A High-Granularity Approach to Modeling Energy Consumption and Savings Potential in the U.S. Residential Building Stock

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Building simulations are increasingly used in various applications related to energy efficient buildings. For individual buildings, applications include: design of new buildings, prediction of retrofit savings, ratings, performance path code compliance and qualification for incentives. Beyond individual building applications, larger scale applications (across the stock of buildings at various scales: national, regional and state) include: codes and standards development, utility program design, regional/state planning, and technology assessments. For these sorts of applications, a set of representative buildings are typically simulated to predict performance of the entire population of buildings. Focusing on the U.S. single-family residential building stock, this paper willmore » describe how multiple data sources for building characteristics are combined into a highly-granular database that preserves the important interdependencies of the characteristics. We will present the sampling technique used to generate a representative set of thousands (up to hundreds of thousands) of building models. We will also present results of detailed calibrations against building stock consumption data.« less

Mathematical Storage-Battery Models

NASA Technical Reports Server (NTRS)

Chapman, C. P.; Aston, M.

1985-01-01

Empirical formula represents performance of electrical storage batteries. Formula covers many battery types and includes numerous coefficients adjusted to fit peculiarities of each type. Battery and load parameters taken into account include power density in battery, discharge time, and electrolyte temperature. Applications include electric-vehicle "fuel" gages and powerline load leveling.

49 CFR 260.31 - Execution and filing of the application.

Code of Federal Regulations, 2010 CFR

2010-10-01

...; that he or she has examined the financial statements and supporting schedules included in this... attached to such statements, those financial statements and supporting schedules represent a true and complete statement of the financial position of the Applicant and that there are no undisclosed assets...

Mobile Technology for the Practice of Pathology.

PubMed

Hartman, Douglas J

2016-03-01

Recently, several technological advances have been introduced to mobile phones leading some people to refer to them as "smartphones." These changes have led to widespread consumer adoption. A similar adoption has occurred within the medical field and this revolution is changing the practice of medicine, including pathology. Several mobile applications have been published for dermatology, orthopedics, ophthalmology, neurosurgery, and clinical pathology. The applications are wide ranging, including mobile technology to increase patient engagement, self-monitoring by patients, clinical algorithm calculation, facilitation between experts to resource-poor environments. These advances have been received with mixed reviews. For anatomic pathology, mobile technology applications can be broken into 4 broad categories: (a) educational uses, (b) microscope with mobile phone, (c) mobile phone as microscope/acquisition device, and (d) miscellaneous. Using a mobile phone as an acquisition device paired with a microscope seems to be the most interesting current application because of the need for expert consultation with resource-poor environments. However, several emerging uses for mobile technology may become more prominent as the technology matures including image analysis, alternative light sources, and increased opportunities for clinician and patient engagement. The flexibility represented by mobile technology represents a burgeoning field in pathology informatics.

Systems configured to distribute a telephone call, communication systems, communication methods and methods of routing a telephone call to a service representative

DOEpatents

Harris, Scott H.; Johnson, Joel A.; Neiswanger, Jeffery R.; Twitchell, Kevin E.

2004-03-09

The present invention includes systems configured to distribute a telephone call, communication systems, communication methods and methods of routing a telephone call to a customer service representative. In one embodiment of the invention, a system configured to distribute a telephone call within a network includes a distributor adapted to connect with a telephone system, the distributor being configured to connect a telephone call using the telephone system and output the telephone call and associated data of the telephone call; and a plurality of customer service representative terminals connected with the distributor and a selected customer service representative terminal being configured to receive the telephone call and the associated data, the distributor and the selected customer service representative terminal being configured to synchronize, application of the telephone call and associated data from the distributor to the selected customer service representative terminal.

Further Applications of Linguistics to Australian Aboriginal Contexts. Occasional Papers Number 8.

ERIC Educational Resources Information Center

McKay, G. R., Ed.; Sommer, B. A., Ed.

These papers represent applications of linguistics in Australian Aboriginal contexts, not only from a language viewpoint, but encompassing the interactions of language, society, politics, and culture. They include: "Loanwords: Ours or Theirs?" (Velma J. Leeding); "We Spell It 'Gooniyandi'" (David Street and Topsy Chestnut);…

76 FR 27020 - Representative and Address Provisions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... information about the application using the Patent Application Information Retrieval (PAIR) system, which is... information collection, as required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506... submit comments by any of the following methods: E-mail: Information[email protected] . Include ``0651...

40 CFR 74.43 - Annual compliance certification report.

Code of Federal Regulations, 2010 CFR

2010-07-01

... which an opt-in source is subject to the Acid Rain emissions limitations, the designated representative... compliance with the requirements of the Acid Rain Program applicable to the opt-in source, including: (1) Whether the opt-in source was operated in compliance with applicable Acid Rain emissions limitations...

40 CFR 74.43 - Annual compliance certification report.

Code of Federal Regulations, 2014 CFR

2014-07-01

... which an opt-in source is subject to the Acid Rain emissions limitations, the designated representative... compliance with the requirements of the Acid Rain Program applicable to the opt-in source, including: (1) Whether the opt-in source was operated in compliance with applicable Acid Rain emissions limitations...

40 CFR 74.43 - Annual compliance certification report.

Code of Federal Regulations, 2011 CFR

2011-07-01

... which an opt-in source is subject to the Acid Rain emissions limitations, the designated representative... compliance with the requirements of the Acid Rain Program applicable to the opt-in source, including: (1) Whether the opt-in source was operated in compliance with applicable Acid Rain emissions limitations...

40 CFR 74.43 - Annual compliance certification report.

Code of Federal Regulations, 2013 CFR

2013-07-01

... which an opt-in source is subject to the Acid Rain emissions limitations, the designated representative... compliance with the requirements of the Acid Rain Program applicable to the opt-in source, including: (1) Whether the opt-in source was operated in compliance with applicable Acid Rain emissions limitations...

40 CFR 74.43 - Annual compliance certification report.

Code of Federal Regulations, 2012 CFR

2012-07-01

... which an opt-in source is subject to the Acid Rain emissions limitations, the designated representative... compliance with the requirements of the Acid Rain Program applicable to the opt-in source, including: (1) Whether the opt-in source was operated in compliance with applicable Acid Rain emissions limitations...

Active-Twist Rotor Control Applications for UAVs

NASA Technical Reports Server (NTRS)

Wilbur, Matthew L.; Wilkie, W. Keats

2004-01-01

The current state-of-the-art in active-twist rotor control is discussed using representative examples from analytical and experimental studies, and the application to rotary-wing UAVs is considered. Topics include vibration and noise reduction, rotor performance improvement, active blade tracking, stability augmentation, and rotor blade de-icing. A review of the current status of piezoelectric fiber composite actuator technology, the class of piezoelectric actuators implemented in active-twist rotor systems, is included.

25 CFR 1000.66 - What must be included in the application?

Code of Federal Regulations, 2010 CFR

2010-04-01

... EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs... planning and negotiation grant must include: (a) Written notification by the governing body or its authorized representative of the Tribe's/Consortium's intent to engage in planning/negotiation activities...

40 CFR 86.094-22 - Approval of application for certification; test fleet selections; determinations of parameters...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Where any part of an application is rejected, the Administrator shall notify the manufacturer in writing... writing, signed by an authorized representative of the manufacturer and shall include a statement... information from similar in-use vehicles (or engines), the difficulty and cost of gaining access to an...

Principal Component Analysis: Resources for an Essential Application of Linear Algebra

ERIC Educational Resources Information Center

Pankavich, Stephen; Swanson, Rebecca

2015-01-01

Principal Component Analysis (PCA) is a highly useful topic within an introductory Linear Algebra course, especially since it can be used to incorporate a number of applied projects. This method represents an essential application and extension of the Spectral Theorem and is commonly used within a variety of fields, including statistics,…

50 CFR 679.42 - Limitations on use of QS and IFQ.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., Juneau, AK 99802-1668. A complete application must include: (A) The applicant's (transferor's) identity... community of Adak, AK, individually or collectively, may use more than 3,229,721 units of sablefish QS... of Adak, AK, after March 17, 2019. (9) A CQE representing an eligible community in the Aleutian...

Common IED exploitation target set ontology

NASA Astrophysics Data System (ADS)

Russomanno, David J.; Qualls, Joseph; Wowczuk, Zenovy; Franken, Paul; Robinson, William

2010-04-01

The Common IED Exploitation Target Set (CIEDETS) ontology provides a comprehensive semantic data model for capturing knowledge about sensors, platforms, missions, environments, and other aspects of systems under test. The ontology also includes representative IEDs; modeled as explosives, camouflage, concealment objects, and other background objects, which comprise an overall threat scene. The ontology is represented using the Web Ontology Language and the SPARQL Protocol and RDF Query Language, which ensures portability of the acquired knowledge base across applications. The resulting knowledge base is a component of the CIEDETS application, which is intended to support the end user sensor test and evaluation community. CIEDETS associates a system under test to a subset of cataloged threats based on the probability that the system will detect the threat. The associations between systems under test, threats, and the detection probabilities are established based on a hybrid reasoning strategy, which applies a combination of heuristics and simplified modeling techniques. Besides supporting the CIEDETS application, which is focused on efficient and consistent system testing, the ontology can be leveraged in a myriad of other applications, including serving as a knowledge source for mission planning tools.

42 CFR 67.15 - Peer review of applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

...; (viii) The extent to which women and minorities are adequately represented in study populations; (ix... conference, specifically the importance of the issue or problem being addressed, including methodological or...

42 CFR 67.15 - Peer review of applications.

Code of Federal Regulations, 2012 CFR

2012-10-01

...; (viii) The extent to which women and minorities are adequately represented in study populations; (ix... conference, specifically the importance of the issue or problem being addressed, including methodological or...

42 CFR 67.15 - Peer review of applications.

Code of Federal Regulations, 2011 CFR

2011-10-01

...; (viii) The extent to which women and minorities are adequately represented in study populations; (ix... conference, specifically the importance of the issue or problem being addressed, including methodological or...

42 CFR 67.15 - Peer review of applications.

Code of Federal Regulations, 2014 CFR

2014-10-01

...; (viii) The extent to which women and minorities are adequately represented in study populations; (ix... conference, specifically the importance of the issue or problem being addressed, including methodological or...

42 CFR 67.15 - Peer review of applications.

Code of Federal Regulations, 2013 CFR

2013-10-01

...; (viii) The extent to which women and minorities are adequately represented in study populations; (ix... conference, specifically the importance of the issue or problem being addressed, including methodological or...

Program and Abstracts, Boron Americas IX Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feakes, Debra A.

The Scientific and Technical Information (STI) submitted includes the final report and a collection of abstracts for the Ninth Boron in the Americas Conference which was held May 19-22, 2004, in San Marcos, Texas. The topics covered in the abstracts include: Application in Medicine, Application in Organic Synthesis and Catalysis, Boranes and Carboranes, Materials and Polymers, Metallaboranes and Metallacarboranes, Organoboron Compounds, Synthesis and Catalysis, and Theoretical Studies. Attendees represented researchers from government, industry, and academia.

Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity.

PubMed

Alshehri, Reem; Ilyas, Asad Muhammad; Hasan, Anwarul; Arnaout, Adnan; Ahmed, Farid; Memic, Adnan

2016-09-22

Carbon nanotubes (CNTs) represent one of the most studied allotropes of carbon. The unique physicochemical properties of CNTs make them among prime candidates for numerous applications in biomedical fields including drug delivery, gene therapy, biosensors, and tissue engineering applications. However, toxicity of CNTs has been a major concern for their use in biomedical applications. In this review, we present an overview of carbon nanotubes in biomedical applications; we particularly focus on various factors and mechanisms affecting their toxicity. We have discussed various parameters including the size, length, agglomeration, and impurities of CNTs that may cause oxidative stress, which is often the main mechanism of CNTs' toxicity. Other toxic pathways are also examined, and possible ways to overcome these challenges have been discussed.

Assessment of radioisotope heaters for remote terrestrial applications

NASA Astrophysics Data System (ADS)

Uherka, Kenneth L.

This paper examines the feasibility of using radioisotope byproducts for special heating applications at remote sites in Alaska and other cold regions. The investigation included assessment of candidate radioisotope materials for heater applications, identification of the most promising cold-region applications, evaluation of key technical issues and implementation constraints, and development of conceptual heater designs for candidate applications. Strontium-90 (Sr-90) was selected as the most viable fuel for radioisotopic heaters used in terrestrial applications. Opportunities for the application of radioisotopic heaters were determined through site visits to representative Alaskan installations. Candidate heater applications included water storage tanks, sludge digesters, sewage lagoons, water piping systems, well-head pumping stations, emergency shelters, and fuel storage tank deicers. Radio-isotopic heaters for freeze-up protection of water storage tanks and for enhancement of biological waste treatment processes at remote sites were selected as the most promising applications.

Designing and Using Projects with Real World Application in a MBA Managerial Accounting Class: The Case of The Balanced Scorecard

ERIC Educational Resources Information Center

Houke, Charlotte

2017-01-01

This paper explores the purpose of designing and using projects with real world application in a M.B.A. managerial accounting class. Included is a discussion of how and why the Balanced Scorecard (BSC) Project has been used in classes to link theory with practice by providing real world application of the BSC framework. M.B.A. students represent a…

48 CFR 252.225-7046 - Exports by Approved Community Members in Response to the Solicitation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... all applicable International Traffic in Arms Regulations (ITAR) requirements, including any criminal.../Title of Duly Authorized RepresentativeDate (h) Subcontracts. The offeror shall flow down the substance...

Left Brain/Right Brain: Research and Learning. Focused Access to Selected Topics (FAST) Bibliography No. 12.

ERIC Educational Resources Information Center

Eppele, Ruth

This 27-item bibliography represents the variety of articles added to the ERIC database from 1983 through 1988 on left-brain/right-brain research, theory, and application as it relates to classroom incorporation. Included are conflicting opinions as to the usefulness of left-brain/right-brain studies and their application in the learning…

Representing Value as Digital Object: A Discussion of Transferability and Anonymity; Digital Library Initiatives of the Deutsche Forschungsgemeinschaft; CrossRef Turns One; Fermi National Accelerator Laboratory (Fermilab).

ERIC Educational Resources Information Center

Kahn, Robert E.; Lyons, Patrice A.; Brahms, Ewald; Brand, Amy; van den Bergen, Mieke

2001-01-01

Includes four articles that discuss the use of digital objects to represent value in a network environment; digital library initiatives at the central public funding organization for academic research in Germany; an application of the Digital Object Identifier System; and the Web site of the Fermi National Accelerator Laboratory. (LRW)

Correlation of Predicted and Flight Derived Stability and Control Derivatives with Particular Application to Tailless Delta Wing Configurations

NASA Technical Reports Server (NTRS)

Weil, J.

1981-01-01

Flight derived longitudinal and lateral-directional stability and control derivatives were compared to wind-tunnel derived values. As a result of these comparisons, boundaries representing the uncertainties that could be expected from wind-tunnel predictions were established. These boundaries provide a useful guide for control system sensitivity studies prior to flight. The primary application for this data was the space shuttle, and as a result the configurations included in the study were those most applicable to the space shuttle. The configurations included conventional delta wing aircraft as well as the X-15 and lifting body vehicles.

Multiphysics Simulations: Challenges and Opportunities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keyes, David; McInnes, Lois C.; Woodward, Carol

2013-02-12

We consider multiphysics applications from algorithmic and architectural perspectives, where ‘‘algorithmic’’ includes both mathematical analysis and computational complexity, and ‘‘architectural’’ includes both software and hardware environments. Many diverse multiphysics applications can be reduced, en route to their computational simulation, to a common algebraic coupling paradigm. Mathematical analysis of multiphysics coupling in this form is not always practical for realistic applications, but model problems representative of applications discussed herein can provide insight. A variety of software frameworks for multiphysics applications have been constructed and refined within disciplinary communities and executed on leading-edge computer systems. We examine several of these, expose somemore » commonalities among them, and attempt to extrapolate best practices to future systems. From our study, we summarize challenges and forecast opportunities.« less

The lone inventor: low success rates and common errors associated with pro-se patent applications.

PubMed

Gaudry, Kate S

2012-01-01

A pro-se patent applicant is an inventor who chooses to represent himself while pursuing ("prosecuting") a patent application. To the author's knowledge, this paper is the first empirical study addressing how applications filed by pro-se inventors fare compared to applications in which inventors were represented by patent attorneys or agents. The prosecution history of 500 patent applications filed at the United States Patent and Trademark Office were analyzed: inventors were represented by a patent professional for 250 of the applications ("represented applications") but not in the other 250 ("pro-se applications"). 76% of the pro-se applications became abandoned (not issuing as a patent), as compared to 35% of the represented applications. Further, among applications that issued as patents, pro-se patents' claims appear to be narrower and therefore of less value than claims in the represented patent set. Case-specific data suggests that a substantial portion of pro-se applicants unintentionally abandon their applications, terminate the examination process relatively early, and/or fail to take advantage of interview opportunities that may resolve issues stalling allowance of the application.

77 FR 25787 - Low Income Taxpayer Clinic Grant Program; Availability of 2013 Grant Application Package

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... a grant. Examples of qualifying organizations include: (1) A clinical program at an accredited law, business or accounting school whose students represent low income taxpayers in tax controversies with the...

Proceedings of the 4th Annual Workshop: Advances in Smart Materials for Aerospace Applications

NASA Technical Reports Server (NTRS)

Hardy, Robin C. (Editor); Simpson, Joycelyn O. (Editor)

1996-01-01

The objective of the Fourth Annual Conference on Advances in Smart Materials for Aerospace Applications was to provide a forum for technical dialogue on numerous topics in the area of smart materials. The proceedings presented herein represent the technical contributions of the participants of the workshop. Topics addressed include shape memory alloys, ferroelectrics, fiber optics, finite element simulation, and active control.

Knowledge Based System Applications for Guidance and Control (Application des Systemes a Base de Connaissances au Guidage-Pilotage)

DTIC Science & Technology

1991-01-01

techniques and integration concepts. Recent advances in digital computation techniques including data base management , represent the core enabling...tactical information management and effective pilot interaction are essential. Pilot decision aiding, combat automation, sensor fusion and ol-board...tactical battle management concepts offer the opportunity for substantial mission effectiveness improvements. Although real-time tactical military

Graphics Technology in Space Applications (GTSA 1989)

NASA Technical Reports Server (NTRS)

Griffin, Sandy (Editor)

1989-01-01

This document represents the proceedings of the Graphics Technology in Space Applications, which was held at NASA Lyndon B. Johnson Space Center on April 12 to 14, 1989 in Houston, Texas. The papers included in these proceedings were published in general as received from the authors with minimum modifications and editing. Information contained in the individual papers is not to be construed as being officially endorsed by NASA.

Risk analysis and timber investments: a bibliography of theory and applications.

Treesearch

Carol A. Hyldahl; David C. Baumgartner

1991-01-01

Contains a fairly complete set of references to the small but rapidly growing amount of literature directly related to the study of risk in forestry in the United States up to 1989. Also includes representative references for the huge literature of general financial theory dealing with risk. Includes 95 annotated references and 17 additional textbook references...

Undergraduates Who Do Not Apply for Financial Aid. Data Point. NCES 2016-406

ERIC Educational Resources Information Center

Ifill, Nicole

2016-01-01

This report is based on data from the 2011-12 National Postsecondary Student Aid Study (NPSAS:12), a large, nationally representative sample survey of students that focuses on how they finance their education. NPSAS includes data on the application for and receipt of financial aid, including grants, loans, assistantships, scholarships,…

76 FR 10209 - Corporate Credit Unions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... natural person credit unions (NPCUs) may wish to form new corporates. Previous corporate chartering... NCUA's standards for evaluating applications. It also included detailed timelines for processing... natural person representatives of natural person credit unions (NPCUs)--``the subscribers''--may charter a...

75 FR 15679 - Foreign-Trade Zone 272-Lehigh Valley, Pennsylvania Application for Subzone Grundfos Pumps...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

... from abroad (representing 65% of the value of the finished pumps) include: Pump parts, electric motors, plastic closures and o- rings, rubber o-rings and gaskets, labels, pipe fittings, fasteners, motor...

Quantum kernel applications in medicinal chemistry.

PubMed

Huang, Lulu; Massa, Lou

2012-07-01

Progress in the quantum mechanics of biological molecules is being driven by computational advances. The notion of quantum kernels can be introduced to simplify the formalism of quantum mechanics, making it especially suitable for parallel computation of very large biological molecules. The essential idea is to mathematically break large biological molecules into smaller kernels that are calculationally tractable, and then to represent the full molecule by a summation over the kernels. The accuracy of the kernel energy method (KEM) is shown by systematic application to a great variety of molecular types found in biology. These include peptides, proteins, DNA and RNA. Examples are given that explore the KEM across a variety of chemical models, and to the outer limits of energy accuracy and molecular size. KEM represents an advance in quantum biology applicable to problems in medicine and drug design.

Investigating implicit knowledge in ontologies with application to the anatomical domain.

PubMed

Zhang, S; Bodenreider, O

2004-01-01

Knowledge in biomedical ontologies can be explicitly represented (often by means of semantic relations), but may also be implicit, i.e., embedded in the concept names and inferable from various combinations of semantic relations. This paper investigates implicit knowledge in two ontologies of anatomy: the Foundational Model of Anatomy and GALEN. The methods consist of extracting the knowledge explicitly represented, acquiring the implicit knowledge through augmentation and inference techniques, and identifying the origin of each semantic relation. The number of relations (12 million in FMA and 4.6 million in GALEN), broken down by source, is presented. Major findings include: each technique provides specific relations; and many relations can be generated by more than one technique. The application of these findings to ontology auditing, validation, and maintenance is discussed, as well as the application to ontology integration.

Statistical fingerprinting for malware detection and classification

DOEpatents

Prowell, Stacy J.; Rathgeb, Christopher T.

2015-09-15

A system detects malware in a computing architecture with an unknown pedigree. The system includes a first computing device having a known pedigree and operating free of malware. The first computing device executes a series of instrumented functions that, when executed, provide a statistical baseline that is representative of the time it takes the software application to run on a computing device having a known pedigree. A second computing device executes a second series of instrumented functions that, when executed, provides an actual time that is representative of the time the known software application runs on the second computing device. The system detects malware when there is a difference in execution times between the first and the second computing devices.

Advanced Life Support Systems: Opportunities for Technology Transfer

NASA Technical Reports Server (NTRS)

Fields, B.; Henninger, D.; Ming, D.; Verostko, C. E.

1994-01-01

NASA's future missions to explore the solar system will be of long-duration possibly lasting years at a time. Human life support systems will have to operate with very high reliability for these long periods with essentially no resupply from Earth. Such life support systems will make extensive use of higher plants, microorganisms, and physicochemical processes for recycling air and water, processing wastes, and producing food. Development of regenerative life support systems will be a pivotal capability for NASA's future human missions. A fully functional closed loop human life support system currently does not exist and thus represents a major technical challenge for space exploration. Technologies where all life support consumables are recycled have many potential terrestrial applications as well. Potential applications include providing human habitation in hostile environments such as the polar regions or the desert in such a way as to minimize energy expenditures and to minimize negative impacts on those often ecologically-sensitive areas. Other potential applications include production of food and ornamental crops without damaging the environment from fertilizers that contaminate water supplies; removal of trace gas contaminants from tightly sealed, energy-efficient buildings (the so-called sick building syndrome); and even the potential of gaining insight into the dynamics of the Earth's biosphere such that we can better manage our global environment. Two specific advanced life support technologies being developed by NASA, with potential terrestrial application, are the zeoponic plant growth system and the Hybrid Regenerative Water Recovery System (HRWRS). The potential applications for these candidate dual use technologies are quite different as are the mechanisms for transfer. In the case of zeoponics, a variety of commercial applications has been suggested which represent potentially lucrative markets. Also, the patented nature of this product offers opportunities for licensing to commercial entities. In the case of the HRWRS, commercial markets with broad applications have not been identified but some terrestrial applications are being explored where this approach has advantages over other methods of waste water processing. Although these potential applications do not appear to have the same broad attraction from the standpoint of rapid commercialization, they represent niches where commercialization possibilities as well as social benefits could be realized.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keyes, D.; McInnes, L. C.; Woodward, C.

This report is an outcome of the workshop Multiphysics Simulations: Challenges and Opportunities, sponsored by the Institute of Computing in Science (ICiS). Additional information about the workshop, including relevant reading and presentations on multiphysics issues in applications, algorithms, and software, is available via https://sites.google.com/site/icismultiphysics2011/. We consider multiphysics applications from algorithmic and architectural perspectives, where 'algorithmic' includes both mathematical analysis and computational complexity and 'architectural' includes both software and hardware environments. Many diverse multiphysics applications can be reduced, en route to their computational simulation, to a common algebraic coupling paradigm. Mathematical analysis of multiphysics coupling in this form is not alwaysmore » practical for realistic applications, but model problems representative of applications discussed herein can provide insight. A variety of software frameworks for multiphysics applications have been constructed and refined within disciplinary communities and executed on leading-edge computer systems. We examine several of these, expose some commonalities among them, and attempt to extrapolate best practices to future systems. From our study, we summarize challenges and forecast opportunities. We also initiate a modest suite of test problems encompassing features present in many applications.« less

The Lone Inventor: Low Success Rates and Common Errors Associated with Pro-Se Patent Applications

PubMed Central

Gaudry, Kate S.

2012-01-01

A pro-se patent applicant is an inventor who chooses to represent himself while pursuing (“prosecuting”) a patent application. To the author's knowledge, this paper is the first empirical study addressing how applications filed by pro-se inventors fare compared to applications in which inventors were represented by patent attorneys or agents. The prosecution history of 500 patent applications filed at the United States Patent and Trademark Office were analyzed: inventors were represented by a patent professional for 250 of the applications (“represented applications”) but not in the other 250 (“pro-se applications”). 76% of the pro-se applications became abandoned (not issuing as a patent), as compared to 35% of the represented applications. Further, among applications that issued as patents, pro-se patents' claims appear to be narrower and therefore of less value than claims in the represented patent set. Case-specific data suggests that a substantial portion of pro-se applicants unintentionally abandon their applications, terminate the examination process relatively early, and/or fail to take advantage of interview opportunities that may resolve issues stalling allowance of the application. PMID:22470439

PREFACE: Focus section on superconducting power systems Focus section on superconducting power systems

NASA Astrophysics Data System (ADS)

Cardwell, D. A.; Amemiya, N.; Fair, R.

2012-01-01

This focus section of Superconductor Science and Technology looks at the properties, technology and applications of (RE)BCO and MgB2 based superconductors for power engineering systems. Both bulk and conductor forms of material are addressed, including elements of materials fabrication and processing, and the measurement of their applied properties for various levels of system application. The areas of research include ac losses in type II materials in power devices, cables and coated conductors, the development of high current dc cables and the application of superconductors in levitation devices, motors and fault current limiters. This focus section presents a broad cross-section of contemporary issues, that represent state-of-the-art for power applications of superconductors, and highlights the areas that require further development if commercial applications of these rapidly emerging materials are to be realised. It contains papers from some of the major groups in the field, including contributions from Europe, the USA and Japan, and describes devices that are relatively close to market.

20 CFR 404.1703 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... other association, including but not limited to partnerships, corporations, for-profit organizations, and not-for-profit organizations. Legal guardian or court-appointed representative means a court... representation, we determine past-due benefits before any applicable reduction under section 1127 of the Act (for...

20 CFR 404.1703 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... other association, including but not limited to partnerships, corporations, for-profit organizations, and not-for-profit organizations. Legal guardian or court-appointed representative means a court... representation, we determine past-due benefits before any applicable reduction under section 1127 of the Act (for...

76 FR 66685 - Foreign-Trade Zone 37-Orange County, NY, Application for Subzone, ITT Water Technology, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... (representing 39% of the value of the finished pumps) include: electric motors, pump parts, mechanical seals, plastic o-rings, rubber o-rings, shafts, flanges, motor and shaft couplings, and fasteners (duty rates...

Advanced automation for space missions: Technical summary

NASA Technical Reports Server (NTRS)

1980-01-01

Several representative missions which would require extensive applications of machine intelligence were identified and analyzed. The technologies which must be developed to accomplish these types of missions are discussed. These technologies include man-machine communication, space manufacturing, teleoperators, and robot systems.

Techniques for analyzing frequency selective surfaces - A review

NASA Technical Reports Server (NTRS)

Mittra, Raj; Chan, Chi H.; Cwik, Tom

1988-01-01

A number of representative techniques for analyzing frequency-selective surfaces (FSSs), which comprise periodic arrays of patches or apertures in a conducting screen and find important applications as filters in microwaves and optics, are discussed. The basic properties of the FSSs are reviewed and several different approaches to predicting their frequency-response characteristics are described. Some recent developments in the treatment of truncated, curved, and doubly periodic screens are mentioned and representative experimental results are included.

Demographic Characteristics of Applicants to, and Students of, Ontario Physiotherapy Education Programs, 2004-2014: Trends in Gender, Geographical Location, Aboriginal Identity, and Immigrant Status.

PubMed

Coghlan, Cara M; Mallinger, Hilary; McFadden, Alison; Richard, Jocelynn; Stern, Arlee; Norman, Kathleen E

2017-01-01

Purpose: The authors analyzed the demographics of potential future physiotherapists to determine whether they were representative of the Canadian population. The specific objectives were to examine selected demographic variables from all applicants to and students in Ontario English-language Master of Physical Therapy programmes in admission cycles 2004-2014, inclusive, and to analyze the results as compared with Canadian population data. Method: Anonymized applicant records ( n =14,135) were obtained for admission cycles 2004-2014, inclusive. Variables examined for applicants and students included their gender, geographical location from Canadian and international regions, Aboriginal identity, and immigrant status. A descriptive analysis of counts and proportions was conducted for all variables. Results: The majority of applicants were women (70%), from southern Ontario (73%), and Canadian born (82%). Aboriginal and rural applicants made up small proportions of the applicant pool (1% and 12%, respectively). The number of applicants from British Columbia was proportionally high relative to those from other Canadian provinces. Conclusion: Although Ontario's physiotherapy education programmes remain female dominated, the demographics of applicants and students are otherwise mostly representative of the diverse Canadian population, although very low in the number of Aboriginal peoples. Further research is needed to understand the diversity and composition of the Canadian physiotherapy workforce.

Editorial

NASA Astrophysics Data System (ADS)

Liu, Shuai

Fractal represents a special feature of nature and functional objects. However, fractal based computing can be applied to many research domains because of its fixed property resisted deformation, variable parameters and many unpredictable changes. Theoretical research and practical application of fractal based computing have been hotspots for 30 years and will be continued. There are many pending issues awaiting solutions in this domain, thus this thematic issue containing 14 papers publishes the state-of-the-art developments in theorem and application of fractal based computing, including mathematical analysis and novel engineering applications. The topics contain fractal and multifractal features in application and solution of nonlinear odes and equation.

7 CFR 97.7 - Deposit of Voucher Specimen.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PLANT VARIETY AND PROTECTION The Application § 97.7 Deposit of Voucher Specimen. (a) Voucher specimen types. As regards the deposit of voucher specimen material for purposes of plant variety protection... self-replication either directly or indirectly. Representative examples include seeds, plant tissue...

Comparison of Legislation Concerned with Basic Skills.

ERIC Educational Resources Information Center

Office of Education (DHEW), Washington, DC.

This handbook provides a comparative listing of 22 federally legislated basic skills programs. Included are the names and phone numbers of working representatives associated with each program, application deadlines, target groups, funding instruments, possible grantees, sign-off requirements, program content, technical assistance, evaluation…

20 CFR 416.1503 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... business, firm, or other association, including but not limited to partnerships, corporations, for-profit organizations, and not-for-profit organizations. Legal guardian or court-appointed representative means a court... representation, we first determine the SSI past-due benefits before any applicable reduction for reimbursement to...

20 CFR 416.1503 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... business, firm, or other association, including but not limited to partnerships, corporations, for-profit organizations, and not-for-profit organizations. Legal guardian or court-appointed representative means a court... representation, we first determine the SSI past-due benefits before any applicable reduction for reimbursement to...

7 CFR 97.7 - Deposit of Voucher Specimen.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PLANT VARIETY AND PROTECTION The Application § 97.7 Deposit of Voucher Specimen. (a) Voucher specimen types. As regards the deposit of voucher specimen material for purposes of plant variety protection... self-replication either directly or indirectly. Representative examples include seeds, plant tissue...

40 CFR 430.01 - General definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... that are representative of the application of the best practicable control technology currently available, the best conventional pollutant control technology, or new source performance standards in lieu... production at unbleached kraft mills including linerboard or bag paper and other mixed products, and to pulp...

40 CFR 430.01 - General definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... that are representative of the application of the best practicable control technology currently available, the best conventional pollutant control technology, or new source performance standards in lieu... production at unbleached kraft mills including linerboard or bag paper and other mixed products, and to pulp...

Recent advances in electrospun nanofibers for wound healing.

PubMed

Chen, Shixuan; Liu, Bing; Carlson, Mark A; Gombart, Adrian F; Reilly, Debra A; Xie, Jingwei

2017-06-01

Electrospun nanofibers represent a novel class of materials that show great potential in many biomedical applications including biosensing, regenerative medicine, tissue engineering, drug delivery and wound healing. In this work, we review recent advances in electrospun nanofibers for wound healing. This article begins with a brief introduction on the wound, and then discusses the unique features of electrospun nanofibers critical for wound healing. It further highlights recent studies that have used electrospun nanofibers for wound healing applications and devices, including sutures, multifunctional dressings, dermal substitutes, engineered epidermis and full-thickness skin regeneration. Finally, we finish with conclusions and future perspective in this field.

Wind Energy Applications and Training Symposium

NASA Astrophysics Data System (ADS)

Sixteen representatives from 11 developing nations participated in the 1990 Wind Energy Applications and Training Symposium (WEATS) program. Consistent with previous symposia, the format included classroom-style training and field trip experiences to acquaint the participants with the history and progress of wind energy development in the U.S., technologically and economically. Brief presentations about wind energy development in all the countries represented were made by the participants. Several reports were prepared and presented along with slides for further explanation. The one-on-one symposium wrap-up session on the last day continues to be a good method of discovering what can be the next step in working with each country to develop their wind energy potential. Seventeen papers have been indexed separately for inclusion on the data base.

40 CFR 270.31 - Requirements for recording and reporting of monitoring results.

Code of Federal Regulations, 2014 CFR

2014-07-01

... representative of the monitored activity including, when appropriate, continuous monitoring; (c) Applicable... reporting of monitoring results. 270.31 Section 270.31 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Permit Conditions § 270.31 Requirements for recording and reporting of monitoring results. All...

40 CFR 270.31 - Requirements for recording and reporting of monitoring results.

Code of Federal Regulations, 2011 CFR

2011-07-01

... representative of the monitored activity including, when appropriate, continuous monitoring; (c) Applicable... reporting of monitoring results. 270.31 Section 270.31 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Permit Conditions § 270.31 Requirements for recording and reporting of monitoring results. All...

40 CFR 270.31 - Requirements for recording and reporting of monitoring results.

Code of Federal Regulations, 2012 CFR

2012-07-01

... representative of the monitored activity including, when appropriate, continuous monitoring; (c) Applicable... reporting of monitoring results. 270.31 Section 270.31 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Permit Conditions § 270.31 Requirements for recording and reporting of monitoring results. All...

40 CFR 270.31 - Requirements for recording and reporting of monitoring results.

Code of Federal Regulations, 2013 CFR

2013-07-01

... representative of the monitored activity including, when appropriate, continuous monitoring; (c) Applicable... reporting of monitoring results. 270.31 Section 270.31 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Permit Conditions § 270.31 Requirements for recording and reporting of monitoring results. All...

40 CFR 270.31 - Requirements for recording and reporting of monitoring results.

Code of Federal Regulations, 2010 CFR

2010-07-01

... representative of the monitored activity including, when appropriate, continuous monitoring; (c) Applicable... reporting of monitoring results. 270.31 Section 270.31 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Permit Conditions § 270.31 Requirements for recording and reporting of monitoring results. All...

44 CFR 80.13 - Application information.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program PROPERTY ACQUISITION AND... acquisition of property for the purpose of open space must include: (1) A photograph that represents the... language, which shall be consistent with the FEMA model deed restriction that the local government will...

Parameter estimation techniques and application in aircraft flight testing

NASA Technical Reports Server (NTRS)

1974-01-01

Technical papers presented at the symposium by selected representatives from industry, universities, and various Air Force, Navy, and NASA installations are given. The topics covered include the newest developments in identification techniques, the most recent flight-test experience, and the projected potential for the near future.

Recipients of Regional Centers of Research Excellence (RCREs) P20 Grant Awards Announced

Cancer.gov

NCI, Center for Global Health (CGH) release of the applications represents novel global collaborations charged with planning and designing sustainable, Regional Centers of Research Excellence (RCREs) for non-communicable diseases, including cancer, in low- and middle-income countries (LMICs) or regions.

22 CFR 225.102 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Definitions. 225.102 Section 225.102 Foreign... representative means an individual or judicial or other body authorized under applicable law to consent on behalf... administered by the Food and Drug Administration). It does not include research activities which are...

Developing Water Sampling Standards

ERIC Educational Resources Information Center

Environmental Science and Technology, 1974

1974-01-01

Participants in the D-19 symposium on aquatic sampling and measurement for water pollution assessment were informed that determining the extent of waste water stream pollution is not a cut and dry procedure. Topics discussed include field sampling, representative sampling from storm sewers, suggested sampler features and application of improved…

Using a Freshwater Lake Model Coupled with WRF for Dynamical Downscaling Applications

EPA Science Inventory

The ability to represent extremes in temperature and precipitation in regional climates (including those affected by inland lakes) has become an area of focus as regional climate models (RCMs) simulate smaller temporal and spatial scales. When using the Weather Research and Fore...

Advances in statistics

Treesearch

Howard Stauffer; Nadav Nur

2005-01-01

The papers included in the Advances in Statistics section of the Partners in Flight (PIF) 2002 Proceedings represent a small sample of statistical topics of current importance to Partners In Flight research scientists: hierarchical modeling, estimation of detection probabilities, and Bayesian applications. Sauer et al. (this volume) examines a hierarchical model...

Science Learning: Processes and Applications.

ERIC Educational Resources Information Center

Santa, Carol Minnick, Ed.; Alvermann, Donna E., Ed.

Reflecting a collaboration in terms of content areas, levels, and audience, this volume represents the efforts of science teachers and reading teachers to understand and help one another fine tune their craft. Chapters in the volume include: (1) "Metacognition, Reading and Science Education" (Linda Baker); (2) "Science and Reading:…

Recent developments and applications of immobilized laccase.

PubMed

Fernández-Fernández, María; Sanromán, M Ángeles; Moldes, Diego

2013-12-01

Laccase is a promising biocatalyst with many possible applications, including bioremediation, chemical synthesis, biobleaching of paper pulp, biosensing, textile finishing and wine stabilization. The immobilization of enzymes offers several improvements for enzyme applications because the storage and operational stabilities are frequently enhanced. Moreover, the reusability of immobilized enzymes represents a great advantage compared with free enzymes. In this work, we discuss the different methodologies of enzyme immobilization that have been reported for laccases, such as adsorption, entrapment, encapsulation, covalent binding and self-immobilization. The applications of laccase immobilized by the aforementioned methodologies are presented, paying special attention to recent approaches regarding environmental applications and electrobiochemistry. Copyright © 2012 Elsevier Inc. All rights reserved.

Transactional Database Transformation and Its Application in Prioritizing Human Disease Genes

PubMed Central

Xiang, Yang; Payne, Philip R.O.; Huang, Kun

2013-01-01

Binary (0,1) matrices, commonly known as transactional databases, can represent many application data, including gene-phenotype data where “1” represents a confirmed gene-phenotype relation and “0” represents an unknown relation. It is natural to ask what information is hidden behind these “0”s and “1”s. Unfortunately, recent matrix completion methods, though very effective in many cases, are less likely to infer something interesting from these (0,1)-matrices. To answer this challenge, we propose IndEvi, a very succinct and effective algorithm to perform independent-evidence-based transactional database transformation. Each entry of a (0,1)-matrix is evaluated by “independent evidence” (maximal supporting patterns) extracted from the whole matrix for this entry. The value of an entry, regardless of its value as 0 or 1, has completely no effect for its independent evidence. The experiment on a gene-phenotype database shows that our method is highly promising in ranking candidate genes and predicting unknown disease genes. PMID:21422495

Automated and Assistive Tools for Accelerated Code migration of Scientific Computing on to Heterogeneous MultiCore Systems

DTIC Science & Technology

2017-04-13

modelling code, a parallel benchmark , and a communication avoiding version of the QR algorithm. Further, several improvements to the OmpSs model were...movement; and a port of the dynamic load balancing library to OmpSs. Finally, several updates to the tools infrastructure were accomplished, including: an...OmpSs: a basic algorithm on image processing applications, a mini application representative of an ocean modelling code, a parallel benchmark , and a

Audio Spectrogram Representations for Processing with Convolutional Neural Networks

NASA Astrophysics Data System (ADS)

Wyse, L.

2017-05-01

One of the decisions that arise when designing a neural network for any application is how the data should be represented in order to be presented to, and possibly generated by, a neural network. For audio, the choice is less obvious than it seems to be for visual images, and a variety of representations have been used for different applications including the raw digitized sample stream, hand-crafted features, machine discovered features, MFCCs and variants that include deltas, and a variety of spectral representations. This paper reviews some of these representations and issues that arise, focusing particularly on spectrograms for generating audio using neural networks for style transfer.

STAGS Example Problems Manual

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Rankin, Charles C.

2006-01-01

This document summarizes the STructural Analysis of General Shells (STAGS) development effort, STAGS performance for selected demonstration problems, and STAGS application problems illustrating selected advanced features available in the STAGS Version 5.0. Each problem is discussed including selected background information and reference solutions when available. The modeling and solution approach for each problem is described and illustrated. Numerical results are presented and compared with reference solutions, test data, and/or results obtained from mesh refinement studies. These solutions provide an indication of the overall capabilities of the STAGS nonlinear finite element analysis tool and provide users with representative cases, including input files, to explore these capabilities that may then be tailored to other applications.

Reader Response in the Classroom.

ERIC Educational Resources Information Center

Chew, Charles, Ed.; And Others

Focusing on reader response in the classroom, the works collected in this book represent the results of a five-week summer institute in which 25 middle school, high school, and college teachers studied the principles and applications of literature instruction. The following essays are included: an introduction by G. Garber; "An Overview of the…

A Comparison of Statistical Techniques for Combining Modeled and Observed Concentrations to Create High-Resolution Ozone Air Quality Surfaces

EPA Science Inventory

Air quality surfaces representing pollutant concentrations across space and time are needed for many applications, including tracking trends and relating air quality to human and ecosystem health. The spatial and temporal characteristics of these surfaces may reveal new informat...

14 CFR 1245.202 - Contents of communication initiating claim.

Code of Federal Regulations, 2013 CFR

2013-01-01

... claim for compensation, asserted against the United States as represented by NASA under any of the... within a NASA Center. Claims must be in writing and must include the following: (1) An allegation of... corresponding foreign patents and patent applications and full copies of the same. (11) Pertinent prior art...

77 FR 38017 - Regulation Strengthening Accountability of Attorneys and Non-Attorney Representatives Appearing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... disciplinary action for misconduct based upon good cause. The proposed rule will assist the Department in maintaining the integrity of its proceedings by deterring misconduct by those who appear before it in... application of sanctions for misconduct, (ii) identifies possible sanctions for misconduct including...

US/USSR SYMPOSIUM ON PARTICULATE CONTROL (SECOND) HELD AT RESEARCH TRIANGLE PARK, NORTH CAROLINA ON MAY 25-28, 1977

EPA Science Inventory

Papers were presented by Soviet specialists from research design institutes and industry, and by representatives of US government agencies and the private sector. Topics included: electrostatic precipitator (ESP) research and application, ESP gas flow modeling, ESP rapping and re...

40 CFR 408.207 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... control technology. 408.207 Section 408.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... degree of effluent reduction attainable by the application of the best conventional pollutant control... processing facility located in population or processing centers including but not limited to Anchorage...

40 CFR 408.207 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... control technology. 408.207 Section 408.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... degree of effluent reduction attainable by the application of the best conventional pollutant control... processing facility located in population or processing centers including but not limited to Anchorage...

40 CFR 408.297 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... control technology. 408.297 Section 408.297 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... of effluent reduction attainable by the application of the best conventional pollutant control... facility located in population or processing centers including but not limited to Anchorage, Cordova...

40 CFR 408.207 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... control technology. 408.207 Section 408.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... degree of effluent reduction attainable by the application of the best conventional pollutant control... processing facility located in population or processing centers including but not limited to Anchorage...

40 CFR 408.207 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... control technology. 408.207 Section 408.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... degree of effluent reduction attainable by the application of the best conventional pollutant control... processing facility located in population or processing centers including but not limited to Anchorage...

40 CFR 408.297 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... control technology. 408.297 Section 408.297 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... of effluent reduction attainable by the application of the best conventional pollutant control... facility located in population or processing centers including but not limited to Anchorage, Cordova...

40 CFR 408.207 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... control technology. 408.207 Section 408.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... degree of effluent reduction attainable by the application of the best conventional pollutant control... processing facility located in population or processing centers including but not limited to Anchorage...

40 CFR 408.297 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... control technology. 408.297 Section 408.297 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... of effluent reduction attainable by the application of the best conventional pollutant control... facility located in population or processing centers including but not limited to Anchorage, Cordova...

40 CFR 408.297 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... control technology. 408.297 Section 408.297 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... of effluent reduction attainable by the application of the best conventional pollutant control... facility located in population or processing centers including but not limited to Anchorage, Cordova...

40 CFR 408.297 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... control technology. 408.297 Section 408.297 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... of effluent reduction attainable by the application of the best conventional pollutant control... facility located in population or processing centers including but not limited to Anchorage, Cordova...

Development of a standardized protein immunomarking protocol for insect mark-capture dispersal research

USDA-ARS?s Scientific Manuscript database

A field study was conducted to test the marking efficiency of broadcast spray applications of protein marks on stationary (represented by cadavers) and free-roaming lady beetles, Hippodamia convergens Guérin-Méneville that were strategically placed in blooming alfalfa plots. The marks tested include...

Computer-Assisted Instruction. Special Double Issue.

ERIC Educational Resources Information Center

Holmes, Glyn, Ed.

1984-01-01

This booklet presents evidence to support the idea that distinctions between the instructional and research applications of the computer are becoming blurred. The issue includes contributions from authors who are at the forefront of computer-assisted instruction (CAI) development in their respective fields. An attempt is made to represent most…

76 FR 40679 - Household Water Well System Grant Program Announcement of Application Deadlines and Funding

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... registers your organization, housing your organizational information and allowing Grants.gov to use the... representative, and have original signatures. Do not include organizational brochures or promotional materials. 2... Up to 20 points. demonstrates a well thought out, comprehensive approach to accomplishing the...

32 CFR 865.3 - Application procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (DD Form 149) and http://www.e-publishing.af.mil/shared/media/epubs/AFPAM36-2607.pdf (Air Force...) The name under which the member served. (2) The member's social security number or Air Force service... term “counsel” includes members in good standing of the bar of any state, accredited representatives of...

32 CFR 865.3 - Application procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (DD Form 149) and http://www.e-publishing.af.mil/shared/media/epubs/AFPAM36-2607.pdf (Air Force...) The name under which the member served. (2) The member's social security number or Air Force service... term “counsel” includes members in good standing of the bar of any state, accredited representatives of...

32 CFR 865.3 - Application procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (DD Form 149) and http://www.e-publishing.af.mil/shared/media/epubs/AFPAM36-2607.pdf (Air Force...) The name under which the member served. (2) The member's social security number or Air Force service... term “counsel” includes members in good standing of the bar of any state, accredited representatives of...

32 CFR 865.3 - Application procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (DD Form 149) and http://www.e-publishing.af.mil/shared/media/epubs/AFPAM36-2607.pdf (Air Force...) The name under which the member served. (2) The member's social security number or Air Force service... term “counsel” includes members in good standing of the bar of any state, accredited representatives of...

49 CFR 1242.05 - Operating expense account number notation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... group signifies applicable function assignment. ec03mr91.050 (b) For reporting purposes, four natural..., tools, supplies, fuels and lubricants (account 21-XX-XX); purchased services (accounts 31-XX-XX to 41-XX... account structure. For reporting purposes, the natural expense account numbers represented by “XX” include...

49 CFR 1242.05 - Operating expense account number notation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... group signifies applicable function assignment. ec03mr91.050 (b) For reporting purposes, four natural..., tools, supplies, fuels and lubricants (account 21-XX-XX); purchased services (accounts 31-XX-XX to 41-XX... account structure. For reporting purposes, the natural expense account numbers represented by “XX” include...

49 CFR 1242.05 - Operating expense account number notation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... group signifies applicable function assignment. ec03mr91.050 (b) For reporting purposes, four natural..., tools, supplies, fuels and lubricants (account 21-XX-XX); purchased services (accounts 31-XX-XX to 41-XX... account structure. For reporting purposes, the natural expense account numbers represented by “XX” include...

49 CFR 1242.05 - Operating expense account number notation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... group signifies applicable function assignment. ec03mr91.050 (b) For reporting purposes, four natural..., tools, supplies, fuels and lubricants (account 21-XX-XX); purchased services (accounts 31-XX-XX to 41-XX... account structure. For reporting purposes, the natural expense account numbers represented by “XX” include...

Interaction Analysis: Theory, Research and Application.

ERIC Educational Resources Information Center

Amidon, Edmund J., Ed.; Hough, John J., Ed.

This volume of selected readings developed for students and practitioners at various levels of sophistication is intended to be representative of work done to date on interaction analysis. The contents include journal articles, papers read at professional meetings, abstracts of doctoral dissertations, and selections from larger monographs, plus 12…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Portone, Teresa; Niederhaus, John Henry; Sanchez, Jason James

This report introduces the concepts of Bayesian model selection, which provides a systematic means of calibrating and selecting an optimal model to represent a phenomenon. This has many potential applications, including for comparing constitutive models. The ideas described herein are applied to a model selection problem between different yield models for hardened steel under extreme loading conditions.

Survey of techniques used to preserve biological materials

NASA Technical Reports Server (NTRS)

Feinler, E. J.; Hubbard, R. W.

1972-01-01

The techniques used to preserve biological materials are documented and summarized. The report is presented in a handbook format that categorizes the most important preservation techniques available, and includes a representative sampling of the thousands of applications of these techniques to biological materials and organisms. Details of the information coverage and method of approach are outlined. Data are given in tabular form, and an index and extensive bibliography are included.

Retrofit photovoltaic systems for intermediate sized applications - A design and market study

NASA Astrophysics Data System (ADS)

Noel, G. T.; Hagely, J. R.

An assessment of the technical and economic feasibility of retrofitting a significant portion of the existing intermediate sector building/application inventory with photovoltaic systems is presented. The assessment includes the development of detailed engineering and architectural designs as well as cost estimates for 12 representative installations. Promising applications include retail stores, warehouses, office buildings, religious buildings, shopping centers, education buildings, hospitals, and industrial sites. A market study indicates that there is a national invetory of 1.5 to 2.0 million feasible intermediate sector applications, with the majority being in the 20 to 400 kW size range. The present cost of the major systems components and the cost of necessary building modifications are the primary current barriers to the realization of a large retrofit photovoltaic system market. The development of standardized modular system designs and installation techniques are feasible ways to minimize costs.

GeoSciML version 3: A GML application for geologic information

NASA Astrophysics Data System (ADS)

International Union of Geological Sciences., I. C.; Richard, S. M.

2011-12-01

After 2 years of testing and development, XML schema for GeoSciML version 3 are now ready for application deployment. GeoSciML draws from many geoscience data modelling efforts to establish a common suite of feature types to represent information associated with geologic maps (materials, structures, and geologic units) and observations including structure data, samples, and chemical analyses. After extensive testing and use case analysis, in December 2008 the CGI Interoperability Working Group (IWG) released GeoSciML 2.0 as an application schema for basic geological information. GeoSciML 2.0 is in use to deliver geologic data by the OneGeology Europe portal, the Geological Survey of Canada Groundwater Information Network (wet GIN), and the Auscope Mineral Resources portal. GeoSciML to version 3.0 is updated to OGC Geography Markup Language v3.2, re-engineered patterns for association of element values with controlled vocabulary concepts, incorporation of ISO19156 Observation and Measurement constructs for representing numeric and categorical values and for representing analytical data, incorporation of EarthResourceML to represent mineral occurrences and mines, incorporation of the GeoTime model to represent GSSP and stratigraphic time scale, and refactoring of the GeoSciML namespace to follow emerging ISO practices for decoupling of dependencies between standardized namespaces. These changes will make it easier for data providers to link to standard vocabulary and registry services. The depth and breadth of GeoSciML remains largely unchanged, covering the representation of geologic units, earth materials and geologic structures. ISO19156 elements and patterns are used to represent sampling features such as boreholes and rock samples, as well as geochemical and geochronologic measurements. Geologic structures include shear displacement structures (brittle faults and ductile shears), contacts, folds, foliations, lineations and structures with no preferred orientation (e.g. 'miarolitic cavities'). The Earth material package allows for the description of both individual components, such as minerals, and compound materials, such as rocks or unconsolidated materials. Provision is made for alteration, weathering, metamorphism, particle geometry, fabric, and petrophysical descriptions. Mapped features describe the shape of the geological features using standard GML geometries, such as polygons, lines, points or 3D volumes. Geological events provide the age, process and environment of formation of geological features. The Earth Resource section includes features to represent mineral occurrences and mines and associated human activities independently. This addition allows description of resources and reserves that can comply with national and internationally accepted reporting codes. GeoSciML v3 is under consideration as the data model for INSPIRE annex 2 geologic reporting in Europe.

40 CFR 434.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by...

Code of Federal Regulations, 2014 CFR

2014-07-01

... representing the degree of effluent reduction attainable by application of the best available technology... representing the degree of effluent reduction attainable by application of the best available technology... application of the best available technology economically achievable: BAT Effluent Limitations Pollutant or...

40 CFR 434.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by...

Code of Federal Regulations, 2012 CFR

2012-07-01

... representing the degree of effluent reduction attainable by application of the best available technology... representing the degree of effluent reduction attainable by application of the best available technology... application of the best available technology economically achievable: BAT Effluent Limitations Pollutant or...

40 CFR 434.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by...

Code of Federal Regulations, 2011 CFR

2011-07-01

... representing the degree of effluent reduction attainable by application of the best available technology... representing the degree of effluent reduction attainable by application of the best available technology... application of the best available technology economically achievable: BAT Effluent Limitations Pollutant or...

40 CFR 434.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by application of the best available technology... representing the degree of effluent reduction attainable by application of the best available technology... application of the best available technology economically achievable: BAT Effluent Limitations Pollutant or...

40 CFR 408.172 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.172 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.162 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.312 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.162 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.312 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.162 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.312 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.312 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.172 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.312 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... representing the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

Review of Estelle and LOTOS with respect to critical computer applications

NASA Technical Reports Server (NTRS)

Bown, Rodney L.

1991-01-01

Man rated NASA space vehicles seem to represent a set of ultimate critical computer applications. These applications require a high degree of security, integrity, and safety. A variety of formal and/or precise modeling techniques are becoming available for the designer of critical systems. The design phase of the software engineering life cycle includes the modification of non-development components. A review of the Estelle and LOTOS formal description languages is presented. Details of the languages and a set of references are provided. The languages were used to formally describe some of the Open System Interconnect (OSI) protocols.

Modeling and visualizing borehole information on virtual globes using KML

NASA Astrophysics Data System (ADS)

Zhu, Liang-feng; Wang, Xi-feng; Zhang, Bing

2014-01-01

Advances in virtual globes and Keyhole Markup Language (KML) are providing the Earth scientists with the universal platforms to manage, visualize, integrate and disseminate geospatial information. In order to use KML to represent and disseminate subsurface geological information on virtual globes, we present an automatic method for modeling and visualizing a large volume of borehole information. Based on a standard form of borehole database, the method first creates a variety of borehole models with different levels of detail (LODs), including point placemarks representing drilling locations, scatter dots representing contacts and tube models representing strata. Subsequently, the level-of-detail based (LOD-based) multi-scale representation is constructed to enhance the efficiency of visualizing large numbers of boreholes. Finally, the modeling result can be loaded into a virtual globe application for 3D visualization. An implementation program, termed Borehole2KML, is developed to automatically convert borehole data into KML documents. A case study of using Borehole2KML to create borehole models in Shanghai shows that the modeling method is applicable to visualize, integrate and disseminate borehole information on the Internet. The method we have developed has potential use in societal service of geological information.

Geocoded data structures and their applications to Earth science investigations

NASA Technical Reports Server (NTRS)

Goldberg, M.

1984-01-01

A geocoded data structure is a means for digitally representing a geographically referenced map or image. The characteristics of representative cellular, linked, and hybrid geocoded data structures are reviewed. The data processing requirements of Earth science projects at the Goddard Space Flight Center and the basic tools of geographic data processing are described. Specific ways that new geocoded data structures can be used to adapt these tools to scientists' needs are presented. These include: expanding analysis and modeling capabilities; simplifying the merging of data sets from diverse sources; and saving computer storage space.

Web-based application for inverting one-dimensional magnetotelluric data using Python

NASA Astrophysics Data System (ADS)

Suryanto, Wiwit; Irnaka, Theodosius Marwan

2016-11-01

One-dimensional modeling of magnetotelluric (MT) data has been performed using an online application on a web-based virtual private server. The application was developed with the Python language using the Django framework with HTML and CSS components. The input data, including the apparent resistivity and phase as a function of period or frequency with standard deviation, can be entered through an interactive web page that can be freely accessed at https://komputasi.geofisika.ugm.ac.id. The subsurface models, represented by resistivity as a function of depth, are iteratively improved by changing the model parameters, such as the resistivity and the layer depth, based on the observed apparent resistivity and phase data. The output of the application displayed on the screen presents resistivity as a function of depth and includes the RMS error for each iteration. Synthetic and real data were used in comparative tests of the application's performance, and it is shown that the application developed accurate subsurface resistivity models. Hence, this application can be used for practical one-dimensional modeling of MT data.

Genoviz Software Development Kit: Java tool kit for building genomics visualization applications.

PubMed

Helt, Gregg A; Nicol, John W; Erwin, Ed; Blossom, Eric; Blanchard, Steven G; Chervitz, Stephen A; Harmon, Cyrus; Loraine, Ann E

2009-08-25

Visualization software can expose previously undiscovered patterns in genomic data and advance biological science. The Genoviz Software Development Kit (SDK) is an open source, Java-based framework designed for rapid assembly of visualization software applications for genomics. The Genoviz SDK framework provides a mechanism for incorporating adaptive, dynamic zooming into applications, a desirable feature of genome viewers. Visualization capabilities of the Genoviz SDK include automated layout of features along genetic or genomic axes; support for user interactions with graphical elements (Glyphs) in a map; a variety of Glyph sub-classes that promote experimentation with new ways of representing data in graphical formats; and support for adaptive, semantic zooming, whereby objects change their appearance depending on zoom level and zooming rate adapts to the current scale. Freely available demonstration and production quality applications, including the Integrated Genome Browser, illustrate Genoviz SDK capabilities. Separation between graphics components and genomic data models makes it easy for developers to add visualization capability to pre-existing applications or build new applications using third-party data models. Source code, documentation, sample applications, and tutorials are available at http://genoviz.sourceforge.net/.

Editorial: Functional nanomaterials for energy applications

DOE PAGES

Devan, Rupesh S.; Ma, Yuan -Ron; Kim, Jin -Hyeok; ...

2015-02-16

In order to leap forward from the energy crisis issues and improve lifestyle, we all are looking positively toward nanomaterials or nanostructures. Thus, the exploration of new features of both typical and novel materials at the nanoscale level is playing important role in the development of innovative and improved energy technologies that have the capability of conserve/convert energy at large extend. By tailoring the surface morphology of materials in its nanoforms, the functional properties can be significantly adapted and specifically combined to produce highly potent multifunctional materials for conversion, storage, and consumption of energy in various forms. The papers selectedmore » for this special issue represent a good panel for addressing various energy applications including solar cell, fuel cells, nanofluid twisters, and gas sensors. Of course, the selected topic and the papers are not an exhaustive representation of the utilization of functional nanomaterials for energy applications. Nevertheless, they represent the rich and many-facet knowledge, which we have the pleasure of sharing with the readers.« less

Human adipose-derived stem cells: definition, isolation, tissue-engineering applications.

PubMed

Nae, S; Bordeianu, I; Stăncioiu, A T; Antohi, N

2013-01-01

Recent researches have demonstrated that the most effective repair system of the body is represented by stem cells - unspecialized cells, capable of self-renewal through successive mitoses, which have also the ability to transform into different cell types through differentiation. The discovery of adult stem cells represented an important step in regenerative medicine because they no longer raises ethical or legal issues and are more accessible. Only in 2002, stem cells isolated from adipose tissue were described as multipotent stem cells. Adipose tissue stem cells benefits in tissue engineering and regenerative medicine are numerous. Development of adipose tissue engineering techniques offers a great potential in surpassing the existing limits faced by the classical approaches used in plastic and reconstructive surgery. Adipose tissue engineering clinical applications are wide and varied, including reconstructive, corrective and cosmetic procedures. Nowadays, adipose tissue engineering is a fast developing field, both in terms of fundamental researches and medical applications, addressing issues related to current clinical pathology or trauma management of soft tissue injuries in different body locations.

Space Science: Past, Present and Future. Report Prepared by the Subcommittee on Space Science and Applications. Transmitted to the Committee on Science and Technology, House of Representatives, Ninety-Ninth Congress, Second Session, Serial O.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Science and Technology.

Congressional hearings held on October 8-10, 1985, were meant to characterize the attributes of past successes of the United States' efforts in the space sciences, and to project the direction of future research in that area. This report prepared by the subcommittee on space science and application includes recommendations of expert panels on…

Simulation of eye disease in virtual reality.

PubMed

Jin, Bei; Ai, Zhuming; Rasmussen, Mary

2005-01-01

It is difficult to understand verbal descriptions of visual phenomenon if one has no such experience. Virtual Reality offers a unique opportunity to "experience" diminished vision and the problems it causes in daily life. We have developed an application to simulate age-related macular degeneration, glaucoma, protanopia, and diabetic retinopathy in a familiar setting. The application also includes the introduction of eye anatomy representing both normal and pathologic states. It is designed for patient education, health care practitioner training, and eye care specialist education.

Method and apparatus for modeling interactions

DOEpatents

Xavier, Patrick G.

2000-08-08

A method and apparatus for modeling interactions between bodies. The method comprises representing two bodies undergoing translations and rotations by two hierarchical swept volume representations. Interactions such as nearest approach and collision can be modeled based on the swept body representations. The present invention can serve as a practical tool in motion planning, CAD systems, simulation systems, safety analysis, and applications that require modeling time-based interactions. A body can be represented in the present invention by a union of convex polygons and convex polyhedra. As used generally herein, polyhedron includes polygon, and polyhedra includes polygons. The body undergoing translation can be represented by a swept body representation, where the swept body representation comprises a hierarchical bounding volume representation whose leaves each contain a representation of the region swept by a section of the body during the translation, and where the union of the regions is a superset of the region swept by the surface of the body during translation. Interactions between two bodies thus represented can be modeled by modeling interactions between the convex hulls of the finite sets of discrete points in the swept body representations.

View generated database

NASA Technical Reports Server (NTRS)

Downward, James G.

1992-01-01

This document represents the final report for the View Generated Database (VGD) project, NAS7-1066. It documents the work done on the project up to the point at which all project work was terminated due to lack of project funds. The VGD was to provide the capability to accurately represent any real-world object or scene as a computer model. Such models include both an accurate spatial/geometric representation of surfaces of the object or scene, as well as any surface detail present on the object. Applications of such models are numerous, including acquisition and maintenance of work models for tele-autonomous systems, generation of accurate 3-D geometric/photometric models for various 3-D vision systems, and graphical models for realistic rendering of 3-D scenes via computer graphics.

International Space Station Earth Observations Working Group

NASA Technical Reports Server (NTRS)

Stefanov, William L.; Oikawa, Koki

2015-01-01

The multilateral Earth Observations Working Group (EOWG) was chartered in May 2012 in order to improve coordination and collaboration of Earth observing payloads, research, and applications on the International Space Station (ISS). The EOWG derives its authority from the ISS Program Science Forum, and a NASA representative serves as a permanent co-chair. A rotating co-chair position can be occupied by any of the international partners, following concurrence by the other partners; a JAXA representative is the current co-chair. Primary functions of the EOWG include, 1) the exchange of information on plans for payloads, from science and application objectives to instrument development, data collection, distribution and research; 2) recognition and facilitation of opportunities for international collaboration in order to optimize benefits from different instruments; and 3) provide a formal ISS Program interface for collection and application of remotely sensed data collected in response to natural disasters through the International Charter, Space and Major Disasters. Recent examples of EOWG activities include coordination of bilateral data sharing protocols between NASA and TsNIIMash for use of crew time and instruments in support of ATV5 reentry imaging activities; discussion of continued use and support of the Nightpod camera mount system by NASA and ESA; and review and revision of international partner contributions on Earth observations to the ISS Program Benefits to Humanity publication.

20 CFR 217.19 - Representative of the claimant selected after application is filed.

Code of Federal Regulations, 2010 CFR

2010-04-01

... representative. However, benefits will be paid using the filing date of the original benefit application. (b... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Representative of the claimant selected after application is filed. 217.19 Section 217.19 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER...

Catalysts for use in electrochemical applications and electrodes and devices using same

DOEpatents

Ozkan, Umit S.; von Deak, Dieter; Biddinger, Elizabeth

2015-09-15

An electrode for reduction of an oxidant including a phosphorus-doped carbon-containing catalyst represented by the chemical formula CN.sub.xP.sub.y, where x is from 0 to about 10 wt. % and y is from about 1 ppm to about 10 wt. %. A device for producing electricity by facilitating an electrochemical reaction between a fuel and an oxidant. The device including a first electrode for oxidizing the fuel to produce protons and electrons. The device further includes a second electrode in electrical communication with the first electrode when electrically connected to the external circuit. The second electrode includes a phosphorus-doped carbon-containing catalyst for reducing the oxidant and is represented by the chemical formula CN.sub.xP.sub.y, where x is from 0 to about 10 wt. % and y is from about 1 ppm to about 10 wt. %. The device further includes an electrolyte, such as, a membrane, separating the first electrode from the second electrode.

Endoscopic optical coherence tomography: technologies and clinical applications [Invited

PubMed Central

Gora, Michalina J.; Suter, Melissa J.; Tearney, Guillermo J.; Li, Xingde

2017-01-01

In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. PMID:28663882

47 CFR 61.1 - Purpose and application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... carrier or carrier representative shall have ten (10) business days from the date of filing to amend the cover letter or transmittal to include a valid FRN. If within that ten (10) business day period, the... expiration of the ten (10) business day period, the cover letter or transmittal has not been amended to...

Discovery '84: Technology for Disabled Persons. Conference Papers (Chicago, Illinois, October 1-3, 1984).

ERIC Educational Resources Information Center

Smith, Christopher, Ed.

Thirty-nine papers from the conference "Discovery '84: Technology for Disabled Persons" are presented. The conference was intended to provide an overview of the areas in which technological advances have been made, including the applications of computers and other related products and services. Conference presenters represented fields of…

Computer Security and the Data Encryption Standard. Proceedings of the Conference on Computer Security and the Data Encryption Standard.

ERIC Educational Resources Information Center

Branstad, Dennis K., Ed.

The 15 papers and summaries of presentations in this collection provide technical information and guidance offered by representatives from federal agencies and private industry. Topics discussed include physical security, risk assessment, software security, computer network security, and applications and implementation of the Data Encryption…

Application of an integrated strategy for monitoring of contaminants, including endocrine active chemicals, in Great Lakes Areas of Concern

EPA Science Inventory

Chemical monitoring strategies are most effective for those chemicals whose hazards are well understood and for which sensitive and cost effective analytical methods are available. Unfortunately, such chemicals represent a minor fraction of those that may currently occur in the e...

77 FR 43601 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-25

... of the patent applications. Novel Analogues of the Asthma Drug Fenoterol as Liver and Brain Cancer... as MNF, that inhibit the growth of various types of cancers, including brain, liver, colon, and lung..., represents one of the first potential drugs directed at this target. MNF crosses the blood brain barrier and...

31 CFR 205.20 - What is a clearance pattern?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., unless additional data is required to accurately represent the flow of Federal funds. (e) If a State uses... FEDERAL-STATE FUNDS TRANSFERS Rules Applicable to Federal Assistance Programs Included in a Treasury-State Agreement § 205.20 What is a clearance pattern? States use clearance patterns to project when funds are paid...

Complex Adaptive Systems Based Data Integration: Theory and Applications

ERIC Educational Resources Information Center

Rohn, Eliahu

2008-01-01

Data Definition Languages (DDLs) have been created and used to represent data in programming languages and in database dictionaries. This representation includes descriptions in the form of data fields and relations in the form of a hierarchy, with the common exception of relational databases where relations are flat. Network computing created an…

40 CFR 420.12 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... best practicable control technology currently available. (a) By-product cokemaking—iron and steel... for by-product coke plants which have wet desulfurization systems but only to the extent such systems... limitations, are allowed for by-product coke plants which include indirect ammonia recovery systems but only...

Color image processing and object tracking workstation

NASA Technical Reports Server (NTRS)

Klimek, Robert B.; Paulick, Michael J.

1992-01-01

A system is described for automatic and semiautomatic tracking of objects on film or video tape which was developed to meet the needs of the microgravity combustion and fluid science experiments at NASA Lewis. The system consists of individual hardware parts working under computer control to achieve a high degree of automation. The most important hardware parts include 16 mm film projector, a lens system, a video camera, an S-VHS tapedeck, a frame grabber, and some storage and output devices. Both the projector and tapedeck have a computer interface enabling remote control. Tracking software was developed to control the overall operation. In the automatic mode, the main tracking program controls the projector or the tapedeck frame incrementation, grabs a frame, processes it, locates the edge of the objects being tracked, and stores the coordinates in a file. This process is performed repeatedly until the last frame is reached. Three representative applications are described. These applications represent typical uses and include tracking the propagation of a flame front, tracking the movement of a liquid-gas interface with extremely poor visibility, and characterizing a diffusion flame according to color and shape.

StrBioLib: a Java library for development of custom computational structural biology applications.

PubMed

Chandonia, John-Marc

2007-08-01

StrBioLib is a library of Java classes useful for developing software for computational structural biology research. StrBioLib contains classes to represent and manipulate protein structures, biopolymer sequences, sets of biopolymer sequences, and alignments between biopolymers based on either sequence or structure. Interfaces are provided to interact with commonly used bioinformatics applications, including (psi)-blast, modeller, muscle and Primer3, and tools are provided to read and write many file formats used to represent bioinformatic data. The library includes a general-purpose neural network object with multiple training algorithms, the Hooke and Jeeves non-linear optimization algorithm, and tools for efficient C-style string parsing and formatting. StrBioLib is the basis for the Pred2ary secondary structure prediction program, is used to build the astral compendium for sequence and structure analysis, and has been extensively tested through use in many smaller projects. Examples and documentation are available at the site below. StrBioLib may be obtained under the terms of the GNU LGPL license from http://strbio.sourceforge.net/

Use of model calibration to achieve high accuracy in analysis of computer networks

DOEpatents

Frogner, Bjorn; Guarro, Sergio; Scharf, Guy

2004-05-11

A system and method are provided for creating a network performance prediction model, and calibrating the prediction model, through application of network load statistical analyses. The method includes characterizing the measured load on the network, which may include background load data obtained over time, and may further include directed load data representative of a transaction-level event. Probabilistic representations of load data are derived to characterize the statistical persistence of the network performance variability and to determine delays throughout the network. The probabilistic representations are applied to the network performance prediction model to adapt the model for accurate prediction of network performance. Certain embodiments of the method and system may be used for analysis of the performance of a distributed application characterized as data packet streams.

Recent Advances in Glycerol Polymers: Chemistry and Biomedical Applications

PubMed Central

Zhang, Heng

2015-01-01

Glycerol polymers are attracting increased attention due to the diversity of polymer compositions and architectures available. This article provides a brief chronological review on the current status of these polymers along with representative examples of their use for biomedical applications. First, we describe the underlying chemistry of glycerol, which provides access to a range of monomers for subsequent polymerizations. We then review the various synthetic methodologies to prepare glycerol-based polymers including polyethers, polycarbonates, polyesters, and so forth. Next, we describe several biomedical applications where glycerol polymers are being investigated including carriers for drug delivery, sealants or coatings for tissue repair, and agents possessing antibacterial activity. Fourth, we describe the growing market opportunity for the use of polymers in medicine. Finally we conclude and summarize the findings, as well as discuss potential opportunities for continued research efforts. PMID:25308354

Applications of DART-MS for food quality and safety assurance in food supply chain.

PubMed

Guo, Tianyang; Yong, Wei; Jin, Yong; Zhang, Liya; Liu, Jiahui; Wang, Sai; Chen, Qilong; Dong, Yiyang; Su, Haijia; Tan, Tianwei

2017-03-01

Direct analysis in real time (DART) represents a new generation of ion source which is used for rapid ionization of small molecules under ambient conditions. The combination of DART and various mass spectrometers allows analyzing multiple food samples with simple or no sample treatment, or in conjunction with prevailing protocolized sample preparation methods. Abundant applications by DART-MS have been reviewed in this paper. The DART-MS strategy applied to food supply chain (FSC), including production, processing, and storage and transportation, provides a comprehensive solution to various food components, contaminants, authenticity, and traceability. Additionally, typical applications available in food analysis by other ambient ionization mass spectrometers were summarized, and fundamentals mainly including mechanisms, devices, and parameters were discussed as well. © 2015 Wiley Periodicals, Inc. Mass Spec Rev. 36:161-187, 2017. © 2015 Wiley Periodicals, Inc.

Materials process and applications of single grain (RE)-Ba-Cu-O bulk high-temperature superconductors

NASA Astrophysics Data System (ADS)

Li, Beizhan; Zhou, Difan; Xu, Kun; Hara, Shogo; Tsuzuki, Keita; Miki, Motohiro; Felder, Brice; Deng, Zigang; Izumi, Mitsuru

2012-11-01

This paper reviews recent advances in the melt process of (RE)-Ba-Cu-O [(RE)BCO, where RE represents a rare earth element] single grain high-temperature superconductors (HTSs), bulks and its applications. The efforts on the improvement of the magnetic flux pinning with employing the top-seeded melt-growth process technique and using a seeded infiltration and growth process are discussed. Which including various chemical doping strategies and controlled pushing effect based on the peritectic reaction of (RE)BCO. The typical experiment results, such as the largest single domain bulk, the clear TEM observations and the significant critical current density, are summarized together with the magnetization techniques. Finally, we highlight the recent prominent progress of HTS bulk applications, including Maglev, flywheel, power device, magnetic drug delivery system and magnetic resonance devices.

ROSE Version 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quinlan, D.; Yi, Q.; Buduc, R.

2005-02-17

ROSE is an object-oriented software infrastructure for source-to-source translation that provides an interface for programmers to write their own specialized translators for optimizing scientific applications. ROSE is a part of current research on telescoping languages, which provides optimizations of the use of libraries in scientific applications. ROSE defines approaches to extend the optimization techniques, common in well defined languages, to the optimization of scientific applications using well defined libraries. ROSE includes a rich set of tools for generating customized transformations to support optimization of applications codes. We currently support full C and C++ (including template instantiation etc.), with Fortran 90more » support under development as part of a collaboration and contract with Rice to use their version of the open source Open64 F90 front-end. ROSE represents an attempt to define an open compiler infrastructure to handle the full complexity of full scale DOE applications codes using the languages common to scientific computing within DOE. We expect that such an infrastructure will also be useful for the development of numerous tools that may then realistically expect to work on DOE full scale applications.« less

SimGen: A General Simulation Method for Large Systems.

PubMed

Taylor, William R

2017-02-03

SimGen is a stand-alone computer program that reads a script of commands to represent complex macromolecules, including proteins and nucleic acids, in a structural hierarchy that can then be viewed using an integral graphical viewer or animated through a high-level application programming interface in C++. Structural levels in the hierarchy range from α-carbon or phosphate backbones through secondary structure to domains, molecules, and multimers with each level represented in an identical data structure that can be manipulated using the application programming interface. Unlike most coarse-grained simulation approaches, the higher-level objects represented in SimGen can be soft, allowing the lower-level objects that they contain to interact directly. The default motion simulated by SimGen is a Brownian-like diffusion that can be set to occur across all levels of representation in the hierarchy. Links can also be defined between objects, which, when combined with large high-level random movements, result in an effective search strategy for constraint satisfaction, including structure prediction from predicted pairwise distances. The implementation of SimGen makes use of the hierarchic data structure to avoid unnecessary calculation, especially for collision detection, allowing it to be simultaneously run and viewed on a laptop computer while simulating large systems of over 20,000 objects. It has been used previously to model complex molecular interactions including the motion of a myosin-V dimer "walking" on an actin fibre, RNA stem-loop packing, and the simulation of cell motion and aggregation. Several extensions to this original functionality are described. Copyright © 2016 The Francis Crick Institute. Published by Elsevier Ltd.. All rights reserved.

Review of Zero-D and 1-D Models of Blood Flow in the Cardiovascular System

PubMed Central

2011-01-01

Background Zero-dimensional (lumped parameter) and one dimensional models, based on simplified representations of the components of the cardiovascular system, can contribute strongly to our understanding of circulatory physiology. Zero-D models provide a concise way to evaluate the haemodynamic interactions among the cardiovascular organs, whilst one-D (distributed parameter) models add the facility to represent efficiently the effects of pulse wave transmission in the arterial network at greatly reduced computational expense compared to higher dimensional computational fluid dynamics studies. There is extensive literature on both types of models. Method and Results The purpose of this review article is to summarise published 0D and 1D models of the cardiovascular system, to explore their limitations and range of application, and to provide an indication of the physiological phenomena that can be included in these representations. The review on 0D models collects together in one place a description of the range of models that have been used to describe the various characteristics of cardiovascular response, together with the factors that influence it. Such models generally feature the major components of the system, such as the heart, the heart valves and the vasculature. The models are categorised in terms of the features of the system that they are able to represent, their complexity and range of application: representations of effects including pressure-dependent vessel properties, interaction between the heart chambers, neuro-regulation and auto-regulation are explored. The examination on 1D models covers various methods for the assembly, discretisation and solution of the governing equations, in conjunction with a report of the definition and treatment of boundary conditions. Increasingly, 0D and 1D models are used in multi-scale models, in which their primary role is to provide boundary conditions for sophisticate, and often patient-specific, 2D and 3D models, and this application is also addressed. As an example of 0D cardiovascular modelling, a small selection of simple models have been represented in the CellML mark-up language and uploaded to the CellML model repository http://models.cellml.org/. They are freely available to the research and education communities. Conclusion Each published cardiovascular model has merit for particular applications. This review categorises 0D and 1D models, highlights their advantages and disadvantages, and thus provides guidance on the selection of models to assist various cardiovascular modelling studies. It also identifies directions for further development, as well as current challenges in the wider use of these models including service to represent boundary conditions for local 3D models and translation to clinical application. PMID:21521508

Development of National Map ontologies for organization and orchestration of hydrologic observations

NASA Astrophysics Data System (ADS)

Lieberman, J. E.

2014-12-01

Feature layers in the National Map program (TNM) are a fundamental context for much of the data collection and analysis conducted by the USGS and other governmental and nongovernmental organizations. Their computational usefulness, though, has been constrained by the lack of formal relationships besides superposition between TNM layers, as well as limited means of representing how TNM datasets relate to additional attributes, datasets, and activities. In the field of Geospatial Information Science, there has been a growing recognition of the value of semantic representation and technology for addressing these limitations, particularly in the face of burgeoning information volume and heterogeneity. Fundamental to this approach is the development of formal ontologies for concepts related to that information that can be processed computationally to enhance creation and discovery of new geospatial knowledge. They offer a means of making much of the presently innate knowledge about relationships in and between TNM features accessible for machine processing and distributed computation.A full and comprehensive ontology of all knowledge represented by TNM features is still impractical. The work reported here involves elaboration and integration of a number of small ontology design patterns (ODP's) that represent limited, discrete, but commonly accepted and broadly applicable physical theories for the behavior of TNM features representing surface water bodies and landscape surfaces and the connections between them. These ontology components are validated through use in applications for discovery and aggregation of water science observational data associated with National Hydrography Data features, features from the National Elevation Dataset (NED) and Water Boundary Dataset (WBD) that constrain water occurrence in the continental US. These applications emphasize workflows which are difficult or impossible to automate using existing data structures. Evaluation of the usefulness of the developed ontology components includes both solicitation of feedback on prototype applications, and provision of a query / mediation service for feature-linked data to facilitate development of additional third-party applications.

20 CFR 408.624 - How do we investigate a representative payee applicant?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How do we investigate a representative payee applicant? 408.624 Section 408.624 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Representative Payment § 408.624 How do we investigate a representative...

20 CFR 408.624 - How do we investigate a representative payee applicant?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How do we investigate a representative payee applicant? 408.624 Section 408.624 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Representative Payment § 408.624 How do we investigate a representative...

20 CFR 408.624 - How do we investigate a representative payee applicant?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false How do we investigate a representative payee applicant? 408.624 Section 408.624 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Representative Payment § 408.624 How do we investigate a representative...

20 CFR 408.624 - How do we investigate a representative payee applicant?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false How do we investigate a representative payee applicant? 408.624 Section 408.624 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Representative Payment § 408.624 How do we investigate a representative...

20 CFR 408.624 - How do we investigate a representative payee applicant?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false How do we investigate a representative payee applicant? 408.624 Section 408.624 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Representative Payment § 408.624 How do we investigate a representative...

20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

Code of Federal Regulations, 2010 CFR

2010-04-01

... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

Code of Federal Regulations, 2013 CFR

2013-04-01

... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

Code of Federal Regulations, 2012 CFR

2012-04-01

... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

Code of Federal Regulations, 2014 CFR

2014-04-01

... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

20 CFR 266.6 - Information to be submitted by a representative payee-applicant; face-to-face interview.

Code of Federal Regulations, 2011 CFR

2011-04-01

... representative payee-applicant; face-to-face interview. 266.6 Section 266.6 Employees' Benefits RAILROAD... be submitted by a representative payee-applicant; face-to-face interview. Before the Board selects a... listed in § 266.4 of this part. An employee of the Board may also conduct a face-to-face interview with...

Plant Immunity Inducer Development and Application.

PubMed

Dewen, Qiu; Yijie, Dong; Yi, Zhang; Shupeng, Li; Fachao, Shi

2017-05-01

Plant immunity inducers represent a new and rapidly developing field in plant-protection research. In this paper, we discuss recent research on plant immunity inducers and their development and applications in China. Plant immunity inducers include plant immunity-inducing proteins, chitosan oligosaccharides, and microbial inducers. These compounds and microorganisms can trigger defense responses and confer disease resistance in plants. We also describe the mechanisms of plant immunity inducers and how they promote plant health. Furthermore, we summarize the current situation in plant immunity inducer development in China and the global marketplace. Finally, we also deeply analyze the development trends and application prospects of plant immunity inducers in environmental protection and food safety.

Multiphase Fluid Dynamics for Spacecraft Applications

NASA Astrophysics Data System (ADS)

Shyy, W.; Sim, J.

2011-09-01

Multiphase flows involving moving interfaces between different fluids/phases are observed in nature as well as in a wide range of engineering applications. With the recent development of high fidelity computational techniques, a number of challenging multiphase flow problems can now be computed. We introduce the basic notion of the main categories of multiphase flow computation; Lagrangian, Eulerian, and Eulerian-Lagrangian techniques to represent and follow interface, and sharp and continuous interface methods to model interfacial dynamics. The marker-based adaptive Eulerian-Lagrangian method, which is one of the most popular methods, is highlighted with microgravity and space applications including droplet collision and spacecraft liquid fuel tank surface stability.

Simulation by bondgraphs

NASA Astrophysics Data System (ADS)

Thoma, Jean Ulrich

The fundamental principles and applications of the bond graph method, in which a system is represented on paper by letter elements and their interconnections (bonds), are presented in an introduction for engineering students. Chapters are devoted to simulation and graphical system models; bond graphs as networks for power and signal exchange; the simulation and design of mechanical engineering systems; the simulation of fluid power systems and hydrostatic devices; electrical circuits, drives, and components; practical procedures and problems of bond-graph-based numerical simulation; and applications to thermodynamics, chemistry, and biology. Also included are worked examples of applications to robotics, shocks and collisions, ac circuits, hydraulics, and a hydropneumatic fatigue-testing machine.

Algorithms for Collision Detection Between a Point and a Moving Polygon, with Applications to Aircraft Weather Avoidance

NASA Technical Reports Server (NTRS)

Narkawicz, Anthony; Hagen, George

2016-01-01

This paper proposes mathematical definitions of functions that can be used to detect future collisions between a point and a moving polygon. The intended application is weather avoidance, where the given point represents an aircraft and bounding polygons are chosen to model regions with bad weather. Other applications could possibly include avoiding other moving obstacles. The motivation for the functions presented here is safety, and therefore they have been proved to be mathematically correct. The functions are being developed for inclusion in NASA's Stratway software tool, which allows low-fidelity air traffic management concepts to be easily prototyped and quickly tested.

Common spaceborne multicomputer operating system and development environment

NASA Technical Reports Server (NTRS)

Craymer, L. G.; Lewis, B. F.; Hayes, P. J.; Jones, R. L.

1994-01-01

A preliminary technical specification for a multicomputer operating system is developed. The operating system is targeted for spaceborne flight missions and provides a broad range of real-time functionality, dynamic remote code-patching capability, and system fault tolerance and long-term survivability features. Dataflow concepts are used for representing application algorithms. Functional features are included to ensure real-time predictability for a class of algorithms which require data-driven execution on an iterative steady state basis. The development environment supports the development of algorithm code, design of control parameters, performance analysis, simulation of real-time dataflow applications, and compiling and downloading of the resulting application.

Application of the Modular Command and Control Structure (MCES) to Marine Corps SINCGARS Allocation

DTIC Science & Technology

1991-07-01

The first goal is to delineate the difference between the system being analyzed and its environment . To bound the C3 system, the analyst should...hardware and software entities and structures, is related to the forces it controls and the environmental stimuli to which it responds, including the enemy...M CES represents the environmental facto:s that require explicit assumptions in the problem. This ring may be seen as including the major scenario

Space shuttle propulsion estimation development verification

NASA Technical Reports Server (NTRS)

Rogers, Robert M.

1989-01-01

The application of extended Kalman filtering to estimating the Space Shuttle Propulsion performance, i.e., specific impulse, from flight data in a post-flight processing computer program is detailed. The flight data used include inertial platform acceleration, SRB head pressure, SSME chamber pressure and flow rates, and ground based radar tracking data. The key feature in this application is the model used for the SRB's, which is a nominal or reference quasi-static internal ballistics model normalized to the propellant burn depth. Dynamic states of mass overboard and propellant burn depth are included in the filter model to account for real-time deviations from the reference model used. Aerodynamic, plume, wind and main engine uncertainties are also included for an integrated system model. Assuming uncertainty within the propulsion system model and attempts to estimate its deviations represent a new application of parameter estimation for rocket powered vehicles. Illustrations from the results of applying this estimation approach to several missions show good quality propulsion estimates.

New fundamental parameters for attitude representation

NASA Astrophysics Data System (ADS)

Patera, Russell P.

2017-08-01

A new attitude parameter set is developed to clarify the geometry of combining finite rotations in a rotational sequence and in combining infinitesimal angular increments generated by angular rate. The resulting parameter set of six Pivot Parameters represents a rotation as a great circle arc on a unit sphere that can be located at any clocking location in the rotation plane. Two rotations are combined by linking their arcs at either of the two intersection points of the respective rotation planes. In a similar fashion, linking rotational increments produced by angular rate is used to derive the associated kinematical equations, which are linear and have no singularities. Included in this paper is the derivation of twelve Pivot Parameter elements that represent all twelve Euler Angle sequences, which enables efficient conversions between Pivot Parameters and any Euler Angle sequence. Applications of this new parameter set include the derivation of quaternions and the quaternion composition rule, as well as, the derivation of the analytical solution to time dependent coning motion. The relationships between Pivot Parameters and traditional parameter sets are included in this work. Pivot Parameters are well suited for a variety of aerospace applications due to their effective composition rule, singularity free kinematic equations, efficient conversion to and from Euler Angle sequences and clarity of their geometrical foundation.

Color Image Processing and Object Tracking System

NASA Technical Reports Server (NTRS)

Klimek, Robert B.; Wright, Ted W.; Sielken, Robert S.

1996-01-01

This report describes a personal computer based system for automatic and semiautomatic tracking of objects on film or video tape, developed to meet the needs of the Microgravity Combustion and Fluids Science Research Programs at the NASA Lewis Research Center. The system consists of individual hardware components working under computer control to achieve a high degree of automation. The most important hardware components include 16-mm and 35-mm film transports, a high resolution digital camera mounted on a x-y-z micro-positioning stage, an S-VHS tapedeck, an Hi8 tapedeck, video laserdisk, and a framegrabber. All of the image input devices are remotely controlled by a computer. Software was developed to integrate the overall operation of the system including device frame incrementation, grabbing of image frames, image processing of the object's neighborhood, locating the position of the object being tracked, and storing the coordinates in a file. This process is performed repeatedly until the last frame is reached. Several different tracking methods are supported. To illustrate the process, two representative applications of the system are described. These applications represent typical uses of the system and include tracking the propagation of a flame front and tracking the movement of a liquid-gas interface with extremely poor visibility.

17 CFR 210.12-23 - Mortgage loans on real estate and interest earned on mortgages. 1

Code of Federal Regulations, 2014 CFR

2014-04-01

... business (total) Unimproved (total) Total 12 1 All money columns shall be totaled. 2 If mortgages represent... profit and loss or income statement, interest income earned applicable to period from mortgages sold or... column C includes intercompany profits, state the bases of the transactions resulting in such profits and...

40 CFR 420.12 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... for by-product coke plants which have wet desulfurization systems but only to the extent such systems... limitations, are allowed for by-product coke plants which include indirect ammonia recovery systems but only..., are allowed for by-product coke plants which have wet desulfurization systems but only to the extent...

40 CFR 420.17 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... loadings, not to exceed 11 percent of the above limitations, are allowed for by-product coke plants which...-product coke plants which include indirect ammonia recovery systems but only to the extent that such... allowed for by-product coke plants which have wet desulfurization systems but only to the extent such...

40 CFR 420.17 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2014 CFR

2014-07-01

... loadings, not to exceed 11 percent of the above limitations, are allowed for by-product coke plants which...-product coke plants which include indirect ammonia recovery systems but only to the extent that such... allowed for by-product coke plants which have wet desulfurization systems but only to the extent such...

40 CFR 420.17 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... loadings, not to exceed 11 percent of the above limitations, are allowed for by-product coke plants which...-product coke plants which include indirect ammonia recovery systems but only to the extent that such... allowed for by-product coke plants which have wet desulfurization systems but only to the extent such...

40 CFR 420.12 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2014 CFR

2014-07-01

... for by-product coke plants which have wet desulfurization systems but only to the extent such systems... limitations, are allowed for by-product coke plants which include indirect ammonia recovery systems but only..., are allowed for by-product coke plants which have wet desulfurization systems but only to the extent...

40 CFR 420.12 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... for by-product coke plants which have wet desulfurization systems but only to the extent such systems... limitations, are allowed for by-product coke plants which include indirect ammonia recovery systems but only..., are allowed for by-product coke plants which have wet desulfurization systems but only to the extent...

40 CFR 420.17 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... loadings, not to exceed 11 percent of the above limitations, are allowed for by-product coke plants which...-product coke plants which include indirect ammonia recovery systems but only to the extent that such... allowed for by-product coke plants which have wet desulfurization systems but only to the extent such...

40 CFR 420.12 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... for by-product coke plants which have wet desulfurization systems but only to the extent such systems... limitations, are allowed for by-product coke plants which include indirect ammonia recovery systems but only..., are allowed for by-product coke plants which have wet desulfurization systems but only to the extent...

Wavelet Transforms in Parallel Image Processing

DTIC Science & Technology

1994-01-27

NUMBER OF PAGES Object Segmentation, Texture Segmentation, Image Compression, Image 137 Halftoning , Neural Network, Parallel Algorithms, 2D and 3D...Vector Quantization of Wavelet Transform Coefficients ........ ............................. 57 B.1.f Adaptive Image Halftoning based on Wavelet...application has been directed to the adaptive image halftoning . The gray information at a pixel, including its gray value and gradient, is represented by

National Educational Computing Conference Proceedings (9th, Dallas, Texas, June 15-17, 1988).

ERIC Educational Resources Information Center

Ryan, William C., Ed.

The more than 200 papers and panel, project, and special session reports represented in this collection focus on innovations, trends, and research on the use of computers in a variety of educational settings. Of these, the full text is provided for 37 presentations and abstracts for 182. The topics discussed include: computer applications in…

High Technology Product Training for Sales Representatives of Spectrum Healthcare Solutions and International Business Machines Corporation.

ERIC Educational Resources Information Center

Crystal, Enid

This report describes an application of the Instructional Systems Design (ISD) process to a product knowledge training project for Spectrum Healthcare Solutions, Inc., including the steps and substeps in the phases of analysis, design, development, implementation, and evaluation. The training project was designed to address the need for increased…

40 CFR 440.33 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

...) The concentration of pollutants discharged in mine drainage from mines, either open-pit or underground, that produce uranium ore, including mines using in-situ leach methods, shall not exceed: Effluent...). Except as provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing point source...

40 CFR 440.32 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... using in-situ leach methods shall not exceed: Effluent characteristic Effluent limitations Maximum for... uranium, radium and vanadium including mill-mine facilities and mines using in-situ leach methods shall... available (BPT). Except as provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing...

40 CFR 440.33 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... concentration of pollutants discharged in mine drainage from mines, either open-pit or underground, that produce uranium ore, including mines using in-situ leach methods, shall not exceed: Effluent characteristic... provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing point source subject to...

40 CFR 440.32 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2014 CFR

2014-07-01

... using in-situ leach methods shall not exceed: Effluent characteristic Effluent limitations Maximum for... uranium, radium and vanadium including mill-mine facilities and mines using in-situ leach methods shall... available (BPT). Except as provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing...

40 CFR 440.33 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2014 CFR

2014-07-01

...) The concentration of pollutants discharged in mine drainage from mines, either open-pit or underground, that produce uranium ore, including mines using in-situ leach methods, shall not exceed: Effluent...). Except as provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing point source...

40 CFR 440.33 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... concentration of pollutants discharged in mine drainage from mines, either open-pit or underground, that produce uranium ore, including mines using in-situ leach methods, shall not exceed: Effluent characteristic... provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing point source subject to...

40 CFR 440.32 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... using in-situ leach methods shall not exceed: Effluent characteristic Effluent limitations Maximum for... uranium, radium and vanadium including mill-mine facilities and mines using in-situ leach methods shall... available (BPT). Except as provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing...

Towards a system level understanding of non-model organisms sampled from the environment: a network biology approach.

PubMed

Williams, Tim D; Turan, Nil; Diab, Amer M; Wu, Huifeng; Mackenzie, Carolynn; Bartie, Katie L; Hrydziuszko, Olga; Lyons, Brett P; Stentiford, Grant D; Herbert, John M; Abraham, Joseph K; Katsiadaki, Ioanna; Leaver, Michael J; Taggart, John B; George, Stephen G; Viant, Mark R; Chipman, Kevin J; Falciani, Francesco

2011-08-01

The acquisition and analysis of datasets including multi-level omics and physiology from non-model species, sampled from field populations, is a formidable challenge, which so far has prevented the application of systems biology approaches. If successful, these could contribute enormously to improving our understanding of how populations of living organisms adapt to environmental stressors relating to, for example, pollution and climate. Here we describe the first application of a network inference approach integrating transcriptional, metabolic and phenotypic information representative of wild populations of the European flounder fish, sampled at seven estuarine locations in northern Europe with different degrees and profiles of chemical contaminants. We identified network modules, whose activity was predictive of environmental exposure and represented a link between molecular and morphometric indices. These sub-networks represented both known and candidate novel adverse outcome pathways representative of several aspects of human liver pathophysiology such as liver hyperplasia, fibrosis, and hepatocellular carcinoma. At the molecular level these pathways were linked to TNF alpha, TGF beta, PDGF, AGT and VEGF signalling. More generally, this pioneering study has important implications as it can be applied to model molecular mechanisms of compensatory adaptation to a wide range of scenarios in wild populations.

Towards a System Level Understanding of Non-Model Organisms Sampled from the Environment: A Network Biology Approach

PubMed Central

Williams, Tim D.; Turan, Nil; Diab, Amer M.; Wu, Huifeng; Mackenzie, Carolynn; Bartie, Katie L.; Hrydziuszko, Olga; Lyons, Brett P.; Stentiford, Grant D.; Herbert, John M.; Abraham, Joseph K.; Katsiadaki, Ioanna; Leaver, Michael J.; Taggart, John B.; George, Stephen G.; Viant, Mark R.; Chipman, Kevin J.; Falciani, Francesco

2011-01-01

The acquisition and analysis of datasets including multi-level omics and physiology from non-model species, sampled from field populations, is a formidable challenge, which so far has prevented the application of systems biology approaches. If successful, these could contribute enormously to improving our understanding of how populations of living organisms adapt to environmental stressors relating to, for example, pollution and climate. Here we describe the first application of a network inference approach integrating transcriptional, metabolic and phenotypic information representative of wild populations of the European flounder fish, sampled at seven estuarine locations in northern Europe with different degrees and profiles of chemical contaminants. We identified network modules, whose activity was predictive of environmental exposure and represented a link between molecular and morphometric indices. These sub-networks represented both known and candidate novel adverse outcome pathways representative of several aspects of human liver pathophysiology such as liver hyperplasia, fibrosis, and hepatocellular carcinoma. At the molecular level these pathways were linked to TNF alpha, TGF beta, PDGF, AGT and VEGF signalling. More generally, this pioneering study has important implications as it can be applied to model molecular mechanisms of compensatory adaptation to a wide range of scenarios in wild populations. PMID:21901081

7 CFR 1944.660 - Authorized representative of the HPG applicant and FmHA or its successor agency under Public Law...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 13 2011-01-01 2009-01-01 true Authorized representative of the HPG applicant and Fm... of the HPG applicant and FmHA or its successor agency under Public Law 103-354 point of contact. (a) FmHA or its successor agency under Public Law 103-354 will deal only with authorized representatives...

7 CFR 1944.660 - Authorized representative of the HPG applicant and FmHA or its successor agency under Public Law...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Authorized representative of the HPG applicant and Fm... of the HPG applicant and FmHA or its successor agency under Public Law 103-354 point of contact. (a) FmHA or its successor agency under Public Law 103-354 will deal only with authorized representatives...

Application of Solar-Electric Propulsion to Robotic and Human Missions in Near-Earth Space

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Dankanich, John

2011-01-01

Interest in applications of solar electric propulsion (SEP) is increasing. Application of SEP technology is favored when: (1) the mission is compatible with low-thrust propulsion, (2) the mission needs high total delta V such that chemical propulsion is disadvantaged; and (3) performance enhancement is needed. If all such opportunities for future missions are considered, many uses of SEP are likely. Representative missions are surveyed and several SEP applications selected for analysis, including orbit raising, lunar science, lunar exploration, lunar exploitation, planetary science, and planetary exploration. These missions span SEP power range from 10s of kWe to several MWe. Modes of use and benefits are described, and potential SEP evolution is discussed.

Application of Solar-Electric Propulsion to Robotic and Human Missions in Near-Earth Space

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Dankanich, John

2006-01-01

Interest in applications of solar electric propulsion (SEP) is increasing. Application of SEP technology is favored when: (1) the mission is compatible with low-thrust propulsion, (2) the mission needs high total delta V such that chemical propulsion is disadvantaged; and (3) performance enhancement is needed. If all such opportunities for future missions are considered, many uses of SEP are likely. Representative missions are surveyed and several SEP applications selected for analysis, including orbit raising, lunar science, lunar exploration, lunar exploitation, planetary science, and planetary exploration. These missions span SEP power range from 10s of kWe to several MWe. Modes of use and benefits are described, and potential SEP evolution is discussed.

NASA GSFC Strategic Nanotechnology Interests: Symposium on High-Rate Nanoscale Printing for Devices and Structures

NASA Technical Reports Server (NTRS)

Ericsson, Aprille J.

2014-01-01

The seminars invitees include representatives from industry, nonprofit research facility and universities. The presentation provides an overview of the NASAGSFC locations, technical capabilities and applied nanotechnology interests. Initially presented are advances by the broader technological communities on current miniaturized multiscale advanced manufacturing and 3D printing products on the micro and macro scale. Briefly assessed is the potential of moving toward the nanoscale for possible space flight applications and challenges. Lastly, highlighted are GSFCs current successes in nano-technology developments and targeted future applications.

FGRAAL: FORTRAN extended graph algorithmic language

NASA Technical Reports Server (NTRS)

Basili, V. R.; Mesztenyi, C. K.; Rheinboldt, W. C.

1972-01-01

The FORTRAN version FGRAAL of the graph algorithmic language GRAAL as it has been implemented for the Univac 1108 is described. FBRAAL is an extension of FORTRAN 5 and is intended for describing and implementing graph algorithms of the type primarily arising in applications. The formal description contained in this report represents a supplement to the FORTRAN 5 manual for the Univac 1108 (UP-4060), that is, only the new features of the language are described. Several typical graph algorithms, written in FGRAAL, are included to illustrate various features of the language and to show its applicability.

Pervasive Sensing: Addressing the Heterogeneity Problem

NASA Astrophysics Data System (ADS)

O'Grady, Michael J.; Murdoch, Olga; Kroon, Barnard; Lillis, David; Carr, Dominic; Collier, Rem W.; O'Hare, Gregory M. P.

2013-06-01

Pervasive sensing is characterized by heterogeneity across a number of dimensions. This raises significant problems for those designing, implementing and deploying sensor networks, irrespective of application domain. Such problems include for example, issues of data provenance and integrity, security, and privacy amongst others. Thus engineering a network that is fit-for-purpose represents a significant challenge. In this paper, the issue of heterogeneity is explored from the perspective of those who seek to harness a pervasive sensing element in their applications. A initial solution is proposed based on the middleware construct.

40 CFR 430.114 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... degree of effluent reduction attainable by the application of the best available technology economically... effluent reduction attainable by the application of the best available technology economically achievable... representing the degree of effluent reduction attainable by the application of the best available technology...

40 CFR 430.114 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... degree of effluent reduction attainable by the application of the best available technology economically... effluent reduction attainable by the application of the best available technology economically achievable... representing the degree of effluent reduction attainable by the application of the best available technology...

Quantifying the visual appearance of sunscreens applied to the skin using indirect computer image colorimetry.

PubMed

Richer, Vincent; Kharazmi, Pegah; Lee, Tim K; Kalia, Sunil; Lui, Harvey

2018-03-01

There is no accepted method to objectively assess the visual appearance of sunscreens on the skin. We present a method for sunscreen application, digital photography, and computer analysis to quantify the appearance of the skin after sunscreen application. Four sunscreen lotions were applied randomly at densities of 0.5, 1.0, 1.5, and 2.0 mg/cm 2 to areas of the back of 29 subjects. Each application site had a matched contralateral control area. High-resolution standardized photographs including a color card were taken after sunscreen application. After color balance correction, CIE L*a*b* color values were extracted from paired sites. Differences in skin appearance attributed to sunscreen were represented by ΔE, which in turn was calculated from the linear Euclidean distance within the L*a*b* color space between the paired sites. Sunscreen visibility as measured by median ΔE varied across different products and application densities and ranged between 1.2 and 12.1. The visibility of sunscreens varied according to product SPF, composition (organic vs inorganic), presence of tint, and baseline b* of skin (P < .05 for all). Standardized sunscreen application followed by digital photography and indirect computer-based colorimetry represents a potential method to objectively quantify visibility of sunscreen on the skin. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

FG90 chitosan as a new polymer for metronidazole mucoadhesive tablets for vaginal administration.

PubMed

Perioli, Luana; Ambrogi, Valeria; Pagano, Cinzia; Scuota, Stefania; Rossi, Carlo

2009-07-30

Topical administration of the antibacterial metronidazole (MET) represents the most common therapy in the treatment of bacterial vaginosis (BV). The formulations generally available for BV therapy are creams, gels, vaginal lavages and vaginal suppositories. In this study, a new dosage form, containing MET, was developed with the aim to realize vaginal mucoadhesive tablets by including bioadhesive polymers as chitosan (FG90C), polyvinylpyrrolidone (PVPK90) and polycarbophil (PCPAA1), blended in different ratios. All formulations were characterized by studies of DSC, friability, hardness, hydration, mucoadhesion, in vitro release and antibacterial activity. All polymer mixtures employed were used to prepare tablets with the compactness and hardness so as allow the application on vaginal mucosa. FG90C performances improved in particular when mixed to PVPK90 (1:1 ratio). This kind of delivery system is suitable for formulating MET for topical application representing a good alternative to traditional dosage forms for vaginal topical administration.

John Lumley's Contributions to Turbulence Modeling

NASA Astrophysics Data System (ADS)

Pope, Stephen

2015-11-01

We recall the contributions that John Lumley made to turbulence modeling in the 1970s and 1980s. In these early days, computer power was feeble by today's standards, and eddy-viscosity models were prevalent in CFD. Lumley recognized, however, that second-moment closures represent the simplest level at which the physics of turbulent flows can reasonably be represented. This is especially true when the velocity field is coupled to scalar fields through buoyancy, as in the atmosphere and oceans. While Lumley was not the first to propose second-moment closures, he can be credited with establishing the rational approach to constructing such closures. This includes the application of various invariance principles and tensor representation theorems, imposing the constraints imposed by realizability, and of course appealing to experimental data in simple, canonical flows. These techniques are now well-accepted and have found application far beyond second-moment closures.

Assessing the role of mini-applications in predicting key performance characteristics of scientific and engineering applications

DOE PAGES

Barrett, R. F.; Crozier, P. S.; Doerfler, D. W.; ...

2014-09-28

Computational science and engineering application programs are typically large, complex, and dynamic, and are often constrained by distribution limitations. As a means of making tractable rapid explorations of scientific and engineering application programs in the context of new, emerging, and future computing architectures, a suite of miniapps has been created to serve as proxies for full scale applications. Each miniapp is designed to represent a key performance characteristic that does or is expected to significantly impact the runtime performance of an application program. In this paper we introduce a methodology for assessing the ability of these miniapps to effectively representmore » these performance issues. We applied this methodology to four miniapps, examining the linkage between them and an application they are intended to represent. Herein we evaluate the fidelity of that linkage. This work represents the initial steps required to begin to answer the question, ''Under what conditions does a miniapp represent a key performance characteristic in a full app?''« less

Seismic signal processing on heterogeneous supercomputers

NASA Astrophysics Data System (ADS)

Gokhberg, Alexey; Ermert, Laura; Fichtner, Andreas

2015-04-01

The processing of seismic signals - including the correlation of massive ambient noise data sets - represents an important part of a wide range of seismological applications. It is characterized by large data volumes as well as high computational input/output intensity. Development of efficient approaches towards seismic signal processing on emerging high performance computing systems is therefore essential. Heterogeneous supercomputing systems introduced in the recent years provide numerous computing nodes interconnected via high throughput networks, every node containing a mix of processing elements of different architectures, like several sequential processor cores and one or a few graphical processing units (GPU) serving as accelerators. A typical representative of such computing systems is "Piz Daint", a supercomputer of the Cray XC 30 family operated by the Swiss National Supercomputing Center (CSCS), which we used in this research. Heterogeneous supercomputers provide an opportunity for manifold application performance increase and are more energy-efficient, however they have much higher hardware complexity and are therefore much more difficult to program. The programming effort may be substantially reduced by the introduction of modular libraries of software components that can be reused for a wide class of seismology applications. The ultimate goal of this research is design of a prototype for such library suitable for implementing various seismic signal processing applications on heterogeneous systems. As a representative use case we have chosen an ambient noise correlation application. Ambient noise interferometry has developed into one of the most powerful tools to image and monitor the Earth's interior. Future applications will require the extraction of increasingly small details from noise recordings. To meet this demand, more advanced correlation techniques combined with very large data volumes are needed. This poses new computational problems that require dedicated HPC solutions. The chosen application is using a wide range of common signal processing methods, which include various IIR filter designs, amplitude and phase correlation, computing the analytic signal, and discrete Fourier transforms. Furthermore, various processing methods specific for seismology, like rotation of seismic traces, are used. Efficient implementation of all these methods on the GPU-accelerated systems represents several challenges. In particular, it requires a careful distribution of work between the sequential processors and accelerators. Furthermore, since the application is designed to process very large volumes of data, special attention had to be paid to the efficient use of the available memory and networking hardware resources in order to reduce intensity of data input and output. In our contribution we will explain the software architecture as well as principal engineering decisions used to address these challenges. We will also describe the programming model based on C++ and CUDA that we used to develop the software. Finally, we will demonstrate performance improvements achieved by using the heterogeneous computing architecture. This work was supported by a grant from the Swiss National Supercomputing Centre (CSCS) under project ID d26.

Advanced techniques and technology for efficient data storage, access, and transfer

NASA Technical Reports Server (NTRS)

Rice, Robert F.; Miller, Warner

1991-01-01

Advanced techniques for efficiently representing most forms of data are being implemented in practical hardware and software form through the joint efforts of three NASA centers. These techniques adapt to local statistical variations to continually provide near optimum code efficiency when representing data without error. Demonstrated in several earlier space applications, these techniques are the basis of initial NASA data compression standards specifications. Since the techniques clearly apply to most NASA science data, NASA invested in the development of both hardware and software implementations for general use. This investment includes high-speed single-chip very large scale integration (VLSI) coding and decoding modules as well as machine-transferrable software routines. The hardware chips were tested in the laboratory at data rates as high as 700 Mbits/s. A coding module's definition includes a predictive preprocessing stage and a powerful adaptive coding stage. The function of the preprocessor is to optimally process incoming data into a standard form data source that the second stage can handle.The built-in preprocessor of the VLSI coder chips is ideal for high-speed sampled data applications such as imaging and high-quality audio, but additionally, the second stage adaptive coder can be used separately with any source that can be externally preprocessed into the 'standard form'. This generic functionality assures that the applicability of these techniques and their recent high-speed implementations should be equally broad outside of NASA.

Mobile Applications for Diabetes Self-Management: Status and Potential

PubMed Central

El-Gayar, Omar; Timsina, Prem; Nawar, Nevine; Eid, Wael

2013-01-01

Background Advancements in smartphone technology coupled with the proliferation of data connectivity has resulted in increased interest and unprecedented growth in mobile applications for diabetes self-management. The objective of this article is to determine, in a systematic review, whether diabetes applications have been helping patients with type 1 or type 2 diabetes self-manage their condition and to identify issues necessary for large-scale adoption of such interventions. Methods The review covers commercial applications available on the Apple App Store (as a representative of commercially available applications) and articles published in relevant databases covering a period from January 1995 to August 2012. The review included all applications supporting any diabetes self-management task where the patient is the primary actor. Results Available applications support self-management tasks such as physical exercise, insulin dosage or medication, blood glucose testing, and diet. Other support tasks considered include decision support, notification/alert, tagging of input data, and integration with social media. The review points to the potential for mobile applications to have a positive impact on diabetes self-management. Analysis indicates that application usage is associated with improved attitudes favorable to diabetes self-management. Limitations of the applications include lack of personalized feedback; usability issues, particularly the ease of data entry; and integration with patients and electronic health records. Conclusions Research into the adoption and use of user-centered and sociotechnical design principles is needed to improve usability, perceived usefulness, and, ultimately, adoption of the technology. Proliferation and efficacy of interventions involving mobile applications will benefit from a holistic approach that takes into account patients’ expectations and providers’ needs. PMID:23439183

The 1987 Goddard Space Flight Center Battery Workshop

NASA Technical Reports Server (NTRS)

Morrow, George (Editor); Yi, Thomas Y. (Editor)

1993-01-01

This document contains the proceedings of the 20th annual Battery Workshop held at Goddard Space Flight Center, Greenbelt, Maryland on November 4-5, 1987. The workshop attendees included manufacturers, users, and government representatives interested in the latest developments in battery technology as they relate to high reliability operations and aerospace use. The subjects covered included lithium cell technology and safety improvements, nickel-cadmium electrode technology along with associated modifications, flight experience and life testing of nickel-cadmium cells, and nickel-hydrogen applications and technology.

Comparisons of rational engineering correlations of thermophoretically-augmented particle mass transfer with STAN5-predictions for developing boundary layers

NASA Technical Reports Server (NTRS)

Gokoglu, S. A.; Rosner, D. E.

1984-01-01

Modification of the code STAN5 to properly include thermophoretic mass transport, and examination of selected test cases developing boundary layers which include variable properties, viscous dissipation, transition to turbulence and transpiration cooling. Under conditions representative of current and projected GT operation, local application of St(M)/St(M),o correlations evidently provides accurate and economical engineering design predictions, especially for suspended particles characterized by Schmidt numbers outside of the heavy vapor range.

40 CFR 445.13 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... limitations which represent the application of BAT: Limitations for ammonia (as N), a-terpineol, aniline... degree of effluent reduction attainable by the application of best available technology economically... application of best available technology economically achievable (BAT). Except as provided in 40 CFR 125.30...

Non-Relative Value Unit-Generating Activities Represent One-Fifth of Academic Neuroradiologist Productivity.

PubMed

Wintermark, M; Zeineh, M; Zaharchuk, G; Srivastava, A; Fischbein, N

2016-07-01

A neuroradiologist's activity includes many tasks beyond interpreting relative value unit-generating imaging studies. Our aim was to test a simple method to record and quantify the non-relative value unit-generating clinical activity represented by consults and clinical conferences, including tumor boards. Four full-time neuroradiologists, working an average of 50% clinical and 50% academic activity, systematically recorded all the non-relative value unit-generating consults and conferences in which they were involved during 3 months by using a simple, Web-based, computer-based application accessible from smartphones, tablets, or computers. The number and type of imaging studies they interpreted during the same period and the associated relative value units were extracted from our billing system. During 3 months, the 4 neuroradiologists working an average of 50% clinical activity interpreted 4241 relative value unit-generating imaging studies, representing 8152 work relative value units. During the same period, they recorded 792 non-relative value unit-generating study reviews as part of consults and conferences (not including reading room consults), representing 19% of the interpreted relative value unit-generating imaging studies. We propose a simple Web-based smartphone app to record and quantify non-relative value unit-generating activities including consults, clinical conferences, and tumor boards. The quantification of non-relative value unit-generating activities is paramount in this time of a paradigm shift from volume to value. It also represents an important tool for determining staffing levels, which cannot be performed on the basis of relative value unit only, considering the importance of time spent by radiologists on non-relative value unit-generating activities. It may also influence payment models from medical centers to radiology departments or practices. © 2016 by American Journal of Neuroradiology.

Monitored Natural Attenuation of Inorganic Contaminants in Ground Water Volume 3 Assessment for Radionuclides IncludingTritium, Radon, Strontium, Technetium, Uranium, Iodine, Radium, Thorium, Cesium, and Plutonium-Americium

EPA Science Inventory

The current document represents the third volume of a set of three volumes that address the technical basis and requirements for assessing the potential applicability of MNA as part of a ground-water remedy for plumes with nonradionuclide and/or radionuclide inorganic contamina...

Monitored Attenuation of Inorganic Contaminants in Ground Water Volume 2 – Assessment for Non-Radionuclides Including Arsenic, Cadmium, Chromium, Copper, Lead, Nickel, Nitrate, Perchlorate, and Selenium

EPA Science Inventory

This document represents the second volume of a set of three volumes that address the technical basis and requirements for assessing the potential applicability of MNA as part of a ground-water remedy for plumes with non-radionuclide and/or radionuclide inorganic contaminants. V...

The combined application of the Caco-2 cell bioassay coupled with in vivo (Gallus gallus) feeding trial represents an effective approach to predicting Fe bioavailability in humans

USDA-ARS?s Scientific Manuscript database

Research methods that predict Fe bioavailability for humans can be extremely useful in evaluating food fortification strategies, developing Fe-biofortified enhanced staple food crops and assessing the Fe bioavailability of meal plans that include such crops. In this review, research from four recent...

76 FR 62058 - AmerenUE; Notice of Application for Amendment of License, and Soliciting Comments, Motions To...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... the eComment system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name and... with proposed modifications. The proposal would provide an additional 110 boat slips and 32 personal watercraft (PWC) lifts to the facility. The expanded facility would represent a total of 14 docks, 232 boat...

Exploring the Effects of Congruence and Holland's Personality Codes on Job Satisfaction: An Application of Hierarchical Linear Modeling Techniques

ERIC Educational Resources Information Center

Ishitani, Terry T.

2010-01-01

This study applied hierarchical linear modeling to investigate the effect of congruence on intrinsic and extrinsic aspects of job satisfaction. Particular focus was given to differences in job satisfaction by gender and by Holland's first-letter codes. The study sample included nationally represented 1462 female and 1280 male college graduates who…

40 CFR 440.32 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., radium and vanadium including mill-mine facilities and mines using in-situ leach methods shall not exceed...). Except as provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing point source... available (BPT): (a) The concentration of pollutants discharged in mine drainage from mines, either open-pit...

40 CFR 440.32 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

..., radium and vanadium including mill-mine facilities and mines using in-situ leach methods shall not exceed...). Except as provided in subpart L of this part and 40 CFR 125.30 through 125.32, any existing point source... available (BPT): (a) The concentration of pollutants discharged in mine drainage from mines, either open-pit...

A study of the role of pyrotechnic systems on the space shuttle program

NASA Technical Reports Server (NTRS)

Lake, E. R.; Thompson, S. J.; Drexelius, V. W.

1973-01-01

Pyrotechnic systems, high burn rate propellant and explosive-actuated mechanisms, have been used extensively in aerospace vehicles to perform a variety of work functions, including crew escape, staging, deployment and destruction. Pyrotechnic system principles are described in this report along with their applications on typical military fighter aircraft, Mercury, Gemini, Apollo, and a representative unmanned spacecraft. To consider the possible pyrotechnic applications on the space shuttle the mechanical functions on a large commercial aircraft, similar in scale to the shuttle orbiter, were reviewed. Many potential applications exist for pyrotechnic system on the space shuttle, both in conventional short-duration functions and in longer duration and/or repetitive type gas generators.

The Earth Resources Laboratory Applications Software (ELAS) in university research and education: An operator oriented geobased information system

NASA Technical Reports Server (NTRS)

Coker, B. L.; Kind, T. C.; Smith, W. F., Jr.; Weber, N. V.

1981-01-01

Created for analyzing and processing digital data such as that collected by multispectral scanners or digitized from maps, ELAS is designed for ease of user operation and includes its own FORTRAN operating monitor and an expandable set of application modules which are FORTRAN overlays. On those machines that do not support FORTRAN overlaying, the modules exist as subprograms. The subsystem can be implemented on most 16-bit or 32-bit machines and is capable of, but not limited to, operating on low-cost minicomputer systems. The recommended hardware configuration for ELAS and a representative listing of some operating and application modules are presented.

Cohort Selection and Management Application Leveraging Standards-based Semantic Interoperability and a Groovy DSL

PubMed Central

Bucur, Anca; van Leeuwen, Jasper; Chen, Njin-Zu; Claerhout, Brecht; de Schepper, Kristof; Perez-Rey, David; Paraiso-Medina, Sergio; Alonso-Calvo, Raul; Mehta, Keyur; Krykwinski, Cyril

2016-01-01

This paper describes a new Cohort Selection application implemented to support streamlining the definition phase of multi-centric clinical research in oncology. Our approach aims at both ease of use and precision in defining the selection filters expressing the characteristics of the desired population. The application leverages our standards-based Semantic Interoperability Solution and a Groovy DSL to provide high expressiveness in the definition of filters and flexibility in their composition into complex selection graphs including splits and merges. Widely-adopted ontologies such as SNOMED-CT are used to represent the semantics of the data and to express concepts in the application filters, facilitating data sharing and collaboration on joint research questions in large communities of clinical users. The application supports patient data exploration and efficient collaboration in multi-site, heterogeneous and distributed data environments. PMID:27570644

40 CFR 424.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS FERROALLOY MANUFACTURING POINT SOURCE CATEGORY Open Electric... representing the degree of effluent reduction attainable by the application of the best available technology...

40 CFR 458.23 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... Thermal Process Subcategory § 458.23 Effluent limitations guidelines representing the degree of effluent reduction attainable by the application of the best available technology economically achievable. The...

40 CFR 458.33 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... Channel Process Subcategory § 458.33 Effluent limitations guidelines representing the degree of effluent reduction attainable by the application of the best available technology economically achievable. The...

40 CFR 458.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... Furnace Process Subcategory § 458.13 Effluent limitations guidelines representing the degree of effluent reduction attainable by the application of the best available technology economically achievable. The...

40 CFR 434.43 - Effluent limitations guidelines representing the degree of effluent reduction attainable by...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by application of the best available technology... NEW SOURCE PERFORMANCE STANDARDS Alkaline Mine Drainage § 434.43 Effluent limitations guidelines representing the degree of effluent reduction attainable by application of the best available technology...

40 CFR 434.43 - Effluent limitations guidelines representing the degree of effluent reduction attainable by...

Code of Federal Regulations, 2011 CFR

2011-07-01

... representing the degree of effluent reduction attainable by application of the best available technology... NEW SOURCE PERFORMANCE STANDARDS Alkaline Mine Drainage § 434.43 Effluent limitations guidelines representing the degree of effluent reduction attainable by application of the best available technology...

40 CFR 424.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS FERROALLOY MANUFACTURING POINT SOURCE CATEGORY Open Electric... representing the degree of effluent reduction attainable by the application of the best available technology...

40 CFR 424.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS FERROALLOY MANUFACTURING POINT SOURCE CATEGORY Open Electric... representing the degree of effluent reduction attainable by the application of the best available technology...

40 CFR 424.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS FERROALLOY MANUFACTURING POINT SOURCE CATEGORY Open Electric... representing the degree of effluent reduction attainable by the application of the best available technology...

40 CFR 424.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS FERROALLOY MANUFACTURING POINT SOURCE CATEGORY Open Electric... representing the degree of effluent reduction attainable by the application of the best available technology...

Addictive Disorders in Adolescents.

PubMed

Truong, Anh; Moukaddam, Nidal; Toledo, Alexander; Onigu-Otite, Edore

2017-09-01

Addictive disorders in youth represent a dynamic field characterized by shifting patterns of substance use and high rates of experimentation, while retaining the risky behaviors and negative outcomes associated with established drug classes. Youth/adolescents are also at the forefront of use of new technologies, and non-substance-related disorders are pertinent. These disorders present with similar pictures of impairment, and can be diagnosed following the same principles. An underlying mental disorder and the possibility of a dual diagnosis need to be assessed carefully, and optimal treatment includes psychosocial treatments with applicable pharmacologic management, the latter representing an expanding field. Copyright © 2017 Elsevier Inc. All rights reserved.

What has traditional Chinese medicine delivered for modern medicine?

PubMed

Wang, Jigang; Wong, Yin-Kwan; Liao, Fulong

2018-05-11

The field of Traditional Chinese Medicine (TCM) represents a vast and largely untapped resource for modern medicine. Exemplified by the success of the antimalarial artemisinin, the recent years have seen a rapid increase in the understanding and application of TCM-derived herbs and formulations for evidence-based therapy. In this review, we summarise and discuss the developmental history, clinical background and molecular basis of an action for several representative TCM-derived medicines, including artemisinin, arsenic trioxide, berberine and Salvia miltiorrhiza or Danshen. Through this, we highlight important examples of how TCM-derived medicines have already contributed to modern medicine, and discuss potential avenues for further research.

Application of Solar-Electric Propulsion to Robotic Missions in Near-Earth Space

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Dankanich, John

2007-01-01

Interest in applications of solar electric propulsion (SEP) is increasing. Application of SEP technology is favored when: (1) the mission is compatible with low-thrust propulsion, (2) the mission needs high total delta V such that chemical propulsion is disadvantaged; and (3) performance enhancement is needed. If all such opportunities for future missions are considered, many uses of SEP are likely. Representative missions are surveyed and several SEP applications selected for analysis, including orbit raising, lunar science and robotic exploration, and planetary science. These missions span SEP power range from 10 kWe to about 100 kWe. A SEP design compatible with small inexpensive launch vehicles, and capable of lunar science missions, is presented. Modes of use and benefits are described, and potential SEP evolution is discussed.

Considerations for the application of finite element beam modeling to vibration analysis of flight vehicle structures. Ph.D. Thesis - Case Western Reserve Univ.

NASA Technical Reports Server (NTRS)

Kvaternik, R. G.

1976-01-01

The manner of representing a flight vehicle structure as an assembly of beam, spring, and rigid-body components for vibration analysis is described. The development is couched in terms of a substructures methodology which is based on the finite-element stiffness method. The particular manner of employing beam, spring, and rigid-body components to model such items as wing structures, external stores, pylons supporting engines or external stores, and sprung masses associated with launch vehicle fuel slosh is described by means of several simple qualitative examples. A detailed numerical example consisting of a tilt-rotor VTOL aircraft is included to provide a unified illustration of the procedure for representing a structure as an equivalent system of beams, springs, and rigid bodies, the manner of forming the substructure mass and stiffness matrices, and the mechanics of writing the equations of constraint which enforce deflection compatibility at the junctions of the substructures. Since many structures, or selected components of structures, can be represented in this manner for vibration analysis, the modeling concepts described and their application in the numerical example shown should prove generally useful to the dynamicist.

Light field imaging and application analysis in THz

NASA Astrophysics Data System (ADS)

Zhang, Hongfei; Su, Bo; He, Jingsuo; Zhang, Cong; Wu, Yaxiong; Zhang, Shengbo; Zhang, Cunlin

2018-01-01

The light field includes the direction information and location information. Light field imaging can capture the whole light field by single exposure. The four-dimensional light field function model represented by two-plane parameter, which is proposed by Levoy, is adopted in the light field. Acquisition of light field is based on the microlens array, camera array and the mask. We calculate the dates of light-field to synthetize light field image. The processing techniques of light field data include technology of refocusing rendering, technology of synthetic aperture and technology of microscopic imaging. Introducing the technology of light field imaging into THz, the efficiency of 3D imaging is higher than that of conventional THz 3D imaging technology. The advantages compared with visible light field imaging include large depth of field, wide dynamic range and true three-dimensional. It has broad application prospects.

Recent advancements in chemical luminescence-based lab-on-chip and microfluidic platforms for bioanalysis.

PubMed

Mirasoli, Mara; Guardigli, Massimo; Michelini, Elisa; Roda, Aldo

2014-01-01

Miniaturization of analytical procedures through microchips, lab-on-a-chip or micro total analysis systems is one of the most recent trends in chemical and biological analysis. These systems are designed to perform all the steps in an analytical procedure, with the advantages of low sample and reagent consumption, fast analysis, reduced costs, possibility of extra-laboratory application. A range of detection technologies have been employed in miniaturized analytical systems, but most applications relied on fluorescence and electrochemical detection. Chemical luminescence (which includes chemiluminescence, bioluminescence, and electrogenerated chemiluminescence) represents an alternative detection principle that offered comparable (or better) analytical performance and easier implementation in miniaturized analytical devices. Nevertheless, chemical luminescence-based ones represents only a small fraction of the microfluidic devices reported in the literature, and until now no review has been focused on these devices. Here we review the most relevant applications (since 2009) of miniaturized analytical devices based on chemical luminescence detection. After a brief overview of the main chemical luminescence systems and of the recent technological advancements regarding their implementation in miniaturized analytical devices, analytical applications are reviewed according to the nature of the device (microfluidic chips, microchip electrophoresis, lateral flow- and paper-based devices) and the type of application (micro-flow injection assays, enzyme assays, immunoassays, gene probe hybridization assays, cell assays, whole-cell biosensors). Copyright © 2013 Elsevier B.V. All rights reserved.

Large-screen display industry: market and technology trends for direct view and projection displays

NASA Astrophysics Data System (ADS)

Castellano, Joseph A.; Mentley, David E.

1996-03-01

Large screen information displays are defined as dynamic electronic displays that can be viewed by more than one person and are at least 2-feet wide. These large area displays for public viewing provide convenience, entertainment, security, and efficiency to the viewers. There are numerous uses for large screen information displays including those in advertising, transportation, traffic control, conference room presentations, computer aided design, banking, and military command/control. A noticeable characteristic of the large screen display market is the interchangeability of display types. For any given application, the user can usually choose from at least three alternative technologies, and sometimes from many more. Some display types have features that make them suitable for specific applications due to temperature, brightness, power consumption, or other such characteristic. The overall worldwide unit consumption of large screen information displays of all types and for all applications (excluding consumer TV) will increase from 401,109 units in 1995 to 655,797 units in 2002. On a unit consumption basis, applications in business and education represent the largest share of unit consumption over this time period; in 1995, this application represented 69.7% of the total. The market (value of shipments) will grow from DOL3.1 billion in 1995 to DOL3.9 billion in 2002. The market will be dominated by front LCD projectors and LCD overhead projector plates.

20 CFR 416.624 - How do we investigate a representative payee applicant?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How do we investigate a representative payee applicant? 416.624 Section 416.624 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Representative Payment § 416.624 How do we investigate a...

40 CFR 415.332 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... SOURCE CATEGORY Carbon Monoxide and By-Product Hydrogen Production Subcategory § 415.332 Effluent limitations guidelines representing the degree of effluent reduction attainable by the application of the best... representing the degree of effluent reduction attainable by the application of the best practicable control...

Colleges Use Field Representatives To Get Close to Potential Applicants.

ERIC Educational Resources Information Center

Gose, Ben

1997-01-01

Increasingly, colleges and universities are using field offices and representatives to recruit applicants at a distance from the institutions. Representatives often spend significant amounts of time with a single student. The practice is particularly popular among colleges wishing to build name recognition and to elevate a narrow market segment in…

Application of vascular aquatic plants for pollution removal, energy and food production in a biological system

NASA Technical Reports Server (NTRS)

Wolverton, B. C.; Barlow, R. M.; Mcdonald, R. C.

1975-01-01

Vascular aquatic plants such as water hyacinths (Eichhornia crassipes) (Mart.) Solms and alligator weeds (Alternanthera philoxeroides) (Mart.) Griesb., when utilized in a controlled biological system (including a regular program of harvesting to achieve maximum growth and pollution removal efficiency), may represent a remarkably efficient and inexpensive filtration and disposal system for toxic materials and sewage released into waters near urban and industrial areas. The harvested and processed plant materials are sources of energy, fertilizer, animal feed, and human food. Such a system has industrial, municipal, and agricultural applications.

Application of vascular aquatic plants for pollution removal, energy, and food production in a biological system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolverton, B.C.; Barlow, R.M.; Mcdonald, R.C.

1975-05-12

Vascular aquatic plants such as water hyacinths (Eichhornia crassipes) (Mart.) Solms and alligator weeds (Alternanthera philoxeroides) (Mart.) Griesb., when utilized in a controlled biological system (including a regular program of harvesting to achieve maximum growth and pollution removal efficiency), may represent a remarkably efficient and inexpensive filtration and disposal system for toxic materials and sewage released into waters near urban and industrial areas. The harvested and processed plant materials are sources of energy, fertilizer, animal feed, and human food. Such a system has industrial, municipal, and agricultural applications. (Author) (GRA)

Advances with holographic DESA emulsions

NASA Astrophysics Data System (ADS)

Dünkel, Lothar; Eichler, Jürgen; Schneeweiss, Claudia; Ackermann, Gerhard

2006-02-01

DESA emulsions represent layer systems based on ultra-fine grained silver halide (AgX) technology. The new layers have an excellent performance for holographic application. The technology has been presented repeatedly in recent years, including the emulsion characterization and topics of chemical and spectral sensitization. The paper gives a survey of actual results referring to panchromatic sensitization and other improvements like the application of silver halide sensitized gelatine (SHSG) procedure. These results are embedded into intensive collaborations with small and medium enterprises (SME's) to commercialize DESA layers. Predominant goals are innovative products with holographic components and layers providing as well as cost effectiveness and high quality.

The Making of SPINdle

NASA Astrophysics Data System (ADS)

Lam, Ho-Pun; Governatori, Guido

We present the design and implementation of SPINdle - an open source Java based defeasible logic reasoner capable to perform efficient and scalable reasoning on defeasible logic theories (including theories with over 1 million rules). The implementation covers both the standard and modal extensions to defeasible logics. It can be used as a standalone theory prover and can be embedded into any applications as a defeasible logic rule engine. It allows users or agents to issues queries, on a given knowledge base or a theory generated on the fly by other applications, and automatically produces the conclusions of its consequences. The theory can also be represented using XML.

Face Processing: Models For Recognition

NASA Astrophysics Data System (ADS)

Turk, Matthew A.; Pentland, Alexander P.

1990-03-01

The human ability to process faces is remarkable. We can identify perhaps thousands of faces learned throughout our lifetime and read facial expression to understand such subtle qualities as emotion. These skills are quite robust, despite sometimes large changes in the visual stimulus due to expression, aging, and distractions such as glasses or changes in hairstyle or facial hair. Computers which model and recognize faces will be useful in a variety of applications, including criminal identification, human-computer interface, and animation. We discuss models for representing faces and their applicability to the task of recognition, and present techniques for identifying faces and detecting eye blinks.

40 CFR 445.23 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... achievable (BAT). 445.23 Section 445.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... the application of the best available technology economically achievable (BAT). Except as provided in... effluent limitations which represent the application of BAT: Limitations for ammonia (as N), a-terpineol...

40 CFR 445.13 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... achievable (BAT). 445.13 Section 445.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... the application of best available technology economically achievable (BAT). Except as provided in 40... following effluent limitations which represent the application of BAT: Limitations for ammonia (as N), a...

40 CFR 418.73 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... effluent reduction attainable by the application of the best available technology economically achievable... subpart after application of the best available technology economically achievable: There shall be no...

40 CFR 418.63 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... application of the best available technology economically achievable: There shall be no discharge of process... representing the degree of effluent reduction attainable by the application of the best available technology... attainable by the application of the best available technology economically achievable. The following...

40 CFR 406.73 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... application of the best available technology economically achievable. The following limitations establish the... subject to the provisions of this subpart after application of the best available technology economically...

40 CFR 406.83 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... application of the best available technology economically achievable. The following limitations establish the... subject to the provisions of this subpart after application of the best available technology economically...

40 CFR 440.142 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... degree of effluent reduction attainable by the application of the best practicable control technology... Placer Mine Subcategory § 440.142 Effluent limitations representing the degree of effluent reduction attainable by the application of the best practicable control technology currently available (BPT). Except as...

40 CFR 440.142 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2014 CFR

2014-07-01

... degree of effluent reduction attainable by the application of the best practicable control technology... Placer Mine Subcategory § 440.142 Effluent limitations representing the degree of effluent reduction attainable by the application of the best practicable control technology currently available (BPT). Except as...

40 CFR 440.142 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... degree of effluent reduction attainable by the application of the best practicable control technology... Placer Mine Subcategory § 440.142 Effluent limitations representing the degree of effluent reduction attainable by the application of the best practicable control technology currently available (BPT). Except as...

40 CFR 408.202 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.292 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... degree of effluent reduction attainable by the application of the best practicable control technology... reduction attainable by the application of the best practicable control technology currently available (BPT...

40 CFR 408.292 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... degree of effluent reduction attainable by the application of the best practicable control technology... reduction attainable by the application of the best practicable control technology currently available (BPT...

40 CFR 408.292 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... degree of effluent reduction attainable by the application of the best practicable control technology... reduction attainable by the application of the best practicable control technology currently available (BPT...

40 CFR 408.202 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.292 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... degree of effluent reduction attainable by the application of the best practicable control technology... reduction attainable by the application of the best practicable control technology currently available (BPT...

40 CFR 408.202 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.292 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... degree of effluent reduction attainable by the application of the best practicable control technology... reduction attainable by the application of the best practicable control technology currently available (BPT...

40 CFR 408.202 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

40 CFR 408.202 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... the degree of effluent reduction attainable by the application of the best practicable control... effluent reduction attainable by the application of the best practicable control technology currently...

5 CFR 831.2106 - Processing applications for deposit for service.

Code of Federal Regulations, 2010 CFR

2010-01-01

... applications for deposit for service. (a) The agency, Clerk of the House of Representatives, or Secretary of... estimated earnings, the agency, Clerk of the House of Representatives, or Secretary of the Senate shall.... (c) If interest is applicable, it shall be computed in accordance with instructions published by OPM...

5 CFR 831.2106 - Processing applications for deposit for service.

Code of Federal Regulations, 2011 CFR

2011-01-01

... applications for deposit for service. (a) The agency, Clerk of the House of Representatives, or Secretary of... estimated earnings, the agency, Clerk of the House of Representatives, or Secretary of the Senate shall.... (c) If interest is applicable, it shall be computed in accordance with instructions published by OPM...

40 CFR 468.16 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best conventional pollution control... application of the best conventional pollution control technology (BCT). [Reserved] ...

40 CFR 468.16 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best conventional pollution control... application of the best conventional pollution control technology (BCT). [Reserved] ...

40 CFR 430.114 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... degree of effluent reduction attainable by the application of the best available technology economically... representing the degree of effluent reduction attainable by the application of the best available technology... best available technology economically achievable (BAT). Non-continuous dischargers shall not be...

40 CFR 468.16 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best conventional pollution control... application of the best conventional pollution control technology (BCT). [Reserved] ...

40 CFR 468.16 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best conventional pollution control... application of the best conventional pollution control technology (BCT). [Reserved] ...

40 CFR 468.16 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best conventional pollution control... application of the best conventional pollution control technology (BCT). [Reserved] ...

Application of damage tolerance methodology in certification of the Piaggio P-180 Avanti

NASA Technical Reports Server (NTRS)

Johnson, Jerry

1992-01-01

The Piaggio P-180 Avanti, a twin pusher-prop engine nine-passenger business aircraft was certified in 1990, to the requirements of FAR Part 23 and Associated Special Conditions for Composite Structure. Certification included the application of a damage tolerant methodology to the design of the composite forward wing and empennage (vertical fin, horizontal stabilizer, tailcone, and rudder) structure. This methodology included an extensive analytical evaluation coupled with sub-component and full-scale testing of the structure. The work from the Damage Tolerance Analysis Assessment was incorporated into the full-scale testing. Damage representing hazards such as dropped tools, ground equipment, handling, and runway debris, was applied to the test articles. Additional substantiation included allowing manufacturing discrepancies to exist unrepaired on the full-scale articles and simulated bondline failures in critical elements. The importance of full-scale testing in the critical environmental conditions and the application of critical damage are addressed. The implication of damage tolerance on static and fatigue testing is discussed. Good correlation between finite element solutions and experimental test data was observed.

Applications of self-organizing neural networks in virtual screening and diversity selection.

PubMed

Selzer, Paul; Ertl, Peter

2006-01-01

Artificial neural networks provide a powerful technique for the analysis and modeling of nonlinear relationships between molecular structures and pharmacological activity. Many network types, including Kohonen and counterpropagation, also provide an intuitive method for the visual assessment of correspondence between the input and output data. This work shows how a combination of neural networks and radial distribution function molecular descriptors can be applied in various areas of industrial pharmaceutical research. These applications include the prediction of biological activity, the selection of screening candidates (cherry picking), and the extraction of representative subsets from large compound collections such as combinatorial libraries. The methods described have also been implemented as an easy-to-use Web tool, allowing chemists to perform interactive neural network experiments on the Novartis intranet.

Isolated and coupled superquadric loop antennas for mobile communications applications

NASA Technical Reports Server (NTRS)

Jensen, Michael A.; Rahmat-Samii, Yahya

1993-01-01

This work provides an investigation of the performance of loop antennas for use in mobile communications applications. The analysis tools developed allow for high flexibility by representing the loop antenna as a superquadric curve, which includes the case of circular, elliptical, and rectangular loops. The antenna may be in an isolated environment, located above an infinite ground plane, or placed near a finite conducting plate or box. In cases where coupled loops are used, the two loops may have arbitrary relative positions and orientations. Several design examples are included to illustrate the versatility of the analysis capabilities. The performance of coupled loops arranged in a diversity scheme is also evaluated, and it is found that high diversity gain can be achieved even when the antennas are closely spaced.

CAD-model-based vision for space applications

NASA Technical Reports Server (NTRS)

Shapiro, Linda G.

1988-01-01

A pose acquisition system operating in space must be able to perform well in a variety of different applications including automated guidance and inspections tasks with many different, but known objects. Since the space station is being designed with automation in mind, there will be CAD models of all the objects, including the station itself. The construction of vision models and procedures directly from the CAD models is the goal of this project. The system that is being designed and implementing must convert CAD models to vision models, predict visible features from a given view point from the vision models, construct view classes representing views of the objects, and use the view class model thus derived to rapidly determine the pose of the object from single images and/or stereo pairs.

AQUA-USERS: AQUAculture USEr Driven Operational Remote Sensing Information Services

NASA Astrophysics Data System (ADS)

Laanen, Marnix; Poser, Kathrin; Peters, Steef; de Reus, Nils; Ghebrehiwot, Semhar; Eleveld, Marieke; Miller, Peter; Groom, Steve; Clements, Oliver; Kurekin, Andrey; Martinez Vicente, Victor; Brotas, Vanda; Sa, Carolina; Couto, Andre; Brito, Ana; Amorim, Ana; Dale, Trine; Sorensen, Kai; Boye Hansen, Lars; Huber, Silvia; Kaas, Hanne; Andersson, Henrik; Icely, John; Fragoso, Bruno

2015-12-01

The FP7 project AQUA-USERS provides the aquaculture industry with user-relevant and timely information based on the most up-to-date satellite data and innovative optical in-situ measurements. Its key purpose is to develop an application that brings together satellite information on water quality and temperature with in-situ observations as well as relevant weather prediction and met-ocean data. The application and its underlying database are linked to a decision support system that includes a set of (user-determined) management options. Specific focus is on the development of indicators for aquaculture management including indicators for harmful algae bloom (HAB) events. The methods and services developed within AQUA-USERS are tested by the members of the user board, who represent different geographic areas and aquaculture production systems.

Transportable Applications Environment (TAE) Tenth Users' Conference

NASA Technical Reports Server (NTRS)

Rouff, Chris (Editor); Harris, Elfrieda (Editor); Yeager, Arleen (Editor)

1993-01-01

Conference proceedings are represented in graphic visual-aid form. Presentation and panel discussion topics include user experiences with C++ and Ada; the design and interaction of the user interface; the history and goals of TAE; commercialization and testing of TAE Plus; Computer-Human Interaction Models (CHIMES); data driven objects; item-to-item connections and object dependencies; and integration with other software. There follows a list of conference attendees.

Development and Demonstration of Communication Systems for the Blind and Deaf/Blind. Braille Communication Terminals and Tactile Paging Systems. Final Report.

ERIC Educational Resources Information Center

Dalrymple, George F.

Described is the BRAILLEMBOSS, a braille page printer, which is useful as a short run braille producer and as an employment and education tool for the blind and deaf blind. Examples of applications are given, including its use by computer programers, students, taxpayer service representatives, and news broadcasters. The machine is, for blind…

Knowledge, Skills, and Abilities for Military Leader Influence

DTIC Science & Technology

2011-03-01

tactics. The attributes vary in breadth, encompassing broad traits, such as those represented in the five-factor model of personality ( FFM ; e.g...attributes related to the application of influence strategies, together with their definitions, are shown in Table 10. The FFM includes extroversion...leadership. For example, Judge, Bono, Ilies, and Gerhardt (2002) conducted a meta-analysis investigating the relationship between FFM personality traits

Federal Textbook on Citizenship. Our Constitution and Government: Lessons on the Constitution and Government of the United States for Use in the Public Schools by Candidates for Citizenship.

ERIC Educational Resources Information Center

Seckler-Hudson, Catheryn

Thirty lessons, including 60 illustrations of maps and charts, provide a study framework for candidates preparing for their naturalization examinations as applicants for U. S. citizenship. Representative government is described in terms of group associations, comparing family, community, church, school, city, state, and national organization. The…

A Meteorological Supersite for Aviation and Cold Weather Applications

NASA Astrophysics Data System (ADS)

Gultepe, Ismail; Agelin-Chaab, M.; Komar, J.; Elfstrom, G.; Boudala, F.; Zhou, B.

2018-05-01

The goal of this study is to better understand atmospheric boundary layer processes and parameters, and to evaluate physical processes for aviation applications using data from a supersite observing site. Various meteorological sensors, including a weather and environmental unmanned aerial vehicle (WE-UAV), and a fog and snow tower (FSOS) observations are part of the project. The PanAm University of Ontario Institute of Technology (UOIT) Meteorological Supersite (PUMS) observations are being collected from April 2015 to date. The FSOS tower gathers observations related to rain, snow, fog, and visibility, aerosols, solar radiation, and wind and turbulence, as well as surface and sky temperature. The FSOSs are located at three locations at about 450-800 m away from the PUMS supersite. The WE-UAV measurements representing aerosol, wind speed and direction, as well as temperature (T) and relative humidity (RH) are provided during clear weather conditions. Other measurements at the PUMS site include cloud backscattering profiles from CL51 ceilometer, MWR observations of liquid water content (LWC), T, and RH, and Microwave Rain Radar (MRR) reflectivity profile, as well as the present weather type, snow water depth, icing rate, 3D-ultrasonic wind and turbulence, and conventional meteorological observations from compact weather stations, e.g., WXTs. The results based on important weather event studies, representing fog, snow, rain, blowing snow, wind gust, planetary boundary layer (PBL) wind research for UAV, and icing conditions are given. The microphysical parameterizations and analysis processes for each event are provided, but the results should not be generalized for all weather events and be used cautiously. Results suggested that integrated observing systems based on data from a supersite as well as satellite sites can provide better information applicable to aviation meteorology, including PBL weather research, validation of numerical weather model predictions, and remote-sensing retrievals. Overall, the results from the five cases are provided and challenges related to observations applicable to aviation meteorology are discussed.

Validation of a New Web Application for Identification of Fungi by Use of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

PubMed Central

Becker, P.; Gabriel, F.; Cassagne, C.; Accoceberry, I.; Gari-Toussaint, M.; Hasseine, L.; De Geyter, D.; Pierard, D.; Surmont, I.; Djenad, F.; Donnadieu, J. L.; Piarroux, M.; Hendrickx, M.; Piarroux, R.

2017-01-01

ABSTRACT Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry has emerged as a reliable technique to identify molds involved in human diseases, including dermatophytes, provided that exhaustive reference databases are available. This study assessed an online identification application based on original algorithms and an extensive in-house reference database comprising 11,851 spectra (938 fungal species and 246 fungal genera). Validation criteria were established using an initial panel of 422 molds, including dermatophytes, previously identified via DNA sequencing (126 species). The application was further assessed using a separate panel of 501 cultured clinical isolates (88 mold taxa including dermatophytes) derived from five hospital laboratories. A total of 438 (87.35%) isolates were correctly identified at the species level, while 26 (5.22%) were assigned to the correct genus but the wrong species and 37 (7.43%) were not identified, since the defined threshold of 20 was not reached. The use of the Bruker Daltonics database included in the MALDI Biotyper software resulted in a much higher rate of unidentified isolates (39.76 and 74.30% using the score thresholds 1.7 and 2.0, respectively). Moreover, the identification delay of the online application remained compatible with real-time online queries (0.15 s per spectrum), and the application was faster than identifications using the MALDI Biotyper software. This is the first study to assess an online identification system based on MALDI-TOF spectrum analysis. We have successfully applied this approach to identify molds, including dermatophytes, for which diversity is insufficiently represented in commercial databases. This free-access application is available to medical mycologists to improve fungal identification. PMID:28637907

Validation of a New Web Application for Identification of Fungi by Use of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.

PubMed

Normand, A C; Becker, P; Gabriel, F; Cassagne, C; Accoceberry, I; Gari-Toussaint, M; Hasseine, L; De Geyter, D; Pierard, D; Surmont, I; Djenad, F; Donnadieu, J L; Piarroux, M; Ranque, S; Hendrickx, M; Piarroux, R

2017-09-01

Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry has emerged as a reliable technique to identify molds involved in human diseases, including dermatophytes, provided that exhaustive reference databases are available. This study assessed an online identification application based on original algorithms and an extensive in-house reference database comprising 11,851 spectra (938 fungal species and 246 fungal genera). Validation criteria were established using an initial panel of 422 molds, including dermatophytes, previously identified via DNA sequencing (126 species). The application was further assessed using a separate panel of 501 cultured clinical isolates (88 mold taxa including dermatophytes) derived from five hospital laboratories. A total of 438 (87.35%) isolates were correctly identified at the species level, while 26 (5.22%) were assigned to the correct genus but the wrong species and 37 (7.43%) were not identified, since the defined threshold of 20 was not reached. The use of the Bruker Daltonics database included in the MALDI Biotyper software resulted in a much higher rate of unidentified isolates (39.76 and 74.30% using the score thresholds 1.7 and 2.0, respectively). Moreover, the identification delay of the online application remained compatible with real-time online queries (0.15 s per spectrum), and the application was faster than identifications using the MALDI Biotyper software. This is the first study to assess an online identification system based on MALDI-TOF spectrum analysis. We have successfully applied this approach to identify molds, including dermatophytes, for which diversity is insufficiently represented in commercial databases. This free-access application is available to medical mycologists to improve fungal identification. Copyright © 2017 American Society for Microbiology.

Development and validation of the social information processing application: a Web-based measure of social information processing patterns in elementary school-age boys.

PubMed

Kupersmidt, Janis B; Stelter, Rebecca; Dodge, Kenneth A

2011-12-01

The purpose of this study was to evaluate the psychometric properties of an audio computer-assisted self-interviewing Web-based software application called the Social Information Processing Application (SIP-AP) that was designed to assess social information processing skills in boys in 3rd through 5th grades. This study included a racially and ethnically diverse sample of 244 boys ages 8 through 12 (M = 9.4) from public elementary schools in 3 states. The SIP-AP includes 8 videotaped vignettes, filmed from the first-person perspective, that depict common misunderstandings among boys. Each vignette shows a negative outcome for the victim and ambiguous intent on the part of the perpetrator. Boys responded to 16 Web-based questions representing the 5 social information processing mechanisms, after viewing each vignette. Parents and teachers completed measures assessing boys' antisocial behavior. Confirmatory factor analyses revealed that a model positing the original 5 cognitive mechanisms fit the data well when the items representing prosocial cognitions were included on their own factor, creating a 6th factor. The internal consistencies for each of the 16 individual cognitions as well as for the 6 cognitive mechanism scales were excellent. Boys with elevated scores on 5 of the 6 cognitive mechanisms exhibited more antisocial behavior than boys whose scores were not elevated. These findings highlight the need for further research on the measurement of prosocial cognitions or cognitive strengths in boys in addition to assessing cognitive deficits. Findings suggest that the SIP-AP is a reliable and valid tool for use in future research of social information processing skills in boys.

Development and Validation of the Social Information Processing Application: A Web-Based Measure of Social Information Processing Patterns in Elementary School-Age Boys

PubMed Central

Kupersmidt, Janis B.; Stelter, Rebecca; Dodge, Kenneth A.

2013-01-01

The purpose of this study was to evaluate the psychometric properties of an audio computer-assisted self-interviewing Web-based software application called the Social Information Processing Application (SIP-AP) that was designed to assess social information processing skills in boys in 3rd through 5th grades. This study included a racially and ethnically diverse sample of 244 boys ages 8 through 12 (M = 9.4) from public elementary schools in 3 states. The SIP-AP includes 8 videotaped vignettes, filmed from the first-person perspective, that depict common misunderstandings among boys. Each vignette shows a negative outcome for the victim and ambiguous intent on the part of the perpetrator. Boys responded to 16 Web-based questions representing the 5 social information processing mechanisms, after viewing each vignette. Parents and teachers completed measures assessing boys’ antisocial behavior. Confirmatory factor analyses revealed that a model positing the original 5 cognitive mechanisms fit the data well when the items representing prosocial cognitions were included on their own factor, creating a 6th factor. The internal consistencies for each of the 16 individual cognitions as well as for the 6 cognitive mechanism scales were excellent. Boys with elevated scores on 5 of the 6 cognitive mechanisms exhibited more antisocial behavior than boys whose scores were not elevated. These findings highlight the need for further research on the measurement of prosocial cognitions or cognitive strengths in boys in addition to assessing cognitive deficits. Findings suggest that the SIP-AP is a reliable and valid tool for use in future research of social information processing skills in boys. PMID:21534693

X-38 Application of Dynamic Inversion Flight Control

NASA Technical Reports Server (NTRS)

Wacker, Roger; Munday, Steve; Merkle, Scott

2001-01-01

This paper summarizes the application of a nonlinear dynamic inversion (DI) flight control system (FCS) to an autonomous flight test vehicle in NASA's X-38 Project, a predecessor to the International Space Station (ISS) Crew Return Vehicle (CRV). Honeywell's Multi-Application Control-H (MACH) is a parameterized FCS design architecture including both model-based DI rate-compensation and classical P+I command-tracking. MACH was adopted by X-38 in order to shorten the design cycle time for different vehicle shapes and flight envelopes and evolving aerodynamic databases. Specific design issues and analysis results are presented for the application of MACH to the 3rd free flight (FF3) of X-38 Vehicle 132 (V132). This B-52 drop test, occurring on March 30, 2000, represents the first flight test of MACH and one of the first few known applications of DI in the primary FCS of an autonomous flight test vehicle.

Demonstrating a Realistic IP Mission Prototype

NASA Technical Reports Server (NTRS)

Rash, James; Ferrer, Arturo B.; Goodman, Nancy; Ghazi-Tehrani, Samira; Polk, Joe; Johnson, Lorin; Menke, Greg; Miller, Bill; Criscuolo, Ed; Hogie, Keith

2003-01-01

Flight software and hardware and realistic space communications environments were elements of recent demonstrations of the Internet Protocol (IP) mission concept in the lab. The Operating Missions as Nodes on the Internet (OMNI) Project and the Flight Software Branch at NASA/GSFC collaborated to build the prototype of a representative space mission that employed unmodified off-the-shelf Internet protocols and technologies for end-to-end communications between the spacecraft/instruments and the ground system/users. The realistic elements used in the prototype included an RF communications link simulator and components of the TRIANA mission flight software and ground support system. A web-enabled camera connected to the spacecraft computer via an Ethernet LAN represented an on-board instrument creating image data. In addition to the protocols at the link layer (HDLC), transport layer (UDP, TCP), and network (IP) layer, a reliable file delivery protocol (MDP) at the application layer enabled reliable data delivery both to and from the spacecraft. The standard Network Time Protocol (NTP) performed on-board clock synchronization with a ground time standard. The demonstrations of the prototype mission illustrated some of the advantages of using Internet standards and technologies for space missions, but also helped identify issues that must be addressed. These issues include applicability to embedded real-time systems on flight-qualified hardware, range of applicability of TCP, and liability for and maintenance of commercial off-the-shelf (COTS) products. The NASA Earth Science Technology Office (ESTO) funded the collaboration to build and demonstrate the prototype IP mission.

Ground Operations Autonomous Control and Integrated Health Management

NASA Technical Reports Server (NTRS)

Daniels, James

2014-01-01

The Ground Operations Autonomous Control and Integrated Health Management plays a key role for future ground operations at NASA. The software that is integrated into this system is called G2 2011 Gensym. The purpose of this report is to describe the Ground Operations Autonomous Control and Integrated Health Management with the use of the G2 Gensym software and the G2 NASA toolkit for Integrated System Health Management (ISHM) which is a Computer Software Configuration Item (CSCI). The decision rationale for the use of the G2 platform is to develop a modular capability for ISHM and AC. Toolkit modules include knowledge bases that are generic and can be applied in any application domain module. That way, there's a maximization of reusability, maintainability, and systematic evolution, portability, and scalability. Engine modules are generic, while application modules represent the domain model of a specific application. Furthermore, the NASA toolkit, developed since 2006 (a set of modules), makes it possible to create application domain models quickly, using pre-defined objects that include sensors and components libraries for typical fluid, electrical, and mechanical systems.

Singlet oxygen generation by cyclometalated complexes and applications.

PubMed

Ashen-Garry, David; Selke, Matthias

2014-01-01

While cyclometalated complexes have been extensively studied for optoelectronic applications, these compounds also represent a relatively new class of photosensitizers for the production of singlet oxygen. Thus far, singlet oxygen generation from cyclometalated Ir and Pt complexes has been studied in detail. In this review, photophysical data for singlet oxygen generation from these complexes are presented, and the mechanism of (1) O2 generation is discussed, including evidence for singlet oxygen generation via an electron-transfer mechanism for some of cyclometalated Ir complexes. The period from the first report of singlet oxygen generation by a cyclometalated Ir complex in 2002 through August 2013 is covered in this review. This new class of singlet oxygen photosensitizers may prove to be rather versatile due to the ease of substitution of ancillary ligands without loss of activity. Several cyclometalated complexes have been tethered to zeolites, polystyrene, or quantum dots. Applications for photooxygenation of organic molecules, including "traditional" singlet oxygen reactions (ene reaction, [4 + 2] and [2 + 2] cycloadditions) as well as oxidative coupling of amines are presented. Potential biomedical applications are also reviewed. © 2013 The American Society of Photobiology.

Web mapping system for complex processing and visualization of environmental geospatial datasets

NASA Astrophysics Data System (ADS)

Titov, Alexander; Gordov, Evgeny; Okladnikov, Igor

2016-04-01

Environmental geospatial datasets (meteorological observations, modeling and reanalysis results, etc.) are used in numerous research applications. Due to a number of objective reasons such as inherent heterogeneity of environmental datasets, big dataset volume, complexity of data models used, syntactic and semantic differences that complicate creation and use of unified terminology, the development of environmental geodata access, processing and visualization services as well as client applications turns out to be quite a sophisticated task. According to general INSPIRE requirements to data visualization geoportal web applications have to provide such standard functionality as data overview, image navigation, scrolling, scaling and graphical overlay, displaying map legends and corresponding metadata information. It should be noted that modern web mapping systems as integrated geoportal applications are developed based on the SOA and might be considered as complexes of interconnected software tools for working with geospatial data. In the report a complex web mapping system including GIS web client and corresponding OGC services for working with geospatial (NetCDF, PostGIS) dataset archive is presented. There are three basic tiers of the GIS web client in it: 1. Tier of geospatial metadata retrieved from central MySQL repository and represented in JSON format 2. Tier of JavaScript objects implementing methods handling: --- NetCDF metadata --- Task XML object for configuring user calculations, input and output formats --- OGC WMS/WFS cartographical services 3. Graphical user interface (GUI) tier representing JavaScript objects realizing web application business logic Metadata tier consists of a number of JSON objects containing technical information describing geospatial datasets (such as spatio-temporal resolution, meteorological parameters, valid processing methods, etc). The middleware tier of JavaScript objects implementing methods for handling geospatial metadata, task XML object, and WMS/WFS cartographical services interconnects metadata and GUI tiers. The methods include such procedures as JSON metadata downloading and update, launching and tracking of the calculation task running on the remote servers as well as working with WMS/WFS cartographical services including: obtaining the list of available layers, visualizing layers on the map, exporting layers in graphical (PNG, JPG, GeoTIFF), vector (KML, GML, Shape) and digital (NetCDF) formats. Graphical user interface tier is based on the bundle of JavaScript libraries (OpenLayers, GeoExt and ExtJS) and represents a set of software components implementing web mapping application business logic (complex menus, toolbars, wizards, event handlers, etc.). GUI provides two basic capabilities for the end user: configuring the task XML object functionality and cartographical information visualizing. The web interface developed is similar to the interface of such popular desktop GIS applications, as uDIG, QuantumGIS etc. Web mapping system developed has shown its effectiveness in the process of solving real climate change research problems and disseminating investigation results in cartographical form. The work is supported by SB RAS Basic Program Projects VIII.80.2.1 and IV.38.1.7.

37 CFR 2.24 - Designation and revocation of domestic representative by foreign applicant.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the mark may be served) by either: (i) Setting forth the name and address of the domestic representative in the initial application; or (ii) Filing a separate designation setting forth the name and... applicant (e.g., a corporate officer or general partner of a partnership), or a practitioner qualified to...

37 CFR 2.24 - Designation and revocation of domestic representative by foreign applicant.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the mark may be served) by either: (i) Setting forth the name and address of the domestic representative in the initial application; or (ii) Filing a separate designation setting forth the name and... applicant (e.g., a corporate officer or general partner of a partnership), or a practitioner qualified to...

37 CFR 2.24 - Designation and revocation of domestic representative by foreign applicant.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the mark may be served) by either: (i) Setting forth the name and address of the domestic representative in the initial application; or (ii) Filing a separate designation setting forth the name and... applicant (e.g., a corporate officer or general partner of a partnership), or a practitioner qualified to...

37 CFR 2.24 - Designation and revocation of domestic representative by foreign applicant.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the mark may be served) by either: (i) Setting forth the name and address of the domestic representative in the initial application; or (ii) Filing a separate designation setting forth the name and... applicant (e.g., a corporate officer or general partner of a partnership), or a practitioner qualified to...

37 CFR 2.24 - Designation and revocation of domestic representative by foreign applicant.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the mark may be served) by either: (i) Setting forth the name and address of the domestic representative in the initial application; or (ii) Filing a separate designation setting forth the name and... applicant (e.g., a corporate officer or general partner of a partnership), or a practitioner qualified to...

Energy Device Applications of Synthesized 1D Polymer Nanomaterials.

PubMed

Huang, Long-Biao; Xu, Wei; Hao, Jianhua

2017-11-01

1D polymer nanomaterials as emerging materials, such as nanowires, nanotubes, and nanopillars, have attracted extensive attention in academia and industry. The distinctive, various, and tunable structures in the nanoscale of 1D polymer nanomaterials present nanointerfaces, high surface-to-volume ratio, and large surface area, which can improve the performance of energy devices. In this review, representative fabrication techniques of 1D polymer nanomaterials are summarized, including electrospinning, template-assisted, template-free, and inductively coupled plasma methods. The recent advancements of 1D polymer nanomaterials in energy device applications are demonstrated. Lastly, existing challenges and prospects of 1D polymer nanomaterials for energy device applications are presented. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Illuminating the Chemistry of Life: Design, Synthesis, and Applications of “Caged” and Related Photoresponsive Compounds

PubMed Central

Lee, Hsienming; Larson, Daniel R.; Lawrence, David S.

2009-01-01

Biological systems are characterized by a level of spatial and temporal organization that often lies beyond the grasp of present day methods. Light-modulated bioreagents, including analogs of low molecular weight compounds, peptides, proteins, and nucleic acids, represent a compelling strategy to probe, perturb, or sample biological phenomena with the requisite control to address many of these organizational complexities. Although this technology has created considerable excitement in the chemical community, its application to biological questions has been relatively limited. We describe the challenges associated with the design, synthesis, and use of light-responsive bioreagents, the scope and limitations associated with the instrumentation required for their application, and recent chemical and biological advances in this field. PMID:19298086

Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.

PubMed

Lee, Hsien-Ming; Larson, Daniel R; Lawrence, David S

2009-06-19

Biological systems are characterized by a level of spatial and temporal organization that often lies beyond the grasp of present day methods. Light-modulated bioreagents, including analogs of low molecular weight compounds, peptides, proteins, and nucleic acids, represent a compelling strategy to probe, perturb, or sample biological phenomena with the requisite control to address many of these organizational complexities. Although this technology has created considerable excitement in the chemical community, its application to biological questions has been relatively limited. We describe the challenges associated with the design, synthesis, and use of light-responsive bioreagents; the scope and limitations associated with the instrumentation required for their application; and recent chemical and biological advances in this field.

Inhibition of human papillomavirus expression using DNAzymes.

PubMed

Benítez-Hess, María Luisa; Reyes-Gutiérrez, Pablo; Alvarez-Salas, Luis Marat

2011-01-01

Deoxyribozymes (DXZs) are catalytic oligodeoxynucleotides capable of performing diverse functions including the specific cleavage of a target RNA. These molecules represent a new type of therapeutic oligonucleotides combining the efficiency of ribozymes and the intracellular endurance and simplicity of modified antisense oligonucleotides. Commonly used DXZs include the 8-17 and 10-23 motifs, which have been engineered to destroy disease-associated genes with remarkable efficiency. Targeting DXZs to disease-associated transcripts requires extensive biochemical testing to establish target RNA accessibility, catalytic efficiency, and nuclease sensibility. The usage of modified nucleotides to render nuclease-resistance DXZs must be counterweighted against deleterious consequences on catalytic activity. Further intracellular testing is required to establish the effect of microenvironmental conditions on DXZ activity and off-target issues. Application of modified DXZs to cervical cancer results in specific growth inhibition, cell death, and apoptosis. Thus, DXZs represent a highly effective antisense moiety with minimal secondary effects.

Defining a Mechanism of Educational Interface Between NASA Life Sciences the Nation's Students

NASA Technical Reports Server (NTRS)

Chamberland, D.; Dreschel, T.; Coulter, G.

1995-01-01

Harnessing our greatest national resource, as represented by the nation's students, will require a thoughtful, well developed and administered program that includes precise, executable strategies and valid evaluation tools. Responding to a national education outreach priority, the National Aeronautics and Space Administration's Life and Biomedical Sciences and Applications Division has initiated a process or organizing and implementing various strategies through a steering committee that includes representatives from Headquarters and three field centers with major Life Sciences programs. The mandate of the Life Sciences Education Outreach Steering Committee is to develop ways of communicating space life science issues to America's students through the nation's teachers by curriculum enhancement and direct participation in the education process with an emphasis in the primary and secondary schools. Metrics are also developed for each individually defined process so that the mechanis can be continuously refined and improved.

Effects of environmental sounds on the guessability of animated graphic symbols.

PubMed

Harmon, Ashley C; Schlosser, Ralf W; Gygi, Brian; Shane, Howard C; Kong, Ying-Yee; Book, Lorraine; Macduff, Kelly; Hearn, Emilia

2014-12-01

Graphic symbols are a necessity for pre-literate children who use aided augmentative and alternative communication (AAC) systems (including non-electronic communication boards and speech generating devices), as well as for mobile technologies using AAC applications. Recently, developers of the Autism Language Program (ALP) Animated Graphics Set have added environmental sounds to animated symbols representing verbs in an attempt to enhance their iconicity. The purpose of this study was to examine the effects of environmental sounds (added to animated graphic symbols representing verbs) in terms of naming. Participants included 46 children with typical development between the ages of 3;0 to 3;11 (years;months). The participants were randomly allocated to a condition of symbols with environmental sounds or a condition without environmental sounds. Results indicated that environmental sounds significantly enhanced the naming accuracy of animated symbols for verbs. Implications in terms of symbol selection, symbol refinement, and future symbol development will be discussed.

Hydrology Applications of the GRACE missions

NASA Astrophysics Data System (ADS)

Srinivasan, M. M.; Ivins, E. R.; Jasinski, M. F.

2014-12-01

NASA and their German space agency partners have a rich history of global gravity observations beginning with the launch of the Gravity Recovery And Climate Experiment (GRACE) in 2002. The science goals of the mission include providing monthly maps of variations in the gravity field, where the major time-varying signal is due to water motion in the Earth system. GRACE has a unique ability to observe the mass flux of water movement at monthly time scales. The hydrology applications of the GRACE mission include measurements of seasonal storage of surface and subsurface water and evapotranspiration at the land-ocean-atmosphere boundary. These variables are invaluable for improved modeling and prediction of Earth system processes. Other mission-critical science objectives include measurements that are a key component of NASA's ongoing climate measuring capabilities. Successful strategies to enhance science and practical applications of the proposed GRACE-Follow On (GRACE-FO) mission, scheduled to launch in 2017, will require engaging with and facilitating between representatives in the science, societal applications, and mission planning communities. NASA's Applied Sciences Program is supporting collaboration on an applied approach to identifying communities of potential and of practice in order to identify and promote the societal benefits of these and future gravity missions. The objective is to engage applications-oriented users and organizations and enable them to envision possible applications and end-user needs as a way to increase the benefits of these missions to the nations. The focus of activities for this applications program include; engaging the science community in order to identify applications and current and potential data users, developing a written Applications Plan, conducting workshops and user tutorials, providing ready access to information via web pages, developing databases of key and interested users/scientists, creating printed materials (posters, brochures) that identify key capabilities and applications of the missions and data, and participation in key science meetings and decision support processes.

Energy research and development and space technology. Hearings before the subcommittee on space science and applications and subcommittee on energy of the Committee on Science and Astronautics, U.S. House of Representatives, Ninety-Third Congress, First Session, May 7, 22, and 24, 1973

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1973-01-01

Congressman James Symington was chairman of the Subcommittee on Space Science and Applications of the House Committee on Science and Astronautics. Congressman Mike McCormack was present at the proceedings and witnesses presented data on the development of long-term fuel supplies, a continued search for more reliable and more efficient designs of plants, and the optimization of the impact on society in the use of energy for such things as food, shelter, clothing, heat, light, health, recreation, travel, and education. Then, general problems of the byproducts of the energy-producing processes are examined including fly ash, sulfur oxides, nitrogen, oxides, warm water,more » esthetics, strip mining, and radiation. Representatives from the utilities, national laboratories, gas companies, universities, environmental councils, space agencies, and communication companies presented the data covering all aspects of energy research. (MCW)« less

Aeronautical technology 2000: A projection of advanced vehicle concepts

NASA Technical Reports Server (NTRS)

1985-01-01

The Aeronautics and Space Engineering Board (ASEB) of the National Research Council conducted a Workshop on Aeronautical Technology: a Projection to the Year 2000 (Aerotech 2000 Workshop). The panels were asked to project advances in aeronautical technologies that could be available by the year 2000. As the workshop was drawing to a close, it became evident that a more comprehensive investigation of advanced air vehicle concepts than was possible in the limited time available at the workshop would be valuable. Thus, a special panel on vehicle applications was organized. In the course of two meetings, the panel identified and described representative types of aircraft judged possible with the workshop's technology projections. These representative aircraft types include: military aircraft; transport aircraft; rotorcraft; extremely high altitude aircraft; and transatmospheric aircraft. Improvements in performance, efficiency, and operational characteristics possible through the application of the workshop's year 2000 technology projections were discussed. The subgroups also identified the technologies considered essential and enhancing or supporting to achieve the projected aircraft improvements.

Clinical applications of bioactive milk components

PubMed Central

Newburg, David S.

2015-01-01

Milk represents a unique resource for translational medicine: It contains a rich pool of biologically active molecules with demonstrated clinical benefits. The ongoing characterization of the mechanistic process through which milk components promote development and immunity has revealed numerous milk-derived compounds with potential applications as clinical therapies in infectious and inflammatory disease, cancer, and other conditions. Lactoferrin is an effective antimicrobial and antiviral agent in high-risk patient populations and a potentially potent adjuvant to chemotherapy in lung cancer. Enteric nutrition formulas supplemented with transforming growth factor β, a milk cytokine, have been shown to promote remission in pediatric Crohn's disease. A number of milk glycans, including human milk oligosaccharides, show promise in preclinical studies as antimicrobial and anti-inflammatory agents. While active preclinical investigations of human milk may soon result in large-scale production of human milk molecules, bovine milk components in many instances represent a practical source of bioactive milk compounds for use in clinical trials. This review summarizes current efforts to translate the compounds derived from human and bovine milk into effective clinical therapies. These efforts suggest a common pathway for the translation of milk-derived compounds into clinical applications. PMID:26011900

TOWARD THE DEVELOPMENT OF A CONSENSUS MATERIALS DATABASE FOR PRESSURE TECHNOLGY APPLICATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swindeman, Robert W; Ren, Weiju

The ASME construction code books specify materials and fabrication procedures that are acceptable for pressure technology applications. However, with few exceptions, the materials properties provided in the ASME code books provide no statistics or other information pertaining to material variability. Such information is central to the prediction and prevention of failure events. Many sources of materials data exist that provide variability information but such sources do not necessarily represent a consensus of experts with respect to the reported trends that are represented. Such a need has been identified by the ASME Standards Technology, LLC and initial steps have been takenmore » to address these needs: however, these steps are limited to project-specific applications only, such as the joint DOE-ASME project on materials for Generation IV nuclear reactors. In contrast to light-water reactor technology, the experience base for the Generation IV nuclear reactors is somewhat lacking and heavy reliance must be placed on model development and predictive capability. The database for model development is being assembled and includes existing code alloys such as alloy 800H and 9Cr-1Mo-V steel. Ownership and use rights are potential barriers that must be addressed.« less

Clinical applications of bioactive milk components.

PubMed

Hill, David R; Newburg, David S

2015-07-01

Milk represents a unique resource for translational medicine: It contains a rich pool of biologically active molecules with demonstrated clinical benefits. The ongoing characterization of the mechanistic process through which milk components promote development and immunity has revealed numerous milk-derived compounds with potential applications as clinical therapies in infectious and inflammatory disease, cancer, and other conditions. Lactoferrin is an effective antimicrobial and antiviral agent in high-risk patient populations and a potentially potent adjuvant to chemotherapy in lung cancer. Enteric nutrition formulas supplemented with transforming growth factor β, a milk cytokine, have been shown to promote remission in pediatric Crohn's disease. A number of milk glycans, including human milk oligosaccharides, show promise in preclinical studies as antimicrobial and anti-inflammatory agents. While active preclinical investigations of human milk may soon result in large-scale production of human milk molecules, bovine milk components in many instances represent a practical source of bioactive milk compounds for use in clinical trials. This review summarizes current efforts to translate the compounds derived from human and bovine milk into effective clinical therapies. These efforts suggest a common pathway for the translation of milk-derived compounds into clinical applications.

Virtualization of event sources in wireless sensor networks for the internet of things.

PubMed

Lucas Martínez, Néstor; Martínez, José-Fernán; Hernández Díaz, Vicente

2014-12-01

Wireless Sensor Networks (WSNs) are generally used to collect information from the environment. The gathered data are delivered mainly to sinks or gateways that become the endpoints where applications can retrieve and process such data. However, applications would also expect from a WSN an event-driven operational model, so that they can be notified whenever occur some specific environmental changes instead of continuously analyzing the data provided periodically. In either operational model, WSNs represent a collection of interconnected objects, as outlined by the Internet of Things. Additionally, in order to fulfill the Internet of Things principles, Wireless Sensor Networks must have a virtual representation that allows indirect access to their resources, a model that should also include the virtualization of event sources in a WSN. Thus, in this paper a model for a virtual representation of event sources in a WSN is proposed. They are modeled as internet resources that are accessible by any internet application, following an Internet of Things approach. The model has been tested in a real implementation where a WSN has been deployed in an open neighborhood environment. Different event sources have been identified in the proposed scenario, and they have been represented following the proposed model.

Sample presentation, sources of error and future perspectives on the application of vibrational spectroscopy in the wine industry.

PubMed

Cozzolino, Daniel

2015-03-30

Vibrational spectroscopy encompasses a number of techniques and methods including ultra-violet, visible, Fourier transform infrared or mid infrared, near infrared and Raman spectroscopy. The use and application of spectroscopy generates spectra containing hundreds of variables (absorbances at each wavenumbers or wavelengths), resulting in the production of large data sets representing the chemical and biochemical wine fingerprint. Multivariate data analysis techniques are then required to handle the large amount of data generated in order to interpret the spectra in a meaningful way in order to develop a specific application. This paper focuses on the developments of sample presentation and main sources of error when vibrational spectroscopy methods are applied in wine analysis. Recent and novel applications will be discussed as examples of these developments. © 2014 Society of Chemical Industry.

Research and Applications of Chemical Sciences in Forestry: Proceedings of the 4th Southern Station Chemical Sciences Meeting

Treesearch

J.A. Vozzo; [Compiler

1994-01-01

This proceedings is the result of 65 scientists representing 34 facilities reported in 28 presentations. As titled, Research and Applications of Chemical Sciences in Forestry, the contributors represent academic, basic, and applied researchers from universities and U.S. Department of Agriculture. Their presence and experience represent a significant showing toward...

Overview of the Meso-NH model version 5.4 and its applications

NASA Astrophysics Data System (ADS)

Lac, Christine; Chaboureau, Jean-Pierre; Masson, Valéry; Pinty, Jean-Pierre; Tulet, Pierre; Escobar, Juan; Leriche, Maud; Barthe, Christelle; Aouizerats, Benjamin; Augros, Clotilde; Aumond, Pierre; Auguste, Franck; Bechtold, Peter; Berthet, Sarah; Bielli, Soline; Bosseur, Frédéric; Caumont, Olivier; Cohard, Jean-Martial; Colin, Jeanne; Couvreux, Fleur; Cuxart, Joan; Delautier, Gaëlle; Dauhut, Thibaut; Ducrocq, Véronique; Filippi, Jean-Baptiste; Gazen, Didier; Geoffroy, Olivier; Gheusi, François; Honnert, Rachel; Lafore, Jean-Philippe; Lebeaupin Brossier, Cindy; Libois, Quentin; Lunet, Thibaut; Mari, Céline; Maric, Tomislav; Mascart, Patrick; Mogé, Maxime; Molinié, Gilles; Nuissier, Olivier; Pantillon, Florian; Peyrillé, Philippe; Pergaud, Julien; Perraud, Emilie; Pianezze, Joris; Redelsperger, Jean-Luc; Ricard, Didier; Richard, Evelyne; Riette, Sébastien; Rodier, Quentin; Schoetter, Robert; Seyfried, Léo; Stein, Joël; Suhre, Karsten; Taufour, Marie; Thouron, Odile; Turner, Sandra; Verrelle, Antoine; Vié, Benoît; Visentin, Florian; Vionnet, Vincent; Wautelet, Philippe

2018-05-01

This paper presents the Meso-NH model version 5.4. Meso-NH is an atmospheric non hydrostatic research model that is applied to a broad range of resolutions, from synoptic to turbulent scales, and is designed for studies of physics and chemistry. It is a limited-area model employing advanced numerical techniques, including monotonic advection schemes for scalar transport and fourth-order centered or odd-order WENO advection schemes for momentum. The model includes state-of-the-art physics parameterization schemes that are important to represent convective-scale phenomena and turbulent eddies, as well as flows at larger scales. In addition, Meso-NH has been expanded to provide capabilities for a range of Earth system prediction applications such as chemistry and aerosols, electricity and lightning, hydrology, wildland fires, volcanic eruptions, and cyclones with ocean coupling. Here, we present the main innovations to the dynamics and physics of the code since the pioneer paper of Lafore et al. (1998) and provide an overview of recent applications and couplings.

A generic motif discovery algorithm for sequential data.

PubMed

Jensen, Kyle L; Styczynski, Mark P; Rigoutsos, Isidore; Stephanopoulos, Gregory N

2006-01-01

Motif discovery in sequential data is a problem of great interest and with many applications. However, previous methods have been unable to combine exhaustive search with complex motif representations and are each typically only applicable to a certain class of problems. Here we present a generic motif discovery algorithm (Gemoda) for sequential data. Gemoda can be applied to any dataset with a sequential character, including both categorical and real-valued data. As we show, Gemoda deterministically discovers motifs that are maximal in composition and length. As well, the algorithm allows any choice of similarity metric for finding motifs. Finally, Gemoda's output motifs are representation-agnostic: they can be represented using regular expressions, position weight matrices or any number of other models for any type of sequential data. We demonstrate a number of applications of the algorithm, including the discovery of motifs in amino acids sequences, a new solution to the (l,d)-motif problem in DNA sequences and the discovery of conserved protein substructures. Gemoda is freely available at http://web.mit.edu/bamel/gemoda

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1992-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.

1993-10-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for land use/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydelko, P.J.; Wilkey, P.L.

1992-01-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way (ROWS) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1) determination of environmentallymore » sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWS; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Clove (Syzygium aromaticum): a precious spice

PubMed Central

Cortés-Rojas, Diego Francisco; de Souza, Claudia Regina Fernandes; Oliveira, Wanderley Pereira

2014-01-01

Clove (Syzygium aromaticum) is one of the most valuable spices that has been used for centuries as food preservative and for many medicinal purposes. Clove is native of Indonesia but nowadays is cultured in several parts of the world including Brazil in the state of Bahia. This plant represents one of the richest source of phenolic compounds such as eugenol, eugenol acetate and gallic acid and posses great potential for pharmaceutical, cosmetic, food and agricultural applications. This review includes the main studies reporting the biological activities of clove and eugenol. The antioxidant and antimicrobial activity of clove is higher than many fruits, vegetables and other spices and should deserve special attention. A new application of clove as larvicidal agent is an interesting strategy to combat dengue which is a serious health problem in Brazil and other tropical countries. Pharmacokinetics and toxicological studies were also mentioned. The different studies reviewed in this work confirm the traditional use of clove as food preservative and medicinal plant standing out the importance of this plant for different applications. PMID:25182278

The application of geography markup language (GML) to the geological sciences

NASA Astrophysics Data System (ADS)

Lake, Ron

2005-11-01

GML 3.0 became an adopted specification of the Open Geospatial Consortium (OGC) in January 2003, and is rapidly emerging as the world standard for the encoding, transport and storage of all forms of geographic information. This paper looks at the application of GML to one of the more challenging areas of automated geography, namely the geological sciences. Specific features of GML of interest to geologists are discussed and then illustrated through a series of geological case studies. We conclude the paper with a discussion of anticipated geological web services that GML will enable. GML is written in XML and makes use of XML Schema for extensibility. It can be used both to represent or model geographic objects and to transport them across the Internet. In this way it serves as the foundation for all manner of geographic web services. Unlike vertical application grammars such as LandXML, GML was intended to define geographic application languages, and hence is applicable to any geographic domain including forestry, environmental sciences, geology and oceanography. This paper provides a review of the basic features of GML that are fundamental to the geological sciences including geometry, coverages, observations, reference systems and temporality. These constructs are then employed in a series of simple geological case studies including structural geological description, surficial geology, representation of geological time scales, mineral occurrences, geohazards and geochemical reconnaissance.

Space Shuttle propulsion performance reconstruction from flight data

NASA Technical Reports Server (NTRS)

Rogers, Robert M.

1989-01-01

The aplication of extended Kalman filtering to estimating Space Shuttle Solid Rocket Booster (SRB) performance, specific impulse, from flight data in a post-flight processing computer program. The flight data used includes inertial platform acceleration, SRB head pressure, and ground based radar tracking data. The key feature in this application is the model used for the SRBs, which represents a reference quasi-static internal ballistics model normalized to the propellant burn depth. Dynamic states of mass overboard and propellant burn depth are included in the filter model to account for real-time deviations from the reference model used. Aerodynamic, plume, wind and main engine uncertainties are included.

Realistic Silver Optical Constants for Plasmonics.

PubMed

Jiang, Yajie; Pillai, Supriya; Green, Martin A

2016-07-29

Silver remains the preferred conductor for optical and near-infrared plasmonics. Many high-profile studies focus exclusively on performance simulation in such applications. Almost invariably, these use silver optical data either from Palik's 1985 handbook or, more frequently, an earlier Johnson and Christy (J&C) tabulation. These data are inconsistent, making it difficult to ascertain the reliability of the simulations. The inconsistency stems from challenges in measuring representative properties of pristine silver, due to tarnishing on air exposure. We demonstrate techniques, including use of silicon-nitride membranes, to access the full capabilities of multiple-angle, spectrometric-ellipsometry to generate an improved data set, representative of overlayer-protected, freshly-deposited silver films on silicon-nitride and glass.

Challenges in Soft Computing: Case Study with Louisville MSD CSO Modeling

NASA Astrophysics Data System (ADS)

Ormsbee, L.; Tufail, M.

2005-12-01

The principal constituents of soft computing include fuzzy logic, neural computing, evolutionary computation, machine learning, and probabilistic reasoning. There are numerous applications of these constituents (both individually and combination of two or more) in the area of water resources and environmental systems. These range from development of data driven models to optimal control strategies to assist in more informed and intelligent decision making process. Availability of data is critical to such applications and having scarce data may lead to models that do not represent the response function over the entire domain. At the same time, too much data has a tendency to lead to over-constraining of the problem. This paper will describe the application of a subset of these soft computing techniques (neural computing and genetic algorithms) to the Beargrass Creek watershed in Louisville, Kentucky. The application include development of inductive models as substitutes for more complex process-based models to predict water quality of key constituents (such as dissolved oxygen) and use them in an optimization framework for optimal load reductions. Such a process will facilitate the development of total maximum daily loads for the impaired water bodies in the watershed. Some of the challenges faced in this application include 1) uncertainty in data sets, 2) model application, and 3) development of cause-and-effect relationships between water quality constituents and watershed parameters through use of inductive models. The paper will discuss these challenges and how they affect the desired goals of the project.

37 CFR 1.31 - Applicant may be represented by one or more patent practitioners or joint inventors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PATENT CASES National Processing Provisions Prosecution of Application and Appointment of Attorney Or Agent § 1.31 Applicant may be represented by one or more patent practitioners or joint inventors. An... by one or more patent practitioners or joint inventors. 1.31 Section 1.31 Patents, Trademarks, and...

Application of shuttle EVA systems to payloads. Volume 1: EVA systems and operational modes description

NASA Technical Reports Server (NTRS)

1976-01-01

Descriptions of the EVA system baselined for the space shuttle program were provided, as well as a compendium of data on available EVA operational modes for payload and orbiter servicing. Operational concepts and techniques to accomplish representative EVA payload tasks are proposed. Some of the subjects discussed include: extravehicular mobility unit, remote manipulator system, airlock, EVA translation aids, restraints, workstations, tools and support equipment.

Maximum Entropy/Optimal Projection (MEOP) control design synthesis: Optimal quantification of the major design tradeoffs

NASA Technical Reports Server (NTRS)

Hyland, D. C.; Bernstein, D. S.

1987-01-01

The underlying philosophy and motivation of the optimal projection/maximum entropy (OP/ME) stochastic modeling and reduced control design methodology for high order systems with parameter uncertainties are discussed. The OP/ME design equations for reduced-order dynamic compensation including the effect of parameter uncertainties are reviewed. The application of the methodology to several Large Space Structures (LSS) problems of representative complexity is illustrated.

Thrust Vector Control for Nuclear Thermal Rockets

NASA Technical Reports Server (NTRS)

Ensworth, Clinton B. F.

2013-01-01

Future space missions may use Nuclear Thermal Rocket (NTR) stages for human and cargo missions to Mars and other destinations. The vehicles are likely to require engine thrust vector control (TVC) to maintain desired flight trajectories. This paper explores requirements and concepts for TVC systems for representative NTR missions. Requirements for TVC systems were derived using 6 degree-of-freedom models of NTR vehicles. Various flight scenarios were evaluated to determine vehicle attitude control needs and to determine the applicability of TVC. Outputs from the models yielded key characteristics including engine gimbal angles, gimbal rates and gimbal actuator power. Additional factors such as engine thrust variability and engine thrust alignment errors were examined for impacts to gimbal requirements. Various technologies are surveyed for TVC systems for the NTR applications. A key factor in technology selection is the unique radiation environment present in NTR stages. Other considerations including mission duration and thermal environments influence the selection of optimal TVC technologies. Candidate technologies are compared to see which technologies, or combinations of technologies best fit the requirements for selected NTR missions. Representative TVC systems are proposed and key properties such as mass and power requirements are defined. The outputs from this effort can be used to refine NTR system sizing models, providing higher fidelity definition for TVC systems for future studies.

Applications of Artificial Neural Networks in Structural Engineering with Emphasis on Continuum Models

NASA Technical Reports Server (NTRS)

Kapania, Rakesh K.; Liu, Youhua

1998-01-01

The use of continuum models for the analysis of discrete built-up complex aerospace structures is an attractive idea especially at the conceptual and preliminary design stages. But the diversity of available continuum models and hard-to-use qualities of these models have prevented them from finding wide applications. In this regard, Artificial Neural Networks (ANN or NN) may have a great potential as these networks are universal approximators that can realize any continuous mapping, and can provide general mechanisms for building models from data whose input-output relationship can be highly nonlinear. The ultimate aim of the present work is to be able to build high fidelity continuum models for complex aerospace structures using the ANN. As a first step, the concepts and features of ANN are familiarized through the MATLAB NN Toolbox by simulating some representative mapping examples, including some problems in structural engineering. Then some further aspects and lessons learned about the NN training are discussed, including the performances of Feed-Forward and Radial Basis Function NN when dealing with noise-polluted data and the technique of cross-validation. Finally, as an example of using NN in continuum models, a lattice structure with repeating cells is represented by a continuum beam whose properties are provided by neural networks.

A Proxy Design to Leverage the Interconnection of CoAP Wireless Sensor Networks with Web Applications

PubMed Central

Ludovici, Alessandro; Calveras, Anna

2015-01-01

In this paper, we present the design of a Constrained Application Protocol (CoAP) proxy able to interconnect Web applications based on Hypertext Transfer Protocol (HTTP) and WebSocket with CoAP based Wireless Sensor Networks. Sensor networks are commonly used to monitor and control physical objects or environments. Smart Cities represent applications of such a nature. Wireless Sensor Networks gather data from their surroundings and send them to a remote application. This data flow may be short or long lived. The traditional HTTP long-polling used by Web applications may not be adequate in long-term communications. To overcome this problem, we include the WebSocket protocol in the design of the CoAP proxy. We evaluate the performance of the CoAP proxy in terms of latency and memory consumption. The tests consider long and short-lived communications. In both cases, we evaluate the performance obtained by the CoAP proxy according to the use of WebSocket and HTTP long-polling. PMID:25585107

Liquid chromatography coupled to on-line post column derivatization for the determination of organic compounds: a review on instrumentation and chemistries.

PubMed

Zacharis, Constantinos K; Tzanavaras, Paraskevas D

2013-10-10

Analytical derivatization either in pre or post column modes is one of the most widely used sample pretreatment techniques coupled to liquid chromatography. In the present review article we selected to discuss the post column derivatization mode for the analysis of organic compounds. The first part of the review focuses to the instrumentation of post-column setups including not only fundamental components such as pumps and reactors but also less common parts such as static mixers and back-pressure regulators; the second part of the article discusses the most popular "chemistries" that are involved in post column applications, including reagent-less approaches and new sensing platforms such as the popular gold nanoparticles. Some representative recent applications are also presented as tables. Copyright © 2013 Elsevier B.V. All rights reserved.

Cognitive engineering models in space systems

NASA Technical Reports Server (NTRS)

Mitchell, Christine M.

1992-01-01

NASA space systems, including mission operations on the ground and in space, are complex, dynamic, predominantly automated systems in which the human operator is a supervisory controller. The human operator monitors and fine-tunes computer-based control systems and is responsible for ensuring safe and efficient system operation. In such systems, the potential consequences of human mistakes and errors may be very large, and low probability of such events is likely. Thus, models of cognitive functions in complex systems are needed to describe human performance and form the theoretical basis of operator workstation design, including displays, controls, and decision support aids. The operator function model represents normative operator behavior-expected operator activities given current system state. The extension of the theoretical structure of the operator function model and its application to NASA Johnson mission operations and space station applications is discussed.

mHealth Education Applications Along the Cancer Continuum.

PubMed

Davis, Sharon Watkins; Oakley-Girvan, Ingrid

2015-06-01

The majority of adults worldwide own a mobile phone, including those in under-resourced communities. Mobile health (mhealth) education technologies present a promising mechanism for improving cancer prevention, treatment, and follow-up. The purpose of this study was to summarize the literature related to mobile phone (mhealth) applications for patient education specific to cancer and identify current recommendations from randomized studies. In particular, we were interested in identifying mobile phone applications along the cancer continuum, from cancer prevention to survivorship. The authors identified 28 articles reporting on mobile applications for patients related to cancer. Articles were identified in all categories along the cancer continuum, including health professional involvement in application development. Of these, six involved direct patient education, and eight focused on improving patient/professional communication and patient self-management. However, only six of the studies were randomized interventions. The potential for mobile applications to help overcome the "health care gap" has not yet been realized in the studies from the USA that were reviewed for this paper. However, early recommendations are emerging that support the use of mHealth communications to change behaviors for cancer prevention, early detection, and symptom management and improved patient-provider communication. Recommendations include short messages, use of multiple modalities as patient characteristics dictate comfort with mHealth communication, and the inclusion of patients and health professionals to develop and test applications. Tailoring mHealth to particular cultures, languages, and ethnic groups may also represent a unique possibility to provide accessible information and education at minimal cost for under-resourced communities and individuals.

Polyesters from microorganisms.

PubMed

Kim, Y B; Lenz, R W

2001-01-01

Bacterial polyesters have been found to have useful properties for applications as thermoplastics, elastomers, and adhesives and are biodegradable and biocompatible. Poly(3-hydroxyalkanoates) (PHAs) and poly(beta-malate) are the most representative polyesters synthesized by microorganisms. PHAs containing a wide variety of repeating units can be produced by bacteria, including those containing many types of pendant functional groups which can be synthesized by microorganisms that are grown on unnatural organic substrates. Poly(beta-malate) is of interest primarily for medical applications, especially for drug delivery systems. In this chapter, the bacterial production and properties of poly(3-hydroxyalkanoates) and poly(beta-malate) are described with emphasis on the former.

Engineering nucleases for gene targeting: safety and regulatory considerations.

PubMed

Pauwels, Katia; Podevin, Nancy; Breyer, Didier; Carroll, Dana; Herman, Philippe

2014-01-25

Nuclease-based gene targeting (NBGT) represents a significant breakthrough in targeted genome editing since it is applicable from single-celled protozoa to human, including several species of economic importance. Along with the fast progress in NBGT and the increasing availability of customized nucleases, more data are available about off-target effects associated with the use of this approach. We discuss how NBGT may offer a new perspective for genetic modification, we address some aspects crucial for a safety improvement of the corresponding techniques and we also briefly relate the use of NBGT applications and products to the regulatory oversight. Copyright © 2013 Elsevier B.V. All rights reserved.

Application of Mouse Models to Research in Hearing and Balance.

PubMed

Ohlemiller, Kevin K; Jones, Sherri M; Johnson, Kenneth R

2016-12-01

Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.

Fingertip-shaped optical tactile sensor for robotic applications

NASA Technical Reports Server (NTRS)

Begej, Stefan

1988-01-01

Progress is described regarding the development of a high-density, fiber-optic, fingertip-shaped tactile sensor specifically designed for application to dexterous robotics. The sensor operates on optical principles involving the frustration of total internal reflection at a waveguide/elastomer interface and generates a grey-scale tactile image that represents the normal forces of contact. The sensor contains 256 taxels (sensing sites) distributed in a dual-density pattern that includes a tactile fovea near the tip which measures 13 mm x 13 mm and contains 169 taxels. The details regarding the design and construction of this tactile sensor are presented, in addition to photographs of tactile imprints.

Applications of the hybrid coordinate method to the TOPS autopilot

NASA Technical Reports Server (NTRS)

Fleischer, G. E.

1978-01-01

Preliminary results are presented from the application of the hybrid coordinate method to modeling TOPS (thermoelectric outer planet spacecraft) structural dynamics. Computer simulated responses of the vehicle are included which illustrate the interaction of relatively flexible appendages with an autopilot control system. Comparisons were made between simplified single-axis models of the control loop, with spacecraft flexibility represented by hinged rigid bodies, and a very detailed three-axis spacecraft model whose flexible portions are described by modal coordinates. While single-axis system, root loci provided reasonable qualitative indications of stability margins in this case, they were quantitatively optimistic when matched against responses of the detailed model.

On Representative Spaceflight Instrument and Associated Instrument Sensor Web Framework

NASA Technical Reports Server (NTRS)

Kizhner, Semion; Patel, Umeshkumar; Vootukuru, Meg

2007-01-01

Sensor Web-based adaptation and sharing of space flight mission resources, including those of the Space-Ground and Control-User communication segment, could greatly benefit from utilization of heritage Internet Protocols and devices applied for Spaceflight (SpaceIP). This had been successfully demonstrated by a few recent spaceflight experiments. However, while terrestrial applications of Internet protocols are well developed and understood (mostly due to billions of dollars in investments by the military and industry), the spaceflight application of Internet protocols is still in its infancy. Progress in the developments of SpaceIP-enabled instrument components will largely determine the SpaceIP utilization of those investments and acceptance in years to come. Likewise SpaceIP, the development of commercial real-time and instrument colocated computational resources, data compression and storage, can be enabled on-board a spacecraft and, in turn, support a powerful application to Sensor Web-based design of a spaceflight instrument. Sensor Web-enabled reconfiguration and adaptation of structures for hardware resources and information systems will commence application of Field Programmable Arrays (FPGA) and other aerospace programmable logic devices for what this technology was intended. These are a few obvious potential benefits of Sensor Web technologies for spaceflight applications. However, they are still waiting to be explored. This is because there is a need for a new approach to spaceflight instrumentation in order to make these mature sensor web technologies applicable for spaceflight. In this paper we present an approach in developing related and enabling spaceflight instrument-level technologies based on the new concept of a representative spaceflight Instrument Sensor Web (ISW).

Region Templates: Data Representation and Management for High-Throughput Image Analysis

PubMed Central

Pan, Tony; Kurc, Tahsin; Kong, Jun; Cooper, Lee; Klasky, Scott; Saltz, Joel

2015-01-01

We introduce a region template abstraction and framework for the efficient storage, management and processing of common data types in analysis of large datasets of high resolution images on clusters of hybrid computing nodes. The region template abstraction provides a generic container template for common data structures, such as points, arrays, regions, and object sets, within a spatial and temporal bounding box. It allows for different data management strategies and I/O implementations, while providing a homogeneous, unified interface to applications for data storage and retrieval. A region template application is represented as a hierarchical dataflow in which each computing stage may be represented as another dataflow of finer-grain tasks. The execution of the application is coordinated by a runtime system that implements optimizations for hybrid machines, including performance-aware scheduling for maximizing the utilization of computing devices and techniques to reduce the impact of data transfers between CPUs and GPUs. An experimental evaluation on a state-of-the-art hybrid cluster using a microscopy imaging application shows that the abstraction adds negligible overhead (about 3%) and achieves good scalability and high data transfer rates. Optimizations in a high speed disk based storage implementation of the abstraction to support asynchronous data transfers and computation result in an application performance gain of about 1.13×. Finally, a processing rate of 11,730 4K×4K tiles per minute was achieved for the microscopy imaging application on a cluster with 100 nodes (300 GPUs and 1,200 CPU cores). This computation rate enables studies with very large datasets. PMID:26139953

SBRML: a markup language for associating systems biology data with models.

PubMed

Dada, Joseph O; Spasić, Irena; Paton, Norman W; Mendes, Pedro

2010-04-01

Research in systems biology is carried out through a combination of experiments and models. Several data standards have been adopted for representing models (Systems Biology Markup Language) and various types of relevant experimental data (such as FuGE and those of the Proteomics Standards Initiative). However, until now, there has been no standard way to associate a model and its entities to the corresponding datasets, or vice versa. Such a standard would provide a means to represent computational simulation results as well as to frame experimental data in the context of a particular model. Target applications include model-driven data analysis, parameter estimation, and sharing and archiving model simulations. We propose the Systems Biology Results Markup Language (SBRML), an XML-based language that associates a model with several datasets. Each dataset is represented as a series of values associated with model variables, and their corresponding parameter values. SBRML provides a flexible way of indexing the results to model parameter values, which supports both spreadsheet-like data and multidimensional data cubes. We present and discuss several examples of SBRML usage in applications such as enzyme kinetics, microarray gene expression and various types of simulation results. The XML Schema file for SBRML is available at http://www.comp-sys-bio.org/SBRML under the Academic Free License (AFL) v3.0.

Mobile Applications for Type 2 Diabetes Risk Estimation: a Systematic Review.

PubMed

Fijacko, Nino; Brzan, Petra Povalej; Stiglic, Gregor

2015-10-01

Screening for chronical diseases like type 2 diabetes can be done using different methods and various risk tests. This study present a review of type 2 diabetes risk estimation mobile applications focusing on their functionality and availability of information on the underlying risk calculators. Only 9 out of 31 reviewed mobile applications, featured in three major mobile application stores, disclosed the name of risk calculator used for assessing the risk of type 2 diabetes. Even more concerning, none of the reviewed applications mentioned that they are collecting the data from users to improve the performance of their risk estimation calculators or offer users the descriptive statistics of the results from users that already used the application. For that purpose the questionnaires used for calculation of risk should be upgraded by including the information on the most recent blood sugar level measurements from users. Although mobile applications represent a great future potential for health applications, developers still do not put enough emphasis on informing the user of the underlying methods used to estimate the risk for a specific clinical condition.

SpectralNET – an application for spectral graph analysis and visualization

PubMed Central

Forman, Joshua J; Clemons, Paul A; Schreiber, Stuart L; Haggarty, Stephen J

2005-01-01

Background Graph theory provides a computational framework for modeling a variety of datasets including those emerging from genomics, proteomics, and chemical genetics. Networks of genes, proteins, small molecules, or other objects of study can be represented as graphs of nodes (vertices) and interactions (edges) that can carry different weights. SpectralNET is a flexible application for analyzing and visualizing these biological and chemical networks. Results Available both as a standalone .NET executable and as an ASP.NET web application, SpectralNET was designed specifically with the analysis of graph-theoretic metrics in mind, a computational task not easily accessible using currently available applications. Users can choose either to upload a network for analysis using a variety of input formats, or to have SpectralNET generate an idealized random network for comparison to a real-world dataset. Whichever graph-generation method is used, SpectralNET displays detailed information about each connected component of the graph, including graphs of degree distribution, clustering coefficient by degree, and average distance by degree. In addition, extensive information about the selected vertex is shown, including degree, clustering coefficient, various distance metrics, and the corresponding components of the adjacency, Laplacian, and normalized Laplacian eigenvectors. SpectralNET also displays several graph visualizations, including a linear dimensionality reduction for uploaded datasets (Principal Components Analysis) and a non-linear dimensionality reduction that provides an elegant view of global graph structure (Laplacian eigenvectors). Conclusion SpectralNET provides an easily accessible means of analyzing graph-theoretic metrics for data modeling and dimensionality reduction. SpectralNET is publicly available as both a .NET application and an ASP.NET web application from . Source code is available upon request. PMID:16236170

SpectralNET--an application for spectral graph analysis and visualization.

PubMed

Forman, Joshua J; Clemons, Paul A; Schreiber, Stuart L; Haggarty, Stephen J

2005-10-19

Graph theory provides a computational framework for modeling a variety of datasets including those emerging from genomics, proteomics, and chemical genetics. Networks of genes, proteins, small molecules, or other objects of study can be represented as graphs of nodes (vertices) and interactions (edges) that can carry different weights. SpectralNET is a flexible application for analyzing and visualizing these biological and chemical networks. Available both as a standalone .NET executable and as an ASP.NET web application, SpectralNET was designed specifically with the analysis of graph-theoretic metrics in mind, a computational task not easily accessible using currently available applications. Users can choose either to upload a network for analysis using a variety of input formats, or to have SpectralNET generate an idealized random network for comparison to a real-world dataset. Whichever graph-generation method is used, SpectralNET displays detailed information about each connected component of the graph, including graphs of degree distribution, clustering coefficient by degree, and average distance by degree. In addition, extensive information about the selected vertex is shown, including degree, clustering coefficient, various distance metrics, and the corresponding components of the adjacency, Laplacian, and normalized Laplacian eigenvectors. SpectralNET also displays several graph visualizations, including a linear dimensionality reduction for uploaded datasets (Principal Components Analysis) and a non-linear dimensionality reduction that provides an elegant view of global graph structure (Laplacian eigenvectors). SpectralNET provides an easily accessible means of analyzing graph-theoretic metrics for data modeling and dimensionality reduction. SpectralNET is publicly available as both a .NET application and an ASP.NET web application from http://chembank.broad.harvard.edu/resources/. Source code is available upon request.

Factors associated with successful matching to dermatology residency programs by reapplicants and other applicants who previously graduated from medical school.

PubMed

Stratman, Erik J; Ness, Rachel M

2011-02-01

To identify factors associated with and not associated with successful matching and matriculation (hereinafter "matching") to dermatology residency programs for applicants who previously graduated from medical school and to distinguish which factors are within applicants' control. Observational cohort study. Six accredited academic dermatology residency training programs in the United States. A total of 221 residency applicants who previously graduated from medical school and who applied through standardized electronic application to 1 or more of the participating residency training programs. Matriculation to a dermatology residency program by August 2008 following the 2006 residency application period. Forty-six of 221 former medical school graduates included in this study matched to a dermatology residency program. Factors strongly associated with matching included United States Medical Licensing Examination Step 3 score; submission of letters written by dermatologists from institutions that train dermatology residents; completion of preliminary medicine internships rather than transitional or other internship types; listing of research experience; publishing of medical manuscripts; and completion of non-Accreditation Council for Graduate Medical Examination dermatology fellowships. Factors not associated with increased matching included volunteer work; PhD status; sex; number of posters or presentations at dermatology conferences; quality of journal publications; and first authorship. Most successful applicants limited personal statements to 1 page and did not mention previously failing to match. The study sample represented at least 86% of such nontraditional applicants who matched in 2006. For candidates seeking to match into dermatology residency programs after graduating from medical school, there are factors within their control that are associated with higher rates of match success. This study provides evidence to assist mentors who counsel such candidates. ©2011 American Medical Association. All rights reserved.

Applications of Metabolomics in Cancer Studies.

PubMed

Armitage, Emily Grace; Ciborowski, Michal

2017-01-01

Since the start of metabolomics as a field of research, the number of studies related to cancer has grown to such an extent that cancer metabolomics now represents its own discipline. In this chapter, the applications of metabolomics in cancer studies are explored. Different approaches and analytical platforms can be employed for the analysis of samples depending on the goal of the study and the aspects of the cancer metabolome being investigated. Analyses have concerned a range of cancers including lung, colorectal, bladder, breast, gastric, oesophageal and thyroid, amongst others. Developments in these strategies and methodologies that have been applied are discussed, in addition to exemplifying the use of cancer metabolomics in the discovery of biomarkers and in the assessment of therapy (both pharmaceutical and nutraceutical). Finally, the application of cancer metabolomics in personalised medicine is presented.

Application of IFT and SPSA to servo system control.

PubMed

Rădac, Mircea-Bogdan; Precup, Radu-Emil; Petriu, Emil M; Preitl, Stefan

2011-12-01

This paper treats the application of two data-based model-free gradient-based stochastic optimization techniques, i.e., iterative feedback tuning (IFT) and simultaneous perturbation stochastic approximation (SPSA), to servo system control. The representative case of controlled processes modeled by second-order systems with an integral component is discussed. New IFT and SPSA algorithms are suggested to tune the parameters of the state feedback controllers with an integrator in the linear-quadratic-Gaussian (LQG) problem formulation. An implementation case study concerning the LQG-based design of an angular position controller for a direct current servo system laboratory equipment is included to highlight the pros and cons of IFT and SPSA from an application's point of view. The comparison of IFT and SPSA algorithms is focused on an insight into their implementation.

The design and application of a Transportable Inference Engine (TIE1)

NASA Technical Reports Server (NTRS)

Mclean, David R.

1986-01-01

A Transportable Inference Engine (TIE1) system has been developed by the author as part of the Interactive Experimenter Planning System (IEPS) task which is involved with developing expert systems in support of the Spacecraft Control Programs Branch at Goddard Space Flight Center in Greenbelt, Maryland. Unlike traditional inference engines, TIE1 is written in the C programming language. In the TIE1 system, knowledge is represented by a hierarchical network of objects which have rule frames. The TIE1 search algorithm uses a set of strategies, including backward chaining, to obtain the values of goals. The application of TIE1 to a spacecraft scheduling problem is described. This application involves the development of a strategies interpreter which uses TIE1 to do constraint checking.

A High-Average-Power Free Electron Laser for Microfabrication and Surface Applications

NASA Technical Reports Server (NTRS)

Dylla, H. F.; Benson, S.; Bisognano, J.; Bohn, C. L.; Cardman, L.; Engwall, D.; Fugitt, J.; Jordan, K.; Kehne, D.; Li, Z.;

Self-organization in neural networks - Applications in structural optimization

NASA Technical Reports Server (NTRS)

Hajela, Prabhat; Fu, B.; Berke, Laszlo

1993-01-01

The present paper discusses the applicability of ART (Adaptive Resonance Theory) networks, and the Hopfield and Elastic networks, in problems of structural analysis and design. A characteristic of these network architectures is the ability to classify patterns presented as inputs into specific categories. The categories may themselves represent distinct procedural solution strategies. The paper shows how this property can be adapted in the structural analysis and design problem. A second application is the use of Hopfield and Elastic networks in optimization problems. Of particular interest are problems characterized by the presence of discrete and integer design variables. The parallel computing architecture that is typical of neural networks is shown to be effective in such problems. Results of preliminary implementations in structural design problems are also included in the paper.

Graphene-Based Flexible and Stretchable Electronics.

PubMed

Jang, Houk; Park, Yong Ju; Chen, Xiang; Das, Tanmoy; Kim, Min-Seok; Ahn, Jong-Hyun

2016-06-01

Graphene provides outstanding properties that can be integrated into various flexible and stretchable electronic devices in a conventional, scalable fashion. The mechanical, electrical, and optical properties of graphene make it an attractive candidate for applications in electronics, energy-harvesting devices, sensors, and other systems. Recent research progress on graphene-based flexible and stretchable electronics is reviewed here. The production and fabrication methods used for target device applications are first briefly discussed. Then, the various types of flexible and stretchable electronic devices that are enabled by graphene are discussed, including logic devices, energy-harvesting devices, sensors, and bioinspired devices. The results represent important steps in the development of graphene-based electronics that could find applications in the area of flexible and stretchable electronics. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pediatric echocardiography: new developments and applications.

PubMed

Ge, Shuping

2013-04-01

In this Special Issue of the Journal, 6 review articles that represent the new developments and applications of echocardiography for diagnosis and assessment of congenital heart disease from fetus to adult are included. The goal is to provide an updated review of the evidence for the current and potential use of some of the new methodologies, i.e. fetal echocardiography, tissue Doppler imaging, strain imaging by speckle tracking imaging, ventricular synchrony, quantification using real time three-dimensional (3D) echocardiography, and 3D echocardiography for adults with congenital heart disease. We hope this effort will provide an impetus for more investigation and ultimately clinical application of these new methodologies to improve the care of those with congenital and acquired heart diseases in the pediatric population and beyond. © 2013, Wiley Periodicals, Inc.

A high-average-power FEL for industrial applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dylla, H.F.; Benson, S.; Bisognano, J.

1995-12-31

CEBAF has developed a comprehensive conceptual design of an industrial user facility based on a kilowatt UV (150-1000 nm) and IR (2-25 micron) FEL driven by a recirculating, energy-recovering 200 MeV superconducting radio-frequency (SRF) accelerator. FEL users{endash}CEBAF`s partners in the Laser Processing Consortium, including AT&T, DuPont, IBM, Northrop-Grumman, 3M, and Xerox{endash}plan to develop applications such as polymer surface processing, metals and ceramics micromachining, and metal surface processing, with the overall effort leading to later scale-up to industrial systems at 50-100 kW. Representative applications are described. The proposed high-average-power FEL overcomes limitations of conventional laser sources in available power, cost-effectiveness, tunabilitymore » and pulse structure. 4 refs., 3 figs., 2 tabs.« less

Improved motors for utility applications: Volume 6, Squirrel-cage rotor analysis: Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Griffith, J.W.; McCoy, R.M.

1986-11-01

An analysis of squirrel cage induction motor rotors was undertaken in response to an Industry Assessment Study finding 10% of motor failures to be rotor related. The analysis focuses on evaluating rotor design life. The evaluation combines state-of-the-art electromagnetic, thermal, and structural solution techniques into an integrated analysis and presents a simple summary. Finite element techniques are central tools in the analysis. The analysis is applied to a specific forced draft fan drive design. Fans as a category of application have a higher failure rate than other categories of power station auxiliary motor applications. Forced-draft fan drives are one ofmore » the major fan drives which accelerate a relatively high value of rotor load inertia. Various starting and operating conditions are studied for this forced-draft fan drive motor including a representative application duty cycle.« less

Research and application of microbial enzymes--India's contribution.

PubMed

Chand, Subhash; Mishra, Prashant

2003-01-01

Enzymes have attracted the attention of scientists world over due to their wide range of physiological, analytical and industrial applications. Although enzymes have been isolated, purified and studied from microbial, animal and plant sources, microorganisms represent the most common source of enzymes due to their broad biochemical diversity, feasibility of mass culture and ease of genetic manipulation. With the advent of molecular biology techniques, a number of genes of industrially important enzymes has been cloned and expressed in order to improve the production of enzymes, substrate utilization and other commercially useful properties. Special attention has been focused on enzymes isolated from thermophiles due to their inherent stability and industrial applications. In addition, a variety of methods have been employed to modify enzymes for their industrial usage including strain improvement, chemical modifications, modification of reaction environment, immobilization and protein engineering. A wide range of applications of enzymes in different bioprocess industries is discussed.

Laser ablation surface-enhanced Raman microspectroscopy.

PubMed

Londero, Pablo S; Lombardi, John R; Leona, Marco

2013-06-04

Improved identification of trace organic compounds in complex matrixes is critical for a variety of fields such as material science, heritage science, and forensics. Surface-enhanced Raman scattering (SERS) is a vibrational spectroscopy technique that can attain single-molecule sensitivity and has been shown to complement mass spectrometry, but lacks widespread application without a robust method that utilizes the effect. We demonstrate a new, highly sensitive, and widely applicable approach to SERS analysis based on laser ablation in the presence of a tailored plasmonic substrate. We analyze several challenging compounds, including non-water-soluble pigments and dyed leather from an ancient Egyptian chariot, achieving sensitivity as high as 120 amol for a 1:1 signal-to-noise ratio and 5 μm spatial resolution. This represents orders of magnitude improvement in spatial resolution and sensitivity compared to those of other SERS approaches intended for widespread application, greatly increasing the applicability of SERS.

Scientific Visualization Made Easy for the Scientist

NASA Astrophysics Data System (ADS)

Westerhoff, M.; Henderson, B.

2002-12-01

amirar is an application program used in creating 3D visualizations and geometric models of 3D image data sets from various application areas, e.g. medicine, biology, biochemistry, chemistry, physics, and engineering. It has demonstrated significant adoption in the market place since becoming commercially available in 2000. The rapid adoption has expanded the features being requested by the user base and broadened the scope of the amira product offering. The amira product offering includes amira Standard, amiraDevT, used to extend the product capabilities by users, amiraMolT, used for molecular visualization, amiraDeconvT, used to improve quality of image data, and amiraVRT, used in immersive VR environments. amira allows the user to construct a visualization tailored to his or her needs without requiring any programming knowledge. It also allows 3D objects to be represented as grids suitable for numerical simulations, notably as triangular surfaces and volumetric tetrahedral grids. The amira application also provides methods to generate such grids from voxel data representing an image volume, and it includes a general-purpose interactive 3D viewer. amiraDev provides an application-programming interface (API) that allows the user to add new components by C++ programming. amira supports many import formats including a 'raw' format allowing immediate access to your native uniform data sets. amira uses the power and speed of the OpenGLr and Open InventorT graphics libraries and 3D graphics accelerators to allow you to access over 145 modules, enabling you to process, probe, analyze and visualize your data. The amiraMolT extension adds powerful tools for molecular visualization to the existing amira platform. amiraMolT contains support for standard molecular file formats, tools for visualization and analysis of static molecules as well as molecular trajectories (time series). amiraDeconv adds tools for the deconvolution of 3D microscopic images. Deconvolution is the process of increasing image quality and resolution by computationally compensating artifacts of the recording process. amiraDeconv supports 3D wide field microscopy as well as 3D confocal microscopy. It offers both non-blind and blind image deconvolution algorithms. Non-blind deconvolution uses an individual measured point spread function, while non-blind algorithms work on the basis of only a few recording parameters (like numerical aperture or zoom factor). amiraVR is a specialized and extended version of the amira visualization system which is dedicated for use in immersive installations, such as large-screen stereoscopic projections, CAVEr or Holobenchr systems. Among others, it supports multi-threaded multi-pipe rendering, head-tracking, advanced 3D interaction concepts, and 3D menus allowing interaction with any amira object in the same way as on the desktop. With its unique set of features, amiraVR represents both a VR (Virtual Reality) ready application for scientific and medical visualization in immersive environments, and a development platform that allows building VR applications.

The development of a clinical outcomes survey research application: Assessment Center.

PubMed

Gershon, Richard; Rothrock, Nan E; Hanrahan, Rachel T; Jansky, Liz J; Harniss, Mark; Riley, William

2010-06-01

The National Institutes of Health sponsored Patient-Reported Outcome Measurement Information System (PROMIS) aimed to create item banks and computerized adaptive tests (CATs) across multiple domains for individuals with a range of chronic diseases. Web-based software was created to enable a researcher to create study-specific Websites that could administer PROMIS CATs and other instruments to research participants or clinical samples. This paper outlines the process used to develop a user-friendly, free, Web-based resource (Assessment Center) for storage, retrieval, organization, sharing, and administration of patient-reported outcomes (PRO) instruments. Joint Application Design (JAD) sessions were conducted with representatives from numerous institutions in order to supply a general wish list of features. Use Cases were then written to ensure that end user expectations matched programmer specifications. Program development included daily programmer "scrum" sessions, weekly Usability Acceptability Testing (UAT) and continuous Quality Assurance (QA) activities pre- and post-release. Assessment Center includes features that promote instrument development including item histories, data management, and storage of statistical analysis results. This case study of software development highlights the collection and incorporation of user input throughout the development process. Potential future applications of Assessment Center in clinical research are discussed.

Applications for Subvocal Speech

NASA Technical Reports Server (NTRS)

Jorgensen, Charles; Betts, Bradley

2007-01-01

A research and development effort now underway is directed toward the use of subvocal speech for communication in settings in which (1) acoustic noise could interfere excessively with ordinary vocal communication and/or (2) acoustic silence or secrecy of communication is required. By "subvocal speech" is meant sub-audible electromyographic (EMG) signals, associated with speech, that are acquired from the surface of the larynx and lingual areas of the throat. Topics addressed in this effort include recognition of the sub-vocal EMG signals that represent specific original words or phrases; transformation (including encoding and/or enciphering) of the signals into forms that are less vulnerable to distortion, degradation, and/or interception; and reconstruction of the original words or phrases at the receiving end of a communication link. Potential applications include ordinary verbal communications among hazardous- material-cleanup workers in protective suits, workers in noisy environments, divers, and firefighters, and secret communications among law-enforcement officers and military personnel in combat and other confrontational situations.

Building a Network of Internships for a Diverse Geoscience Community

NASA Astrophysics Data System (ADS)

Sloan, V.; Haacker-Santos, R.; Pandya, R.

2011-12-01

Individual undergraduate internship programs, however effective, are not sufficient to address the lack of diversity in the geoscience workforce. Rather than competing with each other for a small pool of students from historically under-represented groups, REU and internship programs might share recruiting efforts and application processes. For example, in 2011, the RESESS program at UNAVCO and the SOARS program at UCAR shared recruiting websites and advertising. This contributed to a substantial increase in the number of applicants to the RESESS program, the majority of which were from historically under-represented groups. RESESS and SOARS shared qualified applications with other REU/internship programs and helped several additional minority students secure summer internships. RESESS and SOARS also leveraged their geographic proximity to pool resources for community building activities, a two-day science field trip, a weekly writing workshop, and our final poster session. This provided our interns with an expanded network of peers and gave our staff opportunities to work together on planning. Recently we have reached out to include other programs and agencies in activities for our interns, such as mentoring high-school students, leading outreach to elementary school students, and exposing our interns to geoscience careers options and graduate schools. Informal feedback from students suggests that they value these interactions and appreciate learning with interns from partner programs. Through this work, we are building a network of program managers who support one another professionally and share effective strategies. We would like to expand that network, and future plans include a workshop with university partners and an expanded list of REU programs to explore further collaborations.

Constructing diagnostic likelihood: clinical decisions using subjective versus statistical probability.

PubMed

Kinnear, John; Jackson, Ruth

2017-07-01

Although physicians are highly trained in the application of evidence-based medicine, and are assumed to make rational decisions, there is evidence that their decision making is prone to biases. One of the biases that has been shown to affect accuracy of judgements is that of representativeness and base-rate neglect, where the saliency of a person's features leads to overestimation of their likelihood of belonging to a group. This results in the substitution of 'subjective' probability for statistical probability. This study examines clinicians' propensity to make estimations of subjective probability when presented with clinical information that is considered typical of a medical condition. The strength of the representativeness bias is tested by presenting choices in textual and graphic form. Understanding of statistical probability is also tested by omitting all clinical information. For the questions that included clinical information, 46.7% and 45.5% of clinicians made judgements of statistical probability, respectively. Where the question omitted clinical information, 79.9% of clinicians made a judgement consistent with statistical probability. There was a statistically significant difference in responses to the questions with and without representativeness information (χ2 (1, n=254)=54.45, p<0.0001). Physicians are strongly influenced by a representativeness bias, leading to base-rate neglect, even though they understand the application of statistical probability. One of the causes for this representativeness bias may be the way clinical medicine is taught where stereotypic presentations are emphasised in diagnostic decision making. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Investigating Advances in the Acquisition of Systems Based on Open Architecture and Open Source Software

DTIC Science & Technology

2011-08-01

dominates the global mobile application market and mobile computing software ecosystems. But overall, OA systems are not necessarily excluded from...License 3.0 (OSL)  Corel Transactional License ( CTL ) The licenses were chosen to represent a variety of kinds of licenses, and include one...proprietary ( CTL ), three academic (Apache, BSD, MIT), and six reciprocal licenses (CPL, EPL, GPL, LGPL, MPL, OSL) that take varying approaches in

Spinoff 1999

NASA Technical Reports Server (NTRS)

1999-01-01

A survey is presented of NASA-developed technologies and systems that were reaching commercial application in the course of 1999. Attention is given to the contributions of each major NASA Research Center. Representative 'spinoff' technologies include the predictive AI engine monitoring system EMPAS, the GPS-based Wide Area Augmentation System for aircraft navigation, a CMOS-Active Pixel Sensor camera-on-a-chip, a marine spectroradiometer, portable fuel cells, hyperspectral camera technology, and a rapid-prototyping process for ceramic components.

Thin family: a new barcode concept

NASA Astrophysics Data System (ADS)

Allais, David C.

1991-02-01

This paper describes a new space-efficient family of thin bar code symbologies which are appropriate for representing small amounts of information. The proposed structure is 30 to 50 percent more compact than the narrowest existing bar code when 12 or fewer bits of information are to be encoded in each symbol. Potential applications for these symbologies include menus catalogs automated test and survey scoring and biological research such as the tracking of honey bees.

Fracture toughness testing data. A bibliography

NASA Technical Reports Server (NTRS)

Carpenter, J. L., Jr.; Moya, N.; Stuhrke, W. F.

1975-01-01

This bibliography is comprised of approximately 800 reference citations related to the mechanics of failure in aerospace structures. Most of the references are for documents that include fracture toughness testing data and its application or documents on the availability and usefulness of fracture mechanics analysis methodology. The bibliography represents a search of the literature published in the period April 1962 through April 1974 and is largely limited to documents published in the United States.

Orbiter/Space lab momentum management for POP orientations

NASA Technical Reports Server (NTRS)

Cox, J. W.

1974-01-01

An angular momentum management scheme applicable to the orbiter/spacelab is described. The basis of the scheme is to periodically maneuver the vehicle through a small angle thereby using the gravity gradient torque to dump momentum from the control moment gyro (CMG) control system. The orbiter is operated with its principal vehicle axis perpendicular to the orbital plane. Numerous case runs were conducted on the hybrid simulation and representative cases are included.

Enhancing HIV Prevention Among Young Men Who Have Sex With Men: A Systematic Review of HIV Behavioral Interventions for Young Gay and Bisexual Men.

PubMed

Hergenrather, Kenneth C; Emmanuel, Diona; Durant, Sarah; Rhodes, Scott D

2016-06-01

Men who have sex with men (MSM) represent 64.0% of people living with HIV (PLWH) over the age of 13 years. Young men who have sex with men (YMSM) are particularly affected by HIV/AIDS; the rate of HIV infection for YMSM between the ages of 13 and 24 represents 72.0% of new infections among youth. To understand the current state of the science meant to prevent HIV for YMSM, we reviewed studies of HIV behavioral prevention interventions for YMSM. Five literature databases were searched, from their inception through October 2015, using key words associated with HIV prevention intervention evaluation studies for YMSM. The review criteria included behavioral HIV/AIDS prevention interventions, articles published in English-language peer-reviewed journals, YMSM between 13 and 24 years of age, and longitudinal repeated measures design. A total of 15 YMSM behavioral HIV prevention intervention studies were identified that met inclusion criteria and reported statistically significant findings. Common outcomes included unprotected sexual intercourse, HIV/AIDS risk behavior, condom use, HIV testing, safer sex attitude, and HIV prevention communication. Participant age, representation of Black/African American YMSM, application of theoretical and model underpinnings, congruence of assessment measures used, follow-up assessment times, and application of process evaluation were inconsistent across studies. To advance HIV prevention intervention research for YMSM, future studies should be theory-based, identify common constructs, utilize standard measures, include process evaluation, and evaluate sustained change over standard periods of time. HIV prevention interventions should incorporate the needs of the diverse, well-educated, web-connected millennial generation and differentiate between adolescent YMSM (13 to 18 years of age) and young adulthood YMSM (19 to 24 years of age). Because Black/African American YMSM represent more than 50% of new HIV infections, future HIV prevention intervention studies should prioritize these young men.

A Comparative Study of Multi-material Data Structures for Computational Physics Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garimella, Rao Veerabhadra; Robey, Robert W.

The data structures used to represent the multi-material state of a computational physics application can have a drastic impact on the performance of the application. We look at efficient data structures for sparse applications where there may be many materials, but only one or few in most computational cells. We develop simple performance models for use in selecting possible data structures and programming patterns. We verify the analytic models of performance through a small test program of the representative cases.

Systems Operation Studies for Automated Guideway Transit Systems : Representative Application Areas for AGT

DOT National Transportation Integrated Search

1980-11-01

The purpose of the Application Area Definition task is to define the travel demands and guideway networks for a set of representative AGT system deployments. These demands and networks, when combined with detailed descriptions of the systems and thei...

The German VR Simulation Realism Scale--psychometric construction for virtual reality applications with virtual humans.

PubMed

Poeschl, Sandra; Doering, Nicola

2013-01-01

Virtual training applications with high levels of immersion or fidelity (for example for social phobia treatment) produce high levels of presence and therefore belong to the most successful Virtual Reality developments. Whereas display and interaction fidelity (as sub-dimensions of immersion) and their influence on presence are well researched, realism of the displayed simulation depends on the specific application and is therefore difficult to measure. We propose to measure simulation realism by using a self-report questionnaire. The German VR Simulation Realism Scale for VR training applications was developed based on a translation of scene realism items from the Witmer-Singer-Presence Questionnaire. Items for realism of virtual humans (for example for social phobia training applications) were supplemented. A sample of N = 151 students rated simulation realism of a Fear of Public Speaking application. Four factors were derived by item- and principle component analysis (Varimax rotation), representing Scene Realism, Audience Behavior, Audience Appearance and Sound Realism. The scale developed can be used as a starting point for future research and measurement of simulation realism for applications including virtual humans.

[Related issues in clinical translational application of adipose-derived stem cells].

PubMed

Liu, Hongwei; Cheng, Biao; Fu, Xiaobing

2012-10-01

To introduce the related issues in the clinical translational application of adipose-derived stem cells (ASCs). The latest papers were extensively reviewed, concerning the issues of ASCs production, management, transportation, use, and safety during clinical application. ASCs, as a new member of adult stem cells family, bring to wide application prospect in the field of regenerative medicine. Over 40 clinical trials using ASCs conducted in 15 countries have been registered on the website (http://www.clinicaltrials.gov) of the National Institutes of Health (NIH), suggesting that ASCs represents a promising approach to future cell-based therapies. In the clinical translational application, the related issues included the quality control standard that management and production should follow, the prevention measures of pathogenic microorganism pollution, the requirements of enzymes and related reagent in separation process, possible effect of donor site, age, and sex in sampling, low temperature storage, product transportation, and safety. ASCs have the advantage of clinical translational application, much attention should be paid to these issues in clinical application to accelerate the clinical translation process.

Bacterial signaling ecology and potential applications during aquatic biofilm construction.

PubMed

Vega, Leticia M; Alvarez, Pedro J; McLean, Robert J C

2014-07-01

In their natural environment, bacteria and other microorganisms typically grow as surface-adherent biofilm communities. Cell signal processes, including quorum signaling, are now recognized as being intimately involved in the development and function of biofilms. In contrast to their planktonic (unattached) counterparts, bacteria within biofilms are notoriously resistant to many traditional antimicrobial agents and so represent a major challenge in industry and medicine. Although biofilms impact many human activities, they actually represent an ancient mode of bacterial growth as shown in the fossil record. Consequently, many aquatic organisms have evolved strategies involving signal manipulation to control or co-exist with biofilms. Here, we review the chemical ecology of biofilms and propose mechanisms whereby signal manipulation can be used to promote or control biofilms.

Optimal assignment of workers to supporting services in a hospital

NASA Astrophysics Data System (ADS)

Sawik, Bartosz; Mikulik, Jerzy

2008-01-01

Supporting services play an important role in health care institutions such as hospitals. This paper presents an application of operations research model for optimal allocation of workers among supporting services in a public hospital. The services include logistics, inventory management, financial management, operations management, medical analysis, etc. The optimality criterion of the problem is to minimize operations costs of supporting services subject to some specific constraints. The constraints represent specific conditions for resource allocation in a hospital. The overall problem is formulated as an integer program in the literature known as the assignment problem, where the decision variables represent the assignment of people to various jobs. The results of some computational experiments modeled on a real data from a selected Polish hospital are reported.

Barotropic instability with divergence - Theory and applications to Venus

NASA Technical Reports Server (NTRS)

Dobrovolskis, Anthony R.; Diner, David J.

1990-01-01

IR images of Venus reveal a curious double-lobed hot spot in the polar region. Elson (1982) has suggested that this dipole represents a barotropic instability associated with a high-latitude jet. Unfortunately, the classical theory of barotropic instability cannot predict temperature variations. This paper generalizes the theory to include horizontal divergence, vertical motions, and temperature variations, and applies it to the stratosphere of Venus. The fastest-growing barotropic instability in the nominal model matches the observed dipole in period and horizontal temperature pattern. The accompanying wind variations are comparable to the speed of the mean jet, indicating strong nonlinear effects. It is concluded that the Venus dipole may represent the self-limited stage of a barotropic instability with divergence.

Linear elastic properties derivation from microstructures representative of transport parameters.

PubMed

Hoang, Minh Tan; Bonnet, Guy; Tuan Luu, Hoang; Perrot, Camille

2014-06-01

It is shown that three-dimensional periodic unit cells (3D PUC) representative of transport parameters involved in the description of long wavelength acoustic wave propagation and dissipation through real foam samples may also be used as a standpoint to estimate their macroscopic linear elastic properties. Application of the model yields quantitative agreement between numerical homogenization results, available literature data, and experiments. Key contributions of this work include recognizing the importance of membranes and properties of the base material for the physics of elasticity. The results of this paper demonstrate that a 3D PUC may be used to understand and predict not only the sound absorbing properties of porous materials but also their transmission loss, which is critical for sound insulation problems.

Evaluation of the impact of lime softening waste disposal in natural environments.

PubMed

Blaisi, Nawaf I; Roessler, Justin; Cheng, Weizhi; Townsend, Timothy; Al-Abed, Souhail R

2015-09-01

Drinking water treatment residues (WTR), generated from the lime softening processes, are commonly reused or disposed of in a number of applications; these include use as a soil amendment or a subsurface fill. Recently questions were posed by the Florida regulatory community on whether lime WTR that contained a small percentage of other treatment additives could appropriately be characterized as lime WTR, in terms of total element content and leachability. A study was done using a broad range of leaching tests, including a framework of tests recently adopted by the United States-Environmental Protection Agency (EPA) and tests that were modified to account for scenario specific conditions, such as the presence of natural organic matter (NOM). The results of these additional leaching tests demonstrated that certain applications, including disposal in a water body with NOM or in placement anaerobic environment, did result in increased leaching of elements such as Fe, and that a site specific assessment should be conducted prior to using WTR in these types of applications. This study illustrates the importance of leaching test selection when attempting to provide an estimation of release in practice. Although leaching tests are just one component in a beneficial use assessment and other factors including aquifer and soil properties play a significant role in the outcome, leaching tests should be tailored to most appropriately represent the scenario or reuse application being evaluated. Copyright © 2015 Elsevier Ltd. All rights reserved.

Counteracting Rotor Imbalance in a Bearingless Motor System with Feedforward Control

NASA Technical Reports Server (NTRS)

Kascak, Peter Eugene; Jansen, Ralph H.; Dever, Timothy; Nagorny, Aleksandr; Loparo, Kenneth

2012-01-01

In standard motor applications, traditional mechanical bearings represent the most economical approach to rotor suspension. However, in certain high performance applications, rotor suspension without bearing contact is either required or highly beneficial. Such applications include very high speed, extreme environment, or limited maintenance access applications. This paper extends upon a novel bearingless motor concept, in which full five-axis levitation and rotation of the rotor is achieved using two motors with opposing conical air-gaps. By leaving the motors' pole-pairs unconnected, different d-axis flux in each pole-pair is created, generating a flux imbalance which creates lateral force. Note this is approach is different than that used in previous bearingless motors, which use separate windings for levitation and rotation. This paper will examine the use of feedforward control to counteract synchronous whirl caused by rotor imbalance. Experimental results will be presented showing the performance of a prototype bearingless system, which was sized for a high speed flywheel energy storage application, with and without feedforward control.

Proceedings of the 8th Precise Time and Time Interval (PTTI) Applications and Planning Meeting

NASA Technical Reports Server (NTRS)

1977-01-01

The Proceedings contain the papers presented at the Eight Annual Precise Time and Tme Interval PTTI Applications and Planning Meeting. The edited record of the discussions following the papers and the panel discussions are also included. This meeting provided a forum for the exchange of information on precise time and frequency technology among members of the scientific community and persons with program applications. The 282 registered attendees came from various U.S. Government agencies, private industry, universities and a number of foreign countries were represented. In this meeting, papers were presented that emphasized: (1) definitions and international regulations of precise time sources and users, (2) the scientific foundations of Hydrogen Maser standards, the current developments in this field and the application experience, and (3) how to measure the stability performance properties of precise standards. As in the previous meetings, update and new papers were presented on system applications with past, present and future requirements identified.

Lockheed laminar-flow control systems development and applications

NASA Technical Reports Server (NTRS)

Lange, Roy H.

1987-01-01

Progress is summarized from 1974 to the present in the practical application of laminar-flow control (LFC) to subsonic transport aircraft. Those efforts included preliminary design system studies of commercial and military transports and experimental investigations leading to the development of the leading-edge flight test article installed on the NASA JetStar flight test aircraft. The benefits of LFC on drag, fuel efficiency, lift-to-drag ratio, and operating costs are compared with those for turbulent flow aircraft. The current activities in the NASA Industry Laminar-Flow Enabling Technologies Development contract include summaries of activities in the Task 1 development of a slotted-surface structural concept using advanced aluminum materials and the Task 2 preliminary conceptual design study of global-range military hybrid laminar flow control (HLFC) to obtain data at high Reynolds numbers and at Mach numbers representative of long-range subsonic transport aircraft operation.

Computational electronics and electromagnetics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shang, C. C.

The Computational Electronics and Electromagnetics thrust area at Lawrence Livermore National Laboratory serves as the focal point for engineering R&D activities for developing computer-based design, analysis, and tools for theory. Key representative applications include design of particle accelerator cells and beamline components; engineering analysis and design of high-power components, photonics, and optoelectronics circuit design; EMI susceptibility analysis; and antenna synthesis. The FY-96 technology-base effort focused code development on (1) accelerator design codes; (2) 3-D massively parallel, object-oriented time-domain EM codes; (3) material models; (4) coupling and application of engineering tools for analysis and design of high-power components; (5) 3-D spectral-domainmore » CEM tools; and (6) enhancement of laser drilling codes. Joint efforts with the Power Conversion Technologies thrust area include development of antenna systems for compact, high-performance radar, in addition to novel, compact Marx generators. 18 refs., 25 figs., 1 tab.« less

Stable Metal–Organic Frameworks with Group 4 Metals: Current Status and Trends

PubMed Central

2018-01-01

Group 4 metal-based metal–organic frameworks (MIV-MOFs), including Ti-, Zr-, and Hf-based MOFs, are one of the most attractive classes of MOF materials owing to their superior chemical stability and structural tunability. Despite being a relatively new field, MIV-MOFs have attracted significant research attention in the past few years, leading to exciting advances in syntheses and applications. In this outlook, we start with a brief overview of the history and current status of MIV-MOFs, emphasizing the challenges encountered in their syntheses. The unique properties of MIV-MOFs are discussed, including their high chemical stability and strong tolerance toward defects. Particular emphasis is placed on defect engineering in Zr-MOFs which offers additional routes to tailor their functions. Photocatalysis of MIV-MOF is introduced as a representative example of their emerging applications. Finally, we conclude with the perspective of new opportunities in synthesis and defect engineering. PMID:29721526

40 CFR 427.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Millboard... by the application of the best available technology economically achievable. The following...

40 CFR 411.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CEMENT MANUFACTURING POINT SOURCE CATEGORY Nonleaching... by the application of the best available technology economically achievable. The following...

40 CFR 427.103 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Vapor Absorption... by the application of the best available technology economically achievable. The following...

40 CFR 427.63 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Roofing... by the application of the best available technology economically achievable. The following...

40 CFR 455.64 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS PESTICIDE CHEMICALS Repackaging of Agricultural Pesticides... effluent reduction attainable by the application of the best available technology economically achievable...

Virtualization of Event Sources in Wireless Sensor Networks for the Internet of Things

PubMed Central

Martínez, Néstor Lucas; Martínez, José-Fernán; Díaz, Vicente Hernández

2014-01-01

Wireless Sensor Networks (WSNs) are generally used to collect information from the environment. The gathered data are delivered mainly to sinks or gateways that become the endpoints where applications can retrieve and process such data. However, applications would also expect from a WSN an event-driven operational model, so that they can be notified whenever occur some specific environmental changes instead of continuously analyzing the data provided periodically. In either operational model, WSNs represent a collection of interconnected objects, as outlined by the Internet of Things. Additionally, in order to fulfill the Internet of Things principles, Wireless Sensor Networks must have a virtual representation that allows indirect access to their resources, a model that should also include the virtualization of event sources in a WSN. Thus, in this paper a model for a virtual representation of event sources in a WSN is proposed. They are modeled as internet resources that are accessible by any internet application, following an Internet of Things approach. The model has been tested in a real implementation where a WSN has been deployed in an open neighborhood environment. Different event sources have been identified in the proposed scenario, and they have been represented following the proposed model. PMID:25470489

Feasibility and Usability of a Mobile Application to Assess Symptoms and Affect in Patients with Atrial Fibrillation: A Pilot Study.

PubMed

Ghanbari, Hamid; Ansari, Sardar; Ghannam, Michael; Lathkar-Pradhan, Sangeeta; Kratz, Anna; Oral, Hakan; Najarian, Kayvan; Clauw, Daniel; Nallamothu, Brahmajee

2017-01-01

Atrial fibrillation (AF) is the most prevalent arrhythmia leading to hospital admissions. The majority of patients with AF report symptoms that are believed to be associated with the arrhythmia. The symptoms related to AF traditionally are collected during a clinic visit that is influenced by biases associated with recalling the experience over a limited period of time. We designed this pilot study to assess the usability and feasibility of a mobile application to assess symptoms in patients with AF. We designed a mobile application (miAfib) to assess symptoms (chest pain, palpitation, shortness of breath, fatigue, dizziness/lightheadedness), positive affect (happy, excited, content) and negative affect (worried, angry, sad) on multiple occasions throughout the day based on iOS platform. We performed a four-week feasibility trial to examine user adherence, acceptance and experiences with the mobile application. We administered questionnaires to assess factors affecting usage and self-reported acceptance of the application based on a five-point Likert scale with zero representing strongly disagree and 5 representing strongly disagree with. We included ten patients with paroxysmal and persistent AF. The mean number of completed assessments each day was 2.81 ± 1.59 with 94.7% of days with at least one assessment. The users found the application easy to use (4.75±0.46), intended to use it in the future (4.37±1.06) and found it easy to integrate into daily routine (4.5±1.07). In this pilot study, we found participants in this four-week trial reliably used the application and were able to use the app to report their daily symptoms and affect regularly. Participants reported that they found the application easy to use and would consider using the application in the future.

Smartphone applications: A contemporary resource for dermatopathology

PubMed Central

Hanna, Matthew G.; Parwani, Anil V.; Pantanowitz, Liron; Punjabi, Vinod; Singh, Rajendra

2015-01-01

Introduction: Smartphone applications in medicine are becoming increasingly prevalent. Given that most pathologists and pathology trainees today use smartphones, an obvious modality for pathology education is through smartphone applications. “MyDermPath” is a novel smartphone application that was developed as an interactive reference tool for dermatology and dermatopathology, available for iOS and Android. Materials and Methods: “MyDermPath” was developed using Apple Xcode and Google Android SDK. Dermatology images (static and virtual slides) were annotated and configured into an algorithmic format. Each image comprised educational data (diagnosis, clinical information, histopathology, special stains, differential diagnosis, clinical management, linked PubMed references). Added functionality included personal note taking, pop quiz, and image upload capabilities. A website was created (http://mydermpath.com) to mirror the app. Results: The application was released in August 2011 and updated in November 2013. More than 1,100 reference diagnoses, with over 2,000 images are available via the application and website. The application has been downloaded approximately 14,000 times. The application is available for use on iOS and Android platforms. Conclusions: Smartphone applications have tremendous potential for advancing pathology education. “MyDermPath” represents an interactive reference tool for dermatology and dermatopathologists. PMID:26284155

Smartphone applications: A contemporary resource for dermatopathology.

PubMed

Hanna, Matthew G; Parwani, Anil V; Pantanowitz, Liron; Punjabi, Vinod; Singh, Rajendra

2015-01-01

Smartphone applications in medicine are becoming increasingly prevalent. Given that most pathologists and pathology trainees today use smartphones, an obvious modality for pathology education is through smartphone applications. "MyDermPath" is a novel smartphone application that was developed as an interactive reference tool for dermatology and dermatopathology, available for iOS and Android. "MyDermPath" was developed using Apple Xcode and Google Android SDK. Dermatology images (static and virtual slides) were annotated and configured into an algorithmic format. Each image comprised educational data (diagnosis, clinical information, histopathology, special stains, differential diagnosis, clinical management, linked PubMed references). Added functionality included personal note taking, pop quiz, and image upload capabilities. A website was created (http://mydermpath.com) to mirror the app. The application was released in August 2011 and updated in November 2013. More than 1,100 reference diagnoses, with over 2,000 images are available via the application and website. The application has been downloaded approximately 14,000 times. The application is available for use on iOS and Android platforms. Smartphone applications have tremendous potential for advancing pathology education. "MyDermPath" represents an interactive reference tool for dermatology and dermatopathologists.

Results of Evaluation of Solar Thermal Propulsion

NASA Technical Reports Server (NTRS)

Woodcock, Gordon; Byers, Dave

2003-01-01

The solar thermal propulsion evaluation reported here relied on prior research for all information on solar thermal propulsion technology and performance. Sources included personal contacts with experts in the field in addition to published reports and papers. Mission performance models were created based on this information in order to estimate performance and mass characteristics of solar thermal propulsion systems. Mission analysis was performed for a set of reference missions to assess the capabilities and benefits of solar thermal propulsion in comparison with alternative in-space propulsion systems such as chemical and electric propulsion. Mission analysis included estimation of delta V requirements as well as payload capabilities for a range of missions. Launch requirements and costs, and integration into launch vehicles, were also considered. The mission set included representative robotic scientific missions, and potential future NASA human missions beyond low Earth orbit. Commercial communications satellite delivery missions were also included, because if STP technology were selected for that application, frequent use is implied and this would help amortize costs for technology advancement and systems development. A C3 Topper mission was defined, calling for a relatively small STP. The application is to augment the launch energy (C3) available from launch vehicles with their built-in upper stages. Payload masses were obtained from references where available. The communications satellite masses represent the range of payload capabilities for the Delta IV Medium and/or Atlas launch vehicle family. Results indicated that STP could improve payload capability over current systems, but that this advantage cannot be realized except in a few cases because of payload fairing volume limitations on current launch vehicles. It was also found that acquiring a more capable (existing) launch vehicle, rather than adding an STP stage, is the most economical in most cases.

Coded aperture imaging with self-supporting uniformly redundant arrays. [Patent application

DOEpatents

Fenimore, E.E.

1980-09-26

A self-supporting uniformly redundant array pattern for coded aperture imaging. The invention utilizes holes which are an integer times smaller in each direction than holes in conventional URA patterns. A balance correlation function is generated where holes are represented by 1's, nonholes are represented by -1's, and supporting area is represented by 0's. The self-supporting array can be used for low energy applications where substrates would greatly reduce throughput.

JSC Design and Procedural Standards, JSC-STD-8080

NASA Technical Reports Server (NTRS)

Punch, Danny T.

2011-01-01

This document provides design and procedural requirements appropriate for inclusion in specifications for any human spaceflight program, project, spacecraft, system, or end item. The term "spacecraft" as used in the standards includes launch vehicles, orbital vehicles, non-terrestrial surface vehicles, and modules. The standards are developed and maintained as directed by Johnson Space Center (JSC) Policy Directive JPD 8080.2, JSC Design and Procedural Standards for Human Space Flight Equipment. The Design and Procedural Standards contained in this manual represent human spacecraft design and operational knowledge applicable to a wide range of spaceflight activities. These standards are imposed on JSC human spaceflight equipment through JPD 8080.2. Designers shall comply with all design standards applicable to their design effort.

Unified constitutive models for high-temperature structural applications

NASA Technical Reports Server (NTRS)

Lindholm, U. S.; Chan, K. S.; Bodner, S. R.; Weber, R. M.; Walker, K. P.

1988-01-01

Unified constitutive models are characterized by the use of a single inelastic strain rate term for treating all aspects of inelastic deformation, including plasticity, creep, and stress relaxation under monotonic or cyclic loading. The structure of this class of constitutive theory pertinent for high temperature structural applications is first outlined and discussed. The effectiveness of the unified approach for representing high temperature deformation of Ni-base alloys is then evaluated by extensive comparison of experimental data and predictions of the Bodner-Partom and the Walker models. The use of the unified approach for hot section structural component analyses is demonstrated by applying the Walker model in finite element analyses of a benchmark notch problem and a turbine blade problem.

Chemical formation of soft metal electrodes for flexible and wearable electronics.

PubMed

Wang, Dongrui; Zhang, Yaokang; Lu, Xi; Ma, Zhijun; Xie, Chuan; Zheng, Zijian

2018-06-18

Flexible and wearable electronics is one major technology after smartphones. It shows remarkable application potential in displays and informatics, robotics, sports, energy harvesting and storage, and medicine. As an indispensable part and the cornerstone of these devices, soft metal electrodes (SMEs) are of great significance. Compared with conventional physical processes such as vacuum thermal deposition and sputtering, chemical approaches for preparing SMEs show significant advantages in terms of scalability, low-cost, and compatibility with the soft materials and substrates used for the devices. This review article provides a detailed overview on how to chemically fabricate SMEs, including the material preparation, fabrication technologies, methods to characterize their key properties, and representative studies on different wearable applications.

Patient blood management, what does this actually mean for neonates and infants?

PubMed

Crighton, G L; New, H V; Liley, H G; Stanworth, S J

2018-04-01

Patient blood management (PBM) refers to an evidence-based package of care that aims to improve patient outcomes by optimal use of transfusion therapy, including managing anaemia, preventing blood loss and improving anaemia tolerance in surgical and other patients who may need transfusion. In adults, PBM programmes are well established, yet the definition and implementation of PBM in neonates and children lags behind. Neonates and infants are frequently transfused, yet they are often under-represented in transfusion trials. Adult PBM programmes may not be directly applicable to these populations. We review the literature in neonatal (and applicable paediatric) transfusion medicine and propose specific neonatal PBM definitions and elements. © 2018 British Blood Transfusion Society.

MBE growth of VCSELs for high volume applications

NASA Astrophysics Data System (ADS)

Jäger, Roland; Riedl, Michael C.

2011-05-01

Mass market applications like laser computer mouse or optical data transmission based on vertical-cavity surface-emitting laser (VCSEL) chips need a high over all yield including epitaxy, processing, dicing, mounting and testing. One yield limitation for VCSEL structures is the emission wavelength variation of the substrate surface area leading to the fraction on laser chips which are below or above the specification limits. For most 850 nm VCSEL products a resonator wavelength variation of ±2 nm is common. This represents an average resonator thickness variation of much less than 1% which is quite challenging to be fulfilled on the entire processed wafer surface area. A high over all yield is demonstrated on MBE grown VCSEL structures.

Bond formations by intermolecular and intramolecular trappings of acylketenes and their applications in natural product synthesis†

PubMed Central

Reber, Keith P.; Tilley, S. David

2011-01-01

The reactive intermediates known as acylketenes exhibit a rich chemistry and have been extensively utilized for many types of inter- and intramolecular bond-forming reactions within the field of organic synthesis. Characteristic reactions of acylketenes include cycloadditions, carbon–carbon bond-forming reactions, and nucleophilic capture with alcohols or amines to give β-keto acid derivatives. In particular, the intramolecular capture of acylketene intermediates with pendant nucleophiles represents a powerful method for forming both medium-sized rings and macrocycles, often in high yield. This tutorial review examines the history, generation, and reactivity of acylketenes with a special focus on their applications in the synthesis of natural products. PMID:19847338

On a useful functional representation of control system structure

NASA Technical Reports Server (NTRS)

Malchow, Harvey L.

1988-01-01

An alternative structure for control systems is proposed. The structure is represented by a three-element block diagram and three functional definitions. It is argued that the three functional elements form a canonical set. The set includes the functions description, estimation and control. General overlay of the structure on parallel state and nested-state control systems is discussed. Breakdown of two real nested-state control systems into the proposed functional format is displayed. Application of the process to the mapping of complex control systems R and D efforts is explained with the Mars Rover Sample and Return mission as an example. A previous application of this basic functional structure to Space Station performance requirements organization is discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitcher, C.E.; Zimmerman, D.C.; Tonn, E.M.

Methods were developed for controlling the dental team's occupational exposure to nitrous oxide. The most applicable and effective use of these methods included the use of properly maintained gas delivery equipment, a double-walled scavenging nosepiece and vented suction machine, and minimizing speech by the patient. These methods were evaluated by measuring concentrations of nitrous oxide present in the air inspired by dental personnel. Before their use, the dentist inhaled 900 ppM nitrous oxide; their application reduced his inhaled concentration to 31 ppM, representing a 97% reduction. These methods were well accepted during 157 procedures completed by a group of eightmore » dentists engaged in private practice (four general practitioners, two pedodontists, and two oral surgeons).« less

40 CFR 406.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: there shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... by the application of the best available technology economically achievable. The following...

40 CFR 426.33 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: There shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... attainable by the application of the best available technology economically achievable. The following...

40 CFR 427.23 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: There shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... attainable by the application of the best available technology economically achievable. The following...

40 CFR 426.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: There shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... by the application of the best available technology economically achievable. The following...

40 CFR 427.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: There shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... attainable by the application of the best available technology economically achievable. The following...

40 CFR 424.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: There shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... reduction attainable by the application of the best available technology economically achievable. The...

40 CFR 426.23 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: There shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... attainable by the application of the best available technology economically achievable. The following...

40 CFR 406.33 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... technology economically achievable: there shall be no discharge of process waste water pollutants to... representing the degree of effluent reduction attainable by the application of the best available technology... by the application of the best available technology economically achievable. The following...

40 CFR 430.34 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... biocides are used must achieve the following effluent limitations representing the degree of effluent... shall be subject to concentration limitations. Concentration limitations are only applicable to non-continuous dischargers. Permittees not using chlorophenolic-containing biocides must certify to the permit...

40 CFR 430.14 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... biocides are used must achieve the following effluent limitations representing the degree of effluent... shall be subject to concentration limitations. Concentration limitations are only applicable to non-continuous dischargers. Permittees not using chlorophenolic-containing biocides must certify to the permit...

40 CFR 430.14 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... chlorophenolic-containing biocides are used must achieve the following effluent limitations representing the.../kkg (lb/1000 lb) but shall be subject to concentration limitations. Concentration limitations are only applicable to non-continuous dischargers. Permittees not using chlorophenolic-containing biocides must...

40 CFR 420.137 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best control technology for... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS IRON AND STEEL MANUFACTURING POINT SOURCE CATEGORY... effluent reduction attainable by the application of the best control technology for conventional pollutants...

40 CFR 427.73 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ASBESTOS MANUFACTURING POINT SOURCE CATEGORY Asbestos Floor... attainable by the application of the best available technology economically achievable. The following...

40 CFR 411.23 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CEMENT MANUFACTURING POINT SOURCE CATEGORY Leaching Subcategory... application of the best available technology economically achievable. The following limitations establish the...

40 CFR 430.104 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... chlorophenolic-containing biocides are used must achieve the following effluent limitations representing the... applicable to non-continuous dischargers. Permittees not using chlorophenolic-containing biocides must certify to the permit-issuing authority that they are not using these biocides: Subpart J [BAT effluent...

40 CFR 430.94 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... chlorophenolic-containing biocides are used must achieve the following effluent limitations representing the... applicable to non-continuous dischargers. Permittees not using chlorophenolic-containing biocides must certify to the permit-issuing authority that they are not using these biocides: Subpart I [Facilities...

40 CFR 463.12 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY... degree of effluent reduction attainable by the application of the best practicable control technology...

40 CFR 463.17 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best conventional pollutant... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Contact... effluent reduction attainable by the application of the best conventional pollutant control technology...

40 CFR 463.32 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY... reduction attainable by the application of the best practicable control technology currently available...

40 CFR 463.13 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best available technology... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY Contact... effluent reduction attainable by the application of the best available technology economically achievable...

40 CFR 463.22 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... representing the degree of effluent reduction attainable by the application of the best practicable control... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS PLASTICS MOLDING AND FORMING POINT SOURCE CATEGORY... reduction attainable by the application of the best practicable control technology currently available...

14 CFR 47.13 - Signatures and instruments made by representatives.

Code of Federal Regulations, 2014 CFR

2014-01-01

... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION General § 47.13 Signatures and instruments made by representatives. (a) Each person signing an Aircraft Registration Application, AC Form 8050-1, or a document submitted... signed in ink, the Aircraft Registration Application must also have the typed or legibly printed name of...

14 CFR 47.13 - Signatures and instruments made by representatives.

Code of Federal Regulations, 2013 CFR

2013-01-01

... TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION General § 47.13 Signatures and instruments made by representatives. (a) Each person signing an Aircraft Registration Application, AC Form 8050-1, or a document submitted... signed in ink, the Aircraft Registration Application must also have the typed or legibly printed name of...

Formal ontologies in biomedical knowledge representation.

PubMed

Schulz, S; Jansen, L

2013-01-01

Medical decision support and other intelligent applications in the life sciences depend on increasing amounts of digital information. Knowledge bases as well as formal ontologies are being used to organize biomedical knowledge and data. However, these two kinds of artefacts are not always clearly distinguished. Whereas the popular RDF(S) standard provides an intuitive triple-based representation, it is semantically weak. Description logics based ontology languages like OWL-DL carry a clear-cut semantics, but they are computationally expensive, and they are often misinterpreted to encode all kinds of statements, including those which are not ontological. We distinguish four kinds of statements needed to comprehensively represent domain knowledge: universal statements, terminological statements, statements about particulars and contingent statements. We argue that the task of formal ontologies is solely to represent universal statements, while the non-ontological kinds of statements can nevertheless be connected with ontological representations. To illustrate these four types of representations, we use a running example from parasitology. We finally formulate recommendations for semantically adequate ontologies that can efficiently be used as a stable framework for more context-dependent biomedical knowledge representation and reasoning applications like clinical decision support systems.

Development of new materials from waste electrical and electronic equipment: Characterization and catalytic application.

PubMed

Souza, J P; Freitas, P E; Almeida, L D; Rosmaninho, M G

2017-07-01

Wastes of electrical and electronic equipment (WEEE) represent an important environmental problem, since its composition includes heavy metals and organic compounds used as flame-retardants. Thermal treatments have been considered efficient processes on removal of these compounds, producing carbonaceous structures, which, together with the ceramic components of the WEEE (i.e. silica and alumina), works as support material for the metals. This mixture, associated with the metals present in WEEE, represents promising systems with potential for catalytic application. In this work, WEEE was thermally modified to generate materials that were extensively characterized. Raman spectrum for WEEE after thermal treatment showed two carbon associated bands. SEM images showed a metal nanoparticles distribution over a polymeric and ceramic support. After characterization, WEEE materials were applied in ethanol steam reforming reaction. The system obtained at higher temperature (800°C) exhibited the best activity, since it leads to high conversions (85%), hydrogen yield (30%) and H 2 /CO ratio (3,6) at 750°C. Copyright © 2017 Elsevier Ltd. All rights reserved.

Accommodation requirements for microgravity science and applications research on space station

NASA Technical Reports Server (NTRS)

Uhran, M. L.; Holland, L. R.; Wear, W. O.

1985-01-01

Scientific research conducted in the microgravity environment of space represents a unique opportunity to explore and exploit the benefits of materials processing in the virtual abscence of gravity induced forces. NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. A study is performed to define from the researchers' perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. The accommodation requirements focus on the microgravity science disciplines including combustion science, electronic materials, metals and alloys, fluids and transport phenomena, glasses and ceramics, and polymer science. User requirements have been identified in eleven research classes, each of which contain an envelope of functional requirements for related experiments having similar characteristics, objectives, and equipment needs. Based on these functional requirements seventeen items of experiment apparatus and twenty items of core supporting equipment have been defined which represent currently identified equipment requirements for a pressurized laboratory module at the initial operating capability of the NASA space station.

Thermal performance demonstration of a prototype internally cooled nose tip/forebody/window assembly

NASA Astrophysics Data System (ADS)

Wojciechowski, Carl J.; Brooks, Lori C.; Teal, Gene; Karu, Zain; Kalin, David A.; Jones, Gregory W.; Romero, Harold

1996-11-01

Internally liquid cooled apertures (windows) installed in a full size forebody have been characterized under high heat flux conditions representative of endoatmospheric flight. Analysis and test data obtained in the laboratory and at arc heater test facilities at Arnold Engineering Development Center and NASA Ames are presented in this paper. Data for several types of laboratory bench tests are presented: transmission interferometry and imaging, coolant pressurization effects on optical quality, and coolant flow rate calibrations for both the window and other internally cooled components. Initially, using heat transfer calibration models identical in shape to the flight test articles, arc heater facility thermal test environments were obtained at several conditions representative of full flight thermal environments. Subsequent runs tested the full-up flight article including nosetip, forebody and aperture for full flight duplication of surface heating rates and exposure ties. Pretest analyses compared will to test measurements. These data demonstrate a very efficient internal liquid cooling design which can be applied to other applications such as cooled mirrors for high heat flux applications.

Progress and prospects in pharmacogenetics of antidepressant drugs.

PubMed

Fabbri, Chiara; Crisafulli, Concetta; Calabrò, Marco; Spina, Edoardo; Serretti, Alessandro

2016-10-01

Depression is responsible for the most part of the personal and socio-economic burden due to psychiatric disorders. Since antidepressant response clusters in families, pharmacogenetics represents a meaningful tool to provide tailored treatments and improve the prognosis of depression. This review aims to summarize and discuss the pharmacogenetics of antidepressant drugs in major depressive disorder, with a focus on the most replicated genes, genome-wide association studies (GWAS), but also on the findings provided by new and promising analysis methods. In particular, multimarker tests such as pathway analysis and polygenic risk scores increase the power of detecting associations compared to the analysis of individual polymorphisms. Since genetic variants are not necessarily associated with a change in protein level, gene expression studies may provide complementary information to genetic studies. Finally, the pharmacogenetic tests that have been investigated for clinical application are discussed. Despite the lack of widespread clinical applications, preliminary results suggest that pharmacogenetics may be useful to guide antidepressant treatment. The US Food and Drug Administration included pharmacogenetic indications in the labeling of several antidepressants. This represented an important official recognition of the clinical relevance of genetic polymorphisms in antidepressant treatment.

Lantibiotics produced by Actinobacteria and their potential applications (a review).

PubMed

Gomes, Karen Machado; Duarte, Rafael Silva; de Freire Bastos, Maria do Carmo

2017-02-01

The phylum Actinobacteria, which comprises a great variety of Gram-positive bacteria with a high G+C content in their genomes, is known for its large production of bioactive compounds, including those with antimicrobial activity. Among the antimicrobials, bacteriocins, ribosomally synthesized peptides, represent an important arsenal of potential new drugs to face the increasing prevalence of resistance to antibiotics among microbial pathogens. The actinobacterial bacteriocins form a heterogeneous group of substances that is difficult to adapt to most proposed classification schemes. However, recent updates have accommodated efficiently the diversity of bacteriocins produced by this phylum. Among the bacteriocins, the lantibiotics represent a source of new antimicrobials to control infections caused mainly by Gram-positive bacteria and with a low propensity for resistance development. Moreover, some of these compounds have additional biological properties, exhibiting activity against viruses and tumour cells and having also potential to be used in blood pressure or inflammation control and in pain relief. Thus, lantibiotics already described in Actinobacteria exhibit potential practical applications in medical settings, food industry and agriculture, with examples at different stages of pre-clinical and clinical trials.

Glycoengineering of CHO Cells to Improve Product Quality.

PubMed

Wang, Qiong; Yin, Bojiao; Chung, Cheng-Yu; Betenbaugh, Michael J

2017-01-01

Chinese hamster ovary (CHO) cells represent the predominant platform in biopharmaceutical industry for the production of recombinant biotherapeutic proteins, especially glycoproteins. These glycoproteins include oligosaccharide or glycan attachments that represent one of the principal components dictating product quality. Especially important are the N-glycan attachments present on many recombinant glycoproteins of commercial interest. Furthermore, altering the glycan composition can be used to modulate the production quality of a recombinant biotherapeutic from CHO and other mammalian hosts. This review first describes the glycosylation network in mammalian cells and compares the glycosylation patterns between CHO and human cells. Next genetic strategies used in CHO cells to modulate the sialylation patterns through overexpression of sialyltransfereases and other glycosyltransferases are summarized. In addition, other approaches to alter sialylation including manipulation of sialic acid biosynthetic pathways and inhibition of sialidases are described. Finally, this review also covers other strategies such as the glycosylation site insertion and manipulation of glycan heterogeneity to produce desired glycoforms for diverse biotechnology applications.

Regional Climate Simulation and Data Assimilation with Variable-Resolution GCMs

NASA Technical Reports Server (NTRS)

Fox-Rabinovitz, Michael S.

2002-01-01

Variable resolution GCMs using a global stretched grid (SG) with enhanced regional resolution over one or multiple areas of interest represents a viable new approach to regional climateklimate change and data assimilation studies and applications. The multiple areas of interest, at least one within each global quadrant, include the major global mountains and major global monsoonal circulations over North America, South America, India-China, and Australia. They also can include the polar domains, and the European and African regions. The SG-approach provides an efficient regional downscaling to mesoscales, and it is an ideal tool for representing consistent interactions of globaYlarge- and regionallmeso- scales while preserving the high quality of global circulation. Basically, the SG-GCM simulations are no different from those of the traditional uniform-grid GCM simulations besides using a variable-resolution grid. Several existing SG-GCMs developed by major centers and groups are briefly described. The major discussion is based on the GEOS (Goddard Earth Observing System) SG-GCM regional climate simulations.

An interactive GIS based tool on Chinese history and its topography

NASA Astrophysics Data System (ADS)

Konda, Ashish Reddy

The aim of the thesis is to demonstrate how China was attacked by the foreign powers, the rise and fall of the empires, the border conflicts with India, Russia, Vietnam and territorial disputes in South China Sea. This thesis is focused on creating a GIS tool showcasing the modern Chinese history, which includes the major wars fought during that period. This tool is developed using the features of Google Maps that shows the location of the wars. The topography of China is also represented on the interactive Google Map by creating layers for rivers, mountain ranges and deserts. The provinces with highest population are also represented on the Google Map with circles. The application also shows the historical events in chronological order using a timeline feature. This has been implemented using JQuery, JavaScript, HTML5 and CSS. Chinese culture and biographies of important leaders are also included in this thesis, which is embedded with pictures and videos.

oPOSSUM: integrated tools for analysis of regulatory motif over-representation

PubMed Central

Ho Sui, Shannan J.; Fulton, Debra L.; Arenillas, David J.; Kwon, Andrew T.; Wasserman, Wyeth W.

2007-01-01

The identification of over-represented transcription factor binding sites from sets of co-expressed genes provides insights into the mechanisms of regulation for diverse biological contexts. oPOSSUM, an internet-based system for such studies of regulation, has been improved and expanded in this new release. New features include a worm-specific version for investigating binding sites conserved between Caenorhabditis elegans and C. briggsae, as well as a yeast-specific version for the analysis of co-expressed sets of Saccharomyces cerevisiae genes. The human and mouse applications feature improvements in ortholog mapping, sequence alignments and the delineation of multiple alternative promoters. oPOSSUM2, introduced for the analysis of over-represented combinations of motifs in human and mouse genes, has been integrated with the original oPOSSUM system. Analysis using user-defined background gene sets is now supported. The transcription factor binding site models have been updated to include new profiles from the JASPAR database. oPOSSUM is available at http://www.cisreg.ca/oPOSSUM/ PMID:17576675

Singlet Oxygen Generation by Cyclometalated Complexes and Applications†

PubMed Central

Ashen-Garry, David; Selke, Matthias

2014-01-01

While cyclometalated complexes have been extensively studied for optoelectronic applications, these compounds also represent a relatively new class of photosensitizers for the production of singlet oxygen. Thus far, singlet oxygen generation from cyclometalated Ir and Pt complexes has been studied in detail. In this review, photophysical data for singlet oxygen generation from these complexes is presented, and the mechanism of 1O2 generation is discussed, including evidence for singlet oxygen generation via an electron transfer mechanism for some of cyclometalated Ir complexes. The period from the first report of singlet oxygen generation by a cyclometalated Ir complex in 2002 through August 2013 is covered in this review. This new class of singlet oxygen photosensitizers may prove to be rather versatile due to the ease of substitution of ancillary ligands without loss of activity. Several cyclometalated complexes have been tethered to zeolites, polystyrene, or quantum dots. Applications for photooxygenation of organic molecules, including “traditional” singlet oxygen reactions (ene reaction, [4+2] and [2+2] cycloadditions) as well as oxidative coupling of amines are presented. Potential biomedical applications are also reviewed. PMID:24344628

Thermostable microbial xylanases for pulp and paper industries: trends, applications and further perspectives.

PubMed

Kumar, Vishal; Marín-Navarro, Julia; Shukla, Pratyoosh

2016-02-01

Xylanases are enzymes with biotechnological relevance in a number of fields, including food, feed, biofuel, and textile industries. Their most significant application is in the paper and pulp industry, where they are used as a biobleaching agent, showing clear economic and environmental advantages over chemical alternatives. Since this process requires high temperatures and alkali media, the identification of thermostable and alkali stable xylanases represents a major biotechnological goal in this field. Moreover, thermostability is a desirable property for many other applications of xylanases. The review makes an overview of xylanase producing microorganisms and their current implementation in paper biobleaching. Future perspectives are analyzed focusing in the efforts carried out to generate thermostable enzymes by means of modern biotechnological tools, including metagenomic analysis, enzyme molecular engineering and nanotechnology. Furthermore, structural and mutagenesis studies have revealed critical sites for stability of xylanases from glycoside hydrolase families GH10 and GH11, which constitute the main classes of these enzymes. The overall conclusions of these works are summarized here and provide relevant information about putative weak spots within xylanase structures to be targeted in future protein engineering approaches.

Use of geographic information systems for applications on gas pipeline rights-of-way. Final report, December 1989--December 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, P.J.

1991-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way for this project (ROWs) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1)more » determination of environmentally sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWs; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Use of geographic information systems for applications on gas pipeline rights-of-way

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, P.J.

1991-12-01

Geographic information system (GIS) applications for the siting and monitoring of gas pipeline rights-of-way for this project (ROWs) were developed for areas near Rio Vista, California. The data layers developed for this project represent geographic features, such as landcover, elevation, aspect, slope, soils, hydrography, transportation, endangered species, wetlands, and public line surveys. A GIS was used to develop and store spatial data from several sources; to manipulate spatial data to evaluate environmental and engineering issues associated with the siting, permitting, construction, maintenance, and monitoring of gas pipeline ROWS; and to graphically display analysis results. Examples of these applications include (1)more » determination of environmentally sensitive areas, such as endangered species habitat, wetlands, and areas of highly erosive soils; (2) evaluation of engineering constraints, including shallow depth to bedrock, major hydrographic features, and shallow water table; (3) classification of satellite imagery for landuse/landcover that will affect ROWs; and (4) identification of alternative ROW corridors that avoid environmentally sensitive areas or areas with severe engineering constraints.« less

Nanotechnology research for aerospace applications

NASA Astrophysics Data System (ADS)

Agee, Forrest J.; Lozano, Karen; Gutierrez, Jose M.; Chipara, Mircea; Thapa, Ram; Chow, Alice

2009-04-01

Nanotechnology is impacting the future of the military and aerospace. The increasing demands for high performance and property-specific applications are forcing the scientific world to take novel approaches in developing programs and accelerating output. CONTACT or Consortium for Nanomaterials for Aerospace Commerce and Technology is a cooperative nanotechnology research program in Texas building on an infrastructure that promotes collaboration between universities and transitioning to industry. The participants of the program include the US Air Force Research Laboratory (AFRL), five campuses of the University of Texas (Brownsville, Pan American, Arlington, Austin, and Dallas), the University of Houston, and Rice University. Through the various partnerships between the intellectual centers and the interactions with AFRL and CONTACT's industrial associates, the program represents a model that addresses the needs of the changing and competitive technological world. Into the second year, CONTACT has expanded to twelve projects that cover four areas of research: Adaptive Coatings and Surface Engineering, Nano Energetics, Electromagnetic Sensors, and Power Generation and Storage. This paper provides an overview of the CONTACT program and its projects including the research and development of new electrorheological fluids with nanoladen suspensions and composites and the potential applications.

EDITORIAL: Cluster issue on microplasmas

NASA Astrophysics Data System (ADS)

Chao, Chih C.; Liao, Jiunn-Der; Chang, Juu-En

2008-10-01

Ever since the first Workshop on Microplasmas, held in Japan in 2003, plasma scientists and engineers worldwide have been meeting approximately every 18 months to exchange and discuss the results of scientific research and technical applications of this unique type of plasma. Microplasmas are generally described as stable plasmas confined to spatial dimensions below about 1 mm that can be operated at pressures up to and exceeding atmospheric pressure. By their nature, this presents a wide range of opportunities and many advantages in practical applications, just a few examples being low energy consumption, small size, flexibility of use and ease of assembly into a user-friendly package. Nevertheless, there still remain several unanswered basic science questions and a largely untapped potential for environmental, biomedical and industrial applications. The fourth International Workshop on Microplasmas, held during 28-31 October 2007 in Tainan, Taiwan, continued the trend of previous Workshops with an orientation towards industrial and environmental applications. Many high-quality papers on microplasmas and microdischarges were presented and selected full papers were submitted to Journal of Physics D: Applied Physics for assessment by the editors and reviewers in accordance with the usual standards of quality and novelty. This Cluster Issue contains twelve accepted papers, covering four categories: fundamentals and basics, and environmental, biomedical and industrial applications. Fundamentals and basics includes coverage of the physics and microstructure of electrode discharge (Yu A Lebedev et al), the characteristics of low current discharge (Z Lj Petrović et al), plasma ignition (R Gesche et al), novel optical diagnostics (Schulz-von der Gathen et al), plasma generation and micronozzle flow (T Takahashi et al) and the relation between RF-power and atomic oxygen density distribution (N Knake et al). Environmental applications are represented by vapour-phase discharges in liquid capillaries (P Bruggeman et al) and biomedical applications by antibacterial treatment (K D Weltmann et al). Industrial applications include on-chip microplasma reactors (A Agiral et al), miniaturized atmospheric pressure plasma jets (J Schäfer et al and A V Pipa et al) and microplasma stamps (N Lucas et al). All of these represent important findings and advances in microplasma research and applications. We would like to thank the Publisher of the journal, Sarah Quin, and the editorial staff for their support and management of the publication. It is sincerely hoped that the contents of this Cluster Issue will promote understanding of microplasmas and microdischarges, and inspire further research towards industrial applications.

Internal combustion engine for natural gas compressor operation

DOEpatents

Hagen, Christopher; Babbitt, Guy

2016-12-27

This application concerns systems and methods for compressing natural gas with an internal combustion engine. In a representative embodiment, a method is featured which includes placing a first cylinder of an internal combustion engine in a compressor mode, and compressing a gas within the first cylinder, using the cylinder as a reciprocating compressor. In some embodiments a compression check valve system is used to regulate pressure and flow within cylinders of the engine during a compression process.

Major Events Coordinated Security Solutions: The Application of the Project Management Body of Knowledge for Managing a Science and Technology Project

DTIC Science & Technology

2011-02-01

subject matter experts, to analysis of laboratory samples during V2010. Significance: The MECSS project produced more than 195 scientific reports...represents the sum of knowledge related to project management and includes best practises and techniques generally accepted by the project...2011-03 2.2.1 Science Town Science Town is the moniker for a multi-agency, mobile laboratory capability that brings together world

Conversational Agents in E-Learning

NASA Astrophysics Data System (ADS)

Kerry, Alice; Ellis, Richard; Bull, Susan

This paper discusses the use of natural language or 'conversational' agents in e-learning environments. We describe and contrast the various applications of conversational agent technology represented in the e-learning literature, including tutors, learning companions, language practice and systems to encourage reflection. We offer two more detailed examples of conversational agents, one which provides learning support, and the other support for self-assessment. Issues and challenges for developers of conversational agent systems for e-learning are identified and discussed.

WFIRST Observatory Performance

NASA Technical Reports Server (NTRS)

Kruk, Jeffrey W.

2012-01-01

The WFIRST observatory will be a powerful and flexible wide-field near-infrared facility. The planned surveys will provide data applicable to an enormous variety of astrophysical science. This presentation will provide a description of the observatory and its performance characteristics. This will include a discussion of the point spread function, signal-to-noise budgets for representative observing scenarios and the corresponding limiting sensitivity. Emphasis will be given to providing prospective Guest Observers with information needed to begin thinking about new observing programs.

Trees, B-series and G-symplectic methods

NASA Astrophysics Data System (ADS)

Butcher, J. C.

2017-07-01

The order conditions for Runge-Kutta methods are intimately connected with the graphs known as rooted trees. The conditions can be expressed in terms of Taylor expansions written as weighted sums of elementary differentials, that is as B-series. Polish notation provides a unifying structure for representing many of the quantities appearing in this theory. Applications include the analysis of general linear methods with special reference to G-symplectic methods. A new order 6 method has recently been constructed.

Immunization. Safety and Use of Polio Vaccines. Briefing Report to the Chairman, Subcommittee on Natural Resources, Agriculture Research and Environment, Committee on Science, Space, and Technology, House of Representatives.

ERIC Educational Resources Information Center

General Accounting Office, Washington, DC.

This report presents information on the status of the safety and use of polio vaccines in the United States. Topics discussed include: (1) the role of the Food and Drug Administration (FDA) in processing an inactivated polio vaccine license application; (2) the steps the federal government has taken to improve the safety of the vaccine; (3) the…

Educational Applications for Blind and Partially Sighted Pupils Based on Speech Technologies for Serbian.

PubMed

Lučić, Branko; Ostrogonac, Stevan; Vujnović Sedlar, Nataša; Sečujski, Milan

2015-01-01

The inclusion of persons with disabilities has always represented an important issue. Advancements within the field of computer science have enabled the development of different types of aids, which have significantly improved the quality of life of the disabled. However, for some disabilities, such as visual impairment, the purpose of these aids is to establish an alternative communication channel and thus overcome the user's disability. Speech technologies play the crucial role in this process. This paper presents the ongoing efforts to create a set of educational applications based on speech technologies for Serbian for the early stages of education of blind and partially sighted children. Two educational applications dealing with memory exercises and comprehension of geometrical shapes are presented, along with the initial tests results obtained from research including visually impaired pupils.

Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications

PubMed Central

Ruocco, Nadia; Costantini, Susan; Palumbo, Flora; Costantini, Maria

2017-01-01

Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, including cancers. In the last several years, enzyme inhibitors, being good candidates as drugs in the pathogenic processes, have received an increasing amount of attention for their potential application in pharmacology. The marine environment is considered a challenging source of enzyme inhibitors for pharmacological applications. In this review, we report on secondary metabolites with enzyme inhibitory activity, focusing our attention on marine sponges and bacteria as promising sources. In the case of sponges, we only reported the kinase inhibitors, because this class was the most representative isolated so far from these marine organisms. PMID:28604647

Earth benefits from NASA research and technology. Life sciences applications

NASA Technical Reports Server (NTRS)

1991-01-01

This document provides a representative sampling of examples of Earth benefits in life-sciences-related applications, primarily in the area of medicine and health care, but also in agricultural productivity, environmental monitoring and safety, and the environment. This brochure is not intended as an exhaustive listing, but as an overview to acquaint the reader with the breadth of areas in which the space life sciences have, in one way or another, contributed a unique perspective to the solution of problems on Earth. Most of the examples cited were derived directly from space life sciences research and technology. Some examples resulted from other space technologies, but have found important life sciences applications on Earth. And, finally, we have included several areas in which Earth benefits are anticipated from biomedical and biological research conducted in support of future human exploration missions.

A case study on the application of isotope ratio mass spectrometry (IRMS) in determining the provenance of a rock used in an alleged nickel switching incident.

PubMed

Roelofse, F; Horstmann, U E

2008-01-15

The application of isotope ratio mass spectrometry (IRMS) in forensic science to establish the provenance of a range of questioned substances including soils, drugs, explosives, currency, ivory and rhino horn has been widely documented. The present study wishes to highlight the applicability of IRMS and specifically stable carbon IRMS in determining the provenance of a carbonate rock that was switched for nickel metal exported from South Africa to Israel. The technique employed effectively argued against a South African origin for the rock whilst simultaneously supporting an Israeli origin, enabling investigators to focus their attention accordingly. The study represents the first documented instance known to the authors where IRMS has been employed in the forensic geo-location of a rock.

Educational Applications for Blind and Partially Sighted Pupils Based on Speech Technologies for Serbian

PubMed Central

Lučić, Branko; Ostrogonac, Stevan; Vujnović Sedlar, Nataša; Sečujski, Milan

2015-01-01

The inclusion of persons with disabilities has always represented an important issue. Advancements within the field of computer science have enabled the development of different types of aids, which have significantly improved the quality of life of the disabled. However, for some disabilities, such as visual impairment, the purpose of these aids is to establish an alternative communication channel and thus overcome the user's disability. Speech technologies play the crucial role in this process. This paper presents the ongoing efforts to create a set of educational applications based on speech technologies for Serbian for the early stages of education of blind and partially sighted children. Two educational applications dealing with memory exercises and comprehension of geometrical shapes are presented, along with the initial tests results obtained from research including visually impaired pupils. PMID:26171422

State Health Mapper: An Interactive, Web-Based Tool for Physician Workforce Planning, Recruitment, and Health Services Research.

PubMed

Krause, Denise D

2015-11-01

Health rankings in Mississippi are abysmal. Mississippi also has fewer physicians to serve its population compared with all other states. Many residents of this predominately rural state do not have access to healthcare providers. To better understand the demographics and distribution of the current health workforce in Mississippi, the main objective of the study was to design a Web-based, spatial, interactive application to visualize and explore the physician workforce. A Web application was designed to assist in health workforce planning. Secondary datasets of licensure and population information were obtained, and live feeds from licensure systems are being established. Several technologies were used to develop an intuitive, user-friendly application. Custom programming was completed in JavaScript so the application could run on most platforms, including mobile devices. The application allows users to identify and query geographic locations of individual or aggregated physicians based on attributes included in the licensure data, to perform drive time or buffer analyses, and to explore sociodemographic population data by geographic area of choice. This Web-based application with analytical tools visually represents the physician workforce licensed in Mississippi and its attributes, and provides access to much-needed information for statewide health workforce planning and research. The success of the application is not only based on the practicality of the tool but also on its ease of use. Feedback has been positive and has come from a wide variety of organizations across the state.

Bridging the Gap from Networking Technologies to Applications: Workshop Report

NASA Technical Reports Server (NTRS)

Johnson, Marjory J.; desJardins, Richard

2000-01-01

The objective of the Next Generation Internet (NGI) Federal program is threefold, encompassing development of networking technologies, high-performance network testbeds, and revolutionary applications. There have been notable advances in emerging network technologies and several nationwide testbeds have been established, but the integration of emerging technologies into applications is lagging. To help bridge this gap between developers of NGI networking technologies and developers of NGI applications, the NASA Research and Education Network (NREN) project hosted a two-day workshop at NASA Ames Research Center in August 1999. This paper presents a summary of the results of this workshop and also describes some of the challenges NREN is facing while incorporating new technologies into HPCC and other NASA applications. The workshop focused on three technologies - Quality of Service (QoS), advanced multicast, and security-and five major NGI application areas - telemedicine, digital earth, digital video, distributed data-intensive applications, and computational infrastructure applications. Network technology experts, application developers, and NGI testbed representatives came together at the workshop to promote cross-fertilization between the groups. Presentations on the first day, including an overview of the three technologies, application case studies and testbed status reports, laid the foundation for discussions on the second day. The objective of these latter discussions, held within smaller breakout groups, was to establish a coherent picture of the current status of the various pieces of each of the three technologies, to create a roadmap outlining future technology development, and to offer technological guidance to application developers. In this paper we first present a brief overview of the NGI applications that were represented at the workshop, focusing on the identification of technological advances that have successfully been incorporated in each application and technological challenges that remain. Next we present the technology roadmaps that were created at the workshop, summarizing the status of various mechanisms that are currently under development and forecasting when various advances are likely to occur within the next one-to-three-year time span. Then we identify issues that were raised at the workshop that might hinder technology development or that might impede integration into NGI applications. We also report some specific guidelines that were offered at the workshop to enable application developers to integrate and effectively use emerging NGI technology building blocks. Finally, we describe NREN activities to incorporate emerging technologies into NASA applications. These activities include support for other NASA High-Performance Computing and Communications Program areas such as IPG (Information Power Grid), support for NASA science enterprises such as Earth science and Mars program prototyping activities, support for satellite/terrestrial networking applications such as the TransAtlantic and TransPacific demonstrations and the Interplanetary Internet, support for NASA telemedicine applications such as the Virtual Collaborative Clinic, and participation in NGI advanced technology testbed initiatives such as the QBone and the NTON/Supernet. For each activity we highlight the primary technological challenge that is associated with it.

Cryopreservation of Human Mesenchymal Stem Cells for Clinical Applications: Current Methods and Challenges.

PubMed

Yong, Kar Wey; Wan Safwani, Wan Kamarul Zaman; Xu, Feng; Wan Abas, Wan Abu Bakar; Choi, Jane Ru; Pingguan-Murphy, Belinda

2015-08-01

Mesenchymal stem cells (MSCs) hold many advantages over embryonic stem cells (ESCs) and other somatic cells in clinical applications. MSCs are multipotent cells with strong immunosuppressive properties. They can be harvested from various locations in the human body (e.g., bone marrow and adipose tissues). Cryopreservation represents an efficient method for the preservation and pooling of MSCs, to obtain the cell counts required for clinical applications, such as cell-based therapies and regenerative medicine. Upon cryopreservation, it is important to preserve MSCs functional properties including immunomodulatory properties and multilineage differentiation ability. Further, a biosafety evaluation of cryopreserved MSCs is essential prior to their clinical applications. However, the existing cryopreservation methods for MSCs are associated with notable limitations, leading to a need for new or improved methods to be established for a more efficient application of cryopreserved MSCs in stem cell-based therapies. We review the important parameters for cryopreservation of MSCs and the existing cryopreservation methods for MSCs. Further, we also discuss the challenges to be addressed in order to preserve MSCs effectively for clinical applications.

Structural equation modeling for observational studies

USGS Publications Warehouse

Grace, J.B.

2008-01-01

Structural equation modeling (SEM) represents a framework for developing and evaluating complex hypotheses about systems. This method of data analysis differs from conventional univariate and multivariate approaches familiar to most biologists in several ways. First, SEMs are multiequational and capable of representing a wide array of complex hypotheses about how system components interrelate. Second, models are typically developed based on theoretical knowledge and designed to represent competing hypotheses about the processes responsible for data structure. Third, SEM is conceptually based on the analysis of covariance relations. Most commonly, solutions are obtained using maximum-likelihood solution procedures, although a variety of solution procedures are used, including Bayesian estimation. Numerous extensions give SEM a very high degree of flexibility in dealing with nonnormal data, categorical responses, latent variables, hierarchical structure, multigroup comparisons, nonlinearities, and other complicating factors. Structural equation modeling allows researchers to address a variety of questions about systems, such as how different processes work in concert, how the influences of perturbations cascade through systems, and about the relative importance of different influences. I present 2 example applications of SEM, one involving interactions among lynx (Lynx pardinus), mongooses (Herpestes ichneumon), and rabbits (Oryctolagus cuniculus), and the second involving anuran species richness. Many wildlife ecologists may find SEM useful for understanding how populations function within their environments. Along with the capability of the methodology comes a need for care in the proper application of SEM.

Medical education for "Dreamers": Barriers and opportunities for undocumented immigrants.

PubMed

Kuczewski, Mark G; Brubaker, Linda

2014-12-01

Medical schools should amend their admissions policies to welcome applications from qualified undocumented immigrants, often called "Dreamers." The recent creation of the Deferred Action for Childhood Arrivals (DACA) program of the U.S. Citizenship and Immigration Service removes the key obstacles to securing a license and residency eligibility for such medical school graduates. As a result, to deny application to Dreamers of DACA status represents a kind of unjustified discrimination and violates the basic ethical principle of the equality of human beings. In addition, the medical profession's duty of beneficence to patients compels medical schools to develop the talents of any and all qualified applicants so as to produce the most competent, diverse physician workforce that best represents contemporary U.S. society. Furthermore, social justice calls for medical schools to produce physicians inclined to serve populations that have traditionally been underserved, including some minority and immigrant populations. An examination of the characteristics of those granted DACA status suggests that they are a potential source of future physicians likely to be helpful in addressing these needs. The authors of this Perspective discuss the remaining challenges facing Dreamers who want to attend medical school in the United States and possible means of overcoming these hurdles. The authors' views are based on principles of social justice, their recognition of the duty to treat Dreamer applicants fairly and justly, and their belief that physicians have an obligation primarily to the patients they serve that entails developing the best health care workforce possible.

Computational physics and applied mathematics capability review June 8-10, 2010 (Advance materials to committee members)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Stephen R

2010-01-01

Los Alamos National Laboratory will review its Computational Physics and Applied Mathematics (CPAM) capabilities in 2010. The goals of capability reviews are to assess the quality of science, technology, and engineering (STE) performed by the capability, evaluate the integration of this capability across the Laboratory and within the scientific community, examine the relevance of this capability to the Laboratory's programs, and provide advice on the current and future directions of this capability. This is the first such review for CPAM, which has a long and unique history at the laboratory, starting from the inception of the Laboratory in 1943. Themore » CPAM capability covers an extremely broad technical area at Los Alamos, encompassing a wide array of disciplines, research topics, and organizations. A vast array of technical disciplines and activities are included in this capability, from general numerical modeling, to coupled mUlti-physics simulations, to detailed domain science activities in mathematics, methods, and algorithms. The CPAM capability involves over 12 different technical divisions and a majority of our programmatic and scientific activities. To make this large scope tractable, the CPAM capability is broken into the following six technical 'themes.' These themes represent technical slices through the CP AM capability and collect critical core competencies of the Laboratory, each of which contributes to the capability (and each of which is divided into multiple additional elements in the detailed descriptions of the themes in subsequent sections): (1) Computational Fluid Dynamics - This theme speaks to the vast array of scientific capabilities for the simulation of fluids under shocks, low-speed flow, and turbulent conditions - which are key, historical, and fundamental strengths of the laboratory; (2) Partial Differential Equations - The technical scope of this theme is the applied mathematics and numerical solution of partial differential equations (broadly defined) in a variety of settings, including particle transport, solvers, and plasma physics; (3) Monte Carlo - Monte Carlo was invented at Los Alamos, and this theme discusses these vitally important methods and their application in everything from particle transport, to condensed matter theory, to biology; (4) Molecular Dynamics - This theme describes the widespread use of molecular dynamics for a variety of important applications, including nuclear energy, materials science, and biological modeling; (5) Discrete Event Simulation - The technical scope of this theme represents a class of complex system evolutions governed by the action of discrete events. Examples include network, communication, vehicle traffic, and epidemiology modeling; and (6) Integrated Codes - This theme discusses integrated applications (comprised of all of the supporting science represented in Themes 1-5) that are of strategic importance to the Laboratory and the nation. The laboratory has in approximately 10 million source lines of code in over 100 different such strategically important applications. Of these themes, four of them will be reviewed during the 2010 review cycle: Themes 1, 2, 3, and 6. Because these capability reviews occur every three years, Themes 4 and 5 will be reviewed in 2013, along with Theme 6 (which will be reviewed during each review, owing to this theme's role as an integrator of the supporting science represented by the other 5 themes). Yearly written status reports will be provided to the Capability Review Committee Chair during off-cycle years.« less

Computational physics and applied mathematics capability review June 8-10, 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Stephen R

2010-01-01

Los Alamos National Laboratory will review its Computational Physics and Applied Mathematics (CPAM) capabilities in 2010. The goals of capability reviews are to assess the quality of science, technology, and engineering (STE) performed by the capability, evaluate the integration of this capability across the Laboratory and within the scientific community, examine the relevance of this capability to the Laboratory's programs, and provide advice on the current and future directions of this capability. This is the first such review for CPAM, which has a long and unique history at the Laboratory, starting from the inception of the Laboratory in 1943. Themore » CPAM capability covers an extremely broad technical area at Los Alamos, encompassing a wide array of disciplines, research topics, and organizations. A vast array of technical disciplines and activities are included in this capability, from general numerical modeling, to coupled multi-physics simulations, to detailed domain science activities in mathematics, methods, and algorithms. The CPAM capability involves over 12 different technical divisions and a majority of our programmatic and scientific activities. To make this large scope tractable, the CPAM capability is broken into the following six technical 'themes.' These themes represent technical slices through the CPAM capability and collect critical core competencies of the Laboratory, each of which contributes to the capability (and each of which is divided into multiple additional elements in the detailed descriptions of the themes in subsequent sections), as follows. Theme 1: Computational Fluid Dynamics - This theme speaks to the vast array of scientific capabilities for the simulation of fluids under shocks, low-speed flow, and turbulent conditions - which are key, historical, and fundamental strengths of the Laboratory. Theme 2: Partial Differential Equations - The technical scope of this theme is the applied mathematics and numerical solution of partial differential equations (broadly defined) in a variety of settings, including particle transport, solvers, and plasma physics. Theme 3: Monte Carlo - Monte Carlo was invented at Los Alamos. This theme discusses these vitally important methods and their application in everything from particle transport, to condensed matter theory, to biology. Theme 4: Molecular Dynamics - This theme describes the widespread use of molecular dynamics for a variety of important applications, including nuclear energy, materials science, and biological modeling. Theme 5: Discrete Event Simulation - The technical scope of this theme represents a class of complex system evolutions governed by the action of discrete events. Examples include network, communication, vehicle traffic, and epidemiology modeling. Theme 6: Integrated Codes - This theme discusses integrated applications (comprised of all of the supporting science represented in Themes 1-5) that are of strategic importance to the Laboratory and the nation. The Laboratory has in approximately 10 million source lines of code in over 100 different such strategically important applications. Of these themes, four of them will be reviewed during the 2010 review cycle: Themes 1,2, 3, and 6. Because these reviews occur every three years, Themes 4 and 5 will be reviewed in 2013, along with Theme 6 (which will be reviewed during each review, owing to this theme's role as an integrator of the supporting science represented by the other five themes). Yearly written status reports will be provided to the CPAM Committee Chair during off-cycle years.« less

40 CFR 430.72 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... through the application of the thermo-mechanical process] Pollutant or pollutant property Kg/kkg (or... where pulp and paper at groundwood chemi-mechanical mills are produced] Pollutant or pollutant property... Mechanical Pulp Subcategory § 430.72 Effluent limitations representing the degree of effluent reduction...

40 CFR 440.142 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ORE MINING AND DRESSING POINT SOURCE CATEGORY Gold Placer Mine... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best practicable control technology...

40 CFR 440.105 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best conventional pollutant control... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ORE MINING AND DRESSING POINT SOURCE CATEGORY Copper...

76 FR 36625 - Application and Termination Notice for Municipal Securities Dealer Principal or Representative

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision Application and Termination Notice for Municipal Securities Dealer Principal or Representative AGENCY: Office of Thrift Supervision (OTS), Treasury... Thrift Supervision, 1700 G Street, NW., Washington, DC 20552, by fax to (202) 906-6518, or by e-mail to...

40 CFR 429.153 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of the best available technology economically achievable (BAT). [Reserved] 429.153 Section 429.153 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES...

40 CFR 430.84 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Effluent limitations representing the degree of effluent reduction attainable by the application of best available technology economically achievable (BAT). [Reserved] 430.84 Section 430.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND...

75 FR 9960 - First Trust/Aberdeen Global Opportunity Income Fund, et al.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-04

... companies to make periodic distributions of long- term capital gains with respect to their outstanding... represent that, before any Fund will implement a policy to make level, periodic distributions with respect... common stockholders with level, periodic distributions. Applicants represent that, under the Plan of a...

Improvements and validation of the erythropoiesis control model for bed rest simulation

NASA Technical Reports Server (NTRS)

Leonard, J. I.

1977-01-01

The most significant improvement in the model is the explicit formulation of separate elements representing erythropoietin production and red cell production. Other modifications include bone marrow time-delays, capability to shift oxyhemoglobin affinity and an algorithm for entering experimental data as time-varying driving functions. An area of model development is suggested by applying the model to simulating onset, diagnosis and treatment of a hematologic disorder. Recommendations for further improvements in the model and suggestions for experimental application are also discussed. A detailed analysis of the hematologic response to bed rest including simulation of the recent Baylor Medical College bed rest studies is also presented.

A study of the application of differential techniques to the global positioning system for a helicopter precision approach

NASA Technical Reports Server (NTRS)

Mccall, D. L.

1984-01-01

The results of a simulation study to define the functional characteristics of a airborne and ground reference GPS receiver for use in a Differential GPS system are doumented. The operations of a variety of receiver types (sequential-single channel, continuous multi-channel, etc.) are evaluated for a typical civil helicopter mission scenario. The math model of each receiver type incorporated representative system errors including intentional degradation. The results include the discussion of the receiver relative performance, the spatial correlative properties of individual range error sources, and the navigation algorithm used to smooth the position data.

Floristic composition and vegetation analysis in Hail region north of central Saudi Arabia

PubMed Central

El-Ghanim, Wafaa M.; Hassan, Loutfy M.; Galal, Tarek M.; Badr, Abdelfattah

2010-01-01

In this study, 19 sites representing different habitats in Hail region were regularly visited for two years, in each site 2–5 stands were selected for investigating floristic composition and vegetation types in the area. A total of 124 species representing 34 families were recorded. The family Asteraceae is represented by the highest number of species (21 species) followed by the Poaceae (17 species) and the Brassicaceae (10 species) whereas, 15 families including Acanthaceae, Convolvulaceae, Moraceae, Nyctaginaceae and Primulaceae, are represented by a single species each. Chronological analysis of the vegetation in the area revealed the domination of Saharo-Sindian elements in the wild vegetations and of weedy species in the cultivated plots. Therophytes and chamaephytes are the dominating life forms of the vegetation spectra; therophytes represent 49.20% and chamaephytes represent 29.00% of the total species in the study area. Application of TWINISPAN and DECORANA classification and ordination techniques to the data produced seven vegetation groups. Ruderal habitats comprised two small groups A and F dominated by Phragmites australis and Imperata cylindrical (A), Euphorbia peplus and Sisymbrium irio (F), respectively. Two vegetation groups (B and G) have been recognized in the mountains and slopes dominated by Launaea mucronata, Trigonella stellata (B) and Ficus palmate and Fagonia bruguieri (G). Other two groups (C and E) inhabit the desert and mountainous wadies; these are represented by Gymnocarpos decandrus and Ochradenus baccatus (C) and Senecio glaucus subsp. coronopifolius and Rumex equisetiforme (E). On the other hand, one group (D) inhabits the cultivated plots and is represented by Plantago albicans and Rumex vesicarius, the last group also includes species restricted to the sand dune habitat of the Al-Nafud desert north of Hail city and represented by Calligonum polygonoides and Halyxolon salicornicum. The vegetation analysis indicated the invasion of Hail Flora by some foreign weeds such as Solanum nigrum, Lactuca serriola and Amaranthus lividus. The presence of these weeds points out the need to monitor the vegetation change in Hail region, and also other regions of Saudi Arabia, in order to elucidate the human impact on the wild plants diversity as human activities change with the fast development in the kingdom. PMID:23961067

Evaluation of the impact of lime softening waste disposal in ...

EPA Pesticide Factsheets

Drinking water treatment residues (WTR), generated from the lime softening processes, are commonly reused or disposed of in a number of applications; these include use as a soil amendment or a subsurface fill. Recently questions were posed by the Florida regulatory community on whether lime WTR that contained a small percentage of other treatment additives could appropriately be characterized as lime WTR, in terms of its total element content and leachability. A study was done using a broad range of leaching tests, including a framework of tests recently adopted by the United States-Environmental Protection Agency (EPA) and tests that were modified to account for scenario specific conditions, such as the presence of natural organic matter (NOM). The results of these additional leaching tests demonstrated that certain applications, including disposal in a water body with NOM or in placement anaerobic environment, did result in increased leaching of elements such as Fe, and that a site specific assessment should be conducted prior to using WTR in these types of applications. This study illustrates the importance of leaching test selection when attempting to provide an estimation of release in practice. Although leaching tests are just one component in a beneficial use assessment and other factors including aquifer and soil properties play a significant role in the outcome, leaching tests should be tailored to most appropriately represent the scenario or reuse ap

Using RSAT oligo-analysis and dyad-analysis tools to discover regulatory signals in nucleic sequences.

PubMed

Defrance, Matthieu; Janky, Rekin's; Sand, Olivier; van Helden, Jacques

2008-01-01

This protocol explains how to discover functional signals in genomic sequences by detecting over- or under-represented oligonucleotides (words) or spaced pairs thereof (dyads) with the Regulatory Sequence Analysis Tools (http://rsat.ulb.ac.be/rsat/). Two typical applications are presented: (i) predicting transcription factor-binding motifs in promoters of coregulated genes and (ii) discovering phylogenetic footprints in promoters of orthologous genes. The steps of this protocol include purging genomic sequences to discard redundant fragments, discovering over-represented patterns and assembling them to obtain degenerate motifs, scanning sequences and drawing feature maps. The main strength of the method is its statistical ground: the binomial significance provides an efficient control on the rate of false positives. In contrast with optimization-based pattern discovery algorithms, the method supports the detection of under- as well as over-represented motifs. Computation times vary from seconds (gene clusters) to minutes (whole genomes). The execution of the whole protocol should take approximately 1 h.

Large eddy simulation modeling of particle-laden flows in complex terrain

NASA Astrophysics Data System (ADS)

Salesky, S.; Giometto, M. G.; Chamecki, M.; Lehning, M.; Parlange, M. B.

2017-12-01

The transport, deposition, and erosion of heavy particles over complex terrain in the atmospheric boundary layer is an important process for hydrology, air quality forecasting, biology, and geomorphology. However, in situ observations can be challenging in complex terrain due to spatial heterogeneity. Furthermore, there is a need to develop numerical tools that can accurately represent the physics of these multiphase flows over complex surfaces. We present a new numerical approach to accurately model the transport and deposition of heavy particles in complex terrain using large eddy simulation (LES). Particle transport is represented through solution of the advection-diffusion equation including terms that represent gravitational settling and inertia. The particle conservation equation is discretized in a cut-cell finite volume framework in order to accurately enforce mass conservation. Simulation results will be validated with experimental data, and numerical considerations required to enforce boundary conditions at the surface will be discussed. Applications will be presented in the context of snow deposition and transport, as well as urban dispersion.

Dynamic communities in multichannel data: an application to the foreign exchange market during the 2007-2008 credit crisis.

PubMed

Fenn, Daniel J; Porter, Mason A; McDonald, Mark; Williams, Stacy; Johnson, Neil F; Jones, Nick S

2009-09-01

We study the cluster dynamics of multichannel (multivariate) time series by representing their correlations as time-dependent networks and investigating the evolution of network communities. We employ a node-centric approach that allows us to track the effects of the community evolution on the functional roles of individual nodes without having to track entire communities. As an example, we consider a foreign exchange market network in which each node represents an exchange rate and each edge represents a time-dependent correlation between the rates. We study the period 2005-2008, which includes the recent credit and liquidity crisis. Using community detection, we find that exchange rates that are strongly attached to their community are persistently grouped with the same set of rates, whereas exchange rates that are important for the transfer of information tend to be positioned on the edges of communities. Our analysis successfully uncovers major trading changes that occurred in the market during the credit crisis.

Dynamic communities in multichannel data: An application to the foreign exchange market during the 2007-2008 credit crisis

NASA Astrophysics Data System (ADS)

Fenn, Daniel J.; Porter, Mason A.; McDonald, Mark; Williams, Stacy; Johnson, Neil F.; Jones, Nick S.

2009-09-01

We study the cluster dynamics of multichannel (multivariate) time series by representing their correlations as time-dependent networks and investigating the evolution of network communities. We employ a node-centric approach that allows us to track the effects of the community evolution on the functional roles of individual nodes without having to track entire communities. As an example, we consider a foreign exchange market network in which each node represents an exchange rate and each edge represents a time-dependent correlation between the rates. We study the period 2005-2008, which includes the recent credit and liquidity crisis. Using community detection, we find that exchange rates that are strongly attached to their community are persistently grouped with the same set of rates, whereas exchange rates that are important for the transfer of information tend to be positioned on the edges of communities. Our analysis successfully uncovers major trading changes that occurred in the market during the credit crisis.