34 CFR 300.305 - Additional requirements for evaluations and reevaluations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... determination; and (ii) The right of the parents to request an assessment to determine whether the child... STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES Evaluations, Eligibility Determinations... professionals, as appropriate, must— (1) Review existing evaluation data on the child, including— (i...

48 CFR 9.204 - Responsibilities for establishment of a qualification requirement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... requirements. If active competition on anticipated future qualification requirements is likely to be fewer than... establishing the production, quality control, or other system to be tested and evaluated) for a small business... additional qualified sources or products are likely to result in cost savings from increased competition for...

Project W-314 specific test and evaluation plan for transfer line SN-633 (241-AX-B to 241-AY-02A)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hays, W.H.

1998-03-20

The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made by the addition of the SN-633 transfer line by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the addition of transfer line SN-633. The Project Design Specificationsmore » (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation.« less

Hands-Free, Heads-Up Control System for Unmanned Ground Vehicles

DTIC Science & Technology

2011-08-10

interface evaluation Industry evaluated two commercial-off-the-shelf (COTS) brain computer interfaces from two companies – Neurosky and Emotiv ...useless, resulting in very low command recognition accuracy. In addition, latency issues plagued the system. Figure 6 Emotiv Headset The... Emotiv system, unlike the Neurosky, required great effort to use and calibrate. It requires 16 foam tips to be wet with saline solution and then

LANDSAT-D conical scanner evaluation plan

NASA Technical Reports Server (NTRS)

Bilanow, S.; Chen, L. C. (Principal Investigator)

1982-01-01

The planned activities involved in the inflight sensor calibration and performance evaluation are discussed and the supporting software requirements are specified. The possible sensor error sources and their effects on sensor measurements are summarized. The methods by which the inflight sensor performance will be analyzed and the sensor modeling parameters will be calibrated are presented. In addition, a brief discussion on the data requirement for the study is provided.

Evaluation of hybrid slurry resulting from the introduction of additives to mineral slurry.

DOT National Transportation Integrated Search

2011-09-01

Drilled shaft construction often requires the use of drill slurry to maintain borehole stability during excavation : and concreting. Florida Department of Transportation (FDOT) specifications require the use of mineral slurry : for all primary struct...

Additional Guidance for Evaluating and Calculating Degradation Kinetics in Environmental Media

EPA Pesticide Factsheets

EFED compiled examples where the PestDF (version 0.8.4), the tool used most commonly by USEPA to conduct kinetic analysis following the NAFTA guidance, results required additional interpretation. Here are some of these examples.

Engineered Barrier System performance requirements systems study report. Revision 02

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balady, M.A.

This study evaluates the current design concept for the Engineered Barrier System (EBS), in concert with the current understanding of the geologic setting to assess whether enhancements to the required performance of the EBS are necessary. The performance assessment calculations are performed by coupling the EBS with the geologic setting based on the models (some of which were updated for this study) and assumptions used for the 1995 Total System Performance Assessment (TSPA). The need for enhancements is determined by comparing the performance assessment results against the EBS related performance requirements. Subsystem quantitative performance requirements related to the EBS includemore » the requirement to allow no more than 1% of the waste packages (WPs) to fail before 1,000 years after permanent closure of the repository, as well as a requirement to control the release rate of radionuclides from the EBS. The EBS performance enhancements considered included additional engineered components as well as evaluating additional performance available from existing design features but for which no performance credit is currently being taken.« less

42 CFR 412.27 - Excluded psychiatric units: Additional requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... descriptive, not interpretative fashion. (3) Treatment plan. (i) Each inpatient must have an individual... staff to evaluate inpatients, formulate written, individualized, comprehensive treatment plans, provide... personnel to— (i) Evaluate inpatients; (ii) Formulate written, individualized, comprehensive treatment plans...

42 CFR 412.27 - Excluded psychiatric units: Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... descriptive, not interpretative fashion. (3) Treatment plan. (i) Each inpatient must have an individual... staff to evaluate inpatients, formulate written, individualized, comprehensive treatment plans, provide... personnel to— (i) Evaluate inpatients; (ii) Formulate written, individualized, comprehensive treatment plans...

42 CFR 412.27 - Excluded psychiatric units: Additional requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... descriptive, not interpretative fashion. (3) Treatment plan. (i) Each inpatient must have an individual... staff to evaluate inpatients, formulate written, individualized, comprehensive treatment plans, provide... personnel to— (i) Evaluate inpatients; (ii) Formulate written, individualized, comprehensive treatment plans...

42 CFR 412.27 - Excluded psychiatric units: Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... descriptive, not interpretative fashion. (3) Treatment plan. (i) Each inpatient must have an individual... staff to evaluate inpatients, formulate written, individualized, comprehensive treatment plans, provide... personnel to— (i) Evaluate inpatients; (ii) Formulate written, individualized, comprehensive treatment plans...

42 CFR 412.27 - Excluded psychiatric units: Additional requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... descriptive, not interpretative fashion. (3) Treatment plan. (i) Each inpatient must have an individual... staff to evaluate inpatients, formulate written, individualized, comprehensive treatment plans, provide... personnel to— (i) Evaluate inpatients; (ii) Formulate written, individualized, comprehensive treatment plans...

Evaluation of certain food additives and contaminants.

PubMed

2001-01-01

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives and contaminants, with a view to recommending Acceptable Daily Intakes (ADIs) and tolerable intakes, respectively, and to prepare specifications for the identity and purity of food additives. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of food additives and contaminants (including flavouring agents), and the establishment and revision of specifications. A summary follows of the Committee's evaluations of toxicological data on various specific food additives (furfural, paprika oleoresin, caramel colour II, cochineal extract, carmines, aspartame-acesulfame salt, D-tagatose, benzoyl peroxide, nitrous oxide, stearyl tartrate and trehalose), flavouring agents and contaminants (cadmium and tin), and of intake data on calcium from calcium salts of food additives. Annexed to the report are tables summarizing the Committee's recommendations for ADIs of the food additives and tolerable intakes of the contaminants considered, changes in the status of specifications of these food additives and specific flavouring agents, and further information required or desired.

Flammability, Odor, Offgassing, and Compatibility Requirements and Test Procedures for Materials in Environments that Support Combustion

NASA Technical Reports Server (NTRS)

1998-01-01

This handbook establishes NASA program requirements for evaluation, testing, and selection of materials to preclude unsafe conditions related to flammability, odor, offgassing, and fluid compatibility. Materials intended for use in space vehicles, specified test facilities, and specified ground support equipment (GSE) must meet the requirements of this document. Additional materials performance requirements may be specified in other program or NASA center specific documentation. Responsible NASA centers materials organizations must include applicable requirements of this document in their materials control programs. Materials used in habitable areas of spacecraft, including the materials of the spacecraft, stowed equipment, and experiments, must be evaluated for flammability, odor, and offgassing characteristics. All materials used in other areas must be evaluated for flammability characteristics. In addition, materials that are exposed to liquid oxygen (LOX), gaseous oxygen (GOX), and other reactive fluids' must be evaluated for compatibility with the fluid in their use application. Materials exposed to pressurized breathing gases also must be evaluated for odor and offgassing characteristics. The worst-case anticipated use environment (most hazardous pressure, temperature, material thickness, and fluid exposure conditions) must be used in the evaluation process. Materials that have been shown to meet the criteria of the required tests are acceptable for further consideration in design. Whenever possible, materials should be selected that have already been shown to meet the test criteria in the use environment. Existing test data are compiled in the NASA Marshall Space Flight Center (MSFC) Materials and Processes Technical Information System (MAPTIS) and published periodically as the latest revision of a joint document with Johnson Space Center (JSC), MSFC-HDBK-527/JSC 09604. MAPTIS can be accessed by computer datalink. Systems containing materials that have not been tested or do not meet the criteria of the required tests must be verified to be acceptable in the use configuration by analysis or testing. This verification rationale must be documented and submitted to the responsible NASA center materials organization for approval.

[Imaging of traumatic injuries of the knee].

PubMed

Blin, D; Cyteval, C; Kamba, C; Blondel, M; Lopez, F M

2007-05-01

Traumatic injuries to the knee are frequent (road or sports related accidents, falls in elderly people). The Ottawa knee rules are applied and dictate the need for additional evaluation. Some fractures are adequately assessed on plain radiographs alone whereas other fractures (tibial plateau fracture) require additional evaluation with CT. Some fractures may be occult: the significance of lipohemarthrosis (indirect sign of intra-articular fracture on the lateral radiograph with horizontal beam) must be known. Benign appearing avulsion fractures suggest the presence of underlying capsuloligamentous injuries requiring further evaluation with MRI. The imaging work-up of sprains is usually negative. MRI may show areas of bone contusion that further the understanding of the mechanism of injury, predict and confirm the presence of capsuloligamentous injuries. Angiography is performed to detect popliteal artery injuries after knee dislocation which is associated with a risk of ischemia.

Evaluation of 12 blood glucose monitoring systems for self-testing: system accuracy and measurement reproducibility.

PubMed

Freckmann, Guido; Baumstark, Annette; Schmid, Christina; Pleus, Stefan; Link, Manuela; Haug, Cornelia

2014-02-01

Systems for self-monitoring of blood glucose (SMBG) have to provide accurate and reproducible blood glucose (BG) values in order to ensure adequate therapeutic decisions by people with diabetes. Twelve SMBG systems were compared in a standardized manner under controlled laboratory conditions: nine systems were available on the German market and were purchased from a local pharmacy, and three systems were obtained from the manufacturer (two systems were available on the U.S. market, and one system was not yet introduced to the German market). System accuracy was evaluated following DIN EN ISO (International Organization for Standardization) 15197:2003. In addition, measurement reproducibility was assessed following a modified TNO (Netherlands Organization for Applied Scientific Research) procedure. Comparison measurements were performed with either the glucose oxidase method (YSI 2300 STAT Plus™ glucose analyzer; YSI Life Sciences, Yellow Springs, OH) or the hexokinase method (cobas(®) c111; Roche Diagnostics GmbH, Mannheim, Germany) according to the manufacturer's measurement procedure. The 12 evaluated systems showed between 71.5% and 100% of the measurement results within the required system accuracy limits. Ten systems fulfilled with the evaluated test strip lot minimum accuracy requirements specified by DIN EN ISO 15197:2003. In addition, accuracy limits of the recently published revision ISO 15197:2013 were applied and showed between 54.5% and 100% of the systems' measurement results within the required accuracy limits. Regarding measurement reproducibility, each of the 12 tested systems met the applied performance criteria. In summary, 83% of the systems fulfilled with the evaluated test strip lot minimum system accuracy requirements of DIN EN ISO 15197:2003. Each of the tested systems showed acceptable measurement reproducibility. In order to ensure sufficient measurement quality of each distributed test strip lot, regular evaluations are required.

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

TWRS authorization basis configuration control summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendoza, D.P.

This document was developed to define the Authorization Basis management functional requirements for configuration control, to evaluate the management control systems currently in place, and identify any additional controls that may be required until the TWRS [Tank Waste Remediation System] Configuration Management system is fully in place.

Evaluation of novophalt as an additive in asphalt.

DOT National Transportation Integrated Search

1991-01-01

Novophalt, which is an ethylene vinyl acetate polymer, was used as an asphalt additive in a test section in an attempt to determine whether it is useful in the prevention of rutting. A special blending unit was required to blend the asphalt cement an...

Thermal Control Working Group report

NASA Technical Reports Server (NTRS)

Haslett, Robert; Mahefkey, E. Thomas

1986-01-01

The Thermal Control Working Group limited its evaluation to issues associated with Earth orbiting and planetary spacecraft with power levels up to 50 kW. It was concluded that the space station technology is a necessary precursor but does not meet S/C 2000 needs (life, high heat flux, long term cryogenics, and survivability). Additional basic and applied research are required (fluid/materials compatibility and two phase system modeling). Scaling, the key issue, must define accelerated life test criteria. The two phase systems require 0g to 1 g correlation. Additional ground test beds are required and combined space environment tests of materials.

Engineering and fabrication cost considerations for cryogenic wind tunnel models

NASA Technical Reports Server (NTRS)

Boykin, R. M., Jr.; Davenport, J. B., Jr.

1983-01-01

Design and fabrication cost drivers for cryogenic transonic wind tunnel models are defined. The major cost factors for wind tunnel models are model complexity, tolerances, surface finishes, materials, material validation, and model inspection. The cryogenic temperatures require the use of materials with relatively high fracture toughness but at the same time high strength. Some of these materials are very difficult to machine, requiring extensive machine hours which can add significantly to the manufacturing costs. Some additional engineering costs are incurred to certify the materials through mechanical tests and nondestructive evaluation techniques, which are not normally required with conventional models. When instrumentation such as accelerometers and electronically scanned pressure modules is required, temperature control of these devices needs to be incorporated into the design, which requires added effort. Additional thermal analyses and subsystem tests may be necessary, which also adds to the design costs. The largest driver to the design costs is potentially the additional static and dynamic analyses required to insure structural integrity of the model and support system.

Traverse Planning Experiments for Future Planetary Surface Exploration

NASA Technical Reports Server (NTRS)

Hoffman, Stephen J.; Voels, Stephen A.; Mueller, Robert P.; Lee, Pascal C.

2012-01-01

The purpose of the investigation is to evaluate methodology and data requirements for remotely-assisted robotic traverse of extraterrestrial planetary surface to support human exploration program, assess opportunities for in-transit science operations, and validate landing site survey and selection techniques during planetary surface exploration mission analog demonstration at Haughton Crater on Devon Island, Nunavut, Canada. Additionally, 1) identify quality of remote observation data sets (i.e., surface imagery from orbit) required for effective pre-traverse route planning and determine if surface level data (i.e., onboard robotic imagery or other sensor data) is required for a successful traverse, and if additional surface level data can improve traverse efficiency or probability of success (TRPF Experiment). 2) Evaluate feasibility and techniques for conducting opportunistic science investigations during this type of traverse. (OSP Experiment). 3) Assess utility of remotely-assisted robotic vehicle for landing site validation survey. (LSV Experiment).

78 FR 77428 - 2014 Annual Determination for Sea Turtle Observer Requirement

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-23

... Determination for Sea Turtle Observer Requirement AGENCY: National Marine Fisheries Service (NMFS), National... observing identified fisheries is to learn more about sea turtle interactions in a given fishery, evaluate existing measures to prevent or reduce prohibited sea turtle takes, and to determine whether additional...

77 FR 75999 - 2013 Annual Determination for Sea Turtle Observer Requirement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... Determination for Sea Turtle Observer Requirement AGENCY: National Marine Fisheries Service (NMFS), National... observing identified fisheries is to learn more about sea turtle interactions in a given fishery, evaluate existing measures to prevent or reduce prohibited sea turtle takes, and to determine whether additional...

Evaluation of the use of rubber-tire rollers on asphalt concrete.

DOT National Transportation Integrated Search

1989-01-01

The addition of a rubber-tire roller was required on two projects on maintenance schedules and on two construction projects in 1988. The rubber-tire roller was used as an addition to the conventional rollers on one-half of each project. The rubber-ti...

Ethanol production in small- to medium-size facilities

NASA Astrophysics Data System (ADS)

Hiler, E. A.; Coble, C. G.; Oneal, H. P.; Sweeten, J. M.; Reidenbach, V. G.; Schelling, G. T.; Lawhon, J. T.; Kay, R. D.; Lepori, W. A.; Aldred, W. H.

1982-04-01

In early 1980 system design criteria were developed for a small-scale ethanol production plant. The plant was eventually installed on November 1, 1980. It has a production capacity of 30 liters per hour; this can be increased easily (if desired) to 60 liters per hour with additional fermentation tanks. Sixty-six test runs were conducted to date in the alcohol production facility. Feedstocks evaluated in these tests include: corn (28 runs); grain sorghum (33 runs); grain sorghum grits (1 run); half corn/half sorghum (1 run); and sugarcane juice (3 runs). In addition, a small bench-scale fermentation and distillation system was used to evaluate sugarcane and sweet sorghum feedstocks prior to their evaluation in the larger unit. In each of these tests, evaluation of the following items was conducted: preprocessing requirements; operational problems; conversion efficiency (for example, liters of alcohol produced per kilogram of feedstock); energy balance and efficiency; nutritional recovery from stillage; solids separation by screw press; chemical characterization of stillage including liquid and solids fractions; wastewater requirements; and air pollution potential.

Estimating force and power requirements for crosscut shearing of roundwood.

Treesearch

Rodger A. Arola

1972-01-01

Presents a procedure which, through the use of nomographs, permits rapid estimation of the force required to crosscut shear logs of various species and diameters with shear blades ranging in thickness from 1/4 to 7/8 inch. In addition, nomographs are included to evaluate hydraulic cylinder sizes, pump capacities, and motor horsepower requirements to effect the cut....

An overview of NASA testing requirements for alternate cleaning solvents used in liquid and gaseous oxygen environments

NASA Technical Reports Server (NTRS)

Strickland, John W.; Davis, S. Eddie

1995-01-01

The elimination of CFC-containing cleaning solvents for oxygen systems has prompted the development of a number of alternative cleaning solvents that must now be evaluated not only for cleanability, but compatibility as well. NASA Handbook 8060.1(NHB 8060.1) establishes the requirements for evaluation, testing, and selection of materials for use in oxygen rich environments. Materials intended for use in space vehicles, specified test facilities, and ground support equipment must meet the requirements of this document. In addition to the requirements of NHB 8060.1 for oxygen service, alternative cleaning solvents must also be evaluated in other areas (such as corrosivity, non-metals compatibility, non-volatile residue contamination, etc.). This paper will discuss the testing requirements of NHB 8060.1 and present preliminary results from early screening tests performed at Marshall Space Flight Center's Materials Combustion Research Facility.

Smoothing PV System’s Output by Tuning MPPT Control

NASA Astrophysics Data System (ADS)

Ina, Nobuhiko; Yanagawa, Shigeyuki; Kato, Takeyoshi; Suzuoki, Yasuo

A PV system’s output is not stable and fluctuates depending on a weather condition. Using a battery is one of the feasible ways to stabilize a PV system’s output, although it requires an additional cost and provides an additional waste of the used battery. In this paper, we propose tuning a characteristic of Maxiumum Power Point Tracking (MPPT) control for smoothing a short term change of PV system’s output during a sharp insolation fluctuation, as an approach without additional equipments. In our proposed method, when an insolation increases rapidly, the operation point of MPPT control changes to the new point where the maximum power is not generated with present insolation, so that the speed of PV system’s output increase is limited to a certain value, i. e. 1%/min. In order to evaluate the effect of our proposed method in terms of reducing the additional operation task of the electric power system, we evaluated the additional LFC capacity for a large-scale installation of PV systems. As a result, it was revealed that the additional LFC capacity is not required even if a PV system is installed by 5% of utility system, when our proposed method is applied to all PV systems.

Development of water quality standards criteria. [for consumables (spacecrew supplies)

NASA Technical Reports Server (NTRS)

1976-01-01

Qualitative and semiquantitative analyses were made of volatile organic compounds in water supplies collected at various stages of processing in the space station prototype vacuum compression distillation unit to evaluate the process and the product water. Additional evaluation was made of specific ingredients required to adequately enhance the taste of the reclaimed water. A concept for the in-flight addition of these ingredients was developed. Revisions to previously recommended potable water criteria and specifications are included.

Operational Area Environmental Evaluations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bailey-White, Brenda Eileen; Nagy, Michael David; Wagner, Katrina Marie

The Operational Area Environmental Evaluation update provides a description of activities that have the potential to adversely affect natural and cultural resources, including soil, air, water, biological, ecological, and historical resources. The environmental sensitivity of an area is evaluated and summarized, which may facilitate informed management decisions as to where development may be prohibited, restricted, or subject to additional requirements.

Accessibility and usability OCW data: The UTPL OCW.

PubMed

Rodríguez, Germania; Perez, Jennifer; Cueva, Samanta; Torres, Rommel

2017-08-01

This data article provides a data description on article entitled "A framework for improving web accessibility and usability of Open Course Ware sites" [3] This Data in Brief presents the data obtained from the accessibility and usability evaluation of the UTPL OCW. The data obtained from the framework evaluation consists of the manual evaluation of the standards criteria and the automatic evaluation of the tools Google PageSpeed and Google Analytics. In addition, this article presents the synthetized tables from standards that are used by the framework to evaluate the accessibility and usability of OCW, and the questionnaires required to extract the data. As a result, the article also provides the data required to reproduce the evaluation of other OCW.

ATM kinase is required for telomere elongation in mouse and human cells

PubMed Central

Lee, Stella Suyong; Bohrson, Craig; Pike, Alexandra Mims; Wheelan, Sarah Jo; Greider, Carol Widney

2015-01-01

Summary Short telomeres induce a DNA damage response, senescence and apoptosis; thus, maintaining telomere length equilibrium is essential for cell viability. Telomerase addition of telomere repeats is tightly regulated in cells. To probe pathways that regulate telomere addition, we developed the ADDIT assay to measure new telomere addition at a single telomere in vivo. Sequence analysis showed telomerase specific addition of repeats onto a new telomere occurred in just 48 hr. Using the ADDIT assay, we found that ATM is required for addition of new repeats onto telomeres in mouse cells. Evaluation of bulk telomeres, in both human and mouse cells, showed that blocking ATM inhibited telomere elongation. Finally, the activation of ATM through the inhibition of PARP1 resulted in increased telomere elongation, supporting the central role of the ATM pathway in regulating telomere addition. Understanding this role of ATM may yield new areas for possible therapeutic intervention in telomere-mediated disease. PMID:26586427

High School Graduation Minimum Competency Requirements. Final Technical Report.

ERIC Educational Resources Information Center

Austin Independent School District, TX. Office of Research and Evaluation.

This technical report details the testing results and analyses supporting the evaluation findings related to the Austin (Texas) Independent School District (AISD) minimum competency graduation requirements. The graduation competency status of all AISD students in grades 8 to 12 are documented. The report provides additional information on the data…

77 FR 474 - 2012 Annual Determination for Sea Turtle Observer Requirement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-05

... Determination for Sea Turtle Observer Requirement AGENCY: National Marine Fisheries Service (NMFS), National... identified fisheries is to learn more about sea turtle interactions in a given fishery, evaluate existing measures to prevent or reduce prohibited sea turtle takes, and to determine whether additional measures to...

34 CFR 379.45 - What are the additional reporting requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION PROJECTS WITH INDUSTRY What... must submit the data from its annual evaluation of project operations required under § 379.21(a)(5) no later than 60 days after the end of each project year, unless the Secretary authorizes a later...

40 CFR 57.503 - Control measures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Control measures. 57.503 Section 57.503... NONFERROUS SMELTER ORDERS Fugitive Emission Evaluation and Control § 57.503 Control measures. The NSO of any... requirement of § 57.501. Measures required to be implemented may include: (a) Additional supplementary control...

40 CFR 57.503 - Control measures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 6 2012-07-01 2012-07-01 false Control measures. 57.503 Section 57.503... NONFERROUS SMELTER ORDERS Fugitive Emission Evaluation and Control § 57.503 Control measures. The NSO of any... requirement of § 57.501. Measures required to be implemented may include: (a) Additional supplementary control...

40 CFR 57.503 - Control measures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Control measures. 57.503 Section 57.503... NONFERROUS SMELTER ORDERS Fugitive Emission Evaluation and Control § 57.503 Control measures. The NSO of any... requirement of § 57.501. Measures required to be implemented may include: (a) Additional supplementary control...

40 CFR 57.503 - Control measures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 6 2014-07-01 2014-07-01 false Control measures. 57.503 Section 57.503... NONFERROUS SMELTER ORDERS Fugitive Emission Evaluation and Control § 57.503 Control measures. The NSO of any... requirement of § 57.501. Measures required to be implemented may include: (a) Additional supplementary control...

44 CFR 65.9 - Review and response by the Administrator.

Code of Federal Regulations, 2011 CFR

2011-10-01

... questions or problems arise during review, FEMA will consult the Chief Executive Officer of the community (CEO), the community official designated by the CEO, and/or the requester for resolution. Upon receipt... additional 90 days is required to evaluate the scientific or technical data submitted; or (g) Additional data...

44 CFR 65.9 - Review and response by the Administrator.

Code of Federal Regulations, 2010 CFR

2010-10-01

... questions or problems arise during review, FEMA will consult the Chief Executive Officer of the community (CEO), the community official designated by the CEO, and/or the requester for resolution. Upon receipt... additional 90 days is required to evaluate the scientific or technical data submitted; or (g) Additional data...

Flat-plate solar array project. Volume 6: Engineering sciences and reliability

NASA Technical Reports Server (NTRS)

Ross, R. G., Jr.; Smokler, M. I.

1986-01-01

The Flat-Plate Solar Array (FSA) Project activities directed at developing the engineering technology base required to achieve modules that meet the functional, safety, and reliability requirements of large scale terrestrial photovoltaic systems applications are reported. These activities included: (1) development of functional, safety, and reliability requirements for such applications; (2) development of the engineering analytical approaches, test techniques, and design solutions required to meet the requirements; (3) synthesis and procurement of candidate designs for test and evaluation; and (4) performance of extensive testing, evaluation, and failure analysis of define design shortfalls and, thus, areas requiring additional research and development. A summary of the approach and technical outcome of these activities are provided along with a complete bibliography of the published documentation covering the detailed accomplishments and technologies developed.

Evaluative stimulus (in)congruency impacts performance in an unrelated task: evidence for a resource-based account of evaluative priming.

PubMed

Gast, Anne; Werner, Benedikt; Heitmann, Christina; Spruyt, Adriaan; Rothermund, Klaus

2014-01-01

In two experiments, we assessed evaluative priming effects in a task that was unrelated to the congruent or incongruent stimulus pairs. In each trial, participants saw two valent (positive or negative) pictures that formed evaluatively congruent or incongruent stimulus pairs and a letter that was superimposed on the second picture. Different from typical evaluative priming studies, participants were not required to respond to the second of the valent stimuli, but asked to categorize the letter that was superimposed on the second picture. We assessed the impact of the evaluative (in)congruency of the two pictures on the performance in responding to the letter. In addition, we manipulated attention to the evaluative dimension by asking participants in one experimental group to respond to the valence of the pictures on a subset of trials (evaluative task condition). In both experiments, we found evaluative priming effects in letter categorization responses: Participants categorized the letter faster (and sometimes more correctly) in trials with congruent picture-pairs. These effects were present only in the evaluative task condition. These findings can be explained with different resource-based accounts of evaluative priming and the additional assumption that attention to valence is necessary for evaluative congruency to affect processing resources. According to resource-based accounts valence-incongruent trials require more cognitive resources than valence-congruent trials (e.g., Hermans, Van den Broeck, & Eelen, 1998).

Technology and development requirements for advanced coal conversion systems

NASA Technical Reports Server (NTRS)

1981-01-01

A compendium of coal conversion process descriptions is presented. The SRS and MC data bases were utilized to provide information paticularly in the areas of existing process designs and process evaluations. Additional information requirements were established and arrangements were made to visit process developers, pilot plants, and process development units to obtain information that was not otherwise available. Plant designs, process descriptions and operating conditions, and performance characteristics were analyzed and requirements for further development identified and evaluated to determine the impact of these requirements on the process commercialization potential from the standpoint of economics and technical feasibility. A preliminary methodology was established for the comparative technical and economic assessment of advanced processes.

Advanced life support study

NASA Technical Reports Server (NTRS)

1991-01-01

Summary reports on each of the eight tasks undertaken by this contract are given. Discussed here is an evaluation of a Closed Ecological Life Support System (CELSS), including modeling and analysis of Physical/Chemical Closed Loop Life Support (P/C CLLS); the Environmental Control and Life Support Systems (ECLSS) evolution - Intermodule Ventilation study; advanced technologies interface requirements relative to ECLSS; an ECLSS resupply analysis; the ECLSS module addition relocation systems engineering analysis; an ECLSS cost/benefit analysis to identify rack-level interface requirements of the alternate technologies evaluated in the ventilation study, with a comparison of these with the rack level interface requirements for the baseline technologies; advanced instrumentation - technology database enhancement; and a clean room survey and assessment of various ECLSS evaluation options for different growth scenarios.

Evaluation of methodology for detecting/predicting migration of forest species

Treesearch

Dale S. Solomon; William B. Leak

1996-01-01

Available methods for analyzing migration of forest species are evaluated, including simulation models, remeasured plots, resurveys, pollen/vegetation analysis, and age/distance trends. Simulation models have provided some of the most drastic estimates of species changes due to predicted changes in global climate. However, these models require additional testing...

Redesigning an Introductory Language Curriculum: A Backward Design Approach

ERIC Educational Resources Information Center

Paesani, Kate

2017-01-01

In response to calls for curricular change in foreign language programs and institutional requirements to evaluate programmatic effectiveness, this article presents a backward design approach to the redesign of an introductory French curriculum grounded in the framing concept of cultural literacy. In addition, data from student evaluations,…

Pheochromocytoma in Urologic Practice

PubMed Central

Waingankar, Nikhil; Bratslavsky, Gennady; Jimenez, Camilo; Russo, Paul; Kutikov, Alexander

2016-01-01

Context Pheochromocytoma is regularly encountered in urological practice and requires a thoughtful and careful clinical approach. Objective To review clinical aspects of management of pheochromocytoma in urologic practice. Evidence Acquisition A systematic review of English-language literature was performed through year 2015 using the Medline database. Manuscripts were selected with consensus of the coauthors and evaluated using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) criteria. Evidence Synthesis Findings and recommendations of the evaluated manuscripts are discussed with an emphasis on the description of presentation, diagnosis, evaluation, and perioperative care. Conclusion In addition to surgical expertise, appropriate management of pheochromocytoma in urologic practice requires nuanced understanding of pathophysiology, genetics, and endocrinological principles. When skillfully managed, the vast majority of patients with pheochromocytoma should expect an excellent prognosis. Patient Summary In this article we review the clinical approach to patients with pheochromocytoma, a tumor that stems from the innermost part of the adrenal gland and that often secretes excessive amounts of powerful hormones such as noradrenaline and adrenaline. Significant expertise is required to appropriately manage patients with these tumors. Take Home Message In addition to surgical expertise, appropriate management of pheochromocytoma in urologic practice requires nuanced understanding of pathophysiology, genetics, and endocrinological principles. When skillfully managed, vast majority of patients with pheochromocytoma should expect an excellent prognosis. PMID:28078330

[Experiences and recommendations of the German Federal Institute for Drugs and Medical Devices (BfArM) concerning clinical investigation of medical devices and the evaluation of serious adverse events (SAE)].

PubMed

Renisch, B; Lauer, W

2014-12-01

An integral part of the conformity assessment process for medical devices is a clinical evaluation based on clinical data. Particularly in the case of implantable devices and products of risk class III clinical trials must be performed. Since March 2010 applications for the authorization of clinical trials as well as for the waiver of the authorization requirement must be submitted centrally in Germany to the appropriate federal authority, the Federal Institute for Drugs and Medical Devices (BfArM) or the Paul Ehrlich Institute (PEI). In addition to authorization, approval by the responsible ethics committee is also required under law in order to begin clinical testing of medical devices in Germany. In this paper, the legal framework for the clinical testing of medical devices as well as those involved and possible procedures including evaluation criteria for the initial application of a trial and subsequent amendments are presented in detail. In addition, the reporting requirements for serious adverse events (SAEs) are explained and possible consequences of the evaluation are presented. Finally, a summary of application and registration numbers for all areas of extensive experience of the BfArM as well as requests and guidance for applicants are presented.

38 CFR 74.11 - How does CVE process applications for VetBiz VIP Verification Program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... electronic means. (The Office of Management and Budget has approved the information collection requirements... Veterans Enterprise, is authorized to approve or deny applications for VetBiz VIP Verification. The CVE... complete and suitable for evaluation and, if not, what additional information or clarification is required...

38 CFR 74.11 - How does CVE process applications for VetBiz VIP Verification Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... electronic means. (The Office of Management and Budget has approved the information collection requirements... Veterans Enterprise, is authorized to approve or deny applications for VetBiz VIP Verification. The CVE... complete and suitable for evaluation and, if not, what additional information or clarification is required...

38 CFR 74.11 - How does CVE process applications for VetBiz VIP Verification Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... electronic means. (The Office of Management and Budget has approved the information collection requirements... Veterans Enterprise, is authorized to approve or deny applications for VetBiz VIP Verification. The CVE... complete and suitable for evaluation and, if not, what additional information or clarification is required...

38 CFR 74.11 - How does CVE process applications for VetBiz VIP Verification Program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... electronic means. (The Office of Management and Budget has approved the information collection requirements... Veterans Enterprise, is authorized to approve or deny applications for VetBiz VIP Verification. The CVE... complete and suitable for evaluation and, if not, what additional information or clarification is required...

38 CFR 74.11 - How does CVE process applications for VetBiz VIP Verification Program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... electronic means. (The Office of Management and Budget has approved the information collection requirements... Veterans Enterprise, is authorized to approve or deny applications for VetBiz VIP Verification. The CVE... complete and suitable for evaluation and, if not, what additional information or clarification is required...

40 CFR 80.161 - Detergent additive certification program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the subject detergent additive in each test fuel, and the corresponding test results (percent flow... penalties in §§ 80.169 and 80.172. (iii) If both parties submit the required information, EPA will evaluate... customers who use the disqualified detergent. Failure to do so may subject the certifier to liabilities for...

78 FR 59265 - FD&C Yellow No. 5; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... (NAICS code 112). Food manufacturing (NAICS code 311). Pesticide manufacturing (NAICS code 32532). B. How.... 5 is a FDA permanently listed color additive used in food, drugs and cosmetics, including drugs and cosmetics for the eye area. FDA's color additive evaluation included the consideration of an extensive set...

30 CFR 18.32 - Fastenings-additional requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction... or for making electrical connections. (g) The acceptable sizes for and spacings of fastenings shall...

Shuttle/Agena study. Volume 2, part 1: Program requirements, conclusions, recommendations

NASA Technical Reports Server (NTRS)

1972-01-01

An evaluation to determine the compatibility of the Agena with the space transportation system for use as an expendable third stage to the space shuttle was conducted. The Agena was considered for those missions requiring additional propulsion capability beyond that used for low earth orbit. The study defines the interface requirements imposed on both the Agena and the shuttle system and identifies those areas where the Agena must be improved or modified to satisfy mission requirements.

Nickel-metal hydride (Ni-MH) technology evaluation for aircraft battery applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loeber, G.; Vukson, S.P.; Erbacher, J.K.

1996-12-31

Available cylindrical and prismatic commercial Ni-MH batteries using AB{sub 5} and AB{sub 2} cathodes were evaluated for possible application to military aircraft batteries. Commercial AB{sub 5} technology is further advanced than AB{sub 2} technology and would require less alloy, electrolyte and single cell/battery development for near term (3--5 years) applications. Tested AB{sub 2} technology appears inadequate to meet the near term military requirements and would require a major development in the alloy to overcome the irreversible capacity loss at temperatures above 49 C. In addition, significant advances in alloy, electrolyte and single cell/battery development would also be needed.

Microgravity Workstation and Restraint Evaluations

NASA Technical Reports Server (NTRS)

Chmielewski, C.; Whitmore, M.; Mount, F.

1999-01-01

Confined workstations, where the operator has limited visibility and physical access to the work area, may cause prolonged periods of unnatural posture. Impacts on performance, in terms of fatigue and posture, may occur especially if the task is tedious and repetitive or requires static muscle loading. The glovebox design is a good example of the confined workstation concept. Within the scope of the 'Microgravity Workstation and Restraint Evaluation' project, funded by the NASA Headquarters Life Sciences Division, it was proposed to conduct a series of evaluations in ground, KC-135 and Shuttle environments to investigate the human factors issues concerning confined/unique workstations, such as gloveboxes, and also including crew restraint requirements. As part of the proposed integrated evaluations, two Shuttle Detailed Supplementary Objectives (DSOs) were manifested; one on Space Transportation System (STS)-90 and one on STS-88. The DSO on STS-90 evaluated use of the General Purpose Workstation (GPWS). The STS-88 mission was planned to evaluate a restraint system at the Remote Manipulator System (RMS). In addition, KC- 1 35 flights were conducted to investigate user/workstation/restraint integration for long-duration microgravity use. The scope of these evaluations included workstations and restraints to be utilized in the ISS environment, but also incorporated other workstations/ restraints in an attempt to provide findings/requirements with broader applications across multiple programs (e.g., Shuttle, ISS, and future Lunar-Mars programs). In addition, a comprehensive electronic questionnaire has been prepared and is under review by the Astronaut Office which will compile crewmembers' lessons learned information concerning glovebox and restraint use following their missions. These evaluations were intended to be complementary and were coordinated with hardware developers, users (crewmembers), and researchers. This report is intended to provide a summary of the findings from each of the evaluations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richer, Jeff; Frimeth, Jeff; Nesbitt, James

Purpose: In Ontario, shielding for all X-ray machines, including CT scanners, must be evaluated according to Safety Code 20A (Health Canada, 1983) which is based on NCRP-49 (NCRP, 1976). NCRP-147 (NCRP, 2004) is the international standard for shielding calculations of CT scanners and is also referenced in Safety Code 35 (Health Canada, 2008) which, was published to supersede SC20A. The goal of this work is to demonstrate the cost effectiveness of NCRP-147 for CT scanner shielding. Methods: CT scanner shielding calculations are performed using SC20A and NCRP-147: A room located on the third floor with the nearest building 75m awaymore » A room with high occupancy uncontrolled adjacent spaces Two side by side rooms on the main floor Results: 1. SC20A: The exterior windows required 0.1mm of Pb to protect the public who may occupy the building at 75m. 1. NCRP-147: No additional shielding required. 2. SC20A: Two walls adjacent to high occupancy uncontrolled space required an additional 1.58mm Pb. 2. NCRP-147: No additional shielding required. 3. SC20A: The entire floor and ceiling slabs in both rooms required an additional 0.79mm Pb. In addition, 0.79mm Pb was added to the walls from the ceiling to overlap the existing Pb shielding in the walls. 3. NCRP-147: No additional shielding required. Conclusion: The application of NCRP Report No. 147 affords the required protection to staff and the public, in the true spirit of the ALARA principle, taking into account relevant social and economic factors.« less

PRELIMINARY EVALUATION OF DWPF IMPACTS OF BORIC ACID USE IN CESIUM STRIP FOR SWPF AND MCU

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, M.

2010-09-28

A new solvent system is being evaluated for use in the Modular Caustic-Side Solvent Extraction Unit (MCU) and in the Salt Waste Processing Facility (SWPF). The new system includes the option to replace the current dilute nitric acid strip solution with boric acid. To support this effort, the impact of using 0.01M, 0.1M, 0.25M and 0.5M boric acid in place of 0.001M nitric acid was evaluated for impacts on the DWPF facility. The evaluation only covered the impacts of boric acid in the strip effluent and does not address the other changes in solvents (i.e., the new extractant, called MaxCalix,more » or the new suppressor, guanidine). Boric acid additions may lead to increased hydrogen generation during the SRAT and SME cycles as well as change the rheological properties of the feed. The boron in the strip effluent will impact glass composition and could require each SME batch to be trimmed with boric acid to account for any changes in the boron from strip effluent additions. Addition of boron with the strip effluent will require changes in the frit composition and could lead to changes in melt behavior. The severity of the impacts from the boric acid additions is dependent on the amount of boric acid added by the strip effluent. The use of 0.1M or higher concentrations of boric acid in the strip effluent was found to significantly impact DWPF operations while the impact of 0.01M boric acid is expected to be relatively minor. Experimental testing is required to resolve the issues identified during the preliminary evaluation. The issues to be addressed by the testing are: (1) Impact on SRAT acid addition and hydrogen generation; (2) Impact on melter feed rheology; (3) Impact on glass composition control; (4) Impact on frit production; and (5) Impact on melter offgas. A new solvent system is being evaluated for use in the Modular Caustic-Side Solvent Extraction Unit (MCU) and in the Salt Waste Processing Facility (SWPF). The new system includes the option to replace the current dilute nitric acid strip solution with boric acid. To support this effort, the impact of using 0.01M, 0.1M, 0.25M and 0.5M boric acid in place of 0.001M nitric acid was evaluated for impacts on the DWPF facility. The evaluation only covered the impacts of boric acid in the strip effluent and does not address the other changes in solvents (i.e., the new extractant, called MaxCalix, or the new suppressor, guanidine). Experimental testing with the improved solvent is required to determine the impact of any changes in the entrained solvent on DWPF processing.« less

Advanced Extravehicular Protective System (AEPS) study

NASA Technical Reports Server (NTRS)

Williams, J. L.; Webbon, B. W.; Copeland, R. J.

1972-01-01

A summary is presented of Advanced Extravehicular Protective Systems (AEPS) for the future missions beyond Skylab in earth orbit, on the lunar surface, and on the Martian surface. The study concentrated on the origination of regenerable life support concepts for use in portable extravehicular protective systems, and included evaluation and comparison with expendable systems, and selection of life support subsystems. The study was conducted in two phases. In the first phase, subsystem concepts for performing life support functions in AEPS which are regenerable or partially regenerable were originated, and in addition, expendable subsystems were considered. Parametric data for each subsystem concept were evolved including subsystem weight and volume, power requirement, thermal control requirement; base regeneration equipment weight and volume, requirement. The second phase involved an evaluation of the impact of safety considerations involving redundant and/or backup systems on the selection of the regenerable life support subsystems. In addition, the impact of the space shuttle program on regenerable life support subsystem development was investigated.

Final postflight hardware evaluation report RSRM-32 (STS-57)

NASA Technical Reports Server (NTRS)

Nielson, Greg

1993-01-01

This document is the final report for the postflight assessment of the RSRM-32 (STS-57) flight set. This report presents the disassembly evaluations performed at the Thiokol facilities in Utah and is a continuation of the evaluations performed at KSC (TWR-64239). The PEEP for this assessment is outlined in TWR-50051, Revision B. The PEEP defines the requirements for evaluating RSRM hardware. Special hardware issues pertaining to this flight set requiring additional or modified assessment are outlined in TWR-64237. All observed hardware conditions were documented on PFOR's which are included in Appendix A. Observations were compared against limits defined in the PEEP. Any observation that was categorized as reportable or had no defined limits was documented on a preliminary PFAR by the assessment engineers. Preliminary PFAR's were reviewed by the Thiokol SPAT Executive Board to determine if elevation to PFAR's was required.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durham, M.D.

The purpose of this research program is to identify and evaluate a variety of additives capable of increasing particle cohesion which could be used for improving collection efficiency in an ESP. A three-phase screening process will be used to provide the, evaluation of many additives in a logical and cost-effective manner. The three step approach involves the following experimental setups: 1. Provide a preliminary screening in the laboratory by measuring the effects of various conditioning agents on reentrainment of flyash particles in an electric field operating at simulated flue gas conditions. 2. Evaluate the successful additives using a 100 acfmmore » bench-scale ESP operating on actual flue gas. 3. Obtain the data required for scaling up the technology by testing the two or three most promising conditioning agents at the pilot scale.« less

Flight test evaluation of the Stanford University/United Airlines differential GPS Category 3 automatic landing system

NASA Technical Reports Server (NTRS)

Kaufmann, David N.; Ncnally, B. David

1995-01-01

Test flights were conducted to evaluate the capability of Differential Global Positioning System (DGPS) to provide the accuracy and integrity required for International Civil Aviation Organization (ICAO) Category (CAT) 3 precision approach and landings. These test flights were part of a Federal Aviation Administration (FAA) program to evaluate the technical feasibility of using DGPS based technology for CAT 3 precision approach and landing applications. A United Airlines Boeing 737-300 (N304UA) was equipped with DGPS receiving equipment and additional computing capability provided by Stanford University. The test flights were conducted at NASA Ames Research Center's Crows Landing Flight Facility, Crows Landing, California. The flight test evaluation was based on completing 100 approaches and autolandings; 90 touch and go, and 10 terminating with a full stop. Two types of accuracy requirements were evaluated: 1) Total system error, based on the Required Navigation Performance (RNP), and 2) Navigation sensor error, based on ICAO requirements for the Microwave Landing System (MLS). All of the approaches and autolandings were evaluated against ground truth reference data provided by a laser tracker. Analysis of these approaches and autolandings shows that the Stanford University/United Airlines system met the requirements for a successful approach and autolanding 98 out of 100 approaches and autolandings, based on the total system error requirements as specified in the FAA CAT 3 Level 2 Flight Test Plan.

303 CD-ROMs To Use in Your Library: Descriptions, Evaluations, and Practical Advice.

ERIC Educational Resources Information Center

Dewey, Patrick R.

This book provides descriptions of approximately 270 CD-ROM packages and series, and references to dozens of others, all which are especially suitable for libraries. Organized by subject, entries include the vendor price (when available), platform and hardware requirements, and availability of network versions. In addition, evaluative comments…

Evaluation of High School Plus (HS+) in Montgomery County Public Schools

ERIC Educational Resources Information Center

Modarresi, Shahpar; Wade, Julie; Zhao, Huafang; Wolanin, Natalie

2014-01-01

The MCPS Office of Shared Accountability conducted an evaluation of the "High School Plus" (HS+) program implemented in Montgomery County (Maryland) Public Schools (MCPS). HS+ is one of the intervention programs offered by MCPS to provide additional ways of earning high school credits for students who have failed courses required for…

Evaluating a Web-Based Video Corpus through an Analysis of User Interactions

ERIC Educational Resources Information Center

Caws, Catherine G.

2013-01-01

As shown by several studies, successful integration of technology in language learning requires a holistic approach in order to scientifically understand what learners do when working with web-based technology (cf. Raby, 2007). Additionally, a growing body of research in computer assisted language learning (CALL) evaluation, design and…

78 FR 64541 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-29

... controverted. In addition, the requestor/petitioner shall provide a brief explanation of the bases for the... changes to the Bases or licensee-controlled document will be evaluated pursuant to the requirements of 10... isolation, or radiological consequences of any accident previously evaluated. Further, the proposed changes...

Field evaluation of ventilation system performance in enclosed parking garages

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ayari, A.M.; Grot, D.A.; Krarti, M.

2000-07-01

This paper summarizes the results of a field study to determine the ventilation requirements and the contaminant levels in existing enclosed parking garages. The testing was conducted in seven parking garages with different sizes, traffic flow patterns, vehicle types, and locations. In particular, the study compares the actual ventilation rates measured using the tracer gas technique with the ventilation requirements of ANSI/ASHRAE Standard 62-1989. In addition, the field test evaluated the effectiveness of the existing ventilation systems in maintaining acceptable contaminant levels within enclosed parking garages.

General Guidelines on Criteria for Adoption or Rejection of Evaluated Libraries and Data by the Nuclear Data Team

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neudecker, Denise; Conlin, Jeremy Lloyd; Gray, Mark Girard

This memo contains general guidelines on what documentation and tools need to be in place as well as format and data testing requirements such that evaluated nuclear data sets or entire libraries can be adopted by the nuclear data team. Additional requirements beyond this memo might apply for specific nuclear data observables. These guidelines were established based on discussions between J.L. Conlin, M.G. Gray, A.P. McCartney, D. Neudecker, D.K. Parsons and M.C. White.

Designing multifocal corneal models to correct presbyopia by laser ablation

NASA Astrophysics Data System (ADS)

Alarcón, Aixa; Anera, Rosario G.; Del Barco, Luis Jiménez; Jiménez, José R.

2012-01-01

Two multifocal corneal models and an aspheric model designed to correct presbyopia by corneal photoablation were evaluated. The design of each model was optimized to achieve the best visual quality possible for both near and distance vision. In addition, we evaluated the effect of myosis and pupil decentration on visual quality. The corrected model with the central zone for near vision provides better results since it requires less ablated corneal surface area, permits higher addition values, presents stabler visual quality with pupil-size variations and lower high-order aberrations.

The effect of high concentration additive on chiral separations in supercritical fluid chromatography.

PubMed

Speybrouck, David; Doublet, Charline; Cardinael, Pascal; Fiol-Petit, Catherine; Corens, David

2017-08-11

Supercritical Fluid Chromatography is frequently used to efficiently handle separations of enantiomers. The separation of basic analytes usually requires the addition of a basic additive in the mobile phase to improve the peak shape or even to elute the compounds. The effect of increasing the concentration of 2-propylamine as additive on the elution of a series of basic compounds on a Chiralpak-AD stationary phase was studied. In this study, unusual additive concentrations ranging from 0.3% to 10% of 2-propylamine 2-propylaminein the modifier were explored and the effect on retention, peak shape, selectivity and resolution was evaluated. The addition of a large quantity of additive allowed to drastically improve the selectivity and the resolution, and even enantiomers elution order reversal was observed by changing the concentration of basic additive. The role of the ratio additive/modifier appeared a key to tune the enantioselectivity. Finally, the impact of these drastic conditions on the column material was evaluated. Copyright © 2017 Elsevier B.V. All rights reserved.

75 FR 59935 - Investigational New Drug Safety Reporting Requirements for Human Drug and Biological Products and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... safety reporting for human drug products: Janet Norden, Center for Drug Evaluation and Research, Food and... for Biologics Evaluation and Research, Food and Drug Administration,1401 Rockville Pike, suite 200N..., 2003. At the request of industry, and to provide all interested persons additional time to comment, the...

76 FR 72498 - Rate for Use in Federal Debt Collection and Discount and Rebate Evaluation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-23

... evaluating the cost-effectiveness of a cash discount. In addition, 5 CFR 1315.8 of the Prompt Payment rule on... interest charges for outstanding debts owed to the Government. Treasury's Cash Management Requirements (TFM...: The rate reflects the current value of funds to the Treasury for use in connection with Federal Cash...

34 CFR 461.46 - What requirements for program reviews and evaluations must be met by a State?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 332(f)(7) of the Act. Note to § 461.46: In addition to the Adult Education State-administered Basic... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION... reviews and evaluations of all State-administered adult education programs, services, and activities it...

34 CFR 461.46 - What requirements for program reviews and evaluations must be met by a State?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 332(f)(7) of the Act. Note to § 461.46: In addition to the Adult Education State-administered Basic... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION... reviews and evaluations of all State-administered adult education programs, services, and activities it...

34 CFR 461.46 - What requirements for program reviews and evaluations must be met by a State?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 332(f)(7) of the Act. Note to § 461.46: In addition to the Adult Education State-administered Basic... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION... reviews and evaluations of all State-administered adult education programs, services, and activities it...

34 CFR 461.46 - What requirements for program reviews and evaluations must be met by a State?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 332(f)(7) of the Act. Note to § 461.46: In addition to the Adult Education State-administered Basic... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION... reviews and evaluations of all State-administered adult education programs, services, and activities it...

[Actual medical care situation and therapeutic needs in multiple sclerosis: Impact of the Pharmaceutical Market Restructuring Act (AMNOG)].

PubMed

Bittner, S; Meuth, S G

2016-04-01

The treatment of patients with multiple sclerosis (MS) is associated with constantly rising costs for the healthcare system and pharmaceuticals constitute 60 % of the direct medical costs. The Pharmaceutical Market Restructuring Act (Arzneimittelmarkt-Neuordnungsgesetz, AMNOG) came into force on 1 January 2011 with the aim of limiting the costs of pharmaceuticals by obligating newly approved products to be subjected to an early evaluation of the additional benefits by the Federal Joint Committee (FJC, Gemeinsamer Bundesausschuss, G‑BA). The majority of products evaluated up to October 2015 in neurology (5 out of 8) were approved for treatment of MS. Has the AMNOG been able to fulfill the original aims? Analysis of available information on MS therapies evaluated by the FJC between December 2010 and October 2015. For various reasons an additional benefit could be shown in only 2 out of 5 assessment procedures for MS drugs. It is obvious that some methodological shortcomings of the process have to be improved. Additionally requirements for pivotal clinical trials have to be harmonized with AMNOG requirements taking the best available evidence and real-life data into consideration (e.g. non-interventional studies) and a closer collaboration between the FJC, healthcare providers and the neurological societies is necessary. The AMNOG procedure currently only partially fulfills the original aims, which could be the reason why guidelines play a more important role for therapy decision-making than FJC decisions. As the early evaluation procedure is an adaptive process methodological shortcomings might be overcome in the future; however, this requires a much closer collaboration between the FJC and neurological societies.

Validation and verification of expert systems

NASA Technical Reports Server (NTRS)

Gilstrap, Lewey

1991-01-01

Validation and verification (V&V) are procedures used to evaluate system structure or behavior with respect to a set of requirements. Although expert systems are often developed as a series of prototypes without requirements, it is not possible to perform V&V on any system for which requirements have not been prepared. In addition, there are special problems associated with the evaluation of expert systems that do not arise in the evaluation of conventional systems, such as verification of the completeness and accuracy of the knowledge base. The criticality of most NASA missions make it important to be able to certify the performance of the expert systems used to support these mission. Recommendations for the most appropriate method for integrating V&V into the Expert System Development Methodology (ESDM) and suggestions for the most suitable approaches for each stage of ESDM development are presented.

Flue gas conditioning for improved particle collection in electrostatic precipitators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durham, M.D.

1992-04-27

The purpose of this research program is to identify and evaluate a variety of additives capable of increasing particle cohesion which could be used for improving collection efficiency in an ESP. A three-phase screening process will be used to provide the, evaluation of many additives in a logical and cost-effective manner. The three step approach involves the following experimental setups: 1. Provide a preliminary screening in the laboratory by measuring the effects of various conditioning agents on reentrainment of flyash particles in an electric field operating at simulated flue gas conditions. 2. Evaluate the successful additives using a 100 acfmmore » bench-scale ESP operating on actual flue gas. 3. Obtain the data required for scaling up the technology by testing the two or three most promising conditioning agents at the pilot scale.« less

Evaluation of DUII Sentencing Practices in Oregon.

DOT National Transportation Integrated Search

1997-10-01

Oregon law requires motorists driving under the influence of intoxicants (DUII) to be sentenced with some sanctions, and allows judges the use of additional sanctions. Sanctions including drug/alcohol treatment, jail time, community service, etc., ar...

Using a Balance Scorecard Approach to Evaluate the Value of Service Learning Projects in Online Courses

ERIC Educational Resources Information Center

Schwieger, Dana

2015-01-01

Service learning projects serve as a valuable tool for applying course concepts in a way to benefit both the students and community. However, they often require a significant amount of additional effort beyond that required of assigning conventional homework problems. When the projects take place in an online course setting, the level of…

Visual soil evaluation - future research requirements

NASA Astrophysics Data System (ADS)

Emmet-Booth, Jeremy; Forristal, Dermot; Fenton, Owen; Ball, Bruce; Holden, Nick

2017-04-01

A review of Visual Soil Evaluation (VSE) techniques (Emmet-Booth et al., 2016) highlighted their established utility for soil quality assessment, though some limitations were identified; (1) The examination of aggregate size, visible intra-porosity and shape forms a key assessment criterion in almost all methods, thus limiting evaluation to structural form. The addition of criteria that holistically examine structure may be desirable. For example, structural stability can be indicated using dispersion tests or examining soil surface crusting, while the assessment of soil colour may indirectly indicate soil organic matter content, a contributor to stability. Organic matter assessment may also indicate structural resilience, along with rooting, earthworm numbers or shrinkage cracking. (2) Soil texture may influence results or impeded method deployment. Modification of procedures to account for extreme texture variation is desirable. For example, evidence of compaction in sandy or single grain soils greatly differs to that in clayey soils. Some procedures incorporate separate classification systems or adjust deployment based on texture. (3) Research into impacts of soil moisture content on VSE evaluation criteria is required. Criteria such as rupture resistance and shape may be affected by moisture content. It is generally recommended that methods are deployed on moist soils and quantification of influences of moisture variation on results is necessary. (4) Robust sampling strategies for method deployment are required. Dealing with spatial variation differs between methods, but where methods can be deployed over large areas, clear instruction on sampling is required. Additionally, as emphasis has been placed on the agricultural production of soil, so the ability of VSE for exploring structural quality in terms of carbon storage, water purification and biodiversity support also requires research. References Emmet-Booth, J.P., Forristal. P.D., Fenton, O., Ball, B.C. & Holden, N.M. 2016. A review of visual soil evaluation techniques for soil structure. Soil Use and Management, 32, 623-634.

Tier One Performance Screen Initial Operational Test and Evaluation: 2010 Annual Report

DTIC Science & Technology

2011-10-01

ANNUAL REPORT EXECUTIVE SUMMARY Research Requirement: In addition to educational, physical , and moral screens, the U.S. Army relies on a...number of criteria of interest. Most notably, the Physical Conditioning scale predicted Soldiers’ self- reported Army Physical Fitness Test (APFT...individual Soldier through maximally effective selection, classification, and retention strategies. In addition to educational, physical , and moral

Learning from internships in gerontology and geriatrics: assessment and program evaluation.

PubMed

Karasik, Rona J

2009-01-01

Internships are an essential component of gerontological education. Harvesting the learning from internships, however, requires careful attention to assessing an intern's work. In addition to providing feedback to students, internship assessment can also yield data useful for academic program evaluation. Drawing on internship assessment data collected from undergraduate and graduate gerontology interns and their community preceptors over a period of seven semesters, this article explores (1) concerns regarding how to assess what interns are learning, (2) ways to provide students with additional opportunities for learning from their internships, and (3) how information from these student-learning outcomes may be used to evaluate the effectiveness of the overall academic program.

Evaluation of offspring and maternal genetic effects on disease risk using a family-based approach: the "pent" design.

PubMed

Mitchell, Laura E; Weinberg, Clarice R

2005-10-01

Diseases that develop during gestation may be influenced by the genotype of the mother and the inherited genotype of the embryo/fetus. However, given the correlation between maternal and offspring genotypes, differentiating between inherited and maternal genetic effects is not straightforward. The two-step transmission disequilibrium test was the first, family-based test proposed for the purpose of differentiating between maternal and offspring genetic effects. However, this approach, which requires data from "pents" comprising an affected child, mother, father, and maternal grandparents, provides biased tests for maternal genetic effects when the offspring genotype is associated with disease. An alternative approach based on transmissions from grandparents provides unbiased tests for maternal and offspring genetic effects but requires genotype information for paternal grandparents in addition to pents. The authors have developed two additional, pent-based approaches for the evaluation of maternal and offspring genetic effects. One approach requires the assumption of genetic mating type symmetry (pent-1), whereas the other does not (pent-2). Simulation studies demonstrate that both of these approaches provide valid estimation and testing for offspring and maternal genotypic effects. In addition, the power of the pent-1 approach is comparable with that of the approach based on data using all four grandparents.

Field validation of protocols developed to evaluate in-line mastitis detection systems.

PubMed

Kamphuis, C; Dela Rue, B T; Eastwood, C R

2016-02-01

This paper reports on a field validation of previously developed protocols for evaluating the performance of in-line mastitis-detection systems. The protocols outlined 2 requirements of these systems: (1) to detect cows with clinical mastitis (CM) promptly and accurately to enable timely and appropriate treatment and (2) to identify cows with high somatic cell count (SCC) to manage bulk milk SCC levels. Gold standard measures, evaluation tests, performance measures, and performance targets were proposed. The current study validated the protocols on commercial dairy farms with automated in-line mastitis-detection systems using both electrical conductivity (EC) and SCC sensor systems that both monitor at whole-udder level. The protocol for requirement 1 was applied on 3 commercial farms. For requirement 2, the protocol was applied on 6 farms; 3 of them had low bulk milk SCC (128×10(3) cells/mL) and were the same farms as used for field evaluation of requirement 1. Three farms with high bulk milk SCC (270×10(3) cells/mL) were additionally enrolled. The field evaluation methodology and results were presented at a workshop including representation from 7 international suppliers of in-line mastitis-detection systems. Feedback was sought on the acceptance of standardized performance evaluation protocols and recommended refinements to the protocols. Although the methodology for requirement 1 was relatively labor intensive and required organizational skills over an extended period, no major issues were encountered during the field validation of both protocols. The validation, thus, proved the protocols to be practical. Also, no changes to the data collection process were recommended by the technology supplier representatives. However, 4 recommendations were made to refine the protocols: inclusion of an additional analysis that ignores small (low-density) clot observations in the definition of CM, extension of the time window from 4 to 5 milkings for timely alerts for CM, setting a maximum number of 10 milkings for the time window to detect a CM episode, and presentation of sensitivity for a larger range of false alerts per 1,000 milkings replacing minimum performance targets. The recommended refinements are discussed with suggested changes to the original protocols. The information presented is intended to inform further debate toward achieving international agreement on standard protocols to evaluate performance of in-line mastitis-detection systems. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

High-density fuel effects. Final report, September 1985-April 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rizk, N.K.; Oechsie, V.L.; Ross, P.T.

1988-08-18

The purpose of this program was to determine, by combustor rig tests and data evaluation, the effects of the high-density fuel properties on the performance and durability of the Allison T56-A-15 combustion system. Four high-density fuels in addition to baseline JP4 were evaluated in the effort. The rig-test program included: nozzle-flow bench testing, aerothermal performance and wall temperature, flame stability and ignition, injector coking and plugging, and flow-transient effect. The data-evaluation effort involved the utilization of empirical correlations in addition to analytical multidimensional tools to analyze the performance of the combustor. The modifications required to optimize the performance with high-densitymore » fuels were suggested and the expected improvement in performance was evaluated.« less

The implementation of multiple interprofessional integrated modules by health sciences faculty in Chile.

PubMed

Castillo-Parra, Silvana; Oyarzo Torres, Sandra; Espinoza Barrios, Mónica; Rojas-Serey, Ana María; Maya, Juan Diego; Sabaj Diez, Valeria; Aliaga Castillo, Verónica; Castillo Niño, Manuel; Romero Romero, Luis; Foster, Jennifer; Hawes Barrios, Gustavo

2017-11-01

Multiple interprofessional integrated modules (MIIM) 1 and 2 are two required, cross-curricular courses developed by a team of health professions faculty, as well as experts in education, within the Faculty of Medicine of the University of Chile. MIIM 1 focused on virtual cases requiring team decision-making in real time. MIIM 2 focused on a team-based community project. The evaluation of MIIM included student, teacher, and coordinator perspectives. To explore the perceptions of this interprofessional experience quantitative data in the form of standardised course evaluations regarding teaching methodology, interpersonal relations and the course organisation and logistics were gathered. In addition, qualitative perceptions were collected from student focus groups and meetings with tutors and coordinators. Between 2010 and 2014, 881 students enrolled in MIIM. Their evaluation scores rated interpersonal relations most highly, followed by organisation and logistics, and then teaching methodology. A key result was the learning related to interprofessional team work by the teaching coordinators, as well as the participating faculty. The strengths of this experience included student integration and construction of new knowledge, skill development in making decisions, and collective self-learning. Challenges included additional time management and tutors' role. This work requires valuation of an alternative way of learning, which is critical for the performance of future health professionals.

10 CFR 54.37 - Additional records and recordkeeping requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... identified that would have been subject to an aging management review or evaluation of time-limited aging analyses in accordance with § 54.21. This FSAR update must describe how the effects of aging will be...

10 CFR 54.37 - Additional records and recordkeeping requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... identified that would have been subject to an aging management review or evaluation of time-limited aging analyses in accordance with § 54.21. This FSAR update must describe how the effects of aging will be...

10 CFR 54.37 - Additional records and recordkeeping requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... identified that would have been subject to an aging management review or evaluation of time-limited aging analyses in accordance with § 54.21. This FSAR update must describe how the effects of aging will be...

10 CFR 54.37 - Additional records and recordkeeping requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... identified that would have been subject to an aging management review or evaluation of time-limited aging analyses in accordance with § 54.21. This FSAR update must describe how the effects of aging will be...

10 CFR 54.37 - Additional records and recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... identified that would have been subject to an aging management review or evaluation of time-limited aging analyses in accordance with § 54.21. This FSAR update must describe how the effects of aging will be...

Archived Data User Service self evaluation report : FAST

DOT National Transportation Integrated Search

2000-11-01

The Archived Data User Service (ADUS) is a recent addition to the National Intelligent Transportation System (ITS) Architecture. This user service required ITS system to have the capability to receive, collect and archive ITS-generated operational...

Evaluation of water-quality data and monitoring program for Lake Travis, near Austin, Texas

USGS Publications Warehouse

Rast, Walter; Slade, Raymond M.

1998-01-01

The multiple-comparison tests indicate that, for some constituents, a single sampling site for a constituent or property might adequately characterize the water quality of Lake Travis for that constituent or property. However, multiple sampling sites are required to provide information of sufficient temporal and spatial resolution to accurately evaluate other water-quality constituents for the reservoir. For example, the water-quality data from surface samples and from bottom samples indicate that nutrients (nitrogen, phosphorus) might require additional sampling sites for a more accurate characterization of their in-lake dynamics.

Technology Insertion for Recapitalization of Legacy Systems

DTIC Science & Technology

2015-09-30

peened, and 4) an Abcite coating will be flame sprayed on the component. The ALCM program (B) has 1) evaluated data provided, 2) gathered questions...Report Technology Insertion for the Recapitalization of Legacy Systems Laser sintering, thermal spray and cold spray are additive manufacturing methods... coatings Need an experienced operator Requires a special spray booth to limit overspray and protect operator Requires primer or surface treatment

Metrology: Calibration and measurement processes guidelines

NASA Technical Reports Server (NTRS)

Castrup, Howard T.; Eicke, Woodward G.; Hayes, Jerry L.; Mark, Alexander; Martin, Robert E.; Taylor, James L.

1994-01-01

The guide is intended as a resource to aid engineers and systems contracts in the design, implementation, and operation of metrology, calibration, and measurement systems, and to assist NASA personnel in the uniform evaluation of such systems supplied or operated by contractors. Methodologies and techniques acceptable in fulfilling metrology quality requirements for NASA programs are outlined. The measurement process is covered from a high level through more detailed discussions of key elements within the process, Emphasis is given to the flowdown of project requirements to measurement system requirements, then through the activities that will provide measurements with defined quality. In addition, innovations and techniques for error analysis, development of statistical measurement process control, optimization of calibration recall systems, and evaluation of measurement uncertainty are presented.

Capturing security requirements for software systems.

PubMed

El-Hadary, Hassan; El-Kassas, Sherif

2014-07-01

Security is often an afterthought during software development. Realizing security early, especially in the requirement phase, is important so that security problems can be tackled early enough before going further in the process and avoid rework. A more effective approach for security requirement engineering is needed to provide a more systematic way for eliciting adequate security requirements. This paper proposes a methodology for security requirement elicitation based on problem frames. The methodology aims at early integration of security with software development. The main goal of the methodology is to assist developers elicit adequate security requirements in a more systematic way during the requirement engineering process. A security catalog, based on the problem frames, is constructed in order to help identifying security requirements with the aid of previous security knowledge. Abuse frames are used to model threats while security problem frames are used to model security requirements. We have made use of evaluation criteria to evaluate the resulting security requirements concentrating on conflicts identification among requirements. We have shown that more complete security requirements can be elicited by such methodology in addition to the assistance offered to developers to elicit security requirements in a more systematic way.

Capturing security requirements for software systems

PubMed Central

El-Hadary, Hassan; El-Kassas, Sherif

2014-01-01

Security is often an afterthought during software development. Realizing security early, especially in the requirement phase, is important so that security problems can be tackled early enough before going further in the process and avoid rework. A more effective approach for security requirement engineering is needed to provide a more systematic way for eliciting adequate security requirements. This paper proposes a methodology for security requirement elicitation based on problem frames. The methodology aims at early integration of security with software development. The main goal of the methodology is to assist developers elicit adequate security requirements in a more systematic way during the requirement engineering process. A security catalog, based on the problem frames, is constructed in order to help identifying security requirements with the aid of previous security knowledge. Abuse frames are used to model threats while security problem frames are used to model security requirements. We have made use of evaluation criteria to evaluate the resulting security requirements concentrating on conflicts identification among requirements. We have shown that more complete security requirements can be elicited by such methodology in addition to the assistance offered to developers to elicit security requirements in a more systematic way. PMID:25685514

Connecticut Department of Transportation safety techniques enhancement plan.

DOT National Transportation Integrated Search

2015-03-15

The Highway Safety Manual (HSM) defines a six-step cycle of safety management processes. This report evaluates the : Conncituct Department on how well conform to the six safety management steps. The methods recommended in the HSM : require additional...

Treatment of the Cornea Using Transcytotic Delivery into the Tear Film

DTIC Science & Technology

2015-12-01

early April 2013; however, we continue to produce additional material as required (Fig. 4). In milestone 3 we initiated in vivo evaluation of...SI, the minimum and maximum values are 12.4 and 34.4. 8 Aim 2) characterize Lacritin-ELP fusion proteins and evaluate as therapeutic agents...0.0001). Data were analyzed by a two-way ANOVA followed by Tukey’s multiple comparisons test (n=9). 10 Having evaluated the lacritin-ELP fusion in

A Geometric Analysis to Protect Manned Assets from Newly Launched Objects - Cola Gap Analysis

NASA Technical Reports Server (NTRS)

Hametz, Mark E.; Beaver, Brian A.

2013-01-01

A safety risk was identified for the International Space Station (ISS) by The Aerospace Corporation, where the ISS would be unable to react to a conjunction with a newly launched object following the end of the launch Collision Avoidance (COLA) process. Once an object is launched, there is a finite period of time required to track, catalog, and evaluate that new object as part of standard onorbit COLA screening processes. Additionally, should a conjunction be identified, there is an additional period of time required to plan and execute a collision avoidance maneuver. While the computed prelaunch probability of collision with any object is extremely low, NASA/JSC has requested that all US launches take additional steps to protect the ISS during this "COLA gap" period. This paper details a geometric-based COLA gap analysis method developed by the NASA Launch Services Program to determine if launch window cutouts are required to mitigate this risk. Additionally, this paper presents the results of several missions where this process has been used operationally.

The use of AntiMisting Kerosene (AMK) in turbojet engines

NASA Technical Reports Server (NTRS)

Schmidt, H. W.

1981-01-01

The effect of antimisting kerosene (AMK) flow characteristics on fan jet engines and the impact of degradation requirements on the fuel system was evaluated. It was determined from the present program that AMK fuel cannot be used without predegradation, although some degradation occurs throughout the fuel feed system, expecially in the fuel pumps. There is a tendency toward FM-9 AMK additive agglomeration and gel formation when the liquid flows at a critical velocity through very small passages. The data indicate this phenomenon to be a function of the degree of degradation, the passage size, the differential pressure, the fluid temperature, and the accumulated flow time. Additionally, test results indicate that the long term cumulative effects of this phenomenon may require more degradation than the theoretical requirement determined from short term tests.

Tier One Performance Screen Initial Operational Test and Evaluation: 2011 Annual Report

DTIC Science & Technology

2013-01-01

OPERATIONAL TEST AND EVALUATION: 2011 ANNUAL REPORT EXECUTIVE SUMMARY Research Requirement: In addition to educational, physical , and...34 Table 5.4. Incremental Validity Estimates for the TAPAS and TOPS Composite Scales over the AFQT for Predicting IMT Physical Fitness Criteria by...Validity Estimates for the TAPAS and TOPS Composite Scales over the AFQT for Predicting In-Unit Physical Fitness Criteria by Education Tier

STS ancillary equipment study. User reference book

NASA Technical Reports Server (NTRS)

Plough, J. A.

1977-01-01

A record of what is currently known about STS ancillary equipment is presented in this user-oriented design so that a potential user may evaluate whether he could use the described ancillary equipment or if he would need to design and fabricate a payload-unique item. References that the user can use to obtain additional details and requirements to aid in his evaluation and decision are included.

Progress on the upgrade of the CMS Hadron Calorimeter Front-End electronics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, Jake; Whitmore, Juliana; /Fermilab

2011-11-01

We present a scheme to upgrade the CMS HCAL front-end electronics in the second long shutdown to upgrade the LHC (LS2), which is expected to occur around 2018. The HCAL electronics upgrade is required to handle the major instantaneous luminosity increase (up to 5 * 10{sup 34} cm{sup -2} s{sup -1}) and an expected integrated luminosity of {approx}3000 fb{sup -1}. A key aspect of the HCAL upgrade is to read out longitudinal segmentation information to improve background rejection, energy resolution, and electron isolation at the L1 trigger. This paper focuses on the requirements for the new electronics and on themore » proposed solutions. The requirements include increased channel count, additional timing capabilities, and additional redundancy. The electronics are required to operate in a harsh environment and are constrained by the existing infrastructure. The proposed solutions span from chip level to system level. They include the development of a new ASIC ADC, the design and testing of higher speed transmitters to handle the increased data volume, the evaluation and use of circuits from other developments, evaluation of commercial FPGAs, better thermal design, and improvements in the overall readout architecture. We will report on the progress of the designs for these upgraded systems, along with performance requirements and initial design studies.« less

Twelve tips for blueprinting.

PubMed

Coderre, Sylvain; Woloschuk, Wayne; McLaughlin, Kevin

2009-04-01

Content validity is a requirement of every evaluation and is achieved when the evaluation content is congruent with the learning objectives and the learning experiences. Congruence between these three pillars of education can be facilitated by blueprinting. Here we describe an efficient process for creating a blueprint and explain how to use this tool to guide all aspects of course creation and evaluation. A well constructed blueprint is a valuable tool for medical educators. In addition to validating evaluation content, a blueprint can also be used to guide selection of curricular content and learning experiences.

Characterization of asphalt cements modified with crumbed rubber from discarded tires : final report.

DOT National Transportation Integrated Search

1994-11-01

The potential legislative requirement for incorporation of scrap rubber into asphalt blends mandated a thorough evaluation of the influence of scrap rubber additives on the physical properties and aging characteristics of rubber/asphalt blends. Blend...

Maintenance energy requirements of odor detection, explosive detection and human detection working dogs.

PubMed

Mullis, Rebecca A; Witzel, Angela L; Price, Joshua

2015-01-01

Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing. This study is the first to evaluate the energy requirements of working dogs trained in odor, explosive and human detection. This retrospective study evaluated twenty adult dogs who maintained consistent body weights over a six month period. During this time, the average energy consumption was [Formula: see text] or two times the calculated resting energy requirement ([Formula: see text]). No statistical differences were found between breeds, age or sex, but a statistically significant association (p = 0.0033, R-square = 0.0854) was seen between the number of searches a dog performs and their energy requirement. Based on this study's population, it appears that working dogs have maintenance energy requirements similar to the 1974 National Research Council's (NRC) maintenance energy requirement of [Formula: see text] (National Research Council (NRC), 1974) and the [Formula: see text] reported for young laboratory beagles (Rainbird & Kienzle, 1990). Additional research is needed to determine if these data can be applied to all odor, explosive and human detection dogs and to determine if other types of working dogs (tracking, search and rescue etc.) have similar energy requirements.

Integrated Autopilot/Autothrottle Based on a Total Energy Control Concept: Design and Evaluation of Additional Autopilot Modes

NASA Technical Reports Server (NTRS)

Bruce, Kevin R.

1988-01-01

An integrated autopilot/autothrottle system was designed using a total energy control design philosophy. This design ensures that the system can differentiate between maneuvers requiring a change in thrust to accomplish a net energy change, and those maneuvers which only require elevator control to redistribute energy. The system design, the development of the system, and a summary of simulation results are defined.

Bariatric surgery insurance requirements independently predict surgery dropout.

PubMed

Love, Kaitlin M; Mehaffey, J Hunter; Safavian, Dana; Schirmer, Bruce; Malin, Steven K; Hallowell, Peter T; Kirby, Jennifer L

2017-05-01

Many insurance companies have considerable prebariatric surgery requirements despite a lack of evidence for improved clinical outcomes. The hypothesis of this study is that insurance-specific requirements will be associated with a decreased progression to surgery and increased delay in time to surgery. Retrospective data collection was performed for patients undergoing bariatric surgery evaluation from 2010-2015. Patients who underwent surgery (SGY; n = 827; mean body mass index [BMI] 49.1) were compared with those who did not (no-SGY; n = 648; mean BMI: 49.4). Univariate and multivariate analysis were performed to identify specific co-morbidity and insurance specific predictors of surgical dropout and time to surgery. A total of 1475 patients using 12 major insurance payors were included. Univariate analysis found insurance requirements associated with surgical drop out included longer median diet duration (no-SGY = 6 mo; SGY = 3 mo; P<.001); primary care physician letter of necessity (P<.0001); laboratory testing (P = .019); and evaluation by cardiology (P<.001), pulmonology (P<.0001), or psychiatry (P = .0003). Using logistic regression to control for co-morbidities, longer diet requirement (odds ratio [OR] .88, P<.0001), primary care physician letter (OR .33, P<.0001), cardiology evaluation (OR .22, P = .038), and advanced laboratory testing (OR 5.75, P = .019) independently predicted surgery dropout. Additionally, surgical patients had an average interval between initial visit and surgery of 5.8±4.6 months with significant weight gain (2.1 kg, P<.0001). Many prebariatric surgery insurance requirements were associated with lack of patient progression to surgery in this study. In addition, delays in surgery were associated with preoperative weight gain. Although prospective and multicenter studies are needed, these findings have major policy implications suggesting insurance requirements may need to be reconsidered to improve medical care. Copyright © 2017 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

Minimum Hamiltonian Ascent Trajectory Evaluation (MASTRE) program (update to automatic flight trajectory design, performance prediction, and vehicle sizing for support of Shuttle and Shuttle derived vehicles) engineering manual

NASA Technical Reports Server (NTRS)

Lyons, J. T.

1993-01-01

The Minimum Hamiltonian Ascent Trajectory Evaluation (MASTRE) program and its predecessors, the ROBOT and the RAGMOP programs, have had a long history of supporting MSFC in the simulation of space boosters for the purpose of performance evaluation. The ROBOT program was used in the simulation of the Saturn 1B and Saturn 5 vehicles in the 1960's and provided the first utilization of the minimum Hamiltonian (or min-H) methodology and the steepest ascent technique to solve the optimum trajectory problem. The advent of the Space Shuttle in the 1970's and its complex airplane design required a redesign of the trajectory simulation code since aerodynamic flight and controllability were required for proper simulation. The RAGMOP program was the first attempt to incorporate the complex equations of the Space Shuttle into an optimization tool by using an optimization method based on steepest ascent techniques (but without the min-H methodology). Development of the complex partial derivatives associated with the Space Shuttle configuration and using techniques from the RAGMOP program, the ROBOT program was redesigned to incorporate these additional complexities. This redesign created the MASTRE program, which was referred to as the Minimum Hamiltonian Ascent Shuttle TRajectory Evaluation program at that time. Unique to this program were first-stage (or booster) nonlinear aerodynamics, upper-stage linear aerodynamics, engine control via moment balance, liquid and solid thrust forces, variable liquid throttling to maintain constant acceleration limits, and a total upgrade of the equations used in the forward and backward integration segments of the program. This modification of the MASTRE code has been used to simulate the new space vehicles associated with the National Launch Systems (NLS). Although not as complicated as the Space Shuttle, the simulation and analysis of the NLS vehicles required additional modifications to the MASTRE program in the areas of providing additional flexibility in the use of the program, allowing additional optimization options, and providing special options for the NLS configuration.

Summary Report of Laboratory Testing to Establish the Effectiveness of Proposed Treatment Methods for Unremediated and Remediated Nitrate Salt Waste Streams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anast, Kurt Roy; Funk, David John

The inadvertent creation of transuranic waste carrying hazardous waste codes D001 and D002 requires the treatment of the material to eliminate the hazardous characteristics and allow its eventual shipment and disposal at the Waste Isolation Pilot Plant (WIPP). This report documents the effectiveness of two treatment methods proposed to stabilize both the unremediated and remediated nitrate salt waste streams (UNS and RNS, respectively). The two technologies include the addition of zeolite (with and without the addition of water as a processing aid) and cementation. Surrogates were developed to evaluate both the solid and liquid fractions expected from parent waste containers,more » and both the solid and liquid fractions were tested. Both technologies are shown to be effective at eliminating the characteristic of ignitability (D001), and the addition of zeolite was determined to be effective at eliminating corrosivity (D002), with the preferred option1 of zeolite addition currently planned for implementation at the Waste Characterization, Reduction, and Repackaging Facility. During the course of this work, we established the need to evaluate and demonstrate the effectiveness of the proposed remedy for debris material, if required. The evaluation determined that Wypalls absorbed with saturated nitrate salt solutions exhibit the ignitability characteristic (all other expected debris is not classified as ignitable). Follow-on studies will be developed to demonstrate the effectiveness of stabilization for ignitable Wypall debris. Finally, liquid surrogates containing saturated nitrate salts did not exhibit the characteristic of ignitability in their pure form (those neutralized with Kolorsafe and mixed with sWheat did exhibit D001). As a result, additional nitrate salt solutions (those exhibiting the oxidizer characteristic) will be tested to demonstrate the effectiveness of the remedy.« less

Attrition in longitudinal randomized controlled trials: home visits make a difference.

PubMed

Peterson, Janey C; Pirraglia, Paul A; Wells, Martin T; Charlson, Mary E

2012-11-23

Participant attrition in longitudinal studies can introduce systematic bias, favoring participants who return for follow-up, and increase the likelihood that those with complications will be underestimated. Our aim was to examine the effectiveness of home follow-up (Home F/U) to complete the final study evaluation on potentially "lost" participants by: 1) evaluating the impact of including and excluding potentially "lost" participants (e.g., those who required Home F/U to complete the final evaluation) on the rates of study complications; 2) examining the relationship between timing and number of complications on the requirement for subsequent Home F/U; and 3) determining predictors of those who required Home F/U. We used data from a randomized controlled trial (RCT) conducted from 1991-1994 among coronary artery bypass graft surgery patients that investigated the effect of High mean arterial pressure (MAP) (intervention) vs. Low MAP (control) during cardiopulmonary bypass on 5 complications: cardiac morbidity/mortality, neurologic morbidity/mortality, all-cause mortality, neurocognitive dysfunction and functional decline. We enhanced completion of the final 6-month evaluation using Home F/U. Among 248 participants, 61 (25%) required Home F/U and the remaining 187 (75%) received Routine F/U. By employing Home F/U, we detected 11 additional complications at 6 months: 1 major neurologic complication, 6 cases of neurocognitive dysfunction and 4 cases of functional decline. Follow-up of 61 additional Home F/U participants enabled us to reach statistical significance on our main trial outcome. Specifically, the High MAP group had a significantly lower rate of the Combined Trial Outcome compared to the Low MAP group, 16.1% vs. 27.4% (p=0.032). In multivariate analysis, participants who were ≥ 75 years (OR=3.23, 95% CI 1.52-6.88, p=0.002) or on baseline diuretic therapy (OR=2.44, 95% CI 1.14-5.21, p=0.02) were more likely to require Home F/U. In addition, those in the Home F/U group were more likely to have sustained 2 or more complications (p=0.05). Home visits are an effective approach to reduce attrition and improve accuracy of study outcome reporting. Trial results may be influenced by this method of reducing attrition. Older participants, those with greater medical burden and those who sustain multiple complications are at higher risk for attrition.

Standardized technique for single-incision laparoscopic-assisted stoma creation.

PubMed

Miyoshi, Norikatsu; Fujino, Shiki; Ohue, Masayuki; Yasui, Masayoshi; Noura, Shingo; Wada, Yuma; Kimura, Ryuichiro; Sugimura, Keijiro; Tomokuni, Akira; Akita, Hirofumi; Kobayashi, Shogo; Takahashi, Hidenori; Omori, Takeshi; Fujiwara, Yoshiyuki; Yano, Masahiko

2016-08-10

To describe the procedure, efficacy, and utility of single-incision laparoscopic-assisted stoma creation (SILStoma) for transverse colostomy. Using single-incision laparoscopic surgery, we developed a standardized technique for SILStoma. Twelve consecutive patients underwent SILStoma for transverse colostomy at Osaka Medical Center for Cancer and Cardiovascular Diseases from April 2013 to March 2016. A single, intended stoma site was created with a 2.5-3.5 cm skin incision for primary access to the intra-abdominal space, and it functioned as the main port through which multi-trocars were placed. Clinical and operative factors and postoperative outcomes were evaluated. Patient demographics, including age, gender, body mass index, and surgical indications for intestinal diversion were evaluated. SILStoma was performed in nine cases without the requirement of additional ports. In the remaining three cases, 1-2 additional 5-mm ports were required for mobilization of the transverse colon and safe dissection of abdominal adhesions. No cases required conversion to open surgery. In all cases, SILStoma was completed at the initial stoma site marked preoperatively. No intraoperative or postoperative complications greater than Grade II (the Clavien-Dindo classification) were reported in the complication survey. Surgical site infection at stoma sites was observed in four cases; however, surgical interventions were not required and all infections were cured completely. In all cases, the resumption of bowel movements was observed between postoperative days 1 and 2. SILStoma for transverse loop colostomy represents a feasible surgical procedure that allows the creation of a stoma at the preoperatively marked site without any additional large skin incisions.

76 FR 29335 - Qualification, Service, and Use of Crewmembers and Aircraft Dispatchers

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

...On January 12, 2009, the FAA published a notice of proposed rulemaking on qualification, service, and use of crewmembers and aircraft dispatchers. Because of the complexity of the issues and the concerns raised by commenters, the FAA is issuing this supplemental notice of proposed rulemaking. The FAA proposes to amend the regulations for crewmember and aircraft dispatcher training programs in domestic, flag, and supplemental operations. The proposed regulations enhance traditional training programs by requiring the use of flight simulation training devices for flightcrew members and including additional training and evaluation requirements for all crewmembers and aircraft dispatchers in areas that are critical to safety. The proposal also reorganizes and revises the qualification, training, and evaluation requirements. The proposed changes are intended to contribute significantly to reducing aviation accidents.

Los Angeles congestion reduction demonstration (Metro ExpressLanes) program. National evaluation : exogenous factors test plan.

DOT National Transportation Integrated Search

1999-12-01

The Traceability document consists of brief introductory material and a series of appended Trace Tables. These tables provide complete traceability of ITS User Service Requirements (USR) to elements of the National ITS Architecture. Additional Trace ...

Economic comparison of conventional maintenance and electrochemical oxidation to warrant water safety in dental unit water lines.

PubMed

Fischer, Sebastian; Meyer, Georg; Kramer, Axel

2012-01-01

In preparation for implementation of a central water processing system at a dental department, we analyzed the costs of conventional decentralized disinfection of dental units against a central water treatment concept based on electrochemical disinfection. The cost evaluation included only the costs of annually required antimicrobial consumables and additional water usage of a decentralize conventional maintenance system for dental water lines build in the respective dental units and the central electrochemical water disinfection system, BLUE SAFETY™ Technologies. In total, analysis of costs of 6 dental departments reviled additional annual costs for hygienic preventive measures of € 4,448.37. For the BLUE SAFETY™ Technology, the additional annual total agent consumption costs were € 2.18, accounting for approximately 0.05% of the annual total agent consumption costs of the conventional maintenance system. For both water processing concepts, the additional costs for energy could not be calculated, since the required data was not obtainable from the manufacturers. For both concepts, the investment and maintenance costs were not calculated due to lack of manufacturer's data. Therefore, the results indicate the difference of costs for the required consumables only. Aside of the significantly lower annual costs for required consumables and disinfectants; a second advantage for the BLUE SAFETY™ Technology is its constant and automatic operation, which does not require additional staff resources. This not only safety human resources, but add additionally to cost saving. Since the antimicrobial disinfection capacity of the BLUE SAFETY™ was demonstrated previously and is well known, this technology, which is comparable or even superior in its non-corrosive effect, may be regarded as method of choice for continuous disinfection and prevention of biofilm formation in dental units' water lines.

Economic comparison of conventional maintenance and electrochemical oxidation to warrant water safety in dental unit water lines

PubMed Central

Fischer, Sebastian; Meyer, Georg; Kramer, Axel

2012-01-01

Background: In preparation for implementation of a central water processing system at a dental department, we analyzed the costs of conventional decentralized disinfection of dental units against a central water treatment concept based on electrochemical disinfection. Methods: The cost evaluation included only the costs of annually required antimicrobial consumables and additional water usage of a decentralize conventional maintenance system for dental water lines build in the respective dental units and the central electrochemical water disinfection system, BLUE SAFETY™ Technologies. Results: In total, analysis of costs of 6 dental departments reviled additional annual costs for hygienic preventive measures of € 4,448.37. For the BLUE SAFETY™ Technology, the additional annual total agent consumption costs were € 2.18, accounting for approximately 0.05% of the annual total agent consumption costs of the conventional maintenance system. For both water processing concepts, the additional costs for energy could not be calculated, since the required data was not obtainable from the manufacturers. Discussion: For both concepts, the investment and maintenance costs were not calculated due to lack of manufacturer's data. Therefore, the results indicate the difference of costs for the required consumables only. Aside of the significantly lower annual costs for required consumables and disinfectants; a second advantage for the BLUE SAFETY™ Technology is its constant and automatic operation, which does not require additional staff resources. This not only safety human resources, but add additionally to cost saving. Conclusion: Since the antimicrobial disinfection capacity of the BLUE SAFETY™ was demonstrated previously and is well known, this technology, which is comparable or even superior in its non-corrosive effect, may be regarded as method of choice for continuous disinfection and prevention of biofilm formation in dental units’ water lines. PMID:22558042

Proposed Bak Stabilization Tennessee River, River Mile 466.2 - 466.5 Hamilton County, Tennessee

DTIC Science & Technology

2013-04-01

Project Planning Branch EA Preparation Mitzy Schaney, Archaeologist Project Planning Branch Cultural Resources Preparation Ramune Morales, Project...addressed in our evaluation. Please contact Mitzy L. Schaney at (615) 736-2268 or mitzy.l.schaney@usace.army.mil if you require additional...of the phased compliance approach. Also include any concerns you would like addressed in our evaluation. Please contact Mitzy L. Schaney at (615) 736

Program for establishing long time flight service performance of composite materials in the central wing structure of C-130 aircraft. Phase 2: Detailed design

NASA Technical Reports Server (NTRS)

Harvill, W. E.; Duhig, J. J.; Spencer, B. R.

1973-01-01

The design, fabrication, and evaluation of boron-epoxy reinforced C-130 center wing boxes are discussed. Design drawings, static strength, fatigue endurance, flutter, and weight analyses required for the wing box fabrication are presented. Additional component testing to verify the design for panel buckling and to evaluate specific local design areas are reported.

Evaluation of an improved technique for lumen path definition and lumen segmentation of atherosclerotic vessels in CT angiography.

PubMed

van Velsen, Evert F S; Niessen, Wiro J; de Weert, Thomas T; de Monyé, Cécile; van der Lugt, Aad; Meijering, Erik; Stokking, Rik

2007-07-01

Vessel image analysis is crucial when considering therapeutical options for (cardio-) vascular diseases. Our method, VAMPIRE (Vascular Analysis using Multiscale Paths Inferred from Ridges and Edges), involves two parts: a user defines a start- and endpoint upon which a lumen path is automatically defined, and which is used for initialization; the automatic segmentation of the vessel lumen on computed tomographic angiography (CTA) images. Both parts are based on the detection of vessel-like structures by analyzing intensity, edge, and ridge information. A multi-observer evaluation study was performed to compare VAMPIRE with a conventional method on the CTA data of 15 patients with carotid artery stenosis. In addition to the start- and endpoint, the two radiologists required on average 2.5 (SD: 1.9) additional points to define a lumen path when using the conventional method, and 0.1 (SD: 0.3) when using VAMPIRE. The segmentation results were quantitatively evaluated using Similarity Indices, which were slightly lower between VAMPIRE and the two radiologists (respectively 0.90 and 0.88) compared with the Similarity Index between the radiologists (0.92). The evaluation shows that the improved definition of a lumen path requires minimal user interaction, and that using this path as initialization leads to good automatic lumen segmentation results.

SCRL-Model for Human Space Flight Operations Enterprise Supply Chain

NASA Technical Reports Server (NTRS)

Tucker, Brian; Paxton, Joseph

2010-01-01

This paper will present a Supply Chain Readiness Level (SCRL) model that can be used to evaluate and configure adaptable and sustainable program and mission supply chains at an enterprise level. It will also show that using SCRL in conjunction with Technology Readiness Levels (TRLs), Manufacturing Readiness Levels (MRLs) and National Aeronautics Space Administrations (NASA s) Project Lifecycle Process will provide a more complete means of developing and evaluating a robust sustainable supply chain that encompasses the entire product, system and mission lifecycle. In addition, it will be shown that by implementing the SCRL model, NASA can additionally define supplier requirements to enable effective supply chain management (SCM). Developing and evaluating overall supply chain readiness for any product, system and mission lifecycle is critical for mission success. Readiness levels are presently being used to evaluate the maturity of technology and manufacturing capability during development and deployment phases of products and systems. For example, TRLs are used to support the assessment of the maturity of a particular technology and compare maturity of different types of technologies. MRLs are designed to assess the maturity and risk of a given technology from a manufacturing perspective. In addition, when these measurement systems are used collectively they can offer a more comprehensive view of the maturity of the system. While some aspects of the supply chain and supply chain planning are considered in these familiar metric systems, certain characteristics of an effective supply chain, when evaluated in more detail, will provide an improved insight into the readiness and risk throughout the supply chain. Therefore, a system that concentrates particularly on supply chain attributes is required to better assess enterprise supply chain readiness.

The work of the European Union Reference Laboratory for Food Additives (EURL) and its support for the authorisation process of feed additives in the European Union: a review

PubMed Central

von Holst, Christoph; Robouch, Piotr; Bellorini, Stefano; de la Huebra, María José González; Ezerskis, Zigmas

2016-01-01

ABSTRACT This paper describes the operation of the European Union Reference Laboratory for Feed Additives (EURL) and its role in the authorisation procedure of feed additives in the European Union. Feed additives are authorised according to Regulation (EC) No. 1831/2003, which introduced a completely revised authorisation procedure and also established the EURL. The regulations authorising feed additives contain conditions of use such as legal limits of the feed additives, which require the availability of a suitable method of analysis for official control purposes under real world conditions. It is the task of the EURL to evaluate the suitability of analytical methods as proposed by the industry for this purpose. Moreover, the paper shows that one of the major challenges is the huge variety of the methodology applied in feed additive analysis, thus requiring expertise in quite different analytical areas. In order to cope with this challenge, the EURL is supported by a network of national reference laboratories (NRLs) and only the merged knowledge of all NRLs allows for a scientifically sound assessment of the analytical methods. PMID:26540604

Space Shuttle Program: STS-1 Medical Report

NASA Technical Reports Server (NTRS)

1981-01-01

The necessity for developing medical standards addressing individual classes of Shuttle crew positions is discussed. For the U.S. manned program the conclusion of the Apollo era heralded the end of water recovery operations and the introduction of land-based medical operations. This procedural change marked a significant departure from the accepted postflight medical recovery and evaluation techniques. All phases of the missions required careful re-evaluation, identification of potential impact on preexisting medical operational techniques, and development of new methodologies which were carefully evaluated and tested under simulated conditions. Significant coordination was required between the different teams involved in medical operations. Additional dimensions were added to the concepts of medical operations, by the introduction of different toxic substances utilized by the Space Transportation Systems especially during ground operations.

Evaluation of ARCAM Deposited Ti-6Al-4V

NASA Technical Reports Server (NTRS)

Slattery, Kevin; Slaughter, Blake; Speorl, Emily; Good, James; Gilley, Scott; McLemore, Carole

2008-01-01

A wide range of Metal Additive Manufacturing (MAM) technologies are becoming available. One of the challenges in using new technologies for aerospace systems is demonstrating that the process and system has the ability to manufacture components that meet the high quality requirements on a statistically significant basis. The widest-used system for small to medium sized components is the ARCAM system manufactured in Gothenburg, Sweden. This system features a 4kW electron-beam gun, and has a chamber volume of 250mm long x 250mm wide x 250mm to 400mm tall. This paper will describe the basis for the quality and consistency requirements, the experimental and evaluation procedures used for the evaluation, and an analysis of the results for Ti-6Al-4V.

Fluorine lubricated bearing technology

NASA Technical Reports Server (NTRS)

Mallaire, F. R.

1973-01-01

An experimental program was conducted to evaluate and select materials for ball bearings intended for use in liquid fluorine and/or FLOX. The ability of three different ball-separator materials, each containing nickel, to form and transfer a nickel fluoride film to provide effective lubrication at the required areas of a ball bearing operating in liquid fluorine was evaluated. In addition, solid lubrication of a ball bearing operating in liquid fluorine by either a fused fluoride coating applied to all surfaces of the ball separator or by a fluoride impregnation of porous sintered material ball separators was evaluated. Less bearing wear occurred when tests were conducted in the less reactive FLOX. Bearings fabricated from any of the materials tested would have relatively short wear lives and would require frequent replacement in a reusable engine.

Shuttle GPS R/PA evaluation analysis and performance tradeoff study

NASA Technical Reports Server (NTRS)

Booth, R. W. D.; Lindsey, W. C.

1978-01-01

Primary responsibility was understanding and analyzing the various GPS receiver functions as they relate to the shuttle environment. These receiver functions included acquisition properties of the sequential detector, acquisition and tracking properties of the various receiver phase locked loops, and the techniques of sequential receiver operation. In addition to these areas, support was provided in the areas of oscillator stability requirements, antenna management, and navigation filter requirements, including preposition aiding.

An Evaluation of the Network Efficiency Required in Order to Support Multicast and Synchronous Distributed Learning Network Traffic

DTIC Science & Technology

2003-09-01

This restriction limits the deployment to small and medium sized enterprises. The Internet cannot universally use DVMRP for this reason. In addition...20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE September 2003 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE... University , 1996 Submitted in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN COMPUTER SCIENCE from

Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay

PubMed Central

Logue, James; Tuznik, Kaylie; Follmann, Dean; Grandits, Greg; Marchand, Jonathan; Reilly, Cavan; Sarro, Yeya dit Sadio; Pettitt, James; Stavale, Eric J.; Fallah, Mosoka; Olinger, Gene G.; Bolay, Fatorma K.; Hensley, Lisa E.

2018-01-01

As part of the scientific community’s development of medical countermeasures against Ebola virus disease, optimization of standardized assays for product evaluation is paramount. The recent outbreak heightened awareness to the scarcity of available assays and limited information on performance and reproducibility. To evaluate the immunogenicity of vaccines entering Phase I–III trials and to identify survivors, two enzyme-linked immunosorbent assays, the Filovirus Animal Non-Clinical Group assay and the Alpha Diagnostics International assay, were evaluated for detection of immunoglobulin G against Ebola virus glycoprotein. We found that the Filovirus Animal Nonclinical Group assay produced a wider range of relative antibody concentrations, higher assay precision, larger relative accuracy range, and lower regional background. Additionally, to sufficiently power a vaccine trial, use of the Filovirus Animal Nonclinical Group assay would require one third the number of participants than the Alpha Diagnostics International assay. This reduction in needed study participants will require less money, fewer man hours, and much less time to evaluate vaccine immunogenicity. PMID:29481881

Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and Regional Malaria Elimination Strategies

PubMed Central

Conn, Jan E.; Norris, Douglas E.; Donnelly, Martin J.; Beebe, Nigel W.; Burkot, Thomas R.; Coulibaly, Mamadou B.; Chery, Laura; Eapen, Alex; Keven, John B.; Kilama, Maxwell; Kumar, Ashwani; Lindsay, Steve W.; Moreno, Marta; Quinones, Martha; Reimer, Lisa J.; Russell, Tanya L.; Smith, David L.; Thomas, Matthew B.; Walker, Edward D.; Wilson, Mark L.; Yan, Guiyun

2015-01-01

The unprecedented global efforts for malaria elimination in the past decade have resulted in altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities in malaria transmission require innovative vector control strategies in addition to the established practices of long-lasting insecticidal nets and indoor residual spraying. Integrated vector management will require focal and tailored vector control to achieve malaria elimination. This switch of emphasis from universal coverage to universal coverage plus additional interventions will be reliant on improved entomological monitoring and evaluation. In 2010, the National Institutes for Allergies and Infectious Diseases (NIAID) established a network of malaria research centers termed ICEMRs (International Centers for Excellence in Malaria Research) expressly to develop this evidence base in diverse malaria endemic settings. In this article, we contrast the differing ecology and transmission settings across the ICEMR study locations. In South America, Africa, and Asia, vector biologists are already dealing with many of the issues of pushing to elimination such as highly focal transmission, proportionate increase in the importance of outdoor and crepuscular biting, vector species complexity, and “sub patent” vector transmission. PMID:26259942

Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and Regional Malaria Elimination Strategies.

PubMed

Conn, Jan E; Norris, Douglas E; Donnelly, Martin J; Beebe, Nigel W; Burkot, Thomas R; Coulibaly, Mamadou B; Chery, Laura; Eapen, Alex; Keven, John B; Kilama, Maxwell; Kumar, Ashwani; Lindsay, Steve W; Moreno, Marta; Quinones, Martha; Reimer, Lisa J; Russell, Tanya L; Smith, David L; Thomas, Matthew B; Walker, Edward D; Wilson, Mark L; Yan, Guiyun

2015-09-01

The unprecedented global efforts for malaria elimination in the past decade have resulted in altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities in malaria transmission require innovative vector control strategies in addition to the established practices of long-lasting insecticidal nets and indoor residual spraying. Integrated vector management will require focal and tailored vector control to achieve malaria elimination. This switch of emphasis from universal coverage to universal coverage plus additional interventions will be reliant on improved entomological monitoring and evaluation. In 2010, the National Institutes for Allergies and Infectious Diseases (NIAID) established a network of malaria research centers termed ICEMRs (International Centers for Excellence in Malaria Research) expressly to develop this evidence base in diverse malaria endemic settings. In this article, we contrast the differing ecology and transmission settings across the ICEMR study locations. In South America, Africa, and Asia, vector biologists are already dealing with many of the issues of pushing to elimination such as highly focal transmission, proportionate increase in the importance of outdoor and crepuscular biting, vector species complexity, and "sub patent" vector transmission. © The American Society of Tropical Medicine and Hygiene.

Assessing direct analysis in real-time-mass spectrometry (DART-MS) for the rapid identification of additives in food packaging.

PubMed

Ackerman, L K; Noonan, G O; Begley, T H

2009-12-01

The ambient ionization technique direct analysis in real time (DART) was characterized and evaluated for the screening of food packaging for the presence of packaging additives using a benchtop mass spectrometer (MS). Approximate optimum conditions were determined for 13 common food-packaging additives, including plasticizers, anti-oxidants, colorants, grease-proofers, and ultraviolet light stabilizers. Method sensitivity and linearity were evaluated using solutions and characterized polymer samples. Additionally, the response of a model additive (di-ethyl-hexyl-phthalate) was examined across a range of sample positions, DART, and MS conditions (temperature, voltage and helium flow). Under optimal conditions, molecular ion (M+H+) was the major ion for most additives. Additive responses were highly sensitive to sample and DART source orientation, as well as to DART flow rates, temperatures, and MS inlet voltages, respectively. DART-MS response was neither consistently linear nor quantitative in this setting, and sensitivity varied by additive. All additives studied were rapidly identified in multiple food-packaging materials by DART-MS/MS, suggesting this technique can be used to screen food packaging rapidly. However, method sensitivity and quantitation requires further study and improvement.

7 CFR 210.19 - Additional responsibilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... fiscal action back to previous school years, as applicable. The State agency shall ensure that any Claim... AGRICULTURE CHILD NUTRITION PROGRAMS NATIONAL SCHOOL LUNCH PROGRAM Requirements for State Agency Participation... with School Year 1996-1997, State agencies shall evaluate compliance, over the school week, with the...

77 FR 27101 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... statement of additional information covering essential information about a separate account. Section 5(b) of the Securities Act requires that investors be provided with a prospectus containing the information... Investment Company Act and to enable filers to provide investors with information necessary to evaluate an...

Communications Arts and Technology Program Needs Assessment.

ERIC Educational Resources Information Center

Oakland Community Coll., Farmington, MI. Office of Institutional Planning and Analysis.

In 1992, Oakland Community College conducted a needs assessment study to assist in reviewing and evaluating proposed changes to the college's existing Communications Arts and Technology Program. Businesses and employers in the communications field were surveyed (n=40) regarding employment requirements and opportunities. Additional information was…

Teachers and Psychological Reports.

ERIC Educational Resources Information Center

Rogers, George W., Jr.

The importance of the written psychological report is explored, and, in particular, its relationship to teachers' needs and requirements is discussed. Additionally, the characteristics of a "good" psychological report are listed, and teachers are advised to use these criteria in evaluating the psychological reports they are receiving. (Author)

Methodology to evaluate the performance of simulation models for alternative compiler and operating system configurations

USDA-ARS?s Scientific Manuscript database

Simulation modelers increasingly require greater flexibility for model implementation on diverse operating systems, and they demand high computational speed for efficient iterative simulations. Additionally, model users may differ in preference for proprietary versus open-source software environment...

Renewable Fuel Pathways II Final Rule to Identify Additional Fuel Pathways under Renewable Fuel Standard Program

EPA Pesticide Factsheets

This final rule describes EPA’s evaluation of biofuels derived from biogas fuel pathways under the RFS program and other minor amendments related to survey requirements associated with ULSD program and misfueling mitigation regulations for E15.

Ontario's daily physical activity policy for elementary schools: is everything in place for success?

PubMed

Robertson-Wilson, Jennifer E; Lévesque, Lucie

2009-01-01

The development, implementation, and evaluation of policies may play an important role in promoting health behaviours such as physical activity. The Ontario Ministry of Education (OME) recently mandated Memorandum No. 138 requiring daily physical activity (DPA) for Ontario elementary students in grades one through eight. The purpose of this paper is to examine implementation strategies. Hogwood and Gunn's 10 preconditions for "perfect implementation" are used to examine publicly available Ministry DPA policy documents to assess whether these implementation strategies have been considered in the policy documents. Several preconditions (e.g., allocation of resources, task specification) appear to have been considered, however a number of preconditions (e.g., the sustainability of resources, extent to which the policy is valued, and evaluation plans) thought to be important require additional attention to ensure optimal DPA implementation. Additional reflection upon Hogwood and Gunn's implementation preconditions would, in our opinion, assist in facilitating optimal DPA implementation as per Memorandum No. 138.

Large Area Nondestructive Evaluation of a Fatigue Loaded Composite Structure

NASA Technical Reports Server (NTRS)

Zalameda, Joseph N.; Burke, Eric R.; Horne, Michael R.; Madaras, Eric I.

2016-01-01

Large area nondestructive evaluation (NDE) inspections are required for fatigue testing of composite structures to track damage initiation and growth. Of particular interest is the progression of damage leading to ultimate failure to validate damage progression models. In this work, passive thermography and acoustic emission NDE were used to track damage growth up to failure of a composite three-stringer panel. Fourteen acoustic emission sensors were placed on the composite panel. The signals from the array were acquired simultaneously and allowed for acoustic emission location. In addition, real time thermal data of the composite structure were acquired during loading. Details are presented on the mapping of the acoustic emission locations directly onto the thermal imagery to confirm areas of damage growth leading to ultimate failure. This required synchronizing the acoustic emission and thermal data with the applied loading. In addition, processing of the thermal imagery which included contrast enhancement, removal of optical barrel distortion and correction of angular rotation before mapping the acoustic event locations are discussed.

A Probabilistic Software System Attribute Acceptance Paradigm for COTS Software Evaluation

NASA Technical Reports Server (NTRS)

Morris, A. Terry

2005-01-01

Standard software requirement formats are written from top-down perspectives only, that is, from an ideal notion of a client s needs. Despite the exactness of the standard format, software and system errors in designed systems have abounded. Bad and inadequate requirements have resulted in cost overruns, schedule slips and lost profitability. Commercial off-the-shelf (COTS) software components are even more troublesome than designed systems because they are often provided as is and subsequently delivered with unsubstantiated validation of described capabilities. For COTS software, there needs to be a way to express the client s software needs in a consistent and formal manner using software system attributes derived from software quality standards. Additionally, the format needs to be amenable to software evaluation processes that integrate observable evidence garnered from historical data. This paper presents a paradigm that effectively bridges the gap between what a client desires (top-down) and what has been demonstrated (bottom-up) for COTS software evaluation. The paradigm addresses the specification of needs before the software evaluation is performed and can be used to increase the shared understanding between clients and software evaluators about what is required and what is technically possible.

Judgment under uncertainty; a probabilistic evaluation framework for decision-making about sanitation systems in low-income countries.

PubMed

Malekpour, Shirin; Langeveld, Jeroen; Letema, Sammy; Clemens, François; van Lier, Jules B

2013-03-30

This paper introduces the probabilistic evaluation framework, to enable transparent and objective decision-making in technology selection for sanitation solutions in low-income countries. The probabilistic framework recognizes the often poor quality of the available data for evaluations. Within this framework, the evaluations will be done based on the probabilities that the expected outcomes occur in practice, considering the uncertainties in evaluation parameters. Consequently, the outcome of evaluations will not be single point estimates; but there exists a range of possible outcomes. A first trial application of this framework for evaluation of sanitation options in the Nyalenda settlement in Kisumu, Kenya, showed how the range of values that an evaluation parameter may obtain in practice would influence the evaluation outcomes. In addition, as the probabilistic evaluation requires various site-specific data, sensitivity analysis was performed to determine the influence of each data set quality on the evaluation outcomes. Based on that, data collection activities could be (re)directed, in a trade-off between the required investments in those activities and the resolution of the decisions that are to be made. Copyright © 2013 Elsevier Ltd. All rights reserved.

Statistical analysis of stream water-quality data and sampling network design near Oklahoma City, central Oklahoma, 1977-1999

USGS Publications Warehouse

Brigham, Mark E.; Payne, Gregory A.; Andrews, William J.; Abbott, Marvin M.

2002-01-01

The sampling network was evaluated with respect to areal coverage, sampling frequency, and analytical schedules. Areal coverage could be expanded to include one additional watershed that is not part of the current network. A new sampling site on the North Canadian River might be useful because of expanding urbanization west of the city, but sampling at some other sites could be discontinued or reduced based on comparisons of data between the sites. Additional real-time or periodic monitoring for dissolved oxygen may be useful to prevent anoxic conditions in pools behind new low-water dams. The sampling schedules, both monthly and quarterly, are adequate to evaluate trends, but additional sampling during flow extremes may be needed to quantify loads and evaluate water-quality during flow extremes. Emerging water-quality issues may require sampling for volatile organic compounds, sulfide, total phosphorus, chlorophyll-a, Esherichia coli, and enterococci, as well as use of more sensitive laboratory analytical methods for determination of cadmium, mercury, lead, and silver.

Can the efficiency of modified Alvarado scoring system in the diagnosis acute appendicitis be increased with tenesmus?

PubMed

Bulus, Hakan; Tas, Adnan; Morkavuk, Baris; Koklu, Seyfettin; Soy, Derya; Coskun, Ali

2013-01-01

Acute appendicitis is one of the main pathological conditions requiring emergency surgical intervention. The most widely accepted scoring system is modified Alvarado scoring system (MASS). In this study we aimed to improve the efficiency of MASS by adding a new parameter and to evaluate its efficiency in the diagnosis of acute appendicitis. This study included 158 patients who underwent acute appendectomy in Keçiören Training and Research Hospital General Surgery Department. In addition to criteria of MASS, all patients were questioned about the presence of tenesmus. The validity of MASS and MASS with additional parameter was evaluated with respect to sensitivity, specificity and positive and negative predictive values. Accuracy rates of MASS, clinical findings, ultrasonography and MASS with additional parameter in the diagnosis of acute appendicitis were 64, 76, 85 and 80 %. False positivity rates for clinical findings, MASS and MASS with additional parameter in the diagnosis of acute appendicitis were 17, 26 and 10 %, respectively. Sensitivity and specificity of clinical findings in the diagnosis of acute appendicitis were 83 and 66 %, respectively. Sensitivity and specificity of MASS in the diagnosis of acute appendicitis were 74 and 39 %, respectively, and those of MASS with additional parameter were appendicitis increased to 83 and 66 %, respectively. MASS is a simple, cheap and objective scoring system and does not require expertise. When tenesmus is added to standard MASS, rates of accuracy, sensitivity and specificity become better than those in MASS in the diagnosis of acute appendicitis.

A Self-Adaptive Model-Based Wi-Fi Indoor Localization Method.

PubMed

Tuta, Jure; Juric, Matjaz B

2016-12-06

This paper presents a novel method for indoor localization, developed with the main aim of making it useful for real-world deployments. Many indoor localization methods exist, yet they have several disadvantages in real-world deployments-some are static, which is not suitable for long-term usage; some require costly human recalibration procedures; and others require special hardware such as Wi-Fi anchors and transponders. Our method is self-calibrating and self-adaptive thus maintenance free and based on Wi-Fi only. We have employed two well-known propagation models-free space path loss and ITU models-which we have extended with additional parameters for better propagation simulation. Our self-calibrating procedure utilizes one propagation model to infer parameters of the space and the other to simulate the propagation of the signal without requiring any additional hardware beside Wi-Fi access points, which is suitable for real-world usage. Our method is also one of the few model-based Wi-Fi only self-adaptive approaches that do not require the mobile terminal to be in the access-point mode. The only input requirements of the method are Wi-Fi access point positions, and positions and properties of the walls. Our method has been evaluated in single- and multi-room environments, with measured mean error of 2-3 and 3-4 m, respectively, which is similar to existing methods. The evaluation has proven that usable localization accuracy can be achieved in real-world environments solely by the proposed Wi-Fi method that relies on simple hardware and software requirements.

A Self-Adaptive Model-Based Wi-Fi Indoor Localization Method

PubMed Central

Tuta, Jure; Juric, Matjaz B.

2016-01-01

This paper presents a novel method for indoor localization, developed with the main aim of making it useful for real-world deployments. Many indoor localization methods exist, yet they have several disadvantages in real-world deployments—some are static, which is not suitable for long-term usage; some require costly human recalibration procedures; and others require special hardware such as Wi-Fi anchors and transponders. Our method is self-calibrating and self-adaptive thus maintenance free and based on Wi-Fi only. We have employed two well-known propagation models—free space path loss and ITU models—which we have extended with additional parameters for better propagation simulation. Our self-calibrating procedure utilizes one propagation model to infer parameters of the space and the other to simulate the propagation of the signal without requiring any additional hardware beside Wi-Fi access points, which is suitable for real-world usage. Our method is also one of the few model-based Wi-Fi only self-adaptive approaches that do not require the mobile terminal to be in the access-point mode. The only input requirements of the method are Wi-Fi access point positions, and positions and properties of the walls. Our method has been evaluated in single- and multi-room environments, with measured mean error of 2–3 and 3–4 m, respectively, which is similar to existing methods. The evaluation has proven that usable localization accuracy can be achieved in real-world environments solely by the proposed Wi-Fi method that relies on simple hardware and software requirements. PMID:27929453

Vehicle Health Management Communications Requirements for AeroMACS

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Clements, Donna J.; Apaza, Rafael D.

2012-01-01

As the development of standards for the aeronautical mobile airport communications system (AeroMACS) progresses, the process of identifying and quantifying appropriate uses for the system is progressing. In addition to defining important elements of AeroMACS standards, indentifying the systems uses impacts AeroMACS bandwidth requirements. Although an initial 59 MHz spectrum allocation for AeroMACS was established in 2007, the allocation may be inadequate; studies have indicated that 100 MHz or more of spectrum may be required to support airport surface communications. Hence additional spectrum allocations have been proposed. Vehicle health management (VHM) systems, which can produce large volumes of vehicle health data, were not considered in the original bandwidth requirements analyses, and are therefore of interest in supporting proposals for additional AeroMACS spectrum. VHM systems are an emerging development in air vehicle safety, and preliminary estimates of the amount of data that will be produced and transmitted off an aircraft, both in flight and on the ground, have been prepared based on estimates of data produced by on-board vehicle health sensors and initial concepts of data processing approaches. This allowed an initial estimate of VHM data transmission requirements for the airport surface. More recently, vehicle-level systems designed to process and analyze VHM data and draw conclusions on the current state of vehicle health have been undergoing testing and evaluation. These systems make use of vehicle system data that is mostly different from VHM data considered previously for airport surface transmission, and produce processed system outputs that will be also need to be archived, thus generating additional data load for AeroMACS. This paper provides an analysis of airport surface data transmission requirements resulting from the vehicle level reasoning systems, within the context of overall VHM data requirements.

Choosing Assessments that Matter

ERIC Educational Resources Information Center

Abilock, Debbie, Ed.

2007-01-01

Professionally, school librarians are faced with an explosion of choices--search engines, online catalogs, media types, subscription databases, and Web tools--all requiring scrutiny, evaluation, and selection. In turn, this support "stuff" forms a basis for making additional choices about how and what they teach and what they assess. Whereas once…

The Intersection of Information and Science Literacy

ERIC Educational Resources Information Center

Klucevsek, Kristin

2017-01-01

To achieve higher science literacy, both students and the public require discipline-specific information literacy in the sciences. Scientific information literacy is a core component of the scientific process. In addition to teaching how to find and evaluate resources, scientific information literacy should include teaching the process of…

Assessment in Online Courses: How Are Counseling Skills Evaluated?

ERIC Educational Resources Information Center

Cicco, Gina

2011-01-01

Online courses are a necessary addition to most graduate education programs. Offering students the option of completing program requirements online makes the program more competitive, convenient, and attractive. Responsible online instructors and program administrators must consider whether or not specific courses that are offered in the…

Mechanical Engineering Design Project report: Enabler control systems

NASA Technical Reports Server (NTRS)

Cullen, Christian; Delvecchio, Dave; Scarborough, Alan; Havics, Andrew A.

1992-01-01

The Controls Group was assigned the responsibility for designing the Enabler's control system. The requirement for the design was that the control system must provide a simple user interface to control the boom articulation joints, chassis articulation joints, and the wheel drive. The system required controlling hydraulic motors on the Enabler by implementing 8-bit microprocessor boards. In addition, feedback to evaluate positions and velocities must be interfaced to provide the operator with confirmation as well as control.

78 FR 26090 - Content Specifications and Shielding Evaluations for Type B Transportation Packages

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-03

...The U.S. Nuclear Regulatory Commission (NRC) is issuing Regulatory Issue Summary (RIS) 2013-04, ``Content Specifications and Shielding Evaluations for Type B Transportation Packages.'' This RIS clarifies the NRC's use of staff guidance in NUREG-1609, ``Standard Review Plan for Transport Packages for Radioactive Material,'' for the review of content specifications and shielding evaluations included in the Certificates of Compliance (CoC) and safety analysis reports (SARs) for Type B transportation packages. The RIS does not impose any additional regulatory requirements on NRC licensees.

An Analysis to Determine the Management Training Requirements for Civil Engineering Superintendents and Foremen.

DTIC Science & Technology

1985-09-01

34 " develop a more accurate concept of human behavior. In addition, students learn how to improve their abilities to 22 [ .". ., , . . * lead, follow...contains four volumes with 36 lessons. This block defines the arena where professional Air Force officers operate. In addition, students learn to... learned in unit A, to perform limited position classification casework, and to * -write evaluation reports. Students may either enroll in Unit A only, or in

Maritime User Requirements at High Latitudes - the MARENOR Project

NASA Astrophysics Data System (ADS)

Behlke, R.

2014-12-01

The ionosphere at high latitudes is characterised by a great variety of spatial and temporal variations that influence radio signals. In addition to navigation solutions that are based on Global Navigation Satellite Systems (GNSS), satellite communication systems also suffer from ionospheric degradation. This is worsened by harsh weather conditions, insufficient coverage by geostationary satellites and the absence of land-based augmentation infrastructure. Climate change will lead to a decrease in sea ice extent and thus to an increased use of trans-polar shipping routes, presence of gas and oil industries in the High Arctic and higher focus on Search-and-Rescue (SAR) as well as sovereignty issues. These moments usually require navigation and communication solutions that are accurate and reliable. We describe requirements presented by industrial operators on and around Svalbard. In addition, we present the MARENOR project that aims on evaluating navigation and communication systems at high latitudes including first results

Logistics for Working Together to Facilitate Genomic/Quantitative Genetic Prediction

USDA-ARS?s Scientific Manuscript database

The incorporation of DNA tests into the national cattle evaluation system will require estimation of variances of and covariances among the additive genetic components of the DNA tests and the phenotypic traits they are intended to predict. Populations with both DNA test results and phenotypes will ...

36 CFR 72.52 - Recovery Action Program grant applications.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the appropriate NPS Regional Office. (b) Submission of Applications. In addition to Standard Form 424... following documents and required attachments to NPS Regional Offices: (1) OMB Form 80-RO190, completed as...) Grant agreement form. (3) Narrative statements which will be used in evaluating grant applications in...

36 CFR 72.52 - Recovery Action Program grant applications.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the appropriate NPS Regional Office. (b) Submission of Applications. In addition to Standard Form 424... following documents and required attachments to NPS Regional Offices: (1) OMB Form 80-RO190, completed as...) Grant agreement form. (3) Narrative statements which will be used in evaluating grant applications in...

36 CFR 72.52 - Recovery Action Program grant applications.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the appropriate NPS Regional Office. (b) Submission of Applications. In addition to Standard Form 424... following documents and required attachments to NPS Regional Offices: (1) OMB Form 80-RO190, completed as...) Grant agreement form. (3) Narrative statements which will be used in evaluating grant applications in...

75 FR 2565 - Northern States Power Company, LLC; Monticello Nuclear Generating Plant Final Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... turbine, and components containing radioactive materials. Based on the licensee's evaluation, the annual... savings and still require additional generating capacity. Alternative energy sources such as wind energy.../adams.html . Persons who do not have access to ADAMS or who encounter problems in accessing the...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2013 CFR

2013-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2011 CFR

2011-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2012 CFR

2012-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2014 CFR

2014-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

NON-ADDITIVE INTERACTIONS OF AN ORGANOPHOSPHORUS PESTICIDE MIXTURE IN ADULT AND PREWEANLING RATS.

EPA Science Inventory

Critical features of risk assessment include the evaluation of risk following exposure to pesticide mixtures as well as the potential for increased sensitivity of the young. The US EPA is required to regulate pesticides acting via a common mechanism of action as a group, e.g.,...

30 CFR 285.908 - What must I include in my decommissioning notice?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What must I include in my decommissioning notice? 285.908 Section 285.908 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... the impacts previously identified and evaluated; (2) Require any additional Federal permits; or (3...

Factors to Consider When Implementing Automated Software Testing

DTIC Science & Technology

2016-11-10

programming, e.g., Java or Visual Basic.  Subject Matter Experts (SME) with firm grasp of application being automated. 2. Additional costs for setup (e.g...Abilities (KSA) required (e.g., Test and Evaluation). 2. Analyze programming skills needed (e.g., Java , C, C++, Visual Basic). 3. Compose team – testers

Investigating Engineering Practice Is Valuable for Mathematics Learning

ERIC Educational Resources Information Center

Goold, Eileen

2015-01-01

While engineering mathematics curricula often prescribe a fixed body of mathematical knowledge, this study takes a different approach; second-year engineering students are additionally required to investigate and document an aspect of mathematics used in engineering practice. A qualitative approach is used to evaluate the impact that students'…

Development of PZT-excited stroboscopic shearography for full-field nondestructive evaluation.

PubMed

Asemani, Hamidreza; Park, Jinwoo; Lee, Jung-Ryul; Soltani, Nasser

2017-05-01

Nondestructive evaluation using shearography requires a way to stress the inspection target. This technique is able to directly measure the displacement gradient distribution on the object surface. Shearography visualizes the internal structural damages as the anomalous pattern in the shearograpic fringe pattern. A piezoelectric (PZT) excitation system is able to generate loadings in the vibrational, acoustic, and ultrasonic regimes. In this paper, we propose a PZT-excited stroboscopic shearography. The PZT excitation could generate vibrational loading, a stationary wavefield, and a nonstationary propagation wave to fulfill the external loading requirement of shearography. The sweeping of the PZT excitation frequency, the formation of a standing wave, and a small shearing to suppress the incident wave were powerful controllable tools to detect the defects. The sweeping of the PZT excitation frequency enabled us to determine one of the defect-sensitive frequencies almost in real time. In addition, because the defect sensitive frequencies always existed in wide and plural ranges, the risk of the defect being overlooked by the inspector could be alleviated. The results of evaluation using stroboscopic shearography showed that an artificial 20 mm-diameter defect could be visualized at the excitation frequencies of 5-8 kHz range and 12.5-15.5 kHz range. This technique provided full field reliable and repeatable inspection results. Additionally, the proposed method overcame the important drawback of the time-averaged shearography, being required to identify the resonance vibration frequency sensitive to the defect.

Temporal Cyber Attack Detection.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ingram, Joey Burton; Draelos, Timothy J.; Galiardi, Meghan

Rigorous characterization of the performance and generalization ability of cyber defense systems is extremely difficult, making it hard to gauge uncertainty, and thus, confidence. This difficulty largely stems from a lack of labeled attack data that fully explores the potential adversarial space. Currently, performance of cyber defense systems is typically evaluated in a qualitative manner by manually inspecting the results of the system on live data and adjusting as needed. Additionally, machine learning has shown promise in deriving models that automatically learn indicators of compromise that are more robust than analyst-derived detectors. However, to generate these models, most algorithms requiremore » large amounts of labeled data (i.e., examples of attacks). Algorithms that do not require annotated data to derive models are similarly at a disadvantage, because labeled data is still necessary when evaluating performance. In this work, we explore the use of temporal generative models to learn cyber attack graph representations and automatically generate data for experimentation and evaluation. Training and evaluating cyber systems and machine learning models requires significant, annotated data, which is typically collected and labeled by hand for one-off experiments. Automatically generating such data helps derive/evaluate detection models and ensures reproducibility of results. Experimentally, we demonstrate the efficacy of generative sequence analysis techniques on learning the structure of attack graphs, based on a realistic example. These derived models can then be used to generate more data. Additionally, we provide a roadmap for future research efforts in this area.« less

Evaluation of ERDA-sponsored coal feed system development

NASA Technical Reports Server (NTRS)

Phen, R. L.; Luckow, W. K.; Mattson, L.; Otth, D.; Tsou, P.

1977-01-01

Coal feeders were evaluated based upon criteria such as technical feasibility, performance (i.e. ability to meet process requirements), projected life cycle costs, and projected development cost. An initial set of feeders was selected based on the feeders' cost savings potential compared with baseline lockhopper systems. Additional feeders were considered for selection based on: (1) increasing the probability of successful feeder development; (2) application to specific processes; and (3) technical merit. A coal feeder development program is outlined.

Adverse event rates and classifications in medial opening wedge high tibial osteotomy.

PubMed

Martin, Robin; Birmingham, Trevor B; Willits, Kevin; Litchfield, Robert; Lebel, Marie-Eve; Giffin, J Robert

2014-05-01

Previously reported complications in medial opening wedge (MOW) high tibial osteotomy (HTO) vary considerably in both rate and severity. (1) To determine the rates of adverse events in MOW HTO classified into different grades of severity based on the treatments required and (2) to compare patient-reported outcomes between the different adverse event classifications. Case series; Level of evidence, 4. All patients receiving MOW HTO at a single medical center from 2005 to 2009 were included. Internal fixation was used in all cases, with either a nonlocking (Puddu) or locking (Tomofix) plate. Patients were evaluated at 2, 6, and 12 weeks; 6 and 12 months; and annually thereafter. Types of potential surgical and postoperative adverse events, categorized into 3 classes of severity based on the subsequent treatments, were defined a priori. Medical records and radiographs were then reviewed by an independent observer. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores were compared in subgroups of patients based on the categories of adverse events observed. A total of 323 consecutive procedures (242 males) were evaluated (age, mean ± standard deviation, 46 ± 9 years; body mass index, mean ± standard deviation, 30 ± 5 kg/m(2)). Adverse events requiring no additional treatment (class 1) were undisplaced lateral cortical breaches (20%), displaced (>2 mm) lateral hinge fracture (6%), delayed wound healing (6%), undisplaced lateral tibial plateau fracture (3%), hematoma (3%), and increased tibial slope ≥10° (1%). Adverse events requiring additional or extended nonoperative management (class 2) were delayed union (12%), cellulitis (10%), limited hardware failure (1 broken screw; 4%), postoperative stiffness (1%), deep vein thrombosis (1%), and complex regional pain syndrome (CRPS) type 1 (1%). Adverse events requiring additional or revision surgery and/or long-term medical care (class 3) were aseptic nonunion (3%), deep infection (2%), CRPS type 2 (1%), and severe hardware failure with loss of correction (1%). Additional surgery rate was 3%. Class 1 and 2 adverse events did not affect patient-reported outcomes at 6, 12, or 24 months postoperatively. Patients with class 3 adverse events had significantly lower total WOMAC scores at 6 months but not at 12 or 24 months postoperatively. The most common adverse event in MOW HTO requiring extended nonoperative treatment (class 2) is delayed union (12%). The rate of severe adverse events requiring additional surgery and/or long-term medical care (class 3) is low (7%).

An evaluation of legislative measures on electrical and electronic waste in the People's Republic of China

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Shan-Shan, E-mail: sschung@hkbu.edu.hk; Zhang Chan, E-mail: abigailchanzhang@gmail.com

2011-12-15

Graphical abstract: Highlights: > The most recent specific WEEE laws of China are reviewed and evaluated. > Take-back requirement is vaguely defined. > The 'environmental expiry date' requirement is redundant. > Use of a 'multiple enforcement body' approach has hampered enforcement. - Abstract: With the increasing number of recycling mishaps in connection with waste electronic and electrical equipment (WEEE) in the People's Republic of China, it is imperative that the handling and recycling of WEEE be sufficiently regulated in China. Regulations covering three major issues, namely, take-back issues, controls on hazardous substances in WEEE and the assurance of good environmentalmore » management in WEEE plants, were promulgated between 2006 and 2008. The evaluation in this country report shows that few of these regulatory measures have performed satisfactorily in terms of enforcement, of public acceptance and of environmental concerns. In brief, the take-back requirements and the associated financial responsibilities are only vaguely defined; the control on hazardous substances and the so-called 'environmental expiry date' requirements cannot be properly enforced, and the resources needed to ensure the satisfactory enforcement of the environmental abatement and pollution control requirements in WEEE plants are overwhelming. In addition, the use of a 'multiple enforcement body' approach to the control of hazardous substances in WEEE is an indication that the Chinese government lacks the determination to properly enforce the relevant legal requirements.« less

A model for evaluating academic research centers: Case study of the Asian/Pacific Islander Youth Violence Prevention Center.

PubMed

Nishimura, Stephanie T; Hishinuma, Earl S; Goebert, Deborah A; Onoye, Jane M M; Sugimoto-Matsuda, Jeanelle J

2018-02-01

To provide one model for evaluating academic research centers, given their vital role in addressing public health issues. A theoretical framework is described for a comprehensive evaluation plan for research centers. This framework is applied to one specific center by describing the center's Logic Model and Evaluation Plan, including a sample of the center's activities. Formative and summative evaluation information is summarized. In addition, a summary of outcomes is provided: improved practice and policy; reduction of risk factors and increase in protective factors; reduction of interpersonal youth violence in the community; and national prototype for prevention of interpersonal youth violence. Research centers are important mechanisms to advance science and improve people's quality of life. Because of their more infrastructure-intensive and comprehensive approach, they also require substantial resources for success, and thus, also require careful accountability. It is therefore important to comprehensively evaluate these centers. As provided herein, a more systematic and structured approach utilizing logic models, an evaluation plan, and successful processes can provide research centers with a functionally useful method in their evaluation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay.

PubMed

Logue, James; Tuznik, Kaylie; Follmann, Dean; Grandits, Greg; Marchand, Jonathan; Reilly, Cavan; Sarro, Yeya Dit Sadio; Pettitt, James; Stavale, Eric J; Fallah, Mosoka; Olinger, Gene G; Bolay, Fatorma K; Hensley, Lisa E

2018-05-01

As part of the scientific community's development of medical countermeasures against Ebola virus disease, optimization of standardized assays for product evaluation is paramount. The recent outbreak heightened awareness to the scarcity of available assays and limited information on performance and reproducibility. To evaluate the immunogenicity of vaccines entering Phase I-III trials and to identify survivors, two enzyme-linked immunosorbent assays, the Filovirus Animal Non-Clinical Group assay and the Alpha Diagnostics International assay, were evaluated for detection of immunoglobulin G against Ebola virus glycoprotein. We found that the Filovirus Animal Nonclinical Group assay produced a wider range of relative antibody concentrations, higher assay precision, larger relative accuracy range, and lower regional background. Additionally, to sufficiently power a vaccine trial, use of the Filovirus Animal Nonclinical Group assay would require one third the number of participants than the Alpha Diagnostics International assay. This reduction in needed study participants will require less money, fewer man hours, and much less time to evaluate vaccine immunogenicity. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Simulation Evaluation of Pilot Inputs for Real Time Modeling During Commercial Flight Operations

NASA Technical Reports Server (NTRS)

Martos, Borja; Ranaudo, Richard; Oltman, Ryan; Myhre, Nick

2017-01-01

Aircraft dynamics characteristics can only be identified from flight data when the aircraft dynamics are excited sufficiently. A preliminary study was conducted into what types and levels of manual piloted control excitation would be required for accurate Real-Time Parameter IDentification (RTPID) results by commercial airline pilots. This includes assessing the practicality for the pilot to provide this excitation when cued, and to further understand if pilot inputs during various phases of flight provide sufficient excitation naturally. An operationally representative task was evaluated by 5 commercial airline pilots using the NASA Ice Contamination Effects Flight Training Device (ICEFTD). Results showed that it is practical to use manual pilot inputs only as a means of achieving good RTPID in all phases of flight and in flight turbulence conditions. All pilots were effective in satisfying excitation requirements when cued. Much of the time, cueing was not even necessary, as just performing the required task provided enough excitation for accurate RTPID estimation. Pilot opinion surveys reported that the additional control inputs required when prompted by the excitation cueing were easy to make, quickly mastered, and required minimal training.

Investigation of Propulsion System Requirements for Spartan Lite

NASA Technical Reports Server (NTRS)

Urban, Mike; Gruner, Timothy; Morrissey, James; Sneiderman, Gary

1998-01-01

This paper discusses the (chemical or electric) propulsion system requirements necessary to increase the Spartan Lite science mission lifetime to over a year. Spartan Lite is an extremely low-cost (less than 10 M) spacecraft bus being developed at the NASA Goddard Space Flight Center to accommodate sounding rocket class (40 W, 45 kg, 35 cm dia by 1 m length) payloads. While Spartan Lite is compatible with expendable launch vehicles, most missions are expected to be tertiary payloads deployed by. the Space Shuttle. To achieve a one year or longer mission life from typical Shuttle orbits, some form of propulsion system is required. Chemical propulsion systems (characterized by high thrust impulsive maneuvers) and electrical propulsion systems (characterized by low-thrust long duration maneuvers and the additional requirement for electrical power) are discussed. The performance of the Spartan Lite attitude control system in the presence of large disturbance torques is evaluated using the Trectops(Tm) dynamic simulator. This paper discusses the performance goals and resource constraints for candidate Spartan Lite propulsion systems and uses them to specify quantitative requirements against which the systems are evaluated.

Secure transport and adaptation of MC-EZBC video utilizing H.264-based transport protocols☆

PubMed Central

Hellwagner, Hermann; Hofbauer, Heinz; Kuschnig, Robert; Stütz, Thomas; Uhl, Andreas

2012-01-01

Universal Multimedia Access (UMA) calls for solutions where content is created once and subsequently adapted to given requirements. With regard to UMA and scalability, which is required often due to a wide variety of end clients, the best suited codecs are wavelet based (like the MC-EZBC) due to their inherent high number of scaling options. However, most transport technologies for delivering videos to end clients are targeted toward the H.264/AVC standard or, if scalability is required, the H.264/SVC. In this paper we will introduce a mapping of the MC-EZBC bitstream to existing H.264/SVC based streaming and scaling protocols. This enables the use of highly scalable wavelet based codecs on the one hand and the utilization of already existing network technologies without accruing high implementation costs on the other hand. Furthermore, we will evaluate different scaling options in order to choose the best option for given requirements. Additionally, we will evaluate different encryption options based on transport and bitstream encryption for use cases where digital rights management is required. PMID:26869746

RPP-PRT-58489, Revision 1, One Systems Consistent Safety Analysis Methodologies Report. 24590-WTP-RPT-MGT-15-014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Mukesh; Niemi, Belinda; Paik, Ingle

2015-09-02

In 2012, One System Nuclear Safety performed a comparison of the safety bases for the Tank Farms Operations Contractor (TOC) and Hanford Tank Waste Treatment and Immobilization Plant (WTP) (RPP-RPT-53222 / 24590-WTP-RPT-MGT-12-018, “One System Report of Comparative Evaluation of Safety Bases for Hanford Waste Treatment and Immobilization Plant Project and Tank Operations Contract”), and identified 25 recommendations that required further evaluation for consensus disposition. This report documents ten NSSC approved consistent methodologies and guides and the results of the additional evaluation process using a new set of evaluation criteria developed for the evaluation of the new methodologies.

"Dancing on the edge of research" - What is needed to build and sustain research capacity within the massage therapy profession? A formative evaluation.

PubMed

Kania-Richmond, Ania; Menard, Martha B; Barberree, Beth; Mohring, Marvin

2017-04-01

Conducting research on massage therapy (MT) continues to be a significant challenge. To explore and identify the structures, processes, and resources required to enable viable, sustainable and high quality MT research activities in the Canadian context. Academically-based researchers and MT professionals involved in research. Formative evaluation and a descriptive qualitative approach were applied. Five main themes regarding the requirements of a productive and sustainable MT research infrastructure in Canada were identified: 1) core components, 2) variable components, 3) varying perspectives of stakeholder groups, 4) barriers to creating research infrastructure, and 5) negative metaphors. In addition, participants offered a number of recommendations on how to develop such an infrastructure. While barriers exist that require attention, participants' insights suggest there are various pathways through which a productive and sustainable MT research infrastructure can be achieved. Copyright © 2016 Elsevier Ltd. All rights reserved.

MODELING AND PERFORMANCE EVALUATION FOR AVIATION SECURITY CARGO INSPECTION QUEUING SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allgood, Glenn O; Olama, Mohammed M; Rose, Terri A

Beginning in 2010, the U.S. will require that all cargo loaded in passenger aircraft be inspected. This will require more efficient processing of cargo and will have a significant impact on the inspection protocols and business practices of government agencies and the airlines. In this paper, we conduct performance evaluation study for an aviation security cargo inspection queuing system for material flow and accountability. The overall performance of the aviation security cargo inspection system is computed, analyzed, and optimized for the different system dynamics. Various performance measures are considered such as system capacity, residual capacity, and throughput. These metrics aremore » performance indicators of the system s ability to service current needs and response capacity to additional requests. The increased physical understanding resulting from execution of the queuing model utilizing these vetted performance measures will reduce the overall cost and shipping delays associated with the new inspection requirements.« less

Levothyroxine Dosing Following Bariatric Surgery.

PubMed

Gadiraju, Silpa; Lee, Clare J; Cooper, David S

2016-10-01

Based on the mechanisms of drug absorption, increased levothyroxine requirements are expected after bariatric surgery. However, there are conflicting data on this topic. This review evaluates the effects of bariatric surgery on levothyroxine dosing. Data were obtained from PubMed, Scopus, and review of published bibliographies. Six of 10 studies demonstrated decreased postoperative requirements. Most demonstrated correlations between weight loss and dose. Only 3 case reports and 1 case series demonstrated increased levothyroxine requirements, attributed to malabsorption. The loss of both fat and lean body mass may counteract malabsorptive effects from surgery, resulting in decreased postoperative levothyroxine requirements. In addition, the reversal of impaired levothyroxine pharmacokinetics and an altered set point of thyroid hormone homeostasis may also contribute to postoperative levothyroxine reductions.

Applying CBR to machine tool product configuration design oriented to customer requirements

NASA Astrophysics Data System (ADS)

Wang, Pengjia; Gong, Yadong; Xie, Hualong; Liu, Yongxian; Nee, Andrew Yehching

2017-01-01

Product customization is a trend in the current market-oriented manufacturing environment. However, deduction from customer requirements to design results and evaluation of design alternatives are still heavily reliant on the designer's experience and knowledge. To solve the problem of fuzziness and uncertainty of customer requirements in product configuration, an analysis method based on the grey rough model is presented. The customer requirements can be converted into technical characteristics effectively. In addition, an optimization decision model for product planning is established to help the enterprises select the key technical characteristics under the constraints of cost and time to serve the customer to maximal satisfaction. A new case retrieval approach that combines the self-organizing map and fuzzy similarity priority ratio method is proposed in case-based design. The self-organizing map can reduce the retrieval range and increase the retrieval efficiency, and the fuzzy similarity priority ratio method can evaluate the similarity of cases comprehensively. To ensure that the final case has the best overall performance, an evaluation method of similar cases based on grey correlation analysis is proposed to evaluate similar cases to select the most suitable case. Furthermore, a computer-aided system is developed using MATLAB GUI to assist the product configuration design. The actual example and result on an ETC series machine tool product show that the proposed method is effective, rapid and accurate in the process of product configuration. The proposed methodology provides a detailed instruction for the product configuration design oriented to customer requirements.

The role of quantitative safety evaluation in regulatory decision making of drugs.

PubMed

Chakravarty, Aloka G; Izem, Rima; Keeton, Stephine; Kim, Clara Y; Levenson, Mark S; Soukup, Mat

2016-01-01

Evaluation of safety is a critical component of drug review at the US Food and Drug Administration (FDA). Statisticians are playing an increasingly visible role in quantitative safety evaluation and regulatory decision-making. This article reviews the history and the recent events relating to quantitative drug safety evaluation at the FDA. The article then focuses on five active areas of quantitative drug safety evaluation and the role Division of Biometrics VII (DBVII) plays in these areas, namely meta-analysis for safety evaluation, large safety outcome trials, post-marketing requirements (PMRs), the Sentinel Initiative, and the evaluation of risk from extended/long-acting opioids. This article will focus chiefly on developments related to quantitative drug safety evaluation and not on the many additional developments in drug safety in general.

Performance of small cluster surveys and the clustered LQAS design to estimate local-level vaccination coverage in Mali.

PubMed

Minetti, Andrea; Riera-Montes, Margarita; Nackers, Fabienne; Roederer, Thomas; Koudika, Marie Hortense; Sekkenes, Johanne; Taconet, Aurore; Fermon, Florence; Touré, Albouhary; Grais, Rebecca F; Checchi, Francesco

2012-10-12

Estimation of vaccination coverage at the local level is essential to identify communities that may require additional support. Cluster surveys can be used in resource-poor settings, when population figures are inaccurate. To be feasible, cluster samples need to be small, without losing robustness of results. The clustered LQAS (CLQAS) approach has been proposed as an alternative, as smaller sample sizes are required. We explored (i) the efficiency of cluster surveys of decreasing sample size through bootstrapping analysis and (ii) the performance of CLQAS under three alternative sampling plans to classify local VC, using data from a survey carried out in Mali after mass vaccination against meningococcal meningitis group A. VC estimates provided by a 10 × 15 cluster survey design were reasonably robust. We used them to classify health areas in three categories and guide mop-up activities: i) health areas not requiring supplemental activities; ii) health areas requiring additional vaccination; iii) health areas requiring further evaluation. As sample size decreased (from 10 × 15 to 10 × 3), standard error of VC and ICC estimates were increasingly unstable. Results of CLQAS simulations were not accurate for most health areas, with an overall risk of misclassification greater than 0.25 in one health area out of three. It was greater than 0.50 in one health area out of two under two of the three sampling plans. Small sample cluster surveys (10 × 15) are acceptably robust for classification of VC at local level. We do not recommend the CLQAS method as currently formulated for evaluating vaccination programmes.

An opportunity cost approach to sample size calculation in cost-effectiveness analysis.

PubMed

Gafni, A; Walter, S D; Birch, S; Sendi, P

2008-01-01

The inclusion of economic evaluations as part of clinical trials has led to concerns about the adequacy of trial sample size to support such analysis. The analytical tool of cost-effectiveness analysis is the incremental cost-effectiveness ratio (ICER), which is compared with a threshold value (lambda) as a method to determine the efficiency of a health-care intervention. Accordingly, many of the methods suggested to calculating the sample size requirements for the economic component of clinical trials are based on the properties of the ICER. However, use of the ICER and a threshold value as a basis for determining efficiency has been shown to be inconsistent with the economic concept of opportunity cost. As a result, the validity of the ICER-based approaches to sample size calculations can be challenged. Alternative methods for determining improvements in efficiency have been presented in the literature that does not depend upon ICER values. In this paper, we develop an opportunity cost approach to calculating sample size for economic evaluations alongside clinical trials, and illustrate the approach using a numerical example. We compare the sample size requirement of the opportunity cost method with the ICER threshold method. In general, either method may yield the larger required sample size. However, the opportunity cost approach, although simple to use, has additional data requirements. We believe that the additional data requirements represent a small price to pay for being able to perform an analysis consistent with both concept of opportunity cost and the problem faced by decision makers. Copyright (c) 2007 John Wiley & Sons, Ltd.

System-Level Logistics for Dual Purpose Canister Disposal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinina, Elena A.

2014-06-03

The analysis presented in this report investigated how the direct disposal of dual purpose canisters (DPCs) may be affected by the use of standard transportation aging and disposal canisters (STADs), early or late start of the repository, and the repository emplacement thermal power limits. The impacts were evaluated with regard to the availability of the DPCs for emplacement, achievable repository acceptance rates, additional storage required at an interim storage facility (ISF) and additional emplacement time compared to the corresponding repackaging scenarios, and fuel age at emplacement. The result of this analysis demonstrated that the biggest difference in the availability ofmore » UNF for emplacement between the DPC-only loading scenario and the DPCs and STADs loading scenario is for a repository start date of 2036 with a 6 kW thermal power limit. The differences are also seen in the availability of UNF for emplacement between the DPC-only loading scenario and the DPCs and STADs loading scenario for the alternative with a 6 kW thermal limit and a 2048 start date, and for the alternatives with a 10 kW thermal limit and 2036 and 2048 start dates. The alternatives with disposal of UNF in both DPCs and STADs did not require additional storage, regardless of the repository acceptance rate, as compared to the reference repackaging case. In comparison to the reference repackaging case, alternatives with the 18 kW emplacement thermal limit required little to no additional emplacement time, regardless of the repository start time, the fuel loading scenario, or the repository acceptance rate. Alternatives with the 10 kW emplacement thermal limit and the DPCs and STADs fuel loading scenario required some additional emplacement time. The most significant decrease in additional emplacement time occurred in the alternative with the 6 kW thermal limit and the 2036 repository starting date. The average fuel age at emplacement ranges from 46 to 88 years. The maximum fuel age at emplacement ranges from 81 to 146 years. The difference in the average and maximum age of fuel at emplacement between the DPC-only and the DPCs and STADs fuel loading scenarios becomes less significant as the repository thermal limit increases and as the repository start date increases. In general, the role of STADs is to store young (30 year or younger) high burnup (45 GWD/MTU or higher) fuel. Recommendations for future study include detailed evaluation of the feasible alternatives with regard to the costs and factors not considered in this analysis, such as worker dose, dose to members of the public, and economic benefits to host entities. It is also recommended to conduct an additional analysis to evaluate the assumption regarding the transportability and disposability of DPCs for the next iteration of the direct disposal of DPCs study.« less

Multipurpose Crew Restraints for Long Duration Space Flights

NASA Technical Reports Server (NTRS)

Whitmore, Mihriban; Baggerman, Susan; Ortiz, M. R.; Hua, L.; Sinnott, P.; Webb, L.

2004-01-01

With permanent human presence onboard the International Space Station (ISS), a crew will be living and working in microgravity, interfacing with their physical environment. Without optimum restraints and mobility aids (R&MA' s), the crewmembers may be handicapped for perfonning some of the on-orbit tasks. In addition to weightlessness, the confined nature of a spacecraft environment results in ergonomic challenges such as limited visibility and access to the activity area and may cause prolonged periods of unnatural postures. Thus, determining the right set of human factors requirements and providing an ergonomically designed environment are crucial to astronauts' well-being and productivity. The purpose of this project is to develop requirements and guidelines, and conceptual designs, for an ergonomically designed multi-purpose crew restraint. In order to achieve this goal, the project would involve development of functional and human factors requirements, design concept prototype development, analytical and computer modeling evaluations of concepts, two sets of micro gravity evaluations and preparation of an implementation plan. It is anticipated that developing functional and design requirements for a multi-purpose restraint would facilitate development of ergonomically designed restraints to accommodate the off-nominal but repetitive tasks, and minimize the performance degradation due to lack of optimum setup for onboard task performance. In addition, development of an ergonomically designed restraint concept prototype would allow verification and validation of the requirements defined. To date, we have identified "unique" tasks and areas of need, determine characteristics of "ideal" restraints, and solicit ideas for restraint and mobility aid concepts. Focus group meetings with representatives from training, safety, crew, human factors, engineering, payload developers, and analog environment representatives were key to assist in the development of a restraint concept based on previous flight experiences, the needs of future tasks, and crewmembers' preferences. Also, a catalog with existing IVA/EVA restraint and mobility aids has been developed. Other efforts included the ISS crew debrief data on restraints, compilation of data from MIR, Skylab and ISS on restraints, and investigating possibility of an in-flight evaluation of current restraint systems. Preliminary restraint concepts were developed and presented to long duration crewmembers and focus groups for feedback. Currently, a selection criterion is being refined for prioritizing the candidate concepts. Next steps include analytical and computer modeling evaluations of the selected candidate concepts, prototype development, and microgravity evaluations.

Earth recovery mode analysis for a Martian sample return mission

NASA Technical Reports Server (NTRS)

Green, J. P.

1978-01-01

The analysis has concerned itself with evaluating alternative methods of recovering a sample module from a trans-earth trajectory originating in the vicinity of Mars. The major modes evaluated are: (1) direct atmospheric entry from trans-earth trajectory; (2) earth orbit insertion by retropropulsion; and (3) atmospheric braking to a capture orbit. In addition, the question of guided vs. unguided entry vehicles was considered, as well as alternative methods of recovery after orbit insertion for modes (2) and (3). A summary of results and conclusions is presented. Analytical results for aerodynamic and propulsive maneuvering vehicles are discussed. System performance requirements and alternatives for inertial systems implementation are also discussed. Orbital recovery operations and further studies required to resolve the recovery mode issue are described.

Survey and evaluation of multilayer insulation heat transfer measurements

NASA Astrophysics Data System (ADS)

Doenecke, Jochen

About 40 papers treating multilayer insulations were studied and compared. Most of these papers present heat transfer measurements in addition to thermal analysis. Here the equations are given which are required for an evaluation of the measurements and in particular for comparisons. Equations are presented which are required to predict the influences of the packing density, temperatures, fraction of perforation area and interstitial pressure. The equation giving gas conductivity versus pressure is modified according to measurements. In space the interstitial pressure is usually below 0.01 Pa and the heat transfer can be expressed as the sum of a conductive and radiative term. The equation finally proposed for spacecraft permits to consider the influence of temperature, number of layers, blanket size and perforation area.

Modeling of Dipole and Quadrupole Fringe-Field Effects for the Advanced Photon Source Upgrade Lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borland, M.; Lindberg, R.

2017-06-01

The proposed upgrade of the Advanced Photon Source (APS) to a multibend-achromat lattice requires shorter and much stronger quadrupole magnets than are present in the existing ring. This results in longitudinal gradient profiles that differ significantly from a hard-edge model. Additionally, the lattice assumes the use of five-segment longitudinal gradient dipoles. Under these circumstances, the effects of fringe fields and detailed field distributions are of interest. We evaluated the effect of soft-edge fringe fields on the linear optics and chromaticity, finding that compensation for these effects is readily accomplished. In addition, we evaluated the reliability of standard methods of simulatingmore » hardedge nonlinear fringe effects in quadrupoles.« less

High Resolution Visualization Applied to Future Heavy Airlift Concept Development and Evaluation

NASA Technical Reports Server (NTRS)

FordCook, A. B.; King, T.

2012-01-01

This paper explores the use of high resolution 3D visualization tools for exploring the feasibility and advantages of future military cargo airlift concepts and evaluating compatibility with existing and future payload requirements. Realistic 3D graphic representations of future airlifters are immersed in rich, supporting environments to demonstrate concepts of operations to key personnel for evaluation, feedback, and development of critical joint support. Accurate concept visualizations are reviewed by commanders, platform developers, loadmasters, soldiers, scientists, engineers, and key principal decision makers at various stages of development. The insight gained through the review of these physically and operationally realistic visualizations is essential to refining design concepts to meet competing requirements in a fiscally conservative defense finance environment. In addition, highly accurate 3D geometric models of existing and evolving large military vehicles are loaded into existing and proposed aircraft cargo bays. In this virtual aircraft test-loading environment, materiel developers, engineers, managers, and soldiers can realistically evaluate the compatibility of current and next-generation airlifters with proposed cargo.

[Evaluation of fetomaternal hemorrhage in postpartum patients with indication for administration of anti-D immunoglobulin].

PubMed

Baiochi, Eduardo; Camano, Luiz; Bordin, José Orlando

2005-01-01

This study evaluated fetomaternal hemorrhage (FMH) in 343 postpartum patients who required prophylaxis of Rh alloimmunization with anti-D immunoglobulin. The rosette test was applied to screen for patients needing quantitative determination of fetal blood transferred from the maternal circulation, which was then measured by the Kleihauer-Betke test (K-B). The rosette test was positive in 22 cases (6.4%). In five of these cases, K-B did not show fetomaternal hemorrhage (a 1.45% false-positive rate for the rosette test), and in one case the test was inconclusive. There were 8 cases with FMH < 10 ml (2.3%), 6 cases with FMH from 10 to 30 ml (1.7%), and two cases with FMH > 30 ml (0.58%), requiring a supplementary dose of anti-D. The study concludes that following the rosette test, additional evaluation of FMH using a quantitative test was unnecessary in 93.6% of the cases.

40 CFR 80.161 - Detergent additive certification program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... corresponding test results (percent flow restriction demonstrated in the PFID test and milligrams of deposit per... penalties in §§ 80.169 and 80.172. (iii) If both parties submit the required information, EPA will evaluate... customers who use the disqualified detergent. Failure to do so may subject the certifier to liabilities for...

Evaluating the Cognitive Consequences of Playing "Portal" for a Short Duration

ERIC Educational Resources Information Center

Adams, Deanne M.; Pilegard, Celeste; Mayer, Richard E.

2016-01-01

Learning physics often requires overcoming common misconceptions based on naïve interpretations of observations in the everyday world. One proposed way to help learners build appropriate physics intuitions is to expose them to computer simulations in which motion is based on Newtonian principles. In addition, playing video games that require…

75 FR 70266 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

... Nutrition Facts label format to require, the Agency undertook consumer research to evaluate alternatives (Refs. 1, 2, and 3). More recently, FDA conducted qualitative consumer research on the format of the.... 5). In addition to conducting consumer research, in response to the OWG plan FDA issued two advance...

78 FR 37651 - Agency Information Collection Activities: Request for Comments for a New Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

...- 493-3064, Nondestructive Evaluation Research Program, Federal Highway Administration, Department of... date of enactment of MAP-21. Additionally, MAP-21 included a requirement for a study on the benefits... NHS. The goal of this project shall be to complete a study of the benefits, cost- effectiveness, and...

77 FR 38191 - Approval and Promulgation of Implementation Plans; State of Mississippi; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... resulting under CAIR and the Transport Rule, and that Mississippi ``need[s] to base its LTS on concrete... the 2002 base year, considering growth and additional emissions controls to be in place and federally... isolation from the reasonable progress requirements. We have on several occasions undertaken evaluations of...

Post-wildfire seeding to restore native vegetation and limit exotic annuals: an evaluation in juniper-dominated sagebrush steppe

USDA-ARS?s Scientific Manuscript database

Reestablishment of perennial vegetation is often need after wildfires to limit exotic species and restore ecosystem services. Some ecosystems, however, are resilient to disturbance and resistant to exotic plant invasions and do not require restoration efforts. If restoration is needed, an addition...

75 FR 65710 - Current Value of Funds Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-26

.... Treasury's Cash Management Requirements (TFM Volume I, Part 6, Chapter 8000) prescribe use of this rate by agencies as a comparison point in evaluating the cost-effectiveness of a cash discount. In addition, 5 CFR... with Federal Cash Management systems and is based on investment rates set for purposes of Public Law 95...

On the Use of Software Metrics as a Predictor of Software Security Problems

DTIC Science & Technology

2013-01-01

models to determine if additional metrics are required to increase the accuracy of the model: non-security SCSA warnings, code churn and size, the...vulnerabilities reported by testing and those found in the field. Summary of Most Important Results We evaluated our model on three commercial telecommunications

Job Evaluation in the FE Corporation. Mendip Papers. MP 050.

ERIC Educational Resources Information Center

Saunders, Bob

This report is based on research findings indicating that many British colleges of further education have widely disparate salaries for professional staff members. Often salaries bear no relation to complexity of work performed. In addition, equal employment opportunity laws requiring equal pay for similar work may not be followed. A job…

Meeting the measurement uncertainty and traceability requirements of ISO/AEC standard 17025 in chemical analysis.

PubMed

King, B

2001-11-01

The new laboratory accreditation standard, ISO/IEC 17025, reflects current thinking on good measurement practice by requiring more explicit and more demanding attention to a number of activities. These include client interactions, method validation, traceability, and measurement uncertainty. Since the publication of the standard in 1999 there has been extensive debate about its interpretation. It is the author's view that if good quality practices are already in place and if the new requirements are introduced in a manner that is fit for purpose, the additional work required to comply with the new requirements can be expected to be modest. The paper argues that the rigour required in addressing the issues should be driven by customer requirements and the factors that need to be considered in this regard are discussed. The issues addressed include the benefits, interim arrangements, specifying the analytical requirement, establishing traceability, evaluating the uncertainty and reporting the information.

Education, Postgraduate Training, Board Certification, and Experience Requirements in Advertisements for Clinical Faculty Positions

PubMed Central

Hawkey, Lisa

2010-01-01

Objectives To compare requirements for pharmacy practice faculty positions in advertisements from 2002 through 2006 to those reported from 1990 through 1994. Methods Positions advertised from January 2002 through December 2006 in 3 newsletters and journals were evaluated for required or preferred degree, completion of residencies and/or fellowships, years of work experience, board certification, and other postgraduate training and education. Advertisements were separated by tenure-eligibility and rank. Results Of 426 advertisements for faculty members, 77% required additional training, including residencies and fellowships or their equivalent in experience. Board certification was required in only 0.9% but preferred in 11%. Advertisements for tenure-eligible positions did not have more extensive requirements than nontenured, nor did upper vs. lower rank. Conclusions Compared to 1996, the number of advertisements requiring postgraduate training to secure a faculty position almost doubled. Whether the qualifications of faculty members recruited match the requirements is unknown. PMID:20585435

Education, postgraduate training, board certification, and experience requirements in advertisements for clinical faculty positions.

PubMed

Murphy, John E; Hawkey, Lisa

2010-05-12

To compare requirements for pharmacy practice faculty positions in advertisements from 2002 through 2006 to those reported from 1990 through 1994. Positions advertised from January 2002 through December 2006 in 3 newsletters and journals were evaluated for required or preferred degree, completion of residencies and/or fellowships, years of work experience, board certification, and other postgraduate training and education. Advertisements were separated by tenure-eligibility and rank. Of 426 advertisements for faculty members, 77% required additional training, including residencies and fellowships or their equivalent in experience. Board certification was required in only 0.9% but preferred in 11%. Advertisements for tenure-eligible positions did not have more extensive requirements than nontenured, nor did upper vs. lower rank. Compared to 1996, the number of advertisements requiring postgraduate training to secure a faculty position almost doubled. Whether the qualifications of faculty members recruited match the requirements is unknown.

Post-Closure Report for Closed Resource Conservation and Recovery Act Corrective Action Units, Nevada National Security Site, Nevada, for Fiscal Year 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silvas, Alissa J.

2015-01-01

This report serves as the combined annual report for post-closure activities for several Corrective Action Units (CAUs). The locations of the sites are shown in Figure 1. This report covers fiscal year 2014 (October 2013–September 2014). The post-closure requirements for these sites are described in Resource Conservation and Recovery Act Permit Number NEV HW0101 and summarized in each CAU-specific section in Section 1.0 of this report. The results of the inspections, a summary of maintenance activities, and an evaluation of monitoring data are presented in this report. Site inspections are conducted semiannually at CAUs 90 and 91 and quarterly atmore » CAUs 92, 110, 111, and 112. Additional inspections are conducted at CAU 92 if precipitation occurs in excess of 0.50 inches (in.) in a 24-hour period and at CAU 111 if precipitation occurs in excess of 1.0 in. in a 24-hour period. Inspections include an evaluation of the condition of the units, including covers, fences, signs, gates, and locks. In addition to visual inspections, soil moisture monitoring, vegetation evaluations, and subsidence surveys are conducted at CAU 110. At CAU 111, soil moisture monitoring, vegetation evaluations, subsidence surveys, direct radiation monitoring, air monitoring, radon flux monitoring, and groundwater monitoring are conducted. The results of the vegetation surveys and an analysis of the soil moisture monitoring data at CAU 110 are presented in this report. Results of additional monitoring at CAU 111 are documented annually in the Nevada National Security Site Waste Management Monitoring Report Area 3 and Area 5 Radioactive Waste Management Sites and in the Nevada National Security Site Data Report: Groundwater Monitoring Program Area 5 Radioactive Waste Management Site, which will be prepared in approximately June 2015. All required inspections, maintenance, and monitoring were conducted in accordance with the post-closure requirements of the permit. It is recommended to continue inspections and monitoring as scheduled.« less

Robotic tape library system level testing at NSA: Present and planned

NASA Technical Reports Server (NTRS)

Shields, Michael F.

1994-01-01

In the present of declining Defense budgets, increased pressure has been placed on the DOD to utilize Commercial Off the Shelf (COTS) solutions to incrementally solve a wide variety of our computer processing requirements. With the rapid growth in processing power, significant expansion of high performance networking, and the increased complexity of applications data sets, the requirement for high performance, large capacity, reliable and secure, and most of all affordable robotic tape storage libraries has greatly increased. Additionally, the migration to a heterogeneous, distributed computing environment has further complicated the problem. With today's open system compute servers approaching yesterday's supercomputer capabilities, the need for affordable, reliable secure Mass Storage Systems (MSS) has taken on an ever increasing importance to our processing center's ability to satisfy operational mission requirements. To that end, NSA has established an in-house capability to acquire, test, and evaluate COTS products. Its goal is to qualify a set of COTS MSS libraries, thereby achieving a modicum of standardization for robotic tape libraries which can satisfy our low, medium, and high performance file and volume serving requirements. In addition, NSA has established relations with other Government Agencies to complete this in-house effort and to maximize our research, testing, and evaluation work. While the preponderance of the effort is focused at the high end of the storage ladder, considerable effort will be extended this year and next at the server class or mid range storage systems.

Extreme Temperature Operation of a 10 MHz Silicon Oscillator Type STCL1100

NASA Technical Reports Server (NTRS)

Patterson, Richard L.; Hammoud, Ahmad

2008-01-01

The performance of STMicroelectronics 10 MHz silicon oscillator was evaluated under exposure to extreme temperatures. The oscillator was characterized in terms of its output frequency stability, output signal rise and fall times, duty cycle, and supply current. The effects of thermal cycling and re-start capability at extreme low and high temperatures were also investigated. The silicon oscillator chip operated well with good stability in its output frequency over the temperature region of -50 C to +130 C, a range that by far exceeded its recommended specified boundaries of -20 C to +85 C. In addition, this chip, which is a low-cost oscillator designed for use in applications where great accuracy is not required, continued to function at cryogenic temperatures as low as - 195 C but at the expense of drop in its output frequency. The STCL1100 silicon oscillator was also able to re-start at both -195 C and +130 C, and it exhibited no change in performance due to the thermal cycling. In addition, no physical damage was observed in the packaging material due to extreme temperature exposure and thermal cycling. Therefore, it can be concluded that this device could potentially be used in space exploration missions under extreme temperature conditions in microprocessor and other applications where tight clock accuracy is not critical. In addition to the aforementioned screening evaluation, additional testing, however, is required to fully establish the reliability of these devices and to determine their suitability for long-term use.

Technical note: In vitro digestibility of amylase-treated, ash-corrected neutral detergent fiber, with addition of sodium sulfite, at 240 hours with or without rumen fluid reinoculation.

PubMed

Palmonari, A; Canestrari, G; Bonfante, E; Fustini, M; Mammi, L; Formigoni, A

2017-02-01

Long-term in vitro fermentation (240 h) evaluating amylase-treated, ash-corrected neutral detergent fiber, with addition of sodium sulfite (aNDFom) digestibility is required to quantify the indigestible fiber fraction. It is commonly accepted to inoculate rumen fluid more than one time during such fermentations, every 96 h or at 120 h. However, no studies have been conducted to verify if the reinoculation is actually required to properly carry out the fermentation process. The current study aims to evaluate the effects of these procedures on aNDFom digestibility at 240 h. The study was conducted on a total of 24 forage samples (8 alfalfa hays, 8 grass hays, and 8 corn silages). Samples were digested in triplicate at 240 h in vitro. Rumen fluid was added twice (at 96 and 192 h) in treatment 1, after 120 h in treatment 2, whereas no addition was made in treatment 3. At the end of the fermentations, residual aNDFom was quantified to calculate digestibility. Among treatments, no difference was found in digestibility of aNDFom. Moreover, treatment 1 resulted in higher variability compared with other treatments. Results obtained in the current study show that subsequent addition of rumen fluid is not necessary for a proper estimation of aNDFom digestibility, and can be avoided. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Design and Application of the Exploration Maintainability Analysis Tool

NASA Technical Reports Server (NTRS)

Stromgren, Chel; Terry, Michelle; Crillo, William; Goodliff, Kandyce; Maxwell, Andrew

2012-01-01

Conducting human exploration missions beyond Low Earth Orbit (LEO) will present unique challenges in the areas of supportability and maintainability. The durations of proposed missions can be relatively long and re-supply of logistics, including maintenance and repair items, will be limited or non-existent. In addition, mass and volume constraints in the transportation system will limit the total amount of logistics that can be flown along with the crew. These constraints will require that new strategies be developed with regards to how spacecraft systems are designed and maintained. NASA is currently developing Design Reference Missions (DRMs) as an initial step in defining future human missions. These DRMs establish destinations and concepts of operation for future missions, and begin to define technology and capability requirements. Because of the unique supportability challenges, historical supportability data and models are not directly applicable for establishing requirements for beyond LEO missions. However, supportability requirements could have a major impact on the development of the DRMs. The mass, volume, and crew resources required to support the mission could all be first order drivers in the design of missions, elements, and operations. Therefore, there is a need for enhanced analysis capabilities to more accurately establish mass, volume, and time requirements for supporting beyond LEO missions. Additionally, as new technologies and operations are proposed to reduce these requirements, it is necessary to have accurate tools to evaluate the efficacy of those approaches. In order to improve the analysis of supportability requirements for beyond LEO missions, the Space Missions Analysis Branch at the NASA Langley Research Center is developing the Exploration Maintainability Analysis Tool (EMAT). This tool is a probabilistic simulator that evaluates the need for repair and maintenance activities during space missions and the logistics and crew requirements to support those activities. Using a Monte Carlo approach, the tool simulates potential failures in defined systems, based on established component reliabilities, and then evaluates the capability of the crew to repair those failures given a defined store of spares and maintenance items. Statistical analysis of Monte Carlo runs provides probabilistic estimates of overall mission safety and reliability. This paper will describe the operation of the EMAT, including historical data sources used to populate the model, simulation processes, and outputs. Analysis results are provided for a candidate exploration system, including baseline estimates of required sparing mass and volume. Sensitivity analysis regarding the effectiveness of proposed strategies to reduce mass and volume requirements and improve mission reliability is included in these results.

The Prospects of Accounting at Mining Enterprises as a Factor of Ensuring their Sustainable Development

NASA Astrophysics Data System (ADS)

Tyuleneva, Tatiana

2017-11-01

One of the problems of sustainable development of mining companies is attracting additional investment. To solve it requires access to international capital markets, in this context, enterprises need to prepare financial statements with international requirements based on the data generated by the accounting system. The article considers the basic problems of accounting in the extractive industries due to the nature of the industry, as well as evaluation of the completeness of their solution in the framework of international financial reporting standards. In addition, lists the characteristics of accounting for mining industry, due to the peculiarities of the production process that need to be considered to solve these problems. This sector is extremely important for individual countries and on a global scale.

Low-thrust chemical propulsion system pump technology

NASA Technical Reports Server (NTRS)

Sabiers, R. L.; Siebenhaar, A.

1981-01-01

Candidate pump and driver systems for low thrust cargo orbit transfer vehicle engines which deliver large space structures to geosynchronous equatorial orbit and beyond are evaluated. The pumps operate to 68 atmospheres (1000 psi) discharge pressure and flowrates suited to cryogenic engines using either LOX/methane or LOX/hydrogen propellants in thrust ranges from 445 to 8900 N (100 to 2000 lb F). Analysis of the various pumps and drivers indicate that the low specific speed requirement will make high fluid efficiencies difficult to achieve. As such, multiple stages are required. In addition, all pumps require inducer stages. The most attractive main pumps are the multistage centrifugal pumps.

Uprated fine guidance sensor study

NASA Technical Reports Server (NTRS)

1984-01-01

Future orbital observatories will require star trackers of extremely high precision. These sensors must maintain high pointing accuracy and pointing stability simultaneously with a low light level signal from a guide star. To establish the fine guidance sensing requirements and to evaluate candidate fine guidance sensing concepts, the Space Telescope Optical Telescope Assembly was used as the reference optical system. The requirements review was separated into three areas: Optical Telescope Assembly (OTA), Fine Guidance Sensing and astrometry. The results show that the detectors should be installed directly onto the focal surface presented by the optics. This would maximize throughput and minimize point stability error by not incoporating any additional optical elements.

Mars rover 1988 concepts

NASA Technical Reports Server (NTRS)

Pivirotto, Donna Shirley; Penn, Thomas J.; Dias, William C.

1989-01-01

Results of FY88 studies of a sample-collecting Mars rover are presented. A variety of rover concepts are discussed which include different technical approaches to rover functions. The performance of rovers with different levels of automation is described and compared to the science requirement for 20 to 40 km to be traversed on the Martian surface and for 100 rock and soil samples to be collected. The analysis shows that a considerable amount of automation in roving and sampling is required to meet this requirement. Additional performance evaluation shows that advanced RTG's producing 500 W and 350 WHr of battery storage are needed to supply the rover.

Psychobiological responses to critically evaluated multitasking.

PubMed

Wetherell, Mark A; Craw, Olivia; Smith, Kenny; Smith, Michael A

2017-12-01

In order to understand psychobiological responses to stress it is necessary to observe how people react to controlled stressors. A range of stressors exist for this purpose; however, laboratory stressors that are representative of real life situations provide more ecologically valid opportunities for assessing stress responding. The current study assessed psychobiological responses to an ecologically valid laboratory stressor involving multitasking and critical evaluation. The stressor elicited significant increases in psychological and cardiovascular stress reactivity; however, no cortisol reactivity was observed. Other socially evaluative laboratory stressors that lead to cortisol reactivity typically require a participant to perform tasks that involve verbal responses, whilst standing in front of evaluative others. The current protocol contained critical evaluation of cognitive performance; however, this was delivered from behind a seated participant. The salience of social evaluation may therefore be related to the response format of the task and the method of evaluation. That is, the current protocol did not involve the additional vulnerability associated with in person, face-to-face contact, and verbal delivery. Critical evaluation of multitasking provides an ecologically valid technique for inducing laboratory stress and provides an alternative tool for assessing psychological and cardiovascular reactivity. Future studies could additionally use this paradigm to investigate those components of social evaluation necessary for eliciting a cortisol response.

Preparticipation evaluation of novice, middle-age, long-distance runners.

PubMed

Aagaard, Philip; Sahlén, Anders; Bergfeldt, Lennart; Braunschweig, Frieder

2013-01-01

The purpose of this study was to assess the cardiovascular health and risk profile in middle-age men making an entry to participate for their first time in a long-distance race. Male first-time participants, 45 yr and older, in the world's largest cross-country running race, the Lidingöloppet, were evaluated with a medical history and physical examination, European systematic coronary risk evaluation (SCORE), 12-lead ECG, echocardiography, and blood tests. Further diagnostic workup was performed when clinically indicated. Of 265 eligible runners, 153 (58%, age 51 ± 5 yr) completed the study. Although the 10-yr fatal cardiovascular event risk was low (SCORE, 1%; interquartile range, 0%-1%), mild abnormalities were common, for example, elevated blood pressure (19%), left ventricular hypertrophy (6%), and elevated LDL cholesterol (5%). ECG changes compatible with the "athlete's heart" were present in 82%, for example, sinus bradycardia (61%) and/or early repolarization (32%). ECG changes considered training unrelated were found in 24%, for example, prolonged QTc-interval (13%), left axis deviation (5.3%), and left atrial enlargement (4%). In 14 runners (9%), additional diagnostic workup was clinically motivated, and 4 runners (2%) were ultimately discouraged from vigorous exercise because of QTc intervals >500 ms (n = 2), symptomatic atrioventricular block (n = 1), and cardiac tumor (n = 1). The physician examination and the ECG identified 12 of the 14 participants requiring further evaluation. Cardiovascular evaluation of middle-age men, including a physician examination and a 12-lead ECG, appears useful to identify individuals requiring further testing before vigorous exercise. The additional yield of routine echocardiography was small.

Benefits from additives and xylanase during enzymatic hydrolysis of bamboo shoot and mature bamboo.

PubMed

Li, Kena; Wang, Xiao; Wang, Jingfeng; Zhang, Junhua

2015-09-01

Effects of additives (BSA, PEG 6000, and Tween 80) on enzymatic hydrolysis of bamboo shoot and mature bamboo fractions (bamboo green, bamboo timber, bamboo yellow, bamboo node, and bamboo branches) by cellulases and/or xylanase were evaluated. The addition of additives was comparable to the increase of cellulase loadings in the conversion of cellulose and xylan in bamboo fractions. Supplementation of xylanase (1 mg/g DM) with cellulases (10 FPU/g DM) in the hydrolysis of bamboo fractions was more efficient than addition of additives in the production of glucose and xylose. Moreover, addition of additives could further increase the glucose release from different bamboo fractions by cellulases and xylanase. Bamboo green exhibited the lowest hydrolyzability. Almost all of the polysaccharides in pretreated bamboo shoot fractions were hydrolyzed by cellulases with the addition of additives or xylanase. Additives and xylanase showed great potential for reducing cellulase requirement in the hydrolysis of bamboo. Copyright © 2015 Elsevier Ltd. All rights reserved.

Single point estimation of phenytoin dosing: a reappraisal.

PubMed

Koup, J R; Gibaldi, M; Godolphin, W

1981-11-01

A previously proposed method for estimation of phenytoin dosing requirement using a single serum sample obtained 24 hours after intravenous loading dose (18 mg/Kg) has been re-evaluated. Using more realistic values for the volume of distribution of phenytoin (0.4 to 1.2 L/Kg), simulations indicate that the proposed method will fail to consistently predict dosage requirements. Additional simulations indicate that two samples obtained during the 24 hour interval following the iv loading dose could be used to more reliably predict phenytoin dose requirement. Because of the nonlinear relationship which exists between phenytoin dose administration rate (RO) and the mean steady state serum concentration (CSS), small errors in prediction of the required RO result in much larger errors in CSS.

Structural analysis for preliminary design of High Speed Civil Transport (HSCT)

NASA Technical Reports Server (NTRS)

Bhatia, Kumar G.

1992-01-01

In the preliminary design environment, there is a need for quick evaluation of configuration and material concepts. The simplified beam representations used in the subsonic, high aspect ratio wing platform are not applicable for low aspect ratio configurations typical of supersonic transports. There is a requirement to develop methods for efficient generation of structural arrangement and finite element representation to support multidisciplinary analysis and optimization. In addition, empirical data bases required to validate prediction methods need to be improved for high speed civil transport (HSCT) type configurations.

Hydrogen aircraft technology

NASA Technical Reports Server (NTRS)

Brewer, G. D.

1991-01-01

A comprehensive evaluation is conducted of the technology development status, economics, commercial feasibility, and infrastructural requirements of LH2-fueled aircraft, with additional consideration of hydrogen production, liquefaction, and cryostorage methods. Attention is given to the effects of LH2 fuel cryotank accommodation on the configurations of prospective commercial transports and military airlifters, SSTs, and HSTs, as well as to the use of the plentiful heatsink capacity of LH2 for innovative propulsion cycles' performance maximization. State-of-the-art materials and structural design principles for integral cryotank implementation are noted, as are airport requirements and safety and environmental considerations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edgar, Thomas W.; Hadley, Mark D.; Manz, David O.

This document provides the methods to secure routable control system communication in the electric sector. The approach of this document yields a long-term vision for a future of secure communication, while also providing near term steps and a roadmap. The requirements for the future secure control system environment were spelled out to provide a final target. Additionally a survey and evaluation of current protocols was used to determine if any existing technology could achieve this goal. In the end a four-step path was described that brought about increasing requirement completion and culminates in the realization of the long term vision.

Draft Plan to Develop Non-Intrusive Load Monitoring Test Protocols

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayhorn, Ebony T.; Sullivan, Greg P.; Petersen, Joseph M.

2015-09-29

This document presents a Draft Plan proposed to develop a common test protocol that can be used to evaluate the performance requirements of Non-Intrusive Load Monitoring. Development on the test protocol will be focused on providing a consistent method that can be used to quantify and compare the performance characteristics of NILM products. Elements of the protocols include specifications for appliances to be used, metrics, instrumentation, and a procedure to simulate appliance behavior during tests. In addition, three priority use cases for NILM will be identified and their performance requirements will specified.

Community Schools in Ohio: Implementation Issues and Impact on Ohio's Education System. Volume I.

ERIC Educational Resources Information Center

Ohio State Legislative Office of Education Oversight, Columbus.

Community schools were created in Ohio to provide additional educational options for children in low-performing schools and to develop innovative teaching and management techniques that may be transferable to traditional public schools. In 1997 the Ohio General Assembly required the Legislative Office of Education Oversight (LOEO) to evaluate the…

36 CFR 1236.28 - What additional requirements apply to the selection and maintenance of electronic records storage...

Code of Federal Regulations, 2010 CFR

2010-07-01

... storage libraries and test or evaluation areas that contain permanent or unscheduled records must be smoke... the National Institute of Standards and Technology (NIST) Special Publication 500-252, Care and... to discover and correct the causes of data loss. In magnetic computer tape libraries with 1800 or...

76 FR 4584 - Approval and Promulgation of Air Quality Implementation Plans; Georgia; Disapproval of Interstate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... conclusion must be supported by an adequate technical analysis. Second, EPA recommended the various types of... requirement of section 110(a)(2)(D)(i)(I) must be supported by an adequate technical analysis. Additionally... evaluate or demonstrate with a technical analysis that this measure and their intention to rely to the...

Improving K-12 Online Learning: Information Literacy Skills for Teacher Candidates

ERIC Educational Resources Information Center

Ntuli, Esther; Kyei-Blankson, Lydia

2016-01-01

Research indicates the need for teachers to be able to locate, evaluate, and use Internet resources in their teaching and learning processes. In addition, the Common Core State Standards require that students are able to think critically and know how to search and use alternative views and perspectives in their assignments. These skills are…

76 FR 38937 - World Trade Center Health Program Requirements for the Addition of New WTC-Related Health Conditions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... following methods: Internet: Access the Federal e-rulemaking portal at http://www.regulations.gov . Follow... initial health evaluations, diagnostic and treatment services for residents, students, and others in the... rulemaking and the public will have the opportunity to consider and comment on the review methods applied in...

Suitability of School Textbooks for 5 to 7 Year Old Children with Colour Vision Deficiencies

ERIC Educational Resources Information Center

Torrents, Aurora; Bofill, Francesc; Cardona, Genis

2011-01-01

Purpose: The aim of the present study was to determine, through colorimetric analysis, whether school textbooks for children aged 5 to 7 years contained tasks requiring normal colour vision discrimination for their resolution. In addition, the performance of a group of observers with diverse colour vision deficiencies was evaluated while…

Live Action Role Play and the Development of Teacher Competences: Evaluation of "Everyday Life in the Classroom"

ERIC Educational Resources Information Center

Imhof, Margarete; Starker, Ulrike; Spaude, Elena

2016-01-01

Building on Dörner's (1996) theory of complex problem-solving, a learning scenario for teacher students was created and tested. Classroom management is interpreted as a complex problem, which requires the integration of competing interests and tackling multiple, simultaneous tasks under time pressure and with limited information. In addition,…

Hazardous materials responses in a mid-sized metropolitan area.

PubMed

Walter, Frank G; Bates, Gerry; Criss, Elizabeth A; Bey, Tareg; Spaite, Daniel W; Valenzuela, Terence

2003-01-01

To determine the chemicals involved in fire department hazardous materials (hazmat) responses and analyze the concomitant emergency medical services' patient care needs. The setting was a mid-sized metropolitan area in the southwestern United States with a population base of 400,000 and an incorporated area of 165 square miles. The authors conducted a retrospective evaluation of all fire department hazmat reports, with associated emergency medical services patient encounter forms, and in-patient hospital records from January 1, 1992, through December 31, 1994. The fire department hazardous materials control team responded to 468 hazmat incidents, involving 62 chemicals. The majority of incidents occurred on city streets, with a mean incident duration of 46 minutes. More than 70% of the responses involved flammable gases or liquids. A total of 32 incidents generated 85 patients, 53% of whom required transport for further evaluation and care. Most patients were exposed to airborne toxicants. Only two patients required hospital admission for carbon monoxide poisoning. Most hazmat incidents result in few exposed patients who require emergency medical services care. Most patients were exposed to airborne toxicants and very few required hospitalization. Routine data analysis such as this provides emergency response personnel with the opportunity to evaluate current emergency plans and identify areas where additional training may be necessary.

Ultrasonic assessment of additive manufactured Ti-6Al-4V

NASA Astrophysics Data System (ADS)

Schehl, Norman; Kramb, Vicki; Dierken, Josiah; Aldrin, John; Schwalbach, Edwin; John, Reji

2018-04-01

Additive Manufacturing (AM) processes offer the potential for manufacturing cost savings and rapid insertion into service through production of near net shape components for complicated structures. Use of these parts in high reliability applications such as those in the aerospace industry will require nondestructive characterization methods to ensure post-process material quality in as-built condition. Ultrasonic methods can be used for this quality verification. Depending on the application, the service life of AM components can be sensitive to the part surface condition. The surface roughness and layered structure inherent to the electron-beam powder-bed fusion process necessitates new approaches to evaluate subsurface material integrity in its presence. Experimental methods and data analytics may improve the evaluation of as-built additively manufactured materials. This paper discusses the assessment of additively manufactured EBM Ti-6Al-4V panels using ultrasonic methods and the data analytics applied to evaluate material integrity. The assessment was done as an exploratory study as the discontinuities of interest in these test samples were not known when the measurements were performed. Water immersion ultrasonic techniques, including pulse-echo and through transmission with 10 MHz focused transducers, were used to explore the material integrity of as-built plates. Subsequent destructive mechanical tests of specimens extracted from the plates provided fracture locations indicating critical flaws. To further understand the effect of surface-roughness, an evaluation of ultrasonic response in the presence of as-built surfaces and with the surface removed was performed. The assessment of additive manufactured EBM Ti-6Al-4V panels with ultrasonic techniques indicated that ultrasonic energy was attenuated by the as-built surface roughness. In addition, feature detection was shown to be sensitive to experimental ultrasonic parameters and flaw morphology.

Antifibrinolytic agents and desmopressin as hemostatic agents in cardiac surgery.

PubMed

Erstad, B L

2001-09-01

To review the use of systemic hemostatic medications for reducing bleeding and transfusion requirements with cardiac surgery. Articles were obtained through computerized searches involving MEDLINE (from 1966 to September 2000). Additionally, several textbooks containing information on the diagnosis and management of bleeding associated with cardiac surgery were reviewed. The bibliographies of retrieved publications and textbooks were reviewed for additional references. Due to the large number of randomized investigations involving systemic hemostatic medications for reducing bleeding associated with cardiac surgery, the article selection process focused on recent randomized controlled trials, metaanalyses and pharmacoeconomic evaluations. The primary outcomes extracted from the literature were blood loss and associated transfusion requirements, although other outcome measures such as mortality were extracted when available. Although the majority of investigations for reducing cardiac bleeding and transfusion requirements have involved aprotinin, evidence from recent meta-analyses and randomized trials indicates that the synthetic antifibrinolytic agents, aminocaproic acid and tranexamic acid, have similar clinical efficacy. Additionally, aminocaproic acid (and to a lesser extent tranexamic acid) is much less costly. More comparative information of hemostatic agents is needed retative to other outcomes (eg., reoperation rates, myocardial infarction, stroke). There is insufficient evidence to recommend the use of desmopressin for reducing bleeding and transfusion requirements in cardiac surgery, although certain subsets of patients may benefit from its use. Of the medications that have been used to reduce bleeding and transfusion requirements with cardiac surgery, the antifibrinolytic agents have the best evidence supporting their use. Aminocaproic acid is the least costly therapy based on medication costs and transfusion requirements.

Performance of small cluster surveys and the clustered LQAS design to estimate local-level vaccination coverage in Mali

PubMed Central

2012-01-01

Background Estimation of vaccination coverage at the local level is essential to identify communities that may require additional support. Cluster surveys can be used in resource-poor settings, when population figures are inaccurate. To be feasible, cluster samples need to be small, without losing robustness of results. The clustered LQAS (CLQAS) approach has been proposed as an alternative, as smaller sample sizes are required. Methods We explored (i) the efficiency of cluster surveys of decreasing sample size through bootstrapping analysis and (ii) the performance of CLQAS under three alternative sampling plans to classify local VC, using data from a survey carried out in Mali after mass vaccination against meningococcal meningitis group A. Results VC estimates provided by a 10 × 15 cluster survey design were reasonably robust. We used them to classify health areas in three categories and guide mop-up activities: i) health areas not requiring supplemental activities; ii) health areas requiring additional vaccination; iii) health areas requiring further evaluation. As sample size decreased (from 10 × 15 to 10 × 3), standard error of VC and ICC estimates were increasingly unstable. Results of CLQAS simulations were not accurate for most health areas, with an overall risk of misclassification greater than 0.25 in one health area out of three. It was greater than 0.50 in one health area out of two under two of the three sampling plans. Conclusions Small sample cluster surveys (10 × 15) are acceptably robust for classification of VC at local level. We do not recommend the CLQAS method as currently formulated for evaluating vaccination programmes. PMID:23057445

[Ultrasound guided percutaneous nephrolithotripsy].

PubMed

Guliev, B G

2014-01-01

The study was aimed to the evaluation of the effectiveness and results of ultrasound guided percutaneous nephrolithotripsy (PNL) for the treatment of patients with large stones in renal pelvis. The results of PNL in 138 patients who underwent surgery for kidney stones from 2011 to 2013 were analyzed. Seventy patients (Group 1) underwent surgery with combined ultrasound and radiological guidance, and 68 patients (Group 2)--only with ultrasound guidance. The study included patients with large renal pelvic stones larger than 2.2 cm, requiring the formation of a single laparoscopic approach. Using the comparative analysis, the timing of surgery, the number of intra- and postoperative complications, blood loss and length of stay were evaluated. Percutaneous access was successfully performed in all patients. Postoperative complications (exacerbation of chronic pyelonephritis, gross hematuria) were observed in 14.3% of patients in Group 1 and in 14.7% of patients in Group 2. Bleeding requiring blood transfusion, and injuries of adjacent organs were not registered. Efficacy of PNL in the Group 1 was 95.7%; 3 (4.3%) patients required additional interventions. In Group 2, the effectiveness of PNL was 94.1%, 4 (5.9%) patients additionally underwent extracorporeal lithotripsy. There were no significant differences in the effectiveness of PNL, the volume of blood loss and duration of hospitalization. Ultrasound guided PNL can be performed in large pelvic stones and sufficient expansion of renal cavities, thus reducing radiation exposure of patients and medical staff.

Qualification of Daiichi Units 1, 2, and 3 Data for Severe Accident Evaluations - Process and Illustrative Examples from Prior TMI-2 Evaluations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rempe, Joy Lynn; Knudson, Darrell Lee

2014-09-01

The accidents at the Three Mile Island Unit 2 (TMI-2) Pressurized Water Reactor (PWR) and the Daiichi Units 1, 2, and 3 Boiling Water Reactors (BWRs) provide unique opportunities to evaluate instrumentation exposed to severe accident conditions. Conditions associated with the release of coolant and the hydrogen burn that occurred during the TMI-2 accident exposed instrumentation to harsh conditions, including direct radiation, radioactive contamination, and high humidity with elevated temperatures and pressures. As part of a program initiated in 2012 by the Department of Energy Office of Nuclear Energy (DOE-NE), a review was completed to gain insights from prior TMI-2more » sensor survivability and data qualification efforts. This initial review focused on the set of sensors deemed most important by post-TMI-2 instrumentation evaluation programs. Instrumentation evaluation programs focused on data required by TMI-2 operators to assess the condition of the reactor and containment and the effect of mitigating actions taken by these operators. In addition, prior efforts focused on sensors providing data required for subsequent forensic evaluations and accident simulations. To encourage the potential for similar activities to be completed for qualifying data from Daiichi Units 1, 2, and 3, this report provides additional details related to the formal process used to develop a qualified TMI-2 data base and presents data qualification details for three parameters: primary system pressure; containment building temperature; and containment pressure. As described within this report, sensor evaluations and data qualification required implementation of various processes, including comparisons with data from other sensors, analytical calculations, laboratory testing, and comparisons with sensors subjected to similar conditions in large-scale integral tests and with sensors that were similar in design to instruments easily removed from the TMI-2 plant for evaluations. As documented in this report, results from qualifying data for these parameters led to key insights related to TMI-2 accident progression. Hence, these selected examples illustrate the types of activities completed in the TMI-2 data qualification process and the importance of such a qualification effort. These details are documented in this report to facilitate implementation of similar process using data and examinations at the Daiichi Units 1, 2, and 3 reactors so that BWR-specific benefits can be obtained.« less

A results-based process for evaluation of diverse visual analytics tools

NASA Astrophysics Data System (ADS)

Rubin, Gary; Berger, David H.

2013-05-01

With the pervasiveness of still and full-motion imagery in commercial and military applications, the need to ingest and analyze these media has grown rapidly in recent years. Additionally, video hosting and live camera websites provide a near real-time view of our changing world with unprecedented spatial coverage. To take advantage of these controlled and crowd-sourced opportunities, sophisticated visual analytics (VA) tools are required to accurately and efficiently convert raw imagery into usable information. Whether investing in VA products or evaluating algorithms for potential development, it is important for stakeholders to understand the capabilities and limitations of visual analytics tools. Visual analytics algorithms are being applied to problems related to Intelligence, Surveillance, and Reconnaissance (ISR), facility security, and public safety monitoring, to name a few. The diversity of requirements means that a onesize- fits-all approach to performance assessment will not work. We present a process for evaluating the efficacy of algorithms in real-world conditions, thereby allowing users and developers of video analytics software to understand software capabilities and identify potential shortcomings. The results-based approach described in this paper uses an analysis of end-user requirements and Concept of Operations (CONOPS) to define Measures of Effectiveness (MOEs), test data requirements, and evaluation strategies. We define metrics that individually do not fully characterize a system, but when used together, are a powerful way to reveal both strengths and weaknesses. We provide examples of data products, such as heatmaps, performance maps, detection timelines, and rank-based probability-of-detection curves.

Implementation of a fully-balanced periodic tridiagonal solver on a parallel distributed memory architecture

NASA Technical Reports Server (NTRS)

Eidson, T. M.; Erlebacher, G.

1994-01-01

While parallel computers offer significant computational performance, it is generally necessary to evaluate several programming strategies. Two programming strategies for a fairly common problem - a periodic tridiagonal solver - are developed and evaluated. Simple model calculations as well as timing results are presented to evaluate the various strategies. The particular tridiagonal solver evaluated is used in many computational fluid dynamic simulation codes. The feature that makes this algorithm unique is that these simulation codes usually require simultaneous solutions for multiple right-hand-sides (RHS) of the system of equations. Each RHS solutions is independent and thus can be computed in parallel. Thus a Gaussian elimination type algorithm can be used in a parallel computation and the more complicated approaches such as cyclic reduction are not required. The two strategies are a transpose strategy and a distributed solver strategy. For the transpose strategy, the data is moved so that a subset of all the RHS problems is solved on each of the several processors. This usually requires significant data movement between processor memories across a network. The second strategy attempts to have the algorithm allow the data across processor boundaries in a chained manner. This usually requires significantly less data movement. An approach to accomplish this second strategy in a near-perfect load-balanced manner is developed. In addition, an algorithm will be shown to directly transform a sequential Gaussian elimination type algorithm into the parallel chained, load-balanced algorithm.

Scandinavian Total Ankle Replacement: 15-Year Follow-up.

PubMed

Palanca, Ariel; Mann, Roger A; Mann, Jeffrey A; Haskell, Andrew

2018-02-01

Over the past decade, total ankle arthroplasty (TAA) has become a mainstay in the treatment of end-stage ankle arthritis. Currently in its fourth generation, the Scandanavian Total Ankle Replacement (STAR) is the only 3-piece mobile bearing ankle prosthesis available in the United States. Our current study reports implant survivorship at 15 years and patient outcomes for a subset of these survivors available for study. Eighty-four TAAs were performed between 1998 and 2000. Metal component survivorship at 15 years was calculated with a Kaplan-Meier curve. Twenty-four (29%) of 84 patients were available for participation with a minimum 15-year follow-up. Any radiographic changes were documented. All additional procedures and complications were recorded. Clinical findings, self-reported performance and pain evaluations, and AOFAS ankle/hindfoot scores were noted. Metal implant survival was 73% at 15 years. Of the 24 patients available for clinical evaluation, 18 of 24 patients (70.7%) had no change in prosthetic alignment from the immediate postoperative radiograph. Only 1 subtalar fusion was required for symptomatic adjacent joint arthritis. Three patients sustained a broken polyethylene component. AOFAS scores improved from an average of 39.6 points preoperatively, to an average of 71.6. More than half (52.4%) of patients with retained implants required an additional surgical procedure; 3 required 2 additional procedures. The average time to subsequent procedure was 10.2 years. Our small cohort demonstrated STAR ankles with retention at 9 years were highly likely to survive to 15 years, and patients continued to have significant improvement in pain relief and minimal decrease in function. At 15 years from TAA, metal survivorship was 73%. As with all ankle replacements, supplementary procedures were common. Level IV, case series.

Contamination avoidance devices for poppet type shutoff valves

NASA Technical Reports Server (NTRS)

Endicott, D. L.

1972-01-01

The technology required to provide acceptable contamination damage avoidance characteristics for poppet type shutoff valves is discussed. Evaluation of the contamination avoidance characteristics of the basic 1T32095 propellant shutoff valve, the cycle life performance of these valves in an uncontaminated environment, and the effectiveness of various auxiliary contamination avoidance devices when used in conjunction with these poppet type valves are included. In addition, a secondary objective is to evaluate two methods of monitoring the performance of the test valves during actual operations using acoustical monitoring instrumentation.

Cockpit design and evaluation using interactive graphics

NASA Technical Reports Server (NTRS)

Evans, S. M.

1975-01-01

A general overview of the characteristics of an interactive graphics system which was developed to assist cockpit engineers design and evaluate work stations was presented. The manikin used in this COMputerized BIomechanical MAN-model (COMBIMAN) was described, as are provisions for generating work stations and assessing interactions between man and environment. The applications of the present system are explained, and critiques of COMBIMAN are presented. The limitations of the existing programs and the requirements of the designers necessitate future revisions and additions to the biomechanical and erogonomic properties of COMBIMAN. Some of these enhancements are discussed.

New atmospheric sensor analysis study

NASA Technical Reports Server (NTRS)

Parker, K. G.

1989-01-01

The functional capabilities of the ESAD Research Computing Facility are discussed. The system is used in processing atmospheric measurements which are used in the evaluation of sensor performance, conducting design-concept simulation studies, and also in modeling the physical and dynamical nature of atmospheric processes. The results may then be evaluated to furnish inputs into the final design specifications for new space sensors intended for future Spacelab, Space Station, and free-flying missions. In addition, data gathered from these missions may subsequently be analyzed to provide better understanding of requirements for numerical modeling of atmospheric phenomena.

Evaluation of OMNIgene®•SPUTUM for tuberculosis sample processing and liquid culture at a hospital laboratory in India.

PubMed

Nambiar, Remya; Shaw, Kaitlyn; Curry, Patricia S

2017-10-01

This preliminary evaluation examined the reagent OMNIgene®•SPUTUM (OM-S) as a tool to eliminate NaOH/NALC processing prior to Middlebrook liquid culture for Mycobacterium tuberculosis (MTb). Twenty-seven manually split samples (OM-S-treated vs. NaOH/NALC) showed 100% agreement: 81.5% MTb-positive and 18.5% MTb-negative. On average, OM-S-treated specimens required 1.2 additional days to culture positivity. Copyright © 2017 Elsevier B.V. All rights reserved.

Food Service and Nutrition for the Space Station

NASA Technical Reports Server (NTRS)

Sauer, R. L. (Editor)

1985-01-01

The proceedings of the Workshop on Food Service and Nutrition for the Space Station, held in Houston, Texas, on April 10 and 11, 1984 was given. The workshop was attended by experts in food technology from industry, government, and academia. Following a general definition of unique space flight requirements, oral presentations were made on state of the art food technology with the objective of using this technology to support the space flight requirements. Numerous areas are identified which in the opinion of the conferees, would have space flight application. But additional effort, evaluation, or testing to include Shuttle inflight testing will be required for the technology to be applied to the Space Station.

Cost analysis of oxygen recovery systems

NASA Technical Reports Server (NTRS)

Yakut, M. M.

1973-01-01

Report is made of the cost analysis of four leading oxygen recovery subsystems which include two carbon dioxide reduction subsystems and two water electrolysis subsystems, namely, the solid polymer electrolyte and the circulating KOH electrolyte. The four oxygen recovery systems were quantitatively evaluated. System characteristics, including process flows, performance, and physical characteristics were also analyzed. Additionally, the status of development of each of the systems considered and the required advance technology efforts required to bring conceptual and/or pre-prototype hardware to an operational prototype status were defined. Intimate knowledge of the operations, development status, and capabilities of the systems to meet space mission requirements were found to be essential in establishing the cost estimating relationships for advanced life support systems.

Novel excipients - Regulatory challenges and perspectives - The EU insight.

PubMed

Kozarewicz, Piotr; Loftsson, Thorsteinn

2018-05-21

Novel excipients are indispensable in development of modern, advanced drug delivery systems and biotechnology-derived drugs. Although numerous novel excipients are developed for pharmaceutical use, they are not frequently seen in medicinal products due to the strict regulatory requirements and perception that their use makes new product evaluation more complex with risk of delays in the approval process. Regulators regard novel excipients as new substances and whenever new excipient is used in a formulation it must be subjected to full evaluation, similarly to the one required for new active substance. Consequently, the amount of information required in support of the regulatory approval (i.e. marketing authorization) is much more complex and comprehensive than for established excipients. This short review provides an insight into the use of novel excipients in medicinal products approved in the European Union. In addition, barriers and challenges in development of novel excipients are being discussed as well as means to overcome those barriers. Copyright © 2018 Elsevier B.V. All rights reserved.

The Future Impact of Wind on BPA Power System Ancillary Services

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makarov, Yuri V.; Lu, Shuai; McManus, Bart

Wind power is growing in a very fast pace as an alternative generating resource. As the ratio of wind power over total system capacity increases, the impact of wind on various system aspects becomes significant. This paper presents a methodology to study the future impact of wind on BPA power system ancillary services including load following and regulation. Existing approaches for similar analysis include dispatch model simulation and standard deviation evaluation. The methodology proposed in this paper uses historical data and stochastic processes to simulate the load balancing processes in BPA power system. Then capacity, ramp rate and ramp durationmore » characteristics are extracted from the simulation results, and load following and regulation requirements are calculated accordingly. It mimics the actual power system operations therefore the results can be more realistic yet the approach is convenient to perform. Further, the ramp rate and ramp duration data obtained from the analysis can be used to evaluate generator response or maneuverability and energy requirement, respectively, additional to the capacity requirement.« less

Virtual Laboratories to Achieve Higher-Order Learning in Fluid Mechanics

NASA Astrophysics Data System (ADS)

Ward, A. S.; Gooseff, M. N.; Toto, R.

2009-12-01

Bloom’s higher-order cognitive skills (analysis, evaluation, and synthesis) are recognized as necessary in engineering education, yet these are difficult to achieve in traditional lecture formats. Laboratory components supplement traditional lectures in an effort to emphasize active learning and provide higher-order challenges, but these laboratories are often subject to the constraints of (a) increasing student enrollment, (b) limited funding for operational, maintenance, and instructional expenses and (c) increasing demands on undergraduate student credit requirements. Here, we present results from a pilot project implementing virtual (or online) laboratory experiences as an alternative to a traditional laboratory experience in Fluid Mechanics, a required third year course. Students and faculty were surveyed to identify the topics that were most difficult, and virtual laboratory and design components developed to supplement lecture material. Each laboratory includes a traditional lab component, requiring student analysis and evaluation. The lab concludes with a design exercise, which imposes additional problem constraints and allows students to apply their laboratory observations to a real-world situation.

State-of-the-Art Review of Echocardiographic Imaging in the Evaluation and Treatment of Functional Tricuspid Regurgitation.

PubMed

Hahn, Rebecca T

2016-12-01

Functional or secondary tricuspid regurgitation (TR) is the most common cause of severe TR in the Western world. The presence of functional TR, either isolated or in combination with left heart disease, is associated with unfavorable natural history. Surgical mortality for isolated tricuspid valve interventions remains higher than for any other single valve surgery, and surgical options for repair do not have consistent long-term durability. In addition, as more patients undergo transcatheter left valve interventions, developing transcatheter solutions for functional TR has gained greater momentum. Numerous transcatheter devices are currently in early clinical trials. All patients require an assessment of valve morphology and function, and transcatheter devices typically require intraprocedural guidance by echocardiography. The following review will describe tricuspid anatomy, define echocardiographic views for evaluating tricuspid valve morphology and function, and discuss imaging requirements for the current transcatheter devices under development for the treatment of functional TR. © 2016 American Heart Association, Inc.

Lipid metabolism-related gene expression pattern of Atlantic bluefin tuna (Thunnus thynnus L.) larvae fed on live prey.

PubMed

Betancor, Mónica B; Ortega, Aurelio; de la Gándara, Fernando; Tocher, Douglas R; Mourente, Gabriel

2017-04-01

The present study is the first to evaluate lipid metabolism in first-feeding Atlantic bluefin tuna (ABT; Thunnus thynnus L.) larvae fed different live prey including enriched rotifers Brachionus plicatilis and Acartia sp. copepod nauplii from 2 days after hatch. Understanding the molecular basis of lipid metabolism and regulation in ABT will provide insights to optimize diet formulations for this high-value species new to aquaculture. To this end, we investigated the effect of dietary lipid on whole larvae lipid class and fatty acid compositions and the expression of key genes involved in lipid metabolism in first feeding ABT larvae fed different live prey. Additionally, the expression of lipid metabolism genes in tissues of adult broodstock ABT was evaluated. Growth and survival data indicated that copepods were the best live prey for first feeding ABT and that differences in growth performance and lipid metabolism observed between larvae from different year classes could be a consequence of broodstock nutrition. In addition, expression patterns of lipid metabolic genes observed in ABT larvae in the trials could reflect differences in lipid class and fatty acid compositions of the live prey. The lipid nutritional requirements, including essential fatty acid requirements of larval ABT during the early feeding stages, are unknown, and the present study represents a first step in addressing these highly relevant issues. However, further studies are required to determine nutritional requirements and understand lipid metabolism during development of ABT larvae and to apply the knowledge to the commercial culture of this iconic species.

Development and qualification of additively manufactured parts for space

NASA Astrophysics Data System (ADS)

O'Brien, Michael J.

2018-02-01

Additive manufacturing (commonly called "3D printing") fabricates the desired final part directly from the input CAD (Computer Aided Design) file by depositing and fusing layer upon layer of the source material. New engineering designs are possible in which a single optimized part with novel topology can replace several traditional parts. The complex physics of metal deposition leads to variations in quality and to new flaws and residual stresses not seen in traditional manufacturing. Additive manufacturing currently has gaps in knowledge. Mission assurance will require: qualification and certification standards; sharing of data in handbooks; predictive models relating processing, microstructure and properties; and development of closed loop process control and non-destructive evaluation to reduce variability.

Matrix effect and correction by standard addition in quantitative liquid chromatographic-mass spectrometric analysis of diarrhetic shellfish poisoning toxins.

PubMed

Ito, Shinya; Tsukada, Katsuo

2002-01-11

An evaluation of the feasibility of liquid chromatography-mass spectrometry (LC-MS) with atmospheric pressure ionization was made for quantitation of four diarrhetic shellfish poisoning toxins, okadaic acid, dinophysistoxin-1, pectenotoxin-6 and yessotoxin in scallops. When LC-MS was applied to the analysis of scallop extracts, large signal suppressions were observed due to coeluting substances from the column. To compensate for these matrix signal suppressions, the standard addition method was applied. First, the sample was analyzed and then the sample involving the addition of calibration standards is analyzed. Although this method requires two LC-MS runs per analysis, effective correction of quantitative errors was found.

Anticipating implementation of colorectal cancer screening in The Netherlands: a nation wide survey on endoscopic supply and demand

PubMed Central

2012-01-01

Background Colorectal cancer (CRC) screening requires sufficient endoscopic resources. The present study aims to determine the Dutch endoscopic production and manpower for 2009, evaluate trends since 2004, determine additional workload which would be caused by implementation of a CRC screening program, and inventory colonoscopy rates performed in other European countries. Methods All Dutch endoscopy units (N = 101) were surveyed for manpower and the numbers of endoscopy procedures performed in 2009. Based on calculations in the report issued by the Dutch Health Council, future additional workload caused by faecal immunochemical test (FIT) screening was estimated. The number of colonoscopies performed in Europe was evaluated by a literature search and an email-inquiry. Results Compared to 2004, there was a 24% increase in total endoscopies (N = 505,226 in 2009), and a 64% increase in colonoscopies (N = 191,339 in 2009) in The Netherlands. The number of endoscopists had increased by 4.6% (N = 583 in 2009). Five years after stepwise implementation of FIT-based CRC screening, endoscopic capacity needs to be increased an additional 15%. A lack of published data on the number of endoscopies performed in Europe was found. Based on our email-inquiry, the number of colonoscopies per 100,000 inhabitants ranged from 126 to 3,031 in 15 European countries. Conclusions Over the last years, endoscopic procedures increased markedly in The Netherlands without a corresponding increase in manpower. A FIT-based CRC screening program requires an estimated additional 15% increase in endoscopic procedures. It is very likely that current colonoscopy density varies widely across European countries. PMID:22280408

Active-learning assignments to integrate basic science and clinical course material.

PubMed

Marshall, Leisa L; Nykamp, Diane

2010-09-10

To develop, implement, and evaluate active-learning exercises requiring the integration and application of pathophysiology, medicinal chemistry, pharmacology, and therapeutics knowledge of osteoarthritis and rheumatoid arthritis to formulate therapeutic recommendations for patients with musculoskeletal disorders. Two team-based case study exercises, one evaluating a patient with osteoarthritis and the second, a patient with rheumatoid arthritis, were developed, incorporating material and questions from pathophysiology, medicinal chemistry, pharmacology, and therapeutics. The learning assignments were implemented in a required pharmacotherapy module. Student learning was evaluated using performance on the team-based case study exercises and on 2 examinations. A standard student course evaluation was used to assess students' impressions of the learning activity. The mean student grades for the osteoarthritis and rheumatoid arthritis activities were 9.1 and 8.9, respectively, on a 10-point scale. The majority of students indicated that the learning exercises were more than adequate to excellent in helping students learn. The addition of active-learning activities was successful in teaching pharmacy students the knowledge needed to formulate therapeutic recommendations for patients with musculoskeletal disorders.

Discontinuous Spectral Difference Method for Conservation Laws on Unstructured Grids

NASA Technical Reports Server (NTRS)

Liu, Yen; Vinokur, Marcel

2004-01-01

A new, high-order, conservative, and efficient discontinuous spectral finite difference (SD) method for conservation laws on unstructured grids is developed. The concept of discontinuous and high-order local representations to achieve conservation and high accuracy is utilized in a manner similar to the Discontinuous Galerkin (DG) and the Spectral Volume (SV) methods, but while these methods are based on the integrated forms of the equations, the new method is based on the differential form to attain a simpler formulation and higher efficiency. Conventional unstructured finite-difference and finite-volume methods require data reconstruction based on the least-squares formulation using neighboring point or cell data. Since each unknown employs a different stencil, one must repeat the least-squares inversion for every point or cell at each time step, or to store the inversion coefficients. In a high-order, three-dimensional computation, the former would involve impractically large CPU time, while for the latter the memory requirement becomes prohibitive. In addition, the finite-difference method does not satisfy the integral conservation in general. By contrast, the DG and SV methods employ a local, universal reconstruction of a given order of accuracy in each cell in terms of internally defined conservative unknowns. Since the solution is discontinuous across cell boundaries, a Riemann solver is necessary to evaluate boundary flux terms and maintain conservation. In the DG method, a Galerkin finite-element method is employed to update the nodal unknowns within each cell. This requires the inversion of a mass matrix, and the use of quadratures of twice the order of accuracy of the reconstruction to evaluate the surface integrals and additional volume integrals for nonlinear flux functions. In the SV method, the integral conservation law is used to update volume averages over subcells defined by a geometrically similar partition of each grid cell. As the order of accuracy increases, the partitioning for 3D requires the introduction of a large number of parameters, whose optimization to achieve convergence becomes increasingly more difficult. Also, the number of interior facets required to subdivide non-planar faces, and the additional increase in the number of quadrature points for each facet, increases the computational cost greatly.

Flexible Foam Protection Materials for Constellation Space Suit Element Portable Life Support Subsystem Packaging Study

NASA Technical Reports Server (NTRS)

Tang, Henry H.; Orndoff, Evelyne S.; Thomas, Gretchen A.

2009-01-01

This paper discusses the effort in evaluating and selecting a light weight impact protection material for the Constellation Space Suit Element (CSSE) Portable Life Support Subsystem (PLSS) conceptual packaging study. A light weight material capable of holding and protecting the components inside the PLSS is required to demonstrate the viability of the flexible PLSS packaging concept. The material needs to distribute, dissipate, and absorb the impact energy of the PLSS falling on the lunar surface. It must also be very robust and function in the extreme lunar thermal vacuum environment for up to one hundred Extravehicular Activity (EVA) missions. This paper documents the performance requirements for selecting a foam protection material, and the methodologies for evaluating commercial off-the-shelf (COTS) foam protection materials. It also presents the materials properties test results and impact drop test results of the various foam materials evaluated in the study. The findings from this study suggest that a foam based flexible protection system is a viable solution for PLSS packaging. However, additional works are needed to optimize COTS foam properties or to develop a composite foam system that will meet all the performance requirements for the CSSE PLSS flexible packaging.

A Multimodal Deep Log-Based User Experience (UX) Platform for UX Evaluation

PubMed Central

Ali Khan, Wajahat; Hur, Taeho; Muhammad Bilal, Hafiz Syed; Ul Hassan, Anees; Lee, Sungyoung

2018-01-01

The user experience (UX) is an emerging field in user research and design, and the development of UX evaluation methods presents a challenge for both researchers and practitioners. Different UX evaluation methods have been developed to extract accurate UX data. Among UX evaluation methods, the mixed-method approach of triangulation has gained importance. It provides more accurate and precise information about the user while interacting with the product. However, this approach requires skilled UX researchers and developers to integrate multiple devices, synchronize them, analyze the data, and ultimately produce an informed decision. In this paper, a method and system for measuring the overall UX over time using a triangulation method are proposed. The proposed platform incorporates observational and physiological measurements in addition to traditional ones. The platform reduces the subjective bias and validates the user’s perceptions, which are measured by different sensors through objectification of the subjective nature of the user in the UX assessment. The platform additionally offers plug-and-play support for different devices and powerful analytics for obtaining insight on the UX in terms of multiple participants. PMID:29783712

A Multimodal Deep Log-Based User Experience (UX) Platform for UX Evaluation.

PubMed

Hussain, Jamil; Khan, Wajahat Ali; Hur, Taeho; Bilal, Hafiz Syed Muhammad; Bang, Jaehun; Hassan, Anees Ul; Afzal, Muhammad; Lee, Sungyoung

2018-05-18

The user experience (UX) is an emerging field in user research and design, and the development of UX evaluation methods presents a challenge for both researchers and practitioners. Different UX evaluation methods have been developed to extract accurate UX data. Among UX evaluation methods, the mixed-method approach of triangulation has gained importance. It provides more accurate and precise information about the user while interacting with the product. However, this approach requires skilled UX researchers and developers to integrate multiple devices, synchronize them, analyze the data, and ultimately produce an informed decision. In this paper, a method and system for measuring the overall UX over time using a triangulation method are proposed. The proposed platform incorporates observational and physiological measurements in addition to traditional ones. The platform reduces the subjective bias and validates the user's perceptions, which are measured by different sensors through objectification of the subjective nature of the user in the UX assessment. The platform additionally offers plug-and-play support for different devices and powerful analytics for obtaining insight on the UX in terms of multiple participants.

Reconstruction of the maxilla following hemimaxillectomy defects with scapular tip grafts and dental implants.

PubMed

Mertens, Christian; Freudlsperger, Christian; Bodem, Jens; Engel, Michael; Hoffmann, Jürgen; Freier, Kolja

2016-11-01

Treatment of post-resective defects of the maxilla can be challenging and usually requires dental obturation or microvascular reconstruction. As compared to soft-tissue microvascular grafts, bone reconstruction can additionally allow for facial support and retention of dental implants. The aim of this study was to evaluate scapular tip grafts with respect to their applicability for maxillary reconstruction and their potential to retain dental implants for later dental rehabilitation. In this retrospective study, 14 patients with hemimaxillectomy defects were reconstructed with free scapular tip grafts, oriented horizontally, to rebuild the palate and alveolar ridge. After bone healing, three-dimensional virtual implant planning was performed, and a radiographic guide was fabricated to enable implant placement in the optimal anatomic and prosthetic position. All patients' mastication and speech were evaluated, along with the extent of defect closure, suitability of the graft sites for implant placement, and soft-tissue stability. Pre- and postsurgical radiographs were also evaluated. A good postoperative outcome was achieved in all patients, with complete closure of maxillary defects that were class II, according to the system of Brown and Shaw. Additional bone augmentation was necessary in two patients in order to increase vertical bone height. Patients were subsequently treated with 50 dental implants to retain dental prostheses. In all cases, additional soft-tissue surgery was necessary to achieve a long-term stable periimplant situation. No implants were lost during the mean observation period of 34 months. Due to its specific form, the scapular tip graft is well suited to reconstruct the palate and maxillary alveolar ridge and to enable subsequent implant-retained rehabilitation. Due to the limited bone volume, an accurate three-dimensional graft orientation is essential. Furthermore, most cases require additional soft-tissue surgery to achieve a long-term stable periimplant situation. Copyright © 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Current and future methods for evaluating the allergenic potential of proteins: international workshop report 23-25 October 2007.

PubMed

Thomas, Karluss; Herouet-Guicheney, Corinne; Ladics, Gregory; McClain, Scott; MacIntosh, Susan; Privalle, Laura; Woolhiser, Mike

2008-09-01

The International Life Science Institute's Health and Environmental Sciences Institute's Protein Allergenicity Technical Committee hosted an international workshop October 23-25, 2007, in Nice, France, to review and discuss existing and emerging methods and techniques for improving the current weight-of-evidence approach for evaluating the potential allergenicity of novel proteins. The workshop included over 40 international experts from government, industry, and academia. Their expertise represented a range of disciplines including immunology, chemistry, molecular biology, bioinformatics, and toxicology. Among participants, there was consensus that (1) current bioinformatic approaches are highly conservative; (2) advances in bioinformatics using structural comparisons of proteins may be helpful as the availability of structural data increases; (3) proteomics may prove useful for monitoring the natural variability in a plant's proteome and assessing the impact of biotechnology transformations on endogenous levels of allergens, but only when analytical techniques have been standardized and additional data are available on the natural variation of protein expression in non-transgenic bred plants; (4) basophil response assays are promising techniques, but need additional evaluation around specificity, sensitivity, and reproducibility; (5) additional research is required to develop and validate an animal model for the purpose of predicting protein allergenicity.

Industrial Hardening: 1981 Technical Status-Report.

DTIC Science & Technology

1982-09-01

preparedness for nuclear disaster ), establish additional industry contacts (through which to test and evaluate the new inputs and refinements), and...handling and control of toxic (and hazardous) materials in a nuclear disaster situation are desirable. In line with our strategy to seek overlapping...earthquake preparedness that apply to a nuclear disaster requires an analysis that is less direct than comparing ground shock. Earthquake-generated

Many Proprietary Schools Do Not Comply with Department of Education's Pell Grant Program Requirements.

ERIC Educational Resources Information Center

Comptroller General of the U.S., Washington, DC.

The administration of the Pell Grant program by proprietary schools was assessed with a randomly selected sample of 35 schools from a universe of 1,165 schools. In addition to evaluating records of 761 students, officials who administered the program were interviewed. The following practices by schools did not comply with the Pell program…

A Decision Tool to Evaluate Budgeting Methodologies for Estimating Facility Recapitalization Requirements

DTIC Science & Technology

2008-03-01

1 . Maintenance Practices Influence Service Life .......................................................... 11 2 . Expectations or Standards May...BRB, 1991, p. 1 - 2 ) Additionally, public sector organizations typically have a larger inventory of facilities to maintain, making asset management...questions were answered. 1 . What are the long term causes and effects of under-funding the maintenance of facilities? 2 . What methods currently

Damage tolerance certification of a fighter horizontal stabilizer

NASA Astrophysics Data System (ADS)

Huang, Jia-Yen; Tsai, Ming-Yang; Chen, Jong-Sheng; Ong, Ching-Long

1995-05-01

A review of the program for the damage tolerance certification test of a composite horizontal stabilizer (HS) of a fighter is presented. The object of this program is to certify that the fatigue life and damage tolerance strength of a damaged composite horizontal stabilizer meets the design requirements. According to the specification for damage tolerance certification, a test article should be subjected to two design lifetimes of flight-by-flight load spectra simulating the in-service fatigue loading condition for the aircraft. However, considering the effect of environmental change on the composite structure, one additional lifetime test was performed. In addition, to evaluate the possibilities for extending the service life of the structure, one more lifetime test was carried out with the spectrum increased by a factor of 1.4. To assess the feasibility and reliability of repair technology on a composite structure, two damaged areas were repaired after two lifetimes of damage tolerance test. On completion of four lifetimes of the damage tolerance test, the static residual strength was measured to check whether structural strength after repair met the requirements. Stiffness and static strength of the composite HS with and without damage were evaluated and compared.

Approaches for the Application of Physiologically Based ...

EPA Pesticide Factsheets

This draft report of Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment addresses the application and evaluation of PBPK models for risk assessment purposes. These models represent an important class of dosimetry models that are useful for predicting internal dose at target organs for risk assessment applications. Topics covered include:the types of data required use of PBPK models in risk assessment,evaluation of PBPK models for use in risk assessment, andthe application of these models to address uncertainties resulting from extrapolations (e.g. interspecies extrapolation) often used in risk assessment.In addition, appendices are provided that includea compilation of chemical partition coefficients and rate constants,algorithms for estimating chemical-specific parameters, anda list of publications relating to PBPK modeling. This report is primarily meant to serve as a learning tool for EPA scientists and risk assessors who may be less familiar with the field. In addition, this report can be informative to PBPK modelers within and outside the Agency, as it provides an assessment of the types of data and models that the EPA requires for consideration of a model for use in risk assessment.

The analysis of a generic air-to-air missile simulation model

NASA Technical Reports Server (NTRS)

Kaplan, Joseph A.; Chappell, Alan R.; Mcmanus, John W.

1994-01-01

A generic missile model was developed to evaluate the benefits of using a dynamic missile fly-out simulation system versus a static missile launch envelope system for air-to-air combat simulation. This paper examines the performance of a launch envelope model and a missile fly-out model. The launch envelope model bases its probability of killing the target aircraft on the target aircraft's position at the launch time of the weapon. The benefits gained from a launch envelope model are the simplicity of implementation and the minimal computational overhead required. A missile fly-out model takes into account the physical characteristics of the missile as it simulates the guidance, propulsion, and movement of the missile. The missile's probability of kill is based on the missile miss distance (or the minimum distance between the missile and the target aircraft). The problems associated with this method of modeling are a larger computational overhead, the additional complexity required to determine the missile miss distance, and the additional complexity of determining the reason(s) the missile missed the target. This paper evaluates the two methods and compares the results of running each method on a comprehensive set of test conditions.

CEOS SEO and GISS Meeting

NASA Technical Reports Server (NTRS)

Killough, Brian; Stover, Shelley

2008-01-01

The Committee on Earth Observation Satellites (CEOS) provides a brief to the Goddard Institute for Space Studies (GISS) regarding the CEOS Systems Engineering Office (SEO) and current work on climate requirements and analysis. A "system framework" is provided for the Global Earth Observation System of Systems (GEOSS). SEO climate-related tasks are outlined including the assessment of essential climate variable (ECV) parameters, use of the "systems framework" to determine relevant informational products and science models and the performance of assessments and gap analyses of measurements and missions for each ECV. Climate requirements, including instruments and missions, measurements, knowledge and models, and decision makers, are also outlined. These requirements would establish traceability from instruments to products and services allowing for benefit evaluation of instruments and measurements. Additionally, traceable climate requirements would provide a better understanding of global climate models.

Separations in the STATS report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choppin, G.R.

1996-12-31

The Separations Technology and Transmutation Systems (STATS) Committee formed a Subcommittee on Separations. This subcommittee was charged with evaluating the separations proposed for the several reactor and accelerator transmutation systems. It was also asked to review the processing options for the safe management of high-level waste generated by the defense programs, in particular, the special problems involved in dealing with the waste at the U.S. Department of Energy (DOE) facility in Hanford, Washington. Based on the evaluations from the Subcommittee on Separations, the STATS Committee concluded that for the reactor transmutation programs, aqueous separations involving a combination of PUREX andmore » TRUEX solvent extraction processes could be used. However, additional research and development (R&D) would be required before full plant-scale use of the TRUEX technology could be employed. Alternate separations technology for the reactor transmutation program involves pyroprocessing. This process would require a significant amount of R&D before its full-scale application can be evaluated.« less

Report on SARS backfit evaluation, Catalytic, Inc. Solvent Refined Coal Pilot Plant, Wilsonville, Alabama

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyer, A.F. Jr.

1980-07-02

A site visit was made in company with the DOE-OPTA-EA Safety and Health Official for the purpose of providing that official with technical assistance in evaluating the validity of an earlier DOE-OPTA recommendation exempting this facility from the Safety and Analysis and Review backfit requirements of DOE Order 5481.1. A further purpose of the visit was to assess and evaluate the occupational safety and health program at this facility, as compared with the criteria and guidelines contained in ASFE Order 5481.1. Adequate documentation regarding compliance with codes, standards, and regulations were observed at this facility. There is in existence anmore » ongoing continuous safety analysis effort for both modifications or additions to this facility. Adequate environmental safeguards and plans and procedures were observed. The SARS backfit exemption is appropriate. The occupational safety and health program is in many ways a model for the scope of work and nature of hazards involved, and is consistent with ASFE guidelines and statutory requirements.« less

Safe use of vaccines and vaccine compliance with food safety requirements.

PubMed

Grein, K; Papadopoulos, O; Tollis, M

2007-08-01

Advanced technologies and regulatory regimes have contributed to the availability of veterinary vaccines that have high quality and favourable safety profiles in terms of potential risks posed to the target animals, the persons who come into contact with the vaccine, the consumers of food derived from vaccinated animals and the environment. The authorisation process requires that a range of safety studies are provided to evaluate the products. The design and production of vaccines, and their safe use, are primarily assessed by using data gathered from extensive pre-marketing studies performed on target animals and specific quality tests. The current post-marketing safeguards include good manufacturing practices, batch safety testing, inspections and pharmacovigilance. In addition to hazard identification, a full benefit/risk evaluation needs to be undertaken. The outcome of that evaluation will determine options for risk management and affect regulatory decisions on the safety of the vaccine; options might, for example, include special warnings on package inserts and labels.

Evaluation of a pet-assisted living intervention for improving functional status in assisted living residents with mild to moderate cognitive impairment: a pilot study.

PubMed

Friedmann, Erika; Galik, Elizabeth; Thomas, Sue A; Hall, P Sue; Chung, Seon Yoon; McCune, Sandra

2015-05-01

In older adults with cognitive impairment (CI), decreased functional status and increased behavioral symptoms require relocation from assisted living (AL) to nursing homes. Studies support positive effects of pets on health/function. Evaluate the effectiveness of the Pet AL (PAL) intervention to support physical, behavioral, and emotional function in AL residents with CI. Cognitively impaired AL residents randomized to 60-90 minute sessions [PAL (n = 22) or reminiscing (n = 18)] twice/week for 12 weeks. PAL interventionist encourages residents to perform skills with the visiting dog; reminiscing interventionist encourages residents to reminisce. Monthly assessment of physical (energy expenditure, activities of daily living), emotional (depression, apathy), and behavioral (agitation) function. In linear mixed models, physical activity depressive symptoms improved more with PAL. Evidence supports that the PAL program helps preserve/enhance function of AL residents with CI. Additional study is required to evaluate the duration and predictors of effectiveness of the PAL intervention. © The Author(s) 2014.

How discriminating are discriminative instruments?

PubMed

Hankins, Matthew

2008-05-27

The McMaster framework introduced by Kirshner & Guyatt is the dominant paradigm for the development of measures of health status and health-related quality of life (HRQL). The framework defines the functions of such instruments as evaluative, predictive or discriminative. Evaluative instruments are required to be sensitive to change (responsiveness), but there is no corresponding index of the degree to which discriminative instruments are sensitive to cross-sectional differences. This paper argues that indices of validity and reliability are not sufficient to demonstrate that a discriminative instrument performs its function of discriminating between individuals, and that the McMaster framework would be augmented by the addition of a separate index of discrimination. The coefficient proposed by Ferguson (Delta) is easily adapted to HRQL instruments and is a direct, non-parametric index of the degree to which an instrument distinguishes between individuals. While Delta should prove useful in the development and evaluation of discriminative instruments, further research is required to elucidate the relationship between the measurement properties of discrimination, reliability and responsiveness.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scharf, S.C.; Blaufox, M.D.

Radionuclide renography and renal scanning techniques are ideally suited to the initial and follow-up evaluation of patients with obstructive uropathy. While other modalities are superior in their ability to provide anatomic information, the radionuclide study yields functional information for each kidney without the necessity to resort to invasive studies. In addition, the Nuclear Medicine study is well suited to the evaluation of obstruction where serial studies often are required because of a lower radiation burden compared to urography. This lower radiation dose is especially important in obstruction because of the recurrent nature of several kinds of obstructive uropathy and becausemore » of the high incidence in the pediatric age group. The ability to control urine flow rate during the procedure through dehydration or administration of diuretics is an additional benefit. Increasing availability of computerization of nuclear medicine procedures as well as interest in studies employing physiologic intervention (including the diuresis renogram) have assured an important place for radionuclide studies in the evaluation of patients with urinary obstruction.« less

Evaluation of the impact of noise metrics on tiltrotor aircraft design

NASA Technical Reports Server (NTRS)

Sternfeld, H.; Spencer, R.; Ziegenbein, P.

1995-01-01

A subjective noise evaluation was conducted in which the test participants evaluated the annoyance of simulated sounds representative of future civil tiltrotor aircraft. The subjective responses were correlated with the noise metrics of A-weighted sound pressure level, overall sound pressure level, and perceived level. The results indicated that correlation between subjective response and A-weighted sound pressure level is considerably enhanced by combining it in a multiple regression with overall sound pressure level. As a single metric, perceived level correlated better than A-weighted sound pressure level due to greater emphasis on low frequency noise components. This latter finding was especially true for indoor noise where the mid and high frequency noise components are attenuated by typical building structure. Using the results of the subjective noise evaluation, the impact on tiltrotor aircraft design was also evaluated. While A-weighted sound pressure level can be reduced by reduction in tip speed, an increase in number of rotor blades is required to achieve significant reduction of low frequency noise as measured by overall sound pressure level. Additional research, however, is required to achieve comparable reductions in impulsive noise due to blade-vortex interaction, and also to achieve reduction in broad band noise.

Influence of stressful life events on the onset of sarcoidosis.

PubMed

Yamada, Yoshihito; Tatsumi, Koichiro; Yamaguchi, Tetsuo; Tanabe, Nobuhiro; Takiguchi, Yuichi; Kuriyama, Takayuki; Mikami, Riichiro

2003-06-01

The onset of sarcoidosis may be triggered by any hereditary and/or environmental factor. Among these factors, psychosocial stress may play a critical role in the onset of sarcoidosis. The aim of the present study was to evaluate the influence of stressful life events on the onset of sarcoidosis. The social and/or life events experienced prior to diagnosis in 55 patients with sarcoidosis, were evaluated quantitatively using the Social Readjustment Rating Scale (SRRS), the most authoritative method to quantify the magnitude of the events requiring changes in lifestyle. In addition, personality with respect to stress-reactivity was simultaneously evaluated using the Minnesota Multiphasic Personality Inventory (MMPI) alexithymia scale. Both the degree of stress, evaluated by SRRS, and stress-reactivity, evaluated by MMPI scale, of sarcoidosis patients were compared with those of 92 healthy controls. The magnitude of stressful life events was significantly higher in patients with sarcoidosis compared with healthy controls. In addition, capacity for coping with stress was found to be inferior in sarcoidosis patients compared with that in the control groups. These results indicated that psychosocial stress assessed on the basis of alexithymic characteristics of the self perception of stress may be partly implicated in the development of sarcoidosis.

46 CFR 15.525 - Additional manning requirements for tank vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Additional manning requirements for tank vessels. 15.525... MANNING REQUIREMENTS Manning Requirements; Inspected Vessels § 15.525 Additional manning requirements for tank vessels. Parts 31 and 35 of this chapter contain additional manning requirements applicable to...

A Parametric Study of Actuator Requirements for Active Turbine Tip Clearance Control of a Modern High Bypass Turbofan Engine

NASA Technical Reports Server (NTRS)

Kratz, Jonathan L.; Chapman, Jeffryes W.; Guo, Ten-Huei

2017-01-01

The efficiency of aircraft gas turbine engines is sensitive to the distance between the tips of its turbine blades and its shroud, which serves as its containment structure. Maintaining tighter clearance between these components has been shown to increase turbine efficiency, increase fuel efficiency, and reduce the turbine inlet temperature, and this correlates to a longer time-on-wing for the engine. Therefore, there is a desire to maintain a tight clearance in the turbine, which requires fast response active clearance control. Fast response active tip clearance control will require an actuator to modify the physical or effective tip clearance in the turbine. This paper evaluates the requirements of a generic active turbine tip clearance actuator for a modern commercial aircraft engine using the Commercial Modular Aero-Propulsion System Simulation 40k (C-MAPSS40k) software that has previously been integrated with a dynamic tip clearance model. A parametric study was performed in an attempt to evaluate requirements for control actuators in terms of bandwidth, rate limits, saturation limits, and deadband. Constraints on the weight of the actuation system and some considerations as to the force which the actuator must be capable of exerting and maintaining are also investigated. From the results, the relevant range of the evaluated actuator parameters can be extracted. Some additional discussion is provided on the challenges posed by the tip clearance control problem and the implications for future small core aircraft engines.

Java Mission Evaluation Workstation System

NASA Technical Reports Server (NTRS)

Pettinger, Ross; Watlington, Tim; Ryley, Richard; Harbour, Jeff

2006-01-01

The Java Mission Evaluation Workstation System (JMEWS) is a collection of applications designed to retrieve, display, and analyze both real-time and recorded telemetry data. This software is currently being used by both the Space Shuttle Program (SSP) and the International Space Station (ISS) program. JMEWS was written in the Java programming language to satisfy the requirement of platform independence. An object-oriented design was used to satisfy additional requirements and to make the software easily extendable. By virtue of its platform independence, JMEWS can be used on the UNIX workstations in the Mission Control Center (MCC) and on office computers. JMEWS includes an interactive editor that allows users to easily develop displays that meet their specific needs. The displays can be developed and modified while viewing data. By simply selecting a data source, the user can view real-time, recorded, or test data.

Capabilities and applications of the Program to Optimize Simulated Trajectories (POST). Program summary document

NASA Technical Reports Server (NTRS)

Brauer, G. L.; Cornick, D. E.; Stevenson, R.

1977-01-01

The capabilities and applications of the three-degree-of-freedom (3DOF) version and the six-degree-of-freedom (6DOF) version of the Program to Optimize Simulated Trajectories (POST) are summarized. The document supplements the detailed program manuals by providing additional information that motivates and clarifies basic capabilities, input procedures, applications and computer requirements of these programs. The information will enable prospective users to evaluate the programs, and to determine if they are applicable to their problems. Enough information is given to enable managerial personnel to evaluate the capabilities of the programs and describes the POST structure, formulation, input and output procedures, sample cases, and computer requirements. The report also provides answers to basic questions concerning planet and vehicle modeling, simulation accuracy, optimization capabilities, and general input rules. Several sample cases are presented.

Watermarking textures in video games

NASA Astrophysics Data System (ADS)

Liu, Huajian; Berchtold, Waldemar; Schäfer, Marcel; Lieb, Patrick; Steinebach, Martin

2014-02-01

Digital watermarking is a promising solution to video game piracy. In this paper, based on the analysis of special challenges and requirements in terms of watermarking textures in video games, a novel watermarking scheme for DDS textures in video games is proposed. To meet the performance requirements in video game applications, the proposed algorithm embeds the watermark message directly in the compressed stream in DDS files and can be straightforwardly applied in watermark container technique for real-time embedding. Furthermore, the embedding approach achieves high watermark payload to handle collusion secure fingerprinting codes with extreme length. Hence, the scheme is resistant to collusion attacks, which is indispensable in video game applications. The proposed scheme is evaluated in aspects of transparency, robustness, security and performance. Especially, in addition to classical objective evaluation, the visual quality and playing experience of watermarked games is assessed subjectively in game playing.

Development and evaluation of an algorithm to facilitate drug prescription for inpatients with feeding tubes.

PubMed

Lohmann, Kristina; Freigofas, Julia; Leichsenring, Julian; Wallenwein, Chantal Marie; Haefeli, Walter Emil; Seidling, Hanna Marita

2015-04-01

We aimed to develop and evaluate an algorithm to facilitate drug switching between primary and tertiary care for patients with feeding tubes. An expert consortium developed an algorithm and applied it manually to 267 preadmission drugs of 46 patients admitted to a surgical ward of a tertiary care university hospital between June 12 and December 2, 2013, and requiring a feeding tube during their inpatient stay. The new algorithm considered the following principles: Drugs should be ideally listed on the hospital drug formulary (HDF). Additionally, drugs should include the same ingredient instead of a therapeutic equivalent. Preferred dosage forms were appropriate liquids, followed by solid drugs with liquid administration form, and solid drugs that could be crushed and/or suspended. Of all evaluated drugs, 83.5% could be switched to suitable drugs listed on the HDF and another 6.0% to drugs available on the German drug market. Additionally, for 4.1% of the drugs, the integration of individual switching rules allowed the switch from enteric-coated to immediate-release drugs. Consequently, 6.4% of the drugs could not be automatically switched and required case-to-case decision by a clinical professional (e.g., from sustained-release to immediate-release). The predefined principles were successfully integrated in the new algorithm. Thus, the algorithm switched more than 90% of the evaluated preadmission drugs to suitable drugs for inpatients with feeding tubes. This finding suggests that the algorithm can readily be transferred to an electronic format and integrated into a clinical decision support system.

Study to evaluate the integration of a mass spectrometer with a wet chemistry instrument. [for amino acid analysis

NASA Technical Reports Server (NTRS)

1974-01-01

The charactertistics and performance capability of the current Viking '75 Gas Chromatograph/Mass Spectrometer Instrument are reviewed and documented for the purpose of possible integration with a wet chemistry instrument. Interface, high mass discrimination, and vacuum requirements were determined in a simulated flight investigation. Suggestions for future investigations, tradeoff studies, and design modifications are presented, along with the results of column bleed measurements. A preliminary design of an integrated Wet Chemistry/Mass Spectrometer instrument for amino acid analysis is shown, including estimates of additional weight, volume, and power requirements.

Universal computer test stand (recommended computer test requirements). [for space shuttle computer evaluation

NASA Technical Reports Server (NTRS)

1973-01-01

Techniques are considered which would be used to characterize areospace computers with the space shuttle application as end usage. The system level digital problems which have been encountered and documented are surveyed. From the large cross section of tests, an optimum set is recommended that has a high probability of discovering documented system level digital problems within laboratory environments. Defined is a baseline hardware, software system which is required as a laboratory tool to test aerospace computers. Hardware and software baselines and additions necessary to interface the UTE to aerospace computers for test purposes are outlined.

Workplace Wellness Programs: How Regulatory Flexibility Might Undermine Success

PubMed Central

2014-01-01

The Patient Protection and Affordable Care Act revised the law related to workplace wellness programs, which have become part of the nation’s broader health strategy. Health-contingent programs are required to be reasonably designed. However, the regulatory requirements are lax and might undermine program efficacy in terms of both health gains and financial return. I propose a method for the government to support a best-practices approach by considering an accreditation or certification process. Additionally I discuss the need for program evaluation and the potential for employers to be subject to litigation if programs are not carefully implemented. PMID:25211713

National Aeronautics and Space Administration Manned Spacecraft Center data base requirements study

NASA Technical Reports Server (NTRS)

1971-01-01

A study was conducted to evaluate the types of data that the Manned Spacecraft Center (MSC) should automate in order to make available essential management and technical information to support MSC's various functions and missions. In addition, the software and hardware capabilities to best handle the storage and retrieval of this data were analyzed. Based on the results of this study, recommendations are presented for a unified data base that provides a cost effective solution to MSC's data automation requirements. The recommendations are projected through a time frame that includes the earth orbit space station.

Can clinical CT data improve forensic reconstruction?

PubMed

Schuh, P; Scheurer, E; Fritz, K; Pavlic, M; Hassler, E; Rienmüller, R; Yen, K

2013-05-01

In accidents resulting in severe injuries, a clinical forensic examination is generally abandoned in the initial phase due to high-priority clinical needs. However, in many cases, data from clinical computed tomography (CT) examinations are available. The goals of this prospective study were (a) to evaluate clinical CT data as a basis for forensic reconstruction of the sequence of events, (b) to assess if forensic radiological follow-up reading improves the forensic diagnostic benefit compared to the written clinical radiological reports, and (c) to evaluate if full data storage including additional reconstructed 0.6-mm slices enhances forensic analysis. Clinical CT data of 15 living individuals with imaging of at least the head, thorax, and abdomen following polytrauma were examined regarding the forensic evaluation of the sequence of events. Additionally, 0.6-mm slices and 3D images were reconstructed for forensic purposes and used for the evaluation. At the forensic radiological readings, additional traumatic findings were observed in ten of the 15 patients. The main weakness of the clinical reports was that they were not detailed enough, particularly regarding the localization of injuries and description of wound morphology. In seven cases, however, forensic conclusions were possible on the basis of the written clinical reports, whereas in five cases forensic reconstruction required specific follow-up reading. The additional 0.6-mm slices were easily available and with improved 3D image quality and forensic diagnostics. In conclusion, the use of clinical CT data can considerably support forensic expertise regarding reconstruction issues. Forensic follow-up reading as well as the use of additional thin slices for 3D analysis can further improve its benefit for forensic reconstruction purposes.

HF propagation factors affecting the design and operation of real time, channel evaluation, adaptive systems

NASA Astrophysics Data System (ADS)

Aarons, J.; Grossi, M. D.

1982-08-01

To develop and operate an adaptive system, propagation factors of the ionospheric medium must be given to the designer. The operation of the system must change as a function of multipath spread, Doppler spread, path losses, channel correlation functions, etc. In addition, NATO mid-latitude HF transmission and transauroral paths require varying system operation, which must fully utilize automatic path diversity across transauroral paths. Current research and literature are reviewed to estimate the extent of the available technical information. Additional investigations to allow designers to orient new systems on realistic models of these parameters are suggested.

Microelectronics Instrument Products Shock and Vibration Electro-Optics. Section B; Acceptance Data Package

NASA Technical Reports Server (NTRS)

1995-01-01

The motor/encoder (henceforth referred to as the UUT) test sequence began with a baseline functional evaluation, which demonstrated that the motor satisfied the operating torque, cogging torque, winding resistance, and mechanical requirements of SOW. In addition, the encoder electrical requirements were verified, as well as the alignment of the encoder outputs relative to the motor shaft position. There were no discrepancies observed in this portion of the test. The UUT was then exposed to a number of environments, including thermal vacuum, thermal cycling, random and sine vibration, and mechanical shock. During the thermal environments, the performance of the UUT under load was verified at specified points in the cycles, as described in ATP 20049. In addition, the UUT was bench tested between the two thermal environments. No anomalies were observed during the thermal tests. The vibration and shock tests were performed by East-West Technology Corporation, West Babylon, New York. The UUT was delivered to the lab in a sealed vibration fixture in order to maintain the cleanliness levels required by the SOW. In addition, a three ounce load was attached to the motor shaft. The attachment method of this load caused damage to the shaft and bearing during random vibration of S/N 0003 on April 28, 1995, and is described further in NCR 00168.

Procurement engineering - the productivity factor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bargerstock, S.B.

1993-01-01

The industry is several years on the road to implementation of the Nuclear Management and Resources Council (NUMARC) initiatives on commercial-grade item dedication and procurement. Utilities have taken several approaches to involve engineering in the procurement process. A common result for the approaches is the additional operations and maintenance (O M) cost imposed by the added resource requirements. Procurement engineering productivity is a key element in controlling this business area. Experience shows that 400 to 500% improvements in productivity are possible with a 2-yr period. Improving the productivity of the procurement engineering function is important in today's competitive utility environment.more » Procurement engineering typically involves four distinct technical evaluation responsibilities along with several administrative areas. Technical evaluations include the functionally based safety classification of replacement components and parts (lacking a master parts list), the determination of dedication requirements for safety-related commercial-grade items, the preparation of a procurement specification to maintain the licensed design bases, and the equivalency evaluation of alternate items not requiring the design-change process. Administrative duties include obtaining technical review of vendor-supplied documentation, identifying obsolete parts and components, resolving material nonconformances, initiating the design-change process for replacement items (as needed), and providing technical support to O M. Although most utilities may not perform or require all the noted activities, a large percentage will apply to each utility station.« less

Separation of high-resolution samples of overlapping latent fingerprints using relaxation labeling

NASA Astrophysics Data System (ADS)

Qian, Kun; Schott, Maik; Schöne, Werner; Hildebrandt, Mario

2012-06-01

The analysis of latent fingerprint patterns generally requires clearly recognizable friction ridge patterns. Currently, overlapping latent fingerprints pose a major problem for traditional crime scene investigation. This is due to the fact that these fingerprints usually have very similar optical properties. Consequently, the distinction of two or more overlapping fingerprints from each other is not trivially possible. While it is possible to employ chemical imaging to separate overlapping fingerprints, the corresponding methods require sophisticated fingerprint acquisition methods and are not compatible with conventional forensic fingerprint data. A separation technique that is purely based on the local orientation of the ridge patterns of overlapping fingerprints is proposed by Chen et al. and quantitatively evaluated using off-the-shelf fingerprint matching software with mostly artificially composed overlapping fingerprint samples, which is motivated by the scarce availability of authentic test samples. The work described in this paper adapts the approach presented by Chen et al. for its application on authentic high resolution fingerprint samples acquired by a contactless measurement device based on a Chromatic White Light (CWL) sensor. An evaluation of the work is also given, with the analysis of all adapted parameters. Additionally, the separability requirement proposed by Chen et al. is also evaluated for practical feasibility. Our results show promising tendencies for the application of this approach on high-resolution data, yet the separability requirement still poses a further challenge.

Disparities in completion rates of the medical prerenal transplant evaluation by race or ethnicity and gender.

PubMed

Monson, Rebecca S; Kemerley, Patricia; Walczak, Douglas; Benedetti, Enrico; Oberholzer, Jose; Danielson, Kirstie K

2015-01-01

A significant number of potential kidney transplant candidates do not complete the required medical evaluation after referral to a transplant program. Factors associated with rate of completion of the renal transplant evaluation were analyzed using a retrospective chart review of patients first seen between October 1, 2009, and September 30, 2010 (n=256). The primary endpoint was completion in 12 months. Independent variables included socioeconomic, demographic, and medical factors. Mean age was 50.7 years; 49.6% were black, 28.5% Hispanic, and 21.9% white and other; 26.3% did not require dialysis. During follow-up, 23.4% did not complete the evaluation. Multivariable analysis indicated that slower rates of completion were associated with needing a greater number of medical tests (compared to 0-2: 3-5 tests, hazard ratio [HR]=0.65, P=0.02; ≥ 6 tests, HR=0.47, P=0.0005) and requiring more than one hospitalization (compared to none: HR=0.37, P=0.0008). A significant interaction between race or ethnicity and gender on completion was found: compared to black men, Hispanic men (HR=2.75, P<0.0001), Hispanic women (HR=1.96, P=0.006), and white men (HR=1.99, P=0.005) showed a more rapid completion. In comparison, black and white women (HR=1.38, P=0.16; HR=0.94, P=0.83, respectively) were not significantly different from black men in rates of completion. Differences by race or ethnicity and gender were not confounded by socioeconomic variables or social support. To lessen barriers and facilitate renal transplantation, black men and women, white women, and patients needing multiple medical tests and requiring several hospitalizations may benefit from additional assistance during the medical evaluation process.

A quantitative evaluation of a qualitative risk assessment framework: Examining the assumptions and predictions of the Productivity Susceptibility Analysis (PSA)

PubMed Central

2018-01-01

Qualitative risk assessment frameworks, such as the Productivity Susceptibility Analysis (PSA), have been developed to rapidly evaluate the risks of fishing to marine populations and prioritize management and research among species. Despite being applied to over 1,000 fish populations, and an ongoing debate about the most appropriate method to convert biological and fishery characteristics into an overall measure of risk, the assumptions and predictive capacity of these approaches have not been evaluated. Several interpretations of the PSA were mapped to a conventional age-structured fisheries dynamics model to evaluate the performance of the approach under a range of assumptions regarding exploitation rates and measures of biological risk. The results demonstrate that the underlying assumptions of these qualitative risk-based approaches are inappropriate, and the expected performance is poor for a wide range of conditions. The information required to score a fishery using a PSA-type approach is comparable to that required to populate an operating model and evaluating the population dynamics within a simulation framework. In addition to providing a more credible characterization of complex system dynamics, the operating model approach is transparent, reproducible and can evaluate alternative management strategies over a range of plausible hypotheses for the system. PMID:29856869

SIRU utilization. Volume 2: Software description and program documentation

NASA Technical Reports Server (NTRS)

Oehrle, J.; Whittredge, R.

1973-01-01

A complete description of the additional analysis, development and evaluation provided for the SIRU system as identified in the requirements for the SIRU utilization program is presented. The SIRU configuration is a modular inertial subsystem with hardware and software features that achieve fault tolerant operational capabilities. The SIRU redundant hardware design is formulated about a six gyro and six accelerometer instrument module package. The modules are mounted in this package so that their measurement input axes form a unique symmetrical pattern that corresponds to the array of perpendiculars to the faces of a regular dodecahedron. This six axes array provides redundant independent sensing and the symmetry enables the formulation of an optimal software redundant data processing structure with self-contained fault detection and isolation (FDI) capabilities. Documentation of the additional software and software modifications required to implement the utilization capabilities includes assembly listings and flow charts

Ramping and Uncertainty Prediction Tool - Analysis and Visualization of Wind Generation Impact on Electrical Grid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Etingov, Pavel; Makarov, PNNL Yuri; Subbarao, PNNL Kris

RUT software is designed for use by the Balancing Authorities to predict and display additional requirements caused by the variability and uncertainty in load and generation. The prediction is made for the next operating hours as well as for the next day. The tool predicts possible deficiencies in generation capability and ramping capability. This deficiency of balancing resources can cause serious risks to power system stability and also impact real-time market energy prices. The tool dynamically and adaptively correlates changing system conditions with the additional balancing needs triggered by the interplay between forecasted and actual load and output of variablemore » resources. The assessment is performed using a specially developed probabilistic algorithm incorporating multiple sources of uncertainty including wind, solar and load forecast errors. The tool evaluates required generation for a worst case scenario, with a user-specified confidence level.« less

[Thrombosis and post-thrombotic syndrome as a consequence of an accident].

PubMed

Wahl, U; Hirsch, T

2015-10-01

Phlebothromboses represent alarming complications in accident victims since they can cause fatal pulmonary embolisms. More than half of those affected also develop post-thrombotic syndrome in the course of the illness. In addition to making clinical assessments, the traumatologist should also have fundamental knowledge about diagnostic methods and be familiar with interpreting internal findings. Colour-coded duplex sonography plays a central role in diagnosing thrombosis and in assessing functional limitations. Further information can be gathered from various phlebological procedures. The expert evaluation of the immediate, as well as the long-term consequences of an accident frequently require leg swelling to be classified. It is not uncommon for post-thrombotic syndrome to be diagnosed for the first time during this process. An additional vascular appraisal is often required. An appreciation of social-medical and insurance-related aspects means a high degree of responsibility is placed on the expert.

High performance flight computer developed for deep space applications

NASA Technical Reports Server (NTRS)

Bunker, Robert L.

1993-01-01

The development of an advanced space flight computer for real time embedded deep space applications which embodies the lessons learned on Galileo and modern computer technology is described. The requirements are listed and the design implementation that meets those requirements is described. The development of SPACE-16 (Spaceborne Advanced Computing Engine) (where 16 designates the databus width) was initiated to support the MM2 (Marine Mark 2) project. The computer is based on a radiation hardened emulation of a modern 32 bit microprocessor and its family of support devices including a high performance floating point accelerator. Additional custom devices which include a coprocessor to improve input/output capabilities, a memory interface chip, and an additional support chip that provide management of all fault tolerant features, are described. Detailed supporting analyses and rationale which justifies specific design and architectural decisions are provided. The six chip types were designed and fabricated. Testing and evaluation of a brass/board was initiated.

Challenges of Achieving 2012 IECC Air Sealing Requirements in Multifamily Dwellings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klocke, S.; Faakye, O.; Puttagunta, S.

2014-10-01

While previous versions of the International Energy Conservation Code (IECC) have included provisions to improve the air tightness of dwellings, for the first time, the 2012 IECC mandates compliance verification through blower door testing. Simply completing the Air Barrier and Insulation Installation checklist through visual inspection is no longer sufficient by itself. In addition, the 2012 IECC mandates a significantly stricter air sealing requirement. In Climate Zones 3 through 8, air leakage may not exceed 3 ACH50, which is a significant reduction from the 2009 IECC requirement of 7 ACH50. This requirement is for all residential buildings, which includes low-risemore » multifamily dwellings. While this air leakage rate requirement is an important component to achieving an efficient building thermal envelope, currently, the code language doesn't explicitly address differences between single family and multifamily applications. In addition, the 2012 IECC does not provide an option to sample dwellings for larger multifamily buildings, so compliance would have to be verified on every unit. With compliance with the 2012 IECC air leakage requirements on the horizon, several of Consortium for Advanced Residential Building's (CARB’s) multifamily builder partners are evaluating how best to comply with this requirement. Builders are not sure whether it is more practical or beneficial to simply pay for guarded testing or to revise their air sealing strategies to improve compartmentalization to comply with code requirements based on unguarded blower door testing. This report summarizes CARB's research that was conducted to assess the feasibility of meeting the 2012 IECC air leakage requirements in 3 multifamily buildings.« less

Building America Case Study: Challenges of Achieving 2012 IECC Air Sealing Requirements in Multifamily Dwellings, Upstate New York (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2014-11-01

While previous versions of the International Energy Conservation Code (IECC) have included provisions to improve the air tightness of dwellings, for the first time, the 2012 IECC mandates compliance verification through blower door testing. Simply completing the Air Barrier and Insulation Installation checklist through visual inspection is no longer sufficient by itself. In addition, the 2012 IECC mandates a significantly stricter air sealing requirement. In Climate Zones 3 through 8, air leakage may not exceed 3 ACH50, which is a significant reduction from the 2009 IECC requirement of 7 ACH50. This requirement is for all residential buildings, which includes low-risemore » multifamily dwellings. While this air leakage rate requirement is an important component to achieving an efficient building thermal envelope, currently, the code language doesn't explicitly address differences between single family and multifamily applications. In addition, the 2012 IECC does not provide an option to sample dwellings for larger multifamily buildings, so compliance would have to be verified on every unit. With compliance with the 2012 IECC air leakage requirements on the horizon, several of CARB's multifamily builder partners are evaluating how best to comply with this requirement. Builders are not sure whether it is more practical or beneficial to simply pay for guarded testing or to revise their air sealing strategies to improve compartmentalization to comply with code requirements based on unguarded blower door testing. This report summarizes CARB's research that was conducted to assess the feasibility of meeting the 2012 IECC air leakage requirements in 3 multifamily buildings.« less

Challenges of Achieving 2012 IECC Air Sealing Requirements in Multifamily Dwellings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klocke, S.; Faakye, O.; Puttagunta, S.

2014-10-01

​While previous versions of the International Energy Conservation Code (IECC) have included provisions to improve the air tightness of dwellings, for the first time, the 2012 IECC mandates compliance verification through blower door testing. Simply completing the Air Barrier and Insulation Installation checklist through visual inspection is no longer sufficient by itself. In addition, the 2012 IECC mandates a significantly stricter air sealing requirement. In Climate Zones 3 through 8, air leakage may not exceed 3 ACH50, which is a significant reduction from the 2009 IECC requirement of 7 ACH50. This requirement is for all residential buildings, which includes low-risemore » multifamily dwellings. While this air leakage rate requirement is an important component to achieving an efficient building thermal envelope, currently, the code language doesn't explicitly address differences between single family and multifamily applications. In addition, the 2012 IECC does not provide an option to sample dwellings for larger multifamily buildings, so compliance would have to be verified on every unit. With compliance with the 2012 IECC air leakage requirements on the horizon, several of CARB's multifamily builder partners are evaluating how best to comply with this requirement. Builders are not sure whether it is more practical or beneficial to simply pay for guarded testing or to revise their air sealing strategies to improve compartmentalization to comply with code requirements based on unguarded blower door testing. This report summarizes CARB's research that was conducted to assess the feasibility of meeting the 2012 IECC air leakage requirements in 3 multifamily buildings.« less

Evaluation and treatment of urinary incontinence in long term care.

PubMed

Pannill, F C; Williams, T F; Davis, R

1988-10-01

All elderly patients with established urinary incontinence residing in an intermediate care facility during one year were evaluated for medical and urological conditions contributing to the incontinence; treatment was initiated for all diagnosed problems if possible. Unstable detrusor function (65%), sphincter weakness (13%), and overflow incontinence (10%) were all frequent urological causes, although several patients required extensive testing in addition to cystometrics to establish a complete diagnosis. Frequent nonurological causes of incontinence included behavioral problems (53%), immobility (45%), medication problems (24%), diabetes (18%), and local pathology (47%). Thirty-seven percent had three or more conditions identified. Treatment aimed at nonurological causes was more successful in ameliorating incontinence than urological medication; side effects were significant limitations to urological treatment success. Of the 22 patients who completed evaluation, treatment, and follow-up, five patients (23%) were cured, three (14%) showed at least a 65% decrease in incontinence, four (18%) showed at least a 30% decrease in incontinence, and 10 (45%) showed no change or worsened. We conclude that nonurological problems frequently contribute to urinary incontinence in long term care facilities; incontinence in some of these patients can be improved without urological therapy. Nonurological problems need careful definition and treatment; patients whose incontinence persists require comprehensive urological evaluation and therapy. A complete solution to incontinence in this setting may require safer drugs and better understanding of urinary pathophysiology.

IMPGSS - International Medical Program Global Satellite System

DTIC Science & Technology

2004-02-01

additional comments regarding the significance of working with Tachyon and NASK under this Contract). 5.2.5 Requirements - Country/Region Assessments...services on a tentative exploratory basis by Tachyon ]. 5.2.7 Program Development Deliverable A 007 This is currently summarized in the Program Content...based satellite transmissions and transmission pricing based on segmented, limited use data volumes via Tachyon . " A more involved use of evaluation

Community Environmental Response Facilitation Act (CERFA) Report, Nike Battery Kansas City 30, Pleasant Hill, Missouri

DTIC Science & Technology

1994-04-01

environment . * A number of environmentally significant operation identified through Enhanced PA investigations have the potential to affect human health...and environment and represent areas requiring environmental evaluation. Additional investigation, such as sampling of a variety of media including...Best Available. Copy AD-A281 929 IIIIIIIIII•. Community Environmental Response Facilitation Act (CERFA) Report Nike Battery Kansas City 30 Pleasant

Additive Manufacturing for Superalloys - Producibility and Cost Validation (Preprint)

DTIC Science & Technology

2011-03-01

evaluated in this study were: Shaped Metal Deposition (SMD, 3D Weld Deposition) Laser Powder Deposition (LPD) Electron Beam Wire Deposition (EBWD...envelope and would be removed during subsequent machining. Radiographic inspection also revealed fine random internal micro porosity in some of the...successfully fabricated the required deposition samples for Task 2 (see Figure 4). A surface examination revealed some surface cracks and porosity , but all

Robust stability of linear systems: Some computational considerations

NASA Technical Reports Server (NTRS)

Laub, A. J.

1979-01-01

The cases of both additive and multiplicative perturbations were discussed and a number of relationships between the two cases were given. A number of computational aspects of the theory were also discussed, including a proposed new method for evaluating general transfer or frequency response matrices. The new method is numerically stable and efficient, requiring only operations to update for new values of the frequency parameter.

Science on Drupal: An evaluation of CMS Technologies

NASA Astrophysics Data System (ADS)

Vinay, S.; Gonzalez, A.; Pinto, A.; Pascuzzi, F.; Gerard, A.

2011-12-01

We conducted an extensive evaluation of various Content Management System (CMS) technologies for implementing different websites supporting interdisciplinary science data and information. We chose two products, Drupal and Bluenog/Hippo CMS, to meet our specific needs and requirements. Drupal is an open source product that is quick and easy to setup and use. It is a very mature, stable, and widely used product. It has rich functionality supported by a large and active user base and developer community. There are many plugins available that provide additional features for managing citations, map gallery, semantic search, digital repositories (fedora), scientific workflows, collaborative authoring, social networking, and other functions. All of these work very well within the Drupal framework if minimal customization is needed. We have successfully implemented Drupal for multiple projects such as: 1) the Haiti Regeneration Initiative (http://haitiregeneration.org/); 2) the Consortium on Climate Risk in the Urban Northeast (http://beta.ccrun.org/); and 3) the Africa Soils Information Service (http://africasoils.net/). We are also developing two other websites, the Côte Sud Initiative (CSI) and Emerging Infectious Diseases, using Drupal. We are testing the Drupal multi-site install for managing different websites with one install to streamline the maintenance. In addition, paid support and consultancy for Drupal website development are available at affordable prices. All of these features make Drupal very attractive for implementing state-of-the-art scientific websites that do not have complex requirements. One of our major websites, the NASA Socioeconomic Data and Applications Center (SEDAC), has a very complex set of requirements. It has to easily re-purpose content across multiple web pages and sites with different presentations. It has to serve the content via REST or similar standard interfaces so that external client applications can access content in the CMS repository. This means the content repository and structure should be completely separated from the content presentation and site structure. In addition to the CMS repository, the front-end website has to be able to consume, integrate, and display diverse content flexibly from multiple back-end systems, including custom and legacy systems, such as Oracle, Geoserver, Flickr, Fedora, and other web services. We needed the ability to customize the workflow to author, edit, approve, and publish content based on different content types and project requirements. In addition, we required the ability to use the existing active directory for user management with support for roles and groups and permissions using Access Control List (ACL) model. The ability to version and lock content was also important. We determined that most of these capabilities are difficult to implement with Drupal and needed significant customization. The Bluenog eCMS (enterprise CMS) product satisfied most of these requirements. Bluenog eCMS is based on an open source product called Hippo with customizations and support provided by the vendor Bluenog. Our newly redesigned and recently released SEDAC website, http://sedac.ciesin.columbia.edu, is implemented using Bluenog eCMS. Other products we evaluated include WebLogic portal, Magnolia, Liferay portal, and Alfresco.

Metrological reliability of optical coherence tomography in biomedical applications

NASA Astrophysics Data System (ADS)

Goloni, C. M.; Temporão, G. P.; Monteiro, E. C.

2013-09-01

Optical coherence tomography (OCT) has been proving to be an efficient diagnostics technique for imaging in vivo tissues, an optical biopsy with important perspectives as a diagnostic tool for quantitative characterization of tissue structures. Despite its established clinical use, there is no international standard to address the specific requirements for basic safety and essential performance of OCT devices for biomedical imaging. The present work studies the parameters necessary for conformity assessment of optoelectronics equipment used in biomedical applications like Laser, Intense Pulsed Light (IPL), and OCT, targeting to identify the potential requirements to be considered in the case of a future development of a particular standard for OCT equipment. In addition to some of the particular requirements standards for laser and IPL, also applicable for metrological reliability analysis of OCT equipment, specific parameters for OCT's evaluation have been identified, considering its biomedical application. For each parameter identified, its information on the accompanying documents and/or its measurement has been recommended. Among the parameters for which the measurement requirement was recommended, including the uncertainty evaluation, the following are highlighted: optical radiation output, axial and transverse resolution, pulse duration and interval, and beam divergence.

Energy saving and consumption reducing evaluation of thermal power plant

NASA Astrophysics Data System (ADS)

Tan, Xiu; Han, Miaomiao

2018-03-01

At present, energy saving and consumption reduction require energy saving and consumption reduction measures for thermal power plant, establishing an evaluation system for energy conservation and consumption reduction is instructive for the whole energy saving work of thermal power plant. By analysing the existing evaluation system of energy conservation and consumption reduction, this paper points out that in addition to the technical indicators of power plant, market activities should also be introduced in the evaluation of energy saving and consumption reduction in power plant. Ttherefore, a new evaluation index of energy saving and consumption reduction is set up and the example power plant is calculated in this paper. Rresults show that after introducing the new evaluation index of energy saving and consumption reduction, the energy saving effect of the power plant can be judged more comprehensively, so as to better guide the work of energy saving and consumption reduction in power plant.

Payload/orbiter contamination control assessment support

NASA Technical Reports Server (NTRS)

Rantanen, R. O.; Ress, E. B.

1975-01-01

The development and use is described of a basic contamination mathematical model of the shuttle orbiter which incorporates specific shuttle orbiter configurations and contamination sources. These configurations and sources were evaluated with respect to known shuttle orbiter operational surface characteristics and specific lines-of-sight which encompass the majority of viewing requirements for shuttle payloads. The results of these evaluations are presented as summary tables for each major source. In addition, contamination minimization studies were conducted and recommendations are made, where applicable, to support the shuttle orbiter design and operational planning for those sources which were identified to present a significant contamination threat.

A Nutritional Evaluation of the Experimental Food Service System at Travis AFB, California

DTIC Science & Technology

1974-07-01

food service experiment at Travis AFB, California was performed. The purpose of this evaluation was to determine the levels of selected nutrient elements provided by these meals and to compare them with established nutritional standards. In addition, the data provide for a comparison of the nutritional profiles of the meals served in the dining halls with those served in two new experimental food outlets. It is concluded that the meals served during the experiment were nutritionally adequate as compared to Air Force requirements, and that the meals served in the two new

SEM evaluation of metallization on semiconductors. [Scanning Electron Microscope

NASA Technical Reports Server (NTRS)

Fresh, D. L.; Adolphsen, J. W.

1974-01-01

A test method for the evaluation of metallization on semiconductors is presented and discussed. The method has been prepared in MIL-STD format for submittal as a proposed addition to MIL-STD-883. It is applicable to discrete devices and to integrated circuits and specifically addresses batch-process oriented defects. Quantitative accept/reject criteria are given for contact windows, other oxide steps, and general interconnecting metallization. Figures are provided that illustrate typical types of defects. Apparatus specifications, sampling plans, and specimen preparation and examination requirements are described. Procedures for glassivated devices and for multi-metal interconnection systems are included.

Evaluation of control and display configurations for helicopter shipboard operations

NASA Technical Reports Server (NTRS)

Paulk, C. H., Jr.; Donley, S. T.; Hollis, M. K.

1983-01-01

A simulation evaluation of several approach and landing flight-control configurations and of two out-of-the-cockpit display devices (a head-up display and a helmet-mounted display) was performed for the task of landing a helicopter on a destroyer in adverse weather. The results indicated that the ship airwake turbulence was the most significant environmental variable affecting hover performance. In addition, to achieve adequate landing performance, attitude-command control compensation was required for the pilot regardless of the display used. For improved performance with reduced pilot effort, a velocity-command, position-hold control system was desired.

Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting

PubMed Central

Doe, John E.; Lander, Deborah R.; Doerrer, Nancy G.; Heard, Nina; Hines, Ronald N.; Lowit, Anna B.; Pastoor, Timothy; Phillips, Richard D.; Sargent, Dana; Sherman, James H.; Young Tanir, Jennifer; Embry, Michelle R.

2016-01-01

Abstract The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety. A case study of the use of a pyrethroid, “pseudomethrin,” in bed netting to control malaria is presented to demonstrate the application of the roadmap and matrix. The evaluation began with a problem formulation step. The first assessment utilized existing information pertaining to the use and the class of chemistry. At each stage of the step-wise approach, the precision of the toxicity and exposure estimates were refined as necessary by obtaining key data which enabled a decision on safety to be made efficiently and with confidence. The evaluation demonstrated the concept of using existing information within the RISK21 matrix to drive the generation of additional data using a value-of-information approach. The use of the matrix highlighted whether exposure or toxicity required further investigation and emphasized the need to address the default uncertainty factor of 100 at the highest tier of the evaluation. It also showed how new methodology such as the use of in vitro studies and assays could be used to answer the specific questions which arise through the use of the matrix. The matrix also serves as a useful means to communicate progress to stakeholders during an assessment of chemical use. PMID:26517449

Iliac Artery Stent Placement Relieves Claudication in Patients with Iliac and Superficial Femoral Artery Lesions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ichihashi, Shigeo, E-mail: shigeoichihashi@yahoo.co.jp; Higashiura, Wataru; Itoh, Hirofumi

Purpose. To evaluate the efficacy of iliac artery stent placement for relief of claudication in patients with both iliac and superficial femoral artery (SFA) lesions. Methods. Stent placement for only iliac artery occlusive disease was performed in 94 limbs (74 patients) with both iliac and SFA occlusive disease on the same limb. All procedures were performed because intermittent claudication did not improve after continuation of antiplatelet medication therapy and home-based exercise for 3 months. Rutherford classification was 2 in 20 limbs and 3 in 74 limbs. Patients with critical limb ischemia were excluded. Median duration of follow-up was 40 months.more » Primary patency rates of the iliac stent, clinical improvement rates, and risk factors for requiring additional SFA procedures were evaluated. Results. Primary patency rates of the iliac stent at 1, 3, 5, and 7 years were 97, 93, 79, and 79 %, respectively. The initial clinical improvement rate was 87 %. Continued clinical improvement rates at 1, 3, 5, and 7 years were 87, 81, 69, and 66 %, respectively. SFA Trans-Atlantic Inter-Society Consensus (TASC) II C/D lesion was a significant risk factor for requiring additional SFA procedures. Conclusion. Intermittent claudication was relieved by iliac stent placement in most patients with both iliac and SFA lesions. Thus, the indications for treatment of the SFA intended for claudicants should be evaluated after treatment of the iliac lesion.« less

Addressing tuberculosis patients' medical and socio-economic needs: a comprehensive programmatic approach.

PubMed

Contreras, Carmen C; Millones, Ana K; Santa Cruz, Janeth; Aguilar, Margot; Clendenes, Martin; Toranzo, Miguel; Llaro, Karim; Lecca, Leonid; Becerra, Mercedes C; Yuen, Courtney M

2017-04-01

For a cohort of patients with tuberculosis in Carabayllo, Peru, we describe the prevalence of medical comorbidities and socio-economic needs, the efforts required by a comprehensive support programme ('TB Cero') to address them and the success of this programme in linking patients to care. Patients diagnosed with tuberculosis in Carabayllo underwent evaluations for HIV, diabetes, mental health and unmet basic needs. For patients initiating treatment during 14 September, 2015-15 May, 2016, we abstracted data from evaluation forms and a support request system. We calculated the prevalence of medical comorbidities and the need for socio-economic support at the time of tuberculosis diagnosis, as well as the proportion of patients successfully linked to care or support. Of 192 patients, 83 (43%) had at least one medical comorbidity other than tuberculosis. These included eight (4%) patients with HIV, 12 (6%) with diabetes and 62 (32%) deemed at risk for a mental health condition. Of patients who required follow-up for a comorbidity, 100% initiated antiretroviral therapy, 71% attended endocrinology consultations and 66% attended psychology consultations. Of 126 (65%) patients who completed the socio-economic evaluation, 58 (46%) reported already receiving food baskets from the municipality, and 79 (63%) were given additional support, most commonly food vouchers and assistance in accessing health care. Carabayllo tuberculosis patients face many challenges in addition to tuberculosis. A collaborative, comprehensive treatment support programme can achieve high rates of linkage to care for these needs. © 2017 John Wiley & Sons Ltd.

10 CFR 20.2302 - Additional requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

10 CFR 20.2302 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

10 CFR 20.2302 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

What do evaluations tell us about implementing new models in rural and remote primary health care? Findings from a narrative analysis of seven service evaluations conducted by an Australian Centre of Research Excellence.

PubMed

Lyle, David; Saurman, Emily; Kirby, Sue; Jones, Debra; Humphreys, John; Wakerman, John

2017-01-01

A Centre of Research Excellence (CRE) in Rural and Remote Primary Healthcare was established in 2012 with the goal of providing evidence to inform policy development to increase equity of access to quality health care and the identification of services that should be available to the diverse communities characterising Australia. This article reports on the key findings from seven CRE service evaluations to better understand what made these primary health care (PHC) models work where they worked, and why. We conducted a narrative synthesis of 15 articles reporting on seven CRE service evaluations of different PHC models published between 2012 and 2015. Three different contexts for PHC reform were evaluated: community, regional and clinic based. Themes identified were factors that enabled changes to PHC delivery, processes that supported services to improve access to PHC and requirements for service adaptation to promote sustainability. In both Indigenous and mainstream community settings, the active engagement with local communities, and their participation in, or leadership of, shared decision-making was reported across the three themes. In addition, local governance processes, informed by service activity and impact data, enabled these service changes to be sustained over time. The considerations were different for the outreach, regional and clinic services that relied on internal processes to drive change because they did not require the cooperation of multiple organisations to succeed. The review highlighted that shared decision-making, negotiation and consultation with communities is important and should be used to promote feasible strategies that improve access to community-based PHC services. There is a growing need for service evaluations to report on the feasibility, acceptability and fit of successful service models within context, in addition to reach and effectiveness in order to provide evidence for local dissemination, adaption and implementation strategies.

Moving-base simulation evaluation of thrust margins for vertical landing for the NASA YAV-8B Harrier aircraft

NASA Technical Reports Server (NTRS)

Franklin, James A.; Stortz, Michael W.

1993-01-01

A simulation experiment was conducted on Ames Research Center's Vertical Motion Simulator to evaluate the thrust margin for vertical landing required for the YAV-8B Harrier. Two different levels of ground effect were employed, representing the aircraft with or without lift improvement devices installed. In addition, two different inlet temperature profiles were included to cover a wide range of hot gas ingestion. For each ground effect and hot gas ingestion variant, vertical landings were performed at successively heavier weights, with the pilot assessing the acceptability of the operation in each case. Results are presented as a function of hover weight ratio and a metric of the mean ground effect and ingestion that reflect the increase in thrust margin required to provide acceptable control of sink rate during the descent to touchdown with increasing suck down and hot gas ingestion.

Condition monitoring of an electro-magnetic brake using an artificial neural network

NASA Astrophysics Data System (ADS)

Gofran, T.; Neugebauer, P.; Schramm, D.

2017-10-01

This paper presents a data-driven approach to Condition Monitoring of Electromagnetic brakes without use of additional sensors. For safe and efficient operation of electric motor a regular evaluation and replacement of the friction surface of the brake is required. One such evaluation method consists of direct or indirect sensing of the air-gap between pressure plate and magnet. A larger gap is generally indicative of worn surface(s). Traditionally this has been accomplished by the use of additional sensors - making existing systems complex, cost- sensitive and difficult to maintain. In this work a feed-forward Artificial Neural Network (ANN) is learned with the electrical data of the brake by supervised learning method to estimate the air-gap. The ANN model is optimized on the training set and validated using the test set. The experimental results of estimated air-gap with accuracy of over 95% demonstrate the validity of the proposed approach.

Optimized Baking of the DIII-D Vessel

DOE Office of Scientific and Technical Information (OSTI.GOV)

P.M. Anderson; A.G. Kellman

The DIII-D tokamak vacuum vessel baking system is used to heat the vessel walls and internal hardware to an average temperature of 350 C to allow rapid conditioning of the vacuum surfaces. The system combines inductive heating and a circulating hot air system to provide rapid heating with temperature uniformity required by stress considerations. In recent years, the time to reach 350 C had increased from 9 hrs to 14 hrs. To understand and remedy this sluggish heating rate, an evaluation of the baking system was recently performed. The evaluation indicated that the mass of additional in-vessel hardware (50% increasemore » in mass) was primarily responsible. This paper reports on this analysis and the results of the addition of an electric air heater and procedural changes that have been implemented. Preliminary results indicate that the time to 350 C has been decreased to 4.5 hours and the temperature uniformity has improved.« less

Evaluating the impact and costs of deploying an electronic medical record system to support TB treatment in Peru

PubMed Central

Fraser, Hamish SF; Blaya, Joaquin; Choi, Sharon S; Bonilla, Cesar; Jazayeri, Darius

2006-01-01

The PIH-EMR is a Web based electronic medical record that has been in operation for over four years in Peru supporting the treatment of drug resistant TB. We describe here the types of evaluations that have been performed on the EMR to assess its impact on patient care, reporting, logistics and observational research. Formal studies have been performed on components for drug order entry, drug requirements prediction tools and the use of PDAs to collect bacteriology data. In addition less formal data on the use of the EMR for reporting and research are reviewed. Experience and insights from porting the PIH-EMR to the Philippines, and modifying it to support HIV treatment in Haiti and Rwanda are discussed. We propose that additional data of this sort is valuable in assessing medical information systems especially in resource poor areas. PMID:17238344

Evaluating the impact and costs of deploying an electronic medical record system to support TB treatment in Peru.

PubMed

Fraser, Hamish S F; Blaya, Joaquin; Choi, Sharon S; Bonilla, Cesar; Jazayeri, Darius

2006-01-01

The PIH-EMR is a Web based electronic medical record that has been in operation for over four years in Peru supporting the treatment of drug resistant TB. We describe here the types of evaluations that have been performed on the EMR to assess its impact on patient care, reporting, logistics and observational research. Formal studies have been performed on components for drug order entry, drug requirements prediction tools and the use of PDAs to collect bacteriology data. In addition less formal data on the use of the EMR for reporting and research are reviewed. Experience and insights from porting the PIH-EMR to the Philippines, and modifying it to support HIV treatment in Haiti and Rwanda are discussed. We propose that additional data of this sort is valuable in assessing medical information systems especially in resource poor areas.

Survivability of soldered leadless chip carriers after temperature cycling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zawicki, L.R.; Lenhardt, B.W.; Smith, F.R.

Temperature cycling evaluations were conducted on leadless chip carriers (LCCs) soldered to thick film networks (TKNs). Various temperature ranges, rates of change, cycle times, number of cycles, and sizes of LCCs were used. The TKNs were attached to metal backing plates with 63Sn/37Pb solder preforms using an infrared vacuum soldering process. The LCCs were attached to Pt/Au TKNs with 63Sn/37Pb solder paste using a belt reflow process. Visual examination and cross-sectional analysis were used to evaluate the survivability. Results were also correlated with finite elemental analysis. Considering the initial results, possible solutions included changing the solder from 63Sn/37Pb to 50Pb/50In,more » deleting the metal backplate, changing the rate of change in the temperature cycle, and/or adding leads to the large LCCs. Because of a system requirement, the rate of change in the temperature cycle could not be changed. Since there was no long term reliability information on the Pt/Au TKN with 50Pb/50In solder, this option was also dropped. Additional evaluations showed little difference in the survivability of large LCC solder joints with or without the metal backing plate. The final results indicated that LCCs beyond a certain physical size required compliant leads to survive the temperature cycle requirements.« less

10 CFR 830 Major Modification Determination for the ATR Diesel Bus (E-3) and Switchgear Replacement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Noel Duckwtiz

2011-05-01

Near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project, subject of this determination, will replace the existent diesel-electrical bus (E-3) and associated switchgear. More specifically, INL proposes transitioning ATR to 100% commercial power with appropriate emergency backup to include: • Provide commercial power as the normal source of power to the ATR loads currently supplied by diesel-electric power. •more » Provide backup power to the critical ATR loads in the event of a loss of commercial power. • Replace obsolescent critical ATR power distribution equipment, e.g., switchgear, transformers, motor control centers, distribution panels. Completion of this and two other age-related projects (primary coolant pump and motor replacement and emergency firewater injection system replacement) will resolve major age related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues make the project a major modification: 1. Evaluation Criteria #2 (Footprint change). The addition of a new PC-4 structure to the ATR Facility to house safety-related SSCs requires careful attention to maintaining adherence to applicable engineering and nuclear safety design criteria (e.g., structural qualification, fire suppression) to ensure no adverse impacts to the safety-related functions of the housed equipment. 2. Evaluation Criteria #3 (Change of existing process). The change to the strategy for providing continuous reliable power to the safety-related emergency coolant pumps requires careful attention and analysis to ensure it meets a project primary object to maintain or reduce CDF and does not negatively affect the efficacy of the currently approved strategy. 3. Evaluation Criteria #5 (Create the need for new or revised safety SSCs). The change to the strategy for providing continuous reliable power to the safety-related emergency coolant pumps, based on the pre-conceptual design, will require the addition of two quick start diesel generators, their associated power coordination/distribution controls, and a UPS to the list of safety-related SSCs. Similarly to item 1 above, the addition of these active SSCs to the list of safety-related SSCs and replacement of the E-3 bus requires careful attention to maintaining adherence to applicable engineering and nuclear safety design criteria (e.g., seismic qualification, isolation of redundant trains from common fault failures) to ensure no adverse impacts to the safety-related functions.« less

Radiologic Assessment of Patellofemoral Pain in the Athlete

PubMed Central

Endo, Yoshimi; Stein, Beth E. Shubin; Potter, Hollis G.

2011-01-01

Context: Although disorders of the patellofemoral joint are common in the athlete, their management can be challenging and require a thorough physical examination and radiologic evaluation, including advanced magnetic resonance imaging techniques. Evidence Acquisition: Relevant articles were searched under OVID and MEDLINE (1968 to 2010) using the keywords patellofemoral joint, patellofemoral pain or patella and radiography, imaging, or magnetic resonance imaging, and the referenced sources were reviewed for additional articles. The quality and validity of the studies were assessed on the basis of careful analysis of the materials and methods before their inclusion in this article. Results: Physical examination and imaging evaluation including standard radiographs are crucial in identifying evidence of malalignment or instability. Magnetic resonance imaging provides valuable information about concomitant soft tissue injuries to the medial stabilizers as well as injuries to the articular cartilage, including chondral shears and osteochondral fractures. Quantitative magnetic resonance imaging assessing the ultrastructure of cartilage has shown high correlation with histology and may be useful for timing surgery. Conclusions: Evaluation of patellofemoral disorders is complex and requires a comprehensive assessment. Recent advancements in imaging have made possible a more precise evaluation of the individual anatomy of the patient, addressing issues of malalignment, instability, and underlying cartilage damage. PMID:23016009

10 CFR 55.7 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition to...

10 CFR 55.7 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition to...

[Training 5th-Year Clinical Pharmacy Students to Collect and Evaluate Information from Original Articles].

PubMed

Esumi, Satoru; Kawasaki, Yoichi; Ida, Hiromi; Kitamura, Yoshihisa; Sendo, Toshiaki

2018-01-01

　Pharmacists are required to contribute to evidence-based medicine (EBM) by providing drug information, which can be collected from various sources such as books, websites, and original articles. In particular, information from original articles is needed in some situations. For example, original articles by international researchers are used to aid the management of novel in-hospital preparations on which little knowledge is available. We introduced an information evaluation program, the Okayama University Hospital EBM Model, into the clinical training of 5th-year pharmacy students. It aims to enable students to evaluate the validity of novel in-hospital preparations using original articles. This program has improved students' knowledge of EBM, and the satisfaction level of those enrolled was high. In addition, customer satisfaction analysis revealed that the overall degree of student satisfaction was related to their understanding of the necessity for EBM and the difficulty of practical training. In addition, students' achievements were evaluated using rubrics, and that method allowed the achievements of each student to be assessed appropriately. We hope to revise this program with the aim of improving students' understanding of EBM.

Headspace-Solid-Phase Microextraction-Gas Chromatography as Analytical Methodology for the Determination of Volatiles in Wild Mushrooms and Evaluation of Modifications Occurring during Storage

PubMed Central

Costa, Rosaria; De Grazia, Selenia; Grasso, Elisa; Trozzi, Alessandra

2015-01-01

Mushrooms are sources of food, medicines, and agricultural means. Not much is reported in the literature about wild species of the Mediterranean flora, although many of them are traditionally collected for human consumption. The knowledge of their chemical constituents could represent a valid tool for both taxonomic and physiological characterizations. In this work, a headspace-solid-phase microextraction (HS-SPME) method coupled with GC-MS and GC-FID was developed to evaluate the volatile profiles of ten wild mushroom species collected in South Italy. In addition, in order to evaluate the potential of this analytical methodology for true quantitation of volatiles, samples of the cultivated species Agaricus bisporus were analyzed. The choice of this mushroom was dictated by its ease of availability in the food market, due to the consistent amounts required for SPME method development. For calibration of the main volatile compounds, the standard addition method was chosen. Finally, the assessed volatile composition of A. bisporus was monitored in order to evaluate compositional changes occurring during storage, which represents a relevant issue for such a wide consumption edible product. PMID:25945282

Constructive evaluation: a pedagogy of student-contributed assessment

NASA Astrophysics Data System (ADS)

Luxton-Reilly, Andrew; Denny, Paul

2010-06-01

We present an innovative pedagogical approach that we call constructive evaluation, which shifts students from being consumers of knowledge to participants in a community of peers engaged in actively producing and sharing knowledge. Students are required to author a question that assesses one or more of the learning outcomes of a course. In addition to the question, students write a sample solution. These questions and solutions are stored in a question item bank where they become available for other students to use as a learning resource. Once a student answers a question from the item bank, they can see how other students have answered the question and can reflect on their own response. Additionally, students must review the questions they have answered and are given an opportunity to engage in discussion of questions or answers via a feedback mechanism. In addition to improving content knowledge, students develop important meta-skills such as organising and communicating knowledge; judging the quality of information; giving and receiving feedback and improving self-assessment skills. This approach is aligned with both reflective professional practice and social theories of learning.

The Effects of Adding Elements of Zinc and Magnesium on Ag-Cu Eutectic Alloy for Warming Acupuncture

PubMed Central

Park, Il Song; Kim, Keun Sik; Lee, Min Ho

2013-01-01

The warming acupuncture for hyperthermia therapy is made of STS304. However, its needle point cannot be reached to a desirable temperature due to heat loss caused by low thermal conductivity, and the quantification of stimulation condition and the effective standard establishment of warming acupuncture are required as a heat source. Accordingly, in this study, after Ag-Cu alloys with different composition ratios were casted and then mixed with additives to improve their physical and mechanical properties, the thermal conductivity and biocompatibility of the alloy specimens were evaluated for selecting suitable material. Ag-Cu binary alloys and ternary alloys added 5 wt% Zn or 2 wt% Mg were casted and then cold drawn to manufacture needles for acupuncture, and their physical properties, thermal conductivity, and biocompatibility were evaluated for their potential use in warming acupuncture. The results of this study showed that the physical and mechanical properties of the Ag-Cu alloys were improved by additives and that the thermal conductivity, machinability, and biocompatibility of the Ag-Cu alloys were improved by Mg addition. PMID:24078827

The effects of adding elements of zinc and magnesium on ag-cu eutectic alloy for warming acupuncture.

PubMed

Kim, Yu Kyoung; Park, Il Song; Kim, Keun Sik; Lee, Min Ho

2013-01-01

The warming acupuncture for hyperthermia therapy is made of STS304. However, its needle point cannot be reached to a desirable temperature due to heat loss caused by low thermal conductivity, and the quantification of stimulation condition and the effective standard establishment of warming acupuncture are required as a heat source. Accordingly, in this study, after Ag-Cu alloys with different composition ratios were casted and then mixed with additives to improve their physical and mechanical properties, the thermal conductivity and biocompatibility of the alloy specimens were evaluated for selecting suitable material. Ag-Cu binary alloys and ternary alloys added 5 wt% Zn or 2 wt% Mg were casted and then cold drawn to manufacture needles for acupuncture, and their physical properties, thermal conductivity, and biocompatibility were evaluated for their potential use in warming acupuncture. The results of this study showed that the physical and mechanical properties of the Ag-Cu alloys were improved by additives and that the thermal conductivity, machinability, and biocompatibility of the Ag-Cu alloys were improved by Mg addition.

Tier One Performance Screen Initial Operational Test and Evaluation: Early Results

DTIC Science & Technology

2011-04-01

Requirement: In addition to educational, physical , and moral screens, the U.S. Army relies on a composite score from the Armed Services Vocational Aptitude...analyses suggest that the individual TAPAS scales significantly predict a number of criteria of interest. Most notably, the Physical Conditioning scale...predicted Soldiers’ self-reported Army Physical Fitness Test (APFT) scores, number of restarts in training, adjustment to Army life, and 3-month

[Research in space environmental medicine: review and future].

PubMed

Yu, Xue-jun; Qi, Zhang-nian; Chang, Shao-yong; Liang, Hong; Liu, Hong-tao

2003-01-01

The investigation progress of space environmental medicine in China is summarized. Then, the application of space environmental medicine to formulating medical requirements for the crew module design, and performing medical evaluation for Shenzhou spaceship are addressed. Additionally, the medical and engineering means for the protection from harmful agents during spaceflight is illustrated. Finally, the objective and challenge of space environment medicine faced in the future research in China are presented.

Low Cost Fiber Optic Cable Assemblies for Local Distribution Systems

DTIC Science & Technology

1977-04-01

coefficient of friction, and is chemically inert. PFA exhibits low water permeability and ab- sorption . FEP-100 and FEP-110 were initially extruded over T08...with FEP 110. To overcome these problems, Teflon PFA 9704 was evaluated. It exhibited good extrudability which allowed application of thin and thick...superior extrudability, in addition to meeting the optical characteristics required for a cladding material, Teflon PFA was considered a viable

Ballistic Evaluation of 6055 Aluminum

DTIC Science & Technology

2015-09-01

impacts from various munitions including armor-piercing (AP) and fragment-simulating projectiles (FSPs). Additionally, Table 2 provides the required...percentage of the combination of silicon and iron cannot exceed 0.40%. 2. Experimental Procedure The V50 is defined as the impact velocity at which...152 mm (6 inches) behind the target to determine the outcome of each shot. An impact is regarded as a complete penetration (CP), or loss, if the

Predicting Attack-Prone Components with Source Code Static Analyzers

DTIC Science & Technology

2009-05-01

models to determine if additional metrics are required to increase the accuracy of the model: non-security SCSA warnings, code churn and size, the count...code churn and size, the count of faults found manually during development, and the measure of coupling between components. The dependent variable...is the count of vulnerabilities reported by testing and those found in the field. We evaluated our model on three commercial telecommunications

Institutional Challenges to Developing Metrics of Success in Irregular Warfare

DTIC Science & Technology

2011-12-01

more resources applied to a conflict require a larger military organization to manage and utilize the resources. Additionally, the culture of the...organizational culture closely resembles a “machine bureaucracy,” that is, primarily focused on the internal efficiency of the system and is more...evaluating the effects of their activities. Finally, from the effects of national imperative, the culture of the military organization, and the

Metrics for Offline Evaluation of Prognostic Performance

NASA Technical Reports Server (NTRS)

Saxena, Abhinav; Celaya, Jose; Saha, Bhaskar; Saha, Sankalita; Goebel, Kai

2010-01-01

Prognostic performance evaluation has gained significant attention in the past few years. Currently, prognostics concepts lack standard definitions and suffer from ambiguous and inconsistent interpretations. This lack of standards is in part due to the varied end-user requirements for different applications, time scales, available information, domain dynamics, etc. to name a few. The research community has used a variety of metrics largely based on convenience and their respective requirements. Very little attention has been focused on establishing a standardized approach to compare different efforts. This paper presents several new evaluation metrics tailored for prognostics that were recently introduced and were shown to effectively evaluate various algorithms as compared to other conventional metrics. Specifically, this paper presents a detailed discussion on how these metrics should be interpreted and used. These metrics have the capability of incorporating probabilistic uncertainty estimates from prognostic algorithms. In addition to quantitative assessment they also offer a comprehensive visual perspective that can be used in designing the prognostic system. Several methods are suggested to customize these metrics for different applications. Guidelines are provided to help choose one method over another based on distribution characteristics. Various issues faced by prognostics and its performance evaluation are discussed followed by a formal notational framework to help standardize subsequent developments.

Functional capacity evaluation of work performance among individuals with pelvic injuries following motor vehicle accidents.

PubMed

Ratzon, Navah Z; Ari Shevil, Eynat Ben; Froom, Paul; Friedman, Sharon; Amit, Yehuda

2013-01-01

Pelvic injuries following motor vehicle accidents (MVA) cause disability and affect work capabilities. This study evaluated functional, self-report, and medical-based factors that could predict work capacity as was reflected in a functional capacity evaluation (FCE) among persons who sustained a pelvic injury. It was hypothesized that self-reported functional status and bio-demographic variables would predict work capacity. Sixty-one community-dwelling adults previously hospitalized following a MVA induced pelvic injury. FCE for work performance was conducted using the Physical Work Performance Evaluation (PWPE). Additional data was collected through a demographics questionnaire and the Functional Status Questionnaire. All participants underwent an orthopedic medical examination of the hip and lower extremities. Most participants self-reported that their work capacity post-injury were lower than their job required. PWPE scores indicated below-range functional performance. Regression models predicted 23% to 51% of PWPE subtests. Participants' self-report of functioning (instrumental activities of daily living and work) and bio-demographic variables (gender and age) were better predictors of PWPE scores than factors originating from the medical examination. Results support the inclusion of FCE, in addition to self-report of functioning and medical examination, to evaluate work capacity among individuals' post-pelvic injury and interventions and discharge planning.

Evaluation of metal removal efficiency and its influence in the physicochemical parameters at two sewage treatment plants.

PubMed

Pipi, Angelo R F; Magdalena, Aroldo G; Giafferis, Giselda P; da Silva, Gustavo H R; Piacenti-Silva, Marina

2018-04-03

In sewage treatment plants, physicochemical parameters are highly controlled since treated sewage can be returned to water bodies or reused. In addition, pollutants such as heavy metals also deserve attention due to their potential toxicity. In general, these characteristics of sewage and treated water are evaluated independently, with the support of Brazilian legislation that does not require a routine for the analysis of metals as frequent as for the physicochemical parameters. In this work, 66 samples of raw sewage, treated sewage, and effluents from two treatment plants in the city of Bauru, São Paulo, Brazil, were evaluated to assess the efficiency of the treatment plants in the removal of metals. In addition, the influence of these pollutants on the quantification of physicochemical parameters was evaluated. The quantification of metals was performed using inductively coupled plasma optical spectroscopy (ICP-OES), and Spearman's test was applied to evaluate correlation between physicochemical parameters and metal content. The main metals found in the samples were Ba, Mn, Zn, Cu, Se, Fe, and Al. The results indicate that concentrations of metals in the aquatic environment can significantly affect the physicochemical parameters, since high concentrations of metals can interfere mainly in the pH, chemical oxygen demand, and dissolved oxygen.

Post-Closure Report for Closed Resource Conservation and Recovery Act Corrective Action Units, Nevada National Security Site, Nevada: For Calendar Year 2017, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matthews, Patrick; Alvarado, Juan

This report serves as the combined annual report for post-closure activities for the following closed corrective action units (CAUs): CAU 90, Area 2 Bitcutter Containment CAU 91, Area 3 U-3fi Injection Well CAU 92, Area 6 Decon Pond Facility CAU 110, Area 3 WMD U-3ax/bl Crater CAU 111, Area 5 WMD Retired Mixed Waste Pits CAU 112, Area 23 Hazardous Waste Trenches The results of the inspections, a summary of maintenance activities, and an evaluation of monitoring data are presented in this report. Site inspections are conducted annually at CAUs 90, 91, and 112; semiannually at CAUs 92 and 110;more » and quarterly at CAU 111. Additional inspections are conducted at CAU 92 if precipitation occurs in excess of 1.0 inches in a 24-hour period and at CAU 111 if precipitation occurs in excess of 1.0 inch in a 24-hour period. Inspections include an evaluation of the condition of the units, including covers, fences, signs, gates, and locks. At CAU 110, soil moisture monitoring, vegetation evaluations, and subsidence surveys are conducted in addition to the visual inspections. At CAU 111, soil moisture monitoring, vegetation evaluations, subsidence surveys, direct radiation monitoring, air monitoring, radon flux monitoring, and groundwater monitoring are conducted. This report will address all monitoring items notes above except groundwater monitoring. Groundwater monitoring is documented in the Nevada National Security Site Data Report: Groundwater Monitoring Program Area 5 Radioactive Waste Management Site. All required inspections, maintenance, and monitoring were conducted in accordance with the post-closure requirements of the permit. Revision 4 of Permit NEV HW0101 was issued effective December 10, 2015, and remains in effect until December 10, 2020.« less

[Requirements for the provision of healthcare to socially disadvantaged population groups: evaluation of 10 years of medical care provided to the homeless in Hanover].

PubMed

Meidl, Jana; Wenzlaff, Paul; Sens, Brigitte; Goesmann, Cornelia

2012-01-01

In 2007, the German Federal Government introduced a general health insurance obligation, but there are still vulnerable groups such as poor and homeless people without access to medical care. Especially for social fringe groups, a visit to the doctor involves many obstacles. Ten years ago the project "Outreach medical care for homeless people and people threatened by homelessness in Hanover" was established in order to reduce those gaps in healthcare provision. A continuously conducted evaluation of the project shows that low-threshold consulting hours are accepted and the transition to medical specialists is becoming increasingly easy. So the evaluation plays an important part in the development of the project. Since the healthcare reform in 2004, however, the number of cases has increased by 30 % while the actual homeless target group has remained the same. In order to guarantee access to the healthcare system for patients who cannot afford additional payments, the abolition of the quarterly practice fee and other additional payments for people on a low income is an important step. The growing requirements, resulting from a changing clientele and changes in the general conditions, are raising questions as to the nature of such projects and its future funding. In the long run it isn't the aim of this non-profit project to take on central tasks of a mutually supportive community. Therefore the data and results collected on the evaluation not only serve to improve the projects management, but also provide important information to other initiatives outside Hanover whether and how to support the respective groups of patients. Copyright © 2012. Published by Elsevier GmbH.

Revision of Import and Export Requirements for Controlled Substances, Listed Chemicals, and Tableting and Encapsulating Machines, Including Changes To Implement the International Trade Data System (ITDS); Revision of Reporting Requirements for Domestic Transactions in Listed Chemicals and Tableting and Encapsulating Machines; and Technical Amendments. Final rule.

PubMed

2016-12-30

The Drug Enforcement Administration is updating its regulations for the import and export of tableting and encapsulating machines, controlled substances, and listed chemicals, and its regulations relating to reports required for domestic transactions in listed chemicals, gamma-hydroxybutyric acid, and tableting and encapsulating machines. In accordance with Executive Order 13563, the Drug Enforcement Administration has reviewed its import and export regulations and reporting requirements for domestic transactions in listed chemicals (and gamma-hydroxybutyric acid) and tableting and encapsulating machines, and evaluated them for clarity, consistency, continued accuracy, and effectiveness. The amendments clarify certain policies and reflect current procedures and technological advancements. The amendments also allow for the implementation, as applicable to tableting and encapsulating machines, controlled substances, and listed chemicals, of the President's Executive Order 13659 on streamlining the export/import process and requiring the government-wide utilization of the International Trade Data System (ITDS). This rule additionally contains amendments that implement recent changes to the Controlled Substances Import and Export Act (CSIEA) for reexportation of controlled substances among members of the European Economic Area made by the Improving Regulatory Transparency for New Medical Therapies Act. The rule also includes additional substantive and technical and stylistic amendments.

Human Protein and Amino Acid Requirements.

PubMed

Hoffer, L John

2016-05-01

Human protein and amino acid nutrition encompasses a wide, complex, frequently misunderstood, and often contentious area of clinical research and practice. This tutorial explains the basic biochemical and physiologic principles that underlie our current understanding of protein and amino acid nutrition. The following topics are discussed: (1) the identity, measurement, and essentiality of nutritional proteins; (2) the definition and determination of minimum requirements; (3) nutrition adaptation; (4) obligatory nitrogen excretion and the minimum protein requirement; (5) minimum versus optimum protein intakes; (6) metabolic responses to surfeit and deficient protein intakes; (7) body composition and protein requirements; (8) labile protein; (9) N balance; (10) the principles of protein and amino acid turnover, including an analysis of the controversial indicator amino acid oxidation technique; (11) general guidelines for evaluating protein turnover articles; (12) amino acid turnover versus clearance; (13) the protein content of hydrated amino acid solutions; (14) protein requirements in special situations, including protein-catabolic critical illness; (15) amino acid supplements and additives, including monosodium glutamate and glutamine; and (16) a perspective on the future of protein and amino acid nutrition research. In addition to providing practical information, this tutorial aims to demonstrate the importance of rigorous physiologic reasoning, stimulate intellectual curiosity, and encourage fresh ideas in this dynamic area of human nutrition. In general, references are provided only for topics that are not well covered in modern textbooks. © 2016 American Society for Parenteral and Enteral Nutrition.

EURRECA-Estimating vitamin D requirements for deriving dietary reference values.

PubMed

Cashman, Kevin D; Kiely, Mairead

2013-01-01

The time course of the EURRECA from 2008 to 2012, overlapped considerably with the timeframe of the process undertaken by the North American Institute of Medicine (IOM) to revise dietary reference intakes for vitamin D and calcium (published November 2010). Therefore the aims of the vitamin D-related activities in EURRECA were formulated to address knowledge requirements that would complement the activities undertaken by the IOM and provide additional resources for risk assessors and risk management agencies charged with the task of setting dietary reference values for vitamin D. A total of three systematic reviews were carried out. The first, which pre-dated the IOM review process, identified and evaluated existing and novel biomarkers of vitamin D status and confirmed that circulating 25-hydroxyvitamin D (25(OH)D) concentrations is a robust and reliable marker of vitamin D status. The second systematic review conducted a meta-analysis of the dose-response of serum 25(OH)D to vitamin D intake from randomized controlled trials (RCT) among adults to explore the most appropriate model of the vitamin D intake-serum 25(OH)D) relationship to estimate requirements. The third review also carried out a meta-analysis to evaluate evidence of efficacy from RCT using foods fortified with vitamin D, and found they increased circulating 25(OH)D concentrations in a dose-dependent manner but identified a need for stronger data on the efficacy of vitamin D-fortified food on deficiency prevention and potential health outcomes, including adverse effects. Finally, narrative reviews provided estimates of the prevalence of inadequate intakes of vitamin D in adults and children from international dietary surveys, as well as a compilation of research requirements for vitamin D to inform current and future assessments of vitamin D requirements. [Supplementary materials are available for this article. Go to the publisher's onilne edition of Critical Reviews in Food Science and Nutrion for the following free supplemental files: Additional text, tables, and figures.].

Experimental demonstration of OpenFlow-enabled media ecosystem architecture for high-end applications over metro and core networks.

PubMed

Ntofon, Okung-Dike; Channegowda, Mayur P; Efstathiou, Nikolaos; Rashidi Fard, Mehdi; Nejabati, Reza; Hunter, David K; Simeonidou, Dimitra

2013-02-25

In this paper, a novel Software-Defined Networking (SDN) architecture is proposed for high-end Ultra High Definition (UHD) media applications. UHD media applications require huge amounts of bandwidth that can only be met with high-capacity optical networks. In addition, there are requirements for control frameworks capable of delivering effective application performance with efficient network utilization. A novel SDN-based Controller that tightly integrates application-awareness with network control and management is proposed for such applications. An OpenFlow-enabled test-bed demonstrator is reported with performance evaluations of advanced online and offline media- and network-aware schedulers.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goins, Bobby

A systems based approach will be used to evaluate the nitrogen delivery process. This approach involves principles found in Lean, Reliability, Systems Thinking, and Requirements. This unique combination of principles and thought process yields a very in depth look into the system to which it is applied. By applying a systems based approach to the nitrogen delivery process there should be improvements in cycle time, efficiency, and a reduction in the required number of personnel needed to sustain the delivery process. This will in turn reduce the amount of demurrage charges that the site incurs. In addition there should bemore » less frustration associated with the delivery process.« less

A Systems Approach to Nitrogen Delivery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goins, Bobby

A systems based approach will be used to evaluate the nitrogen delivery process. This approach involves principles found in Lean, Reliability, Systems Thinking, and Requirements. This unique combination of principles and thought process yields a very in depth look into the system to which it is applied. By applying a systems based approach to the nitrogen delivery process there should be improvements in cycle time, efficiency, and a reduction in the required number of personnel needed to sustain the delivery process. This will in turn reduce the amount of demurrage charges that the site incurs. In addition there should bemore » less frustration associated with the delivery process.« less

Usability evaluation of the digital anger thermometer app.

PubMed

Mattson, Donald C

2017-09-01

The digital anger thermometer is a prototype for a mobile application (app) for use with adults in anger management treatment. The digital anger thermometer incorporates standards of software development in addition to anger management resources from the Substance Abuse and Mental Health Services Administration. The digital anger thermometer underwent a usability study conducted by five expert reviewers. The results indicate that it is easy to learn, efficient, and ergonomically sound. However, it does not offer support features or user-error tolerance. The digital anger thermometer prototype requires additional usability studies and comparative research in order for it to become an actual mental health app.

Cancer-targeted therapies and radiopharmaceuticals

PubMed Central

Rachner, Tilman D; Jakob, Franz; Hofbauer, Lorenz C

2015-01-01

The treatment of bone metastases remains a clinical challenge. Although a number of well-established agents, namely bisphosphonates and denosumab, are available to reduce the occurrence of skeletal-related events, additional cancer-targeted therapies are required to improve patients' prognosis and quality of life. This review focuses on novel targets and agents that are under clinical evaluation for the treatment of malignant bone diseases such as activin A, src and endothelin-1 inhibition or agents that are clinically approved and may positively influence bone, such as the mTOR inhibitor everolimus. In addition, the potential of alpharadin, a novel radiopharmaceutical approved for the treatment of prostatic bone disease, is discussed. PMID:26131359

CT image segmentation methods for bone used in medical additive manufacturing.

PubMed

van Eijnatten, Maureen; van Dijk, Roelof; Dobbe, Johannes; Streekstra, Geert; Koivisto, Juha; Wolff, Jan

2018-01-01

The accuracy of additive manufactured medical constructs is limited by errors introduced during image segmentation. The aim of this study was to review the existing literature on different image segmentation methods used in medical additive manufacturing. Thirty-two publications that reported on the accuracy of bone segmentation based on computed tomography images were identified using PubMed, ScienceDirect, Scopus, and Google Scholar. The advantages and disadvantages of the different segmentation methods used in these studies were evaluated and reported accuracies were compared. The spread between the reported accuracies was large (0.04 mm - 1.9 mm). Global thresholding was the most commonly used segmentation method with accuracies under 0.6 mm. The disadvantage of this method is the extensive manual post-processing required. Advanced thresholding methods could improve the accuracy to under 0.38 mm. However, such methods are currently not included in commercial software packages. Statistical shape model methods resulted in accuracies from 0.25 mm to 1.9 mm but are only suitable for anatomical structures with moderate anatomical variations. Thresholding remains the most widely used segmentation method in medical additive manufacturing. To improve the accuracy and reduce the costs of patient-specific additive manufactured constructs, more advanced segmentation methods are required. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

[Antibiotic consumption surveillance - state of implementation in Munich hospitals : Latest survey by the Munich public health department on the implementation of § 23 Infection protection act].

PubMed

Otto, Cornelia; Hirl, Bertrand; Schweitzer, Stefan; Gleich, Sabine

2016-12-01

On 4 August 2011 a modification of the infection protection act became law, meaning that antibiotic consumption surveillance and evaluation of data on the local resistance situation became obligatory for hospitals. Four years after the modification of the infection protection act became law, the Munich public health department aimed to evaluate the state of implementation of antibiotic consumption surveillance in Munich hospitals and to ascertain which antibiotic stewardship (ABS) structures have already been established. A questionnaire was sent to Munich hospitals about their antibiotic management structural data and state of implementation of legal requirements. Only 32 % of the hospitals have qualified ABS-experts available. In 76 % of the hospitals persons responsible for antibiotic consumption surveillance are appointed, while in 12 % persons responsible for antibiotic consumption surveillance are at least partly released from their normal work for this activity. Twenty-one hospitals (21 %) conduct antibiotic consumption surveillance taking into account all antiinfective agents mentioned in the Robert Koch-Institute (RKI) guidelines. Of these, 19 (76 %) did this on basis of World Health Organizations ATC/DDD-system (anatomical therapeutic chemical [ATC] classification system which uses defined daily doses [DDD]). The data on antibiotic consumption is evaluated in 72 % of the hospitals, 68 % take account of the local resistance situation. In 96 %, in-house lists of antiinfectives are available; in 80 %, in-house guidelines for antibiotic treatment are available. Fourty-four percent of the hospitals take part in a national surveillance. For the first time data were collected on implementation of antibiotic consumption surveillance in hospitals, which has been required by law since 2011. An incomplete implementation of legal requirements was demonstrated. It was found that structural and personnel prerequisites are often missing, that release from normal work for this additional duty is rarely granted and that the evaluation of data is often either missing or does not correspond to the legal requirements by omitting to take account of the local resistance situation. The hygienic control of hospitals by the public health service was extended by an additional subject. To carry out this very specialized task in a competent way, an ABS-qualification for public health staff is essential from the perspective of the authors.

Evaluating imbalances of adverse events during biosimilar development

PubMed Central

Vana, Alicia M.; Freyman, Amy W.; Reich, Steven D.; Yin, Donghua; Li, Ruifeng; Anderson, Scott; Jacobs, Ira A.; Zacharchuk, Charles M.; Ewesuedo, Reginald

2016-01-01

ABSTRACT Biosimilars are designed to be highly similar to approved or licensed (reference) biologics and are evaluated based on the totality of evidence from extensive analytical, nonclinical and clinical studies. As part of the stepwise approach recommended by regulatory agencies, the first step in the clinical evaluation of biosimilarity is to conduct a pharmacokinetics similarity study in which the potential biosimilar is compared with the reference product. In the context of biosimilar development, a pharmacokinetics similarity study is not necessarily designed for a comparative assessment of safety. Development of PF-05280014, a potential biosimilar to trastuzumab, illustrates how a numerical imbalance in an adverse event in a small pharmacokinetics study can raise questions on safety that may require additional clinical trials. PMID:27050730

Specialized data analysis for the Space Shuttle Main Engine and diagnostic evaluation of advanced propulsion system components

NASA Technical Reports Server (NTRS)

1993-01-01

The Marshall Space Flight Center is responsible for the development and management of advanced launch vehicle propulsion systems, including the Space Shuttle Main Engine (SSME), which is presently operational, and the Space Transportation Main Engine (STME) under development. The SSME's provide high performance within stringent constraints on size, weight, and reliability. Based on operational experience, continuous design improvement is in progress to enhance system durability and reliability. Specialized data analysis and interpretation is required in support of SSME and advanced propulsion system diagnostic evaluations. Comprehensive evaluation of the dynamic measurements obtained from test and flight operations is necessary to provide timely assessment of the vibrational characteristics indicating the operational status of turbomachinery and other critical engine components. Efficient performance of this effort is critical due to the significant impact of dynamic evaluation results on ground test and launch schedules, and requires direct familiarity with SSME and derivative systems, test data acquisition, and diagnostic software. Detailed analysis and evaluation of dynamic measurements obtained during SSME and advanced system ground test and flight operations was performed including analytical/statistical assessment of component dynamic behavior, and the development and implementation of analytical/statistical models to efficiently define nominal component dynamic characteristics, detect anomalous behavior, and assess machinery operational condition. In addition, the SSME and J-2 data will be applied to develop vibroacoustic environments for advanced propulsion system components, as required. This study will provide timely assessment of engine component operational status, identify probable causes of malfunction, and indicate feasible engineering solutions. This contract will be performed through accomplishment of negotiated task orders.

Model-based Assessment for Balancing Privacy Requirements and Operational Capabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knirsch, Fabian; Engel, Dominik; Frincu, Marc

2015-02-17

The smart grid changes the way energy is produced and distributed. In addition both, energy and information is exchanged bidirectionally among participating parties. Therefore heterogeneous systems have to cooperate effectively in order to achieve a common high-level use case, such as smart metering for billing or demand response for load curtailment. Furthermore, a substantial amount of personal data is often needed for achieving that goal. Capturing and processing personal data in the smart grid increases customer concerns about privacy and in addition, certain statutory and operational requirements regarding privacy aware data processing and storage have to be met. An increasemore » of privacy constraints, however, often limits the operational capabilities of the system. In this paper, we present an approach that automates the process of finding an optimal balance between privacy requirements and operational requirements in a smart grid use case and application scenario. This is achieved by formally describing use cases in an abstract model and by finding an algorithm that determines the optimum balance by forward mapping privacy and operational impacts. For this optimal balancing algorithm both, a numeric approximation and – if feasible – an analytic assessment are presented and investigated. The system is evaluated by applying the tool to a real-world use case from the University of Southern California (USC) microgrid.« less

An Evaluation of the Additional Acoustic Power Needed to Overcome the Effects of a Test-Article's Absorption During Reverberant Chamber Acoustic Testing of Spaceflight Hardware

NASA Technical Reports Server (NTRS)

Hozman, Aron D.; Hughes, William O.

2014-01-01

The exposure of a customer's aerospace test-article to a simulated acoustic launch environment is typically performed in a reverberant acoustic test chamber. The acoustic pre-test runs that will ensure that the sound pressure levels of this environment can indeed be met by a test facility are normally performed without a test-article dynamic simulator of representative acoustic absorption and size. If an acoustic test facility's available acoustic power capability becomes maximized with the test-article installed during the actual test then the customer's environment requirement may become compromised. In order to understand the risk of not achieving the customer's in-tolerance spectrum requirement with the test-article installed, an acoustic power margin evaluation as a function of frequency may be performed by the test facility. The method for this evaluation of acoustic power will be discussed in this paper. This method was recently applied at the NASA Glenn Research Center Plum Brook Station's Reverberant Acoustic Test Facility for the SpaceX Falcon 9 Payload Fairing acoustic test program.

An Evaluation of the Additional Acoustic Power Needed to Overcome the Effects of a Test-Article's Absorption during Reverberant Chamber Acoustic Testing of Spaceflight Hardware

NASA Technical Reports Server (NTRS)

Hozman, Aron D.; Hughes, William O.

2014-01-01

The exposure of a customers aerospace test-article to a simulated acoustic launch environment is typically performed in a reverberant acoustic test chamber. The acoustic pre-test runs that will ensure that the sound pressure levels of this environment can indeed be met by a test facility are normally performed without a test-article dynamic simulator of representative acoustic absorption and size. If an acoustic test facilitys available acoustic power capability becomes maximized with the test-article installed during the actual test then the customers environment requirement may become compromised. In order to understand the risk of not achieving the customers in-tolerance spectrum requirement with the test-article installed, an acoustic power margin evaluation as a function of frequency may be performed by the test facility. The method for this evaluation of acoustic power will be discussed in this paper. This method was recently applied at the NASA Glenn Research Center Plum Brook Stations Reverberant Acoustic Test Facility for the SpaceX Falcon 9 Payload Fairing acoustic test program.

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

An evaluation on CT image acquisition method for medical VR applications

NASA Astrophysics Data System (ADS)

Jang, Seong-wook; Ko, Junho; Yoo, Yon-sik; Kim, Yoonsang

2017-02-01

Recent medical virtual reality (VR) applications to minimize re-operations are being studied for improvements in surgical efficiency and reduction of operation error. The CT image acquisition method considering three-dimensional (3D) modeling for medical VR applications is important, because the realistic model is required for the actual human organ. However, the research for medical VR applications has focused on 3D modeling techniques and utilized 3D models. In addition, research on a CT image acquisition method considering 3D modeling has never been reported. The conventional CT image acquisition method involves scanning a limited area of the lesion for the diagnosis of doctors once or twice. However, the medical VR application is required to acquire the CT image considering patients' various postures and a wider area than the lesion. A wider area than the lesion is required because of the necessary process of comparing bilateral sides for dyskinesia diagnosis of the shoulder, pelvis, and leg. Moreover, patients' various postures are required due to the different effects on the musculoskeletal system. Therefore, in this paper, we perform a comparative experiment on the acquired CT images considering image area (unilateral/bilateral) and patients' postures (neutral/abducted). CT images are acquired from 10 patients for the experiments, and the acquired CT images are evaluated based on the length per pixel and the morphological deviation. Finally, by comparing the experiment results, we evaluate the CT image acquisition method for medical VR applications.

Evaluation of solar sludge drying alternatives by costs and area requirements.

PubMed

Kurt, Mayıs; Aksoy, Ayşegül; Sanin, F Dilek

2015-10-01

Thermal drying is a common method to reach above 90% dry solids content (DS) in sludge. However, thermal drying requires high amount of energy and can be expensive. A greenhouse solar dryer (GSD) can be a cost-effective substitute if the drying performance, which is typically 70% DS, can be increased by additional heat. In this study feasibility of GSD supported with solar panels is evaluated as an alternative to thermal dryers to reach 90% DS. Evaluations are based on capital and O&M costs as well as area requirements for 37 wastewater treatment plants (WWTPs) with various sludge production rates. Costs for the supported GSD system are compared to that of conventional and co-generation thermal dryers. To calculate the optimal costs associated with the drying system, an optimization model was developed in which area limitation was a constraint. Results showed that total cost was minimum when the DS in the GSD (DS(m,i)) was equal to the maximum attainable value (70% DS). On average, 58% of the total cost and 38% of total required area were associated with the GSD. Variations in costs for 37 WWTPs were due to differences in initial DS (DS(i,i)) and sludge production rates, indicating the importance of dewatering to lower drying costs. For large plants, GSD supported with solar panels provided savings in total costs especially in long term when compared to conventional and co-generation thermal dryers. Copyright © 2015 Elsevier Ltd. All rights reserved.

Biorefinery Demonstration Project Final Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, David

2015-10-20

In this project we focused on various aspects of biorefinery technology development including algal-biorefinery technology, thermochemical conversion of biomass to bio-oils and biochar; we tested characteristics and applications of biochars and evaluated nutrient cycling with wastewater treatment by the coupling of algal culture systems and anaerobic digestion. Key results include a method for reducing water content of bio-oil through atomized alcohol addition. The effect included increasing the pH and reducing the viscosity and cloud point of the bio-oil. Low input biochar production systems were evaluated via literature reviews and direct experimental work. Additionally, emissions were evaluated and three biochar systemsmore » were compared via a life cycle analysis. Attached growth systems for both algal cultivation and algal harvesting were found to be superior to suspended growth cultures. Nutrient requirements for algal cultivation could be obtained by the recycling of anaerobic digester effluents, thus experimentally showing that these two systems could be directly coupled. Twenty-two journal articles and six intellectual property applications resulted from the cumulative work that this project contributed to programmatically.« less

Hydrophysical Evaluation of Wells TW-B, TW-7, UE-6d, U-2gg PSE 3A, U-10L 1, and UE-6e in Yucca Flat

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pohlmann, Karl; Healey, John; Lyles, Bred

This study evaluated six wells in Yucca Flat in support of the Underground Test Area (UGTA) Activity conducted by the U.S. Department of Energy (DOE) at the Nevada National Security Site (NNSS). Accessibility and groundwater sampling conditions were assessed and if conditions permitted, samples were collected for tritium analysis. Four of the wells, TW-B, UE-6d, UE-6e, and TW-7 were sampled in support of UGTA responses to recommendations made by the Yucca Flat/Climax Mine External Peer Review Committee (Navarro, 2016). In addition to its role in support of these responses, TW-7 was included because it is listed in the NNSS Integratedmore » Groundwater Sampling Plan (DOE, 2014) as a required sampling location, although it had not been sampled since 1994. U-2gg PSE 3A and U-10L 1 were evaluated to determine whether deteriorating well conditions can be addressed so that these wells can be used as additional sampling points in Yucca Flat.« less

A Modular, Reusable Latch and Decking System for Securing Payloads During Launch and Planetary Surface Transport

NASA Technical Reports Server (NTRS)

Doggett, William R.; Dorsey, John T.; Jones, Thomas C.; King, Bruce D.; Mikulas, Martin M.

2011-01-01

Efficient handling of payloads destined for a planetary surface, such as the moon or mars, requires robust systems to secure the payloads during transport on the ground, in space and on the planetary surface. In addition, mechanisms to release the payloads need to be reliable to ensure successful transfer from one vehicle to another. An efficient payload handling strategy must also consider the devices available to support payload handling. Cranes used for overhead lifting are common to all phases of payload handling on Earth. Similarly, both recent and past studies have demonstrated that devices with comparable functionality will be needed to support lunar outpost operations. A first generation test-bed of a new high performance device that provides the capabilities of both a crane and a robotic manipulator, the Lunar Surface Manipulation System (LSMS), has been designed, built and field tested and is available for use in evaluating a system to secure payloads to transportation vehicles. A payload handling approach must address all phases of payload management including: ground transportation, launch, planetary transfer and installation in the final system. In addition, storage may be required during any phase of operations. Each of these phases requires the payload to be lifted and secured to a vehicle, transported, released and lifted in preparation for the next transportation or storage phase. A critical component of a successful payload handling approach is a latch and associated carrier system. The latch and carrier system should minimize requirements on the: payload, carrier support structure and payload handling devices as well as be able to accommodate a wide range of payload sizes. In addition, the latch should; be small and lightweight, support a method to apply preload, be reusable, integrate into a minimal set of hard-points and have manual interfaces to actuate the latch should a problem occur. A latching system which meets these requirements has been designed and fabricated and will be described in detail. This latching system works in conjunction with a payload handling device such as the LSMS, and the LSMS has been used to test first generation latch and carrier hardware. All tests have been successful during the first phase of operational evaluations. Plans for future tests of first generation latch and carrier hardware with the LSMS are also described.

A Modular, Reusable Latch and Decking System for Securing Payloads During Launch and Planetary Surface Transport

NASA Technical Reports Server (NTRS)

Doggett, William R.; Dorsey, John T.; Jones, Thomas C.; King, Bruce D.; Mikulas, Martin M.

2010-01-01

Efficient handling of payloads destined for a planetary surface, such as the moon or Mars, requires robust systems to secure the payloads during transport on the ground, in-space and on the planetary surface. In addition, mechanisms to release the payloads need to be reliable to ensure successful transfer from one vehicle to another. An efficient payload handling strategy must also consider the devices available to support payload handling. Cranes used for overhead lifting are common to all phases of payload handling on Earth. Similarly, both recent and past studies have demonstrated that devices with comparable functionality will be needed to support lunar outpost operations. A first generation test-bed of a new high performance device that provides the capabilities of both a crane and a robotic manipulator, the Lunar Surface Manipulation System (LSMS), has been designed, built and field tested and is available for use in evaluating a system to secure payloads to transportation vehicles. National Institute of Aerospace, Hampton Va 23662 A payload handling approach must address all phases of payload management including: ground transportation, launch, planetary transfer and installation in the final system. In addition, storage may be required during any phase of operations. Each of these phases requires the payload to be lifted and secured to a vehicle, transported, released and lifted in preparation for the next transportation or storage phase. A critical component of a successful payload handling approach is a latch and associated carrier system. The latch and carrier system should minimize requirements on the: payload, carrier support structure and payload handling devices as well as be able to accommodate a wide range of payload sizes. In addition, the latch should; be small and lightweight, support a method to apply preload, be reusable, integrate into a minimal set of hard-points and have manual interfaces to actuate the latch should a problem occur. A latching system which meets these requirements has been designed and fabricated and will be described in detail. This latching system works in conjunction with a payload handling device such as the LSMS, and the LSMS has been used to test first generation latch and carrier hardware. All tests have been successful during the first phase of operational evaluations. Plans for future tests of first generation latch and carrier hardware with the LSMS are also described.

Evaluating hospitals' provision of community benefit: an argument for an outcome-based approach to nonprofit hospital tax exemption.

PubMed

Rubin, Daniel B; Singh, Simone Rauscher; Jacobson, Peter D

2013-04-01

Nonprofit hospitals are exempt from federal income taxation if they pass organizational and operational tests, including satisfying the community-benefit standard. Policymakers, however, have questioned the adequacy of the community benefits that nonprofit hospitals provide in exchange for these exemptions. The Internal Revenue Service recently responded to these concerns by redesigning its tax forms for nonprofit hospitals. The new Form 990 Schedule H requires nonprofit hospitals to provide additional information about their community-benefit activities. This new reporting requirement, however, places an undue focus on input-based community-benefit indicators, in particular expenditures. We argue that expanding the current input-based reporting requirement to include not only monetary inputs but also population health outcomes would achieve greater benefit for society.

Validation of sterilizing grade filtration.

PubMed

Jornitz, M W; Meltzer, T H

2003-01-01

Validation consideration of sterilizing grade filters, namely 0.2 micron, changed when FDA voiced concerns about the validity of Bacterial Challenge tests performed in the past. Such validation exercises are nowadays considered to be filter qualification. Filter validation requires more thorough analysis, especially Bacterial Challenge testing with the actual drug product under process conditions. To do so, viability testing is a necessity to determine the Bacterial Challenge test methodology. Additionally to these two compulsory tests, other evaluations like extractable, adsorption and chemical compatibility tests should be considered. PDA Technical Report # 26, Sterilizing Filtration of Liquids, describes all parameters and aspects required for the comprehensive validation of filters. The report is a most helpful tool for validation of liquid filters used in the biopharmaceutical industry. It sets the cornerstones of validation requirements and other filtration considerations.

Evaluating Hospitals’ Provision of Community Benefit: An Argument for an Outcome-Based Approach to Nonprofit Hospital Tax Exemption

PubMed Central

Singh, Simone Rauscher; Jacobson, Peter D.

2013-01-01

Nonprofit hospitals are exempt from federal income taxation if they pass organizational and operational tests, including satisfying the community-benefit standard. Policymakers, however, have questioned the adequacy of the community benefits that nonprofit hospitals provide in exchange for these exemptions. The Internal Revenue Service recently responded to these concerns by redesigning its tax forms for nonprofit hospitals. The new Form 990 Schedule H requires nonprofit hospitals to provide additional information about their community-benefit activities. This new reporting requirement, however, places an undue focus on input-based community-benefit indicators, in particular expenditures. We argue that expanding the current input-based reporting requirement to include not only monetary inputs but also population health outcomes would achieve greater benefit for society. PMID:23409909

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Additional survey requirements for steel-hull vessels...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42..., peaks, bilges, machinery spaces, and bunkers shall be examined to determine the condition of the framing...

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

Thermal Injuries in Veterinary Forensic Pathology.

PubMed

Wohlsein, P; Peters, M; Schulze, C; Baumgärtner, W

2016-09-01

Localized thermal injuries in animals may be caused by exposure to fire and radiant heat, contact with hot items including hot liquids or steam, inhalation of hot air, and exposure to cold temperatures. In addition, animal fire victims may have intoxications caused by smoke gas. This article reviews the causes, pathogenetic aspects, morphological findings, additional investigations, differential diagnoses, and causes of death in various forms of thermal injuries. Since these cases do not occur frequently in diagnostic pathology, they represent a challenging task in general but also with respect to forensic or criminal aspects, such as whether a lesion represents an accidental or nonaccidental effect. Besides detailed information about the circumstances at the location, thermal injuries in animals require a thorough morphological evaluation, including additional investigations in conjunction with a profound knowledge about the possible lesion spectrum and suitable additional investigations. © The Author(s) 2016.

40 CFR 80.1613 - Standards and other requirements for gasoline additive manufacturers and blenders.

Code of Federal Regulations, 2014 CFR

2014-07-01

... gasoline additive manufacturers and blenders. 80.1613 Section 80.1613 Protection of Environment... Gasoline Sulfur § 80.1613 Standards and other requirements for gasoline additive manufacturers and blenders. Gasoline additive manufacturers and blenders must meet the following requirements: (a) Gasoline additive...

Female athlete triad screening in National Collegiate Athletic Association Division I athletes: is the preparticipation evaluation form effective?

PubMed

Mencias, Tara; Noon, Megan; Hoch, Anne Z

2012-03-01

To evaluate the screening practices and preparticipation evaluation (PPE) forms used to identify college athletes at risk for the female athlete triad (triad). Phone and/or e-mail survey. National Collegiate Athletic Association (NCAA) Division I universities. All 347 NCAA Division I universities were invited to participate in a survey, with 257 participating in the survey (74%) and 287 forms collected (83%). Information about the nature of the PPE was requested from team physicians and certified athletic trainers during a phone or e-mail survey. In addition, a copy of their PPE form was requested to evaluate for inclusion of the 12 items recommended by the Female Athlete Triad Coalition for primary screening for the triad. All 257 universities (100%) required a PPE for incoming athletes; however, only 83 universities (32%) required an annual PPE for returning athletes. Screening was performed on campus at 218 universities (85%). Eleven universities (4%) were using the recently updated fourth edition PPE. Only 25 universities (9%) had 9 or more of the 12 recommended items included in their forms, whereas 127 universities (44%) included 4 or less items. Relevant items that were omitted from more than 40% of forms included losing weight to meet the image requirements of a sport; using vomiting, diuretics, and/or laxatives to lose weight; and the number of menses experienced in the past 12 months. The current PPE forms used by NCAA Division I universities may not effectively screen for the triad.

Diabetic retinopathy and complexity of retinal surgery in a general hospital.

PubMed

Mijangos-Medina, Laura Fanny; Hurtado-Noriega, Blanca Esmeralda; Lima-Gómez, Virgilio

2012-01-01

Usual retinal surgery (vitrectomy or surgery for retinal detachment) may require additional procedures to deal with complex cases, which increase time and resource use and delay access to treatment. We undertook this study to identify the proportion of primary retinal surgeries that required complex procedures and the associated causes. We carried out an observational, descriptive, cross-sectional, retrospective study. Patients with primary retinal surgery were evaluated (January 2007-December 2010). The proportion and 95% confidence intervals (CI) of preoperative diagnosis and cause of the disease requiring retinal surgery as well as the causes for complex retinal surgery were identified. Complex retinal surgery was defined as that requiring lens extraction, intraocular lens implantation, heavy perfluorocarbon liquids, silicone oil tamponade or intravitreal drugs, in addition to the usual surgical retinal procedure. The proportion of complex retinal surgeries was compared among preoperative diagnoses and among causes (χ(2), odds ratio [OR]). We studied 338 eyes. Mean age of subjects was 53.7 years, and there were 49% females. The most common diagnoses were vitreous hemorrhage (27.2%) and rhegmatogenous retinal detachment (24.6%). The most common cause was diabetes (50.6%); 273 eyes required complex surgery (80.8%, 95% CI: 76.6-85). The proportion did not differ among diagnoses but was higher in diabetic retinopathy (89%, p <0.001, OR 3.04, 95% CI: 1.63-5.7). Of the total sample, 80.8% of eyes required complex surgical procedures; diabetic retinopathy increased by 3-fold the probability of requiring these complex procedures. Early treatment of diabetic retinopathy may reduce the proportion of complex retinal surgery by 56%.

76 FR 64022 - Hydrogen Sulfide; Community Right-to-Know Toxic Chemical Release Reporting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

...EPA is announcing that it is lifting the Administrative Stay of the Emergency Planning and Community Right-to-Know Act (EPCRA) section 313 toxic chemical release reporting requirements for hydrogen sulfide (Chemical Abstracts Service Number (CAS No.) 7783-06-4). Hydrogen sulfide was added to the EPCRA section 313 list of toxic chemicals in a final rule published in the Federal Register on December 1, 1993. However, on August 22, 1994, EPA issued an Administrative Stay of the reporting requirements for hydrogen sulfide in order to evaluate issues brought to the Agency's attention after promulgation of the final rule concerning the human health effect basis for the listing and the Agency's use of exposure analysis in EPCRA section 313 listing decisions. Although the final rule listing hydrogen sulfide under section 313 of EPCRA remained in force, the stay deferred the reporting requirements for hydrogen sulfide while EPA completed this further evaluation. EPA completed its further evaluation of additional information that has become available since the stay was put in place regarding the human health and environmental effects of hydrogen sulfide, and the Agency published a position that the stay should be lifted in the February 26, 2010, Federal Register document ``Intent to Consider Lifting Administrative Stay; Opportunity for Public Comment.'' Based on EPA's further evaluation and the consideration of the public comments received on the notice of intent, EPA continues to believe that the Administrative Stay should be lifted. By this current action, EPA is not revisiting the original listing decision, which was accomplished by final rule on December 1, 1993. Rather, EPA is lifting the Administrative Stay of the reporting requirements for hydrogen sulfide.

A study on reliability of power customer in distribution network

NASA Astrophysics Data System (ADS)

Liu, Liyuan; Ouyang, Sen; Chen, Danling; Ma, Shaohua; Wang, Xin

2017-05-01

The existing power supply reliability index system is oriented to power system without considering actual electricity availability in customer side. In addition, it is unable to reflect outage or customer’s equipment shutdown caused by instantaneous interruption and power quality problem. This paper thus makes a systematic study on reliability of power customer. By comparing with power supply reliability, reliability of power customer is defined and extracted its evaluation requirements. An indexes system, consisting of seven customer indexes and two contrast indexes, are designed to describe reliability of power customer from continuity and availability. In order to comprehensively and quantitatively evaluate reliability of power customer in distribution networks, reliability evaluation method is proposed based on improved entropy method and the punishment weighting principle. Practical application has proved that reliability index system and evaluation method for power customer is reasonable and effective.

Combined effect of using near-infrared spectroscopy for nutritional evaluation of feed ingredients and non-starch polysaccharide carbohydrase complex on performance of broiler chickens.

PubMed

Montanhini Neto, Roberto; N'Guetta, Eric; Gady, Cecile; Francesch, Maria; Preynat, Aurélie

2017-12-01

This study was carried out to evaluate the combined effect of using near-infrared spectroscopy (NIRS) for nutritional evaluation of feed ingredients and the addition of non-starch polysaccharide carbohydrase complex (NSP enzymes) on the growth performance of broilers fed diets produced with low-quality wheat and soybean meal. A 2 × 2 trial design was performed, with seven replicates of 40 male Ross 308 broilers per treatment, evaluating the effect of the addition of NSP enzymes and the ingredients' nutritional matrix based on table values or NIRS values. Diets without added enzymes were formulated to reach nutritional requirements, whereas diets with enzymes were reformulated, reducing the apparent metabolizable energy (AME) by 85 kcal/kg. In the overall period (days 0-35), broilers fed diets formulated using NIRS values had higher (P < 0.001) average daily gain (+11.3%) and daily feed intake (+7.2%), and a lower (P < 0.001) feed conversion ratio (-5.3%) compared to those fed diets formulated using table values. When formulating diets for broilers with low-quality feed ingredients, performance can be improved by considering NIRS values and by the addition of NSP enzymes, even with a reduction of AME. These nutritional approaches are efficient in improving broilers' performances by themselves and even more so when they are combined. © 2017 Japanese Society of Animal Science.

Virtual Surgical Planning for Inferior Alveolar Nerve Reconstruction.

PubMed

Miloro, Michael; Markiewicz, Michael R

2017-11-01

The purpose of this study was to assess the outcomes after preoperative virtual surgical planning (VSP) for inferior alveolar nerve (IAN) reconstruction in ablative mandibular surgery. We performed a retrospective evaluation of consecutive surgical cases using standard VSP for hard tissue resection and reconstructive surgery in addition to IAN VSP performed simultaneously during surgery. Cases were assessed regarding the planning time, additional costs involved, surgeon's subjective impression of the process, accuracy of the prediction during surgery, and operative time during surgery compared with cases performed without VSP. The study sample was composed of 5 cases of mandibular resection for benign disease, with bony, soft tissue, and neural reconstruction with the use of VSP. The addition of IAN reconstruction to the VSP session added no additional expense to the planning session but resulted in an additional 22.5 minutes (±7.5 minutes) for the webinar session. From a subjective standpoint, IAN VSP provided the surgeon with a discreet plan for surgery. From an objective standpoint, IAN VSP provided the exact length and diameter of nerve graft required for surgery, facilitated the surgeon's ability to visualize the actual nerve graft procedure, and limited the additional time required for simultaneous nerve reconstruction. Despite perceived prejudice against simultaneous IAN reconstruction with complex mandibular resection and reconstruction, the use of IAN VSP may facilitate the actual surgical procedure and result in considerably improved patient outcomes without considerable additional time or cost associated with this protocol. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Descriptive analysis of neurological in-hospital consultations in a tertiary hospital.

PubMed

Aller-Alvarez, J S; Quintana, M; Santamarina, E; Álvarez-Sabín, J

2017-04-01

In-hospital consultations (IHC) are essential in clinical practice in tertiary hospitals. The aim of this study is to analyse the impact of neurological IHCs. One-year retrospective descriptive study of neurological IHCs conducted from May 2013 to April 2014 at our tertiary hospital. A total of 472 patients were included (mean age, 62.1 years; male patients, 56.8%) and 24.4% had previously been evaluated by a neurologist. Patients were hospitalised a median of 18 days and 19.7% had been referred by another hospital. The departments requesting the most in-hospital consultations were intensive care (20.1%), internal medicine (14.4%), and cardiology (9.1%). Reasons for requesting an IHC were stroke (26.9%), epilepsy (20.6%), and confusional states (7.6%). An on-call neurologist evaluated 41.9% of the patients. The purpose of the IHC was to provide a diagnosis in 56.3% and treatment in 28.2% of the cases; 69.5% of the patients required additional tests. Treatment was adjusted in 18.9% of patients and additional drugs were administered to 27.3%. While 62.1% of cases required no additional IHCs, 11% required further assessment, and 4.9% were transferred to the neurology department. Of the patient total, 16.9% died during hospitalisation (in 37.5%, the purpose of the consultation was to certify brain death); 45.6% were referred to the neurology department at discharge and 6.1% visited the emergency department due to neurological impairment within 6 months of discharge. IHCs facilitate diagnosis and management of patients with neurological diseases, which may help reduce the number of visits to the emergency department. On-call neurologists are essential in tertiary hospitals, and they are frequently asked to diagnose brain death. Copyright © 2015 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Supportability for Beyond Low Earth Orbit Missions

NASA Technical Reports Server (NTRS)

Crillo, William M.; Goodliff, Kandyce E.; Aaseng, Gordon; Stromgren, Chel; Maxwell, Andrew J.

2011-01-01

Exploration beyond Low Earth Orbit (LEO) presents many unique challenges that will require changes from current Supportability approaches. Currently, the International Space Station (ISS) is supported and maintained through a series of preplanned resupply flights, on which spare parts, including some large, heavy Orbital Replacement Units (ORUs), are delivered to the ISS. The Space Shuttle system provided for a robust capability to return failed components to Earth for detailed examination and potential repair. Additionally, as components fail and spares are not already on-orbit, there is flexibility in the transportation system to deliver those required replacement parts to ISS on a near term basis. A similar concept of operation will not be feasible for beyond LEO exploration. The mass and volume constraints of the transportation system and long envisioned mission durations could make it difficult to manifest necessary spares. The supply of on-demand spare parts for missions beyond LEO will be very limited or even non-existent. In addition, the remote nature of the mission, the design of the spacecraft, and the limitations on crew capabilities will all make it more difficult to maintain the spacecraft. Alternate concepts of operation must be explored in which required spare parts, materials, and tools are made available to make repairs; the locations of the failures are accessible; and the information needed to conduct repairs is available to the crew. In this paper, ISS heritage information is presented along with a summary of the challenges of beyond LEO missions. A number of Supportability issues are discussed in relation to human exploration beyond LEO. In addition, the impacts of various Supportability strategies will be discussed. Any measure that can be incorporated to reduce risk and improve mission success should be evaluated to understand the advantages and disadvantages of implementing those measures. Finally, an effort to model and evaluate Supportability for beyond LEO missions will be described.

A decision-making tool to determine economic feasibility and break-even prices for artisan cheese operations.

PubMed

Durham, Catherine A; Bouma, Andrea; Meunier-Goddik, Lisbeth

2015-12-01

Artisan cheese makers lack access to valid economic data to help them evaluate business opportunities and make important business decisions such as determining cheese pricing structure. The objective of this study was to utilize an economic model to evaluate the net present value (NPV), internal rate of return, and payback period for artisan cheese production at different annual production volumes. The model was also used to determine the minimum retail price necessary to ensure positive NPV for 5 different cheese types produced at 4 different production volumes. Milk type, cheese yield, and aging time all affected variable costs. However, aged cheeses required additional investment for aging space (which needs to be larger for longer aging times), as did lower yield cheeses (by requiring larger-volume equipment for pasteurization and milk handling). As the volume of milk required increased, switching from vat pasteurization to high-temperature, short-time pasteurization was necessary for low-yield cheeses before being required for high-yield cheeses, which causes an additional increase in investment costs. Because of these differences, high-moisture, fresh cow milk cheeses can be sold for about half the price of hard, aged goat milk cheeses at the largest production volume or for about two-thirds the price at the lowest production volume examined. For example, for the given model assumptions, at an annual production of 13,608kg of cheese (30,000 lb), a fresh cow milk mozzarella should be sold at a minimum retail price of $27.29/kg ($12.38/lb), whereas a goat milk Gouda needs a minimum retail price of $49.54/kg ($22.47/lb). Artisan cheese makers should carefully evaluate annual production volumes. Although larger production volumes decrease average fixed cost and improve production efficiency, production can reach volumes where it becomes necessary to sell through distributors. Because distributors might pay as little as 35% of retail price, the retail price needs to be higher to compensate. An artisan cheese company that has not achieved the recognition needed to achieve a premium price may not find distribution through distributors profitable. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Breast Imaging Second Opinions Impact Surgical Management.

PubMed

Spivey, Tara Lynn; Carlson, Kjirsten Ayn; Janssen, Imke; Witt, Thomas R; Jokich, Peter; Madrigrano, Andrea

2015-07-01

Breast surgeons often see women for second opinions for abnormalities found on breast imaging. For second opinions, these images are submitted for review and interpretation by dedicated breast imagers. This study evaluated the conformity of results among interpretation of imaging submitted from outside hospitals both from tertiary care centers, as well as community programs, in an attempt to evaluate the utility of this practice for the sake of clinical management and resource utilization. A retrospective chart review was conducted on all breast patients that submitted outside imaging films for the years 2011 to 2013 at Rush University Medical Center (RUMC). The radiologic diagnosis and each patient's proposed management plan was collected and evaluated for concordance between the outside institutions and RUMC. A total of 380 patients who presented for second opinions with an interpretation of outside exams were evaluated. In 47.4 % [95 % confidence interval (CI) 42.4-52.4] of cases there was distinct variance in radiologic impression. For 53.5 % (95 % CI 48.4-58.5) of patients, there was a change in recommended management plan, which included recommendations for either additional imaging or need for additional biopsy. In total, this changed the overall surgical management in 27.1 % (95 % CI 22.8-31.9) of cases. In six patients, the reinterpretation of outside imaging detected new malignancies not previously identified. Overall, 83.7 % (95 % CI 79.7-87.1) of patients who submitted imaging from outside institutions chose to complete the remainder of their treatment at RUMC. The practice of second opinion review changed overall definitive management at our specialty center in more than one in four cases. In addition, the review identified six previously unrecognized malignancies. Given this data, the practice of second opinions and interpretation of outside exams should continue despite the additional resources required.

46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Additional survey requirements for steel-hull vessels...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...) When the vessel is in drydock, the hull plating, etc., shall be examined. (c) The holds, 'tween decks...

46 CFR 35.03-25 - Additional requirements for hybrid work vests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

46 CFR 35.03-25 - Additional requirements for hybrid work vests.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

46 CFR 35.03-25 - Additional requirements for hybrid work vests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

46 CFR 35.03-25 - Additional requirements for hybrid work vests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

46 CFR 35.03-25 - Additional requirements for hybrid work vests.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Additional requirements for hybrid work vests. 35.03-25 Section 35.03-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Work Vests § 35.03-25 Additional requirements for hybrid work vests. (a) In addition to the other requirements in...

46 CFR 42.09-35 - Additional survey requirements for wood-hull vessels.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Additional survey requirements for wood-hull vessels. 42.09-35 Section 42.09-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES... Additional survey requirements for wood-hull vessels. (a) In addition to the requirements in § 42.09-25, the...

Do prehospital discharge pacemaker checks provide any additional clinical benefit?

PubMed

Wheelan, Kevin R; Legge, Darlene M; Sakowski, Brent C; Bruce, Susan S; Roberts, David C; Johnston, L Murphy; Moore, B Jane; Beveridge, Thomas P; Wells, Peter J; Vallabahn, Ravi; Donsky, Michael S; Franklin, Jay O

2005-08-01

We performed a retrospective analysis of 250 records of consecutive, newly implanted, pacemaker patients from a single center to determine the rate of postimplant complications and observations discovered before and during the prehospital discharge evaluation. No observations occurred in 246 of 250 patients (98.4%) (1-sided 95% confidence interval 96.4%). Of the 250 patients, 4 had observations that were discovered at the prehospital discharge check and required reprogramming to increase the sensitivity safety margin (3 atrial and 1 ventricular). We documented only 1 complication that was discovered before the predischarge evaluation through telemetry and resulted in an atrial lead revision.

[Responsibilities of ethics committees].

PubMed

von Bergmann, K

1999-01-15

Increasing numbers of clinical research projects are submitted to ethical committees (institutional review boards) for approval. New therapeutic developments have to be evaluated by these committees to protect patients/volunteers. Thus, the responsibility of ethical committees is increasing. The "Nürnberger Kodex" and the "Declaration of Helsinki" are the background for these evaluations. According to the German drug law the physician is obligated by law to submit the protocol to such a committee. In addition, local state physician authorities require such a procedure. Important considerations during the review process besides ethical aspects are the informed consent, which should be written in an understandable form, and the obligations of the insurance.

[Responsibilities of ethics committees].

PubMed

von Bergmann, K

2000-05-01

Increasing numbers of clinical research projects are submitted to ethical committees (institutional review boards) for approval. New therapeutic developments have to be evaluated by these committees to protect patients/volunteers. Thus, the responsibility of ethical committees is increasing. The "Nürnberger Kodex" and the "Declaration of Helsinki" are the background for these evaluations. According to the German drug law the physician is obligated by law to submit the protocol to such a committee. In addition, local state physician authorities require such a procedure. Important considerations during the review process besides ethical aspects are the informed consent, which should be written in an understandable form, and the obligations of the insurance.

68Ga-PSMA Expression in Pseudoangiomatous Stromal Hyperplasia of the Breast.

PubMed

Malik, Dharmender; Basher, Rajender K; Mittal, Bhagwant Rai; Jain, Tarun Kumar; Bal, Amanjit; Singh, Shrawan Kumar

2017-01-01

Ga-labeled prostate-specific membrane antigen ligand PET-CT has emerged as a promising technique to evaluate the extent of disease in patients with prostate carcinoma. We are reporting a 63-year-old man with prostatic carcinoma subjected to Ga-prostate-specific membrane antigen ligand PET-CT for initial staging. In addition to the radiotracer uptake in known primary site (prostate), focal increased radiotracer uptake was also noticed in the left breast. Subsequent biopsy of the breast lesion revealed PASH (pseudoangiomatous stromal hyperplasia), which is a benign mesenchymal proliferative lesion that may present clinically as palpable mass requiring further evaluation to rule out malignancy.

Technology needs for high-speed rotorcraft

NASA Technical Reports Server (NTRS)

Rutherford, John; Orourke, Matthew; Martin, Christopher; Lovenguth, Marc; Mitchell, Clark

1991-01-01

A study to determine the technology development required for high-speed rotorcraft development was conducted. The study begins with an initial assessment of six concepts capable of flight at, or greater than 450 knots with helicopter-like hover efficiency (disk loading less than 50 pfs). These concepts were sized and evaluated based on measures of effectiveness and operational considerations. Additionally, an initial assessment of the impact of technology advances on the vehicles attributes was made. From these initial concepts a tilt wing and rotor/wing concepts were selected for further evaluation. A more detailed examination of conversion and technology trade studies were conducted on these two vehicles, each sized for a different mission.

AEROSOL PARTICLE COLLECTOR DESIGN STUDY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, S; Richard Dimenna, R

2007-09-27

A computational evaluation of a particle collector design was performed to evaluate the behavior of aerosol particles in a fast flowing gas stream. The objective of the work was to improve the collection efficiency of the device while maintaining a minimum specified air throughput, nominal collector size, and minimal power requirements. The impact of a range of parameters was considered subject to constraints on gas flow rate, overall collector dimensions, and power limitations. Potential improvements were identified, some of which have already been implemented. Other more complex changes were identified and are described here for further consideration. In addition, fruitfulmore » areas for further study are proposed.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ploskey, Gene R.; Weiland, Mark A.; Carlson, Thomas J.

The purpose of this study was to estimate dam passage and route specific survival rates for subyearling Chinook salmon smolts to a primary survival-detection array located 81 km downstream of the dam, evaluate a BGS located in the B2 forebay, and evaluate effects of two spill treatments. The 2010 study also provided estimates of forebay residence time, tailrace egress time, spill passage efficiency (SPE), and spill + B2 Corner Collector (B2CC) efficiency, as required in the Columbia Basin Fish Accords. In addition, the study estimated forebay passage survival and survival of fish traveling from the forebay entrance array, through themore » dam and downstream through 81 km of tailwater.« less

Summary Report of Comprehensive Laboratory Testing to Establish the Effectiveness of Proposed Treatment Methods for Unremediated and Remediated Nitrate Salt Waste Streams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anast, Kurt Roy; Funk, David John; Hargis, Kenneth Marshall

The inadvertent creation of transuranic waste carrying hazardous waste codes D001 and D002 requires the treatment of the material to eliminate the hazardous characteristics and allow its eventual shipment and disposal at the Waste Isolation Pilot Plant (WIPP). This report documents the effectiveness of two treatment methods proposed to stabilize both the unremediated and remediated nitrate salt waste streams (UNS and RNS, respectively) at Los Alamos National Laboratory (LANL). The two technologies include the addition of zeolite (with and without the addition of water as a processing aid) and cementation. Surrogates were developed to evaluate both the solid and liquidmore » fractions expected from parent waste containers, and both the solid and liquid fractions were tested. Both technologies are shown to be effective at eliminating the characteristic of ignitability (D001), and the addition of zeolite was determined to be effective at eliminating corrosivity (D002), with the preferred option1 of adding zeolite currently planned for implementation at LANL’s Waste Characterization, Reduction, and Repackaging Facility (WCRRF). The course of this work verified the need to evaluate and demonstrate the effectiveness of the proposed remedy for debris material, if required. The evaluation determined that WypAlls, cheesecloth, and Celotex absorbed with saturated nitrate salt solutions exhibit the ignitability characteristic (all other expected debris is not classified as ignitable). Finally, liquid surrogates containing saturated nitrate salts did not exhibit the characteristic of ignitability in their pure form (those neutralized with Kolorsafe and mixed with sWheat did exhibit D001). Sensitivity testing and an analysis were conducted to evaluate the waste form for reactivity. Tests included subjecting surrogate material to mechanical impact, friction, electrostatic discharge and thermal insults. The testing confirmed that the waste does not exhibit the characteristic of reactivity (D003). Follow-on testing was conducted to demonstrate the effectiveness of zeolite stabilization for ignitable WypAll and cheesecloth debris and additional nitrate salt solutions (those exhibiting the oxidizer characteristic) to demonstrate the effectiveness of the remedy. Follow-on testing also included testing of surrogate materials containing Waste Lock 770, which is present in four of the RNS containers, and potential items of debris such as plywood and Celotex material. Testing to evaluate the effectiveness of the remedy was performed using the specific remediation processes that are planned for use at the WCRRF. Finally, testing was also performed to evaluate the holding capacity of zeolite using a highly acidic surrogate solution and to characterize the composition of gases generated during mixing of zeolite with surrogate solutions. All these tests demonstrated the effectiveness of adding zeolite as the planned remedy.« less

Evaluation of Different Power of Near Addition in Two Different Multifocal Intraocular Lenses

PubMed Central

Unsal, Ugur; Baser, Gonen

2016-01-01

Purpose. To compare near, intermediate, and distance vision and quality of vision, when refractive rotational multifocal intraocular lenses with 3.0 diopters or diffractive multifocal intraocular lenses with 2.5 diopters near addition are implanted. Methods. 41 eyes of 41 patients in whom rotational +3.0 diopters near addition IOLs were implanted and 30 eyes of 30 patients in whom diffractive +2.5 diopters near addition IOLs were implanted after cataract surgery were reviewed. Uncorrected and corrected distance visual acuity, intermediate visual acuity, near visual acuity, and patient satisfaction were evaluated 6 months later. Results. The corrected and uncorrected distance visual acuity were the same between both groups (p = 0.50 and p = 0.509, resp.). The uncorrected intermediate and corrected intermediate and near vision acuities were better in the +2.5 near vision added intraocular lens implanted group (p = 0.049, p = 0.005, and p = 0.001, resp.) and the uncorrected near vision acuity was better in the +3.0 near vision added intraocular lens implanted group (p = 0.001). The patient satisfactions of both groups were similar. Conclusion. The +2.5 diopters near addition could be a better choice in younger patients with more distance and intermediate visual requirements (driving, outdoor activities), whereas the + 3.0 diopters should be considered for patients with more near vision correction (reading). PMID:27340560

DWPF Recycle Evaporator Simulant Tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, M

2005-04-05

Testing was performed to determine the feasibility and processing characteristics of an evaporation process to reduce the volume of the recycle stream from the Defense Waste Processing Facility (DWPF). The concentrated recycle would be returned to DWPF while the overhead condensate would be transferred to the Effluent Treatment Plant. Various blends of evaporator feed were tested using simulants developed from characterization of actual recycle streams from DWPF and input from DWPF-Engineering. The simulated feed was evaporated in laboratory scale apparatus to target a 30X volume reduction. Condensate and concentrate samples from each run were analyzed and the process characteristics (foaming,more » scaling, etc) were visually monitored during each run. The following conclusions were made from the testing: Concentration of the ''typical'' recycle stream in DWPF by 30X was feasible. The addition of DWTT recycle streams to the typical recycle stream raises the solids content of the evaporator feed considerably and lowers the amount of concentration that can be achieved. Foaming was noted during all evaporation tests and must be addressed prior to operation of the full-scale evaporator. Tests were conducted that identified Dow Corning 2210 as an antifoam candidate that warrants further evaluation. The condensate has the potential to exceed the ETP WAC for mercury, silicon, and TOC. Controlling the amount of equipment decontamination recycle in the evaporator blend would help meet the TOC limits. The evaporator condensate will be saturated with mercury and elemental mercury will collect in the evaporator condensate collection vessel. No scaling on heating surfaces was noted during the tests, but splatter onto the walls of the evaporation vessels led to a buildup of solids. These solids were difficult to remove with 2M nitric acid. Precipitation of solids was not noted during the testing. Some of the aluminum present in the recycle streams was converted from gibbsite to aluminum oxide during the evaporation process. The following recommendations were made: Recycle from the DWTT should be metered in slowly to the ''typical'' recycle streams to avoid spikes in solids content to allow consistent processing and avoid process upsets. Additional studies should be conducted to determine acceptable volume ratios for the HEME dissolution and decontamination solutions in the evaporator feed. Dow Corning 2210 antifoam should be evaluated for use to control foaming. Additional tests are required to determine the concentration of antifoam required to prevent foaming during startup, the frequency of antifoam additions required to control foaming during steady state processing, and the ability of the antifoam to control foam over a range of potential feed compositions. This evaluation should also include evaluation of the degradation of the antifoam and impact on the silicon and TOC content of the condensate. The caustic HEME dissolution recycle stream should be neutralized to at least pH of 7 prior to blending with the acidic recycle streams. Dow Corning 2210 should be used during the evaporation testing using the radioactive recycle samples received from DWPF. Evaluation of additional antifoam candidates should be conducted as a backup for Dow Corning 2210. A camera and/or foam detection instrument should be included in the evaporator design to allow monitoring of the foaming behavior during operation. The potential for foam formation and high solids content should be considered during the design of the evaporator vessel.« less

Evaluation of Additives to Reduce Solid Propellant Flammability in Ambient Air.

DTIC Science & Technology

1975-12-01

been applied successfully to reduce the flammability of plastics and polymers. From that experimental data base, the following have been shown to be...consumption rate of the cube) are reported since they are more repeatable than the linear burning rate data . B. Free Convection Effects Several series of...Steady State Burning Rate Measurements Obtaining steady state burning rate data in air requires a technique for holding the characteristic length

Federal Reserve Could Improve the Efficiency of Bank Holding Company Inspections.

DTIC Science & Technology

1981-08-18

examiners have the essential qualifications and experience needed to perform many such tasks, and it would seem to require little additional effort...activities and where the holding company and subsidiary bank management are essentially the same. (See p. 32.) AGENCY COMMENTS The Federal Reserve has...consider- ably more complex and thus moe difficult to evaluate. Most small companies are tax shells and operate essentially as banks. The risk in small

The study of the mission instruments of GOSAT-2

NASA Astrophysics Data System (ADS)

Suto, H.; Nakajima, M.; Kuze, A.; Shiomi, K.; Shimoda, H.

2012-12-01

Greenhouse Gases Observing Satellite "GOSAT" was launched in January of 2009 and have observed the carbon dioxide and the methane almost four years. Additionally, the Level 1B algorithm has been improved based on the on board calibration and ground test using Engineering model and the accuracy of the level 1B data, that is the spectrum, has been improved. This has led to the more accurate calculation of the concentration of carbon dioxide and methane with small bias. At the same time, some issues have become clearer little by little through the on orbit operation. Especially a lot of data have been affected by the cloud, so few data have been used until now. However, the satellite has come to be recognized as an effective means of the detection of the global distribution of the greenhouse gases concentration. And in addition to the effort to resolve the issues which have become clear until now, the improvement of the observation performance have been required by a lot of users. Therefore, we researched the concrete requirements of users and set the mission requirements for GOSAT-2. Based on this mission requirement, we have studied the possibilities of these requirements. This study was implemented as premises for the usage of the Fourier Transform Spectrometer to detect the greenhouse gases as well as GOSAT. We considered the methods to increase the number of the useful data. For example, the reduction of the footprints size, increase of the number of the IFOV, the intelligent pointing and so on. It's necessary to maintain the Signal to Noise ration of the GOSAT. In addition to the method to increase the number of the useful data, we have researched the size of the aperture of the optics to maintain the signal to noise ratio corresponding to the reduction of the footprint seize. But the possibility of the corner cube used in the Fourier transform spectrometer limits the aperture size. We decided the aperture size (and corner cube size) based on the trade-off among corner cube size, footprint size and signal to noise ratio and the opinions of the scientists. In addition to the improvements of the performaces, the following requirements has been presented. To evaluate the relative matters of the anthropogenic emissions, to contribute to the MRV of REDD+ and so on. In order to meet these requirements the Fourier Transform Spectrometer on GOSAT-2 will has the additional observation channel for the carbon monoxide and Imager will has the spectrometer using the grating for Nitorgen Dioxide. Now we are investigating the possibilities of these additional functions and increase of the performances and we will decide the specifications of GOSAT-2 within one year.

Performance measurement for supply chain management and evaluation criteria determination for reverse supply chain management

NASA Astrophysics Data System (ADS)

Kongar, N. Elif

2004-12-01

Today, since customers are able to obtain similar-quality products for similar prices, the lead time has become the only preference criterion for most of the consumers. Therefore, it is crucial that the lead time, i.e., the time spent from the raw material phase till the manufactured good reaches the customer, is minimized. This issue can be investigated under the title of Supply Chain Management (SCM). An efficiently managed supply chain can lead to reduced response time for customers. To achieve this, continuous observation of supply chain efficiency, i.e., a constant performance evaluation of the current SCM is required. Widely used conventional performance measurement methods lack the ability to evaluate a SCM since the supply chain is a dynamic system that requires a more thorough and flexible performance measurement technique. Balanced Scorecard (BS) is an efficient tool for measuring the performance of dynamic systems and has a proven capability of providing the decision makers with the appropriate feedback data. In addition to SCM, a relatively new management field, namely reverse supply chain management (RSCM), also necessitates an appropriate evaluation approach. RSCM differs from SCM in many aspects, i.e., the criteria used for evaluation, the high level of uncertainty involved etc., not allowing the usage of identical evaluation techniques used for SCM. This study proposes a generic Balanced Scorecard to measure the performance of supply chain management while defining the appropriate performance measures for SCM. A scorecard prototype, ESCAPE, is presented to demonstrate the evaluation process.

Scenario-Based Assessment of User Needs for Point-of-Care Robots.

PubMed

Lee, Hyeong Suk; Kim, Jeongeun

2018-01-01

This study aimed to derive specific user requirements and barriers in a real medical environment to define the essential elements and functions of two types of point-of-care (POC) robot: a telepresence robot as a tool for teleconsultation, and a bedside robot to provide emotional care for patients. An analysis of user requirements was conducted; user needs were gathered and identified, and detailed, realistic scenarios were created. The prototype robots were demonstrated in physical environments for envisioning and evaluation. In all, three nurses and three clinicians participated as evaluators to observe the demonstrations and evaluate the robot systems. The evaluators were given a brief explanation of each scene and the robots' functionality. Four major functions of the teleconsultation robot were defined and tested in the demonstration. In addition, four major functions of the bedside robot were evaluated. Among the desired functions for a teleconsultation robot, medical information delivery and communication had high priority. For a bedside robot, patient support, patient monitoring, and healthcare provider support were the desired functions. The evaluators reported that the teleconsultation robot can increase support from and access to specialists and resources. They mentioned that the bedside robot can improve the quality of hospital life. Problems identified in the demonstration were those of space conflict, communication errors, and safety issues. Incorporating this technology into healthcare services will enhance communication and teamwork skills across distances and thereby facilitate teamwork. However, repeated tests will be needed to evaluate and ensure improved performance.

Scenario-Based Assessment of User Needs for Point-of-Care Robots

PubMed Central

Lee, Hyeong Suk

2018-01-01

Objectives This study aimed to derive specific user requirements and barriers in a real medical environment to define the essential elements and functions of two types of point-of-care (POC) robot: a telepresence robot as a tool for teleconsultation, and a bedside robot to provide emotional care for patients. Methods An analysis of user requirements was conducted; user needs were gathered and identified, and detailed, realistic scenarios were created. The prototype robots were demonstrated in physical environments for envisioning and evaluation. In all, three nurses and three clinicians participated as evaluators to observe the demonstrations and evaluate the robot systems. The evaluators were given a brief explanation of each scene and the robots' functionality. Four major functions of the teleconsultation robot were defined and tested in the demonstration. In addition, four major functions of the bedside robot were evaluated. Results Among the desired functions for a teleconsultation robot, medical information delivery and communication had high priority. For a bedside robot, patient support, patient monitoring, and healthcare provider support were the desired functions. The evaluators reported that the teleconsultation robot can increase support from and access to specialists and resources. They mentioned that the bedside robot can improve the quality of hospital life. Problems identified in the demonstration were those of space conflict, communication errors, and safety issues. Conclusions Incorporating this technology into healthcare services will enhance communication and teamwork skills across distances and thereby facilitate teamwork. However, repeated tests will be needed to evaluate and ensure improved performance. PMID:29503748

Effect of Sn4+ Additives on the Microstructure and Corrosion Resistance of Anodic Coating Formed on AZ31 Magnesium Alloy in Alkaline Solution

NASA Astrophysics Data System (ADS)

Salman, S. A.; Kuroda, K.; Saito, N.; Okido, M.

Magnesium is the lightest structural metal with high specific strength and good mechanical properties. However, poor corrosion resistance limits its widespread use in many applications. Magnesium is usually treated with Chromate conversion coatings. However, due to changing environmental regulations and pollution prevention requirements, a significant push exists to find new, alternative for poisonous Cr6+. Therefore, we aim to improve corrosion resistance of anodic coatings on AZ31 alloys using low cost non-chromate electrolyte. Anodizing was carried out in alkaline solutions with tin additives. The effect of tin additives on the coating film was characterized by SEM and XRD. The corrosion resistance was evaluated using anodic and cathodic polarizations and electrochemical impedance spectroscopy (EIS). Corrosion resistance property was improved with tin additives and the best anti-corrosion property was obtained with addition of 0.03 M Na2SnO3.3H2O to anodizing solution.

TU-C-17A-03: An Integrated Contour Evaluation Software Tool Using Supervised Pattern Recognition for Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, H; Tan, J; Kavanaugh, J

Purpose: Radiotherapy (RT) contours delineated either manually or semiautomatically require verification before clinical usage. Manual evaluation is very time consuming. A new integrated software tool using supervised pattern contour recognition was thus developed to facilitate this process. Methods: The contouring tool was developed using an object-oriented programming language C# and application programming interfaces, e.g. visualization toolkit (VTK). The C# language served as the tool design basis. The Accord.Net scientific computing libraries were utilized for the required statistical data processing and pattern recognition, while the VTK was used to build and render 3-D mesh models from critical RT structures in real-timemore » and 360° visualization. Principal component analysis (PCA) was used for system self-updating geometry variations of normal structures based on physician-approved RT contours as a training dataset. The inhouse design of supervised PCA-based contour recognition method was used for automatically evaluating contour normality/abnormality. The function for reporting the contour evaluation results was implemented by using C# and Windows Form Designer. Results: The software input was RT simulation images and RT structures from commercial clinical treatment planning systems. Several abilities were demonstrated: automatic assessment of RT contours, file loading/saving of various modality medical images and RT contours, and generation/visualization of 3-D images and anatomical models. Moreover, it supported the 360° rendering of the RT structures in a multi-slice view, which allows physicians to visually check and edit abnormally contoured structures. Conclusion: This new software integrates the supervised learning framework with image processing and graphical visualization modules for RT contour verification. This tool has great potential for facilitating treatment planning with the assistance of an automatic contour evaluation module in avoiding unnecessary manual verification for physicians/dosimetrists. In addition, its nature as a compact and stand-alone tool allows for future extensibility to include additional functions for physicians’ clinical needs.« less

Evaluation of the spatial and temporal measurement requirements of remote sensors for monitoring regional air pollution episodes

NASA Technical Reports Server (NTRS)

Burke, H. H. K.; Bowley, C. J.; Barnes, J. C.

1979-01-01

The spatial and temporal measurement requirements of satellite sensors for monitoring regional air pollution episodes were evaluated. Use was made of two sets of data from the Sulfate Regional Experiment (SURE), which provided the first ground-based aerosol measurements from a regional-scale station network. The sulfate data were analyzed for two air pollution episode cases. The results of the analysis indicate that the key considerations required for episode mapping from satellite sensors are the following: (1) detection of sulfate levels exceeding 20 micron-g/cu m; (2) capability to view a broad area (of the order of 1500 km swath) because of regional extent of pollution episodes; (3) spatial resolution sufficient to detect variations in sulfate levels of greater than 10 micron-g/cu m over distances of the order of 50 to 75 km; (4) repeat coverage at least on a daily basis; and (5) satellite observations during the mid to late morning local time, when the sulfate levels have begun to increase after the early morning minimum levels, and convective-type cloud cover has not yet increased to the amount reached later in the afternoon. Analysis of the satellite imagery shows that convective clouds can obscure haze patterns. Additional parameters based on spectral analysis include wavelength and bandwidth requirements.

Human Rating Requirements for NASA's Constellation Program

NASA Technical Reports Server (NTRS)

Berdich, Debbie

2008-01-01

NASA s Constellation Program (CxP) will conduct a series of human space expeditions of increasing scope, starting with missions supporting the International Space Station and expanding to encompass the Moon and Mars. Although human-rating is an integral part of all CxP activities throughout their life cycle, NASA Procedural Requirements document NPR 8705.2B, Human-Rating Requirements (HRR) for Space Flight Systems, defines the additional processes, procedures, and requirements necessary to produce human-rated space systems that protect the safety of crew members and passengers on these NASA missions. In order to be in compliance with 8705.2B the CxP must show appropriate implementation or progression toward the HRR, or justification for an exception. Compliance includes an explanation of how the CxP intends to meet the HRR, analyses to be performed to determine implementation; and a matrix to trace the HRR to CxP requirements. The HRR requires the CxP to establish a human system integration team (HSIT), consisting of astronauts, mission operations personnel, training personnel, ground processing personnel, human factors personnel, and human engineering experts, with clearly defined authority, responsibility, and accountability to lead the human-system integration. For example, per the HRR the HSIT is involved in the evaluation of crew workload, human-in-the-loop usability evaluations, determining associated criteria, and in assessment of how these activities influenced system design. In essence, the HSIT is invaluable in CxP s ability to meet the three fundamental tenets of human rating: the process of designing, evaluating, and assuring that the total system can safely conduct the required human missions; the incorporation of design features and capabilities that accommodate human interaction with the system to enhance overall safety and mission success; and the incorporation of design features and capabilities to enable safe recovery of the crew from hazardous situations.

Proposal and evaluation of FASDIM, a Fast And Simple De-Identification Method for unstructured free-text clinical records.

PubMed

Chazard, Emmanuel; Mouret, Capucine; Ficheur, Grégoire; Schaffar, Aurélien; Beuscart, Jean-Baptiste; Beuscart, Régis

2014-04-01

Medical free-text records enable to get rich information about the patients, but often need to be de-identified by removing the Protected Health Information (PHI), each time the identification of the patient is not mandatory. Pattern matching techniques require pre-defined dictionaries, and machine learning techniques require an extensive training set. Methods exist in French, but either bring weak results or are not freely available. The objective is to define and evaluate FASDIM, a Fast And Simple De-Identification Method for French medical free-text records. FASDIM consists in removing all the words that are not present in the authorized word list, and in removing all the numbers except those that match a list of protection patterns. The corresponding lists are incremented in the course of the iterations of the method. For the evaluation, the workload is estimated in the course of records de-identification. The efficiency of the de-identification is assessed by independent medical experts on 508 discharge letters that are randomly selected and de-identified by FASDIM. Finally, the letters are encoded after and before de-identification according to 3 terminologies (ATC, ICD10, CCAM) and the codes are compared. The construction of the list of authorized words is progressive: 12h for the first 7000 letters, 16 additional hours for 20,000 additional letters. The Recall (proportion of removed Protected Health Information, PHI) is 98.1%, the Precision (proportion of PHI within the removed token) is 79.6% and the F-measure (harmonic mean) is 87.9%. In average 30.6 terminology codes are encoded per letter, and 99.02% of those codes are preserved despite the de-identification. FASDIM gets good results in French and is freely available. It is easy to implement and does not require any predefined dictionary. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Life cycle comparison of centralized wastewater treatment and urine source separation with struvite precipitation: Focus on urine nutrient management.

PubMed

Ishii, Stephanie K L; Boyer, Treavor H

2015-08-01

Alternative approaches to wastewater management including urine source separation have the potential to simultaneously improve multiple aspects of wastewater treatment, including reduced use of potable water for waste conveyance and improved contaminant removal, especially nutrients. In order to pursue such radical changes, system-level evaluations of urine source separation in community contexts are required. The focus of this life cycle assessment (LCA) is managing nutrients from urine produced in a residential setting with urine source separation and struvite precipitation, as compared with a centralized wastewater treatment approach. The life cycle impacts evaluated in this study pertain to construction of the urine source separation system and operation of drinking water treatment, decentralized urine treatment, and centralized wastewater treatment. System boundaries include fertilizer offsets resulting from the production of urine based struvite fertilizer. As calculated by the Tool for the Reduction and Assessment of Chemical and Other Environmental Impacts (TRACI), urine source separation with MgO addition for subsequent struvite precipitation with high P recovery (Scenario B) has the smallest environmental cost relative to existing centralized wastewater treatment (Scenario A) and urine source separation with MgO and Na3PO4 addition for subsequent struvite precipitation with concurrent high P and N recovery (Scenario C). Preliminary economic evaluations show that the three urine management scenarios are relatively equal on a monetary basis (<13% difference). The impacts of each urine management scenario are most sensitive to the assumed urine composition, the selected urine storage time, and the assumed electricity required to treat influent urine and toilet water used to convey urine at the centralized wastewater treatment plant. The importance of full nutrient recovery from urine in combination with the substantial chemical inputs required for N recovery via struvite precipitation indicate the need for alternative methods of N recovery. Copyright © 2015 Elsevier Ltd. All rights reserved.

An Approach to Experimental Design for the Computer Analysis of Complex Phenomenon

NASA Technical Reports Server (NTRS)

Rutherford, Brian

2000-01-01

The ability to make credible system assessments, predictions and design decisions related to engineered systems and other complex phenomenon is key to a successful program for many large-scale investigations in government and industry. Recently, many of these large-scale analyses have turned to computational simulation to provide much of the required information. Addressing specific goals in the computer analysis of these complex phenomenon is often accomplished through the use of performance measures that are based on system response models. The response models are constructed using computer-generated responses together with physical test results where possible. They are often based on probabilistically defined inputs and generally require estimation of a set of response modeling parameters. As a consequence, the performance measures are themselves distributed quantities reflecting these variabilities and uncertainties. Uncertainty in the values of the performance measures leads to uncertainties in predicted performance and can cloud the decisions required of the analysis. A specific goal of this research has been to develop methodology that will reduce this uncertainty in an analysis environment where limited resources and system complexity together restrict the number of simulations that can be performed. An approach has been developed that is based on evaluation of the potential information provided for each "intelligently selected" candidate set of computer runs. Each candidate is evaluated by partitioning the performance measure uncertainty into two components - one component that could be explained through the additional computational simulation runs and a second that would remain uncertain. The portion explained is estimated using a probabilistic evaluation of likely results for the additional computational analyses based on what is currently known about the system. The set of runs indicating the largest potential reduction in uncertainty is then selected and the computational simulations are performed. Examples are provided to demonstrate this approach on small scale problems. These examples give encouraging results. Directions for further research are indicated.

Verification System: First System-Wide Performance Test

NASA Astrophysics Data System (ADS)

Chernobay, I.; Zerbo, L.

2006-05-01

System-wide performance tests are essential for the development, testing and evaluation of individual components of the verification system. In addition to evaluating global readiness it helps establishing the practical and financial requirements for eventual operations. The first system-wide performance test (SPT1) was conducted in three phases: - A preparatory phase in May-June 2004 - A performance testing phase in April-June 2005 - An evaluation phase in the last half of 2005. The preparatory phase was developmental in nature. The main objectives for the performance testing phase included establishment of performance baseline under current provisional mode of operation (CTBT/PC- 19/1/Annex II, CTBT/WGB-21/1), examination of established requirements and procedures for operation and maintenance. To establish a system-wide performance baseline the system configuration was fixed for April-May 2005. The third month (June 2005) was used for implementation of 21 test case scenarios to examine either particular operational procedures or the response of the system components to the failures simulated under controlled conditions. A total of 163 stations and 5 certified radionuclide laboratories of International Monitoring System (IMS) participated in the performance testing phase - about 50% of the eventual IMS network. 156 IMS facilities and 40 National Data Centres (NDCs) were connected to the International Data Centre (IDC) via Global Communication Infrastructure (GCI) communication links. In addition, 12 legacy stations in the auxiliary seismic network sent data to the IDC over the Internet. During the performance testing phase, the IDC produced all required products, analysed more than 6100 seismic events and 1700 radionuclide spectra. Performance of all system elements was documented and analysed. IDC products were compared with results of data processing at the NDCs. On the basis of statistics and information collected during the SPT1 a system-wide performance baseline under current guidelines for provisional Operation and Maintenance was established. The test provided feedback for further development of the draft IMS and IDC Operational Manuals and identified priority areas for further system development.

Expansion of Microbial Monitoring Capabilities on the International Space Station (ISS)

NASA Technical Reports Server (NTRS)

Khodadad, Christina L.; Oubre, Cherie; Castro, Victoria; Flint, Stephanie; Melendez, Orlando; Ott, C. Mark; Roman, Monsi

2017-01-01

Microbial monitoring is one of the tools that the National Aeronautics and Space Administration (NASA) uses on the International Space Station (ISS) to help maintain crew health and safety. In combination with regular housekeeping and disinfection when needed, microbial monitoring provides important information to the crew about the quality of the environment. Rotation of astronauts, equipment, and cargo on the ISS can affect the microbial load in the air, surfaces, and water. The current ISS microbial monitoring methods are focused on culture-based enumeration during flight and require a significant amount of crew time as well as long incubation periods of up to 5 days there by proliferating potential pathogens. In addition, the samples require return to Earth for complete identification of the microorganisms cultivated. Although the current approach assess the quality of the ISS environment, molecular technology offers faster turn-around of information particularly beneficial in an off-nominal situation. In 2011, subject matter experts from industry and academia recommended implementation of molecular-based technologies such as quantitative real-time polymerase chain reaction (qPCR) for evaluation to replace current, culture-based technologies. The RAZOR EX (BioFire Defense, Inc, Salt Lake City, UT) a ruggedized, compact, COTS (commercial off the shelf) qPCR instrument was tested, evaluated and selected in the 2 X 2015 JSC rapid flight hardware demonstration initiative as part of the Water Monitoring Suite. RAZOR EX was launched to ISS on SpaceX-9 in July 2016 to evaluate the precision and accuracy of the hardware by testing various concentrations of DNA in microgravity compared to ground controls. Flight testing was completed between September 2016 and March 2017. Data presented will detail the hardware performance of flight testing results compared to ground controls. Future goals include additional operational ground-based testing and assay development to determine if this technology can meet spaceflight microbial monitoring requirements.

Evaluation of Canisterized Foams and Evaluation of Radiation Hardened Foams for D&D Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nicholson, J. C.

The introduction of polyurethane foams has previously been examined elsewhere within the DOE complex with regards to decontamination and decommissioning (D&D) activities, though its use has been prohibited as a result of excessive heat generation and flammability concerns per the safety basis. Should these foams be found compatible with respect to the facility safety basis requirements, D&D work involving large void containing structures such as gloveboxes could be eased through the fixation of residual contamination after decontamination efforts have concluded. To this end, SRNL embarked on a characterization of commercial epoxy foams to identify the characteristics that would be mostmore » important to safety basis requirements. Through SRNL’s efforts, the performance of commercial two-part epoxy foams was evaluated for their foaming characteristics, temperature profiles, loading capability with high-Z (high density) additives, and applicability for shielding gamma emission from isotopes including; Am-241, Cs-137, and Co-60. It was found that these foams are capable of encapsulation of a desired volume, though the ideal and experimental expansion coefficients were found to differ. While heat is generated during the reaction, no samples generated heat above 70 °C. Of the down–selected materials, heating was on the order of 40 °C for the flexible foam and 60 °C for the rigid foam. Both were found to return to room temperature after 20 minutes regardless of the volume of foam cast. It was also found that the direct introduction of high-Z additives were capable of attenuating 98% of Am-241 gamma signal, 16% of Cs-137 signal, and 9.5% of Co-60 signal at 1:1 loading capacities of total liquid constituent weight to additive weight. These efforts are currently being reviewed for the ASTM January 2017 subcommittee discussions to address the lack of test methods and standards regarding these materials with respect to D&D environments.« less

Using historical and projected future climate model simulations as drivers of agricultural and biological models (Invited)

NASA Astrophysics Data System (ADS)

Stefanova, L. B.

2013-12-01

Climate model evaluation is frequently performed as a first step in analyzing climate change simulations. Atmospheric scientists are accustomed to evaluating climate models through the assessment of model climatology and biases, the models' representation of large-scale modes of variability (such as ENSO, PDO, AMO, etc) and the relationship between these modes and local variability (e.g. the connection between ENSO and the wintertime precipitation in the Southeast US). While these provide valuable information about the fidelity of historical and projected climate model simulations from an atmospheric scientist's point of view, the application of climate model data to fields such as agriculture, ecology and biology may require additional analyses focused on the particular application's requirements and sensitivities. Typically, historical climate simulations are used to determine a mapping between the model and observed climate, either through a simple (additive for temperature or multiplicative for precipitation) or a more sophisticated (such as quantile matching) bias correction on a monthly or seasonal time scale. Plants, animals and humans however are not directly affected by monthly or seasonal means. To assess the impact of projected climate change on living organisms and related industries (e.g. agriculture, forestry, conservation, utilities, etc.), derivative measures such as the heating degree-days (HDD), cooling degree-days (CDD), growing degree-days (GDD), accumulated chill hours (ACH), wet season onset (WSO) and duration (WSD), among others, are frequently useful. We will present a comparison of the projected changes in such derivative measures calculated by applying: (a) the traditional temperature/precipitation bias correction described above versus (b) a bias correction based on the mapping between the historical model and observed derivative measures themselves. In addition, we will present and discuss examples of various application-based climate model evaluations, such as: (a) agricultural crop yield estimates and (b) species population viability estimates modeled using observed climate data vs. historical climate simulations.

Radiotherapy infrastructure and human resources in Switzerland : Present status and projected computations for 2020.

PubMed

Datta, Niloy Ranjan; Khan, Shaka; Marder, Dietmar; Zwahlen, Daniel; Bodis, Stephan

2016-09-01

The purpose of this study was to evaluate the present status of radiotherapy infrastructure and human resources in Switzerland and compute projections for 2020. The European Society of Therapeutic Radiation Oncology "Quantification of Radiation Therapy Infrastructure and Staffing" guidelines (ESTRO-QUARTS) and those of the International Atomic Energy Agency (IAEA) were applied to estimate the requirements for teleradiotherapy (TRT) units, radiation oncologists (RO), medical physicists (MP) and radiotherapy technologists (RTT). The databases used for computation of the present gap and additional requirements are (a) Global Cancer Incidence, Mortality and Prevalence (GLOBOCAN) for cancer incidence (b) the Directory of Radiotherapy Centres (DIRAC) of the IAEA for existing TRT units (c) human resources from the recent ESTRO "Health Economics in Radiation Oncology" (HERO) survey and (d) radiotherapy utilization (RTU) rates for each tumour site, published by the Ingham Institute for Applied Medical Research (IIAMR). In 2015, 30,999 of 45,903 cancer patients would have required radiotherapy. By 2020, this will have increased to 34,041 of 50,427 cancer patients. Switzerland presently has an adequate number of TRTs, but a deficit of 57 ROs, 14 MPs and 36 RTTs. By 2020, an additional 7 TRTs, 72 ROs, 22 MPs and 66 RTTs will be required. In addition, a realistic dynamic model for calculation of staff requirements due to anticipated changes in future radiotherapy practices has been proposed. This model could be tailor-made and individualized for any radiotherapy centre. A 9.8 % increase in radiotherapy requirements is expected for cancer patients over the next 5 years. The present study should assist the stakeholders and health planners in designing an appropriate strategy for meeting future radiotherapy needs for Switzerland.

Biocidal Properties of Anti-Icing Additives for Aircraft Fuels

PubMed Central

Neihof, R. A.; Bailey, C. A.

1978-01-01

The biocidal and biostatic activities of seven glycol monoalkyl ether compounds were evaluated as part of an effort to find an improved anti-icing additive for jet aircraft fuel. Typical fuel contaminants, Cladosporium resinae, Gliomastix sp., Candida sp., Pseudomonas aeruginosa, and a mixed culture containing sulfate-reducing bacteria were used as assay organisms. Studies were carried out over 3 to 4 months in two-phase systems containing jet fuel and aqueous media. Diethylene glycol monomethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, and 2-methoxyethanol were generally biocidal in aqueous concentrations of 10 to 17% for all organisms except Gliomastix, which required 25% or more. 2-Ethoxyethanol, 2-propoxyethanol, and 2-butoxyethanol were biocidal at progressively lower concentrations down to 1 to 2% for 2-butoxyethanol. The enhanced antimicrobial activity of these three compounds was attributed to cytoplasmic membrane damage because of the correlation between surface tension measurements and lytic activity with P. aeruginosa cells. The mechanism of action of the less active compounds appeared to be due to osmotic (dehydrating) effects. When all requirements are taken into account, diethylene glycol monomethyl ether appears to be the most promising replacement for the currently used additive, 2-methoxyethanol. PMID:646356

Nitrogen removal by recycle water nitritation as an attractive alternative for retrofit technologies in municipal wastewater treatment plants.

PubMed

Gil, K I; Choi, E

2004-01-01

The recycle water from sludge processing in municipal wastewater treatment plants causes many serious problems in the efficiency and stability of the mainstream process. Thus, the design approach for recycle water is an important part of any biological nutrient removal system design when a retrofit technology is required for upgrading an existing plant. Moreover, the application of nitrogen removal from recycle water using the nitritation process has recently increased due to economic reasons associated with an effective carbon allocation as well as the minimization of aeration costs. However, for the actual application of recycle water nitritation, it has not been fully examined whether or not additional volume would be required in an existing plant. In this paper, the addition of recycle water nitritation to an existing plant was evaluated based on a volume analysis and estimation of final effluent quality. It was expected that using the reserve volume of the aeration tank in existing plants, recycle water nitritation could be applied to a plant without any enlargement. With the addition of recycle water nitritation, it was estimated that the final effluent quality would be improved and stabilized, especially in the winter season.

Active thermal control system evolution

NASA Technical Reports Server (NTRS)

Petete, Patricia A.; Ames, Brian E.

1991-01-01

The 'restructured' baseline of the Space Station Freedom (SSF) has eliminated many of the growth options for the Active Thermal Control System (ATCS). Modular addition of baseline technology to increase heat rejection will be extremely difficult. The system design and the available real estate no longer accommodate this type of growth. As the station matures during its thirty years of operation, a demand of up to 165 kW of heat rejection can be expected. The baseline configuration will be able to provide 82.5 kW at Eight Manned Crew Capability (EMCC). The growth paths necessary to reach 165 kW have been identified. Doubling the heat rejection capability of SSF will require either the modification of existing radiator wings or the attachment of growth structure to the baseline truss for growth radiator wing placement. Radiator performance can be improved by enlarging the surface area or by boosting the operating temperature with a heat pump. The optimal solution will require both modifications. The addition of growth structure would permit the addition of a parallel ATCS using baseline technology. This growth system would simplify integration. The feasibility of incorporating these growth options to improve the heat rejection capacity of SSF is under evaluation.

Connecting clinical and actuarial prediction with rule-based methods.

PubMed

Fokkema, Marjolein; Smits, Niels; Kelderman, Henk; Penninx, Brenda W J H

2015-06-01

Meta-analyses comparing the accuracy of clinical versus actuarial prediction have shown actuarial methods to outperform clinical methods, on average. However, actuarial methods are still not widely used in clinical practice, and there has been a call for the development of actuarial prediction methods for clinical practice. We argue that rule-based methods may be more useful than the linear main effect models usually employed in prediction studies, from a data and decision analytic as well as a practical perspective. In addition, decision rules derived with rule-based methods can be represented as fast and frugal trees, which, unlike main effects models, can be used in a sequential fashion, reducing the number of cues that have to be evaluated before making a prediction. We illustrate the usability of rule-based methods by applying RuleFit, an algorithm for deriving decision rules for classification and regression problems, to a dataset on prediction of the course of depressive and anxiety disorders from Penninx et al. (2011). The RuleFit algorithm provided a model consisting of 2 simple decision rules, requiring evaluation of only 2 to 4 cues. Predictive accuracy of the 2-rule model was very similar to that of a logistic regression model incorporating 20 predictor variables, originally applied to the dataset. In addition, the 2-rule model required, on average, evaluation of only 3 cues. Therefore, the RuleFit algorithm appears to be a promising method for creating decision tools that are less time consuming and easier to apply in psychological practice, and with accuracy comparable to traditional actuarial methods. (c) 2015 APA, all rights reserved).

Measures That Identify Prescription Medication Misuse, Abuse, and Related Events in Clinical Trials: ACTTION Critique and Recommended Considerations.

PubMed

Smith, Shannon M; Jones, Judith K; Katz, Nathaniel P; Roland, Carl L; Setnik, Beatrice; Trudeau, Jeremiah J; Wright, Stephen; Burke, Laurie B; Comer, Sandra D; Dart, Richard C; Dionne, Raymond; Haddox, J David; Jaffe, Jerome H; Kopecky, Ernest A; Martell, Bridget A; Montoya, Ivan D; Stanton, Marsha; Wasan, Ajay D; Turk, Dennis C; Dworkin, Robert H

2017-11-01

Accurate assessment of inappropriate medication use events (ie, misuse, abuse, and related events) occurring in clinical trials is an important component in evaluating a medication's abuse potential. A meeting was convened to review all instruments measuring such events in clinical trials according to previously published standardized terminology and definitions. Only 2 approaches have been reported that are specifically designed to identify and classify misuse, abuse, and related events occurring in clinical trials, rather than to measure an individual's risk of using a medication inappropriately: the Self-Reported Misuse, Abuse, and Diversion (SR-MAD) instrument and the Misuse, Abuse, and Diversion Drug Event Reporting System (MADDERS). The conceptual basis, strengths, and limitations of these methods are discussed. To our knowledge, MADDERS is the only system available to comprehensively evaluate inappropriate medication use events prospectively to determine the underlying intent. MADDERS can also be applied retrospectively to completed trial data. SR-MAD can be used prospectively; additional development may be required to standardize its implementation and fully appraise the intent of inappropriate use events. Additional research is needed to further demonstrate the validity and utility of MADDERS as well as SR-MAD. Identifying a medication's abuse potential requires assessing inappropriate medication use events in clinical trials on the basis of a standardized event classification system. The strengths and limitations of the 2 published methods designed to evaluate inappropriate medication use events are reviewed, with recommended considerations for further development and current implementation. Copyright © 2017 American Pain Society. Published by Elsevier Inc. All rights reserved.

Social, Organizational, and Contextual Characteristics of Clinical Decision Support Systems for Intensive Insulin Therapy: A Literature Review and Case Study

PubMed Central

Campion, Thomas R.; Waitman, Lemuel R.; May, Addison K.; Ozdas, Asli; Lorenzi, Nancy M.; Gadd, Cynthia S.

2009-01-01

Introduction: Evaluations of computerized clinical decision support systems (CDSS) typically focus on clinical performance changes and do not include social, organizational, and contextual characteristics explaining use and effectiveness. Studies of CDSS for intensive insulin therapy (IIT) are no exception, and the literature lacks an understanding of effective computer-based IIT implementation and operation. Results: This paper presents (1) a literature review of computer-based IIT evaluations through the lens of institutional theory, a discipline from sociology and organization studies, to demonstrate the inconsistent reporting of workflow and care process execution and (2) a single-site case study to illustrate how computer-based IIT requires substantial organizational change and creates additional complexity with unintended consequences including error. Discussion: Computer-based IIT requires organizational commitment and attention to site-specific technology, workflow, and care processes to achieve intensive insulin therapy goals. The complex interaction between clinicians, blood glucose testing devices, and CDSS may contribute to workflow inefficiency and error. Evaluations rarely focus on the perspective of nurses, the primary users of computer-based IIT whose knowledge can potentially lead to process and care improvements. Conclusion: This paper addresses a gap in the literature concerning the social, organizational, and contextual characteristics of CDSS in general and for intensive insulin therapy specifically. Additionally, this paper identifies areas for future research to define optimal computer-based IIT process execution: the frequency and effect of manual data entry error of blood glucose values, the frequency and effect of nurse overrides of CDSS insulin dosing recommendations, and comprehensive ethnographic study of CDSS for IIT. PMID:19815452

Inertial Energy Storage for Spacecraft

NASA Technical Reports Server (NTRS)

Rodriguez, G. E.

1984-01-01

The feasibility of inertial energy storage in a spacecraft power system is evaluated on the basis of a conceptual integrated design that encompasses a composite rotor, magnetic suspension and a permanent magnet (PM) motor/generator for a 3-kW orbital average payload at a bus distribution voltage of 250 volts dc. The conceptual design, is referred to as a Mechanical Capacitor. The baseline power system configuration selected is a series system employing peak-power-tracking for a Low Earth-Orbiting application. Power processing, required in the motor/generator, provides potential alternative that can only be achieved in systems with electrochemical energy storage by the addition of power processing components. One such alternative configuration provides for peak-power-tracking of the solar array and still maintains a regulated bus, without the expense of additional power processing components. Precise speed control of the two counterrotating wheels is required to reduce interaction with the attitude control system (ACS) or alternatively, used to perform attitude control functions.

TRPC1 is required for survival and proliferation of cochlear spiral ganglion stem/progenitor cells.

PubMed

Chen, Hsin-Chien; Wang, Chih-Hung; Shih, Cheng-Ping; Chueh, Sheau-Huei; Liu, Shu-Fan; Chen, Hang-Kang; Lin, Yi-Chun

2015-12-01

The present studies were designed to test the hypothesis that canonical transient receptor potential channel 1 (TRPC1) is required for the proliferation of cochlear spiral ganglion stem/progenitor cells (SPCs). TRPC1 were detected and evaluated in postnatal day 1 CBA/CaJ mice pups derived-cochlear spiral ganglion SPCs by reverse transcription-polymerase chain reaction, Western blot, immunocytochemistry, and calcium imaging. The cell viability and proliferation of the spiral ganglion SPCs following si-RNA mediated knockdown of TRPC1 or addition of TRPC channel blocker SKF9635 were compared to controls. In spiral ganglion SPCs, TRPC1 was found to be the most abundantly expressed TRPC subunit and shown to contribute to store-operated calcium entry. Silencing of TRPC1 or addition of TRPC channel blockers significantly decreased the rate of cell proliferation. The results suggest that TRPC1 might serve as an essential molecule in regulating the proliferation of spiral ganglion SPCs. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Evaluating Health Information Systems Using Ontologies

PubMed Central

Anderberg, Peter; Larsson, Tobias C; Fricker, Samuel A; Berglund, Johan

2016-01-01

Background There are several frameworks that attempt to address the challenges of evaluation of health information systems by offering models, methods, and guidelines about what to evaluate, how to evaluate, and how to report the evaluation results. Model-based evaluation frameworks usually suggest universally applicable evaluation aspects but do not consider case-specific aspects. On the other hand, evaluation frameworks that are case specific, by eliciting user requirements, limit their output to the evaluation aspects suggested by the users in the early phases of system development. In addition, these case-specific approaches extract different sets of evaluation aspects from each case, making it challenging to collectively compare, unify, or aggregate the evaluation of a set of heterogeneous health information systems. Objectives The aim of this paper is to find a method capable of suggesting evaluation aspects for a set of one or more health information systems—whether similar or heterogeneous—by organizing, unifying, and aggregating the quality attributes extracted from those systems and from an external evaluation framework. Methods On the basis of the available literature in semantic networks and ontologies, a method (called Unified eValuation using Ontology; UVON) was developed that can organize, unify, and aggregate the quality attributes of several health information systems into a tree-style ontology structure. The method was extended to integrate its generated ontology with the evaluation aspects suggested by model-based evaluation frameworks. An approach was developed to extract evaluation aspects from the ontology that also considers evaluation case practicalities such as the maximum number of evaluation aspects to be measured or their required degree of specificity. The method was applied and tested in Future Internet Social and Technological Alignment Research (FI-STAR), a project of 7 cloud-based eHealth applications that were developed and deployed across European Union countries. Results The relevance of the evaluation aspects created by the UVON method for the FI-STAR project was validated by the corresponding stakeholders of each case. These evaluation aspects were extracted from a UVON-generated ontology structure that reflects both the internally declared required quality attributes in the 7 eHealth applications of the FI-STAR project and the evaluation aspects recommended by the Model for ASsessment of Telemedicine applications (MAST) evaluation framework. The extracted evaluation aspects were used to create questionnaires (for the corresponding patients and health professionals) to evaluate each individual case and the whole of the FI-STAR project. Conclusions The UVON method can provide a relevant set of evaluation aspects for a heterogeneous set of health information systems by organizing, unifying, and aggregating the quality attributes through ontological structures. Those quality attributes can be either suggested by evaluation models or elicited from the stakeholders of those systems in the form of system requirements. The method continues to be systematic, context sensitive, and relevant across a heterogeneous set of health information systems. PMID:27311735

Evaluating Health Information Systems Using Ontologies.

PubMed

Eivazzadeh, Shahryar; Anderberg, Peter; Larsson, Tobias C; Fricker, Samuel A; Berglund, Johan

2016-06-16

There are several frameworks that attempt to address the challenges of evaluation of health information systems by offering models, methods, and guidelines about what to evaluate, how to evaluate, and how to report the evaluation results. Model-based evaluation frameworks usually suggest universally applicable evaluation aspects but do not consider case-specific aspects. On the other hand, evaluation frameworks that are case specific, by eliciting user requirements, limit their output to the evaluation aspects suggested by the users in the early phases of system development. In addition, these case-specific approaches extract different sets of evaluation aspects from each case, making it challenging to collectively compare, unify, or aggregate the evaluation of a set of heterogeneous health information systems. The aim of this paper is to find a method capable of suggesting evaluation aspects for a set of one or more health information systems-whether similar or heterogeneous-by organizing, unifying, and aggregating the quality attributes extracted from those systems and from an external evaluation framework. On the basis of the available literature in semantic networks and ontologies, a method (called Unified eValuation using Ontology; UVON) was developed that can organize, unify, and aggregate the quality attributes of several health information systems into a tree-style ontology structure. The method was extended to integrate its generated ontology with the evaluation aspects suggested by model-based evaluation frameworks. An approach was developed to extract evaluation aspects from the ontology that also considers evaluation case practicalities such as the maximum number of evaluation aspects to be measured or their required degree of specificity. The method was applied and tested in Future Internet Social and Technological Alignment Research (FI-STAR), a project of 7 cloud-based eHealth applications that were developed and deployed across European Union countries. The relevance of the evaluation aspects created by the UVON method for the FI-STAR project was validated by the corresponding stakeholders of each case. These evaluation aspects were extracted from a UVON-generated ontology structure that reflects both the internally declared required quality attributes in the 7 eHealth applications of the FI-STAR project and the evaluation aspects recommended by the Model for ASsessment of Telemedicine applications (MAST) evaluation framework. The extracted evaluation aspects were used to create questionnaires (for the corresponding patients and health professionals) to evaluate each individual case and the whole of the FI-STAR project. The UVON method can provide a relevant set of evaluation aspects for a heterogeneous set of health information systems by organizing, unifying, and aggregating the quality attributes through ontological structures. Those quality attributes can be either suggested by evaluation models or elicited from the stakeholders of those systems in the form of system requirements. The method continues to be systematic, context sensitive, and relevant across a heterogeneous set of health information systems.

Hydrologic considerations for estimation of storage-capacity requirements of impounding and side-channel reservoirs for water supply in Ohio

USGS Publications Warehouse

Koltun, G.F.

2001-01-01

This report provides data and methods to aid in the hydrologic design or evaluation of impounding reservoirs and side-channel reservoirs used for water supply in Ohio. Data from 117 streamflow-gaging stations throughout Ohio were analyzed by means of nonsequential-mass-curve-analysis techniques to develop relations between storage requirements, water demand, duration, and frequency. Information also is provided on minimum runoff for selected durations and frequencies. Systematic record lengths for the streamflow-gaging stations ranged from about 10 to 75 years; however, in many cases, additional streamflow record was synthesized. For impounding reservoirs, families of curves are provided to facilitate the estimation of storage requirements as a function of demand and the ratio of the 7-day, 2-year low flow to the mean annual flow. Information is provided with which to evaluate separately the effects of evaporation on storage requirements. Comparisons of storage requirements for impounding reservoirs determined by nonsequential-mass-curve-analysis techniques with storage requirements determined by annual-mass-curve techniques that employ probability routing to account for carryover-storage requirements indicate that large differences in computed required storages can result from the two methods, particularly for conditions where demand cannot be met from within-year storage. For side-channel reservoirs, tables of demand-storage-frequency information are provided for a primary pump relation consisting of one variable-speed pump with a pumping capacity that ranges from 0.1 to 20 times demand. Tables of adjustment ratios are provided to facilitate determination of storage requirements for 19 other pump sets consisting of assorted combinations of fixed-speed pumps or variable-speed pumps with aggregate pumping capacities smaller than or equal to the primary pump relation. The effects of evaporation on side-channel reservoir storage requirements are incorporated into the storage-requirement estimates. The effects of an instream-flow requirement equal to the 80-percent-duration flow are also incorporated into the storage-requirement estimates.

Opportunities for Cost Effective Disposal of Radioactively Contaminated Solid Waste on the Oak Ridge Reservation, Oak Ridge, TN - 13045

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeMonia, Brian; Dunning, Don; Hampshire John

2013-07-01

Department of Energy (DOE) requirements for the release of non-real property, including solid waste, containing low levels of residual radioactive materials are specified in DOE Order 458.1 and associated guidance. Authorized limits have been approved under the requirements of DOE Order 5400.5, predecessor to DOE Order 458.1, to permit disposal of solid waste containing low levels of residual radioactive materials at solid waste landfills located within the DOE Oak Ridge Reservation (ORR). Specifically, volumetric concentration limits for disposal of solid waste at Industrial Landfill V and at Construction/Demolition Landfill VII were established in 2003 and 2007, respectively, based on themore » requirements in effect at that time, which included: an evaluation to ensure that radiation doses to the public would not exceed 25 mrem/year and would be as low as reasonably achievable (ALARA), with a goal of a few mrem/year or less (in fact, these authorized limits actually were derived to meet a dose constraint of 1 mrem/year); an evaluation of compliance with groundwater protection requirements; and reasonable assurance that the proposed disposal is not likely to result in a future requirement for remediation of the landfill. Prior to approval as DOE authorized limits, these volumetric concentration limits were coordinated with the Tennessee Department of Environment and Conservation (TDEC) and documented in a Memorandum of Understanding (MOU) between the TDEC Division of Radiological Health and the TDEC Division of Solid Waste Management. These limits apply to the disposal of soil and debris waste generated from construction, maintenance, environmental restoration, and decontamination and decommissioning (D and D) activities on the DOE Oak Ridge Reservation. The approved site-specific authorized limits were incorporated in the URS/CH2M Oak Ridge LLC (UCOR) waste profile system that authorizes disposal of special wastes at either of the RCRA Subtitle D landfills. However, a recent DOE assessment found that implementation of the site-specific authorized limits for volumetrically contaminated waste was potentially limited due in part to confusion regarding the applicability of volumetric concentration limits and/or surface activity limits to specific wastes. This paper describes recent efforts to update the authorized limits for Industrial Landfill V and Construction/Demolition Landfill VII and to improve the procedures for implementation of these criteria. The approved authorized limits have been evaluated and confirmed to meet the current requirements of DOE Order 458.1, which superseded DOE Order 5400.5 in February 2011. In addition, volumetric concentration limits have been developed for additional radionuclides, and site-specific authorized limits for wastes with surface contamination have been developed. Implementing procedures have been revised to clarify the applicability of volumetric concentration limits and surface activity limits, and to allow the use of non-destructive waste characterization methods. These changes have been designed to promote improved utilization of available disposal capacity of the onsite disposal facilities within the DOE Oak Ridge Reservation. In addition, these changes serve to bring the waste acceptance requirements at these DOE onsite landfills into greater consistency with the requirements for commercial/ public landfills under the TDEC Bulk Survey for Release (BSFR) program, including two public RCRA Subtitle D landfills in close proximity to the DOE Oak Ridge Reservation. (authors)« less

Assessing the Analytical Performance of Systems for Self-Monitoring of Blood Glucose: Concepts of Performance Evaluation and Definition of Metrological Key Terms

PubMed Central

Schnell, Oliver; Hinzmann, Rolf; Kulzer, Bernd; Freckmann, Guido; Erbach, Michael; Lodwig, Volker; Heinemann, Lutz

2013-01-01

Reliability of blood glucose (BG) measurements is a prerequisite for successful diabetes management. Publications on the evaluation of self-monitored glucose values, however, are frequently characterized by a confusion in terminology. We provide an inventory of key terms such as accuracy, trueness, precision, traceability, calibration, and matrix effect to avoid future misunderstanding. Definitions are taken from the metrological literature and international norms and explained in a language intended for nonspecialists in metrology. The terms are presented in light of the need to apply generally accepted definitions. In addition, a description of requirements and components for a sound evaluation of BG measurement systems is presented. These factors will also enable improvement in future comparisons of study results. PMID:24351185

Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review.

PubMed

Hofer, Michal; Hoferová, Zuzana; Depeš, Daniel; Falk, Martin

2017-05-19

The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating the efficacy of combining radioprotective agents developed for administration prior to irradiation and therapeutic agents administered in a post-irradiation treatment regimen. Many of the evaluated results show additivity, or even synergism, of the combined treatments in comparison with the effects of the individual component administrations. It can be deduced from these findings that the research in which combined treatments with radioprotectors/radiomitigators are explored, tested, and evaluated is well-founded. The requirement for studies highly emphasizing the need to minimize undesirable side effects of the radioprotective/radiomitigating therapies is stressed.

Evaluation tools for undergraduate program planning in times of financial austerity.

PubMed

O'Palka, J; Harris, P R

1990-05-01

This article describes the administration and outcome of two evaluation tools developed by faculty of the dietetic program for ongoing assessment of a Plan IV dietetic education program over a 4-year period. Interns and internship directors were asked to evaluate the level of skills and knowledge base of interns compared with their internship classmates. Interns were also asked to rate the effectiveness of undergraduate course assignments and activities for internship preparation. As a result of the surveys, the home economics core course work was deleted, credits were shifted from food science to nutrient metabolism courses, and credits in clinical nutrition were increased. Projects in clinical nutrition and food systems management were modified. The surveys justified program requirements and utilization of resources, and provided an additional, effective measure of faculty competence.

A Framework for Enhancing the Value of Research for Dissemination and Implementation

PubMed Central

Glasgow, Russell E.; Carpenter, Christopher R.; Grimshaw, Jeremy M.; Rabin, Borsika A.; Fernandez, Maria E.; Brownson, Ross C.

2015-01-01

A comprehensive guide that identifies critical evaluation and reporting elements necessary to move research into practice is needed. We propose a framework that highlights the domains required to enhance the value of dissemination and implementation research for end users. We emphasize the importance of transparent reporting on the planning phase of research in addition to delivery, evaluation, and long-term outcomes. We highlight key topics for which well-established reporting and assessment tools are underused (e.g., cost of intervention, implementation strategy, adoption) and where such tools are inadequate or lacking (e.g., context, sustainability, evolution) within the context of existing reporting guidelines. Consistent evaluation of and reporting on these issues with standardized approaches would enhance the value of research for practitioners and decision-makers. PMID:25393182

Evaluation of NDI compressed air foam system (cafs) applied as a retrofit. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, S.

1994-08-01

Army Engineer Firefighting Detachments require increased firefighting capability to compensate for deficiencies in structural, brush, or wildland and large petroleum storage site fires. Additionally, Army fire departments responsible for protection and prevention on posts, camps and stations have difficulty accessing new or emerging technology do not possess state-of-the-art equipment. The results of this evaluation and subsequent projects, will be reported throughout the Army in an attempt to mitigate operational deficiencies and widen the scope of knowledge in the Army fire service. The evaluation of non-developmental retrofitted compressed air foam systems show an efficiency of suppressive capabilities of water superseded bymore » water alone. Retrofitting the equipment was not easy or inexpensive but it was very successful.« less

40 CFR 63.504 - Additional requirements for performance testing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Additional requirements for performance... Additional requirements for performance testing. (a) Performance testing shall be conducted in accordance.... Sections 63.484 through 63.501 also contain specific testing requirements. (1) Performance tests shall be...

46 CFR 133.07 - Additional equipment and requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Additional equipment and requirements. 133.07 Section 133.07 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS General § 133.07 Additional equipment and requirements. The OCMI may require an OSV to...

46 CFR 133.07 - Additional equipment and requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Additional equipment and requirements. 133.07 Section 133.07 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS General § 133.07 Additional equipment and requirements. The OCMI may require an OSV to...

36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

Code of Federal Regulations, 2012 CFR

2012-07-01

... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

Code of Federal Regulations, 2011 CFR

2011-07-01

... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

36 CFR 1236.24 - What are the additional requirements for managing unstructured electronic records?

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements for managing unstructured electronic records? 1236.24 Section 1236.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC RECORDS MANAGEMENT Additional Requirements for Electronic Records § 1236.24 What are the additional requirements for managing...

33 CFR 155.1125 - Additional response plan requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Additional response plan... Additional Response Plan Requirements for Tankers Loading Cargo at a Facility Permitted Under the Trans-Alaska Pipeline Authorization Act § 155.1125 Additional response plan requirements. (a) The owner or...

33 CFR 155.1125 - Additional response plan requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Additional response plan... Additional Response Plan Requirements for Tankers Loading Cargo at a Facility Permitted Under the Trans-Alaska Pipeline Authorization Act § 155.1125 Additional response plan requirements. (a) The owner or...

33 CFR 155.1125 - Additional response plan requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Additional response plan... Additional Response Plan Requirements for Tankers Loading Cargo at a Facility Permitted Under the Trans-Alaska Pipeline Authorization Act § 155.1125 Additional response plan requirements. (a) The owner or...

42 CFR 417.592 - Additional benefits requirement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Additional benefits requirement. 417.592 Section... HEALTH CARE PREPAYMENT PLANS Medicare Payment: Risk Basis § 417.592 Additional benefits requirement. (a... benefits. Provide its Medicare enrollees with additional benefits in accordance with paragraph (c) of this...

Role of the gastroenterologist in the management of the obese patient.

PubMed

López-Serrano, Antonio; Ortiz Polo, Inmaculada; Sanz de la Vega, Javier; Moreno-Osset, Eduardo

Obesity is a highly prevalent disease worldwide, and one in which gastroenterologists can play an important role. Some digestive diseases are more common in obese patients, and preoperative evaluation may be required in some cases. Additionally, bariatric surgery can lead to digestive complications in the short and long term that require intervention, and endoscopic treatment can be an important factor in weight loss. The aim of this review is to highlight the role of the gastroenterologist in the management of obese patients who are either scheduled for or have undergone surgical or endoscopic treatment for obesity. Copyright © 2016 Elsevier España, S.L.U., AEEH y AEG. All rights reserved.

Initial dynamic load estimates during configuration design

NASA Technical Reports Server (NTRS)

Schiff, Daniel

1987-01-01

This analysis includes the structural response to shock and vibration and evaluates the maximum deflections and material stresses and the potential for the occurrence of elastic instability, fatigue and fracture. The required computations are often performed by means of finite element analysis (FEA) computer programs in which the structure is simulated by a finite element model which may contain thousands of elements. The formulation of a finite element model can be time consuming, and substantial additional modeling effort may be necessary if the structure requires significant changes after initial analysis. Rapid methods for obtaining rough estimates of the structural response to shock and vibration are presented for the purpose of providing guidance during the initial mechanical design configuration stage.

Evaluation of high temperature superconductive thermal bridges for space-borne cryogenic infrared detectors

NASA Technical Reports Server (NTRS)

Scott, Elaine P.

1993-01-01

The focus of this research is on the reduction of the refrigeration requirements for infrared sensors operating in space through the use of high temperature superconductive (HTS) materials as electronic leads between the cooled sensors and the relatively warmer data acquisition components. Specifically, this initial study was directed towards the design of an experiment to quantify the thermal performance of these materials in the space environment. First, an intensive review of relevant literature was undertaken, and then, design requirements were formulated. From this background information, a preliminary experimental design was developed. Additional studies will involve a thermal analysis of the experiment and further modifications of the experimental design.

Tribological Performance of Some Pennzane(Registered Trademark) Based Greases for Vacuum Applications

NASA Technical Reports Server (NTRS)

Marchetti, Mario; Jones, William R., Jr.; Street, Kenneth W.; Wheeler, Donald; Dixon, Duane; Jansen, Mark J.; Kimura, Hiroshi

2002-01-01

Commercial greases for space applications usually fulfill the requirements imposed by the severe conditions of use. The main requirement is their ability to create an EHL film, boundary film, or both under speed, load and temperature conditions that the mechanisms will operate. Three greases, all based on a multiply alkylated cyclopentane (Pennzan(R)) base oil, were studied. The thickeners were an n-octadecylterephthalamate soap, a lithium soap, and a urea derivative. A Four-Ball Tribometer and a Spiral Orbit Tribometer were employed to evaluate the greases under ultrahigh vacuum. Results indicated that all three greases yielded very low wear rates and extended lifetimes. In addition, routine physical property data is reported for each grease.

The Influence of Phase Change Materials on the Properties of Self-Compacting Concrete.

PubMed

Fenollera, María; Míguez, José Luis; Goicoechea, Itziar; Lorenzo, Jaime; Ángel Álvarez, Miguel

2013-08-15

The aim of this paper is to research new thermally-efficient concrete walls, analyzing the mechanical behavior of a self-compacting concrete to manufacture an uncoated solid structural panel, with the incorporation of a micro-encapsulated phase change material as additive. Different dosages are tested and mechanical properties of the product obtained from the molding of concrete specimens are evaluated, testing mechanical compressive strength, slump flow, and density. The results reveal the optimum percentage of additive in the mixture that enables compliance with the technical specifications required by the product to be manufactured. A test is also performed for measuring the thermal conductivity for the optimal sample obtained and it evidences the reduction thereof.

Arthroscopic debridement for grade III and IV chondromalacia of the knee in patients older than 60 years.

PubMed

van den Bekerom, Michel P J; Patt, Thomas W; Rutten, Sjoerd; Raven, Eric E J; van de Vis, Harm M V; Albers, G H Rob

2007-10-01

Arthroscopic debridement has been used to treat patients with degenerative knee osteoarthritis, although there is sometimes conflicting evidence documenting its efficacy. This study evaluates the success of arthroscopic debridement in elderly patients with grade III and IV chondromalacia of the knee as measured by patient satisfaction and the need for additional surgery. From December 1998 to August 2001, a total of 102 consecutive cases of knee arthroscopy in 99 patients > 60 years were performed. Average follow-up was 34 months (range: 7-104 months). Patients were asked about their satisfaction using a visual analog scale, and the presence of meniscal lesions during arthroscopy and the treatment for these lesions were evaluated. Knees also were assessed for articular surface degeneration using Outerbridge's classification for chondromalacia. The need for and type of additional surgery was evaluated. During arthroscopy, meniscal lesions requiring a partial meniscectomy were found in 95 knees. Chondromalacia was found in 92 knees; 53 knees had grade I or II chondromalacia and 39 knees had grade III or IV chondromalacia. Additional surgery was performed in 17 knees. Mean patient satisfaction score was 73 (range: 50-100) in the 39 knees with grade III or IV chondromalacia after arthroscopic debridement was performed. These findings suggest arthroscopic debridement in elderly patients has a place in the treatment algorithm for grade III or IV chondromalacia of the knee.

Planning and setting objectives in field studies: Chapter 2

USGS Publications Warehouse

Fisher, Robert N.; Dodd, C. Kenneth

2016-01-01

This chapter enumerates the steps required in designing and planning field studies on the ecology and conservation of reptiles, as these involve a high level of uncertainty and risk. To this end, the chapter differentiates between goals (descriptions of what one intends to accomplish) and objectives (the measurable steps required to achieve the established goals). Thus, meeting a specific goal may require many objectives. It may not be possible to define some of them until certain experiments have been conducted; often evaluations of sampling protocols are needed to increase certainty in the biological results. And if sampling locations are fixed and sampling events are repeated over time, then both study-specific covariates and sampling-specific covariates should exist. Additionally, other critical design considerations for field study include obtaining permits, as well as researching ethics and biosecurity issues.

Development of an expert system prototype for determining software functional requirements for command management activities at NASA Goddard

NASA Technical Reports Server (NTRS)

Liebowitz, J.

1986-01-01

The development of an expert system prototype for software functional requirement determination for NASA Goddard's Command Management System, as part of its process of transforming general requests into specific near-earth satellite commands, is described. The present knowledge base was formulated through interactions with domain experts, and was then linked to the existing Knowledge Engineering Systems (KES) expert system application generator. Steps in the knowledge-base development include problem-oriented attribute hierarchy development, knowledge management approach determination, and knowledge base encoding. The KES Parser and Inspector, in addition to backcasting and analogical mapping, were used to validate the expert system-derived requirements for one of the major functions of a spacecraft, the solar Maximum Mission. Knowledge refinement, evaluation, and implementation procedures of the expert system were then accomplished.

Space Station Freedom extravehicular activity systems evolution study

NASA Technical Reports Server (NTRS)

Rouen, Michael

1990-01-01

Evaluation of Space Station Freedom (SSF) support of manned exploration is in progress to identify SSF extravehicular activity (EVA) system evolution requirements and capabilities. The output from these studies will provide data to support the preliminary design process to ensure that Space Station EVA system requirements for future missions (including the transportation node) are adequately considered and reflected in the baseline design. The study considers SSF support of future missions and the EVA system baseline to determine adequacy of EVA requirements and capabilities and to identify additional requirements, capabilities, and necessary technology upgrades. The EVA demands levied by formal requirements and indicated by evolutionary mission scenarios are high for the out-years of Space Station Freedom. An EVA system designed to meet the baseline requirements can easily evolve to meet evolution demands with few exceptions. Results to date indicate that upgrades or modifications to the EVA system may be necessary to meet the full range of EVA thermal environments associated with the transportation node. Work continues to quantify the EVA capability in this regard. Evolution mission scenarios with EVA and ground unshielded nuclear propulsion engines are inconsistent with anthropomorphic EVA capabilities.

Probability theory, not the very guide of life.

PubMed

Juslin, Peter; Nilsson, Håkan; Winman, Anders

2009-10-01

Probability theory has long been taken as the self-evident norm against which to evaluate inductive reasoning, and classical demonstrations of violations of this norm include the conjunction error and base-rate neglect. Many of these phenomena require multiplicative probability integration, whereas people seem more inclined to linear additive integration, in part, at least, because of well-known capacity constraints on controlled thought. In this article, the authors show with computer simulations that when based on approximate knowledge of probabilities, as is routinely the case in natural environments, linear additive integration can yield as accurate estimates, and as good average decision returns, as estimates based on probability theory. It is proposed that in natural environments people have little opportunity or incentive to induce the normative rules of probability theory and, given their cognitive constraints, linear additive integration may often offer superior bounded rationality.

Decision curve analysis: a novel method for evaluating prediction models.

PubMed

Vickers, Andrew J; Elkin, Elena B

2006-01-01

Diagnostic and prognostic models are typically evaluated with measures of accuracy that do not address clinical consequences. Decision-analytic techniques allow assessment of clinical outcomes but often require collection of additional information and may be cumbersome to apply to models that yield a continuous result. The authors sought a method for evaluating and comparing prediction models that incorporates clinical consequences,requires only the data set on which the models are tested,and can be applied to models that have either continuous or dichotomous results. The authors describe decision curve analysis, a simple, novel method of evaluating predictive models. They start by assuming that the threshold probability of a disease or event at which a patient would opt for treatment is informative of how the patient weighs the relative harms of a false-positive and a false-negative prediction. This theoretical relationship is then used to derive the net benefit of the model across different threshold probabilities. Plotting net benefit against threshold probability yields the "decision curve." The authors apply the method to models for the prediction of seminal vesicle invasion in prostate cancer patients. Decision curve analysis identified the range of threshold probabilities in which a model was of value, the magnitude of benefit, and which of several models was optimal. Decision curve analysis is a suitable method for evaluating alternative diagnostic and prognostic strategies that has advantages over other commonly used measures and techniques.

Correction of anterior mitral prolapse: the parachute technique.

PubMed

Zannis, Konstantinos; Mitchell-Heggs, Laurens; Di Nitto, Valentina; Kirsch, Matthias E W; Noghin, Milena; Ghorayeb, Gabriel; Lessana, Arrigo

2012-04-01

To evaluate a new surgical technique for the correction of anterior mitral leaflet prolapse. From October 2006 to November 2011, 44 consecutive patients (28 males, mean age 55 ± 13 years) underwent mitral valve repair because of anterior mitral leaflet prolapse. Echocardiography was performed to evaluate the distance from the tip of each papillary muscle to the annular plane. A specially designed caliper was used to manufacture a parachute-like device, by looping a 4-0 polytetrafluoroethylene suture between a Dacron strip and Teflon felt pledget, according to the preoperative echocardiographic measurements. This parachute was then used to resuspend the anterior mitral leaflet to the corresponding papillary muscle. Of the 44 patients, 35 (80%) required concomitant posterior leaflet repair. Additional procedures were required in 16 patients (36%). The preoperative logistic European System for Cardiac Operative Risk Evaluation was 4.3 ± 6.9. The clinical and echocardiographic follow-up were complete. The total follow-up was 1031 patient-months and averaged 23.4 ± 17.2 months per patient. The overall mortality rate was 4.5% (n = 2). Also, 2 patients (4.5%) with recurrent mitral regurgitation required mitral valve replacement, 1 on the first postoperative day and 1 after 13 months. In the latter patient, histologic analysis showed complete endothelialization of the Dacron strip. At follow-up, all non-reoperated survivors (n = 40) were in New York Heart Association class I, with no regurgitation in 40 patients (93%) and grade 2+ mitral regurgitation in 3 (7%). This technique offers a simple and reproducible solution for correction of anterior leaflet prolapse. Echocardiography can reliably evaluate the length of the chordae. However, the long-term results must be evaluated and compared with other surgical strategies. Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

Modified Universal Design Survey: Enhancing Operability of Launch Vehicle Ground Crew Worksites

NASA Technical Reports Server (NTRS)

Blume, Jennifer L.

2010-01-01

Operability is a driving requirement for next generation space launch vehicles. Launch site ground operations include numerous operator tasks to prepare the vehicle for launch or to perform preflight maintenance. Ensuring that components requiring operator interaction at the launch site are designed for optimal human use is a high priority for operability. To promote operability, a Design Quality Evaluation Survey based on Universal Design framework was developed to support Human Factors Engineering (HFE) evaluation for NASA s launch vehicles. Universal Design per se is not a priority for launch vehicle processing however; applying principles of Universal Design will increase the probability of an error free and efficient design which promotes operability. The Design Quality Evaluation Survey incorporates and tailors the seven Universal Design Principles and adds new measures for Safety and Efficiency. Adapting an approach proven to measure Universal Design Performance in Product, each principle is associated with multiple performance measures which are rated with the degree to which the statement is true. The Design Quality Evaluation Survey was employed for several launch vehicle ground processing worksite analyses. The tool was found to be most useful for comparative judgments as opposed to an assessment of a single design option. It provided a useful piece of additional data when assessing possible operator interfaces or worksites for operability.

Diagnostic challenges in celiac disease.

PubMed

Kowalski, Karol; Mulak, Agata; Jasińska, Maria; Paradowski, Leszek

2017-07-01

Diagnosis of celiac disease in adults is currently based on serologic tests in combination with histopathological assessment of small intestinal biopsy specimens. High titers of celiac-specific antibodies in immunocompetent patients with villous atrophy in a good quality biopsy sample allow us to state a confident diagnosis. The relief of symptoms and histological improvement after embarking on a gluten free diet further support the initial diagnosis. However, in some cases, these conditions are not fulfilled, which requires a critical evaluation of laboratory and histopathology results and a consideration of other potential causes for the observed pathologies. To avoid diagnostic uncertainty, both biopsy and laboratory testing should be performed on a diet containing gluten. Immune deficiency, cross reaction of antibodies and possibilities of seronegative or latent celiac disease should be considered while evaluating serology results. Uneven distribution and variable intensity of histopathological changes in the small intestine along with multiple disorders presenting a similar specimen image may lead to invalid biopsy results. Additional laboratory testing and careful examination of a patient's history may deliver important data for a differential diagnosis and a more specific biopsy evaluation. Persistence or recurrence of symptoms, despite the ongoing treatment, requires a revision of the initial diagnosis, an evaluation of the gluten free diet and a search for concurrent disorders or complications.

Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary.

PubMed

Boverhof, Darrell R; Ladics, Greg; Luebke, Bob; Botham, Jane; Corsini, Emanuela; Evans, Ellen; Germolec, Dori; Holsapple, Michael; Loveless, Scott E; Lu, Haitian; van der Laan, Jan Willem; White, Kimber L; Yang, Yung

2014-02-01

As experience is gained with toxicology testing and as new assays and technologies are developed, it is critical for stakeholders to discuss opportunities to advance our overall testing strategies. To facilitate these discussions, a workshop on practices for assessing immunotoxicity for environmental chemicals was held with the goal of sharing perspectives on immunotoxicity testing strategies and experiences, developmental immunotoxicity (DIT), and integrated and alternative approaches to immunotoxicity testing. Experiences across the chemical and pharmaceutical industries suggested that standard toxicity studies, combined with triggered-based testing approaches, represent an effective and efficient approach to evaluate immunotoxic potential. Additionally, discussions on study design, critical windows, and new guideline approaches and experiences identified important factors to consider before initiating DIT evaluations including assay choice and timing and the impact of existing adult data. Participants agreed that integrating endpoints into standard repeat-dose studies should be considered for fulfilling any immunotoxicity testing requirements, while also maximizing information and reducing animal use. Participants also acknowledged that in vitro evaluation of immunosuppression is complex and may require the use of multiple assays that are still being developed. These workshop discussions should contribute to developing an effective but more resource and animal efficient approach for evaluating chemical immunotoxicity. Copyright © 2013 Elsevier Inc. All rights reserved.

Low emittance chromated chemical conversion coatings for spacecraft thermal control in low earth orbit

NASA Astrophysics Data System (ADS)

LeVesque, R. J.; DeJesus, R. R.; Jones, C. A.; Babel, H. W.

1996-03-01

Low emittance coatings were required on the inner side of micro-meteoroid shielding and other structures to minimize heat transfer from the sun illuminated side to the underlying structure. A program was undertaken to evaluate conversion coatings for long term use in space. The conversion coatings evaluated were Alodine 1200 with three different bath chemistries, Iridite 14-2, and Alodine 600. Although the primary emphasis was on evaluating how processing conditions influenced the infrared emittance, corrosion resistance and electrical bonding characteristics were also evaluated. All of the conversion coatings were able to provide the target emittance value of less than 0.10, although baths with ferricyanide accelerators required shorter immersion times than typical of standard shop practices. The balance between emittance, corrosion resistance, and electrical bonding were defined. Space environmental stability tests were conducted on conversion coated 2219 and 7075 aluminum. The emittance and the electrical bonding characteristics were not affected by the space exposure even though the coating dehydrated and mud cracking is evident under a microscope. The dehydration resulted in a loss of corrosion resistance which is a consideration for hardware returned to Earth. It was concluded that conversion coatings are acceptable thermal control coatings for long life spacecraft although additional work is recommended for solar exposed surfaces.