Apparatus for growing a dendritic web

DOEpatents

Duncan, Charles S.; Piotrowski, Paul A.; Skutch, Maria E.; McHugh, James P.

1983-06-21

A melt system including a susceptor-crucible assembly having improved gradient control when melt replenishment is used during dendritic web growth. The improvement lies in the formation of a thermal barrier in the base of the receptor which is in the form of a vertical slot in the region of the susceptor underlying the crucible at the location of a compartmental separator dividing the crucible into a growth compartment and a melt replenishment compartment. The result achieved is a step change in temperature gradient in the melt thereby providing a more uniform temperature in the growth compartment from which the dendritic web is drawn.

Optimal pricing and replenishment policies for instantaneous deteriorating items with backlogging and trade credit under inflation

NASA Astrophysics Data System (ADS)

Sundara Rajan, R.; Uthayakumar, R.

2017-12-01

In this paper we develop an economic order quantity model to investigate the optimal replenishment policies for instantaneous deteriorating items under inflation and trade credit. Demand rate is a linear function of selling price and decreases negative exponentially with time over a finite planning horizon. Shortages are allowed and partially backlogged. Under these conditions, we model the retailer's inventory system as a profit maximization problem to determine the optimal selling price, optimal order quantity and optimal replenishment time. An easy-to-use algorithm is developed to determine the optimal replenishment policies for the retailer. We also provide optimal present value of profit when shortages are completely backlogged as a special case. Numerical examples are presented to illustrate the algorithm provided to obtain optimal profit. And we also obtain managerial implications from numerical examples to substantiate our model. The results show that there is an improvement in total profit from complete backlogging rather than the items being partially backlogged.

Calcium regulates vesicle replenishment at the cone ribbon synapse

PubMed Central

Babai, Norbert; Bartoletti, Theodore M.; Thoreson, Wallace B.

2010-01-01

Cones release glutamate-filled vesicles continuously in darkness and changing illumination modulates this release. Because sustained release in darkness is governed by vesicle replenishment rates, we analyzed how cone membrane potential regulates replenishment. Synaptic release from cones was measured by recording post-synaptic currents in Ambystoma tigrinum horizontal or OFF bipolar cells evoked by depolarization of simultaneously voltage-clamped cones. We measured replenishment after attaining a steady-state between vesicle release and replenishment using trains of test pulses. Increasing Ca2+ currents (ICa) by changing the test step from −30 to −10 mV increased replenishment. Lengthening −30 mV test pulses to match the Ca2+ influx during 25 ms test pulses to −10 mV produced similar replenishment rates. Reducing Ca2+ driving force by using test steps to +30 mV slowed replenishment. Using UV flashes to reverse inhibition of ICa by nifedipine accelerated replenishment. Increasing [Ca2+]i by flash photolysis of caged Ca2+ also accelerated replenishment. Replenishment, but not the initial burst of release, was enhanced by using an intracellular Ca2+ buffer of 0.5 mM EGTA rather than 5 mM EGTA, and diminished by 1 mM BAPTA. This suggests that although release and replenishment and release exhibited similar Ca2+-dependencies, release sites are <200 nm from Ca2+ channels but replenishment sites are >200 nm away. Membrane potential thus regulates replenishment by controlling Ca2+ influx, principally by effects on replenishment mechanisms but also by altering releasable pool size. This in turn provides a mechanism for converting changes in light intensity into changes in sustained release at the cone ribbon synapse. PMID:21106825

Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors

PubMed Central

Parmelee, Caitlyn M.; Chen, Minghui; Cork, Karlene M.; Curto, Carina; Thoreson, Wallace B.

2014-01-01

At the first synapse in the vertebrate visual pathway, light-evoked changes in photoreceptor membrane potential alter the rate of glutamate release onto second-order retinal neurons. This process depends on the synaptic ribbon, a specialized structure found at various sensory synapses, to provide a supply of primed vesicles for release. Calcium (Ca2+) accelerates the replenishment of vesicles at cone ribbon synapses, but the mechanisms underlying this acceleration and its functional implications for vision are unknown. We studied vesicle replenishment using paired whole-cell recordings of cones and postsynaptic neurons in tiger salamander retinas and found that it involves two kinetic mechanisms, the faster of which was diminished by calmodulin (CaM) inhibitors. We developed an analytical model that can be applied to both conventional and ribbon synapses and showed that vesicle resupply is limited by a simple time constant, τ = 1/(Dρδs), where D is the vesicle diffusion coefficient, δ is the vesicle diameter, ρ is the vesicle density, and s is the probability of vesicle attachment. The combination of electrophysiological measurements, modeling, and total internal reflection fluorescence microscopy of single synaptic vesicles suggested that CaM speeds replenishment by enhancing vesicle attachment to the ribbon. Using electroretinogram and whole-cell recordings of light responses, we found that enhanced replenishment improves the ability of cone synapses to signal darkness after brief flashes of light and enhances the amplitude of responses to higher-frequency stimuli. By accelerating the resupply of vesicles to the ribbon, CaM extends the temporal range of synaptic transmission, allowing cones to transmit higher-frequency visual information to downstream neurons. Thus, the ability of the visual system to encode time-varying stimuli is shaped by the dynamics of vesicle replenishment at photoreceptor synaptic ribbons. PMID:25311636

Photocathode device that replenishes photoemissive coating

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moody, Nathan A.; Lizon, David C.

2016-06-14

A photocathode device may replenish its photoemissive coating to replace coating material that desorbs/evaporates during photoemission. A linear actuator system may regulate the release of a replenishment material vapor, such as an alkali metal, from a chamber inside the photocathode device to a porous cathode substrate. The replenishment material deposits on the inner surface of a porous membrane and effuses through the membrane to the outer surface, where it replenishes the photoemissive coating. The rate of replenishment of the photoemissive coating may be adjusted using the linear actuator system to regulate performance of the photocathode device during photoemission. Alternatively, themore » linear actuator system may adjust a plasma discharge gap between a cartridge containing replenishment material and a metal grid. A potential is applied between the cartridge and the grid, resulting in ejection of metal ions from the cartridge that similarly replenish the photoemissive coating.« less

Effects of beach replenishment on intertidal invertebrates: A 15-month, eight beach study.

NASA Astrophysics Data System (ADS)

Wooldridge, Tyler; Henter, Heather J.; Kohn, Joshua R.

2016-06-01

Beach replenishment is an increasingly popular means to remediate coastal erosion, but no consensus exists regarding how long replenishment affects sandy beach intertidal invertebrates, key components of beach ecosystems. We monitored the intertidal invertebrate community for fifteen months following a replenishment project at eight beaches, each with replenished and control sections, across San Diego County. Nearly all taxa showed major declines in abundance immediately following replenishment. Populations of talitrid amphipods and the bean clam Donax gouldii recovered within one year, sooner than in previous studies. On some beaches, populations of the mole crab Emerita analoga bloomed four months after replenishment and were more numerous on replenished portions of beaches at that time. Mole crab populations subsequently declined and no longer differed by treatment. The polychaete community, composed of Scolelepis sp. and several other numerically important taxa, showed a strong replenishment-induced reduction in abundance that persisted through the end of the study. The large negative effect of replenishment on polychaetes, coupled with their overall importance to the invertebrate community, resulted in a more than twofold reduction in overall invertebrate abundance on replenished beaches at 15 months. Such reductions may have far reaching consequences for sandy beach ecosystems, as community declines can reduce prey availability for shorebirds and fish. As this and other recent studies have revealed longer times for the recovery of intertidal invertebrates than previously observed, longer study periods and more cautious estimates regarding the magnitude, variability, and duration of impacts of beach replenishment for management decision-making are warranted.

Accelerating Genetic Gains in Legumes for the Development of Prosperous Smallholder Agriculture: Integrating Genomics, Phenotyping, Systems Modelling and Agronomy.

PubMed

Varshney, Rajeev K; Thudi, Mahendar; Pandey, Manish K; Tardieu, Francois; Ojiewo, Chris; Vadez, Vincent; Whitbread, Anthony M; Siddique, Kadambot H M; Nguyen, Henry T; Carberry, Peter S; Bergvinson, David

2018-03-05

Grain legumes form an important component of the human diet, feed for livestock and replenish soil fertility through biological nitrogen fixation. Globally, the demand for food legumes is increasing as they complement cereals in protein requirements and possess a high percentage of digestible protein. Climate change has enhanced the frequency and intensity of drought stress that is posing serious production constraints, especially in rainfed regions where most legumes are produced. Genetic improvement of legumes, like other crops, is mostly based on pedigree and performance-based selection over the last half century. For achieving faster genetic gains in legumes in rainfed conditions, this review article proposes the integration of modern genomics approaches, high throughput phenomics and simulation modelling as support for crop improvement that leads to improved varieties that perform with appropriate agronomy. Selection intensity, generation interval and improved operational efficiencies in breeding are expected to further enhance the genetic gain in experiment plots. Improved seed access to farmers, combined with appropriate agronomic packages in farmers' fields, will deliver higher genetic gains. Enhanced genetic gains including not only productivity but also nutritional and market traits will increase the profitability of farmers and the availability of affordable nutritious food especially in developing countries.

Modelling of a Convecting, Crystallizing, and Replenished Diopside-Anorthite Axial Magma Chamber beneath Mid Ocean Ridges

NASA Astrophysics Data System (ADS)

Lowell, R. P.; Lata, C.

2016-12-01

The aim of this work is to model heat output from a cooling, convective, crystallizing, and replenished basaltic magma sill, representing an axial magma lens (AML) at mid oceanic ridges. As a simplified version of basaltic melt, we have assumed the melt to be a two-component eutectic system composed of diopside and anorthite. Convective vigor is expressed through the Rayleigh number and heat flux is scaled through a classical relationship between the Rayleigh number and Nusselt number, where the temperature difference driving the convective heat flux is derived from a "viscous" temperature scale reflecting the strong temperature dependent viscosity of the system. Viscosity is modeled as a function of melt composition and temperature using the Tammann-Vogel-Fulcher equation, with parameters fit to the values of observed viscosities along the diopside-anorthite liquidus. It was observed for the un-replenished case, in which crystals fall rapidly to the floor of the AML, model results show that the higher initial concentration of diopside, the more vigorous the convection and the faster the rate of crystallization and decay of heat output. Replenishment of the AML accompanied by modest thickening of the melt layer stabilizes the heat output at values similar to those observed at ridge-axis hydrothermal systems. This study is an important step forward in quantitative understanding of thermal evolution of the axial magma lens at a mid-ocean ridge and the corresponding effect on high-temperature hydrothermal systems. Future work could involve improved replenishment mechanisms, more complex melts, and direct coupling with hydrothermal circulation models.

32 CFR 707.5 - Underway replenishment contour lights.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Underway replenishment contour lights. 707.5... RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.5 Underway replenishment contour lights... underway replenishment operations, either red or blue lights at delivery-ship-deck-edge extremities. [42 FR...

32 CFR 707.5 - Underway replenishment contour lights.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 5 2014-07-01 2014-07-01 false Underway replenishment contour lights. 707.5... RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.5 Underway replenishment contour lights... underway replenishment operations, either red or blue lights at delivery-ship-deck-edge extremities. [42 FR...

32 CFR 707.5 - Underway replenishment contour lights.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Underway replenishment contour lights. 707.5... RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.5 Underway replenishment contour lights... underway replenishment operations, either red or blue lights at delivery-ship-deck-edge extremities. [42 FR...

32 CFR 707.5 - Underway replenishment contour lights.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Underway replenishment contour lights. 707.5... RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.5 Underway replenishment contour lights... underway replenishment operations, either red or blue lights at delivery-ship-deck-edge extremities. [42 FR...

32 CFR 707.5 - Underway replenishment contour lights.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Underway replenishment contour lights. 707.5... RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.5 Underway replenishment contour lights... underway replenishment operations, either red or blue lights at delivery-ship-deck-edge extremities. [42 FR...

Juggling carbon: allocation patterns of a dominant tree in a fire-prone savanna.

PubMed

Schutz, Alexander Ernest Noel; Bond, William J; Cramer, Michael D

2009-05-01

In frequently burnt mesic savannas, trees can get trapped into a cycle of surviving fire-induced stem death (i.e. topkill) by resprouting, only to be topkilled again a year or two later. The ability of savanna saplings to resprout repeatedly after fire is a key component of recent models of tree-grass coexistence in savannas. This study investigated the carbon allocation and biomass partitioning patterns that enable a dominant savanna tree, Acacia karroo, to survive frequent and repeated topkill. Root starch depletion and replenishment, foliage recovery and photosynthesis of burnt and unburnt plants were compared over the first year after a burn. The concentration of starch in the roots of the burnt plants (0.08 +/- 0.01 g g(-1)) was half that of the unburnt plant (0.16 +/- 0.01 g g(-1)) at the end of the first growing season after topkill. However, root starch reserves of the burnt plants were replenished over the dry season and matched that of unburnt plants within 1 year after topkill. The leaf area of resprouting plants recovered to match that of unburnt plants within 4-5 months after topkill. Shoot growth of resprouting plants was restricted to the first few months of the wet season, whereas photosynthetic rates remained high into the dry season, allowing replenishment of root starch reserves. (14)C labeling showed that reserves were initially utilized for shoot growth after topkill. The rapid foliage recovery and the replenishment of reserves within a single year after topkill implies that A. karroo is well adapted to survive recurrent topkill and is poised to take advantage of unusually long fire-free intervals to grow into adults. This paper provides some of the first empirical evidence to explain how savanna trees in frequently burnt savannas are able to withstand frequent burning as juveniles and survive to become adults.

Constraints on the Rates of Replenishment, Magma Mixing, and Crystal Recycling at Santorini Volcano, Greece

NASA Astrophysics Data System (ADS)

Martin, V. M.; Davidson, J. P.; Morgan, D. J.; Jerram, D. A.

2007-12-01

Santorini is a young, active volcano, which preserves abundant evidence for open-system processes such as magma replenishment and crystal recycling, and thus represents an ideal system in which to study magma chamber dynamics. Santorini is the largest volcanic centre in the Aegean arc, with an eruptive history spanning more than 250,000 years over two eruptive cycles. The cycles are dominated by extended periods of effusive shield-building activity with occasional large-magnitude explosive eruptions, the Minoan eruption of ~3600 years ago being the most recent. Current activity consists of a phase of post-caldera reconstruction, focused recently on the intra-caldera Kameni islands. Microsampling to measure 87Sr/86Sr ratios of plagioclase cores indicates the presence of a complex plumbing system beneath Santorini. Large rhyodacitic deposits typically contain a mafic component, interpreted as the eruption trigger. In some cases, the mafic magma groundmass and phenocrysts are isotopically similar to their rhyodacite host; other deposits show the opposite, implying the coexistence of isotopically distinct magma batches. To add further complexity, plagioclase phenocrysts are in some cases in equilibrium with their groundmass while others show the reverse, implying modification due to crystal recycling or shallow mixing processes prior to eruption. Mafic enclaves in the recent Kameni lavas, again interpreted as the probable eruption trigger, provide some constraints on the rates of these recycling, mixing, and triggering processes. Glomerocrysts and xenocrysts of recycled gabbroic cumulate material are present in a number of Kameni enclaves. Isotopic and chemical disequilibrium between the cumulate crystals and the host indicate that these fragments are derived from pre- existing crystal mush piles pervaded by the replenishing melts as they migrated to shallow levels, creating disequilibrium between the cumulate mineral cores and the replenishing melts. 87Sr/86Sr isotope ratios of plagioclase xenocryst cores suggest crystal recycling from a pre-Minoan source is probable. Olivine xenocrysts in the enclaves possess narrow (10-30 μm) Fe-Mg diffusion profiles, due to interaction with enclave magma groundmass, which can be used to estimate the interval between entrainment and eruption. Initial modelling of diffusion profiles from more than 60 crystals suggests short timescales, from 15 to 45 days, for the combined migration-replenishment-eruption cycle at Kameni.

Preliminary Experimental Results on the Technique of Artificial River Replenishment to Mitigate Sediment Loss Downstream Dams

NASA Astrophysics Data System (ADS)

Franca, M. J.; Battisacco, E.; Schleiss, A. J.

2014-12-01

The transport of sediments by water throughout the river basins, from the steep slopes of the upstream regions to the sea level, is recognizable important to keep the natural conditions of rivers with a role on their ecology processes. Over the last decades, a reduction on the supply of sand and gravel has been observed downstream dams existing in several alpine rivers. Many studies highlight that the presence of a dam strongly modifies the river behavior in the downstream reach, in terms of morphology and hydrodynamics, with consequences on local ecology. Sediment deficit, bed armoring, river incision and bank instability are the main effects which affect negatively the aquatic habitats and the water quality. One of the proposed techniques to solve the problem of sediment deficit downstream dams, already adopted in few Japanese and German rivers although on an unsatisfactory fashion, is the artificial replenishment of these. Generally, it was verified that the erosion of the replenishments was not satisfactory and the transport rate was not enough to move the sediments to sufficient downstream distances. In order to improve and to provide an engineering answer to make this technique more applicable, a series of laboratory tests are ran as preparatory study to understand the hydrodynamics of the river flow when the replenishment technique is applied. Erodible volumes, with different lengths and submergence conditions, reproducing sediment replenishments volumes, are positioned along a channel bank. Different geometrical combinations of erodible sediment volumes are tested as well on the experimental flume. The first results of the experimental research, concerning erosion time evolution, the influence of discharge and the distance travelled by the eroded sediments, will be presented and discussed.

Assessing Farmer Innovations in Agroforestry in Eastern Zambia

ERIC Educational Resources Information Center

Katanga, R.; Kabwe, G.; Kuntashula, E.; Mafongoya, P. L.; Phiri, S.

2007-01-01

This paper describes farmer innovations on improved fallows developed by researchers to replenish soil fertility. The reasons for the innovations and how these innovations are facilitating wide adoption of improved fallows are discussed. Research designed trial results to evaluate the ecological robustness of these innovations are also analyzed in…

Leaching of TCIPP from furniture foam is rapid and substantial.

PubMed

Stubbings, William A; Harrad, Stuart

2018-02-01

A series of laboratory experiments were conducted, in which waste furniture polyurethane foam samples containing tris (1-chloro-2-propyl) phosphate (TCIPP) were contacted with a range of leaching fluids, formulated to simulate the composition of landfill leachate. Leaching was examined under a number of different scenarios, such as: dissolved humic matter concentration, pH, and temperature, as well as the effect of agitation, and waste:leaching fluid contact duration. In addition to single batch (no replenishment of leaching fluid), serial batch (draining of leachate and replenishment with fresh leaching fluid at various time intervals) experiments were conducted. Leaching of TCIPP from PUF appears to be a first order process. Concentrations of TCIPP in leachate generated by the experiments in this study ranged from 13 mg L -1 to 130 mg L -1 . In serial batch leaching experiments, >95% of TCIPP was depleted from PUF after 168 h total contact with leaching fluid. Our experiments indicate leaching is potentially a very significant pathway of TCIPP emissions to the environment. Copyright © 2017. Published by Elsevier Ltd.

A novel multi-item joint replenishment problem considering multiple type discounts.

PubMed

Cui, Ligang; Zhang, Yajun; Deng, Jie; Xu, Maozeng

2018-01-01

In business replenishment, discount offers of multi-item may either provide different discount schedules with a single discount type, or provide schedules with multiple discount types. The paper investigates the joint effects of multiple discount schemes on the decisions of multi-item joint replenishment. In this paper, a joint replenishment problem (JRP) model, considering three discount (all-unit discount, incremental discount, total volume discount) offers simultaneously, is constructed to determine the basic cycle time and joint replenishment frequencies of multi-item. To solve the proposed problem, a heuristic algorithm is proposed to find the optimal solutions and the corresponding total cost of the JRP model. Numerical experiment is performed to test the algorithm and the computational results of JRPs under different discount combinations show different significance in the replenishment cost reduction.

Improving striping operations through system optimization.

DOT National Transportation Integrated Search

2015-09-01

Striping operations generate a significant workload for Missouri Department of Transportation (MoDOT) maintenance : operations. The requirement for each striping crew to replenish its stock of paint and other consumable items from a bulk storage : fa...

Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse

PubMed Central

Mendoza Schulz, Alejandro; Jing, Zhizi; María Sánchez Caro, Juan; Wetzel, Friederike; Dresbach, Thomas; Strenzke, Nicola; Wichmann, Carolin; Moser, Tobias

2014-01-01

Endbulb of Held terminals of auditory nerve fibers (ANF) transmit auditory information at hundreds per second to bushy cells (BCs) in the anteroventral cochlear nucleus (AVCN). Here, we studied the structure and function of endbulb synapses in mice that lack the presynaptic scaffold bassoon and exhibit reduced ANF input into the AVCN. Endbulb terminals and active zones were normal in number and vesicle complement. Postsynaptic densities, quantal size and vesicular release probability were increased while vesicle replenishment and the standing pool of readily releasable vesicles were reduced. These opposing effects canceled each other out for the first evoked EPSC, which showed unaltered amplitude. We propose that ANF activity deprivation drives homeostatic plasticity in the AVCN involving synaptic upscaling and increased intrinsic BC excitability. In vivo recordings from individual mutant BCs demonstrated a slightly improved response at sound onset compared to ANF, likely reflecting the combined effects of ANF convergence and homeostatic plasticity. Further, we conclude that bassoon promotes vesicular replenishment and, consequently, a large standing pool of readily releasable synaptic vesicles at the endbulb synapse. PMID:24442636

Maintaining stable radiation pressure acceleration of ion beams via cascaded electron replenishment

NASA Astrophysics Data System (ADS)

Shen, X. F.; Qiao, B.; Chang, H. X.; Zhang, W. L.; Zhang, H.; Zhou, C. T.; He, X. T.

2017-03-01

A method to maintain ion stable radiation pressure acceleration (RPA) from laser-irradiated thin foils is proposed, where a series of high-Z nanofilms are placed behind to successively replenish co-moving electrons into the accelerating foil as electron charging stations (ECSs). Such replenishment of co-moving electrons, on the one hand, helps to keep a dynamic balance between the electrostatic pressure in the accelerating slab and the increasing laser radiation pressure with a Gaussian temporal profile at the rising front, i.e. dynamically matching the optimal condition of RPA; on the other hand, it aids in suppressing the foil Coulomb explosion due to loss of electrons induced by transverse instabilities during RPA. Two-dimensional and three-dimensional particle-in-cell simulations show that a monoenergetic Si14+ beam with a peak energy of 3.7 GeV and particle number 4.8× {10}9 (charge 11 nC) can be obtained at an intensity of 7 × 1021 W cm-2 and the conversion efficiency from laser to high energy ions is improved significantly by using the ECSs in our scheme.

[The study of medical supplies automation replenishment algorithm in hospital on medical supplies supplying chain].

PubMed

Sheng, Xi

2012-07-01

The thesis aims to study the automation replenishment algorithm in hospital on medical supplies supplying chain. The mathematical model and algorithm of medical supplies automation replenishment are designed through referring to practical data form hospital on the basis of applying inventory theory, greedy algorithm and partition algorithm. The automation replenishment algorithm is proved to realize automatic calculation of the medical supplies distribution amount and optimize medical supplies distribution scheme. A conclusion could be arrived that the model and algorithm of inventory theory, if applied in medical supplies circulation field, could provide theoretical and technological support for realizing medical supplies automation replenishment of hospital on medical supplies supplying chain.

A Technique for Evaluating Vendor Bids for Stock Replenishment of a Consumable Item.

DTIC Science & Technology

1985-06-01

RD-A159 957 A TECHNIQUE FOR EVALUATING VENDOR BIDS FOR STOCK 1/1 REPLENISHMENT OF A CONSUMABLE I TEM(U) NAVAL POSTGRADUATE SCHOOL MONTEREY CA J...REPORT II PER106 COVERED *A Technique for Evaluating Vendor Bids Juner’ 1985 i for Stock Replenishment of a Consumable tern 6. PERFORMING ORG. REPORT...Control Center (SPCC) Uniform Inventory Control Program (UICP) wholesale replenishment model for 1H cognizance symbol ( consumable ) material is an order

Effect of geometrical configuration of sediment replenishment on the development of bed form patterns in a gravel bed channel

NASA Astrophysics Data System (ADS)

Battisacco, Elena; Franca, Mário J.; Schleiss, Anton J.

2016-04-01

Dams interrupt the longitudinal continuity of river reaches since they store water and trap sediment in the upstream reservoir. By the interruption of the sediment continuum, the transport capacity of downstream stretch exceeds the sediment supply, thus the flow becomes "hungry". Sediment replenishment is an increasingly used method for restoring the continuity in rivers and for re-establishing the sediment regime of such disturbed river reaches. This research evaluates the effect of different geometrical configurations of sediment replenishment on the evolution of the bed morphology by systematic laboratory experiments. A typical straight armoured gravel reach is reproduced in a laboratory flume in terms of slope, grain size and cross section. The total amount of replenished sediment is placed in four identical volumes on both channel banks, forming six different geometrical configurations. Both alternated and parallel combinations are studied. Preliminary studies demonstrate that a complete submergence condition of the replenishment deposits is most adequate for obtaining a complete erosion and a high persistence of the replenished material in the channel. The response of the channel bed morphology to replenishment is documented by camera and laser scanners installed on a moveable carriage. The parallel configurations create an initially strong narrowing of the channel section. The transport capacity is thus higher and most of the replenished sediments exit the channel. The parallel configurations result in a more spread distribution of grains but with no clear morphological pattern. Clear bed form patterns can be observed when applying alternated configurations. Furthermore, the wavelength of depositions correspond to the replenishment deposit length. These morphological forms can be assumed as mounds. In order to enhance channel bed morphology on an armoured bed by sediment replenishment, alternated deposit configurations are more favourable and effective. The present study is supported by FOEN (Federal Office for the Environment, Switzerland).

Improving striping operations through system optimization - phase 2 : final report.

DOT National Transportation Integrated Search

2016-07-01

Striping operations generate a significant workload for MoDOT maintenance operations. The requirement for each striping crew : to replenish its stock of paint and other consumable items from a bulk storage facility, along with the necessity to make s...

Harvesting and replenishment policies for renewable natural resources

USGS Publications Warehouse

Douglas, Aaron J.; Johnson, Richard L.

1993-01-01

The current paper links the optimal intertemporal use of renewable natural resources to the harvesting activities of various economic agents. Previous contributions cite market forces as a causative factor inducing the extirpation of renewable natural resources. The analysis given here discusses investment in the stock of renewable resources and cites important examples of this activity. By introducing joint harvesting and replenishment strategies into a model of renewable resource use, the analysis adds descriptive reality and relevance to positive and normative discussions of renewable natural resource use. A high price for the yield or a high discount rate tend to diminish the size of the optimum stationary stock of the resource with a non-replenishment harvesting strategy. Optimal non-replenishment harvesting strategies for renewable natural resources will exhaustion or extirpation of the resource if the price of the yield or the discount rate are sufficiently large. However, the availability of a replenishment technology and the use of replenishment activities tends to buffer the resource against exhaustion or extirpation.

Donor understandings of blood and the body in relation to more frequent donation.

PubMed

Lynch, R; Cohn, S

2018-05-01

The INTERVAL trial aimed to find the optimum frequency of blood donation to enhance blood supplies and maintain donor health. This not only requires biological knowledge, but also an appreciation of donor perspectives, and how their experiences and beliefs might be central if any changes are ever to be made. To address this, trial participants were interviewed about their ideas of blood and the body in relation to their experiences of increased donation frequency. Thirty in depth face-to-face interviews conducted with blood donors participating in the trial. Three key themes emerged: ideas about how blood and iron reserves are replenished, and what people did to facilitate this; beliefs about physiological differences relating to age and gender; and practical issues that affected the experience of donation. Overall, participants interviewed welcomed more frequent donation, despite a range of pragmatic concerns. Despite some practical obstacles, increased donation frequency aligned with participant's ideas about bodily replenishment, the value of donation, and their identity as enduring blood donors. They therefore supported the idea of increasing frequency of donation, independently of the biomedical evidence from the trial itself. © 2018 International Society of Blood Transfusion.

Insight into the risk of replenishing urban landscape ponds with reclaimed wastewater.

PubMed

Chen, Rong; Ao, Dong; Ji, Jiayuan; Wang, Xiaochang C; Li, Yu-You; Huang, Yue; Xue, Tao; Guo, Hongbing; Wang, Nan; Zhang, Lu

2017-02-15

Increasing use of reclaimed wastewater (RW) for replenishing urban landscape ponds has aroused public concern about the water quality. Three ponds replenished with RW in three cities in China were chosen to investigate 22 indexes of water quality in five categories. This was achieved by comparing three pairs of ponds in the three different cities, where one pond in each pair was replenished with RW and the other with surface water (SW). The nutrients condition, heavy metal concentration and ecotoxicity did not differ significantly between RW- and SW-replenished ponds. By contrast, significant differences were observed in algal growth and pathogen risk. RW ponds presented a Cyanophyta-Chlorophyta-Bacillariophyta type with high algal diversity while SW ponds presented a Cyanophyta type with low diversity. Regrowth of bacterial pathogens and especially survival of viral pathogens in RW, was the main driver behind the higher risk for RW ponds compared with SW ones. The duration of RW replenishment was proved to have a marked impact on the algal growth and pathogen risk. With continued RW replenishment, non-dominant algal species subjected to decrease while dominant species were enhanced resulting in the biomass increasing but diversity declining, and the risk posed by viral pathogens might become greater. Copyright © 2016 Elsevier B.V. All rights reserved.

A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held

PubMed Central

Guo, Jun; Ge, Jian-long; Hao, Mei; Sun, Zhi-cheng; Wu, Xin-sheng; Zhu, Jian-bing; Wang, Wei; Yao, Pan-tong; Lin, Wei; Xue, Lei

2015-01-01

Although vesicle replenishment is critical in maintaining exo-endocytosis recycling, the underlying mechanisms are not well understood. Previous studies have shown that both rapid and slow endocytosis recycle into a very large recycling pool instead of within the readily releasable pool (RRP), and the time course of RRP replenishment is slowed down by more intense stimulation. This finding contradicts the calcium/calmodulin-dependence of RRP replenishment. Here we address this issue and report a three-pool model for RRP replenishment at a central synapse. Both rapid and slow endocytosis provide vesicles to a large reserve pool (RP) ~42.3 times the RRP size. When moving from the RP to the RRP, vesicles entered an intermediate pool (IP) ~2.7 times the RRP size with slow RP-IP kinetics and fast IP-RRP kinetics, which was responsible for the well-established slow and rapid components of RRP replenishment. Depletion of the IP caused the slower RRP replenishment observed after intense stimulation. These results establish, for the first time, a realistic cycling model with all parameters measured, revealing the contribution of each cycling step in synaptic transmission. The results call for modification of the current view of the vesicle recycling steps and their roles. PMID:25825223

Continuous replenishment of molten semiconductor in a Czochralski-process, single-crystal-growing furnace

NASA Technical Reports Server (NTRS)

Fiegl, George (Inventor); Torbet, Walter (Inventor)

1981-01-01

A replenishment crucible is mounted adjacent the usual drawing crucible, from which a monocrystalline boule is drawn according to the Czochralski method. A siphon tube for molten semiconductor transfer extends from the replenishment crucible to the drawing crucible. Each crucible is enclosed within its own hermetic shell and is provided with its own heater. The siphon tube is initially filled with molten semiconductor by raising the inert atmospheric pressure in the shell surrounding the replenishment crucible above that surrounding the drawing crucible. Thereafter, adjustment of the level of molten semiconductor in the drawing crucible may be achieved by adjusting the level in either crucible, since the siphon tube will establish the same level in both crucibles. For continuous processing, solid semiconductor may be added to and melted in the replenishment crucible during the process of drawing crystals from the drawing crucible. A constant liquid level of melted semiconductor is maintained in the system by an optical monitoring device and any of several electromechanical controls of the rate of replenishment or crucible height.

Replenishment policy for an inventory model under inflation

NASA Astrophysics Data System (ADS)

Singh, Vikramjeet; Saxena, Seema; Singh, Pushpinder; Mishra, Nitin Kumar

2017-07-01

The purpose of replenishment is to keep the flow of inventory in the system. To determine an optimal replenishment policy is a great challenge in developing an inventory model. Inflation is defined as the rate at which the prices of goods and services are rising over a time period. The cost parameters are affected by the rate of inflation. High rate of inflation affects the organizations financial conditions. Based on the above backdrop the present paper proposes the retailers replenishment policy for deteriorating items with different cycle lengths under inflation. The shortages are partially backlogged. At last numerical examples validate the results.

Silicon dendritic web growth

NASA Technical Reports Server (NTRS)

Duncan, S.

1984-01-01

Technological goals for a silicon dendritic web growth program effort are presented. Principle objectives for this program include: (1) grow long web crystals front continuously replenished melt; (2) develop temperature distribution in web and melt; (3) improve reproductibility of growth; (4) develop configurations for increased growth rates (width and speed); (5) develop new growth system components as required for improved growth; and (6) evaluate quality of web growth.

Segregation control in vertical Bridgman crystal growth

NASA Astrophysics Data System (ADS)

Tao, Y.; Kou, S.

1996-11-01

To help the crystal grow at a constant dopant concentration in vertical Bridgman crystal growth, the dopant concentration of the growth melt, i.e. the melt from which the crystal grows, was kept constant. To achieve this, three different methods were used to replenish the growth melt at a controlled rate and suppress dopant diffusion between the growth melt and the replenishing melt. In method one, a replenishing crucible having a long melt passageway was immersed in the growth melt. In method two, a replenishing crucible having an independent feed-rate control mechanism was held above the growth melt. In method three, a submerged diffusion baffle was used to form a long melt passageway between the growth melt and the replenishing melt. NaNO 3 was used as a model material for crystal growth. Single crystals were grown by these three methods with effective segregation control. Method two was applied to InSb and single crystals were also grown with effective segregation control.

A supplier selection and order allocation problem with stochastic demands

NASA Astrophysics Data System (ADS)

Zhou, Yun; Zhao, Lei; Zhao, Xiaobo; Jiang, Jianhua

2011-08-01

We consider a system comprising a retailer and a set of candidate suppliers that operates within a finite planning horizon of multiple periods. The retailer replenishes its inventory from the suppliers and satisfies stochastic customer demands. At the beginning of each period, the retailer makes decisions on the replenishment quantity, supplier selection and order allocation among the selected suppliers. An optimisation problem is formulated to minimise the total expected system cost, which includes an outer level stochastic dynamic program for the optimal replenishment quantity and an inner level integer program for supplier selection and order allocation with a given replenishment quantity. For the inner level subproblem, we develop a polynomial algorithm to obtain optimal decisions. For the outer level subproblem, we propose an efficient heuristic for the system with integer-valued inventory, based on the structural properties of the system with real-valued inventory. We investigate the efficiency of the proposed solution approach, as well as the impact of parameters on the optimal replenishment decision with numerical experiments.

Advanced dendritic web growth development and development of single-crystal silicon dendritic ribbon and high-efficiency solar cell program

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Seidensticker, R. G.; Mchugh, J. P.; Hopkins, R. H.

1986-01-01

Efforts to demonstrate that the dendritic web technology is ready for commercial use by the end of 1986 continues. A commercial readiness goal involves improvements to crystal growth furnace throughput to demonstrate an area growth rate of greater than 15 sq cm/min while simultaneously growing 10 meters or more of ribbon under conditions of continuous melt replenishment. Continuous means that the silicon melt is being replenished at the same rate that it is being consumed by ribbon growth so that the melt level remains constant. Efforts continue on computer thermal modeling required to define high speed, low stress, continuous growth configurations; the study of convective effects in the molten silicon and growth furnace cover gas; on furnace component modifications; on web quality assessments; and on experimental growth activities.

An Analysis of Causes of Contract Price Change for Competitive Procurements of Replenishment Spare Parts.

DTIC Science & Technology

1984-09-01

Research Study Number Three. In 1982, Mr. Edward Brost , then a graduate student at AFIT, completed a thesis which further analyzed the effects of sole...task, Brost formulated three research questions. They are as follows: 1. Is there a reduction in replenishment spare parts prices when competition is...analysis, Brost made three significant conclusions. They are: 1. The introduction of competition into the replenishment spare parts acquisition process

Design and Evaluation of a Clock Multiplexing Circuit for the SSRL Booster Accelerator Timing System - Final Paper

DOE Office of Scientific and Technical Information (OSTI.GOV)

Araya, Million

2015-08-21

SPEAR3 is a 234 m circular storage ring at SLAC’s synchrotron radiation facility (SSRL) in which a 3 GeV electron beam is stored for user access. Typically the electron beam decays with a time constant of approximately 10hr due to electron lose. In order to replenish the lost electrons, a booster synchrotron is used to accelerate fresh electrons up to 3GeV for injection into SPEAR3. In order to maintain a constant electron beam current of 500mA, the injection process occurs at 5 minute intervals. At these times the booster synchrotron accelerates electrons for injection at a 10Hz rate. A 10Hzmore » 'injection ready' clock pulse train is generated when the booster synchrotron is operating. Between injection intervals-where the booster is not running and hence the 10 Hz ‘injection ready’ signal is not present-a 10Hz clock is derived from the power line supplied by Pacific Gas and Electric (PG&E) to keep track of the injection timing. For this project I constructed a multiplexing circuit to 'switch' between the booster synchrotron 'injection ready' clock signal and PG&E based clock signal. The circuit uses digital IC components and is capable of making glitch-free transitions between the two clocks. This report details construction of a prototype multiplexing circuit including test results and suggests improvement opportunities for the final design.« less

Mammography film processor replenishment rate: bromide level monitoring.

PubMed

Kimme-Smith, C; Wuelfing, P; Kitts, E L; Cagnon, C; Basic, M; Bassett, L

1997-03-01

The effects of the mammography film processing replenishment rate on contrast and speed are studied sensitometrically. Two experiments studied decreasing replenishment rates in the Kodak RP developer and quantified changes in the developer by measuring bromide ion concentrations. First, values of NaBr concentration from 1.7 to 8.4 g/L, achieved by reducing the replenishment rate, were tested with sensitometry strips. Second, the developer replenishment rate of a high volume dedicated mammography processor was reduced by one-third, to 20 cm3/1560 cm2, so that the NaBr concentration rose from 2.0 to 12.36. Sensitometric results for four film types and patient films were tested for changes from standard values as NaBr concentration was restored to 3.31 g/L. Fifty-five clinical images obtained at 7.3-9.3 NaBr g/L were compared to their matching previous films, with NaBr levels of 2-3 g/L, for contrast and visibility of the skin line. For the range of the NaBr ion from 1.7 to 7 g/L, no significant sensitometric differences were found. Above 7 g/L, different film types had different sensitometric results. From 7.3 to 9.3 NaBr g/L, 47.5% of the clinical films reviewed by four radiologists had less contrast compared to previous films. Dedicated mammography processors with high film volume (i.e., those that do not have excessive oxidation or foreign dye problems) can operate at lower replenishment rates than are currently employed. All common mammography film types are stable at these lower replenishment rates up to 7.0 NaBr g/L.

Genetic Connectivity among and Self-Replenishment within Island Populations of a Restricted Range Subtropical Reef Fish

PubMed Central

van der Meer, Martin H.; Hobbs, Jean-Paul A.; Jones, Geoffrey P.; van Herwerden, Lynne

2012-01-01

Marine protected areas (MPAs) are increasingly being advocated and implemented to protect biodiversity on coral reefs. Networks of appropriately sized and spaced reserves can capture a high proportion of species diversity, with gene flow among reserves presumed to promote long term resilience of populations to spatially variable threats. However, numerically rare small range species distributed among isolated locations appear to be at particular risk of extinction and the likely benefits of MPA networks are uncertain. Here we use mitochondrial and microsatellite data to infer evolutionary and contemporary gene flow among isolated locations as well as levels of self-replenishment within locations of the endemic anemonefish Amphiprion mccullochi, restricted to three MPA offshore reefs in subtropical East Australia. We infer high levels of gene flow and genetic diversity among locations over evolutionary time, but limited contemporary gene flow amongst locations and high levels of self-replenishment (68 to 84%) within locations over contemporary time. While long distance dispersal explained the species’ integrity in the past, high levels of self-replenishment suggest locations are predominantly maintained by local replenishment. Should local extinction occur, contemporary rescue effects through large scale connectivity are unlikely. For isolated islands with large numbers of endemic species, and high local replenishment, there is a high premium on local species-specific management actions. PMID:23185398

The anti-hepatitis drug use effect and inventory management optimization from the perspective of hospital drug supply chain.

PubMed

Liu, Zhanyu

2017-09-01

By analyzing the current hospital anti hepatitis drug use, dosage, indications and drug resistance, this article studied the drug inventory management and cost optimization. The author used drug utilization evaluation method, analyzed the amount and kind distribution of anti hepatitis drugs and made dynamic monitoring of inventory. At the same time, the author puts forward an effective scheme of drug classification management, uses the ABC classification method to classify the drugs according to the average daily dose of drugs, and implements the automatic replenishment plan. The design of pharmaceutical services supply chain includes drug procurement platform, warehouse management system and connect to the hospital system through data exchange. Through the statistical analysis of drug inventory, we put forward the countermeasures of drug logistics optimization. The results showed that drug replenishment plan can effectively improve drugs inventory efficiency.

Biofuels: What Are They and How Can They Improve Practical Work and Discussions?

ERIC Educational Resources Information Center

MacLean, Tristan

2014-01-01

This article looks at the potential of bioenergy as a replacement for fossil fuels, the cutting-edge research being undertaken by scientists, and classroom resources available for teaching this topic. There is currently a large programme of scientific research aiming to develop advanced biofuels (replenishable liquid biofuels from non-food plants,…

An Analysis of the Defense Logistics Agency Medical Supplies Requisition Process

DTIC Science & Technology

1991-09-01

Flowchart of the Improvement Process .... ....... 8 2. Generic Order Processing Flow .. .......... 19 3. Total Order Cycle: A Customer’s Perspective . 20 4...concentrated in the area of order processing and how it can be improved, especially in the medical supplies arena. This chapter is divided into four major...1989b:l). This time period may be also referred to as lead time, or the replenishment cycle. Figure 2 illustrates a generic order processing flow, which

41 CFR 101-27.102-2 - Guidelines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Replenishment § 101-27.102-2 Guidelines. Guidelines for implementing the EOQ principle of stock replenishment are in the GSA Handbook, The Economic Order Quantity Principle and Applications, issued by the Federal...

Optimal dynamic pricing and replenishment policy for perishable items with inventory-level-dependent demand

NASA Astrophysics Data System (ADS)

Lu, Lihao; Zhang, Jianxiong; Tang, Wansheng

2016-04-01

An inventory system for perishable items with limited replenishment capacity is introduced in this paper. The demand rate depends on the stock quantity displayed in the store as well as the sales price. With the goal to realise profit maximisation, an optimisation problem is addressed to seek for the optimal joint dynamic pricing and replenishment policy which is obtained by solving the optimisation problem with Pontryagin's maximum principle. A joint mixed policy, in which the sales price is a static decision variable and the replenishment rate remains to be a dynamic decision variable, is presented to compare with the joint dynamic policy. Numerical results demonstrate the advantages of the joint dynamic one, and further show the effects of different system parameters on the optimal joint dynamic policy and the maximal total profit.

Terrorism in the Maritime Domain

DTIC Science & Technology

2013-03-01

Indonesia-based terrorist group formed in the early 1990s to establish an Islamic state encompassing southern Thailand, Malaysia , Singapore, Indonesia...overseas. There are instances where the warships need to replenish their fuel and food supplies in a foreign country’s harbor. The terrorist group...initiated to improve the maritime domain awareness in the tri-border area (TBA) between the Philippines, Malaysia , and Indonesia, where terrorist

On the risks from sediment and overlying water by replenishing urban landscape ponds with reclaimed wastewater.

PubMed

Ao, Dong; Chen, Rong; Wang, Xiaochang C; Liu, Yanzheng; Dzakpasu, Mawuli; Zhang, Lu; Huang, Yue; Xue, Tao; Wang, Nan

2018-05-01

The extensive use of reclaimed wastewater (RW) as a source of urban landscape pond replenishment, stimulated by the lack of surface water (SW) resources, has raised public concern. Greater attention should be paid to pond sediments, which act as 'sinks' and 'sources' of contaminants to the overlying pond water. Three ponds replenished with RW (RW ponds) in three Chinese cities were chosen to investigate 22 indices of sediment quality in four categories: eutrophication, heavy metal, ecotoxicity and pathogens risk. RW ponds were compared with other ponds of similar characteristics in the same cities that were replenished with SW (SW ponds). Our results show a strong impact of RW to the eutrophication and pathogenic risks, which are represented by organic matter, water content, total nitrogen, total phosphorus and phosphorus fractions, and pathogens. In particular, total phosphorus concentrations in the RW pond sediments were, on average, 50% higher than those of SW ponds. Moreover, the content of phosphorus, extracted by bicarbonate/dithionite (normally represented by BD-P) and NaOH (NaOH-P), were 2.0- and 2.83-times higher in RW ponds, respectively. For pathogens, the concentrations of norovirus and rotavirus in RW pond sediments were, on average, 0.52 and 0.30- log times those of SW ponds. The duration of RW replenishment was proved to have a marked impact on the eutrophication and pathogens risks from sediments. The continued use of RW for replenishment increases the eutrophication risk, and the pathogens risk, especially by viral pathogens, becomes greater. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Quantitative Study of Vertical Replenishment and its Contribution to Momentum Recovery for a Large Offshore Windfarm

NASA Astrophysics Data System (ADS)

Gupta, T.; Baidya Roy, S.; Miller, L.

2017-12-01

With rapid increase in the installed wind capacity around the globe, it is important and interesting to understand the processes involved in wind farm-atmospheric boundary layer interactions. A wind turbine extracts energy from the mean flow and converts it into electrical energy, thereby reducing the mean kinetic energy available. The corresponding reduction in momentum triggers vertical mixing that transports high-momentum air from aloft to the wind turbine layer thereby replenishing the lost momentum, at least partially. This study investigates the phenomenon of vertical replenishment and quantifies its contribution in the momentum recovery as a function of various factors including installed capacity (MW/km2), depth of the wind farm (km) and climatology of the area. Numerical experiments are conducted using the WRF mesoscale model to simulate wind turbine-boundary layer interactions in a hypothetical large off-shore wind farm located deep in the Arabian Sea off the western coast of India. WRF is equipped with a wind turbine parameterization and is capable of simulating both the momentum reduction and vertical replenishment phenomena. It is found that the downward turbulent flux is able to replenish about 66% of momentum lost because of wind turbines. Additionally, the feedback leads to an average increase of 1.5% in generated power capacity in the wind farm. These results indicate that when the momentum deficit occurs, the vertical replenishment in form of turbulent flux tries to dampen the momentum loss, hence, acting as a negative feedback in the wind farm.

[Investigation on chromatogram-pharmacodynamics relationship of Angelica sinensis on effect of replenishing blood].

PubMed

Yang, Ying-Lai; Cui, Fang; Hu, Fang; Guo, Long; Yang, Tao; Li, Ying-Dong; Feng, Shi-Lan

2013-11-01

Blood deficiency model of mice was copied by subcutaneous injection with 200, 100 and 100 mg x kg(-1) (0.01 mL x g(-1)) acetyl phenylhydrazine (APH) at the frist, fourth, and seventh days. Mice in each group were perfused with different extracted parts of Angelica sinensis (drug dosage was 2.4 g x kg(-1)) at the tenth day, once a day for 10 days. Then compare the influence of different extracted parts of Angelica sinensis to RBC, Hb, PLT and thymus, spleen and weight changes of blood deficiency mice. The peak areas of each common peak from HPLC fingerprint were associated with the date of replenishing blood pharmacodynamics efficacy by using gray relation statistic, which was used to research the chromatogram-pharmacodynamics relationship. The results showed that the part of DSC has the better effect in replenishing blood. The contribution degree of the DSC to replenishing blood of each component were determined by correlation size, and ferulic acid made the largest contribution, but contribution of other components should not be ignored. In this paper, we research the relationship of the HPLC fingerprint and spectrum activity relationship, determine the material basis of the DSC for replenishing blood, and provide effective way to represent the spectral correlation effect.

The Optimization Based Dynamic and Cyclic Working Strategies for Rechargeable Wireless Sensor Networks with Multiple Base Stations and Wireless Energy Transfer Devices

PubMed Central

Ding, Xu; Han, Jianghong; Shi, Lei

2015-01-01

In this paper, the optimal working schemes for wireless sensor networks with multiple base stations and wireless energy transfer devices are proposed. The wireless energy transfer devices also work as data gatherers while charging sensor nodes. The wireless sensor network is firstly divided into sub networks according to the concept of Voronoi diagram. Then, the entire energy replenishing procedure is split into the pre-normal and normal energy replenishing stages. With the objective of maximizing the sojourn time ratio of the wireless energy transfer device, a continuous time optimization problem for the normal energy replenishing cycle is formed according to constraints with which sensor nodes and wireless energy transfer devices should comply. Later on, the continuous time optimization problem is reshaped into a discrete multi-phased optimization problem, which yields the identical optimality. After linearizing it, we obtain a linear programming problem that can be solved efficiently. The working strategies of both sensor nodes and wireless energy transfer devices in the pre-normal replenishing stage are also discussed in this paper. The intensive simulations exhibit the dynamic and cyclic working schemes for the entire energy replenishing procedure. Additionally, a way of eliminating “bottleneck” sensor nodes is also developed in this paper. PMID:25785305

The optimization based dynamic and cyclic working strategies for rechargeable wireless sensor networks with multiple base stations and wireless energy transfer devices.

PubMed

Ding, Xu; Han, Jianghong; Shi, Lei

2015-03-16

In this paper, the optimal working schemes for wireless sensor networks with multiple base stations and wireless energy transfer devices are proposed. The wireless energy transfer devices also work as data gatherers while charging sensor nodes. The wireless sensor network is firstly divided into sub networks according to the concept of Voronoi diagram. Then, the entire energy replenishing procedure is split into the pre-normal and normal energy replenishing stages. With the objective of maximizing the sojourn time ratio of the wireless energy transfer device, a continuous time optimization problem for the normal energy replenishing cycle is formed according to constraints with which sensor nodes and wireless energy transfer devices should comply. Later on, the continuous time optimization problem is reshaped into a discrete multi-phased optimization problem, which yields the identical optimality. After linearizing it, we obtain a linear programming problem that can be solved efficiently. The working strategies of both sensor nodes and wireless energy transfer devices in the pre-normal replenishing stage are also discussed in this paper. The intensive simulations exhibit the dynamic and cyclic working schemes for the entire energy replenishing procedure. Additionally, a way of eliminating "bottleneck" sensor nodes is also developed in this paper.

Assessment of offshore New Jersey sources of Beach replenishment sand by diversified application of geologic and geophysical methods

USGS Publications Warehouse

Waldner, J.S.; Hall, D.W.; Uptegrove, J.; Sheridan, R.E.; Ashley, G.M.; Esker, D.

1999-01-01

Beach replenishment serves the dual purpose of maintaining a source of tourism and recreation while protecting life and property. For New Jersey, sources for beach sand supply are increasingly found offshore. To meet present and future needs, geologic and geophysical techniques can be used to improve the identification, volume estimation, and determination of suitability, thereby making the mining and managing of this resource more effective. Current research has improved both data collection and interpretation of seismic surveys and vibracore analysis for projects investigating sand ridges offshore of New Jersey. The New Jersey Geological Survey in cooperation with Rutgers University is evaluating the capabilities of digital seismic data (in addition to analog data) to analyze sand ridges. The printing density of analog systems limits the dynamic range to about 24 dB. Digital acquisition systems with dynamic ranges above 100 dB can permit enhanced seismic profiles by trace static correction, deconvolution, automatic gain scaling, horizontal stacking and digital filtering. Problems common to analog data, such as wave-motion effects of surface sources, water-bottom reverberation, and bubble-pulse-width can be addressed by processing. More than 160 line miles of digital high-resolution continuous profiling seismic data have been collected at sand ridges off Avalon, Beach Haven, and Barnegat Inlet. Digital multichannel data collection has recently been employed to map sand resources within the Port of New York/New Jersey expanded dredge-spoil site located 3 mi offshore of Sandy Hook, New Jersey. Multichannel data processing can reduce multiples, improve signal-to-noise calculations, enable source deconvolution, and generate sediment acoustic velocities and acoustic impedance analysis. Synthetic seismograms based on empirical relationships among grain size distribution, density, and velocity from vibracores are used to calculate proxy values for density and velocity. The seismograms are then correlated to the digital seismic profile to confirm reflected events. They are particularly useful where individual reflection events cannot be detected but a waveform generated by several thin lithologic units can be recognized. Progress in application of geologic and geophysical methods provides advantages in detailed sediment analysis and volumetric estimation of offshore sand ridges. New techniques for current and ongoing beach replenishment projects not only expand our knowledge of the geologic processes involved in sand ridge origin and development, but also improve our assessment of these valuable resources. These reconnaissance studies provide extensive data to the engineer regarding the suitability and quantity of sand and can optimize placement and analysis of vibracore samples.Beach replenishment serves the dual purpose of maintaining a source of tourism and recreation while protecting life and property. Research has improved both data collection and interpretation of seismic surveys and vibracore analysis for projects investigating sand ridges offshore of New Jersey. The New Jersey Geological Survey in cooperation with Rutgers University is evaluating the capabilities of digital seismic data to analyze sand ridges. The printing density of analog systems limits the dynamic range to about 24 dB. Digital acquisition systems with dynamic ranges about 100 dB can permit enhanced seismic profiles by trace static correction, deconvolution, automatic gain scaling, horizontal stacking and digital filtering.

Replenishing Opportunity in America: The 2012 Midterm Report of Public Higher Education Systems in the Access to Success Initiative

ERIC Educational Resources Information Center

Engle, Jennifer; Yeado, Joseph; Brusi, Rima; Cruz, Jose L.

2012-01-01

To preserve our nation's democratic ideals and compete in the global economy, we must improve postsecondary educational attainment. Indeed, the stakes are so high that prominent government and business leaders have set a goal for the United States to regain its status as the world's most educated country by 2020. Given demographic and…

Attrition analysed in five waves of a longitudinal yearly survey of smokers: findings from the ITC Netherlands survey.

PubMed

Zethof, Dennis; Nagelhout, Gera E; de Rooij, Mark; Driezen, Pete; Fong, Geoffrey T; van den Putte, Bas; Hummel, Karin; de Vries, Hein; Thompson, Mary E; Willemsen, Marc C

2016-08-01

Attrition bias can affect the external validity of findings. This article analyses attrition bias and assesses the effectiveness of replenishment samples on demographic and smoking-related characteristics for the International Tobacco Control Netherlands Survey, a longitudinal survey among smokers. Attrition analyses were conducted for the first five survey waves (2008-12). We assessed, including and excluding replenishment samples, whether the demographic composition of the samples changed between the first and fifth waves. Replenishment samples were tailored to ensure the sample remained representative of the smoking population. We also constructed a multivariable survival model of attrition that included all five waves with replenishment samples. Of the original 1820 respondents recruited in 2008, 46% participated again in 2012. Demographic differences between waves due to attrition were generally small and replenishment samples tended to minimize them further. The multivariable survival analysis revealed that only two of the 10 variables analysed were significant predictors of attrition: a weak effect for gender (men dropped out more often) and weak to moderate effects for age (respondents aged 15-24 years dropped out more than aged 25-39 years, who dropped out more than those aged 40+ years). Weak to moderate attrition effects were found for men and younger age groups. This information could be used to minimize respondent attrition. Our findings suggest that sampling weights and tailored replenishment samples can effectively compensate for attrition effects. This is already being done for the International Tobacco Control Netherlands Survey, including the categories that significantly predicted attrition in this study. © The Author 2016. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

Nectar replenishment maintains the neutral effects of nectar robbing on female reproductive success of Salvia przewalskii (Lamiaceae), a plant pollinated and robbed by bumble bees

PubMed Central

Ye, Zhong-Ming; Jin, Xiao-Fang; Inouye, David W.

2017-01-01

Background and Aims It has been suggested that the dynamics of nectar replenishment could differ for flowers after being nectar robbed or visited legitimately, but further experimental work is needed to investigate this hypothesis. This study aimed to assess the role of nectar replenishment in mediating the effects of nectar robbing on pollinator behaviour and plant reproduction. Methods Plant–robber–pollinator interactions in an alpine plant, Salvia przewalskii, were studied. It is pollinated by long-tongued Bombus religiosus and short-tongued B. friseanus, but robbed by B. friseanus. Nectar production rates for flowers after they were either robbed or legitimately visited were compared, and three levels of nectar robbing were created to detect the effects of nectar robbing on pollinator behaviour and plant reproduction. Key Results Nectar replenishment did not differ between flowers that had been robbed or legitimately visited. Neither fruit set nor seed set was significantly affected by nectar robbing. In addition, nectar robbing did not significantly affect visitation rate, flowers visited within a plant per foraging bout, or flower handling time of the legitimate pollinators. However, a tendency for a decrease in relative abundance of the pollinator B. religiosus with an increase of nectar robbing was found. Conclusions Nectar robbing did not affect female reproductive success because nectar replenishment ensures that pollinators maintain their visiting activity to nectar-robbed flowers. Nectar replenishment might be a defence mechanism against nectar robbing to enhance reproductive fitness by maintaining attractiveness to pollinators. Further studies are needed to reveal the potential for interference competition among bumble bees foraging as robbers and legitimate visitors, and to investigate variation of nectar robbing in communities with different bumble bee species composition. PMID:28158409

Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: Inefficacy of genetic or pharmacological disruption of COX-2

PubMed Central

Fong, Louise Y.Y.; Jiang, Yubao; Riley, Maurisa; Liu, Xianglan; Smalley, Karl J.; Guttridge, Denis C.; Farber, John L.

2009-01-01

Zinc deficiency in humans is associated with an increased risk of upper aerodigestive tract (UADT) cancer. In rodents, zinc deficiency predisposes to carcinogenesis by causing proliferation and alterations in gene expression. We examined whether in zinc-deficient rodents, targeted disruption of the cyclooxygenase (COX)-2 pathway by the COX-2 selective inhibitor celecoxib or by genetic deletion prevent UADT carcinogenesis. Tongue cancer prevention studies were conducted in zinc-deficient rats previously exposed to a tongue carcinogen by celecoxib treatment with or without zinc replenishment, or by zinc replenishment alone. The ability of genetic COX-2 deletion to protect against chemically-induced for-estomach tumorigenesis was examined in mice on zinc-deficient versus zinc-sufficient diet. The expression of 3 predictive bio-markers COX-2, nuclear factor (NF)-κ B p65 and leukotriene A4 hydrolase (LTA4H) was examined by immunohistochemistry. In zinc-deficient rats, celecoxib without zinc replenishment reduced lingual tumor multiplicity but not progression to malignancy. Celecoxib with zinc replenishment or zinc replenishment alone significantly lowered lingual squamous cell carcinoma incidence, as well as tumor multiplicity. Celecoxib alone reduced overexpression of the 3 biomarkers in tumors slightly, compared with intervention with zinc replenishment. Instead of being protected, zinc-deficient COX-2 null mice developed significantly greater tumor multiplicity and forestomach carcinoma incidence than wild-type controls. Additionally, zinc-deficient COX-2−/− forestomachs displayed strong LTA4H immunostaining, indicating activation of an alter-native pathway under zinc deficiency when the COX-2 pathway is blocked. Thus, targeting only the COX-2 pathway in zinc-deficient animals did not prevent UADT carcinogenesis. Our data suggest zinc supplementation should be more thoroughly explored in human prevention clinical trials for UADT cancer. PMID:17985342

Assessment of the performance of numerical modeling in reproducing a replenishment of sediments in a water-worked channel

NASA Astrophysics Data System (ADS)

Juez, C.; Battisacco, E.; Schleiss, A. J.; Franca, M. J.

2016-06-01

The artificial replenishment of sediment is used as a method to re-establish sediment continuity downstream of a dam. However, the impact of this technique on the hydraulics conditions, and resulting bed morphology, is yet to be understood. Several numerical tools have been developed during last years for modeling sediment transport and morphology evolution which can be used for this application. These models range from 1D to 3D approaches: the first being over simplistic for the simulation of such a complex geometry; the latter requires often a prohibitive computational effort. However, 2D models are computationally efficient and in these cases may already provide sufficiently accurate predictions of the morphology evolution caused by the sediment replenishment in a river. Here, the 2D shallow water equations in combination with the Exner equation are solved by means of a weak-coupled strategy. The classical friction approach considered for reproducing the bed channel roughness has been modified to take into account the morphological effect of replenishment which provokes a channel bed fining. Computational outcomes are compared with four sets of experimental data obtained from several replenishment configurations studied in the laboratory. The experiments differ in terms of placement volume and configuration. A set of analysis parameters is proposed for the experimental-numerical comparison, with particular attention to the spreading, covered surface and travel distance of placed replenishment grains. The numerical tool is reliable in reproducing the overall tendency shown by the experimental data. The effect of fining roughness is better reproduced with the approach herein proposed. However, it is also highlighted that the sediment clusters found in the experiment are not well numerically reproduced in the regions of the channel with a limited number of sediment grains.

Optimal ordering quantities for substitutable deteriorating items under joint replenishment with cost of substitution

NASA Astrophysics Data System (ADS)

Mishra, Vinod Kumar

2017-09-01

In this paper we develop an inventory model, to determine the optimal ordering quantities, for a set of two substitutable deteriorating items. In this inventory model the inventory level of both items depleted due to demands and deterioration and when an item is out of stock, its demands are partially fulfilled by the other item and all unsatisfied demand is lost. Each substituted item incurs a cost of substitution and the demands and deterioration is considered to be deterministic and constant. Items are order jointly in each ordering cycle, to take the advantages of joint replenishment. The problem is formulated and a solution procedure is developed to determine the optimal ordering quantities that minimize the total inventory cost. We provide an extensive numerical and sensitivity analysis to illustrate the effect of different parameter on the model. The key observation on the basis of numerical analysis, there is substantial improvement in the optimal total cost of the inventory model with substitution over without substitution.

Low cost solar array project. Task 1: Silicon material, gaseous melt replenishment system

NASA Technical Reports Server (NTRS)

Jewett, D. N.; Bates, H. E.; Hill, D. M.

1979-01-01

A system to combine silicon formation, by hydrogen reduction of trichlorosilane, with the capability to replenish a crystal growth system is described. A variety of process parameters to allow sizing and specification of gas handling system components was estimated.

DUV light source availability improvement via further enhancement of gas management technologies

NASA Astrophysics Data System (ADS)

Riggs, Daniel J.; O'Brien, Kevin; Brown, Daniel J. W.

2011-04-01

The continuous evolution of the semiconductor market necessitates ever-increasing improvements in DUV light source uptime as defined in the SEMI E10 standard. Cymer is developing technologies to exceed current and projected light source availability requirements via significant reduction in light source downtime. As an example, consider discharge chamber gas management functions which comprise a sizable portion of DUV light source downtime. Cymer's recent introduction of Gas Lifetime Extension (GLXTM) as a productivity improvement technology for its DUV lithography light sources has demonstrated noteworthy reduction in downtime. This has been achieved by reducing the frequency of full gas replenishment events from once per 100 million pulses to as low as once per 2 billion pulses. Cymer has continued to develop relevant technologies that target further reduction in downtime associated with light source gas management functions. Cymer's current subject is the development of technologies to reduce downtime associated with gas state optimization (e.g. total chamber gas pressure) and gas life duration. Current gas state optimization involves execution of a manual procedure at regular intervals throughout the lifetime of light source core components. Cymer aims to introduce a product enhancement - iGLXTM - that eliminates the need for the manual procedure and, further, achieves 4 billion pulse gas lives. Projections of uptime on DUV light sources indicate that downtime associated with gas management will be reduced by 70% when compared with GLX2. In addition to reducing downtime, iGLX reduces DUV light source cost of operation by constraining gas usage. Usage of fluorine rich Halogen gas mix has been reduced by 20% over GLX2.

Dynamic microbubble contrast-enhanced US to measure tumor response to targeted therapy: a proposed clinical protocol with results from renal cell carcinoma patients receiving antiangiogenic therapy.

PubMed

Williams, Ross; Hudson, John M; Lloyd, Brendan A; Sureshkumar, Ahthavan R; Lueck, Gordon; Milot, Laurent; Atri, Mostafa; Bjarnason, Georg A; Burns, Peter N

2011-08-01

To develop and implement an evidence-based protocol for characterizing vascular response of renal cell carcinoma (RCC) to targeted therapy by using dynamic contrast material-enhanced (DCE) ultrasonography (US). The study was approved by the institutional research ethics board; written informed consent was obtained from all patients. Seventeen patients (four women; median age, 58 years; range, 42-72 years; 13 men, median age, 62 years; range, 45-81 years) with metastatic RCC were examined by using DCE US before and after 2 weeks of treatment with sunitinib (May 2007 to October 2009). Two contrast agent techniques--bolus injection and disruption-replenishment infusion of microbubbles--were compared. Changes in tumor blood velocity and fractional blood volume were measured with both methods, together with reproducibility and effect of compensation for respiratory motion. Tumor changes were assessed with computed tomography, by using the best response with the Response Evaluation Criteria in Solid Tumors (RECIST) and progression-free survival (PFS). Follow-up RECIST measurements were performed at 6-week intervals until progressive disease was detected. In response to treatment, median tumor fractional blood volume measured with the disruption-replenishment infusion method decreased by 73.2% (interquartile range, 46%-87%) (P < .002), with repeated-measure reproducibility of 9%-15%. Significant decreases were also seen with the bolus method, but with poor correlation of changes in bolus peak (r = 0.46, P = .066) and area under the curve (r = 0.47, P = .058), compared with infusion measurements. Changes in DCE US parameters over 2 weeks did not correlate with PFS and could not be used to predict long-term assessment of best response by using RECIST. Follow-up times ranged 28-501 days; the median was 164 days. DCE US provides reproducible and sensitive assessment of vascular changes in response to antiangiogenic therapy. The disruption-replenishment infusion protocol is a flexible method suitable for many tumor types, but further studies are needed to assess whether this protocol may be predictive of patient outcome. © RSNA, 2011.

Halting Land Subsidence in Tucson, Arizona: Examining the Poroelastic Response to Artificial Recharge

NASA Astrophysics Data System (ADS)

Miller, M. M.; Shirzaei, M.; Argus, D. F.

2017-12-01

Overexploitation of groundwater results in stressed aquifer systems and surface deformation in the form of land subsidence. Differential land subsidence can lead to earth fissures, which threaten buildings and infrastructure. Therefore, careful water management is necessary to ensure aquifer resources are withdrawn and replenished at a sustainable yield to preserve supplies and minimize surface deformation. Tucson, Arizona is a semi-arid desert city that is reliant on a semi-confined alluvial aquifer system for much of the water supply. To understand the poroelastic response of the aquifer system over time, we analyze data from wells equipped with extensometers, InSAR time series, and GPS. From 1990-2005, compaction of fine-grained, aquitard material is measured up to 8.5 mm/yr at well sites equipped with extensometers. This induces permanent aquifer storage volume losses up to 4.1%. Yet, interferograms from Envisat and RadarSAT-2 C-band satellites, which yield multitemporal deformation maps at high resolution, reveal that subsidence remarkably slows by the late 2000s and nearly halts by 2015. We infer this deceleration corresponds to heightened artificial recharge efforts to bank Colorado River water delivered via canal. After groundwater levels recover, residual compaction continues for just a 6.6-year interval, which suggests a high value for vertical hydraulic conductivity up to 9.8 x10-4 m/day. Successful water management and conservation plans help the city preserve existing and replenish depleted groundwater reserves, decelerate land subsidence, and likely reduce the risks associated with earth fissuring.

Cyclic variations in nitrogen uptake rate of soybean plants: ammonium as a nitrogen source

NASA Technical Reports Server (NTRS)

Henry, L. T.; Raper, C. D. Jr

1989-01-01

When NO3- is the sole nitrogen source in flowing solution culture, the net rate of nitrogen uptake by nonnodulated soybean (Glycine max L. Merr. cv Ransom) plants cycles between maxima and minima with a periodicity of oscillation that corresponds with the interval of leaf emergence. Since soybean plants accumulate similar quantities of nitrogen when either NH4+ or NO3- is the sole source in solution culture controlled at pH 6.0, an experiment was conducted to determine if the oscillations in net rate of nitrogen uptake also occur when NH4+ is the nitrogen source. During a 21-day period of vegetative development, net uptake of NH4+ was measured daily by ion chromatography as depletion of NH4+ from a replenished nutrient solution containing 1.0 millimolar NH4+. The net rate of NH4+ uptake oscillated with a periodicity that was similar to the interval of leaf emergence. Instances of negative net rates of uptake indicate that the transition between maxima and minima involved changes in influx and efflux components of net NH4+ uptake.

48 CFR 217.7505 - Limitations on price increases.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Limitations on price... Acquisition of Replenishment Parts 217.7505 Limitations on price increases. This section provides implementing... award, on a sole source basis, a contract for any centrally managed replenishment part when the price of...

Process Redesign of the Norwegian Navy Materiel Command’s Replenishment of Inventory Items

DTIC Science & Technology

1997-12-01

procurement offices into one. The second proposal is to introduce, and use electronic commerce in the replenishment process. It is concluded that both...redesign proposals will reduce administrative lead-time, variability and hence cost. Benefits from an introduction of electronic commerce will yield a yearly

The Rapid Rise in the Cost of Replenishment Spare Parts: Are We Making Progress?

DTIC Science & Technology

1985-09-01

Replenishment Spare Parts, Unpublished Master’s Thesis, Air Force Institute of Technology, Wright-Patterson AFB OH, 1984. 2. Brost , Edward J. A...and P. George Benson. Statistics for Business and Economics (Second Edition). San Francisco: Dellen Publishing Company, 1982. 14. Office of Federal

The Soybean Peptide Vglycin Preserves the Diabetic β-cells through Improvement of Proliferation and Inhibition of Apoptosis.

PubMed

Jiang, Hua; Tong, Yuxing; Yan, Dongjing; Jia, Shaohui; Ostenson, Claes-Goran; Chen, Zhengwang

2015-10-29

Replenishment of insulin-producing pancreatic β-cells would be beneficial in diabetes. The number of β-cells is maintained primarily by self-neogenesis to compensate for β-cell failure, loss or dedifferentiation. We present here a polypeptide vglycin, which was isolated and purified from germinating pea seeds. Vglycin exhibited positive effects in our diabetic models by promoting the proliferation and suppressing the apoptosis and dedifferentiation of β-cells. Vglycin promoted the restoration of β-cells in both young streptozotocin (STZ)-induced type 1 diabetic SD rats and in aged high-fat diet with (or without) STZ-induced type 2 diabetic C57BL/6 mice. We demonstrated that vglycin triggers this positive signaling by activating the insulin receptor and corresponding transcription factors. Impaired insulin sensitivity and glucose tolerance in aged T2DM mice were dramatically improved after long-term vglycin treatment, consistent with the altered level of inflammatory factor IL-1β/6. In addition, energy expenditure and body weights were significantly decreased in the mouse models after vglycin therapy. These results provide insight into the protective effects of vglycin on ameliorating β-cell function in standing glucolipotoxicity. Thus, vglycin may represent a new therapeutic agent for preventing and treating diabetes by replenishing endogenous insulin-positive cells.

78 FR 51098 - Apricots Grown in Designated Counties in Washington; Increased Assessment Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... in the Committee's proposed budget and replenish its reserve. The proposed assessment rate would... to fund a proposed increase in administrative costs and to replenish the reserve. The increased... fee; $1,200 for Committee travel; $1,000 for the annual audit; and $670 for office supplies, insurance...

7 CFR 97.104 - Application or certificate abandoned.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... Failure to replenish viable basic seed within 3 months from the date of request shall result in the... specified in the notice of allowance is not paid within 1 month from the date of the notice, the application... basic seed sample of the variety and shall pay the handling fee for replenishment. Upon request, the...

7 CFR 97.104 - Application or certificate abandoned.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... Failure to replenish viable basic seed within 3 months from the date of request shall result in the... specified in the notice of allowance is not paid within 1 month from the date of the notice, the application... basic seed sample of the variety and shall pay the handling fee for replenishment. Upon request, the...

7 CFR 97.104 - Application or certificate abandoned.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... Failure to replenish viable basic seed within 3 months from the date of request shall result in the... specified in the notice of allowance is not paid within 1 month from the date of the notice, the application... basic seed sample of the variety and shall pay the handling fee for replenishment. Upon request, the...

7 CFR 97.104 - Application or certificate abandoned.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... Failure to replenish viable basic seed within 3 months from the date of request shall result in the... specified in the notice of allowance is not paid within 1 month from the date of the notice, the application... basic seed sample of the variety and shall pay the handling fee for replenishment. Upon request, the...

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

PubMed Central

Ryu, Dongryeol; Zhang, Hongbo; Ropelle, Eduardo R.; Sorrentino, Vincenzo; Mázala, Davi A. G.; Mouchiroud, Laurent; Marshall, Philip L.; Campbell, Matthew D.; Ali, Amir Safi; Knowels, Gary M.; Bellemin, Stéphanie; Iyer, Shama R.; Wang, Xu; Gariani, Karim; Sauve, Anthony A.; Cantó, Carles; Conley, Kevin E.; Walter, Ludivine; Lovering, Richard M.; Chin, Eva R.; Jasmin, Bernard J.; Marcinek, David J.; Menzies, Keir J.; Auwerx, Johan

2017-01-01

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and nicotinamide adenine dinucleotide (NAD+) synthesis, consistent with a potential role for the essential cofactor NAD+ in protecting muscle from metabolic and structural degeneration. Furthermore, the skeletal muscle transcriptomes of patients with Duchene’s muscular dystrophy (DMD) and other muscle diseases were enriched for various poly[adenosine 5’-diphosphate (ADP)–ribose] polymerases (PARPs) and for nicotinamide N-methyltransferase (NNMT), enzymes that are major consumers of NAD+ and are involved in pleiotropic events, including inflammation. In the mdx mouse model of DMD, we observed significant reductions in muscle NAD+ levels, concurrent increases in PARP activity, and reduced expression of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD+ biosynthesis. Replenishing NAD+ stores with dietary nicotinamide riboside supplementation improved muscle function and heart pathology in mdx and mdx/Utr−/− mice and reversed pathology in Caenorhabditis elegans models of DMD. The effects of NAD+ repletion in mdx mice relied on the improvement in mitochondrial function and structural protein expression (α-dystrobrevin and δ-sarcoglycan) and on the reductions in general poly(ADP)-ribosylation, inflammation, and fibrosis. In combination, these studies suggest that the replenishment of NAD+ may benefit patients with muscular dystrophies or other neuromuscular degenerative conditions characterized by the PARP/NNMT gene expression signatures. PMID:27798264

Nectar replenishment maintains the neutral effects of nectar robbing on female reproductive success of Salvia przewalskii (Lamiaceae), a plant pollinated and robbed by bumble bees.

PubMed

Ye, Zhong-Ming; Jin, Xiao-Fang; Wang, Qing-Feng; Yang, Chun-Feng; Inouye, David W

2017-04-01

It has been suggested that the dynamics of nectar replenishment could differ for flowers after being nectar robbed or visited legitimately, but further experimental work is needed to investigate this hypothesis. This study aimed to assess the role of nectar replenishment in mediating the effects of nectar robbing on pollinator behaviour and plant reproduction. Plant-robber-pollinator interactions in an alpine plant, Salvia przewalskii , were studied. It is pollinated by long-tongued Bombus religiosus and short-tongued B. friseanus , but robbed by B. friseanus . Nectar production rates for flowers after they were either robbed or legitimately visited were compared, and three levels of nectar robbing were created to detect the effects of nectar robbing on pollinator behaviour and plant reproduction. Nectar replenishment did not differ between flowers that had been robbed or legitimately visited. Neither fruit set nor seed set was significantly affected by nectar robbing. In addition, nectar robbing did not significantly affect visitation rate, flowers visited within a plant per foraging bout, or flower handling time of the legitimate pollinators. However, a tendency for a decrease in relative abundance of the pollinator B. religiosus with an increase of nectar robbing was found. Nectar robbing did not affect female reproductive success because nectar replenishment ensures that pollinators maintain their visiting activity to nectar-robbed flowers. Nectar replenishment might be a defence mechanism against nectar robbing to enhance reproductive fitness by maintaining attractiveness to pollinators. Further studies are needed to reveal the potential for interference competition among bumble bees foraging as robbers and legitimate visitors, and to investigate variation of nectar robbing in communities with different bumble bee species composition. © The Author 2017. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Zinc Replenishment Reverses Overexpression of the Proinflammatory Mediator S100A8 and Esophageal Preneoplasia in the Rat

PubMed Central

Taccioli, Cristian; Wan, Shao-Gui; Liu, Chang-Gong; Alder, Hansjuerg; Volinia, Stefano; Farber, John L.; Croce, Carlo M.

2009-01-01

Background & Aims Zinc-deficiency is implicated in the pathogenesis of human esophageal cancer. In the rat esophagus, it induces cell proliferation, modulates genetic expression, and enhances carcinogenesis. Zinc-replenishment reverses proliferation and inhibits carcinogenesis. The zinc-deficient rat model allows the identification of biological differences affected by zinc during early esophageal carcinogenesis. Methods We evaluated gene expression profiles of esophageal epithelia from zinc-deficient and replenished rats versus sufficient rats using Affymetrix Rat Genome GeneChip. We characterized the role of the top-upregulated gene S100A8 in esophageal hyperplasia/reversal and in chemically-induced esophageal carcinogenesis in zinc-modulated animals by immunohistochemistry and real-time quantitative polymerase chain reaction. Results The hyperplastic deficient esophagus has a distinct expression signature with the proinflammation-gene S100A8 and S100A9 upregulated 57- and 5-fold. “Response to external stimulus” comprising S100A8 was the only significantly overrepresented biological pathway among the upregulated genes. Zinc-replenishment rapidly restored to control levels the expression of S100A8/A9 and 27 other genes and reversed the hyperplastic phenotype. With its receptor RAGE, co-localization and overexpression of S100A8 protein occurred in the deficient esophagus that overexpressed NF-κB p65 and COX-2 protein. Zinc-replenishment but not by a COX-2 inhibitor reduced the overexpression of these 4 proteins. Additionally, esophageal S100A8/A9 mRNA levels were directly associated with the diverse tumorigenic outcome in zinc-deficient and zinc-replenished rats. Conclusions In vivo zinc regulates S100A8 expression and modulates the link between S100A8-RAGE interaction and downstream NF-κB/COX-2 signaling. The finding that zinc regulates an inflammatory pathway in esophageal carcinogenesis may lead to prevention and therapy for this cancer. PMID:19111725

Modeling of replenishment of sediments on a water-worked gravel bed channel

NASA Astrophysics Data System (ADS)

Juez, Carmelo; Battisacco, Elena; Schleiss, Anton J.; Franca, Mário J.

2016-04-01

The presence of dams causes a sediment deficit downstream. Hence, the surface structure of the riverbeds is altered by this interruption in the sediment continuity and The presence of dams causes a sediment deficit downstream. The surface structure of the riverbed is altered by this interruption in the sediment continuity and becoming water-worked. The main morphological effects verified in these cases are thus the generation of armored layers, bank instability, riverbed incision, changes in the channel width and coarsening of the bed particles. These results impact on the riverbed topographic variability and structure of the bedforms. Surface complexity is thus reduced with further ecological implications. The lack of fine material and surface complexity leads to the loss of aquatic and riparian habitats, limiting the possibilities for fish spawning. Nowadays, the revitalization of disturbed river reaches forms an integral part of river management. Sediment transport and associated channel morphology are understood as key processes for recreating and maintaining aquatic ecosystems. For this purpose several replenishment techniques have been considered in order to supply sediments lacking in the downstream reaches. The replenishment techniques can be seen as a pulse-like addition of sedimentary material that initially disturbs the channel. In this work, the response of the flow to the complementary material which is added in the channel is studied by means of the 2D shallow water equations in combination with the Exner equation. The numerical scheme is built by means of a weakly-coupled treatment between the hydrodynamic and morphodynamic equations leading to an efficient and robust solution. Computational outcomes are compared with experimental data obtained from several replenishment configurations studied in the laboratory. The results are analyzed by means of: (i) temporal evolution of the material spreading, (ii) occupational ratio along the channel which is the area percentage that is covered by the replenishment material, (iii) travel distance of the center of the pulse mass and (iv) effect of the bed fining in the bed shear stress. The results of these experiments assist in further evaluating how water-worked gravel bed channels evolve with artificial replenishment of sediments. This work was funded by the ITN-Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7-PEOPLE-2013-ITN under REA grant agreement n_607394-SEDITRANS. The sediment replenishment experiments were funded by FOEN (Federal Office for the Environment, Switzerland).

Proceedings of the Annual ONR/CADRC Decision-Support Workshop (6th), Held in Quantico, Virginia, on 8-9 Sep 2004. Interoperability

DTIC Science & Technology

2004-11-01

fixed schedule checkups and overhauls), Underway Replenishment (the goal being operation in sea states 3 and higher via technical improvements to...determine whether sufficient local resources are available to deal with current conditions. Scheduling Agent: Assists the Emergency Operations Bureau to...will commence per predefined schedule within 15 minutes) and subsequently alerts its subscribers that the rolling power blackout has commenced. The

12 CFR 221.116 - Bank loans to replenish working capital used to purchase mutual fund shares.

Code of Federal Regulations, 2010 CFR

2010-01-01

... purchase mutual fund shares. 221.116 Section 221.116 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED... Bank loans to replenish working capital used to purchase mutual fund shares. (a) In a situation considered by the Board of Governors, a business concern (X) proposed to purchase mutual fund shares, from...

12 CFR 221.116 - Bank loans to replenish working capital used to purchase mutual fund shares.

Code of Federal Regulations, 2011 CFR

2011-01-01

... purchase mutual fund shares. 221.116 Section 221.116 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED... Bank loans to replenish working capital used to purchase mutual fund shares. (a) In a situation considered by the Board of Governors, a business concern (X) proposed to purchase mutual fund shares, from...

Farming with rocks and minerals: challenges and opportunities.

PubMed

Van Straaten, Peter

2006-12-01

In many parts of the world food security is at risk. One of the biophysical root causes of falling per-capita food production is the declining quality and quantity of soils. To reverse this trend and increase soil fertility soil and plant nutrients have to be replenished. This review provides a literature survey of experiences of using multi-nutrient rock fertilizers for soil fertility enhancement from temperate and tropical environments. Advantages and limitations of the application of rock fertilizers are discussed. Examples are provided from two successful nutrient replenishment projects in Africa where locally available rock fertilizers are used on highly leached acid soils. The potential of combining organic materials alongside rock fertilizers in soil fertility replenishment strategies is stressed.

Research to More Effectively Manage Critical Ground-Water Basins

USGS Publications Warehouse

Nickles, James

2008-01-01

As the regional management agency for two of the most heavily used ground-water basins in California, the Water Replenishment District of Southern California (WRD) plays a vital role in sheparding the water resources of southern Los Angeles County. WRD is using the results of the U.S. Geological Survey (USGS) studies to help more effectively manage the Central and West Coast basins in the most efficient, cost-effective way. In partnership with WRD, the USGS is using the latest research tools to study the geohydrology and geochemistry of the two basins. USGS scientists are: *Drilling and collecting detailed data from over 40 multiple-well monitoring sites, *Conducting regional geohydrologic and geochemical analyses, *Developing and applying a computer simulation model of regional ground-water flow. USGS science is providing a more detailed understanding of ground-water flow and quality. This research has enabled WRD to more effectively manage the basins. It has helped the District improve the efficiency of its spreading ponds and barrier injection wells, which replenish the aquifers and control seawater intrusion into the ground-water system.

A study of the effect of dietary factors and various exercises on the swimming performance of the albino rat.

PubMed

Frenkl, R; Györe, A

1979-01-01

In Experiment 1 a double-phase test diet (high-protein low-carbohydrate phase (HP): 5 days, high-carbohydrate phase (HC): 2 days) was compared to a normal diet by measuring all-out performance in rats trained by steady or interval swimming exercise. The tests carried out on the 8th day showed the swimming performance to be improved to a similar extent by the two training procedures, to be further improved by the test diet in the exercised animals; changes in liver glycogen, blood glucose and serum corticosterone reflected especially in the influence of exercise which in some cases was potentiated by the test diet. In Experiment 2 the 5 days of high protein intake were treated separately from the effect of the double-phase test diet as a whole in order to study the mechanism. These aminals were exercised by treadmill running of 7 days. Cytochrome P450 content of the liver rose under the effect of exercise as well as the HP phase, thus supplying additional evidence for the enzyme inducer effect of physical exertion. Glycogen decreased both in the muscle and liver during the HP phase and returned to normal after the HC phase. Liver glycogen rose to an even higher level than normal in the trained groups, but muscle glycogen values remained lower, this may be related to the shortness of training and to an accelerated rate of turnover. High protein intake associated with a depletion of carbohydrate stores was found to have an effect of its own which, when followed by replenishment of calories reserves, might be used to advantage in improving physical performance.

2009 Munitions Executive Summit

DTIC Science & Technology

2009-02-05

CURRENT OPERATIONS • Replenish stocks expended in operations • Build /Replenish War Reserve stocks • Modernize stocks in the process • Industrial Base...4 Steel-Consuming Markets Construction (40% - 45%) Appliances, Office Furniture (2.5%) Containers (4%) Industrial Equipment (15% - 18...Partnership - HPS for Bridges • U.S. Navy • FHWA • AISI Steel and Defense Industries Collaboration – High- Performance Steels 17 Major

Effects of landscape composition and configuration on migrating songbirds: inference from and individual-based model

Treesearch

Emily Cohen; Scott Pearson; Frank Moore

2014-01-01

The behavior of long-distance migrants during stopover is constrained by the need to quickly and safely replenish energetic reserves. Replenishing fuel stores at stopover sites requires adjusting to unfamiliar landscapes with little to no information about the distribution of resources. Despite their critical importance to the success of songbird migration, the effects...

Army Logistician. Volume 41, Issue 3, May-June 2009

DTIC Science & Technology

2009-06-01

analyzing, and executing multifunc- tional logistics, including transportation, food service, and acquisition, receipt, issue, and recovery of Govern...internal gun truck security for presence patrols, com- bat replenishment operations, recovery operations for damaged vehicles, or escort operations for...the next mission. During our 14-month deployment, the gun truck pla- toon provided security for 208 combat replenishment operations, 27 recovery

Finite horizon EOQ model for non-instantaneous deteriorating items with price and advertisement dependent demand and partial backlogging under inflation

NASA Astrophysics Data System (ADS)

Palanivel, M.; Uthayakumar, R.

2015-07-01

This paper deals with an economic order quantity (EOQ) model for non-instantaneous deteriorating items with price and advertisement dependent demand pattern under the effect of inflation and time value of money over a finite planning horizon. In this model, shortages are allowed and partially backlogged. The backlogging rate is dependent on the waiting time for the next replenishment. This paper aids the retailer in minimising the total inventory cost by finding the optimal interval and the optimal order quantity. An algorithm is designed to find the optimum solution of the proposed model. Numerical examples are given to demonstrate the results. Also, the effect of changes in the different parameters on the optimal total cost is graphically presented and the implications are discussed in detail.

Annual replenishment of bed material by sediment transport in the Wind River near Riverton, Wyoming

USGS Publications Warehouse

Smalley, M.L.; Emmett, W.W.; Wacker, A.M.

1994-01-01

The U.S. Geological Survey, in cooperation with the Wyoming Department of Transportation, conducted a study during 1985-87 to determine the annual replenishment of sand and gravel along a point bar in the Wind River near Riverton, Wyoming. Hydraulic- geometry relations determined from streamflow measurements; streamflow characteristics determined from 45 years of record at the study site; and analyses of suspended-sediment, bedload, and bed- material samples were used to describe river transport characteristics and to estimate the annual replenishment of sand and gravel. The Wind River is a perennial, snowmelt-fed stream. Average daily discharge at the study site is about 734 cubic feet per second, and bankfull discharge (recurrence interval about 1.5 years) is about 5,000 cubic feet per second. At bankfull discharge, the river is about 136 feet wide and has an average depth of about 5.5 feet and average velocity of about 6.7 feet per second. Streams slope is about 0.0010 foot per foot. Bed material sampled on the point bar before the 1986 high flows ranged from sand to cobbles, with a median diameter of about 22 millimeters. Data for sediment samples collected during water year 1986 were used to develop regression equations between suspended-sediment load and water discharge and between bedload and water discharge. Average annual suspended-sediment load was computed to be about 561,000 tons per year using the regression equation in combination with flow-duration data. The regression equation for estimating bedload was not used; instead, average annual bedload was computed as 1.5 percent of average annual suspended load about 8,410 tons per year. This amount of bedload material is estimated to be in temporary storage along a reach containing seven riffles--a length of approximately 1 river mile. On the basis of bedload material sampled during the 1986 high flows, about 75 percent (by weight) is sand (2 millimeters in diameter or finer); median particle size is about 0.5 milli- meter. About 20 percent (by weight) is medium gravel to small cobbles--12.7 millimeters (0.5 inch) or coarser. The bedload moves slowly (about 0.03 percent of the water speed) and briefly (about 10 percent of the time). The average travel distance of a median-sized particle is about 1 river mile per year. The study results indicate that the average replenishment rate of bedload material coarser than 12.7 millimeters is about 1,500 to 2,000 tons (less than 1,500 cubic yards) per year. Finer material (0.075 to 6.4 millimeters in diameter) is replen- ishment at about 4,500 to 5,000 cubic yards per year. The total volume of potentially usable material would average about 6,000 cubic yards per year.

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

PubMed

Ryu, Dongryeol; Zhang, Hongbo; Ropelle, Eduardo R; Sorrentino, Vincenzo; Mázala, Davi A G; Mouchiroud, Laurent; Marshall, Philip L; Campbell, Matthew D; Ali, Amir Safi; Knowels, Gary M; Bellemin, Stéphanie; Iyer, Shama R; Wang, Xu; Gariani, Karim; Sauve, Anthony A; Cantó, Carles; Conley, Kevin E; Walter, Ludivine; Lovering, Richard M; Chin, Eva R; Jasmin, Bernard J; Marcinek, David J; Menzies, Keir J; Auwerx, Johan

2016-10-19

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and nicotinamide adenine dinucleotide (NAD + ) synthesis, consistent with a potential role for the essential cofactor NAD + in protecting muscle from metabolic and structural degeneration. Furthermore, the skeletal muscle transcriptomes of patients with Duchene's muscular dystrophy (DMD) and other muscle diseases were enriched for various poly[adenosine 5'-diphosphate (ADP)-ribose] polymerases (PARPs) and for nicotinamide N-methyltransferase (NNMT), enzymes that are major consumers of NAD + and are involved in pleiotropic events, including inflammation. In the mdx mouse model of DMD, we observed significant reductions in muscle NAD + levels, concurrent increases in PARP activity, and reduced expression of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD + biosynthesis. Replenishing NAD + stores with dietary nicotinamide riboside supplementation improved muscle function and heart pathology in mdx and mdx/Utr -/- mice and reversed pathology in Caenorhabditis elegans models of DMD. The effects of NAD + repletion in mdx mice relied on the improvement in mitochondrial function and structural protein expression (α-dystrobrevin and δ-sarcoglycan) and on the reductions in general poly(ADP)-ribosylation, inflammation, and fibrosis. In combination, these studies suggest that the replenishment of NAD + may benefit patients with muscular dystrophies or other neuromuscular degenerative conditions characterized by the PARP/NNMT gene expression signatures. Copyright © 2016, American Association for the Advancement of Science.

Synchronization of construction, replenishment and leasing cycles with account of wave dynamics of innovation cycles in the construction and transport field

NASA Astrophysics Data System (ADS)

Alekseeva, Tatyana

2017-10-01

The article considers the contradictive nature of the basic cycles of the growth in construction, the core of which are construction cycles, replenishment cycles of the active part of fixed assets, innovation and investment cycles. All of the listed cycles objectively thwart the science and technology progress in construction. There are presented results of the study of finance leasing as an effective tool, that provides time reduction of the innovation replenishment cycle of the active part of fixed assets in construction. It takes into account the development and implementation terms of construction investment projects in order to timely support the innovation wave and enhance its efficiency in construction for a rapid transition of the construction investment complex and national economy to a new vector of growth.

Characterization of dopamine releasable and reserve pools in Drosophila larvae using ATP/P2X2-mediated stimulation

PubMed Central

Xiao, Ning; Venton, B. Jill

2015-01-01

Dopaminergic signaling pathways are conserved between mammals and Drosophila, but the factors important for maintaining the functional pool of synaptic dopamine are not fully understood in Drosophila. In this study, we characterized the releasable and reserve dopamine pools in Drosophila larvae using ATP/ P2X2-mediated stimulation. Dopamine release was stable with stimulations performed at least every 5 min but decayed with stimulations performed 2 min apart or less, indicating the replenishment of the releasable pool occurred on a time scale between 2 and 5 min. Dopamine synthesis or uptake were pharmacologically inhibited with 3-iodotyrosine and cocaine, respectively, to evaluate their contributions to maintaining the releasable dopamine pool. We found that both synthesis and uptake were needed to maintain the releasable dopamine pool, with synthesis playing a major part in long-term replenishment and uptake being more important for short-term replenishment. These effects of synthesis and uptake on different time scales in Drosophila are analogous to mammals. However, unlike in mammals, cocaine did not activate a reserve pool of dopamine in Drosophila when using P2X2 stimulations. Our study shows that both synthesis and uptake replenish the releasable pool, providing a better understanding of dopamine regulation in Drosophila. PMID:25951875

Transdermal Delivery of Iron Using Soluble Microneedles: Dermal Kinetics and Safety.

PubMed

Modepalli, Naresh; Shivakumar, H Nanjappa; McCrudden, Maeliosa T C; Donnelly, Ryan F; Banga, Ajay; Murthy, S Narasimha

2016-03-01

Currently, the iron compounds are administered via oral and parenteral routes in patients of all ages, to treat iron deficiency. Despite continued efforts to supplement iron via these conventional routes, iron deficiency still remains the most prevalent nutritional disorder all over the world. Transdermal replenishment of iron is a novel, potential approach of iron replenishment. Ferric pyrophosphate (FPP) was found to be a suitable source of iron for transdermal replenishment. The safety of FPP was assessed in this project by challenging the dermal fibroblast cells with high concentration of FPP. The cell viability assay and reactive oxygen species assay were performed. The soluble microneedle array was developed, incorporated with FPP and the kinetics of free iron in the skin; extracellular fluid following dermal administration of microneedle array was investigated in hairless rats. From the cell based assays, FPP was selected as one of the potential iron sources for transdermal delivery. The microneedles were found to dissolve in the skin fluid within 3 hours of administration. The FPP concentration in the dermal extracellular fluid declined after complete dissolution of the microneedle array. Overall, the studies demonstrated the safety of FPP for dermal delivery and the feasibility of soluble microneedle approach for transdermal iron replenishment therapy. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Generous-like flowers: nectar production in two epiphytic bromeliads and a meta-analysis of removal effects.

PubMed

Ordano, Mariano; Ornelas, Juan Francisco

2004-08-01

Animal-pollinated angiosperm plants that respond positively to nectar removal by replenishment invest energy that can entail a reproductive cost. We investigated whether or not nectar removal stimulates replenishment in two hummingbird-pollinated bromeliad species. Nectar replenishment rates were also assessed by removing nectar from manually pollinated flowers because pollination events might be used as signals to save energy by preventing allocation to post-pollination nectar production. Then we synthesized the current understanding of nectar removal effects by reviewing existing published studies with a meta-analysis. The magnitude and significance of estimated nectar removal effects and factors associated with variation in size and direction of nectar removal effects were elucidated with the meta-analysis. We found that both Tillandsia species strongly respond to repeated nectar removal by producing >3 times additional nectar. Nectar secretion patterns were not altered by pollination (stigmatic pollen deposition) and we found no evidence of nectar reabsorption. Although the effect size varied widely across systems and/or environmental conditions, the meta-analysis showed that nectar removal had overall a positive effect on nectar replenishment (mainly among species inhabiting wet tropical habitats such as Tillandsia), and a negative effect on the secretion of additional sugar, suggesting that those plants are resource limited and conservative in the secretion of additional sugar.

The role of the geothermal gradient in the emplacement and replenishment of ground ice on Mars

NASA Technical Reports Server (NTRS)

Clifford, Stephen M.

1993-01-01

Knowledge of the mechanisms by which ground ice is emplaced, removed, and potentially replenished, are critical to understanding the climatic and hydrologic behavior of water on Mars, as well as the morphologic evolution of its surface. Because of the strong temperature dependence of the saturated vapor pressure of H2O, the atmospheric emplacement or replenishment of ground ice is prohibited below the depth at which crustal temperatures begin to monotonically increase due to geothermal heating. In contrast, the emplacement and replenishment of ground ice from reservoirs of H2O residing deep within the crust can occur by at least three different thermally-driven processes, involving all three phases of water. In this regard, Clifford has discussed how the presence of a geothermal gradient as small as 15 K/km can give rise to a corresponding vapor pressure gradient sufficient to drive the vertical transport of 1 km of water from a reservoir of ground water at depth to the base of the cryosphere every 10(exp 6) - 10(exp 7) years. This abstract expands on this earlier treatment by considering the influence of thermal gradients on the transport of H2O at temperatures below the freezing point.

Planning for Follow-On Spare Part Support by the Naval Electronic Systems Command.

DTIC Science & Technology

1984-06-01

System Replenishment Spare Parts", by Edward J. Brost , Air Force Institute of Technology [17]_ The objective of this study was to determine the...Competition in the Acquisition of Replenishment Spare Parts, M.S. Thesis, Air Force Institute of Technology, WPAFB, Ohio, September 1983. 17. Brost ...Instruction 4000.6D, Integrated Logistic Support (ILS); policy and responsibilities. 21 July 1983. 20. Mr. George Hughes, NAVELEX Code 81234

Dengue virus replicates and accumulates in Aedes aegypti salivary glands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raquin, Vincent, E-mail: vincent.raquin@univ-lyon1

Dengue virus (DENV) is an RNA virus transmitted among humans by mosquito vectors, mainly Aedes aegypti. DENV transmission requires viral dissemination from the mosquito midgut to the salivary glands. During this process the virus undergoes several population bottlenecks, which are stochastic reductions in population size that restrict intra-host viral genetic diversity and limit the efficiency of natural selection. Despite the implications for virus transmission and evolution, DENV replication in salivary glands has not been directly demonstrated. Here, we used a strand-specific quantitative RT-PCR assay to demonstrate that negative-strand DENV RNA is produced in Ae. aegypti salivary glands, providing conclusive evidencemore » that viral replication occurs in this tissue. Furthermore, we showed that the concentration of DENV genomic RNA in salivary glands increases significantly over time, indicating that active replication likely replenishes DENV genetic diversity prior to transmission. These findings improve our understanding of the biological determinants of DENV fitness and evolution. - Highlights: •Strand-specific RT-qPCR allows accurate quantification of DENV (-) RNA in mosquito tissues. •Detection of DENV (-) RNA in salivary glands provides evidence of viral replication in this tissue. •Viral replication in salivary glands likely replenishes DENV genetic diversity prior to transmission.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howell, C; Vu, TL; Lin, JJ

Inspired by the long-term effectiveness of living antifouling materials, we have developed a method for the self-replenishment of synthetic biofouling-release surfaces. These surfaces are created by either molding or directly embedding 3D vascular systems into polydimethylsiloxane (PDMS) and filling them with a silicone oil to generate a nontoxic oil-infused material. When replenished with silicone oil from an outside source, these materials are capable of self-lubrication and continuous renewal of the interfacial fouling-release layer. Under accelerated lubricant loss conditions, fully infused vascularized samples retained significantly more lubricant than equivalent nonvascularized controls. Tests of lubricant-infused PDMS in static cultures of the infectiousmore » bacteria Staphylococcus aureus and Escherichia coli as well as the green microalgae Botryococcus braunii, Chlamydomonas reinhardtii, Dunaliella sauna, and Nannochloropsis oculata showed a significant reduction in biofilm adhesion compared to PDMS and glass controls containing no lubricant. Further experiments on vascularized versus nonvascularized samples that had been subjected to accelerated lubricant evaporation conditions for up to 48 h showed significantly less biofilm adherence on the vascularized surfaces. These results demonstrate the ability of an embedded lubricant-filled vascular network to improve the longevity of fouling-release surfaces.« less

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment

PubMed Central

Zhou, Minghai; Ottenberg, Gregory; Sferrazza, Gian Franco; Hubbs, Christopher; Fallahi, Mohammad; Rumbaugh, Gavin; Brantley, Alicia F.

2015-01-01

The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such as Alzheimer’s, Parkinson’s and prion diseases are poorly understood. We used a highly toxic misfolded prion protein (TPrP) model to understand neurotoxicity induced by prion protein misfolding. We show that abnormal autophagy activation and neuronal demise is due to severe, neuron-specific, nicotinamide adenine dinucleotide (NAD+) depletion. Toxic prion protein-exposed neuronal cells exhibit dramatic reductions of intracellular NAD+ followed by decreased ATP production, and are completely rescued by treatment with NAD+ or its precursor nicotinamide because of restoration of physiological NAD+ levels. Toxic prion protein-induced NAD+ depletion results from PARP1-independent excessive protein ADP-ribosylations. In vivo, toxic prion protein-induced degeneration of hippocampal neurons is prevented dose-dependently by intracerebral injection of NAD+. Intranasal NAD+ treatment of prion-infected sick mice significantly improves activity and delays motor impairment. Our study reveals NAD+ starvation as a novel mechanism of autophagy activation and neurodegeneration induced by a misfolded amyloidogenic protein. We propose the development of NAD+ replenishment strategies for neuroprotection in prion diseases and possibly other protein misfolding neurodegenerative diseases. PMID:25678560

Self-Replenishing Vascularized Fouling-Release Surfaces

DOE PAGES

Howell, Caitlin; Vu, Thy L.; Lin, Jennifer J.; ...

2014-08-13

Inspired by the long-term effectiveness of living antifouling materials, we have developed a method for the selfreplenishment of synthetic biofouling-release surfaces. These surfaces are created by either molding or directly embedding 3D vascular systems into polydimethylsiloxane (PDMS) and filling them with a silicone oil to generate a nontoxic oil-infused material. When replenished with silicone oil from an outside source, these materials are capable of self-lubrication and continuous renewal of the interfacial fouling-release layer. Under accelerated lubricant loss conditions, fully infused vascularized samples retained significantly more lubricant than equivalent nonvascularized controls. Tests of lubricant-infused PDMS in static cultures of the infectiousmore » bacteria Staphylococcus aureus and Escherichia coli as well as the green microalgae Botryococcus braunii, Chlamydomonas reinhardtii, Dunaliella salina, and Nannochloropsis oculata showed a significant reduction in biofilm adhesion compared to PDMS and glass controls containing no lubricant. Further experiments on vascularized versus nonvascularized samples that had been subjected to accelerated lubricant evaporation conditions for up to 48 h showed significantly less biofilm adherence on the vascularized surfaces. These results demonstrate the ability of an embedded lubricant-filled vascular network to improve the longevity of fouling-release surfaces.« less

Cerebellar Granule Cell Replenishment Post-Injury by Adaptive Reprogramming of Nestin+ Progenitors

PubMed Central

Wojcinski, Alexandre; Lawton, Andrew K.; Bayin, N Sumru.; Lao, Zhimin; Stephen, Daniel N.; Joyner, Alexandra L.

2017-01-01

Regeneration of several organs involves adaptive reprogramming of progenitors, however, the intrinsic capacity of the developing brain to replenish lost cells remains largely unknown. In this study, we discovered that the developing cerebellum has unappreciated progenitor plasticity, since it undergoes near full growth and functional recovery following acute depletion of granule cells, the most plentiful neuron population in the brain. We demonstrate that following postnatal ablation of granule cell progenitors, Nestin-expressing progenitors (NEPs) specified during mid-embryogenesis to produce astroglia and interneurons, switch their fate and generate granule neurons in mice. Moreover, Hedgehog-signaling in two NEP populations is crucial not only for the compensatory replenishment of granule neurons but also to scale interneuron and astrocyte numbers. Thus we provide insights into the mechanisms underlying robustness of circuit formation in the cerebellum, and speculate that adaptive reprogramming of progenitors in other brain regions plays a greater role than appreciated in developmental regeneration. PMID:28805814

Study of communications data compression methods

NASA Technical Reports Server (NTRS)

Jones, H. W.

1978-01-01

A simple monochrome conditional replenishment system was extended to higher compression and to higher motion levels, by incorporating spatially adaptive quantizers and field repeating. Conditional replenishment combines intraframe and interframe compression, and both areas are investigated. The gain of conditional replenishment depends on the fraction of the image changing, since only changed parts of the image need to be transmitted. If the transmission rate is set so that only one fourth of the image can be transmitted in each field, greater change fractions will overload the system. A computer simulation was prepared which incorporated (1) field repeat of changes, (2) a variable change threshold, (3) frame repeat for high change, and (4) two mode, variable rate Hadamard intraframe quantizers. The field repeat gives 2:1 compression in moving areas without noticeable degradation. Variable change threshold allows some flexibility in dealing with varying change rates, but the threshold variation must be limited for acceptable performance.

Source replenishment device for vacuum deposition

DOEpatents

Hill, Ronald A.

1988-01-01

A material source replenishment device for use with a vacuum deposition apparatus. The source replenishment device comprises an intermittent motion producing gear arrangement disposed within the vacuum deposition chamber. An elongated rod having one end operably connected to the gearing arrangement is provided with a multiarmed head at the opposite end disposed adjacent the heating element of the vacuum deposition apparatus. An inverted U-shaped source material element is releasably attached to the outer end of each arm member whereby said multiarmed head is moved to locate a first of said material elements above said heating element, whereupon said multiarmed head is lowered to engage said material element with the heating element and further lowered to release said material element on the heating element. After vaporization of said material element, second and subsequent material elements may be provided to the heating element without the need for opening the vacuum deposition apparatus to the atmosphere.

Source replenishment device for vacuum deposition

DOEpatents

Hill, R.A.

1986-05-15

A material source replenishment device for use with a vacuum deposition apparatus is described. The source replenishment device comprises an intermittent motion producing gear arrangement disposed within the vacuum deposition chamber. An elongated rod having one end operably connected to the gearing arrangement is provided with a multiarmed head at the opposite end disposed adjacent the heating element of the vacuum deposition apparatus. An inverted U-shaped source material element is releasably attached to the outer end of each arm member whereby said multiarmed head is moved to locate a first of said material elements above said heating element, whereupon said multiarmed head is lowered to engage said material element with the heating element and further lowered to release said material element on the heating element. After vaporization of said material element, second and subsequent material elements may be provided to the heating element without the need for opening the vacuum deposition apparatus to the atmosphere.

Stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit in Jaworzno III Power Plant - Power Plant II

NASA Astrophysics Data System (ADS)

Karpiński, Marcin; Kmiecik, Ewa

2017-11-01

In Poland, electricity is still produced mainly in conventional power plants where fuel and water are materials necessary to generate the electricity. Even in modern power plants operating according to the principles of the sustainable development, this involves a high intake of water and considerable production of wastewater. This, in turn, necessi-tates the application of some technological solutions aimed at limiting the negative impact on the environment. The Jaworzno III Power Plant - Power Plant II is located in Jaworzno, Silesian Province, Poland. In order to minimise the negative impact on the surface water, the plant replenishes the cooling circuit with the mining water obtained from the closed-down Jan Kanty mine. The paper presents a stability assessment of the chemical composition of the treated mining water used to replenish the cooling circuit based on the data from 2007-2017.

Development of processes for the production of low cost silicon dendritic web for solar cells

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Seidensticker, R. G.; Mchugh, J. P.; Hopkins, R. H.; Skutch, M. E.; Driggers, J. M.; Hill, F. E.

1980-01-01

High area output rates and continuous, automated growth are two key technical requirements for the growth of low-cost silicon ribbons for solar cells. By means of computer-aided furnace design, silicon dendritic web output rates as high as 27 sq cm/min have been achieved, a value in excess of that projected to meet a $0.50 per peak watt solar array manufacturing cost. The feasibility of simultaneous web growth while the melt is replenished with pelletized silicon has also been demonstrated. This step is an important precursor to the development of an automated growth system. Solar cells made on the replenished material were just as efficient as devices fabricated on typical webs grown without replenishment. Moreover, web cells made on a less-refined, pelletized polycrystalline silicon synthesized by the Battelle process yielded efficiencies up to 13% (AM1).

Replenishing data descriptors in a DMA injection FIFO buffer

DOEpatents

Archer, Charles J [Rochester, MN; Blocksome, Michael A [Rochester, MN; Cernohous, Bob R [Rochester, MN; Heidelberger, Philip [Cortlandt Manor, NY; Kumar, Sameer [White Plains, NY; Parker, Jeffrey J [Rochester, MN

2011-10-11

Methods, apparatus, and products are disclosed for replenishing data descriptors in a Direct Memory Access (`DMA`) injection first-in-first-out (`FIFO`) buffer that include: determining, by a messaging module on an origin compute node, whether a number of data descriptors in a DMA injection FIFO buffer exceeds a predetermined threshold, each data descriptor specifying an application message for transmission to a target compute node; queuing, by the messaging module, a plurality of new data descriptors in a pending descriptor queue if the number of the data descriptors in the DMA injection FIFO buffer exceeds the predetermined threshold; establishing, by the messaging module, interrupt criteria that specify when to replenish the injection FIFO buffer with the plurality of new data descriptors in the pending descriptor queue; and injecting, by the messaging module, the plurality of new data descriptors into the injection FIFO buffer in dependence upon the interrupt criteria.

Cyclic variations in nitrogen uptake rate of soybean plants: effects of pH and mixed nitrogen sources

NASA Technical Reports Server (NTRS)

Raper, C. D. Jr; Vessey, J. K.; Henry, L. T.; Chaillou, S.

1991-01-01

To determine if the daily pattern of NO3- and NH4+ uptake is affected by acidity or NO3- : NH4+ ratio of the nutrient solution, non-nodulated soybean plants (Glycine max) were exposed for 21 days to replenished, complete nutrient solutions at pH 6.0, 5.5, 5.0, and 4.5 which contained either 1.0 mM NH4+, 1.0 mM NO3- [correction of NO3+], 0.67 mM NH4+ plus 0.33 mM NO3- (2:1 NH4+ : NO3-) [correction of (2:1 NH3+ : NO4-)], or 0.33 mM NH4+ plus 0.67 mM NO3- (1:2 NH4+ : NO3-). Net uptake rates of NH4+ and NO3- were measured daily by ion chromatography as depletion from the replenished solutions. When NH4+ and NO3- were supplied together, cumulative uptake of total nitrogen was not affected by pH or solution NH4+ : NO3- ratio. The cumulative proportion of nitrogen absorbed as NH4+ decreased with increasing acidity; however, the proportional uptake of NH4+ and NO3- was not constant, but varied day-to-day. This day-to-day variation in relative proportions of NH4+ and NO3- absorbed when NH4+ : NO3- ratio and pH of solution were constant indicates that the regulatory mechanism is not directly competitive. Regardless of the effect of pH on cumulative uptake of NH4+, the specific nitrogen uptake rates from mixed and from individual NH4+ and NO3- sources oscillated between maxima and minima at each pH with average periodicities similar to the expected interval of leaf emergence.

Real time myocardial contrast echocardiography during supine bicycle stress and continuous infusion of contrast agent. Cutoff values for myocardial contrast replenishment discriminating abnormal myocardial perfusion.

PubMed

Miszalski-Jamka, Tomasz; Kuntz-Hehner, Stefanie; Schmidt, Harald; Hammerstingl, Christoph; Tiemann, Klaus; Ghanem, Alexander; Troatz, Clemens; Lüderitz, Berndt; Omran, Heyder

2007-07-01

Myocardial contrast echocardiography (MCE) is a new imaging modality for diagnosing coronary artery disease (CAD). The aim of our study was to evaluate feasibility of qualitative myocardial contrast replenishment (RP) assessment during supine bicycle stress MCE and find out cutoff values for such analysis, which could allow accurate detection of CAD. Forty-four consecutive patients, scheduled for coronary angiography (CA) underwent supine bicycle stress two-dimensional echocardiography (2DE). During the same session, MCE was performed at peak stress and post stress. Ultrasound contrast agent (SonoVue) was administered in continuous mode using an infusion pump (BR-INF 100, Bracco Research). Seventeen-segment model of left ventricle was used in analysis. MCE was assessed off-line in terms of myocardial contrast opacification and RP. RP was evaluated on the basis of the number of cardiac cycles required to refill the segment with contrast after its prior destruction with high-power frames. Determination of cutoff values for RP assessment was performed by means of reference intervals and receiver operating characteristic analysis. Quantitative CA was carried out using CAAS system. MCE could be assessed in 42 patients. CA revealed CAD in 25 patients. Calculated cutoff values for RP-analysis (peak-stress RP >3 cardiac cycles and difference between peak stress and post stress RP >0 cardiac cycles) provided sensitive (88%) and accurate (88%) detection of CAD. Sensitivity and accuracy of 2DE were 76% and 79%, respectively. Qualitative RP-analysis based on the number of cardiac cycles required to refill myocardium with contrast is feasible during supine bicycle stress MCE and enables accurate detection of CAD.

Attitudes and opinions of nursing and medical staff regarding the supply and storage of medicinal products before and after the installation of a drawer-based automated stock-control system.

PubMed

Ardern-Jones, Joanne; Hughes, Donald K; Rowe, Philip H; Mottram, David R; Green, Christopher F

2009-04-01

This study assessed the attitudes of Emergency Department (ED) staff regarding the introduction of an automated stock-control system. The objectives were to determine attitudes to stock control and replenishment, speed of access to the system, ease of use and the potential for future uses of the system. The study was carried out in the Countess of Chester Hospital NHS Foundation Trust (COCH) ED, which is attended by over 65,000 patients each year. All 68 ED staff were sent pre-piloted, semi-structured questionnaires and reminders, before and after automation of medicines stock control. Pre-implementation, 35 staff (66.1% of respondents) reported that problems occurred with access to medicine storage keys 'very frequently' or 'frequently'. Twenty-eight (52.8%) respondents 'agreed' or 'strongly agreed' that medicines were quickly accessed, which rose to 41 (77%) post-automation (P < 0.001). Improvement was reported in stock replenishment and storage of stock injections and oral medicines, but there were mixed opinions regarding storage of bulk fluids and refrigerated items. Twenty-seven (51.9%) staff reported access to the system within 1 min and 17 (32.7%) staff reported access within 1-2 min. The majority of staff found the system 'easy' or 'very easy' to use and there was a non-significant relationship between previous use of information technology and acceptance of the system. From a staff satisfaction perspective, automation improved medicines storage, security and stock control, and addressed the problem of searching for keys to storage areas. Concerns over familiarity with computers, queuing, speed of access and an improved audit trail do not appear to have been issues, when compared with the previous manual storage of medicines.

Self-replenishing ability of cross-linked low surface energy polymer films investigated by a complementary experimental-simulation approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Esteves, A. C. C., E-mail: a.c.c.esteves@tue.nl, E-mail: g.dewith@tue.nl; Lyakhova, K.; Riel, J. M. van

2014-03-28

Nowadays, many self-healing strategies are available for recovering mechanical damage of bulk polymeric materials. The recovery of surface-dependent functionalities on polymer films is, however, equally important and has been less investigated. In this work we study the ability of low surface energy cross-linked poly(ester urethane) networks containing perfluorinated dangling chains to self-replenish their surface, after being submitted to repeated surface damage. For this purpose we used a combined experimental-simulation approach. Experimentally, the cross-linked films were intentionally damaged by cryo-microtoming to remove top layers and create new surfaces which were characterized by water Contact Angle measurements and X-Ray Photoelectron Spectroscopy. Themore » same systems were simultaneously represented by a Dissipative Particles Dynamics simulation method, where the damage was modeled by removing the top film layers in the simulation box and replacing it by new “air” beads. The influence of different experimental parameters, such as the concentration of the low surface energy component and the molecular mobility span of the dangling chains, on the surface recovery is discussed. The combined approach reveals important details of the self-replenishing ability of damaged polymer films such as the occurrence of multiple-healing events, the self-replenishing efficiency, and the minimum “healing agent” concentration for a maximum recovery.« less

NAD+ : A big player in cardiac and skeletal muscle remodeling and aging.

PubMed

Chaturvedi, Pankaj; Tyagi, Suresh C

2018-03-01

In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and anti-aging molecule. A paper in science by Zhang et al. () has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al. () demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al. () also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure. Although NAD+ has a profound anti-aging and anti-oxidant effects, its effect on humans and use as a dietary supplement needs more exploration. © 2017 Wiley Periodicals, Inc.

Using a cloud to replenish parched groundwater modeling efforts.

PubMed

Hunt, Randall J; Luchette, Joseph; Schreuder, Willem A; Rumbaugh, James O; Doherty, John; Tonkin, Matthew J; Rumbaugh, Douglas B

2010-01-01

Groundwater models can be improved by introduction of additional parameter flexibility and simultaneous use of soft-knowledge. However, these sophisticated approaches have high computational requirements. Cloud computing provides unprecedented access to computing power via the Internet to facilitate the use of these techniques. A modeler can create, launch, and terminate "virtual" computers as needed, paying by the hour, and save machine images for future use. Such cost-effective and flexible computing power empowers groundwater modelers to routinely perform model calibration and uncertainty analysis in ways not previously possible.

Using a cloud to replenish parched groundwater modeling efforts

USGS Publications Warehouse

Hunt, Randall J.; Luchette, Joseph; Schreuder, Willem A.; Rumbaugh, James O.; Doherty, John; Tonkin, Matthew J.; Rumbaugh, Douglas B.

2010-01-01

Groundwater models can be improved by introduction of additional parameter flexibility and simultaneous use of soft-knowledge. However, these sophisticated approaches have high computational requirements. Cloud computing provides unprecedented access to computing power via the Internet to facilitate the use of these techniques. A modeler can create, launch, and terminate “virtual” computers as needed, paying by the hour, and save machine images for future use. Such cost-effective and flexible computing power empowers groundwater modelers to routinely perform model calibration and uncertainty analysis in ways not previously possible.

The combined effects of forward masking by noise and high click rate on monaural and binaural human auditory nerve and brainstem potentials.

PubMed

Pratt, Hillel; Polyakov, Andrey; Bleich, Naomi; Mittelman, Naomi

2004-07-01

To study effects of forward masking and rapid stimulation on human monaurally- and binaurally-evoked brainstem potentials and suggest their relation to synaptic fatigue and recovery and to neuronal action potential refractoriness. Auditory brainstem evoked potentials (ABEPs) were recorded from 12 normally- and symmetrically hearing adults, in response to each click (50 dB nHL, condensation and rarefaction) in a train of nine, with an inter-click interval of 11 ms, that followed a white noise burst of 100 ms duration (50 dB nHL). Sequences of white noise and click train were repeated at a rate of 2.89 s(-1). The interval between noise and first click in the train was 2, 11, 22, 44, 66 or 88 ms in different runs. ABEPs were averaged (8000 repetitions) using a dwell time of 25 micros/address/channel. The binaural interaction components (BICs) of ABEPs were derived and the single, centrally located equivalent dipoles of ABEP waves I and V and of the BIC major wave were estimated. The latencies of dipoles I and V of ABEP, their inter-dipole interval and the dipole magnitude of component V were significantly affected by the interval between noise and clicks and by the serial position of the click in the train. The latency and dipole magnitude of the major BIC component were significantly affected by the interval between noise and clicks. Interval from noise and the click's serial position in the train interacted to affect dipole V latency, dipole V magnitude, BIC latencies and the V-I inter-dipole latency difference. Most of the effects were fully apparent by the first few clicks in the train, and the trend (increase or decrease) was affected by the interval between noise and clicks. The changes in latency and magnitude of ABEP and BIC components with advancing position in the click train and the interactions of click position in the train with the intervals from noise indicate an interaction of fatigue and recovery, compatible with synaptic depletion and replenishing, respectively. With the 2 ms interval between noise and the first click in the train, neuronal action potential refractoriness may also be involved.

Mixed sand and gravel beaches: accurate measurement of active layer depth and sediment transport volumes using PIT tagged tracer pebbles

NASA Astrophysics Data System (ADS)

Holland, A.; Moses, C.; Sear, D. A.; Cope, S.

2016-12-01

As sediments containing significant gravel portions are increasingly used for beach replenishment projects globally, the total number of beaches classified as `mixed sand and gravel' (MSG) increases. Calculations for required replenishment sediment volumes usually assume a uniform layer of sediment transport across and along the beach, but research into active layer (AL) depth has shown variations both across shore and according to sediment size distribution. This study addresses the need for more accurate calculations of sediment transport volumes on MSG beaches by using more precise measurements of AL depth and width, and virtual velocity of tracer pebbles. Variations in AL depth were measured along three main profile lines (from MHWS to MLWN) at Eastoke, Hayling Island (Hampshire, UK). Passive Integrated Transponder (PIT) tagged pebbles were deployed in columns, and their new locations repeatedly surveyed with RFID technology. These data were combined with daily dGPS beach profiles and sediment sampling for detailed analysis of the influence of beach morphodynamics on sediment transport volumes. Data were collected over two consecutive winter seasons: 2014-15 (relatively calm, average wave height <1 m) and 2015-16 (prolonged periods of moderate storminess, wave heights of 1-2 m). The active layer was, on average, 22% of wave height where beach slope (tanβ) is 0.1, with variations noted according to slope angle, sediment distribution, and beach groundwater level. High groundwater levels and a change in sediment proportions in the sandy lower foreshore reduced the AL to 10% of wave height in this area. The disparity in AL depth across the beach profile indicates that traditional models are not accurately representing bulk sediment transport on MSG beaches. It is anticipated that by improving model inputs, beach managers will be better able to predict necessary volumes and sediment grain size proportions of replenishment material for effective management of MSG beaches.

A randomized clinical trial in vitamin D-deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood.

PubMed

Ponda, Manish P; Liang, Yupu; Kim, Jaehwan; Hutt, Richard; Dowd, Kathleen; Gilleaudeau, Patricia; Sullivan-Whalen, Mary M; Rodrick, Tori; Kim, Dong Joo; Barash, Irina; Lowes, Michelle A; Breslow, Jan L

2017-05-01

Background: Vitamin D deficiency, defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration <20 ng/mL, is correlated with a more atherogenic lipid profile. However, oral vitamin D supplementation does not lower LDL-cholesterol concentrations or raise HDL-cholesterol concentrations. This uncoupling between association and causation may result from a failure of oral vitamin D to mimic the effect of dermally synthesized vitamin D in response to ultraviolet type B (UVB) light. Objective: We tested the hypothesis that, in vitamin D-deficient adults, the replenishment of vitamin D with UVB exposure would lower LDL-cholesterol concentrations compared with the effect of oral vitamin D 3 supplementation. Design: We performed a randomized clinical trial in vitamin D-deficient adults and compared vitamin D replenishment between subjects who received oral vitamin D 3 ( n = 60) and those who received narrow-band UVB exposure ( n = 58) ≤6 mo. Results: There was no difference in the change from baseline LDL-cholesterol concentrations between oral vitamin D 3 and UVB groups (difference in median of oral vitamin D 3 minus that of UVB: 1.5 mg/dL; 95% CI: -5.0, 7.0 mg/dL). There were also no differences within groups or between groups for changes in total or HDL cholesterol or triglycerides. Transcriptional profiling of skin and blood, however, revealed significant upregulation of immune pathway signaling with oral vitamin D 3 but significant downregulation with UVB. Conclusions: Correcting vitamin D deficiency with either oral vitamin D 3 or UVB does not improve the lipid profile. Beyond cholesterol, these 2 modalities of raising 25(OH)D have disparate effects on gene transcription. This trial was registered at clinicaltrials.gov as NCT01688102. © 2017 American Society for Nutrition.

Advanced Czochralski silicon growth technology for photovoltaic modules

NASA Technical Reports Server (NTRS)

Daud, T.; Kachare, A. H.

1982-01-01

Several economic analyses had indicated that large-diameter, multiple ingot growth using a single crucible with melt replenishment would be required for Cz growth to be economically viable. Based on the results of these analyses, two liquid and two solid feed melt replenishment approaches were initiated. The sequential solid feed melt replenishment approach, which demonstrated elements of technical feasibility is described in detail in this paper. Growth results of multiple ingots (10-cm-diameter, totaling 100 kg; and 15-cm-diameter, totaling 150 kg weight per crucible) are presented. Solar cells were fabricated and analyzed to evaluate the effects of structure and chemical purities as a result of multiple growth. The results indicate that, with semiconductor-grade silicon, feedstock impurity build-up does not seem to degrade cell performance. For polycrystalline cells, the average efficiencies are 15 to 25% lower than those of single crystalline cells. Concerns regarding single crystal yields, crucible quality and growth speed are indicated, and present status and future research thrusts are also discussed.

Relationship between starch and lipid accumulation induced by nutrient depletion and replenishment in the microalga Parachlorella kessleri.

PubMed

Fernandes, Bruno; Teixeira, José; Dragone, Giuliano; Vicente, António A; Kawano, Shigeyuki; Bišová, Kateřina; Přibyl, Pavel; Zachleder, Vilém; Vítová, Milada

2013-09-01

Photosynthetic carbon partitioning into starch and neutral lipids, as well as the influence of nutrient depletion and replenishment on growth, pigments and storage compounds, were studied in the microalga, Parachlorella kessleri. Starch was utilized as a primary carbon and energy storage compound, but nutrient depletion drove the microalgae to channel fixed carbon into lipids as secondary storage compounds. Nutrient depletion inhibited both cellular division and growth and caused degradation of chlorophyll. Starch content decreased from an initial value of 25, to around 10% of dry weight (DW), while storage lipids increased from almost 0 to about 29% of DW. After transfer of cells into replenished mineral medium, growth, reproductive processes and chlorophyll content recovered within 2 days, while the content of both starch and lipids decreased markedly to 3 or less % of DW; this suggested that they were being used as a source of energy and carbon. Copyright © 2013 Elsevier Ltd. All rights reserved.

Optimizing Multi-Product Multi-Constraint Inventory Control Systems with Stochastic Replenishments

NASA Astrophysics Data System (ADS)

Allah Taleizadeh, Ata; Aryanezhad, Mir-Bahador; Niaki, Seyed Taghi Akhavan

Multi-periodic inventory control problems are mainly studied employing two assumptions. The first is the continuous review, where depending on the inventory level orders can happen at any time and the other is the periodic review, where orders can only happen at the beginning of each period. In this study, we relax these assumptions and assume that the periodic replenishments are stochastic in nature. Furthermore, we assume that the periods between two replenishments are independent and identically random variables. For the problem at hand, the decision variables are of integer-type and there are two kinds of space and service level constraints for each product. We develop a model of the problem in which a combination of back-order and lost-sales are considered for the shortages. Then, we show that the model is of an integer-nonlinear-programming type and in order to solve it, a search algorithm can be utilized. We employ a simulated annealing approach and provide a numerical example to demonstrate the applicability of the proposed methodology.

Long-term environmental impacts of building composites containing waste materials: Evaluation of the leaching protocols.

PubMed

Drinčić, Ana; Nikolić, Irena; Zuliani, Tea; Milačič, Radmila; Ščančar, Janez

2017-01-01

The NEN 7375 test has been proposed for evaluating the long-term environmental impacts caused by the release of contaminants from monolithic building and waste materials. Over a period of 64days, at specific points in time, the leaching solution (demineralised water) is replenished. By applying the NEN 7375 test, leaching of contaminants that is based mainly on diffusion is followed. In the present work, the results from modified leaching protocols were evaluated against those obtained by NEN 7375 test. In modified protocols, synthetic sea, surface and MilliQ water were used for the leaching of selected elements and chromate, molybdate and vanadate from compact and ground building composites (98% mixture of fly ash (80%) and cement (20%), and 2% of electric arc furnace (EAF) dust) over 6months. The leaching solutions were not replenished, imitating both the diffusion and the dissolution of contaminants. The data revealed larger extent of leaching when the leaching solution was not replenished. More extensive was also leaching from ground composites, which simulated the disintegration of the material over time. The composition of the leaching solution influenced the release of the matrix constituents from the composites and, consequently, the amount of elements and their chemical species. Synthetic sea and surface water used as leaching solutions, without replenishing, were found to be suitable to simulate the conditions when the building material is immersed in stagnant environmental waters. Copyright © 2016 Elsevier Ltd. All rights reserved.

Application of allflex conservation buffer in illumina genotyping.

PubMed

de Groot, M; Ras, T; van Haeringen, W A

2016-12-01

This experiment was designed to study if liquid conservation buffer used in the novel Tissue Sampling Technology (TST) from Allflex can be used for Illumina BeadChip genotyping. Ear punches were collected from 6 bovine samples, using both the Tissue Sampling Unit (TSU) as well as the Total Tagger Universal (TTU) collection system. The stability of the liquid conservation buffer was tested by genotyping samples on Illumina BeadChips, incubated at 0, 3, 15, 24, 48, 72, 168, 336, 720 h after sample collection. Additionally, a replenishment study was designed to test how often the liquid conservation buffer could be completely replenished before a significant call rate drop could be observed. Results from the stability study showed an average call rate of 0.993 for samples collected with the TSU system and 0.953 for samples collected with the TTU system, both exceeding the inclusion threshold call rate of 0.85. As an additional control, the identity of the individual animals was confirmed using the International Society of Animal Genetics (ISAG) recommended SNP panel. The replenishment study revealed a slight drop in the sample call rate after replenishing the conservation buffer for the fourth time for the TSU as well as the TTU samples. In routine analysis, this application allows for multiple experiments to be performed on the liquid conservation buffer, while maintaining the tissue samples for future use. The data collected in this study shows that the liquid conservation buffer used in the TST system can be used for Illumina BeadChip genotyping applications.

Predaceous ants, beach replenishment, and nest placement by sea turtles.

PubMed

Wetterer, James K; Wood, Lawrence D; Johnson, Chris; Krahe, Holly; Fitchett, Stephanie

2007-10-01

Ants known for attacking and killing hatchling birds and reptiles include the red imported fire ant (Solenopsis invicta Buren), tropical fire ant [Solenopsis geminata (Fabr.)], and little fire ant [Wasmannia auropunctata (Roger)]. We tested whether sea turtle nest placement influenced exposure to predaceous ants. In 2000 and 2001, we surveyed ants along a Florida beach where green turtles (Chelonia mydas L.), leatherbacks (Dermochelys coriacea Vandelli), and loggerheads (Caretta caretta L.) nest. Part of the beach was artificially replenished between our two surveys. As a result, mean beach width experienced by nesting turtles differed greatly between the two nesting seasons. We surveyed 1,548 sea turtle nests (2000: 909 nests; 2001: 639 nests) and found 22 ant species. S. invicta was by far the most common species (on 431 nests); S. geminata and W. auropunctata were uncommon (on 3 and 16 nests, respectively). In 2000, 62.5% of nests had ants present (35.9% with S. invicta), but in 2001, only 30.5% of the nests had ants present (16.4% with S. invicta). Turtle nests closer to dune vegetation had significantly greater exposure to ants. Differences in ant presence on turtle nests between years and among turtle species were closely related to differences in nest placement relative to dune vegetation. Beach replenishment significantly lowered exposure of nests to ants because on the wider beaches turtles nested farther from the dune vegetation. Selective pressures on nesting sea turtles are altered both by the presence of predaceous ants and the practice of beach replenishment.

Design and Evaluation of a Clock Multiplexing Circuit for the SSRL Booster Accelerator Timing System - Oral Presentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Araya, Million

2015-08-25

SPEAR3 is a 234 m circular storage ring at SLAC’s synchrotron radiation facility (SSRL) in which a 3 GeV electron beam is stored for user access. Typically the electron beam decays with a time constant of approximately 10hr due to electron lose. In order to replenish the lost electrons, a booster synchrotron is used to accelerate fresh electrons up to 3GeV for injection into SPEAR3. In order to maintain a constant electron beam current of 500mA, the injection process occurs at 5 minute intervals. At these times the booster synchrotron accelerates electrons for injection at a 10Hz rate. A 10Hzmore » 'injection ready' clock pulse train is generated when the booster synchrotron is operating. Between injection intervalswhere the booster is not running and hence the 10 Hz ‘injection ready’ signal is not present-a 10Hz clock is derived from the power line supplied by Pacific Gas and Electric (PG&E) to keep track of the injection timing. For this project I constructed a multiplexing circuit to 'switch' between the booster synchrotron 'injection ready' clock signal and PG&E based clock signal. The circuit uses digital IC components and is capable of making glitch-free transitions between the two clocks. This report details construction of a prototype multiplexing circuit including test results and suggests improvement opportunities for the final design.« less

Immediate effects of reiki on heart rate variability, cortisol levels, and body temperature in health care professionals with burnout.

PubMed

Díaz-Rodríguez, Lourdes; Arroyo-Morales, Manuel; Fernández-de-las-Peñas, Cesar; García-Lafuente, Francisca; García-Royo, Carmen; Tomás-Rojas, Inmaculada

2011-10-01

Burnout is a work-related mental health impairment comprising three dimensions: emotional exhaustion, depersonalization, and reduced personal accomplishment. Reiki aims to help replenish and rebalance the body's energetic system, thus stimulating the healing process. The objective of this placebo-controlled, repeated measures, crossover, single-blind, randomized trial was to analyze the immediate effects of Reiki on heart rate variability (HRV), body temperature, and salivary flow rate and cortisol level in health care professionals with burnout syndrome (BS). Participants included 21 health care professionals with BS, who were asked to complete two visits to the laboratory with a 1-week interval between sessions. They were randomly assigned the order in which they would receive a Reiki session applied by an experienced therapist and a placebo treatment applied by a therapist with no knowledge of Reiki, who mimicked the Reiki treatment. Temperature, Holter ECG recordings (standard deviation of the normal-to-normal interval [SDNN], square root of mean squared differences of successive NN intervals [RMSSD], HRV index, low frequency component [LF], and high frequency component [HF]), salivary flow rate and cortisol levels were measured at baseline and postintervention by an assessor blinded to allocation group. SDNN and body temperature were significantly higher after the Reiki treatment than after the placebo. LF was significantly lower after the Reiki treatment. The decrease in the LF domain was associated with the increase in body temperature. These results suggest that Reiki has an effect on the parasympathetic nervous system when applied to health care professionals with BS.

Quantifying anthropogenically driven morphologic changes on a barrier island: Fire Island National Seashore, New York

USGS Publications Warehouse

Kratzmann, Meredith G.; Hapke, Cheryl J.

2012-01-01

Beach scraping, beach replenishment, and the presence of moderate development have altered the morphology of the dune–beach system at Fire Island National Seashore, located on a barrier island on the south coast of Long Island, New York. Seventeen communities are interspersed with sections of natural, nonmodified land within the park boundary. Beach width, dune elevation change, volume change, and shoreline change were calculated from light detection and ranging (LIDAR), real-time kinematic global positioning system (RTK GPS), and beach profile data sets at two ∼4 km long study sites. Each site contains both modified (developed, replenished, and/or scraped) and nonmodified (natural) areas. The analysis spans 9 years, from 1998 to 2007, which encompasses both scraping and replenishment events at Fire Island. The objectives of this study were to quantify and compare morphological changes in modified and nonmodified zones, and to identify erosional areas within the study sites.Areas of increased volume and shoreline accretion were observed at both sites and at the western site are consistent with sand replenishment activities. The results indicate that from 1998 to 2007 locations backed by development and that employed beach scraping and/or replenishment as erosion control measures experienced more loss of volume, width, and dune elevation as compared with adjacent nonmodified areas. A detailed analysis of one specific modification, beach scraping, shows distinct morphological differences in scraped areas relative to nonscraped areas of the beach. In general, scraped areas where there is development on the dunes showed decreases in all measured parameters and are more likely to experience overwash during storm events. Furthermore, the rapid mobilization of material from the anthropogenic (scraped) dune results in increased beach accretion downcoast.National park lands are immediately adjacent to developed areas on Fire Island, and even relatively small human-induced modifications can affect park resources and beach–dune response to storms. This study is the first to conduct a systematic analysis on how anthropogenic modifications affect resources at Fire Island National Seashore and provides essential information for effective management and preservation of coastal resources within the park.

Effect of diet on the replenishment of intramyocellular lipids after exercise.

PubMed

Décombaz, J; Fleith, M; Hoppeler, H; Kreis, R; Boesch, C

2000-12-01

Muscle triglycerides are important as a source of energy and in relation to metabolic sensitivity. However, the classic biopsy method does not distinguish intra- from extracellular fat, and their regulation by exercise and diet is largely unknown. Magnetic resonance spectroscopy (MRS) is available to assess the intramyocellular lipid (IMCL) pool non-invasively in humans. The aim of this work was to use sequential MRS measurements of IMCL and glycogen to explore the role of three levels of dietary fat on the replenishment of these energy stores after exercise. Following 2 h of exercise, two subjects (S1, S2) were fed one of three diets (15%, 40% or 70% fat energy), each on a separate occasion. IMCL and glycogen were measured by MRS in the tibialis anterior muscle before, after exercise, and at 10 and at 32 h of recovery. Initial IMCL concentration (mmol.kg-1: 3.0 in S1 and 1.8 in S2) was reduced to 70% after exercise. The rate of replenishment was minimal with the low-fat (mmol.kg-1.24 h-1: 0.7 and 0.0) and much higher with both higher fat diets (mmol.kg-1.24 h-1: 3.1 and 3.2 in S1, 0.7 and 0.9 in S2). Glycogen and IMCL replenishments were inversely correlated. IMCL and glycogen can vary acutely in response to diet after exercise. Studies are needed to determine if such variations occur within the range of ordinary diets and to clarify the functional significance of IMCL in differently active individuals.

Thermal control of low-pressure fractionation processes. [in basaltic magma solidification

NASA Technical Reports Server (NTRS)

Usselman, T. M.; Hodge, D. S.

1978-01-01

Thermal models detailing the solidification paths for shallow basaltic magma chambers (both open and closed systems) were calculated using finite-difference techniques. The total solidification time for closed chambers are comparable to previously published calculations; however, the temperature-time paths are not. These paths are dependent on the phase relations and the crystallinity of the system, because both affect the manner in which the latent heat of crystallization is distributed. In open systems, where a chamber would be periodically replenished with additional parental liquid, calculations indicate that the possibility is strong that a steady-state temperature interval is achieved near a major phase boundary. In these cases it is straightforward to analyze fractionation models of the basaltic liquid evolution and their corresponding cumulate sequences. This steady thermal fractionating state can be invoked to explain large amounts of erupted basalts of similar composition over long time periods from the same volcanic center and some rhythmically layered basic cumulate sequences.

ETARA PC version 3.3 user's guide: Reliability, availability, maintainability simulation model

NASA Technical Reports Server (NTRS)

Hoffman, David J.; Viterna, Larry A.

1991-01-01

A user's manual describing an interactive, menu-driven, personal computer based Monte Carlo reliability, availability, and maintainability simulation program called event time availability reliability (ETARA) is discussed. Given a reliability block diagram representation of a system, ETARA simulates the behavior of the system over a specified period of time using Monte Carlo methods to generate block failure and repair intervals as a function of exponential and/or Weibull distributions. Availability parameters such as equivalent availability, state availability (percentage of time as a particular output state capability), continuous state duration and number of state occurrences can be calculated. Initial spares allotment and spares replenishment on a resupply cycle can be simulated. The number of block failures are tabulated both individually and by block type, as well as total downtime, repair time, and time waiting for spares. Also, maintenance man-hours per year and system reliability, with or without repair, at or above a particular output capability can be calculated over a cumulative period of time or at specific points in time.

BASD: SIRTF Telescope Instrument Changeout and Cryogen Replenishment (STICCR) study

NASA Technical Reports Server (NTRS)

Mord, A. J.; Urbach, A. R.; Poyer, M. E.; Andreozzi, L. C.; Hermanson, L. A.; Snyder, H. A.; Blalock, W. R.; Haight, R. P.

1985-01-01

The Space Infrared Telescope Facility (SIRTF) is a long-life cryogenically cooled space-based telescope for infrared astronomy from 2 micrometer to 700 miocrometers currently under study by NASA-ARC, and planned for launch in approximately the mid 90's. SIRTF will operate as a multi-user facility, initially carrying 3 instruments at the focal plane. It will be cooled to below 2 K by superfluid liquid helium to achieve radiometric sensitivity limited only by the statistical fluctuations in the natural infrared background radiation over most of its spectral range. The lifetime of the mission will be limited by the lifetime of the liquid helium supply, and is currently baselined to be 2 years. The telescope changes required to allow in-space replenishment of the 2,000 liter superfluid helium tank are investigated. A preliminary design for the space services equipment is also developed. The impacts of basing the equipment and servicing on the space station are investigated. Space replenishment and changeout of instruments requires changes to the telescope design and preliminary concepts are presented.

Efficient biostorage below -150 °C, without sacrificial cryogen

NASA Astrophysics Data System (ADS)

Spoor, Philip S.

2017-12-01

Biostorage is a multi-billion dollar business worldwide and growing rapidly; yet the commercially available options force the user to choose either optimal storage temperature (below -137 °C, the “glass transition temperature” of water) or convenience (no cryogen refill). Passive liquid-nitrogen freezers (storage Dewars with liquid nitrogen pooled at the bottom) provide very cold storage (-190 °C) but the LN2 must be replenished as it boils off. The alternative, so-called “ultra-low” vapor-compression freezers, have no cryogens to replenish and are convenient to use, but only reach storage temperatures above -90 °C. In addition, these tend to be inefficient and costly. Chart Industries is introducing a novel combination of a storage Dewar with a cryocooler (the “Fusion” freezer), that can maintain storage temperatures below -150 °C without the need to replenish any cryogen, while drawing less electricity than any ultra-low on the market. This new product also fits into a relatively narrow “demand window” where on-site cryocooling is not merely more convenient, but also more costeffective than liquid nitrogen delivery.

[Introduction of a bar coding pharmacy stock replenishment system in a prehospital emergency medical unit: economical impact].

PubMed

Dupuis, S; Fecci, J-L; Noyer, P; Lecarpentier, E; Chollet-Xémard, C; Margenet, A; Marty, J; Combes, X

2009-01-01

To assess economical impact after introduction of a bar coding pharmacy stock replenishment system in a prehospital emergency medical unit. Observational before and after study. A computer system using specific software and bare-code technology was introduced in the pre hospital emergency medical unit (Smur). Overall activity and costs related to pharmacy were recorded annually during two periods: the first 2 years period before computer system introduction and the second one during the 4 years following this system installation. The overall clinical activity increased by 10% between the two periods whereas pharmacy related costs continuously decreased after the start of pharmacy management computer system use. Pharmacy stock management was easier after introduction of the new stock replenishment system. The mean pharmacy related cost of one patient management was 13 Euros before and 9 Euros after the introduction of the system. The overall cost savings during the studied period was calculated to reach 134,000 Euros. The introduction of a specific pharmacy management computer system allowed to do important costs savings in a prehospital emergency medical unit.

SIRTF Telescope Instrument Changeout and Cryogen Replenishment (STICCR) Study

NASA Technical Reports Server (NTRS)

Nast, T. C.; Frank, D.; Liu, C. K.; Parmley, R. T.; Jaekle, D.; Builteman, H.; Schmidt, J.; Frederking, T. H. K.

1985-01-01

The Space Infrared Telescope Facility (SIRTF) is a long-life cryogenically cooled space-based telescope for infrared astronomy from 2 to 700 micrometers. SIRTF is currently under study by NASA-ARC (Reference AP) and planned for launch in approximately the mid 1990s. SIRTF will operate as a multiuser facility, initially carrying three instruments at the focal plane. It will be cooled to below 2 K by superfluid liquid helium to achieve radiometric sensitivity limited only by the statistical fluctuations in the natural infrared background radiation over most of its spectral range. The lifetime of the mission will be limited by the lifetime of the liquid helium supply, and baseline is currently to be 2 years. The telescope changes required to allow in-space replenishment of the 4,000-L superfluid helium tank was investigated. A preliminary design for the space services equipment was also developed. The impacts of basing the equipment and servicing on the space station were investigated. Space replenishment and changeout of instruments required changes to the telescope design. Preliminary concepts are presented.

Silicon web process development

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Seidensticker, R. G.; Mchugh, J. P.; Hill, F. E.; Skutch, M. E.; Driggers, J. M.; Hopkins, R. H.

1980-01-01

A barrier crucible design which consistently maintains melt stability over long periods of time was successfully tested and used in long growth runs. The pellet feeder for melt replenishment was operated continuously for growth runs of up to 17 hours. The liquid level sensor comprising a laser/sensor system was operated, performed well, and meets the requirements for maintaining liquid level height during growth and melt replenishment. An automated feedback loop connecting the feed mechanism and the liquid level sensing system was designed and constructed and operated successfully for 3.5 hours demonstrating the feasibility of semi-automated dendritic web growth. The sensitivity of the cost of sheet, to variations in capital equipment cost and recycling dendrites was calculated and it was shown that these factors have relatively little impact on sheet cost. Dendrites from web which had gone all the way through the solar cell fabrication process, when melted and grown into web, produce crystals which show no degradation in cell efficiency. Material quality remains high and cells made from web grown at the start, during, and the end of a run from a replenished melt show comparable efficiencies.

Ethane's 12C/13C Ratio in Titan: Implications for Methane Replenishment

NASA Technical Reports Server (NTRS)

Jennings, Donald E.; Nixon, C. A.; Romani, P. N.; Bjoraker, G. L.; Sada, P. V.; Lunsford, A. W.; Boyle, R. J.; Hesman, B. E.; McCabe, G. H.

2009-01-01

As the .main destination of carbon in the destruction of methane in the atmosphere of Titan, ethane provides information about the carbon isotopic composition of the reservoir from which methane is replenished. If the amount of methane entering the atmosphere is presently equal to the amount converted to ethane, the 12C/13C ratio in ethane should be close to the ratio in the reservoir. We have measured the 12C/13C ratio in ethane both with Cassini CIRS(exp 1) and from the ground and find that it is very close to the telluric standard and outer planet values (89), consistent with a primordial origin for the methane reservoir. The lower 12C/13C ratio measured for methane by Huygens GCMS (82.3) can be explained if the conversion of CH4 to CH3 (and C2H6) favors 12C over 13C with a carbon kinetic isotope effect of 1.08. The time required for the atmospheric methane to reach equilibrium, i.e., for replenishment to equal destruction, is approximately 5 methane atmospheric lifetimes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wuehrmann, A.H.; Jamison, H.C.; Manson-Hing, L.R.

Although most users of ionizing radiation are constantly being subjected to increasing amounts of legislation designed to protect the public from excessive exposure, thus far, regulatory measures relating to dentistry have been concerned with barrier materials and use of protective leaded aprons for patients. No effort has been made to establish laws or regulations where professional judgment is required, and dentists are not restricted as to the number of exposures they may make or the speed of the film emulsion they must use. No individual or agency inspects the quality of the finished film or evaluates the individual practitioner's abilitymore » to interpret accurately the resultant roentgenogram; the dentist is simply expected to avoid needless, useless, or wasteful exposure of his patients. To assess the need for improved x-ray film development techniques, which would result in decreased patient exposure, a survey was made in 195 dentists' offices. Only 25 darkrooms examined had no apparent light leaks. There was no safelight in 7 darkrooms, and safelights were judged inadequate in 67 and adequate in 117 darkrooms. A solution thermometer was available in 106 of the 195 darkrooms. In 168 offices, film processing was done on a time-temperature basis (ordinarily 5 min development at 65 deg F or 41/ 2 min at 68 deg ). A solution-replenishing system was used in 23 darkrooms. The darkroom was also evaluated in its general appearance, tidiness, and arrangement on a subjective scale. Twenty-six darkrooms were rated good, 105 fair, and 60 poor. Twenty-seven of the offices reported that a sight developing technique was used, compared with 168 using a time-temperature technique. The time-temperature procedure did not follow manufacturer's directions in many of the offices because of the absence of solution thermometers and temperature-regulating equipment. A stop bath was used in only three offices. The interval of rinsing between developing and fixing of film ranged from no rinsing to 90 sec. The time intervals during which films were fixed ranged from 2 min to 2 hr. The inadequacy of many of the darkroom techniques is discussed and recommendations are made for improvements designed to reduce duration and repetition of x-ray exposures of patients. Nonoptimal film quality results in unnecessary patient exposure (BBB)« less

The optimal inventory policy for EPQ model under trade credit

NASA Astrophysics Data System (ADS)

Chung, Kun-Jen

2010-09-01

Huang and Huang [(2008), 'Optimal Inventory Replenishment Policy for the EPQ Model Under Trade Credit without Derivatives International Journal of Systems Science, 39, 539-546] use the algebraic method to determine the optimal inventory replenishment policy for the retailer in the extended model under trade credit. However, the algebraic method has its limit of application such that validities of proofs of Theorems 1-4 in Huang and Huang (2008) are questionable. The main purpose of this article is not only to indicate shortcomings but also to present the accurate proofs for Huang and Huang (2008).

A unified convergence theory of a numerical method, and applications to the replenishment policies.

PubMed

Mi, Xiang-jiang; Wang, Xing-hua

2004-01-01

In determining the replenishment policy for an inventory system, some researchers advocated that the iterative method of Newton could be applied to the derivative of the total cost function in order to get the optimal solution. But this approach requires calculation of the second derivative of the function. Avoiding this complex computation we use another iterative method presented by the second author. One of the goals of this paper is to present a unified convergence theory of this method. Then we give a numerical example to show the application of our theory.

A feasibility study of methods for stopping the depletion of ozone over Antarctica

NASA Technical Reports Server (NTRS)

1988-01-01

Ways of stopping the ozone depletion in the ozone hole over Antarctica were studied. The basic objectives were: (1) to define and understand the phenomenon of the ozone hole; (2) to determine possible methods of stopping the ozone depletion; (3) to identify unknowns about the hole and possible solutions. Two basic ways of attacking the problem were identified. First is replenishment of ozone as it is being depleted. Second is elimination of ozone destroying agents from the atmosphere. The second method is a more permanent form of the solution. Elimination and replenishment methods are discussed in detail.

Energy spectrum and kinetics of the fusing particles

NASA Astrophysics Data System (ADS)

Ryutov, D. D.; Putvinski, s. V.; Yushmanov, P. N.; TAE Team

2017-10-01

The fusing particles (e.g., D and T, or p and 11B) contribution to the reaction rate can be found by the integration of the fusion reactivity over the particle distribution functions. The distribution function (e.g., Maxwellian) is depleted in the energy range determined by the highest reactivity and has to be replenished by particle collisions. The kinetics of the replenishment process may affect the rate of fusion energy release. We present a simple analysis of the corresponding kinetic problems for the conditions typical for the standard and advanced-fuel fusion reactions and assess the possible effect on the reaction yield.

Assessing stability and performance of a digitally enabled supply chain: Retrospective of a pilot in Uttar Pradesh, India.

PubMed

Gilbert, Sarah Skye; Thakare, Neeraj; Ramanujapuram, Arun; Akkihal, Anup

2017-04-19

Immunization supply chains in low resource settings do not always reach children with necessary vaccines. Digital information systems can enable real time visibility of inventory and improve vaccine availability. In 2014, a digital, mobile/web-based information system was implemented in two districts of Uttar Pradesh, India. This retrospective investigates improvements and stabilization of supply chain performance following introduction of the digital information system. All data were collected via the digital information system between March 2014 and September 2015. Data included metadata and transaction logs providing information about users, facilities, and vaccines. Metrics evaluated include adoption (system access, timeliness and completeness), data quality (error rates), and performance (stock availability on immunization session days, replenishment response duration, rate of zero stock events). Stability was defined as the phase in which quality and performance metrics achieved equilibrium rates with minimal volatility. The analysis compared performance across different facilities and vaccines. Adoption appeared sufficiently high from the onset to commence stability measures of data quality and supply chain performance. Data quality stabilized from month 3 onwards, and supply chain performance stabilized from month 13 onwards. For data quality, error rates reduced by two thirds post stabilization. Although vaccine availability remained high throughout the pilot, the three lowest-performing facilities improved from 91.05% pre-stability to 98.70% post-stability (p<0.01; t-test). Average replenishment duration (as a corrective response to stock-out events) decreased 52.3% from 4.93days to 2.35days (p<0.01; t-test). Diphtheria-tetanus-pertussis vaccine was significantly less likely to be stocked out than any other material. The results suggest that given sufficient adoption, stability is sequentially achieved, beginning with data quality, and then performance. Identifying when a pilot stabilizes can enable more predictable, reliable cost estimates, and outcome forecasts in the scale-up phase. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

New strategies for improving stem cell therapy in ischemic heart disease.

PubMed

Huang, Peisen; Tian, Xiaqiu; Li, Qing; Yang, Yuejin

2016-11-01

Stem cell therapy is a promising approach to the treatment of ischemic heart disease via replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials have indicated that cardiac function improved consistently, but very modestly after cell-based therapy. This mainly attributed to low cell survival rate, engraftment and functional integration, which became the major challenges to regenerative medicine. In recent years, several new cell types have been developed to regenerate cardiomyocytes and novel delivery approaches helped to increase local cell retention. New strategies, such as cell pretreatment, gene-based therapy, tissue engineering, extracellular vesicles application and immunologic regulation, have surged and brought about improved cell survival and functional integration leading to better therapeutic effects after cell transplantation. In this review, we summarize these new strategies targeting at challenges of cardiac regenerative medicine and discuss recent evidences that may hint their effectiveness in the future clinical settings.

The cognitive benefits of interacting with nature.

PubMed

Berman, Marc G; Jonides, John; Kaplan, Stephen

2008-12-01

We compare the restorative effects on cognitive functioning of interactions with natural versus urban environments. Attention restoration theory (ART) provides an analysis of the kinds of environments that lead to improvements in directed-attention abilities. Nature, which is filled with intriguing stimuli, modestly grabs attention in a bottom-up fashion, allowing top-down directed-attention abilities a chance to replenish. Unlike natural environments, urban environments are filled with stimulation that captures attention dramatically and additionally requires directed attention (e.g., to avoid being hit by a car), making them less restorative. We present two experiments that show that walking in nature or viewing pictures of nature can improve directed-attention abilities as measured with a backwards digit-span task and the Attention Network Task, thus validating attention restoration theory.

Rest-Stress Limb Perfusion Imaging in Humans with Contrast Ultrasound Using Intermediate-Power Imaging and Microbubbles Resistant to Inertial Cavitation.

PubMed

Davidson, Brian P; Hodovan, James; Belcik, J Todd; Moccetti, Federico; Xie, Aris; Ammi, Azzdine Y; Lindner, Jonathan R

2017-05-01

Contrast-enhanced ultrasound (CEU) limb perfusion imaging is a promising approach for evaluating peripheral artery disease (PAD). However, low signal enhancement in skeletal muscle has necessitated high-power intermittent imaging algorithms, which are not clinically feasible. We hypothesized that CEU using a combination of intermediate power and a contrast agent resistant to inertial cavitation would allow real-time limb stress perfusion imaging. In normal volunteers, CEU of the calf skeletal muscle was performed on separate days with Sonazoid, Optison, or Definity. Progressive reduction in the ultrasound pulsing interval was used to assess the balance between signal enhancement and agent destruction at escalating mechanical indices (MI, 0.1-0.4). Real-time perfusion imaging at MI 0.1-0.4 using postdestructive replenishment kinetics was performed at rest and during 25 W plantar flexion contractile exercise. For Optison, limb perfusion imaging was unreliable at rest due to very low signal enhancement generated at all MIs and was possible during exercise-induced hyperemia only at MI 0.1 due to agent destruction at higher MIs. For Definity, signal intensity progressively increased with MI but was offset by microbubble destruction, which resulted in modest signal enhancement during CEU perfusion imaging and distortion of replenishment curves at MI ≥ 0.2. For Sonazoid, there strong signal enhancement at MI ≥ 0.2, with little destruction detected only at MI 0.4. Accordingly, high signal intensity and nondistorted perfusion imaging was possible at MI 0.2-0.3 and detected an 8.0- ± 5.7-fold flow reserve. Rest-stress limb perfusion imaging in humans with real-time CEU, which requires only seconds to perform, is possible using microbubbles with viscoelastic properties that produce strong nonlinear signal generation without destruction at intermediate acoustic pressures. Copyright © 2016 American Society of Echocardiography. All rights reserved.

Bone marrow chimeric mice reveal a role for CX₃CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium.

PubMed

Vukovic, Jana; Blomster, Linda V; Chinnery, Holly R; Weninger, Wolfgang; Jung, Steffen; McMenamin, Paul G; Ruitenberg, Marc J

2010-10-01

Macrophages in the olfactory neuroepithelium are thought to play major roles in tissue homeostasis and repair. However, little information is available at present about possible heterogeneity of these monocyte-derived cells, their turnover rates, and the role of chemokine receptors in this process. To start addressing these issues, this study used Cx₃cr1(gfp) mice, in which the gene sequence for eGFP was knocked into the CX₃CR1 gene locus in the mutant allele. Using neuroepithelial whole-mounts from Cx₃cr1(gfp/+) mice, we show that eGFP(+) cells of monocytic origin are distributed in a loose network throughout this tissue and can be subdivided further into two immunophenotypically distinct subsets based on MHC-II glycoprotein expression. BM chimeric mice were created using Cx₃cr1(gfp/+) donors to investigate turnover of macrophages (and other monocyte-derived cells) in the olfactory neuroepithelium. Our data indicate that the monocyte-derived cell population in the olfactory neuroepithelium is actively replenished by circulating monocytes and under the experimental conditions, completely turned over within 6 months. Transplantation of Cx₃cr1(gfp/gfp) (i.e., CX₃CR1-deficient) BM partially impaired the replenishment process and resulted in an overall decline of the total monocyte-derived cell number in the olfactory epithelium. Interestingly, replenishment of the CD68(low)MHC-II(+) subset appeared minimally affected by CX₃CR1 deficiency. Taken together, the established baseline data about heterogeneity of monocyte-derived cells, their replenishment rates, and the role of CX₃CR1 provide a solid basis to further examine the importance of different monocyte subsets for neuroregeneration at this unique frontier with the external environment.

Cellular metabolic responses of the marine diatom Pseudo-nitzschia multiseries associated with cell wall formation.

PubMed

Xu, Bin; Luo, Chun-Shan; Liang, Jun-Rong; Chen, Dan-Dan; Zhuo, Wen-Hao; Gao, Ya-Hui; Chen, Chang-Ping; Song, Si-Si

2014-08-01

In this study a comparative proteomics approach involving a mass spectrometric analysis of synchronized cells was employed to investigate the cellular-level metabolic mechanisms associated with siliceous cell wall formation in the pennate diatom Pseudo-nitzschia multiseries. Cultures of P. multiseries were synchronized using the silicate limitation method. Approximately 75% of cells were arrested at the G2+M phase of the cell cycle after 48 h of silicate starvation. The majority of cells progressed to new valve synthesis within 5h of silicon replenishment. We compared the proteome of P. multiseries at 0, 4, 5, and 6h of synchronization progress upon silicon replenishment using two-dimensional gel electrophoresis. Forty-eight differentially expressed protein spots were identified in abundance (greater than two-fold change; P<0.005), some of which are predicted to be involved in intracellular trafficking, cytoskeleton, photosynthesis, lipid metabolism, and protein biosynthesis. Cytoskeleton proteins and clathrin coat components were also hypothesized to play potential roles in cell wall formation. The proteomic profile analysis suggests that P. multiseries most likely employs multiple synergistic biochemical mechanisms for cell wall formation. These results improve our understanding of the molecular mechanisms underlying silicon cell wall formation and enhance our understanding of the important role played by diatoms in silicon biogeochemical cycling. Copyright © 2013 Elsevier B.V. All rights reserved.

Onset and demise of Cretaceous oceanic anoxic events: The coupling of surface and bottom oceanic processes in two pelagic basins of the western Tethys

NASA Astrophysics Data System (ADS)

Gambacorta, G.; Bersezio, R.; Weissert, H.; Erba, E.

2016-06-01

The upper Albian-lower Turonian pelagic successions of the Tethys record processes acting during the onset, core, and recovery from perturbed conditions across oceanic anoxic event (OAE) 1d, OAE 2, and the mid-Cenomanian event I (MCE I) relative to intervening intervals. Five sections from Umbria-Marche and Belluno Basins (Italy) were analyzed at high resolution to assess processes in surface and deep waters. Recurrent facies stacking patterns (SP) and their associations record periods of bottom current activity coupled with surface changes in trophic level. Climate changes appear to have been influential on deep circulation dynamics. Under greenhouse conditions, vigorous bottom currents were arguably induced by warm and dense saline deep waters originated on tropical shelves in the Tethys and/or proto-Atlantic Ocean. Tractive facies postdating intermittent anoxia during OAE 1d and in the interval bracketed by MCE I and OAE 2 are indicative of feeble bottom currents, though capable of disrupting stratification and replenish deep water with oxygen. The major warming at the onset of OAE 2 might have enhanced the formation of warm salty waters, possibly producing local hiatuses at the base of the Bonarelli Level and winnowing at the seafloor. Hiatuses detected at the top of the Bonarelli Level possibly resulted from most effective bottom currents during the early Turonian thermal maximum. Times of minimal sediment displacement correlate with cooler climatic conditions and testify a different mechanism of deep water formation, as further suggested by a color change to reddish lithologies of the post-OAE 1d and post-OAE 2 intervals.

Genetic connectivity and self-replenishment of inshore and offshore populations of the endemic anemonefish, Amphiprion latezonatus

NASA Astrophysics Data System (ADS)

Steinberg, Rosemary; van der Meer, Martin; Walker, Emily; Berumen, Michael L.; Hobbs, Jean-Paul A.; van Herwerden, Lynne

2016-09-01

Globally, marine species are under increasing pressure from human activities, including ocean warming, acidification, pollution, and overfishing. Species most vulnerable to these pressures tend to be ecological specialists that have low abundance and small distribution ranges (endemics). Marine endemics often exist as meta-populations distributed among few isolated locations. Determining genetic connectivity among these locations is essential to understanding the recovery potential of endemics after local extinction events. This study examined connectivity in the endemic anemonefish, Amphiprion latezonatus, a habitat specialist with low abundance at most locations. Evolutionary and contemporary migration, genetic diversity, and self-replenishment among the four main locations (Sunshine Coast, North Solitary Island, Lord Howe Island, and Norfolk Island) that comprise the entire A. latezonatus geographic range were assessed using mtDNA and microsatellite markers. Though historical gene flow inferred from mtDNA appeared high, population genetic differentiation was evident and contemporary gene flow inferred from microsatellites was limited, alongside very high (≥89 %) self-replenishment at all locations. Together, these data suggest prolonged recovery times following severe population decline (or extirpation) and indicate a need to protect this species at all locations, particularly Norfolk Island and Sunshine Coast where marine protected areas are lacking.

Source memory in the rat

PubMed Central

Crystal, Jonathon D.; Alford, Wesley T.; Zhou, Wenyi; Hohmann, Andrea G.

2013-01-01

Summary Source memory is a representation of the origin (source) of information. When source information is bound together, it makes a memory episodic, allowing us to differentiate one event from another [1, 2]. Here we asked if rats remember the source of encoded information. Rats foraged for distinctive flavors of food that replenished (or failed to replenish) at its recently encountered location according to a source-information rule. To predict replenishment, rats needed to remember where they had encountered a preferred food type (chocolate) with self-generated (walking along a runway encountering chocolate) or experimenter-generated (placement of the rat at the chocolate site by an experimenter) cues. Three lines of evidence implicate the presence of source memory. First, rats selectively adjusted revisits to the chocolate location based on source information, under conditions in which familiarity of events could not produce successful performance. Second, source memory was dissociated from location memory by different decay rates. Third, temporary inactivation of the CA3 region of the hippocampus with lidocaine selectively eliminated source memory, suggesting that source memory is dependent upon an intact hippocampus. Development of an animal model of source memory may be valuable to probe the biological underpinnings of memory disorders marked by impairments in source memory. PMID:23394830

Antibiotic effectiveness: balancing conservation against innovation.

PubMed

Laxminarayan, Ramanan

2014-09-12

Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As with other such assets, keeping it available requires both conservation and innovation. Conservation encompasses making the best use of current antibiotic effectiveness by reducing demand through vaccination, infection control, diagnostics, public education, incentives for clinicians to prescribe fewer antibiotics, and restrictions on access to newer, last-resort antibiotics. Innovation includes improving the efficacy of current drugs and replenishing effectiveness by developing new drugs. In this paper, I assess the relative benefits and costs of these two approaches to maintaining our ability to treat infections. Copyright © 2014, American Association for the Advancement of Science.

Hematology and plasma chemistry reference intervals for cultured shortnose sturgeon (Acipenser brevirostrum).

PubMed

Knowles, Susan; Hrubec, Terry C; Smith, Stephen A; Bakal, Robert S

2006-12-01

The shortnose sturgeon, Acipenser brevirostrum, is an imperiled species distributed along the Atlantic coast of North America. Interest in replenishing wild stocks with hatchery-reared fish has created a need for accurate hematologic and biochemical reference intervals to evaluate the health of both fish raised in aquaculture systems and fish in the wild. The objective of this study was to generate hematologic and biochemistry reference intervals for healthy shortnose sturgeon. Blood samples were collected in heparinized tubes from 77 shortnose sturgeon raised in flow-through aquaculture systems. Whole blood and plasma samples were analyzed for hematologic and biochemical variables using standard techniques. Reference intervals were calculated as the central 95% (percentile) of data. Hematologic reference intervals (n = 46) were as follows: PCV 26-46%, hemoglobin 5.7-8.7 g/dL, MCV 307-520 fL, MCH 65.9-107.1 pg, MCHC 15-30 g/dL, plasma proteins (refractometry) 2.8-6.0 g/dL, RBC count 0.65-1.09 x 10(6)/microL, total WBC count 28,376-90,789/microL, small lymphocytes 9063-56,656/microL, large lymphocytes 2122-10,435/microL, neutrophils 3758-33,592/microL, monocytes 0-7137/microL, eosinophils 0-1544/microL, thrombocyte-like cells 6863-23,046/microL, thrombocytes 32,205-122,179/microL, and neutrophil:lymphocyte ratio 0.068-1.026. Plasma chemistry reference intervals (n = 77) were as follows: total protein 2.7-5.3 g/dL, albumin 0.8-1.7 g/dL, globulins 1.8-3.7 mg/dL, creatinine 0-1.4 mg/dL, total bilirubin 0-0.1 mg/dL, alkaline phosphatase 47-497 U/L, aspartate aminotransferase 90-311 U/L, sodium 124-141 mmol/L, potassium 2.9-3.7 mmol/L, chloride 106-121 mmol/L, calcium 6.6-12.1 mg/dL, magnesium 1.6-2.3 mg/dL, phosphorus 5.1-8.1 mg/dL, glucose 37-74 mg/dL, cholesterol 42-133 mg/dL, and osmolality 232-289 mOsm/kg. Reference values reported here will be useful for the early detection, identification, and monitoring of disease and sublethal conditions in cultured shortnose sturgeon.

Pricing policy for declining demand using item preservation technology.

PubMed

Khedlekar, Uttam Kumar; Shukla, Diwakar; Namdeo, Anubhav

2016-01-01

We have designed an inventory model for seasonal products in which deterioration can be controlled by item preservation technology investment. Demand for the product is considered price sensitive and decreases linearly. This study has shown that the profit is a concave function of optimal selling price, replenishment time and preservation cost parameter. We simultaneously determined the optimal selling price of the product, the replenishment cycle and the cost of item preservation technology. Additionally, this study has shown that there exists an optimal selling price and optimal preservation investment to maximize the profit for every business set-up. Finally, the model is illustrated by numerical examples and sensitive analysis of the optimal solution with respect to major parameters.

Totally Integrated Munitions Enterprise ''Affordable Munitions Production for the 21st Century''

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burleson, R.R.; Poggio, M.E.; Rosenberg, S.J.

2000-09-13

The U.S. Army faces several munitions manufacturing issues: downsizing of the organic production base, timely fielding of affordable smart munitions, and munitions replenishment during national emergencies. Totally Integrated Munitions Enterprise (TIME) is addressing these complex issues via the development and demonstration of an integrated enterprise. The enterprise will include the tools, network, and open modular architecture controllers to enable accelerated acquisition, shortened concept to volume production, lower life cycle costs, capture of critical manufacturing processes, and communication of process parameters between remote sites to rapidly spin-off production for replenishment by commercial sources. TIME addresses the enterprise as a system, integratingmore » design, engineering, manufacturing, administration, and logistics.« less

Totally Integrated Munitions Enterprise ''Affordable Munitions Production for the 21st Century''

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burleson, R.R.; Poggio, M.E.; Rosenberg, S.J.

2000-07-14

The U.S. Army faces several munitions manufacturing issues: downsizing of the organic production base, timely fielding of affordable smart munitions, and munitions replenishment during national emergencies. TIME is addressing these complex issues via the development and demonstration of an integrated enterprise. The enterprise will include the tools, network, and open modular architecture controller to enable accelerated acquisition, shortened concept to volume production, lower life cycle costs, capture of critical manufacturing processes, and communication of process parameters between remote sites to rapidly spin-off production for replenishment by commercial sources. TIME addresses the enterprise as a system, integrating design, engineering, manufacturing, administration,more » and logistics.« less

Totally Integrated Munitions Enterprise ''Affordable Munitions Production for the 21st Century''

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burleson, R.R.; Poggio, M.E.; Rosenberg, S.J.

2000-08-18

The U.S. Army faces several munitions manufacturing issues: downsizing of the organic production base, timely fielding of affordable smart munitions, and munitions replenishment during national emergencies. Totally Integrated Munitions Enterprise (TIME) is addressing these complex issues via the development and demonstration of an integrated enterprise. The enterprise will include the tools, network, and open modular architecture controllers to enable accelerated acquisition, shortened concept to volume production, lower life cycle costs, capture of critical manufacturing processes, and communication of process parameters between remote sites to rapidly spin-off production for replenishment by commercial sources. TIME addresses the enterprise as a system, integratingmore » design, engineering, manufacturing, administration, and logistics.« less

Acute regulation of IGF-I by alterations in post-exercise macronutrients.

PubMed

Foster, E B; Fisher, G; Sartin, J L; Elsasser, T H; Wu, G; Cowan, W; Pascoe, D D

2012-04-01

This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protocols: (1) placebo (EX); (2) carbohydrate only (CHO); and (3) essential amino acid/carbohydrate (EAA/CHO). Samples were analyzed for growth hormone (GH), free IGF-I, IGFBP-1, IGFBP-2, insulin, hematocrit, hemoglobin, serum leucine, matrix metalloproteinase-9 (MMP-9) proteolytic activity, and presence of IGFBP-3 protease activity. No evidence for IGFBP-3 proteolysis was observed. Significant increases in [free IGF-I] and [leucine] were observed in the EAA/CHO group only. Significant differences were noted in [IGFBP-1] and [IGFBP-2] across conditions. Significant increases in [GH] and MMP-9 activity were observed in all groups. These results indicate that post-exercise macronutrient ratio is a determinant of [free IGF-I], [IGFBP-1 and -2] and may play a role in modulating the IGF-I axis in vivo.

Effect of hypolimnetic oxygenation on oxygen depletion rates in two water-supply reservoirs.

PubMed

Gantzer, Paul A; Bryant, Lee D; Little, John C

2009-04-01

Oxygenation systems, such as bubble-plume diffusers, are used to improve water quality by replenishing dissolved oxygen (DO) in the hypolimnia of water-supply reservoirs. The diffusers induce circulation and mixing, which helps distribute DO throughout the hypolimnion. Mixing, however, has also been observed to increase hypolimnetic oxygen demand (HOD) during system operation, thus accelerating oxygen depletion. Two water-supply reservoirs (Spring Hollow Reservoir (SHR) and Carvins Cove Reservoir (CCR)) that employ linear bubble-plume diffusers were studied to quantify diffuser effects on HOD. A recently validated plume model was used to predict oxygen addition rates. The results were used together with observed oxygen accumulation rates to evaluate HOD over a wide range of applied gas flow rates. Plume-induced mixing correlated well with applied gas flow rate and was observed to increase HOD. Linear relationships between applied gas flow rate and HOD were found for both SHR and CCR. HOD was also observed to be independent of bulk hypolimnion oxygen concentration, indicating that HOD is controlled by induced mixing. Despite transient increases in HOD, oxygenation caused an overall decrease in background HOD, as well as a decrease in induced HOD during diffuser operation, over several years. This suggests that the residual or background oxygen demand decreases from one year to the next. Despite diffuser-induced increases in HOD, hypolimnetic oxygenation remains a viable method for replenishing DO in thermally-stratified water-supply reservoirs such as SHR and CCR.

A Droplet Microfluidic Platform for Automating Genetic Engineering.

PubMed

Gach, Philip C; Shih, Steve C C; Sustarich, Jess; Keasling, Jay D; Hillson, Nathan J; Adams, Paul D; Singh, Anup K

2016-05-20

We present a water-in-oil droplet microfluidic platform for transformation, culture and expression of recombinant proteins in multiple host organisms including bacteria, yeast and fungi. The platform consists of a hybrid digital microfluidic/channel-based droplet chip with integrated temperature control to allow complete automation and integration of plasmid addition, heat-shock transformation, addition of selection medium, culture, and protein expression. The microfluidic format permitted significant reduction in consumption (100-fold) of expensive reagents such as DNA and enzymes compared to the benchtop method. The chip contains a channel to continuously replenish oil to the culture chamber to provide a fresh supply of oxygen to the cells for long-term (∼5 days) cell culture. The flow channel also replenished oil lost to evaporation and increased the number of droplets that could be processed and cultured. The platform was validated by transforming several plasmids into Escherichia coli including plasmids containing genes for fluorescent proteins GFP, BFP and RFP; plasmids with selectable markers for ampicillin or kanamycin resistance; and a Golden Gate DNA assembly reaction. We also demonstrate the applicability of this platform for transformation in widely used eukaryotic organisms such as Saccharomyces cerevisiae and Aspergillus niger. Duration and temperatures of the microfluidic heat-shock procedures were optimized to yield transformation efficiencies comparable to those obtained by benchtop methods with a throughput up to 6 droplets/min. The proposed platform offers potential for automation of molecular biology experiments significantly reducing cost, time and variability while improving throughput.

Oil fuel delivery optimization for multi product and multi depot: the case of petrol station replenishment problem (PSRP)

NASA Astrophysics Data System (ADS)

Surjandari, Isti; Rachman, Amar; Dianawati, Fauzia; Wibowo, R. Pramono

2011-10-01

With the Oil and Gas Law No. 22 of 2001, national and foreign private enterprises can invest in all sectors of Oil and Gas in Indonesia. In anticipation of this free competition, Pertamina, as a state-owned enterprises, which previously had monopolized the oil and gas business activities in Indonesia, should be able to improve services as well as the efficiency in order to compete in the free market, especially in terms of cost efficiency of fuel distribution to gas station (SPBU). To optimize the distribution activity, it is necessary to design a scheduling system and its fuel delivery routes daily to every SPBU. The determination of routes and scheduling delivery of fuel to the SPBU can be modeled as a Petrol Station Replenishment Problem (PSRP) with the multi-depot, multi-product, time windows and split deliveries, which in this study will be completed by the Tabu Search algorithm (TS). This study was conducted in the area of Bandung, the capital of West Java province, which is a big city and the neighboring city of Jakarta, the capital city of Indonesia. By using the fuel delivery data for one day, the results showed a decrease of 16.38% of the distance of the route compared to the current conditions, which impacted on the reduction of distribution costs and decrease the number of total trips by 5.22% and 3.83%.

“A System for Automatically Maintaining Pressure in a Commercial Truck Tire”

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maloney, John

2017-07-07

Under-inflated tires significantly reduce a vehicle’s fuel efficiency by increasing rolling resistance (drag force). The Air Maintenance Technology (“AMT”) system developed through this project replenishes lost air and maintains optimal tire cavity pressure whenever the tire is rolling in service, thus improving overall fuel economy by reducing the tire’s rolling resistance. The system consists of an inlet air filter, an air pump driven by tire deformation during rotation, and a pressure regulating device. Pressurized air in the tire cavity naturally escapes by diffusion through the tire and wheel, leaks in tire seating, and through the filler valve and its seating.more » As a result, tires require constant maintenance to replenish lost air. Since manual tire inflation maintenance is both labor intensive and time consuming, it is frequently overlooked or ignored. By automating the maintenance of optimal tire pressure, the tire’s contribution to the vehicle’s overall fuel economy can be maximized. The work was divided into three phases. The objectives of Phase 1, Planning and Initial Design, resulted in an effective project plan and to create a baseline design. The objectives for Phase 2, Design and Process Optimization, were: to identify finalized design for the pump, regulator and filter components; identify a process to build prototype tires; assemble prototype tires; test prototype tires and document results. The objectives of Phase 3, Design Release and Industrialization, were to finalize system tire assembly, perform release testing and industrialize the assembly process.« less

Source memory in the rat.

PubMed

Crystal, Jonathon D; Alford, Wesley T; Zhou, Wenyi; Hohmann, Andrea G

2013-03-04

Source memory is a representation of the origin (source) of information. When source information is bound together, it makes a memory episodic, allowing us to differentiate one event from another. Here, we asked whether rats remember the source of encoded information. Rats foraged for distinctive flavors of food that replenished (or failed to replenish) at its recently encountered location according to a source-information rule. To predict replenishment, rats needed to remember where they had encountered a preferred food type (chocolate) with self-generated (walking along a runway encountering chocolate) or experimenter-generated (placement of the rat at the chocolate site by an experimenter) cues. Three lines of evidence implicate the presence of source memory. First, rats selectively adjusted revisits to the chocolate location based on source information, under conditions in which familiarity of events could not produce successful performance. Second, source memory was dissociated from location memory by different decay rates. Third, temporary inactivation of the CA3 region of the hippocampus with lidocaine selectively eliminated source memory, suggesting that source memory is dependent upon an intact hippocampus. Development of an animal model of source memory may be valuable to probe the biological underpinnings of memory disorders marked by impairments in source memory. Copyright © 2013 Elsevier Ltd. All rights reserved.

Real-Time Model-Based Leak-Through Detection within Cryogenic Flow Systems

NASA Technical Reports Server (NTRS)

Walker, M.; Figueroa, F.

2015-01-01

The timely detection of leaks within cryogenic fuel replenishment systems is of significant importance to operators on account of the safety and economic impacts associated with material loss and operational inefficiencies. Associated loss in control of pressure also effects the stability and ability to control the phase of cryogenic fluids during replenishment operations. Current research dedicated to providing Prognostics and Health Management (PHM) coverage of such cryogenic replenishment systems has focused on the detection of leaks to atmosphere involving relatively simple model-based diagnostic approaches that, while effective, are unable to isolate the fault to specific piping system components. The authors have extended this research to focus on the detection of leaks through closed valves that are intended to isolate sections of the piping system from the flow and pressurization of cryogenic fluids. The described approach employs model-based detection of leak-through conditions based on correlations of pressure changes across isolation valves and attempts to isolate the faults to specific valves. Implementation of this capability is enabled by knowledge and information embedded in the domain model of the system. The approach has been used effectively to detect such leak-through faults during cryogenic operational testing at the Cryogenic Testbed at NASA's Kennedy Space Center.

An effective hybrid self-adapting differential evolution algorithm for the joint replenishment and location-inventory problem in a three-level supply chain.

PubMed

Wang, Lin; Qu, Hui; Chen, Tao; Yan, Fang-Ping

2013-01-01

The integration with different decisions in the supply chain is a trend, since it can avoid the suboptimal decisions. In this paper, we provide an effective intelligent algorithm for a modified joint replenishment and location-inventory problem (JR-LIP). The problem of the JR-LIP is to determine the reasonable number and location of distribution centers (DCs), the assignment policy of customers, and the replenishment policy of DCs such that the overall cost is minimized. However, due to the JR-LIP's difficult mathematical properties, simple and effective solutions for this NP-hard problem have eluded researchers. To find an effective approach for the JR-LIP, a hybrid self-adapting differential evolution algorithm (HSDE) is designed. To verify the effectiveness of the HSDE, two intelligent algorithms that have been proven to be effective algorithms for the similar problems named genetic algorithm (GA) and hybrid DE (HDE) are chosen to compare with it. Comparative results of benchmark functions and randomly generated JR-LIPs show that HSDE outperforms GA and HDE. Moreover, a sensitive analysis of cost parameters reveals the useful managerial insight. All comparative results show that HSDE is more stable and robust in handling this complex problem especially for the large-scale problem.

An Effective Hybrid Self-Adapting Differential Evolution Algorithm for the Joint Replenishment and Location-Inventory Problem in a Three-Level Supply Chain

PubMed Central

Chen, Tao; Yan, Fang-Ping

2013-01-01

The integration with different decisions in the supply chain is a trend, since it can avoid the suboptimal decisions. In this paper, we provide an effective intelligent algorithm for a modified joint replenishment and location-inventory problem (JR-LIP). The problem of the JR-LIP is to determine the reasonable number and location of distribution centers (DCs), the assignment policy of customers, and the replenishment policy of DCs such that the overall cost is minimized. However, due to the JR-LIP's difficult mathematical properties, simple and effective solutions for this NP-hard problem have eluded researchers. To find an effective approach for the JR-LIP, a hybrid self-adapting differential evolution algorithm (HSDE) is designed. To verify the effectiveness of the HSDE, two intelligent algorithms that have been proven to be effective algorithms for the similar problems named genetic algorithm (GA) and hybrid DE (HDE) are chosen to compare with it. Comparative results of benchmark functions and randomly generated JR-LIPs show that HSDE outperforms GA and HDE. Moreover, a sensitive analysis of cost parameters reveals the useful managerial insight. All comparative results show that HSDE is more stable and robust in handling this complex problem especially for the large-scale problem. PMID:24453822

Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells.

PubMed

Redhai, Siamak; Hellberg, Josephine E E U; Wainwright, Mark; Perera, Sumeth W; Castellanos, Felix; Kroeger, Benjamin; Gandy, Carina; Leiblich, Aaron; Corrigan, Laura; Hilton, Thomas; Patel, Benjamin; Fan, Shih-Jung; Hamdy, Freddie; Goberdhan, Deborah C I; Wilson, Clive

2016-10-01

Regulated secretion by glands and neurons involves release of signalling molecules and enzymes selectively concentrated in dense-core granules (DCGs). Although we understand how many secretagogues stimulate DCG release, how DCG biogenesis is then accelerated to replenish the DCG pool remains poorly characterised. Here we demonstrate that each prostate-like secondary cell (SC) in the paired adult Drosophila melanogaster male accessory glands contains approximately ten large DCGs, which are loaded with the Bone Morphogenetic Protein (BMP) ligand Decapentaplegic (Dpp). These DCGs can be marked in living tissue by a glycophosphatidylinositol (GPI) lipid-anchored form of GFP. In virgin males, BMP signalling is sporadically activated by constitutive DCG secretion. Upon mating, approximately four DCGs are typically released immediately, increasing BMP signalling, primarily via an autocrine mechanism. Using inducible knockdown specifically in adult SCs, we show that secretion requires the Soluble NSF Attachment Protein, SNAP24. Furthermore, mating-dependent BMP signalling not only promotes cell growth, but is also necessary to accelerate biogenesis of new DCGs, restoring DCG number within 24 h. Our analysis therefore reveals an autocrine BMP-mediated feedback mechanism for matching DCG release to replenishment as secretion rates fluctuate, and might explain why in other disease-relevant systems, like pancreatic β-cells, BMP signalling is also implicated in the control of secretion.

Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells

PubMed Central

Redhai, Siamak; Hellberg, Josephine E. E. U.; Wainwright, Mark; Perera, Sumeth W.; Castellanos, Felix; Kroeger, Benjamin; Gandy, Carina; Leiblich, Aaron; Corrigan, Laura; Hilton, Thomas; Patel, Benjamin; Fan, Shih-Jung; Hamdy, Freddie; Goberdhan, Deborah C. I.

2016-01-01

Regulated secretion by glands and neurons involves release of signalling molecules and enzymes selectively concentrated in dense-core granules (DCGs). Although we understand how many secretagogues stimulate DCG release, how DCG biogenesis is then accelerated to replenish the DCG pool remains poorly characterised. Here we demonstrate that each prostate-like secondary cell (SC) in the paired adult Drosophila melanogaster male accessory glands contains approximately ten large DCGs, which are loaded with the Bone Morphogenetic Protein (BMP) ligand Decapentaplegic (Dpp). These DCGs can be marked in living tissue by a glycophosphatidylinositol (GPI) lipid-anchored form of GFP. In virgin males, BMP signalling is sporadically activated by constitutive DCG secretion. Upon mating, approximately four DCGs are typically released immediately, increasing BMP signalling, primarily via an autocrine mechanism. Using inducible knockdown specifically in adult SCs, we show that secretion requires the Soluble NSF Attachment Protein, SNAP24. Furthermore, mating-dependent BMP signalling not only promotes cell growth, but is also necessary to accelerate biogenesis of new DCGs, restoring DCG number within 24 h. Our analysis therefore reveals an autocrine BMP-mediated feedback mechanism for matching DCG release to replenishment as secretion rates fluctuate, and might explain why in other disease-relevant systems, like pancreatic β-cells, BMP signalling is also implicated in the control of secretion. PMID:27727275

Connectivity of a large embayment and coastal fishery: spawning aggregations in one bay source local and broad-scale fishery replenishment.

PubMed

Hamer, P A; Acevedo, S; Jenkins, G P; Newman, A

2011-04-01

Ichthyoplankton sampling and otolith chemistry were used to determine the importance of transient spawning aggregations of snapper Chrysophrys auratus (Sparidae) in a large embayment, Port Phillip Bay (PPB), Australia, as a source of local and broad-scale fishery replenishment. Ichthyoplankton sampling across five spawning seasons within PPB, across the narrow entrance to the bay and in adjacent coastal waters, indicated that although spawning may occur in coastal waters, the spawning aggregations within the bay were the primary source of larval recruitment to the bay. Otolith chemical signatures previously characterized for 0+ year C. auratus of two cohorts (2000 and 2001) were used as the baseline signatures to quantify the contribution that fish derived from reproduction in PPB make to fishery replenishment. Sampling of these cohorts over a 5 year period at various widely dispersed fishery regions, combined with maximum likelihood analyses of the chemistry of the 0+ year otolith portions of these older fish, indicated that C. auratus of 1 to 3+ years of age displayed both local residency and broad-scale emigration from PPB to populate coastal waters and an adjacent bay (Western Port). While the PPB fishery was consistently dominated (>70%) by locally derived fish irrespective of cohort or age, the contribution of fish that had originated from PPB to distant populations increased with age. At 4 to 5+ years of age, when C. auratus mature and fully recruit to the fishery, populations of both cohorts across the entire central and western Victorian fishery, including two major embayments and c. 800 km of coastal waters, were dominated (>70%) by fish that had originated from the spawning aggregations and nursery habitat within PPB. Dependence of this broadly dispersed fishery on replenishment from heavily targeted spawning aggregations within one embayment has significant implications for management and monitoring programmes. © 2011 The Authors. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

Interrupted infusion of echocardiographic contrast as a basis for accurate measurement of myocardial perfusion: ex vivo validation and analysis procedures.

PubMed

Toledo, Eran; Collins, Keith A; Williams, Ursula; Lammertin, Georgeanne; Bolotin, Gil; Raman, Jai; Lang, Roberto M; Mor-Avi, Victor

2005-12-01

Echocardiographic quantification of myocardial perfusion is based on analysis of contrast replenishment after destructive high-energy ultrasound impulses (flash-echo). This technique is limited by nonuniform microbubble destruction and the dependency on exponential fitting of a small number of noisy time points. We hypothesized that brief interruptions of contrast infusion (ICI) would result in uniform contrast clearance followed by slow replenishment and, thus, would allow analysis from multiple data points without exponential fitting. Electrocardiographic-triggered images were acquired in 14 isolated rabbit hearts (Langendorff) at 3 levels of coronary flow (baseline, 50%, and 15%) during contrast infusion (Definity) with flash-echo and with a 20-second infusion interruption. Myocardial videointensity was measured over time from flash-echo sequences, from which characteristic constant beta was calculated using an exponential fit. Peak contrast inflow rate was calculated from ICI data using analysis of local time derivatives. Computer simulations were used to investigate the effects of noise on the accuracy of peak contrast inflow rate and beta calculations. ICI resulted in uniform contrast clearance and baseline replenishment times of 15 to 25 cardiac cycles. Calculated peak contrast inflow rate followed the changes in coronary flow in all hearts at both levels of reduced flow (P < .05) and had a low intermeasurement variability of 7 +/- 6%. With flash-echo, contrast clearance was less uniform and baseline replenishment times were only 4 to 6 cardiac cycles. beta Decreased significantly only at 15% flow, and had intermeasurement variability of 42 +/- 33%. Computer simulations showed that measurement errors in both perfusion indices increased with noise, but beta had larger errors at higher rates of contrast inflow. ICI provides the basis for accurate and reproducible quantification of myocardial perfusion using fast and robust numeric analysis, and may constitute an alternative to the currently used techniques.

Population connectivity and the effectiveness of marine protected areas to protect vulnerable, exploited and endemic coral reef fishes at an endemic hotspot

NASA Astrophysics Data System (ADS)

van der Meer, M. H.; Berumen, M. L.; Hobbs, J.-P. A.; van Herwerden, L.

2015-06-01

Marine protected areas (MPAs) aim to mitigate anthropogenic impacts by conserving biodiversity and preventing overfishing. The effectiveness of MPAs depends on population connectivity patterns between protected and non-protected areas. Remote islands are endemism hotspots for coral reef fishes and provide rare examples of coral reefs with limited fishing pressure. This study explored population genetic connectivity across a network of protected and non-protected areas for the endemic wrasse, Coris bulbifrons, which is listed as "vulnerable" by the IUCN due to its small, decreasing geographic range and declining abundance. Mitochondrial DNA (mtDNA) and microsatellite DNA (msatDNA) markers were used to estimate historic and contemporary gene flow to determine the level of population self-replenishment and to measure genetic and genotypic diversity among all four locations in the species range (south-west Pacific Ocean)—Middleton Reef (MR), Elizabeth Reef (ER), Lord Howe Island (LHI) and Norfolk Island (NI). MPAs exist at MR and LHI and are limited or non-existent at ER and NI, respectively. There was no obvious differentiation in mtDNA among locations, however, msatDNA revealed differentiation between the most peripheral (NI) and all remaining locations (MR, ER and LHI). Despite high mtDNA connectivity ( M = 259-1,144), msatDNA connectivity was limited ( M = 3-9) with high self-replenishment (68-93 %) at all locations. NI is the least connected and heavily reliant on self-replenishment, and the absence of MPAs at NI needs to be rectified to ensure the persistence of endemic species at this location. Other endemic fishes exhibit similar patterns of high self-replenishment across the four locations, indicating that a single spatial management approach consisting of a MPA network protecting part of each location could provide reasonable protection for these species. Thus, the existing network of MPAs at this endemic hotspot appears adequate at some locations, but not at all.

Replenishment of RANTES mRNA expression in activated eosinophils fromatopic asthmatics

PubMed Central

Velazquez, J R; Lacy, P; Moqbel, R

2000-01-01

Eosinophils have been shown to express the gene encoding regulated upon activation, normal T‐cell expressed and secreted (RANTES), a potent eosinophilotactic chemokine. RANTES protein expression in eosinophils has previously been shown to be up‐regulated by a number of agonists, including complement‐dependent factors (C3b/iC3b) and interferon‐γ (IFN‐γ). We hypothesized that gene expression of RANTES is regulated in these cells by eosinophil‐specific agonists. We analysed RANTES mRNA expression by reverse‐transcription polymerase chain reaction (RT‐PCR) in human peripheral blood eosinophils obtained from mild atopic asthmatics following stimulation over time. In resting eosinophils, a low level of RANTES mRNA was found to be constitutively expressed in all the atopic donors tested in this study (n = 6). Following stimulation with C3b/iC3b (serum‐coated surfaces), eosinophils released measurable levels of RANTES, while sustained transcript expression was detected for up to 24 hr of stimulation. In contrast, IFN‐γ (5 ng/ml) transiently and significantly (P < 0·05, n = 3) depleted relative amounts of RANTES PCR product (compared with β2‐microglobulin) after 1–4 hr of stimulation. RANTES transcript was again detectable after 24 hr of IFN‐γ incubation, suggesting that the pool of RANTES mRNA had been replenished. Other eosinophil‐active cytokines, interleukin‐3 (IL‐3), IL‐4, IL‐5 and granulocyte–macrophage colony‐stimulating factor, did not appear to modulate RANTES mRNA expression after 1 hr of incubation. The effect of IFN‐γ on RANTES mRNA was reversed by cycloheximide, suggesting that IFN‐γ may act by increasing the rate of translation of RANTES mRNA. These findings indicate that IFN‐γ may induce a rapid and transient effect on the translation and replenishment of RANTES mRNA in eosinophils. This novel observation supports the notion that eosinophils have the potential to replenish their stored and released bioactive proteins. PMID:10792507

Scales of magmatic replenishment and differentiation on an intermediate spreading mid-ocean ridge segment: Endeavour, Juan de Fuca Ridge

NASA Astrophysics Data System (ADS)

Dreyer, B. M.; Gill, J.; Clague, D. A.

2016-12-01

The aggregate chemistry of mid-ocean ridge (MOR) basalts cannot be produced by fractional crystallization alone. Recent modeling suggests that repeated magmatic replenishment is required (O'Neill and Jenner, 2012; Coogan and O'Hara, 2015; Shorttle, 2015). Does this inference hold when considering recent advancements in characterizing geological/volcanological context, geochemical variability, and temporal parameters on the scale of individual lava units (Rubin et al., 2009)? We evaluate the scales of magmatic replenishment through examination of compositionally diverse lavas from the Endeavour segment of the Juan de Fuca (JdF) MOR interpreted as comagmatic or coeruptive based on robust geological (Clague et al., 2014), geochemical (Gill et al., 2016), and geochronological (Jamieson et al., 2013; Clague et al., 2014) evidence. This approach is similar to that used for historical MOR eruptions (Rubin et al., 2001). We identified 15 "chemomagmatic" units that are spatially proximate and chemically relatable and separable that collectively represent eruptions since 11ka. Some units may be single lava flows. Other units appear to have erupted batches intermittently over hundreds to thousands of years during which chemically dissimilar lava also erupted. Melt evolution was modeled using MELTS for units with reasonably broad major element variations. Fractional crystallization models can adequately reproduce most of the major and incompatible trace element behavior observed within each unit. Consistent differences in trace element ratios between units argue against intermixing. Thus, magmatic batches typically lie within analytical resolution of fractional crystallizing systems, notwithstanding growing evidence that magmatic systems are repeatedly replenished at the segment scale. Melting and mixing of heterogeneous mantle sources are responsible for the overall compositional diversity at Endeavour. Chemomagmatic units, in contrast, reflect smaller scale processing of magma after exiting the melt column during ascent through the crust. Age and spatial relationships among the chemomagmatic units reflect fluctuations in productivity and composition during assembly of primitive mantle melts and the geometry of networked magma-hosting reservoirs.

Portable Plating System

NASA Technical Reports Server (NTRS)

Flores, R.

1984-01-01

Plating system mounted on portable cart includes 30-gallon (23.5 liter) electrolyte tank, filler pump, heaters, replenishing anodes, plating rectifiers and tank rectifier to continously remove contaminants.

A note on `a replenishment policy for items with price-dependent demand, time-proportional deterioration and no shortages'

NASA Astrophysics Data System (ADS)

Shah, Nita H.; Soni, Hardik N.; Gupta, Jyoti

2014-08-01

In a recent paper, Begum et al. (2012, International Journal of Systems Science, 43, 903-910) established pricing and replenishment policy for an inventory system with price-sensitive demand rate, time-proportional deterioration rate which follows three parameters, Weibull distribution and no shortages. In their model formulation, it is observed that the retailer's stock level reaches zero before the deterioration occurs. Consequently, the model resulted in traditional inventory model with price sensitive demand rate and no shortages. Hence, the main purpose of this note is to modify and present complete model formulation for Begum et al. (2012). The proposed model is validated by a numerical example and the sensitivity analysis of parameters is carried out.

An Inventory Model for Special Display Goods with Seasonal Demand

NASA Astrophysics Data System (ADS)

Kawakatsu, Hidefumi

2010-10-01

The present study discusses the retailer's optimal replenishment policy for seasonal products. The demand rate of seasonal merchandise such as clothes, sporting goods, children's toys and electrical home appearances tends to decrease with time after reaching its maximum value. In this study, we focus on "Special Display Goods", which are heaped up in end displays or special areas at retail stores. They are sold at a fast velocity when their quantity displayed is large, but are sold at a low velocity if the quantity becomes small. We develop the model with a finite time horizon (selling period) to determine the optimal replenishment policy, which maximizes the retailer's total profit. Numerical examples are presented to illustrate the theoretical underpinnings of the proposed model.

Disposable penis and its replenishment in a simultaneous hermaphrodite

PubMed Central

Sekizawa, Ayami; Seki, Satoko; Tokuzato, Masakazu; Shiga, Sakiko; Nakashima, Yasuhiro

2013-01-01

Although it is often thought that sexual selection is weaker in simultaneous hermaphrodites than in gonochorists, some simultaneous hermaphrodites exhibit bizarre mating behaviour. In the simultaneously hermaphroditic nudibranch Chromodoris reticulata, we found a peculiar mating behaviour, wherein the nudibranch autotomized its penis after each copulation and was able to copulate again within 24 h. To have sufficient length to be replenished for three copulations, the penis is compressed and spiralled internally. No other animal is known to repeatedly copulate using such ‘disposable penes’. Entangled sperm masses were observed on the outer surface of the autotomized penis, which is equipped with many backward-pointed spines. There is a possibility that the nudibranch removes sperm already stored in a mating partner's sperm storage organ(s). PMID:23407499

Microfabricated valveless devices for thermal bioreactions based on diffusion-limited evaporation.

PubMed

Wang, Fang; Yang, Ming; Burns, Mark A

2008-01-01

Microfluidic devices that reduce evaporative loss during thermal bioreactions such as PCR without microvalves have been developed by relying on the principle of diffusion-limited evaporation. Both theoretical and experimental results demonstrate that the sample evaporative loss can be reduced by more than 20 times using long narrow diffusion channels on both sides of the reaction region. In order to further suppress the evaporation, the driving force for liquid evaporation is reduced by two additional techniques: decreasing the interfacial temperature using thermal isolation and reducing the vapor concentration gradient by replenishing water vapor in the diffusion channels. Both thermal isolation and vapor replenishment techniques can limit the sample evaporative loss to approximately 1% of the reaction content.

Low-Energy Solvents For Carbon Dioxide Capture Enabled By A Combination Of Enzymes And Vacuum Regeneration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salmon, Sonja; House, Alan; Liu, Kun

An integrated bench-scale system combining the attributes of the bio-renewable enzyme carbonic anhydrase (CA) with low-enthalpy CO2 absorption solvents and vacuum regeneration was designed, built and operated for 500 hours using simulated flue gas. The objective was to develop a CO2 capture process with improved efficiency and sustainability when compared to NETL Case 10 monoethanolamine (MEA) scrubbing technology. The use of CA accelerates inter-conversion between dissolved CO2 and bicarbonate ion to enhance CO2 absorption, and the use of low enthalpy CO2 absorption solvents makes it possible to regenerate the solvent at lower temperatures relative to the reference MEA-based solvent. Themore » vacuum regeneration-based integrated bench-scale system operated successfully for an accumulated 500 hours using aqueous 23.5 wt% K2CO3-based solvent containing 2.5 g/L enzyme to deliver an average 84% CO2 capture when operated with a 20% enzyme replenishment rate per ~7 hour steady-state run period. The total inlet gas flow was 30 standard liters per minute with 15% CO2 and 85% N2. The absorber temperature was 40°C and the stripper operated under 35 kPa pressure with an approximate 77°C stripper bottom temperature. Tests with a 30°C absorber temperature delivered >90% capture. On- and off-line operational measurements provided a full process data set, with recirculating enzyme, that allowed for enzyme replenishment and absorption/desorption kinetic parameter calculations. Dissolved enzyme replenishment and conventional process controls were demonstrated as straightforward approaches to maintain system performance. Preliminary evaluation of a novel flow-through ultrasonically enhanced regeneration system was also conducted, yet resulted in CO2 release within the range of temperature-dependent release, and further work would be needed to validate the benefits of ultrasonic enhanced stripping. A full technology assessment was completed in which four techno-economic cases for enzyme-enhanced aqueous K2CO3 solvent with vacuum stripping were considered and a corresponding set of sensitivity studies were developed. The cases were evaluated using bench-scale and laboratory-based observations, AspenPlus® process simulation and modeling, AspenTech’s CCE® Parametric Software, current vendor quotations, and project partners’ know-how of unit operations. Overall, the DOE target of 90% CO2 capture could be met using the benign enzyme-enhanced aqueous K2CO3-based alternative to NETL Case 10. The model-predicted plant COE performance, scaled to 550 MWe net output, was 9% higher than NETL Case 10 for an enzyme-activated case with minimized technical risk and highest confidence in physical system performance utilizing commercially available equipment. A COE improvement of 2.8% versus NETL Case 10 was predicted when favorable features of improved enzyme longevity and additional power output from a very low pressure (VLP) turbine were combined, wherein corresponding high capital and operational costs limited the level of COE benefit. The environmental, health and safety (EH&S) profile of the system was found to be favorable and was compliant with the Federal EH&S legislation reviewed. Further work on a larger scale test unit is recommended to reduce the level of uncertainty inherent in extrapolating findings from a bench-scale unit to a full scale PCC plant, and to further investigate several identified opportunities for improvement. Production feasibility and suitability of carbonic anhydrases for scale-up testing was confirmed both through the current project and through parallel efforts.« less

Trees, soils, and food security

PubMed Central

Sanchez, P. A.; Buresh, R. J.; Leakey, R. R. B.

1997-01-01

Trees have a different impact on soil properties than annual crops, because of their longer residence time, larger biomass accumulation, and longer-lasting, more extensive root systems. In natural forests nutrients are efficiently cycled with very small inputs and outputs from the system. In most agricultural systems the opposite happens. Agroforestry encompasses the continuum between these extremes, and emerging hard data is showing that successful agroforestry systems increase nutrient inputs, enhance internal flows, decrease nutrient losses and provide environmental benefits: when the competition for growth resources between the tree and the crop component is well managed. The three main determinants for overcoming rural poverty in Africa are (i) reversing soil fertility depletion, (ii) intensifying and diversifying land use with high-value products, and (iii) providing an enabling policy environment for the smallholder farming sector. Agroforestry practices can improve food production in a sustainable way through their contribution to soil fertility replenishment. The use of organic inputs as a source of biologically-fixed nitrogen, together with deep nitrate that is captured by trees, plays a major role in nitrogen replenishment. The combination of commercial phosphorus fertilizers with available organic resources may be the key to increasing and sustaining phosphorus capital. High-value trees, 'Cinderella' species, can fit in specific niches on farms, thereby making the system ecologically stable and more rewarding economically, in addition to diversifying and increasing rural incomes and improving food security. In the most heavily populated areas of East Africa, where farm size is extremely small, the number of trees on farms is increasing as farmers seek to reduce labour demands, compatible with the drift of some members of the family into the towns to earn off-farm income. Contrary to the concept that population pressure promotes deforestation, there is evidence that demonstrates that there are conditions under which increasing tree planting is occurring on farms in the tropics through successful agroforestry as human population density increases.

Carbon footprint assessment of Western Australian Groundwater Recycling Scheme

NASA Astrophysics Data System (ADS)

Simms, Andrew; Hamilton, Stacey; Biswas, Wahidul K.

2017-04-01

This research has determined the carbon footprint or the carbon dioxide equivalent (CO2 eq) of potable water production from a groundwater recycling scheme, consisting of the Beenyup wastewater treatment plant, the Beenyup groundwater replenishment trial plant and the Wanneroo groundwater treatment plant in Western Australia, using a life cycle assessment approach. It was found that the scheme produces 1300 tonnes of CO2 eq per gigalitre (GL) of water produced, which is 933 tonnes of CO2 eq higher than the desalination plant at Binningup in Western Australia powered by 100% renewable energy generated electricity. A Monte Carlo Simulation uncertainty analysis calculated a Coefficient of Variation value of 5.4%, thus confirming the accuracy of the simulation. Electricity input accounts for 83% of the carbon dioxide equivalent produced during the production of potable water. The chosen mitigation strategy was to consider the use of renewable energy to generate electricity for carbon intensive groundwater replenishment trial plant. Depending on the local situation, a maximum of 93% and a minimum of 21% greenhouse gas saving from electricity use can be attained at groundwater replenishment trial plant by replacing grid electricity with renewable electricity. In addition, the consideration of vibrational separation (V-Sep) that helps reduce wastes generation and chemical use resulted in a 4.03 tonne of CO2 eq saving per GL of water produced by the plant.

Carbon footprint assessment of Western Australian Groundwater Recycling Scheme.

PubMed

Simms, Andrew; Hamilton, Stacey; Biswas, Wahidul K

2017-04-01

This research has determined the carbon footprint or the carbon dioxide equivalent (CO 2 eq) of potable water production from a groundwater recycling scheme, consisting of the Beenyup wastewater treatment plant, the Beenyup groundwater replenishment trial plant and the Wanneroo groundwater treatment plant in Western Australia, using a life cycle assessment approach. It was found that the scheme produces 1300 tonnes of CO 2 eq per gigalitre (GL) of water produced, which is 933 tonnes of CO 2 eq higher than the desalination plant at Binningup in Western Australia powered by 100% renewable energy generated electricity. A Monte Carlo Simulation uncertainty analysis calculated a Coefficient of Variation value of 5.4%, thus confirming the accuracy of the simulation. Electricity input accounts for 83% of the carbon dioxide equivalent produced during the production of potable water. The chosen mitigation strategy was to consider the use of renewable energy to generate electricity for carbon intensive groundwater replenishment trial plant. Depending on the local situation, a maximum of 93% and a minimum of 21% greenhouse gas saving from electricity use can be attained at groundwater replenishment trial plant by replacing grid electricity with renewable electricity. In addition, the consideration of vibrational separation (V-Sep) that helps reduce wastes generation and chemical use resulted in a 4.03 tonne of CO 2 eq saving per GL of water produced by the plant.

Groundwater rejuvenation in parts of India influenced by water-policy change implementation.

PubMed

Bhanja, Soumendra N; Mukherjee, Abhijit; Rodell, Matthew; Wada, Yoshihide; Chattopadhyay, Siddhartha; Velicogna, Isabella; Pangaluru, Kishore; Famiglietti, James S

2017-08-07

The dwindling groundwater resource of India, supporting almost one fifth of the global population and also the largest groundwater user, has been of great concern in recent years. However, in contrary to the well documented Indian groundwater depletion due to rapid and unmanaged groundwater withdrawal, here for the first time, we report regional-scale groundwater storage (GWS) replenishment through long-term (1996-2014, using more than 19000 observation locations) in situ and decadal (2003-2014) satellite-based groundwater storage measurements in western and southern parts of India. In parts of western and southern India, in situ GWS (GWS obs ) has been decreasing at the rate of -5.81 ± 0.38 km 3 /year (in 1996-2001) and -0.92 ± 0.12 km 3 /year (in 1996-2002), and reversed to replenish at the rate of 2.04 ± 0.20 km 3 /year (in 2002-2014) and 0.76 ± 0.08 km 3 /year (in 2003-2014), respectively. Here, using statistical analyses and simulation results of groundwater management policy change effect on groundwater storage in western and southern India, we show that paradigm shift in Indian groundwater withdrawal and management policies for sustainable water utilization appear to have started replenishing the aquifers in western and southern parts of India.

Holocene depletion and active recharge of the Kalahari groundwaters — A review and an indicative model

NASA Astrophysics Data System (ADS)

De Vries, J. J.

1984-02-01

A paramount question in the evaluation of groundwater resources in the Kalahari semi-desert is whether there is any active infiltration of present-day rainfall to the deep aquifers. Previous investigations with isotope analyses gave evidence of recent recharge but no unanimity about the distribution of this process has been reached until now. The present study investigates whether the regional hydraulic gradient means a modern replenishment, or whether the slope of the piezometric surface should be explained as a residual feature resulting from head decay since the last pluvial period. It is concluded that the hydraulic gradient is most probably of a residual nature, and the replenishment has been less than 0.5 mm yr. -1 during at least the last 4000 yr. or so.

New Methods for Assessing the Fascinating Nature of Nature Experiences

PubMed Central

Joye, Yannick; Pals, Roos; Steg, Linda; Evans, Ben Lewis

2013-01-01

In recent years, numerous environmental psychology studies have demonstrated that contact with nature as opposed to urban settings can improve an individual’s mood, can lead to increased levels of vitality, and can offer an opportunity to recover from stress. According to Attention Restoration Theory (ART) the restorative potential of natural environments is situated in the fact that nature can replenish depleted attentional resources. This replenishment takes place, in part, because nature is deemed to be a source of fascination, with fascination being described as having an “attentional”, an “affective” and an “effort” dimension. However, the claim that fascination with nature involves these three dimensions is to a large extent based on intuition or derived from introspection-based measurement methods, such as self-reports. In three studies, we aimed to more objectively assess whether these three dimensions indeed applied to experiences related to natural environments, before any (attentional) depletion has taken place. The instruments that were used were: (a) the affect misattribution procedure (Study 1), (b) the dot probe paradigm (Study 2) and (c) a cognitively effortful task (Study 3). These instrument were respectively aimed at verifying the affective, attentional and effort dimension of fascination. Overall, the results provide objective evidence for the claims made within the ART framework, that natural as opposed to urban settings are affectively positive (cfr., affective dimension) and that people have an attentional bias to natural (rather than urban) environments (cfr., attentional dimension). The results regarding the effort dimension are less straightforward, and suggest that this dimension only becomes important in sufficiently difficult cognitive tasks. PMID:23922645

New methods for assessing the fascinating nature of nature experiences.

PubMed

Joye, Yannick; Pals, Roos; Steg, Linda; Evans, Ben Lewis

2013-01-01

In recent years, numerous environmental psychology studies have demonstrated that contact with nature as opposed to urban settings can improve an individual's mood, can lead to increased levels of vitality, and can offer an opportunity to recover from stress. According to Attention Restoration Theory (ART) the restorative potential of natural environments is situated in the fact that nature can replenish depleted attentional resources. This replenishment takes place, in part, because nature is deemed to be a source of fascination, with fascination being described as having an "attentional", an "affective" and an "effort" dimension. However, the claim that fascination with nature involves these three dimensions is to a large extent based on intuition or derived from introspection-based measurement methods, such as self-reports. In three studies, we aimed to more objectively assess whether these three dimensions indeed applied to experiences related to natural environments, before any (attentional) depletion has taken place. The instruments that were used were: (a) the affect misattribution procedure (Study 1), (b) the dot probe paradigm (Study 2) and (c) a cognitively effortful task (Study 3). These instrument were respectively aimed at verifying the affective, attentional and effort dimension of fascination. Overall, the results provide objective evidence for the claims made within the ART framework, that natural as opposed to urban settings are affectively positive (cfr., affective dimension) and that people have an attentional bias to natural (rather than urban) environments (cfr., attentional dimension). The results regarding the effort dimension are less straightforward, and suggest that this dimension only becomes important in sufficiently difficult cognitive tasks.

Cost and cost effectiveness of long-lasting insecticide-treated bed nets - a model-based analysis

PubMed Central

2012-01-01

Background The World Health Organization recommends that national malaria programmes universally distribute long-lasting insecticide-treated bed nets (LLINs). LLINs provide effective insecticide protection for at least three years while conventional nets must be retreated every 6-12 months. LLINs may also promise longer physical durability (lifespan), but at a higher unit price. No prospective data currently available is sufficient to calculate the comparative cost effectiveness of different net types. We thus constructed a model to explore the cost effectiveness of LLINs, asking how a longer lifespan affects the relative cost effectiveness of nets, and if, when and why LLINs might be preferred to conventional insecticide-treated nets. An innovation of our model is that we also considered the replenishment need i.e. loss of nets over time. Methods We modelled the choice of net over a 10-year period to facilitate the comparison of nets with different lifespan (and/or price) and replenishment need over time. Our base case represents a large-scale programme which achieves high coverage and usage throughout the population by distributing either LLINs or conventional nets through existing health services, and retreats a large proportion of conventional nets regularly at low cost. We identified the determinants of bed net programme cost effectiveness and parameter values for usage rate, delivery and retreatment cost from the literature. One-way sensitivity analysis was conducted to explicitly compare the differential effect of changing parameters such as price, lifespan, usage and replenishment need. Results If conventional and long-lasting bed nets have the same physical lifespan (3 years), LLINs are more cost effective unless they are priced at more than USD 1.5 above the price of conventional nets. Because a longer lifespan brings delivery cost savings, each one year increase in lifespan can be accompanied by a USD 1 or more increase in price without the cheaper net (of the same type) becoming more cost effective. Distributing replenishment nets each year in addition to the replacement of all nets every 3-4 years increases the number of under-5 deaths averted by 5-14% at a cost of USD 17-25 per additional person protected per annum or USD 1080-1610 per additional under-5 death averted. Conclusions Our results support the World Health Organization recommendation to distribute only LLINs, while giving guidance on the price thresholds above which this recommendation will no longer hold. Programme planners should be willing to pay a premium for nets which have a longer physical lifespan, and if planners are willing to pay USD 1600 per under-5 death averted, investing in replenishment is cost effective. PMID:22475679

Geologic framework influences on the geomorphology of an anthropogenically modified barrier island: Assessment of dune/beach changes at Fire Island, New York

USGS Publications Warehouse

Lentz, E.E.; Hapke, C.J.

2011-01-01

Antecedent geology plays a crucial role in determining the inner-shelf, nearshore, and onshore geomorphology observed in coastal systems. However, the influence of the geologic framework on a system is difficult to extract when evaluating responses to changes due to storms and anthropogenic modifications, and few studies have quantified the potential for these influences in dune/beach environments. This study evaluates topographic change to the dune/beach system at Fire Island, New York over a ten year period (1998-2008) at two sites representing eastern and western reaches of the island where morphology has been shown to vary. The sites are situated along swaths of coast eroding differentially and where the inner shelf geologic framework differs substantially. Fewer large storms occurred in the first half of the study period, compared with the later part of the study period which includes several severe and prolonged extratropical storms. Additionally, a major beach replenishment project was conducted at one of the study sites. Topographic data from LiDAR and RTK GPS surveys are used to construct high-resolution 3D surfaces, which are used to determine volumetric change and to extract 2D alongshore features and profiles for analysis. The study sites help to further characterize morphologic differences between eastern and western reaches of the island. The western site displays higher sand volumes, lower dunes, and a lower gradient profile slope when compared with the eastern site. In addition to these fundamental morphologic differences, the two sites also differ significantly in their response to coastal storms and in the fact that their replenishment histories are different. The replenished areas show reduced vulnerability to storms through minimal volume loss and shoreline accretion that should be considered when evaluating the response of replenished areas to episodic events. We propose that site-specific differences evident throughout the study period can be linked to alongshore variations in the framework geology of the system. Anthropogenic modifications may have intensified differences already inherent in the system. ?? 2010 Elsevier B.V.

Prevalence and Predictive Value of Microvascular Flow Abnormalities after Successful Contemporary Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction.

PubMed

Aggarwal, Sourabh; Xie, Feng; High, Robin; Pavlides, Gregory; Porter, Thomas R

2018-06-01

Although microvascular flow abnormalities have been observed following epicardial recanalization in acute ST-segment elevation myocardial infarction (STEMI), the prevalence and severity of these abnormalities in the current era of rapid percutaneous coronary intervention (PCI) has not been evaluated. The objective of this study was to assess microvascular perfusion (MVP) following successful primary PCI in patients with STEMI and how it affects clinical outcome. In this single-center, retrospective study, 170 patients who successfully underwent emergent PCI for STEMI were assessed using real-time myocardial contrast echocardiography using a continuous infusion of intravenous commercial microbubbles (3% Definity). Three patterns of myocardial contrast replenishment were observed following intermittent high-mechanical index impulses: infarct zone replenishment within 4 sec (normal MVP), delays in contrast replenishment but normal plateau intensity (delayed MVP [dMVP]), and both delays in replenishment and reduced plateau intensity (microvascular obstruction [MVO]). Changes in left ventricular ejection fraction at 6 months and clinical event rate at 12 months (death, recurrent infarction, need for defibrillator placement, or heart failure admission) were compared. Normal MVP was seen in 62 patients (36%), dMVP in 49 (29%), and MVO in 59 (35%). Left anterior descending coronary artery infarct location was the only parameter independently associated with dMVP or MVO, independent of age, cardiac risk factors, door-to-dilation time, pre-PCI Thrombolysis In Myocardial Infarction flow grade, and thrombus burden. A dMVP pattern had a similar reduction in left ventricular ejection fraction as MVO at hospital discharge but had recovery of left ventricular ejection fraction at 6 months and a greater than fourfold lower event rate than the MVO group (P < .001). MVO and dMVP are frequently seen following contemporary successful PCI for STEMI, especially following left anterior descending coronary artery infarction. Despite a similar area at risk, a dMVP pattern has better functional recovery and clinical outcome than MVO. Copyright © 2018 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.

Vitamin D in corticosteroid-naïve and corticosteroid-treated Duchenne muscular dystrophy: what dose achieves optimal 25(OH) vitamin D levels?

PubMed

Alshaikh, Nahla; Brunklaus, Andreas; Davis, Tracey; Robb, Stephanie A; Quinlivan, Ros; Munot, Pinki; Sarkozy, Anna; Muntoni, Francesco; Manzur, Adnan Y

2016-10-01

Assessment of the efficacy of vitamin D replenishment and maintenance doses required to attain optimal levels in boys with Duchenne muscular dystrophy (DMD). 25(OH)-vitamin D levels and concurrent vitamin D dosage were collected from retrospective case-note review of boys with DMD at the Dubowitz Neuromuscular Centre. Vitamin D levels were stratified as deficient at <25 nmol/L, insufficient at 25-49 nmol/L, adequate at 50-75 nmol/L and optimal at >75 nmol/L. 617 vitamin D samples were available from 197 boys (range 2-18 years)-69% from individuals on corticosteroids. Vitamin D-naïve boys (154 samples) showed deficiency in 28%, insufficiency in 42%, adequate levels in 24% and optimal levels in 6%. The vitamin D-supplemented group (463 samples) was tested while on different maintenance/replenishment doses. Three-month replenishment of daily 3000 IU (23 samples) or 6000 IU (37 samples) achieved optimal levels in 52% and 84%, respectively. 182 samples taken on 400 IU revealed deficiency in 19 (10%), insufficiency in 84 (47%), adequate levels in 67 (37%) and optimal levels in 11 (6%). 97 samples taken on 800 IU showed deficiency in 2 (2%), insufficiency in 17 (17%), adequate levels in 56 (58%) and optimal levels in 22 (23%). 81 samples were on 1000 IU and 14 samples on 1500 IU, with optimal levels in 35 (43%) and 9 (64%), respectively. No toxic level was seen (highest level 230 nmol/L). The prevalence of vitamin D deficiency and insufficiency in DMD is high. A 2-month replenishment regimen of 6000 IU and maintenance regimen of 1000-1500 IU/day was associated with optimal vitamin D levels. These data have important implications for optimising vitamin D dosing in DMD. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Drought of 1980-82 in southeast Florida with comparison to the 1961-62 and 1970-71 droughts

USGS Publications Warehouse

Waller, B.G.

1985-01-01

South-central Florida (the Kissimmee Basin) experienced a severe drought during 1980-82, causing Lake Okeechobee--the largest surface-water storage area in south Florida--to reach the lowest stage ever recorded, 9.75 feet above sea level, on July 29, 1981. A prolonged period of deficient rainfall extended from June 1980 to March 1982. On the southeast coast, drought conditions were mitigated on August 16, 1981, when rainfall from Tropical Storm Dennis replenished the coastal aquifers and filled the water conservation areas to near scheduled levels. South Dade County was the only area in south Florida not affected by the drought. Rainfall in the southeast coastal areas had a statistical recurrence ranging from 5 to 20 years whereas the recurrence intervals from some stations in south-central Florida were in excess of 100 years. The 1980-81 drought in southeast Flrodia was not as severe as the 1961-62 or the 1970-71 droughts in terms of rainfall conditions or the effect on water levels. The effects of the drought were less severe because of a combination of water-management practices and periodic rainfall during the otherwise rain-deficient period. (USGS)

World Bank International Development Association Replenishment Act of 2009

THOMAS, 111th Congress

Sen. Kerry, John F. [D-MA

2009-05-01

Senate - 07/16/2009 Placed on Senate Legislative Calendar under General Orders. Calendar No. 112. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A Titration Technique for Demonstrating a Magma Replenishment Model.

ERIC Educational Resources Information Center

Hodder, A. P. W.

1983-01-01

Conductiometric titrations can be used to simulate subduction-setting volcanism. Suggestions are made as to the use of this technique in teaching volcanic mechanisms and geochemical indications of tectonic settings. (JN)

Foulant characteristics comparison in recycling cooling water system makeup by municipal reclaimed water and surface water in power plant.

PubMed

Ping, Xu; Jing, Wang; Yajun, Zhang; Jie, Wang; Shuai, Si

2015-01-01

Due to water shortage, municipal reclaimed water rather than surface water was replenished into recycling cooling water system in power plants in some cities in China. In order to understand the effects of the measure on carbon steel corrosion, characteristics of two kinds of foulant produced in different systems were studied in the paper. Differences between municipal reclaimed water and surface water were analyzed firstly. Then, the weight and the morphology of two kinds of foulant were compared. Moreover, other characteristics including the total number of bacteria, sulfate reducing bacteria, iron bacteria, extracellular polymeric substance (EPS), protein (PN), and polysaccharide (PS) in foulant were analyzed. Based on results, it could be concluded that microbial and corrosive risk would be increased when the system replenished by municipal reclaimed water instead of surface water.

Joint pricing, inventory, and preservation decisions for deteriorating items with stochastic demand and promotional efforts

NASA Astrophysics Data System (ADS)

Soni, Hardik N.; Chauhan, Ashaba D.

2018-03-01

This study models a joint pricing, inventory, and preservation decision-making problem for deteriorating items subject to stochastic demand and promotional effort. The generalized price-dependent stochastic demand, time proportional deterioration, and partial backlogging rates are used to model the inventory system. The objective is to find the optimal pricing, replenishment, and preservation technology investment strategies while maximizing the total profit per unit time. Based on the partial backlogging and lost sale cases, we first deduce the criterion for optimal replenishment schedules for any given price and technology investment cost. Second, we show that, respectively, total profit per time unit is concave function of price and preservation technology cost. At the end, some numerical examples and the results of a sensitivity analysis are used to illustrate the features of the proposed model.

Modeling and measurement of vesicle pools at the cone ribbon synapse: changes in release probability are solely responsible for voltage-dependent changes in release

PubMed Central

Thoreson, Wallace B.; Van Hook, Matthew J.; Parmelee, Caitlyn; Curto, Carina

2015-01-01

Post-synaptic responses are a product of quantal amplitude (Q), size of the releasable vesicle pool (N), and release probability (P). Voltage-dependent changes in presynaptic Ca2+ entry alter post-synaptic responses primarily by changing P but have also been shown to influence N. With simultaneous whole cell recordings from cone photoreceptors and horizontal cells in tiger salamander retinal slices, we measured N and P at cone ribbon synapses by using a train of depolarizing pulses to stimulate release and deplete the pool. We developed an analytical model that calculates the total pool size contributing to release under different stimulus conditions by taking into account the prior history of release and empirically-determined properties of replenishment. The model provided a formula that calculates vesicle pool size from measurements of the initial post-synaptic response and limiting rate of release evoked by a train of pulses, the fraction of release sites available for replenishment, and the time constant for replenishment. Results of the model showed that weak and strong depolarizing stimuli evoked release with differing probabilities but the same size vesicle pool. Enhancing intraterminal Ca2+ spread by lowering Ca2+ buffering or applying BayK8644 did not increase PSCs evoked with strong test steps showing there is a fixed upper limit to pool size. Together, these results suggest that light-evoked changes in cone membrane potential alter synaptic release solely by changing release probability. PMID:26541100

Muscle glycogen depletion and subsequent replenishment affect anaerobic capacity of horses.

PubMed

Lacombe, V A; Hinchcliff, K W; Geor, R J; Baskin, C R

2001-10-01

The purpose of this study was to determine the effect of muscle glycogen depletion and subsequent replenishment on anaerobic capacity of horses. In a blinded crossover study, seven fit horses performed glycogen-depleting exercise on two occasions. Horses were infused after glycogen-depleting exercise with either 6 g/kg body wt of glucose as a 13.5% solution in 0.9% NaCl (Glu) or with 0.9% NaCl (Sal) of equivalent volume. Subsequently, horses performed a high-speed exercise test (120% of maximal rate of oxygen consumption) to estimate maximum accumulated oxygen deficit. Replenishment of muscle glycogen was greater (P < 0.05) in Glu [from 24.7 +/- 7.2 (SE) to 116.5 +/- 7 mmol/kg wet wt before and after infusion, respectively] than in Sal (from 23.4 +/- 7.2 to 47.8 +/- 5.7 mmol/kg wet wt before and after infusion, respectively). Run time to fatigue during the high-speed exercise test (97.3 +/- 8.2 and 70.8 +/- 8.3 s, P < 0.05), maximal accumulated oxygen deficit (105.7 +/- 9.3 and 82.4 +/- 10.3 ml O(2) equivalent/kg, P < 0.05), and blood lactate concentration at the end of the high-speed exercise test (11.1 +/- 1.4 and 9.2 +/- 3.7 mmol/l, P < 0.05) were greater for Glu than for Sal, respectively. We concluded that decreased availability of skeletal muscle glycogen stores diminishes anaerobic power generation and capacity for high-intensity exercise in horses.

Comparison through a prospective and randomized study of two replenishment methods at polyvalent hospitalization units with two-bin storage systems

PubMed

Bernal, José Luis; Mera-Flores, Ana María; Baena Lázaro, Pedro Pablo; Sebastián Viana, Tomás

2017-11-27

Two-bin storage systems increase nursing staff satisfaction and decrease inventories, but the implications that logistic staff would determine the needs of replenishment are unknown. This study aimed to evaluate whether entrust to logistics staff this responsibility at the polyvalent hospitalization units with two-bin storage is associated with higher risk of outstanding orders. This was a prospective randomized experiment whit masking. Outstanding orders were considered variable response, those corresponding to assessments of the logistics staff were included in the control group and those corresponding to the nursing staff in the control group. Concordance between observers was analyzed using the Bland-Altman method; the difference between groups, with the U of Mann-Whitney and the cumulative incidence of outstanding orders and their relative risk was calculated. The mean amount requested by the logistic and nursing staff was 29.9 (SD:167.4) and 36 (SD:190) units respectively, the mean difference between observers was 6.11 (SD:128.95) units and no significant differences were found between groups (p = 0.430). The incidence of outstanding orders was 0.64% in the intervention group and 0.15% in the control group; the relative risk, 2.31 (0.83 - 6.48) and the number of cases required for an outstanding order, 516. Outstanding order relative risk is not associated with the category of the staff that identifies the replenishment needs at the polyvalent hospitalization units.

Improving Growth and Productivity of Oleiferous Brassicas under Changing Environment: Significance of Nitrogen and Sulphur Nutrition, and Underlying Mechanisms

PubMed Central

Anjum, Naser A.; Gill, Sarvajeet S.; Umar, Shahid; Ahmad, Iqbal; Duarte, Armando C.; Pereira, Eduarda

2012-01-01

Mineral nutrients are the integral part of the agricultural systems. Among important plant nutrients, nitrogen (N) and sulphur (S) are known essential elements for growth, development, and various physiological functions in plants. Oleiferous brassicas (rapeseed and mustard) require higher amounts of S in addition to N for optimum growth and yield. Therefore, balancing S-N fertilization, optimization of nutrient replenishment, minimization of nutrient losses to the environment, and the concept of coordination in action between S and N could be a significant strategy for improvement of growth and productivity of oleiferous brassicas. Additionally, positive interaction between S and N has been reported to be beneficial for various aspects of oilseed brassicas. The current paper updates readers on the significance of N and S for the improvement of plant growth, development, and productivity in detail. In addition, S-N nutrition-mediated control of major plant antioxidant defense system components involved in the removal and/or metabolism of stress-induced/generated reactive oxygen species in plants (hence, the control of plant growth, development, and productivity) has been overviewed. PMID:22629181

Advances in biologic augmentation for rotator cuff repair

PubMed Central

Patel, Sahishnu; Gualtieri, Anthony P.; Lu, Helen H.; Levine, William N.

2016-01-01

Rotator cuff tear is a very common shoulder injury that often necessitates surgical intervention for repair. Despite advances in surgical techniques for rotator cuff repair, there is a high incidence of failure after surgery because of poor healing capacity attributed to many factors. The complexity of tendon-to-bone integration inherently presents a challenge for repair because of a large biomechanical mismatch between the tendon and bone and insufficient regeneration of native tissue, leading to the formation of fibrovascular scar tissue. Therefore, various biological augmentation approaches have been investigated to improve rotator cuff repair healing. This review highlights recent advances in three fundamental approaches for biological augmentation for functional and integrative tendon–bone repair. First, the exploration, application, and delivery of growth factors to improve regeneration of native tissue is discussed. Second, applications of stem cell and other cell-based therapies to replenish damaged tissue for better healing is covered. Finally, this review will highlight the development and applications of compatible biomaterials to both better recapitulate the tendon–bone interface and improve delivery of biological factors for enhanced integrative repair. PMID:27750374

Ratio-based lengths of intervals to improve fuzzy time series forecasting.

PubMed

Huarng, Kunhuang; Yu, Tiffany Hui-Kuang

2006-04-01

The objective of this study is to explore ways of determining the useful lengths of intervals in fuzzy time series. It is suggested that ratios, instead of equal lengths of intervals, can more properly represent the intervals among observations. Ratio-based lengths of intervals are, therefore, proposed to improve fuzzy time series forecasting. Algebraic growth data, such as enrollments and the stock index, and exponential growth data, such as inventory demand, are chosen as the forecasting targets, before forecasting based on the various lengths of intervals is performed. Furthermore, sensitivity analyses are also carried out for various percentiles. The ratio-based lengths of intervals are found to outperform the effective lengths of intervals, as well as the arbitrary ones in regard to the different statistical measures. The empirical analysis suggests that the ratio-based lengths of intervals can also be used to improve fuzzy time series forecasting.

Military Sealift Command

Science.gov Websites

well approximately 3 million gallons of jet fuel and 6 million gallons of diesel ship fuel to the USS replenishments-at-sea, delivering 740 pallets of food equipment, as well approximately 3 million gallons of jet

Rubidium atomic frequency standards for GPS Block IIR

NASA Technical Reports Server (NTRS)

Riley, William J.

1990-01-01

The Rubidium Atomic Frequency Standards (RAFS) were provided for the GPS Block IIR NAVSTAR satellites. These satellites will replenish and upgrade the space segment of the Global Positioning System in the mid 1990s. The GPS RAFS Rb clocks are the latest generation of the high-performance rubidium frequency standards. They offer an aging rate in the low pp 10(exp 14)/day range and a drift-corrected 1-day stability in the low pp 10(exp 14) range. The Block IIR version of these devices will have improved performance, higher reliability, smaller size, and greater radiation hardness. The GPS Block IIR atomic clocks have a natural frequency configuration whereby they output a frequency of about 13.4 MHz that is a submultiple of the atomic resonance of Rb (or Cs). The RAFS operates at a low, fixed C-field for increased stability. The GPS Block IIR RAFS design, including the changes and improvements made, and the test results obtained are described.

[Iron Deficiency in Chronic Heart Failure: Diagnostic Algorithm and Present-Day Therapeutic Options].

PubMed

Doehner, Wolfram; Blankenberg, Stefan; Erdmann, Erland; Ertl, Georg; Hasenfuß, Gerd; Landmesser, Ulf; Pieske, Burkert; Schieffer, Bernhard; Schunkert, Heribert; von Haehling, Stephan; Zeiher, Andreas; Anker, Stefan D

2017-05-01

Iron deficiency (ID) occurs in up to 50% of patients with heart failure (HF). Even without presence of anaemia ID contributes to more severe symptoms, increased hospitalization and mortality. A number of randomized controlled trials demonstrated the clinical benefit of replenishment of iron stores with improvement of symptoms and fewer hospitalizations. Assessment of iron status should therefore become routine assessment in newly diagnosed and in symptomatic patients with HF. ID can be identified with simple and straightforward diagnostic steps. Assessment of Ferritin (indicating iron stores) and transferrin saturation (TSAT, indication capability to mobilise internal iron stores) are sufficient to detect ID. In this review a plain diagnostic algorithm for ID is suggested. Confounding factors for diagnosis and adequate treatment of ID in HF are discussed. A regular workup for iron deficiency parameters may benefit patients with heart failure by providing symptomatic improvements and fewer hospitalizations. © Georg Thieme Verlag KG Stuttgart · New York.

Develop and test fuel cell powered on-site integrated total energy systems. Phase 3: Full-scale power plant development

NASA Technical Reports Server (NTRS)

1981-01-01

A schematic and physical layout is given for the 5kW integrated system and the development status of individual components is described. The results of using a one dimensional mathematical model of the 5kW reformer are presented. Plans for a single-tube reformer test unit for the acquisition of temperature profile data are described. Tentative specifications for a 50kW dc-to-ac inverter are listed. Performance data are given on two 3-cell stacks incorporating semiautomatic acid replenishment systems and improved electrocatalysts. A qualification test on methanol/steam reforming catalyst T2107RS is reported, including a portion in which the catalyst was deliberately poisoned with 800 ppm ethanol in the feed.

High-bandwidth continuous-flow arc furnace

DOEpatents

Hardt, David E.; Lee, Steven G.

1996-01-01

A high-bandwidth continuous-flow arc furnace for stream welding applications includes a metal mass contained in a crucible having an orifice. A power source charges an electrode for generating an arc between the electrode and the mass. The arc heats the metal mass to a molten state. A pressurized gas source propels the molten metal mass through the crucible orifice in a continuous stream. As the metal is ejected, a metal feeder replenishes the molten metal bath. A control system regulates the electrode current, shielding gas pressure, and metal source to provide a continuous flow of molten metal at the crucible orifice. Independent control over the electrode current and shield gas pressure decouples the metal flow temperature and the molten metal flow rate, improving control over resultant weld characteristics.

High-bandwidth continuous-flow arc furnace

DOEpatents

Hardt, D.E.; Lee, S.G.

1996-08-06

A high-bandwidth continuous-flow arc furnace for stream welding applications includes a metal mass contained in a crucible having an orifice. A power source charges an electrode for generating an arc between the electrode and the mass. The arc heats the metal mass to a molten state. A pressurized gas source propels the molten metal mass through the crucible orifice in a continuous stream. As the metal is ejected, a metal feeder replenishes the molten metal bath. A control system regulates the electrode current, shielding gas pressure, and metal source to provide a continuous flow of molten metal at the crucible orifice. Independent control over the electrode current and shield gas pressure decouples the metal flow temperature and the molten metal flow rate, improving control over resultant weld characteristics. 4 figs.

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.

PubMed

Torres, Sandra; Matías, Nuria; Baulies, Anna; Nuñez, Susana; Alarcon-Vila, Cristina; Martinez, Laura; Nuño, Natalia; Fernandez, Anna; Caballeria, Joan; Levade, Thierry; Gonzalez-Franquesa, Alba; Garcia-Rovés, Pablo; Balboa, Elisa; Zanlungo, Silvana; Fabrías, Gemma; Casas, Josefina; Enrich, Carlos; Garcia-Ruiz, Carmen; Fernández-Checa, José C

2017-04-01

Niemann Pick type C (NPC) disease is a progressive lysosomal storage disorder caused by mutations in genes encoding NPC1/NPC2 proteins, characterized by neurological defects, hepatosplenomegaly and premature death. While the primary biochemical feature of NPC disease is the intracellular accumulation of cholesterol and gangliosides, predominantly in endolysosomes, mitochondrial cholesterol accumulation has also been reported. As accumulation of cholesterol in mitochondria is known to impair the transport of GSH into mitochondria, resulting in mitochondrial GSH (mGSH) depletion, we investigated the impact of mGSH recovery in NPC disease. We show that GSH ethyl ester (GSH-EE), but not N-acetylcysteine (NAC), restored the mGSH pool in liver and brain of Npc1 -/- mice and in fibroblasts from NPC patients, while both GSH-EE and NAC increased total GSH levels. GSH-EE but not NAC increased the median survival and maximal life span of Npc1 -/- mice. Moreover, intraperitoneal therapy with GSH-EE protected against oxidative stress and oxidant-induced cell death, restored calbindin levels in cerebellar Purkinje cells and reversed locomotor impairment in Npc1 -/- mice. High-resolution respirometry analyses revealed that GSH-EE improved oxidative phosphorylation, coupled respiration and maximal electron transfer in cerebellum of Npc1 -/- mice. Lipidomic analyses showed that GSH-EE treatment had not effect in the profile of most sphingolipids in liver and brain, except for some particular species in brain of Npc1 -/- mice. These findings indicate that the specific replenishment of mGSH may be a potential promising therapy for NPC disease, worth exploring alone or in combination with other options. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Herbal compatibility of traditional Chinese medical formulas for acquired immunodeficiency syndrome.

PubMed

Cui, Meng; Li, Jinghua; Li, Haiyan; Song, Chunxin

2012-09-01

Because herbal compatibility is one of the most important reasons why Traditional Chinese Medcine (TCM) formulas are effective for acquired immunodeficiency syndrome (AIDS), our study aimed to determine the compatibility of herbs based on published AIDS clinical research in Chinese periodicals. To achieve this aim, we designed a new data-mining algorithm according to TCM data characteristics. We found 25 clinical AIDS studies, all using Chinese herbs for treatment, in the Traditional Chinese Medicine Database System, and information on diagnosis and treatment was extracted. To find out herbal compatibility, especially the formulae for herbal combinations, we proposed an improved association rule algorithm based on the frequency of combinations. In this algorithm, all the compatibility relationships were displayed in a tree structure, by which the relationship between formulas and their derivation could be clearly inferred. Data analysis showed that approximately 100 herbs have been used for treating AIDS. Based on the whole herb compatibility tree, we calculated a basic formula for AIDS: Huang Qi combined with Ren Shen, Fu Ling, Bai Zhu, Bai Zhu, Dang Gui, and Bai Shao. This formula, deriving from most of clinical prescriptions, and was chosed by most of clinicians for AIDS treatment. From data mining we found that Qi replenishment and detoxification were the main treatment principles, which coincided with the AIDS pathological mechanism in which immune function is destroyed by human immunodeficiency virus (HIV). Our data-mining results suggest that the core TCM treatment of AIDS is replenishing Qi and detoxification, by which AIDS patients' immune system may be enhanced. Compatibility of Huang Qi with some frequently-used herbs have shown real efficacy in clinical practice, which warrants pharmacological research in the future.

Groundwater recharge in the tropics: a pan-African analysis of observations

NASA Astrophysics Data System (ADS)

Taylor, R. G.

2015-12-01

Groundwater is a vital source of freshwater in sub-Saharan Africa where rainfall and river discharge are unreliable and per-capita reservoir storage is among the lowest in the world. Groundwater is widely considered a distributed, low-cost and climate-resilient option to meet rapidly growing freshwater demand and alleviate endemic poverty by expanding access to safe water and improving food security through irrigation. Recent research indicates that groundwater storage in Africa is about 100 times greater than annual river discharge yet major uncertainties remain in the magnitude and nature of replenishment through recharge as well as the impacts of land-use and climate change. Here, we present newly compiled, multi-decadal observations of groundwater levels from 5 countries (Benin, Burkina Faso, Niger, Tanzania, Uganda) and paired measurements of stable isotope ratios of O and H in precipitation and groundwater at 11 locations. These data reveal both a distinct bias in groundwater recharge to intensive rainfall and rapid recharge pathways (e.g. focused, macropore flow) that are inconsistent with conventional recharge models assuming pore-matrix flow defined by the Darcy-Richards equation. Further the records highlight the substantial influence of land-use change (e.g. conversion of natural, perennial cover to croplands) on groundwater recharge. The compiled observations also provide, for the first time, a pan-African baseline to evaluate the performance of large-scale hydrological models and Land-Surface Models incorporating groundwater in this region. Our results suggest that the intensification of precipitation brought about by global warming favours groundwater replenishment in sub-Saharan Africa. As such, groundwater may prove to be a climate-resilient source of freshwater in the tropics, enabling adaptive strategies such as groundwater-fed irrigation and sustaining domestic and industrial water supplies.

STEM and our future transportation leaders.

DOT National Transportation Integrated Search

2016-02-10

Between 2012 to 2022, 40 to 50 percent of the transportation workforce is expected to : retire taking valuable knowledge with them. State Departments of Transportation (DOT) : are expected to play a significant role in replenishing the workforce pipe...

Bionanocomposites

USDA-ARS?s Scientific Manuscript database

Commonly used polymeric materials, many of which are derived from petroleum, pose problems after their intended life-span. The fast-paced consumption of petroleum (roughly 100'000 times faster than nature can replenish) and the general disposal possibilities, incineration and land filling contribute...

Pellet Feed for Dendritic-Web Growth

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Skutch, M. E.; Mchugh, J. P.

1983-01-01

Melt replenishment system sustains continuous growth of silicon dentritic web for several days. Substantially increases size of batch, limited mainly by level of impurities and life of crucible. Silicon pellets automatically added to crucible sustain crystal growth for days.

Foulant Characteristics Comparison in Recycling Cooling Water System Makeup by Municipal Reclaimed Water and Surface Water in Power Plant

PubMed Central

Ping, Xu; Jing, Wang; Yajun, Zhang; Jie, Wang; Shuai, Si

2015-01-01

Due to water shortage, municipal reclaimed water rather than surface water was replenished into recycling cooling water system in power plants in some cities in China. In order to understand the effects of the measure on carbon steel corrosion, characteristics of two kinds of foulant produced in different systems were studied in the paper. Differences between municipal reclaimed water and surface water were analyzed firstly. Then, the weight and the morphology of two kinds of foulant were compared. Moreover, other characteristics including the total number of bacteria, sulfate reducing bacteria, iron bacteria, extracellular polymeric substance (EPS), protein (PN), and polysaccharide (PS) in foulant were analyzed. Based on results, it could be concluded that microbial and corrosive risk would be increased when the system replenished by municipal reclaimed water instead of surface water. PMID:25893132

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brauner, Edwin Jr.; Carlson, Daniel C.

The Geysers steamfields in northern Sonoma County have produced reliable ''green'' power for many years. An impediment to long-term continued production has been the ability to provide a reliable source of injection water to replace water extracted and lost in the form of steam. The steamfield operators have historcially used cooling towers to recycle a small portion of the steam and have collected water during the winter months using stream extraction. These two sources, however, could not by themselves sustain the steamfield in the long term. The Lake County Reclaimed Water Project (SEGEP) was inititated in 1997 and provides anothermore » source of steamfield replenishment water. The Santa Rosa Geysers Recharge Project provides another significant step in replenishing the steamfield. In addition, the Santa Rosa Geysers Recharge Project has been built with capacity to potentially meet virtually all injection water requirements, when combined with these other sources. Figure 2.1 graphically depicts the combination of injection sources.« less

Achieving Stable Radiation Pressure Acceleration of Heavy Ions via Successive Electron Replenishment from Ionization of a High-Z Material Coating

NASA Astrophysics Data System (ADS)

Shen, X. F.; Qiao, B.; Zhang, H.; Kar, S.; Zhou, C. T.; Chang, H. X.; Borghesi, M.; He, X. T.

2017-05-01

A method to achieve stable radiation pressure acceleration (RPA) of heavy ions from laser-irradiated ultrathin foils is proposed, where a high-Z material coating in front is used. The coated high-Z material, acting as a moving electron repository, continuously replenishes the accelerating heavy ion foil with comoving electrons in the light-sail acceleration stage due to its successive ionization under laser fields with Gaussian temporal profile. As a result, the detrimental effects such as foil deformation and electron loss induced by the Rayleigh-Taylor-like and other instabilities in RPA are significantly offset and suppressed so that stable acceleration of heavy ions are maintained. Particle-in-cell simulations show that a monoenergetic Al13 + beam with peak energy 3.8 GeV and particle number 1 010 (charge >20 nC ) can be obtained at intensity 1 022 W /cm2 .

Method for regeneration of electroless nickel plating solution

DOEpatents

Eisenmann, Erhard T.

1997-01-01

An electroless nickel(EN)/hypophosphite plating bath is provided employing acetic acid/acetate as a buffer and which is, as a result, capable of perpetual regeneration while avoiding the production of hazardous waste. A regeneration process is provided to process the spent EN plating bath solution. A concentrated starter and replenishment solution is provided for ease of operation of the plating bath. The regeneration process employs a chelating ion exchange system to remove nickel cations from spent EN plating solution. Phosphites are then removed from the solution by precipitation. The nickel cations are removed from the ion exchange system by elution with hypophosphorous acid and the nickel concentration of the eluate adjusted by addition of nickel salt. The treated solution and adjusted eluate are combined, stabilizer added, and the volume of resulting solution reduced by evaporation to form the bath starter and replenishing solution.

Analysis of credit linked demand in an inventory model with varying ordering cost.

PubMed

Banu, Ateka; Mondal, Shyamal Kumar

2016-01-01

In this paper, we have considered an economic order quantity model for deteriorating items with two-level trade credit policy in which a delay in payment is offered by a supplier to a retailer and also an another delay in payment is offered by the retailer to his/her all customers. Here, it is proposed that the demand function is dependent on the length of the customer's credit period and also the duration of offering the credit period. In this article, it is considered that the retailer's ordering cost per order depends on the number of replenishment cycles. The objective of this model is to establish a deterministic EOQ model of deteriorating items for the retailer to decide the position of customers credit period and the number of replenishment cycles in finite time horizon such that the retailer gets the maximum profit. Also, the model is explained with the help of some numerical examples.

Mapping organelle motion reveals a vesicular conveyor belt spatially replenishing secretory vesicles in stimulated chromaffin cells.

PubMed

Maucort, Guillaume; Kasula, Ravikiran; Papadopulos, Andreas; Nieminen, Timo A; Rubinsztein-Dunlop, Halina; Meunier, Frederic A

2014-01-01

How neurosecretory cells spatially adjust their secretory vesicle pools to replenish those that have fused and released their hormonal content is currently unknown. Here we designed a novel set of image analyses to map the probability of tracked organelles undergoing a specific type of movement (free, caged or directed). We then applied our analysis to time-lapse z-stack confocal imaging of secretory vesicles from bovine Chromaffin cells to map the global changes in vesicle motion and directionality occurring upon secretagogue stimulation. We report a defined region abutting the cortical actin network that actively transports secretory vesicles and is dissipated by actin and microtubule depolymerizing drugs. The directionality of this "conveyor belt" towards the cell surface is activated by stimulation. Actin and microtubule networks therefore cooperatively probe the microenvironment to transport secretory vesicles to the periphery, providing a mechanism whereby cells globally adjust their vesicle pools in response to secretagogue stimulation.

Exponential Acceleration of VT Seismicity in the Years Prior to Major Eruptions of Basaltic Volcanoes

NASA Astrophysics Data System (ADS)

Lengline, O.; Marsan, D.; Got, J.; Pinel, V.

2007-12-01

The evolution of the seismicity at three basaltic volcanoes (Kilauea, Mauna-Loa and Piton de la Fournaise) is analysed during phases of magma accumulation. We show that the VT seismicity during these time-periods is characterized by an exponential increase at long-time scale (years). Such an exponential acceleration can be explained by a model of seismicity forced by the replenishment of a magmatic reservoir. The increase in stress in the edifice caused by this replenishment is modeled. This stress history leads to a cumulative number of damage, ie VT earthquakes, following the same exponential increase as found for seismicity. A long-term seismicity precursor is thus detected at basaltic volcanoes. Although this precursory signal is not able to predict the onset times of futures eruptions (as no diverging point is present in the model), it may help mitigating volcanic hazards.

Method for regeneration of electroless nickel plating solution

DOEpatents

Eisenmann, E.T.

1997-03-11

An electroless nickel(EN)/hypophosphite plating bath is provided employing acetic acid/acetate as a buffer and which is, as a result, capable of perpetual regeneration while avoiding the production of hazardous waste. A regeneration process is provided to process the spent EN plating bath solution. A concentrated starter and replenishment solution is provided for ease of operation of the plating bath. The regeneration process employs a chelating ion exchange system to remove nickel cations from spent EN plating solution. Phosphites are then removed from the solution by precipitation. The nickel cations are removed from the ion exchange system by elution with hypophosphorus acid and the nickel concentration of the eluate adjusted by addition of nickel salt. The treated solution and adjusted eluate are combined, stabilizer added, and the volume of resulting solution reduced by evaporation to form the bath starter and replenishing solution. 1 fig.

Linking dynamics of transport timescale and variations of hypoxia in the Chesapeake Bay

NASA Astrophysics Data System (ADS)

Hong, Bo; Shen, Jian

2013-11-01

Dissolved oxygen (DO) replenishment in the bottom waters of an estuary depends on physical processes that are significantly influenced by external forcings. The vertical exchange time (VET) is introduced in this study to quantify the physical processes that regulate the DO replenishment in the Chesapeake Bay. A 3-D numerical model was applied to simulate the circulation, VET, and DO. Results indicate that VET is a suitable parameter for evaluating the bottom DO condition over both seasonal and interannual timescales. The VET is negatively correlated with the bottom DO. Hypoxia (DO <2 mg L-1) will develop in the Bay when VET is greater than 23 days in summer if mean total DO consumption rate is about 0.3 g O2 m-3 d-1. This critical VET value may vary around 23 days when the total DO consumption rate changes. The VET volume (volume of water mass with VET >23 days) can account for 77% of variations of hypoxic volume in the main Bay. The VET cannot explain all the DO variations as it can only account for the contribution of physical processes that regulate DO replenishment. It is found that the short-term vertical exchange process is highly controlled by the wind forcing. The VET volume decreases when the high-speed wind events are frequent. The summertime VET volume is less sensitive to short-term variations (pulses) of river discharge. It is sensitive to the total amount of river discharge and the high VET volume can be expected in the wet year.

Implementation of Advanced Warehouses in a Hospital Environment - Case study

NASA Astrophysics Data System (ADS)

Costa, J.; Sameiro Carvalho, M.; Nobre, A.

2015-05-01

In Portugal, there is an increase of costs in the healthcare sector due to several factors such as the aging of the population, the increased demand for health care services and the increasing investment in new technologies. Thus, there is a need to reduce costs, by presenting the effective and efficient management of logistics supply systems with enormous potential to achieve savings in health care organizations without compromising the quality of the provided service, which is a critical factor, in this type of sector. In this research project the implementation of Advanced Warehouses has been studied, in the Hospital de Braga patient care units, based in a mix of replenishment systems approaches: the par level system, the two bin system and the consignment model. The logistics supply process is supported by information technology (IT), allowing a proactive replacement of products, based on the hospital services consumption records. The case study was developed in two patient care units, in order to study the impact of the operation of the three replenishment systems. Results showed that an important inventory holding costs reduction can be achieved in the patient care unit warehouses while increasing the service level and increasing control of incoming and stored materials with less human resources. The main conclusion of this work illustrates the possibility of operating multiple replenishment models, according to the types of materials that healthcare organizations deal with, so that they are able to provide quality health care services at a reduced cost and economically sustainable. The adoption of adequate IT has been shown critical for the success of the project.

Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice.

PubMed

Chinnery, Holly R; Ruitenberg, Marc J; McMenamin, Paul G

2010-09-01

The mouse dura mater, pia mater, and choroid plexus contain resident macrophages and dendritic cells (DCs). These cells participate in immune surveillance, phagocytosis of cellular debris, uptake of antigens from the surrounding cerebrospinal fluid and immune regulation in many pathologic processes. We used Cx3cr1 knock-in, CD11c-eYFP transgenic and bone marrow chimeric mice to characterize the phenotype, density and replenishment rate of monocyte-derived cells in the meninges and choroid plexus and to assess the role of the chemokine receptor CX3CR1 on their number and tissue distribution. Iba-1 major histocompatibility complex (MHC) Class II CD169 CD68 macrophages and CD11c putative DCs were identified in meningeal and choroid plexus whole mounts. Comparison of homozygous and heterozygous Cx3cr1 mice did not reveal CX3CR1-dependancy on density, distribution or phenotype of monocyte-derived cells. In turnover studies, wild type lethally irradiated mice were reconstituted with Cx3cr1/-positive bone marrow and were analyzed at 3 days, 1, 2, 4 and 8 weeks after transplantation. There was a rapid replenishment of CX3CR1-positive cells in the dura mater (at 4 weeks) and the choroid plexus was fully reconstituted by 8 weeks. These data provide the foundation for future studies on the role of resident macrophages and DCs in conditions such as meningitis, autoimmune inflammatory disease and in therapies involving irradiation and hematopoietic or stem cell transplantation.

Long-term effect of beach replenishment on natural recovery of shallow Posidonia oceanica meadows

NASA Astrophysics Data System (ADS)

González-Correa, José M.; Torquemada, Yolanda Fernández; Sánchez Lizaso, José Luis

2008-03-01

The recovery capacity of shallow Posidonia oceanica meadows degraded by beach replenishment eighteen years before was assessed in two impacted meadows and compared with other two undisturbed localities. Inside each locality, we selected randomly three sites separated by 500-1000 m. At site level we study the vitality of P. oceanica meadow assessing the vegetative growth, leaf characteristics, and non-structural carbohydrates of the plants. Additionally, at locality level, silt-clay fraction, organic matter, pH and light intensity incident on the sea bottom were measured to evaluate the environmental conditions. Covering of P. oceanica was significantly lower at the impacted localities while amount of dead "matte" was higher. Leaf production of horizontal rhizomes (14.6 ± 1.11 vs 19.47 ± 1.45 leaves y -1), net total rhizomes recruitment (2.33 ± 0.17 vs 4.3 ± 0.33 branches y -1) and starch concentration (43.625 ± 0.67 vs 54.45 ± 0.74 mg per g of rhizome) at impacted meadows were significantly lower than controls. Leaf features, epiphytes biomass, colonization, elongation and horizontal and vertical rhizome production did not show significant differences. Sediments at impacted localities contained higher silt-clay fraction and higher organic matter load while pH was lower. Light intensity on the sea bottom measured at all localities was over the minimum light requirements estimated for P. oceanica. Our results show that the press impact produced by beach replenishment was enduring in the time slowing natural recovery by 45%. This impact may be related with changes in the sediment features.

Diet Replenishment for Ad-libitum–fed Mice Housed in Social Groups is Compatible with Shelf Life

PubMed Central

Huerkamp, Michael J; Dowdy, Minida R

2008-01-01

Regulatory guidelines and best practices in the care of research animals allow diets milled for laboratory animals to be used within 180 d of formulation but otherwise permit latitude and professional judgment in how and when feed is offered. As such, practices at some research institutions allow for the replenishment (‘topping up’) of fresh chow over that existing in the cage food hopper, rather than complete replacement of the diet on a regular basis. To determine the depletion rate of a pelleted diet as fed from a conventional overhead food hopper, the consumption of full hoppers of food was measured for breeding pairs of mice in production and gender-specific groups of weanlings and juvenile mice kept in ventilated cages at 71.9 ± 0.2 °F (approximately 22.6 °C) and 40% ± 5% relative humidity. Breeding pairs of mice depleted 97% of a 250-g ration within 44 d of offering and consumed diet at a rate of 4.7 ± 0.5 g per mouse daily. Gender-grouped weanling and juvenile mice housed 5 to 6 per cage exhausted more than 99% of a 500-g ration of diet in 24 d and consumed chow at a rate of 3.4 ± 0.3 g per animal daily. These findings suggest that breeding pairs and groups of mice kept 5 to 6 per cage deplete feed at such a rate that diets can be fed by using replenishment provided diet is offered within 5 mo of the milling date. PMID:18459713

A System for Managing Replenishment of a Nutrient Solution Using an Electrical Conductivity Controller

NASA Technical Reports Server (NTRS)

Davis, D.; Dogan, N.; Aglan, H.; Mortley, D.; Loretan, P.

1998-01-01

Control of nutrient solution parameters is very important for the growth and development of plants grown hydroponically. Protocols involving different nutrient solution replenishment times (e.g. one-week, two-week, or two-day replenishment) provide manual periodic control of the nutrient solution's electrical conductivity (EC). Since plants take-up nutrients as they grow, manual control has a drawback in that EC is not held constant between replenishments. In an effort to correct this problem the Center for Food and Environmental Systems for Human Exploration of Space at Tuskegee University has developed a system for managing and controlling levels of EC over a plant's entire growing cycle. A prototype system is being tested on sweetpotato production using the nutrient film technique (NFT), and it is being compared to a system in which sweetpotatoes are grown using NFT with manual control. NASA has played an important role in the development of environmental control systems. They have become a forerunner in growing plants hydroponically with some control systems through the use of networked data acquisition and control using environmental growth chambers. Data acquisition systems which involve the use of real-time, calibration, set points, user panel, and graphical representation programming provide a good method of controlling nutrient solution parameters such as EC and pH [Bledsoe, 19931]. In NASA's Biomass Production Chamber (BPC) at Kennedy Space Center, control is provided by a programmable logic controller (PLC). This is an industrial controller which combines ladder computer logic which has the ability to handle various levels of electrical power. The controller controls temperature, light and other parameters that affect the plant's environment, in the BPC, the Nutrient Delivery System (NIX), a sub-system of the PLC, controls nutrient solution parameters such as EC, pH, and solution levels. When the nutrient EC measurement goes outside a preset range (120-130 mS/m) a set amount of a stock solution of nutrients is automatically added by a metering pump to bring the EC back into operating range [Fortson, 1992]. This paper describes a system developed at Tuskegee University for controlling the EC of a nutrient solution used for growing sweetpotatoes with an EC controller and a computer with LabView data acquisition and instrumentation software. It also describes the preliminary data obtained from the growth of sweetpotatoes using this prototype control system.

Diurnal characteristics of surface level O3 and other important trace gases in New England

NASA Astrophysics Data System (ADS)

Talbot, Robert; Mao, Huiting; Sive, Barkley

2005-05-01

Data obtained from spring 2001 to summer 2003 in New England by the Atmospheric Investigation, Regional Modeling, Analysis and Prediction (AIRMAP) program were used to document the diurnal characteristics of O3, CO2, NO, and during selected intervals hydrocarbon and oxygenated species. The diurnal cycles of O3 and oxygenated species showed a monotonic rise in mixing ratio following sunrise (replenishment) that was mirrored by nighttime removal (depletion) under the nocturnal inversion. The median depletion rate of O3 was 4.9 ppbv h-1 compared to a replenishment rate of 6.2 ppbv h-1. The significant and rapid loss of O3 at night combined with an anthropogenic hydrocarbon signature dominated by a vehicular source led us to the hypothesis that nocturnal O3 depletion represented the combined effects of dry deposition and titration by NO released from mobile sources. Nighttime removal of O3 averaged 31 ppbv (median of 27 ppbv), with ˜11 ppbv due to dry deposition and ˜20 ppbv loss by titration with NO and NO2. The seasonally averaged diurnal cycles of O3 and NO were very similar from year to year, indicating that although there was large variability in the daily levels of these species, their sources/sinks were quite consistent. Moreover, CO2 and selected hydrocarbons exhibited a diurnal cycle opposite to that of O3, with the highest mixing ratios occurring at night. The diurnal cycles of oxygenated compounds such as methanol, acetaldehyde, methyl ethyl ketone, acetone + propanal, methyl vinyl ketone + methacrolein were investigated for a 2 day time period in July 2003. Our data are among the first to illustrate the diurnal cycle of these compounds. We used these species to demonstrate the importance of vertical mixing in driving the diurnal cycle of ground level O3 in New England. Day/night ratios ranged from 2.3 for acetone + propanal to 11 for methyl vinyl ketone + methacrolein. Deposition velocities of 0.5-1 m s-1 were estimated for these species, which are significantly higher than values used in many models. Such efficient removal may have important implications for the chemical impact of these species, at least on a regional scale.

recycle, replenish, reSTORE

ERIC Educational Resources Information Center

Lansburgh, Therese

1976-01-01

Describes projects of the Maryland Committee for the Day Care of Children aimed at cutting day care costs: a recycling center for discarded industrial materials that can be put to educational uses, and workshops for teachers and volunteers in preschool and day care programs. (ED)

[Psychophysiological support for the professional activities of servicemen].

PubMed

Pogodin, Iu I; Novikov, V S; Bochenkov, A A

1998-11-01

Optimal solution of the personnel replenishment problem, the necessity of training and education process improvement in the training centers and schools, the outcome of social, psychological and medical measures greatly depend on the overall physical and mental health state of the servicemen and their professional training quality. On the basis of their long standing experience the authors discuss the traits of the psychophysiological maintenance of the military professional activities of servicemen, in particular--the methodology and theory of professional psychological selection, the importance of body functional indications for the estimation of the fighting capabilities of military units. They examine some prospects for the psychophysiological expertise in the promotion procedures of commanding officers and make a suggestion that psychophysiological maintenance in the Armed Forces would increase its combat capabilities and help to avoid some negative effects in military groups.

Efg Crystal Growth Apparatus And Method

DOEpatents

Mackintosh, Brian H.; Ouellette, Marc

2003-05-13

An improved mechanical arrangement controls the introduction of silicon particles into an EFG (Edge-defined Film-fed Growth) crucible/die unit for melt replenishment during a crystal growth run. A feeder unit injects silicon particles upwardly through a center hub of the crucible/die unit and the mechanical arrangement intercepts the injected particles and directs them so that they drop into the melt in a selected region of the crucible and at velocity which reduces splashing, whereby to reduce the likelihood of interruption of the growth process due to formation of a solid mass of silicon on the center hub and adjoining components. The invention also comprises use of a Faraday ring to alter the ratio of the electrical currents flowing through primary and secondary induction heating coils that heat the crucible die unit and the mechanical arrangement.

78 FR 29100 - Endangered and Threatened Wildlife; 90-Day Finding on Petitions To List the Dusky Shark as...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

..., Revillagigedo Islands, and possibly Chile (NOAA, 1998; Musick et al., 2007). The species can also be found off... replenished by immigrant females from the Southwest Atlantic population. In addition to genetic separation...

Sugar in Moderation: Variable Sugar Diets Affect Short-Term Parasitoid Behavior

USDA-ARS?s Scientific Manuscript database

The biological control potential of parasitic wasps in the field is expected to increase with provisioning of sugar sources, which increase longevity and replenish carbohydrate reserves. Apanteles aristoteliae Viereck is an important parasitoid of Argyrotaenia franciscana (Walsingham), the orange to...

Root zone soil water dynamics and its effects on above ground biomass in cellulosic and grain based bioenergy crops of Midwest USA

NASA Astrophysics Data System (ADS)

Bhardwaj, A. K.; Hamilton, S. K.; van Dam, R. L.; Diker, K.; Basso, B.; Glbrc-Sustainability Thrust-4. 3 Biogeochemistry

2010-12-01

Root-zone soil moisture constitutes an important variable for hydrological and agronomic models. In agriculture, crop yields are directly related to soil moisture, levels that are most important in the root zone area of the soil. One of the most accurate in-situ methods that has established itself as a recognized standard around the world uses Time Domain Reflectometry (TDR) to determine volumetric water content of the soil. We used automated field-to-desk TDR based systems to monitor temporal (1-hr interval) soil moisture variability in 10 different bioenergy cropping systems at the Great Lakes Bioenergy Research Center’s (GLBRC) sustainability research site in south western Michigan, U.S.A. These crops range from high-diversity, low-input grass mixes to low-diversity, high-input crop monocultures. We equipped the 28 x 40 m vegetation plots with 30 cm long TDR probes at seven depths from 10 cm to 1.25 m below surface. The parent material at the site consists of coarse sandy glacial tills in which a soil with an approximately 50cm thick A-Bt horizon has developed. Additional equipment permanently installed for each system includes soil moisture access tubes, multi-depth temperature sensors, and multi-electrode resistivity arrays. The access tubes were monitored using a portable TDR system at bi-weekly intervals. 2D dipole-dipole electrical resistivity tomography (ERT) data are collected in 4-week intervals, while a subset of the electrodes is used for bi-hourly monitoring. The continuous scans (1 hr) provided us the real time changes in water content, replenishment and depletion, providing indications of water uptake by plant roots and potential seasonal water limitation of biomass accumulation. The results show significant seasonal variations between the crops and cropping systems. Significant relationships were observed between soil moisture stress, above-ground biomass and rooting characteristics. The overall goal of the study is to quantify the components of water balance, and identify water quality and water use implications of these cropping systems.Key Words

Effects of mass media campaign exposure intensity and durability on quit attempts in a population-based cohort study.

PubMed

Wakefield, M A; Spittal, M J; Yong, H-H; Durkin, S J; Borland, R

2011-12-01

To assess the extent to which intensity and timing of televised anti-smoking advertising emphasizing the serious harms of smoking influences quit attempts. Using advertising gross rating points (GRPs), we estimated exposure to tobacco control and nicotine replacement therapy (NRT) advertising in the 3, 4-6, 7-9 and 10-12 months prior to follow-up of a replenished cohort of 3037 Australian smokers during 2002-08. Using generalized estimating equations, we related the intensity and timing of advertising exposure from each source to the likelihood of making a quit attempt in the 3 months prior to follow-up. Tobacco control advertising in the 3-month period prior to follow-up, but not in more distant past periods, was related to a higher likelihood of making a quit attempt. Each 1000 GRP increase per quarter was associated with an 11% increase in making a quit attempt [odds ratio (OR) = 1.11, 95% confidence interval (CI) 1.03-1.19, P = 0.009)]. NRT advertising was unrelated to quit attempts. Tobacco control advertising emphasizing the serious harms of smoking is associated with short-term increases in the likelihood of smokers making a quit attempt. Repeated cycles of higher intensity tobacco control media campaigns are needed to sustain high levels of quit attempts.

Dependence of synchronized bursting activity on medium stirring and the perfusion rate in a cultured network of neurons

NASA Astrophysics Data System (ADS)

Heo, Ryoun; Kim, Hyun; Lee, Kyoung J.

2016-05-01

A cultured network of neurons coupled with a multi-electrode-array (MEA) recording system has been a useful platform for investigating various issues in neuroscience and engineering. The neural activity supported by the system can be sensitive to environmental fluctuations, for example, in the medium's nutrient composition, ph, and temperature, and to mechanical disturbances, yet this issue has not been the subject. Especially, a normal practice in maintaining neuronal cell cultures involves an intermittent sequence of medium exchanges, typically at a time interval of a few days, and one such sudden medium exchange is unavoidably accompanied by many unintended disturbances. Here, based on a quantitative time-series analysis of synchronized bursting events, we explicitly demonstrate that such a medium exchange can, indeed, bring a huge change in the existing neural activity. Subsequently, we develop a medium perfusion-stirring system and an ideal protocol that can be used in conjunction with a MEA recording system, providing long-term stability. Specifically, we systematically evaluate the effects of medium stirring and perfusion rates. Unexpectedly, even some vigorous mechanical agitations do not have any impacts on neural activity. On the other hand, too much replenishment ( e.g., 1.8 ml/day for a 1.8-ml dish) of neurobasal medium results in an excitotoxicity.

Saturation thresholds of evoked neural and hemodynamic responses in awake and asleep rats

NASA Astrophysics Data System (ADS)

Schei, Jennifer L.; Van Nortwick, Amy S.; Meighan, Peter C.; Rector, David M.

2011-03-01

Neural activation generates a hemodynamic response to the localized region replenishing nutrients to the area. Changes in vigilance state have been shown to alter the vascular response where the vascular response is muted during wake compared to quiet sleep. We tested the saturation thresholds of the neurovascular response in the auditory cortex during wake and sleep by chronically implanting rats with an EEG electrode, a light emitting diode (LED, 600 nm), and photodiode to simultaneously measure evoked response potentials (ERPs) and evoked hemodynamic responses. We stimulated the cortex with a single speaker click delivered at random intervals 2-13 s at varied stimulus intensities ranging from 45-80 dB. To further test the potential for activity related saturation, we sleep deprived animals for 2, 4, or 6 hours and recorded evoked responses during the first hour recovery period. With increasing stimulus intensity, integrated ERPs and evoked hemodynamic responses increased; however the hemodynamic response approached saturation limits at a lower stimulus intensity than the ERP. With longer periods of sleep deprivation, the integrated ERPs did not change but evoked hemodynamic responses decreased. There may be physical limits in cortical blood delivery and vascular compliance, and with extended periods of neural activity during wake, vessels may approach these limits.

Depositional features and stratigraphic sections in granitic plutons: implications for the emplacement and crystallization of granitic magma

NASA Astrophysics Data System (ADS)

Wiebe, R. A.; Collins, W. J.

1998-09-01

Many granitic plutons contain sheet-like masses of dioritic to gabbroic rocks or swarms of mafic to intermediate enclaves which represent the input of higher temperature, more mafic magma during crystallization of the granitic plutons. Small-scale structures associated with these bodies (e.g. load-cast and compaction features, silicic pipes extending from granitic layers into adjacent gabbroic sheets) indicate that the sheets and enclave swarms were deposited on a floor of the magma chamber (on granitic crystal mush and beneath crystal-poor magma) while the mafic magma was incompletely crystallized. These structures indicate 'way up', typically toward the interior of the intrusions, and appear to indicate that packages of mafic sheets and enclave concentrations in these plutons are a record of sequential deposition. Hence, these plutons preserve a stratigraphic history of events involved in the construction (filling, replenishment) and crystallization of the magma chamber. The distinctive features of these depositional portions of plutons allow them to be distinguished from sheeted intrusions, which usually preserve mutual intrusive contacts and 'dike-sill' relations of different magma types. The considerable thickness of material that can be interpreted as depositional, and the evidence for replenishment, suggest that magma chamber volumes at any one time were probably much less than the final size of the pluton. Thus, magma chambers may be constructed much more slowly than presently envisaged. The present steep attitudes of these structures in many plutons may have developed gradually as the floor of the chamber (along with the underlying solidified granite and country rock) sank during continuing episodes of magma chamber replenishment. These internal magmatic structures support recent suggestions that the room problem for granites could be largely accommodated by downward movement of country rock beneath the magma chamber.

[Experimental study on the treatment of serious soft tissue injuries with strengthening the spleen and replenishing qi].

PubMed

Chen, Xun-wen; Zhu, Yong-zhan; Chen, Zhi-wei; Wu, Zheng-jie; He, Li-lei

2008-09-01

To study the effects of Chinese drugs based on strengthening the spleen and replenishing qi treatment rule on neoformative capillaries and fibroblast during the soft tissue repair after serious trauma in rats, so as to explore the biological basis of the TCM theory "the spleen dominate extremities and muscles" applied to the treatment of soft tissue injuries. The model rats were established by bleeding from femoral artery and lancing method, and the rats were randomly divided into the control group, strengthening the spleen group and activating blood and resolving stasis group. The samples were got from the tissue of the wounded area at the 5th, 10th and 15th days after oral administration of the traditional Chinese medicine. After fixation and section, the tissues were stained by CD31 and PCNA staining. The amount of the capillaries and fibroblasts in the tissue of the wounded area were observed through multi-purpose microscope (ZEISS Axioskop2). Quantitative analysis was carried out on Image-ProPlus image analyzer. The amount of the capillaries and fibroblasts in the wounded tissue in the strengthening the spleen group were larger than that in the control group at the 5th, 10th and 15th day. And the proliferation speed of capillaries and fibroblasts was faster than those in the control group or the activating blood and resolving stasis group. The Chinese drugs according to strengthening the spleen and replenishing qi treatment rule were effective to promote growth of the granulation tissue and facilitate healing of the wounded area. And it has better effect than the treatment of promoting blood circulation and removing stasis.

Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.

PubMed

McGreal, Steven R; Bhushan, Bharat; Walesky, Chad; McGill, Mitchell R; Lebofsky, Margitta; Kandel, Sylvie E; Winefield, Robert D; Jaeschke, Hartmut; Zachara, Natasha E; Zhang, Zhen; Tan, Ee Phie; Slawson, Chad; Apte, Udayan

2018-04-01

Overdose of acetaminophen (APAP) results in acute liver failure. We have investigated the role of a posttranslational modification of proteins called O-GlcNAcylation, where the O-GlcNAc transferase (OGT) adds and O-GlcNAcase (OGA) removes a single β-D-N-acetylglucosamine (O-GlcNAc) moiety, in the pathogenesis of APAP-induced liver injury. Hepatocyte-specific OGT knockout mice (OGT KO), which have reduced O-GlcNAcylation, and wild-type (WT) controls were treated with 300 mg/kg APAP and the development of injury was studied over a time course from 0 to 24 h. OGT KO mice developed significantly lower liver injury as compared with WT mice. Hepatic CYP2E1 activity and glutathione (GSH) depletion following APAP treatment were not different between WT and OGT KO mice. However, replenishment of GSH and induction of GSH biosynthesis genes were significantly faster in the OGT KO mice. Next, male C57BL/6 J mice were treated Thiamet-G (TMG), a specific inhibitor of OGA to induce O-GlcNAcylation, 1.5 h after APAP administration and the development of liver injury was studied over a time course of 0-24 h. TMG-treated mice exhibited significantly higher APAP-induced liver injury. Treatment with TMG did not affect hepatic CYP2E1 levels, GSH depletion, APAP-protein adducts, and APAP-induced mitochondrial damage. However, GSH replenishment and GSH biosynthesis genes were lower in TMG-treated mice after APAP overdose. Taken together, these data indicate that induction in cellular O-GlcNAcylation exacerbates APAP-induced liver injury via dysregulation of hepatic GSH replenishment response.

Algivore or Phototroph? Plakobranchus ocellatus (Gastropoda) Continuously Acquires Kleptoplasts and Nutrition from Multiple Algal Species in Nature

PubMed Central

Maeda, Taro; Hirose, Euichi; Chikaraishi, Yoshito; Kawato, Masaru; Takishita, Kiyotaka; Yoshida, Takao; Verbruggen, Heroen; Tanaka, Jiro; Shimamura, Shigeru; Takaki, Yoshihiro; Tsuchiya, Masashi; Iwai, Kenji; Maruyama, Tadashi

2012-01-01

The sea slug Plakobranchus ocellatus (Sacoglossa, Gastropoda) retains photosynthetically active chloroplasts from ingested algae (functional kleptoplasts) in the epithelial cells of its digestive gland for up to 10 months. While its feeding behavior has not been observed in natural habitats, two hypotheses have been proposed: 1) adult P. ocellatus uses kleptoplasts to obtain photosynthates and nutritionally behaves as a photoautotroph without replenishing the kleptoplasts; or 2) it behaves as a mixotroph (photoautotroph and herbivorous consumer) and replenishes kleptoplasts continually or periodically. To address the question of which hypothesis is more likely, we examined the source algae for kleptoplasts and temporal changes in kleptoplast composition and nutritional contribution. By characterizing the temporal diversity of P. ocellatus kleptoplasts using rbcL sequences, we found that P. ocellatus harvests kleptoplasts from at least 8 different siphonous green algal species, that kleptoplasts from more than one species are present in each individual sea slug, and that the kleptoplast composition differs temporally. These results suggest that wild P. ocellatus often feed on multiple species of siphonous algae from which they continually obtain fresh chloroplasts. By estimating the trophic position of wild and starved P. ocellatus using the stable nitrogen isotopic composition of amino acids, we showed that despite the abundance of kleptoplasts, their photosynthates do not contribute greatly to the nutrition of wild P. ocellatus, but that kleptoplast photosynthates form a significant source of nutrition for starved sea slugs. The herbivorous nature of wild P. ocellatus is consistent with insights from molecular analyses indicating that kleptoplasts are frequently replenished from ingested algae, leading to the conclusion that natural populations of P. ocellatus do not rely on photosynthesis but mainly on the digestion of ingested algae. PMID:22848693

48 CFR 217.7504 - Acquisition of parts when data is not available.

Code of Federal Regulations, 2012 CFR

2012-10-01

... data is not available. 217.7504 Section 217.7504 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Acquisition of Replenishment Parts 217.7504 Acquisition of parts when data is not...

48 CFR 217.7504 - Acquisition of parts when data is not available.

Code of Federal Regulations, 2011 CFR

2011-10-01

... data is not available. 217.7504 Section 217.7504 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Acquisition of Replenishment Parts 217.7504 Acquisition of parts when data is not...

48 CFR 217.7504 - Acquisition of parts when data is not available.

Code of Federal Regulations, 2010 CFR

2010-10-01

... data is not available. 217.7504 Section 217.7504 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Acquisition of Replenishment Parts 217.7504 Acquisition of parts when data is not...

48 CFR 217.7504 - Acquisition of parts when data is not available.

Code of Federal Regulations, 2013 CFR

2013-10-01

... data is not available. 217.7504 Section 217.7504 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Acquisition of Replenishment Parts 217.7504 Acquisition of parts when data is not...

48 CFR 217.7504 - Acquisition of parts when data is not available.

Code of Federal Regulations, 2014 CFR

2014-10-01

... data is not available. 217.7504 Section 217.7504 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Acquisition of Replenishment Parts 217.7504 Acquisition of parts when data is not...

Precipitation Matters

ERIC Educational Resources Information Center

McDuffie, Thomas

2007-01-01

Although weather, including its role in the water cycle, is included in most elementary science programs, any further examination of raindrops and snowflakes is rare. Together rain and snow make up most of the precipitation that replenishes Earth's life-sustaining fresh water supply. When viewed individually, raindrops and snowflakes are quite…

78 FR 4133 - Procurement List; Proposed Additions and Deletion

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... specific tasks including preparation of menu boards, table bussing service, guest flow rate, service of food, replenishing of food, unloading, storing, and shelving of supplies, food preparation, cashier... the event of contingency, perform all required tasks to include cooking to ensure continued service...

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

PubMed Central

Gossel, Graeme; Hogan, Thea; Cownden, Daniel

2017-01-01

Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to the maintenance of memory compartments. Here, we characterise the kinetics and structure of murine CD4 T cell memory subsets by measuring the rates of influx of new cells and using detailed timecourses of DNA labelling that also distinguish the behaviour of recently divided and quiescent cells. We find that both effector and central memory CD4 T cells comprise subpopulations with highly divergent rates of turnover, and show that inflows of new cells sourced from the naive pool strongly impact estimates of memory cell lifetimes and division rates. We also demonstrate that the maintenance of CD4 T cell memory subsets in healthy mice is unexpectedly and strikingly reliant on this replenishment. DOI: http://dx.doi.org/10.7554/eLife.23013.001 PMID:28282024

Frequent Replenishment Sustains the Beneficial Microbiome of Drosophila melanogaster

PubMed Central

Blum, Jessamina E.; Fischer, Caleb N.; Miles, Jessica; Handelsman, Jo

2013-01-01

ABSTRACT We report that establishment and maintenance of the Drosophila melanogaster microbiome depend on ingestion of bacteria. Frequent transfer of flies to sterile food prevented establishment of the microbiome in newly emerged flies and reduced the predominant members, Acetobacter and Lactobacillus spp., by 10- to 1,000-fold in older flies. Flies with a normal microbiome were less susceptible than germfree flies to infection by Serratia marcescens and Pseudomonas aeruginosa. Augmentation of the normal microbiome with higher populations of Lactobacillus plantarum, a Drosophila commensal and probiotic used in humans, further protected the fly from infection. Replenishment represents an unexplored strategy by which animals can sustain a gut microbial community. Moreover, the population behavior and health benefits of L. plantarum resemble features of certain probiotic bacteria administered to humans. As such, L. plantarum in the fly gut may serve as a simple model for dissecting the population dynamics and mode of action of probiotics in animal hosts. PMID:24194543

The good and bad of being fair: effects of procedural and interpersonal justice behaviors on regulatory resources.

PubMed

Johnson, Russell E; Lanaj, Klodiana; Barnes, Christopher M

2014-07-01

The justice literature has paid considerable attention to the beneficial effects of fair behaviors for recipients of such behaviors. It is possible, however, that exhibiting fair behaviors may come at a cost for actors. In this article, we integrate ego depletion theory with organizational justice research in order to examine the consequences of justice behaviors for actors. We used an experience-sampling method in a sample of managerial employees to examine the relations of performing procedural justice and interpersonal justice behaviors with subsequent changes in actors' regulatory resources. Our results indicate that procedural justice behaviors are draining, whereas interpersonal justice behaviors are replenishing for actors. Depletion, in turn, adversely affected the performance of citizenship behavior, and depletion mediated relations of justice behavior with citizenship. Furthermore, 2 traits that impact self-regulatory skills--extraversion and neuroticism--moderated the replenishing effects of engaging in interpersonal justice behaviors. We conclude by discussing implications and avenues for future research.

The synaptic ribbon is critical for sound encoding at high rates and with temporal precision

PubMed Central

Chakrabarti, Rituparna; Picher, Maria Magdalena; Neef, Jakob; Jung, SangYong; Gültas, Mehmet; Maxeiner, Stephan

2018-01-01

We studied the role of the synaptic ribbon for sound encoding at the synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in mice lacking RIBEYE (RBEKO/KO). Electron and immunofluorescence microscopy revealed a lack of synaptic ribbons and an assembly of several small active zones (AZs) at each synaptic contact. Spontaneous and sound-evoked firing rates of SGNs and their compound action potential were reduced, indicating impaired transmission at ribbonless IHC-SGN synapses. The temporal precision of sound encoding was impaired and the recovery of SGN-firing from adaptation indicated slowed synaptic vesicle (SV) replenishment. Activation of Ca2+-channels was shifted to more depolarized potentials and exocytosis was reduced for weak depolarizations. Presynaptic Ca2+-signals showed a broader spread, compatible with the altered Ca2+-channel clustering observed by super-resolution immunofluorescence microscopy. We postulate that RIBEYE disruption is partially compensated by multi-AZ organization. The remaining synaptic deficit indicates ribbon function in SV-replenishment and Ca2+-channel regulation. PMID:29328020

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels.

PubMed

Gossel, Graeme; Hogan, Thea; Cownden, Daniel; Seddon, Benedict; Yates, Andrew J

2017-03-10

Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to the maintenance of memory compartments. Here, we characterise the kinetics and structure of murine CD4 T cell memory subsets by measuring the rates of influx of new cells and using detailed timecourses of DNA labelling that also distinguish the behaviour of recently divided and quiescent cells. We find that both effector and central memory CD4 T cells comprise subpopulations with highly divergent rates of turnover, and show that inflows of new cells sourced from the naive pool strongly impact estimates of memory cell lifetimes and division rates. We also demonstrate that the maintenance of CD4 T cell memory subsets in healthy mice is unexpectedly and strikingly reliant on this replenishment.

Application of particle swarm optimisation for solving deteriorating inventory model with fluctuating demand and controllable deterioration rate

NASA Astrophysics Data System (ADS)

Chen, Yu-Ren; Dye, Chung-Yuan

2013-06-01

In most of the inventory models in the literature, the deterioration rate of goods is viewed as an exogenous variable, which is not subject to control. In the real market, the retailer can reduce the deterioration rate of product by making effective capital investment in storehouse equipments. In this study, we formulate a deteriorating inventory model with time-varying demand by allowing preservation technology cost as a decision variable in conjunction with replacement policy. The objective is to find the optimal replenishment and preservation technology investment strategies while minimising the total cost over the planning horizon. For any given feasible replenishment scheme, we first prove that the optimal preservation technology investment strategy not only exists but is also unique. Then, a particle swarm optimisation is coded and used to solve the nonlinear programming problem by employing the properties derived from this article. Some numerical examples are used to illustrate the features of the proposed model.

Achieving Stable Radiation Pressure Acceleration of Heavy Ions via Successive Electron Replenishment from Ionization of a High-Z Material Coating.

PubMed

Shen, X F; Qiao, B; Zhang, H; Kar, S; Zhou, C T; Chang, H X; Borghesi, M; He, X T

2017-05-19

A method to achieve stable radiation pressure acceleration (RPA) of heavy ions from laser-irradiated ultrathin foils is proposed, where a high-Z material coating in front is used. The coated high-Z material, acting as a moving electron repository, continuously replenishes the accelerating heavy ion foil with comoving electrons in the light-sail acceleration stage due to its successive ionization under laser fields with Gaussian temporal profile. As a result, the detrimental effects such as foil deformation and electron loss induced by the Rayleigh-Taylor-like and other instabilities in RPA are significantly offset and suppressed so that stable acceleration of heavy ions are maintained. Particle-in-cell simulations show that a monoenergetic Al^{13+} beam with peak energy 3.8 GeV and particle number 10^{10} (charge >20  nC) can be obtained at intensity 10^{22}  W/cm^{2}.

Ion Densities in the Nightside Ionosphere of Mars: Effects of Electron Impact Ionization

NASA Astrophysics Data System (ADS)

Girazian, Z.; Mahaffy, P.; Lillis, R. J.; Benna, M.; Elrod, M.; Fowler, C. M.; Mitchell, D. L.

2017-11-01

We use observations from the Mars Atmosphere and Volatile EvolutioN (MAVEN) mission to show how superthermal electron fluxes and crustal magnetic fields affect ion densities in the nightside ionosphere of Mars. We find that due to electron impact ionization, high electron fluxes significantly increase the CO2+, O+, and O2+ densities below 200 km but only modestly increase the NO+ density. High electron fluxes also produce distinct peaks in the CO2+, O+, and O2+ altitude profiles. We also find that superthermal electron fluxes are smaller near strong crustal magnetic fields. Consequently, nightside ion densities are also smaller near strong crustal fields because they decay without being replenished by electron impact ionization. Furthermore, the NO+/O2+ ratio is enhanced near strong crustal fields because, in the absence of electron impact ionization, O2+ is converted into NO+ and not replenished. Our results show that electron impact ionization is a significant source of CO2+, O+, and O2+ in the nightside ionosphere of Mars.

Abundance and composition of juvenile corals reveals divergent trajectories for coral assemblages across the United Arab Emirates.

PubMed

Pratchett, Morgan S; Baird, Andrew H; Bauman, Andrew G; Burt, John A

2017-01-30

Marked shifts in the composition of coral assemblages are occurring at many locations, but it is unknown whether these are permanent shifts reinforced by patterns of population replenishment. This study examined the composition of juvenile coral assemblages across the United Arab Emirates (UAE). Densities of juvenile corals varied significantly among locations, but were highest where coral cover was highest. Juvenile coral assemblages within the Persian Gulf were dominated by Porites, while no Acropora were recorded. We expect therefore, continued declines in Acropora abundance, while observed dominance of Porites is likely to persist. In the Oman Sea, Pocillopora was the dominant juvenile coral, with Acropora and Stylophora also recorded. This study shows that taxonomic differences in replenishment are reinforcing temporal shifts in coral composition within the southern Persian Gulf, but not in the Oman Sea. Differences in environmental conditions and disturbance regimes likely explain the divergent responses between regions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Superfluid helium on orbit transfer (SHOOT)

NASA Technical Reports Server (NTRS)

Dipirro, Michael J.

1987-01-01

A number of space flight experiments and entire facilities require superfluid helium as a coolant. Among these are the Space Infrared Telescope Facility (SIRTF), the Large Deployable Reflector (LDR), the Advanced X-ray Astrophysics Facility (AXAF), the Particle Astrophysics Magnet Facility (PAMF or Astromag), and perhaps even a future Hubble Space Telescope (HST) instrument. Because these systems are required to have long operational lifetimes, a means to replenish the liquid helium, which is exhausted in the cooling process, is required. The most efficient method of replenishment is to refill the helium dewars on orbit with superfluid helium (liquid helium below 2.17 Kelvin). To develop and prove the technology required for this liquid helium refill, a program of ground and flight testing was begun. The flight demonstration is baselined as a two flight program. The first, described in this paper, will prove the concepts involved at both the component and system level. The second flight will demonstrate active astronaut involvement and semi-automated operation. The current target date for the first launch is early 1991.

Optimal order policy in response to announced price increase for deteriorating items with limited special order quantity

NASA Astrophysics Data System (ADS)

Ouyang, Liang-Yuh; Wu, Kun-Shan; Yang, Chih-Te; Yen, Hsiu-Feng

2016-02-01

When a supplier announces an impending price increase due to take effect at a certain time in the future, it is important for each retailer to decide whether to purchase additional stock to take advantage of the present lower price. This study explores the possible effects of price increases on a retailer's replenishment policy when the special order quantity is limited and the rate of deterioration of the goods is assumed to be constant. The two situations discussed in this study are as follows: (1) when the special order time coincides with the retailer's replenishment time and (2) when the special order time occurs during the retailer's sales period. By analysing the total cost savings between special and regular orders during the depletion time of the special order quantity, the optimal order policy for each situation can be determined. We provide several numerical examples to illustrate the theories in practice. Additionally, we conduct a sensitivity analysis on the optimal solution with respect to the main parameters.

Dietary Supplements for Health, Adaptation, and Recovery in Athletes.

PubMed

Rawson, Eric S; Miles, Mary P; Larson-Meyer, D Enette

2018-03-01

Some dietary supplements are recommended to athletes based on data that supports improved exercise performance. Other dietary supplements are not ergogenic per se, but may improve health, adaptation to exercise, or recovery from injury, and so could help athletes to train and/or compete more effectively. In this review, we describe several dietary supplements that may improve health, exercise adaptation, or recovery. Creatine monohydrate may improve recovery from and adaptation to intense training, recovery from periods of injury with extreme inactivity, cognitive processing, and reduce severity of or enhance recovery from mild traumatic brain injury (mTBI). Omega 3-fatty acid supplementation may also reduce severity of or enhance recovery from mTBI. Replenishment of vitamin D insufficiency or deficiency will likely improve some aspects of immune, bone, and muscle health. Probiotic supplementation can reduce the incidence, duration, and severity of upper respiratory tract infection, which may indirectly improve training or competitive performance. Preliminary data show that gelatin and/or collagen may improve connective tissue health. Some anti-inflammatory supplements, such as curcumin or tart cherry juice, may reduce inflammation and possibly delayed onset muscle soreness (DOMS). Beta-hydroxy beta-methylbutyrate (HMB) does not consistently increase strength and/or lean mass or reduce markers of muscle damage, but more research on recovery from injury that includes periods of extreme inactivity is needed. Several dietary supplements, including creatine monohydrate, omega 3-fatty acids, vitamin D, probiotics, gelatin, and curcumin/tart cherry juice could help athletes train and/or compete more effectively.

Comprehensive summary of beach renourishment and offshore sand removal impacts for Florida

USGS Publications Warehouse

Demopoulos, A.W.J.; Gualtieri, D.J.; Neils, A.; Huge, D.

2011-01-01

An essential first step in the scope of environmental impacts for a sediment mining project is a formulation of specific purpose, precise needs, and estimated impacts. For each individual project, scope must be described, acceptable alternatives must be determined, critical environmental issues must be identified, and mitigation measures must be resolved. Appropriate Federal and State regulations will often require evidence that sand placement is a reasonable alternative to shoreline protection. If so, material to be extracted from the borrow site must be characterized. Candidates must identify the extent of the potential area for sand resources, complete with screening criteria, and site-specific information must be obtained. Alternatives must be identified, compared, and contrasted. And, importantly, the most cost-effective and environmentally sound approach must be determined for the project to move forward. Florida's beaches and coastlines once provided natural protection against storm damage, while simultaneously supporting aquatic ecosystems and both commercial and recreational fisheries. However, beach erosion associated with regional construction and development of the coastline has reduced the effectiveness of natural storm protection. Coastal beaches are, in geological terms, ever-shifting and evolving through natural processes of erosion and replenishment. With permanent structures in place, such as seawalls, jetties, and revetments, natural shoreline is compartmentalized, dynamics are interrupted, and sediment is no longer replenished. Coastal erosion is often a problem where the natural sediment source is deficient. Many of Florida's beaches are now in need of beach replenishment to reduce the high level of damage caused by coastal flooding. Strategic placement of beach fill is a logical means for improving the stability of a shoreline where such a project is economically and environmentally feasible. Sand placement effectively extends the shoreline and provides protection for coastal developments. Beach nourishment or restoration must, however, be thought of as a continual effort and not a one-time fix. Therefore, a combination of sand placement with other erosion mitigation measures can be an effective way to stabilize a shoreline and extend the life of the beach nourishment. Fill material can be obtained from an offshore borrow site, and its characteristics must match the native material in terms of grain size and structure. Environmental concerns for such an effort include potential for decreased water quality during dredging operations, and disturbance of coastal habitat while removing or depositing dredged material. An in-depth scientific evaluation of deposit sites and potential borrow sites must be executed. Mitigation and monitoring efforts will also be critical for a successful low-impact beach management project. The potential exists for unwanted consequences to develop during dredging operations, all of which must be considered and reduced.-->

Low cost solar array project: Cell and module formation research area. Process research of non-CZ silicon material

NASA Technical Reports Server (NTRS)

1983-01-01

Meniscus coates tests, back junction formation using a new boron containing liquid, tests of various SiO2 and boron containing liquids, pelletized silicon for replenishment during web growth, and ion implantation compatibility/feasibility study are discussed.

41 CFR 109-27.102-50 - Systems contracting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Systems contracting. 109... Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102-50 Systems contracting. Systems contracting may...

41 CFR 109-27.102-50 - Systems contracting.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Systems contracting. 109... Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102-50 Systems contracting. Systems contracting may...

Books for Summer Reading.

ERIC Educational Resources Information Center

Phi Delta Kappan, 1991

1991-01-01

To help replenish educators' supply of ideas, "Kappan" editors suggest several books for summer reading, including many noncurrent titles not specifically on education such as Peter Novick's "That Noble Dream," Joy Kogawa's "Obasan," Zora Neale Hurston's "Their Eyes Were Watching God," Kate Chopin's "The Awakening," Willa Cather's "My Antonia,"…

Evaluation and testing of a lightweight fine aggregate concrete bridge deck in Buchanan County, Iowa : tech transfer summaries.

DOT National Transportation Integrated Search

2016-05-01

Using saturated lightweight fine aggregate (LWFA) in concrete mixtures : can replenish water that is depleted during cement hydration without : influencing the water-to-cement (w/c) ratio. This process, known as : internal curing (IC), can contribute...

Monitoring wetland inundation dynamics in response to weather variability in the Chesapeake Bay watershed

USDA-ARS?s Scientific Manuscript database

Wetlands provide a broad range of ecosystem services, including flood control, water purification, groundwater replenishment, and biodiversity support. The provision of these services, which are especially valued in the Chesapeake Bay Watershed, is largely controlled by varying levels of wetness. ...

Fund Education, Shape the Future: Case for Investment. Replenishment 2020

ERIC Educational Resources Information Center

Global Partnership for Education, 2017

2017-01-01

The Global Partnership for Education (GPE) is the only multilateral partnership and fund dedicated exclusively to education in the world's poorest countries. The partnership includes developing country partners, donor countries, multilateral agencies, civil society, teachers, philanthropic foundations and the private sector. GPE brings together…

Automation of irrigation systems to control irrigation applications and crop water use efficiency

USDA-ARS?s Scientific Manuscript database

Agricultural irrigation management to slow water withdrawals from non-replenishing quality water resources is a global endeavor and vital to sustaining irrigated agriculture and dependent rural economies. Research in site-specific irrigation management has shown that water use efficiency, and crop p...

Space Robotics: AWIMR an Overview

NASA Technical Reports Server (NTRS)

Wagner, Rick

2006-01-01

This viewgraph presentation reviews the usages of Autonomous Walking Inspection and Maintenance Robots (AWIMR) in space. Some of the uses that these robots in support of space exploration can have are: inspection of a space craft, cleaning, astronaut assistance, assembly of a structure, repair of structures, and replenishment of supplies.

Logistics Handbook, 1976. Colorado Outward Bound School.

ERIC Educational Resources Information Center

Colorado Outward Bound School, Denver.

Logistics, a support mission, is vital to the successful operation of the Colorado Outward Bound School (COBS) courses. Logistics is responsible for purchasing, maintaining, transporting, and replenishing a wide variety of items, i.e., food, mountaineering and camping equipment, medical and other supplies, and vehicles. The Logistics coordinator…

Ca2+ influx in the endothelial cells is required for the bradykinin-induced endothelium-dependent contraction in the porcine interlobar renal artery

PubMed Central

Ihara, Eikichi; Derkach, Dmitry N; Hirano, Katsuya; Nishimura, Junji; Nawata, Hajime; Kanaide, Hideo

2001-01-01

To determine the mechanism of bradykinin-induced production of endothelium-derived contracting factors, we monitored the changes in cytosolic Ca2+ concentration ([Ca2+]i) in in situ endothelial cells in porcine aortic valvular strips and the changes in [Ca2+]i of smooth muscle cells and force in porcine interlobar renal arterial strips using front-surface fluorometry of fura-2. In the presence of Nω-nitro-l-arginine methyl ester, bradykinin caused an endothelium-dependent transient elevation of [Ca2+]i and contraction in smooth muscle in the interlobar renal artery. This contraction was completely inhibited by a prostaglandin H2/thromboxane A2 receptor antagonist. In the absence of extracellular Ca2+, bradykinin failed to induce contraction. However, replenishing extracellular Ca2+ to 0.75 mm and higher induced an instantaneous contraction. However, replenishing Ca2+per se did not induce any contraction in the absence of bradykinin. Pretreatment with either 10−5m 1-(β-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenethyl)-1H-imidazole hydrochloride (SKF96365) or 0.2 mm Ni2+ abolished the contraction induced by bradykinin in the presence of extracellular Ca2+. Treatment with 10−5m indomethacin completely inhibited the contractile response induced by Ca2+ replenishment, regardless of the timing of its application, before or after the application of bradykinin. In endothelial cells in the valvular strips, bradykinin caused a transient [Ca2+]i elevation in the presence of 1.25 mm extracellular Ca2+, but [Ca2+]i returned to the resting level within 10 min. Neither 10−5m SKF96365 nor 0.2 mm Ni2+ had any effect on the peak [Ca2+]i elevation, but decreased [Ca2+]i in the declining phase. In the absence of extracellular Ca2+, bradykinin induced a transient [Ca2+]i elevation to a level similar to that seen in the presence of 1.25 mm extracellular Ca2+. However, [Ca2+]i then rapidly returned to the prestimulation level within 5 min. Subsequent Ca2+ replenishment to 0.75 mm and higher in the presence of bradykinin elevated [Ca2+]i to significantly higher levels than the resting level seen in the media containing 1.25 mm Ca2+. In conclusion, Ca2+ influx in the endothelial cells is essential for bradykinin to induce endothelium-dependent contraction in the porcine interlobar renal artery. PMID:11483701

Increasing accuracy in the interval analysis by the improved format of interval extension based on the first order Taylor series

NASA Astrophysics Data System (ADS)

Li, Yi; Xu, Yan Long

2018-05-01

When the dependence of the function on uncertain variables is non-monotonic in interval, the interval of function obtained by the classic interval extension based on the first order Taylor series will exhibit significant errors. In order to reduce theses errors, the improved format of the interval extension with the first order Taylor series is developed here considering the monotonicity of function. Two typical mathematic examples are given to illustrate this methodology. The vibration of a beam with lumped masses is studied to demonstrate the usefulness of this method in the practical application, and the necessary input data of which are only the function value at the central point of interval, sensitivity and deviation of function. The results of above examples show that the interval of function from the method developed by this paper is more accurate than the ones obtained by the classic method.

Continuous electrophoretic purification of individual analytes from multicomponent mixtures.

PubMed

McLaren, David G; Chen, David D Y

2004-04-15

Individual analytes can be isolated from multicomponent mixtures and collected in the outlet vial by carrying out electrophoretic purification through a capillary column. Desired analytes are allowed to migrate continuously through the column under the electric field while undesired analytes are confined to the inlet vial by application of a hydrodynamic counter pressure. Using pressure ramping and buffer replenishment techniques, 18% of the total amount present in a bulk sample can be purified when the resolution to the adjacent peak is approximately 3. With a higher resolution, the yield could be further improved. Additionally, by periodically introducing fresh buffer into the sample, changes in pH and conductivity can be mediated, allowing higher purity (>or=99.5%) to be preserved in the collected fractions. With an additional reversed cycle of flow counterbalanced capillary electrophoresis, any individual component in a sample mixture can be purified providing it can be separated in an electrophoresis system.

Studies on crude oil removal from pebbles by the application of biodiesel.

PubMed

Xia, Wen-xiang; Xia, Yan; Li, Jin-cheng; Zhang, Dan-feng; Zhou, Qing; Wang, Xin-ping

2015-02-15

Oil residues along shorelines are hard to remove after an oil spill. The effect of biodiesel to eliminate crude oil from pebbles alone and in combination with petroleum degrading bacteria was investigated in simulated systems. Adding biodiesel made oil detach from pebbles and formed oil-biodiesel mixtures, most of which remained on top of seawater. The total petroleum hydrocarbon (TPH) removal efficiency increased with biodiesel quantities but the magnitude of augment decreased gradually. When used with petroleum degrading bacteria, the addition of biodiesel (BD), nutrients (NUT) and BD+NUT increased the dehydrogenase activity and decreased the biodegradation half lives. When BD and NUT were replenished at the same time, the TPH removal efficiency was 7.4% higher compared to the total improvement of efficiency when BD and NUT was added separately, indicating an additive effect of biodiesel and nutrients on oil biodegradation. Copyright © 2014 Elsevier Ltd. All rights reserved.

The EPQ model under conditions of two levels of trade credit and limited storage capacity in supply chain management

NASA Astrophysics Data System (ADS)

Chung, Kun-Jen

2013-09-01

An inventory problem involves a lot of factors influencing inventory decisions. To understand it, the traditional economic production quantity (EPQ) model plays rather important role for inventory analysis. Although the traditional EPQ models are still widely used in industry, practitioners frequently question validities of assumptions of these models such that their use encounters challenges and difficulties. So, this article tries to present a new inventory model by considering two levels of trade credit, finite replenishment rate and limited storage capacity together to relax the basic assumptions of the traditional EPQ model to improve the environment of the use of it. Keeping in mind cost-minimisation strategy, four easy-to-use theorems are developed to characterise the optimal solution. Finally, the sensitivity analyses are executed to investigate the effects of the various parameters on ordering policies and the annual total relevant costs of the inventory system.

Ribose in the heart.

PubMed

Herrick, James; St Cyr, John

2008-01-01

Every cell needs energy, i.e., adenosine triphosphate (ATP), to carry out its function. Decreased oxygen levels, decreased blood flow, and other stressful conditions can drastically effect the intracellular concentrations of these energy compounds. Skeletal muscle, unlike the heart, can address this drop in ATP by employing the myokinase reaction, ultimately producing ATP with a subsequent elevation in adenosine monophosphate (AMP). Ribose, a naturally occurring 5-carbon monosaccharide, is a key component of RNA, DNA (which has deoxyribose), acetyl coenzyme A, and ATP. Each cell produces its own ribose, involved in the pentose phosphate pathway (PPP), to aid in ATP production. States of ischemia and/or hypoxia can severely lower levels of cellular energy compounds in the heart, with an associated compromise in cellular processes, ultimately reflected in altered function. Ribose appears to provide a solution to the problem in replenishing the depressed ATP levels and improving functional status of patients afflicted with cardiovascular diseases.

Tear exchange and contact lenses: A review

PubMed Central

Muntz, Alex; Subbaraman, Lakshman N.; Sorbara, Luigina; Jones, Lyndon

2015-01-01

Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design innovations have been proposed, but no substantial improvement in soft lens tear exchange has been reported. Researchers have determined post-lens tear exchange using several methods, notably fluorophotometry. However, due to technological limitations, little remains known about tear hydrodynamics around the lens and, to-date, true tear exchange with contact lenses has not been shown. Further knowledge regarding tear exchange could be vital in aiding better contact lens design, with the prospect of alleviating certain adverse ocular responses. This article reviews the literature to-date on the significance, implications and measurement of tear exchange with contact lenses. PMID:25575892

Towards Holistic Heart Failure Management-How to Tackle the Iron Deficiency Epidemic?

PubMed

Van Aelst, Lucas N L; Mazure, Dominiek; Cohen-Solal, Alain

2017-08-01

Heart failure (HF) is a common, costly, disabling, and deadly clinical syndrome and often associated with one or several co-morbidities complicating its treatment or worsening its symptoms. During the last decade, iron deficiency (ID) got recognized as a frequent, debilitating yet easily treatable co-morbidity in HF. In this review, we focus on new evidence that emerged during the last 5 years and discuss the epidemiology, the causes, and the clinical consequences of ID in HF. Apart from replenishing iron stores, intravenous iron improves patients' symptoms, perceived quality of life (QoL), exercise capacity, and hospitalization rates. These beneficial effects cannot be attributed to oral iron, as increased hepcidin levels, typical in inflammatory states such as HF, preclude resorption of iron from the gut. Intravenous iron is the only valid treatment option for ID in HF. However, there are several burning research questions and gaps in evidence remaining in this research field.

Cueing listeners to attend to a target talker progressively improves word report as the duration of the cue-target interval lengthens to 2,000 ms.

PubMed

Holmes, Emma; Kitterick, Padraig T; Summerfield, A Quentin

2018-04-25

Endogenous attention is typically studied by presenting instructive cues in advance of a target stimulus array. For endogenous visual attention, task performance improves as the duration of the cue-target interval increases up to 800 ms. Less is known about how endogenous auditory attention unfolds over time or the mechanisms by which an instructive cue presented in advance of an auditory array improves performance. The current experiment used five cue-target intervals (0, 250, 500, 1,000, and 2,000 ms) to compare four hypotheses for how preparatory attention develops over time in a multi-talker listening task. Young adults were cued to attend to a target talker who spoke in a mixture of three talkers. Visual cues indicated the target talker's spatial location or their gender. Participants directed attention to location and gender simultaneously ("objects") at all cue-target intervals. Participants were consistently faster and more accurate at reporting words spoken by the target talker when the cue-target interval was 2,000 ms than 0 ms. In addition, the latency of correct responses progressively shortened as the duration of the cue-target interval increased from 0 to 2,000 ms. These findings suggest that the mechanisms involved in preparatory auditory attention develop gradually over time, taking at least 2,000 ms to reach optimal configuration, yet providing cumulative improvements in speech intelligibility as the duration of the cue-target interval increases from 0 to 2,000 ms. These results demonstrate an improvement in performance for cue-target intervals longer than those that have been reported previously in the visual or auditory modalities.

Foreign and Undocumented Workers in California Agriculture.

ERIC Educational Resources Information Center

Taylor, J. Edward; Espenshade, Thomas J.

The Immigration Reform and Control Act of 1986 contains controversial provisions to allow temporary "replenishment" farmworkers to enter the United States to harvest perishable crops. This paper describes the role of legal and illegal foreign workers in California agriculture in relation to these provisions and the assumptions on which…

32 CFR 706.1 - Purpose of regulations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... or blue contour approach lights on replenishment-type ships. These lights may be shown in combination... navigational lights and sound-signalling appliances of some naval vessels may vary from the requirements of the... number, position, range, or arc of visibility of lights, as well as to the disposition and...

32 CFR 706.1 - Purpose of regulations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... or blue contour approach lights on replenishment-type ships. These lights may be shown in combination... navigational lights and sound-signalling appliances of some naval vessels may vary from the requirements of the... number, position, range, or arc of visibility of lights, as well as to the disposition and...

32 CFR 706.1 - Purpose of regulations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... or blue contour approach lights on replenishment-type ships. These lights may be shown in combination... navigational lights and sound-signalling appliances of some naval vessels may vary from the requirements of the... number, position, range, or arc of visibility of lights, as well as to the disposition and...

32 CFR 706.1 - Purpose of regulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... or blue contour approach lights on replenishment-type ships. These lights may be shown in combination... navigational lights and sound-signalling appliances of some naval vessels may vary from the requirements of the... number, position, range, or arc of visibility of lights, as well as to the disposition and...

32 CFR 706.1 - Purpose of regulations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... or blue contour approach lights on replenishment-type ships. These lights may be shown in combination... navigational lights and sound-signalling appliances of some naval vessels may vary from the requirements of the... number, position, range, or arc of visibility of lights, as well as to the disposition and...

77 FR 497 - Control of Emissions From New Nonroad Compression-Ignition Engines: Approval of New Scheduled...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-05

... replenishment of the nitrogen-containing reducing agent for selective catalytic reduction (SCR) technologies... NO X reduction requirements for their diesel engines. SCR systems use a nitrogen-containing reducing... balance between the dictates of operating nonroad equipment (which requires DEF tanks of small enough...

41 CFR 109-27.102-50 - Systems contracting.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102-50 Systems contracting. Systems contracting may... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Systems contracting. 109-27.102-50 Section 109-27.102-50 Public Contracts and Property Management Federal Property Management...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 109-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Economic order quantity principle. 109-27.102 Section 109-27.102 Public Contracts and Property Management Federal Property... PROCUREMENT 27-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102 Economic order quantity principle. ...

Quantifying and mitigating the environmental impacts of using corn stover as a biofuel feedstock

USDA-ARS?s Scientific Manuscript database

Background/Question/Methods Corn stover has been suggested as a viable biomass feedstock for bioenergy production. However, unharvested corn stover provides two important ecosystem services: it reduces soil erosion and replenishes soil carbon, both of which help maintain soil productivity. There are...

Hard Choices: Development of Non-Energy Non-Replenishable Resources. AIO Report No. 10.

ERIC Educational Resources Information Center

Americans for Indian Opportunity, Inc., Albuquerque, NM.

Presenting highlights from a seminar designed to explore the possibilities of "developing minerals in Indian nations by Indian people for the benefit of Indian people", this document includes documentation of the proceedings as follows: (1) Participants Roundtable (participant experiences revealing concern for lack of knowledge,…

75 FR 59899 - Endangered and Threatened Wildlife and Plants: Proposed Rulemaking To Designate Critical Habitat...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

... from Corona Del Mar State Beach to Dana Point, California. DATES: Comments on this proposed rule to...-water discharge, agricultural pesticide application and irrigation, construction and operation of tidal... replenishment, waste-water discharge, coastal development, non-native species introduction and management...

Low Maintenance Water Treatment for Heating and Cooling Systems: Review of Technologies and Guidelines for Implementation

DTIC Science & Technology

2007-09-01

should be operated periodically to replenish inhibitor and bio- cide concentrations and prevent particulate matter from settling and pro- moting under... Cotton , Irvin J. (2000). “On-Line Dissolved Oxygen Monitoring in Boiler Feedwater Systems.” Paper No. 00661. Corrosion 2000. NACE International

Exploring Matter: An Interactive, Inexpensive Chemistry Exhibit for Museums

ERIC Educational Resources Information Center

Murov, Steven; Chavez, Arnold

2017-01-01

Despite its vital importance in our lives, chemistry is inadequately represented in most museums. Issues such as safety, replenishing and disposal of chemicals, supervision required, and cost are constraints that have limited the number and size of chemistry exhibits. Taking into account the constraints, a 21-station interactive and inexpensive…

41 CFR 109-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Economic order quantity principle. 109-27.102 Section 109-27.102 Public Contracts and Property Management Federal Property... PROCUREMENT 27-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102 Economic order quantity principle. ...

41 CFR 109-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Economic order quantity principle. 109-27.102 Section 109-27.102 Public Contracts and Property Management Federal Property... PROCUREMENT 27-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102 Economic order quantity principle. ...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 109-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Economic order quantity principle. 109-27.102 Section 109-27.102 Public Contracts and Property Management Federal Property... PROCUREMENT 27-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102 Economic order quantity principle. ...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 101-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Economic order quantity... MANAGEMENT 27.1-Stock Replenishment § 101-27.102 Economic order quantity principle. The economic order quantity (EOQ) principle is a means for achieving economical inventory management. Application of the EOQ...

41 CFR 109-27.102 - Economic order quantity principle.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Economic order quantity principle. 109-27.102 Section 109-27.102 Public Contracts and Property Management Federal Property... PROCUREMENT 27-INVENTORY MANAGEMENT 27.1-Stock Replenishment § 109-27.102 Economic order quantity principle. ...

41 CFR 101-27.102-3 - Limitations on use.

Code of Federal Regulations, 2011 CFR

2011-07-01

... possible replenishments for a given level of inventory investment; or (2) The lowest possible level of... possession, the economic purchase quantity (EPQ) principle shall be used as described in the GSA Handbook. The Economic Order Quantity Principle and Applications. [29 FR 15997, Dec. 1, 1964, as amended at 31...

A Comparative Study of Online Item Calibration Methods in Multidimensional Computerized Adaptive Testing

ERIC Educational Resources Information Center

Chen, Ping

2017-01-01

Calibration of new items online has been an important topic in item replenishment for multidimensional computerized adaptive testing (MCAT). Several online calibration methods have been proposed for MCAT, such as multidimensional "one expectation-maximization (EM) cycle" (M-OEM) and multidimensional "multiple EM cycles"…

76 FR 9229 - Administration of Copyright Office Deposit Accounts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

... balance in that account; require the closure of a deposit account the second time it is overdrawn within... against the balance instead of sending separate payments with applications and other requests for services... requiring a minimum deposit account balance and optional automatic replenishment discussed herein is a more...

From Oasis to Mirage: The Aquifers That Won't Replenish.

ERIC Educational Resources Information Center

Gardner, Gary

1995-01-01

Tells the story of three fossil aquifers, in Saudi Arabia, Libya, and the United States, that are mined at nonrenewable rates for agricultural irrigation. Examines the consequences of a collision between rising consumption and falling groundwater supplies. Charts Libya's projected water needs compared to renewable supply, 1985-2030. (LZ)

BOLE WATER CONTENT SHOWS LITTLE SEASONAL VARIATION IN CENTURY-OLD DOUGLAS-FIR TREES

EPA Science Inventory

Purportedly, large Douglas-fir trees in the American Pacific Northwest use water stored in bole tissues to ameliorate the effects of seasonal summer drought, the water content of bole tissues being drawn down over the summer months and replenished during the winter. Continuous mo...

Social Work Continuing Education: Current Issues and Future Direction

ERIC Educational Resources Information Center

Kurzman, Paul A.

2016-01-01

Continuing education is arising as an area of rapid growth and increased attention in the social work profession. Conceptually, the impetus and focus are on the promotion of the principles of lifelong learning and professional replenishment; but pragmatically, the driving force has been the virtually universal requirement of continuing education…

Nanoscale modeling for ultrathin liquid films: Spreading and coupled layering

NASA Astrophysics Data System (ADS)

Phillips, David Michael

The hard disk drive (HDD) industry is currently experiencing a compound annual growth rate of 100% for the areal density. Current production drives have an areal density of 80 Gbit in-2, and drives with an areal density of 100 Gbit in-2 have been recently demonstrated. While much of this growth has been fueled by the development of new read/write heads, some of this gain was achieved by reducing the spacing between the heads and the magnetic media. This in turn reduces the spacing at the head-disk interface (HDI). The HDI in a HDD system consists of a slider, which contains the read/write heads, flying over the disk surface on an air bearing. The current designed separation distance, or fly height, is less than 10 nm. This spacing is expected to reduce to a mere 5 nm within the next few years. With the reduced fly height, intermittent contacts at the HDI become more probable. Only a thin lubricant film of perfluoropolyether (PFPE) and a sputtered carbon overcoat on the disk surface protect the slider and the stored data from mechanical and thermal damage. The PFPE film is quite thin, with a thickness of less than 2 nm or about a monolayer of molecules. During an HDI contact, the PFPE film is considered sacrificial and is often depleted in the contact area. In order to maintain adequate protection for the disk surface, PFPE molecules from the surrounding film must replenish the depleted area. This replenishment ability directly opposes the requirement that the PFPE film must not spin-off of the disk surface due to the disk rotation rate, which is as high as 10,000 RPM in current drives. To balance the PFPE films to sufficiently meet both requirements, HDD manufacturers functionalized the endgroups of the PFPE molecules to allow some portion of the lubricant film to reversibly bond with the disk overcoat. The result is a lubricant film that has a slower replenishment but does not spin-off. The work presented here focuses on the replenishment ability of thin films of liquid PFPE. The experimental analogue of replenishment is the one-dimensional spreading analysis. PFPEs with functional endgroups demonstrated coupled molecular layering and dewetting phenomena during the spreading analysis, while PFPEs with nonfunctional endgroups did not. All of the PFPE thin films spread via a diffusive process and had diffusion coefficients that depended on the local film thickness. A theoretical analysis is presented here for both the governing equation and the disjoining pressure driving force for the PFPE thin film spreading. For PFPEs with non-functional endgroups, a reasonable analysis is performed on the diffusion coefficient for two classes of film: submonolayer and multilayer. The diffusion coefficient of PFPEs with functional endgroups are qualitatively linked to the gradient of the film disjoining pressure. To augment this theory, both lattice-based and off-lattice Monte Carlo simulations are conducted for PFPE film models. The lattice-based model shows the existence of a critical functional endgroup interaction strength. It is also used to study the break-up of molecular layers for a spreading film via a fractal analysis. The off-lattice model is used to calculate the anisotropic pressure tensor for the model PFPE thin film and subsequently the film disjoining pressure. The model also qualitatively analyzes of the self diffusion in the film.

High-Intensity Interval Training for Improving Postprandial Hyperglycemia

ERIC Educational Resources Information Center

Little, Jonathan P.; Francois, Monique E.

2014-01-01

High-intensity interval training (HIIT) has garnered attention in recent years as a time-efficient exercise option for improving cardiovascular and metabolic health. New research demonstrates that HIIT may be particularly effective for improving postprandial hyperglycemia in individuals with, or at risk for, type 2 diabetes (T2D). These findings…

Climatic forcing and larval dispersal capabilities shape the replenishment of fishes and their habitat-forming biota on a tropical coral reef.

PubMed

Wilson, Shaun K; Depcyznski, Martial; Fisher, Rebecca; Holmes, Thomas H; Noble, Mae M; Radford, Ben T; Rule, Michael; Shedrawi, George; Tinkler, Paul; Fulton, Christopher J

2018-02-01

Fluctuations in marine populations often relate to the supply of recruits by oceanic currents. Variation in these currents is typically driven by large-scale changes in climate, in particular ENSO (El Nino Southern Oscillation). The dependence on large-scale climatic changes may, however, be modified by early life history traits of marine taxa. Based on eight years of annual surveys, along 150 km of coastline, we examined how ENSO influenced abundance of juvenile fish, coral spat, and canopy-forming macroalgae. We then investigated what traits make populations of some fish families more reliant on the ENSO relationship than others. Abundance of juvenile fish and coral recruits was generally positively correlated with the Southern Oscillation Index (SOI), higher densities recorded during La Niña years, when the ENSO-influenced Leeuwin Current is stronger and sea surface temperature higher. The relationship is typically positive and stronger among fish families with shorter pelagic larval durations and stronger swimming abilities. The relationship is also stronger at sites on the coral back reef, although the strongest of all relationships were among the lethrinids ( r  = .9), siganids ( r  = .9), and mullids ( r  = .8), which recruit to macroalgal meadows in the lagoon. ENSO effects on habitat seem to moderate SOI-juvenile abundance relationship. Macroalgal canopies are higher during La Niña years, providing more favorable habitat for juvenile fish and strengthening the SOI effect on juvenile abundance. Conversely, loss of coral following a La Niña-related heat wave may have compromised postsettlement survival of coral dependent species, weakening the influence of SOI on their abundance. This assessment of ENSO effects on tropical fish and habitat-forming biota and how it is mediated by functional ecology improves our ability to predict and manage changes in the replenishment of marine populations.

Implementing the millennium development food security goals Challenges of the southern African context

NASA Astrophysics Data System (ADS)

Love, David; Twomlow, Steve; Mupangwa, Walter; van der Zaag, Pieter; Gumbo, Bekithemba

The Millennium Development Goals’ target to halve the proportion of people who suffer from hunger is extremely important in southern Africa, where food security has become increasingly problematic over the last 20 years. One “quick-win” proposal is replenishment of soil nutrients for smallholder farmers, through free or subsidised chemical fertilisers. Other proposals include appropriate irrigation technology, improved inputs and interventions targeted at women. Analysis of over 10 years of agro-hydrological and agro-economic studies from southern African show that a different approach is required to interventions proposed. There are sustainability problems with free chemical fertiliser due to transport costs and ancillary costs. Furthermore, recent studies in Zimbabwe and Mozambique show that significant increases in yield can only be obtained when soil fertility management is combined with good crop husbandry, e.g. timely planting and weeding. Ongoing replenishment of fertility would be dependent on a continued free or subsidised fertiliser supply, and transport system. Increasing access to irrigation will help, but is not the only solution and cannot reach even a majority of farmers. It has been determined that short dryspells are often the major cause of low yields in sub-Saharan Africa. Soil-water conservation approaches, e.g. winter weeding and conservation tillage, can reduce risk and increase yield. The following specific recommendations are made for urgent interventions to contribute sustainably to food security in southern Africa: (i) To increases access to fertiliser, consider development of strong input markets at end-user level. (ii) Intensification of technology transfer, focusing on capacity building for transfer of existing technologies and much closer collaboration between state and NGO sectors, agronomists and water engineers. (iii) Increasing the uptake of soil-water conservation methods, including conservation tillage and weeding, and supplementary irrigation to minimise adverse effects of dryspells, through investments in farmer training. (iv) Linking crop development strategies to livestock development practices and strategies. (v) Developing non-agro-based livelihood strategies in marginal lands.

Interval Running Training Improves Cognitive Flexibility and Aerobic Power of Young Healthy Adults.

PubMed

Venckunas, Tomas; Snieckus, Audrius; Trinkunas, Eugenijus; Baranauskiene, Neringa; Solianik, Rima; Juodsnukis, Antanas; Streckis, Vytautas; Kamandulis, Sigitas

2016-08-01

Venckunas, T, Snieckus, A, Trinkunas, E, Baranauskiene, N, Solianik, R, Juodsnukis, A, Streckis, V, and Kamandulis, S. Interval running training improves cognitive flexibility and aerobic power of young healthy adults. J Strength Cond Res 30(8): 2114-2121, 2016-The benefits of regular physical exercise may well extend beyond the reduction of chronic diseases risk and augmentation of working capacity, to many other aspects of human well-being, including improved cognitive functioning. Although the effects of moderate intensity continuous training on cognitive performance are relatively well studied, the benefits of interval training have not been investigated in this respect so far. The aim of the current study was to assess whether 7 weeks of interval running training is effective at improving both aerobic fitness and cognitive performance. For this purpose, 8 young dinghy sailors (6 boys and 2 girls) completed the interval running program with 200 m and 2,000 m running performance, cycling maximal oxygen uptake, and cognitive function was measured before and after the intervention. The control group consisted of healthy age-matched subjects (8 boys and 2 girls) who continued their active lifestyle and were tested in the same way as the experimental group, but did not complete any regular training. In the experimental group, 200 m and 2,000 m running performance and cycling maximal oxygen uptake increased together with improved results on cognitive flexibility tasks. No changes in the results of short-term and working memory tasks were observed in the experimental group, and no changes in any of the measured indices were evident in the controls. In conclusion, 7 weeks of interval running training improved running performance and cycling aerobic power, and were sufficient to improve the ability to adjust behavior to changing demands in young active individuals.

Hardware Design Improvements to the Major Constituent Analyzer

NASA Technical Reports Server (NTRS)

Combs, Scott; Schwietert, Daniel; Anaya, Marcial; DeWolf, Shannon; Merrill, Dave; Gardner, Ben D.; Thoresen, Souzan; Granahan, John; Belcher, Paul; Matty, Chris

2011-01-01

The Major Constituent Analyzer (MCA) onboard the International Space Station (ISS) is designed to monitor the major constituents of the ISS's internal atmosphere. This mass spectrometer based system is an integral part of the Environmental Control and Life Support System (ECLSS) and is a primary tool for the management of ISS atmosphere composition. As a part of NASA Change Request CR10773A, several alterations to the hardware have been made to accommodate improved MCA logistics. First, the ORU 08 verification gas assembly has been modified to allow the verification gas cylinder to be installed on orbit. The verification gas is an essential MCA consumable that requires periodic replenishment. Designing the cylinder for subassembly transport reduces the size and weight of the maintained item for launch. The redesign of the ORU 08 assembly includes a redesigned housing, cylinder mounting apparatus, and pneumatic connection. The second hardware change is a redesigned wiring harness for the ORU 02 analyzer. The ORU 02 electrical connector interface was damaged in a previous on-orbit installation, and this necessitated the development of a temporary fix while a more permanent solution was developed. The new wiring harness design includes flexible cable as well as indexing fasteners and guide-pins, and provides better accessibility during the on-orbit maintenance operation. This presentation will describe the hardware improvements being implemented for MCA as well as the expected improvement to logistics and maintenance.

Adiponectin in Fresh Frozen Plasma Contributes to Restoration of Vascular Barrier Function after Hemorrhagic Shock

PubMed Central

Huby, Maria P.; Duan, Chaojun; Baer, Lisa; Peng, Zhanglong; Kozar, Rosemary A.; Doursout, Marie-Francoise; Holcomb, John B.; Wade, Charles E.; Ko, Tien C.

2015-01-01

Hemorrhagic shock is the leading cause of preventable deaths in civilian and military trauma. Use of fresh frozen plasma (FFP) in patients requiring massive transfusion is associated with improved outcomes. FFP contains significant amounts of adiponectin, which is known to have vascular protective function. We hypothesize that FFP improves vascular barrier function largely via adiponectin. Plasma adiponectin levels were measured in 19 severely injured patients in hemorrhagic shock (HS). Compared to normal individuals, plasma adiponectin levels decreased to 49% in HS patients prior to resuscitation (p<0.05) and increased to 64% post resuscitation (but not significant). In a HS mouse model, we demonstrated a similar decrease in plasma adiponectin to 54% but a significant increase to 79% by FFP resuscitation compared to baseline (p<0.05). HS disrupted lung vascular barrier function, leading to an increase in permeability. FFP resuscitation reversed these HS-induced effects. Immunodepletion of adiponectin from FFP abolished FFP's effects on blocking endothelial hyperpermeability in vitro, and on improving lung vascular barrier function in HS mice. Replenishment with adiponectin rescued FFP's effects. These findings suggest that adiponectin is an important component in FFP resuscitation contributing to the beneficial effects on vascular barrier function after HS. PMID:26263440

Supply chain optimization at an academic medical center.

PubMed

Labuhn, Jonathan; Almeter, Philip; McLaughlin, Christopher; Fields, Philip; Turner, Benjamin

2017-08-01

A successful supply chain optimization project that leveraged technology, engineering principles, and a technician workflow redesign in the setting of a growing health system is described. With continued rises in medication costs, medication inventory management is increasingly important. Proper management of central pharmacy inventory and floor-stock inventory in automated dispensing cabinets (ADCs) can be challenging. In an effort to improve control of inventory costs in the central pharmacy of a large academic medical center, the pharmacy department implemented a supply chain optimization project in collaboration with the medical center's inhouse team of experts on process improvement and industrial engineering. The project had 2 main components: (1) upgrading and reconfiguring carousel technology within an expanded central pharmacy footprint to generate accurate floor-stock inventory replenishment reports, which resulted in efficiencies within the medication-use system, and (2) implementing a technician workflow redesign and algorithm to right-size the ADC inventory, which decreased inventory stockouts (i.e., incidents of depletion of medication stock) and improved ADC user satisfaction. Through a multifaceted approach to inventory management, the number of stockouts per month was decreased and ADC inventory was optimized, resulting in a one-time inventory cost savings of $220,500. Copyright © 2017 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Understanding Attrition in UK Maritime Education and Training

ERIC Educational Resources Information Center

Gekara, Victor

2009-01-01

The shipping industry worldwide is experiencing a shortage of trained and qualified officers to operate a rapidly expanding global merchant fleet. High cadet wastage in Maritime Education and Training (MET) institutions is an obstacle to skills replenishment in the UK. This paper examines the specificity of MET programmes with regard to the…

Online Calibration Methods for the DINA Model with Independent Attributes in CD-CAT

ERIC Educational Resources Information Center

Chen, Ping; Xin, Tao; Wang, Chun; Chang, Hua-Hua

2012-01-01

Item replenishing is essential for item bank maintenance in cognitive diagnostic computerized adaptive testing (CD-CAT). In regular CAT, online calibration is commonly used to calibrate the new items continuously. However, until now no reference has publicly become available about online calibration for CD-CAT. Thus, this study investigates the…

Decision Support System for Aquifer Recharge (AR) and Aquifer Storage and Recovery (ASR) Planning, Design, and Evaluation - Principles and Technical Basis

EPA Science Inventory

Aquifer recharge (AR) is a technical method being utilized to enhance groundwater resources through man-made replenishment means, such as infiltration basins and injections wells. Aquifer storage and recovery (ASR) furthers the AR techniques by withdrawal of stored groundwater at...

Sperm depletion in singly mated females of the Mexican Fruit Fly (Diptera: Tephritidae)

USDA-ARS?s Scientific Manuscript database

Female Mexican fruit flies, or mexflies, have the capacity to produce more than a thousand eggs over their lifetime but fertility of the eggs will depend on the female’s capacity to store semen and/or to replenish semen through remating. The two parameters are interrelated in that sexual receptivity...

40 CFR 63.11507 - What are my standards and management practices?

Code of Federal Regulations, 2014 CFR

2014-07-01

... other bath chemistry ingredients that are added to replenish the bath, as in the original make-up of the... bath. (iii) If a wetting agent/fume suppressant is included in the electrolytic process bath chemicals... practicable. (8) Maintain quality control of chemicals, and chemical and other bath ingredient concentrations...

40 CFR 63.11507 - What are my standards and management practices?

Code of Federal Regulations, 2010 CFR

2010-07-01

... chemistry ingredients that are added to replenish the tank bath, as in the original make-up of the tank. (iii) If a wetting agent/fume suppressant is included in the electrolytic process bath chemicals used... to be plated, as practicable. (8) Maintain quality control of chemicals, and chemical and other bath...

78 FR 34687 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... To Amend Rule 1000-- Equities To Revise the Manner by Which the Exchange Will Phase Out the... Exchange will phase out the functionality associated with liquidity replenishment points (``LRPs'') in... Exchange filed to amend Rule 1000--Equities to provide that it would phase out the functionality associated...

37 CFR 1.23 - Methods of payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... made by credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process... authorization to charge fees to a credit card. If credit card information is provided on a form or document...

12 CFR 701.34 - Designation of low income status; Acceptance of secondary capital accounts by low-income...

Code of Federal Regulations, 2014 CFR

2014-01-01

... under no circumstances restore or replenish those funds to [name of institutional investor]. Dividends.... Accrued interest. By initialing below, [name of credit union] and [name of institutional investor] agree... years, meet the criteria for the designation or come into compliance with the regulatory requirements...

12 CFR 701.34 - Designation of low income status; Acceptance of secondary capital accounts by low-income...

Code of Federal Regulations, 2011 CFR

2011-01-01

... replenish those funds to [name of institutional investor]. Dividends are not considered operating losses and... of credit union] and [name of institutional investor] agree that accrued interest will be: __Paid... designation or come into compliance with the regulatory requirements applicable to federal credit unions that...

37 CFR 1.23 - Methods of payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... made by credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process... authorization to charge fees to a credit card. If credit card information is provided on a form or document...

37 CFR 1.23 - Methods of payment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... made by credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process... authorization to charge fees to a credit card. If credit card information is provided on a form or document...

37 CFR 1.23 - Methods of payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... made by credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process... authorization to charge fees to a credit card. If credit card information is provided on a form or document...

41 CFR 101-27.103 - Acquisition of excess property.

Code of Federal Regulations, 2011 CFR

2011-07-01

... which an economic retention limit has been established in accordance with the provisions of subpart 101-27.3 of this part, inventory levels may be adjusted upward when items of stock are to be acquired... replenishment within an agency an inventory level in excess of 2 years is appropriate for low dollar-volume...

Social Capital by Design: Normative Systems and Social Structures in Six High Schools.

ERIC Educational Resources Information Center

Marks, Helen M.

This paper focuses on investigating the purposive design of learning environments to counter the erosion of social capital in communities and schools in contemporary society. Can schools intentionally replenish stocks of social capital by creating normative systems conducive to the optimal academic and social development of students, and by…

Math Model for Naval Ship Handling Trainer.

ERIC Educational Resources Information Center

Golovcsenko, Igor V.

The report describes the math model for an experimental ship handling trainer. The training task is that of a replenishment operation at sea. The model includes equations for ship dynamics of a destroyer, propeller-engine response times, ship separation, interaction effects between supply ship and destroyer, and outputs to a visual display system.…

75 FR 62345 - Minimum Balance Requirement and Automatic Replenishment Option for Deposit Account Holders

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

... LIBRARY OF CONGRESS Copyright Office 37 CFR Part 201 [Docket No. RM 2009-4] Minimum Balance... transactions per year; require deposit account holders to maintain a minimum balance in that account; mandate... against the balance instead of sending separate payments with applications and other requests for services...

Development of a High Level Architecture Federation of Ship Replenishment at Sea

DTIC Science & Technology

2011-10-01

utiliser une infrastructure de simulation appelée architecture de haut niveau (HLA) afin de fournir des environne - ments de simulation interarmées...fournir un environnement de simulation qui modélise l’interactions entre les divers composants afin de simuler les conditions qui mènent aux

Saving Spaceship Earth: Teaching the Ethics of Environmental Stewardship

ERIC Educational Resources Information Center

Beairsto, Bruce

2009-01-01

Mankind's capacity to consume the earth's resources has overwhelmed nature's capacity to replenish itself, and people are polluting at a rate that nature cannot repair. This road leads inevitably to serious, and potentially fatal consequences. In this article, the author suggests that educators need to go beyond merely enabling students to…

Parametric CERs (Cost Estimate Relationships) for Replenishment Repair Parts (Selected U.S. Army Helicopters and Combat Vehicles)

DTIC Science & Technology

1989-07-31

Information System (OSMIS). The long-range objective is to develop methods to determine total operating and support (O&S) costs within life-cycle cost...objective was to assess the feasibility of developing cost estimating relationships (CERs) based on data from the Army Operating and Support Management

A Compendium of Air Force Institute of Technology Thesis Abstracts Related to Acquisition Management

DTIC Science & Technology

1990-09-01

SHOULD PROGRAM DIRECTORS BE GRANTED CONTRACTING AUTHORITY? Champlain, George F. Sep 89 AD-A216 357 ABSTRACT: In Air Force Systems Command (AFSC...COMPETITIVE PRICES IN THE ACQUISITION OF WEAPON SYSTEM REPLENISHMENT SPARE PARTS. Brost , Edward J, Sep 82 AD-A122 962 ABSTRACT: Competition is the

LOGWAR 15: Analysis Report

DTIC Science & Technology

2016-04-01

Vertical Replenishment VTC Video Teleconference WASH Water, Sanitation, and Hygiene WFP World Food Programme WHO World Health Organization...issues Pa rt ic ip an ts Contexts Combat Disease Refugees Insurgency Natural Disaster Contamination Visibility Disposition Distribution Sourcing...requirements; limited shelf life; used by many actors; often in short supply; restrictions on sourcing; contamination concerns (IV solutions) Small in

California forests: trends, problems, and opportunities.

Treesearch

Charles L. Bolsinger

1980-01-01

The most recent information on forest area in California, volume of timber, ownership of forest resources, and rate of use and replenishment is summarized. An analysis of physical opportunities to increase timber production is presented, along with a discussion of problems relating to timber production. Also included are detailed statistical tables; a brief historical...

75 FR 43488 - Certain Hot-Rolled Carbon Steel Flat Products From India: Final Results of Countervailing Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

.... Export Promotion Capital Goods Scheme (EPCGS) 3. Advance License Program (ALP) 4. Duty Entitlement Passbook Scheme (DEPS) 5. Status Certificate Program 6. Loan Guarantees From the GOI 7. Steel Development... Act: Exemption From the National Service Tax 21. Duty Free Replenishment Certificate (DFRC) Scheme 22...

Hope Replenished: Exceptional Scholarship Strides in Educational Administration

ERIC Educational Resources Information Center

Mullen, Carol A.

2006-01-01

For decades now, critics have viewed educational leadership and administration as sorely lacking in many respects--including as a field of scholarly inquiry. Murphy, Hawley, and Young (2005) cite numerous studies that have "assessed the profession and judged it to be in poor health" (p. 49). Thomas Sergiovanni, another leading scholar,…

A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria.

PubMed

Li, Ke; Zhang, Yang-Yang; Jiang, Guo-Yu; Hou, Yuan-Jun; Zhang, Bao-Wen; Zhou, Qian-Xiong; Wang, Xue-Song

2015-05-07

A piperazine-modified Crystal Violet was found to be able to selectively inactivate Gram-negative bacteria upon visible light irradiation but left Gram-positive bacteria less damaged, which can serve as a blueprint for the development of novel narrow-spectrum agents to replenish the current arsenal of photodynamic antimicrobial chemotherapy (PACT).

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

PubMed Central

Goutman, Juan D; Auclair, Sarah Marie; Boutet de Monvel, Jacques; Tertrais, Margot; Emptoz, Alice; Parrin, Alexandre; Nouaille, Sylvie; Guillon, Marc; Sachse, Martin; Ciric, Danica; Bahloul, Amel; Hardelin, Jean-Pierre; Sutton, Roger Bryan; Avan, Paul; Krishnakumar, Shyam S; Rothman, James E

2017-01-01

Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C2-domain, Ca2+-binding transmembrane protein of synaptic vesicles. To decipher the role of otoferlin in the synaptic vesicle cycle, we produced knock-in mice (Otof Ala515,Ala517/Ala515,Ala517) with lower Ca2+-binding affinity of the C2C domain. The IHC ribbon synapse structure, synaptic Ca2+ currents, and otoferlin distribution were unaffected in these mutant mice, but auditory brainstem response wave-I amplitude was reduced. Lower Ca2+ sensitivity and delay of the fast and sustained components of synaptic exocytosis were revealed by membrane capacitance measurement upon modulations of intracellular Ca2+ concentration, by varying Ca2+ influx through voltage-gated Ca2+-channels or Ca2+ uncaging. Otoferlin thus functions as a Ca2+ sensor, setting the rates of primed vesicle fusion with the presynaptic plasma membrane and synaptic vesicle pool replenishment in the IHC active zone. PMID:29111973

Research on CPFR pattern of the Internet of things based on B2C

NASA Astrophysics Data System (ADS)

Zhou, Ling; Yang, Jie

2013-03-01

The CPFR pattern proposed by this article is based on the internet of things platform, using frontier technology of internet of things to realize real-time monitoring and the feedback in logistics, information stream in B2C mode, and simultaneously construct an e-business mode which takes the customer guidance as the center to be possible to meet the customers' need and realize the service made by customer. This new pattern uses the coordination, plan, prediction and replenishment of CPFR to realize custom-made stock based on B2C for terminal customer and specialized service for commodity stock. Moreover, it can bring suppliers real-time monitoring of terminal logistics, storage and users' notes for use, and feed back users' bugs, adjustment of orders and plan of replenishment. Furthermore, based on new pattern, we can data min users' interests and undertake a study in increment modeling, process reengineering in enterprise, optimizing enterprise's interior resources and conformity industry of supply chain. Above all it provides a new mentality and the operation pattern for the electronic commerce marketing.

Precision replenishable grinding tool and manufacturing process

DOEpatents

Makowiecki, D.M.; Kerns, J.A.; Blaedel, K.L.; Colella, N.J.; Davis, P.J.; Juntz, R.S.

1998-06-09

A reusable grinding tool consisting of a replaceable single layer of abrasive particles intimately bonded to a precisely configured tool substrate, and a process for manufacturing the grinding tool are disclosed. The tool substrate may be ceramic or metal and the abrasive particles are preferably diamond, but may be cubic boron nitride. The manufacturing process involves: coating a configured tool substrate with layers of metals, such as titanium, copper and titanium, by physical vapor deposition (PVD); applying the abrasive particles to the coated surface by a slurry technique; and brazing the abrasive particles to the tool substrate by alloying the metal layers. The precision control of the composition and thickness of the metal layers enables the bonding of a single layer or several layers of micron size abrasive particles to the tool surface. By the incorporation of an easily dissolved metal layer in the composition such allows the removal and replacement of the abrasive particles, thereby providing a process for replenishing a precisely machined grinding tool with fine abrasive particles, thus greatly reducing costs as compared to replacing expensive grinding tools. 11 figs.

Precision replenishable grinding tool and manufacturing process

DOEpatents

Makowiecki, Daniel M.; Kerns, John A.; Blaedel, Kenneth L.; Colella, Nicholas J.; Davis, Pete J.; Juntz, Robert S.

1998-01-01

A reusable grinding tool consisting of a replaceable single layer of abrasive particles intimately bonded to a precisely configured tool substrate, and a process for manufacturing the grinding tool. The tool substrate may be ceramic or metal and the abrasive particles are preferably diamond, but may be cubic boron nitride. The manufacturing process involves: coating a configured tool substrate with layers of metals, such as titanium, copper and titanium, by physical vapor deposition (PVD); applying the abrasive particles to the coated surface by a slurry technique; and brazing the abrasive particles to the tool substrate by alloying the metal layers. The precision control of the composition and thickness of the metal layers enables the bonding of a single layer or several layers of micron size abrasive particles to the tool surface. By the incorporation of an easily dissolved metal layer in the composition such allows the removal and replacement of the abrasive particles, thereby providing a process for replenishing a precisely machined grinding tool with fine abrasive particles, thus greatly reducing costs as compared to replacing expensive grinding tools.

Sauna-Induced Body Mass Loss in Young Sedentary Women and Men

PubMed Central

Podstawski, Robert; Boraczyński, Tomasz; Boraczyński, Michał

2014-01-01

The aim of the study was to evaluate the relationship between body mass index (BMI) and body mass loss (BML) induced by thermal stress in a dry sauna. The study was conducted on a group of 674 sedentary students, 326 women and 348 men aged 19-20. The correlations between BMI scores and BML were determined. The subjects were placed in supine position in a dry sauna for two sessions of 10 minutes each with a 5-minute break. The influence of BMI on the amount of BML in the sauna was determined by nonlinear stepwise regression. The smallest BML was noted in underweight subjects; students with normal weight lost more weight, whereas the greatest BML was reported in overweight and obese subjects. Persons with a high BMI are at higher risk of dehydration, and they should pay particular attention to replenishing fluids during a visit to the sauna. The proposed equations for calculating BML based on a person's BMI can be useful in estimating the amount of fluids that should be replenished by both men and women during a visit to a dry sauna. PMID:25614882

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.

PubMed

Michalski, Nicolas; Goutman, Juan D; Auclair, Sarah Marie; Boutet de Monvel, Jacques; Tertrais, Margot; Emptoz, Alice; Parrin, Alexandre; Nouaille, Sylvie; Guillon, Marc; Sachse, Martin; Ciric, Danica; Bahloul, Amel; Hardelin, Jean-Pierre; Sutton, Roger Bryan; Avan, Paul; Krishnakumar, Shyam S; Rothman, James E; Dulon, Didier; Safieddine, Saaid; Petit, Christine

2017-11-07

Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C 2 -domain, Ca 2+ -binding transmembrane protein of synaptic vesicles. To decipher the role of otoferlin in the synaptic vesicle cycle, we produced knock-in mice ( Otof Ala515,Ala517/Ala515,Ala517 ) with lower Ca 2+ -binding affinity of the C 2 C domain. The IHC ribbon synapse structure, synaptic Ca 2+ currents, and otoferlin distribution were unaffected in these mutant mice, but auditory brainstem response wave-I amplitude was reduced. Lower Ca 2+ sensitivity and delay of the fast and sustained components of synaptic exocytosis were revealed by membrane capacitance measurement upon modulations of intracellular Ca 2+ concentration, by varying Ca 2+ influx through voltage-gated Ca 2+ -channels or Ca 2+ uncaging. Otoferlin thus functions as a Ca 2+ sensor, setting the rates of primed vesicle fusion with the presynaptic plasma membrane and synaptic vesicle pool replenishment in the IHC active zone.

Pleasure: The missing link in the regulation of sleep.

PubMed

Rial, R V; Canellas, F; Gamundí, A; Akaârir, M; Nicolau, M C

2018-05-01

Although largely unrecognized by sleep scholars, sleeping is a pleasure. This report aims first, to fill the gap: sleep, like food, water and sex, is a primary reinforcer. The levels of extracellular mesolimbic dopamine show circadian oscillations and mark the "wanting" for pro-homeostatic stimuli. Further, the dopamine levels decrease during waking and are replenished during sleep, in opposition to sleep propensity. The wanting of sleep, therefore, may explain the homeostatic and circadian regulation of sleep. Accordingly, sleep onset occurs when the displeasure of excessive waking is maximal, coinciding with the minimal levels of mesolimbic dopamine. Reciprocally, sleep ends after having replenished the limbic dopamine levels. Given the direct relation between waking and mesolimbic dopamine, sleep must serve primarily to gain an efficient waking. Pleasant sleep (i.e. emotional sleep), can only exist in animals capable of feeling emotions. Therefore, although sleep-like states have been described in invertebrates and primitive vertebrates, the association sleep-pleasure clearly marks a difference between the sleep of homeothermic vertebrates and cool blooded animals. Copyright © 2018 Elsevier Ltd. All rights reserved.

Self-Replenishable Anti-Waxing Organogel Materials.

PubMed

Yao, Xi; Wu, Shuwang; Chen, Lie; Ju, Jie; Gu, Zhandong; Liu, Mingjie; Wang, Jianjun; Jiang, Lei

2015-07-27

Solid deposition, such as the formation of ice on outdoor facilities, the deposition of scale in water reservoirs, the sedimentation of fat, oil, and grease (FOG) in sewer systems, and the precipitation of wax in petroleum pipelines, cause a serious waste of resources and irreversible environmental pollution. Inspired by fish and pitcher plants, we present a self-replenishable organogel material which shows ultra-low adhesion to solidified paraffin wax and crude oil by absorption of low-molar-mass oil from its crude-oil environment. Adhesion of wax on the organogel surface was over 500 times lower than adhesion to conventional material surfaces and the wax was found to slide off under the force of gravity. This design concept of a gel with decreased adhesion to wax and oil can be extended to deal with other solid deposition problems. © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Diurnal Characteristics of Surface-Level O3 and Other Trace Gases in New England

NASA Astrophysics Data System (ADS)

Talbot, R.; Mao, H.; Sive, B.

2003-12-01

We use data from air quality monitoring sites operated by the Atmospheric Investigation, Regional Modeling, Analysis and Prediction (AIRMAP) program to examine the diurnal characteristics of O3, CO, CO2 and selected volatile organic compounds (VOCs) in the New England atmosphere. Throughout the year a nocturnal inversion forms several hundred meters above the surface on 25% of the days in winter with its frequency of occurrence increasing to 50% in summer. Below the inversion O3 is typically depleted to zero while other gases including CO2, alkanes and alkenes exhibit several-fold enhancements due to local emission sources. The daily time period with O3 < 5 ppbv varies from < 0.5 to 21 hours, with a mean of 3.5 hours. Typically the depletion intervals are shortest in summer and last the longest in winter. The rates of nighttime depletion and daytime replenishment of O3 are very similar, ranging from a few ppbv hr-1 to 25 ppbv hr-1. Due to the rural location of the AIRMAP sites, it appears that the depletion is mainly due to dry deposition with an occasional contribution of titration by NO. The relative enhancements of CO2 and VOCs relative to urban tracers such as C2HCl3 and C2Cl4, which have minimal local sources, provides information on the magnitude and nature of natural and anthropogenic sources.

Effects of mass media campaign exposure intensity and durability on quit attempts in a population-based cohort study

PubMed Central

Wakefield, M. A.; Spittal, M. J.; Yong, H-H.; Durkin, S. J.; Borland, R.

2011-01-01

Objective: To assess the extent to which intensity and timing of televised anti-smoking advertising emphasizing the serious harms of smoking influences quit attempts. Methods: Using advertising gross rating points (GRPs), we estimated exposure to tobacco control and nicotine replacement therapy (NRT) advertising in the 3, 4–6, 7–9 and 10–12 months prior to follow-up of a replenished cohort of 3037 Australian smokers during 2002–08. Using generalized estimating equations, we related the intensity and timing of advertising exposure from each source to the likelihood of making a quit attempt in the 3 months prior to follow-up. Results: Tobacco control advertising in the 3-month period prior to follow-up, but not in more distant past periods, was related to a higher likelihood of making a quit attempt. Each 1000 GRP increase per quarter was associated with an 11% increase in making a quit attempt [odds ratio (OR) = 1.11, 95% confidence interval (CI) 1.03–1.19, P = 0.009)]. NRT advertising was unrelated to quit attempts. Conclusions: Tobacco control advertising emphasizing the serious harms of smoking is associated with short-term increases in the likelihood of smokers making a quit attempt. Repeated cycles of higher intensity tobacco control media campaigns are needed to sustain high levels of quit attempts. PMID:21730252

Resynthesis of muscle glycogen after soccer specific performance examined by 13C-magnetic resonance spectroscopy in elite players.

PubMed

Zehnder, M; Rico-Sanz, J; Kühne, G; Boutellier, U

2001-05-01

The purpose of this study was to examine using 13C-magnetic resonance spectroscopy whether muscle glycogen (Gly) utilized during a simulation of a fatiguing soccer match followed by repeated sprints would be resynthesized during the next 24 h while players consumed their habitual diet. A group of 12 elite young players [mean age 17.5 (SD 0.8) years, mean body mass 68.9 (SD 6.6) kg, mean height 177.0 (SD 5.4) cm] participated in the study. Average muscle Gly content before the simulation was 134 (SD 16) mmol.(kg wet mass)-1 and decreased during the test (P < 0.001) to 80 (SD 29) mmol.(kg wet mass)-1. The value had increased (P < 0.01) to 122 (SD 33) mmol.(kg wet mass)-1 24 h later but it was not significantly different from the value obtained before the soccer test. Dietary analysis of the food intake during the 24 h after the running test revealed that players consumed an average of 2,681 (SD 970) kcal.day-1. Mean daily protein, fat, and carbohydrate (CHO) intakes were 85 (SD 29), 99 (SD 44), and 327 (SD 116) g, respectively. The mean amounts of CHO intake normalised to body mass were 4.8 (SD 1.8) g.(kg body mass)-1. In conclusion, the results of this study showed that despite a CHO intake of less than 5 g.(kg body mass)-1 the habitual diet of soccer players might be sufficient to replenish in 24 h the muscle Gly utilized during soccer specific performance. However, cumulative deficits of about 10% in Gly replenishment as found in the present study might provoke decrements in performance. Thus, players should pay attention to their habitual diets and add more carbohydrates to replenish their daily deficits and perhaps increase their basal levels of intake.

Activity Induces Fmr1-Sensitive Synaptic Capture of Anterograde Circulating Neuropeptide Vesicles

PubMed Central

Cavolo, Samantha L.; Bulgari, Dinara; Deitcher, David L.

2016-01-01

Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out of the nerve terminal. Activity increases DCV capture to rapidly replenish synaptic neuropeptide stores following release. However, it is not known whether this is due to enhanced bidirectional capture. Here experiments at the Drosophila neuromuscular junction, where DCVs contain neuropeptides and a bone morphogenic protein, show that activity-dependent replenishment of synaptic neuropeptides following release is evident after inhibiting the retrograde transport with the dynactin disruptor mycalolide B or photobleaching DCVs entering a synaptic bouton by retrograde transport. In contrast, photobleaching anterograde transport vesicles entering a bouton inhibits neuropeptide replenishment after activity. Furthermore, tracking of individual DCVs moving through boutons shows that activity selectively increases capture of DCVs undergoing anterograde transport. Finally, upregulating fragile X mental retardation 1 protein (Fmr1, also called FMRP) acts independently of futsch/MAP-1B to abolish activity-dependent, but not constitutive, capture. Fmr1 also reduces presynaptic neuropeptide stores without affecting activity-independent delivery and evoked release. Therefore, presynaptic motoneuron neuropeptide storage is increased by a vesicle capture mechanism that is distinguished from constitutive bidirectional capture by activity dependence, anterograde selectivity, and Fmr1 sensitivity. These results show that activity recruits a separate mechanism than used at rest to stimulate additional synaptic capture of DCVs for future release of neuropeptides and neurotrophins. SIGNIFICANCE STATEMENT Synaptic release of neuropeptides and neurotrophins depends on presynaptic accumulation of dense-core vesicles (DCVs). At rest, DCVs are captured bidirectionally as they circulate through Drosophila motoneuron terminals by anterograde and retrograde transport. Here we show that activity stimulates further synaptic capture that is distinguished from basal capture by its selectivity for anterograde DCVs and its inhibition by overexpression of the fragile X retardation protein Fmr1. Fmr1 dramatically lowers DCV numbers in synaptic boutons. Therefore, activity-dependent anterograde capture is a major determinant of presynaptic peptide stores. PMID:27852784

On-Orbit and Ground Performance of the PGBA Plant Growth Facility

NASA Technical Reports Server (NTRS)

Hoehn, A.; Chamberlain, D. J.; Forsyth, S. W.; Hanna, D. S.; Scovazzo, P.; Stodieck, L. S.; Heyenga, G.; Kliss, Mark

1997-01-01

PGBA, a plant growth facility developed for commercial space biotechnology research, successfully grew a total of 30 plants (6 species) for 10 days on board the Space Shuttle Endeavour (STS-77) and is scheduled for reflight on board MSL-1 (STS-83) for a 16 day flight. The PGBA life support systems provide atmospheric, thermal, and humidity control as well as lighting and nutrient supply in a 23.6 liter chamber. Atmosphere treatment includes ethylene and other hydrocarbon removal, CO2 replenishment, and O2 control. The normally closed system uses controlled CO2 replenishment from the crew cabin as required by the plants. Temperature is controlled (1 C) at user-specified setpoints between 20-32 C, using water-filled coolant loops, solid state Peltier thermoelectric devices, and liquid heat exchangers. The thermoelectric cooling systems were optimized for low power consumption and high cooling efficiencies. Relative humidity is maintained between 60-100% using a cooled porous metal plate to remove water vapor from the air stream without cooling the bulk air below the dew point. The lighting system utilizes three compact fluorescent bi-axial lights with variable lighting control and light intensity (PAR) between 220 and 330 micromol/sq m/s at a distance of 20 cm in spaceflight configuration (on orbit power limited to 230 Watt for entire payload). A ground, up to 550 micromol/sq m/s light intensity can be achieved with 330 Watt payload power consumption. Plant water and nutrient support is sustained via the 'Nutrient Pack' system including the passive or active 'Water Replenishable Nutrient Pack.' The root matrix material (soil or Agar) and nutrient formulation of each pack is prepared according to plant species and experimental requirements. These systems were designed by NASA Ames personnel. Data acquisition and control systems provide 32 channels of environmental data as well as digitized or analog video signals for downlink.

Optimal diving behaviour and respiratory gas exchange in birds.

PubMed

Halsey, Lewis G; Butler, Patrick J

2006-11-01

This review discusses the advancements in our understanding of the physiology and behaviour of avian diving that have been underpinned by optimal foraging theory and the testing of optimal models. To maximise their foraging efficiency during foraging periods, diving birds must balance numerous factors that are directly or indirectly related to the replenishment of the oxygen stores and the removal of excess carbon dioxide. These include (1) the time spent underwater (which diminishes the oxygen supply, increases carbon dioxide levels and may even include a build up of lactate due to anaerobic metabolism), (2) the time spent at the surface recovering from the previous dive and preparing for the next (including reloading their oxygen supply, decreasing their carbon dioxide levels and possibly also metabolising lactate) and (3) the trade-off between maximising oxygen reserves for consumption underwater by taking in more air to the respiratory system, and minimising the energy costs of positive buoyancy caused by this air, to maximise the time available underwater to forage. Due to its importance in avian diving, replenishment of the oxygen stores has become integral to models of optimal diving, which predict the time budgeting of animals foraging underwater. While many of these models have been examined qualitatively, such tests of predictive trends appear fallible and only quantifiable support affords strong evidence of their predictive value. This review describes how the quantification of certain optimal diving models, using tufted ducks, indeed demonstrates some predictive success. This suggests that replenishment of the oxygen stores and removal of excess carbon dioxide have significant influences on the duration of the surface period between dives. Nevertheless, present models are too simplistic to be robust predictors of diving behaviour for individual animals and it is proposed that they require refinement through the incorporation of other variables that also influence diving behaviour such as, perhaps, prey density and predator avoidance.

The effect of two different interval-training programmes on physiological and performance indices.

PubMed

Sindiani, Mahmood; Eliakim, Alon; Segev, Daria; Meckel, Yoav

2017-08-01

The aim of the present study was to compare the effect of an increasing-distance, interval-training programme and a decreasing-distance, interval-training programme, matched for total distance, on aerobic and anaerobic physiological indices. Forty physical education students were randomly assigned to either the increasing- or decreasing-distance, interval-training group (ITG and DTG), and completed two similar relevant sets of tests before and after six weeks of training. One training programme consisted of increasing-distance interval-training (100-200-300-400-500 m) and the other decreasing-distance interval training (500-400-300-200-100 m). While both training programmes led to a significant improvement in VO 2 max (ES = 0.83-1.25), the improvement in the DTG was significantly greater than in the ITG (14.5 ± 3.6 vs. 7.8 ± 3.2%, p < .05). In addition, while both training programmes led to a significant improvement in all anaerobic indices (ES = 0.83-1.63), the improvements in peak power (15.7 ± 7.8 vs. 8.9 ± 4.7), mean power (10.6 ± 5.4 vs. 6.8 ± 4.4), and fatigue index (18.2 ± 10.9 vs. 7.0 ± 14.2) were significantly greater in the DTG compared to the ITG (p < .05). The main finding of the present study was that beyond the significant positive effects of both training programmes on aerobic and anaerobic fitness, the DTG showed significant superiority over the ITG in improving aerobic and anaerobic performance capabilities. Coaches and athletes should therefore be aware that, in spite of identical total work, an interval-training programme might induce different physiological impacts if the order of intervals is not identical.

Effect of interval training on cognitive functioning and cerebral oxygenation in obese patients: a pilot study.

PubMed

Drigny, Joffrey; Gremeaux, Vincent; Dupuy, Olivier; Gayda, Mathieu; Bherer, Louis; Juneau, Martin; Nigam, Anil

2014-11-01

To assess the effect of a 4-month high-intensity interval training programme on cognitive functioning, cerebral oxygenation, central haemodynamic and cardiometabolic parameters and aerobic capacity in obese patients. Cognitive functioning, cerebral oxygenation, central haemodynamic, cardiometabolic and exercise para-meters were measured before and after a 4-month high-intensity interval training programme in 6 obese patients (mean age 49 years (standard deviation 8), fat mass percentage 31 ± 7%). Body composition (body mass, total and trunk fat mass, waist circumference) and fasting insulin were improved after the programme (p < 0.05). V. O2 and power output at ventilatory threshold and peak power output were improved after the programme (p < 0.05). Cognitive functioning, including short-term and verbal memory, attention and processing speed, was significantly improved after training (p < 0.05). Cerebral oxygen extraction was also improved after training (p < 0.05). These preliminary results indicate that a 4-month high-intensity interval training programme in obese patients improved both cognitive functioning and cere-bral oxygen extraction, in association with improved exercise capacity and body composition.

Crystal Structures of Apo and Metal-Bound Forms of the UreE Protein from Helicobacter pylori: Role of Multiple Metal Binding Sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, Rong; Munger, Christine; Asinas, Abdalin

2010-10-22

The crystal structure of the urease maturation protein UreE from Helicobacter pylori has been determined in its apo form at 2.1 {angstrom} resolution, bound to Cu{sup 2+} at 2.7 {angstrom} resolution, and bound to Ni{sup 2+} at 3.1 {angstrom} resolution. Apo UreE forms dimers, while the metal-bound enzymes are arranged as tetramers that consist of a dimer of dimers associated around the metal ion through coordination by His102 residues from each subunit of the tetramer. Comparison of independent subunits from different crystal forms indicates changes in the relative arrangement of the N- and C-terminal domains in response to metal binding.more » The improved ability of engineered versions of UreE containing hexahistidine sequences at either the N-terminal or C-terminal end to provide Ni{sup 2+} for the final metal sink (urease) is eliminated in the H102A version. Therefore, the ability of the improved Ni{sup 2+}-binding versions to deliver more nickel is likely an effect of an increased local concentration of metal ions that can rapidly replenish transferred ions bound to His102.« less

Treatment of Anemia in Heart Failure: Potential Risks and Benefits of Intravenous Iron Therapy in Cardiovascular Disease

PubMed Central

Jelani, Qurat-ul-ain; Katz, Stuart D.

2010-01-01

Iron-deficiency anemia is common is patients with heart failure (HF), but the optimum diagnostic tests to detect iron deficiency and the treatment options to replete iron have not been fully characterized. Recent studies in patients with HF indicate that intravenous iron can rapidly replenish iron stores in patients having iron-deficiency anemia, with resultant increased hemoglobin levels and improved functional capacity. Preliminary data from a sub-group analysis also suggests that supplemental intravenous iron therapy can improve functional capacity even in those subjects without anemia. The mechanisms responsible for this observation are not fully characterized, but may be related to beneficial effects of iron supplementation on mitochondrial respiration in skeletal muscle. The long-term safety of using intravenous iron supplementation in HF populations is not known. Iron is a known pro-oxidant factor that can inhibit nitric oxide signaling and irreversibly injury cells. Increased iron stores are associated with vascular endothelial dysfunction and increased risk of coronary heart disease events. Additional clinical trials are needed to more fully characterize the therapeutic potential and safety of intravenous iron in HF patients. PMID:20699672

Hybrid armature projectile

DOEpatents

Hawke, Ronald S.; Asay, James R.; Hall, Clint A.; Konrad, Carl H.; Sauve, Gerald L.; Shahinpoor, Mohsen; Susoeff, Allan R.

1993-01-01

A projectile for a railgun that uses a hybrid armature and provides a seed block around part of the outer surface of the projectile to seed the hybrid plasma brush. In addition, the hybrid armature is continuously vaporized to replenish plasma in a plasma armature to provide a tandem armature and provides a unique ridge and groove to reduce plasama blowby.

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

30 CFR 36.25 - Engine exhaust system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... replenished. When the cooling box is used as a flame arrester, one safety device may be accepted provided it... (see § 36.23(b)(2)). (3) In lieu of a space-place flame arrester, an exhaust-gas cooling box or... cooling box will arrest flame. When used as a flame arrester the cooling box shall be equipped with a...

Building a Zoological Teaching Collection of Invertebrates Using Alcoholic Gel

ERIC Educational Resources Information Center

Mugnai, Riccardo; Barbosa, Julio Vianna; Baptista, Darcilio Fernandes

2012-01-01

Teaching collections are of great importance for science instruction at any level. There are several problems linked to the handling and curatorial management of this kind of collection. Among these is the relatively short life-span of specimens, due to the damage from continuous handling by students. Often the specimens used to replenish the…

37 CFR 2.207 - Methods of payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process the charge... fees to a credit card. If credit card information is provided on a form or document other than a form...

Through a Social Space Lens--Interpreting Migration of the Tertiary Educated

ERIC Educational Resources Information Center

Haley, Aimee

2016-01-01

Higher education institutions are thought to rejuvenate and replenish local labour markets with recent graduates, especially in rural locales. While some graduates stay in the area of their alma mater, others return home or to other areas. The aim of this paper is to contribute a synopsis of research results from current peer-reviewed literature…

A Drop through Time

ERIC Educational Resources Information Center

Vowell, Julie; Phillips, Marianne

2007-01-01

Did you know that the water you use today is the same water that was used millions of years ago? How is this possible? Water is continuously replenished through a naturally occurring process known as the water cycle. To help students learn about this important concept, an eight-day unit was created for fifth-grade students to explore the water…

Heat Mining or Replenishable Geothermal Energy? A Project for Advanced-Level Physics Students

ERIC Educational Resources Information Center

Dugdale, Pam

2014-01-01

There is growing interest in the use of low enthalpy geothermal (LEG) energy schemes, whereby heated water is extracted from sandstone aquifers for civic heating projects. While prevalent in countries with volcanic activity, a recently proposed scheme for Manchester offered the perfect opportunity to engage students in the viability of this form…

Regulatory roles of biogenic amines and juvenile hormone in the reproductive behavior of the western tarnished plant bug (Lygus hesperus)

USDA-ARS?s Scientific Manuscript database

Mating induces behavioral and physiological changes in the plant bug Lygus hesperus Knight (Hemiptera: Miridae). Males enter a post-mating refractory period, lasting 24 hrs, during which they replenish the contents of their accessory glands and seminal vesicles. Females experience a similar loss of ...

37 CFR 2.207 - Methods of payment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process the charge... fees to a credit card. If credit card information is provided on a form or document other than a form...

37 CFR 2.207 - Methods of payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process the charge... fees to a credit card. If credit card information is provided on a form or document other than a form...

37 CFR 2.207 - Methods of payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify the amount to be charged to the credit card and such other information as is necessary to process the charge... fees to a credit card. If credit card information is provided on a form or document other than a form...

Maintaining adequate nutrient supply - Principles, decision-support tools, and best management practices [Chapter 6

Treesearch

Robert B. Harrison; Douglas A. Maguire; Deborah Page-Dumroese

2011-01-01

Maintaining adequate nutrient supply to maintain or enhance tree vigor and forest growth requires conservation of topsoil and soil organic matter. Sometimes nutrient amendments are also required to supplement inherent nutrient-pool limitations or replenish nutrients removed in harvested material. The goal is to maintain the productive potential of the soil and, when...

SEALIFT

DTIC Science & Technology

2012-03-01

Dolores Chouest served primarily as a platform for U.S. and Canadian divers to conduct diving operations. MSC Maritime Prepositioning Force ship...Kanawha also performed an underway replenishment following a short-fused request by Canadian navy frigate HMCS Vancouver, allowing Vancouver to bypass...planning careers within the maritime industry . Fourteen MSCPAC and Ship Sup- port Unit San Diego employees served as MSC representatives at the

Advanced supplier partnership practices: a case study.

PubMed

Williams, B R

2000-05-01

This article describes how a supplier partnership was set up to avoid the typical purchasing relationship--price being inversely proportional to quantity and having the purchaser take all the risk of product obsolescence. The case study also describes how rate-based replenishment replaced time-based delivery, and how all these advantages were achieved at reduced administrative costs.

Bioregenerative Life-Support System For Long Missions

NASA Technical Reports Server (NTRS)

Cullingford, Hatice S.

1994-01-01

Collection of four reports proposes integrated bioregenerative life-support system that sustains tens of people isolated from Earth's oxygen and sunlight. System self-sufficient for year or more; continues beyond that period with replenishment of supplies. Used in long-term spaceflights, space stations, such planet bases as those on Earth's Moon or Mars, and submarine vehicles and installations.

Hybrid armature projectile

DOEpatents

Hawke, R.S.; Asay, J.R.; Hall, C.A.; Konrad, C.H.; Sauve, G.L.; Shahinpoor, M.; Susoeff, A.R.

1993-03-02

A projectile for a railgun that uses a hybrid armature and provides a seed block around part of the outer surface of the projectile to seed the hybrid plasma brush. In addition, the hybrid armature is continuously vaporized to replenish plasma in a plasma armature to provide a tandem armature and provides a unique ridge and groove to reduce plasma blowby.

Geology and ground-water hydrology of the Mokelumne area, California

USGS Publications Warehouse

Piper, A.M.; Gale, H.S.; Thomas, H.E.; Robinson, T.W.

1939-01-01

29), and there have been as many as 2,500 wells equipped with irrigation pumping plants (1931). Commonly the wells are pumped only in daylight and are idle over week-ends and holidays, also during and after protracted rainstorms in the early part of the season. In a small district near Victor pumping in recent years has begun in January or February, has reached its height in March, and largely has passed by April. In outlying districts general pumping has begun as late as May, reached its height in June or July, and waned by September. Since 1907 the water table appears to have declined steadily in most of the Mokelumne area except along the river. The decline was least in the Woodbridge Irrigation District, where in four typical wells. the average decline from 1907 to 1937 was 3 feet, or 0.15 foot a year. Among 18 shallow wells in the district of most intensive pumping the average recession of the water table from 1907 to 1927 was 11 feet, or 0.55 foot a year; the greatest measured recession was 15 feet, or 0.75 foot a year. From 1927 to 1933 the water table declined 5 feet or more over most of the central pumping district except within 2 miles of the Mokelumne River, and the greatest measured decline was 9 feet. The area of material recession ,extends 4 to 7 miles eastward beyond the central pumping district, whence it is inferred that pumping has drawn gradually on remote ground-water storage. It is inferred that the Mokelumne River ordinarily has been a losing stream between the Mehrten dam site, near Clements, and the Woodbridge Dam, the area that received the percolate having been triangular with its upstream and having included about 5,200 acres of the flood plain and 36,500 acres in outlying districts to the north and to the south. Mean fluctuations of the water table within the area receiving percolate from ihe river are believed to indicate that relatively little water is drawn from outside the area. Accordingly, simple storage methods are competent for a ground-water inventory. It is inferred that the rate of seepage loss from the river depends jointly upon river discharge, stage in the Woodbridge Reservoir, and groundwater pumpage. The foregoing inferences lead to the following conclusions with respect to ground-water replenishment by seepage loss from the river in the intensively cultivated district about Lodi: (1) The annual replenishment has tended to increase for at least two decades, owing to the gradual increase in head between surface water and ground water as ground-water levels have been lowered progressively by pumping; (2) annual replenishment has tended to increase, especially in recent years, owing to gradually prolonged use of the Woodbridge Reservoir, for thereby a relatively large wetted area and great differential head have been maintained for an increasing term; (3) the rate of replenishment tends to be greater under regulation than under the so-called natural regimen, to the extent that regulation has maintained a moderately large wetted area and stage in the river through the later part ·of each pumping season, whi1e the ground-water levels have been lowest. Moreover, for any particular yearly run-off below the Mehrten dam site, the replenishment by seepage would tend to be greater under the regulated regimen to the extent that fluctuations in discharge were suppressed, for the greatest yearly mean stage and mean wetted area would be afforded by constant discharge. -Thus, diverting water out of the Mokelumne River Basin at the Pardee Dam does not necessari1y-entail a diminution in ground-water replenishment by seepage loss along the lower reach of the stream, at least in the replenishment beneath the Victor plain above the gaging station at Woodbridge. Rather. the Pardee Dam affords a means for so regulating the discharge as to effect a maximum ground-water replenishment with-a given run-off in the natural channel. Bodies of ground water perched above the regional water table are common in the Laguna formation, especially in its lower part. Conspicuous bodies occur about 3 miles south of Clay, in a district between 1 mile and 5 miles south of Clements, and along Dry Creek in T. 5 N., Rs. 7 and 8 E. From the relation between the water table and the piezometric surface for water confined in deep aquifers, the area receiving percolate from the Mokelumne River may be divided roughly into (1) a central area, extending not :p1ore than half a mi1e beyond the flood plain, in which the piezometric surface is inferred to have stood below the water table throughout the term of the investigation and hence in which the difference in head has favored the percolation of water from shallow beds into deep beds in all seasons, and (2) an outlying area in which the difference in head likewise favors downward percolation into deep beds during the pumping season but favors upward percolation during the nonpumping season. This outlying area includes about 75 percent of the segment of the Victor plain that receives percolate from the river. From 1927 to 1933 the subartesian head that existed during the nonpumping season in the area remote from the river tended to increase; it is therefore inferred that the relative opportunity for seasonal recharge of the shallow water-bearing beds by underfeeding has likewise tended to increase. On the other hand, the negative differential head in wells near the river also has tended to increase; thus in this central area the opportunity for discharge of water from shallow beds by downward percolation has probably tended to increase. It is believed that ground-water storage within the area near the river is not decreased materially by" discharge westward through deep pervious beds, also that the yearly addition to ground-water storage in the outlying area by deep percolation from a remote easterly source is scant and for all practical purposes is offset by downward percolation along the river.

Exercise training in adults with repaired tetralogy of Fallot: A randomized controlled pilot study of continuous versus interval training.

PubMed

Novaković, Marko; Prokšelj, Katja; Rajkovič, Uroš; Vižintin Cuderman, Tjaša; Janša Trontelj, Katja; Fras, Zlatko; Jug, Borut

2018-03-15

Adults with repaired tetralogy of Fallot (ToF) have impaired exercise capacity, vascular and cardiac autonomic function, and quality of life (QoL). Specific effects of high-intensity interval or moderate continuous exercise training on these parameters in adults with repaired ToF remain unknown. Thirty adults with repaired ToF were randomized to either high-intensity interval, moderate intensity continuous training (36 sessions, 2-3 times a week) or usual care (no supervised exercise). Exercise capacity, flow-mediated vasodilation, pulse wave velocity, NT-proBNP and fibrinogen levels, heart rate variability and recovery, and QoL (SF-36 questionnaire) were determined at baseline and after the intervention period. Twenty-seven patients (mean age 39±9years, 63% females, 9 from each group) completed this pilot study. Both training groups improved in at least some parameters of cardiovascular health compared to no exercise. Interval-but not continuous-training improved VO2peak (21.2 to 22.9ml/kg/min, p=0.004), flow-mediated vasodilation (8.4 to 12.9%, p=0.019), pulse wave velocity (5.4 to 4.8m/s, p=0.028), NT-proBNP (202 to 190ng/L, p=0.032) and fibrinogen levels (2.67 to 2.46g/L, p=0.018). Conversely, continuous-but not interval-training improved heart rate variability (low-frequency domain, 0.32 to 0.22, p=0.039), heart rate recovery after 2min post-exercise (40 to 47 beats, p=0.023) and mental domain of SF-36 (87 to 95, p=0.028). Both interval and continuous exercise training modalities were safe. Interval training seems more efficacious in improving exercise capacity, vascular function, NT-proBNP and fibrinogen levels, while continuous training seems more efficacious in improving cardiac autonomic function and QoL. (Clinicaltrials.gov, NCT02643810). Copyright © 2018 Elsevier Ireland Ltd. All rights reserved.

Large Area Silicon Sheet by EFG. [quality control and productivity of edge-defined film-fed growth of ribbons

NASA Technical Reports Server (NTRS)

1979-01-01

Influences on ribbon quality which might be caused by various materials of construction which are used in the growth furnace were assessed. At the present level of ribbon quality, which has produced 8.5% to 9.5% efficient solar cells, no particular influence of any furnace part was detected. The experiments led to the suspicion that the general environment and the somewhat unoptimized materials handling procedures might be responsible for the current variations in ribbon quality and that, therefore, continuous work with this furnace under rather more stringent environmental conditions and operating procedures could perhaps improve materials quality to some extent. The work on the multiple furnace was continued with two multiple growth runs being performed. In these runs, the melt replenishment system performed poorly and extensive modifications to it were designed to make reliable melt feeding for five ribbon growth possible. Additional characterization techniques for wide ribbons, stress measurements, and growth dynamics experiments are reported.

Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects.

PubMed

Knott, Anja; Achterberg, Volker; Smuda, Christoph; Mielke, Heiko; Sperling, Gabi; Dunckelmann, Katja; Vogelsang, Alexandra; Krüger, Andrea; Schwengler, Helge; Behtash, Mojgan; Kristof, Sonja; Diekmann, Heike; Eisenberg, Tanya; Berroth, Andreas; Hildebrand, Janosch; Siegner, Ralf; Winnefeld, Marc; Teuber, Frank; Fey, Sven; Möbius, Janne; Retzer, Dana; Burkhardt, Thorsten; Lüttke, Juliane; Blatt, Thomas

2015-01-01

Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity. © 2015 International Union of Biochemistry and Molecular Biology.

Design Study Conducted of a Stirred and Perfused Specimen Chamber for Culturing Suspended Cells on the International Space Station

NASA Technical Reports Server (NTRS)

Nelson, Emily S.; Kizito, John P.

2003-01-01

A tightly knit numerical/experimental collaboration among the NASA Ames Research Center, NASA Glenn Research Center, and Payload Systems, Inc., was formed to analyze cell culturing systems for the International Space Station. The Cell Culture Unit is a facility scheduled for deployment on the space station by the Cell Culture Unit team at Ames. The facility houses multiple cell specimen chambers (CSCs), all of which have inlets and outlets to allow for replenishment of nutrients and for waste removal. For improved uniformity of nutrient and waste concentrations, each chamber has a pair of counterrotating stir bars as well. Although the CSC can be used to grow a wide variety of organic cells, the current study uses yeast as a model cell. Previous work identified groundbased protocols for perfusion and stirring to achieve yeast growth within the CSC that is comparable to that for yeast cultures grown in a shaken Ehrlenmeyer flask.

A patient with CKD and poor nutritional status.

PubMed

Ikizler, T Alp

2013-12-01

Protein energy wasting is common in patients with CKD and ESRD and is associated with adverse clinical outcomes, such as increased rates of hospitalization and death, in these patients. A multitude of factors can affect the nutritional and metabolic status of patients with CKD, including decreased dietary nutrient intake, catabolic effects of renal replacement therapy, systemic inflammation, metabolic and hormonal derangements, and comorbid conditions (such as diabetes and depression). Unique aspects of CKD also confound reliable assessment of nutritional status, further complicating management of this comorbid condition. In patients in whom preventive measures and oral dietary intake from regular meals cannot help them maintain adequate nutritional status, nutritional supplementation, administered orally, enterally, or parenterally, is effective in replenishing protein and energy stores. The advantages of oral nutritional supplements include proven efficacy, safety, and compliance. Anabolic steroids and exercise, with nutritional supplementation or alone, improve protein stores and represent potential additional approaches for the treatment of PEW. There are several emerging novel therapies, such as appetite stimulants, anti-inflammatory interventions, and anabolic agents.

Nitrogen modulation of legume root architecture signaling pathways involves phytohormones and small regulatory molecules.

PubMed

Mohd-Radzman, Nadiatul A; Djordjevic, Michael A; Imin, Nijat

2013-10-01

Nitrogen, particularly nitrate is an important yield determinant for crops. However, current agricultural practice with excessive fertilizer usage has detrimental effects on the environment. Therefore, legumes have been suggested as a sustainable alternative for replenishing soil nitrogen. Legumes can uniquely form nitrogen-fixing nodules through symbiotic interaction with specialized soil bacteria. Legumes possess a highly plastic root system which modulates its architecture according to the nitrogen availability in the soil. Understanding how legumes regulate root development in response to nitrogen availability is an important step to improving root architecture. The nitrogen-mediated root development pathway starts with sensing soil nitrogen level followed by subsequent signal transduction pathways involving phytohormones, microRNAs and regulatory peptides that collectively modulate the growth and shape of the root system. This review focuses on the current understanding of nitrogen-mediated legume root architecture including local and systemic regulations by different N-sources and the modulations by phytohormones and small regulatory molecules.

Consensus Document of the Spanish Society of Cardiology and the Spanish Society of Internal Medicine on the diagnosis and treatment of iron deficiency in heart failure.

PubMed

Manito, N; Cerqueiro, J M; Comín-Colet, J; García-Pinilla, J M; González-Franco, A; Grau-Amorós, J; Peraira, J R; Manzano, L

Iron deficiency in patients with heart failure is a medical problem of recent particular interest. This interest has resulted from the publication of several clinical trials that demonstrated that the administration of intravenous iron to such patients improved their functional capacity and even reduced the number of hospitalisations for heart failure decompensation. However, applying the evidence from these studies in clinical practice is still controversial, both in terms of the diagnostic criteria for iron deficiency (absolute and functional) and the optimal method for iron replenishment. This article is a consensus document that integrates the recommendations of the Spanish Society of Internal Medicine and the Spanish Society of Cardiology. The article reviews the scientific evidence and proposes a diagnostic and therapeutic performance protocol for iron deficiency in heart failure. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

Role of probiotics in urogenital healthcare

PubMed Central

Waigankar, Santosh S.; Patel, Vimal

2011-01-01

Urogenital infections are one of the most common causes for a woman to visit a gynecologist or a urologist. The well-known association between abnormal vaginal microbial flora and its formidable risk in the increased incidence of urinary tract infection underscores the importance of understanding the microbial flora and the efforts needed to maintain it, for ensuring urogenital health. Surprisingly in spite of the increased incidence urogenital infections receive very less attention from the medical fraternity. Growing awareness among people and newer advances in the medical field has brought them into the limelight. The importance of replenishing these depleting commensals with ‘probiotics’ has resurfaced in a big way. As the days go by science and medicines will touch new milestones, which will include probiotics. The value of a probiotics cannot be taken at face value. Probiotics must not be considered a panacea for treating urogenital infections. However, the available data promises that it will be a strong option in improving and maintaining urogenital health. PMID:21897732

A Novel Membrane-Based Anti-Diabetic Action of Atorvastatin

PubMed Central

Horvath, Emily M.; Tackett, Lixuan; Elmendorf, Jeffrey S.

2008-01-01

We recently found that chromium picolinate (CrPic), a nutritional supplement thought to improve insulin sensitivity in individuals with impaired glucose tolerance, enhances insulin action by lowering plasma membrane (PM) cholesterol. Recent in vivo studies suggest that cholesterol-lowering statin drugs benefit insulin sensitivity in insulin-resistant patients, yet a mechanism is unknown. We report here that atorvastatin (ATV) diminished PM cholesterol by 22% (P<0.05) in 3T3-L1 adipocytes. As documented for CrPic, this small reduction in PM cholesterol enhanced insulin action. Replenishment of cholesterol mitigated the positive effects of ATV on insulin sensitivity. Co-treatment with CrPic and ATV did not amplify the extent of PM cholesterol loss or insulin sensitivity gain. In addition, analyses of insulin signal transduction suggest a non-signaling basis of both therapies. Our data reveal an unappreciated beneficial non-hepatic effect of statin action and highlight a novel mechanistic similarity between two recently recognized therapies of impaired glucose tolerance. PMID:18514061

Tear exchange and contact lenses: a review.

PubMed

Muntz, Alex; Subbaraman, Lakshman N; Sorbara, Luigina; Jones, Lyndon

2015-01-01

Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design innovations have been proposed, but no substantial improvement in soft lens tear exchange has been reported. Researchers have determined post-lens tear exchange using several methods, notably fluorophotometry. However, due to technological limitations, little remains known about tear hydrodynamics around the lens and, to-date, true tear exchange with contact lenses has not been shown. Further knowledge regarding tear exchange could be vital in aiding better contact lens design, with the prospect of alleviating certain adverse ocular responses. This article reviews the literature to-date on the significance, implications and measurement of tear exchange with contact lenses. Copyright © 2014 Spanish General Council of Optometry. Published by Elsevier Espana. All rights reserved.

Analysis of shallow-groundwater dynamic responses to water supply change in the Haihe River plain

NASA Astrophysics Data System (ADS)

Lin, Z.; Lin, W.; Pengfei, L.

2015-05-01

When the middle route of the South-to-North Water Diversion Project is completed, the water supply pattern of the Haihe River plain in North China will change significantly due to the replenishment of water sources and groundwater-exploitation control. The water-cycle-simulation model - MODCYCLE, has been used in simulating the groundwater dynamic balance for 2001-2010. Then different schemes of water supply in 2020 and 2030 were set up to quantitatively simulate the shallow-groundwater dynamic responses in the future. The results show that the total shallow-groundwater recharge is mainly raised by the increases in precipitation infiltration and surface-water irrigation infiltration. Meanwhile, the decrease of groundwater withdrawal contributes to reduce the total discharge. The recharge-discharge structure of local groundwater was still in a negative balance but improved gradually. The shallow-groundwater level in most parts was still falling before 2030, but more slowly. This study can benefit the rational exploitation of water resources in the Haihe River plain.

LQ optimal and reaching law-based sliding modes for inventory management systems

NASA Astrophysics Data System (ADS)

Ignaciuk, Przemysław; Bartoszewicz, Andrzej

2012-01-01

In this article, the theory of discrete sliding-mode control is used to design new supply strategies for periodic-review inventory systems. In the considered systems, the stock used to fulfil an unknown, time-varying demand can be replenished from a single supply source or from multiple suppliers procuring orders with different delays. The proposed strategies guarantee that demand is always entirely satisfied from the on-hand stock (yielding the maximum service level), and the warehouse capacity is not exceeded (which eliminates the cost of emergency storage). In contrast to the classical, stochastic approaches, in this article, we focus on optimising the inventory system dynamics. The parameters of the first control strategy are selected by minimising a quadratic cost functional. Next, it is shown how the system dynamical performance can be improved by applying the concept of a reaching law with the appropriately adjusted reaching phase. The stable, nonoscillatory behaviour of the closed-loop system is demonstrated and the properties of the designed controllers are discussed and strictly proved.

Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes.

PubMed

Francois, Monique E; Durrer, Cody; Pistawka, Kevin J; Halperin, Frank A; Little, Jonathan P

2016-11-01

Different modes of exercise, disease, and training status can modify endothelial shear stress and result in distinct effects on endothelial function. To date, no study has examined the influence of type 2 diabetes (T2D) and training status on the acute endothelial response to different modes of interval exercise (INT). We examined the effect of a single session of resistance- and cardio-based INT compared with a time-matched control on endothelial function in 12 age-matched T2D participants, 12 untrained, and 11 trained adults (aged 56 ± 7 yr). Flow-mediated dilation (%FMD) of the brachial artery was assessed at baseline and immediately, 1, and 2 h after an acute bout of cardio interval (C-INT), resistance interval (R-INT), and seated control (CTL); these interventions were randomized and separated by >2 days. C-INT involved seven 1-min cycling intervals at 85% of peak power with 1-min recovery between. R-INT involved the same pattern of seven 1-min intervals using leg resistance exercises. Endothelial function (%FMD) was improved after R-INT in all groups (Condition × Time interaction, P < 0.01), an effect that was most robust in T2D where %FMD was higher immediately (+4.0 ± 2.8%), 1 h (+2.5 ± 2.5%), and 2 h (+1.9 ± 1.9%) after R-INT compared with CTL (P < 0.01 for all). C-INT improved %FMD in T2D at 1-h postexercise (+1.6 ± 2.2%, P = 0.03) compared with CTL. In conclusion, R-INT acutely improves endothelial function throughout the 2-h postexercise period in T2D patients. The long-term impact of resistance exercise performed in an interval pattern is warranted. Copyright © 2016 the American Physiological Society.

Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes

PubMed Central

Francois, Monique E.; Durrer, Cody; Pistawka, Kevin J.; Halperin, Frank A.

2016-01-01

Different modes of exercise, disease, and training status can modify endothelial shear stress and result in distinct effects on endothelial function. To date, no study has examined the influence of type 2 diabetes (T2D) and training status on the acute endothelial response to different modes of interval exercise (INT). We examined the effect of a single session of resistance- and cardio-based INT compared with a time-matched control on endothelial function in 12 age-matched T2D participants, 12 untrained, and 11 trained adults (aged 56 ± 7 yr). Flow-mediated dilation (%FMD) of the brachial artery was assessed at baseline and immediately, 1, and 2 h after an acute bout of cardio interval (C-INT), resistance interval (R-INT), and seated control (CTL); these interventions were randomized and separated by >2 days. C-INT involved seven 1-min cycling intervals at 85% of peak power with 1-min recovery between. R-INT involved the same pattern of seven 1-min intervals using leg resistance exercises. Endothelial function (%FMD) was improved after R-INT in all groups (Condition × Time interaction, P < 0.01), an effect that was most robust in T2D where %FMD was higher immediately (+4.0 ± 2.8%), 1 h (+2.5 ± 2.5%), and 2 h (+1.9 ± 1.9%) after R-INT compared with CTL (P < 0.01 for all). C-INT improved %FMD in T2D at 1-h postexercise (+1.6 ± 2.2%, P = 0.03) compared with CTL. In conclusion, R-INT acutely improves endothelial function throughout the 2-h postexercise period in T2D patients. The long-term impact of resistance exercise performed in an interval pattern is warranted. PMID:27638878

Loglines. July - August 2012

DTIC Science & Technology

2012-08-01

ammunition ship USNS Sacagawea (left) and the amphibious transport dock ship USS Mesa Verde conduct an underway replenishment in the Mediterranean Sea...Odyssey Dawn and Unified Protector in Libya, for example, the organization went from supporting one ship in the Mediterranean Sea to 28. “They all...a combination of nutritional food groups including vegetables, beverages, meat, poultry, desserts and condiments, which provide a balanced diet

The Future of Additive Manufacturing in Air Force Acquisition

DTIC Science & Technology

2017-03-22

manufacturing data - Designing and deploying a virtual aircraft fleet for future conflict - Space-based satellite production for defense capabilities via...changing system design via lower production costs, enhanced performance possibilities, and rapid replenishment. In the Technology Maturation and Risk... manufacturing as well as major cost savings via reduction of required materials, unique tooling, specialized production plans, and segments of the

Blowing in the Wind: A Review of Wind Power Technology

ERIC Educational Resources Information Center

Harris, Frank

2014-01-01

The use of wind as a replenishable energy resource has come back into favour in recent decades. It is much promoted as a viable, clean energy option that will help towards reducing CO[subscript 2] emissions in the UK. This article examines the history of wind power and considers the development of wind turbines, together with their economic,…

An EOQ Model with Two-Parameter Weibull Distribution Deterioration and Price-Dependent Demand

ERIC Educational Resources Information Center

Mukhopadhyay, Sushanta; Mukherjee, R. N.; Chaudhuri, K. S.

2005-01-01

An inventory replenishment policy is developed for a deteriorating item and price-dependent demand. The rate of deterioration is taken to be time-proportional and the time to deterioration is assumed to follow a two-parameter Weibull distribution. A power law form of the price dependence of demand is considered. The model is solved analytically…

76 FR 40410 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... the investment bank syndicate the night before the first day of trading, to determine the LRP value... During the First Day of Trading of an Initial Public Offering on the Exchange July 1, 2011. Pursuant to... for a different liquidity replenishment point (``LRP'') value range during the first day of trading of...

76 FR 40413 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... the investment bank syndicate the night before the first day of trading, to determine the LRP value... Point Value Range During the First Day of Trading of an Initial Public Offering on the Exchange July 1... for a different liquidity replenishment point (``LRP'') value range during the first day of trading of...

Forest water contamination

Treesearch

Roger M. Rowell

2006-01-01

Forests play a key role in cleaning water. Precipitation is “'filtered” through the tree canopy and filtered again throuph the organic matter on the forest floor. The water then seeps into the subsurface to replenish the ground water. Approximately 80% of the freshwater in the United States originates in the 650 million acres (265 million hectares) of forest that...

A Simulation of Alternatives for Wholesale Inventory Replenishment

DTIC Science & Technology

2016-03-01

algorithmic details. The last method is a mixed-integer, linear optimization model. Comparative Inventory Simulation, a discrete event simulation model, is...simulation; event graphs; reorder point; fill-rate; backorder; discrete event simulation; wholesale inventory optimization model 15. NUMBER OF PAGES...model. Comparative Inventory Simulation, a discrete event simulation model, is designed to find fill rates achieved for each National Item

Examination of the Benefits of Standardized Interfaces on Space Systems

DTIC Science & Technology

2015-09-01

them to enter the once impenetrable aerospace market: Elon Musk with Space Exploration Technologies (SpaceX), Richard Branson with Virgin Galactic, and...systems-engineering- guide/se-life cycle-building-blocks/concept-development/highlevel-conceptual- definition. Musk , Elon . 2009. Risky Business... Musk , 2009) Unknown effects of prolonged exposure to radiation Degraded system capability (JPL 2015) Replenishment of the system capability may

Do birds select habitat or food resources? Nearctic-neotropic migrants in northeastern Costa Rica

Treesearch

Jared D. Wolfe; Matthew D. Johnson; C. John Ralph; R. Mark Brigham

2014-01-01

Nearctic-neotropic migrant birds need to replenish energy reserves during stopover periods to successfully complete their semiannual movements. In this study we used linear models to examine the habitat use of 11 migrant species in northeastern Costa Rica to better understand the influence of food and structural resources on the presence of birds during stopover...

76 FR 14699 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Amendment No. 3...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-17

... rule change.\\10\\ The Commission is publishing this notice and order to solicit comments on Amendment No... securities. Under this proposal, Nasdaq would suspend trading in a security if a trade in that security is... Volatility Guard is similar in purpose to the Liquidity Replenishment Points (``LRPs'') rules that currently...

For Want of a Nail: An Assessment of Global Positioning System Satellite Replenishment

DTIC Science & Technology

2004-05-26

The growing reliance on GPS has some concerned about the ability of the aviation industry to safely operate in case of a GPS failure. Langhorne ...connection will further reduce 145 Simon P . Worden and John E. Shaw, Whither Space Power? Forging...precision effects. 158 Fred P . Stein, "Observations on the Emergence of Network Centric Warfare

Sunrayce 97 Continues Day 4 - Fulton to Lee's Summit

Science.gov Websites

(202) 586-0713 Lee's Summit, MO -- Massachusetts Institute of Technology (MIT) took Day IV and maintained the overall lead as sunrayce 97 completed its fourth day. The elapsed time for the day for the attaining good sun early enough in the day to replenish the batteries, as such a fast pace will deplete them

From Apprentice to Journeyman to Partner: Benjamin Franklin's Workers and the Growth of the Early-American Printing Trade.

ERIC Educational Resources Information Center

Frasca, Ralph

In studying the history of the American press, little attention has been given to printing networks and the apprenticeship system, factors which permitted the press not only to survive but to grow. Essential to press growth was the apprenticeship system, vocational education which replenished and augmented the craft's practitioners. Apprentices…

Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism.

PubMed

Ikizler, T Alp; Cano, Noel J; Franch, Harold; Fouque, Denis; Himmelfarb, Jonathan; Kalantar-Zadeh, Kamyar; Kuhlmann, Martin K; Stenvinkel, Peter; TerWee, Pieter; Teta, Daniel; Wang, Angela Yee-Moon; Wanner, Christoph

2013-12-01

Protein energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes, especially in individuals receiving maintenance dialysis therapy. A multitude of factors can affect the nutritional and metabolic status of CKD patients requiring a combination of therapeutic maneuvers to prevent or reverse protein and energy depletion. These include optimizing dietary nutrient intake, appropriate treatment of metabolic disturbances such as metabolic acidosis, systemic inflammation, and hormonal deficiencies, and prescribing optimized dialytic regimens. In patients where oral dietary intake from regular meals cannot maintain adequate nutritional status, nutritional supplementation, administered orally, enterally, or parenterally, is shown to be effective in replenishing protein and energy stores. In clinical practice, the advantages of oral nutritional supplements include proven efficacy, safety, and compliance. Anabolic strategies such as anabolic steroids, growth hormone, and exercise, in combination with nutritional supplementation or alone, have been shown to improve protein stores and represent potential additional approaches for the treatment of PEW. Appetite stimulants, anti-inflammatory interventions, and newer anabolic agents are emerging as novel therapies. While numerous epidemiological data suggest that an improvement in biomarkers of nutritional status is associated with improved survival, there are no large randomized clinical trials that have tested the effectiveness of nutritional interventions on mortality and morbidity.

Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.

PubMed

Xu, Xihui; Pang, Jiaojiao; Chen, Yuguo; Bucala, Richard; Zhang, Yingmei; Ren, Jun

2016-03-04

Aging leads to unfavorable geometric and functional sequelae in the heart. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) plays a role in the maintenance of cardiac homeostasis under stress conditions although its impact in cardiac aging remains elusive. This study was designed to evaluate the role of MIF in aging-induced cardiac anomalies and the underlying mechanism involved. Cardiac geometry, contractile and intracellular Ca(2+) properties were examined in young (3-4 mo) or old (24 mo) wild type and MIF knockout (MIF(-/-)) mice. Our data revealed that MIF knockout exacerbated aging-induced unfavorable structural and functional changes in the heart. The detrimental effect of MIF knockout was associated with accentuated loss in cardiac autophagy with aging. Aging promoted cardiac inflammation, the effect was attenuated by MIF knockout. Intriguingly, aging-induced unfavorable responses were reversed by treatment with the autophagy inducer rapamycin, with improved myocardial ATP availability in aged WT and MIF(-/-) mice. Using an in vitro model of senescence, MIF knockdown exacerbated doxorubicin-induced premature senescence in H9C2 myoblasts, the effect was ablated by MIF replenishment. Our data indicated that MIF knockout exacerbates aging-induced cardiac remodeling and functional anomalies despite improved inflammation, probably through attenuating loss of autophagy and ATP availability in the heart.

Improving Assessment of Work Related Mental Health Function Using the Work Disability Functional Assessment Battery (WD-FAB).

PubMed

Marfeo, Elizabeth E; Ni, Pengsheng; McDonough, Christine; Peterik, Kara; Marino, Molly; Meterko, Mark; Rasch, Elizabeth K; Chan, Leighton; Brandt, Diane; Jette, Alan M

2018-03-01

Purpose To improve the mental health component of the Work Disability Functional Assessment Battery (WD-FAB), developed for the US Social Security Administration's (SSA) disability determination process. Specifically our goal was to expand the WD-FAB scales of mood & emotions, resilience, social interactions, and behavioral control to improve the depth and breadth of the current scales and expand the content coverage to include aspects of cognition & communication function. Methods Data were collected from a random, stratified sample of 1695 claimants applying for the SSA work disability benefits, and a general population sample of 2025 working age adults. 169 new items were developed to replenish the WD-FAB scales and analyzed using factor analysis and item response theory (IRT) analysis to construct unidimensional scales. We conducted computer adaptive test (CAT) simulations to examine the psychometric properties of the WD-FAB. Results Analyses supported the inclusion of four mental health subdomains: Cognition & Communication (68 items), Self-Regulation (34 items), Resilience & Sociability (29 items) and Mood & Emotions (34 items). All scales yielded acceptable psychometric properties. Conclusions IRT methods were effective in expanding the WD-FAB to assess mental health function. The WD-FAB has the potential to enhance work disability assessment both within the context of the SSA disability programs as well as other clinical and vocational rehabilitation settings.

Contribution of extracellular glutamine as an anaplerotic substrate to neuronal metabolism: a re-evaluation by multinuclear NMR spectroscopy in primary cultured neurons.

PubMed

Shokati, Touraj; Zwingmann, Claudia; Leibfritz, Dieter

2005-10-01

Multinuclear NMR spectroscopy is used to investigate the effect of glutamine on neuronal glucose metabolism. Primary neurons were incubated with [1-(13C)]glucose in the absence or presence of glutamine (2 mM) and/or NH4Cl (5 mM). After ammonia-treatment, the concentrations of high-energy phosphates decreased up to 84% of control, which was aggravated in glutamine-containing medium (up to 42% of control). These effects could not be attributed to changes in mitochondrial glucose oxidation. Withdrawal of glutamine decreased amino acid concentrations, e.g. of glutamate to 53%, but also considerably lessened the 13C enrichment in [4-(13C)]glutamate to 8.3% of control, and decreased the 13C-enrichment in acetyl-CoA entering the Krebs cycle (P < 0.001). Thus, although glutamine is potent in replenishing neuronal glutamate stores, glutamate formation is mainly attributed to its de novo synthesis from glucose. Furthermore, mitochondrial glucose metabolism strongly depends on the supply of carbons from glutamine, indicating that exogenous glutamine is a well-suited substrate to replenish neuronal Krebs cycle intermediates.

Feasibility study of a V-shaped pipe for passive aeration composting.

PubMed

Ogunwande, Gbolabo A

2011-03-01

A V-shaped (Vs) pipe was improvised for composting of chicken litter in passive aeration piles. Three piles, equipped with horizontal (Ho), vertical (Ve) and Vs pipes were set up. The three treatments were replicated thrice. The effects of the aeration pipe on the physico-chemical properties of chicken litter and air distribution within the composting piles were investigated during composting. The properties monitored were temperature, pH, electrical conductivity, moisture content, total carbon, total nitrogen, total phosphorus and carbon-to-nitrogen ratio. Moisture level in the piles was replenished fortnightly to 60% during composting. The results of the study showed that all the piles attained the optimum temperature range (40-65°C) for effective composting and satisfied the requirements for sanitation. The non-significant (p > 0.05) temperature difference within the piles with Ve and Vs pipes indicated that these pipes were effective for uniform air distribution within the pile. The aeration pipe had significant (p ≤ 0.05) effect on pile temperature, pre-replenishment moisture content, pH and total phosphorus. In conclusion, the study showed that the Vs pipe is feasible and effective for passive aeration composting.

Episodic-like memory in the rat.

PubMed

Babb, Stephanie J; Crystal, Jonathon D

2006-07-11

A fundamental question in comparative cognition is whether animals remember unique, personal past experiences. It has long been argued that memories for specific events (referred to as episodic memory) are unique to humans. Recently, considerable evidence has accumulated to show that food-storing birds possess critical behavioral elements of episodic memory, referred to as episodic-like memory in acknowledgment of the fact that behavioral criteria do not assess subjective experiences. Here we show that rats have a detailed representation of remembered events and meet behavioral criteria for episodic-like memory. We provided rats with access to locations baited with distinctive (e.g., grape and raspberry) or nondistinctive (regular chow) flavors. Locations with a distinctive flavor replenished after a long but not a short delay, and locations with the nondistinctive flavor never replenished. One distinctive flavor was devalued after encoding its location by prefeeding that flavor (satiation) or by pairing it with lithium chloride (acquired taste aversion), while the other distinctive flavor was not devalued. The rats selectively decreased revisits to the devalued distinctive flavor but not to the nondevalued distinctive flavor. The present studies demonstrate that rats selectively encode the content of episodic-like memories.

Multi-timescale analysis of a metabolic network in synthetic biology: a kinetic model for 3-hydroxypropionic acid production via beta-alanine.

PubMed

Dalwadi, Mohit P; King, John R; Minton, Nigel P

2018-07-01

A biosustainable production route for 3-hydroxypropionic acid (3HP), an important platform chemical, would allow 3HP to be produced without using fossil fuels. We are interested in investigating a potential biochemical route to 3HP from pyruvate through [Formula: see text]-alanine and, in this paper, we develop and solve a mathematical model for the reaction kinetics of the metabolites involved in this pathway. We consider two limiting cases, one where the levels of pyruvate are never replenished, the other where the levels of pyruvate are continuously replenished and thus kept constant. We exploit the natural separation of both the time scales and the metabolite concentrations to make significant asymptotic progress in understanding the system without resorting to computationally expensive parameter sweeps. Using our asymptotic results, we are able to predict the most important reactions to maximize the production of 3HP in this system while reducing the maximum amount of the toxic intermediate compound malonic semi-aldehyde present at any one time, and thus we are able to recommend which enzymes experimentalists should focus on manipulating.

Glucose Starvation Inhibits Autophagy via Vacuolar Hydrolysis and Induces Plasma Membrane Internalization by Down-regulating Recycling*

PubMed Central

Lang, Michael J.; Martinez-Marquez, Jorge Y.; Prosser, Derek C.; Ganser, Laura R.; Buelto, Destiney; Wendland, Beverly; Duncan, Mara C.

2014-01-01

Cellular energy influences all aspects of cellular function. Although cells can adapt to a gradual reduction in energy, acute energy depletion poses a unique challenge. Because acute depletion hampers the transport of new energy sources into the cell, the cell must use endogenous substrates to replenish energy after acute depletion. In the yeast Saccharomyces cerevisiae, glucose starvation causes an acute depletion of intracellular energy that recovers during continued glucose starvation. However, how the cell replenishes energy during the early phase of glucose starvation is unknown. In this study, we investigated the role of pathways that deliver proteins and lipids to the vacuole during glucose starvation. We report that in response to glucose starvation, plasma membrane proteins are directed to the vacuole through reduced recycling at the endosomes. Furthermore, we found that vacuolar hydrolysis inhibits macroautophagy in a target of rapamycin complex 1-dependent manner. Accordingly, we found that endocytosis and hydrolysis are required for survival in glucose starvation, whereas macroautophagy is dispensable. Together, these results suggest that hydrolysis of components delivered to the vacuole independent of autophagy is the cell survival mechanism used by S. cerevisiae in response to glucose starvation. PMID:24753258

Achieving Stable Radiation Pressure Acceleration of Heavy Ions via Successive Electron Replenishment from Ionization of a High-Z Material Coating

NASA Astrophysics Data System (ADS)

Qiao, Bin; Shen, X. F.; Zhang, H.; Kar, S.; Zhou, C. T.; Chang, H. X.; Borghesi, M.; He, X. T.

2017-10-01

Among various laser-driven acceleration schemes, radiation pressure acceleration (RPA) is regarded as one of the most promising schemes to obtain high-quality ion beams. Although RPA is very attractive in principle, it is difficult to be achieved experimentally. One of the most important reasons is the dramatic growth of the multi-dimensional Rayleigh-Taylor-like (RT) instabilities. In this talk, we report a novel method to achieve stable RPA of ions from laser-irradiated ultrathin foils, where a high-Z material coating in front is used. The coated high-Z material, acting as a moving electron repository, continuously replenishes the accelerating ion foil with comoving electrons in the light-sail acceleration stage due to its successive ionization under laser fields with Gaussian temporal profile. As a result, the detrimental effects such as electron loss induced by the RT and other instabilities are significantly offset and suppressed so that stable acceleration of ions are maintained. Supported by the NSAF, Grant No. U1630246; the NNSF China Grants No. 11575298; and the National Key Program of S&T Research and Development, Grant No. 2016YFA0401100.

Analysis of the single-vehicle cyclic inventory routing problem

NASA Astrophysics Data System (ADS)

Aghezzaf, El-Houssaine; Zhong, Yiqing; Raa, Birger; Mateo, Manel

2012-11-01

The single-vehicle cyclic inventory routing problem (SV-CIRP) consists of a repetitive distribution of a product from a single depot to a selected subset of customers. For each customer, selected for replenishments, the supplier collects a corresponding fixed reward. The objective is to determine the subset of customers to replenish, the quantity of the product to be delivered to each and to design the vehicle route so that the resulting profit (difference between the total reward and the total logistical cost) is maximised while preventing stockouts at each of the selected customers. This problem appears often as a sub-problem in many logistical problems. In this article, the SV-CIRP is formulated as a mixed-integer program with a nonlinear objective function. After a thorough analysis of the structure of the problem and its features, an exact algorithm for its solution is proposed. This exact algorithm requires only solutions of linear mixed-integer programs. Values of a savings-based heuristic for this problem are compared to the optimal values obtained for a set of some test problems. In general, the gap may get as large as 25%, which justifies the effort to continue exploring and developing exact and approximation algorithms for the SV-CIRP.

Achieving Stable Radiation Pressure Acceleration of Heavy Ions via Successive Electron Replenishment from Ionization of a High-Z Material Coating

NASA Astrophysics Data System (ADS)

Shen, X. F.; Qiao, B.; Chang, H. X.; Kar, S.; Zhou, C. T.; Borghesi, M.; He, X. T.

2016-10-01

Generation of monoenergetic heavy ion beams aroused more scientific interest in recent years. Radiation pressure acceleration (RPA) is an ideal mechanism for obtaining high-quality heavy ion beams, in principle. However, to achieve the same energy per nucleon (velocity) as protons, heavy ions undergo much more serious Rayleigh-Taylor-like (RT) instability and afterwards much worse Coulomb explosion due to loss of co-moving electrons. This leads to premature acceleration termination of heavy ions and very low energy attained in experiment. The utilization of a high-Z coating in front of the target may suppress the RT instability and Coulomb explosion by continuously replenishing the accelerating heavy ion foil with co-moving electrons due to its successive ionization under laser fields with Gaussian temporal and spatial profiles. Thus stable RPA can be realized. Two-dimensional and three-dimensional particles-in-cell simulations with dynamic ionization show that a monoenergetic Al13+ beam with peak energy 4.0GeV and particle number 1010 (charge > 20nC) can be obtained at intensity 1022 W/cm2. Supported by the NSF, Nos. 11575298 and 1000-Talents Program of China.

Refeeding syndrome as an unusual cause of anion gap metabolic acidosis.

PubMed

Singla, Manish; Perry, Alexandra; Lavery, Eric

2012-11-01

Refeeding syndrome is characterized by hypophosphatemia in the setting of malnutrition. It is commonly seen in patients with anorexia, alcoholism, or malignancy, and it is often a missed diagnosis. Because of the potential morbidity associated with missing the diagnosis of refeeding syndrome, it is important to monitor for this disease in any malnourished patient. We present a case of a 49-year-old male with chronic alcohol abuse who presented for alcohol detoxification and was found to have low phosphate, potassium, and magnesium on presentation, in addition to an elevated anion gap of unclear etiology. After extensive workup to evaluate the cause of his elevated anion gap and worsening of his electrolyte abnormalities despite replenishment, it was felt his symptoms were a result of refeeding syndrome. After oral intake was held and aggressive electrolyte replenishment was performed for 24 hours, the patient's anion gap closed and his electrolyte levels stabilized. This case demonstrates a unique presentation of refeeding syndrome given the patient's profound metabolic acidosis that provided a clue toward his eventual diagnosis. The standard workup for an anion gap metabolic acidosis was negative, and it was not until his refeeding syndrome had been treated that the anion gap closed.

Geothermal studies in the San Juan Basin and the Four Corners Area of the Colorado Plateau II. Steady-state models of the thermal source of the San Juan volcanic field

NASA Astrophysics Data System (ADS)

Reiter, Marshall; Clarkson, Gerry

1983-01-01

The increase of heat flow approaching the San Juan volcanic field depicts a smooth profile having a relatively large half width, perhaps 50-100 km. One may suggest thermal sources creating the observed anomaly at equivalent depths under, or in proximity to, the San Juan volcanic field. Although the cause of the increased heat flow approaching the San Juan field may be in part associated with more regional Southern Rocky Mountain tectonics; geologic, heat-flow, and seismic data support the idea of a separate thermal source associated with the San Juan volcanic field. It can be shown that cooling and solidification of very deep magma bodies (to 75 km) provide less heat than required by the observed anomaly. Replenishment of the thermal source causing the heat-flow anomaly is postulated. This replenishment is approximated in a limiting case by developing finite-difference steady-state models. The best models are consistent with a plume which rises from depths of at least 100 km to depths as shallow as 35 km, whose edge is about 10 km south of Durango.

DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment.

PubMed

Zhang, Teng; Oatley, Jon; Bardwell, Vivian J; Zarkower, David

2016-09-01

Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator of male sexual differentiation. Here we investigate the role of Dmrt1 in mouse spermatogonial stem cell (SSC) homeostasis. We find that Dmrt1 maintains SSCs during steady state spermatogenesis, where it regulates expression of Plzf, another transcription factor required for SSC maintenance. We also find that Dmrt1 is required for recovery of spermatogenesis after germ cell depletion. Committed progenitor cells expressing Ngn3 normally do not contribute to SSCs marked by the Id4-Gfp transgene, but do so when spermatogonia are chemically depleted using busulfan. Removal of Dmrt1 from Ngn3-positive germ cells blocks the replenishment of Id4-GFP-positive SSCs and recovery of spermatogenesis after busulfan treatment. Our data therefore reveal that Dmrt1 supports SSC maintenance in two ways: allowing SSCs to remain in the stem cell pool under normal conditions; and enabling progenitor cells to help restore the stem cell pool after germ cell depletion.

What is the role of autologous blood transfusion in major spine surgery?

PubMed

Kumar, Naresh; Chen, Yongsheng; Nath, Chinmoy; Liu, Eugene Hern Choon

2012-06-01

Major spine surgery is associated with significant blood loss, which has numerous complications. Blood loss is therefore an important concern when undertaking any major spine surgery. Blood loss can be addressed by reducing intraoperative blood loss and replenishing perioperative blood loss. Reducing intraoperative blood loss helps maintain hemodynamic equilibrium and provides a clearer operative field during surgery. Homologous blood transfusion is still the mainstay for replenishing blood loss in major spine surgery across the world, despite its known adverse effects. These significant adverse effects can be seen in up to 20% of patients. Autologous blood transfusion avoids the risks associated with homologous blood transfusion and has been shown to be cost-effective. This article reviews the different methods of autologous transfusion and focuses on the use of intraoperative cell salvage in major spine surgery. Autologous blood transfusion is a proven alternative to homologous transfusion in major spine surgery, avoiding most, if not all of these adverse effects. However, autologous blood transfusion rates in major spine surgery remain low across the world. Autologous blood transfusion may obviate the need for homologous transfusion completely. We encourage spine surgeons to consider autologous blood transfusion wherever feasible.

Joint Optimization of Distribution Network Design and Two-Echelon Inventory Control with Stochastic Demand and CO2 Emission Tax Charges.

PubMed

Li, Shuangyan; Li, Xialian; Zhang, Dezhi; Zhou, Lingyun

2017-01-01

This study develops an optimization model to integrate facility location and inventory control for a three-level distribution network consisting of a supplier, multiple distribution centers (DCs), and multiple retailers. The integrated model addressed in this study simultaneously determines three types of decisions: (1) facility location (optimal number, location, and size of DCs); (2) allocation (assignment of suppliers to located DCs and retailers to located DCs, and corresponding optimal transport mode choices); and (3) inventory control decisions on order quantities, reorder points, and amount of safety stock at each retailer and opened DC. A mixed-integer programming model is presented, which considers the carbon emission taxes, multiple transport modes, stochastic demand, and replenishment lead time. The goal is to minimize the total cost, which covers the fixed costs of logistics facilities, inventory, transportation, and CO2 emission tax charges. The aforementioned optimal model was solved using commercial software LINGO 11. A numerical example is provided to illustrate the applications of the proposed model. The findings show that carbon emission taxes can significantly affect the supply chain structure, inventory level, and carbon emission reduction levels. The delay rate directly affects the replenishment decision of a retailer.

The effect of motivation and positive affect on ego depletion: Replenishment versus release mechanism.

PubMed

Zhu, Ze; Li, Jian; Zhang, Bo; Li, Ye; Zhang, Houcan

2017-12-01

In this study, 2 experiments were conducted to investigate whether motivation and positive affect can alleviate ego depletion and to elucidate their possible mechanisms. In Experiment 1, a crossing-out-letter task was adapted to reach an ego depletion state for Chinese participants. Participants were then randomly assigned to the extrinsic motivation group, the positive affect group or the depletion control group. After the experimental treatment, a dumbbell task was used to measure participants' remaining self-regulatory resources. The results showed that participants in the motivation and positive affect groups performed better on the dumbbell task than participants in the depletion control group. Experiment 2 was similar to Experiment 1 except that participants were asked to perform an additional unexpected dumbbell task after a neutral video following the above procedure. The results of Experiment 1 were replicated; however, participants' performance on the additional dumbbell task differed. The positive affect group performed better than the depletion control group, indicating an increase in self-regulatory resources and thus supporting the replenishment effect of positive affect. No significant difference was found between the motivation group and the depletion control group. © 2015 International Union of Psychological Science.

Selling an Energy Efficiency Loan Portfolio in Oregon: Resale of the Craft3 loan portfolio to Self-Help Credit Union

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, Peter; Borgeson, Merrian; Kramer, Chris

Under the Clean Energy Works (CEW) program, Craft3 developed a loan product that widened access to financing for homeowners, offered long term funding, and collected repayments through the customer?s utility bill. The program?s success led Craft3 to pursue the sale of the loan portfolio to both mitigate its own risks and replenish funds for lending. This sale breaks new ground for energy efficiency finance and is notable as it was completed even with many novel program design elements. It replenished Craft3?s program capital and uncovered some valuable lessons that may facilitate future transactions. However, the lack of data history andmore » the unproven nature of the loan portfolio meant that Craft3 had to limit the risk of losses to Self-Help, the purchaser of the portfolio. It remains to be seen whether this experience will pave the way for more sales of on-bill energy efficiency loan portfolios. This case study illustrates how certain program design decisions can sometimes both facilitate programmatic objectives and possibly present challenges for the sale of a portfolio of energy efficiency loans.« less

Spatial-temporal three-dimensional ultrasound plane-by-plane active cavitation mapping for high-intensity focused ultrasound in free field and pulsatile flow.

PubMed

Ding, Ting; Hu, Hong; Bai, Chen; Guo, Shifang; Yang, Miao; Wang, Supin; Wan, Mingxi

2016-07-01

Cavitation plays important roles in almost all high-intensity focused ultrasound (HIFU) applications. However, current two-dimensional (2D) cavitation mapping could only provide cavitation activity in one plane. This study proposed a three-dimensional (3D) ultrasound plane-by-plane active cavitation mapping (3D-UPACM) for HIFU in free field and pulsatile flow. The acquisition of channel-domain raw radio-frequency (RF) data in 3D space was performed by sequential plane-by-plane 2D ultrafast active cavitation mapping. Between two adjacent unit locations, there was a waiting time to make cavitation nuclei distribution of the liquid back to the original state. The 3D cavitation map equivalent to the one detected at one time and over the entire volume could be reconstructed by Marching Cube algorithm. Minimum variance (MV) adaptive beamforming was combined with coherence factor (CF) weighting (MVCF) or compressive sensing (CS) method (MVCS) to process the raw RF data for improved beamforming or more rapid data processing. The feasibility of 3D-UPACM was demonstrated in tap-water and a phantom vessel with pulsatile flow. The time interval between temporal evolutions of cavitation bubble cloud could be several microseconds. MVCF beamformer had a signal-to-noise ratio (SNR) at 14.17dB higher, lateral and axial resolution at 2.88times and 1.88times, respectively, which were compared with those of B-mode active cavitation mapping. MVCS beamformer had only 14.94% time penalty of that of MVCF beamformer. This 3D-UPACM technique employs the linear array of a current ultrasound diagnosis system rather than a 2D array transducer to decrease the cost of the instrument. Moreover, although the application is limited by the requirement for a gassy fluid medium or a constant supply of new cavitation nuclei that allows replenishment of nuclei between HIFU exposures, this technique may exhibit a useful tool in 3D cavitation mapping for HIFU with high speed, precision and resolution, especially in a laboratory environment where more careful analysis may be required under controlled conditions. Copyright © 2016 Elsevier B.V. All rights reserved.

Rapid Inflation Caused by Shallow Magmatic Activities at Okmok Volcano, Alaska, Detected by GPS Campaigns 2000-2003

NASA Astrophysics Data System (ADS)

Miyagi, Y.; Freymueller, J.; Kimata, F.; Sato, T.; Mann, D.

2006-12-01

Okmok volcano is located on Umnak Island in the Aleutian Arc, Alaska. This volcano consists of a large caldera, and there are several post-caldera cones within the caldera. It has erupted more than 10 times during the last century, with the latest eruption occurring in February 1997. Annual GPS campaigns during 2000-2003 have revealed a rapid inflation at Okmok volcano. Surface deformation indicates that Okmok volcano has been inflating during 2000-2003 at a variable inflation rate. Total displacements over three years are as large as 15 cm of maximum radial displacement and more than 35 cm of maximum uplift. Simple inflation pattern after 2001, showing radial outward displacements from the caldera center and significant uplifts, are modeled by a Mogi inflation source, which is located at the depth of about 3.1 km beneath the geometric center of the caldera, and we interpreted the source as a shallow magma chamber. The results from our GPS measurements correspond approximately to the results from InSAR measurement for almost same periods, except for an underestimate of the volume change rate of the source deduced by InSAR data for the period 2002-2003. Taking into consideration the results from InSAR measurements, the amount of volume increase in the source is estimated to be about 0.028 km3 during 1997-2003. This means that 20-54 percent of the volume erupted in the 1997 eruption has been already replenished in the shallow magma chamber. An eruption recurrence time is estimated from the volume change rate of the source to be about 15-30 years for 1997-sized eruptions, which is consistent with about 25 years average time interval between major eruptions at Okmok volcano. An additional modeling using a rectangular tensile source combined to the main spherical source suggests a possibility of other magma storage located between the main source and the active vent, which is associated with lateral magma transportation between them. The combined model improved residuals compared to those from single-source model, and provided significantly better fitting to the deformation data inside the caldera.

Fuzzy interval Finite Element/Statistical Energy Analysis for mid-frequency analysis of built-up systems with mixed fuzzy and interval parameters

NASA Astrophysics Data System (ADS)

Yin, Hui; Yu, Dejie; Yin, Shengwen; Xia, Baizhan

2016-10-01

This paper introduces mixed fuzzy and interval parametric uncertainties into the FE components of the hybrid Finite Element/Statistical Energy Analysis (FE/SEA) model for mid-frequency analysis of built-up systems, thus an uncertain ensemble combining non-parametric with mixed fuzzy and interval parametric uncertainties comes into being. A fuzzy interval Finite Element/Statistical Energy Analysis (FIFE/SEA) framework is proposed to obtain the uncertain responses of built-up systems, which are described as intervals with fuzzy bounds, termed as fuzzy-bounded intervals (FBIs) in this paper. Based on the level-cut technique, a first-order fuzzy interval perturbation FE/SEA (FFIPFE/SEA) and a second-order fuzzy interval perturbation FE/SEA method (SFIPFE/SEA) are developed to handle the mixed parametric uncertainties efficiently. FFIPFE/SEA approximates the response functions by the first-order Taylor series, while SFIPFE/SEA improves the accuracy by considering the second-order items of Taylor series, in which all the mixed second-order items are neglected. To further improve the accuracy, a Chebyshev fuzzy interval method (CFIM) is proposed, in which the Chebyshev polynomials is used to approximate the response functions. The FBIs are eventually reconstructed by assembling the extrema solutions at all cut levels. Numerical results on two built-up systems verify the effectiveness of the proposed methods.

Using Screencast Videos to Enhance Undergraduate Students' Statistical Reasoning about Confidence Intervals

ERIC Educational Resources Information Center

Strazzeri, Kenneth Charles

2013-01-01

The purposes of this study were to investigate (a) undergraduate students' reasoning about the concepts of confidence intervals (b) undergraduate students' interactions with "well-designed" screencast videos on sampling distributions and confidence intervals, and (c) how screencast videos improve undergraduate students' reasoning ability…

Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae.

PubMed

Maziarz, Marcin; Shevade, Aishwarya; Barrett, LaKisha; Kuchin, Sergei

2016-07-01

Glucose is the preferred carbon source for the yeast Saccharomyces cerevisiae Glucose limitation activates Snf1 protein kinase, a key regulator of energy homeostasis that promotes utilization of alternative carbon sources and enforces energy conservation. Snf1 activation requires phosphorylation of its T-loop threonine (Thr210) by upstream kinases. When glucose is abundant, Snf1 is inhibited by Thr210 dephosphorylation. This involves the function of the type 1 protein phosphatase Glc7, which is targeted to Snf1 by a regulatory subunit, Reg1. The reg1 mutation causes increased Snf1 activity and mimics various aspects of glucose limitation, including slower growth. Reg2 is another Glc7 regulatory subunit encoded by a paralogous gene, REG2 Previous evidence indicated that the reg2 mutation exacerbates the Snf1-dependent slow-growth phenotype caused by reg1, suggesting a link between Reg2 and Snf1. Here, we explore this link in more detail and present evidence that Reg2 contributes to Snf1 Thr210 dephosphorylation. Consistent with this role, Reg2 interacts with wild-type Snf1 but not with nonphosphorylatable Snf1-T210A. Reg2 accumulation increases in a Snf1-dependent manner during prolonged glucose deprivation, and glucose-starved cells lacking Reg2 exhibit delayed Snf1 Thr210 dephosphorylation and slower growth recovery upon glucose replenishment. Accordingly, cells lacking Reg2 are outcompeted by wild-type cells in the course of several glucose starvation/replenishment cycles. Collectively, our results support a model in which Reg2-Glc7 contributes to the negative control of Snf1 in response to glucose refeeding after prolonged starvation. The competitive growth advantage provided by Reg2 underscores the evolutionary significance of this paralog for S. cerevisiae The ability of microorganisms to respond to stress is essential for their survival. However, rapid recovery from stress could be equally crucial in competitive environments. Therefore, a wise stress response program should prepare cells for quick recovery upon reexposure to favorable conditions. Glucose is the preferred carbon source for the yeast S. cerevisiae Glucose depletion activates the stress response protein kinase Snf1, which functions to limit energy-consuming processes, such as growth. We show that prolonged glucose deprivation also leads to Snf1-dependent accumulation of Reg2 and that this protein helps to inhibit Snf1 and to accelerate growth recovery upon glucose replenishment. Cells lacking Reg2 are readily outcompeted by wild-type cells during glucose depletion/replenishment cycles. Thus, while prolonged glucose deprivation might seem to put yeast cells "on their knees," concomitant accumulation of Reg2 helps configure the cells into a "sprinter's crouch start position" to spring into action once glucose becomes available. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae

PubMed Central

Maziarz, Marcin; Shevade, Aishwarya; Barrett, LaKisha

2016-01-01

ABSTRACT Glucose is the preferred carbon source for the yeast Saccharomyces cerevisiae. Glucose limitation activates Snf1 protein kinase, a key regulator of energy homeostasis that promotes utilization of alternative carbon sources and enforces energy conservation. Snf1 activation requires phosphorylation of its T-loop threonine (Thr210) by upstream kinases. When glucose is abundant, Snf1 is inhibited by Thr210 dephosphorylation. This involves the function of the type 1 protein phosphatase Glc7, which is targeted to Snf1 by a regulatory subunit, Reg1. The reg1 mutation causes increased Snf1 activity and mimics various aspects of glucose limitation, including slower growth. Reg2 is another Glc7 regulatory subunit encoded by a paralogous gene, REG2. Previous evidence indicated that the reg2 mutation exacerbates the Snf1-dependent slow-growth phenotype caused by reg1, suggesting a link between Reg2 and Snf1. Here, we explore this link in more detail and present evidence that Reg2 contributes to Snf1 Thr210 dephosphorylation. Consistent with this role, Reg2 interacts with wild-type Snf1 but not with nonphosphorylatable Snf1-T210A. Reg2 accumulation increases in a Snf1-dependent manner during prolonged glucose deprivation, and glucose-starved cells lacking Reg2 exhibit delayed Snf1 Thr210 dephosphorylation and slower growth recovery upon glucose replenishment. Accordingly, cells lacking Reg2 are outcompeted by wild-type cells in the course of several glucose starvation/replenishment cycles. Collectively, our results support a model in which Reg2-Glc7 contributes to the negative control of Snf1 in response to glucose refeeding after prolonged starvation. The competitive growth advantage provided by Reg2 underscores the evolutionary significance of this paralog for S. cerevisiae. IMPORTANCE The ability of microorganisms to respond to stress is essential for their survival. However, rapid recovery from stress could be equally crucial in competitive environments. Therefore, a wise stress response program should prepare cells for quick recovery upon reexposure to favorable conditions. Glucose is the preferred carbon source for the yeast S. cerevisiae. Glucose depletion activates the stress response protein kinase Snf1, which functions to limit energy-consuming processes, such as growth. We show that prolonged glucose deprivation also leads to Snf1-dependent accumulation of Reg2 and that this protein helps to inhibit Snf1 and to accelerate growth recovery upon glucose replenishment. Cells lacking Reg2 are readily outcompeted by wild-type cells during glucose depletion/replenishment cycles. Thus, while prolonged glucose deprivation might seem to put yeast cells “on their knees,” concomitant accumulation of Reg2 helps configure the cells into a “sprinter's crouch start position” to spring into action once glucose becomes available. PMID:27107116

Optimization of the Reconstruction Interval in Neurovascular 4D-CTA Imaging

PubMed Central

Hoogenboom, T.C.H.; van Beurden, R.M.J.; van Teylingen, B.; Schenk, B.; Willems, P.W.A.

2012-01-01

Summary Time resolved whole brain CT angiography (4D-CTA) is a novel imaging technology providing information regarding blood flow. One of the factors that influence the diagnostic value of this examination is the temporal resolution, which is affected by the gantry rotation speed during acquisition and the reconstruction interval during post-processing. Post-processing determines the time spacing between two reconstructed volumes and, unlike rotation speed, does not affect radiation burden. The data sets of six patients who underwent a cranial 4D-CTA were used for this study. Raw data was acquired using a 320-slice scanner with a rotation speed of 2 Hz. The arterial to venous passage of an intravenous contrast bolus was captured during a 15 s continuous scan. The raw data was reconstructed using four different reconstruction-intervals: 0.2, 0.3, 0.5 and 1.0 s. The results were rated by two observers using a standardized score sheet. The appearance of each lesion was rated correctly in all readings. Scoring for quality of temporal resolution revealed a stepwise improvement from the 1.0 s interval to the 0.3 s interval, while no discernable improvement was noted between the 0.3 s and 0.2 s interval. An increase in temporal resolution may improve the diagnostic quality of cranial 4D-CTA. Using a rotation speed of 0.5 s, the optimal reconstruction interval appears to be 0.3 s, beyond which, changes can no longer be discerned. PMID:23217631

Effects of High Intensity Interval Training and Strength Training on Metabolic, Cardiovascular and Hormonal Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Study.

PubMed

Almenning, Ida; Rieber-Mohn, Astrid; Lundgren, Kari Margrethe; Shetelig Løvvik, Tone; Garnæs, Kirsti Krohn; Moholdt, Trine

2015-01-01

Polycystic ovary syndrome is a common endocrinopathy in reproductive-age women, and associates with insulin resistance. Exercise is advocated in this disorder, but little knowledge exists on the optimal exercise regimes. We assessed the effects of high intensity interval training and strength training on metabolic, cardiovascular, and hormonal outcomes in women with polycystic ovary syndrome. Three-arm parallel randomized controlled trial. Thirty-one women with polycystic ovary syndrome (age 27.2 ± 5.5 years; body mass index 26.7 ± 6.0 kg/m2) were randomly assigned to high intensity interval training, strength training, or a control group. The exercise groups exercised three times weekly for 10 weeks. The main outcome measure was change in homeostatic assessment of insulin resistance (HOMA-IR). HOMA-IR improved significantly only after high intensity interval training, by -0.83 (95% confidence interval [CI], -1.45, -0.20), equal to 17%, with between-group difference (p = 0.014). After high intensity interval training, high-density lipoprotein cholesterol increased by 0.2 (95% CI, 0.02, 0.5) mmol/L, with between group difference (p = 0.04). Endothelial function, measured as flow-mediated dilatation of the brachial artery, increased significantly after high intensity interval training, by 2.0 (95% CI, 0.1, 4.0) %, between-group difference (p = 0.08). Fat percentage decreased significantly after both exercise regimes, without changes in body weight. After strength training, anti-Müllarian hormone was significantly reduced, by -14.8 (95% CI, -21.2, -8.4) pmol/L, between-group difference (p = 0.04). There were no significant changes in high-sensitivity C-reactive protein, adiponectin or leptin in any group. High intensity interval training for ten weeks improved insulin resistance, without weight loss, in women with polycystic ovary syndrome. Body composition improved significantly after both strength training and high intensity interval training. This pilot study indicates that exercise training can improve the cardiometabolic profile in polycystic ovary syndrome in the absence of weight loss. ClinicalTrial.gov NCT01919281.

2007 SB14 Source Reduction Plan/Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, L

2007-07-24

Aqueous solutions (mixed waste) generated from various LLNL operations, such as debris washing, sample preparation and analysis, and equipment maintenance and cleanout, were combined for storage in the B695 tank farm. Prior to combination the individual waste streams had different codes depending on the particular generating process and waste characteristics. The largest streams were CWC 132, 791, 134, 792. Several smaller waste streams were also included. This combined waste stream was treated at LLNL's waste treatment facility using a vacuum filtration and cool vapor evaporation process in preparation for discharge to sanitary sewer. Prior to discharge, the treated waste streammore » was sampled and the results were reviewed by LLNL's water monitoring specialists. The treated solution was discharged following confirmation that it met the discharge criteria. A major source, accounting for 50% for this waste stream, is metal machining, cutting and grinding operations in the engineering machine shops in B321/B131. An additional 7% was from similar operations in B131 and B132S. This waste stream primarily contains metal cuttings from machined parts, machining coolant and water, with small amounts of tramp oil from the machining and grinding equipment. Several waste reduction measures for the B321 machine shop have been taken, including the use of a small point-of-use filtering/tramp-oil coalescing/UV-sterilization coolant recycling unit, and improved management techniques (testing and replenishing) for coolants. The recycling unit had some operational problems during 2006. The machine shop is planning to have it repaired in the near future. A major source, accounting for 50% for this waste stream, is metal machining, cutting and grinding operations in the engineering machine shops in B321/B131. An additional 7% was from similar operations in B131 and B132S. This waste stream primarily contains metal cuttings from machined parts, machining coolant and water, with small amounts of tramp oil from the machining and grinding equipment. Several waste reduction measures for the B321 machine shop have been taken, including the use of a small point-of-use filtering/tramp-oil coalescing/UV-sterilization coolant recycling unit, and improved management techniques (testing and replenishing) for coolants. The recycling unit had some operational problems during 2006. The machine shop is planning to have it repaired in the near future. Quarterly waste generation data prepared by the Environmental Protection Department's P2 Team are regularly provided to engineering shops as well as other facilities so that generators can track the effectiveness of their waste minimization efforts.« less

Fourier-transform infrared derivative spectroscopy with an improved signal-to-noise ratio.

PubMed

Fetterman, M R

2005-09-01

Infrared derivative spectroscopy is a useful technique for finding peaks hidden in broad spectral features. A data acquisition technique is shown that will improve the signal-to-noise ratio (SNR) of Fourier-transform infrared (FTIR) derivative spectroscopy. Typically, in a FTIR measurement one samples each point for the same time interval. The effect of using a graded time interval is studied. The simulations presented show that the SNR of first-derivative FTIR spectroscopy will improve by 15% and that the SNR of second-derivative FTIR will improve by 34%.

Nectar Robbing Positively Influences the Reproductive Success of Tecomella undulata (Bignoniaceae)

PubMed Central

Singh, Vineet Kumar; Barman, Chandan; Tandon, Rajesh

2014-01-01

The net consequence of nectar robbing on reproductive success of plants is usually negative and the positive effect is rarely produced. We evaluated the influence of nectar robbing on the behaviour of pollinators and the reproductive success of Tecomella undulata (Bignoniaceae) in a natural population. Experimental pollinations showed that the trees were strictly self-incompatible. The three types of floral colour morphs of the tree viz. red, orange and yellow, lacked compatibility barriers. The pollinators (Pycnonotus cafer and Pycnonotus leucotis) and the robber (Nectarinia asiatica) showed equal preference for all the morphs, as they visited each morph with nearly equal frequency and flower-handling time. The sunbirds caused up to 60% nectar robbing, mostly (99%) by piercing through the corolla tube. Although nectar is replenished at regular intervals, insufficient amount of nectar compelled the pollinators to visit additional trees in bloom. Data of manual nectar robbing from the entire tree showed that the pollinators covered lower number of flowers per tree (5 flowers/tree) and more trees per bout (7 trees/bout) than the unrobbed ones (19 flowers/tree and 2 trees bout). The robbed trees set a significantly greater amount of fruits than the unrobbed trees. However, the number of seeds in a fruit did not differ significantly. The study shows that plant-pollinator-robber interaction may benefit the self-incompatible plant species under conditions that increases the visits of pollinators among the compatible conspecifics in a population. PMID:25036554

Nectar robbing positively influences the reproductive success of Tecomella undulata (Bignoniaceae).

PubMed

Singh, Vineet Kumar; Barman, Chandan; Tandon, Rajesh

2014-01-01

The net consequence of nectar robbing on reproductive success of plants is usually negative and the positive effect is rarely produced. We evaluated the influence of nectar robbing on the behaviour of pollinators and the reproductive success of Tecomella undulata (Bignoniaceae) in a natural population. Experimental pollinations showed that the trees were strictly self-incompatible. The three types of floral colour morphs of the tree viz. red, orange and yellow, lacked compatibility barriers. The pollinators (Pycnonotus cafer and Pycnonotus leucotis) and the robber (Nectarinia asiatica) showed equal preference for all the morphs, as they visited each morph with nearly equal frequency and flower-handling time. The sunbirds caused up to 60% nectar robbing, mostly (99%) by piercing through the corolla tube. Although nectar is replenished at regular intervals, insufficient amount of nectar compelled the pollinators to visit additional trees in bloom. Data of manual nectar robbing from the entire tree showed that the pollinators covered lower number of flowers per tree (5 flowers/tree) and more trees per bout (7 trees/bout) than the unrobbed ones (19 flowers/tree and 2 trees bout). The robbed trees set a significantly greater amount of fruits than the unrobbed trees. However, the number of seeds in a fruit did not differ significantly. The study shows that plant-pollinator-robber interaction may benefit the self-incompatible plant species under conditions that increases the visits of pollinators among the compatible conspecifics in a population.

Diurnal changes in net uptake rate of nitrate are associated with changes in estimated export of carbohydrates to roots

NASA Technical Reports Server (NTRS)

Rideout, J. W.; Raper, C. D. Jr; Raper CD, J. r. (Principal Investigator)

1994-01-01

The rate of NO3- uptake by soybean (Glycine max [L.] Merrill) roots generally declines during the night in association with progressive depletion of the nonstructural carbohydrate pool in the shoot as well as the concentration of carbohydrates in roots. To determine if NO3- uptake rate changes in response to variations in translocation rate of carbohydrates from shoot to roots per se or to carbohydrate status of the roots, the night period was interrupted with a low light level from incandescent lamps to alter the diurnal pattern of NO3- uptake by roots and export of carbohydrate from shoots of nonnodulated soybean. Depletion of NO3- from replenished, complete nutrient solutions containing 1 mM NO3- was measured by ion chromatography and rates of NO3- uptake were calculated. Changes in export of carbohydrates from shoot to roots during intervals of the night period were calculated as the differences between rates of disappearance in contents of nonstructural carbohydrates and their estimated rates of utilization in shoot respiration and growth. A positive, significant correlation occurred between changes in calculated rates of carbohydrate export from shoots and NO3- uptake rates. Conversely, there was no significant correlation between concentrations of nonstructural carbohydrates in roots and NO3- uptake rates. These results support the hypothesis that carbohydrate flux from shoot to roots has a direct role in regulation of nitrogen uptake by the whole plant.

Numerical model of the evolution of asteroid orbits at the 2:5 resonance

NASA Astrophysics Data System (ADS)

Ipatov, S. I.

1992-12-01

The interrelations of the variations in the orbital elements of asteroids at the 2:5 resonance and in its vicinity are investigated.. These investigations are based on the numerical integration of the complete equations of motion of the three-body problem (sun-Jupiter-asteroid) for 500 model asteroids. The time interval under consideration for most versions of the calculations equaled 10(4) orbital periods of Jupiter. The limits of the variations in the orbital elements and the regions of initial data corresponding to different types of interrelations of the variations in the eccentricity and longitude of perihelion are examined. It is shown that thr 2:5 gap may play a larger role than other gaps in the replenishment of the Apollo and Amor groups. The time over which the argument of perihelion changed by 360 degrees was usually equal to two periods of variation in the orbital inclination. When this interrelation was not found, the time over which the longitude of the ascending node changed by 360 degrees was equal, as a rule, to one period of variation in this inclination. For some asteroids moving along orbits of small eccentricity and inclination, interrelations were found between the periods of variation in four orbital elements: eccentricity, inclination, argument of perihelion, and longitude of the ascending node. For initial inclinations i° = 40° of asteroid orbits, the maximum values of inclinations of some model asteroids reached 160 degrees. Such asteroids could reach the sun or nearly parabolic orbits.

Applying a regional hydrology model to evaluate locations for groundwater replenishment with hillslope runoff under different climate and land use scenarios in an agricultural basin, central coastal California

NASA Astrophysics Data System (ADS)

Beganskas, S.; Young, K. S.; Fisher, A. T.; Lozano, S.; Harmon, R. E.; Teo, E. K.

2017-12-01

We are applying a regional hydrology model, Precipitation-Runoff Modeling System (PRMS), to evaluate locations for groundwater replenishment with hillslope runoff in the Pajaro Valley Groundwater Basin (PVGB), central coastal California. Stormwater managed aquifer recharge (MAR) projects collect hillslope runoff before it reaches a stream and infiltrate it into underlying aquifers, improving groundwater supply. The PVGB is a developed agricultural basin where groundwater provides >85% of water for irrigation and municipal needs; stormwater-MAR projects are being considered to address chronic overdraft and saltwater intrusion. We are applying PRMS to assess on a subwatershed scale (10-100 ha; 25-250 acres) where adequate runoff is generated to supply stormwater-MAR in coincidence with suitable conditions for infiltration and recharge. Data from active stormwater-MAR projects in the PVGB provide ground truth for model results. We are also examining how basinwide hydrology responds to changing land use and climate, and the potential implications for future water management. To prepare extensive input files for PRMS models, we developed ArcGIS and Python tools to delineate a topographic model grid and incorporate high-resolution soil, vegetation, and other physical data into each grid region; we also developed tools to analyze and visualize model output. Using historic climate records, we generated dry, normal, and wet climate scenarios, defined as having approximately 25th, 50th, and 75th percentile annual rainfall, respectively. We also generated multiple land use scenarios by replacing developed areas with native vegetation. Preliminary results indicate that many parts of the PVGB generate significant runoff and have suitable infiltration/recharge conditions. Reducing basinwide overdraft by 10% would require collecting less than 5% of total hillslope runoff, even during the dry scenario; this demonstrates that stormwater-MAR could be an effective water management strategy under a broad range of future climate conditions. The tools we have developed inform the placement and design of stormwater-MAR projects that make effective use of limited resources.

Prospects for Groundwater Drought Termination in the UK in 2017-18

NASA Astrophysics Data System (ADS)

Parry, S.; McKenzie, A.; Prudhomme, C.; Wilby, R.; Wood, P.

2017-12-01

The recovery of groundwater levels towards the end of a drought can lag behind surface water stores such as reservoirs or snowpack - as was the case for California in 2016/17. Groundwater replenishment is an important precursor to the ending of water restrictions, and an improved understanding of the range of plausible groundwater recovery scenarios would be useful for a range of stakeholders, including water managers, farmers and businesses. A method for characterising drought termination in hydrological data is applied systematically here to long time series of groundwater levels (some from the mid-1800s) for the UK. This analysis capitalises on the comprehensive perspective of post-drought recovery in the historical record to provide various outlooks of recovery in groundwater levels over seasonal to multi-year timeframes and to better understand how present conditions are likely to evolve. Rainfall deficiencies in the UK since summer 2016 limited replenishment during the 2016/17 winter recharge season. As a consequence, groundwater levels in south-east England were notably below normal in summer 2017. The possibility of an abrupt termination as occurred in 2012 can already be excluded, and extrapolating recent patterns suggests that very gradual recoveries may be underway. At many sites, normal conditions are not expected to return during 2017, and later still for sites in less responsive aquifers. This is supported by the multi-year drought durations typically found in the historical record, much more prolonged than those observed during the currently developing event. The rainfall rates that have driven historical drought termination events are also assessed for their likelihood across a range of timeframes and start months. Overall results underline the importance of the typical recharge season during the wetter winter half-year in averting multi-year groundwater drought events that would threaten water resources in the populous south-east of the UK. The approach adopted in this study could complement existing operational tools which provide outlooks for groundwater levels over seasonal to annual timescales, such as the UK Hydrological Outlook. The drought termination metrics are also applicable to surface water and hydrological contexts beyond the UK.

K-12 Finance a Top Priority in '05 Sessions: States Feeling Pressure from Competing Needs

ERIC Educational Resources Information Center

Hoff, David J.

2005-01-01

Good fiscal news is arriving in state capitals: Tax revenues are finally starting to recover from their four-year swoon. The bad news: States face pressure to meet increasing health-care costs and to replenish rainy-day and other funds legislatures tapped in recent years. The bottom line is that schools will have to fight for significant increases…

A Further Examination of Operational Availability in Life Cycle Cost Models

DTIC Science & Technology

1984-09-01

FI) (F3) (F40) where: FI is the number of aircraft ( PfA ) F3 is flying hours per PAA per year ( FH/PAAY’R ) F40 is replenishment spares cost per flying... Salem (ir’eg O 97302 UNCLASSUIEXD SECUI..JTY C -Ab.IFIA) ION OF ’.’HS PAGE RE PORT DOCUMENTATION PAGE~ la, REPORT SECURITY CLASSI (ICArION lb

Direct carbon fuel cell and stack designs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorte, Raymond J.; Oh, Tae-Sik

Disclosed are novel configurations of Direct Carbon Fuel Cells (DCFCs), which optionally comprise a liquid anode. The liquid anode comprises a molten salt/metal, preferably Sb, and a fuel, which has significant elemental carbon content (coal, bio-mass, etc.). The supply of fuel is continuously replenished in the anode. In addition, a stack configuration is suggested where combining a large number of planar or tubular fuel elements.

Building a 600-Ship Navy: Costs, Time, and Alternative Approaches

DTIC Science & Technology

1982-03-01

distributed-force operations but not currently included in Navy construction plans. These include 12 guided missile aviation cruisers ( CGV ) and 61...guided missile destroyers (DDGY). The CGVs would be equipped With a balanced suite of ship- mounted anti-air, antisubmarine, and antisurface weapons... CGV ) with extensive facilities for supporting V/STOL aircraft. These cruisers would operate with surface action groups and underway replenishment

Saproxylic beetles in a Swedish boreal forest landscape managed according to 'new forestry'

Treesearch

Stig Larsson; Barbara Ekbom; L. Martin Schroeder; Melodie A. McGeoch

2006-01-01

A major threat to biodiversity in Swedish forests is the decline of Coarse Woody Debris (CWD), which is an essential resource for many organisms and plays an essential role for the structure and function of boreal forests. Removal of CWD in commercial forestry has depleted important resources for many rare wood-living (saproxylic) beetles. Replenishment of CWD has been...

Streamlining the supply chain.

PubMed

Neumann, Lydon

2003-07-01

Effective management of the supply chain requires attention to: Product management--formulary development and maintenance, compliance, clinical involvement, standardization, and demand-matching. Sourcing and contracting--vendor consolidation, GPO portfolio management, price leveling, content management, and direct contracting Purchasing and payment-cycle--automatic placement, web enablement, centralization, evaluated receipts settlement, and invoice matching Inventory and distribution management--"unofficial" and "official" locations, vendor-managed inventory, automatic replenishment, and freight management.

Actin-filament disassembly: it takes two to shrink them fast.

PubMed

Winterhoff, Moritz; Faix, Jan

2015-06-01

Actin-filament disassembly is indispensable for replenishing the pool of polymerizable actin and allows continuous dynamic remodelling of the actin cytoskeleton. A new study now reveals that ADF/cofilin preferentially dismantles branched networks and provides new insights into the collaborative work of ADF/cofilin and Aip1 on filament disassembly at the molecular level. Copyright © 2015 Elsevier Ltd. All rights reserved.

Passing the Torch by Passing on a Skill: Passing the Torch to the Next Generation is the Intrinsic Reward for Dedicated Technology Teachers

ERIC Educational Resources Information Center

Millson, David; Jerie, Branko

2005-01-01

Motivating students to master the basics in any field is a demanding task. In technical education, while the direct benefit--almost certain, well-paying employment--is obvious, the challenge is to keep students' interest high. Absent that, the technical workforce lacks skilled replenishment, and the possibility of being overtaken by competition…

Enhancing Incentive Programs with Proximal Goals and Immediate Feedback: Engineered Labor Standards and Technology Enhancements in Stocker Replenishment

ERIC Educational Resources Information Center

Goomas, David T.; Ludwig, Timothy D.

2007-01-01

Under baseline conditions warehouse stockers (n = 23) could earn incentives if their team performed above the team quota of 18 cases stocked per hour. They were also subject to disciplinary action if they failed to regularly meet individual stocking quotas. In spite of these contingencies the stockers failed to receive bonus payments most of the…

China Moves Out: Stepping Stones Toward a New Maritime Strategy

DTIC Science & Technology

2015-04-01

that participated in the exercise deployed to Pakistan without replenishing food stores, although they did take on fuel.59 Press reporting on the...carried out more than 10 combat-realistic training tasks, including the anti-pirate, joint search and rescue, anti- nuclear and anti-chemical contamination ... Malaysia ) Taiwan Senkaku (Japan) Scarborough (Philippines) James Shoal ( Malaysia ) Table 4. Evolution of PLAN Western Pacific Deployments 36 China

Simulation of Aircraft Deployment Support

DTIC Science & Technology

2003-03-01

Dassault Aviation Military Customer Support Division 78, Quai Marcel Dassault Cedex 300 92552 St Cloud Cedex France Tel.: 33 147 1163 23 Fax.: 33 147...Deployment Support" (SADS) was developed by the Military Customer Support Division of Dassault Aviation to perform simulations for logistics deployment and...and support Chain Management for the management of the logistics resources (replenishment of consumables and repair of parts, inventory management

East Europe Report, Economic and Industrial Affairs, No. 2394

DTIC Science & Technology

1983-04-28

been designated to replenish the sowing stocks of private farmers. The requirement for the fodder plant seeds is estimated at 4,600 tons. The Plant ...Interview Lublin Area January Inventory Results, by Stanislaw Ozonek Winter Crops, Spring Planting Olsztyn Area Spring Preparations YUGOSLAVIA...country. The Seventh Plenum of the CPCZ Central Committee in November 1982 designated foreign economic relations as one of the priorities of party

Vented Chill / No-Vent Fill of Cryogenic Propellant Tanks

NASA Technical Reports Server (NTRS)

Rhys, Noah O.; Foster, Lee W.; Martin, Adam K.; Stephens, Jonathan R.

2016-01-01

Architectures for extended duration missions often include an on-orbit replenishment of the space vehicle's cryogenic liquid propellants. Such a replenishment could be accomplished via a tank-to-tank transfer from a dedicated tanker or a more permanent propellant depot storage tank. Minimizing the propellant loss associated with transfer line and receiver propellant tank thermal conditioning is essential for mass savings. A new methodology for conducting tank-to-tank transfer while minimizing such losses has been demonstrated. Charge-Hold-Vent is the traditional methodology for conducting a tank-to-tank propellant transfer. A small amount of cryogenic liquid is introduced to chill the transfer line and propellant tank. As the propellant absorbs heat and undergoes a phase change, the tank internal pressure increases. The tank is then vented to relieve pressure prior to another charge of cryogenic liquid being introduced. This cycle is repeated until the transfer lines and tank are sufficiently chilled and the replenishment of the propellant tank is complete. This method suffers inefficiencies due to multiple chill and vent cycles within the transfer lines and associated feed system components. Additionally, this system requires precise measuring of cryogenic fluid delivery for each transfer, multiple valve cycling events, and other complexities associated with cycled operations. To minimize propellant loss and greatly simplify on-orbit operations, an alternate methodology has been designed and demonstrated. The Vented Chill / No Vent Fill method is a simpler, constant flow approach in which the propellant tank and transfer lines are only chilled once. The receiver tank is continuously vented as cryogenic liquid chills the transfer lines, tank mass and ullage space. Once chilled sufficiently, the receiver tank valve is closed and the tank is completely filled. Interestingly, the vent valve can be closed prior to receiver tank components reaching liquid saturation temperature. An incomplete fill results if insufficient energy is removed from the tank's thermal mass and ullage space. The key to successfully conducting the no vent fill is to assure that sufficient energy is removed from the system prior to closing the receiver tank vent valve. This paper will provide a description of the transfer methodology and test article, and will provide a discussion of test results.

Activity Induces Fmr1-Sensitive Synaptic Capture of Anterograde Circulating Neuropeptide Vesicles.

PubMed

Cavolo, Samantha L; Bulgari, Dinara; Deitcher, David L; Levitan, Edwin S

2016-11-16

Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out of the nerve terminal. Activity increases DCV capture to rapidly replenish synaptic neuropeptide stores following release. However, it is not known whether this is due to enhanced bidirectional capture. Here experiments at the Drosophila neuromuscular junction, where DCVs contain neuropeptides and a bone morphogenic protein, show that activity-dependent replenishment of synaptic neuropeptides following release is evident after inhibiting the retrograde transport with the dynactin disruptor mycalolide B or photobleaching DCVs entering a synaptic bouton by retrograde transport. In contrast, photobleaching anterograde transport vesicles entering a bouton inhibits neuropeptide replenishment after activity. Furthermore, tracking of individual DCVs moving through boutons shows that activity selectively increases capture of DCVs undergoing anterograde transport. Finally, upregulating fragile X mental retardation 1 protein (Fmr1, also called FMRP) acts independently of futsch/MAP-1B to abolish activity-dependent, but not constitutive, capture. Fmr1 also reduces presynaptic neuropeptide stores without affecting activity-independent delivery and evoked release. Therefore, presynaptic motoneuron neuropeptide storage is increased by a vesicle capture mechanism that is distinguished from constitutive bidirectional capture by activity dependence, anterograde selectivity, and Fmr1 sensitivity. These results show that activity recruits a separate mechanism than used at rest to stimulate additional synaptic capture of DCVs for future release of neuropeptides and neurotrophins. Synaptic release of neuropeptides and neurotrophins depends on presynaptic accumulation of dense-core vesicles (DCVs). At rest, DCVs are captured bidirectionally as they circulate through Drosophila motoneuron terminals by anterograde and retrograde transport. Here we show that activity stimulates further synaptic capture that is distinguished from basal capture by its selectivity for anterograde DCVs and its inhibition by overexpression of the fragile X retardation protein Fmr1. Fmr1 dramatically lowers DCV numbers in synaptic boutons. Therefore, activity-dependent anterograde capture is a major determinant of presynaptic peptide stores. Copyright © 2016 the authors 0270-6474/16/3611781-07$15.00/0.

An interval programming model for continuous improvement in micro-manufacturing

NASA Astrophysics Data System (ADS)

Ouyang, Linhan; Ma, Yizhong; Wang, Jianjun; Tu, Yiliu; Byun, Jai-Hyun

2018-03-01

Continuous quality improvement in micro-manufacturing processes relies on optimization strategies that relate an output performance to a set of machining parameters. However, when determining the optimal machining parameters in a micro-manufacturing process, the economics of continuous quality improvement and decision makers' preference information are typically neglected. This article proposes an economic continuous improvement strategy based on an interval programming model. The proposed strategy differs from previous studies in two ways. First, an interval programming model is proposed to measure the quality level, where decision makers' preference information is considered in order to determine the weight of location and dispersion effects. Second, the proposed strategy is a more flexible approach since it considers the trade-off between the quality level and the associated costs, and leaves engineers a larger decision space through adjusting the quality level. The proposed strategy is compared with its conventional counterparts using an Nd:YLF laser beam micro-drilling process.

Confidence intervals and sample size calculations for the standardized mean difference effect size between two normal populations under heteroscedasticity.

PubMed

Shieh, G

2013-12-01

The use of effect sizes and associated confidence intervals in all empirical research has been strongly emphasized by journal publication guidelines. To help advance theory and practice in the social sciences, this article describes an improved procedure for constructing confidence intervals of the standardized mean difference effect size between two independent normal populations with unknown and possibly unequal variances. The presented approach has advantages over the existing formula in both theoretical justification and computational simplicity. In addition, simulation results show that the suggested one- and two-sided confidence intervals are more accurate in achieving the nominal coverage probability. The proposed estimation method provides a feasible alternative to the most commonly used measure of Cohen's d and the corresponding interval procedure when the assumption of homogeneous variances is not tenable. To further improve the potential applicability of the suggested methodology, the sample size procedures for precise interval estimation of the standardized mean difference are also delineated. The desired precision of a confidence interval is assessed with respect to the control of expected width and to the assurance probability of interval width within a designated value. Supplementary computer programs are developed to aid in the usefulness and implementation of the introduced techniques.

Effects of High-Intensity Interval Training on Aerobic Capacity in Cardiac Patients: A Systematic Review with Meta-Analysis

PubMed Central

Xie, Bin; Yan, Xianfeng

2017-01-01

Purpose. The aim of this study was to compare the effects of high-intensity interval training (INTERVAL) and moderate-intensity continuous training (CONTINUOUS) on aerobic capacity in cardiac patients. Methods. A meta-analysis identified by searching the PubMed, Cochrane Library, EMBASE, and Web of Science databases from inception through December 2016 compared the effects of INTERVAL and CONTINUOUS among cardiac patients. Results. Twenty-one studies involving 736 participants with cardiac diseases were included. Compared with CONTINUOUS, INTERVAL was associated with greater improvement in peak VO2 (mean difference 1.76 mL/kg/min, 95% confidence interval 1.06 to 2.46 mL/kg/min, p < 0.001) and VO2 at AT (mean difference 0.90 mL/kg/min, 95% confidence interval 0.0 to 1.72 mL/kg/min, p = 0.03). No significant difference between the INTERVAL and CONTINUOUS groups was observed in terms of peak heart rate, peak minute ventilation, VE/VCO2 slope and respiratory exchange ratio, body mass, systolic or diastolic blood pressure, triglyceride or low- or high-density lipoprotein cholesterol level, flow-mediated dilation, or left ventricular ejection fraction. Conclusions. This study showed that INTERVAL improves aerobic capacity more effectively than does CONTINUOUS in cardiac patients. Further studies with larger samples are needed to confirm our observations. PMID:28386556

Reduced short interval cortical inhibition correlates with atomoxetine response in children with attention-deficit hyperactivity disorder (ADHD).

PubMed

Chen, Tina H; Wu, Steve W; Welge, Jeffrey A; Dixon, Stephan G; Shahana, Nasrin; Huddleston, David A; Sarvis, Adam R; Sallee, Floyd R; Gilbert, Donald L

2014-12-01

Clinical trials in children with attention-deficit hyperactivity disorder (ADHD) show variability in behavioral responses to the selective norepinephrine reuptake inhibitor atomoxetine. The objective of this study was to determine whether transcranial magnetic stimulation-evoked short interval cortical inhibition might be a biomarker predicting, or correlating with, clinical atomoxetine response. At baseline and after 4 weeks of atomoxetine treatment in 7- to 12-year-old children with ADHD, transcranial magnetic stimulation short interval cortical inhibition was measured, blinded to clinical improvement. Primary analysis was by multivariate analysis of covariance. Baseline short interval cortical inhibition did not predict clinical responses. However, paradoxically, after 4 weeks of atomoxetine, mean short interval cortical inhibition was reduced 31.9% in responders and increased 6.1% in nonresponders (analysis of covariance t 41 = 2.88; P = .0063). Percentage reductions in short interval cortical inhibition correlated with reductions in the ADHD Rating Scale (r = 0.50; P = .0005). In children ages 7 to 12 years with ADHD treated with atomoxetine, improvements in clinical symptoms are correlated with reductions in motor cortex short interval cortical inhibition. © The Author(s) 2014.

Effects of High Intensity Interval Training on Increasing Explosive Power, Speed, and Agility

NASA Astrophysics Data System (ADS)

Fajrin, F.; Kusnanik, N. W.; Wijono

2018-01-01

High Intensity Interval Training (HIIT) is a type of exercise that combines high-intensity exercise and low intensity exercise in a certain time interval. This type of training is very effective and efficient to improve the physical components. The process of improving athletes achievement related to how the process of improving the physical components, so the selection of a good practice method will be very helpful. This study aims to analyze how is the effects of HIIT on increasing explosive power, speed, and agility. This type of research is quantitative with quasi-experimental methods. The design of this study used the Matching-Only Design, with data analysis using the t-test (paired sample t-test). After being given the treatment for six weeks, the results showed there are significant increasing in explosive power, speed, and agility. HIIT in this study used a form of exercise plyometric as high-intensity exercise and jogging as mild or moderate intensity exercise. Increase was due to the improvement of neuromuscular characteristics that affect the increase in muscle strength and performance. From the data analysis, researchers concluded that, Exercises of High Intensity Interval Training significantly effect on the increase in Power Limbs, speed, and agility.

Dye laser amplifier including an improved window configuration for its dye beam

DOEpatents

O'Neil, R.W.; Davin, J.M.

1992-12-01

A dye laser amplifier in which a continuously replenished supply of dye is excited with a first light beam in order to amplify the intensity of a second different light beam passing therethrough is disclosed herein. This amplifier includes a cell though which a continuous stream of the dye is caused to pass, and means for directing the first beam into the cell while the second beam is directed into and through the same cell. There is also disclosed herein a specific improvement to this amplifier which resides in the use of a pair of particularly configured windows through which the second beam passes along fixed paths as the second beam enters and exits the dye cell. Each of these windows has a relatively thick main section which is substantially larger in dimensions transverse to its beam path than the cross section of the second beam itself, whereby to add structural integrity to the overall window. At the same time, the latter includes a second section which is disposed entirely within the confines of the main section and through which the second beam is intended to pass in its entirety. This second section is made substantially thinner than the main section in order to reduce optical distortion as the second beam passes therethrough. 4 figs.

Dye laser amplifier including an improved window configuration for its dye beam

DOEpatents

O'Neil, Richard W.; Davin, James M.

1992-01-01

A dye laser amplifier in which a continuously replenished supply of dye is excited with a first light beam in order to amplify the intensity of a second different light beam passing therethrough is disclosed herein. This amplifier includes a cell though which a continuous stream of the dye is caused to pass, and means for directing the first beam into the cell while the second beam is directed into and through the same cell. There is also disclosed herein a specific improvement to this amplifier which resides in the use of a pair of particularly configured windows through which the second beam passes along fixed paths as the second beam enters and exits the dye cell. Each of these windows has a relatively thick main section which is substantially larger in dimensions transverse to its beam path than the cross section of the second beam itself, whereby to add structural integrity to the overall window. At the same time, the latter includes a second section which is disposed entirely within the confines of the main section and through which the second beam is intended to pass in its entirety. This second section is made substantially thinner than the main section in order to reduce optical distortion as the second beam passes therethrough.

Patient satisfaction with extended-interval warfarin monitoring.

PubMed

Carris, Nicholas W; Hwang, Andrew Y; Smith, Steven M; Taylor, James R; Sando, Karen; Powell, Jason; Rosenberg, Eric I; Zumberg, Marc S; Gums, John G; Dietrich, Eric A; Anderson, Katherine Vogel

2016-11-01

Extended-interval monitoring of warfarin has been proposed to reduce follow-up burden and improve patient satisfaction. We aimed to make an initial assessment of anticoagulation satisfaction before and after an extended-interval warfarin monitoring intervention. We conducted a translational prospective single-arm pilot study of extended-interval warfarin monitoring in five pharmacist-managed anticoagulation clinics. Patients meeting CHEST guideline criteria for extended-interval warfarin monitoring began progressive extended-interval follow-up (6, 8, and 12 weeks thereafter). The Duke Anticoagulation Satisfaction Scale (DASS) was administered at baseline and at end-of-study or study removal (in patients no longer appropriate for extended interval follow-up). Forty-six patients had evaluable pre- and post-intervention DASS survey data. Mean age of patients was 66.5 years, 74 % were non-Hispanic whites, and 48 % were men. Patients completed a mean ± SD of 34 ± 22 weeks of follow-up. Mean ± SD total DASS score at baseline was 45.2 ± 14.2 versus 49.1 ± 14.9 at end-of-study (mean change, +3.9 [95 % CI -0.6-8.4; p = 0.09]), indicating no benefit-and trending toward decrement-to anticoagulation satisfaction. Change in anticoagulation satisfaction varied substantially following extended-interval monitoring, with no evidence of improved satisfaction. Plausible reasons for patients not preferring extended-interval monitoring include increased anxiety and disengagement from self-management activities, both potentially related to less frequent feedback and reassurance during extended interval-monitoring. Additional research is needed to identify who is likely to benefit most from extended-interval monitoring. Anticoagulation satisfaction should be considered with clinical factors and shared-decision making when implementing extended-interval warfarin monitoring.

Musical training generalises across modalities and reveals efficient and adaptive mechanisms for reproducing temporal intervals.

PubMed

Aagten-Murphy, David; Cappagli, Giulia; Burr, David

2014-03-01

Expert musicians are able to time their actions accurately and consistently during a musical performance. We investigated how musical expertise influences the ability to reproduce auditory intervals and how this generalises across different techniques and sensory modalities. We first compared various reproduction strategies and interval length, to examine the effects in general and to optimise experimental conditions for testing the effect of music, and found that the effects were robust and consistent across different paradigms. Focussing on a 'ready-set-go' paradigm subjects reproduced time intervals drawn from distributions varying in total length (176, 352 or 704 ms) or in the number of discrete intervals within the total length (3, 5, 11 or 21 discrete intervals). Overall, Musicians performed more veridical than Non-Musicians, and all subjects reproduced auditory-defined intervals more accurately than visually-defined intervals. However, Non-Musicians, particularly with visual stimuli, consistently exhibited a substantial and systematic regression towards the mean interval. When subjects judged intervals from distributions of longer total length they tended to regress more towards the mean, while the ability to discriminate between discrete intervals within the distribution had little influence on subject error. These results are consistent with a Bayesian model that minimizes reproduction errors by incorporating a central tendency prior weighted by the subject's own temporal precision relative to the current distribution of intervals. Finally a strong correlation was observed between all durations of formal musical training and total reproduction errors in both modalities (accounting for 30% of the variance). Taken together these results demonstrate that formal musical training improves temporal reproduction, and that this improvement transfers from audition to vision. They further demonstrate the flexibility of sensorimotor mechanisms in adapting to different task conditions to minimise temporal estimation errors. © 2013.

Modified Confidence Intervals for the Mean of an Autoregressive Process.

DTIC Science & Technology

1985-08-01

Validity of the method 45 3.6 Theorem 47 4 Derivation of corrections 48 Introduction 48 The zero order pivot 50 4.1 Algorithm 50 CONTENTS The first...of standard confidence intervals. There are several standard methods of setting confidence intervals in simulations, including the regener- ative... method , batch means, and time series methods . We-will focus-s on improved confidence intervals for the mean of an autoregressive process, and as such our

High-intensity interval training for improving postprandial hyperglycemia.

PubMed

Little, Jonathan P; Francois, Monique E

2014-12-01

High-intensity interval training (HIIT) has garnered attention in recent years as a time-efficient exercise option for improving cardiovascular and metabolic health. New research demonstrates that HIIT may be particularly effective for improving postprandial hyperglycemia in individuals with, or at risk for, type 2 diabetes (T2D). These findings have clinical relevance because elevated postprandial hyperglycemia is a significant risk factor for cardiovascular morbidity and mortality. This article summarizes the latest evidence demonstrating that HIIT can improve postprandial glucose control to highlight the potential application of HIIT in the prevention and management of T2D and associated cardiovascular complications.

Stroke preparedness in children: translating knowledge into behavioral intent: a systematic review and meta-analysis.

PubMed

Ottawa, Cassandra; Sposato, Luciano A; Nabbouh, Fadl; Saposnik, Gustavo

2015-10-01

If translated into behavioral intent, improving stroke knowledge may potentially impact on better outcomes. Children are an attractive target population since they can drive familial behavioral changes. However, the impact of interventions on stroke knowledge among children is unclear. We performed a systematic review and meta-analysis to investigate whether educational interventions targeting children improve stroke knowledge and lead to behavioral changes. We searched Ovid, PubMed, and Embase between January 2000 and December 2014. We included studies written in English reporting the number of children aged 6-15 years undergoing educational interventions on stroke and providing the results for baseline and early and late postintervention tests. We compared the proportion of correct answers between baseline, early, and late responses for two endpoints: knowledge and behavioral intent. Of the initial 58 articles found, we included nine that met the inclusion criteria. Compared with baseline tests (51·7%, 95% confidence interval 40·9-62·4), there was improvement in stroke knowledge in early (74·0%, 95% confidence interval 64·4-82·5, P = 0·002) and late (67·3%, 95% confidence interval 55·4-78·2, P = 0·027) responses. There was improvement in the early (92·1%, 95% confidence interval 86·0-96·6, P < 0·001) and late (83·9%, 95% confidence interval 73·5-92·1, P = 0·001) responses for behavioral intent compared with the baseline assessment (63·8%, 95% confidence interval 53·5-73·4). Children are a potentially attractive target population for improvement in stroke knowledge and behavioral intent, both in the short and long term. Our findings may support the implementation of large-scale stroke educational initiatives targeting children. © 2015 World Stroke Organization.

[III Catalan registry of ST elevation acute myocardial infarction. Comparison with former Catalan registries I and II from Catalonia, Spain].

PubMed

Figueras, Jaume; Heras, Magda; Baigorri, Francisco; Elosua, Roberto; Ferreira, Ignacio; Santaló, Miquel

2009-11-14

To analyze the use of reperfusion therapy in patients with ST elevation myocardial infarction (STEMI) in Catalonia in a registry performed in 2006 (IAM CAT III) and its comparison with 2 previous registries Frequency of reperfusion therapy and time intervals between symptom onset - reperfusion therapy were the principal variables investigated. The IAM CAT I (June-December 2000) included 1,450 patients, the IAM CAT II (October 2002-April 2003) 1,386, and the IAM CAT III (October-December 2006) 367. The proportion of patients treated with reperfusion increased progressively (72%, 79% and 81%) as the use of primary angioplasty (5%, 10% and 33%). In the III registry the transfer system most frequently used was the SEM/061 (17%, 32% and 47%, respectively) but the time interval symptom onset-first contact with the medical system did not improve (II, 90 vs III, 105 min), the interval symptom onset-thrombolytic therapy did hardly change (178, 165 and 177 min) and the interval hospital arrival-trombolysis (needle-door) tended to improve (59, 42 and 42 min). Thirty day mortality in STEMI patients declined progressively through the 3 registries (12.1, 10.6 and 7.4%, p=0.012). The proportion of STEMI patients treated with reperfusion has improved but the interval to its application has not been shortened. To improve the latter it is mandatory an earlier contact with the medical system, a shortening of the intervals door-needle and door-balloon through better coordination between the 061, the sanitary personnel and the hospital administration, and to consider the subject as a real sanitary priority.

Optimal debulking targets in women with advanced stage ovarian cancer: a retrospective study of immediate versus interval debulking surgery.

PubMed

Altman, Alon D; Nelson, Gregg; Chu, Pamela; Nation, Jill; Ghatage, Prafull

2012-06-01

The objective of this study was to examine both overall and disease-free survival of patients with advanced stage ovarian cancer after immediate or interval debulking surgery based on residual disease. We performed a retrospective chart review at the Tom Baker Cancer Centre in Calgary, Alberta of patients with pathologically confirmed stage III or IV ovarian cancer, fallopian tube cancer, or primary peritoneal cancer between 2003 and 2007. We collected data on the dates of diagnosis, recurrence, and death; cancer stage and grade, patients' age, surgery performed, and residual disease. One hundred ninety-two patients were included in the final analysis. The optimal debulking rate with immediate surgery was 64.8%, and with interval surgery it was 85.9%. There were improved overall and disease-free survival rates for optimally debulked disease (< 1 cm) with both immediate and interval surgery (P < 0.001) compared to suboptimally debulked disease. Overall survival rates for optimally debulked disease were not significantly different in patients having immediate and interval surgery (P = 0.25). In the immediate surgery group, patients with microscopic residual disease had better disease-free survival (P = 0.015) and overall survival (P = 0.005) than patients with < 1 cm residual disease. In patients who had interval surgery, those who had microscopic residual disease had more improved disease-free survival than those with < 1 cm disease (P = 0.05), but they did not have more improved overall survival (P = 0.42). Patients with microscopic residual disease who had immediate surgery had a significantly better overall survival rate than those who had interval surgery (P = 0.034). In women with advanced stage ovarian cancer, the goal of surgery should be resection of disease to microscopic residual at the initial procedure. This results in improved overall survival than lesser degrees of resection. Further studies are required to determine optimal surgical management.

Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson's Disease.

PubMed

Pandareesh, M D; Shrivash, M K; Naveen Kumar, H N; Misra, K; Srinivas Bharath, M M

2016-11-01

Curcumin (CUR), a dietary polyphenol has diverse pharmacologic effects, but is limited by poor bioavailability. This is probably due to decreased solubility, cellular uptake and stability. In order to enhance its solubility and bioavailability, we synthesized the CUR bioconjugate curcumin monoglucoside (CMG) and tested its bioavailability, neuroprotective and anti-apoptotic propensity against rotenone (ROT) induced toxicity in N27 dopaminergic neuronal cells and Drosophila models. Our results elucidate that CMG showed improved bioavailability than CUR in N27 cells. Pre-treatment with CMG protected against ROT neurotoxicity and exerted antioxidant effects by replenishing cellular glutathione levels and significantly decreasing reactive species. CMG pre-treatment also restored mitochondrial complex I and IV activities inhibited by ROT. ROT-induced nuclear damage was also restored by CMG as confirmed by comet assay. CMG induced anti-apoptotic effects was substantiated by decreased phosporylation of JNK3 and c-jun, which in turn decreased the cleavage of pro-caspase 3. Q-PCR analysis of redox genes showed up-regulation of NOS2 and down-regulation of NQO1 upon ROT exposure and this was attenuated by CMG pre-treatment. Studies in the Drosophila ROT model revealed that, CMG administration showed better survival rate and locomotor activity, improved antioxidant activity and dopamine content than ROT treated group and was comparable with the CUR group. Based on these data, we surmise that CMG has improved bioavailability and offered neuroprotection comparable with CUR, against ROT-induced toxicity both in dopaminergic neuronal cell line and Drosophila models, with therapeutic implications for PD.

Influences of seasons, N/P ratios and chemical compounds on phosphorus removal performance in algal pond combined with constructed wetlands.

PubMed

Zhimiao, Zhao; Xinshan, Song; Yanping, Xiao; Yufeng, Zhao; Zhijie, Gong; Fanda, Lin; Yi, Ding; Wei, Wang; Tianling, Qin

2016-12-15

Nitrogen (N) and phosphorous (P) are main contaminants and P removal was restrained by several factors: season, N/P, and chemical compounds (CCs) in water ecosystems. In this paper, two algal ponds combined with constructed wetlands were built to increase the removal performance. Different hydraulic retention time (HRT), different N/P and chemical compounds were chosen to investigate the influences of the above factors on the contaminant removal performance. The optimum phosphorus removal rate was 69.74% under the nitrogen removal of 92.85% in influent containing PO 4 3- after 3-day HRT in algal pond combined with constructed wetlands. The investigation results indicated that these factors improved the nutrient removal efficiencies. Seasonal influence on the removal performance can be avoided by choosing the optimal HRT length of 3days. The higher N/P at 60 can improve the phosphorus removal and the lower N/P at 15 showed the stronger synergistic effect between phosphorus and nitrogen removals. Compared with PO 3 - and P 2 O 7 4- in influent, PO 4 3- affected phosphorus removal more significantly. The better linear fitting between organic phosphorus removal and nitrogen removal in influent contained P 2 O 7 4- was found. Algae can absorb nutrients for growth, and oxygen release, microbial activity intensification and microbial carbon replenishment induced by algae will improve the performance. The study suggested that the control of HRTs, N/Ps, CCs, and algae might be an effective way to improve wastewater treatment performance. Copyright © 2016 Elsevier B.V. All rights reserved.

Improving the performance of enzymes in hydrolysis of high solids paper pulp derived from MSW.

PubMed

Puri, Dhivya J; Heaven, Sonia; Banks, Charles J

2013-01-01

The research aimed to improve the overall conversion efficiency of the CTec® family of enzymes by identifying factors that lead to inhibition and seeking methods to overcome these through process modification and manipulation. The starting material was pulp derived from municipal solid waste and processed in an industrial-scale washing plant. Analysis of the pulp by acid hydrolysis showed a ratio of 55 : 12 : 6 : 24 : 3 of glucan : xylan : araban/galactan/mannan : lignin : ash. At high total solids content (>18.5% TS) single-stage enzyme hydrolysis gave a maximum glucan conversion of 68%. It was found that two-stage hydrolysis could give higher conversion if sugar inhibition was removed by an intermediate fermentation step between hydrolysis stages. This, however, was not as effective as direct removal of the sugar products, including xylose, by washing of the residual pulp at pH 5. This improved the water availability and allowed reactivation of the pulp-bound enzymes. Inhibition of enzyme activity could further be alleviated by replenishment of β-glucosidase which was shown to be removed during the wash step. The two-stage hydrolysis process developed could give an overall glucan conversion of 88%, with an average glucose concentration close to 8% in 4 days, thus providing an ideal starting point for ethanol fermentation with a likely yield of 4 wt%. This is a significant improvement over a single-step process. This hydrolysis configuration also provides the potential to recover the sugars associated with residual solids which are diluted when washing hydrolysed pulp.

Short-term low-intensity blood flow restricted interval training improves both aerobic fitness and muscle strength.

PubMed

de Oliveira, M F M; Caputo, F; Corvino, R B; Denadai, B S

2016-09-01

The present study aimed to analyze and compare the effects of four different interval-training protocols on aerobic fitness and muscle strength. Thirty-seven subjects (23.8 ± 4 years; 171.7 ± 9.5 cm; 70 ± 11 kg) were assigned to one of four groups: low-intensity interval training with (BFR, n = 10) or without (LOW, n = 7) blood flow restriction, high-intensity interval training (HIT, n = 10), and combined HIT and BFR (BFR + HIT, n = 10, every session performed 50% as BFR and 50% as HIT). Before and after 4 weeks training (3 days a week), the maximal oxygen uptake (VO2max ), maximal power output (Pmax ), onset blood lactate accumulation (OBLA), and muscle strength were measured for all subjects. All training groups were able to improve OBLA (BFR, 16%; HIT, 25%; HIT + BFR, 22%; LOW, 6%), with no difference between groups. However, VO2max and Pmax improved only for BFR (6%, 12%), HIT (9%, 15%) and HIT + BFR (6%, 11%), with no difference between groups. Muscle strength gains were only observed after BFR training (11%). This study demonstrates the advantage of short-term low-intensity interval BFR training as the single mode of training able to simultaneously improve aerobic fitness and muscular strength. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

History of the Coastal Engineering Research Center 1963-1983, Volume 1

DTIC Science & Technology

1991-01-01

jn the groin and sand replenishment projects at Newport Beach, California; Presque Isle Peninsu la on Lake Erie at Erie , Pennsyl - varua; and...of Environmental Resources in dune building field tests at Ludington State Park, Michigan, and Presque Isle State Park. Pennsylvania . After the...Shelf." 3 . Dennis W. Berg ... J- actor’> Affecting Beach Nourishmem Requirements. Presque Isle Peninsula, Erie , Pennsy lvania,’’ Great Lakes

Repair, Evaluation, Maintenance, and Rehabilitation Research Program. Inspection of the Engineering Condition of Underwater Concrete Structures.

DTIC Science & Technology

1989-04-01

corrosion of rebar Spalling of concrete surface IIl Detect hidden and beginning Location of rebar damage Beginning corrosion of rebar ...honeycombs MD Moderate defects: spalling of concrete minor corrosion of exposed rebar rust stains along rebar with or without visible cracking softening of...velocity. . Replenishment of the attacking chemical hgents. h. Higher temperatures. i. Corrosion of reinforcing steel. 46. Note that concrete which

Hybrid Oxygen System

DTIC Science & Technology

1992-10-01

8 6 Summary Specs--Backup/Peak Shaving Mission Scenarios ..... 10 7 Boil-Off Replenishment (1 2-hr missions...11 8 Hybrid Oxygen Component Sizing ................................. 23 9 Mass Fraction Concentration of Condensibles..................... 25 10 ...lOIb 4" 11" 75% 18 B. 100 watt $350,000 20 wks 10 lb 100 C. 370 watt $500,000 24 wks 10 lb 370 Sulzer Bros. Turboexpander TGL-22-11/B2 $80,000 8 mos 90

21st International Seapower Symposium

DTIC Science & Technology

2015-02-01

frequency ] radio on channel ten. • AV17-8 T2000: I intend to conduct vertical replenishment operations at 2000. • X Corpen Port 000: I intend to alter...welcome you to Newport, Rhode Island, for the 21st International Seapower Symposium (ISS-21). The International Naval Community is well-represented...Italy .......................... 173 Chapter 11 Closing Remarks Rear Admiral P. Gardener Howe III and Admiral Jonathan W. Greenert, U.S. Navy

A Gap Analysis of Life Cycle Management Commands and Best Purchasing and Supply Management Organizations

DTIC Science & Technology

2013-01-01

of the Army’s Life Cycle Management Commands (LCMCs)—those for Aviation and Missiles (AMCOM), Communications - Electronics (CECOM), and Tank-automotive...took time from their busy schedules to participate in our interviews. We would like to thank Lieutenant Colonel John Coombs for helping us track down...Army Communications -Electronics Life Cycle Management Command CPFR collaborative planning, forecasting, and replenishment DCMA Defense Contract

A Baseline Analysis of Combat Logistics Force Scheduling Efficiency

DTIC Science & Technology

2016-06-01

from the data were mostly inconclusive, however; as a result, this paper recommends expanding the research years for further data analysis to include...the warship in the Fifth Fleet area of responsibility. The trends from the data were mostly inconclusive, however; as a result, this paper recommends...Commander, Naval Surface Forces T-AKE dry cargo ammunition ship T-AO fleet replenishment oiler T-AOE fast combat support ship THRSG Theodore

A Comparison of Sleep and Performance of Sailors on an Operationally Deployed U.S. Navy Warship

DTIC Science & Technology

2013-09-01

The crew’s mission on a deployed warship is inherently dangerous. The nature of the job means navigating restricted waters, conducting underway...The nature of the job means navigating restricted waters, conducting underway replenishments with less than 200 feet of lateral separation from... concentration equivalent. Error bars ± s.e. (From Dawson & Reid, 1997). .............................9 Figure 4. Mean psychomotor vigilance task speed (and

Automatic Control of Silicon Melt Level

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Stickel, W. B.

1982-01-01

A new circuit, when combined with melt-replenishment system and melt level sensor, offers continuous closed-loop automatic control of melt-level during web growth. Installed on silicon-web furnace, circuit controls melt-level to within 0.1 mm for as long as 8 hours. Circuit affords greater area growth rate and higher web quality, automatic melt-level control also allows semiautomatic growth of web over long periods which can greatly reduce costs.

Little Fish in a Big Pond--Time to Get Schooled!

ERIC Educational Resources Information Center

Moye, Johnny J.

2011-01-01

One technique used by many who fish is to catch a fish in a creek or pond and then release it in a different pond. This satisfies the desire for sport, and it also serves to stock a pond that may need replenishment. Of course this restocking can be a traumatic experience for the new fish. To survive in the new environment, the fish must find its…