluation method for building construction project. Combined with a practical case, this paper also presents detailed computing processes and steps, including selecting all order indexes, establishing the index matrix, computing score values of all order indexes, computing the synthesis score, sorting all selected schemes, and making analysis and decision. Presented method can offer valuable references for risk computing of building construction projects. PMID:23533352

  14. A novel evaluation method for building construction project based on integrated information entropy with reliability theory.

    PubMed

    Bai, Xiao-ping; Zhang, Xi-wei

    2013-01-01

    Selecting construction schemes of the building engineering project is a complex multiobjective optimization decision process, in which many indexes need to be selected to find the optimum scheme. Aiming at this problem, this paper selects cost, progress, quality, and safety as the four first-order evaluation indexes, uses the quantitative method for the cost index, uses integrated qualitative and quantitative methodologies for progress, quality, and safety indexes, and integrates engineering economics, reliability theories, and information entropy theory to present a new evaluation method for building construction project. Combined with a practical case, this paper also presents detailed computing processes and steps, including selecting all order indexes, establishing the index matrix, computing score values of all order indexes, computing the synthesis score, sorting all selected schemes, and making analysis and decision. Presented method can offer valuable references for risk computing of building construction projects.

  15. Organizations and Social Systems: Organization Theory's Neglected Mandate.

    ERIC Educational Resources Information Center

    Stern, Robert N.; Barley, Stephen R.

    1996-01-01

    The social-systems perspective in organizational theory faded because the increasing complexity of social relations hindered determination of an appropriate unit of analysis. Also, the business-school environment in which organizational research occurred discouraged examination of broad social questions, promoted a particular approach to science,…

  16. Organizations and Social Systems: Organization Theory's Neglected Mandate.

    ERIC Educational Resources Information Center

    Stern, Robert N.; Barley, Stephen R.

    1996-01-01

    The social-systems perspective in organizational theory faded because the increasing complexity of social relations hindered determination of an appropriate unit of analysis. Also, the business-school environment in which organizational research occurred discouraged examination of broad social questions, promoted a particular approach to science,…

  17. Research on High Reliability Organizations: Implications for School Effects Research, Policy, and Educational Practice.

    ERIC Educational Resources Information Center

    Stringfield, Sam

    Current theorizing in education, as in industry, is largely devoted to explaining trial-and-error, failure-tolerant, low-reliability organizations. This article examines changing societal demands on education and argues that effective responses to those demands require new and different organizational structures. Schools must abandon industrial…

  18. [Employees in high-reliability organizations: systematic selection of personnel as a final criterion].

    PubMed

    Oubaid, V; Anheuser, P

    2014-05-01

    Employees represent an important safety factor in high-reliability organizations. The combination of clear organizational structures, a nonpunitive safety culture, and psychological personnel selection guarantee a high level of safety. The cockpit personnel selection process of a major German airline is presented in order to demonstrate a possible transferability into medicine and urology.

  19. 18 CFR 39.4 - Funding of the Electric Reliability Organization.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Reliability Organization. 39.4 Section 39.4 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT RULES CONCERNING... interruption as it transitions from one method of funding to another. Any proposed transitional funding...

  20. High reliability organizing implementation at Sequoia and Kings Canyon National Parks

    Treesearch

    David A. Christenson; Mike DeGrosky; Anne E. Black; Brett Fay

    2008-01-01

    It is said that action often precedes cognition. For example, wildland fire management personnel already do things in the course of their work that they will later recognize as consistent with the principles of high reliability organizing (HRO), once they know about those principles. In the case of Sequoia and Kings Canyon National Parks (SEKI), the fire management...

  1. Influencing organizations to promote health: applying stakeholder theory.

    PubMed

    Kok, Gerjo; Gurabardhi, Zamira; Gottlieb, Nell H; Zijlstra, Fred R H

    2015-04-01

    Stakeholder theory may help health promoters to make changes at the organizational and policy level to promote health. A stakeholder is any individual, group, or organization that can influence an organization. The organization that is the focus for influence attempts is called the focal organization. The more salient a stakeholder is and the more central in the network, the stronger the influence. As stakeholders, health promoters may use communicative, compromise, deinstitutionalization, or coercive methods through an ally or a coalition. A hypothetical case study, involving adolescent use of harmful legal products, illustrates the process of applying stakeholder theory to strategic decision making.

  2. Using Generalizability Theory To Estimate the Reliability of Writing Scores Derived from Holistic and Analytical Scoring Methods.

    ERIC Educational Resources Information Center

    Swartz, Carl W.; Hooper, Stephen R.; Mongomery, James W.; Wakely, Melissa B.; De Kruif, Renee E. L.; Reed, Martha; Brown, Timothy T.; Levine, Melvin D.; White, Kinnard P.

    1999-01-01

    Used generalizability theory to investigate the impact of the number of raters and the type of decision (relative versus absolute) on the reliability of writing scores. Results from 251 middle school students and 20 intermediate grade students show that reliability coefficients decline as the number of raters declines and when absolute decisions…

  3. Understanding Schools as High-Reliability Organizations: An Exploratory Examination of Teachers' and School Leaders' Perceptions of Success

    ERIC Educational Resources Information Center

    Lorton, Juli A.; Bellamy, G. Thomas; Reece, Anne; Carlson, Jill

    2013-01-01

    Drawing on research on high-reliability organizations, this interviewbased qualitative case study employs four characteristics of such organizations as a lens for analyzing the operations of one very successful K-5 public school. Results suggest that the school had processes similar to those characteristic of high-reliability organizations: a…

  4. Understanding Schools as High-Reliability Organizations: An Exploratory Examination of Teachers' and School Leaders' Perceptions of Success

    ERIC Educational Resources Information Center

    Lorton, Juli A.; Bellamy, G. Thomas; Reece, Anne; Carlson, Jill

    2013-01-01

    Drawing on research on high-reliability organizations, this interviewbased qualitative case study employs four characteristics of such organizations as a lens for analyzing the operations of one very successful K-5 public school. Results suggest that the school had processes similar to those characteristic of high-reliability organizations: a…

  5. General Systems Theory Approaches to Organizations: Some Problems in Application

    ERIC Educational Resources Information Center

    Peery, Newman S., Jr.

    1975-01-01

    Considers the limitations of General Systems Theory (GST) as a major paradigm within administrative theory and concludes that most systems formulations overemphasize growth and show little appreciation for intraorganizational conflict, diversity of values, and political action within organizations. Suggests that these limitations are mainly due to…

  6. Ab-Initio Theory of Charge Transport in Organic Crystals

    NASA Astrophysics Data System (ADS)

    Hannewald, K.; Bobbert, P. A.

    2005-06-01

    A theory of charge transport in organic crystals is presented. Using a Holstein-Peierls model, an explicit expression for the charge-carrier mobilities as a function of temperature is obtained. Calculating all material parameters from ab initio calculations, the theory is applied to oligo-acene crystals and a brief comparison to experiment is given.

  7. Photothermal radiometry parametric identifiability theory for reliable and unique nondestructive coating thickness and thermophysical measurements

    NASA Astrophysics Data System (ADS)

    Guo, X.; Mandelis, A.; Tolev, J.; Tang, K.

    2017-03-01

    In this paper, we present a detailed reliability analysis of estimated parameters to a three-layer theoretical model of photothermal radiometry frequency domain signals by applying parameter identifiability conditions from two steel samples coated with ˜10 μm and 20 μm thick ceramic coating, to measure the thermophysical parameters of the coating, such as thermal diffusivity, thermal conductivity, and coating thickness. The three parameters are unique only when their sensitivity coefficients are linearly independent over the range of measurements. The study demonstrates the complexity of the identifiable experimental conditions through identifiability maps (calculated nonidentifiable locations) and sensitivity coefficient plots, even when the three separated parameters are grouped into two parameters. The validation of the reliability analysis theory by comparing the independently measured, with the fitted thicknesses of two coatings under random and optimized conditions, underscore the great importance of identifiability analysis (sensitivity coefficient plots) in the design of experiments for reliable parameter extractions, especially when the number of parameters is greater than the measurement data channels.

  8. Using the Reliability Theory for Assessing the Decision Confidence Probability for Comparative Life Cycle Assessments.

    PubMed

    Wei, Wei; Larrey-Lassalle, Pyrène; Faure, Thierry; Dumoulin, Nicolas; Roux, Philippe; Mathias, Jean-Denis

    2016-03-01

    Comparative decision making process is widely used to identify which option (system, product, service, etc.) has smaller environmental footprints and for providing recommendations that help stakeholders take future decisions. However, the uncertainty problem complicates the comparison and the decision making. Probability-based decision support in LCA is a way to help stakeholders in their decision-making process. It calculates the decision confidence probability which expresses the probability of a option to have a smaller environmental impact than the one of another option. Here we apply the reliability theory to approximate the decision confidence probability. We compare the traditional Monte Carlo method with a reliability method called FORM method. The Monte Carlo method needs high computational time to calculate the decision confidence probability. The FORM method enables us to approximate the decision confidence probability with fewer simulations than the Monte Carlo method by approximating the response surface. Moreover, the FORM method calculates the associated importance factors that correspond to a sensitivity analysis in relation to the probability. The importance factors allow stakeholders to determine which factors influence their decision. Our results clearly show that the reliability method provides additional useful information to stakeholders as well as it reduces the computational time.

  9. Theory and modeling of stereoselective organic reactions.

    PubMed

    Houk, K N; Paddon-Row, M N; Rondan, N G; Wu, Y D; Brown, F K; Spellmeyer, D C; Metz, J T; Li, Y; Loncharich, R J

    1986-03-07

    Theoretical investigations of the transition structures of additions and cycloadditions reveal details about the geometries of bond-forming processes that are not directly accessible by experiment. The conformational analysis of transition states has been developed from theoretical generalizations about the preferred angle of attack by reagents on multiple bonds and predictions of conformations with respect to partially formed bonds. Qualitative rules for the prediction of the stereochemistries of organic reactions have been devised, and semi-empirical computational models have also been developed to predict the stereoselectivities of reactions of large organic molecules, such as nucleophilic additions to carbonyls, electrophilic hydroborations and cycloadditions, and intramolecular radical additions and cycloadditions.

  10. Development of a Valid and Reliable Questionnaire to Identify Professional Opinion Regarding Organ Transplantation System

    PubMed Central

    Sah, B.; Ayer, A.; Yadav, B. N.; Jha, S.; Yadav, S. K.

    2017-01-01

    Background: Currently, the Nepalese law permits organ donation by an individual who falls into the category of a “close relative” of the recipient. There is a need for expansion of the live organ donor pool beside close relatives. Different systems of organ transplantation are followed by several countries and the professional opinions that underpin these systems need to be studied. Objective: To generate a questionnaire related to different organ transplant systems and validate it so that it can be used to collect mass professional opinions. Methods: Item generation, item reduction, item scaling, and pretesting were used to develop a questionnaire. The final version of the questionnaire was reviewed by experts for its content validity and then was used twice for participants at a 20-day interval to calculate Cronbach’s alpha for testing its internal consistency and Intra-class correlation for testing its test and retest reliability. Results: The questionnaire was found to be valid and reliable with an overall Cronbach’s alpha of 0.701. Intra-class correlation scores for each question in both test and retest were correlated. Conclusion: A valid and reliable questionnaire was developed that can be used to collect mass professional opinions to assist policy makers to establish a better organ transplant system. PMID:28924463

  11. The Organization of the Living: A Theory of the Living Organization

    ERIC Educational Resources Information Center

    Maturana, H. R.

    1975-01-01

    Article presents a theory of the organization of living systems as autonomous entities, and a theory of the organization of the nervous system as a closed network of interacting neurons structurally coupled to the living system to whose realization it contributes. (Author)

  12. Theory and modeling of stereoselective organic reactions

    SciTech Connect

    Houk, K.N.; Paddon-Row, M.N.; Rondan, N.G.; Wu, Y.D.; Brown, F.K.; Spellmeyer, D.C.; Metz, J.T.; Li, Y.; Loncharich, R.J.

    1986-03-07

    Theoretical investigations of the transition structures of additions and cycloadditions reveal details about the geometrics of bond-forming processes that are not directly accessible by experiment. The conformational analysis of transition states has been developed from theoretical generalizations about the preferred angle of attack by reagents on multiple bonds and predictions of conformations with respect to partially formed bonds. Qualitative rules for the prediction of the stereochemistries of organic reactions have been devised, and semi-empirical computational models have also been developed to predict the stereoselectivities of reactions of large organic molecules, such as nucleophilic additions to carbonyls, electrophilic hydroborations and cycloadditions, and intramolecular radical additions and cycloadditions. 52 references, 7 figures.

  13. Prolegomena to a Theory of Organization

    DTIC Science & Technology

    1951-12-10

    of loyalty, the " espirit de corps," corruption, the fact that ~~me leadersof organizations seem to be able to obtain a greater effect than others...such as a cartel, labor union , etc., the cost-profit principle is immediately seen to be in grave jeopardy. We shall return to this below. But f1rst...the first case; the difficulties some highly concentrated European econo- mies have encountered may be illustrations for the second case. However

  14. Hospital-based fall program measurement and improvement in high reliability organizations.

    PubMed

    Quigley, Patricia A; White, Susan V

    2013-05-31

    Falls and fall injuries in hospitals are the most frequently reported adverse event among adults in the inpatient setting. Advancing measurement and improvement around falls prevention in the hospital is important as falls are a nurse sensitive measure and nurses play a key role in this component of patient care. A framework for applying the concepts of high reliability organizations to falls prevention programs is described, including discussion of the core characteristics of such a model and determining the impact at the patient, unit, and organizational level. This article showcases the components of a patient safety culture and the integration of these components with fall prevention, the role of nurses, and high reliability.

  15. Patient safety in anesthesia: learning from the culture of high-reliability organizations.

    PubMed

    Wright, Suzanne M

    2015-03-01

    There has been an increased awareness of and interest in patient safety and improved outcomes, as well as a growing body of evidence substantiating medical error as a leading cause of death and injury in the United States. According to The Joint Commission, US hospitals demonstrate improvements in health care quality and patient safety. Although this progress is encouraging, much room for improvement remains. High-reliability organizations, industries that deliver reliable performances in the face of complex working environments, can serve as models of safety for our health care system until plausible explanations for patient harm are better understood. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Teaching Organization Theory and Practice: An Experiential and Reflective Approach

    ERIC Educational Resources Information Center

    Cameron, Mark; Turkiewicz, Rita M.; Holdaway, Britt A.; Bill, Jacqueline S.; Goodman, Jessica; Bonner, Aisha; Daly, Stacey; Cohen, Michael D.; Lorenz, Cassandra; Wilson, Paul R.; Rusk, James

    2009-01-01

    The organization is often the overlooked level in social work's ecological perspective. However, organizational realities exert a profound influence on human development and well-being as well as the nature and quality of social work practice. This article describes a model of teaching organization theory and practice which requires master's…

  17. Teaching Organization Theory and Practice: An Experiential and Reflective Approach

    ERIC Educational Resources Information Center

    Cameron, Mark; Turkiewicz, Rita M.; Holdaway, Britt A.; Bill, Jacqueline S.; Goodman, Jessica; Bonner, Aisha; Daly, Stacey; Cohen, Michael D.; Lorenz, Cassandra; Wilson, Paul R.; Rusk, James

    2009-01-01

    The organization is often the overlooked level in social work's ecological perspective. However, organizational realities exert a profound influence on human development and well-being as well as the nature and quality of social work practice. This article describes a model of teaching organization theory and practice which requires master's…

  18. Do Advance Organizers Facilitate Learning? A Review of Subsumption Theory.

    ERIC Educational Resources Information Center

    McEneany, John E.

    1990-01-01

    A review of four studies conducted by Ausubel raises serious doubts about the efficacy of advance organizers under a variety of circumstances. In addition, this review questions the adequacy of definitions for two central notions of subsumption theory (discriminability and advance organizer). (IAH)

  19. Do Advance Organizers Facilitate Learning? A Review of Subsumption Theory.

    ERIC Educational Resources Information Center

    McEneany, John E.

    1990-01-01

    A review of four studies conducted by Ausubel raises serious doubts about the efficacy of advance organizers under a variety of circumstances. In addition, this review questions the adequacy of definitions for two central notions of subsumption theory (discriminability and advance organizer). (IAH)

  20. Enhance the lifetime and bias stress reliability in organic vertical transistor by UV/Ozone treatment

    NASA Astrophysics Data System (ADS)

    Lin, Hung-Cheng; Chang, Ming-Yu; Zan, Hsiao-Wen; Meng, Hsin-Fei; Chao, Yu-Chiang

    In this paper, we use UV/Ozone treatment to improve the lifetime and bias stress reliability of organic transistor with vertical channel. Even if vertical organic transistor exhibits better bias stress reliability than organic field effect transistor (OFET) due to bulk conduction mechanism, poor lifetime performance is still a challenge. Adding octadecyltrichlorosilane (OTS) to treat the vertical channel can reduce the trapping state and hence improve the bias stress ability. However, off-current is much higher after 6 days and lifetime performance is degraded. On the other hand, after 4000-s on-state bias stress, stable output current and on/off current ratio are demonstrated by using UV/Ozone to treat vertical channels. Threshold voltage shift is only -0.02 V which is much smaller than OFET with the same organic semiconductor material. Furthermore, the output current is also an order enhanced. Nevertheless, unlike device with OTS treatment, no obvious degradation is observed for UV/Ozone treated devices even after 170 days. With UV/Ozone treatment, the output current, bias stress reliability and lifetime were all improved. It makes vertical transistor become a promising device for the further application in display technology and flexible electronics.

  1. Cliophysics: socio-political reliability theory, polity duration and African political (in)stabilities.

    PubMed

    Cherif, Alhaji; Barley, Kamal

    2010-12-29

    Quantification of historical sociological processes have recently gained attention among theoreticians in the effort of providing a solid theoretical understanding of the behaviors and regularities present in socio-political dynamics. Here we present a reliability theory of polity processes with emphases on individual political dynamics of African countries. We found that the structural properties of polity failure rates successfully capture the risk of political vulnerability and instabilities in which , , , and of the countries with monotonically increasing, unimodal, U-shaped and monotonically decreasing polity failure rates, respectively, have high level of state fragility indices. The quasi-U-shape relationship between average polity duration and regime types corroborates historical precedents and explains the stability of the autocracies and democracies.

  2. Cliophysics: Socio-Political Reliability Theory, Polity Duration and African Political (In)stabilities

    PubMed Central

    Cherif, Alhaji; Barley, Kamal

    2010-01-01

    Quantification of historical sociological processes have recently gained attention among theoreticians in the effort of providing a solid theoretical understanding of the behaviors and regularities present in socio-political dynamics. Here we present a reliability theory of polity processes with emphases on individual political dynamics of African countries. We found that the structural properties of polity failure rates successfully capture the risk of political vulnerability and instabilities in which , , , and of the countries with monotonically increasing, unimodal, U-shaped and monotonically decreasing polity failure rates, respectively, have high level of state fragility indices. The quasi-U-shape relationship between average polity duration and regime types corroborates historical precedents and explains the stability of the autocracies and democracies. PMID:21206911

  3. The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory

    PubMed Central

    Soto, Ana M.; Sonnenschein, Carlos

    2014-01-01

    The somatic mutation theory (SMT) of cancer has been and remains the prevalent theory attempting to explain how neoplasms arise and progress. This theory proposes that cancer is a clonal, cell-based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms. The SMT has not been rigorously tested, and several lines of evidence raise questions that are not addressed by this theory. Herein, we propose experimental strategies that may validate the SMT. We also call attention to an alternative theory of carcinogenesis, the tissue organization field theory (TOFT), which posits that cancer is a tissue-based disease and that proliferation is the default state of all cells. Based on epistemological and experimental evidence, we argue that the TOFT compellingly explains carcinogenesis, while placing it within an evolutionarily relevant context. PMID:21503935

  4. Test-retest reliability of the Sensory Organization Test in older persons with a transtibial amputation.

    PubMed

    Jayakaran, Prasath; Johnson, Gillian M; Sullivan, S John

    2011-08-01

    To determine the test-retest reliability of the Sensory Organization Test (SOT) in older persons with a unilateral transtibial amputation. Cross-sectional observational study with repeated measures. A University balance laboratory. Fifteen participants (12 men and 3 women) who had undergone a unilateral transtibial amputation that was performed as a result of either trauma or complications of diabetes or peripheral vascular disease were recruited from a patient database. The mean age of the participants was 69.53 years (SD, 6.60), with 11.94 mean years of prosthetic use. All participants completed 3 trials of the 6 balance testing conditions in the standard SOT protocol with use of the NeuroCom SMART Equitest system on 2 occasions approximately 2 weeks apart. Reliability of the mean equilibrium and strategy scores for the 6 SOT conditions and the overall composite score was evaluated using intraclass correlation coefficients. The test-retest reliability coefficients (intraclass correlation coefficient model 2,1) for the equilibrium scores ranged from 0.67-0.90 for conditions 1 to 4 and 6, indicating fair-to-good reliability. The coefficients obtained for the strategy scores of all the conditions and the composite score showed excellent reliability (intraclass correlation coefficients >0.75). This study suggests that the majority of outcome measurements associated with the SOT protocol on the SMART Equitest provide a reliable measure of dynamic balance performance in older persons with a unilateral transtibial amputation, even in the presence of comorbidities. The equilibrium, strategy, and composite scores obtained from the testing protocol with the exception of condition 5, can be used reliably in clinical practice to monitor for changes in balance with rehabilitation or to monitor the effects of a specific intervention and/or in patients with comorbidities that could potentially affect their balance capacities. Copyright © 2011 American Academy of Physical

  5. Carcinogenesis explained within the context of a theory of organisms

    PubMed Central

    Sonnenschein, Carlos; Soto, Ana

    2017-01-01

    For a century, the somatic mutation theory (SMT) has been the prevalent theory to explain carcinogenesis. According to the SMT, cancer is a cellular problem, and thus, the level of organization where it should be studied is the cellular level. Additionally, the SMT proposes that cancer is a problem of the control of cell proliferation and assumes that proliferative quiescence is the default state of cells in metazoa. In 1999, a competing theory, the tissue organization field theory (TOFT), was proposed. In contraposition to the SMT, the TOFT posits that cancer is a tissue-based disease whereby carcinogens (directly) and mutations in the germ-line (indirectly) alter the normal interactions between the diverse components of an organ, such as the stroma and its adjacent epithelium. The TOFT explicitly acknowledges that the default state of all cells is proliferation with variation and motility. When taking into consideration the principle of organization, we posit that carcinogenesis can be explained as a relational problem whereby release of the constraints created by cell interactions and the physical forces generated by cellular agency lead cells within a tissue to regain their default state of proliferation with variation and motility. Within this perspective, what matters both in morphogenesis and carcinogenesis is not only molecules, but also biophysical forces generated by cells and tissues. Herein, we describe how the principles for a theory of organisms apply to the TOFT and thus to the study of carcinogenesis. PMID:27498170

  6. Carcinogenesis explained within the context of a theory of organisms.

    PubMed

    Sonnenschein, Carlos; Soto, Ana M

    2016-10-01

    For a century, the somatic mutation theory (SMT) has been the prevalent theory to explain carcinogenesis. According to the SMT, cancer is a cellular problem, and thus, the level of organization where it should be studied is the cellular level. Additionally, the SMT proposes that cancer is a problem of the control of cell proliferation and assumes that proliferative quiescence is the default state of cells in metazoa. In 1999, a competing theory, the tissue organization field theory (TOFT), was proposed. In contraposition to the SMT, the TOFT posits that cancer is a tissue-based disease whereby carcinogens (directly) and mutations in the germ-line (indirectly) alter the normal interactions between the diverse components of an organ, such as the stroma and its adjacent epithelium. The TOFT explicitly acknowledges that the default state of all cells is proliferation with variation and motility. When taking into consideration the principle of organization, we posit that carcinogenesis can be explained as a relational problem whereby release of the constraints created by cell interactions and the physical forces generated by cellular agency lead cells within a tissue to regain their default state of proliferation with variation and motility. Within this perspective, what matters both in morphogenesis and carcinogenesis is not only molecules, but also biophysical forces generated by cells and tissues. Herein, we describe how the principles for a theory of organisms apply to the TOFT and thus to the study of carcinogenesis.

  7. A Challenge to Traditional Theory: Critical Race Theory, African-American Community Organizers, and Education

    ERIC Educational Resources Information Center

    Stovall, David

    2005-01-01

    The following article, through the tenets of critical race theory, seeks to investigate the relationship between theory and practice in school-community relationships. By investigating the views, values, and perceptions of three African-American community organizers in Chicago, Illinois, the following account offers a "challenge" to traditional…

  8. Cross Cultural Perspectives of the Learning Organization: Assessing the Validity and Reliability of the DLOQ in Korea

    ERIC Educational Resources Information Center

    Song, Ji Hoon; Kim, Jin Yong; Chermack, Thomas J.; Yang; Baiyin

    2008-01-01

    The primary purpose of this research was to adapt the Dimensions of Learning Organization Questionnaire (DLOQ) from Watkins and Marsick (1993, 1996) and examine its validity and reliability in a Korean context. Results indicate that the DLOQ produces valid and reliable scores of learning organization characteristics in a Korean cultural context.…

  9. Reliability and Validity of the Computerized Dynamic Posturography Sensory Organization Test in People with Multiple Sclerosis

    PubMed Central

    Manago, Mark M.

    2017-01-01

    Background: People with multiple sclerosis (MS) frequently have impaired postural control (balance). Psychometric properties of clinical tests of balance for individuals with MS, including the computerized dynamic posturography sensory organization test (CDP-SOT), are poorly understood. This study aimed to determine the reliability and discriminant validity of the CDP-SOT in people with MS. Methods: The CDP-SOT was performed on 30 participants with MS. A 2-week–interval, repeated-measures (sessions 1 and 2) design was implemented to investigate test-retest reliability of the CDP-SOT and the ability of the CDP-SOT to discriminate between participants with lower versus higher disability. Self-reported disability level was based on Patient-Determined Disease Steps (PDDS) scale scores: lower (PDDS scale score, 0–3; n = 17) and higher (PDDS scale score, 4–6; n = 13). Results: All six conditions of the CDP-SOT had good-to-excellent reliability (interclass correlation coefficients, 0.70–0.90) and excellent reliability for composite scores (0.90). Composite scores were significantly greater in the lower-disability group versus the higher-disability group at session 1 (70.89 vs. 48.60, P = .001) and session 2 (74.82 vs. 48.85, P = .002). Conclusions: The CDP-SOT is a reliable measure of balance and accurately differentiates disability status in people with MS. Collectively, the results support clinical application of the CDP-SOT as a reliable and valid measure of disease-related progression of impaired balance related to sensory integration and its utility in determining changes in balance in response to treatment. PMID:28603464

  10. Identifying Health Maintenance Organization membership through self-report of health plan name: ascertainment and reliability.

    PubMed

    Clements, Karen M; Cohen, Bruce B; Brawarsky, Phyllis; Brooks, Daniel R; Mucci, Lorelei A; Wood, Phillip A

    2006-01-01

    To evaluate the feasibility and reliability of (1) identifying Health Maintenance Organization (HMO) membership by ascertaining self-reported health plan name in a telephone survey and (2) using external information to determine whether the plan was an HMO. Respondents to the 1999-2001 Massachusetts Behavioral Risk Factor Surveillance System (BRFSS) and the 1999 Massachusetts Colorectal Cancer (CRC) survey were asked to name their health plan. The authors used information from external sources to classify the plan as an HMO or a non-HMO. Test-retest reliability of reported plan name was examined overall, by demographic characteristics, and by health plan name. Reliability of HMO classification was tested with the kappa statistic. More than 88 percent of respondents with commercial health insurance provided their health plan name; 84 percent reported a plan that could be assigned as either an HMO or a non-HMO. The percentage whose HMO status could be assigned differed by demographic characteristics. Among those assigned, the distribution of specific HMOs among survey respondents was similar to the distribution reported by the Massachusetts Division of Insurance. In a subsample, 78 percent reported the same health plan during a follow-up interview. Agreement was higher for men, and differed according to the plan reported at the first time point. Kappa for HMO classification from health plan name was 0.87. Self-report of health plan name is a feasible and reliable method to ascertain health insurance information in a telephone interview.

  11. Validity and reliability on three European language versions of the Safety Organizing Scale.

    PubMed

    Ausserhofer, Dietmar; Schubert, Maria; Blegen, Mary; De Geest, Sabina; Schwendimann, René

    2013-04-01

    The Safety Organizing Scale (SOS) offers a reliable snapshot of nurses' engagement in unit-level safety behaviors in hospitals. As no comparable questionnaire exists in German, French and Italian, we explored the psychometric properties of SOS translations into each of those languages. The psychometric properties of the nine-item SOS were tested according to American Educational Research Association guidelines. Between October 2009 and June 2010, 1633 registered medical and/or surgical nurses in 35 Swiss hospitals completed translated SOS questionnaires. For each translation, psychometric evaluation revealed evidence based on content (scale-content validity index >0.89), response patterns (e.g. average of missing values across all items = 0.80%), internal structure (e.g. comparative fit indices >0.90, root mean square error of approximation <0.08) and reliability (Cronbach's alpha >0.79). We differentiated the scale regarding one related concept (implicit rationing of nursing care). Higher SOS scores correlated with supportive leadership and lower nurse-reported medication errors, but not with nurse-reported patient falls. The SOS offers a valuable measurement of engagement in safety practices that might influence patient outcomes. Initial evidence regarding the validity and reliability of the translated versions supports their use in German, French and Italian. Concurrent validity will require confirmation via further analysis using more reliable outcome measures (e.g. mortality rates). The translated versions' predictive validity needs to be established in prospective studies.

  12. Measuring theory of mind across middle childhood: Reliability and validity of the Silent Films and Strange Stories tasks.

    PubMed

    Devine, Rory T; Hughes, Claire

    2016-09-01

    Recent years have seen a growth of research on the development of children's ability to reason about others' mental states (or "theory of mind") beyond the narrow confines of the preschool period. The overall aim of this study was to investigate the psychometric properties of a task battery composed of items from Happé's Strange Stories task and Devine and Hughes' Silent Film task. A sample of 460 ethnically and socially diverse children (211 boys) between 7 and 13years of age completed the task battery at two time points separated by 1month. The Strange Stories and Silent Film tasks were strongly correlated even when verbal ability and narrative comprehension were taken into account, and all items loaded onto a single theory-of-mind latent factor. The theory-of-mind latent factor provided reliable estimates of performance across a wide range of theory-of-mind ability and showed no evidence of differential item functioning across gender, ethnicity, or socioeconomic status. The theory-of-mind latent factor also exhibited strong 1-month test-retest reliability, and this stability did not vary as a function of child characteristics. Taken together, these findings provide evidence for the validity and reliability of the Strange Stories and Silent Film task battery as a measure of individual differences in theory of mind suitable for use across middle childhood. We consider the methodological and conceptual implications of these findings for research on theory of mind beyond the preschool years.

  13. A win for HROs. Employing high-reliability organization characteristics in EMS.

    PubMed

    Heightman, A J

    2013-06-01

    Was I insubordinate, arrogant or disrespectful? You may feel that I was. But in reality, I was educated to a level that could have been validated and should have been respected by command. I was, in fact, practicing a key aspect of HRO. I was stopping an obvious dangerous condition before it could harm or kill emergency responders. My IC colleague knew it from the facts presented and, in fact, joked with me about my "subtle sarcasm" and moved the perimeter to the recommended half-mile distance. Did I win, or did a proactive HRO win? Actually, HRO won and potentially saved 30 lives. I simply presented the hazards of CFC inhalation. A high-reliability organization must not rely on only one source of data when detailed information on a hazard isn't immediately available, or if it isn't very informative during an emergency decision-making process. Read "EMS & High Reliability Organizing: Achieving safety & reliability in the dynamic, high-risk environment and practice its important principles," pp. 60-63. It's really common sense, not rocket science, and may save you, your crews or others in your community.

  14. Are We Hoping For A Bounce A Study On Resilience And Human Relations In A High Reliability Organization

    DTIC Science & Technology

    2016-03-01

    A BOUNCE? A STUDY ON RESILIENCE AND HUMAN RELATIONS IN A HIGH RELIABILITY ORGANIZATION by Robert D. Johns March 2016 Thesis Advisor...March 2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE ARE WE HOPING FOR A BOUNCE? A STUDY ON RESILIENCE AND HUMAN ...RELATIONS IN A HIGH RELIABILITY ORGANIZATION 5. FUNDING NUMBERS 6. AUTHOR(S) Robert D. Johns 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES

  15. A modelling approach to find stable and reliable soil organic carbon values for further regionalization.

    NASA Astrophysics Data System (ADS)

    Bönecke, Eric; Franko, Uwe

    2015-04-01

    Soil organic matter (SOM) and carbon (SOC) might be the most important components to describe soil fertility of agricultural used soils. It is sensitive to temporal and spatial changes due to varying weather conditions, uneven crops and soil management practices and still struggles with providing reliable delineation of spatial variability. Soil organic carbon, furthermore, is an essential initial parameter for dynamic modelling, understanding e.g. carbon and nitrogen processes. Alas it requires cost and time intensive field and laboratory work to attain and using this information. The objective of this study is to assess an approach that reduces efforts of laboratory and field analyses by using method to find stable initial soil organic carbon values for further soil process modelling and regionalization on field scale. The demand of strategies, technics and tools to improve reliable soil organic carbon high resolution maps and additionally reducing cost constraints is hence still facing an increasing attention of scientific research. Although, it is nowadays a widely used practice, combining effective sampling schemes with geophysical sensing techniques, to describe within-field variability of soil organic carbon, it is still challenging large uncertainties, even at field scale in both, science and agriculture. Therefore, an analytical and modelling approach might facilitate and improve this strategy on small and large field scale. This study will show a method, how to find reliable steady state values of soil organic carbon at particular points, using the approved soil process model CANDY (Franko et al. 1995). It is focusing on an iterative algorithm of adjusting the key driving components: soil physical properties, meteorological data and management information, for which we quantified the input and the losses of soil carbon (manure, crop residues, other organic inputs, decomposition, leaching). Furthermore, this approach can be combined with geophysical

  16. Reliability-based robust design optimization of vehicle components, Part I: Theory

    NASA Astrophysics Data System (ADS)

    Zhang, Yimin

    2015-06-01

    The reliability-based design optimization, the reliability sensitivity analysis and robust design method are employed to present a practical and effective approach for reliability-based robust design optimization of vehicle components. A procedure for reliability-based robust design optimization of vehicle components is proposed. Application of the method is illustrated by reliability-based robust design optimization of axle and spring. Numerical results have shown that the proposed method can be trusted to perform reliability-based robust design optimization of vehicle components.

  17. Reliability and validity of the German version of the Structured Interview of Personality Organization (STIPO)

    PubMed Central

    2013-01-01

    Background The assessment of personality organization and its observable behavioral manifestations, i.e. personality functioning, has a long tradition in psychodynamic psychiatry. Recently, the DSM-5 Levels of Personality Functioning Scale has moved it into the focus of psychiatric diagnostics. Based on Kernberg’s concept of personality organization the Structured Interview of Personality Organization (STIPO) was developed for diagnosing personality functioning. The STIPO covers seven dimensions: (1) identity, (2) object relations, (3) primitive defenses, (4) coping/rigidity, (5) aggression, (6) moral values, and (7) reality testing and perceptual distortions. The English version of the STIPO has previously revealed satisfying psychometric properties. Methods Validity and reliability of the German version of the 100-item instrument have been evaluated in 122 psychiatric patients. All patients were diagnosed according to the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV) and were assessed by means of the STIPO. Moreover, all patients completed eight questionnaires that served as criteria for external validity of the STIPO. Results Interrater reliability varied between intraclass correlations of .89 and 1.0, Crohnbach’s α for the seven dimensions was .69 to .93. All a priori selected questionnaire scales correlated significantly with the corresponding STIPO dimensions. Patients with personality disorder (PD) revealed significantly higher STIPO scores (i.e. worse personality functioning) than patients without PD; patients cluster B PD showed significantly higher STIPO scores than patients with cluster C PD. Conclusions Interrater reliability, Crohnbach’s α, concurrent validity, and differential validity of the STIPO are satisfying. The STIPO represents an appropriate instrument for the assessment of personality functioning in clinical and research settings. PMID:23941404

  18. A Critique of Raju and Oshima's Prophecy Formulas for Assessing the Reliability of Item Response Theory-Based Ability Estimates

    ERIC Educational Resources Information Center

    Wang, Wen-Chung

    2008-01-01

    Raju and Oshima (2005) proposed two prophecy formulas based on item response theory in order to predict the reliability of ability estimates for a test after change in its length. The first prophecy formula is equivalent to the classical Spearman-Brown prophecy formula. The second prophecy formula is misleading because of an underlying false…

  19. The Development of the Functional Literacy Experience Scale Based upon Ecological Theory (FLESBUET) and Validity-Reliability Study

    ERIC Educational Resources Information Center

    Özenç, Emine Gül; Dogan, M. Cihangir

    2014-01-01

    This study aims to perform a validity-reliability test by developing the Functional Literacy Experience Scale based upon Ecological Theory (FLESBUET) for primary education students. The study group includes 209 fifth grade students at Sabri Taskin Primary School in the Kartal District of Istanbul, Turkey during the 2010-2011 academic year.…

  20. Organic unity theory: the mind-body problem revisited.

    PubMed

    Goodman, A

    1991-05-01

    The purpose of this essay is to delineate the conceptual framework for psychiatry as an integrated and integrative science that unites the mental and the physical. Four basic philosophical perspectives concerning the relationship between mind and body are introduced. The biopsychosocial model, at this time the preeminent model in medical science that addresses this relationship, is examined and found to be flawed. Mental-physical identity theory is presented as the most valid philosophical approach to understanding the relationship between mind and body. Organic unity theory is then proposed as a synthesis of the biopsychosocial model and mental-physical identity theory in which the difficulties of the biopsychosocial model are resolved. Finally, some implications of organic unity theory for psychiatry are considered. 1) The conventional dichotomy between physical (organic) and mental (functional) is linguistic/conceptual rather than inherent in nature, and all events and processes involved in the etiology, pathogenesis, symptomatic manifestation, and treatment of psychiatric disorders are simultaneously biological and psychological. 2) Neuroscience requires new conceptual models to comprehend the integrated and emergent physiological processes to which psychological phenomena correspond. 3) Introspective awareness provides data that are valid for scientific inquiry and is the most direct method of knowing psychophysical events. 4) Energy currently being expended in disputes between biological and psychological psychiatry would be more productively invested in attempting to formulate the conditions under which each approach is maximally effective.

  1. Using G-Theory to Enhance Evidence of Reliability and Validity for Common Uses of the Paulhus Deception Scales.

    PubMed

    Vispoel, Walter P; Morris, Carrie A; Kilinc, Murat

    2016-04-13

    We applied a new approach to Generalizability theory (G-theory) involving parallel splits and repeated measures to evaluate common uses of the Paulhus Deception Scales based on polytomous and four types of dichotomous scoring. G-theory indices of reliability and validity accounting for specific-factor, transient, and random-response measurement error supported use of polytomous over dichotomous scores as contamination checks; as control, explanatory, and outcome variables; as aspects of construct validation; and as indexes of environmental effects on socially desirable responding. Polytomous scoring also provided results for flagging faking as dependable as those when using dichotomous scoring methods. These findings argue strongly against the nearly exclusive use of dichotomous scoring for the Paulhus Deception Scales in practice and underscore the value of G-theory in demonstrating this. We provide guidelines for applying our G-theory techniques to other objectively scored clinical assessments, for using G-theory to estimate how changes to a measure might improve reliability, and for obtaining software to conduct G-theory analyses free of charge.

  2. Using multivariate generalizability theory to assess the effect of content stratification on the reliability of a performance assessment.

    PubMed

    Keller, Lisa A; Clauser, Brian E; Swanson, David B

    2010-12-01

    In recent years, demand for performance assessments has continued to grow. However, performance assessments are notorious for lower reliability, and in particular, low reliability resulting from task specificity. Since reliability analyses typically treat the performance tasks as randomly sampled from an infinite universe of tasks, these estimates of reliability may not be accurate. For tests built according to a table of specifications, tasks are randomly sampled from different strata (content domains, skill areas, etc.). If these strata remain fixed in the test construction process, ignoring this stratification in the reliability analysis results in an underestimate of "parallel forms" reliability, and an overestimate of the person-by-task component. This research explores the effect of representing and misrepresenting the stratification appropriately in estimation of reliability and the standard error of measurement. Both multivariate and univariate generalizability studies are reported. Results indicate that the proper specification of the analytic design is essential in yielding the proper information both about the generalizability of the assessment and the standard error of measurement. Further, illustrative D studies present the effect under a variety of situations and test designs. Additional benefits of multivariate generalizability theory in test design and evaluation are also discussed.

  3. Theory for spin diffusion in disordered organic semiconductors.

    PubMed

    Bobbert, P A; Wagemans, W; van Oost, F W A; Koopmans, B; Wohlgenannt, M

    2009-04-17

    We present a theory for spin diffusion in disordered organic semiconductors, based on incoherent hopping of a charge carrier and coherent precession of its spin in an effective magnetic field, composed of the random hyperfine field of hydrogen nuclei and an applied magnetic field. From Monte Carlo simulations and an analysis of the waiting-time distribution of the carrier we predict a surprisingly weak temperature dependence, but a considerable magnetic-field dependence of the spin-diffusion length. We show that both predictions are in agreement with experiments on organic spin valves.

  4. Theory for Spin Diffusion in Disordered Organic Semiconductors

    NASA Astrophysics Data System (ADS)

    Bobbert, P. A.; Wagemans, W.; van Oost, F. W. A.; Koopmans, B.; Wohlgenannt, M.

    2009-04-01

    We present a theory for spin diffusion in disordered organic semiconductors, based on incoherent hopping of a charge carrier and coherent precession of its spin in an effective magnetic field, composed of the random hyperfine field of hydrogen nuclei and an applied magnetic field. From Monte Carlo simulations and an analysis of the waiting-time distribution of the carrier we predict a surprisingly weak temperature dependence, but a considerable magnetic-field dependence of the spin-diffusion length. We show that both predictions are in agreement with experiments on organic spin valves.

  5. Organization Theory, Political Theory, and the International Arena: Some Hope But Very Little Time.

    ERIC Educational Resources Information Center

    Thayer, Frederick C.

    This paper presents background on a non-hierarchical organizational perspective. In addition, it presents guidelines for using a non-hierarchical perspective to create generally acceptable forms of international organizations. The theory on which the non-hierarchical perspective is based maintains that a form of comprehensive global planning…

  6. Organization Theory, Political Theory, and the International Arena: Some Hope But Very Little Time.

    ERIC Educational Resources Information Center

    Thayer, Frederick C.

    This paper presents background on a non-hierarchical organizational perspective. In addition, it presents guidelines for using a non-hierarchical perspective to create generally acceptable forms of international organizations. The theory on which the non-hierarchical perspective is based maintains that a form of comprehensive global planning…

  7. Organic unity theory: an integrative mind-body theory for psychiatry.

    PubMed

    Goodman, A

    1997-12-01

    The potential of psychiatry as an integrative science has been impeded by an internal schism that derives from the duality of mental and physical. Organic unity theory is proposed as a conceptual framework that brings together the terms of the mind-body duality in one coherent perspective. Organic unity theory is braided of three strands: identity, which describes the relationship between mentally described events and corresponding physically described events; continuity, which describes the linguistic-conceptual system that contains both mental and physical terms; and dialectic, which describes the relationship between the empirical way of knowing that is associated with the physical domain of the linguistic-conceptual system and the hermeneutic way of knowing that is associated with the mental domain. Each strand represents an integrative formulation that resolves an aspect of mental-physical dualism into an underlying unity. After the theory is presented, its implications for psychiatry are briefly considered.

  8. Validity and Reliability of Published Comprehensive Theory of Mind Tests for Normal Preschool Children: A Systematic Review

    PubMed Central

    Ziatabar Ahmadi, Seyyede Zohreh; Jalaie, Shohreh; Ashayeri, Hassan

    2015-01-01

    Objective: Theory of mind (ToM) or mindreading is an aspect of social cognition that evaluates mental states and beliefs of oneself and others. Validity and reliability are very important criteria when evaluating standard tests; and without them, these tests are not usable. The aim of this study was to systematically review the validity and reliability of published English comprehensive ToM tests developed for normal preschool children. Method: We searched MEDLINE (PubMed interface), Web of Science, Science direct, PsycINFO, and also evidence base Medicine (The Cochrane Library) databases from 1990 to June 2015. Search strategy was Latin transcription of ‘Theory of Mind’ AND test AND children. Also, we manually studied the reference lists of all final searched articles and carried out a search of their references. Inclusion criteria were as follows: Valid and reliable diagnostic ToM tests published from 1990 to June 2015 for normal preschool children; and exclusion criteria were as follows: the studies that only used ToM tests and single tasks (false belief tasks) for ToM assessment and/or had no description about structure, validity or reliability of their tests. Methodological quality of the selected articles was assessed using the Critical Appraisal Skills Programme (CASP). Result: In primary searching, we found 1237 articles in total databases. After removing duplicates and applying all inclusion and exclusion criteria, we selected 11 tests for this systematic review. Conclusion: There were a few valid, reliable and comprehensive ToM tests for normal preschool children. However, we had limitations concerning the included articles. The defined ToM tests were different in populations, tasks, mode of presentations, scoring, mode of responses, times and other variables. Also, they had various validities and reliabilities. Therefore, it is recommended that the researchers and clinicians select the ToM tests according to their psychometric characteristics

  9. Validity and Reliability of Published Comprehensive Theory of Mind Tests for Normal Preschool Children: A Systematic Review.

    PubMed

    Ziatabar Ahmadi, Seyyede Zohreh; Jalaie, Shohreh; Ashayeri, Hassan

    2015-09-01

    Theory of mind (ToM) or mindreading is an aspect of social cognition that evaluates mental states and beliefs of oneself and others. Validity and reliability are very important criteria when evaluating standard tests; and without them, these tests are not usable. The aim of this study was to systematically review the validity and reliability of published English comprehensive ToM tests developed for normal preschool children. We searched MEDLINE (PubMed interface), Web of Science, Science direct, PsycINFO, and also evidence base Medicine (The Cochrane Library) databases from 1990 to June 2015. Search strategy was Latin transcription of 'Theory of Mind' AND test AND children. Also, we manually studied the reference lists of all final searched articles and carried out a search of their references. Inclusion criteria were as follows: Valid and reliable diagnostic ToM tests published from 1990 to June 2015 for normal preschool children; and exclusion criteria were as follows: the studies that only used ToM tests and single tasks (false belief tasks) for ToM assessment and/or had no description about structure, validity or reliability of their tests. METHODological quality of the selected articles was assessed using the Critical Appraisal Skills Programme (CASP). In primary searching, we found 1237 articles in total databases. After removing duplicates and applying all inclusion and exclusion criteria, we selected 11 tests for this systematic review. There were a few valid, reliable and comprehensive ToM tests for normal preschool children. However, we had limitations concerning the included articles. The defined ToM tests were different in populations, tasks, mode of presentations, scoring, mode of responses, times and other variables. Also, they had various validities and reliabilities. Therefore, it is recommended that the researchers and clinicians select the ToM tests according to their psychometric characteristics, validity and reliability.

  10. Investigating Postgraduate College Admission Interviews: Generalizability Theory Reliability and Incremental Predictive Validity

    ERIC Educational Resources Information Center

    Arce-Ferrer, Alvaro J.; Castillo, Irene Borges

    2007-01-01

    The use of face-to-face interviews is controversial for college admissions decisions in light of the lack of availability of validity and reliability evidence for most college admission processes. This study investigated reliability and incremental predictive validity of a face-to-face postgraduate college admission interview with a sample of…

  11. Utilizing Generalizability Theory to Investigate the Reliability of the Grades Assigned to Undergraduate Research Papers

    ERIC Educational Resources Information Center

    Gugiu, Mihaiela R.; Gugiu, Paul C.; Baldus, Robert

    2012-01-01

    Background: Educational researchers have long espoused the virtues of writing with regard to student cognitive skills. However, research on the reliability of the grades assigned to written papers reveals a high degree of contradiction, with some researchers concluding that the grades assigned are very reliable whereas others suggesting that they…

  12. Utilizing Generalizability Theory to Investigate the Reliability of the Grades Assigned to Undergraduate Research Papers

    ERIC Educational Resources Information Center

    Gugiu, Mihaiela R.; Gugiu, Paul C.; Baldus, Robert

    2012-01-01

    Background: Educational researchers have long espoused the virtues of writing with regard to student cognitive skills. However, research on the reliability of the grades assigned to written papers reveals a high degree of contradiction, with some researchers concluding that the grades assigned are very reliable whereas others suggesting that they…

  13. Investigating Postgraduate College Admission Interviews: Generalizability Theory Reliability and Incremental Predictive Validity

    ERIC Educational Resources Information Center

    Arce-Ferrer, Alvaro J.; Castillo, Irene Borges

    2007-01-01

    The use of face-to-face interviews is controversial for college admissions decisions in light of the lack of availability of validity and reliability evidence for most college admission processes. This study investigated reliability and incremental predictive validity of a face-to-face postgraduate college admission interview with a sample of…

  14. The chronic toxicity of molybdate to marine organisms. I. Generating reliable effects data.

    PubMed

    Heijerick, D G; Regoli, L; Stubblefield, W

    2012-07-15

    A scientific research program was initiated by the International Molybdenum Association (IMOA) which addressed identified gaps in the environmental toxicity data for the molybdate ion (MoO(4)(2-)). These gaps were previously identified during the preparation of EU-REACH-dossiers for different molybdenum compounds (European Union regulation on Registration, Evaluation, Authorization and Restriction of Chemical substances; EC, 2006). Evaluation of the open literature identified few reliable marine ecotoxicological data that could be used for deriving a Predicted No-Effect Concentration (PNEC) for the marine environment. Rather than calculating a PNEC(marine) using the assessment factor methodology on a combined freshwater/marine dataset, IMOA decided to generate sufficient reliable marine chronic data to permit derivation of a PNEC by means of the more scientifically robust species sensitivity distribution (SSD) approach (also called the statistical extrapolation approach). Nine test species were chronically exposed to molybdate (added as sodium molybdate dihydrate, Na(2)MoO(4)·2H(2)O) according to published standard testing guidelines that are acceptable for a broad range of regulatory purposes. The selected test organisms were representative for typical marine trophic levels: micro-algae/diatom (Phaeodactylum tricornutum, Dunaliella tertiolecta), macro-alga (Ceramium tenuicorne), mysids (Americamysis bahia), copepod (Acartia tonsa), fish (Cyprinodon variegatus), echinoderms (Dendraster exentricus, Strongylocentrotus purpuratus) and molluscs (Mytilus edulis, Crassostrea gigas). Available NOEC/EC(10) levels ranged between 4.4 mg Mo/L (blue mussel M. edulis) and 1174 mg Mo/L (oyster C. gigas). Using all available reliable marine chronic effects data that are currently available, a HC(5,50%) (median hazardous concentration affecting 5% of the species) of 5.74(mg Mo)/L was derived with the statistical extrapolation approach, a value that can be used for national and

  15. Portable SERS-enabled micropipettes for microarea sampling and reliably quantitative detection of surface organic residues.

    PubMed

    Fang, Wei; Zhang, Xinwei; Chen, Yong; Wan, Liang; Huang, Weihua; Shen, Aiguo; Hu, Jiming

    2015-09-15

    We report the first microsampling device for reliably quantitative, label-free and separation-free detection of multicomponents of surface organic residues (SORs) by means of a quality controllable surface-enhanced Raman scattering (SERS)-enabled micropipette. The micropipette is comprised of a drawn glass capillary with a tiny orifice (∼50 μm) at the distal tip, where the specially designed nanorattles (NRs) are compactly coated on the inner wall surface. SERS signals of 4-mercapto benzoic acid (MBA) anchored inside the internal gap of NRs could be used to evaluate and control the quality of micropipettes and, therefore, allow us to overcome the limitations of a reliably quantitative SERS assay using traditional substrates without an internal standard. By dropping a trace extraction agent on targeting SORs located on a narrow surface, the capillary and SERS functionalities of these micropipettes allow on-site microsampling via capillary action and subsequent multiplex distinction/detection due to their molecularly narrow Raman peaks. For example, 8 nM thiram (TMTD), 8 nM malachite green (MG), and 1.5 μM (400 ppb) methyl parathion (MPT) on pepper and cucumber peels have been simultaneously detected in a wide detection range. The portable SERS-enabled device could potentially be facilely incorporated with liquid-liquid or solid phase micro-extracting devices for a broader range of applications in rapid and field analysis of food/public/environment security related SORs.

  16. Magnetoelectroluminescence of organic heterostructures: Analytical theory and spectrally resolved measurements

    SciTech Connect

    Liu, Feilong; Kelley, Megan R.; Crooker, Scott A.; Nie, Wanyi; Mohite, Aditya D.; Ruden, P. Paul; Smith, Darryl L.

    2014-12-22

    The effect of a magnetic field on the electroluminescence of organic light emitting devices originates from the hyperfine interaction between the electron/hole polarons and the hydrogen nuclei of the host molecules. In this paper, we present an analytical theory of magnetoelectroluminescence for organic semiconductors. To be specific, we focus on bilayer heterostructure devices. In the case we are considering, light generation at the interface of the donor and acceptor layers results from the formation and recombination of exciplexes. The spin physics is described by a stochastic Liouville equation for the electron/hole spin density matrix. By finding the steady-state analytical solution using Bloch-Wangsness-Redfield theory, we explore how the singlet/triplet exciplex ratio is affected by the hyperfine interaction strength and by the external magnetic field. In order to validate the theory, spectrally resolved electroluminescence experiments on BPhen/m-MTDATA devices are analyzed. With increasing emission wavelength, the width of the magnetic field modulation curve of the electroluminescence increases while its depth decreases. Furthermore, these observations are consistent with the model.

  17. Magnetoelectroluminescence of organic heterostructures: Analytical theory and spectrally resolved measurements

    DOE PAGES

    Liu, Feilong; Kelley, Megan R.; Crooker, Scott A.; ...

    2014-12-22

    The effect of a magnetic field on the electroluminescence of organic light emitting devices originates from the hyperfine interaction between the electron/hole polarons and the hydrogen nuclei of the host molecules. In this paper, we present an analytical theory of magnetoelectroluminescence for organic semiconductors. To be specific, we focus on bilayer heterostructure devices. In the case we are considering, light generation at the interface of the donor and acceptor layers results from the formation and recombination of exciplexes. The spin physics is described by a stochastic Liouville equation for the electron/hole spin density matrix. By finding the steady-state analytical solutionmore » using Bloch-Wangsness-Redfield theory, we explore how the singlet/triplet exciplex ratio is affected by the hyperfine interaction strength and by the external magnetic field. In order to validate the theory, spectrally resolved electroluminescence experiments on BPhen/m-MTDATA devices are analyzed. With increasing emission wavelength, the width of the magnetic field modulation curve of the electroluminescence increases while its depth decreases. Furthermore, these observations are consistent with the model.« less

  18. Magnetoelectroluminescence of organic heterostructures: Analytical theory and spectrally resolved measurements

    NASA Astrophysics Data System (ADS)

    Liu, Feilong; Kelley, Megan R.; Crooker, Scott A.; Nie, Wanyi; Mohite, Aditya D.; Ruden, P. Paul; Smith, Darryl L.

    2014-12-01

    The effect of a magnetic field on the electroluminescence of organic light emitting devices originates from the hyperfine interaction between the electron/hole polarons and the hydrogen nuclei of the host molecules. In this paper, we present an analytical theory of magnetoelectroluminescence for organic semiconductors. To be specific, we focus on bilayer heterostructure devices. In the case we are considering, light generation at the interface of the donor and acceptor layers results from the formation and recombination of exciplexes. The spin physics is described by a stochastic Liouville equation for the electron/hole spin density matrix. By finding the steady-state analytical solution using Bloch-Wangsness-Redfield theory, we explore how the singlet/triplet exciplex ratio is affected by the hyperfine interaction strength and by the external magnetic field. To validate the theory, spectrally resolved electroluminescence experiments on BPhen/m-MTDATA devices are analyzed. With increasing emission wavelength, the width of the magnetic field modulation curve of the electroluminescence increases while its depth decreases. These observations are consistent with the model.

  19. Monte Carlo Bayesian System Reliability- and MTBF-Confidence Assessment, II. Volume 1. Theory

    DTIC Science & Technology

    1978-03-01

    logic. From George Boole’s classic 1854 book, The Laws of Thought [9], it can be seen that the kind of problem Boole was trying to solve ... to make...system reliability as a function of the component reliabilities. Boole made some errors. His explanation of "inversion" involved a clumsy use of series...D. Esary and S. C. Saunders, "Multi-Component Systems and Structures and Their Reliability," Technometrics, Vol. 3 (1961), pp. 55-77. [9] Boole

  20. Theory of polaron bandwidth narrowing in organic molecular crystals

    NASA Astrophysics Data System (ADS)

    Hannewald, K.; Stojanović, V. M.; Schellekens, J. M.; Bobbert, P. A.; Kresse, G.; Hafner, J.

    2004-02-01

    We present a theoretical description of polaron bandwidth narrowing in organic molecular crystals. Based on a solution of a Holstein-Peierls model for tightly bound electrons interacting with phonons, an explicit expression for the temperature dependence of the electronic bandwidths is found. This formula generalizes the result of Holstein polaron theory by treating local and nonlocal electron-phonon coupling on equal footing. The usefulness of the method is demonstrated by model studies for oligo-acene crystals from which microscopic insight into the relevance of the different coupling mechanisms is obtained.

  1. The "New Institutionalism" in Organization Theory: Bringing Society and Culture Back in

    ERIC Educational Resources Information Center

    Senge, Konstanze

    2013-01-01

    This investigation will discuss the emergence of an economistical perspective among the dominant approaches of organization theory in the United States since the inception of "organization studies" as an academic discipline. It maintains that Contingency theory, Resource Dependency theory, Population Ecology theory, and Transaction Cost theory…

  2. The "New Institutionalism" in Organization Theory: Bringing Society and Culture Back in

    ERIC Educational Resources Information Center

    Senge, Konstanze

    2013-01-01

    This investigation will discuss the emergence of an economistical perspective among the dominant approaches of organization theory in the United States since the inception of "organization studies" as an academic discipline. It maintains that Contingency theory, Resource Dependency theory, Population Ecology theory, and Transaction Cost theory…

  3. Can theory of mind deficits be measured reliably in people with mild and moderate Alzheimer's dementia?

    PubMed

    Choong, Caroline Sm; Doody, Gillian A

    2013-01-01

    Patients suffering from Alzheimer's dementia develop difficulties in social functioning. This has led to an interest in the study of "theory of mind" in this population. However, difficulty has arisen because the associated cognitive demands of traditional short story theory of mind assessments result in failure per se in this population, making it challenging to test pure theory of mind ability. Simplified, traditional 1st and 2nd order theory of mind short story tasks and a battery of alternative theory of mind cartoon jokes and control slapstick cartoon jokes, without memory components, were administered to 16 participants with mild-moderate Alzheimer's dementia, and 11 age-matched healthy controls. No significant differences were detected between participants with Alzheimer's dementia and controls on the 1st or 2nd order traditional short story theory of mind tasks (p = 0.155 and p = 0.154 respectively). However, in the cartoon joke tasks there were significant differences in performance between the Alzheimer participants and the control group, this was evident for both theory of mind cartoons and the control 'slapstick' jokes. It remains very difficult to assess theory of mind as an isolated phenomenon in populations with global cognitive impairment, such as Alzheimer's dementia, as the tasks used to assess this cognition invariably depend on other cognitive functions. Although a limitation of this study is the small sample size, the results suggest that there is no measurable specific theory of mind deficit in people with Alzheimer's dementia, and that the use of theory of mind representational models to measure social cognitive ability may not be appropriate in this population.

  4. Application of SAW method for multiple-criteria comparative analysis of the reliability of heat supply organizations

    NASA Astrophysics Data System (ADS)

    Akhmetova, I. G.; Chichirova, N. D.

    2016-12-01

    Heat supply is the most energy-consuming sector of the economy. Approximately 30% of all used primary fuel-and-energy resources is spent on municipal heat-supply needs. One of the key indicators of activity of heat-supply organizations is the reliability of an energy facility. The reliability index of a heat supply organization is of interest to potential investors for assessing risks when investing in projects. The reliability indices established by the federal legislation are actually reduced to a single numerical factor, which depends on the number of heat-supply outages in connection with disturbances in operation of heat networks and the volume of their resource recovery in the calculation year. This factor is rather subjective and may change in a wide range during several years. A technique is proposed for evaluating the reliability of heat-supply organizations with the use of the simple additive weighting (SAW) method. The technique for integrated-index determination satisfies the following conditions: the reliability level of the evaluated heat-supply system is represented maximum fully and objectively; the information used for the reliability-index evaluation is easily available (is located on the Internet in accordance with demands of data-disclosure standards). For reliability estimation of heat-supply organizations, the following indicators were selected: the wear of equipment of thermal energy sources, the wear of heat networks, the number of outages of supply of thermal energy (heat carrier due to technological disturbances on heat networks per 1 km of heat networks), the number of outages of supply of thermal energy (heat carrier due to technologic disturbances on thermal energy sources per 1 Gcal/h of installed power), the share of expenditures in the cost of thermal energy aimed at recovery of the resource (renewal of fixed assets), coefficient of renewal of fixed assets, and a coefficient of fixed asset retirement. A versatile program is developed

  5. Generalizability Theory Analysis of CBM Maze Reliability in Third- through Fifth-Grade Students

    ERIC Educational Resources Information Center

    Mercer, Sterett H.; Dufrene, Brad A.; Zoder-Martell, Kimberly; Harpole, Lauren Lestremau; Mitchell, Rachel R.; Blaze, John T.

    2012-01-01

    Despite growing use of CBM Maze in universal screening and research, little information is available regarding the number of CBM Maze probes needed for reliable decisions. The current study extends existing research on the technical adequacy of CBM Maze by investigating the number of probes and assessment durations (1-3 min) needed for reliable…

  6. Elaboration and Application of a Theory of Criterion-Referenced Reliability.

    ERIC Educational Resources Information Center

    Lovett, Hubert T.

    The reliability of a criterion referenced test was defined as a measure of the degree to which the test discriminates between an individual's level of performance and a predetermined criterion level. The variances of observed and true scores were defined as the squared deviation of the score from the criterion. Based on these definitions and the…

  7. Reliable thermal processing of organic perovskite films deposited on ZnO

    NASA Astrophysics Data System (ADS)

    Zakhidov, Alex; Manspeaker, Chris; Lyashenko, Dmitry; Alex Zakhidov Team

    Zinc oxide (ZnO) is a promising semiconducting material to serve as an electron transport layer (ETL) for solar cell devices based on organo-halide lead perovskites. ZnO ETL for perovskite photovoltaics has a combination of attractive electronic and optical properties: i) the electron affinity of ZnO is well aligned with valence band edge of the CH3NH3PbI3, ii) electron mobility of ZnO is >1 cm2/(Vs), which is a few orders of magnitude higher than that of TiO2 (another popular choice of ETL for perovskite photovoltaic devices), and iii) ZnO has a large of band gap of 3.3 eV, which ensures optical transparency and large barrier for the hole injection. Moreover, ZnO nanostructures can be printed on flexible substrates at room temperatures in cost effective manner. However, it was recently found that organic perovskites deposited on ZnO are unstable and readily decompose at >90°C. In this work, we further investigate the mechanism of decomposition of CH3NH3PbI3 film deposited on ZnO and reveal the role of the solvent in the film during the annealing process. We also develop a restricted volume solvent annealing (RVSA) process for post annealing of the perovskite film on ZnO without decomposition. We demonstrate that RVSA enables reliable perovskite solar cell fabrication.

  8. Reliability of a viva assessment of clinical reasoning in an Australian pre-professional osteopathy program assessed using generalizability theory

    PubMed Central

    2017-01-01

    Clinical reasoning is situation-dependent and case-specific; therefore, assessments incorporating different patient presentations are warranted. The present study aimed to determine the reliability of a multi-station case-based viva assessment of clinical reasoning in an Australian pre-registration osteopathy program using generalizability theory. Students (from years 4 and 5) and examiners were recruited from the osteopathy program at Southern Cross University, Lismore, Australia. The study took place on a single day in the student teaching clinic. Examiners were trained before the examination. Students were allocated to 1 of 3 rounds consisting of 5 10-minute stations in an objective structured clinical examination-style. Generalizability analysis was used to explore the reliability of the examination. Fifteen students and 5 faculty members participated in the study. The examination produced a generalizability coefficient of 0.53, with 18 stations required to achieve a generalizability coefficient of 0.80. The reliability estimations were acceptable and the psychometric findings related to the marking rubric and overall scores were acceptable; however, further work is required in examiner training and ensuring consistent case difficulty to improve the reliability of the examination. PMID:28104901

  9. Reliability of a viva assessment of clinical reasoning in an Australian pre-professional osteopathy program assessed using generalizability theory.

    PubMed

    Vaughan, Brett; Orrock, Paul; Grace, Sandra

    2017-01-01

    Clinical reasoning is situation-dependent and case-specific; therefore, assessments incorporating different patient presentations are warranted. The present study aimed to determine the reliability of a multi-station case-based viva assessment of clinical reasoning in an Australian pre-registration osteopathy program using generalizability theory. Students (from years 4 and 5) and examiners were recruited from the osteopathy program at Southern Cross University, Lismore, Australia. The study took place on a single day in the student teaching clinic. Examiners were trained before the examination. Students were allocated to 1 of 3 rounds consisting of 5 10-minute stations in an objective structured clinical examination-style. Generalizability analysis was used to explore the reliability of the examination. Fifteen students and 5 faculty members participated in the study. The examination produced a generalizability coefficient of 0.53, with 18 stations required to achieve a generalizability coefficient of 0.80. The reliability estimations were acceptable and the psychometric findings related to the marking rubric and overall scores were acceptable; however, further work is required in examiner training and ensuring consistent case difficulty to improve the reliability of the examination.

  10. Conventional strain energies of azetidine and phosphetane: can density functional theory yield reliable results?

    PubMed

    Smith, Shelley A; Hand, Karen E; Love, Melissa L; Hill, Glake; Magers, David H

    2013-03-15

    The conventional strain energies for azetidine and phosphetane are determined within the isodesmic, homodesmotic, and hyperhomodesmotic models. Optimum equilibrium geometries, harmonic vibrational frequencies, and corresponding electronic energies and zero-point vibrational energies are computed for all pertinent molecular systems using self-consistent field theory, second-order perturbation theory, and density functional theory and using the correlation consistent basis sets cc-pVDZ, cc-pVTZ, and cc-pVQZ. Single point fourth-order perturbation theory, CCSD, and CCSD(T) calculations using the cc-pVTZ and the cc-pVQZ basis sets are computed using the MP2/cc-pVTZ and MP2/cc-pVQZ optimized geometries, respectively, to ascertain the contribution of higher order correlation effects and to determine if the quadruple-zeta valence basis set is needed when higher order correlation is included. In the density functional theory study, eight different functionals are used including B3LYP, wB97XD, and M06-2X to determine if any functional can yield results similar to those obtained at the CCSD(T) level. Copyright © 2012 Wiley Periodicals, Inc.

  11. Theory of hydrogen migration in organic-inorganic halide perovskites.

    PubMed

    Egger, David A; Kronik, Leeor; Rappe, Andrew M

    2015-10-12

    Solar cells based on organic-inorganic halide perovskites have recently been proven to be remarkably efficient. However, they exhibit hysteresis in their current-voltage curves, and their stability in the presence of water is problematic. Both issues are possibly related to a diffusion of defects in the perovskite material. By using first-principles calculations based on density functional theory, we study the properties of an important defect in hybrid perovskites-interstitial hydrogen. We show that differently charged defects occupy different crystal sites, which may allow for ionization-enhanced defect migration following the Bourgoin-Corbett mechanism. Our analysis highlights the structural flexibility of organic-inorganic perovskites: successive iodide displacements, combined with hydrogen bonding, enable proton diffusion with low migration barriers. These findings indicate that hydrogen defects can be mobile and thus highly relevant for the performance of perovskite solar cells. © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

  12. Do Choice Experiments Generate Reliable Willingness to Pay Estimates Theory and Experimental Evidence

    DTIC Science & Technology

    2015-01-01

    predictions of voting theory combined with the theoretical model from Part II? A. Experiment 2 Design 15 Experiment 2 is designed to create a...the choice set design methodologies. The experiment took 40-45 minutes to complete, and average experimental earnings were in the range of $ 15 -$20.6...student take-home pay ranges from $65-$100. Thus, an additional $ 15 -$20 for 45 minutes to one hour of time represents a significant addition to a

  13. Reliability of surgical skills scores in otolaryngology residents: analysis using generalizability theory.

    PubMed

    Fernandez, Soledad A; Wiet, Gregory J; Butler, Nancy N; Welling, Bradley; Jarjoura, David

    2008-12-01

    Assessments of temporal bone dissection performance among otolaryngology residents have not been adequately developed. At the Ohio State College of Medicine, an instrument (Welling Scale, Version 1 [WS1]) is used to evaluate residents' end-product performance after drilling a temporal bone. In this study, the authors evaluate the components that contribute to measurement error using this scale. Generalizability theory was used to reveal components of measurement error that allow for better understanding of test results. A major component of measurement error came from inconsistency in performance across the two cadaveric test bones each resident was assigned. In contrast, ratings of performance using the WS1 were highly consistent across raters and rating sessions within raters. The largest source of measurement error was caused by residents' inconsistent performance across bones. Rater disagreement introduced only small error into scores. The WS1 provides small measurement error, with two raters and two bones for each participant.

  14. Reliable Energy Level Alignment at Physisorbed Molecule–Metal Interfaces from Density Functional Theory

    PubMed Central

    2015-01-01

    A key quantity for molecule–metal interfaces is the energy level alignment of molecular electronic states with the metallic Fermi level. We develop and apply an efficient theoretical method, based on density functional theory (DFT) that can yield quantitatively accurate energy level alignment information for physisorbed metal–molecule interfaces. The method builds on the “DFT+Σ” approach, grounded in many-body perturbation theory, which introduces an approximate electron self-energy that corrects the level alignment obtained from conventional DFT for missing exchange and correlation effects associated with the gas-phase molecule and substrate polarization. Here, we extend the DFT+Σ approach in two important ways: first, we employ optimally tuned range-separated hybrid functionals to compute the gas-phase term, rather than rely on GW or total energy differences as in prior work; second, we use a nonclassical DFT-determined image-charge plane of the metallic surface to compute the substrate polarization term, rather than the classical DFT-derived image plane used previously. We validate this new approach by a detailed comparison with experimental and theoretical reference data for several prototypical molecule–metal interfaces, where excellent agreement with experiment is achieved: benzene on graphite (0001), and 1,4-benzenediamine, Cu-phthalocyanine, and 3,4,9,10-perylene-tetracarboxylic-dianhydride on Au(111). In particular, we show that the method correctly captures level alignment trends across chemical systems and that it retains its accuracy even for molecules for which conventional DFT suffers from severe self-interaction errors. PMID:25741626

  15. Reliable Energy Level Alignment at Physisorbed Molecule–Metal Interfaces from Density Functional Theory

    DOE PAGES

    Egger, David A.; Liu, Zhen-Fei; Neaton, Jeffrey B.; ...

    2015-03-05

    We report a key quantity for molecule–metal interfaces is the energy level alignment of molecular electronic states with the metallic Fermi level. We develop and apply an efficient theoretical method, based on density functional theory (DFT) that can yield quantitatively accurate energy level alignment information for physisorbed metal–molecule interfaces. The method builds on the “DFT+Σ” approach, grounded in many-body perturbation theory, which introduces an approximate electron self-energy that corrects the level alignment obtained from conventional DFT for missing exchange and correlation effects associated with the gas-phase molecule and substrate polarization. Here, we extend the DFT+Σ approach in two important ways:more » first, we employ optimally tuned range-separated hybrid functionals to compute the gas-phase term, rather than rely on GW or total energy differences as in prior work; second, we use a nonclassical DFT-determined image-charge plane of the metallic surface to compute the substrate polarization term, rather than the classical DFT-derived image plane used previously. We validate this new approach by a detailed comparison with experimental and theoretical reference data for several prototypical molecule–metal interfaces, where excellent agreement with experiment is achieved: benzene on graphite (0001), and 1,4-benzenediamine, Cu-phthalocyanine, and 3,4,9,10-perylene-tetracarboxylic-dianhydride on Au(111). In particular, we show that the method correctly captures level alignment trends across chemical systems and that it retains its accuracy even for molecules for which conventional DFT suffers from severe self-interaction errors.« less

  16. Evaluation of neural network robust reliability using information-gap theory.

    PubMed

    Pierce, S Gareth; Ben-Haim, Yakov; Worden, Keith; Manson, Graeme

    2006-11-01

    A novel technique for the evaluation of neural network robustness against uncertainty using a nonprobabilistic approach is presented. Conventional optimization techniques were employed to train multilayer perceptron (MLP) networks, which were then probed with an uncertainty analysis using an information-gap model to quantify the network response to uncertainty in the input data. It is demonstrated that the best performing network on data with low uncertainty is not in general the optimal network on data with a higher degree of input uncertainty. Using the concepts of information-gap theory, this paper develops a theoretical framework for information-gap uncertainty applied to neural networks, and explores the practical application of the procedure to three sample cases. The first consists of a simple two-dimensional (2-D) classification network operating on a known Gaussian distribution, the second a nine-lass vibration classification problem from an aircraft wing, and the third a two-class example from a database of breast cancer incidence.

  17. Reliability of Density Functional and Perturbation Theories for Calculating Core-Ionization Spectra of Free Radicals.

    PubMed

    Ljubić, Ivan

    2014-06-10

    The C 1s, N 1s, and O 1s ionization energies were calculated for the three stable nitroxide free radicals, viz., tempo and its two analogues, and compared to their most recent high-resolution core photoelectron spectra. We compare the performance of unrestricted and restricted open shell based ΔHF, ΔMP2, and ΔB3LYP methods. A mixed basis set is employed in all cases, which consists of the core-valence correlation-consistent triple-ζ basis set (cc-pCVTZ or cc-pwCVTZ) on the atom whose core-electron binding energy is calculated, model core potentials on the remaining first row atoms, and the cc-pVDZ basis set on the hydrogen atoms. The best overall performance for the three free radicals is offered by the restricted open shell based ΔB3LYP method. Surprisingly, both the restricted open and unrestricted second-order perturbation theories perform relatively poorly and typically do not warrant additional computational effort over the reference ΔHF methods. This is particularly true of the ΔZAPT method, which exhibits a number of grave failures that render it unsuitable for calculating the core-ionization spectra.

  18. A theory-based instrument to evaluate team communication in the operating room: balancing measurement authenticity and reliability.

    PubMed

    Lingard, Lorelei; Regehr, Glenn; Espin, Sherry; Whyte, Sarah

    2006-12-01

    Breakdown in communication among members of the healthcare team threatens the effective delivery of health services, and raises the risk of errors and adverse events. To describe the process of developing an authentic, theory-based evaluation instrument that measures communication among members of the operating room team by documenting communication failures. 25 procedures were viewed by 3 observers observing in pairs, and records of events on each communication failure observed were independently completed by each observer. Each record included the type and outcome of the failure (both selected from a checklist of options), as well as the time of occurrence and a description of the event. For each observer, records of events were compiled to create a profile for the procedure. At the level of identifying events in the procedure, mean inter-rater agreement was low (mean agreement across pairs 47.3%). However, inter-rater reliability regarding the total number of communication failures per procedure was reasonable (mean ICC across pairs 0.72). When observers recorded the same event, a strong concordance about the type of communication failure represented by the event was found. Reasonable inter-rater reliability was shown by the instrument in assessing the relative rate of communication failures displayed per procedure. The difficulties in identifying and interpreting individual communication events reflect the delicate balance between increased subtlety and increased error. Complex team communication does not readily reduce to mere observation of events; some level of interpretation is required to meaningfully account for communicative exchanges. Although such observer interpretation improves the subtlety and validity of the instrument, it necessarily introduces error, reducing reliability. Although we continue to work towards increasing the instrument's sensitivity at the level of individual categories, this study suggests that the instrument could be used to

  19. A theory for the arrangement of sensory organs in Drosophila

    NASA Astrophysics Data System (ADS)

    Zhu, Huifeng; Gunaratne, Preethi H.; Roman, Gregg W.; Gunaratne, Gemunu H.

    2010-03-01

    We study the arrangements of recurved bristles on the anterior wing margin of wild-type and mutant Drosophila. The epidermal or neural fate of a proneural cell depends on the concentrations of proteins of the achaete-scute complex. At puparium formation, concentrations of proteins are nearly identical in all cells of the anterior wing and each cell has the potential for neural fate. In wild-type flies, the action of regulatory networks drives the initial state to one where a bristle grows out of every fifth cell. Recent experiments have shown that the frequency of recurved bristles can be made to change by adjusting the mean concentrations of the zinc-finger transcription factor Senseless and the micro-RNA miR-9a. Specifically, mutant flies with reduced levels of miR-9a exhibit ectopic bristles, and those with lower levels of both miR-9a and Senseless show regular organization of recurved bristles, but with a lower periodicity of 4. We argue that these characteristics can be explained assuming an underlying Turing-type bifurcation whereby a periodic pattern spontaneously emerges from a uniform background. However, bristle patterns occur in a discrete array of cells, and are not mediated by diffusion. We argue that intracellular actions of transmembrane proteins such as Delta and Notch can play a role of diffusion in destabilizing the homogeneous state. In contrast to diffusion, intercellular actions can be activating or inhibiting; further, there can be lateral cross-species interactions. We introduce a phenomenological model to study bristle arrangements and make several model-independent predictions that can be tested in experiments. In our theory, miRNA-9a is one of the components of the underlying network and has no special regulatory role. The loss of periodicity in its absence is due to the transfer of the system to a bistable state.

  20. Reliable and simple spectrophotometric determination of sun protection factor: A case study using organic UV filter-based sunscreen products.

    PubMed

    Yang, Soo In; Liu, Shuanghui; Brooks, Geoffrey J; Lanctot, Yves; Gruber, James V

    2017-08-23

    Current in vitro SPF screening method for plant oil body (oleosome)-based SPF products possesses significant inconsistency and low reliability in the SPF rating. The primary objective of this study was to evaluate the reliability and reproducibility of spectrophotometrically determined sun protection factor (SPF) from oleosome-based SPF products. The secondary objective was the data comparison of the spectrophotometric measurements against in vivo SPF testing to establish a reliable in vitro test method as a screening assay. Octyl methoxycinnamate (UVB filter) and avobenzone (UVA filter) were loaded into safflower oil bodies and formulated into oil-in-water emulsion-based finished products. To evaluate the reliability between in vivo and spectrophotometric test methods, samples were dispatched to a clinical laboratory, and the reported SPF values were compared with spectrophotometric test results. The observed SPF from the in vivo and spectrophotometric test results demonstrated a high correlation for SPF 30 products. Proportional correlation between the two evaluation methods was observed for SPF 15 and 50 products with slightly lesser accuracy with a smaller number of population tested in the clinical studies. A reliable spectrophotometric screening method for oil body-based SPF formulas has been developed using two broadly used organic UV sunscreen actives as a case study. The results demonstrated a high level of reproducibility and reliability compared to the US FDA-guided in vivo SPF testing method. © 2017 The Authors. Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc.

  1. How Settings Change People: Applying Behavior Setting Theory to Consumer-Run Organizations

    ERIC Educational Resources Information Center

    Brown, Louis D.; Shepherd, Matthew D.; Wituk, Scott A.; Meissen, Greg

    2007-01-01

    Self-help initiatives stand as a classic context for organizational studies in community psychology. Behavior setting theory stands as a classic conception of organizations and the environment. This study explores both, applying behavior setting theory to consumer-run organizations (CROs). Analysis of multiple data sets from all CROs in Kansas…

  2. How Settings Change People: Applying Behavior Setting Theory to Consumer-Run Organizations

    ERIC Educational Resources Information Center

    Brown, Louis D.; Shepherd, Matthew D.; Wituk, Scott A.; Meissen, Greg

    2007-01-01

    Self-help initiatives stand as a classic context for organizational studies in community psychology. Behavior setting theory stands as a classic conception of organizations and the environment. This study explores both, applying behavior setting theory to consumer-run organizations (CROs). Analysis of multiple data sets from all CROs in Kansas…

  3. Assessing Variations in Areal Organization for the Intrinsic Brain: From Fingerprints to Reliability

    PubMed Central

    Xu, Ting; Opitz, Alexander; Craddock, R. Cameron; Wright, Margaret J.; Zuo, Xi-Nian; Milham, Michael P.

    2016-01-01

    Resting state fMRI (R-fMRI) is a powerful in-vivo tool for examining the functional architecture of the human brain. Recent studies have demonstrated the ability to characterize transitions between functionally distinct cortical areas through the mapping of gradients in intrinsic functional connectivity (iFC) profiles. To date, this novel approach has primarily been applied to iFC profiles averaged across groups of individuals, or in one case, a single individual scanned multiple times. Here, we used a publically available R-fMRI dataset, in which 30 healthy participants were scanned 10 times (10 min per session), to investigate differences in full-brain transition profiles (i.e., gradient maps, edge maps) across individuals, and their reliability. 10-min R-fMRI scans were sufficient to achieve high accuracies in efforts to “fingerprint” individuals based upon full-brain transition profiles. Regarding test–retest reliability, the image-wise intraclass correlation coefficient (ICC) was moderate, and vertex-level ICC varied depending on region; larger durations of data yielded higher reliability scores universally. Initial application of gradient-based methodologies to a recently published dataset obtained from twins suggested inter-individual variation in areal profiles might have genetic and familial origins. Overall, these results illustrate the utility of gradient-based iFC approaches for studying inter-individual variation in brain function. PMID:27600846

  4. Aligning the Undergraduate Organic Laboratory Experience with Professional Work: The Centrality of Reliable and Meaningful Data

    ERIC Educational Resources Information Center

    Alaimo, Peter J.; Langenhan, Joseph M.; Suydam, Ian T.

    2014-01-01

    Many traditional organic chemistry lab courses do not adequately help students to develop the professional skills required for creative, independent work. The overarching goal of the new organic chemistry lab series at Seattle University is to teach undergraduates to think, perform, and behave more like professional scientists. The conversion of…

  5. Aligning the Undergraduate Organic Laboratory Experience with Professional Work: The Centrality of Reliable and Meaningful Data

    ERIC Educational Resources Information Center

    Alaimo, Peter J.; Langenhan, Joseph M.; Suydam, Ian T.

    2014-01-01

    Many traditional organic chemistry lab courses do not adequately help students to develop the professional skills required for creative, independent work. The overarching goal of the new organic chemistry lab series at Seattle University is to teach undergraduates to think, perform, and behave more like professional scientists. The conversion of…

  6. Left-right organizer flow dynamics: how much cilia activity reliably yields laterality?

    PubMed

    Sampaio, Pedro; Ferreira, Rita R; Guerrero, Adán; Pintado, Petra; Tavares, Bárbara; Amaro, Joana; Smith, Andrew A; Montenegro-Johnson, Thomas; Smith, David J; Lopes, Susana S

    2014-06-23

    Internal organs are asymmetrically positioned inside the body. Embryonic motile cilia play an essential role in this process by generating a directional fluid flow inside the vertebrate left-right organizer. Detailed characterization of how fluid flow dynamics modulates laterality is lacking. We used zebrafish genetics to experimentally generate a range of flow dynamics. By following the development of each embryo, we show that fluid flow in the left-right organizer is asymmetric and provides a good predictor of organ laterality. This was tested in mosaic organizers composed of motile and immotile cilia generated by dnah7 knockdowns. In parallel, we used simulations of fluid dynamics to analyze our experimental data. These revealed that fluid flow generated by 30 or more cilia predicts 90% situs solitus, similar to experimental observations. We conclude that cilia number, dorsal anterior motile cilia clustering, and left flow are critical to situs solitus via robust asymmetric charon expression.

  7. Reliability training

    NASA Technical Reports Server (NTRS)

    Lalli, Vincent R. (Editor); Malec, Henry A. (Editor); Dillard, Richard B.; Wong, Kam L.; Barber, Frank J.; Barina, Frank J.

    1992-01-01

    Discussed here is failure physics, the study of how products, hardware, software, and systems fail and what can be done about it. The intent is to impart useful information, to extend the limits of production capability, and to assist in achieving low cost reliable products. A review of reliability for the years 1940 to 2000 is given. Next, a review of mathematics is given as well as a description of what elements contribute to product failures. Basic reliability theory and the disciplines that allow us to control and eliminate failures are elucidated.

  8. An examination of maintenance activities in liquid metal reactor facilities: An analysis by the Centralized Reliability Data Organization (CREDO)

    SciTech Connect

    Haire, M J; Knee, H E; Manning, J J; Manneschmidt, J F; Setoguchi, K

    1987-01-01

    The Centralized Reliability Data Organization (CREDO) is the largest repository of liquid metal reactor (LMR) component reliability data in the world. It is jointly sponsored by the US Department of Energy (DOE) and the Power Reactor and Nuclear fuel Development Corporation (PNC) of Japan. The CREDO database contains information on a population of more than 21,000 components and approximately 1300 event records. Total experience is approaching 1.2 billion component operating hours. Although data gathering for CREDO concentrates on event (failure) information, the work reported here focuses on the maintenance information contained in CREDO and the development of maintenance critical items lists. That is, components are ranked in prioritized lists from worse to best performers from a maintenance standpoint.

  9. First evidence on the validity and reliability of the Safety Organizing Scale-Nursing home version (SOS-NH)

    PubMed Central

    Ausserhofer, Dietmar; Anderson, Ruth A.; Colón-Emeric, Cathleen; Schwendimann, René

    2013-01-01

    Background The Safety Organizing Scale is a valid and reliable measure on safety behaviors and practices in hospitals. Purpose of the study This study aimed to explore the psychometric properties of the Safety Organizing Scale-Nursing Home version (SOS-NH). Design and Methods In a cross-sectional analysis of staff survey data, we examined validity and reliability of the 9-item Safety SOS-NH using American Educational Research Association guidelines. Subjects and Setting This sub-study of a larger trial used baseline survey data collected from staff members (n=627) in a variety of work roles in 13 NHs in North Carolina and Virginia, USA. Results Psychometric evaluation of the SOS-NH revealed good response patterns with low average of missing values across all items (3.05%). Analyses of the SOS-NH’s internal structure (e.g., comparative fit indices = 0.929, standardized root mean square error of approximation = 0.045) and consistency (composite reliability = 0.94) suggested its one-dimensionality. Significant between-facility variability, intraclass correlations, within-group agreement and design effect confirmed appropriateness of the SOS-NH for measurement at the NH level, justifying data aggregation. The SOS-NH showed discriminate validity from one related concept, communication openness. Implications Initial evidence regarding validity and reliability of the SOS-NH supports its’ utility in measuring safety behaviors and practices among a wide range of NH staff members, including those with low literacy. Further psychometric evaluation should focus on testing concurrent and criterion validity, using resident outcome measures (e.g., patient fall rates). PMID:23684122

  10. Substance use stigma: Reliability and validity of a theory-based scale for substance-using populations.

    PubMed

    Smith, Laramie R; Earnshaw, Valerie A; Copenhaver, Michael M; Cunningham, Chinazo O

    2016-05-01

    Substance use disorders consistently rank among the most stigmatized conditions worldwide. Thus, substance use stigma fosters health inequities among persons with substance use disorders and remains a key barrier to successful screening and treatment efforts. Current efforts to measure substance use stigma are limited. This study aims to advance measurement efforts by drawing on stigma theory to develop and evaluate the Substance Use Stigma Mechanisms Scale (SU-SMS). The SU-SMS was designed to capture enacted, anticipated, and internalized Substance Use Stigma Mechanisms among persons with current and past substance use disorders, and distinguish between key stigma sources most likely to impact this target population. This study was a cross-sectional evaluation of the validity, reliability, and generalizability of the SU-SMS across two independent samples with diverse substance use and treatment histories. Findings support the structural and construct validity of the SU-SMS, suggesting the scale was able to capture enacted, anticipated, and internalized stigma as distinct stigma experiences. It also further differentiated between two distinct stigma sources (family and healthcare providers). Analysis of these mechanisms and psychosocial metrics suggests that the scale is also associated with other health-related outcomes. Furthermore, the SU-SMS demonstrated high levels of internal reliability and generalizability across two independent samples of persons with diverse substance use disorders and treatment histories. The SU-SMS may serve as a valuable tool for better understanding the processes through which substance use stigma serves to undermine key health behaviors and outcomes among persons with substance use disorders. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  11. Substance Use Stigma: Reliability and validity of a theory-based scale for substance-using populations*

    PubMed Central

    Smith, Laramie R.; Earnshaw, Valerie A.; Copenhaver, Michael M.; Cunningham, Chinazo O.

    2016-01-01

    Background Substance use disorders consistently rank among the most stigmatized conditions worldwide. Thus, substance use stigma fosters health inequities among persons with substance use disorders and remains a key barrier to successful screening and treatment efforts. Current efforts to measure substance use stigma are limited. This study aims to advance measurement efforts by drawing on stigma theory to develop and evaluate the Substance Use Stigma Mechanisms Scale (SU-SMS). The SU-SMS was designed to capture enacted, anticipated, and internalized substance use stigma mechanisms among persons with current and past substance use disorders, and distinguish between key stigma sources most likely to impact this target population. Methods This study was a cross-sectional evaluation of the validity, reliability, and generalizability of the SU-SMS across two independent samples with diverse substance use and treatment histories. Results Findings support the structural and construct validity of the SU-SMS, suggesting the scale was able to capture enacted, anticipated, and internalized stigma as distinct stigma experiences. It also further differentiated between two distinct stigma sources (family and healthcare providers). Analysis of these mechanisms and psychosocial metrics suggests that the scale is also associated with other health-related outcomes. Furthermore, the SU-SMS demonstrated high levels of internal reliability and generalizability across two independent samples of persons with diverse substance use disorders and treatment histories. Conclusion The SU-SMS may serve as a valuable tool for better understanding the processes through which substance use stigma serves to undermine key health behaviors and outcomes among persons with substance use disorders. PMID:26972790

  12. Including a measure of health status in Medicare's health maintenance organization capitation formula: reliability issues.

    PubMed

    Lichtenstein, R; Thomas, J W

    1987-02-01

    Medicare's formula for determining capitation levels for risk-based HMOs, the Adjusted Average Per Capita Cost (AAPCC), has been criticized as a poor basis for establishing payments. Among new adjusting factors suggested for the formula is a measure of beneficiaries' functional health status. The ability of such a measure to improve predictions of Medicare costs has been demonstrated in several studies. In addition to possessing predictive validity, a measure considered for inclusion in the AAPCC must also be reliable. In this paper, the authors examine a measure of functional health status for intrarater reliability or, equivalently, stability over time. A sample of 1,616 Medicare beneficiaries was surveyed twice--in late 1982 and in January 1984. Using a five-point scale, functional health status scores were calculated for each of the beneficiaries at two points in time. For 68.4% of the sample, functional health scores were unchanged over the year, and second-year scores were within one point of first-year scores for 94.3% of the sample. Based on the intraclass correlation coefficient, the scores on this functional health scale demonstrated substantial to "almost perfect" agreement over the 1-year period.

  13. The chronic toxicity of molybdate to freshwater organisms. I. Generating reliable effects data.

    PubMed

    De Schamphelaere, K A C; Stubblefield, W; Rodriguez, P; Vleminckx, K; Janssen, C R

    2010-10-15

    The European Union regulation on Registration, Evaluation, Authorization and Restriction of Chemical substances (REACH) (EC, 2006) requires the characterization of the chronic toxicity of many chemicals in the aquatic environment, including molybdate (MoO(4)(2-)). Our literature review on the ecotoxicity of molybdate revealed that a limited amount of reliable chronic no observed effect concentrations (NOECs) for the derivation of a predicted no-effect concentration (PNEC) existed. This paper presents the results of additional ecotoxicity experiments that were conducted in order to fulfill the requirements for the derivation of a PNEC by means of the scientifically most robust species sensitivity distribution (SSD) approach (also called the statistical extrapolation approach). Ten test species were chronically exposed to molybdate (added as sodium molybdate dihydrate, Na(2)MoO(4)·2H(2)O) according to internationally accepted standard testing guidelines or equivalent. The 10% effective concentrations (EC10, expressed as measured dissolved molybdenum) for the most sensitive endpoint per species were 62.8-105.6 (mg Mo)/L for Daphnia magna (21day-reproduction), 78.2 (mg Mo)/L for Ceriodaphnia dubia (7day-reproduction), 61.2-366.2 (mg Mo)/L for the green alga Pseudokirchneriella subcapitata (72h-growth rate), 193.6 (mg Mo)/L for the rotifer Brachionus calyciflorus (48h-population growth rate), 121.4 (mg Mo)/L for the midge Chironomus riparius (14day-growth), 211.3 (mg Mo)/L for the snail Lymnaea stagnalis (28day-growth rate), 115.9 (mg Mo)/L for the frog Xenopus laevis (4day-larval development), 241.5 (mg Mo)/L for the higher plant Lemna minor (7day-growth rate), 39.3 (mg Mo)/L for the fathead minnow Pimephales promelas (34day-dry weight/biomass), and 43.2 (mg Mo)/L for the rainbow trout Oncorhynchus mykiss (78day-biomass). These effect concentrations are in line with the few reliable data currently available in the open literature. The data presented in this study can

  14. Implications of Complexity and Chaos Theories for Organizations that Learn

    ERIC Educational Resources Information Center

    Smith, Peter A. C.

    2003-01-01

    In 1996 Hubert Saint-Onge and Smith published an article ("The evolutionary organization: avoiding a Titanic fate", in The Learning Organization, Vol. 3 No. 4), based on their experience at the Canadian Imperial Bank of Commerce (CIBC). It was established at CIBC that change could be successfully facilitated through blended application…

  15. Implications of Complexity and Chaos Theories for Organizations that Learn

    ERIC Educational Resources Information Center

    Smith, Peter A. C.

    2003-01-01

    In 1996 Hubert Saint-Onge and Smith published an article ("The evolutionary organization: avoiding a Titanic fate", in The Learning Organization, Vol. 3 No. 4), based on their experience at the Canadian Imperial Bank of Commerce (CIBC). It was established at CIBC that change could be successfully facilitated through blended application…

  16. A simple, rapid, and reliable protocol to localize hydrogen peroxide in large plant organs by DAB-mediated tissue printing.

    PubMed

    Liu, Yong-Hua; Offler, Christina E; Ruan, Yong-Ling

    2014-01-01

    Hydrogen peroxide (H2O2) is a major reactive oxygen species (ROS) and plays diverse roles in plant development and stress responses. However, its localization in large and thick plant organs (e.g., stem, roots, and fruits), other than leaves, has proven to be challenging due to the difficulties for the commonly used H2O2-specific chemicals, such as 3,3'-diaminobenzidine (DAB), cerium chloride (CeCl3), and 2',7'-dichlorofluorescin diacetate (H2DCF-DA), to penetrate those organs. Theoretically, the reaction of endogenous H2O2 with these chemicals could be facilitated by using thin organ sections. However, the rapid production of wound-induced H2O2 associated with this procedure inevitably disturbs the original distribution of H2O2 in vivo. Here, by employing tomato seedling stems and fruits as testing materials, we report a novel, simple, and rapid protocol to localize H2O2 in those organs using DAB-mediated tissue printing. The rapidity of the protocol (within 15 s) completely avoided the interference of wound-induced H2O2 during experimentation. Moreover, the H2O2 signal on the printing was stable for at least 1 h with no or little background produced. We conclude that DAB-mediated tissue printing developed here provide a new feasible and reliable method to localize H2O2 in large plant organs, hence should have broad applications in studying ROS biology.

  17. Development of a reliable and valid organization-specific professional practice assessment tool.

    PubMed

    Hitchings, Kim; Capuano, Terry; Bokovoy, Joanna; Houser, Janet

    2010-01-01

    This article describes a study to devise an organization-specific professional practice model (PPM) assessment that reflects actual unit involvement. A secondary study goal is the development of a unit-based index that can be used to conduct comparative analyses in an efficient way. Each of the 5 elements of the organization's PPM was represented by 1 or more items on an author-developed instrument. The tool was structured so that item scores could be summed to achieve a single subscale for each PPM element and further aggregated into a total score. The instrument was administered to a 40% random sample of all regularly scheduled, full- and part-time registered nurses in an academic, community Magnet hospital in 2003 and 2005. Descriptive statistics were calculated for items, subscales, and summary scores for each patient care unit and overall. A weighted, unit-based index was developed to reflect each unit's score on a scale of 100. The 2003 assessment response rate was 51% (n = 200); the 2005 response rate was 48% (n = 193). Subscale scores and a total PPM score were calculated by summing the values of each individual item. Submissions enabled calculations of total scores by unit, mean scores by item, and the development of a unit-specific PPM index of performance. Beyond shared principles of empowerment, the specifics of each organization's PPM may differ in those key components of care delivery nurses are empowered to effect. Thus, fidelity to the organization-specific PPM is not well tested with generic decisional-involvement instruments. An organization-specific assessment such as this one can provide evidence of not only organizational PPM fidelity but a quantitative method to ensure that staff nurse decisional involvement is continuously evolving to an ever higher state.

  18. Surrogacy theory and models of convoluted organic systems.

    PubMed

    Konopka, Andrzej K

    2007-03-01

    The theory of surrogacy is briefly outlined as one of the conceptual foundations of systems biology that has been developed for the last 30 years in the context of Hertz-Rosen modeling relationship. Conceptual foundations of modeling convoluted (biologically complex) systems are briefly reviewed and discussed in terms of current and future research in systems biology. New as well as older results that pertain to the concepts of modeling relationship, sequence of surrogacies, cascade of representations, complementarity, analogy, metaphor, and epistemic time are presented together with a classification of models in a cascade. Examples of anticipated future applications of surrogacy theory in life sciences are briefly discussed.

  19. Reliable measurement of the Seebeck coefficient of organic and inorganic materials between 260 K and 460 K

    SciTech Connect

    Beretta, D.; Lanzani, G.; Bruno, P.; Caironi, M.

    2015-07-15

    A new experimental setup for reliable measurement of the in-plane Seebeck coefficient of organic and inorganic thin films and bulk materials is reported. The system is based on the “Quasi-Static” approach and can measure the thermopower in the range of temperature between 260 K and 460 K. The system has been tested on a pure nickel bulk sample and on a thin film of commercially available PEDOT:PSS deposited by spin coating on glass. Repeatability within 1.5% for the nickel sample is demonstrated, while accuracy in the measurement of both organic and inorganic samples is guaranteed by time interpolation of data and by operating with a temperature difference over the sample of less than 1 K.

  20. Reliable thin film encapsulation for organic light emitting diodes grown by low-temperature atomic layer deposition

    NASA Astrophysics Data System (ADS)

    Meyer, J.; Schneidenbach, D.; Winkler, T.; Hamwi, S.; Weimann, T.; Hinze, P.; Ammermann, S.; Johannes, H.-H.; Riedl, T.; Kowalsky, W.

    2009-06-01

    We report on highly efficient gas diffusion barriers for organic light emitting diodes (OLEDs). Nanolaminate (NL) structures composed of alternating Al2O3 and ZrO2 sublayers grown by atomic layer deposition at 80 °C are used to realize long-term stable OLED devices. While the brightness of phosphorescent p-i-n OLEDs sealed by a single Al2O3 layer drops to 85% of the initial luminance of 1000 cd/m2 after 1000 h of continuous operation, OLEDs encapsulated with the NL retain more than 95% of their brightness. An extrapolated device lifetime substantially in excess of 10 000 h can be achieved, clearly proving the suitability of the NLs as highly dense and reliable thin film encapsulation of sensitive organic electronic devices.

  1. Using Multivariate Generalizability Theory to Assess the Effect of Content Stratification on the Reliability of a Performance Assessment

    ERIC Educational Resources Information Center

    Keller, Lisa A.; Clauser, Brian E.; Swanson, David B.

    2010-01-01

    In recent years, demand for performance assessments has continued to grow. However, performance assessments are notorious for lower reliability, and in particular, low reliability resulting from task specificity. Since reliability analyses typically treat the performance tasks as randomly sampled from an infinite universe of tasks, these estimates…

  2. Using Multivariate Generalizability Theory to Assess the Effect of Content Stratification on the Reliability of a Performance Assessment

    ERIC Educational Resources Information Center

    Keller, Lisa A.; Clauser, Brian E.; Swanson, David B.

    2010-01-01

    In recent years, demand for performance assessments has continued to grow. However, performance assessments are notorious for lower reliability, and in particular, low reliability resulting from task specificity. Since reliability analyses typically treat the performance tasks as randomly sampled from an infinite universe of tasks, these estimates…

  3. Cracking Silent Codes: Critical Race Theory and Education Organizing

    ERIC Educational Resources Information Center

    Su, Celina

    2007-01-01

    Critical race theory (CRT) has moved beyond legal scholarship to critique the ways in which "colorblind" laws and policies perpetuate existing racial inequalities in education policy. While criticisms of CRT have focused on the pessimism and lack of remedies presented, CRT scholars have begun to address issues of praxis. Specifically,…

  4. An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 1. Technical Report #1216

    ERIC Educational Resources Information Center

    Anderson, Daniel; Park, Jasmine, Bitnara; Lai, Cheng-Fei; Alonzo, Julie; Tindal, Gerald

    2012-01-01

    This technical report is one in a series of five describing the reliability (test/retest/and alternate form) and G-Theory/D-Study research on the easy CBM reading measures, grades 1-5. Data were gathered in the spring 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest. Due…

  5. A Comparison of the Approaches of Generalizability Theory and Item Response Theory in Estimating the Reliability of Test Scores for Testlet-Composed Tests

    ERIC Educational Resources Information Center

    Lee, Guemin; Park, In-Yong

    2012-01-01

    Previous assessments of the reliability of test scores for testlet-composed tests have indicated that item-based estimation methods overestimate reliability. This study was designed to address issues related to the extent to which item-based estimation methods overestimate the reliability of test scores composed of testlets and to compare several…

  6. A Comparison of the Approaches of Generalizability Theory and Item Response Theory in Estimating the Reliability of Test Scores for Testlet-Composed Tests

    ERIC Educational Resources Information Center

    Lee, Guemin; Park, In-Yong

    2012-01-01

    Previous assessments of the reliability of test scores for testlet-composed tests have indicated that item-based estimation methods overestimate reliability. This study was designed to address issues related to the extent to which item-based estimation methods overestimate the reliability of test scores composed of testlets and to compare several…

  7. How Reliable is the Bulk δ13C value of Soil Organic Matter in Paleovegetational Reconstruction?

    NASA Astrophysics Data System (ADS)

    Sanyal, P.; Rakshit, S.

    2015-12-01

    Carbon isotope ratios of soil/paleosol organic matter (δ13CSOM) have been used to reconstruct abundance of C3-C4 plants survived in the landscape as the δ13C value of C3 (-27‰) and C4 (-12.5 ‰) plants are distinctly different. In an attempt to reconstruct the abundance of C3 and C4 plants, δ13CSOM have been measured from three soil profiles developed on flood plain of the Gangetic plain, Mohanpur, West Bengal, India. Satellite images reveal that the investigated sediments have been deposited in an oxbow lake setting of the river Ganges. The total organic carbon content of the profile ranges from 0.9% to 0.1%. The δ13CSOM values mostly range from -19.2‰ to -22‰ except a rapid positive excursions of ~5‰ at 1.5 m depth showing enriched value (-14.2‰) in all the three profiles. Based on mass balance calculation using the δ13C values of C3 and C4 plants, the δ13CSOM in the Gangetic plain indicate presence of both C3 and C4 plants in the floodplain. However, characterization of alkanes separated from lipids extracted from the same soil organic matter reveals dominant preferences in short carbon chain (C14, C16, C18, C20) with a little preferences for higher chain (C29, C31, C33). Interestingly, n-alkanes at 1.5 m depth shows very high concentration in short chain n-alkanes. Since the lower chain n-alkane represents aquatic productivity or intense bacterial decomposition and higher chain indicates the contribution from C3-C4 plants, the data from the investigated sedimentary profile shows contribution mostly from aquatic vegetation with a little contribution from terrestrial plants. This implies that before using bulk δ13CSOM value for reconstruction of C3-C4 plants from soil/paleosol, characterization (molecular level) of soil organic matter is required

  8. Charge carrier hopping transport based on Marcus theory and variable-range hopping theory in organic semiconductors

    NASA Astrophysics Data System (ADS)

    Lu, Nianduan; Li, Ling; Banerjee, Writam; Sun, Pengxiao; Gao, Nan; Liu, Ming

    2015-07-01

    Charge carrier hopping transport is generally taken from Miller-Abrahams and Marcus transition rates. Based on the Miller-Abrahams theory and nearest-neighbour range hopping theory, Apsley and Hughes developed a concise calculation method (A-H method) to study the hopping conduction in disordered systems. Here, we improve the A-H method to investigate the charge carrier hopping transport by introducing polaron effect and electric field based on Marcus theory and variable-range hopping theory. This improved method can well describe the contribution of polaron effect, energetic disorder, carrier density, and electric field to the charge carrier transport in disordered organic semiconductor. In addition, the calculated results clearly show that the charge carrier mobility represents different polaron effect dependence with the polaron activation energy and decreases with increasing electric field strength for large fields.

  9. The contribution of organization theory to nursing health services research.

    PubMed

    Mick, Stephen S; Mark, Barbara A

    2005-01-01

    We review nursing and health services research on health care organizations over the period 1950 through 2004 to reveal the contribution of nursing to this field. Notwithstanding this rich tradition and the unique perspective of nursing researchers grounded in patient care production processes, the following gaps in nursing research remain: (1) the lack of theoretical frameworks about organizational factors relating to internal work processes; (2) the need for sophisticated methodologies to guide empirical investigations; (3) the difficulty in understanding how organizations adapt models for patient care delivery in response to market forces; (4) the paucity of attention to the impact of new technologies on the organization of patient care work processes. Given nurses' deep understanding of the inner workings of health care facilities, we hope to see an increasing number of research programs that tackle these deficiencies.

  10. Economic and Political Theories of Organization: The Case of Human Rights INGOs.

    ERIC Educational Resources Information Center

    Blaser, Arthur W.

    This paper reviews research on international nongovernmental organizations dealing with human rights (INGOs), and interprets this research in light of the overlap of the fields of organizational theory (including group theory) and human rights. The purpose is to contribute toward a useful exchange between social scientists who seek to explain…

  11. Prolegomena to a Primitive Theory of Human Communication in Human Organizations.

    ERIC Educational Resources Information Center

    Dance, Frank E. X.

    1979-01-01

    Calls for a reordering of values in the study of human communication in human organizations. Offers a preliminary discourse on a primitive theory of human communication as distinguished from an eclectic theory of organizational communication. Differences between the two types of theoretical approaches are suggested. (JMF)

  12. Can the second order multireference perturbation theory be considered a reliable tool to study mixed-valence compounds?

    NASA Astrophysics Data System (ADS)

    Pastore, Mariachiara; Helal, Wissam; Evangelisti, Stefano; Leininger, Thierry; Malrieu, Jean-Paul; Maynau, Daniel; Angeli, Celestino; Cimiraglia, Renzo

    2008-05-01

    In this paper, the problem of the calculation of the electronic structure of mixed-valence compounds is addressed in the frame of multireference perturbation theory (MRPT). Using a simple mixed-valence compound (the 5,5' (4H,4H')-spirobi[ciclopenta[c]pyrrole] 2,2',6,6' tetrahydro cation), and the n-electron valence state perturbation theory (NEVPT2) and CASPT2 approaches, it is shown that the ground state (GS) energy curve presents an unphysical "well" for nuclear coordinates close to the symmetric case, where a maximum is expected. For NEVPT, the correct shape of the energy curve is retrieved by applying the MPRT at the (computationally expensive) third order. This behavior is rationalized using a simple model (the ionized GS of two weakly interacting identical systems, each neutral system being described by two electrons in two orbitals), showing that the unphysical well is due to the canonical orbital energies which at the symmetric (delocalized) conformation lead to a sudden modification of the denominators in the perturbation expansion. In this model, the bias introduced in the second order correction to the energy is almost entirely removed going to the third order. With the results of the model in mind, one can predict that all MRPT methods in which the zero order Hamiltonian is based on canonical orbital energies are prone to present unreasonable energy profiles close to the symmetric situation. However, the model allows a strategy to be devised which can give a correct behavior even at the second order, by simply averaging the orbital energies of the two charge-localized electronic states. Such a strategy is adopted in a NEVPT2 scheme obtaining a good agreement with the third order results based on the canonical orbital energies. The answer to the question reported in the title (is this theoretical approach a reliable tool for a correct description of these systems?) is therefore positive, but care must be exercised, either in defining the orbital energies

  13. Reliability of equivalent sphere model in blood-forming organ dose estimation

    SciTech Connect

    Shinn, J.L.; Wilson, J.W.; Nealy, J.E.

    1990-04-01

    The radiation dose equivalents to blood-forming organs (BFO's) of the astronauts at the Martian surface due to major solar flare events are calculated using the detailed body geometry of Langley and Billings. The solar flare spectra of February 1956, November 1960, and August 1972 events are employed instead of the idealized Webber form. The detailed geometry results are compared with those based on the 5-cm sphere model which was used often in the past to approximate BFO dose or dose equivalent. Larger discrepancies are found for the later two events possibly due to the lower numbers of highly penetrating protons. It is concluded that the 5-cm sphere model is not suitable for quantitative use in connection with future NASA deep-space, long-duration mission shield design studies.

  14. Reliability of equivalent sphere model in blood-forming organ dose estimation

    NASA Technical Reports Server (NTRS)

    Shinn, Judy L.; Wilson, John W.; Nealy, John E.

    1990-01-01

    The radiation dose equivalents to blood-forming organs (BFO's) of the astronauts at the Martian surface due to major solar flare events are calculated using the detailed body geometry of Langley and Billings. The solar flare spectra of February 1956, November 1960, and August 1972 events are employed instead of the idealized Webber form. The detailed geometry results are compared with those based on the 5-cm sphere model which was used often in the past to approximate BFO dose or dose equivalent. Larger discrepancies are found for the later two events possibly due to the lower numbers of highly penetrating protons. It is concluded that the 5-cm sphere model is not suitable for quantitative use in connection with future NASA deep-space, long-duration mission shield design studies.

  15. A Theory of Electronic Propinquity: Mediated Communication in Organizations.

    ERIC Educational Resources Information Center

    Korzenny, Felipe

    This paper proposes a theoretical approach to mediated communication in organizations. It is argued that the man/machine interface in mediated human communication is better dealt with when a comprehensive theoretical approach is used than when separate communication devices are tested as they appear in the market, such as video-teleconferencing.…

  16. A Theory of Electronic Propinquity: Mediated Communication in Organizations

    ERIC Educational Resources Information Center

    Korzenny, Felipe

    1978-01-01

    Proposes a theoretical approach to mediated communication in organizations suggesting that man-machine interface in mediated human communication is more effectively dealt with by using a comprehensive theoretical approach rather than separate communication devices that are tested as they appear in the market. (MH)

  17. Toward a theory of the functional organization of the retina

    NASA Astrophysics Data System (ADS)

    Ratliff, Charles P.

    2007-12-01

    The retina streams visual information to the brain through parallel channels with highly stereotyped patterns of organization and connection. Much progress has been made toward identifying the types of neurons present, and their connectivity. A key problem is inferring the function of a neural system based on its known anatomy and physiology, and identifying the advantages conferred by its particular design. Often, characterizing its architecture reveals some strange features of its organization, and the utility of these features is not always explained easily. Here evidence is presented that several intriguing 'design features' of the retina can be explained by careful application of a single hypothesis: that the retina is organized to maximize the information transmitted about natural visual stimuli, subject to a set of biophysical constraints. Specifically, the input neurons to the retina (photoreceptors) and the output neurons (ganglion cells) exhibit the following interesting features: (1) In trichromats, cone photoreceptors with peak sensitivity to long (L), medium (M) and short (S) wavelengths of light are asymmetrically distributed, so that the ratio of L/M (red/green) cones is highly variable, and S (blue) cones are relatively scarce. (2) Ganglion cell receptive fields are organized so that 3-4 cells of the same type represent each point in a visual image. (3) The retina devotes more resources to ganglion cells selective for negative contrasts (OFF cells) than those selective for positive contrasts (ON cells). (4) The shape of ganglion cell center/surround receptive fields depends on their spatial scale, so that the ratio of surround size to center size decreases with the visual angle subtended by the receptive field. In each case, statistical properties of natural visual stimuli could be coupled with realistic biophysical constraints to account for the features described. The analyses here constitute progress toward long-standing questions concerning the

  18. A simple, rapid, and reliable protocol to localize hydrogen peroxide in large plant organs by DAB-mediated tissue printing

    PubMed Central

    Liu, Yong-Hua; Offler, Christina E.; Ruan, Yong-Ling

    2014-01-01

    Hydrogen peroxide (H2O2) is a major reactive oxygen species (ROS) and plays diverse roles in plant development and stress responses. However, its localization in large and thick plant organs (e.g., stem, roots, and fruits), other than leaves, has proven to be challenging due to the difficulties for the commonly used H2O2-specific chemicals, such as 3,3′-diaminobenzidine (DAB), cerium chloride (CeCl3), and 2′,7′-dichlorofluorescin diacetate (H2DCF-DA), to penetrate those organs. Theoretically, the reaction of endogenous H2O2 with these chemicals could be facilitated by using thin organ sections. However, the rapid production of wound-induced H2O2 associated with this procedure inevitably disturbs the original distribution of H2O2 in vivo. Here, by employing tomato seedling stems and fruits as testing materials, we report a novel, simple, and rapid protocol to localize H2O2 in those organs using DAB-mediated tissue printing. The rapidity of the protocol (within 15 s) completely avoided the interference of wound-induced H2O2 during experimentation. Moreover, the H2O2 signal on the printing was stable for at least 1 h with no or little background produced. We conclude that DAB-mediated tissue printing developed here provide a new feasible and reliable method to localize H2O2 in large plant organs, hence should have broad applications in studying ROS biology. PMID:25566310

  19. Push-Pull Receptive Field Organization and Synaptic Depression: Mechanisms for Reliably Encoding Naturalistic Stimuli in V1

    PubMed Central

    Kremkow, Jens; Perrinet, Laurent U.; Monier, Cyril; Alonso, Jose-Manuel; Aertsen, Ad; Frégnac, Yves; Masson, Guillaume S.

    2016-01-01

    Neurons in the primary visual cortex are known for responding vigorously but with high variability to classical stimuli such as drifting bars or gratings. By contrast, natural scenes are encoded more efficiently by sparse and temporal precise spiking responses. We used a conductance-based model of the visual system in higher mammals to investigate how two specific features of the thalamo-cortical pathway, namely push-pull receptive field organization and fast synaptic depression, can contribute to this contextual reshaping of V1 responses. By comparing cortical dynamics evoked respectively by natural vs. artificial stimuli in a comprehensive parametric space analysis, we demonstrate that the reliability and sparseness of the spiking responses during natural vision is not a mere consequence of the increased bandwidth in the sensory input spectrum. Rather, it results from the combined impacts of fast synaptic depression and push-pull inhibition, the later acting for natural scenes as a form of “effective” feed-forward inhibition as demonstrated in other sensory systems. Thus, the combination of feedforward-like inhibition with fast thalamo-cortical synaptic depression by simple cells receiving a direct structured input from thalamus composes a generic computational mechanism for generating a sparse and reliable encoding of natural sensory events. PMID:27242445

  20. The Application of Open Systems Theory and Organization Development to Higher Education: A Position.

    ERIC Educational Resources Information Center

    Kessel, Vicki; Mink, Oscar G.

    This monograph sets forth a portion of the research and theory base underlying the organization development program, 1 of the 3 major components of the National Laboratory for Higher Education''s Administrative and Organizational Systems program. It depicts some of the linkages among organization development, institutional research, information…

  1. Reliability and validity of World Health Organization Quality of Life-100 in homeless substance-dependent veteran population.

    PubMed

    Garcia-Rea, Elizabeth; LePage, James P

    2008-01-01

    The number of homeless individuals and specifically homeless veterans is increasing. Accurate assessment of quality of life is an important need in working with this population because of the myriad problems encountered. However, the reliability and validity of quality-of-life instruments have not been assessed in this population. This study evaluated the psychometric properties of the U.S. version of the World Health Organization Quality of Life-100 in a homeless veteran population. Results found adequate internal consistency for all domain and most facet scores, while test-retest stability varied for the facet scores. We confirmed validity by using subsamples with physical, emotional, and social problems and by comparing scores from populations that returned to the community with employment and housing. Limitations and directions for future study are discussed.

  2. Increasing Reliability of Direct Observation Measurement Approaches in Emotional and/or Behavioral Disorders Research Using Generalizability Theory

    ERIC Educational Resources Information Center

    Gage, Nicholas A.; Prykanowski, Debra; Hirn, Regina

    2014-01-01

    Reliability of direct observation outcomes ensures the results are consistent, dependable, and trustworthy. Typically, reliability of direct observation measurement approaches is assessed using interobserver agreement (IOA) and the calculation of observer agreement (e.g., percentage of agreement). However, IOA does not address intraobserver…

  3. Increasing Reliability of Direct Observation Measurement Approaches in Emotional and/or Behavioral Disorders Research Using Generalizability Theory

    ERIC Educational Resources Information Center

    Gage, Nicholas A.; Prykanowski, Debra; Hirn, Regina

    2014-01-01

    Reliability of direct observation outcomes ensures the results are consistent, dependable, and trustworthy. Typically, reliability of direct observation measurement approaches is assessed using interobserver agreement (IOA) and the calculation of observer agreement (e.g., percentage of agreement). However, IOA does not address intraobserver…

  4. Theory of zwitterionic molecular-based organic magnets

    NASA Astrophysics Data System (ADS)

    Shelton, William A.; Aprà, Edoardo; Sumpter, Bobby G.; Saraiva-Souza, Aldilene; Souza Filho, Antonio G.; Nero, Jordan Del; Meunier, Vincent

    2011-08-01

    We describe a class of organic molecular magnets based on zwitterionic molecules (betaine derivatives) possessing donor, π bridge, and acceptor groups. Using extensive electronic structure calculations we show the electronic ground-state in these systems is magnetic. In addition, we show that the large energy differences computed for the various magnetic states indicate a high Neel temperature. The quantum mechanical nature of the magnetic properties originates from the conjugated π bridge (only p electrons) in cooperation with the molecular donor-acceptor character. The exchange interactions between electron spin are strong, local, and independent on the length of the π bridge.

  5. Theory of Soret coefficients in binary organic solvents.

    PubMed

    Semenov, Semen; Schimpf, Martin

    2014-03-20

    Thermodiffusion in binary molecular liquids is examined using the nonequilibrium thermodynamic model, where the thermodynamic parameters are calculated using equations based on statistical mechanics. In this approach, thermodiffusion is quantified through the variation in binary chemical potential and its temperature and concentration dependence. The model is applied to solutions of organic solvents, in order to compare our theoretical results to experimental results from the literature. A measurable contribution of the orientation-dependent Keezom interaction is shown, where the possible orientations are averaged using the Boltzmann weighting factor. Calculations of enthalpies of evaporation from the model yield good agreement with experimental values from the literature. However, calculations of the associated energetic parameters were several times larger than those reported in the literature from numeric simulations of material transport.

  6. Validity and reliability analysis of the planned behavior theory scale related to the testicular self-examination in a Turkish context.

    PubMed

    Iyigun, Emine; Tastan, Sevinc; Ayhan, Hatice; Kose, Gulsah; Acikel, Cengizhan

    2016-06-01

    This study aimed to determine the validity and reliability levels of the Planned Behavior Theory Scale as related to a testicular self-examination. The study was carried out in a health-profession higher-education school in Ankara, Turkey, from April to June 2012. The study participants comprised 215 male students. Study data were collected by using a questionnaire, a planned behavior theory scale related to testicular self-examination, and Champion's Health Belief Model Scale (CHBMS). The sub-dimensions of the planned behavior theory scale, namely those of intention, attitude, subjective norms and self-efficacy, were found to have Cronbach's alpha values of between 0.81 and 0.89. Exploratory factor analysis showed that items of the scale had five factors that accounted for 75% of the variance. Of these, the sub-dimension of intention was found to have the highest level of contribution. A significant correlation was found between the sub-dimensions of the testicular self-examination planned behavior theory scale and those of CHBMS (p < 0.05). The findings suggest that the Turkish version of the testicular self-examination Planned Behavior Theory Scale is a valid and reliable measurement for Turkish society.

  7. Near-misses are an opportunity to improve patient safety: adapting strategies of high reliability organizations to healthcare.

    PubMed

    Van Spall, Harriette; Kassam, Alisha; Tollefson, Travis T

    2015-08-01

    Near-miss investigations in high reliability organizations (HROs) aim to mitigate risk and improve system safety. Healthcare settings have a higher rate of near-misses and subsequent adverse events than most high-risk industries, but near-misses are not systematically reported or analyzed. In this review, we will describe the strategies for near-miss analysis that have facilitated a culture of safety and continuous quality improvement in HROs. Near-miss analysis is routine and systematic in HROs such as aviation. Strategies implemented in aviation include the Commercial Aviation Safety Team, which undertakes systematic analyses of near-misses, so that findings can be incorporated into Standard Operating Procedures (SOPs). Other strategies resulting from incident analyses include Crew Resource Management (CRM) for enhanced communication, situational awareness training, adoption of checklists during operations, and built-in redundancy within systems. Health care organizations should consider near-misses as opportunities for quality improvement. The systematic reporting and analysis of near-misses, commonplace in HROs, can be adapted to health care settings to prevent adverse events and improve clinical outcomes.

  8. An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Passage Reading Fluency Assessments: Grade 4. Technical Report #1219

    ERIC Educational Resources Information Center

    Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Lai, Cheng-Fei; Tindal, Gerald

    2012-01-01

    This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

  9. An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 5. Technical Report #1220

    ERIC Educational Resources Information Center

    Lai, Cheng-Fei; Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Tindal, Gerald

    2012-01-01

    This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

  10. An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Reading Assessments: Grade 2. Technical Report #1217

    ERIC Educational Resources Information Center

    Anderson, Daniel; Lai, Cheg-Fei; Park, Bitnara Jasmine; Alonzo, Julie; Tindal, Gerald

    2012-01-01

    This technical report is one in a series of five describing the reliability (test/retest an alternate form) and G-Theory/D-Study on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from the convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest. Due to…

  11. Lay theories of suicide: test-restest reliability and further validation of lester and bean's attribution of causes to suicide scale.

    PubMed

    Loibl, Lisa Mariella; Tran, Ulrich S; Hirner, Alexander; Voracek, Martin

    2008-03-01

    Lay theories on abnormal behavior and mental disorders have been growing as a field recently. Lester and Bean have contributed to these endeavors by developing the Lester and Bean Attribution of Causes to Suicides Scale (1992), an instrument that gauges beliefs concerning the causes of suicidal behavior (intrapsychic, interpersonal, and societal causes). To provide test-retest reliability figures (two-month interval) and to further validate the scale. The instrument was administered to 155 Austrian psychology undergraduates. Test-retest reliabilities, scale intercorrelations, and correlations with locus of control, among others, were ascertained. Test-retest reliabilities amounted to r = 0.67 for intrapsychic, 0.53 for interpersonal, and 0.56 for societal causes, and to 0.59 for the total scale (all ps < 0.001). All three subscales were, as previously observed, significantly positively intercorrelated. Belief in intrapsychic causes was weakly positively related to the internality dimension of the locus of control construct, beliefs in interpersonal and in societal causes were significantly positively associated with societal externality, and there was a significant positive correlation of the fatalistic externality dimension with all three subscales of the Lester-Bean Scale. In view of the moderate internal scale consistencies, the test-retest reliabilities can be seen as satisfying. The significant intercorrelations among attributed causes of suicide further support the hypothesis that the critical dimension of lay theories of suicide is the belief that suicide has definite causes, regardless of the type of cause. Directions for future research are discussed.

  12. Shock interaction with organized structures: Theory and computation

    NASA Astrophysics Data System (ADS)

    Ding, Zhong

    Unsteady interactions between shocks and turbulence are important phenomena frequently encountered in high-speed flows. In this dissertation the problem of a shock interaction with an entropy spot is studied by means of both theoretical analysis and nonlinear computation. The main objective of the studies is to apply both theoretical and computational approaches to study the physics underlying such shock interaction process. The theoretical analysis is based on the Fourier decomposition of the upstream disturbance, the interaction of each Fourier mode with the shock, and the reconstruction of the downstream disturbance via the inverse Fourier transform. The theory is linear in that it assumes the principle of superposition and that the Rankine-Hugoniot relations are linearized about the mean position of the shock. The numerical simulation is carried out within the framework of the unsteady and compressible Euler equations, coupled with an equation for the shock motion, solved numerically by a sixth-order accurate spatial scheme and a fourth-order Runge-Kutta time-integration method. Analyses of the results are concentrated on the case of a Mach 2.0 shock interaction with an entropy spot that has a Gaussian density distribution. The theoretical analysis and the numerical simulation are verified with each other for small amplitude disturbances. The roles of the evanescent and the non-evanescent waves and the mechanisms for downstream disturbance generations are explored in details. In addition, the quasi three-dimensional interaction between a shock and a vortex ring is investigated computationally within the framework of the axisymmetric Euler equations. The vortex ring, which is based on Lamb's formula, has an upstream circulation Gamma = 0.01 and its aspect ratio R lies in the range 8 ≤ R ≤ 100. The shock Mach number varies in the range 1.1 ≤ M1 ≤ 1.8. The interaction results in the streamwise compression of the vortex core and the generation of a toroidal

  13. A predictive theory of charge separation in organic photovoltaics interfaces

    NASA Astrophysics Data System (ADS)

    Troisi, Alessandro; Liu, Tao; Caruso, Domenico; Cheung, David L.; McMahon, David P.

    2012-09-01

    The key process in organic photovoltaics cells is the separation of an exciton, close to the donor/acceptor interface into a free hole (in the donor) and a free electron (in the acceptor). In an efficient solar cell, the majority of absorbed photons generate such hole-electron pairs but it is not clear why such a charge separation process is so efficient in some blends (for example in the blend formed by poly(3- hexylthiophene) (P3HT) and a C60 derivative (PCBM)) and how can one design better OPV materials. The electronic and geometric structure of the prototypical polymer:fullerene interface (P3HT:PCBM) is investigated theoretically using a combination of classical and quantum simulation methods. It is shown that the electronic structure of P3HT in contact with PCBM is significantly altered compared to bulk P3HT. Due to the additional free volume of the interface, P3HT chains close to PCBM are more disordered and, consequently, they are characterized by an increased band gap. Excitons and holes are therefore repelled by the interface. This provides a possible explanation of the low recombination efficiency and supports the direct formation of "quasi-free" charge separated species at the interface. This idea is further explored here by using a more general system-independent model Hamiltonian. The long range exciton dissociation rate is computed as a function of the exciton distance from the interface and the average dissociation distance is evaluated by comparing this rate with the exciton migration rate with a kinetic model. The phenomenological model shows that also in a generic interface the direct formation if quasi-free charges is extremely likely.

  14. Targeting helicase-dependent amplification products with an electrochemical genosensor for reliable and sensitive screening of genetically modified organisms.

    PubMed

    Moura-Melo, Suely; Miranda-Castro, Rebeca; de-Los-Santos-Álvarez, Noemí; Miranda-Ordieres, Arturo J; Dos Santos Junior, J Ribeiro; da Silva Fonseca, Rosana A; Lobo-Castañón, Maria Jesús

    2015-08-18

    Cultivation of genetically modified organisms (GMOs) and their use in food and feed is constantly expanding; thus, the question of informing consumers about their presence in food has proven of significant interest. The development of sensitive, rapid, robust, and reliable methods for the detection of GMOs is crucial for proper food labeling. In response, we have experimentally characterized the helicase-dependent isothermal amplification (HDA) and sequence-specific detection of a transgene from the Cauliflower Mosaic Virus 35S Promoter (CaMV35S), inserted into most transgenic plants. HDA is one of the simplest approaches for DNA amplification, emulating the bacterial replication machinery, and resembling PCR but under isothermal conditions. However, it usually suffers from a lack of selectivity, which is due to the accumulation of spurious amplification products. To improve the selectivity of HDA, which makes the detection of amplification products more reliable, we have developed an electrochemical platform targeting the central sequence of HDA copies of the transgene. A binary monolayer architecture is built onto a thin gold film where, upon the formation of perfect nucleic acid duplexes with the amplification products, these are enzyme-labeled and electrochemically transduced. The resulting combined system increases genosensor detectability up to 10(6)-fold, allowing Yes/No detection of GMOs with a limit of detection of ∼30 copies of the CaMV35S genomic DNA. A set of general utility rules in the design of genosensors for detection of HDA amplicons, which may assist in the development of point-of-care tests, is also included. The method provides a versatile tool for detecting nucleic acids with extremely low abundance not only for food safety control but also in the diagnostics and environmental control areas.

  15. A Study of the Readiness of Hospitals for Implementation of High Reliability Organizations Model in Tehran University of Medical Sciences.

    PubMed

    Mousavi, Seyed Mohammad Hadi; Dargahi, Hossein; Mohammadi, Sara

    2016-10-01

    Creating a safe of health care system requires the establishment of High Reliability Organizations (HROs), which reduces errors, and increases the level of safety in hospitals. This model focuses on improving reliability through higher process design, building a culture of accreditation, and leveraging human factors. The present study intends to determine the readiness of hospitals for the establishment of HROs model in Tehran University of Medical Sciences from the viewpoint of managers of these hospitals. This is a descriptive-analytical study carried out in 2013-2014. The research population consists of 105 senior and middle managers of 15 hospitals of Tehran University of Medical Sciences. The data collection tool was a 55-question researcher-made questionnaire, included six elements of HROs to assess the level of readiness for establishing HROS model from managers' point of view. The validity of the questionnaire was calculated through the content validity method using 10 experts in the area of hospitals' accreditation, and its reliability was calculated through test-retest method with a correlation coefficient of 0.90. The response rate was 90 percent. The Likert scale was used for the questions, and data analysis was conducted through SPSS version 21 Descriptive statistics was presented via tables and normal distributions of data and means. Analytical methods, including t-test, Mann-Whitney, Spearman, and Kruskal-Wallis, were used for presenting inferential statistics. The study showed that from the viewpoint of senior and middle managers of the hospitals considered in this study, these hospitals are indeed ready for acceptance and establishment of HROs model. A significant relationship was showed between HROs model and its elements with demographic details of managers like their age, work experience, management experience, and level of management. Although the studied hospitals, as viewed by their managers, are capable of attaining the goals of HROs, it

  16. Molecular Electron Density Theory: A Modern View of Reactivity in Organic Chemistry.

    PubMed

    Domingo, Luis R

    2016-09-30

    A new theory for the study of the reactivity in Organic Chemistry, named Molecular Electron Density Theory (MEDT), is proposed herein. MEDT is based on the idea that while the electron density distribution at the ground state is responsible for physical and chemical molecular properties, as proposed by the Density Functional Theory (DFT), the capability for changes in electron density is responsible for molecular reactivity. Within MEDT, the reactivity in Organic Chemistry is studied through a rigorous quantum chemical analysis of the changes of the electron density as well as the energies associated with these changes along the reaction path in order to understand experimental outcomes. Studies performed using MEDT allow establishing a modern rationalisation and to gain insight into molecular mechanisms and reactivity in Organic Chemistry.

  17. Towards a Theory of Variation in the Organization of the Word Reading System

    PubMed Central

    Rueckl, Jay G.

    2015-01-01

    The strategy underlying most computational models of word reading is to specify the organization of the reading system—its architecture and the processes and representations it employs—and to demonstrate that this organization would give rise to the behavior observed in word reading tasks. This approach fails to adequately address the variation in reading behavior observed across and within linguistic communities. Only computational models that incorporate learning can fully account for variation in organization. However, even extant learning models (e.g., the triangle model) must be extended if they are to fully account for variation in organization. The challenges associated with extending theories in this way are discussed. PMID:26997862

  18. [A new view of Wolfgang Gutmann and the "Organism-Centred Theory"].

    PubMed

    Weinich, Detlef

    2003-01-01

    Six years after the death of the founder of the so-called 'Organism-Centred Theory' - Prof. Dr. Wolfgang Friedrich Gutmann died on 15 April 1997 - it is obvious that numerous aspects of this theoretical system, which were highly controversial while GUTMANN was still alive, are today gaining increasing acceptance. Two things are worth noting here: on the one hand it can be observed that statements from this concept, also known as the "Frankfurt Theory" (FT), are slowly establishing themselves in the scientific community as everyday scientific knowledge, that is, without being identified as intrinsic parts of the organism-centred theory. On the other hand it cannot be ignored that a rethinking process and an assumption of construction-morphological ideas has been observed, even among those bio-scientists who firmly regard themselves as representatives of the traditional view of evolution theory oriented towards Darwinian evolution paradigms. In terms of content, this transformation focuses on the evaluation of two central points of "organism-centred theory": on the one hand, GUTMANN's criticism of reductionism is finding an increasing number of followers, and futhermore, his idea that an organism itself actively generates and creates its own form has been convincingly confirmed by a number of more recent cellular findings.

  19. Keeping patients safe in healthcare organizations: a structuration theory of safety culture.

    PubMed

    Groves, Patricia S; Meisenbach, Rebecca J; Scott-Cawiezell, Jill

    2011-08-01

    This paper presents a discussion of the use of structuration theory to facilitate understanding and improvement of safety culture in healthcare organizations. Patient safety in healthcare organizations is an important problem worldwide. Safety culture has been proposed as a means to keep patients safe. However, lack of appropriate theory limits understanding and improvement of safety culture. The proposed structuration theory of safety culture was based on a critique of available English-language literature, resulting in literature published from 1983 to mid-2009. CINAHL, Communication and Mass Media Complete, ABI/Inform and Google Scholar databases were searched using the following terms: nursing, safety, organizational culture and safety culture. When viewed through the lens of structuration theory, safety culture is a system involving both individual actions and organizational structures. Healthcare organization members, particularly nurses, share these values through communication and enact them in practice, (re)producing an organizational safety culture system that reciprocally constrains and enables the actions of the members in terms of patient safety. This structurational viewpoint illuminates multiple opportunities for safety culture improvement. Nurse leaders should be cognizant of competing value-based culture systems in the organization and attend to nursing agency and all forms of communication when attempting to create or strengthen a safety culture. Applying structuration theory to the concept of safety culture reveals a dynamic system of individual action and organizational structure constraining and enabling safety practice. Nurses are central to the (re)production of this safety culture system. © 2011 Blackwell Publishing Ltd.

  20. Application of fuzzy set and Dempster-Shafer theory to organic geochemistry interpretation

    NASA Technical Reports Server (NTRS)

    Kim, C. S.; Isaksen, G. H.

    1993-01-01

    An application of fuzzy sets and Dempster Shafter Theory (DST) in modeling the interpretational process of organic geochemistry data for predicting the level of maturities of oil and source rock samples is presented. This was accomplished by (1) representing linguistic imprecision and imprecision associated with experience by a fuzzy set theory, (2) capturing the probabilistic nature of imperfect evidences by a DST, and (3) combining multiple evidences by utilizing John Yen's generalized Dempster-Shafter Theory (GDST), which allows DST to deal with fuzzy information. The current prototype provides collective beliefs on the predicted levels of maturity by combining multiple evidences through GDST's rule of combination.

  1. Egalitarian and maximin theories of justice: directed donation of organs for transplant.

    PubMed

    Veatch, R M

    1998-08-01

    It is common to interpret Rawls's maximin theory of justice as egalitarian. Compared to utilitarian theories, this may be true. However, in special cases practices that distribute resources so as to benefit the worst off actually increase the inequality between the worst off and some who are better off. In these cases the Rawlsian maximin parts company with what is here called true egalitarianism. A policy question requiring a distinction between maximin and "true egalitarian" allocations has arisen in the arena of organ transplantation. This case is examined here as a venue for differentiating maximin and true egalitarian theories. Directed donation is the name given to donations of organs restricted to a particular social group. For example, the family of a member of the Ku Klux Klan donated his organs on the provision that they go only to members of the Caucasian race. While such donations appear to be discriminatory, if certain plausible assumptions are made, they satisfy the maximin criterion. They selectively advantage the recipient of the organs without harming anyone (assuming the organs would otherwise go unused). Moreover, everyone who is lower on the waiting list (who, thereby, could be considered worse off) is advantaged by moving up on the waiting list. This paper examines how maximin and more truly egalitarian theories handle this case arguing that, to the extent that directed donation is unethical, the best account of that conclusion is that an egalitarian principle of justice is to be preferred to the maximin.

  2. Service quality and maturity of health care organizations through the lens of Complexity Leadership Theory.

    PubMed

    Horvat, Ana; Filipovic, Jovan

    2017-07-17

    This research focuses on Complexity Leadership Theory and the relationship between leadership-examined through the lens of Complexity Leadership Theory-and organizational maturity as an indicator of the performance of health organizations. The research adopts a perspective that conceptualizes organizations as complex adaptive systems and draws upon a survey of opinion of 189 managers working in Serbian health organizations. As the results indicate a dependency between functions of leadership and levels of the maturity of health organizations, we propose a model that connects the two. The study broadens our understanding of the implications of complexity thinking and its reflection on leadership functions and overall organizational performance. The correlations between leadership functions and maturity could have practical applications in policy processing, thus improving the quality of outcomes and the overall level of service quality. © 2017 John Wiley & Sons, Ltd.

  3. Customer-organization relationships: development and test of a theory of extended identities.

    PubMed

    Bagozzi, Richard P; Bergami, Massimo; Marzocchi, Gian Luca; Morandin, Gabriele

    2012-01-01

    We develop a theory of personal, relational, and collective identities that links organizations and consumers. Four targets of identity are studied: small friendship groups of aficionados of Ducati motorcycles, virtual communities centered on Ducatis, the Ducati brand, and Ducati the company. The interplay amongst the identities is shown to order affective, cognitive, and evaluative reactions toward each target. Hypotheses are tested on a sample of 210 Ducati aficionados, and implications of these multiple, extended identities for organizations are examined.

  4. Applications of the Conceptual Density Functional Theory Indices to Organic Chemistry Reactivity.

    PubMed

    Domingo, Luis R; Ríos-Gutiérrez, Mar; Pérez, Patricia

    2016-06-09

    Theoretical reactivity indices based on the conceptual Density Functional Theory (DFT) have become a powerful tool for the semiquantitative study of organic reactivity. A large number of reactivity indices have been proposed in the literature. Herein, global quantities like the electronic chemical potential μ, the electrophilicity ω and the nucleophilicity N indices, and local condensed indices like the electrophilic P k + and nucleophilic P k - Parr functions, as the most relevant indices for the study of organic reactivity, are discussed.

  5. Command and Control in Virtual Environments: Using Contingency Theory to Understand Organization in Virtual Worlds

    DTIC Science & Technology

    2010-10-01

    DWAM90947 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Mark E. Nissen 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...than half a century [1]. Beginning with seminal works by Burns and Stalker [2], Woodward [3], Lawrence and Lorsch [4] and others, organization and...the privilege of working . It is not immediately clear how well our understanding of Contingency Theory applies to enhance the fit of organizations

  6. Family-supportive organization perceptions: validation of an abbreviated measure and theory extension.

    PubMed

    Booth, Suzanne M; Matthews, Russell A

    2012-01-01

    Although the concept of family-supportive organization perceptions has been well received in the literature, the actual construct has been relatively understudied. In the present study, we accomplish two goals. First using confirmatory factor analysis, we report on the validation of an abbreviated six-item measure of family-supportive organization perceptions that demonstrates limited measurement error. Second, we link role theory, social support resource theory, and the direct effects model of social support, to suggest that the way in which family-supportive organization perceptions affect work-family conflict is via experiences of domain overload. Contrary to the direct effects model of social support, family-supportive organization perceptions do not differentially impact work and family overload. Consistent with social support resource theory though, the effects of family-supportive organization perceptions on work-to-family and family to-work conflict are fully mediated via work and family overload (respectively). Avenues for future research incorporating family-supportive organization perceptions are also considered.

  7. An Investigation of the Advance Organizer Theory as an Effective Teaching Model.

    ERIC Educational Resources Information Center

    Downing, Agnes

    This paper advocates for the improvement of presentational methods of teaching and expository learning, based on David Ausubel's theory of Meaningful Verbal Learning and its derivative, the Advance Organizer Model of Teaching. This approach to teaching enables teachers to convey large amounts of information as meaningfully and efficiently as…

  8. Youth Purpose through the Lens of the Theory of Organizing Models of Thinking

    ERIC Educational Resources Information Center

    Arantes, Valeria; Araujo, Ulisses; Pinheiro, Viviane; Moreno Marimon, Montserrat; Sastre, Genoveva

    2017-01-01

    Purpose represents a unique opportunity for identifying and analyzing the complexity of human reasoning, considering that its constitution brings together cognitive, affective and social elements. In this article, we use the Theory of Organizing Models of Thinking (OMT), an epistemological and methodological approach based on developmental…

  9. Examining Agency Theory in Training & Development: Understanding Self-Interest Behaviors in the Organization

    ERIC Educational Resources Information Center

    Azevedo, Ross E.; Akdere, Mesut

    2011-01-01

    Agency theory has been discussed widely in the business and management literature. However, to date there has been no investigation about its utility and implications for problems in training & development. Whereas organizations are still struggling to develop and implement effective training programs, there is little emphasis on the self-interest…

  10. A Contribution to a Theory of Organizations: An Examination of Student Protest.

    ERIC Educational Resources Information Center

    Norr, James L.

    Until recently most of the research on college student protest of the 1960's has taken either a political socialization or cultural-historical perspective. The research reported here takes an organizational perspective with the expectation that an examination of student protest should contribute to a theory of organizations. Two classes of…

  11. How Youth Get Engaged: Grounded-Theory Research on Motivational Development in Organized Youth Programs

    ERIC Educational Resources Information Center

    Dawes, Nickki Pearce; Larson, Reed

    2011-01-01

    For youth to benefit from many of the developmental opportunities provided by organized programs, they need to not only attend but become psychologically engaged in program activities. This research was aimed at formulating empirically based grounded theory on the processes through which this engagement develops. Longitudinal interviews were…

  12. Innovation Diffusion: Proposal of an Organizing Theory on Which To Base Research into School Library Development.

    ERIC Educational Resources Information Center

    Knuth, Rebecca

    1997-01-01

    Discusses the appropriateness of applying diffusion theory to the study of five factors that influence school library development globally: (1) the evolution of, acceptance of, and consensus on a viable service-delivery model; (2) influence exercised by professional organizations; (3) generation of acceptable standards; (4) overt government…

  13. Differentiation-Integration Organization Theory in Fund Development Programs of Public Research Universities.

    ERIC Educational Resources Information Center

    Rao, Michael S.

    The study reported in this paper applied contingency organization theory to the environment of fund development programs in public research universities. Of particular concern was the recent emphasis of these universities on private fund development and their increased relationships with external environments. Case studies of the development…

  14. Self-Determination Theory as an Organizing Framework To Investigate Women's Physical Activity Behavior.

    ERIC Educational Resources Information Center

    Landry, Joan B.; Solmon, Melinda A.

    2002-01-01

    Explores the literature on the status of women's health behavior and the benefits of physical activity, using Self- Determination Theory (SDT) as an organizing framework and including the Health Belief Model and Transtheoretical Model in the framework. Women's physical activity behaviors are examined through the lens of SDT with the intention of…

  15. Organisms, organizations and interactions: an information theory approach to biocultural evolution.

    PubMed

    Wallace, R; Wallace, R G

    1999-08-01

    The language metaphor of theoretical biology, proposed by Waddington in 1972, provides a basis for the formal examination of how different self-reproducing structures interact in an extended evolutionary context. Such interactions have become central objects of study in fields ranging from human evolution-genes and culture-to economics-firms, markets and technology. Here we use the Shannon-McMillan Theorem, one of the fundamental asymptotic relations of probability theory, to study the 'weakest' and hence most universal, forms of interaction between generalized languages. We propose that the co-evolving gene-culture structure that permits human ultra-sociality emerged in a singular coagulation of genetic and cultural 'languages', in the general sense of the word. Human populations have since hosted series of culture-only speciations and coagulations, events that, in this formulation, do not become mired in the 'meme' concept.

  16. [Business organization theory: its potential use in the organization of the operating room].

    PubMed

    Bartz, H-J

    2005-07-01

    The paradigm of patient care in the German health system is changing. The introduction of German Diagnosis Related Groups (G-DRGs), a diagnosis-related coding system, has made process-oriented thinking increasingly important. The treatment process is viewed and managed as a whole from the admission to the discharge of the patient. The interfaces of departments and sectors are diminished. A main objective of these measures is to render patient care more cost efficient. Within the hospital, the operating room (OR) is the most expensive factor accounting for 25 - 50 % of the costs of a surgical patient and is also a bottleneck in the surgical patient care. Therefore, controlling of the perioperative treatment process is getting more and more important. Here, the business organisation theory can be a very useful tool. Especially the concepts of process organisation and process management can be applied to hospitals. Process-oriented thinking uncovers and solves typical organisational problems. Competences, responsibilities and tasks are reorganised by process orientation and the enterprise is gradually transformed to a process-oriented system. Process management includes objective-oriented controlling of the value chain of an enterprise with regard to quality, time, costs and customer satisfaction. The quality of the process is continuously improved using process-management techniques. The main advantage of process management is consistent customer orientation. Customer orientation means to be aware of the customer's needs at any time during the daily routine. The performance is therefore always directed towards current market requirements. This paper presents the basics of business organisation theory and to point out its potential use in the organisation of the OR.

  17. Organizers.

    ERIC Educational Resources Information Center

    Callison, Daniel

    2000-01-01

    Focuses on "organizers," tools or techniques that provide identification and classification along with possible relationships or connections among ideas, concepts, and issues. Discusses David Ausubel's research and ideas concerning advance organizers; the implications of Ausubel's theory to curriculum and teaching; "webbing," a…

  18. Organizers.

    ERIC Educational Resources Information Center

    Callison, Daniel

    2000-01-01

    Focuses on "organizers," tools or techniques that provide identification and classification along with possible relationships or connections among ideas, concepts, and issues. Discusses David Ausubel's research and ideas concerning advance organizers; the implications of Ausubel's theory to curriculum and teaching; "webbing," a…

  19. Improving the Reliability of Student Scores from Speeded Assessments: An Illustration of Conditional Item Response Theory Using a Computer-Administered Measure of Vocabulary

    PubMed Central

    Petscher, Yaacov; Mitchell, Alison M.; Foorman, Barbara R.

    2016-01-01

    A growing body of literature suggests that response latency, the amount of time it takes an individual to respond to an item, may be an important factor to consider when using assessment data to estimate the ability of an individual. Considering that tests of passage and list fluency are being adapted to a computer administration format, it is possible that accounting for individual differences in response times may be an increasingly feasible option to strengthen the precision of individual scores. The present research evaluated the differential reliability of scores when using classical test theory and item response theory as compared to a conditional item response model which includes response time as an item parameter. Results indicated that the precision of student ability scores increased by an average of 5 % when using the conditional item response model, with greater improvements for those who were average or high ability. Implications for measurement models of speeded assessments are discussed. PMID:27721568

  20. Compatibility between Text Mining and Qualitative Research in the Perspectives of Grounded Theory, Content Analysis, and Reliability

    ERIC Educational Resources Information Center

    Yu, Chong Ho; Jannasch-Pennell, Angel; DiGangi, Samuel

    2011-01-01

    The objective of this article is to illustrate that text mining and qualitative research are epistemologically compatible. First, like many qualitative research approaches, such as grounded theory, text mining encourages open-mindedness and discourages preconceptions. Contrary to the popular belief that text mining is a linear and fully automated…

  1. Reliability and Validity Study of the Mobile Learning Adoption Scale Developed Based on the Diffusion of Innovations Theory

    ERIC Educational Resources Information Center

    Celik, Ismail; Sahin, Ismail; Aydin, Mustafa

    2014-01-01

    In this study, a mobile learning adoption scale (MLAS) was developed on the basis of Rogers' (2003) Diffusion of Innovations Theory. The scale that was developed consists of four sections. These sections are as follows: Stages in the innovation-decision process, Types of m-learning decision, Innovativeness level and attributes of m-learning.…

  2. Reliability and Validity Study of the Mobile Learning Adoption Scale Developed Based on the Diffusion of Innovations Theory

    ERIC Educational Resources Information Center

    Celik, Ismail; Sahin, Ismail; Aydin, Mustafa

    2014-01-01

    In this study, a mobile learning adoption scale (MLAS) was developed on the basis of Rogers' (2003) Diffusion of Innovations Theory. The scale that was developed consists of four sections. These sections are as follows: Stages in the innovation-decision process, Types of m-learning decision, Innovativeness level and attributes of m-learning. There…

  3. Adequacy of Asymptotic Normal Theory in Estimating Reliability for Mastery Tests Based on the Beta-Binomial Model.

    ERIC Educational Resources Information Center

    Huynh, Huynh

    1981-01-01

    Simulated data based on five test score distributions indicate that a slight modification of the asymptotic normal theory for the estimation of the p and kappa indices in mastery testing will provide results which are in close agreement with those based on small samples from the beta-binomial distribution. (Author/BW)

  4. Estimation of reliability and dynamic property for polymeric material at high strain rate using SHPB technique and probability theory

    NASA Astrophysics Data System (ADS)

    Kim, Dong Hyeok; Lee, Ouk Sub; Kim, Hong Min; Choi, Hye Bin

    2008-11-01

    A modified Split Hopkinson Pressure Bar technique with aluminum pressure bars and a pulse shaper technique to achieve a closer impedance match between the pressure bars and the specimen materials such as hot temperature degraded POM (Poly Oxy Methylene) and PP (Poly Propylene). The more distinguishable experimental signals were obtained to evaluate the more accurate dynamic deformation behavior of materials under a high strain rate loading condition. A pulse shaping technique is introduced to reduce the non-equilibrium on the dynamic material response by modulation of the incident wave during a short period of test. This increases the rise time of the incident pulse in the SHPB experiment. For the dynamic stress strain curve obtained from SHPB experiment, the Johnson-Cook model is applied as a constitutive equation. The applicability of this constitutive equation is verified by using the probabilistic reliability estimation method. Two reliability methodologies such as the FORM and the SORM have been proposed. The limit state function(LSF) includes the Johnson-Cook model and applied stresses. The LSF in this study allows more statistical flexibility on the yield stress than a paper published before. It is found that the failure probability estimated by using the SORM is more reliable than those of the FORM/ It is also noted that the failure probability increases with increase of the applied stress. Moreover, it is also found that the parameters of Johnson-Cook model such as A and n, and the applied stress are found to affect the failure probability more severely than the other random variables according to the sensitivity analysis.

  5. Self-organization theories and environmental management: The case of South Moresby, Canada

    NASA Astrophysics Data System (ADS)

    Grzybowski, Alex G. S.; Slocombe, D. Scott

    1988-07-01

    This article presents a new approach to the analysis and management of large-scale societal problems with complex ecological, economic, and social dimensions. The approach is based on the theory of self-organizing systems—complex, open, far-from-equilibrium systems with nonlinear dynamics. A brief overview and comparison of different self-organization theories (synergetics, self-organization theory, hypercycles, and autopoiesis) is presented in order to isolate the key characteristics of such systems. The approach is used to develop an analysis of the landuse controversy in the South Moresby area of the Queen Charlotte Islands, British Columbia, Canada. Critical variables are identified for each subsystem and classified by spatial and temporal scale, and discussed in terms of information content and internal/external origin. Eradication of sea otters, introduction of black-tailed deer, impacts of large-scale clearcut logging, sustainability of the coastal forest industry, and changing relations between native peoples and governments are discussed in detail to illustrate the system dynamics of the South Moresby “sociobiophysical” system. Finally, implications of the self-organizing sociobiophysical system view for regional analysis and management are identified.

  6. Thermodynamics of organisms in the context of dynamic energy budget theory.

    PubMed

    Sousa, Tânia; Mota, Rui; Domingos, Tiago; Kooijman, S A L M

    2006-11-01

    We carry out a thermodynamic analysis to an organism. It is applicable to any type of organism because (1) it is based on a thermodynamic formalism applicable to all open thermodynamic systems and (2) uses a general model to describe the internal structure of the organism--the dynamic energy budget (DEB) model. Our results on the thermodynamics of DEB organisms are the following. (1) Thermodynamic constraints for the following types of organisms: (a) aerobic and exothermic, (b) anaerobic and exothermic, and (c) anaerobic and endothermic; showing that anaerobic organisms have a higher thermodynamic flexibility. (2) A way to compute the changes in the enthalpy and in the entropy of living biomass that accompany changes in growth rate solving the problem of evaluating the thermodynamic properties of biomass as a function of the amount of reserves. (3) Two expressions for Thornton's coefficient that explain its experimental variability and theoretically underpin its use in metabolic studies. (4) A mechanism that organisms in non-steady-state use to rid themselves of internal entropy production: "dilution of entropy production by growth." To demonstrate the practical applicability of DEB theory to quantify thermodynamic changes in organisms we use published data on Klebsiella aerogenes growing aerobically in a continuous culture. We obtain different values for molar entropies of the reserve and the structure of Klebsiella aerogenes proving that the reserve density concept of DEB theory is essential in discussions concerning (a) the relationship between organization and entropy and (b) the mechanism of storing entropy in new biomass. Additionally, our results suggest that the entropy of dead biomass is significantly different from the entropy of living biomass.

  7. Content-oriented Approach to Organization of Theories and Its Utilization

    NASA Astrophysics Data System (ADS)

    Hayashi, Yusuke; Bourdeau, Jacqueline; Mizoguch, Riichiro

    In spite of the fact that the relation between theory and practice is a foundation of scientific and technological development, the trend of increasing the gap between theory and practice accelerates in these years. The gap embraces a risk of distrust of science and technology. Ontological engineering as the content-oriented research is expected to contribute to the resolution of the gap. This paper presents the feasibility of organization of theoretical knowledge on ontological engineering and new-generation intelligent systems based on it through an application of ontological engineering in the area of learning/instruction support. This area also has the problem of the gap between theory and practice, and its resolution is strongly required. So far we proposed OMNIBUS ontology, which is a comprehensive ontology that covers different learning/instructional theories and paradigms, and SMARTIES, which is a theory-aware and standard-compliant authoring system for making learning/instructional scenarios based on OMNIBUS ontology. We believe the theory-awareness and standard-compliance bridge the gap between theory and practice because it links theories to practical use of standard technologies and enables practitioners to easily enjoy theoretical support while using standard technologies in practice. The following goals are set in order to achieve it; computers (1) understand a variety of learning/instructional theories based on the organization of them, (2) utilize the understanding for helping authors' learning/instructional scenario making and (3) make such theoretically sound scenarios interoperable within the framework of standard technologies. This paper suggests an ontological engineering solution to the achievement of these three goals. Although the evaluation is far from complete in terms of practical use, we believe that the results of this study address high-level technical challenges from the viewpoint of the current state of the art in the research area

  8. Assessing governance theory and practice in health-care organizations: a survey of UK hospices.

    PubMed

    Chambers, Naomi; Benson, Lawrence; Boyd, Alan; Girling, Jeff

    2012-05-01

    This paper sets out a theoretical framework for analyzing board governance, and describes an empirical study of corporate governance practices in a subset of non-profit organizations (hospices in the UK). It examines how practices in hospice governance compare with what is known about effective board working. We found that key strengths of hospice boards included a strong focus on the mission and the finances of the organizations, and common weaknesses included a lack of involvement in strategic matters and a lack of confidence, and some nervousness about challenging the organization on the quality of clinical care. Finally, the paper offers suggestions for theoretical development particularly in relation to board governance in non-profit organizations. It develops an engagement theory for boards which comprises a triadic proposition of high challenge, high support and strong grip.

  9. Theory of the field-effect mobility in amorphous organic transistors

    NASA Astrophysics Data System (ADS)

    Vissenberg, M. C. J. M.; Matters, M.

    1998-05-01

    The field-effect mobility in an organic thin-film transistor is studied theoretically. From a percolation model of hopping between localized states and a transistor model an analytic expression for the field-effect mobility is obtained. The theory is applied to describe the experiments by Brown et al. [Synth. Met. 88, 37 (1997)] on solution-processed amorphous organic transistors, made from a polymer (polythienylene vinylene) and from a small molecule (pentacene). Good agreement is obtained, with respect to both the gate voltage and the temperature dependence of the mobility.

  10. Assuring reliability program effectiveness.

    NASA Technical Reports Server (NTRS)

    Ball, L. W.

    1973-01-01

    An attempt is made to provide simple identification and description of techniques that have proved to be most useful either in developing a new product or in improving reliability of an established product. The first reliability task is obtaining and organizing parts failure rate data. Other tasks are parts screening, tabulation of general failure rates, preventive maintenance, prediction of new product reliability, and statistical demonstration of achieved reliability. Five principal tasks for improving reliability involve the physics of failure research, derating of internal stresses, control of external stresses, functional redundancy, and failure effects control. A final task is the training and motivation of reliability specialist engineers.

  11. Assuring reliability program effectiveness.

    NASA Technical Reports Server (NTRS)

    Ball, L. W.

    1973-01-01

    An attempt is made to provide simple identification and description of techniques that have proved to be most useful either in developing a new product or in improving reliability of an established product. The first reliability task is obtaining and organizing parts failure rate data. Other tasks are parts screening, tabulation of general failure rates, preventive maintenance, prediction of new product reliability, and statistical demonstration of achieved reliability. Five principal tasks for improving reliability involve the physics of failure research, derating of internal stresses, control of external stresses, functional redundancy, and failure effects control. A final task is the training and motivation of reliability specialist engineers.

  12. Insights into the organization of biochemical regulatory networks using graph theory analyses.

    PubMed

    Ma'ayan, Avi

    2009-02-27

    Graph theory has been a valuable mathematical modeling tool to gain insights into the topological organization of biochemical networks. There are two types of insights that may be obtained by graph theory analyses. The first provides an overview of the global organization of biochemical networks; the second uses prior knowledge to place results from multivariate experiments, such as microarray data sets, in the context of known pathways and networks to infer regulation. Using graph analyses, biochemical networks are found to be scale-free and small-world, indicating that these networks contain hubs, which are proteins that interact with many other molecules. These hubs may interact with many different types of proteins at the same time and location or at different times and locations, resulting in diverse biological responses. Groups of components in networks are organized in recurring patterns termed network motifs such as feedback and feed-forward loops. Graph analysis revealed that negative feedback loops are less common and are present mostly in proximity to the membrane, whereas positive feedback loops are highly nested in an architecture that promotes dynamical stability. Cell signaling networks have multiple pathways from some input receptors and few from others. Such topology is reminiscent of a classification system. Signaling networks display a bow-tie structure indicative of funneling information from extracellular signals and then dispatching information from a few specific central intracellular signaling nexuses. These insights show that graph theory is a valuable tool for gaining an understanding of global regulatory features of biochemical networks.

  13. Reliability analysis of the Chinese version of the Functional Assessment of Cancer Therapy - Leukemia (FACT-Leu) scale based on multivariate generalizability theory.

    PubMed

    Meng, Qiong; Yang, Zheng; Wu, Yang; Xiao, Yuanyuan; Gu, Xuezhong; Zhang, Meixia; Wan, Chonghua; Li, Xiaosong

    2017-05-04

    The Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) scale, a leukemia-specific instrument for determining the health-related quality of life (HRQOL) in patients with leukemia, had been developed and validated, but there have been no reports on the development of a simplified Chinese version of this scale. This is a new exploration to analyze the reliability of the HRQOL measurement using multivariate generalizability theory (MGT). This study aimed to develop a Chinese version of the FACT-Leu scale and evaluate its reliability using MGT to provide evidence to support the revision and improvement of this scale. The Chinese version of the FACT-Leu scale was developed by four steps: forward translation, backward translation, cultural adaptation and pilot-testing. The HRQOL was measured for eligible inpatients with leukemia using this scale to provide data. A single-facet multivariate Generalizability Study (G-study) design was demonstrated to estimate the variance-covariance components and then several Decision Studies (D-studies) with varying numbers of items were analyzed to obtain reliability coefficients and to understand how much the measurement reliability could be vary as the number of items in MGT changes. One-hundred and one eligible inpatients diagnosed with leukemia were recruited and completed the HRQOL measurement at the time of admission to the hospital. In the G-study, the variation component of the patient-item interaction was largest while the variation component of the item was the smallest for the four of five domains, except for the leukemia-specific (LEUS) domain. In the D-study, at the level of domain, the generalizability coefficients (G) and the indexes of dependability (Ф) for four of the five domains were approximately equal to or greater than 0.80 except for the Emotional Well-being (EWB) domain (>0.70 but <0.80). For the overall scale, the composite G and composite Ф coefficients were greater than 0.90. Based on the G

  14. Geminate electron-hole recombination in organic photovoltaic cells. A semi-empirical theory

    NASA Astrophysics Data System (ADS)

    Wojcik, Mariusz; Nowak, Artur; Seki, Kazuhiko

    2017-02-01

    We propose a semi-empirical theory which describes the geminate electron-hole separation probability in both homogeneous systems and donor-acceptor heterojunction systems applicable in organic photovoltaics. The theory is based on the results of extensive simulation calculations, which were carried out using various lattice models of the medium and different charge-carrier hopping mechanisms, over the parameter ranges typical for organic solar cells. It is found that the electron-hole separation probability can be conveniently described in terms of measurable parameters by a formula whose functional form is derived from the existing recombination theories, and which contains only one empirical parameter. For homogeneous systems, this parameter is determined by the structure of the medium and only weakly depends on the charge-carrier hopping mechanism. In the case of donor-acceptor heterojunction systems, this empirical parameter shows a simple power-law dependence on the product of the dielectric constant and inter-molecular contact distance. We also study the effect of heterojunction structure on the electron-hole separation probability and show that this probability decreases with increasing roughness of the heterojunction. By analyzing the simulation results obtained for systems under the influence of an external electric field, we find that the field effect on the electron-hole separation probability in donor-acceptor heterojunction systems is weaker than in homogeneous systems. We also describe this field effect by a convenient empirical formula.

  15. Geminate electron-hole recombination in organic photovoltaic cells. A semi-empirical theory.

    PubMed

    Wojcik, Mariusz; Nowak, Artur; Seki, Kazuhiko

    2017-02-07

    We propose a semi-empirical theory which describes the geminate electron-hole separation probability in both homogeneous systems and donor-acceptor heterojunction systems applicable in organic photovoltaics. The theory is based on the results of extensive simulation calculations, which were carried out using various lattice models of the medium and different charge-carrier hopping mechanisms, over the parameter ranges typical for organic solar cells. It is found that the electron-hole separation probability can be conveniently described in terms of measurable parameters by a formula whose functional form is derived from the existing recombination theories, and which contains only one empirical parameter. For homogeneous systems, this parameter is determined by the structure of the medium and only weakly depends on the charge-carrier hopping mechanism. In the case of donor-acceptor heterojunction systems, this empirical parameter shows a simple power-law dependence on the product of the dielectric constant and inter-molecular contact distance. We also study the effect of heterojunction structure on the electron-hole separation probability and show that this probability decreases with increasing roughness of the heterojunction. By analyzing the simulation results obtained for systems under the influence of an external electric field, we find that the field effect on the electron-hole separation probability in donor-acceptor heterojunction systems is weaker than in homogeneous systems. We also describe this field effect by a convenient empirical formula.

  16. VLSI reliability

    SciTech Connect

    Sabnis, A.G. )

    1990-01-01

    This book presents major topics in IC reliability from basic concepts to packaging issues. Other topics covered include failure analysis techniques, radiation effects, and reliability assurance and qualification. This book offers insight into the practical aspects of VLSI reliability.

  17. Establishing validity and reliability of an instrument using the theory of planned behavior to predict middle school student obesity-related actions.

    PubMed

    Ickes, Melinda J; Sharma, Manoj

    Childhood obesity is of concern to many health professionals, parents, teachers, and school administrators because of the negative impact on the child's physical, psychological, and behavioral health. Lack of structured monitoring and evaluation has hindered the development of an evidence base to disseminate best practices in childhood obesity prevention. The purpose of this study was to develop a valid and reliable instrument which affirmed the constructs of the Theory of Planned Behavior in relation to nutrition and physical activity behaviors related to childhood obesity. A convenience sample of 242 students participated in the validation of the 129-item instrument, which was administered during class time, and read to students to increase response rate. Confirmatory factor analysis established instrument validity, with one factor present for each behavior, and factor loadings greater than 0.32. Reliability and test-retest coefficients achieved apriori criteria of 0.70. Truly learning how to gauge nutrition and physical activity levels in children and adolescents has proved to be difficult, yet it is imperative to understand the relationship of the proposed potentially modifiable behaviors and childhood obesity.

  18. Testing feasibility and reliability of a set of quality indicators to evaluate the organization of palliative care across Europe: a pilot study in 25 countries.

    PubMed

    Woitha, Kathrin; Hasselaar, Jeroen; van Beek, Karen; Ahmed, Nisar; Jaspers, Birgit; Hendriks, Jan C M; Radbruch, Lukas; Vissers, Kris; Engels, Yvonne

    2015-02-01

    A well-organized palliative care service is a prerequisite for offering good palliative care. Reliable and feasible quality indicators are needed to monitor the quality of their organization. To test feasibility and reliability of a previously developed set of quality indicators in settings and services that provide palliative care across Europe. A total of 38 quality indicators, applicable in all types of settings, rated in a RAND Delphi process, and operationalized into 38 yes/no questions, were used. Descriptives statistics, factor and reliability analyses, analysis of variance, and chi-square analyses were used. Cross-sectional online survey. Questionnaires were sent to representatives of 217 palliative care settings in 25 countries. Included settings were hospices, inpatient dedicated palliative care beds, palliative care outpatient clinics, palliative care units, day care centers for palliative care, palliative care home support teams, inpatient palliative care support teams, care homes, and nursing homes. All invited 25 European Association of Palliative Care countries took part. In total, 107 out of 217 participants responded (57%). The quality indicators were reduced to four coherent sub-scales, being "equipment and continuity of care," "structured documentation of essential palliative care elements in the medical record," "training and appraisal of personnel," and "availability of controlled drugs." No significant differences in quality criteria between the different types of settings and services were identified. The set of quality indicators appeared to measure four reliable domains that assess the organization of different palliative care settings. It can be used as a starting point for quality improvement activities. © The Author(s) 2015.

  19. Using organization theory to understand the determinants of effective implementation of worksite health promotion programs.

    PubMed

    Weiner, Bryan J; Lewis, Megan A; Linnan, Laura A

    2009-04-01

    The field of worksite health promotion has moved toward the development and testing of comprehensive programs that target health behaviors with interventions operating at multiple levels of influence. Yet, observational and process evaluation studies indicate that such programs are challenging for worksites to implement effectively. Research has identified several organizational factors that promote or inhibit effective implementation of comprehensive worksite health promotion programs. However, no integrated theory of implementation has emerged from this research. This article describes a theory of the organizational determinants of effective implementation of comprehensive worksite health promotion programs. The model is adapted from theory and research on the implementation of complex innovations in manufacturing, education and health care settings. The article uses the Working Well Trial to illustrate the model's theoretical constructs. Although the article focuses on comprehensive worksite health promotion programs, the conceptual model may also apply to other types of complex health promotion programs. An organization-level theory of the determinants of effective implementation of worksite health promotion programs.

  20. The Mosaic Theory Revisited: Common Molecular Mechanisms Coordinating Diverse Organ and Cellular Events in Hypertension

    PubMed Central

    Harrison, David G.

    2012-01-01

    Over 60 years ago, Dr. Irvine Page proposed the Mosaic Theory of hypertension, which states that many factors, including genetics, environment, adaptive, neural, mechanical and hormonal perturbations interdigitate to raise blood pressure. In the past two decades, it has become clear that common molecular and cellular events in various organs underlie many features of the Mosaic Theory. Two of these are the production of reactive oxygen species (ROS) and inflammation. These factors increase neuronal firing in specific brain centers, increase sympathetic outflow, alter vascular tone and morphology and promote sodium retention in the kidney. Moreover, factors such as genetics and environment contribute to oxidant generation and inflammation. Other common cellular signals, including calcium signaling and endoplasmic reticulum stress are similarly perturbed in different cells in hypertension and contribute to components of Dr. Page’s theory. Thus, Dr. Page’s Mosaic Theory formed a framework for future studies of molecular and cellular signals in the context of hypertension, and has greatly aided our understanding of this complex disease. PMID:23321405

  1. Are the Somatic Mutation and Tissue Organization Field Theories of Carcinogenesis Incompatible?

    PubMed Central

    Rosenfeld, Simon

    2013-01-01

    Two drastically different approaches to understanding the forces driving carcinogenesis have crystallized through years of research. These are the somatic mutation theory (SMT) and the tissue organization field theory (TOFT). The essence of SMT is that cancer is derived from a single somatic cell that has successively accumulated multiple DNA mutations, and that those mutations occur on genes which control cell proliferation and cell cycle. Thus, according to SMT, neoplastic lesions are the results of DNA-level events. Conversely, according to TOFT, carcinogenesis is primarily a problem of tissue organization: carcinogenic agents destroy the normal tissue architecture thus disrupting cell-to-cell signaling and compromising genomic integrity. Hence, in TOFT the DNA mutations are the effect, and not the cause, of the tissue-level events. Cardinal importance of successful resolution of the TOFT versus SMT controversy dwells in the fact that, according to SMT, cancer is a unidirectional and mostly irreversible disease; whereas, according to TOFT, it is curable and reversible. In this paper, our goal is to outline a plausible scenario in which TOFT and SMT can be reconciled using the framework and concepts of the self-organized criticality (SOC), the principle proven to be extremely fruitful in a wide range of disciplines pertaining to natural phenomena, to biological communities, to large-scale social developments, to technological networks, and to many other subjects of research. PMID:24324325

  2. Predicting behavioural responses to novel organisms: state-dependent detection theory.

    PubMed

    Trimmer, Pete C; Ehlman, Sean M; Sih, Andrew

    2017-01-25

    Human activity alters natural habitats for many species. Understanding variation in animals' behavioural responses to these changing environments is critical. We show how signal detection theory can be used within a wider framework of state-dependent modelling to predict behavioural responses to a major environmental change: novel, exotic species. We allow thresholds for action to be a function of reserves, and demonstrate how optimal thresholds can be calculated. We term this framework 'state-dependent detection theory' (SDDT). We focus on behavioural and fitness outcomes when animals continue to use formerly adaptive thresholds following environmental change. In a simple example, we show that exposure to novel animals which appear dangerous-but are actually safe-(e.g. ecotourists) can have catastrophic consequences for 'prey' (organisms that respond as if the new organisms are predators), significantly increasing mortality even when the novel species is not predatory. SDDT also reveals that the effect on reproduction can be greater than the effect on lifespan. We investigate factors that influence the effect of novel organisms, and address the potential for behavioural adjustments (via evolution or learning) to recover otherwise reduced fitness. Although effects of environmental change are often difficult to predict, we suggest that SDDT provides a useful route ahead.

  3. Are the somatic mutation and tissue organization field theories of carcinogenesis incompatible?

    PubMed

    Rosenfeld, Simon

    2013-01-01

    Two drastically different approaches to understanding the forces driving carcinogenesis have crystallized through years of research. These are the somatic mutation theory (SMT) and the tissue organization field theory (TOFT). The essence of SMT is that cancer is derived from a single somatic cell that has successively accumulated multiple DNA mutations, and that those mutations occur on genes which control cell proliferation and cell cycle. Thus, according to SMT, neoplastic lesions are the results of DNA-level events. Conversely, according to TOFT, carcinogenesis is primarily a problem of tissue organization: carcinogenic agents destroy the normal tissue architecture thus disrupting cell-to-cell signaling and compromising genomic integrity. Hence, in TOFT the DNA mutations are the effect, and not the cause, of the tissue-level events. Cardinal importance of successful resolution of the TOFT versus SMT controversy dwells in the fact that, according to SMT, cancer is a unidirectional and mostly irreversible disease; whereas, according to TOFT, it is curable and reversible. In this paper, our goal is to outline a plausible scenario in which TOFT and SMT can be reconciled using the framework and concepts of the self-organized criticality (SOC), the principle proven to be extremely fruitful in a wide range of disciplines pertaining to natural phenomena, to biological communities, to large-scale social developments, to technological networks, and to many other subjects of research.

  4. Charge carriers and excitons transport in an organic solar cell-theory and simulation

    NASA Astrophysics Data System (ADS)

    Shahini, Ali.; Abbasian, Karim.

    2012-08-01

    An organic solar cell model is developed that consists of both excitonic and classical bipolar aspects of solar cells. In order to achieve this goal, the photon recycling term is imported into the equations to connect the Shockley-Queisser theory and the classical diode theory. This model for excitonic and classical bipolar solar cells can describe the combined transport and interaction of electrons, holes and excitons. For high mobilities this model reproduces the Shockley Queisser efficiency limit. We show how varying the respective mobilities of the different species changes the operation mode of the solar cell path between excitonic and bipolar. Then, the effect of conduction band offset on transport will be described in this paper. Finally, validity of reciprocity theorem between quantum efficiency and electroluminescence in this model will be discussed.

  5. Decision-making regarding organ donation in Korean adults: A grounded-theory study.

    PubMed

    Yeun, Eun Ja; Kwon, Young Mi; Kim, Jung A

    2015-06-01

    The aim of this study was to identify the hidden patterns of behavior leading toward the decision to donate organs. Thirteen registrants at the Association for Organ Sharing in Korea were recruited. Data were collected using in-depth interview and the interview transcripts were analyzed using Glaserian grounded-theory methodology. The main problem of participants was "body attachment" and the core category (management process) was determined to be "pursuing life." The theme consisted of four phases, which were: "hesitating," "investigating," "releasing," and "re-discovering. " Therefore, to increase organ donations, it is important to find a strategy that will create positive attitudes about organ donation through education and public relations. These results explain and provide a deeper understanding of the main problem that Korean people have about organ donation and their management of decision-making processes. These findings can help care providers to facilitate the decision-making process and respond to public needs while taking into account the sociocultural context within which decisions are made. © 2014 Wiley Publishing Asia Pty Ltd.

  6. African American Organ Donor Registration: A Mixed Methods Design using the Theory of Planned Behavior

    PubMed Central

    DuBay, Derek A.; Ivankova, Nataliya; Herby, Ivan; Wynn, Theresa A.; Kohler, Connie; Berry, Beverly; Foushee, Herman; Carson, April; Redden, David T.; Holt, Cheryl; Siminoff, Laura; Fouad, Mona; Martin, Michelle Y.

    2015-01-01

    Context A large racial disparity exists in organ donation. Objective The purpose of this study was to identify factors associated with becoming a registered organ donor in among African Americans in Alabama. Methods The study utilized a concurrent mixed methods design guided by the Theory of Planned Behavior to analyze African American’s decisions to become a registered organ donor using both qualitative (focus groups) and quantitative (survey) methods. Results The sample consisted of 22 registered organ donors (ROD) and 65 non-registered participants (NRP) from six focus groups completed in urban (n=3) and rural (n=3) areas. Participants emphasized the importance of the autonomy to make one’s own organ donation decision and have this decision honored posthumously. One novel barrier to becoming a ROD was the perception that organs from African Americans were often unusable due to high prevalence of chronic medical conditions such as diabetes and hypertension. Another novel theme discussed as an advantage to becoming a ROD was the subsequent motivation to take responsibility for one’s health. Family and friends were the most common groups of persons identified as approving and disapproving of the decision to become a ROD. The most common facilitator to becoming a ROD was information, while fear and the lack of information were the most common barriers. In contrast, religious beliefs, mistrust and social justice themes were infrequently referenced as barriers to becoming a ROD. Discussion Findings from this study may be useful for prioritizing organ donation community-based educational interventions in campaigns to increase donor registration. PMID:25193729

  7. Ab initio theory of charge-carrier conduction in ultrapure organic crystals

    NASA Astrophysics Data System (ADS)

    Hannewald, K.; Bobbert, P. A.

    2004-08-01

    We present an ab initio description of charge-carrier mobilities in organic molecular crystals of high purity. Our approach is based on Holstein's original concept of small-polaron bands but generalized with respect to the inclusion of nonlocal electron-phonon coupling. By means of an explicit expression for the mobilities as a function of temperature in combination with ab initio calculations of the material parameters, we demonstrate the predictive power of our theory by applying it to naphthalene. The results show a good qualitative agreement with experiment and provide insight into the difference between electron and hole mobilities as well as their peculiar algebraic and anisotropic temperature dependencies.

  8. Reliable semiclassical computations in QCD

    NASA Astrophysics Data System (ADS)

    Dine, Michael; Festuccia, Guido; Pack, Lawrence; Wu, Weitao

    2010-09-01

    We revisit the question of whether or not one can perform reliable semiclassical QCD computations at zero temperature. We study correlation functions with no perturbative contributions, and organize the problem by means of the operator product expansion, establishing a precise criterion for the validity of a semiclassical calculation. For Nf>N, a systematic computation is possible; for Nftheory computations in the chiral limit.

  9. Modelling energy level alignment at organic interfaces and density functional theory.

    PubMed

    Flores, F; Ortega, J; Vázquez, H

    2009-10-21

    A review of our theoretical understanding of the band alignment at organic interfaces is presented with particular emphasis on the metal/organic (MO) case. The unified IDIS (induced density of interface states) and the ICT (integer charge transfer) models are reviewed and shown to describe qualitatively and semiquantitatively the barrier height formation at those interfaces. The IDIS model, governed by the organic CNL (charge neutrality level) and the interface screening includes: (a) charge transfer across the interface; (b) the "pillow" (or Pauli) effect associated with the compression of the metal wavefunction tails; and (c) the molecular dipoles. We argue that the ICT-model can be described as a limiting case of the unified IDIS-model for weak interface screening. For a fully quantitative understanding of the band alignment at organic interfaces, use of DFT (density functional theory) or quantum chemistry methods is highly desirable. In this Perspective review, we concentrate our discussion on DFT and show that conventional LDA or GGA calculations are limited by the "energy gap problem of the organic materials", because the LDA (or GGA) Kohn-Sham energy levels have to be corrected by the self-interaction energy of the corresponding wavefunction, to provide the appropriate molecule transport energy gap. Image potential and polarization effects at MO interfaces tend to cancel these self-interaction corrections; in particular, we show that for organic molecules lying flat on Cu and Ag, these cancellations are so strong that we can rely on conventional DFT to calculate their interface properties. For Au, however, the cancellations are weaker making it necessary to go beyond conventional DFT. We discuss several alternatives beyond conventional LDA or GGA. The most accurate approach is the well-known GW-technique, but its use is limited by its high demanding computer time. In a very simple approach one can combine conventional DFT with a "scissor" operator which

  10. The Mochi project: a field theory approach to plasma dynamics and self-organization

    NASA Astrophysics Data System (ADS)

    You, Setthivoine; von der Linden, Jens; Lavine, Eric Sander; Card, Alexander; Carroll, Evan

    2016-10-01

    The Mochi project is designed to study the interaction between plasma flows and magnetic fields from the point-of-view of canonical flux tubes. The Mochi Labjet experiment is being commissioned after achieving first plasma. Analytical and numerical tools are being developed to visualize canonical flux tubes. One analytical tool described here is a field theory approach to plasma dynamics and self-organization. A redefinition of the Lagrangian of a multi-particle system in fields reformulates the single-particle, kinetic, and fluid equations governing fluid and plasma dynamics as a single set of generalized Maxwell's equations and Ohm's law for canonical force-fields. The Lagrangian includes new terms representing the coupling between the motion of particle distributions, between distributions and electromagnetic fields, with relativistic contributions. The formulation shows that the concepts of self-organization and canonical helicity transport are applicable across single-particle, kinetic, and fluid regimes, at classical and relativistic scales. The theory gives the basis for comparing canonical helicity change to energy change in general systems. This work is supported by by US DOE Grant DE-SC0010340.

  11. Benchmarking DFT and semi-empirical methods for a reliable and cost-efficient computational screening of benzofulvene derivatives as donor materials for small-molecule organic solar cells

    NASA Astrophysics Data System (ADS)

    Tortorella, Sara; Mastropasqua Talamo, Maurizio; Cardone, Antonio; Pastore, Mariachiara; De Angelis, Filippo

    2016-02-01

    A systematic computational investigation on the optical properties of a group of novel benzofulvene derivatives (Martinelli 2014 Org. Lett. 16 3424-7), proposed as possible donor materials in small molecule organic photovoltaic (smOPV) devices, is presented. A benchmark evaluation against experimental results on the accuracy of different exchange and correlation functionals and semi-empirical methods in predicting both reliable ground state equilibrium geometries and electronic absorption spectra is carried out. The benchmark of the geometry optimization level indicated that the best agreement with x-ray data is achieved by using the B3LYP functional. Concerning the optical gap prediction, we found that, among the employed functionals, MPW1K provides the most accurate excitation energies over the entire set of benzofulvenes. Similarly reliable results were also obtained for range-separated hybrid functionals (CAM-B3LYP and wB97XD) and for global hybrid methods incorporating a large amount of non-local exchange (M06-2X and M06-HF). Density functional theory (DFT) hybrids with a moderate (about 20-30%) extent of Hartree-Fock exchange (HFexc) (PBE0, B3LYP and M06) were also found to deliver HOMO-LUMO energy gaps which compare well with the experimental absorption maxima, thus representing a valuable alternative for a prompt and predictive estimation of the optical gap. The possibility of using completely semi-empirical approaches (AM1/ZINDO) is also discussed.

  12. Firm Size, a Self-Organized Critical Phenomenon: Evidence from the Dynamical Systems Theory

    NASA Astrophysics Data System (ADS)

    Chandra, Akhilesh

    This research draws upon a recent innovation in the dynamical systems literature called the theory of self -organized criticality (SOC) (Bak, Tang, and Wiesenfeld 1988) to develop a computational model of a firm's size by relating its internal and the external sub-systems. As a holistic paradigm, the theory of SOC implies that a firm as a composite system of many degrees of freedom naturally evolves to a critical state in which a minor event starts a chain reaction that can affect either a part or the system as a whole. Thus, the global features of a firm cannot be understood by analyzing its individual parts separately. The causal framework builds upon a constant capital resource to support a volume of production at the existing level of efficiency. The critical size is defined as the production level at which the average product of a firm's factors of production attains its maximum value. The non -linearity is inferred by a change in the nature of relations at the border of criticality, between size and the two performance variables, viz., the operating efficiency and the financial efficiency. The effect of breaching the critical size is examined on the stock price reactions. Consistent with the theory of SOC, it is hypothesized that the temporal response of a firm breaching the level of critical size should behave as a flicker noise (1/f) process. The flicker noise is characterized by correlations extended over a wide range of time scales, indicating some sort of cooperative effect among a firm's degrees of freedom. It is further hypothesized that a firm's size evolves to a spatial structure with scale-invariant, self-similar (fractal) properties. The system is said to be self-organized inasmuch as it naturally evolves to the state of criticality without any detailed specifications of the initial conditions. In this respect, the critical state is an attractor of the firm's dynamics. Another set of hypotheses examines the relations between the size and the

  13. The higher disinfectant resistance of nosocomial isolates of Klebsiella oxytoca: how reliable are indicator organisms in disinfectant testing?

    PubMed

    Gebel, J; Sonntag, H-G; Werner, H-P; Vacata, V; Exner, M; Kistemann, T

    2002-04-01

    The Children's Clinic in Giessen, Germany recently reported several severe infections with Klebsiella oxytoca resulting in deaths of two neonates. The putative source of the infections was a contaminated infusion solution. The resistance to disinfectant of the K. oxytoca isolates was investigated in three independent laboratories and was indeed found to be significantly increased. Comparative tests with standard strains of K. oxytoca and other recommended bacterial surrogates showed the disinfection procedures used were fully effective. The higher resistance of the nosocomial isolates may have developed due to improper handling and storage of the cleaning utensils. This report describes the events and draws conclusions concerning the use of disinfectants, the treatment of cleaning utensils, the reliability of procedures for testing disinfectants, and suggests additional measures.

  14. Did Geomagnetic Activity Challenge Electric Power Reliability During Solar Cycle 23? Evidence from the PJM Regional Transmission Organization in North America

    NASA Technical Reports Server (NTRS)

    Forbes, Kevin F.; Cyr, Chris St

    2012-01-01

    During solar cycle 22, a very intense geomagnetic storm on 13 March 1989 contributed to the collapse of the Hydro-Quebec power system in Canada. This event clearly demonstrated that geomagnetic storms have the potential to lead to blackouts. This paper addresses whether geomagnetic activity challenged power system reliability during solar cycle 23. Operations by PJM Interconnection, LLC (hereafter PJM), a regional transmission organization in North America, are examined over the period 1 April 2002 through 30 April 2004. During this time PJM coordinated the movement of wholesale electricity in all or parts of Delaware, Maryland, New Jersey, Ohio, Pennsylvania, Virginia, West Virginia, and the District of Columbia in the United States. We examine the relationship between a proxy of geomagnetically induced currents (GICs) and a metric of challenged reliability. In this study, GICs are proxied using magnetometer data from a geomagnetic observatory located just outside the PJM control area. The metric of challenged reliability is the incidence of out-of-economic-merit order dispatching due to adverse reactive power conditions. The statistical methods employed make it possible to disentangle the effects of GICs on power system operations from purely terrestrial factors. The results of the analysis indicate that geomagnetic activity can significantly increase the likelihood that the system operator will dispatch generating units based on system stability considerations rather than economic merit.

  15. High reliable and stable organic field-effect transistor nonvolatile memory with a poly(4-vinyl phenol) charge trapping layer based on a pn-heterojunction active layer

    SciTech Connect

    Xiang, Lanyi; Ying, Jun; Han, Jinhua; Zhang, Letian E-mail: wwei99@jlu.edu.cn; Wang, Wei E-mail: wwei99@jlu.edu.cn

    2016-04-25

    In this letter, we demonstrate a high reliable and stable organic field-effect transistor (OFET) based nonvolatile memory (NVM) with a polymer poly(4-vinyl phenol) (PVP) as the charge trapping layer. In the unipolar OFETs, the inreversible shifts of the turn-on voltage (V{sub on}) and severe degradation of the memory window (ΔV{sub on}) at programming (P) and erasing (E) voltages, respectively, block their application in NVMs. The obstacle is overcome by using a pn-heterojunction as the active layer in the OFET memory, which supplied a holes and electrons accumulating channel at the supplied P and E voltages, respectively. Both holes and electrons transferring from the channels to PVP layer and overwriting the trapped charges with an opposite polarity result in the reliable bidirectional shifts of V{sub on} at P and E voltages, respectively. The heterojunction OFET exhibits excellent nonvolatile memory characteristics, with a large ΔV{sub on} of 8.5 V, desired reading (R) voltage at 0 V, reliable P/R/E/R dynamic endurance over 100 cycles and a long retention time over 10 years.

  16. Using Ontological Engineering to Organize Learning/Instructional Theories and Build a Theory-Aware Authoring System

    ERIC Educational Resources Information Center

    Hayashi, Yusuke; Bourdeau, Jacqueline; Mizoguchi, Riichiro

    2009-01-01

    This paper describes the achievements of an innovative eight-year research program first introduced in Mizoguchi and Bourdeau (2000), which was aimed at building a theory-aware authoring system by using ontological engineering. To date, we have proposed OMNIBUS, an ontology that comprehensively covers different learning/instructional theories and…

  17. Using Ontological Engineering to Organize Learning/Instructional Theories and Build a Theory-Aware Authoring System

    ERIC Educational Resources Information Center

    Hayashi, Yusuke; Bourdeau, Jacqueline; Mizoguchi, Riichiro

    2009-01-01

    This paper describes the achievements of an innovative eight-year research program first introduced in Mizoguchi and Bourdeau (2000), which was aimed at building a theory-aware authoring system by using ontological engineering. To date, we have proposed OMNIBUS, an ontology that comprehensively covers different learning/instructional theories and…

  18. The core of after death care in relation to organ donation - a grounded theory study.

    PubMed

    Forsberg, Anna; Flodén, Anne; Lennerling, Annette; Karlsson, Veronika; Nilsson, Madeleine; Fridh, Isabell

    2014-10-01

    The aim of this study was to investigate how intensive and critical care nurses experience and deal with after death care i.e. the period from notification of a possible brain dead person, and thereby a possible organ donor, to the time of post-mortem farewell. Grounded theory, based on Charmaz' framework, was used to explore what characterises the ICU-nurses concerns during the process of after death and how they handle it. Data was collected from open-ended interviews. The core category: achieving a basis for organ donation through dignified and respectful care of the deceased person and the close relatives highlights the main concern of the 29 informants. This concern is categorised into four main areas: safeguarding the dignity of the deceased person, respecting the relatives, dignified and respectful care, enabling a dignified farewell. After death care requires the provision of intense, technical, medical and nursing interventions to enable organ donation from a deceased person. It is achieved by extensive nursing efforts to preserve and safeguard the dignity of and respect for the deceased person and the close relatives, within an atmosphere of peace and tranquillity. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Investigation of Multiconfigurational Short-Range Density Functional Theory for Electronic Excitations in Organic Molecules.

    PubMed

    Hubert, Mickaël; Hedegård, Erik D; Jensen, Hans Jørgen Aa

    2016-05-10

    Computational methods that can accurately and effectively predict all types of electronic excitations for any molecular system are missing in the toolbox of the computational chemist. Although various Kohn-Sham density-functional methods (KS-DFT) fulfill this aim in some cases, they become inadequate when the molecule has near-degeneracies and/or low-lying double-excited states. To address these issues we have recently proposed multiconfiguration short-range density-functional theory-MC-srDFT-as a new tool in the toolbox. While initial applications for systems with multireference character and double excitations have been promising, it is nevertheless important that the accuracy of MC-srDFT is at least comparable to the best KS-DFT methods also for organic molecules that are typically of single-reference character. In this paper we therefore systematically investigate the performance of MC-srDFT for a selected benchmark set of electronic excitations of organic molecules, covering the most common types of organic chromophores. This investigation confirms the expectation that the MC-srDFT method is accurate for a broad range of excitations and comparable to accurate wave function methods such as CASPT2, NEVPT2, and the coupled cluster based CC2 and CC3.

  20. Precise segmentation of multiple organs in CT volumes using learning-based approach and information theory.

    PubMed

    Lu, Chao; Zheng, Yefeng; Birkbeck, Neil; Zhang, Jingdan; Kohlberger, Timo; Tietjen, Christian; Boettger, Thomas; Duncan, James S; Zhou, S Kevin

    2012-01-01

    In this paper, we present a novel method by incorporating information theory into the learning-based approach for automatic and accurate pelvic organ segmentation (including the prostate, bladder and rectum). We target 3D CT volumes that are generated using different scanning protocols (e.g., contrast and non-contrast, with and without implant in the prostate, various resolution and position), and the volumes come from largely diverse sources (e.g., diseased in different organs). Three key ingredients are combined to solve this challenging segmentation problem. First, marginal space learning (MSL) is applied to efficiently and effectively localize the multiple organs in the largely diverse CT volumes. Second, learning techniques, steerable features, are applied for robust boundary detection. This enables handling of highly heterogeneous texture pattern. Third, a novel information theoretic scheme is incorporated into the boundary inference process. The incorporation of the Jensen-Shannon divergence further drives the mesh to the best fit of the image, thus improves the segmentation performance. The proposed approach is tested on a challenging dataset containing 188 volumes from diverse sources. Our approach not only produces excellent segmentation accuracy, but also runs about eighty times faster than previous state-of-the-art solutions. The proposed method can be applied to CT images to provide visual guidance to physicians during the computer-aided diagnosis, treatment planning and image-guided radiotherapy to treat cancers in pelvic region.

  1. Adsorptive desulfurization with metal-organic frameworks: A density functional theory investigation

    NASA Astrophysics Data System (ADS)

    Chen, Zhiping; Ling, Lixia; Wang, Baojun; Fan, Huiling; Shangguan, Ju; Mi, Jie

    2016-11-01

    The contribution of each fragment of metal-organic frameworks (MOFs) to the adsorption of sulfur compounds were investigated using density functional theory (DFT). The involved sulfur compounds are dimethyl sulfide (CH3SCH3), ethyl mercaptan (CH3CH2SH) and hydrogen sulfide (H2S). MOFs with different organic ligands (NH2-BDC, BDC and NDC), metal centers structures (M, M-M and M3O) and metal ions (Zn, Cu and Fe) were used to study their effects on sulfur species adsorption. The results revealed that, MOFs with coordinatively unsaturated sites (CUS) have the strongest binding strength with sulfur compounds, MOFs with NH2-BDC substituent group ligand comes second, followed by that with saturated metal center, and the organic ligands without substituent group has the weakest adsorption strength. Moreover, it was also found that, among different metal ions (Fe, Zn and Cu), MOFs with unsaturated Fe has the strongest adsorption strength for sulfur compounds. These results are consistent with our previous experimental observations, and therefore provide insights on the better design of MOFs for desulfurization application.

  2. Reliability as a Measurement Design Effect

    ERIC Educational Resources Information Center

    Adams, Raymond J.

    2005-01-01

    Test reliability is a concept central to classical test theory and it is commonly stated as a requirement that a test attain a certain level of reliability before it be considered of sufficient quality for practical use. This article discusses the role of reliability in item response theory, and in particular the role of reliability in contexts…

  3. 18 CFR 39.11 - Reliability reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Reliability reports. 39... RELIABILITY ORGANIZATION; AND PROCEDURES FOR THE ESTABLISHMENT, APPROVAL, AND ENFORCEMENT OF ELECTRIC RELIABILITY STANDARDS § 39.11 Reliability reports. (a) The Electric Reliability Organization shall...

  4. Within-day test-retest reliability of the Timed Up & Go test in patients with advanced chronic organ failure.

    PubMed

    Mesquita, Rafael; Janssen, Daisy J A; Wouters, Emiel F M; Schols, Jos M G A; Pitta, Fabio; Spruit, Martijn A

    2013-11-01

    To investigate the within-day test-retest reliability of the Timed Up & Go (TUG) test in patients with advanced chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), and chronic renal failure (CRF). Cross-sectional. Patients' home environment. Subjects (N=235, 64% men; median age, 70y [interquartile range, 61-77y]; median body mass index, 25.6kg/m(2) [interquartile range, 22.8-29.4kg/m(2)]) with advanced COPD (n=95), CHF (n=68), or CRF (n=72). Not applicable. Time to complete the TUG test. Three trials were performed on the same day and by the same assessors. The intraclass correlation coefficient (ICC), kappa coefficient, standard error of measurement, and absolute and relative minimal detectable change (MDC) values were calculated. Good agreement was observed, in general, for both the total sample and subgroups (COPD, CHF, CRF), with ICC values ranging from .85 to .98, and kappa coefficients from .49 to 1.00. However, statistical improvement occurred in the total sample from the first to the second trial with large limits of agreement (mean difference, -.97s; 95% confidence interval, 3.00 to -4.94s; P<.01). The third trial added little or no information to the first 2 trials. For the total sample, a standard error of measurement value of approximately 1.6 seconds, an absolute value of MDC at the 95% confidence level (MDC95%) of approximately 4.5 seconds, and a relative value of MDC at the 95% confidence level (MDC95%%) of approximately 35% were found between the first 2 trials, with similar values found for the subgroups. The TUG test is reliable in patients with advanced COPD, CHF, or CRF after 2 trials. Values of standard error of measurement and MDC may be used in daily clinical practice with these populations to define what is expected and what represents true change in repeated measures. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  5. Investigating the self-organization of debris flows: theory, modelling, and empirical work

    NASA Astrophysics Data System (ADS)

    von Elverfeldt, Kirsten; Keiler, Margreth; Elmenreich, Wilfried; Fehárvári, István; Zhevzhyk, Sergii

    2014-05-01

    Here we present the conceptual framework of an interdisciplinary project on the theory, empirics, and modelling of the self-organisation mechanisms within debris flows. Despite the fact that debris flows are causing severe damages in mountainous regions such as the Alps, the process behaviour of debris flows is still not well understood. This is mainly due to the process dynamics of debris flows: Erosion and material entrainment are essential for their destructive power, and because of this destructiveness it is nearly impossible to measure and observe these mechanisms in action. Hence, the interactions between channel bed and debris flow remain largely unknown whilst this knowledge is crucial for the understanding of debris flow behaviour. Furthermore, while these internal parameter interactions are changing during an event, they are at the same time governing the temporal and spatial evolution of a given event. This project aims at answering some of these unknowns by means of bringing theory, empirical work, and modelling of debris flows together. It especially aims at explaining why process types are switching along the flow path during an event, e.g. the change from a debris flow to a hyperconcentrated flow and back. A second focus is the question of why debris flows sometimes exhibit strong erosion and sediment mobilisation during an event and at other times they do not. A promising theoretical framework for the analysis of these observations is that of self-organizing systems, and especially Haken's theory of synergetics. Synergetics is an interdisciplinary theory of open systems that are characterized by many individual, yet interacting parts, resulting in spatio-temporal structures. We hypothesize that debris flows can successfully be analysed within this theoretical framework. In order to test this hypothesis, an innovative modelling approach is chosen in combination with detailed field work. In self-organising systems the interactions of the system

  6. Making Reliability Arguments in Classrooms

    ERIC Educational Resources Information Center

    Parkes, Jay; Giron, Tilia

    2006-01-01

    Reliability methodology needs to evolve as validity has done into an argument supported by theory and empirical evidence. Nowhere is the inadequacy of current methods more visible than in classroom assessment. Reliability arguments would also permit additional methodologies for evidencing reliability in classrooms. It would liberalize methodology…

  7. Collection-limited theory interprets the extraordinary response of single semiconductor organic solar cells

    PubMed Central

    Ray, Biswajit; Baradwaj, Aditya G.; Khan, Mohammad Ryyan; Boudouris, Bryan W.; Alam, Muhammad Ashraful

    2015-01-01

    The bulk heterojunction (BHJ) organic photovoltaic (OPV) architecture has dominated the literature due to its ability to be implemented in devices with relatively high efficiency values. However, a simpler device architecture based on a single organic semiconductor (SS-OPV) offers several advantages: it obviates the need to control the highly system-dependent nanoscale BHJ morphology, and therefore, would allow the use of broader range of organic semiconductors. Unfortunately, the photocurrent in standard SS-OPV devices is typically very low, which generally is attributed to inefficient charge separation of the photogenerated excitons. Here we show that the short-circuit current density from SS-OPV devices can be enhanced significantly (∼100-fold) through the use of inverted device configurations, relative to a standard OPV device architecture. This result suggests that charge generation may not be the performance bottleneck in OPV device operation. Instead, poor charge collection, caused by defect-induced electric field screening, is most likely the primary performance bottleneck in regular-geometry SS-OPV cells. We justify this hypothesis by: (i) detailed numerical simulations, (ii) electrical characterization experiments of functional SS-OPV devices using multiple polymers as active layer materials, and (iii) impedance spectroscopy measurements. Furthermore, we show that the collection-limited photocurrent theory consistently interprets typical characteristics of regular SS-OPV devices. These insights should encourage the design and OPV implementation of high-purity, high-mobility polymers, and other soft materials that have shown promise in organic field-effect transistor applications, but have not performed well in BHJ OPV devices, wherein they adopt less-than-ideal nanostructures when blended with electron-accepting materials. PMID:26290582

  8. Collection-limited theory interprets the extraordinary response of single semiconductor organic solar cells

    DOE PAGES

    Ray, Biswajit; Baradwaj, Aditya G.; Khan, Mohammad Ryyan; ...

    2015-08-19

    The bulk heterojunction (BHJ) organic photovoltaic (OPV) architecture has dominated the literature due to its ability to be implemented in devices with relatively high efficiency values. However, a simpler device architecture based on a single organic semiconductor (SS-OPV) offers several advantages: it obviates the need to control the highly system-dependent nanoscale BHJ morphology, and therefore, would allow the use of broader range of organic semiconductors. Unfortunately, the photocurrent in standard SS-OPV devices is typically very low, which generally is attributed to inefficient charge separation of the photogenerated excitons. In this paper, we show that the short-circuit current density from SS-OPVmore » devices can be enhanced significantly (~100-fold) through the use of inverted device configurations, relative to a standard OPV device architecture. This result suggests that charge generation may not be the performance bottleneck in OPV device operation. Instead, poor charge collection, caused by defect-induced electric field screening, is most likely the primary performance bottleneck in regular-geometry SS-OPV cells. We justify this hypothesis by: (i) detailed numerical simulations, (ii) electrical characterization experiments of functional SS-OPV devices using multiple polymers as active layer materials, and (iii) impedance spectroscopy measurements. Furthermore, we show that the collection-limited photocurrent theory consistently interprets typical characteristics of regular SS-OPV devices. Finally, these insights should encourage the design and OPV implementation of high-purity, high-mobility polymers, and other soft materials that have shown promise in organic field-effect transistor applications, but have not performed well in BHJ OPV devices, wherein they adopt less-than-ideal nanostructures when blended with electron-accepting materials.« less

  9. Collection-limited theory interprets the extraordinary response of single semiconductor organic solar cells.

    PubMed

    Ray, Biswajit; Baradwaj, Aditya G; Khan, Mohammad Ryyan; Boudouris, Bryan W; Alam, Muhammad Ashraful

    2015-09-08

    The bulk heterojunction (BHJ) organic photovoltaic (OPV) architecture has dominated the literature due to its ability to be implemented in devices with relatively high efficiency values. However, a simpler device architecture based on a single organic semiconductor (SS-OPV) offers several advantages: it obviates the need to control the highly system-dependent nanoscale BHJ morphology, and therefore, would allow the use of broader range of organic semiconductors. Unfortunately, the photocurrent in standard SS-OPV devices is typically very low, which generally is attributed to inefficient charge separation of the photogenerated excitons. Here we show that the short-circuit current density from SS-OPV devices can be enhanced significantly (∼100-fold) through the use of inverted device configurations, relative to a standard OPV device architecture. This result suggests that charge generation may not be the performance bottleneck in OPV device operation. Instead, poor charge collection, caused by defect-induced electric field screening, is most likely the primary performance bottleneck in regular-geometry SS-OPV cells. We justify this hypothesis by: (i) detailed numerical simulations, (ii) electrical characterization experiments of functional SS-OPV devices using multiple polymers as active layer materials, and (iii) impedance spectroscopy measurements. Furthermore, we show that the collection-limited photocurrent theory consistently interprets typical characteristics of regular SS-OPV devices. These insights should encourage the design and OPV implementation of high-purity, high-mobility polymers, and other soft materials that have shown promise in organic field-effect transistor applications, but have not performed well in BHJ OPV devices, wherein they adopt less-than-ideal nanostructures when blended with electron-accepting materials.

  10. Implications of complex adaptive systems theory for the design of research on health care organizations

    PubMed Central

    McDaniel, Reuben R.; Lanham, Holly Jordan; Anderson, Ruth A.

    2013-01-01

    Background Because health care organizations (HCOs) are complex adaptive systems (CASs), phenomena of interest often are dynamic and unfold in unpredictable ways, and unfolding events are often unique. Researchers of HCOs may recognize that the subject of their research is dynamic; however, their research designs may not take this into account. Researchers may also know that unfolding events are often unique, but their design may not have the capacity to obtain information from meager evidence. Purpose These two concerns led us to examine two ideas from organizational theory: (a) the ideas of K. E. Weick (1993) on organizational design as a verb and (b) the ideas of J. G. March, L. S. Sproull, and M. Tamuz (1991) on learning from samples of one or fewer. In this article, we applied these ideas to develop an enriched perspective of research design for studying CASs. Methodology/Approach We conducted a theoretical analysis of organizations as CASs, identifying relevant characteristics for research designs. We then explored two ideas from organizational theory and discussed the implications for research designs. Findings Weick's idea of “design as a verb” helps in understanding dynamic and process-oriented research design. The idea of “learning from samples of one or fewer” of March, Sproull, and Tamuz provides strategies for research design that enables learning from meager evidence. When studying HCOs, research designs are likely to be more effective when they (a) anticipate change, (b) include tension, (c) capitalize on serendipity, and (d) use an “act-then-look” mind set. Implications for practice are discussed. Practice Implications Practitioners who understand HCOs as CASs will be cautious in accepting findings from studies that treat HCOs mechanistically. They will consider the characteristics of CAS when evaluating the evidence base for practice. Practitioners can use the strategies proposed in this article to stimulate discussion with researchers

  11. Nuclear weapons decision-making; an application of organization theory to the mini-nuke case

    SciTech Connect

    Kangas, J.L.

    1985-01-01

    This dissertation addresses the problem of constructing and developing normative theory responsive to the need for improving the quality of decision-making in the nuclear weapons policy-making. Against the background of a critical evaluation of various paradigms in the literature (systems analysis and opposed-systems designed, the bureaucratic politics model, and the cybernetic theory of decision) an attempt is made to design an alternative analytic framework based on the writings of numerous organization theorists such as Herbert Simon and Kenneth Arrow. The framework is applied to the case of mini-nukes, i.e., proposals in the mid-1970s to develop and deploy tens of thousands of very low-yield (sub-kiloton), miniaturized fission weapons in NATO. Heuristic case study identifies the type of study undertaken in the dissertation in contrast to the more familiar paradigmatic studies identified, for example, with the Harvard Weapons Project. Application of the analytic framework developed in the dissertation of the mini-nuke case resulted in an empirical understanding of why decision making concerning tactical nuclear weapons has been such a complex task and why force modernization issues in particular have been so controversial and lacking in policy resolution.

  12. Coding theory based models for protein translation initiation in prokaryotic organisms.

    PubMed

    May, Elebeoba E; Vouk, Mladen A; Bitzer, Donald L; Rosnick, David I

    2004-01-01

    Our research explores the feasibility of using communication theory, error control (EC) coding theory specifically, for quantitatively modeling the protein translation initiation mechanism. The messenger RNA (mRNA) of Escherichia coli K-12 is modeled as a noisy (errored), encoded signal and the ribosome as a minimum Hamming distance decoder, where the 16S ribosomal RNA (rRNA) serves as a template for generating a set of valid codewords (the codebook). We tested the E. coli based coding models on 5' untranslated leader sequences of prokaryotic organisms of varying taxonomical relation to E. coli including: Salmonella typhimurium LT2, Bacillus subtilis, and Staphylococcus aureus Mu50. The model identified regions on the 5' untranslated leader where the minimum Hamming distance values of translated mRNA sub-sequences and non-translated genomic sequences differ the most. These regions correspond to the Shine-Dalgarno domain and the non-random domain. Applying the EC coding-based models to B. subtilis, and S. aureus Mu50 yielded results similar to those for E. coli K-12. Contrary to our expectations, the behavior of S. typhimurium LT2, the more taxonomically related to E. coli, resembled that of the non-translated sequence group.

  13. Coding theory based models for protein translation initiation in prokaryotic organisms.

    SciTech Connect

    May, Elebeoba Eni; Bitzer, Donald L. (North Carolina State University, Raleigh, NC); Rosnick, David I. (North Carolina State University, Raleigh, NC); Vouk, Mladen A.

    2003-03-01

    Our research explores the feasibility of using communication theory, error control (EC) coding theory specifically, for quantitatively modeling the protein translation initiation mechanism. The messenger RNA (mRNA) of Escherichia coli K-12 is modeled as a noisy (errored), encoded signal and the ribosome as a minimum Hamming distance decoder, where the 16S ribosomal RNA (rRNA) serves as a template for generating a set of valid codewords (the codebook). We tested the E. coli based coding models on 5' untranslated leader sequences of prokaryotic organisms of varying taxonomical relation to E. coli including: Salmonella typhimurium LT2, Bacillus subtilis, and Staphylococcus aureus Mu50. The model identified regions on the 5' untranslated leader where the minimum Hamming distance values of translated mRNA sub-sequences and non-translated genomic sequences differ the most. These regions correspond to the Shine-Dalgarno domain and the non-random domain. Applying the EC coding-based models to B. subtilis, and S. aureus Mu50 yielded results similar to those for E. coli K-12. Contrary to our expectations, the behavior of S. typhimurium LT2, the more taxonomically related to E. coli, resembled that of the non-translated sequence group.

  14. Functional Organization of the Action Observation Network in Autism: A Graph Theory Approach

    PubMed Central

    Alaerts, Kaat; Geerlings, Franca; Herremans, Lynn; Swinnen, Stephan P.; Verhoeven, Judith; Sunaert, Stefan; Wenderoth, Nicole

    2015-01-01

    Background The ability to recognize, understand and interpret other’s actions and emotions has been linked to the mirror system or action-observation-network (AON). Although variations in these abilities are prevalent in the neuro-typical population, persons diagnosed with autism spectrum disorders (ASD) have deficits in the social domain and exhibit alterations in this neural network. Method Here, we examined functional network properties of the AON using graph theory measures and region-to-region functional connectivity analyses of resting-state fMRI-data from adolescents and young adults with ASD and typical controls (TC). Results Overall, our graph theory analyses provided convergent evidence that the network integrity of the AON is altered in ASD, and that reductions in network efficiency relate to reductions in overall network density (i.e., decreased overall connection strength). Compared to TC, individuals with ASD showed significant reductions in network efficiency and increased shortest path lengths and centrality. Importantly, when adjusting for overall differences in network density between ASD and TC groups, participants with ASD continued to display reductions in network integrity, suggesting that also network-level organizational properties of the AON are altered in ASD. Conclusion While differences in empirical connectivity contributed to reductions in network integrity, graph theoretical analyses provided indications that also changes in the high-level network organization reduced integrity of the AON. PMID:26317222

  15. Functional Organization of the Action Observation Network in Autism: A Graph Theory Approach.

    PubMed

    Alaerts, Kaat; Geerlings, Franca; Herremans, Lynn; Swinnen, Stephan P; Verhoeven, Judith; Sunaert, Stefan; Wenderoth, Nicole

    2015-01-01

    The ability to recognize, understand and interpret other's actions and emotions has been linked to the mirror system or action-observation-network (AON). Although variations in these abilities are prevalent in the neuro-typical population, persons diagnosed with autism spectrum disorders (ASD) have deficits in the social domain and exhibit alterations in this neural network. Here, we examined functional network properties of the AON using graph theory measures and region-to-region functional connectivity analyses of resting-state fMRI-data from adolescents and young adults with ASD and typical controls (TC). Overall, our graph theory analyses provided convergent evidence that the network integrity of the AON is altered in ASD, and that reductions in network efficiency relate to reductions in overall network density (i.e., decreased overall connection strength). Compared to TC, individuals with ASD showed significant reductions in network efficiency and increased shortest path lengths and centrality. Importantly, when adjusting for overall differences in network density between ASD and TC groups, participants with ASD continued to display reductions in network integrity, suggesting that also network-level organizational properties of the AON are altered in ASD. While differences in empirical connectivity contributed to reductions in network integrity, graph theoretical analyses provided indications that also changes in the high-level network organization reduced integrity of the AON.

  16. The search for reliable aqueous solubility (Sw) and octanol-water partition coefficient (Kow) data for hydrophobic organic compounds; DDT and DDE as a case study

    USGS Publications Warehouse

    Pontolillo, James; Eganhouse, R.P.

    2001-01-01

    The accurate determination of an organic contaminant?s physico-chemical properties is essential for predicting its environmental impact and fate. Approximately 700 publications (1944?2001) were reviewed and all known aqueous solubilities (Sw) and octanol-water partition coefficients (Kow) for the organochlorine pesticide, DDT, and its persistent metabolite, DDE were compiled and examined. Two problems are evident with the available database: 1) egregious errors in reporting data and references, and 2) poor data quality and/or inadequate documentation of procedures. The published literature (particularly the collative literature such as compilation articles and handbooks) is characterized by a preponderance of unnecessary data duplication. Numerous data and citation errors are also present in the literature. The percentage of original Sw and Kow data in compilations has decreased with time, and in the most recent publications (1994?97) it composes only 6?26 percent of the reported data. The variability of original DDT/DDE Sw and Kow data spans 2?4 orders of magnitude, and there is little indication that the uncertainty in these properties has declined over the last 5 decades. A criteria-based evaluation of DDT/DDE Sw and Kow data sources shows that 95?100 percent of the database literature is of poor or unevaluatable quality. The accuracy and reliability of the vast majority of the data are unknown due to inadequate documentation of the methods of determination used by the authors. [For example, estimates of precision have been reported for only 20 percent of experimental Sw data and 10 percent of experimental Kow data.] Computational methods for estimating these parameters have been increasingly substituted for direct or indirect experimental determination despite the fact that the data used for model development and validation may be of unknown reliability. Because of the prevalence of errors, the lack of methodological documentation, and unsatisfactory data

  17. Analyzing Determinants of Hospitals' Accountable Care Organizations Participation: A Resource Dependency Theory Perspective.

    PubMed

    Yeager, Valerie A; Zhang, Yongkang; Diana, Mark L

    2015-12-01

    Accountable care organizations (ACOs) are rapidly being implemented across the United States, but little is known about what environmental and organizational factors are associated with hospital participation in ACOs. Using resource dependency theory, this study examines external environmental characteristics and organizational characteristics that relate to hospital participation in Medicare ACOs. Results indicate hospitals operating in more munificent environments (as measured by income per capita: β = 0.00002, p < .05) and more competitive environments (as measured by Health Maintenance Organization penetration: β = 1.86, p < .01) are more likely to participate in ACOs. Organizational characteristics including hospital ownership, health care system membership, electronic health records implementation, hospital type, percentage of Medicaid inpatient discharge, and number of nursing home beds per 1,000 population over 65 are also related to ACO participation. Should the anticipated benefits of ACOs be realized, findings from this study can guide strategies to encourage hospitals that have not gotten involved in ACOs. © The Author(s) 2015.

  18. Prediction of Charge Mobility in Amorphous Organic Materials through the Application of Hopping Theory.

    PubMed

    Lee, Choongkeun; Waterland, Robert; Sohlberg, Karl

    2011-08-09

    The application of hopping theory to predict charge (hole) mobility in amorphous organic molecular materials is studied in detail. Application is made to amorphous cells of N,N'-diphenyl-N,N'-bis-(3-methylphenylene)-1,1'-diphenyl-4,4'-diamine (TPD), 1,1-bis-(4,4'-diethylaminophenyl)-4,4-diphenyl-1,3,butadinene (DEPB), N4,N4'-di(biphenyl-3-yl)-N4,N4'-diphenylbiphenyl-4,4'-diamine (mBPD), N1,N4-di(naphthalen-1-yl)-N1,N4-diphenylbenzene-1,4-diamine (NNP), and N,N'-bis[9,9-dimethyl-2-fluorenyl]-N,N'-diphenyl-9,9-dimethylfluorene-2,7-diamine (pFFA). Detailed analysis of the computation of each of the parameters in the equations for hopping rate is presented, including studies of their convergence with respect to various numerical approximations. Based on these convergence studies, the most robust methodology is then applied to investigate the dependence of mobility on such parameters as the monomer reorganization energy, the monomer-monomer coupling, and the material density. The results give insight into what will be required to improve the accuracy of predictions of mobility in amorphous organic materials, and what factors should be controlled to develop materials with higher (or lower) charge (hole) mobility.

  19. Simple, stable and reliable modeling of gas properties of organic working fluids in aerodynamic designs of turbomachinery for ORC and VCC

    NASA Astrophysics Data System (ADS)

    Kawakubo, T.

    2016-05-01

    A simple, stable and reliable modeling of the real gas nature of the working fluid is required for the aerodesigns of the turbine in the Organic Rankine Cycle and of the compressor in the Vapor Compression Cycle. Although many modern Computational Fluid Dynamics tools are capable of incorporating real gas models, simulations with such a gas model tend to be more time-consuming than those with a perfect gas model and even can be unstable due to the simulation near the saturation boundary. Thus a perfect gas approximation is still an attractive option to stably and swiftly conduct a design simulation. In this paper, an effective method of the CFD simulation with a perfect gas approximation is discussed. A method of representing the performance of the centrifugal compressor or the radial-inflow turbine by means of each set of non-dimensional performance parameters and translating the fictitious perfect gas result to the actual real gas performance is presented.

  20. Discovery of fairy circles in Australia supports self-organization theory

    PubMed Central

    Getzin, Stephan; Yizhaq, Hezi; Bell, Bronwyn; Erickson, Todd E.; Postle, Anthony C.; Katra, Itzhak; Tzuk, Omer; Zelnik, Yuval R.; Wiegand, Kerstin; Wiegand, Thorsten; Meron, Ehud

    2016-01-01

    Vegetation gap patterns in arid grasslands, such as the “fairy circles” of Namibia, are one of nature’s greatest mysteries and subject to a lively debate on their origin. They are characterized by small-scale hexagonal ordering of circular bare-soil gaps that persists uniformly in the landscape scale to form a homogeneous distribution. Pattern-formation theory predicts that such highly ordered gap patterns should be found also in other water-limited systems across the globe, even if the mechanisms of their formation are different. Here we report that so far unknown fairy circles with the same spatial structure exist 10,000 km away from Namibia in the remote outback of Australia. Combining fieldwork, remote sensing, spatial pattern analysis, and process-based mathematical modeling, we demonstrate that these patterns emerge by self-organization, with no correlation with termite activity; the driving mechanism is a positive biomass–water feedback associated with water runoff and biomass-dependent infiltration rates. The remarkable match between the patterns of Australian and Namibian fairy circles and model results indicate that both patterns emerge from a nonuniform stationary instability, supporting a central universality principle of pattern-formation theory. Applied to the context of dryland vegetation, this principle predicts that different systems that go through the same instability type will show similar vegetation patterns even if the feedback mechanisms and resulting soil–water distributions are different, as we indeed found by comparing the Australian and the Namibian fairy-circle ecosystems. These results suggest that biomass–water feedbacks and resultant vegetation gap patterns are likely more common in remote drylands than is currently known. PMID:26976567

  1. A regulatory theory of cortical organization and its applications to robotics

    NASA Astrophysics Data System (ADS)

    Thangavelautham, Jekanthan

    2009-11-01

    Fundamental aspects of biologically-inspired regulatory mechanisms are considered in a robotics context, using artificial neural-network control systems. Regulatory mechanisms are used to control expression of genes, adaptation of form and behavior in organisms. Traditional neural network control architectures assume networks of neurons are fixed and are interconnected by wires. However, these architectures tend to be specified by a designer and are faced with several limitations that reduce scalability and tractability for tasks with larger search spaces. Traditional methods used to overcome these limitations with fixed network topologies are to provide more supervision by a designer. More supervision as shown does not guarantee improvement during training particularly when making incorrect assumptions for little known task domains. Biological organisms often do not require such external intervention (more supervision) and have self-organized through adaptation. Artificial neural tissues (ANT) addresses limitations with current neural-network architectures by modeling both wired interactions between neurons and wireless interactions through use of chemical diffusion fields. An evolutionary (Darwinian) selection process is used to 'breed' ANT controllers for a task at hand and the framework facilitates emergence of creative solutions since only a system goal function and a generic set of basis behaviours need be defined. Regulatory mechanisms are formed dynamically within ANT through superpositioning of chemical diffusion fields from multiple sources and are used to select neuronal groups. Regulation drives competition and cooperation among neuronal groups and results in areas of specialization forming within the tissue. These regulatory mechanisms are also shown to increase tractability without requiring more supervision using a new statistical theory developed to predict performance characteristics of fixed network topologies. Simulations also confirm the

  2. hfAIM: A reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated Atg8-interacting motifs in various organisms.

    PubMed

    Xie, Qingjun; Tzfadia, Oren; Levy, Matan; Weithorn, Efrat; Peled-Zehavi, Hadas; Van Parys, Thomas; Van de Peer, Yves; Galili, Gad

    2016-05-03

    Most of the proteins that are specifically turned over by selective autophagy are recognized by the presence of short Atg8 interacting motifs (AIMs) that facilitate their association with the autophagy apparatus. Such AIMs can be identified by bioinformatics methods based on their defined degenerate consensus F/W/Y-X-X-L/I/V sequences in which X represents any amino acid. Achieving reliability and/or fidelity of the prediction of such AIMs on a genome-wide scale represents a major challenge. Here, we present a bioinformatics approach, high fidelity AIM (hfAIM), which uses additional sequence requirements-the presence of acidic amino acids and the absence of positively charged amino acids in certain positions-to reliably identify AIMs in proteins. We demonstrate that the use of the hfAIM method allows for in silico high fidelity prediction of AIMs in AIM-containing proteins (ACPs) on a genome-wide scale in various organisms. Furthermore, by using hfAIM to identify putative AIMs in the Arabidopsis proteome, we illustrate a potential contribution of selective autophagy to various biological processes. More specifically, we identified 9 peroxisomal PEX proteins that contain hfAIM motifs, among which AtPEX1, AtPEX6 and AtPEX10 possess evolutionary-conserved AIMs. Bimolecular fluorescence complementation (BiFC) results verified that AtPEX6 and AtPEX10 indeed interact with Atg8 in planta. In addition, we show that mutations occurring within or nearby hfAIMs in PEX1, PEX6 and PEX10 caused defects in the growth and development of various organisms. Taken together, the above results suggest that the hfAIM tool can be used to effectively perform genome-wide in silico screens of proteins that are potentially regulated by selective autophagy. The hfAIM system is a web tool that can be accessed at link: http://bioinformatics.psb.ugent.be/hfAIM/.

  3. 18 CFR 39.5 - Reliability Standards.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... competition. (d) An approved Reliability Standard or modification to a Reliability Standard shall take effect... will not defer to the Electric Reliability Organization or a Regional Entity with respect to the...

  4. Modeling Atmospheric Secondary Organic Aerosol Dynamics through Chemistry, Emissions, and Partition Theory

    NASA Astrophysics Data System (ADS)

    Chang, Wayne Li-wen

    2011-12-01

    The detrimental impact on both human health and global climate of atmospheric particular matter (PM) is now well-established. Among the various classifications of PM, a significant portion is comprised of secondary organic aerosol (SOA). Despite its importance, there are still much uncertainty regarding the formation and evolution of SOA in the atmosphere, beginning with the oxidation of organic gases that leads to semi-volatile and low volatility products. The need to further improve the current knowledge SOA is made apparent by the observed large discrepancy between model predictions and field measurements of SOA. Proposed explanations behind the orders of magnitude underprediction of ambient SOA levels by state-of-the-art airshed models include: missing particle-forming oxidized organic products, unidentified SOA precursor emissions, and issues related to the fundamentals of current SOA partition theory, all of which are considered in this study to develop corresponding improvements to the latest airshed models. The model used in this study is the UCI-CIT airshed model, and the improvement scenario tests are set in the urban region of South Coast Air Basin of California. Recent chamber results have shown that the original implementation of alkane-derived SOA provided an underestimate for what was likely to be occurring in urban atmospheres. Thus, the original chemical mechanism is revised to include higher generation products of medium- and long-chain alkanes that can contribute to SOA in this study. Primary organic aerosol (POA) has been identified to be able to evaporate with dilution; therefore, test cases are developed that treat fractions of POA as semi-volatile, a source of SOA, rather than nonvolatile. While current atmospheric models assume that SOA are liquids into which semi-VOCs undergo equilibrium partitioning and grow the particles, recent laboratory and field experiments have shown otherwise. Hence, a new kinetics-driven partition theory is

  5. An Exploratory Study on University Students' Perceptions of Posthumous Organ Donation Base on the Theory of Reasoned Action.

    PubMed

    Wong, Shui Hung; Chow, Amy Yin Man

    2017-08-01

    In view of the general support for organ donation but low registration rate in Hong Kong, the present research attempted to understand the attitude-behavior inconsistency by identifying the underlying beliefs for organ donation through employing the theory of reasoned action. A qualitative approach using semi-structured focus groups was adopted and 19 students from three universities in Hong Kong participated; 10 constructs were identified: attitude, subjective norm, helping, continuation, contribution, body intact, distrust to the medical system, indifference to organ donation, negative affect, and family burden. Findings suggested that their attitudes toward organ donation were of both the cognitive and affective nature; subjective norm of family, friends, and people they respect were identified as influential to students' views on organ donation. The study provided insight in promoting organ donation, that the cognitive concerns about keeping the body intact, and the negative affects introduced should also be addressed.

  6. Species Detection and Identification in Sexual Organisms Using Population Genetic Theory and DNA Sequences

    PubMed Central

    Birky, C. William

    2013-01-01

    Phylogenetic trees of DNA sequences of a group of specimens may include clades of two kinds: those produced by stochastic processes (random genetic drift) within a species, and clades that represent different species. The ratio of the mean pairwise sequence difference between a pair of clades (K) to the mean pairwise sequence difference within a clade (θ) can be used to determine whether the clades are samples from different species (K/θ≥4) or the same species (K/θ<4) with probability ≥0.95. Previously I applied this criterion to delimit species of asexual organisms. Here I use data from the literature to show how it can also be applied to delimit sexual species using four groups of sexual organisms as examples: ravens, spotted leopards, sea butterflies, and liverworts. Mitochondrial or chloroplast genes are used because these segregate earlier during speciation than most nuclear genes and hence detect earlier stages of speciation. In several cases the K/θ ratio was greater than 4, confirming the original authors' intuition that the clades were sufficiently different to be assigned to different species. But the K/θ ratio split each of two liverwort species into two evolutionary species, and showed that support for the distinction between the common and Chihuahuan raven species is weak. I also discuss some possible sources of error in using the K/θ ratio; the most significant one would be cases where males migrate between different populations but females do not, making the use of maternally inherited organelle genes problematic. The K/θ ratio must be used with some caution, like all other methods for species delimitation. Nevertheless, it is a simple theory-based quantitative method for using DNA sequences to make rigorous decisions about species delimitation in sexual as well as asexual eukaryotes. PMID:23308113

  7. The organic surface of 5145 Pholus: Constraints set by scattering theory

    NASA Technical Reports Server (NTRS)

    Wilson, Peter D.; Sagan, Carl; Thompson, W. Reid

    1994-01-01

    No known body in the Solar System has a spectrum redder than that of object 5145 Pholus. We use Hapke scattering theory and optical constants measured in this laboratory to examine the ability of mixtures of a number of organic solids and ices to reproduce the observed spectrum and phase variation. The primary materials considered are poly-HCN, kerogen, Murchison organic extract, Titan tholin, ice tholin, and water ice. In a computer grid search of over 10 million models, we find an intraparticle mixture of 15% Titan tholin, 10% poly-HCN, and 75% water ice with 10-micrometers particles to provide an excellent fit. Replacing water ice with ammonia ice improves the fits significantly while using a pure hydrocarbon tholin, Tholin alpha, instead of Titan tholin makes only modest improvements. All acceptable fits require Titan tholin or some comparable material to provide the steep slope in the visible, and poly-HCN or some comparable material to provide strong absorption in the near-infrared. A pure Titan tholin surface with 16-micrometers particles, as well as all acceptable Pholus models, fit the present spectrophotometric data for the transplutonian object 1992 QB(sub 1). The feasibility of gas-phase chemistry to generate material like Titan tholin on such small objects is examined. An irradiated transient atmosphere arising from sublimating ices may generate at most a few centimeters of tholin over the lifetime of the Solar System, but this is insignificant compared to the expected lag deposit of primordial contaminants left behind by the sublimating ice. Irradiation of subsurface N2/CH4 or NH3/CH4 ice by cosmic rays may generate approximately 20 cm of tholin in the upper 10 m of regolith in the same time scale but the identity of this tholin to its gas-phase equivalent has not been demonstrated.

  8. Dispersion corrected hartree-fock and density functional theory for organic crystal structure prediction.

    PubMed

    Brandenburg, Jan Gerit; Grimme, Stefan

    2014-01-01

    We present and evaluate dispersion corrected Hartree-Fock (HF) and Density Functional Theory (DFT) based quantum chemical methods for organic crystal structure prediction. The necessity of correcting for missing long-range electron correlation, also known as van der Waals (vdW) interaction, is pointed out and some methodological issues such as inclusion of three-body dispersion terms are discussed. One of the most efficient and widely used methods is the semi-classical dispersion correction D3. Its applicability for the calculation of sublimation energies is investigated for the benchmark set X23 consisting of 23 small organic crystals. For PBE-D3 the mean absolute deviation (MAD) is below the estimated experimental uncertainty of 1.3 kcal/mol. For two larger π-systems, the equilibrium crystal geometry is investigated and very good agreement with experimental data is found. Since these calculations are carried out with huge plane-wave basis sets they are rather time consuming and routinely applicable only to systems with less than about 200 atoms in the unit cell. Aiming at crystal structure prediction, which involves screening of many structures, a pre-sorting with faster methods is mandatory. Small, atom-centered basis sets can speed up the computation significantly but they suffer greatly from basis set errors. We present the recently developed geometrical counterpoise correction gCP. It is a fast semi-empirical method which corrects for most of the inter- and intramolecular basis set superposition error. For HF calculations with nearly minimal basis sets, we additionally correct for short-range basis incompleteness. We combine all three terms in the HF-3c denoted scheme which performs very well for the X23 sublimation energies with an MAD of only 1.5 kcal/mol, which is close to the huge basis set DFT-D3 result.

  9. The organic surface of 5145 Pholus: Constraints set by scattering theory

    NASA Technical Reports Server (NTRS)

    Wilson, Peter D.; Sagan, Carl; Thompson, W. Reid

    1994-01-01

    No known body in the Solar System has a spectrum redder than that of object 5145 Pholus. We use Hapke scattering theory and optical constants measured in this laboratory to examine the ability of mixtures of a number of organic solids and ices to reproduce the observed spectrum and phase variation. The primary materials considered are poly-HCN, kerogen, Murchison organic extract, Titan tholin, ice tholin, and water ice. In a computer grid search of over 10 million models, we find an intraparticle mixture of 15% Titan tholin, 10% poly-HCN, and 75% water ice with 10-micrometers particles to provide an excellent fit. Replacing water ice with ammonia ice improves the fits significantly while using a pure hydrocarbon tholin, Tholin alpha, instead of Titan tholin makes only modest improvements. All acceptable fits require Titan tholin or some comparable material to provide the steep slope in the visible, and poly-HCN or some comparable material to provide strong absorption in the near-infrared. A pure Titan tholin surface with 16-micrometers particles, as well as all acceptable Pholus models, fit the present spectrophotometric data for the transplutonian object 1992 QB(sub 1). The feasibility of gas-phase chemistry to generate material like Titan tholin on such small objects is examined. An irradiated transient atmosphere arising from sublimating ices may generate at most a few centimeters of tholin over the lifetime of the Solar System, but this is insignificant compared to the expected lag deposit of primordial contaminants left behind by the sublimating ice. Irradiation of subsurface N2/CH4 or NH3/CH4 ice by cosmic rays may generate approximately 20 cm of tholin in the upper 10 m of regolith in the same time scale but the identity of this tholin to its gas-phase equivalent has not been demonstrated.

  10. From Structural Dilemmas to Institutional Imperatives: A Descriptive Theory of the School as an Institution and of School Organizations

    ERIC Educational Resources Information Center

    Berg, Gunnar

    2007-01-01

    This study outlines a descriptive theory that seeks to grasp the complexity of the school as a state and societal institution as well as single schools as organizations. A significant characteristic of this complexity is the ambiguity of the missions and goals--the outer boundaries--of the school-institution. The more institutional ambiguity that…

  11. Body without Organs: Notes on Deleuze & Guattari, Critical Race Theory and the Socius of Anti-Racism

    ERIC Educational Resources Information Center

    Ibrahim, Awad

    2015-01-01

    My aim in this article is to epistemologically read Deleuze and Guattari (D & G) against critical race theory (CRT) and simultaneously delineate how D & G's notion of "body without organs" can benefit from CRT. At first glance, especially for language instructors and researchers, these two epistemological frameworks not only…

  12. The Process by Which Black Male College Students Become Leaders of Predominantly White Organizations in Higher Education: A Grounded Theory

    ERIC Educational Resources Information Center

    Moschella, Eric J.

    2013-01-01

    This study sought to understand the process by which Black undergraduate men on predominately White college campuses become leaders of predominately White organizations. Using the theoretical frameworks of Black and White racial identity development (Helms, 1990), Critical Race Theory (Delgado & Stefancic, 2001), and Wijeyesinghe's (2001)…

  13. Body without Organs: Notes on Deleuze & Guattari, Critical Race Theory and the Socius of Anti-Racism

    ERIC Educational Resources Information Center

    Ibrahim, Awad

    2015-01-01

    My aim in this article is to epistemologically read Deleuze and Guattari (D & G) against critical race theory (CRT) and simultaneously delineate how D & G's notion of "body without organs" can benefit from CRT. At first glance, especially for language instructors and researchers, these two epistemological frameworks not only…

  14. Network organization is globally atypical in autism: A graph theory study of intrinsic functional connectivity.

    PubMed

    Keown, Christopher L; Datko, Michael C; Chen, Colleen P; Maximo, José Omar; Jahedi, Afrooz; Müller, Ralph-Axel

    2017-01-01

    Despite abundant evidence of brain network anomalies in autism spectrum disorder (ASD), findings have varied from broad functional underconnectivity to broad overconnectivity. Rather than pursuing overly simplifying general hypotheses ('under' vs. 'over'), we tested the hypothesis of atypical network distribution in ASD (i.e., participation of unusual loci in distributed functional networks). We used a selective high-quality data subset from the ABIDE datashare (including 111 ASD and 174 typically developing [TD] participants) and several graph theory metrics. Resting state functional MRI data were preprocessed and analyzed for detection of low-frequency intrinsic signal correlations. Groups were tightly matched for available demographics and head motion. As hypothesized, the Rand Index (reflecting how similar network organization was to a normative set of networks) was significantly lower in ASD than TD participants. This was accounted for by globally reduced cohesion and density, but increased dispersion of networks. While differences in hub architecture did not survive correction, rich club connectivity (among the hubs) was increased in the ASD group. Our findings support the model of reduced network integration (connectivity with networks) and differentiation (or segregation; based on connectivity outside network boundaries) in ASD. While the findings applied at the global level, they were not equally robust across all networks and in one case (greater cohesion within ventral attention network in ASD) even reversed.

  15. The effect of the labile organic fraction in food waste and the substrate/inoculum ratio on anaerobic digestion for a reliable methane yield.

    PubMed

    Kawai, Minako; Nagao, Norio; Tajima, Nobuaki; Niwa, Chiaki; Matsuyama, Tatsushi; Toda, Tatsuki

    2014-04-01

    Influence of the labile organic fraction (LOF) on anaerobic digestion of food waste was investigated in different S/I ratio of 0.33, 0.5, 1.0, 2.0 and 4.0g-VSsubstrate/g-VSinoculum. Two types of substrate, standard food waste (Substrate 1) and standard food waste with the supernatant (containing LOF) removed (Substrate 2) were used. Highest methane yield of 435ml-CH4g-VS(-1) in Substrate 1 was observed in the lowest S/I ratio, while the methane yield of the other S/I ratios were 38-73% lower than the highest yield due to acidification. The methane yields in Substrate 2 were relatively stable in all S/I conditions, although the maximum methane yield was low compared with Substrate 1. These results showed that LOF in food waste causes acidification, but also contributes to high methane yields, suggesting that low S/I ratio (<0.33) is required to obtain a reliable methane yield from food waste compared to other organic substrates. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Human hair growth ex vivo is correlated with in vivo hair growth: selective categorization of hair follicles for more reliable hair follicle organ culture.

    PubMed

    Kwon, Oh Sang; Oh, Jun Kyu; Kim, Mi Hyang; Park, So Hyun; Pyo, Hyun Keol; Kim, Kyu Han; Cho, Kwang Hyun; Eun, Hee Chul

    2006-02-01

    Of the numerous assays used to assess hair growth, hair follicle organ culture model is one of the most popular and powerful in vitro systems. Changes in hair growth are commonly employed as a measurement of follicular activity. Hair cycle stage of mouse vibrissa follicles in vivo is known to determine subsequent hair growth and follicle behavior in vitro and it is recommended that follicles be taken at precisely the same cyclic stage. This study was performed to evaluate whether categorization of human hair follicles by the growth in vivo could be used to select follicles of the defined anagen stage for more consistent culture. Occipital scalp samples were obtained from three subjects, 2 weeks later after hair bleaching. Hair growth and follicle length of isolated anagen VI follicles were measured under a videomicroscope. Follicles were categorized into four groups according to hair growth and some were cultured ex vivo for 6 days. Follicles showed considerable variations with respect to hair growth and follicle length; however, these two variables were relatively well correlated. Hair growth in culture was closely related with hair growth rate in vivo. Moreover, minoxidil uniquely demonstrated a significant increase of hair growth in categorized hair follicles assumed at a similar early anagen VI stage of hair cycle. Selection of follicles at a defined stage based on hair-growth rate would permit a more reliable outcome in human hair follicle organ culture.

  17. A Theory of Complex Adaptive Inquiring Organizations: Application to Continuous Assurance of Corporate Financial Information

    ERIC Educational Resources Information Center

    Kuhn, John R., Jr.

    2009-01-01

    Drawing upon the theories of complexity and complex adaptive systems and the Singerian Inquiring System from C. West Churchman's seminal work "The Design of Inquiring Systems" the dissertation herein develops a systems design theory for continuous auditing systems. The dissertation consists of discussion of the two foundational theories,…

  18. A Theory of Complex Adaptive Inquiring Organizations: Application to Continuous Assurance of Corporate Financial Information

    ERIC Educational Resources Information Center

    Kuhn, John R., Jr.

    2009-01-01

    Drawing upon the theories of complexity and complex adaptive systems and the Singerian Inquiring System from C. West Churchman's seminal work "The Design of Inquiring Systems" the dissertation herein develops a systems design theory for continuous auditing systems. The dissertation consists of discussion of the two foundational theories,…

  19. The relationship between personality organization as assessed by theory-driven profiles of the Dutch Short Form of the MMPI and self-reported features of personality organization.

    PubMed

    Eurelings-Bontekoe, Elisabeth H M; Luyten, Patrick; Remijsen, Mila; Koelen, Jurrijn

    2010-11-01

    In this study, we investigated the relationships between features of personality organization (PO) as assessed by theory driven profiles of the Dutch Short Form of the MMPI (DSFM; Luteijn & Kok, 1985) and 2 self-report measures of personality pathology, that is, the Dutch Inventory of Personality Organization (Berghuis, Kamphuis, Boedijn, & Verheul, 2009) and the Dutch Schizotypy Personality Questionnaire-Revised (Vollema & Hoijtink, 2000), in a sample of 190 outpatient psychiatric patients. Results showed that the single scales of all 3 measures segregated into 2 theoretically expected and meaningful dimensions, that is, a dimension assessing severity of personality pathology and an introversion/extraversion dimension. Theory-driven combinations of single DSFM subscales as a measure of level of PO distinguished characteristics of patients at various levels of PO in theoretically predicted ways. Results also suggest that structural personality pathology may not be fully captured by self-report measures.

  20. Intentions of becoming a living organ donor among Hispanics: a theory-based approach exploring differences between living and nonliving organ donation.

    PubMed

    Siegel, Jason T; Alvaro, Eusebio M; Lac, Andrew; Crano, William D; Dominick, Alexander

    2008-01-01

    This research examines perceptions concerning living (n = 1,253) and nonliving (n = 1,259) organ donation among Hispanic adults, a group considerably less likely than the general population to become donors. Measures are derived from the Theory of Planned Behavior (Ajzen, 1991) and Vested Interest Theory (Crano, 1983, 1997). A substantial percentage of respondents reported positive attitudes and high personal stake concerning organ donation. Mean differences in norms, attitudes, intentions, and assumed immediacy of payoff were found between living and nonliving donor groups, suggesting that these two donation formats are dissimilar and should be examined independently. Accordingly, separate hierarchical multiple regression models were estimated for living and nonliving donation. Analyses supported both theoretical frameworks: Constructs associated with Planned Behavior and Vested Interest independently contributed to donor intentions. The implications of these results, and our recommendations for future health campaigns, are presented in light of these theoretical models.

  1. Person Reliability

    ERIC Educational Resources Information Center

    Lumsden, James

    1977-01-01

    Person changes can be of three kinds: developmental trends, swells, and tremors. Person unreliability in the tremor sense (momentary fluctuations) can be estimated from person characteristic curves. Average person reliability for groups can be compared from item characteristic curves. (Author)

  2. An Examination of Test-Retest, Alternate Form Reliability, and Generalizability Theory Study of the easyCBM Word and Passage Reading Fluency Assessments: Grade 3. Technical Report #1218

    ERIC Educational Resources Information Center

    Park, Bitnara Jasmine; Anderson, Daniel; Alonzo, Julie; Lai, Cheng-Fei; Tindal, Gerald

    2012-01-01

    This technical report is one in a series of five describing the reliability (test/retest and alternate form) and G-Theory/D-Study research on the easyCBM reading measures, grades 1-5. Data were gathered in the spring of 2011 from a convenience sample of students nested within classrooms at a medium-sized school district in the Pacific Northwest.…

  3. The neural crest and neural crest cells: discovery and significance for theories of embryonic organization.

    PubMed

    Hall, Brian K

    2008-12-01

    The neural crest has long fascinated developmental biologists,and,increasingly over the past decades,evolutionary and evolutionary developmental biologists.The neural crest is the name given to the fold of ectoderm at the junction between neural and epidermal ectoderm in neurula-stage vertebrate embryos.In this sense,the neural crest is a morphological term akin to head fold or limb bud.This region of the dorsal neural tube consists of neural crest cells,a special population(s)of cell,that give rise to an astonishing number of cell types and to an equally astonishing number of tissues and organs.Neural crest cell contributions may be direct - providing cells - or indirect - providing a necessary, often inductive, environment in which other cells develop.The enormous range of cell types produced provides an important source of evidence of the neural crest as a germ layer, bringing the number of germ layers to four - ectoderm,endoderm,mesoderm,and neural crest. In this paper I provide a brief overview of the major phases of investigation into the neural crest and the major players involved,discuss how the origin of the neural crest relates to the origin of the nervous system in vertebrate embryos,discuss the impact on the germ-layer theory of the discovery of the neural crest and of secondary neurulation,and present evidence of the neural crest as the fourth germ layer.A companion paper (Hall, Evol. Biol.2008) deals with the evolutionary origins of the neural crest and neural crest cells.

  4. Elastic, not plastic species: Frozen plasticity theory and the origin of adaptive evolution in sexually reproducing organisms

    PubMed Central

    2010-01-01

    Background Darwin's evolutionary theory could easily explain the evolution of adaptive traits (organs and behavioral patterns) in asexual but not in sexual organisms. Two models, the selfish gene theory and frozen plasticity theory were suggested to explain evolution of adaptive traits in sexual organisms in past 30 years. Results The frozen plasticity theory suggests that sexual species can evolve new adaptations only when their members are genetically uniform, i.e. only after a portion of the population of the original species had split off, balanced on the edge of extinction for several generations, and then undergone rapid expansion. After a short period of time, estimated on the basis of paleontological data to correspond to 1-2% of the duration of the species, polymorphism accumulates in the gene pool due to frequency-dependent selection; and thus, in each generation, new mutations occur in the presence of different alleles and therefore change their selection coefficients from generation to generation. The species ceases to behave in an evolutionarily plastic manner and becomes evolutionarily elastic on a microevolutionary time-scale and evolutionarily frozen on a macroevolutionary time-scale. It then exists in this state until such changes accumulate in the environment that the species becomes extinct. Conclusion Frozen plasticity theory, which includes the Darwinian model of evolution as a special case - the evolution of species in a plastic state, not only offers plenty of new predictions to be tested, but also provides explanations for a much broader spectrum of known biological phenomena than classic evolutionary theories. Reviewers This article was reviewed by Rob Knight, Fyodor Kondrashov and Massimo Di Giulio (nominated by David H. Ardell). PMID:20067646

  5. Elastic, not plastic species: frozen plasticity theory and the origin of adaptive evolution in sexually reproducing organisms.

    PubMed

    Flegr, Jaroslav

    2010-01-13

    Darwin's evolutionary theory could easily explain the evolution of adaptive traits (organs and behavioral patterns) in asexual but not in sexual organisms. Two models, the selfish gene theory and frozen plasticity theory were suggested to explain evolution of adaptive traits in sexual organisms in past 30 years. The frozen plasticity theory suggests that sexual species can evolve new adaptations only when their members are genetically uniform, i.e. only after a portion of the population of the original species had split off, balanced on the edge of extinction for several generations, and then undergone rapid expansion. After a short period of time, estimated on the basis of paleontological data to correspond to 1-2% of the duration of the species, polymorphism accumulates in the gene pool due to frequency-dependent selection; and thus, in each generation, new mutations occur in the presence of different alleles and therefore change their selection coefficients from generation to generation. The species ceases to behave in an evolutionarily plastic manner and becomes evolutionarily elastic on a microevolutionary time-scale and evolutionarily frozen on a macroevolutionary time-scale. It then exists in this state until such changes accumulate in the environment that the species becomes extinct. Frozen plasticity theory, which includes the Darwinian model of evolution as a special case--the evolution of species in a plastic state, not only offers plenty of new predictions to be tested, but also provides explanations for a much broader spectrum of known biological phenomena than classic evolutionary theories. This article was reviewed by Rob Knight, Fyodor Kondrashov and Massimo Di Giulio (nominated by David H. Ardell).

  6. hfAIM: A reliable bioinformatics approach for in silico genome-wide identification of autophagy-associated Atg8-interacting motifs in various organisms

    PubMed Central

    Xie, Qingjun; Tzfadia, Oren; Levy, Matan; Weithorn, Efrat; Peled-Zehavi, Hadas; Van Parys, Thomas; Van de Peer, Yves; Galili, Gad

    2016-01-01

    ABSTRACT Most of the proteins that are specifically turned over by selective autophagy are recognized by the presence of short Atg8 interacting motifs (AIMs) that facilitate their association with the autophagy apparatus. Such AIMs can be identified by bioinformatics methods based on their defined degenerate consensus F/W/Y-X-X-L/I/V sequences in which X represents any amino acid. Achieving reliability and/or fidelity of the prediction of such AIMs on a genome-wide scale represents a major challenge. Here, we present a bioinformatics approach, high fidelity AIM (hfAIM), which uses additional sequence requirements—the presence of acidic amino acids and the absence of positively charged amino acids in certain positions—to reliably identify AIMs in proteins. We demonstrate that the use of the hfAIM method allows for in silico high fidelity prediction of AIMs in AIM-containing proteins (ACPs) on a genome-wide scale in various organisms. Furthermore, by using hfAIM to identify putative AIMs in the Arabidopsis proteome, we illustrate a potential contribution of selective autophagy to various biological processes. More specifically, we identified 9 peroxisomal PEX proteins that contain hfAIM motifs, among which AtPEX1, AtPEX6 and AtPEX10 possess evolutionary-conserved AIMs. Bimolecular fluorescence complementation (BiFC) results verified that AtPEX6 and AtPEX10 indeed interact with Atg8 in planta. In addition, we show that mutations occurring within or nearby hfAIMs in PEX1, PEX6 and PEX10 caused defects in the growth and development of various organisms. Taken together, the above results suggest that the hfAIM tool can be used to effectively perform genome-wide in silico screens of proteins that are potentially regulated by selective autophagy. The hfAIM system is a web tool that can be accessed at link: http://bioinformatics.psb.ugent.be/hfAIM/. PMID:27071037

  7. Autotrophs' challenge to Dynamic Energy Budget theory: Comment on ;Physics of metabolic organization; by Marko Jusup et al.

    NASA Astrophysics Data System (ADS)

    Geček, Sunčana

    2017-03-01

    Jusup and colleagues in the recent review on physics of metabolic organization [1] discuss in detail motivational considerations and common assumptions of Dynamic Energy Budget (DEB) theory, supply readers with a practical guide to DEB-based modeling, demonstrate the construction and dynamics of the standard DEB model, and illustrate several applications. The authors make a step forward from the existing literature by seamlessly bridging over the dichotomy between (i) thermodynamic foundations of the theory (which are often more accessible and understandable to physicists and mathematicians), and (ii) the resulting bioenergetic models (mostly used by biologists in real-world applications).

  8. Assessment of Student Performance in a PSI College Physics Course Using Ausubel's Learning Theory as a Theoretical Framework for Content Organization.

    ERIC Educational Resources Information Center

    Moriera, M. A.

    1979-01-01

    David Ausubel's learning theory was used as a framework for the content organization of an experimental Personalized System of Instruction (PSI) course in physics. Evaluation suggests that the combination of PSI as a method of instruction and Ausubel's theory for organization might result in better learning outcomes. (Author/JMD)

  9. Assessment of Student Performance in a PSI College Physics Course Using Ausubel's Learning Theory as a Theoretical Framework for Content Organization.

    ERIC Educational Resources Information Center

    Moriera, M. A.

    1979-01-01

    David Ausubel's learning theory was used as a framework for the content organization of an experimental Personalized System of Instruction (PSI) course in physics. Evaluation suggests that the combination of PSI as a method of instruction and Ausubel's theory for organization might result in better learning outcomes. (Author/JMD)

  10. Overcoming the Problem of Embedding Change in Educational Organizations: A Perspective from Normalization Process Theory

    ERIC Educational Resources Information Center

    Wood, Phil

    2017-01-01

    In this article, I begin by outlining some of the barriers which constrain sustainable organizational change in schools and universities. I then go on to introduce a theory which has already started to help explain complex change and innovation processes in health and care contexts, Normalization Process Theory. Finally, I consider what this…

  11. Overcoming the Problem of Embedding Change in Educational Organizations: A Perspective from Normalization Process Theory

    ERIC Educational Resources Information Center

    Wood, Phil

    2017-01-01

    In this article, I begin by outlining some of the barriers which constrain sustainable organizational change in schools and universities. I then go on to introduce a theory which has already started to help explain complex change and innovation processes in health and care contexts, Normalization Process Theory. Finally, I consider what this…

  12. Communication as a predictor of willingness to donate one's organs: an addition to the Theory of Reasoned Action.

    PubMed

    Jeffres, Leo W; Carroll, Jeanine A; Rubenking, Bridget E; Amschlinger, Joe

    2008-12-01

    Fishbein and Ajzen's theory of reasoned action has been used by many researchers, particularly in regard to health communication, to predict behavioral intentions and behavior. According to that theory, one's intention is the best predictor that one will engage in a behavior, and attitudes and social norms predict behavioral intentions. Other researchers have added different variables to the postulates of attitudes and social norms that Fishbein and Ajzen maintain are the best predictors of behavioral intention. Here we draw on data from a 2006 telephone survey (N = 420) gauging the awareness of an organ donation campaign in Northeast Ohio to examine the impact of communication on people's intentions. The current study supports the hypothesis that those who communicate with others are more likely to express a greater willingness to become an organ donor, but it expands the range of communication contexts. With demographics and attitudes toward organ donation controlled for, this study shows that communication with others about organ donation increases the willingness of individuals to have favorable attitudes about being an organ donor.

  13. A theory for classification of health care organizations in the new economy.

    PubMed

    Vimarlund, Vivian; Sjöberg, Cecilia; Timpka, Toomas

    2003-10-01

    Most of the available studies into information technology (IT) have been limited to investigating specific issues, such as how IT can support decision makers distributing the information throughout health care organization, or how technology impacts organizational performance. In this study, for use in the planning of information system development projects, a theoretical model for the classification of health care organizations is proposed. We try to reflect the development in the contemporary digital economy by theoretically classifying health care organizations into three types, namely traditional, developing, and flexible. We describe traditional health care organizations as organizations with a centralized system for management and control. In developing health care organizations, IT is spread over the horizontal dimension and is used for coordinating the different parties throughout the organization. Finally, flexible health care organizations are those which work actively with the design of new health care organizational structure while they are designing the information system.

  14. 78 FR 77574 - Protection System Maintenance Reliability Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Information), Office of Electric Reliability, Federal Energy Regulatory Commission, 888 First Street NE... shedding equipment affecting the bulk electric system. While the proposed Reliability Standard also gives... Electric Reliability Organization (ERO) to develop mandatory and enforceable Reliability Standards, subject...

  15. Reliability physics

    NASA Technical Reports Server (NTRS)

    Cuddihy, E. F.; Ross, R. G., Jr.

    1984-01-01

    Speakers whose topics relate to the reliability physics of solar arrays are listed and their topics briefly reviewed. Nine reports are reviewed ranging in subjects from studies of photothermal degradation in encapsulants and polymerizable ultraviolet stabilizers to interface bonding stability to electrochemical degradation of photovoltaic modules.

  16. Regulating agents, functional interactions, and stimulus-reaction-schemes: the concept of "organism" in the organic system theories of Stahl, Bordeu, and Barthez.

    PubMed

    Cheung, Tobias

    2008-12-01

    In this essay, I sketch a problem-based framework within which I locate the concept of "organism" in the system theories of Georg Ernst Stahl, Théophile Bordeu, and Paul-Joseph Barthez. Around 1700, Stahl coins the word "organism" for a certain concept of order. For him, the concept explains the form of order of living bodies that is categorically different from the order of other (dead) bodies or composites. At the end of the century, the "organism" as a specific form of order becomes a major topos in many discourses. I will not so much focus on experiments and objects as on basic problems that contribute to the general framework of the concept of organism as a key concept of the vitalist movement between 1700 and 1800. For this purpose, I will investigate the combination of three explanatory tools. These tools refer to regulating agents, functional interactions, and stimulus-reactions-schemes within individual organic systems of forces. They are related to various themes--especially to energy, sensibility, and sympathy. I will retrace some aspects of these relations.

  17. A Monte Carlo Simulation Investigating the Validity and Reliability of Ability Estimation in Item Response Theory with Speeded Computer Adaptive Tests

    ERIC Educational Resources Information Center

    Schmitt, T. A.; Sass, D. A.; Sullivan, J. R.; Walker, C. M.

    2010-01-01

    Imposed time limits on computer adaptive tests (CATs) can result in examinees having difficulty completing all items, thus compromising the validity and reliability of ability estimates. In this study, the effects of speededness were explored in a simulated CAT environment by varying examinee response patterns to end-of-test items. Expectedly,…

  18. Multifractality to Photonic Crystal & Self-Organization to Metamaterials through Anderson Localizations & Group/Gauge Theory

    NASA Astrophysics Data System (ADS)

    Hidajatullah-Maksoed, Widastra

    2015-04-01

    Arthur Cayley at least investigate by creating the theory of permutation group[F:∖∖Group_theory.htm] where in cell elements addressing of the lattice Qmf used a Cayley tree, the self-afine object Qmf is described by the combination of the finite groups of rotation & inversion and the infinite groups of translation & dilation[G Corso & LS Lacena: ``Multifractal lattice and group theory'', Physica A: Statistical Mechanics &Its Applications, 2005, v 357, issue I, h 64-70; http://www.sciencedirect.com/science/articel/pii/S0378437105005005 ] hence multifractal can be related to group theory. Many grateful Thanks to HE. Mr. Drs. P. SWANTORO & HE. Mr. Ir. SARWONO KUSUMAATMADJA.

  19. Challenges for dynamic energy budget theory. Comment on ;Physics of metabolic organization; by Marko Jusup et al.

    NASA Astrophysics Data System (ADS)

    Nisbet, Roger M.

    2017-03-01

    Jusup et al. [1] provide a comprehensive review of Dynamic Energy Budget (DEB) theory - a theory of metabolic organization that has its roots in a model by S.A.L.M Kooijman [2] and has evolved over three decades into a remarkable general theory whose use appears to be growing exponentially. The definitive text on DEB theory [3] is a challenging (though exceptionally rewarding) read, and previous reviews (e.g. [4,5]) have provided focused summaries of some of its main themes, targeted at specific groups of readers. The strong case for a further review is well captured in the abstract: ;Hitherto, the foundations were more accessible to physicists or mathematicians, and the applications to biologists, causing a dichotomy in what always should have been a single body of work.; In response to this need, Jusup et al. provide a review that combines a lucid, rigorous exposition of the core components of DEB theory with a diverse collection of DEB applications. They also highlight some recent advances, notably the rapidly growing on-line database of DEB model parameters (451 species on 15 August 2016 according to [1], now, just a few months later, over 500 species).

  20. From Theory to Practice: Using New Science Concepts to Create Learning Organizations

    ERIC Educational Resources Information Center

    Shelton, Charlotte D.; Darling, John R.

    2003-01-01

    For the past ten years the management literature has increasingly discussed the concept of learning organizations. Yet, more that a decade later, few organizations have figured out how to create the structures and processes necessary to assure continuous learning. This article purports that this problem can be attributed to the mental models of…

  1. Understanding the Environmental Elements in Religious Student Organizations through Sharon Parks' Mentoring Community Theory

    ERIC Educational Resources Information Center

    Gill, David Christopher

    2011-01-01

    Students are coming to colleges and universities for spiritual fulfillment and have turned to religious student organizations (i.e. Campus Crusade for Christ, Newman Centers, Muslim Student Association, Hillel, etc.) to attain guidance and support. To better understand the spiritual environment religious student organizations have in place, many…

  2. The Learning Organization: Theory and Practice. Myths and Realities No. 12.

    ERIC Educational Resources Information Center

    Wonacott, Michael E.

    The learning organization (LO) can be described as an organizational culture in which individual development is a priority, outmoded and erroneous ways of thinking are actively identified and corrected, and all members clearly understand and support the purpose and vision of the organization. The LO has proved difficult to define. These five…

  3. Toward a Theory of Variation in the Organization of the Word Reading System

    ERIC Educational Resources Information Center

    Rueckl, Jay G.

    2016-01-01

    The strategy underlying most computational models of word reading is to specify the organization of the reading system--its architecture and the processes and representations it employs--and to demonstrate that this organization would give rise to the behavior observed in word reading tasks. This approach fails to adequately address the variation…

  4. Understanding the Environmental Elements in Religious Student Organizations through Sharon Parks' Mentoring Community Theory

    ERIC Educational Resources Information Center

    Gill, David Christopher

    2011-01-01

    Students are coming to colleges and universities for spiritual fulfillment and have turned to religious student organizations (i.e. Campus Crusade for Christ, Newman Centers, Muslim Student Association, Hillel, etc.) to attain guidance and support. To better understand the spiritual environment religious student organizations have in place, many…

  5. Toward a Theory of Variation in the Organization of the Word Reading System

    ERIC Educational Resources Information Center

    Rueckl, Jay G.

    2016-01-01

    The strategy underlying most computational models of word reading is to specify the organization of the reading system--its architecture and the processes and representations it employs--and to demonstrate that this organization would give rise to the behavior observed in word reading tasks. This approach fails to adequately address the variation…

  6. Potential Applications of Matrix Organization Theory for the New Jersey Department of Education. Position Paper.

    ERIC Educational Resources Information Center

    Hanson, J. Robert

    Matrix organization focuses on the shift from cost center or process input planning to product output or results planning. Matrix organization puts the personnel and the resources where they are needed to get the job done. This management efficiency is brought about by dividing all organizational activities into two areas: (1) input or maintenance…

  7. 75 FR 71625 - System Restoration Reliability Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... effect on the human environment.\\33\\ The actions proposed here fall within the categorical exclusion in... Commission by the North American Electric Reliability Corporation, the Electric Reliability Organization (ERO... CONTACT: David O'Connor (Technical Information), Office of Electric Reliability, Division of Reliability...

  8. 76 FR 16277 - System Restoration Reliability Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... Resource'' submitted to the Commission for approval by the North American Electric Reliability Corporation (NERC), the Electric Reliability Organization certified by the Commission. The approved Reliability...) 502-6498. David O'Connor (Technical Information), Office of Electric Reliability, Division of...

  9. Power laws and self-organized criticality in theory and nature

    NASA Astrophysics Data System (ADS)

    Marković, Dimitrije; Gros, Claudius

    2014-03-01

    Power laws and distributions with heavy tails are common features of many complex systems. Examples are the distribution of earthquake magnitudes, solar flare intensities and the sizes of neuronal avalanches. Previously, researchers surmised that a single general concept may act as an underlying generative mechanism, with the theory of self organized criticality being a weighty contender. The power-law scaling observed in the primary statistical analysis is an important, but by far not the only feature characterizing experimental data. The scaling function, the distribution of energy fluctuations, the distribution of inter-event waiting times, and other higher order spatial and temporal correlations, have seen increased consideration over the last years. Leading to realization that basic models, like the original sandpile model, are often insufficient to adequately describe the complexity of real-world systems with power-law distribution. Consequently, a substantial amount of effort has gone into developing new and extended models and, hitherto, three classes of models have emerged. The first line of models is based on a separation between the time scales of an external drive and an internal dissipation, and includes the original sandpile model and its extensions, like the dissipative earthquake model. Within this approach the steady state is close to criticality in terms of an absorbing phase transition. The second line of models is based on external drives and internal dynamics competing on similar time scales and includes the coherent noise model, which has a non-critical steady state characterized by heavy-tailed distributions. The third line of models proposes a non-critical self-organizing state, being guided by an optimization principle, such as the concept of highly optimized tolerance. We present a comparative overview regarding distinct modeling approaches together with a discussion of their potential relevance as underlying generative models for real

  10. New Evidence for the Theory of Chromosome Organization by Repetitive Elements (CORE)

    PubMed Central

    Tang, Shao-Jun

    2017-01-01

    Repetitive DNA elements were proposed to coordinate chromatin folding and interaction in chromosomes by their intrinsic homology-based clustering ability. A recent analysis of the data sets from chromosome-conformation-capture experiments confirms the spatial clustering of DNA repeats of the same family in the nuclear space, and thus provides strong new support for the CORE theory. PMID:28230735

  11. New Evidence for the Theory of Chromosome Organization by Repetitive Elements (CORE).

    PubMed

    Tang, Shao-Jun

    2017-02-20

    Repetitive DNA elements were proposed to coordinate chromatin folding and interaction in chromosomes by their intrinsic homology-based clustering ability. A recent analysis of the data sets from chromosome-conformation-capture experiments confirms the spatial clustering of DNA repeats of the same family in the nuclear space, and thus provides strong new support for the CORE theory.

  12. Network reliability

    NASA Technical Reports Server (NTRS)

    Johnson, Marjory J.

    1985-01-01

    Network control (or network management) functions are essential for efficient and reliable operation of a network. Some control functions are currently included as part of the Open System Interconnection model. For local area networks, it is widely recognized that there is a need for additional control functions, including fault isolation functions, monitoring functions, and configuration functions. These functions can be implemented in either a central or distributed manner. The Fiber Distributed Data Interface Medium Access Control and Station Management protocols provide an example of distributed implementation. Relative information is presented here in outline form.

  13. Reliability Prediction

    NASA Technical Reports Server (NTRS)

    1993-01-01

    RELAV, a NASA-developed computer program, enables Systems Control Technology, Inc. (SCT) to predict performance of aircraft subsystems. RELAV provides a system level evaluation of a technology. Systems, the mechanism of a landing gear for example, are first described as a set of components performing a specific function. RELAV analyzes the total system and the individual subsystem probabilities to predict success probability, and reliability. This information is then translated into operational support and maintenance requirements. SCT provides research and development services in support of government contracts.

  14. Knowledge sharing within organizations: linking art, theory, scenarios and professional experience

    NASA Technical Reports Server (NTRS)

    Bailey, T.; Burton, Y. C.

    2000-01-01

    In this discussion, T. Bailey will be addressing the multiple paradigms within organizations using imagery. Dr. Burton will discuss the relationship between these paradigms and social exchanges that lead to knowledge sharing.

  15. Knowledge sharing within organizations: linking art, theory, scenarios and professional experience

    NASA Technical Reports Server (NTRS)

    Bailey, T.; Burton, Y. C.

    2000-01-01

    In this discussion, T. Bailey will be addressing the multiple paradigms within organizations using imagery. Dr. Burton will discuss the relationship between these paradigms and social exchanges that lead to knowledge sharing.

  16. Organic-Chemical Clues to the Theory of Impacts as a Cause of Mass Extinctions

    NASA Astrophysics Data System (ADS)

    Sack, N. J.

    1988-11-01

    The reasons for the mass extinctions, which occur from time to time in Earth's history-as, e.g., the dinosaur extinction at the Cretaceous/Tertiary boundary 65 myr ago - are still not satisfactorily cleared up. A possible reason might be the impact of one or several comets of several kilometers in diameter. In this paper the astrophysical background of this hypothesis and organic-chemical processes during an impact will be discussed. Quantitative estimations are given, which show that the amount of organic substances brought to the Earth may be of the same order of magnitude as the normal biological production of organic material. Investigations are proposed to examine the organic-chemical composition of profiles of the Cretaceous/Tertiary boundary and other boundaries, at which mass extinction had occurred, in order to find anomalies as consequences of impacts.

  17. Electronic and optical properties of a metal-organic framework with ab initio many-body perturbation theory

    NASA Astrophysics Data System (ADS)

    Berland, Kristian; Lee, Kyuho; Sharifzadeh, Sahar; Neaton, Jeffrey B.

    2015-03-01

    With their unprecedented surface area, and their structural and chemical tunability, metal-organic frameworks (MOFs) are being thoroughly explored for applications related to gas storage. Less studied are their electronic, excited-state, and optical properties. Here we explored such properties of Mg-MOF-74 using a combination of density functional theory (DFT) and many-body perturbation theory (MBPT) within the GW approximation and the Bethe-Salpeter equation (BSE) approach. The near-gap electronic conduction states were found to fall into two distinct categories: molecular-like and 1d-dispersive. Further, using the BSE approach, we predict a strongly anisotropic absorption spectrum, which we link to the nature of its strongly-bound excitons. Our calculations are found to be in good agreement with experimental absorption spectra, validating our theoretical approach. This work is supported by Chalmers Area of Advance: Materials, Vetenskapsradet, DOE, and computational resources provided by NERSC.

  18. Molecular Theory of Detonation Initiation: Insight from First Principles Modeling of the Decomposition Mechanisms of Organic Nitro Energetic Materials

    SciTech Connect

    Tsyshevsky, Roman; Sharia, Onise; Kuklja, Maija

    2016-02-19

    Our review presents a concept, which assumes that thermal decomposition processes play a major role in defining the sensitivity of organic energetic materials to detonation initiation. As a science and engineering community we are still far away from having a comprehensive molecular detonation initiation theory in a widely agreed upon form. However, recent advances in experimental and theoretical methods allow for a constructive and rigorous approach to design and test the theory or at least some of its fundamental building blocks. In this review, we analyzed a set of select experimental and theoretical articles, which were augmented by our own first principles modeling and simulations, to reveal new trends in energetic materials and to refine known existing correlations between their structures, properties, and functions. Lastly, our consideration is intentionally limited to the processes of thermally stimulated chemical reactions at the earliest stage of decomposition of molecules and materials containing defects.

  19. Molecular Theory of Detonation Initiation: Insight from First Principles Modeling of the Decomposition Mechanisms of Organic Nitro Energetic Materials

    DOE PAGES

    Tsyshevsky, Roman; Sharia, Onise; Kuklja, Maija

    2016-02-19

    Our review presents a concept, which assumes that thermal decomposition processes play a major role in defining the sensitivity of organic energetic materials to detonation initiation. As a science and engineering community we are still far away from having a comprehensive molecular detonation initiation theory in a widely agreed upon form. However, recent advances in experimental and theoretical methods allow for a constructive and rigorous approach to design and test the theory or at least some of its fundamental building blocks. In this review, we analyzed a set of select experimental and theoretical articles, which were augmented by our ownmore » first principles modeling and simulations, to reveal new trends in energetic materials and to refine known existing correlations between their structures, properties, and functions. Lastly, our consideration is intentionally limited to the processes of thermally stimulated chemical reactions at the earliest stage of decomposition of molecules and materials containing defects.« less

  20. Molecular Theory of Detonation Initiation: Insight from First Principles Modeling of the Decomposition Mechanisms of Organic Nitro Energetic Materials.

    PubMed

    Tsyshevsky, Roman V; Sharia, Onise; Kuklja, Maija M

    2016-02-19

    This review presents a concept, which assumes that thermal decomposition processes play a major role in defining the sensitivity of organic energetic materials to detonation initiation. As a science and engineering community we are still far away from having a comprehensive molecular detonation initiation theory in a widely agreed upon form. However, recent advances in experimental and theoretical methods allow for a constructive and rigorous approach to design and test the theory or at least some of its fundamental building blocks. In this review, we analyzed a set of select experimental and theoretical articles, which were augmented by our own first principles modeling and simulations, to reveal new trends in energetic materials and to refine known existing correlations between their structures, properties, and functions. Our consideration is intentionally limited to the processes of thermally stimulated chemical reactions at the earliest stage of decomposition of molecules and materials containing defects.

  1. Pioneering topological methods for network-based drug-target prediction by exploiting a brain-network self-organization theory.

    PubMed

    Durán, Claudio; Daminelli, Simone; Thomas, Josephine M; Haupt, V Joachim; Schroeder, Michael; Cannistraci, Carlo Vittorio

    2017-04-26

    The bipartite network representation of the drug-target interactions (DTIs) in a biosystem enhances understanding of the drugs' multifaceted action modes, suggests therapeutic switching for approved drugs and unveils possible side effects. As experimental testing of DTIs is costly and time-consuming, computational predictors are of great aid. Here, for the first time, state-of-the-art DTI supervised predictors custom-made in network biology were compared-using standard and innovative validation frameworks-with unsupervised pure topological-based models designed for general-purpose link prediction in bipartite networks. Surprisingly, our results show that the bipartite topology alone, if adequately exploited by means of the recently proposed local-community-paradigm (LCP) theory-initially detected in brain-network topological self-organization and afterwards generalized to any complex network-is able to suggest highly reliable predictions, with comparable performance with the state-of-the-art-supervised methods that exploit additional (non-topological, for instance biochemical) DTI knowledge. Furthermore, a detailed analysis of the novel predictions revealed that each class of methods prioritizes distinct true interactions; hence, combining methodologies based on diverse principles represents a promising strategy to improve drug-target discovery. To conclude, this study promotes the power of bio-inspired computing, demonstrating that simple unsupervised rules inspired by principles of topological self-organization and adaptiveness arising during learning in living intelligent systems (like the brain) can efficiently equal perform complicated algorithms based on advanced, supervised and knowledge-based engineering. © The Author 2017. Published by Oxford University Press.

  2. Adsorption of AN Organic Molecule on a Corrugated BN/Rh(111) "nanomesh":. Atomistic Simulation Using Density Functional Theory

    NASA Astrophysics Data System (ADS)

    Gomez Diaz, J.; Seitsonen, A. P.; Iannuzzi, M.; Hutter, J.

    2013-05-01

    We perform modelling of the organic hexa-iodo-cyclohexa-m-phenylene (CHP) molecule on the h-BN/Rh(111) nanomesh [M Corso et al., Science 132, 217 (2004)]. The nanomesh structure consists of a Moiré pattern with a periodicity of 3.2 nm. It forms a template on which the molecules preferentially adsorb in the lower-lying "pores". We employ density functional theory in a slab geometry to investigate the adsorption and the abstraction of iodine atoms of the CHP on the nanomesh.

  3. Studies on Mathematical Models of Wet Adhesion and Lifetime Prediction of Organic Coating/Steel by Grey System Theory

    PubMed Central

    Meng, Fandi; Liu, Ying; Liu, Li; Li, Ying; Wang, Fuhui

    2017-01-01

    A rapid degradation of wet adhesion is the key factor controlling coating lifetime, for the organic coatings under marine hydrostatic pressure. The mathematical models of wet adhesion have been studied by Grey System Theory (GST). Grey models (GM) (1, 1) of epoxy varnish (EV) coating/steel and epoxy glass flake (EGF) coating/steel have been established, and a lifetime prediction formula has been proposed on the basis of these models. The precision assessments indicate that the established models are accurate, and the prediction formula is capable of making precise lifetime forecasting of the coatings. PMID:28773073

  4. Intermolecular symmetry-adapted perturbation theory study of large organic complexes

    SciTech Connect

    Heßelmann, Andreas; Korona, Tatiana

    2014-09-07

    Binding energies for the complexes of the S12L database by Grimme [Chem. Eur. J. 18, 9955 (2012)] were calculated using intermolecular symmetry-adapted perturbation theory combined with a density-functional theory description of the interacting molecules. The individual interaction energy decompositions revealed no particular change in the stabilisation pattern as compared to smaller dimer systems at equilibrium structures. This demonstrates that, to some extent, the qualitative description of the interaction of small dimer systems may be extrapolated to larger systems, a method that is widely used in force-fields in which the total interaction energy is decomposed into atom-atom contributions. A comparison of the binding energies with accurate experimental reference values from Grimme, the latter including thermodynamic corrections from semiempirical calculations, has shown a fairly good agreement to within the error range of the reference binding energies.

  5. Intermolecular symmetry-adapted perturbation theory study of large organic complexes.

    PubMed

    Heßelmann, Andreas; Korona, Tatiana

    2014-09-07

    Binding energies for the complexes of the S12L database by Grimme [Chem. Eur. J. 18, 9955 (2012)] were calculated using intermolecular symmetry-adapted perturbation theory combined with a density-functional theory description of the interacting molecules. The individual interaction energy decompositions revealed no particular change in the stabilisation pattern as compared to smaller dimer systems at equilibrium structures. This demonstrates that, to some extent, the qualitative description of the interaction of small dimer systems may be extrapolated to larger systems, a method that is widely used in force-fields in which the total interaction energy is decomposed into atom-atom contributions. A comparison of the binding energies with accurate experimental reference values from Grimme, the latter including thermodynamic corrections from semiempirical calculations, has shown a fairly good agreement to within the error range of the reference binding energies.

  6. Modes of self-organization of diluted bubbly liquids in acoustic fields: One-dimensional theory.

    PubMed

    Gumerov, Nail A; Akhatov, Iskander S

    2017-02-01

    The paper is dedicated to mathematical modeling of self-organization of bubbly liquids in acoustic fields. A continuum model describing the two-way interaction of diluted polydisperse bubbly liquids and acoustic fields in weakly-nonlinear approximation is studied analytically and numerically in the one-dimensional case. It is shown that the regimes of self-organization of monodisperse bubbly liquids can be controlled by only a few dimensionless parameters. Two basic modes, clustering and propagating shock waves of void fraction (acoustically induced transparency), are identified and criteria for their realization in the space of parameters are proposed. A numerical method for solving of one-dimensional self-organization problems is developed. Computational results for mono- and polydisperse systems are discussed.

  7. The Impact of Multiple Master Patient Index Records on the Business Performance of Health Care Organizations: A Qualitative Grounded Theory Study

    ERIC Educational Resources Information Center

    Banton, Cynthia L.

    2014-01-01

    The purpose of this qualitative grounded theory study was to explore and examine the factors that led to the creation of multiple record entries, and present a theory on the impact the problem has on the business performance of health care organizations. A sample of 59 health care professionals across the United States participated in an online…

  8. The Impact of Multiple Master Patient Index Records on the Business Performance of Health Care Organizations: A Qualitative Grounded Theory Study

    ERIC Educational Resources Information Center

    Banton, Cynthia L.

    2014-01-01

    The purpose of this qualitative grounded theory study was to explore and examine the factors that led to the creation of multiple record entries, and present a theory on the impact the problem has on the business performance of health care organizations. A sample of 59 health care professionals across the United States participated in an online…

  9. Immodest Witnesses: Reliability and Writing Assessment

    ERIC Educational Resources Information Center

    Gallagher, Chris W.

    2014-01-01

    This article offers a survey of three reliability theories in writing assessment: positivist, hermeneutic, and rhetorical. Drawing on an interdisciplinary investigation of the notion of "witnessing," this survey emphasizes the kinds of readers and readings each theory of reliability produces and the epistemological grounds on which it…

  10. Immodest Witnesses: Reliability and Writing Assessment

    ERIC Educational Resources Information Center

    Gallagher, Chris W.

    2014-01-01

    This article offers a survey of three reliability theories in writing assessment: positivist, hermeneutic, and rhetorical. Drawing on an interdisciplinary investigation of the notion of "witnessing," this survey emphasizes the kinds of readers and readings each theory of reliability produces and the epistemological grounds on which it…

  11. Theoretical modeling of the linear and nonlinear optical properties of organic crystals within the rigorous local field theory (RLFT)

    SciTech Connect

    Seidler, T.; Stadnicka, K.; Champagne, B.

    2015-03-30

    This contribution summarizes our current findings in the field of calculating and predicting the linear and second-order nonlinear electric susceptibility tensor components of organic crystals. The methodology used for this purpose is based on a combination of the electrostatic interaction scheme developed by Munn and his coworkers (RLFT) with high-level electronic structure calculations. We compare the results of calculations with available experimental data for several examples of molecular crystals. We show the quality of the final results is influenced by i) the chromophore geometry, ii) the method used for molecular properties calculations and iii) the partitioning scheme used. In conclusion we summarize further plans to improve the reliability and predictability of the method.

  12. Using Population Genetic Theory and DNA Sequences for Species Detection and Identification in Asexual Organisms

    PubMed Central

    Birky, C. William; Adams, Joshua; Gemmel, Marlea; Perry, Julia

    2010-01-01

    Background It is widely agreed that species are fundamental units of biology, but there is little agreement on a definition of species or on an operational criterion for delimiting species that is applicable to all organisms. Methodology/Principal Findings We focus on asexual eukaryotes as the simplest case for investigating species and speciation. We describe a model of speciation in asexual organisms based on basic principles of population and evolutionary genetics. The resulting species are independently evolving populations as described by the evolutionary species concept or the general lineage species concept. Based on this model, we describe a procedure for using gene sequences from small samples of individuals to assign them to the same or different species. Using this method of species delimitation, we demonstrate the existence of species as independent evolutionary units in seven groups of invertebrates, fungi, and protists that reproduce asexually most or all of the time. Conclusions/Significance This wide evolutionary sampling establishes the general existence of species and speciation in asexual organisms. The method is well suited for measuring species diversity when phenotypic data are insufficient to distinguish species, or are not available, as in DNA barcoding and environmental sequencing. We argue that it is also widely applicable to sexual organisms. PMID:20498705

  13. Knowledge sharing within organizations: linking art, theory, scenarios and professional experience

    NASA Technical Reports Server (NTRS)

    Burton, Y. C.; Bailey, T.

    2000-01-01

    In this presentation, Burton and Bailey, discuss the challenges and opportunities in developing knowledge sharing systems in organizations. Bailey provides a tool using imagery and collage for identifying and utilizing the diverse values and beliefs of individuals and groups. Burton reveals findings from a business research study that examines how social construction influences knowledge sharing among task oriented groups.

  14. Knowledge sharing within organizations: linking art, theory, scenarios and professional experience

    NASA Technical Reports Server (NTRS)

    Burton, Y. C.; Bailey, T.

    2000-01-01

    In this presentation, Burton and Bailey, discuss the challenges and opportunities in developing knowledge sharing systems in organizations. Bailey provides a tool using imagery and collage for identifying and utilizing the diverse values and beliefs of individuals and groups. Burton reveals findings from a business research study that examines how social construction influences knowledge sharing among task oriented groups.

  15. Understanding the Value of Enterprise Architecture for Organizations: A Grounded Theory Approach

    ERIC Educational Resources Information Center

    Nassiff, Edwin

    2012-01-01

    There is a high rate of information system implementation failures attributed to the lack of alignment between business and information technology strategy. Although enterprise architecture (EA) is a means to correct alignment problems and executives highly rate the importance of EA, it is still not used in most organizations today. Current…

  16. Understanding the Value of Enterprise Architecture for Organizations: A Grounded Theory Approach

    ERIC Educational Resources Information Center

    Nassiff, Edwin

    2012-01-01

    There is a high rate of information system implementation failures attributed to the lack of alignment between business and information technology strategy. Although enterprise architecture (EA) is a means to correct alignment problems and executives highly rate the importance of EA, it is still not used in most organizations today. Current…

  17. Application of variational reduced-density-matrix theory to organic molecules

    NASA Astrophysics Data System (ADS)

    Gidofalvi, Gergely; Mazziotti, David A.

    2005-03-01

    Variational calculation of the two-electron reduced-density matrix (2-RDM), using a new first-order algorithm [D. A. Mazziotti, Phys. Rev. Lett. 93, 213001 (2004)], is applied to medium-sized organic molecules. The calculations reveal systematic trends in the accuracy of the energy with well-known chemical concepts such as hybridization, electronegativity, and atomic size. Furthermore, correlation energies from hydrocarbon chains indicate that the calculation of the 2-RDM subject to two-positivity conditions is size extensive, that is, the energy grows linearly with the number of electrons. Because organic molecules have a well-defined set of functional groups, we employ the trends in energy accuracy of the functional groups to design a correction to the 2-RDM energy for an arbitrary organic molecule. We apply the 2-RDM calculations with the functional-group correction to a large set of organic molecules with different functional groups. Energies with millihartree accuracy are obtained both at equilibrium and nonequilibrium geometries.

  18. Latent Trait Theory Approach to Measuring Person-Organization Fit: Conceptual Rationale and Empirical Evaluation

    ERIC Educational Resources Information Center

    Chernyshenko, Oleksandr S.; Stark, Stephen; Williams, Alex

    2009-01-01

    The purpose of this article is to offer a new approach to measuring person-organization (P-O) fit, referred to here as "Latent fit." Respondents were administered unidimensional forced choice items and were asked to choose the statement in each pair that better reflected the correspondence between their values and those of the…

  19. Control of organ size: development, regeneration, and the role of theory in biology.

    PubMed

    Stevens, Charles F

    2015-02-19

    How organs grow to be the right size for the animal is one of the central mysteries of biology. In a paper in BMC Biology, Khammash et al. propose a mechanism for escaping from the deficiencies of feedback control of growth as a mechanism.

  20. Understanding Program Planning Theory and Practice in a Feminist Community-Based Organization

    ERIC Educational Resources Information Center

    Bracken, Susan J.

    2011-01-01

    The purpose of this article is to discuss feminist-program-planning issues, drawing from a critical ethnographic study of a Latin American feminist community-based organization. The research findings discuss the centrality of feminist identity to understanding and analyzing day-to-day program-planning process issues within a feminist…

  1. To the theory of hybrid organics/semiconductor nanostructures in microcavity

    NASA Astrophysics Data System (ADS)

    Dubovskiy, O. A.; Agranovich, V. M.

    2017-02-01

    We consider the hybrid structure in microcavity where the energy of Frenkel exciton in organic layer is equal to the energy of Wannier - Mott exciton in semiconductor quantum well (QW). The exciton located in QW of semiconductor layer can interact with molecules of organic layer and under influence of this interaction can change the position jumping and exciting one of organic molecules. The exciton located in molecule of organic layer also can change the position jumping to semiconductor QW. The number of such jumps depends on the intensity of interaction. In the paper we consider the influence of direct Coulomb dipole-dipole interaction and indirect interaction through the optical field of microcavity on the kinetics of excitation. It was shown that the dispersion of hybrid states are modified by Coulomb interaction particularly when the distance between layers is enough small. The lowest branch of dispersion curves with deep minimum at nonzero wave vector may be useful in the studies of the condensation of low energy hybrid excitations.

  2. Theory and Practice: Implications for the Implementation of Communication Technology in Organizations.

    ERIC Educational Resources Information Center

    Herndon, Sandra L.

    1997-01-01

    Argues that scientific management principles result in an implementation of technology which fails to take full advantage of organization members and of the technology itself, while in a sociotechnical systems approach, technology is designed and implemented in ways enhancing the potential of both individuals and the technology itself, in…

  3. Reliability analysis in intelligent machines

    NASA Technical Reports Server (NTRS)

    Mcinroy, John E.; Saridis, George N.

    1990-01-01

    Given an explicit task to be executed, an intelligent machine must be able to find the probability of success, or reliability, of alternative control and sensing strategies. By using concepts for information theory and reliability theory, new techniques for finding the reliability corresponding to alternative subsets of control and sensing strategies are proposed such that a desired set of specifications can be satisfied. The analysis is straightforward, provided that a set of Gaussian random state variables is available. An example problem illustrates the technique, and general reliability results are presented for visual servoing with a computed torque-control algorithm. Moreover, the example illustrates the principle of increasing precision with decreasing intelligence at the execution level of an intelligent machine.

  4. Development of a density functional theory in three-dimensional nanoconfined space: H2 storage in metal-organic frameworks.

    PubMed

    Liu, Yu; Liu, Honglai; Hu, Ying; Jiang, Jianwen

    2009-09-10

    A density functional theory (DFT) is developed in three-dimensional nanoconfined space and applied for H(2) storage in metal-organic frameworks. Two different weighting functions based on the weighted density approximation (WDA) are adopted, respectively, for the repulsive and attractive contributions to the excess free energy. The Carnahan-Starling equation and a modified Benedicit-Webb-Rubin equation are used to calculate the excess free energy of uniform fluid. To compare with DFT predictions, grand canonical Monte Carlo simulations are carried out separately. For H(2) adsorption in MOF-5 and ZIF-8, the isotherms predicted from the DFT agree well with simulation and experiment results, and the DFT is found to be superior to the mean-field-approximation (MFA)-based theory. The adsorption energies and isosteric heats predicted are also in accord with simulation results. From the predicted density contours, the DFT shows that the preferential adsorption sites are the corners of metal clusters in MOF-5 and the top of organic linkers in ZIF-8, consistent with simulation and experimental observations.

  5. The self-organizing fractal theory as a universal discovery method: the phenomenon of life.

    PubMed

    Kurakin, Alexei

    2011-03-29

    A universal discovery method potentially applicable to all disciplines studying organizational phenomena has been developed. This method takes advantage of a new form of global symmetry, namely, scale-invariance of self-organizational dynamics of energy/matter at all levels of organizational hierarchy, from elementary particles through cells and organisms to the Universe as a whole. The method is based on an alternative conceptualization of physical reality postulating that the energy/matter comprising the Universe is far from equilibrium, that it exists as a flow, and that it develops via self-organization in accordance with the empirical laws of nonequilibrium thermodynamics. It is postulated that the energy/matter flowing through and comprising the Universe evolves as a multiscale, self-similar structure-process, i.e., as a self-organizing fractal. This means that certain organizational structures and processes are scale-invariant and are reproduced at all levels of the organizational hierarchy. Being a form of symmetry, scale-invariance naturally lends itself to a new discovery method that allows for the deduction of missing information by comparing scale-invariant organizational patterns across different levels of the organizational hierarchy.An application of the new discovery method to life sciences reveals that moving electrons represent a keystone physical force (flux) that powers, animates, informs, and binds all living structures-processes into a planetary-wide, multiscale system of electron flow/circulation, and that all living organisms and their larger-scale organizations emerge to function as electron transport networks that are supported by and, at the same time, support the flow of electrons down the Earth's redox gradient maintained along the core-mantle-crust-ocean-atmosphere axis of the planet. The presented findings lead to a radically new perspective on the nature and origin of life, suggesting that living matter is an organizational state

  6. The self-organizing fractal theory as a universal discovery method: the phenomenon of life

    PubMed Central

    2011-01-01

    A universal discovery method potentially applicable to all disciplines studying organizational phenomena has been developed. This method takes advantage of a new form of global symmetry, namely, scale-invariance of self-organizational dynamics of energy/matter at all levels of organizational hierarchy, from elementary particles through cells and organisms to the Universe as a whole. The method is based on an alternative conceptualization of physical reality postulating that the energy/matter comprising the Universe is far from equilibrium, that it exists as a flow, and that it develops via self-organization in accordance with the empirical laws of nonequilibrium thermodynamics. It is postulated that the energy/matter flowing through and comprising the Universe evolves as a multiscale, self-similar structure-process, i.e., as a self-organizing fractal. This means that certain organizational structures and processes are scale-invariant and are reproduced at all levels of the organizational hierarchy. Being a form of symmetry, scale-invariance naturally lends itself to a new discovery method that allows for the deduction of missing information by comparing scale-invariant organizational patterns across different levels of the organizational hierarchy. An application of the new discovery method to life sciences reveals that moving electrons represent a keystone physical force (flux) that powers, animates, informs, and binds all living structures-processes into a planetary-wide, multiscale system of electron flow/circulation, and that all living organisms and their larger-scale organizations emerge to function as electron transport networks that are supported by and, at the same time, support the flow of electrons down the Earth's redox gradient maintained along the core-mantle-crust-ocean-atmosphere axis of the planet. The presented findings lead to a radically new perspective on the nature and origin of life, suggesting that living matter is an organizational state

  7. Catastrophe theory enables moves to be detected towards and away from self-organization: the example of epileptic seizure onset.

    PubMed

    Cerf, Roger

    2006-06-01

    Macroscopic systems with many interacting subunits, when driven far from equilibrium, exhibit self-organization, for example when a pathological rhythm appears suddenly in an epileptic patient. Sudden changes occurring while conditions vary smoothly have, in cases of interest, underlying mathematics that are the subject of Thom's catastrophe theory. The assumption made herein that the system's state variables, akin to order parameters, reduce in practice to only one single real variable, ensures that the system derives from a potential function, and warrants recourse to the catastrophe theory. The order parameter is, furthermore, interpreted as a measure of the electropathophysiological activity in the brain, increasing monotonously with the degree of neuronal synchronism. With two neuronal influences, excitatory and inhibitory, as control parameters, the catastrophe is the archetypal cusp. Implementation of catastrophe theory leads to equations showing that fluctuations in a system's dynamics may be utilised for signalling steps precursory to oncoming catastrophes. Pre-seizure dynamics in epileptic patients exhibit steps towards and away from catastrophe; the steps away are interpreted in terms of homeostatic feedback, consequent on changing patterns of neuronal activity. A number of characteristics of epileptic seizures of differing types merely follow from the geometry of the cusp equilibrium surface. In particular, types of seizures are distinguished by their angle of final approach to onset in parameter space. The measurable parameters by which approach to catastrophe is characterized, may be of use in investigations of the organism's plasticity in epileptic patients, and in tests of therapeutic means for preventing seizures. There is no need to resort to a model, in the usual sense of the word, and therefore no differential equation needs to be set up.

  8. Ethical models in bioethics: theory and application in organ allocation policies.

    PubMed

    Petrini, C

    2010-12-01

    Policies for allocating organs to people awaiting a transplant constitute a major ethical challenge. First and foremost, they demand balance between the principles of beneficence and justice, but many other ethically relevant principles are also involved: autonomy, responsibility, equity, efficiency, utility, therapeutic outcome, medical urgency, and so forth. Various organ allocation models can be developed based on the hierarchical importance assigned to a given principle over the others, but none of the principles should be completely disregarded. An ethically acceptable organ allocation policy must therefore be in conformity, to a certain extent, with the requirements of all the principles. Many models for organ allocation can be derived. The utilitarian model aims to maximize benefits, which can be of various types on a social or individual level, such as the number of lives saved, prognosis, and so forth. The prioritarian model favours the neediest or those who suffer most. The egalitarian model privileges equity and justice, suggesting that all people should have an equal opportunity (casual allocation) or priority should be given to those who have been waiting longer. The personalist model focuses on each individual patient, attempting to mesh together all the various aspects affecting the person: therapeutic needs (urgency), fairness, clinical outcomes, respect for persons. In the individualistic model the main element is free choice and the system of opting-in is privileged. Contrary to the individualistic model, the communitarian model identities in the community the fundamental elements for the legitimacy of choices: therefore, the system of opting-out is privileged. This article does not aim at suggesting practical solutions. Rather, it furnishes to decision makers an overview on the possible ethical approach to this matter.

  9. Electronic structure of the organic semiconductor copper phthalocyanine: experiment and theory.

    PubMed

    Aristov, V Yu; Molodtsova, O V; Maslyuk, V V; Vyalikh, D V; Zhilin, V M; Ossipyan, Yu A; Bredow, T; Mertig, I; Knupfer, M

    2008-01-21

    The electronic structure of the organic semiconductor copper-phthalocyanine (CuPc) has been determined by a combination of conventional and resonant photoemission, near-edge x-ray absorption, as well as by the first-principles calculations. The experimentally obtained electronic valence band structure of CuPc is in very good agreement with the calculated density of states results, allowing the derivation of detailed site specific information.

  10. Cortical organization: a description and interpretation of anatomical findings based on systems theory

    PubMed Central

    Casanova, Manuel F.

    2012-01-01

    The organization of the cortex can be understood as a complex system comprised of interconnected modules called minicolumns. Comparative anatomical studies suggest that evolution has prompted a scale free world network of connectivity within the white matter while simultaneously increasing the complexity of minicolumnar composition. It is this author’s opinion that this complex system is poised to collapse under the weight of environmental exigencies. Some mental disorders may be the manifestations of this collapse. PMID:22754693

  11. Cortical organization: a description and interpretation of anatomical findings based on systems theory.

    PubMed

    Casanova, Manuel F

    2010-01-01

    The organization of the cortex can be understood as a complex system comprised of interconnected modules called minicolumns. Comparative anatomical studies suggest that evolution has prompted a scale free world network of connectivity within the white matter while simultaneously increasing the complexity of minicolumnar composition. It is this author's opinion that this complex system is poised to collapse under the weight of environmental exigencies. Some mental disorders may be the manifestations of this collapse.

  12. On the purposes of color for living beings: toward a theory of color organization.

    PubMed

    Pinna, Baingio; Reeves, Adam

    2015-01-01

    Phylogenetic and paleontological evidence indicates that in the animal kingdom the ability to perceive colors evolved independently several times over the course of millennia. This implies a high evolutionary neural investment and suggests that color vision provides some fundamental biological benefits. What are these benefits? Why are some animals so colorful? What are the adaptive and perceptual meanings of polychromatism? We suggest that in addition to the discrimination of light and surface chromaticity, sensitivity to color contributes to the whole, the parts and the fragments of perceptual organization. New versions of neon color spreading and the watercolor illusion indicate that the visual purpose of color in humans is threefold: to inter-relate each chromatic component of an object, thus favoring the emergence of the whole; to support a part-whole organization in which components reciprocally enhance each other by amodal completion; and, paradoxically, to reveal fragments and hide the whole-that is, there is a chromatic parceling-out process of separation, division, and fragmentation of the whole. The evolution of these contributions of color to organization needs to be established, but traces of it can be found in Harlequin camouflage by animals and in the coloration of flowers.

  13. Reliable prediction of three-body intermolecular interactions using dispersion-corrected second-order Møller-Plesset perturbation theory

    SciTech Connect

    Huang, Yuanhang; Beran, Gregory J. O.

    2015-07-28

    Three-body and higher intermolecular interactions can play an important role in molecular condensed phases. Recent benchmark calculations found problematic behavior for many widely used density functional approximations in treating 3-body intermolecular interactions. Here, we demonstrate that the combination of second-order Møller-Plesset (MP2) perturbation theory plus short-range damped Axilrod-Teller-Muto (ATM) dispersion accurately describes 3-body interactions with reasonable computational cost. The empirical damping function used in the ATM dispersion term compensates both for the absence of higher-order dispersion contributions beyond the triple-dipole ATM term and non-additive short-range exchange terms which arise in third-order perturbation theory and beyond. Empirical damping enables this simple model to out-perform a non-expanded coupled Kohn-Sham dispersion correction for 3-body intermolecular dispersion. The MP2 plus ATM dispersion model approaches the accuracy of O(N{sup 6}) methods like MP2.5 or even spin-component-scaled coupled cluster models for 3-body intermolecular interactions with only O(N{sup 5}) computational cost.

  14. Reliable prediction of three-body intermolecular interactions using dispersion-corrected second-order Møller-Plesset perturbation theory

    NASA Astrophysics Data System (ADS)

    Huang, Yuanhang; Beran, Gregory J. O.

    2015-07-01

    Three-body and higher intermolecular interactions can play an important role in molecular condensed phases. Recent benchmark calculations found problematic behavior for many widely used density functional approximations in treating 3-body intermolecular interactions. Here, we demonstrate that the combination of second-order Møller-Plesset (MP2) perturbation theory plus short-range damped Axilrod-Teller-Muto (ATM) dispersion accurately describes 3-body interactions with reasonable computational cost. The empirical damping function used in the ATM dispersion term compensates both for the absence of higher-order dispersion contributions beyond the triple-dipole ATM term and non-additive short-range exchange terms which arise in third-order perturbation theory and beyond. Empirical damping enables this simple model to out-perform a non-expanded coupled Kohn-Sham dispersion correction for 3-body intermolecular dispersion. The MP2 plus ATM dispersion model approaches the accuracy of O(N6) methods like MP2.5 or even spin-component-scaled coupled cluster models for 3-body intermolecular interactions with only O(N5) computational cost.

  15. Understanding reaction mechanisms in organic chemistry from catastrophe theory: ozone addition on benzene.

    PubMed

    Ndassa, Ibrahim Mbouombouo; Silvi, Bernard; Volatron, François

    2010-12-16

    The potential energy profiles of the endo and exo additions of ozone on benzene have been theoretically investigated within the framework provided by the electron localization function (ELF). This has been done by carrying out hybrid Hartree-Fock DFT B3LYP calculation followed by a bonding evolution theory (BET) analysis. For both approaches, the reaction is exothermic by ~98 kJ mol(-1). However, the activation energy is calculated to 10 kJ mol(-1) lower in the endo channel than in the exo one; therefore the formation of the endo C(6)H(6)O(3) adduct is kinetically favored. Six structural stability domains are identified along both reaction pathways as well as the bifurcation catastrophes responsible for the changes in the topology of the system. This provides a chemical description of the reaction mechanism in terms of heterolytic synchronous bond formation.

  16. A phenomenological variant of ecological systems theory (PVEST): a self-organization perspective in context.

    PubMed

    Spencer, M B; Dupree, D; Hartmann, T

    1997-01-01

    A framework that emphasizes and integrates individuals' intersubjective experiences with Bronfenbrenner's ecological systems theory (PVEST) is introduced and compared with self-organizational perspectives. Similarities, differences and advantages of each framework are described. In a demonstration of PVEST's utility, a subset of data from the 3rd year of a longitudinal study (14- to 16-year-old middle adolescent African-Americans) is used for examining an achievement variable: negative learning attitude. Explored separately by gender, a regression model that contained risk, stress, and a reactive coping variable for the prediction of negative learning attitudes was investigated. For boys, stress was an independent stressor across steps independent of the other variables entered; social support variable, perceived unpopularity with peers, that was a significant predictor of girls' negative learning attitude. Particularly for boys, the findings suggest critically important roles for teachers and peers in the negative learning attitude of midadolescent economically disadvantaged African-American students.

  17. Attachment at (not to) work: applying attachment theory to explain individual behavior in organizations.

    PubMed

    Richards, David A; Schat, Aaron C H

    2011-01-01

    In this article, we report the results of 2 studies that were conducted to investigate whether adult attachment theory explains employee behavior at work. In the first study, we examined the structure of a measure of adult attachment and its relations with measures of trait affectivity and the Big Five. In the second study, we examined the relations between dimensions of attachment and emotion regulation behaviors, turnover intentions, and supervisory reports of counterproductive work behavior and organizational citizenship behavior. Results showed that anxiety and avoidance represent 2 higher order dimensions of attachment that predicted these criteria (except for counterproductive work behavior) after controlling for individual difference variables and organizational commitment. The implications of these results for the study of attachment at work are discussed.

  18. A Theory for the Function of the Spermaceti Organ of the Sperm Whale (Physeter Catodon L.)

    NASA Technical Reports Server (NTRS)

    Norris, K. S.; Harvey, G. W.

    1972-01-01

    The function of the spermaceti organ of the sperm whale is studied using a model of its acoustic system. Suggested functions of the system include: (1) action as an acoustic resonating and sound focussing chamber to form and process burst-pulsed clicks; (2) use of nasal passages in forehead for repeated recycling of air for phonation during dives and to provide mirrors for sound reflection and signal processing; and (3) use of the entire system to allow sound signal production especially useful for long range echolocofion in the deep sea.

  19. Electronic, optical, and spectroscopic analysis of TBADN organic semiconductor: Experiment and theory

    NASA Astrophysics Data System (ADS)

    Orek, Cahit; Gündüz, Bayram; Kaygili, Omer; Bulut, Niyazi

    2017-06-01

    In this study, the electronic, optical and spectroscopic properties of 2-tert-Butyl-9,10-di(naphth-2-yl) anthracene (TBADN) semiconductor in different solvents were investigated by experimentally and computationally. Obtained theoretical and experimental UV-VIS spectra of the TBADN were found to be quite in good agreement and can be controlled with various solvents. Refractive index values of the TBADN semiconductor in different solvents were experimentally measured and calculated theoretically. Finally, the FTIR spectra of the TBADN organic semiconductor in different solvents were investigated by theoretical and experimental methods. It was found that the band gap is sensitive to the concentration of the solute.

  20. 76 FR 23801 - North American Electric Reliability Corporation; Order Approving Reliability Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... Energy Regulatory Commission North American Electric Reliability Corporation; Order Approving Reliability..., John R. Norris, and Cheryl A. LaFleur. 1. On February 11, 2011, the North American Electric Reliability Corporation (NERC), the Commission-certified Electric Reliability Organization (ERO), submitted a petition for...

  1. Predicting intentions to purchase organic food: the role of affective and moral attitudes in the Theory of Planned Behaviour.

    PubMed

    Arvola, A; Vassallo, M; Dean, M; Lampila, P; Saba, A; Lähteenmäki, L; Shepherd, R

    2008-01-01

    This study examined the usefulness of integrating measures of affective and moral attitudes into the Theory of Planned Behaviour (TPB)-model in predicting purchase intentions of organic foods. Moral attitude was operationalised as positive self-rewarding feelings of doing the right thing. Questionnaire data were gathered in three countries: Italy (N=202), Finland (N=270) and UK (N=200) in March 2004. Questions focussed on intentions to purchase organic apples and organic ready-to-cook pizza instead of their conventional alternatives. Data were analysed using Structural Equation Modelling by simultaneous multi-group analysis of the three countries. Along with attitudes, moral attitude and subjective norms explained considerable shares of variances in intentions. The relative influences of these variables varied between the countries, such that in the UK and Italy moral attitude rather than subjective norms had stronger explanatory power. In Finland it was other way around. Inclusion of moral attitude improved the model fit and predictive ability of the model, although only marginally in Finland. Thus the results partially support the usefulness of incorporating moral measures as well as affective items for attitude into the framework of TPB.

  2. Predicting organic food consumption: A meta-analytic structural equation model based on the theory of planned behavior.

    PubMed

    Scalco, Andrea; Noventa, Stefano; Sartori, Riccardo; Ceschi, Andrea

    2017-05-01

    During the last decade, the purchase of organic food within a sustainable consumption context has gained momentum. Consequently, the amount of research in the field has increased, leading in some cases to discrepancies regarding both methods and results. The present review examines those works that applied the theory of planned behavior (TPB; Ajzen, 1991) as a theoretical framework in order to understand and predict consumers' motivation to buy organic food. A meta-analysis has been conducted to assess the strength of the relationships between attitude, subjective norms, perceived behavioral control, and intention, as well as between intention and behavior. Results confirm the major role played by individual attitude in shaping buying intention, followed by subjective norms and perceived behavioral control. Intention-behavior shows a large effect size, few studies however explicitly reported such an association. Furthermore, starting from a pooled correlation matrix, a meta-analytic structural equation model has been applied to jointly evaluate the strength of the relationships among the factors of the original model. Results suggest the robustness of the TPB model. In addition, mediation analysis indicates a potential direct effect from subjective norms to individual attitude in the present context. Finally, some issues regarding methodological aspects of the application of the TPB within the context of organic food are discussed for further research developments. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Unveiling Adsorption Mechanisms of Organic Pollutants onto Carbon Nanomaterials by Density Functional Theory Computations and Linear Free Energy Relationship Modeling.

    PubMed

    Wang, Ya; Chen, Jingwen; Wei, Xiaoxuan; Hernandez Maldonado, Arturo J; Chen, Zhongfang

    2017-10-02

    Predicting adsorption of organic pollutants onto carbon nanomaterials (CNMs) and understanding the adsorption mechanisms are of great importance to assess the environmental behavior and ecological risks of organic pollutants and CNMs. By means of density functional theory (DFT) computations, we investigated the adsorption of 38 organic molecules (aliphatic hydrocarbons, benzene and its derivatives, and polycyclic aromatic hydrocarbons) onto pristine graphene in both gaseous and aqueous phases. Polyparameter linear free energy relationships (pp-LFERs) were developed, which can be employed to predict adsorption energies of aliphatic and aromatic hydrocarbons on graphene. Based on the pp-LFERs, contributions of different interactions to the overall adsorption were estimated. As suggested by the pp-LFERs, the gaseous adsorption energies are mainly governed by dispersion and electrostatic interactions, while the aqueous adsorption energies are mainly determined by dispersion and hydrophobic interactions. It was also revealed that curvature of single-walled carbon nanotubes (SWNTs) exhibits more significant effects than the electronic properties (metallic or semiconducting) on gaseous adsorption energies, and graphene has stronger adsorption abilities than SWNTs. The developed models may pave a promising way for predicting adsorption of environmental chemicals onto CNMs with in silico techniques.

  4. Density functional theory study on electron and hole transport properties of organic pentacene derivatives with electron-withdrawing substituent.

    PubMed

    Chai, Shuo; Wen, Shu-Hao; Huang, Jin-Dou; Han, Ke-Li

    2011-11-30

    Attaching electron-withdrawing substituent to organic conjugated molecules is considered as an effective method to produce n-type and ambipolar transport materials. In this work, we use density functional theory calculations to investigate the electron and hole transport properties of pentacene (PENT) derivatives after substituent and simulate the angular resolution anisotropic mobility for both electron and hole transport. Our results show that adding electron-withdrawing substituents can lower the energy level of lowest unoccupied molecular orbital (LUMO) and increase electron affinity, which are beneficial to the electron injection and ambient stability of the material. Also the LUMO electronic couplings for electron transport in these pentacene derivatives can achieve up to a hundred meV which promises good electron transport mobility, although adding electron-withdrawing groups will introduce the increase of electron transfer reorganization energy. The final results of our angular resolution anisotropic mobility simulations show that the electron mobility of these pentacene derivatives can get to several cm(2) V(-1) s(-1), but it is important to control the orientation of the organic material relative to the device channel to obtain the highest electron mobility. Our investigation provide detailed information to assist in the design of n-type and ambipolar organic electronic materials with high mobility performance. Copyright © 2011 Wiley Periodicals, Inc.

  5. Local electronic structure and nanolevel hierarchical organization of bone tissue: theory and NEXAFS study

    NASA Astrophysics Data System (ADS)

    Pavlychev, A. A.; Avrunin, A. S.; Vinogradov, A. S.; Filatova, E. O.; Doctorov, A. A.; Krivosenko, Yu S.; Samoilenko, D. O.; Svirskiy, G. I.; Konashuk, A. S.; Rostov, D. A.

    2016-12-01

    Theoretical and experimental investigations of native bone are carried out to understand relationships between its hierarchical organization and local electronic and atomic structure of the mineralized phase. The 3D superlattice model of a coplanar assembly of the hydroxyapatite (HAP) nanocrystallites separated by the hydrated nanolayers is introduced to account the interplay of short-, long- and super-range order parameters in bone tissue. The model is applied to (i) predict and rationalize the HAP-to-bone spectral changes in the electronic structure and (ii) describe the mechanisms ensuring the link of the hierarchical organization with the electronic structure of the mineralized phase in bone. To check the predictions the near-edge x-ray absorption fine structure (NEXAFS) at the Ca 2p, P 2p and O 1s thresholds is measured for native bone and compared with NEXAFS for reference compounds. The NEXAFS analysis has demonstrated the essential hierarchy induced HAP-to-bone red shifts of the Ca and P 2p-to-valence transitions. The lowest O 1s excitation line at 532.2 eV in bone is assigned with superposition of core transitions in the hydroxide OH-(H2O) m anions, Ca2+(H2O) n cations, the carboxyl groups inside the collagen and [PO4]2- and [PO4]- anions with unsaturated P-O bonds.

  6. 75 FR 68780 - Reliability Monitoring, Enforcement and Compliance Issues; Agenda for the Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... Electric Reliability Organization (ERO), and performance by the Regional Entities, under their delegation agreements with the ERO.\\1\\ \\1\\ North American Electric Reliability Corporation; Reliability Standards...

  7. Vicinal 1H-1H NMR coupling constants from density functional theory as reliable tools for stereochemical analysis of highly flexible multichiral center molecules.

    PubMed

    López-Vallejo, Fabian; Fragoso-Serrano, Mabel; Suárez-Ortiz, Gloria Alejandra; Hernández-Rojas, Adriana C; Cerda-García-Rojas, Carlos M; Pereda-Miranda, Rogelio

    2011-08-05

    A protocol for stereochemical analysis, based on the systematic comparison between theoretical and experimental vicinal (1)H-(1)H NMR coupling constants, was developed and applied to a series of flexible compounds (1-8) derived from the 6-heptenyl-5,6-dihydro-2H-pyran-2-one framework. The method included a broad conformational search, followed by geometry optimization at the DFT B3LYP/DGDZVP level, calculation of the vibrational frequencies, thermochemical parameters, magnetic shielding tensors, and the total NMR spin-spin coupling constants. Three scaling factors, depending on the carbon atom hybridizations, were found for the (1)H-C-C-(1)H vicinal coupling constants: f((sp3)-(sp3)) = 0.910, f((sp3)-(sp2)) = 0.929, and f((sp2)-(sp2))= 0.977. A remarkable correlation between the theoretical (J(pre)) and experimental (1)H-(1)H NMR (J(exp)) coupling constants for spicigerolide (1), a cytotoxic natural product, and some of its synthetic stereoisomers (2-4) demonstrated the predictive value of this approach for the stereochemical assignment of highly flexible compounds containing multiple chiral centers. The stereochemistry of two natural 6-heptenyl-5,6-dihydro-2H-pyran-2-ones (14 and 15) containing diverse functional groups in the heptenyl side chain was also analyzed by application of this combined theoretical and experimental approach, confirming its reliability. Additionally, a geometrical analysis for the conformations of 1-8 revealed that weak hydrogen bonds substantially guide the conformational behavior of the tetraacyloxy-6-heptenyl-2H-pyran-2-ones.

  8. Mean-field theory of atomic self-organization in optical cavities

    NASA Astrophysics Data System (ADS)

    Jäger, Simon B.; Schütz, Stefan; Morigi, Giovanna

    2016-08-01

    Photons mediate long-range optomechanical forces between atoms in high-finesse resonators, which can induce the formation of ordered spatial patterns. When a transverse laser drives the atoms, the system undergoes a second-order phase transition that separates a uniform spatial density from a Bragg grating maximizing scattering into the cavity and is controlled by the laser intensity. Starting from a Fokker-Planck equation describing the semiclassical dynamics of the N -atom distribution function, we systematically develop a mean-field model and analyze its predictions for the equilibrium and out-of-equilibrium dynamics. The validity of the mean-field model is tested by comparison with the numerical simulations of the N -body Fokker-Planck equation and by means of a Bogoliubov-Born-Green-Kirkwood-Yvon (BBGKY) hierarchy. The mean-field theory predictions well reproduce several results of the N -body Fokker-Planck equation for sufficiently short times and are in good agreement with existing theoretical approaches based on field-theoretical models. The mean field, on the other hand, predicts thermalization time scales which are at least one order of magnitude shorter than the ones predicted by the N -body dynamics. We attribute this discrepancy to the fact that the mean-field ansatz discards the effects of the long-range incoherent forces due to cavity losses.

  9. The metabolic pace-of-life model: incorporating ectothermic organisms into the theory of vertebrate ecoimmunology.

    PubMed

    Sandmeier, Franziska C; Tracy, Richard C

    2014-09-01

    We propose a new heuristic model that incorporates metabolic rate and pace of life to predict a vertebrate species' investment in adaptive immune function. Using reptiles as an example, we hypothesize that animals with low metabolic rates will invest more in innate immunity compared with adaptive immunity. High metabolic rates and body temperatures should logically optimize the efficacy of the adaptive immune system--through rapid replication of T and B cells, prolific production of induced antibodies, and kinetics of antibody--antigen interactions. In current theory, the precise mechanisms of vertebrate immune function oft are inadequately considered as diverse selective pressures on the evolution of pathogens. We propose that the strength of adaptive immune function and pace of life together determine many of the important dynamics of host-pathogen evolution, namely, that hosts with a short lifespan and innate immunity or with a long lifespan and strong adaptive immunity are expected to drive the rapid evolution of their populations of pathogens. Long-lived hosts that rely primarily on innate immune functions are more likely to use defense mechanisms of tolerance (instead of resistance), which are not expected to act as a selection pressure for the rapid evolution of pathogens' virulence.

  10. Beyond frontier molecular orbital theory: a systematic electron transfer model (ETM) for polar bimolecular organic reactions.

    PubMed

    Cahill, Katharine J; Johnson, Richard P

    2013-03-01

    Polar bimolecular reactions often begin as charge-transfer complexes and may proceed with a high degree of electron transfer character. Frontier molecular orbital (FMO) theory is predicated in part on this concept. We have developed an electron transfer model (ETM) in which we systematically transfer one electron between reactants and then use density functional methods to model the resultant radical or radical ion intermediates. Sites of higher reactivity are revealed by a composite spin density map (SDM) of odd electron character on the electron density surface, assuming that a new two-electron bond would occur preferentially at these sites. ETM correctly predicts regio- and stereoselectivity for a broad array of reactions, including Diels-Alder, dipolar and ketene cycloadditions, Birch reduction, many types of nucleophilic additions, and electrophilic addition to aromatic rings and polyenes. Conformational analysis of radical ions is often necessary to predict reaction stereochemistry. The electronic and geometric changes due to one-electron oxidation or reduction parallel the reaction coordinate for electrophilic or nucleophilic addition, respectively. The effect is more dramatic for one-electron reduction.

  11. From organized high throughput data to phenomenological theory: The example of dielectric breakdown

    NASA Astrophysics Data System (ADS)

    Kim, Chiho; Pilania, Ghanshyam; Ramprasad, Rampi

    Understanding the behavior (and failure) of dielectric insulators experiencing extreme electric fields is critical to the operation of present and emerging electrical and electronic devices. Despite its importance, the development of a predictive theory of dielectric breakdown has remained a challenge, owing to the complex multiscale nature of this process. Here, we focus on the intrinsic dielectric breakdown field of insulators--the theoretical limit of breakdown determined purely by the chemistry of the material, i.e., the elements the material is composed of, the atomic-level structure, and the bonding. Starting from a benchmark dataset (generated from laborious first principles computations) of the intrinsic dielectric breakdown field of a variety of model insulators, simple predictive phenomenological models of dielectric breakdown are distilled using advanced statistical or machine learning schemes, revealing key correlations and analytical relationships between the breakdown field and easily accessible material properties. The models are shown to be general, and can hence guide the screening and systematic identification of high electric field tolerant materials.

  12. Leadership in nonprofit organizations of Nicaragua and El Salvador: a study from the social identity theory.

    PubMed

    Moriano León, Juan Antonio; Topa Cantisano, Gabriela; Lévy Mangin, Jean-Pierre

    2009-11-01

    This study follows the social identity model of leadership proposed by van Knippenberg and Hogg (2003), in order to examine empirically the mediator effect of leadership prototypicality between social identity, extra effort, and perceived effectiveness of group members. The sample consisted of 109 participants who worked in 22 different work-teams of non-profit organizations (NPO) from Nicaragua and El Salvador. The data analysis was performed through structural equation modeling (SEM). The results show that NPO membership is related to a high level of social identity. In addition, the results confirmed that leadership prototypicality has a significant and positive mediator effect in the relationship between the group identification and the group members' extra effort and the perceived effectiveness of leadership.

  13. Computational organic chemistry: bridging theory and experiment in establishing the mechanisms of chemical reactions.

    PubMed

    Cheng, Gui-Juan; Zhang, Xinhao; Chung, Lung Wa; Xu, Liping; Wu, Yun-Dong

    2015-02-11

    Understanding the mechanisms of chemical reactions, especially catalysis, has been an important and active area of computational organic chemistry, and close collaborations between experimentalists and theorists represent a growing trend. This Perspective provides examples of such productive collaborations. The understanding of various reaction mechanisms and the insight gained from these studies are emphasized. The applications of various experimental techniques in elucidation of reaction details as well as the development of various computational techniques to meet the demand of emerging synthetic methods, e.g., C-H activation, organocatalysis, and single electron transfer, are presented along with some conventional developments of mechanistic aspects. Examples of applications are selected to demonstrate the advantages and limitations of these techniques. Some challenges in the mechanistic studies and predictions of reactions are also analyzed.

  14. Information and Theory of Organizations as a Conceptual Framework for System Design of Automated Medical Information Systems

    PubMed Central

    Fuchs-Kittowski, K.

    1982-01-01

    To this date the design of hospital information systems has been the province of hardware and software specialists. The theories of information and social organizations can contribute to the design of information systems by stressing the principles of formalization and the differences between routine and non-routine tasks, with their accompanying effect on worker satisfaction and organizational efficiency. In particular, the difference between the needs of research hospitals and care hospitals will be discussed. Note: This is an edited version of the longer paper prepared by Professor Fuchs-Kittowski. The editing was done by Vincent Brannigan of the University of Maryland. Professor Fuchs-Kittowski was unable to review the edited version, so this version should not be quoted without reference to the original paper. Please contact Professor Brannigan for a copy of the original paper. All citations are those of the original paper.

  15. Theory of Current Transients in Planar Semiconductor Devices: Insights and Applications to Organic Solar Cells

    NASA Astrophysics Data System (ADS)

    Hawks, Steven A.; Finck, Benjamin Y.; Schwartz, Benjamin J.

    2015-04-01

    Time-domain current measurements are widely used to characterize semiconductor material properties, such as carrier mobility, doping concentration, carrier lifetime, and the static dielectric constant. It is therefore critical that these measurements be theoretically understood if they are to be successfully applied to assess the properties of materials and devices. In this paper, we derive generalized relations for describing current-density transients in planar semiconductor devices at uniform temperature. By spatially averaging the charge densities inside the semiconductor, we are able to provide a rigorous, straightforward, and experimentally relevant way to interpret these measurements. The formalism details several subtle aspects of current transients, including how the electrode charge relates to applied bias and internal space charge, how the displacement current can alter the apparent free-carrier current, and how to understand the integral of a charge-extraction transient. We also demonstrate how the formalism can be employed to derive the current transients arising from simple physical models, like those used to describe charge extraction by linearly increasing voltage (CELIV) and time-of-flight experiments. In doing so, we find that there is a nonintuitive factor-of-2 reduction in the apparent free-carrier concentration that can be easily missed, for example, in the application of charge-extraction models. Finally, to validate our theory and better understand the different current contributions, we perform a full time-domain drift-diffusion simulation of a CELIV trace and compare the results to our formalism. As expected, our analytic equations match precisely with the numerical solutions to the drift-diffusion, Poisson, and continuity equations. Thus, overall, our formalism provides a straightforward and general way to think about how the internal space-charge distribution, the electrode charge, and the externally applied bias translate into a measured

  16. Disrupted Brain Functional Organization in Epilepsy Revealed by Graph Theory Analysis.

    PubMed

    Song, Jie; Nair, Veena A; Gaggl, Wolfgang; Prabhakaran, Vivek

    2015-06-01

    The human brain is a complex and dynamic system that can be modeled as a large-scale brain network to better understand the reorganizational changes secondary to epilepsy. In this study, we developed a brain functional network model using graph theory methods applied to resting-state fMRI data acquired from a group of epilepsy patients and age- and gender-matched healthy controls. A brain functional network model was constructed based on resting-state functional connectivity. A minimum spanning tree combined with proportional thresholding approach was used to obtain sparse connectivity matrices for each subject, which formed the basis of brain networks. We examined the brain reorganizational changes in epilepsy thoroughly at the level of the whole brain, the functional network, and individual brain regions. At the whole-brain level, local efficiency was significantly decreased in epilepsy patients compared with the healthy controls. However, global efficiency was significantly increased in epilepsy due to increased number of functional connections between networks (although weakly connected). At the functional network level, there were significant proportions of newly formed connections between the default mode network and other networks and between the subcortical network and other networks. There was a significant proportion of decreasing connections between the cingulo-opercular task control network and other networks. Individual brain regions from different functional networks, however, showed a distinct pattern of reorganizational changes in epilepsy. These findings suggest that epilepsy alters brain efficiency in a consistent pattern at the whole-brain level, yet alters brain functional networks and individual brain regions differently.

  17. Item response theory analysis to evaluate reliability and minimal clinically important change of the Roland-Morris Disability Questionnaire in patients with severe disability due to back pain from vertebral compression fractures.

    PubMed

    Lee, Minji K; Yost, Kathleen J; McDonald, Jennifer S; Dougherty, Ryne W; Vine, Roanna L; Kallmes, David F

    2017-06-01

    The majority of validation done on the Roland-Morris Disability Questionnaire (RMDQ) has been in patients with mild or moderate disability. There is paucity of research focusing on the psychometric quality of the RMDQ in patients with severe disability. To evaluate the psychometric quality of the RMDQ in patients with severe disability. Observational clinical study. The sample consisted of 214 patients with painful vertebral compression fractures who underwent vertebroplasty or kyphoplasty. The 23-item version of the RMDQ was completed at two time points: baseline and 30-day postintervention follow-up. With the two-parameter logistic unidimensional item response theory (IRT) analyses, we derived the range of scores that produced reliable measurement and investigated the minimal clinically important difference (MCID). Scores for 214 (100%) patients at baseline and 108 (50%) patients at follow-up did not meet the reliability criterion of 0.90 or higher, with the majority of patients having disability due to back pain that was too severe to be reliably measured by the RMDQ. Depending on methodology, MCID estimates ranged from 2 to 8 points and the proportion of patients classified as having experienced meaningful improvement ranged from 26% to 68%. A greater change in score was needed at the extreme ends of the score scale to be classified as having achieved MCID using IRT methods. Replacing items measuring moderate disability with items measuring severe disability could yield a version of the RMDQ that better targets patients with severe disability due to back pain. Improved precision in measuring disability would be valuable to clinicians who treat patients with greater functional impairments. Caution is needed when choosing criteria for interpreting meaningful change using the RMDQ. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Waste package reliability analysis

    SciTech Connect

    Pescatore, C.; Sastre, C.

    1983-01-01

    Proof of future performance of a complex system such as a high-level nuclear waste package over a period of hundreds to thousands of years cannot be had in the ordinary sense of the word. The general method of probabilistic reliability analysis could provide an acceptable framework to identify, organize, and convey the information necessary to satisfy the criterion of reasonable assurance of waste package performance according to the regulatory requirements set forth in 10 CFR 60. General principles which may be used to evaluate the qualitative and quantitative reliability of a waste package design are indicated and illustrated with a sample calculation of a repository concept in basalt. 8 references, 1 table.

  19. Theory of magnetoresistance of organic molecular tunnel junctions with nonmagnetic electrodes

    NASA Astrophysics Data System (ADS)

    Shi, Sha; Xie, Zuoti; Liu, Feilong; Smith, Darryl L.; Frisbie, C. Daniel; Ruden, P. Paul

    2017-04-01

    Large room-temperature magnetoresistance observed for devices composed of self-assembled monolayers of different oligophenylene thiols sandwiched between gold contacts has recently been reported [Z. Xie, S. Shi, F. Liu, D. L. Smith, P. P. Ruden, and C. D. Frisbie, ACS Nano 10, 8571 (2016), 10.1021/acsnano.6b03853]. The transport mechanism through the organic molecules was determined to be nonresonant tunneling. To explain this kind of magnetoresistance, we develop an analytical model based on the interaction of the tunneling charge carrier with an unpaired charge carrier populating a contact-molecule interface state. The Coulomb interaction between carriers causes the transmission coefficients to depend on their relative spin orientation. Singlet and triplet pairing of the tunneling and the interface carriers thus correspond to separate conduction channels with different transmission probabilities. Spin relaxation enabling transitions between the different channels, and therefore tending to maximize the tunneling current for a given applied bias, can be suppressed by relatively small magnetic fields, leading to large magnetoresistance. Our model elucidates how the Coulomb interaction gives rise to transmission probabilities that depend on spin and how an applied magnetic field can inhibit transitions between different spin configurations.

  20. The semantic organization of the animal category: evidence from semantic verbal fluency and network theory.

    PubMed

    Goñi, Joaquín; Arrondo, Gonzalo; Sepulcre, Jorge; Martincorena, Iñigo; Vélez de Mendizábal, Nieves; Corominas-Murtra, Bernat; Bejarano, Bartolomé; Ardanza-Trevijano, Sergio; Peraita, Herminia; Wall, Dennis P; Villoslada, Pablo

    2011-05-01

    Semantic memory is the subsystem of human memory that stores knowledge of concepts or meanings, as opposed to life-specific experiences. How humans organize semantic information remains poorly understood. In an effort to better understand this issue, we conducted a verbal fluency experiment on 200 participants with the aim of inferring and representing the conceptual storage structure of the natural category of animals as a network. This was done by formulating a statistical framework for co-occurring concepts that aims to infer significant concept-concept associations and represent them as a graph. The resulting network was analyzed and enriched by means of a missing links recovery criterion based on modularity. Both network models were compared to a thresholded co-occurrence approach. They were evaluated using a random subset of verbal fluency tests and comparing the network outcomes (linked pairs are clustering transitions and disconnected pairs are switching transitions) to the outcomes of two expert human raters. Results show that the network models proposed in this study overcome a thresholded co-occurrence approach, and their outcomes are in high agreement with human evaluations. Finally, the interplay between conceptual structure and retrieval mechanisms is discussed.

  1. Understanding Small-Molecule Interactions in Metal-Organic Frameworks: Coupling Experiment with Theory.

    PubMed

    Lee, Jason S; Vlaisavljevich, Bess; Britt, David K; Brown, Craig M; Haranczyk, Maciej; Neaton, Jeffrey B; Smit, Berend; Long, Jeffrey R; Queen, Wendy L

    2015-10-14

    Metal-organic frameworks (MOFs) have gained much attention as next-generation porous media for various applications, especially gas separation/storage, and catalysis. New MOFs are regularly reported; however, to develop better materials in a timely manner for specific applications, the interactions between guest molecules and the internal surface of the framework must first be understood. A combined experimental and theoretical approach is presented, which proves essential for the elucidation of small-molecule interactions in a model MOF system known as M2 (dobdc) (dobdc(4-) = 2,5-dioxido-1,4-benzenedicarboxylate; M = Mg, Mn, Fe, Co, Ni, Cu, or Zn), a material whose adsorption properties can be readily tuned via chemical substitution. It is additionally shown that the study of extensive families like this one can provide a platform to test the efficacy and accuracy of developing computational methodologies in slightly varying chemical environments, a task that is necessary for their evolution into viable, robust tools for screening large numbers of materials. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Sub-bandgap absorption in organic solar cells: experiment and theory.

    PubMed

    Beenken, Wichard J D; Herrmann, Felix; Presselt, Martin; Hoppe, Harald; Shokhovets, Sviatoslav; Gobsch, Gerhard; Runge, Erich

    2013-10-21

    Most high-performance organic solar cells involve bulk-heterojunctions in order to increase the active donor-acceptor interface area. The power conversion efficiency depends critically on the nano-morphology of the blend and the interface. Spectroscopy of the sub-bandgap region, i.e., below the bulk absorption of the individual components, provides unique opportunities to study interface-related properties. We present absorption measurements in the sub-bandgap region of bulk heterojunctions made of poly(3-hexylthiophene-2,5-diyl) as an electron donor and [6,6]-phenyl-C61-butyric acid methyl ester (P3HT:PCBM) as an electron acceptor and compare them with quantum-chemical calculations and recently published data on the external quantum efficiency (EQE). The very weak absorption of the deep sub-bandgap region measured by the ultra-sensitive Photothermal Deflection Spectroscopy (PDS) features Urbach tails, polaronic transitions, conventional excitons, and possibly charge-transfer states. The quantum-chemical calculations allow characterizing some of the unsettled spectral features.

  3. Charge Photogeneration Experiments and Theory in Aggregated Squaraine Donor Materials for Improved Organic Solar Cell Efficiencies

    NASA Astrophysics Data System (ADS)

    Spencer, Susan Demetra

    Fossil fuel consumption has a deleterious effect on humans, the economy, and the environment. Renewable energy technologies must be identified and commercialized as quickly as possible so that the transition to renewables can happen at a minimum of financial and societal cost. Organic photovoltaic cells offer an inexpensive and disruptive energy technology, if the scientific challenges of understanding charge photogeneration in a bulk heterojunction material can be overcome. At RIT, there is a strong focus on creating new materials that can both offer fundamentally important scientific results relating to quantum photophysics, and simultaneously assist in the development of strong candidates for future commercialized technology. In this presentation, the results of intensive materials characterization of a series of squaraine small molecule donors will be presented, as well as a full study of the fabrication and optimization required to achieve >4% photovoltaic cell efficiency. A relationship between the molecular structure of the squaraine and its ability to form nanoscale aggregates will be explored. Squaraine aggregation will be described as a unique optoelectronic probe of the structure of the bulk heterojunction. This relationship will then be utilized to explain changes in crystallinity that impact the overall performance of the devices. Finally, a predictive summary will be given for the future of donor material research at RIT.

  4. 78 FR 63036 - Transmission Planning Reliability Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Standard TPL-001-4, submitted by the North American Electric Reliability Corporation, the Commission-certified Electric Reliability Organization. Reliability Standard TPL-001-4 introduces significant revisions... permissible use of planned non-consequential load loss to address bulk electric system performance issues...

  5. Reliability science and patient safety.

    PubMed

    Luria, Joseph W; Muething, Stephen E; Schoettker, Pamela J; Kotagal, Uma R

    2006-12-01

    Reliability is failure-free operation over time--the measurable capability of a process, procedure, or service to perform its intended function. Reliability science has the potential to help health care organizations reduce defects in care, increase the consistency with which care is delivered, and improve patient outcomes. Based on its principles, the Institute for Health care Improvement has developed a three-step model to prevent failures, mitigate the failures that occur, and redesign systems to reduce failures. Lessons may also be learned from complex organizations that have already adopted the principles of reliability science and operate with high rates of reliability. They share a preoccupation with failure, reluctance to simplify interpretations, sensitivity to operations, commitment to resilience, and underspecification of structures.

  6. Probing Adsorption Interactions In Metal-Organic Frameworks Using X-ray Spectroscopy and Density Functional Theory

    NASA Astrophysics Data System (ADS)

    Drisdell, Walter; Poloni, Roberta; McDonald, Thomas; Long, Jeffrey; Smit, Berend; Neaton, Jeffrey; Prendergast, David; Kortright, Jeffrey

    2014-03-01

    Metal-organic frameworks (MOFs) are currently among the most promising materials for gas separation applications such as carbon capture. We explore the local electronic signatures of molecular adsorption at coordinatively unsaturated binding sites in the metal-organic framework Mg-MOF-74 using X-ray spectroscopy and first principles calculations. In situ measurements at the Mg K-edge reveal distinct pre-edge absorption features associated with the unique, open coordination of the Mg sites. These spectral features are suppressed upon adsorption of CO2 and N ,N' -dimethylformamide. Density functional theory shows that these spectral changes arise from modifications of local symmetry around the Mg sites upon gas uptake and are strongly dependent on the metal-adsorbate binding strength. Similar sensitivity to local symmetry is expected for any open metal site, making X-ray spectroscopy an ideal tool for examining adsorption in such MOFs. This work was supported by the Center for Gas Separations Relevant to Clean Energy Technologies, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DE-SC0001015

  7. Fatigue properties of atomic-layer-deposited alumina ultra-barriers and their implications for the reliability of flexible organic electronics

    SciTech Connect

    Baumert, E. K.; Pierron, O. N.

    2012-12-17

    The fatigue degradation properties of atomic-layer-deposited alumina, with thickness ranging from 4.2 to 50 nm, were investigated using a silicon micro-resonator on which the coatings were deposited and strained in a static or cyclic manner, with strain amplitudes up to 2.2%, in controlled environments. Based on the measured resonant frequency evolution, post-test scanning electron microscopy observations, and finite element models, it is shown that cracks in the alumina nucleate and propagate under cyclic loading, and that the crack growth rates scale with the strain energy release rates for crack channeling. The implications for the reliability of flexible electronics are discussed.

  8. Organics.

    ERIC Educational Resources Information Center

    Chian, Edward S. K.; DeWalle, Foppe B.

    1978-01-01

    Presents water analysis literature for 1978. This review is concerned with organics, and it covers: (1) detergents and surfactants; (2) aliphatic and aromatic hydrocarbons; (3) pesticides and chlorinated hydrocarbons; and (4) naturally occurring organics. A list of 208 references is also presented. (HM)

  9. Organics.

    ERIC Educational Resources Information Center

    Chian, Edward S. K.; DeWalle, Foppe B.

    1978-01-01

    Presents water analysis literature for 1978. This review is concerned with organics, and it covers: (1) detergents and surfactants; (2) aliphatic and aromatic hydrocarbons; (3) pesticides and chlorinated hydrocarbons; and (4) naturally occurring organics. A list of 208 references is also presented. (HM)

  10. Kleiber's Law: How the Fire of Life ignited debate, fueled theory, and neglected plants as model organisms.

    PubMed

    Niklas, Karl J; Kutschera, Ulrich

    2015-01-01

    Size is a key feature of any organism since it influences the rate at which resources are consumed and thus affects metabolic rates. In the 1930s, size-dependent relationships were codified as "allometry" and it was shown that most of these could be quantified using the slopes of log-log plots of any 2 variables of interest. During the decades that followed, physiologists explored how animal respiration rates varied as a function of body size across taxa. The expectation was that rates would scale as the 2/3 power of body size as a reflection of the Euclidean relationship between surface area and volume. However, the work of Max Kleiber (1893-1976) and others revealed that animal respiration rates apparently scale more closely as the 3/4 power of body size. This phenomenology, which is called "Kleiber's Law," has been described for a broad range of organisms, including some algae and plants. It has also been severely criticized on theoretical and empirical grounds. Here, we review the history of the analysis of metabolism, which originated with the works of Antoine L. Lavoisier (1743-1794) and Julius Sachs (1832-1897), and culminated in Kleiber's book The Fire of Life (1961; 2. ed. 1975). We then evaluate some of the criticisms that have been leveled against Kleiber's Law and some examples of the theories that have tried to explain it. We revive the speculation that intracellular exo- and endocytotic processes are resource delivery-systems, analogous to the supercellular systems in multicellular organisms. Finally, we present data that cast doubt on the existence of a single scaling relationship between growth and body size in plants.

  11. Kleiber's Law: How the Fire of Life ignited debate, fueled theory, and neglected plants as model organisms

    PubMed Central

    Niklas, Karl J; Kutschera, Ulrich

    2015-01-01

    Size is a key feature of any organism since it influences the rate at which resources are consumed and thus affects metabolic rates. In the 1930s, size-dependent relationships were codified as “allometry” and it was shown that most of these could be quantified using the slopes of log-log plots of any 2 variables of interest. During the decades that followed, physiologists explored how animal respiration rates varied as a function of body size across taxa. The expectation was that rates would scale as the 2/3 power of body size as a reflection of the Euclidean relationship between surface area and volume. However, the work of Max Kleiber (1893–1976) and others revealed that animal respiration rates apparently scale more closely as the 3/4 power of body size. This phenomenology, which is called “Kleiber's Law,” has been described for a broad range of organisms, including some algae and plants. It has also been severely criticized on theoretical and empirical grounds. Here, we review the history of the analysis of metabolism, which originated with the works of Antoine L. Lavoisier (1743–1794) and Julius Sachs (1832–1897), and culminated in Kleiber's book The Fire of Life (1961; 2. ed. 1975). We then evaluate some of the criticisms that have been leveled against Kleiber's Law and some examples of the theories that have tried to explain it. We revive the speculation that intracellular exo- and endocytotic processes are resource delivery-systems, analogous to the supercellular systems in multicellular organisms. Finally, we present data that cast doubt on the existence of a single scaling relationship between growth and body size in plants. PMID:26156204

  12. Reliability and Maintainability (RAM) Training

    NASA Technical Reports Server (NTRS)

    Lalli, Vincent R. (Editor); Malec, Henry A. (Editor); Packard, Michael H. (Editor)

    2000-01-01

    The theme of this manual is failure physics-the study of how products, hardware, software, and systems fail and what can be done about it. The intent is to impart useful information, to extend the limits of production capability, and to assist in achieving low-cost reliable products. In a broader sense the manual should do more. It should underscore the urgent need CI for mature attitudes toward reliability. Five of the chapters were originally presented as a classroom course to over 1000 Martin Marietta engineers and technicians. Another four chapters and three appendixes have been added, We begin with a view of reliability from the years 1940 to 2000. Chapter 2 starts the training material with a review of mathematics and a description of what elements contribute to product failures. The remaining chapters elucidate basic reliability theory and the disciplines that allow us to control and eliminate failures.

  13. Standardized Conditional "SEM": A Case for Conditional Reliability

    ERIC Educational Resources Information Center

    Raju, Nambury S.; Price, Larry R.; Oshima, T. C.; Nering, Michael L.

    2007-01-01

    An examinee-level (or conditional) reliability is proposed for use in both classical test theory (CTT) and item response theory (IRT). The well-known group-level reliability is shown to be the average of conditional reliabilities of examinees in a group or a population. This relationship is similar to the known relationship between the square of…

  14. Packaging Theory.

    ERIC Educational Resources Information Center

    Williams, Jeffrey

    1994-01-01

    Considers the recent flood of anthologies of literary criticism and theory as exemplifications of the confluence of pedagogical concerns, economics of publishing, and other historical factors. Looks specifically at how these anthologies present theory. Cites problems with their formatting theory and proposes alternative ways of organizing theory…

  15. Reliability computation from reliability block diagrams

    NASA Technical Reports Server (NTRS)

    Chelson, P. O.; Eckstein, E. Y.

    1975-01-01

    Computer program computes system reliability for very general class of reliability block diagrams. Four factors are considered in calculating probability of system success: active block redundancy, standby block redundancy, partial redundancy, and presence of equivalent blocks in the diagram.

  16. Reliability and Validity of the World Health Organization Quality of Life: Brief Version (WHOQOL-BREF) in a Homeless Substance Dependent Veteran Population

    ERIC Educational Resources Information Center

    Garcia-Rea, Elizabeth A.; LePage, James P.

    2010-01-01

    With the high number of homeless, there is a critical need for rapid and accurate assessment of quality of life to assess program outcomes. The World Health Organization's WHOQOL-100 has demonstrated promise in accurately assessing quality-of-life in this population. However, its length may make large scale use impractical for working with a…

  17. Reliability and Validity of the World Health Organization Quality of Life: Brief Version (WHOQOL-BREF) in a Homeless Substance Dependent Veteran Population

    ERIC Educational Resources Information Center

    Garcia-Rea, Elizabeth A.; LePage, James P.

    2010-01-01

    With the high number of homeless, there is a critical need for rapid and accurate assessment of quality of life to assess program outcomes. The World Health Organization's WHOQOL-100 has demonstrated promise in accurately assessing quality-of-life in this population. However, its length may make large scale use impractical for working with a…

  18. Crystallization force--a density functional theory concept for revealing intermolecular interactions and molecular packing in organic crystals.

    PubMed

    Li, Tonglei; Ayers, Paul W; Liu, Shubin; Swadley, Matthew J; Aubrey-Medendorp, Clare

    2009-01-01

    Organic molecules are prone to polymorphic formation in the solid state due to the rich diversity of functional groups that results in comparable intermolecular interactions, which can be greatly affected by the selection of solvent and other crystallization conditions. Intermolecular interactions are typically weak forces, such as van der Waals and stronger short-range ones including hydrogen bonding, that are believed to determine the packing of organic molecules during the crystal-growth process. A different packing of the same molecules leads to the formation of a new crystal structure. To disclose the underlying causes that drive the molecule to have various packing motifs in the solid state, an electronic concept or function within the framework of conceptual density functional theory has been developed, namely, crystallization force. The concept aims to describe the local change in electronic structure as a result of the self-assembly process of crystallization and may likely quantify the locality of intermolecular interactions that directs the molecular packing in a crystal. To assess the applicability of the concept, 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile, so-called ROY, which is known to have the largest number of solved polymorphs, has been examined. Electronic calculations were conducted on the seven available crystal structures as well as on the single molecule. The electronic structures were analyzed and crystallization force values were obtained. The results indicate that the crystallization forces are able to reveal intermolecular interactions in the crystals, in particular, the close contacts that are formed between molecules. Strong correlations exist between the total crystallization force and lattice energy of a crystal structure, further suggesting the underlying connection between the crystallization force and molecular packing.

  19. Reliability of Scores on the Summative Performance Assessments

    ERIC Educational Resources Information Center

    Yang, Yanyun; Oosterhof, Albert; Xia, Yan

    2015-01-01

    The authors address the reliability of scores obtained on the summative performance assessments during the pilot year of our research. Contrary to classical test theory, we discussed the advantages of using generalizability theory for estimating reliability of scores for summative performance assessments. Generalizability theory was used as the…

  20. Well-organized raspberry-like Ag@Cu bimetal nanoparticles for highly reliable and reproducible surface-enhanced Raman scattering

    NASA Astrophysics Data System (ADS)

    Lee, Jung-Pil; Chen, Dongchang; Li, Xiaxi; Yoo, Seungmin; Bottomley, Lawrence A.; El-Sayed, Mostafa A.; Park, Soojin; Liu, Meilin

    2013-11-01

    Surface-enhanced Raman scattering (SERS) is ideally suited for probing and mapping surface species and incipient phases on fuel cell electrodes because of its high sensitivity and surface-selectivity, potentially offering insights into the mechanisms of chemical and energy transformation processes. In particular, bimetal nanostructures of coinage metals (Au, Ag, and Cu) have attracted much attention as SERS-active agents due to their distinctive electromagnetic field enhancements originated from surface plasmon resonance. Here we report excellent SERS-active, raspberry-like nanostructures composed of a silver (Ag) nanoparticle core decorated with smaller copper (Cu) nanoparticles, which displayed enhanced and broadened UV-Vis absorption spectra. These unique Ag@Cu raspberry nanostructures enable us to use blue, green, and red light as the excitation laser source for surface-enhanced Raman spectroscopy (SERS) with a large enhancement factor (EF). A highly reliable SERS effect was demonstrated using Rhodamine 6G (R6G) molecules and a thin film of gadolinium doped ceria.Surface-enhanced Raman scattering (SERS) is ideally suited for probing and mapping surface species and incipient phases on fuel cell electrodes because of its high sensitivity and surface-selectivity, potentially offering insights into the mechanisms of chemical and energy transformation processes. In particular, bimetal nanostructures of coinage metals (Au, Ag, and Cu) have attracted much attention as SERS-active agents due to their distinctive electromagnetic field enhancements originated from surface plasmon resonance. Here we report excellent SERS-active, raspberry-like nanostructures composed of a silver (Ag) nanoparticle core decorated with smaller copper (Cu) nanoparticles, which displayed enhanced and broadened UV-Vis absorption spectra. These unique Ag@Cu raspberry nanostructures enable us to use blue, green, and red light as the excitation laser source for surface-enhanced Raman spectroscopy

  1. The Trofobiose Theory and organic agriculture: the active mobilization of nutrients and the use of rock powder as a tool for sustainability.

    PubMed

    Polito, Wagner L

    2006-12-01

    The primary objective of the present paper is to link some relevant concepts on the use of ecological agricultural practices to the production of food crops. In a special topic the Trofobiose Theory, as well as the principle of Active Dissolution of Rocks are considered as important tools in improving the sustainability of Organic, Biodynamic and Process Agricultures.

  2. Luminescent properties of metal-organic framework MOF-5: relativistic time-dependent density functional theory investigations.

    PubMed

    Ji, Min; Lan, Xin; Han, Zhenping; Hao, Ce; Qiu, Jieshan

    2012-11-19

    The electronically excited state and luminescence property of metal-organic framework MOF-5 were investigated using relativistic density functional theory (DFT) and time-dependent DFT (TDDFT). The geometry, IR spectra, and UV-vis spectra of MOF-5 in the ground state were calculated using relativistic DFT, leading to good agreement between the experimental and theoretical results. The frontier molecular orbitals and electronic configuration indicated that the luminescence mechanism in MOF-5 follows ligand-to-ligand charge transfer (LLCT), namely, π* → π, rather than emission with the ZnO quantum dot (QD) proposed by Bordiga et al. The geometry and IR spectra of MOF-5 in the electronically excited state have been calculated using the relativistic TDDFT and compared with those for the ground state. The comparison reveals that the Zn4O13 QD is rigid, whereas the ligands BDC(2-) are nonrigid. In addition, the calculated emission band of MOF-5 is in good agreement with the experimental result and is similar to that of the ligand H2BDC. The combined results confirmed that the luminescence mechanism for MOF-5 should be LLCT with little mixing of the ligand-to-metal charge transfer. The reason for the MOF-5 luminescence is explained by the excellent coplanarity between the six-membered ring consisting of zinc, oxygen, carbon, and the benzene ring.

  3. Self-organized criticality as Witten-type topological field theory with spontaneously broken Becchi-Rouet-Stora-Tyutin symmetry

    SciTech Connect

    Ovchinnikov, Igor V.

    2011-05-15

    Here, a scenario is proposed, according to which a generic self-organized critical (SOC) system can be looked upon as a Witten-type topological field theory (W-TFT) with spontaneously broken Becchi-Rouet-Stora-Tyutin (BRST) symmetry. One of the conditions for the SOC is the slow driving noise, which unambiguously suggests Stratonovich interpretation of the corresponding stochastic differential equation (SDE). This, in turn, necessitates the use of Parisi-Sourlas-Wu stochastic quantization procedure, which straightforwardly leads to a model with BRST-exact action, i.e., to a W-TFT. In the parameter space of the SDE, there must exist full-dimensional regions where the BRST symmetry is spontaneously broken by instantons, which in the context of SOC are essentially avalanches. In these regions, the avalanche-type SOC dynamics is liberated from overwise a rightful dynamics-less W-TFT, and a Goldstone mode of Fadeev-Popov ghosts exists. Goldstinos represent moduli of instantons (avalanches) and being gapless are responsible for the critical avalanche distribution in the low-energy, long-wavelength limit. The above arguments are robust against moderate variations of the SDE's parameters and the criticality is 'self-tuned'. The proposition of this paper suggests that the machinery of W-TFTs may find its applications in many different areas of modern science studying various physical realizations of SOC. It also suggests that there may in principle exist a connection between some SOC's and the concept of topological quantum computing.

  4. Workplace support, discrimination, and person-organization fit: tests of the theory of work adjustment with LGB individuals.

    PubMed

    Velez, Brandon L; Moradi, Bonnie

    2012-07-01

    The present study explored the links of 2 workplace contextual variables--perceptions of workplace heterosexist discrimination and lesbian, gay, and bisexual (LGB)-supportive climates--with job satisfaction and turnover intentions in a sample of LGB employees. An extension of the theory of work adjustment (TWA) was used as the conceptual framework for the study; as such, perceived person-organization (P-O) fit was tested as a mediator of the relations between the workplace contextual variables and job outcomes. Data were analyzed from 326 LGB employees. Zero-order correlations indicated that perceptions of workplace heterosexist discrimination and LGB-supportive climates were correlated in expected directions with P-O fit, job satisfaction, and turnover intentions. Structural equation modeling (SEM) was used to compare multiple alternative measurement models evaluating the discriminant validity of the 2 workplace contextual variables relative to one another, and the 3 TWA job variables relative to one another; SEM was also used to test the hypothesized mediation model. Comparisons of multiple alternative measurement models supported the construct distinctiveness of the variables of interest. The test of the hypothesized structural model revealed that only LGB-supportive climates (and not workplace heterosexist discrimination) had a unique direct positive link with P-O fit and, through the mediating role of P-O fit, had significant indirect positive and negative relations with job satisfaction and turnover intentions, respectively. Moreover, P-O fit had a significant indirect negative link with turnover intentions through job satisfaction.

  5. [Ambulatory, interdisciplinary team work in the tension field between theory and practice--Vorarlberg social medicine organization].

    PubMed

    Girardi, P; Acherer, E; Holzapfl, M; Strebl, L

    1998-11-01

    Presented is the Social-Medical Organization active in the field of ambulatory neurological care of adults in Vorarlberg, Austria, offering interdisciplinary cooperation possibilities in terms of team consultation, case presentation and discussion, as well as supervision. Ambulatory interdisciplinary teamwork is situated in a theory-practice field of tension, with occupational training failing to teach interdisciplinary cooperation and interdisciplinarity role models not encountered either during practicals. The ensuing, deliberately identified problems and issues have been addressed in a planned process. Familiarization with the various occupational fields involved, with each field having its specific job profile, as well as the notions on cooperation among the various fields are presented. The role the various occupational fields have in neurological aftercare as well as existing job profile clichés are reflected upon. Communication is in addition hampered by the diversity of training contents in the various occupational fields. Focussing on case presentation and discussion, teams are considered a place for obtaining advice, for joint development of targets and strategies, and interdisciplinary interfacing is no longer perceived as threatening but as enriching and productive. The role of stronger family doctor inclusion in formulation therapy goals remains an issue as yet unsolved.

  6. The effects of instructors' autonomy support and students' autonomous motivation on learning organic chemistry: A self-determination theory perspective

    NASA Astrophysics Data System (ADS)

    Black, Aaron E.; Deci, Edward L.

    2000-11-01

    This prospective study applied self-determination theory to investigate the effects of students' course-specific self-regulation and their perceptions of their instructors' autonomy support on adjustment and academic performance in a college-level organic chemistry course. The study revealed that: (1) students' reports of entering the course for relatively autonomous (vs. controlled) reasons predicted higher perceived competence and interest/enjoyment and lower anxiety and grade-focused performance goals during the course, and were related to whether or not the students dropped the course; and (2) students' perceptions of their instructors' autonomy support predicted increases in autonomous self-regulation, perceived competence, and interest/enjoyment, and decreases in anxiety over the semester. The change in autonomous self-regulation in turn predicted students' performance in the course. Further, instructor autonomy support also predicted course performance directly, although differences in the initial level of students' autonomous self-regulation moderated that effect, with autonomy support relating strongly to academic performance for students initially low in autonomous self-regulation but not for students initially high in autonomous self-regulation.

  7. Phosphorescence lifetimes of organic light-emitting diodes from two-component time-dependent density functional theory

    SciTech Connect

    Kühn, Michael; Weigend, Florian

    2014-12-14

    “Spin-forbidden” transitions are calculated for an eight-membered set of iridium-containing candidate molecules for organic light-emitting diodes (OLEDs) using two-component time-dependent density functional theory. Phosphorescence lifetimes (obtained from averaging over relevant excitations) are compared to experimental data. Assessment of parameters like non-distorted and distorted geometric structures, density functionals, relativistic Hamiltonians, and basis sets was done by a thorough study for Ir(ppy){sub 3} focussing not only on averaged phosphorescence lifetimes, but also on the agreement of the triplet substate structure with experimental data. The most favorable methods were applied to an eight-membered test set of OLED candidate molecules; Boltzmann-averaged phosphorescence lifetimes were investigated concerning the convergence with the number of excited states and the changes when including solvent effects. Finally, a simple model for sorting out molecules with long averaged phosphorescence lifetimes is developed by visual inspection of computationally easily achievable one-component frontier orbitals.

  8. Analysis of algal bloom risk with uncertainties in lakes by integrating self-organizing map and fuzzy information theory.

    PubMed

    Chen, Qiuwen; Rui, Han; Li, Weifeng; Zhang, Yanhui

    2014-06-01

    Algal blooms are a serious problem in waters, which damage aquatic ecosystems and threaten drinking water safety. However, the outbreak mechanism of algal blooms is very complex with great uncertainty, especially for large water bodies where environmental conditions have obvious variation in both space and time. This study developed an innovative method which integrated a self-organizing map (SOM) and fuzzy information diffusion theory to comprehensively analyze algal bloom risks with uncertainties. The Lake Taihu was taken as study case and the long-term (2004-2010) on-site monitoring data were used. The results showed that algal blooms in Taihu Lake were classified into four categories and exhibited obvious spatial-temporal patterns. The lake was mainly characterized by moderate bloom but had high uncertainty, whereas severe blooms with low uncertainty were observed in the northwest part of the lake. The study gives insight on the spatial-temporal dynamics of algal blooms, and should help government and decision-makers outline policies and practices on bloom monitoring and prevention. The developed method provides a promising approach to estimate algal bloom risks under uncertainties. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Well-organized raspberry-like Ag@Cu bimetal nanoparticles for highly reliable and reproducible surface-enhanced Raman scattering.

    PubMed

    Lee, Jung-Pil; Chen, Dongchang; Li, Xiaxi; Yoo, Seungmin; Bottomley, Lawrence A; El-Sayed, Mostafa A; Park, Soojin; Liu, Meilin

    2013-12-07

    Surface-enhanced Raman scattering (SERS) is ideally suited for probing and mapping surface species and incipient phases on fuel cell electrodes because of its high sensitivity and surface-selectivity, potentially offering insights into the mechanisms of chemical and energy transformation processes. In particular, bimetal nanostructures of coinage metals (Au, Ag, and Cu) have attracted much attention as SERS-active agents due to their distinctive electromagnetic field enhancements originated from surface plasmon resonance. Here we report excellent SERS-active, raspberry-like nanostructures composed of a silver (Ag) nanoparticle core decorated with smaller copper (Cu) nanoparticles, which displayed enhanced and broadened UV-Vis absorption spectra. These unique Ag@Cu raspberry nanostructures enable us to use blue, green, and red light as the excitation laser source for surface-enhanced Raman spectroscopy (SERS) with a large enhancement factor (EF). A highly reliable SERS effect was demonstrated using Rhodamine 6G (R6G) molecules and a thin film of gadolinium doped ceria.

  10. Reliability and Expected Loss: A Unifying Principle.

    ERIC Educational Resources Information Center

    Cooil, Bruce; Rust, Roland T.

    1994-01-01

    It is proposed that proportional reduction in loss (PRL) be used as a theoretical basis to derive, justify, and interpret reliability measures to gauge reliability on a zero-to-one scale. This PRL approach simplifies the interpretation of existing measures (e.g., generalizability-theory measures). (SLD)

  11. An Introduction to Structural Reliability Theory

    DTIC Science & Technology

    1989-01-01

    the following result: (k sm - asma *snp) (USf -’tf- c*fy 3) (,sw- (swc*sw)-( Lw-GwC*wP3) = 0 (5.47) Equation (5.47) is to be solved for 3. Notice that...straight line on a semi-log plot (Figure 9.1), and c = 2 results in the Rayleigh distribution. Guidelines for c for platforms in the Gulf of Mexico are...coo <z -M w ww zz IVw w 0 0)ulI 0 43 0 c ’si 3:ViS$&1 < 4aNa 235 DEPENDS ON SHOALINGDEPENDS ON 1.0 (SHELF PROFILE) NAT. PERIOD GULF OF MEXICO 0 - - I

  12. Reliability beyond Theory and into Practice

    ERIC Educational Resources Information Center

    Sijtsma, Klaas

    2009-01-01

    The critical reactions of Bentler (2009, doi: 10.1007/s11336-008-9100-1), Green and Yang (2009a, doi: 10.1007/s11336-008-9098-4 ; 2009b, doi: 10.1007/s11336-008-9099-3), and Revelle and Zinbarg (2009, doi: 10.1007/s11336-008-9102-z) to Sijtsma's (2009, doi: 10.1007/s11336-008-9101-0) paper on Cronbach's alpha are addressed. The dissemination of…

  13. Conference on Operator Theory, Wavelet Theory and Control Theory

    DTIC Science & Technology

    1993-09-30

    Bourbaki 662 (1985-1986). [9] Meyer, Y., Ondelettes et operateurs I, Hermann editeurs des sciences et des arts, 1990. [10] Natanson, I. P., Theory of...OPERATOR THEORY , WAVELET THEORY & CONTROL THEORY (U)F 6. AUTHOR(S) 2304/ES Professor Xingde Dai F49620-93-1-0180 7. PERFORMING ORGANIZATION NAME(S) AND...1STRIBUTION IS UNLIMITED UTL 13. ABSTRACT (Maximum 200 words) The conference on Interaction Between Operator Theory , Wavelet Theory and Control Theory

  14. Reliability model generator

    NASA Technical Reports Server (NTRS)

    McMann, Catherine M. (Inventor); Cohen, Gerald C. (Inventor)

    1991-01-01

    An improved method and system for automatically generating reliability models for use with a reliability evaluation tool is described. The reliability model generator of the present invention includes means for storing a plurality of low level reliability models which represent the reliability characteristics for low level system components. In addition, the present invention includes means for defining the interconnection of the low level reliability models via a system architecture description. In accordance with the principles of the present invention, a reliability model for the entire system is automatically generated by aggregating the low level reliability models based on the system architecture description.

  15. Application of the IAS theory combining to a three compartments description of natural organic matter to the adsorption of atrazine or diuron on activated carbon.

    PubMed

    Baudu, M; Raveau, D; Guibaud, G

    2004-07-01

    The study of natural organic matter (NOM) adsorption on an activated carbon showed that equilibrium cannot be described according to a simple model such as a Freundlich isotherm and confirms the need for a closer description of the organic matter to simulate the competitive adsorption with micropollutants. A representation of the organic matter in three fractions is chosen: non-adsorbable, weak and strong adsorbable. The Ideal Adsorbed Solution Theory (IAST) can, under restrictive conditions, be used to effectively predict the competition between the pesticides and the organic matter. Therefore, it was noted that the model simulated with good precision the competition between atrazine or diuron and natural organic matter in aqueous solution for two activated carbons (A and B). The same parameters for the modeling of organic matter adsorption (Freudlich constants for two absorbable fractions) are used with the two pesticides. However, IAST does not allow correct modeling of pesticide adsorption onto two other (C and D) activated carbons in solution in natural water to be described. IAS theory does not reveal competition between diuron and NOM and pore blockage mechanism by the NOM is proposed as the major effect for the adsorption capacity reduction. However, the difference observed between the two pesticides could be due to in addition to the pore blockage effect, a particular phenomenon with the diuron, especially with D activated carbon. We can suppose specific interactions between the diuron and the adsorbed organic matter and a competition between adsorption sites of NOM and activated carbon surface.

  16. Organization-wide adoption of computerized provider order entry systems: a study based on diffusion of innovations theory.

    PubMed

    Rahimi, Bahlol; Timpka, Toomas; Vimarlund, Vivian; Uppugunduri, Srinivas; Svensson, Mikael

    2009-12-31

    Computerized provider order entry (CPOE) systems have been introduced to reduce medication errors, increase safety, improve work-flow efficiency, and increase medical service quality at the moment of prescription. Making the impact of CPOE systems more observable may facilitate their adoption by users. We set out to examine factors associated with the adoption of a CPOE system for inter-organizational and intra-organizational care. The diffusion of innovation theory was used to understand physicians' and nurses' attitudes and thoughts about implementation and use of the CPOE system. Two online survey questionnaires were distributed to all physicians and nurses using a CPOE system in county-wide healthcare organizations. The number of complete questionnaires analyzed was 134 from 200 nurses (67.0%) and 176 from 741 physicians (23.8%). Data were analyzed using descriptive-analytical statistical methods. More nurses (56.7%) than physicians (31.3%) stated that the CPOE system introduction had worked well in their clinical setting (P < 0.001). Similarly, more physicians (73.9%) than nurses (50.7%) reported that they found the system not adapted to their specific professional practice (P = < 0.001). Also more physicians (25.0%) than nurses (13.4%) stated that they did want to return to the previous system (P = 0.041). We found that in particular the received relative advantages of the CPOE system were estimated to be significantly (P < 0.001) higher among nurses (39.6%) than physicians (16.5%). However, physicians' agreements with the compatibility of the CPOE and with its complexity were significantly higher than the nurses (P < 0.001). Qualifications for CPOE adoption as defined by three attributes of diffusion of innovation theory were not satisfied in the study setting. CPOE systems are introduced as a response to the present limitations in paper-based systems. In consequence, user expectations are often high on their relative advantages as well as on a low level of

  17. Force Field Development from Periodic Density Functional Theory Calculations for Gas Separation Applications Using Metal–Organic Frameworks

    DOE PAGES

    Mercado, Rocio; Vlaisavljevich, Bess; Lin, Li -Chiang; ...

    2016-05-25

    We present accurate force fields developed from density functional theory (DFT) calculations with periodic boundary conditions for use in molecular simulations involving M2(dobdc) (M-MOF-74; dobdc4– = 2,5-dioxidobenzenedicarboxylate; M = Mg, Mn, Fe, Co, Ni, Zn) and frameworks of similar topology. In these systems, conventional force fields fail to accurately model gas adsorption due to the strongly binding open-metal sites. The DFT-derived force fields predict the adsorption of CO2, H2O, and CH4 inside these frameworks much more accurately than other common force fields. We show that these force fields can also be used for M2(dobpdc) (dobpdc4– = 4,4'-dioxidobiphenyl-3,3'-dicarboxylate), an extended versionmore » of MOF-74, and thus are a promising alternative to common force fields for studying materials similar to MOF-74 for carbon capture applications. Furthermore, it is anticipated that the approach can be applied to other metal–organic framework topologies to obtain force fields for different systems. We have used this force field to study the effect of contaminants such as H2O and N2 upon these materials’ performance for the separation of CO2 from the emissions of natural gas reservoirs and coal-fired power plants. Specifically, mixture adsorption isotherms calculated with these DFT-derived force fields showed a significant reduction in the uptake of many gas components in the presence of even trace amounts of H2O vapor. The extent to which the various gases are affected by the concentration of H2O in the reservoir is quantitatively different for the different frameworks and is related to their heats of adsorption. Additionally, significant increases in CO2 selectivities over CH4 and N2 are observed as the temperature of the systems is lowered.« less

  18. Cognitive decision errors and organization vulnerabilities in nuclear power plant safety management: Modeling using the TOGA meta-theory framework

    SciTech Connect

    Cappelli, M.; Gadomski, A. M.; Sepiellis, M.; Wronikowska, M. W.

    2012-07-01

    In the field of nuclear power plant (NPP) safety modeling, the perception of the role of socio-cognitive engineering (SCE) is continuously increasing. Today, the focus is especially on the identification of human and organization decisional errors caused by operators and managers under high-risk conditions, as evident by analyzing reports on nuclear incidents occurred in the past. At present, the engineering and social safety requirements need to enlarge their domain of interest in such a way to include all possible losses generating events that could be the consequences of an abnormal state of a NPP. Socio-cognitive modeling of Integrated Nuclear Safety Management (INSM) using the TOGA meta-theory has been discussed during the ICCAP 2011 Conference. In this paper, more detailed aspects of the cognitive decision-making and its possible human errors and organizational vulnerability are presented. The formal TOGA-based network model for cognitive decision-making enables to indicate and analyze nodes and arcs in which plant operators and managers errors may appear. The TOGA's multi-level IPK (Information, Preferences, Knowledge) model of abstract intelligent agents (AIAs) is applied. In the NPP context, super-safety approach is also discussed, by taking under consideration unexpected events and managing them from a systemic perspective. As the nature of human errors depends on the specific properties of the decision-maker and the decisional context of operation, a classification of decision-making using IPK is suggested. Several types of initial situations of decision-making useful for the diagnosis of NPP operators and managers errors are considered. The developed models can be used as a basis for applications to NPP educational or engineering simulators to be used for training the NPP executive staff. (authors)

  19. Effects of London dispersion correction in density functional theory on the structures of organic molecules in the gas phase.

    PubMed

    Grimme, Stefan; Steinmetz, Marc

    2013-10-14

    A benchmark set of 25 rotational constants measured in the gas phase for nine molecules (termed ROT25) was compiled from available experimental data. The medium-sized molecules with 18-35 atoms cover common (bio)organic structure motifs including hydrogen bonding and flexible side chains. They were each considered in a single conformation. The experimental B0 values were back-corrected to reference equilibrium rotational constants (Be) by computation of the vibrational corrections ΔBvib. Various density functional theory (DFT) methods and Hartree-Fock with and without dispersion corrections as well as MP2 type methods and semi-empirical quantum chemical approaches are investigated. The ROT25 benchmark tests their ability to describe covalent bond lengths, longer inter-atomic distances, and the relative orientation of functional groups (intramolecular non-covalent interactions). In general, dispersion corrections to DFT and HF increase Be values (shrink molecular size) significantly by about 0.5-1.5% thereby in general improving agreement with the reference data. Regarding DFT methods, the overall accuracy of the optimized structures roughly follows the 'Jacobs ladder' classification scheme, i.e., it decreases in the series double-hybrid > (meta)hybrid > (meta)GGA > LDA. With B2PLYP-D3, SCS-MP2, B3LYP-D3/NL, or PW6B95-D3 methods and extended QZVP (def2-TZVP) AO basis sets, Be values, accurate to about 0.3-0.6 (0.5-1)% on average, can be computed routinely. The accuracy of B2PLYP-D3/QZVP with a mean deviation of only 3 MHz and a standard deviation of 0.24% is exceptional and we recommend this method when highly accurate structures are required or for problematic conformer assignments. The correlation effects for three inter-atomic distance regimes (covalent, medium-range, long) and the performance of minimal basis set (semi-empirical) methods are discussed.

  20. Reliability Generalization: "Lapsus Linguae"

    ERIC Educational Resources Information Center

    Smith, Julie M.

    2011-01-01

    This study examines the proposed Reliability Generalization (RG) method for studying reliability. RG employs the application of meta-analytic techniques similar to those used in validity generalization studies to examine reliability coefficients. This study explains why RG does not provide a proper research method for the study of reliability,…