Nonlinear Unsteady Aerodynamic Modeling Using Wind Tunnel and Computational Data

NASA Technical Reports Server (NTRS)

Murphy, Patrick C.; Klein, Vladislav; Frink, Neal T.

2016-01-01

Extensions to conventional aircraft aerodynamic models are required to adequately predict responses when nonlinear unsteady flight regimes are encountered, especially at high incidence angles and under maneuvering conditions. For a number of reasons, such as loss of control, both military and civilian aircraft may extend beyond normal and benign aerodynamic flight conditions. In addition, military applications may require controlled flight beyond the normal envelope, and civilian flight may require adequate recovery or prevention methods from these adverse conditions. These requirements have led to the development of more general aerodynamic modeling methods and provided impetus for researchers to improve both techniques and the degree of collaboration between analytical and experimental research efforts. In addition to more general mathematical model structures, dynamic test methods have been designed to provide sufficient information to allow model identification. This paper summarizes research to develop a modeling methodology appropriate for modeling aircraft aerodynamics that include nonlinear unsteady behaviors using both experimental and computational test methods. This work was done at Langley Research Center, primarily under the NASA Aviation Safety Program, to address aircraft loss of control, prevention, and recovery aerodynamics.

Requirements for data integration platforms in biomedical research networks: a reference model

PubMed Central

Knaup, Petra

2015-01-01

Biomedical research networks need to integrate research data among their members and with external partners. To support such data sharing activities, an adequate information technology infrastructure is necessary. To facilitate the establishment of such an infrastructure, we developed a reference model for the requirements. The reference model consists of five reference goals and 15 reference requirements. Using the Unified Modeling Language, the goals and requirements are set into relation to each other. In addition, all goals and requirements are described textually in tables. This reference model can be used by research networks as a basis for a resource efficient acquisition of their project specific requirements. Furthermore, a concrete instance of the reference model is described for a research network on liver cancer. The reference model is transferred into a requirements model of the specific network. Based on this concrete requirements model, a service-oriented information technology architecture is derived and also described in this paper. PMID:25699205

78 FR 63180 - Agency Information Collection Activities OMB Responses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... 1696.08; Fuels and Fuel Additives: Health-Effects Research Requirements for Manufacturers; 40 CFR part...; Recordkeeping and Reporting Requirements for Allegations of Significant Adverse Reactions to Human Health or the...

Photometric requirements for portable changeable message signs.

DOT National Transportation Integrated Search

2001-09-01

This project reviewed the performance of pchangeable message signs (PCMSs) and developed photometric standards to establish performance requirements. In addition, researchers developed photometric test methods and recommended them for use in evaluati...

NASA's Applied Sciences: Natural Disasters Program

NASA Technical Reports Server (NTRS)

Kessler, Jason L.

2010-01-01

Fully utilize current and near-term airborne and spaceborne assets and capabilities. NASA spaceborne instruments are for research but can be applied to natural disaster response as appropriate. NASA airborne instruments can be targeted specifically for disaster response. Could impact research programs. Better flow of information improves disaster response. Catalog capability, product, applicable disaster, points of contact. Ownership needs to come from the highest level of NASA - unpredictable and irregular nature of disasters requires contingency funding for disaster response. Build-in transfer of applicable natural disaster research capabilities to operational functionality at other agencies (e.g., USFS, NOAA, FEMA...) at the outset, whenever possible. For the Decadal Survey Missions, opportunities exist to identify needs and requirements early in the mission design process. Need to understand additional needs and commitments for meeting the needs of the disaster community. Opportunity to maximize disaster response and mitigation from the Decadal Survey Missions. Additional needs or capabilities may require agency contributions.

Capacity for research in minority health: the need for infrastructure plus will.

PubMed

Pearson, T A

2001-11-01

Cardiovascular mortality has continued to decline, but racial disparities in cardiovascular diseases (CVD) continue to grow. To build the capacity to address these racial disparities, two things will be required. First, a research and policy infrastructure must be in place to provide guidance on what to do and how to do it. Second, the will to implement and activate this infrastructure must be present at the community and policy-making levels. The Jackson Heart Study is an example of a research infrastructure with the economic resources, scientific expertise, and technical manpower required to monitor, organize, assess, and follow a cohort of individuals over time to study the burden, natural history, predictive factors, and level of care for CVD in an African American community. The creation of will within the community for CVD research may require additional strategies than in the majority community, such as community organization and local policy development. These additional efforts at the community level should create a fertile environment to develop research and, ultimately, test strategies for reducing national disparities in cardiovascular health.

Influence of ferrite phase in alite-calcium sulfoaluminate cements

NASA Astrophysics Data System (ADS)

Duvallet, Tristana Yvonne Francoise

Since the energy crisis in 1970's, research on low energy cements with low CO2- emissions has been increasing. Numerous solutions have been investigated, and the goal of this original research is to create a viable hybrid cement with the components of both Ordinary Portland cement (OPC) and calcium sulfoaluminate cement (CSAC), by forming a material that contains both alite and calcium sulfoaluminate clinker phases. Furthermore, this research focuses on keeping the cost of this material reasonable by reducing aluminum requirements through its substitution with iron. The aim of this work would produce a cement that can use large amounts of red mud, which is a plentiful waste material, in place of bauxite known as an expensive raw material. Modified Bogue equations were established and tested to formulate this novel cement with different amounts of ferrite, from 5% to 45% by weight. This was followed by the production of cement from reagent chemicals, and from industrial by-products as feedstocks (fly ash, red mud and slag). Hydration processes, as well as the mechanical properties, of these clinker compositions were studied, along with the addition of gypsum and the impact of a ferric iron complexing additive triisopropanolamine (TIPA). To summarize this research, the influence of the addition of 5-45% by weight of ferrite phase, was examined with the goal of introducing as much red mud as possible in the process without negatively attenuate the cement properties. Based on this PhD dissertation, the production of high-iron alite-calcium sulfoaluminateferrite cements was proven possible from the two sources of raw materials. The hydration processes and the mechanical properties seemed negatively affected by the addition of ferrite, as this phase was not hydrated entirely, even after 6 months of curing. The usage of TIPA counteracted this decline in strength by improving the ferrite hydration and increasing the optimum amount of gypsum required in each composition. The mechanical data were equivalent to OPC strengths for some compositions with 25% ferrite. This preliminary work constitutes the first research phase of this novel cement and requires additional research for its improvement. Topics for additional research are identified in this dissertation. KEYWORDS: alite, calcium sulfoaluminate, ferrite, low-energy cement, triisopropanolamine.

Conceptual and practical foundations of patient engagement in research at the patient-centered outcomes research institute.

PubMed

Frank, Lori; Forsythe, Laura; Ellis, Lauren; Schrandt, Suzanne; Sheridan, Sue; Gerson, Jason; Konopka, Kristen; Daugherty, Sarah

2015-05-01

To provide an overview of PCORI's approach to engagement in research. The Patient-Centered Outcomes Research Institute (PCORI) was established in 2010 to fund patient-centered comparative effectiveness research. Requirements for research funding from PCORI include meaningful engagement of patients and other stakeholders in the research. PCORI's approach to engagement in research is guided by a conceptual model of patient-centered outcomes research (PCOR), that provides a structure for understanding engagement in research. To understand and improve engagement in research PCORI is learning from awardees and other stakeholders. Those efforts are described along with PCORI's capacity building and guidance to awardees via the Engagement Rubric. PCORI's unique model of engaging patients and other stakeholders in merit review of funding applications is also described. Additional support for learning about engagement in research is provided through specific research funding and through PCORI's major infrastructure initiative, PCORnet. PCORI requires engagement of stakeholders in the research it funds. In addition PCORI engages stakeholders in activities including review of funding applications and establishment of CER research infrastructure through PCORnet. The comprehensive approach to engagement is being evaluated to help guide the field toward promising practices in research engagement.

An Authentic Research Experience for Undergraduates on a Budget: Using Data from Simple Experiments to Develop Mini-Research Proposals

ERIC Educational Resources Information Center

Robertson, Katherine

2016-01-01

The benefits of undergraduate research are well documented, and many colleges and universities include a senior research requirement for graduation. In addition, most science curricula attempt to include discoverystyle, laboratory components to prepare students for their research experiences and to expose them to research methods in different…

48 CFR 210.001 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEFENSE ACQUISITION PLANNING MARKET RESEARCH 210.001 Policy. (a) In addition to the requirements of FAR 10.001(a), agencies shall— (i) Conduct market research appropriate to the circumstances before— (A... 109-163); and (ii) Use the results of market research to determine— (A) Whether consolidation of...

48 CFR 210.001 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... DEFENSE ACQUISITION PLANNING MARKET RESEARCH 210.001 Policy. (a) In addition to the requirements of FAR 10.001(a), agencies shall— (i) Conduct market research appropriate to the circumstances before— (A... 109-163); and (ii) Use the results of market research to determine— (A) Whether consolidation of...

Microgravity

NASA Image and Video Library

2001-05-31

This diagram shows the general arrangement of the payloads to be carried by the multidisciplinary STS-107 Research-1 Space Shuttle mission in 2002. The Spacehab module will host experiments that require direct operation by the flight crew. Others with special requirements will be on the GAS Bridge Assembly sparning the payload bay. The Extended Duration Orbiter kit carries additional oxygen and hydrogen for the electricity-producing fuel cells. Research-1 experiments will cover space biology, life science, microgravity research, and commercial space product development, research sponsored by NASA's Office of Biological and Physical Research. An alternative view without callouts is available at 0101765.

Microgravity

NASA Image and Video Library

2001-05-31

Thisdiagram shows the general arrangement of the payloads to be carried by the multidisciplinary STS-107 Research-1 Space Shuttle mission in 2002. The Spacehab module will host experiments that require direct operation by the flight crew. Others with special requirements will be on the GAS Bridge Assembly sparning the payload bay. The Extended Duration Orbiter kit carries additional oxygen and hydrogen for the electricity-producing fuel cells. Research-1 experiments will cover space biology, life science, microgravity research, and commercial space product development, research sponsored by NASA's Office of Biological and Physical Research. An alternative view with callouts is available at 0101764.

STS-107 payload arrangement

NASA Technical Reports Server (NTRS)

2001-01-01

Thisdiagram shows the general arrangement of the payloads to be carried by the multidisciplinary STS-107 Research-1 Space Shuttle mission in 2002. The Spacehab module will host experiments that require direct operation by the flight crew. Others with special requirements will be on the GAS Bridge Assembly sparning the payload bay. The Extended Duration Orbiter kit carries additional oxygen and hydrogen for the electricity-producing fuel cells. Research-1 experiments will cover space biology, life science, microgravity research, and commercial space product development, research sponsored by NASA's Office of Biological and Physical Research. An alternative view with callouts is available at 0101764.

STS-107 payload arrangement

NASA Technical Reports Server (NTRS)

2001-01-01

This diagram shows the general arrangement of the payloads to be carried by the multidisciplinary STS-107 Research-1 Space Shuttle mission in 2002. The Spacehab module will host experiments that require direct operation by the flight crew. Others with special requirements will be on the GAS Bridge Assembly sparning the payload bay. The Extended Duration Orbiter kit carries additional oxygen and hydrogen for the electricity-producing fuel cells. Research-1 experiments will cover space biology, life science, microgravity research, and commercial space product development, research sponsored by NASA's Office of Biological and Physical Research. An alternative view without callouts is available at 0101765.

"Dancing on the edge of research" - What is needed to build and sustain research capacity within the massage therapy profession? A formative evaluation.

PubMed

Kania-Richmond, Ania; Menard, Martha B; Barberree, Beth; Mohring, Marvin

2017-04-01

Conducting research on massage therapy (MT) continues to be a significant challenge. To explore and identify the structures, processes, and resources required to enable viable, sustainable and high quality MT research activities in the Canadian context. Academically-based researchers and MT professionals involved in research. Formative evaluation and a descriptive qualitative approach were applied. Five main themes regarding the requirements of a productive and sustainable MT research infrastructure in Canada were identified: 1) core components, 2) variable components, 3) varying perspectives of stakeholder groups, 4) barriers to creating research infrastructure, and 5) negative metaphors. In addition, participants offered a number of recommendations on how to develop such an infrastructure. While barriers exist that require attention, participants' insights suggest there are various pathways through which a productive and sustainable MT research infrastructure can be achieved. Copyright © 2016 Elsevier Ltd. All rights reserved.

Enhancing Junior Faculty Research Productivity through Multiinstitution Collaboration: Participants' Impressions of the School Psychology Research Collaboration Conference

ERIC Educational Resources Information Center

Rush, S. Craig; Wheeler, Joanna

2011-01-01

In addition to teaching and service responsibilities, junior faculty members are required to be productive researchers. Despite the demand on junior faculty to produce published research, studies suggest that they often do not receive adequate assistance with their research endeavors. Mentoring is an effective form of support for junior faculty…

1997 Graduate Student Researchers Program

NASA Technical Reports Server (NTRS)

1996-01-01

In 1980, NASA initiated the Graduate Student Research Program (GSRP) to cultivate additional research ties to the academic community and to support a culturally diverse group of students pursuing advanced degrees in science and engineering. Eligibility requirements for this program are described, and program administrators are listed. Research areas are detailed for NASA Headquarters and all Research and Flight Centers.

A Handbook of Flight Simulation Fidelity Required for Human Factors Research

DOT National Transportation Integrated Search

1995-12-01

This report examines relevant literature for guidelines relative to the use of : flight simulators, ranging from full mission to part-task trainers, in addition : to requirements for flight crew experience and qualifications. Both sets of : guideline...

A framework for improving resident research participation and scholarly output.

PubMed

Manring, M M; Panzo, Julia A; Mayerson, Joel L

2014-01-01

The Accreditation Council for Graduate Medical Education requires that "faculty should encourage and support residents in scholarly activities." There are no guidelines, however, to illustrate how this should be done, and only a small number of published reports offer examples of successful efforts to spur resident research. We sought to improve our residents' participation in scholarly activities. We describe a multifaceted program to quickly build resident scholarship at an orthopaedic department. Large academic medical center in the Midwestern United States. An experienced medical editor was recruited to assist faculty and mentor residents in coordinating research projects and to direct publishing activity. Additional publishing requirements were added to the resident curriculum beyond those already required by the Accreditation Council for Graduate Medical Education. Residents were required to select a faculty research mentor to guide all research projects toward a manuscript suitable for submission to a peer-reviewed journal. Activities were monitored by the editor and the resident coordinator. Over 4 years, total department peer-reviewed publications increased from 33 to 163 annually. Despite a decrease in resident complement, the number of peer-reviewed publications with a resident author increased from 6 in 2009 to 53 in 2012. The addition of an experienced medical editor, changes in program requirements, and an increased commitment to promotion of resident research across the faculty led to a dramatic increase in resident publications. Our changes may be a model for other programs that have the financial resources and faculty commitment necessary to achieve a rapid turnaround. Copyright © 2014 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

48 CFR 7.107 - Additional requirements for acquisitions involving bundling.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the agency must conduct market research to determine whether bundling is necessary and justified (15 U.S.C. 644(e)(2)). Market research may indicate that bundling is necessary and justified if an agency...

Understanding synergy.

PubMed

Geary, Nori

2013-02-01

Analysis of the interactive effects of combinations of hormones or other manipulations with qualitatively similar individual effects is an important topic in basic and clinical endocrinology as well as other branches of basic and clinical research related to integrative physiology. Functional, as opposed to mechanistic, analyses of interactions rely on the concept of synergy, which can be defined qualitatively as a cooperative action or quantitatively as a supra-additive effect according to some metric for the addition of different dose-effect curves. Unfortunately, dose-effect curve addition is far from straightforward; rather, it requires the development of an axiomatic mathematical theory. I review the mathematical soundness, face validity, and utility of the most frequently used approaches to supra-additive synergy. These criteria highlight serious problems in the two most common synergy approaches, response additivity and Loewe additivity, which is the basis of the isobole and related response surface approaches. I conclude that there is no adequate, generally applicable, supra-additive synergy metric appropriate for endocrinology or any other field of basic and clinical integrative physiology. I recommend that these metrics be abandoned in favor of the simpler definition of synergy as a cooperative, i.e., nonantagonistic, effect. This simple definition avoids mathematical difficulties, is easily applicable, meets regulatory requirements for combination therapy development, and suffices to advance phenomenological basic research to mechanistic studies of interactions and clinical combination therapy research.

Additive manufacturing in production: challenges and opportunities

NASA Astrophysics Data System (ADS)

Ahuja, Bhrigu; Karg, Michael; Schmidt, Michael

2015-03-01

Additive manufacturing, characterized by its inherent layer by layer fabrication methodology has been coined by many as the latest revolution in the manufacturing industry. Due to its diversification of Materials, processes, system technology and applications, Additive Manufacturing has been synonymized with terminology such as Rapid prototyping, 3D printing, free-form fabrication, Additive Layer Manufacturing, etc. A huge media and public interest in the technology has led to an innovative attempt of exploring the technology for applications beyond the scope of the traditional engineering industry. Nevertheless, it is believed that a critical factor for the long-term success of Additive Manufacturing would be its ability to fulfill the requirements defined by the traditional manufacturing industry. A parallel development in market trends and product requirements has also lead to a wider scope of opportunities for Additive Manufacturing. The presented paper discusses some of the key challenges which are critical to ensure that Additive Manufacturing is truly accepted as a mainstream production technology in the industry. These challenges would highlight on various aspects of production such as product requirements, process management, data management, intellectual property, work flow management, quality assurance, resource planning, etc. In Addition, changing market trends such as product life cycle, mass customization, sustainability, environmental impact and localized production will form the foundation for the follow up discussion on the current limitations and the corresponding research opportunities. A discussion on ongoing research to address these challenges would include topics like process monitoring, design complexity, process standardization, multi-material and hybrid fabrication, new material development, etc.

U.S. Army Military Police: The Force of Choice for Defense Support to Civil Authorities

DTIC Science & Technology

2014-05-22

nearly identical to the qualifications and standards required for first responders and emergency managers. Additionally, within a military police...and first responders requires trust and a common professional language. Through the Police Officer Standards and Training program and Federal Law...away some of their own precious free time to review my work. The excellent research librarians at the Combined Arms Research Library were invaluable

10 CFR 35.70 - Surveys of ambient radiation exposure rate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the surveys required by paragraph (a) of this section in an area(s) where patients or human research... 10 Energy 1 2013-01-01 2013-01-01 false Surveys of ambient radiation exposure rate. 35.70 Section... Requirements § 35.70 Surveys of ambient radiation exposure rate. (a) In addition to the surveys required by...

10 CFR 35.70 - Surveys of ambient radiation exposure rate.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the surveys required by paragraph (a) of this section in an area(s) where patients or human research... 10 Energy 1 2014-01-01 2014-01-01 false Surveys of ambient radiation exposure rate. 35.70 Section... Requirements § 35.70 Surveys of ambient radiation exposure rate. (a) In addition to the surveys required by...

10 CFR 35.70 - Surveys of ambient radiation exposure rate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the surveys required by paragraph (a) of this section in an area(s) where patients or human research... 10 Energy 1 2010-01-01 2010-01-01 false Surveys of ambient radiation exposure rate. 35.70 Section... Requirements § 35.70 Surveys of ambient radiation exposure rate. (a) In addition to the surveys required by...

10 CFR 35.70 - Surveys of ambient radiation exposure rate.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the surveys required by paragraph (a) of this section in an area(s) where patients or human research... 10 Energy 1 2012-01-01 2012-01-01 false Surveys of ambient radiation exposure rate. 35.70 Section... Requirements § 35.70 Surveys of ambient radiation exposure rate. (a) In addition to the surveys required by...

10 CFR 35.70 - Surveys of ambient radiation exposure rate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the surveys required by paragraph (a) of this section in an area(s) where patients or human research... 10 Energy 1 2011-01-01 2011-01-01 false Surveys of ambient radiation exposure rate. 35.70 Section... Requirements § 35.70 Surveys of ambient radiation exposure rate. (a) In addition to the surveys required by...

78 FR 12937 - Additional Safeguards for Children in Clinical Investigations of Food and Drug Administration...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

... Act requires that all research involving children that is conducted, supported, or regulated by the... protections for children involved as subjects in research. FDA is taking this action both to comply with the... research involving children conducted, supported, or regulated by HHS be in compliance with HHS regulations...

75 FR 70266 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

... Nutrition Facts label format to require, the Agency undertook consumer research to evaluate alternatives (Refs. 1, 2, and 3). More recently, FDA conducted qualitative consumer research on the format of the.... 5). In addition to conducting consumer research, in response to the OWG plan FDA issued two advance...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

21 CFR 607.31 - Additional blood product listing information.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., the Director of the Center for Biologics Evaluation and Research may require submission of the..., upon request made by the Director of the Center for Biologics Evaluation and Research for good cause, a... Director of the Center for Biologics Evaluation and Research that it is necessary to carry out the purposes...

Thermal Control Working Group report

NASA Technical Reports Server (NTRS)

Haslett, Robert; Mahefkey, E. Thomas

1986-01-01

The Thermal Control Working Group limited its evaluation to issues associated with Earth orbiting and planetary spacecraft with power levels up to 50 kW. It was concluded that the space station technology is a necessary precursor but does not meet S/C 2000 needs (life, high heat flux, long term cryogenics, and survivability). Additional basic and applied research are required (fluid/materials compatibility and two phase system modeling). Scaling, the key issue, must define accelerated life test criteria. The two phase systems require 0g to 1 g correlation. Additional ground test beds are required and combined space environment tests of materials.

Career opportunities in clinical engineering.

PubMed

Morse, W A

1992-01-01

The varied career opportunities open to clinical engineers are described in this paper. Many of these opportunities are within the medical device industry in research, development, manufacturing design, regulatory activities, production, operations, sales, marketing, service, and management. Additional opportunities are available in hospitals, with the Veterans Administration, or working as an entrepreneur or a consultant. Each of these careers requires specific training and skills, and they all require a fundamental scientific knowledge of physical principles and mathematics. Research and management, however, require different educational preparation. The research emphasis should be on theoretical principles and creativity; the management emphasis should be on financial and labor problems. In all clinical engineering careers, the individual is a problem solver.

Beef cattle welfare in the USA: identification of priorities for future research.

PubMed

Tucker, Cassandra B; Coetzee, Johann F; Stookey, Joseph M; Thomson, Daniel U; Grandin, Temple; Schwartzkopf-Genswein, Karen S

2015-12-01

This review identifies priorities for beef cattle welfare research in the USA. Based on our professional expertise and synthesis of existing literature, we identify two themes in intensive aspects of beef production: areas where policy-based actions are needed and those where additional research is required. For some topics, considerable research informs best practice, yet gaps remain between scientific knowledge and implementation. For example, many of the risk factors and management strategies to prevent respiratory disease are understood, but only used by a relatively small portion of the industry. This is an animal health issue that will require leadership and discussion to gain widespread adoption of practices that benefit cattle welfare. There is evidence of success when such actions are taken, as illustrated by the recent improvements in handling at US slaughter facilities. Our highest priorities for additional empirical evidence are: the effect of technologies used to either promote growth or manage cattle in feedlots, identification of management risk factors for disease in feedlots, and management decisions about transport (rest stops, feed/water deprivation, climatic conditions, stocking density). Additional research is needed to inform science-based recommendations about environmental features such as dry lying areas (mounds), shade, water and feed, as well as trailer design.

University of Kansas Medical center Cancer Research Equipment Award Type: Construction Grant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caldwell, Jamie

A major mechanism to strengthen the overall cancer focus of KUCC and expand specific research programs is through targeted recruitment of additional cancer researchers to increase the national and international status of the Cancer Center, enhance the number of NCI/cancer-related grants, fill critical research needs, and enable new collaborative projects. Over the last five years KUCC has demonstrated the ability to recruit nationally recognized basic, translational and clinical scientists to fill key leadership positions and strengthen our research programs. These researchers require new and renovated research facilities require state-of-the-art laboratory equipment. This includes standard equipment for the renovated laboratories andmore » more specialized equipment as part of new investigator start-up packages. This funding is used to support recruitment, facilities, equipment, shared resources, administration, and patient care services. KUCC is committed to recruiting additional cancer researchers to increase the national and international status of the Cancer Center, enhance the number of NCI/cancer-related grants, fill critical research positions and build the four cancer research programs. Each purposeful hire aims to further the scientific vision, mission, and goals of the Cancer Center research programs. The funds requested will be used to supplement the recruitment packages of future cancer center recruits primarily through purchase of key equipment items.« less

Applying a Crew Accommodations Resource Model to Future Space Vehicle Research

NASA Technical Reports Server (NTRS)

Blume, Jennifer Linda

2003-01-01

The success of research and development for human space flight depends heavily on modeling. In addition, the use of such models is especially critical at the earliest phase of research and development of any manned vehicle or habitat. NASA is currently studying various innovative and futuristic propulsion technologies to enable further exploration of space by untended as well as tended vehicles. Details such as vehicle mass, volume, shape and configuration are required variables to evaluate the success of the propulsion concepts. For tended vehicles, the impact of the crew's requirements on those parameters must be included. This is especially important on long duration missions where the crew requirements become more complex. To address these issues, a crew accommodations resource model, developed as a mission planning tool for human spaceflight (Stillwell, Boutros, & Connolly), was applied to a reference mission in order to estimate the volume and mass required to sustain a crew for a variety of long duration missions. The model, which compiled information from numerous different sources and contains various attributes which can be modified to enable comparisons across different dimensions, was instrumental in deriving volume and mass required for a tended long duration space flight. With the inclusion of some additional variables, a set of volume and mass requirements were provided to the project. If due consideration to crew requirements for volume and mass had not been entertained, the assumptions behind validation of the propulsion technology could have been found to be incorrect, possibly far into development of the technology or even into the design and build of test vehicles. The availability and use of such a model contributes significantly by increasing the accuracy of human space flight research and development activities and acts as a cost saving measure by preventing inaccurate assumptions from driving design decisions.

Laboratory reptile surgery: principles and techniques.

PubMed

Alworth, Leanne C; Hernandez, Sonia M; Divers, Stephen J

2011-01-01

Reptiles used for research and instruction may require surgical procedures, including biopsy, coelomic device implantation, ovariectomy, orchidectomy, and esophogostomy tube placement, to accomplish research goals. Providing veterinary care for unanticipated clinical problems may require surgical techniques such as amputation, bone or shell fracture repair, and coeliotomy. Although many principles of surgery are common between mammals and reptiles, important differences in anatomy and physiology exist. Veterinarians who provide care for these species should be aware of these differences. Most reptiles undergoing surgery are small and require specific instrumentation and positioning. In addition, because of the wide variety of unique physiologic and anatomic characteristics among snakes, chelonians, and lizards, different techniques may be necessary for different reptiles. This overview describes many common reptile surgery techniques and their application for research purposes or to provide medical care to research subjects.

Interplanetary Transit Simulations Using the International Space Station

NASA Technical Reports Server (NTRS)

Charles, J. B.; Arya, Maneesh

2010-01-01

It has been suggested that the International Space Station (ISS) be utilized to simulate the transit portion of long-duration missions to Mars and near-Earth asteroids (NEA). The ISS offers a unique environment for such simulations, providing researchers with a high-fidelity platform to study, enhance, and validate technologies and countermeasures for these long-duration missions. From a space life sciences perspective, two major categories of human research activities have been identified that will harness the various capabilities of the ISS during the proposed simulations. The first category includes studies that require the use of the ISS, typically because of the need for prolonged weightlessness. The ISS is currently the only available platform capable of providing researchers with access to a weightless environment over an extended duration. In addition, the ISS offers high fidelity for other fundamental space environmental factors, such as isolation, distance, and accessibility. The second category includes studies that do not require use of the ISS in the strictest sense, but can exploit its use to maximize their scientific return more efficiently and productively than in ground-based simulations. In addition to conducting Mars and NEA simulations on the ISS, increasing the current increment duration on the ISS from 6 months to a longer duration will provide opportunities for enhanced and focused research relevant to long-duration Mars and NEA missions. Although it is currently believed that increasing the ISS crew increment duration to 9 or even 12 months will pose little additional risk to crewmembers, additional medical monitoring capabilities may be required beyond those currently used for the ISS operations. The use of the ISS to simulate aspects of Mars and NEA missions seems practical, and it is recommended that planning begin soon, in close consultation with all international partners.

75 FR 66741 - Procurement List, Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-29

... Supply Office, 452 Warehouse Street, Norfolk, VA. NPA: Professional Contract Services, Inc., Austin, TX... Research, Development, & Engineering Command, Natick, MA. Coverage: C-List for 100% of the requirement of the U.S. Army, as aggregated by the Department of the Army Research, Development, & Engineering...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

Health services research: building capacity to meet the needs of the health care system

PubMed Central

Barratt, Helen; Shaw, Jay; Simpson, Lisa; Bhatia, Sacha; Fulop, Naomi

2017-01-01

Health services researchers have an important role to play in helping health care systems around the world provide high quality, affordable services. However, gaps between the best evidence and current practice suggest that researchers need to work in new ways. The production of research that meets the needs and priorities of the health system requires researchers to work in partnership with decision-makers to conduct research and then mobilize the findings. To do this effectively, researchers require a new set of skills that are not conventionally taught as part of doctoral research programmes. In addition to wider contextual changes, researchers need to understand better the needs of decision-makers, for example through short placements in health system decision-making settings. Second, researchers need to learn to accommodate those needs throughout the research process, including identifying research needs; conducting research collaboratively with decision-makers and producing effective research products. PMID:28786700

Idea Generation and Exploration: Benefits and Limitations of the Policy Delphi Research Method

ERIC Educational Resources Information Center

Franklin, Kathy K.; Hart, Jan K.

2007-01-01

Researchers use the policy Delphi method to explore a complex topic with little historical context that requires expert opinion to fully understand underlying issues. The benefit of this research technique is the use of experts who have more timely information than can be gleamed from extant literature. Additionally, those experts place…

Hydrogen and Fuel Cell Technology | Transportation Research | NREL

Science.gov Websites

Outlines Safety Considerations for Hydrogen Technologies While safety requirements for industrial uses of vehicles have created the need for additional safety requirements. The new Hydrogen Technologies Safety hydrogen safety in context. For example, code officials reviewing permit applications for hydrogen projects

Big Data Goes Personal: Privacy and Social Challenges

ERIC Educational Resources Information Center

Bonomi, Luca

2015-01-01

The Big Data phenomenon is posing new challenges in our modern society. In addition to requiring information systems to effectively manage high-dimensional and complex data, the privacy and social implications associated with the data collection, data analytics, and service requirements create new important research problems. First, the high…

75 FR 80011 - Good Laboratory Practice for Nonclinical Laboratory Studies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-21

... for research or marketing permits for products regulated by FDA, including food and color additives, animal food additives, human and animal drugs, medical devices for human use, biological products, and... requested the ability to cite compliance with the applicable good manufacturing requirements (i.e, parts 210...

75 FR 34701 - Procurement List; Proposed Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... the U.S Army, as aggregated by the Department of the Army Research, Development, & Engineering Command... by the Department of the Army Research, Development, & Engineering Command, Natick, MA. NSN: MR 549...: MILITARY RESALE-DEFENSE-COMMISSARY AGENCY FORT LEE, VA. Coverage: C-List for the requirements of military...

Figures of Merit for Aeronautics Programs and Addition to NASA LARC Fire Station

NASA Technical Reports Server (NTRS)

Harper, Belinda M.

1995-01-01

This report accounts details of two research projects for the Langley Aerospace Research Summer Scholars (LARSS) program. The first project, with the Office of Mission Assurance, involved subjectively predicting the probable success of two aeronautics programs by means of a tool called a Figure of Merit. The figure of merit bases program success on the quality and reliability of the following factors: parts, complexity of research, quality programs, hazards elimination, and single point failures elimination. The second project, for the Office of Safety and Facilities Assurance, required planning, layouts, and source seeking for an addition to the fire house. Forecasted changes in facility layout necessitate this addition which will serve as housing for the fire fighters.

Information systems requirements for the Microgravity Science and Applications Program

NASA Technical Reports Server (NTRS)

Kicza, M. E.; Kreer, J. R.

1991-01-01

NASA's Microgravity Science and Applications (MSAD) Program is presented. Additionally, the types of information produced wiithin the program and the anticipated growth in information system requirements as the program transitions to Space Station Freedom utilization are discussed. Plans for payload operations support in the Freedom era are addressed, as well as current activities to define research community requirements for data and sample archives.

Information systems requirements for the microgravity science and applications program

NASA Technical Reports Server (NTRS)

Kicza, M. E.; Kreer, J. R.

1990-01-01

NASA's Microgravity Science and Applications (MSAD) Program is presented. Additionally, the types of information produced within the program and the anticipated growth in information system requirements as the program transitions to Space Station Freedom utilization are discussed. Plans for payload operations support in the Freedom era are addressed, as well as current activities to define research community requirements for data and sample archives.

NATOs Relevance to United States Enduring National Interests Time to Remove the Training Wheels but Continue to Hold the Handle Bars

DTIC Science & Technology

2016-06-10

shift in the United States’ view of its role within the alliance in the future. Additional research of published documentation on the current and...the Joint Advanced Warfighting School in partial satisfaction of the requirements of a Master of Science Degree in Joint Campaign Planning and...resources so I could conduct the detailed research required for this thesis. Lastly, a special thanks to the “Bulldogs” of Seminar 3, your thoughts

Laboratory Reptile Surgery: Principles and Techniques

PubMed Central

Alworth, Leanne C; Hernandez, Sonia M; Divers, Stephen J

2011-01-01

Reptiles used for research and instruction may require surgical procedures, including biopsy, coelomic device implantation, ovariectomy, orchidectomy, and esophogostomy tube placement, to accomplish research goals. Providing veterinary care for unanticipated clinical problems may require surgical techniques such as amputation, bone or shell fracture repair, and coeliotomy. Although many principles of surgery are common between mammals and reptiles, important differences in anatomy and physiology exist. Veterinarians who provide care for these species should be aware of these differences. Most reptiles undergoing surgery are small and require specific instrumentation and positioning. In addition, because of the wide variety of unique physiologic and anatomic characteristics among snakes, chelonians, and lizards, different techniques may be necessary for different reptiles. This overview describes many common reptile surgery techniques and their application for research purposes or to provide medical care to research subjects. PMID:21333158

Automobile Engine Development, Task Force Assessment, Preliminary Report.

ERIC Educational Resources Information Center

Caretto, L. S.; And Others

This report presents a comprehensive survey of current knowledge and ongoing research and development projects in the area of vehicular emissions and control. Information provided attempts to answer the questions: how can proposed standards be met with existing technology and what additional research would be required to obtain desired control…

Teacher-Education Student Perceptions for Stages of Concern Related to Integrating Technology

ERIC Educational Resources Information Center

Quadrini, Virginia Horak

2013-01-01

In this study, research includes support for technology integration in the classroom. The National Education Technology Plan Summary (2010) included research to support the requirement of teachers to integrate technology into instruction. Teacher-education student programs need to include additional training for integrating technology into…

Selective laser melting of Inconel super alloy-a review

NASA Astrophysics Data System (ADS)

Karia, M. C.; Popat, M. A.; Sangani, K. B.

2017-07-01

Additive manufacturing is a relatively young technology that uses the principle of layer by layer addition of material in solid, liquid or powder form to develop a component or product. The quality of additive manufactured part is one of the challenges to be addressed. Researchers are continuously working at various levels of additive manufacturing technologies. One of the significant powder bed processes for met als is Selective Laser Melting (SLM). Laser based processes are finding more attention of researchers and industrial world. The potential of this technique is yet to be fully explored. Due to very high strength and creep resistance Inconel is extensively used nickel based super alloy for manufacturing components for aerospace, automobile and nuclear industries. Due to law content of Aluminum and Titanium, it exhibits good fabricability too. Therefore the alloy is ideally suitable for selective laser melting to manufacture intricate components with high strength requirements. The selection of suitable process for manufacturing for a specific component depends on geometrical complexity, production quantity, and cost and required strength. There are numerous researchers working on various aspects like metallurgical and micro structural investigations and mechanical properties, geometrical accuracy, effects of process parameters and its optimization and mathematical modeling etc. The present paper represents a comprehensive overview of selective laser melting process for Inconel group of alloys.

Historical Research Skills Development in Light of a Training Program for Secondary Stage History Teachers

ERIC Educational Resources Information Center

Al-qout, Ghada Ahmed

2017-01-01

The study aimed to design a training program to develop the historical research skills after defining the nature of the historical research skills that the history teachers are required to master, especially the secondary stage teachers, in addition to defining the opinions of the educational supervisors on the extent to which the secondary…

75 FR 41449 - Procurement List Additions and Deletion

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-16

... the requirement of the U.S. Army, as aggregated by the Department of the Army Research, Development..., Philadelphia, PA Coverage: C-List for 100% of the requirement of the Department of Defense, as aggregated by... Acquisition Service, GSA/FSS OFC SUP CTR--Paper Products, New York, NY Coverage: A-List for the Total...

Additive Manufacturing in Production: A Study Case Applying Technical Requirements

NASA Astrophysics Data System (ADS)

Ituarte, Iñigo Flores; Coatanea, Eric; Salmi, Mika; Tuomi, Jukka; Partanen, Jouni

Additive manufacturing (AM) is expanding the manufacturing capabilities. However, quality of AM produced parts is dependent on a number of machine, geometry and process parameters. The variability of these parameters affects the manufacturing drastically and therefore standardized processes and harmonized methodologies need to be developed to characterize the technology for end use applications and enable the technology for manufacturing. This research proposes a composite methodology integrating Taguchi Design of Experiments, multi-objective optimization and statistical process control, to optimize the manufacturing process and fulfil multiple requirements imposed to an arbitrary geometry. The proposed methodology aims to characterize AM technology depending upon manufacturing process variables as well as to perform a comparative assessment of three AM technologies (Selective Laser Sintering, Laser Stereolithography and Polyjet). Results indicate that only one machine, laser-based Stereolithography, was feasible to fulfil simultaneously macro and micro level geometrical requirements but mechanical properties were not at required level. Future research will study a single AM system at the time to characterize AM machine technical capabilities and stimulate pre-normative initiatives of the technology for end use applications.

The Influence of Mathematics Vocabulary Instruction Embedded within Addition Tutoring for First-Grade Students with Mathematics Difficulty

ERIC Educational Resources Information Center

Powell, Sarah R.; Driver, Melissa K.

2015-01-01

Researchers and practitioners indicate students require explicit instruction on mathematics vocabulary terms, yet no study has examined the effects of an embedded vocabulary component within mathematics tutoring for early elementary students. First-grade students with mathematics difficulty (MD; n = 98) were randomly assigned to addition tutoring…

The ethics in qualitative health research: special considerations.

PubMed

Peter, Elizabeth

2015-09-01

A sound knowledge of the nature of qualitative research, along with an appreciation of some special ethical considerations, is needed for rigorous reviews to be conducted. The overall character of qualitative research is described with an emphasis on the tendency of qualitative researchers to explore sensitive topics using theoretically informed methods. A number of specific features of qualitative that require additional ethical attention and awareness are also examined including the following: 1) participants are frequently quite vulnerable and require protection because the data collection methods, such as in-depth interviews, can delve into personally and politically charged matters; 2) naturalistic observation can raise concerns regarding privacy and consent; 3) the potential for the identifiability of the results of this research may require extra efforts to maintain confidentiality. Ultimately, Reseach Ethics Committee members must be knowledgeable about qualitative approaches to be able to assess the potential harms and benefits in a protocol carefully. Without this knowledge gaining ethics approval can be overly difficult for researchers and the best practices for protecting human participants can be overlooked.

48 CFR 2915.605 - Content of unsolicited proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Unsolicited Proposals 2915.605 Content of unsolicited proposals. In addition to the contents required by FAR 15.605, unsolicited proposals for research...

48 CFR 873.108 - Publicizing contract actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 38 U.S.C., including medical practice groups and other approved entities associated with affiliated...), or from blood banks, organ banks, or research centers. In addition, the requirement for public...

Implementation of electronic medical records requires more than new software: Lessons on integrating and managing health technologies from Mbarara, Uganda.

PubMed

Madore, Amy; Rosenberg, Julie; Muyindike, Winnie R; Bangsberg, David R; Bwana, Mwebesa B; Martin, Jeffrey N; Kanyesigye, Michael; Weintraub, Rebecca

2015-12-01

Implementation lessons: • Technology alone does not necessarily lead to improvement in health service delivery, in contrast to the common assumption that advanced technology goes hand in hand with progress. • Implementation of electronic medical record (EMR) systems is a complex, resource-intensive process that, in addition to software, hardware, and human resource investments, requires careful planning, change management skills, adaptability, and continuous engagement of stakeholders. • Research requirements and goals must be balanced with service delivery needs when determining how much information is essential to collect and who should be interfacing with the EMR system. • EMR systems require ongoing monitoring and regular updates to ensure they are responsive to evolving clinical use cases and research questions. • High-quality data and analyses are essential for EMRs to deliver value to providers, researchers, and patients. Copyright © 2015 Elsevier Inc. All rights reserved.

Business Process Modelling is an Essential Part of a Requirements Analysis. Contribution of EFMI Primary Care Working Group.

PubMed

de Lusignan, S; Krause, P; Michalakidis, G; Vicente, M Tristan; Thompson, S; McGilchrist, M; Sullivan, F; van Royen, P; Agreus, L; Desombre, T; Taweel, A; Delaney, B

2012-01-01

To perform a requirements analysis of the barriers to conducting research linking of primary care, genetic and cancer data. We extended our initial data-centric approach to include socio-cultural and business requirements. We created reference models of core data requirements common to most studies using unified modelling language (UML), dataflow diagrams (DFD) and business process modelling notation (BPMN). We conducted a stakeholder analysis and constructed DFD and UML diagrams for use cases based on simulated research studies. We used research output as a sensitivity analysis. Differences between the reference model and use cases identified study specific data requirements. The stakeholder analysis identified: tensions, changes in specification, some indifference from data providers and enthusiastic informaticians urging inclusion of socio-cultural context. We identified requirements to collect information at three levels: micro- data items, which need to be semantically interoperable, meso- the medical record and data extraction, and macro- the health system and socio-cultural issues. BPMN clarified complex business requirements among data providers and vendors; and additional geographical requirements for patients to be represented in both linked datasets. High quality research output was the norm for most repositories. Reference models provide high-level schemata of the core data requirements. However, business requirements' modelling identifies stakeholder issues and identifies what needs to be addressed to enable participation.

Army Profession: How Effective Leadership Reinforces an Ethos of Trust

DTIC Science & Technology

2016-06-10

of organizational trust continues to elude researchers .”59 According to Häkkinen (2012) “most trust research has been done by using quantitative ...following in the first issue of the Journal of Trust Research . “We have to maintain a proper balance between quantitative and qualitative methods with...life context to understand trust in Army organizations required to answer the research questions. Additionally, the survey method is a quantitative

Additional Degree Required? Advanced Subject Knowledge and Academic Librarianship

ERIC Educational Resources Information Center

Ferguson, Jennifer

2016-01-01

Since the Association of College and Research Libraries (ACRL) first published its terminal degree statement in 1975, the topic of librarians and advanced subject degrees has been controversial, and research on the topic has remained limited. Based on data gathered from two major online job sites as well as library and information science programs…

Perceptions of Business Students' Feature Requirements in Educational Web Sites

ERIC Educational Resources Information Center

Hazari, Sunil; Johnson, Barbara

2007-01-01

There is paucity of original research that explains phenomena related to content organization and site design of educational Web sites. Educational Web sites are often used to provide Web-based instruction, which itself is a relatively recent phenomenon for business schools, and additional research is needed in this area. Educational Web sites are…

NASA communications technology research and development

NASA Technical Reports Server (NTRS)

Durham, A. F.; Stankiewicz, N.

1979-01-01

The development of a 1978 NASA study to identify technology requirements is surveyed, and its principal conclusions, recommendations, and priorities are summarized. In addition, antenna, traveling wave tube, and solid state amplifier developments representing selected items from the current communications technology development programs at the NASA Lewis Research and Goddard Space Flight Centers are described.

Is shade for horses a comfort resource or a minimum requirement?

PubMed

Holcomb, K E

2017-09-01

Shade or shelter as protection from extremes of weather is required for horses at agricultural research and teaching facilities and is recommended or required by many states, professional organizations, and industry groups. The focus of this paper is the recent research on the responses of horses to hot, sunny weather, which has begun to provide scientific evidence that characterizes how and when shade is used and any benefits shade confers on horses. These behavioral and physiological findings support provision of shade as a resource for thermal comfort and the expression of normal behavior that should be included as a standard of best care practices for healthy adult horses living in the environmental conditions reviewed, rather than an absolute minimum care requirement. Additional research is required for horses living under other environmental conditions, for very young or old horses, horses in very poor body condition, or those with compromised health to determine if their responses to hot, sunny weather differ from those presented here.

78 FR 56693 - Agency Information Collection Activities OMB Responses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-13

... filed comment on 08/ 13/2013. Withdrawn and Continue EPA ICR Number 1696.07; Fuels and Fuel Additives: Health-Effects Research Requirements for Manufacturers; Withdrawn from OMB and Continue existing...

The Novel Object and Unusual Name (NOUN) Database: A collection of novel images for use in experimental research.

PubMed

Horst, Jessica S; Hout, Michael C

2016-12-01

Many experimental research designs require images of novel objects. Here we introduce the Novel Object and Unusual Name (NOUN) Database. This database contains 64 primary novel object images and additional novel exemplars for ten basic- and nine global-level object categories. The objects' novelty was confirmed by both self-report and a lack of consensus on questions that required participants to name and identify the objects. We also found that object novelty correlated with qualifying naming responses pertaining to the objects' colors. The results from a similarity sorting task (and a subsequent multidimensional scaling analysis on the similarity ratings) demonstrated that the objects are complex and distinct entities that vary along several featural dimensions beyond simply shape and color. A final experiment confirmed that additional item exemplars comprised both sub- and superordinate categories. These images may be useful in a variety of settings, particularly for developmental psychology and other research in the language, categorization, perception, visual memory, and related domains.

Impact of Carbohydrate Restriction on Healthy Adolescent Development.

PubMed

Richmond, Hannah M; Duriancik, David M

2017-09-01

Carbohydrate-restricted diets are known for their impact on weight loss; however, research is still required to determine if low-carbohydrate diets are safe for adolescents. Carbohydrates directly stimulate an insulin response, and studies have recently shown that insulin and binding to respective insulin receptors (IRs) are critical in Kisspeptin (Kiss1) neuronal development. These neurons directly stimulate gonadotropin-releasing hormone, which activates the pituitary-gonadal axis during puberty. This information suggests that carbohydrate restriction may delay pubertal development in adolescents due to the impact on insulin and Kiss1 transcription. Studies have observed disturbed insulin metabolism in Type I Diabetics leading to delayed puberty, along with overfeeding stimulating early pubertal onset. Additionally, recent clinical trials bred female mice with IR deletions on Kiss1 neurons and observed delayed vaginal opening and estrus. Current animal research suggests low carbohydrate intake may delay pubertal onset, however additional research is required to determine outcome in human subjects. Copyright© of YS Medical Media ltd.

Maintenance energy requirements of odor detection, explosive detection and human detection working dogs.

PubMed

Mullis, Rebecca A; Witzel, Angela L; Price, Joshua

2015-01-01

Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing. This study is the first to evaluate the energy requirements of working dogs trained in odor, explosive and human detection. This retrospective study evaluated twenty adult dogs who maintained consistent body weights over a six month period. During this time, the average energy consumption was [Formula: see text] or two times the calculated resting energy requirement ([Formula: see text]). No statistical differences were found between breeds, age or sex, but a statistically significant association (p = 0.0033, R-square = 0.0854) was seen between the number of searches a dog performs and their energy requirement. Based on this study's population, it appears that working dogs have maintenance energy requirements similar to the 1974 National Research Council's (NRC) maintenance energy requirement of [Formula: see text] (National Research Council (NRC), 1974) and the [Formula: see text] reported for young laboratory beagles (Rainbird & Kienzle, 1990). Additional research is needed to determine if these data can be applied to all odor, explosive and human detection dogs and to determine if other types of working dogs (tracking, search and rescue etc.) have similar energy requirements.

Report endorses data sharing

NASA Astrophysics Data System (ADS)

The potential benefits of sharing data so outweigh its costs that investigators should be required to include plans for sharing data as part of their grant proposals, according to recommendations issued recently by the Committee on National Statistics (CNSTAT) of the National Research Council (NRC).In their report Sharing Research Data, CNSTAT also recommended that “Journals should give more emphasis to reports of secondary analyses and to replications,” provided that the original collections of data receive full credit. In addition, “Journal editors should require authors to provide access to data during the peer review process.”

Communication is the key to success in pragmatic clinical trials in Practice-based Research Networks (PBRNs).

PubMed

Bertram, Susan; Graham, Deborah; Kurland, Marge; Pace, Wilson; Madison, Suzanne; Yawn, Barbara P

2013-01-01

Effective communication is the foundation of feasibility and fidelity in practice-based pragmatic research studies. Doing a study with practices spread over several states requires long-distance communication strategies, including E-mails, faxes, telephone calls, conference calls, and texting. Compared with face-to-face communication, distance communication strategies are less familiar to most study coordinators and research teams. Developing and ensuring comfort with distance communications requires additional time and use of different talents and expertise than those required for face-to-face communication. It is necessary to make sure that messages are appropriate for the medium, clearly crafted, and presented in a manner that facilitates practices receiving and understanding the information. This discussion is based on extensive experience of 2 groups who have worked collaboratively on several large, federally funded, pragmatic trials in a practice-based research network. The goal of this article is to summarize lessons learned to facilitate the work of other research teams.

Protecting and Respecting the Vulnerable: Existing Regulations or Further Protections?

PubMed Central

Solomon, Stephanie R.

2013-01-01

Scholars and policymakers continue to struggle over the meaning of the word “vulnerable” in the context of research ethics. One major reason for the stymied discussions regarding vulnerable populations is that there is no clear distinction between accounts of research vulnerabilities that exist for certain populations and discussions of research vulnerabilities that require special regulations in the context of research ethics policies. I suggest an analytic process by which to ascertain whether particular vulnerable populations should be contenders for additional regulatory protections. I apply this process to two vulnerable populations: the cognitively vulnerable and the economically vulnerable. I conclude that a subset of the cognitively vulnerable require extra protections while the economically vulnerable should be protected by implementing existing regulations more appropriately and rigorously. Unless or until the informed consent process is more adequately implemented and the distributive justice requirement of the Belmont Report is emphasized and operationalized, the economically disadvantaged will remain particularly vulnerable to the harm of exploitation in research. PMID:23329228

Protecting and respecting the vulnerable: existing regulations or further protections?

PubMed

Solomon, Stephanie R

2013-02-01

Scholars and policymakers continue to struggle over the meaning of the word "vulnerable" in the context of research ethics. One major reason for the stymied discussions regarding vulnerable populations is that there is no clear distinction between accounts of research vulnerabilities that exist for certain populations and discussions of research vulnerabilities that require special regulations in the context of research ethics policies. I suggest an analytic process by which to ascertain whether particular vulnerable populations should be contenders for additional regulatory protections. I apply this process to two vulnerable populations: the cognitively vulnerable and the economically vulnerable. I conclude that a subset of the cognitively vulnerable require extra protections while the economically vulnerable should be protected by implementing existing regulations more appropriately and rigorously. Unless or until the informed consent process is more adequately implemented and the distributive justice requirement of the Belmont Report is emphasized and operationalized, the economically disadvantaged will remain particularly vulnerable to the harm of exploitation in research.

UCSC genome browser: deep support for molecular biomedical research.

PubMed

Mangan, Mary E; Williams, Jennifer M; Lathe, Scott M; Karolchik, Donna; Lathe, Warren C

2008-01-01

The volume and complexity of genomic sequence data, and the additional experimental data required for annotation of the genomic context, pose a major challenge for display and access for biomedical researchers. Genome browsers organize this data and make it available in various ways to extract useful information to advance research projects. The UCSC Genome Browser is one of these resources. The official sequence data for a given species forms the framework to display many other types of data such as expression, variation, cross-species comparisons, and more. Visual representations of the data are available for exploration. Data can be queried with sequences. Complex database queries are also easily achieved with the Table Browser interface. Associated tools permit additional query types or access to additional data sources such as images of in situ localizations. Support for solving researcher's issues is provided with active discussion mailing lists and by providing updated training materials. The UCSC Genome Browser provides a source of deep support for a wide range of biomedical molecular research (http://genome.ucsc.edu).

7 CFR 1200.51 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... and effect. In addition, unless the context otherwise requires: (a) The term Act means the Commodity... Promotion Act of 1990 [7 U.S.C. 6401-6417]; the Hass Avocado Promotion, Research, and Information Act of...

The Content of Statistical Requirements for Authors in Biomedical Research Journals

PubMed Central

Liu, Tian-Yi; Cai, Si-Yu; Nie, Xiao-Lu; Lyu, Ya-Qi; Peng, Xiao-Xia; Feng, Guo-Shuang

2016-01-01

Background: Robust statistical designing, sound statistical analysis, and standardized presentation are important to enhance the quality and transparency of biomedical research. This systematic review was conducted to summarize the statistical reporting requirements introduced by biomedical research journals with an impact factor of 10 or above so that researchers are able to give statistical issues’ serious considerations not only at the stage of data analysis but also at the stage of methodological design. Methods: Detailed statistical instructions for authors were downloaded from the homepage of each of the included journals or obtained from the editors directly via email. Then, we described the types and numbers of statistical guidelines introduced by different press groups. Items of statistical reporting guideline as well as particular requirements were summarized in frequency, which were grouped into design, method of analysis, and presentation, respectively. Finally, updated statistical guidelines and particular requirements for improvement were summed up. Results: Totally, 21 of 23 press groups introduced at least one statistical guideline. More than half of press groups can update their statistical instruction for authors gradually relative to issues of new statistical reporting guidelines. In addition, 16 press groups, covering 44 journals, address particular statistical requirements. The most of the particular requirements focused on the performance of statistical analysis and transparency in statistical reporting, including “address issues relevant to research design, including participant flow diagram, eligibility criteria, and sample size estimation,” and “statistical methods and the reasons.” Conclusions: Statistical requirements for authors are becoming increasingly perfected. Statistical requirements for authors remind researchers that they should make sufficient consideration not only in regards to statistical methods during the research design, but also standardized statistical reporting, which would be beneficial in providing stronger evidence and making a greater critical appraisal of evidence more accessible. PMID:27748343

The Content of Statistical Requirements for Authors in Biomedical Research Journals.

PubMed

Liu, Tian-Yi; Cai, Si-Yu; Nie, Xiao-Lu; Lyu, Ya-Qi; Peng, Xiao-Xia; Feng, Guo-Shuang

2016-10-20

Robust statistical designing, sound statistical analysis, and standardized presentation are important to enhance the quality and transparency of biomedical research. This systematic review was conducted to summarize the statistical reporting requirements introduced by biomedical research journals with an impact factor of 10 or above so that researchers are able to give statistical issues' serious considerations not only at the stage of data analysis but also at the stage of methodological design. Detailed statistical instructions for authors were downloaded from the homepage of each of the included journals or obtained from the editors directly via email. Then, we described the types and numbers of statistical guidelines introduced by different press groups. Items of statistical reporting guideline as well as particular requirements were summarized in frequency, which were grouped into design, method of analysis, and presentation, respectively. Finally, updated statistical guidelines and particular requirements for improvement were summed up. Totally, 21 of 23 press groups introduced at least one statistical guideline. More than half of press groups can update their statistical instruction for authors gradually relative to issues of new statistical reporting guidelines. In addition, 16 press groups, covering 44 journals, address particular statistical requirements. The most of the particular requirements focused on the performance of statistical analysis and transparency in statistical reporting, including "address issues relevant to research design, including participant flow diagram, eligibility criteria, and sample size estimation," and "statistical methods and the reasons." Statistical requirements for authors are becoming increasingly perfected. Statistical requirements for authors remind researchers that they should make sufficient consideration not only in regards to statistical methods during the research design, but also standardized statistical reporting, which would be beneficial in providing stronger evidence and making a greater critical appraisal of evidence more accessible.

Expected net present value of sample information: from burden to investment.

PubMed

Hall, Peter S; Edlin, Richard; Kharroubi, Samer; Gregory, Walter; McCabe, Christopher

2012-01-01

The Expected Value of Information Framework has been proposed as a method for identifying when health care technologies should be immediately reimbursed and when any reimbursement should be withheld while awaiting more evidence. This framework assesses the value of obtaining additional evidence to inform a current reimbursement decision. This represents the burden of not having the additional evidence at the time of the decision. However, when deciding whether to reimburse now or await more evidence, decision makers need to know the value of investing in more research to inform a future decision. Assessing this value requires consideration of research costs, research time, and what happens to patients while the research is undertaken and after completion. The investigators describe a development of the calculation of the expected value of sample information that assesses the value of investing in further research, including an only-in-research strategy and an only-with-research strategy.

Commercial aviation icing research requirements

NASA Technical Reports Server (NTRS)

Koegeboehn, L. P.

1981-01-01

A short range and long range icing research program was proposed. A survey was made to various industry and goverment agencies to obtain their views of needs for commercial aviation ice protection. Through these responsed, other additional data, and Douglas Aircraft icing expertise; an assessment of the state-of-the-art of aircraft icing data and ice protection systems was made. The information was then used to formulate the icing research programs.

75 FR 59935 - Investigational New Drug Safety Reporting Requirements for Human Drug and Biological Products and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... safety reporting for human drug products: Janet Norden, Center for Drug Evaluation and Research, Food and... for Biologics Evaluation and Research, Food and Drug Administration,1401 Rockville Pike, suite 200N..., 2003. At the request of industry, and to provide all interested persons additional time to comment, the...

THz Spectroscopy and Spectroscopic Database for Astrophysics

NASA Technical Reports Server (NTRS)

Pearson, John C.; Drouin, Brian J.

2006-01-01

Molecule specific astronomical observations rely on precisely determined laboratory molecular data for interpretation. The Herschel Heterodyne Instrument for Far Infrared, a suite of SOFIA instruments, and ALMA are each well placed to expose the limitations of available molecular physics data and spectral line catalogs. Herschel and SOFIA will observe in high spectral resolution over the entire far infrared range. Accurate data to previously unimagined frequencies including infrared ro-vibrational and ro-torsional bands will be required for interpretation of the observations. Planned ALMA observations with a very small beam will reveal weaker emission features requiring accurate knowledge of higher quantum numbers and additional vibrational states. Historically, laboratory spectroscopy has been at the front of submillimeter technology development, but now astronomical receivers have an enormous capability advantage. Additionally, rotational spectroscopy is a relatively mature field attracting little interest from students and funding agencies. Molecular database maintenance is tedious and difficult to justify as research. This severely limits funding opportunities even though data bases require the same level of expertise as research. We report the application of some relatively new receiver technology into a simple solid state THz spectrometer that has the performance required to collect the laboratory data required by astronomical observations. Further detail on the lack of preparation for upcoming missions by the JPL spectral line catalog is given.

THz Spectroscopy and Spectroscopic Database for Astrophysics

NASA Technical Reports Server (NTRS)

Pearson, John C.; Drouin, Brian J.

2006-01-01

Molecule specific astronomical observations rely on precisely determined laboratory molecular data for interpretation. The Herschel Heterodyne Instrument for Far Infrared, a suite of SOFIA instruments, and ALMA are each well placed to expose the limitations of available molecular physics data and spectral line catalogs. Herschel and SOFIA will observe in high spectral resolution over the entire far infrared range. Accurate data to previously unimagined frequencies including infrared ro-vibrational and ro-torsional bands will be required for interpretation of the observations. Planned ALMA observations with a very small beam will reveal weaker emission features requiring accurate knowledge of higher quantum numbers and additional vibrational states. Historically, laboratory spectroscopy has been at the front of submillimeter technology development, but now astronomical receivers have an enormous capability advantage. Additionally, rotational spectroscopy is a relatively mature field attracting little interest from students and funding agencies. Molecular data base maintenance is tedious and difficult to justify as research. This severely limits funding opportunities even though data bases require the same level of expertise as research. We report the application of some relatively new receiver technology into a simple solid state THz spectrometer that has the performance required to collect the laboratory data required by astronomical observations. Further detail on the lack of preparation for upcoming missions by the JPL spectral line catalog is given.

Water-quality requirements, tolerances, and preferences of pallid sturgeon (Scaphirhynchus albus) in the lower Missouri River

USGS Publications Warehouse

Blevins, Dale W.

2011-01-01

Additional research could be used to characterize and quantify the requirements, tolerance, and preferences of pallid sturgeon to these water-quality characteristics, especially during the egg and larval life stages. Enhancements to existing water-sampling programs are needed to quantify the exposure of pallid sturgeon to many of these water-quality stressors.

10 CFR 603.885 - Updated program plans and budgets.

Code of Federal Regulations, 2011 CFR

2011-01-01

... program plans and budgets. In addition to reports on progress to date, a TIA may include a provision requiring the recipient to annually prepare an updated technical plan for future conduct of the research...

Federal Guidance Report No. 1: Background Material for the Development of Radiation Protection Standards (Federal Radiation Council)

EPA Pesticide Factsheets

This report provides required interim radiation protection recommendations. It includes recommendations for additional research which will provide a firmer basis for the formulation of radiation standards.

The Sulfur Cycle

ERIC Educational Resources Information Center

Kellogg, W. W.; And Others

1972-01-01

A model estimating the contributions of sulfur compounds by natural and human activities, and the rate of removal of sulfur from the atmosphere, is based on a review of the existing literature. Areas requiring additional research are identified. (AL)

Back to the Basics: An Investigation of School- and District-Level Remediation Efforts Associated with Minnesota's Basic Standards for High School Graduation.

ERIC Educational Resources Information Center

Schleisman, Jane L.; Peterson, Kristin A.; Davison, Mark L.

This report describes an investigation of the types of additional instructional opportunities and remediation efforts provided by Minnesota schools and districts for students who do not initially meet basic skill requirements in reading and/or mathematics in eighth grade. Primary research questions included: What additional instructional…

Tier One Performance Screen Initial Operational Test and Evaluation: 2010 Annual Report

DTIC Science & Technology

2011-10-01

ANNUAL REPORT EXECUTIVE SUMMARY Research Requirement: In addition to educational, physical , and moral screens, the U.S. Army relies on a...number of criteria of interest. Most notably, the Physical Conditioning scale predicted Soldiers’ self- reported Army Physical Fitness Test (APFT...individual Soldier through maximally effective selection, classification, and retention strategies. In addition to educational, physical , and moral

77 FR 72511 - Approval, Disapproval and Promulgation of Air Quality Implementation Plans; Arizona; Regional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... Consulting & Research, Inc. (57) The initials RMC mean or refer to Regional Modeling Center. (58) The... whether an alternative test method to the one required in the SIP is acceptable for PM 10. In addition, we..., we allow the use of Method 5 as an alternative to Method 201A/202. In addition, the FIP includes a...

Experience with Ada on the F-18 High Alpha Research Vehicle Flight Test Program

NASA Technical Reports Server (NTRS)

Regenie, Victoria A.; Earls, Michael; Le, Jeanette; Thomson, Michael

1992-01-01

Considerable experience was acquired with Ada at the NASA Dryden Flight Research Facility during the on-going High Alpha Technology Program. In this program, an F-18 aircraft was highly modified by the addition of thrust-vectoring vanes to the airframe. In addition, substantial alteration was made in the original quadruplex flight control system. The result is the High Alpha Research Vehicle. An additional research flight control computer was incorporated in each of the four channels. Software for the research flight control computer was written in Ada. To date, six releases of this software have been flown. This paper provides a detailed description of the modifications to the research flight control system. Efficient ground-testing of the software was accomplished by using simulations that used the Ada for portions of their software. These simulations are also described. Modifying and transferring the Ada for flight software to the software simulation configuration has allowed evaluation of this language. This paper also discusses such significant issues in using Ada as portability, modifiability, and testability as well as documentation requirements.

Experience with Ada on the F-18 High Alpha Research Vehicle flight test program

NASA Technical Reports Server (NTRS)

Regenie, Victoria A.; Earls, Michael; Le, Jeanette; Thomson, Michael

1994-01-01

Considerable experience has been acquired with Ada at the NASA Dryden Flight Research Facility during the on-going High Alpha Technology Program. In this program, an F-18 aircraft has been highly modified by the addition of thrust-vectoring vanes to the airframe. In addition, substantial alteration was made in the original quadruplex flight control system. The result is the High Alpha Research Vehicle. An additional research flight control computer was incorporated in each of the four channels. Software for the research flight control computer was written Ada. To date, six releases of this software have been flown. This paper provides a detailed description of the modifications to the research flight control system. Efficient ground-testing of the software was accomplished by using simulations that used the Ada for portions of their software. These simulations are also described. Modifying and transferring the Ada flight software to the software simulation configuration has allowed evaluation of this language. This paper also discusses such significant issues in using Ada as portability, modifiability, and testability as well as documentation requirements.

Ancillary study management systems: a review of needs

PubMed Central

2013-01-01

Background The valuable clinical data, specimens, and assay results collected during a primary clinical trial or observational study can enable researchers to answer additional, pressing questions with relatively small investments in new measurements. However, management of such follow-on, “ancillary” studies is complex. It requires coordinating across institutions, sites, repositories, and approval boards, as well as distributing, integrating, and analyzing diverse data types. General-purpose software systems that simplify the management of ancillary studies have not yet been explored in the research literature. Methods We have identified requirements for ancillary study management primarily as part of our ongoing work with a number of large research consortia. These organizations include the Center for HIV/AIDS Vaccine Immunology (CHAVI), the Immune Tolerance Network (ITN), the HIV Vaccine Trials Network (HVTN), the U.S. Military HIV Research Program (MHRP), and the Network for Pancreatic Organ Donors with Diabetes (nPOD). We also consulted with researchers at a range of other disease research organizations regarding their workflows and data management strategies. Lastly, to enhance breadth, we reviewed process documents for ancillary study management from other organizations. Results By exploring characteristics of ancillary studies, we identify differentiating requirements and scenarios for ancillary study management systems (ASMSs). Distinguishing characteristics of ancillary studies may include the collection of additional measurements (particularly new analyses of existing specimens); the initiation of studies by investigators unaffiliated with the original study; cross-protocol data pooling and analysis; pre-existing participant consent; and pre-existing data context and provenance. For an ASMS to address these characteristics, it would need to address both operational requirements (e.g., allocating existing specimens) and data management requirements (e.g., securely distributing and integrating primary and ancillary data). Conclusions The scenarios and requirements we describe can help guide the development of systems that make conducting ancillary studies easier, less expensive, and less error-prone. Given the relatively consistent characteristics and challenges of ancillary study management, general-purpose ASMSs are likely to be useful to a wide range of organizations. Using the requirements identified in this paper, we are currently developing an open-source, general-purpose ASMS based on LabKey Server (http://www.labkey.org) in collaboration with CHAVI, the ITN and nPOD. PMID:23294514

"Teach-to-Goal" to Better Assess Informed Consent Comprehension among Incarcerated Clinical Research Participants.

PubMed

Ahalt, Cyrus; Sudore, Rebecca; Bolano, Marielle; Metzger, Lia; Darby, Anna M; Williams, Brie

2017-09-01

Correctional health research requires important safeguards to ensure that research participation is ethically conducted. In addition to having disproportionately low educational attainment and low literacy, incarcerated people suffer from health-related conditions that can affect cognition (e.g., traumatic brain injury, substance use disorders, mental illness). Yet modified informed consent processes that assess participants' comprehension of the risks and benefits of participation are not required by relevant federal guidelines. A push to assess comprehension of informed consent documents is particularly timely given an increase in demand for correctional health research in the context of criminal justice reform. We argue that comprehension assessments can identify persons who should be excluded from research and help those who will ultimately participate in studies better understand the risks and benefits of their participation. © 2017 American Medical Association. All Rights Reserved.

A Systematic Review of Extramural Presentations and Publications from Pharmacy Student Research Programs

PubMed Central

Martin, Jennifer; Worede, Leah; Islam, Sameer

2016-01-01

Objective. To conduct a systematic review of reports of pharmacy student research programs that describes the programs and resulting publications or presentations. Methods. To be eligible for the review, reports had to be in English and indicate that students were required to collect, analyze data, and report or present findings. The outcome variables were extramural posters/presentations and publications. Results. Database searches resulted in identification of 13 reports for 12 programs. Two-thirds were reports of projects required for a course or for graduation, and the remaining third were elective (participation was optional). Extramural posters resulted from 75% of the programs and publications from 67%. Conclusion. Although reporting on the outcomes of student research programs is limited, three-quarters of the programs indicated that extramural presentations, publications, or both resulted from student research. Additional research is needed to identify relevant outcomes of student research programs in pharmacy. PMID:27667837

Applied high-speed imaging for the icing research program at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slater, Howard; Owens, Jay; Shin, Jaiwon

1992-01-01

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

A Systematic Review of Extramural Presentations and Publications from Pharmacy Student Research Programs.

PubMed

Slack, Marion K; Martin, Jennifer; Worede, Leah; Islam, Sameer

2016-08-25

Objective. To conduct a systematic review of reports of pharmacy student research programs that describes the programs and resulting publications or presentations. Methods. To be eligible for the review, reports had to be in English and indicate that students were required to collect, analyze data, and report or present findings. The outcome variables were extramural posters/presentations and publications. Results. Database searches resulted in identification of 13 reports for 12 programs. Two-thirds were reports of projects required for a course or for graduation, and the remaining third were elective (participation was optional). Extramural posters resulted from 75% of the programs and publications from 67%. Conclusion. Although reporting on the outcomes of student research programs is limited, three-quarters of the programs indicated that extramural presentations, publications, or both resulted from student research. Additional research is needed to identify relevant outcomes of student research programs in pharmacy.

Applied high-speed imaging for the icing research program at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slater, Howard; Owens, Jay; Shin, Jaiwon

1991-01-01

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

University role in astronaut life support systems: Extravehicular guidance and stabilization in space

NASA Technical Reports Server (NTRS)

Vonrenner, L. C.

1972-01-01

Two problem areas are reviewed: (1) the nature of and approach to the EVA mission and (2) the guidance and stabilization required of such a mission. The report indicates several broad areas in which additional research is needed to provide an advance to the state-of-the-art. Moreover, the research problems cited were chosen from among many as those most amenable to research and study in the university environment.

The Myth, the Truth, the NASA IRB

NASA Technical Reports Server (NTRS)

Covington, M. D.; Flores, M. P.; Neutzler, V. P.; Schlegel, T. T.; Platts, S. H.; Lioyd, C. W.

2017-01-01

The purpose of the NASA Institutional Review Board (IRB) is to review research activities involving human subjects to ensure that ethical standards for the care and protection of human subjects have been met and research activities are in compliance with all pertinent federal, state and local regulations as well as NASA policies. NASA IRB's primary role is the protection of human subjects in research studies. Protection of human subjects is the shared responsibility of NASA, the IRB, and the scientific investigators. Science investigators who plan to conduct NASA-funded human research involving NASA investigators, facilities, or funds must submit and coordinate their research studies for review and approval by the NASA IRB prior to initiation. The IRB has the authority to approve, require changes in, or disapprove research involving human subjects. Better knowledge of the NASA IRB policies, procedures and guidelines should help facilitate research protocol applications and approvals. In this presentation, the myths and truths of NASA IRB policies and procedures will be discussed. We will focus on the policies that guide a protocol through the NASA IRB and the procedures that principal investigators must take to obtain required IRB approvals for their research studies. In addition, tips to help ensure a more efficient IRB review will be provided. By understanding the requirements and processes, investigators will be able to more efficiently prepare their protocols and obtain the required NASA IRB approval in a timely manner.

Dredging Research Program. Dredge Mooring Study, Recommended Design, Phase 2 Report

DTIC Science & Technology

1992-05-01

describes the amount of dock space and staging area required (250 ft by 300 ft of dock space), crane requirements (a 50- to 60-ton crane ), and time and...including a diver) in 1 week or less (5 days minimum). With the addition of a second crane and second anchor handling vessel, the assembly and installation...describes the amount of dock space and staging area required (250 ft by 300 ft of dock space), crane requirements (a 50- to 60-ton crane ), and time and

Understandings of genomic research in developing countries: a qualitative study of the views of MalariaGEN participants in Mali.

PubMed

Traore, Karim; Bull, Susan; Niare, Alassane; Konate, Salimata; Thera, Mahamadou A; Kwiatkowski, Dominic; Parker, Michael; Doumbo, Ogobara K

2015-06-16

Obtaining informed consent for participation in genomic research in low-income settings presents specific ethical issues requiring attention. These include the challenges that arise when providing information about unfamiliar and technical research methods, the implications of complicated infrastructure and data sharing requirements, and the potential consequences of future research with samples and data. This study investigated researchers' and participants' parents' experiences of a consent process and understandings of a genome-wide association study of malaria involving children aged five and under in Mali. It aimed to inform best practices in recruiting participants into genomic research. A qualitative rapid ethical assessment was undertaken. Fifty-five semi-structured interviews were conducted with the parents of research participants. An additional nine semi-structured interviews were conducted with senior research scientists, research assistants and with a member of an ethics committee. A focus group with five parents of research participants and direct observations of four consent processes were also conducted. French and translated English transcripts were descriptively and thematically coded using OpenCode software. Participants' parents in the MalariaGEN study had differing understandings of the causes of malaria, the rationale for collecting blood samples, the purposes of the study and the kinds of information the study would generate. Genomic aspects of the research, including the gene/environment interaction underlying susceptibility or resistance to severe malaria, proved particularly challenging to explain and understand. This study identifies a number of areas to be addressed in the design of consent processes for genomic research, some of which require careful ethical analysis. These include determining how much information should be provided about differing aspects of the research and how best to promote understandings of genomic research. We conclude that it is important to build capacity in the design and conduct of effective and appropriate consent processes for genomic research in low and middle-income settings. Additionally, consideration should be given to the role of review committees and community consultation activities in protecting the interests of participants in genomic research.

Standardizing lightweight deflectometer modulus measurements for compaction quality assurance : research summary.

DOT National Transportation Integrated Search

2017-09-01

The mechanistic-empirical pavement design method requires the elastic resilient modulus as the key input for characterization of geomaterials. Current density-based QA procedures do not measure resilient modulus. Additionally, the density-based metho...

Live-load distribution on glued-laminated timber girder bridges : final report : conclusions and recommendations

Treesearch

Fouad Fanous; Jeremy May; Terry Wipf; Michael Ritter

2011-01-01

Increased use of timber bridges in the U.S. transportation system has required additional research to improve the current design methodology of these bridges. For this reason, the U.S. Forest Service, Forest Products Laboratory (FPL), and the Federal Highway Administration have supported several research programs to attain the objective listed above. This report is a...

A Positive Postdoctoral Experience Is Related to Quality Supervision and Career Mentoring, Collaborations, Networking and a Nurturing Research Environment

ERIC Educational Resources Information Center

Scaffidi, Amelia K.; Berman, Judith E.

2011-01-01

For postdocs to have the best chances of achieving their career goals they need to not only acquire discipline-specific research experience, but also additional generic skills vital for future employment inside or outside academia. They also require access to information and mentoring that will help them strategically plan and make informed…

Review of spectroscopic parameters for upper atmospheric measurements

NASA Technical Reports Server (NTRS)

Smith, M. A. H. (Editor)

1985-01-01

The workshop included communication of spectroscopic data requirements for the planned upper atmosphere research satellite (UARS) mission, review of the status of currently available spectroscopic parameters, and recommendation of additional studies. The objectives were accomplished and resulted in a series of general and specific recommendations for laboratory spectroscopy research to meet the needs of UARS and other atmospheric remote sensing programs.

Human Research Program Requirements Document (Revision C)

NASA Technical Reports Server (NTRS)

Vargas, Paul R.

2009-01-01

The purpose of this document is to define, document, and allocate the Human Research Program (HRP) requirements to the HRP Program Elements. It establishes the flow-down of requirements from Exploration Systems Mission Directorate (ESMD) and Office of the Chief Health and Medical Officer (OCHMO) to the various Program Elements of the HRP to ensure that human research and technology countermeasure investments are made to insure the delivery of countermeasures and technologies that satisfy ESMD's and OCHMO's exploration mission requirements. Requirements driving the HRP work and deliverables are derived from the exploration architecture, as well as Agency standards regarding the maintenance of human health and performance. Agency human health and performance standards will define acceptable risk for each type and duration of exploration mission. It is critical to have the best available scientific and clinical evidence in setting and validating these standards. In addition, it is imperative that the best available evidence on preventing and mitigating human health and performance risks is incorporated into exploration mission and vehicle designs. These elements form the basis of the HRP research and technology development requirements and highlight the importance of HRP investments in enabling NASA's exploration missions. This PRD defines the requirements of the HRP which is comprised of the following major Program Elements: Behavioral Health and Performance (BHP), Exploration Medical Capability (ExMC), Human Health Countermeasures (HHC), ISS Medical Project (ISSMP), Space Human Factors and Habitability (SHFH), and Space Radiation (SR).

Establishing pan-European clinical trials: regulatory compliance and other practical considerations.

PubMed

Grienenberger, Aurelie

2004-01-01

There are currently many concerns in the pharmaceutical and scientific community working in or around clinical research on the EU Directive 2001/20/EC or Clinical Trials Directive. The Directive introduces regulatory requirements for all phases of study in human subjects, drawing no distinction between commercially funded drug trials and non-commercial/academic research. The Directive makes Good Clinical Practice (GCP) a legal requirement in Europe and all clinical research will be subjected to the same rigorous standards including GCP and Good Manufacturing Practice (GMP) application even at the early clinical phases as well as exhaustive pharmacovigilance and protection of trial subjects. Some of these requirements may be seen as additional burden and a brake to clinical research in Europe. However, the application of the directive should provide a single and highly regulated market of 25 European countries for investigational medicinal products. This article reviews the main aspects and areas of concern of the Directive and provide US sponsor with useful references.

ELSI practices in genomic research in East Asia: implications for research collaboration and public participation

PubMed Central

2014-01-01

Common infrastructures and platforms are required for international collaborations in large-scale human genomic research and policy development, such as the Global Alliance for Genomics and Health and the ‘ELSI 2.0’ initiative. Such initiatives may require international harmonization of ethical and regulatory requirements. To enable this, however, a greater understanding of issues and practices that relate to the ethical, legal and social implications (ELSI) of genomic research will be needed for the different countries and global regions involved in such research. Here, we review the ELSI practices and regulations for genomic research in six East Asian countries (China, Indonesia, Japan, Singapore, South Korea and Taiwan), highlighting the main similarities and differences between these countries, and more generally, in relation to Western countries. While there are significant differences in ELSI practices among these East Asian countries, there is a consistent emphasis on advancing genomic science and technology. In addition, considerable emphasis is placed on informed consent for participation in research, whether through the contribution of tissue samples or personal information. However, a higher level of engagement with interested stakeholders and the public will be needed in some countries. PMID:24944586

Association of a Biweekly Research Workgroup With Enhanced Resident Research Productivity.

PubMed

Brackmann, Melissa; Reynolds, R Kevin; Uppal, Shitanshu; McLean, Karen

2016-09-01

Almost all residency programs require a resident research project, yet teaching and mentoring of the required skills are often lacking. We established an every-other-week gynecologic oncology research workgroup at our institution for obstetrics and gynecology faculty, fellows, and residents with the goal of increasing resident research education, involvement, and productivity. An informal, discussion-style format was adopted as a forum for brainstorming research ideas, formulating study protocols, and collaborating on institutional review board submissions. Additional aims included editorial feedback on abstracts and manuscripts as well as oral presentation preparation. The academic productivity of trainees mentored by the gynecologic oncology division was queried for 27 months before and 27 months after workgroup initiation, specifically assessing resident involvement in institutional review board submission, abstract presentation, and manuscript preparation. Institution of our workgroup was associated with a dramatic increase in resident research output, including manuscript preparation and presentations at national meetings. We describe our experience because it may benefit other residency programs wishing to improve both resident research education and productivity.

Visual Purple, the Next Generation Crisis Management Decision Training Tool

DTIC Science & Technology

2001-09-01

talents of professional Hollywood screenwriters during the scripting and writing process of the simulations. Additionally, cinematic techniques learned...cultural, and language experts for research development. Additionally, GTA provides country specific support in script writing and cinematic resources as...The result is an entirely new dimension of realism that traditional exercises often fail to capture. The scenario requires the participant to make the

A tale of two perspectives: regulation versus self-regulation. A financial reporting approach (from Sarbanes-Oxley) for research ethics.

PubMed

Richman, Vincent; Richman, Alex

2012-06-01

Reports of research fraud have raised concerns about research integrity similar to concerns raised about financial accounting fraud. We propose a departure from self-regulation in that researchers adopt the financial accounting approach in establishing trust through an external validation process, in addition to the reporting entities and the regulatory agencies. The general conceptual framework for reviewing financial reports, utilizes external auditors who are certified and objective in using established standards to provide an opinion on the financial reports. These standards have become both broader in scope and increasingly specific as to what information is reported and the methodologies to be employed. We believe that the financial reporting overhaul encompassed in the US Sarbanes-Oxley Act of 2002, which aims at preventing accounting fraud, can be applied to scientific research in 4 ways. First, Sarbanes-Oxley requires corporations to have a complete set of internal accounting controls. Research organizations should use appropriate sampling techniques and audit research projects for conformity with the initial research protocols. Second, corporations are required to have the chief financial officer certify the accuracy of their financial statements. In a similar way, each research organization should have their vice-president of research (or equivalent) certify the research integrity of their research activities. In contrast, the primary responsibility of the existing Research Integrity Officers is to handle allegations of research misconduct, an after-the-fact activity. Third, generally accepted auditing standards specify the appropriate procedures for external review of a corporation's financial statements. For similar reasons, the research review process would also require corresponding external auditing standards. Finally, these new requirements would be implemented in stages, with the largest 14 research organizations that receive 25% of the total National Institutes of Health funding, adopting these research oversight enhancements first.

Combustion process science and technology

NASA Technical Reports Server (NTRS)

Hale, Robert R.

1989-01-01

An important and substantial area of technical work in which noncontact temperature measurement (NCTM) is desired is that involving combustion process research. In the planning for this workshop, it was hoped that W. Serignano would provide a briefing regarding the experimental requirements for thermal measurements to support such research. The particular features of thermal measurement requirements included those describing the timeline for combustion experiments, the requirements for thermal control and diagnostics of temperature and other related thermal measurements and the criticality to the involved science to parametric features of measurement capability including precision, repeatability, stability, and resolution. In addition, it was hoped that definitions could be provided which characterize the needs for concurrent imaging as it relates to science observations during the conduct of experimentation.

Adapting Project Management Practices to Research-Based Projects

NASA Technical Reports Server (NTRS)

Bahr, P.; Baker, T.; Corbin, B.; Keith, L.; Loerch, L.; Mullenax, C.; Myers, R.; Rhodes, B.; Skytland, N.

2007-01-01

From dealing with the inherent uncertainties in outcomes of scientific research to the lack of applicability of current NASA Procedural Requirements guidance documentation, research-based projects present challenges that require unique application of classical project management techniques. If additionally challenged by the creation of a new program transitioning from basic to applied research in a technical environment often unfamiliar with the cost and schedule constraints addressed by project management practices, such projects can find themselves struggling throughout their life cycles. Finally, supplying deliverables to a prime vehicle customer, also in the formative stage, adds further complexity to the development and management of research-based projects. The Biomedical Research and Countermeasures Projects Branch at NASA Johnson Space Center encompasses several diverse applied research-based or research-enabling projects within the newly-formed Human Research Program. This presentation will provide a brief overview of the organizational structure and environment in which these projects operate and how the projects coordinate to address and manage technical requirements. We will identify several of the challenges (cost, technical, schedule, and personnel) encountered by projects across the Branch, present case reports of actions taken and techniques implemented to deal with these challenges, and then close the session with an open forum discussion of remaining challenges and potential mitigations.

Epidemiological considerations for the use of databases in transfusion research: a Scandinavian perspective.

PubMed

Edgren, Gustaf; Hjalgrim, Henrik

2010-11-01

At current safety levels, with adverse events from transfusions being relatively rare, further progress in risk reductions will require large-scale investigations. Thus, truly prospective studies may prove unfeasible and other alternatives deserve consideration. In this review, we will try to give an overview of recent and historical developments in the use of blood donation and transfusion databases in research. In addition, we will go over important methodological issues. There are at least three nationwide or near-nationwide donation/transfusion databases with the possibility for long-term follow-up of donors and recipients. During the past few years, a large number of reports have been published utilizing such data sources to investigate transfusion-associated risks. In addition, numerous clinics systematically collect and use such data on a smaller scale. Combining systematically recorded donation and transfusion data with long-term health follow-up opens up exciting opportunities for transfusion medicine research. However, the correct analysis of such data requires close attention to methodological issues, especially including the indication for transfusion and reverse causality.

Development of a Procedure to Increase Awareness and Reporting of Counterintelligence and Terrorism Indicators: Personal Acknowledgment of Staff Security (PASS)

DTIC Science & Technology

2013-02-27

signed certification by supervisors that they understand and intend to comply with reporting policy. Recent psychological research suggests that the...intend to comply with reporting policy. Recent psychological research suggests that the additional step of requiring a signed acknowledgment may make...prepared by the Defense Personnel Security Research Center (PERSEREC) as part of an effort to design and pilot test the proposed system. This report was

Development of Airport Surface Required Navigation Performance (RNP)

NASA Technical Reports Server (NTRS)

Cassell, Rick; Smith, Alex; Hicok, Dan

1999-01-01

The U.S. and international aviation communities have adopted the Required Navigation Performance (RNP) process for defining aircraft performance when operating the en-route, approach and landing phases of flight. RNP consists primarily of the following key parameters - accuracy, integrity, continuity, and availability. The processes and analytical techniques employed to define en-route, approach and landing RNP have been applied in the development of RNP for the airport surface. To validate the proposed RNP requirements several methods were used. Operational and flight demonstration data were analyzed for conformance with proposed requirements, as were several aircraft flight simulation studies. The pilot failure risk component was analyzed through several hypothetical scenarios. Additional simulator studies are recommended to better quantify crew reactions to failures as well as additional simulator and field testing to validate achieved accuracy performance, This research was performed in support of the NASA Low Visibility Landing and Surface Operations Programs.

Large, horizontal-axis wind turbines

NASA Technical Reports Server (NTRS)

Linscott, B. S.; Perkins, P.; Dennett, J. T.

1984-01-01

Development of the technology for safe, reliable, environmentally acceptable large wind turbines that have the potential to generate a significant amount of electricity at costs competitive with conventional electric generating systems are presented. In addition, these large wind turbines must be fully compatible with electric utility operations and interface requirements. There are several ongoing large wind system development projects and applied research efforts directed toward meeting the technology requirements for utility applications. Detailed information on these projects is provided. The Mod-O research facility and current applied research effort in aerodynamics, structural dynamics and aeroelasticity, composite and hybrid composite materials, and multiple system interaction are described. A chronology of component research and technology development for large, horizontal axis wind turbines is presented. Wind characteristics, wind turbine economics, and the impact of wind turbines on the environment are reported. The need for continued wind turbine research and technology development is explored. Over 40 references are sited and a bibliography is included.

Effects of local institutional review board review on participation in national practice-based research network studies.

PubMed

Finch, Stacia A; Barkin, Shari L; Wasserman, Richard C; Dhepyasuwan, Niramol; Slora, Eric J; Sege, Robert D

2009-12-01

To describe the process and outcomes of local institutional review board (IRB) review for 2 Pediatric Research in Office Settings (PROS) studies. Pediatric Research in Office Settings conducted 2 national studies concerning sensitive topics: (1) Child Abuse Recognition Experience Study (CARES), an observational study of physician decision making, and (2) Safety Check, a violence prevention intervention trial. Institutional review board approval was secured by investigators' sites, the American Academy of Pediatrics, and practices with local IRBs. Practices were queried about IRB rules at PROS enrollment and study recruitment. Pediatric Research in Office Settings practices in 29 states. Eighty-eight PROS practices (75 IRBs). Main Exposure Local IRB presence. Local IRB presence, level of PROS assistance, IRB process, study participation, data collection completion, and minority enrollment. Practices requiring additional local IRB approval agreed to participate less than those that did not (CARES: 33% vs 52%; Safety Check: 41% vs 56%). Of the 88 practices requiring local IRB approval, 55 received approval, with nearly 50% needing active PROS help, many requiring consent changes (eg, contact name additions, local IRB approval stamps), and 87% beginning data collection. Median days to obtain approval were 81 (CARES) and 109 (Safety Check). Practices requiring local IRB approval were less likely to complete data collection but more likely to enroll minority patients. Local IRB review was associated with lower participation rates, substantial effort navigating the process (with approval universally granted without substantive changes), and data collection delays. When considering future reforms, the national human subject protections system should consider the potential redundancy and effect on generalizability, particularly regarding enrollment of poor urban children, related to local IRB review.

Human Protein and Amino Acid Requirements.

PubMed

Hoffer, L John

2016-05-01

Human protein and amino acid nutrition encompasses a wide, complex, frequently misunderstood, and often contentious area of clinical research and practice. This tutorial explains the basic biochemical and physiologic principles that underlie our current understanding of protein and amino acid nutrition. The following topics are discussed: (1) the identity, measurement, and essentiality of nutritional proteins; (2) the definition and determination of minimum requirements; (3) nutrition adaptation; (4) obligatory nitrogen excretion and the minimum protein requirement; (5) minimum versus optimum protein intakes; (6) metabolic responses to surfeit and deficient protein intakes; (7) body composition and protein requirements; (8) labile protein; (9) N balance; (10) the principles of protein and amino acid turnover, including an analysis of the controversial indicator amino acid oxidation technique; (11) general guidelines for evaluating protein turnover articles; (12) amino acid turnover versus clearance; (13) the protein content of hydrated amino acid solutions; (14) protein requirements in special situations, including protein-catabolic critical illness; (15) amino acid supplements and additives, including monosodium glutamate and glutamine; and (16) a perspective on the future of protein and amino acid nutrition research. In addition to providing practical information, this tutorial aims to demonstrate the importance of rigorous physiologic reasoning, stimulate intellectual curiosity, and encourage fresh ideas in this dynamic area of human nutrition. In general, references are provided only for topics that are not well covered in modern textbooks. © 2016 American Society for Parenteral and Enteral Nutrition.

Identification of Microbial Gene Biomarkers for in situ RDX Biodegradation

DTIC Science & Technology

2012-12-01

Additional research is required to determine reliable guidelines to inform site managers of specific field concentrations of ammonium and nitrate...Mrs. Cynthia L. Price, Research Biologist, EPED, EL, ERDC; Dr. Rick Arnseth, Project Manager / Geochemist, Tetra Tech Inc., Oak Ridge, TN; and...a biomarker of RDX degradation, as it will also be necessary for bioremediation site managers to measure soil and groundwater concentra- tions for

Helicopter precision approach capability using the Global Positioning System

NASA Technical Reports Server (NTRS)

Kaufmann, David N.

1992-01-01

The period between 1 July and 31 December, 1992, was spent developing a research plan as well as a navigation system document and flight test plan to investigate helicopter precision approach capability using the Global Positioning System (GPS). In addition, all hardware and software required for the research was acquired, developed, installed, and verified on both the test aircraft and the ground-based reference station.

Retrospective research: What are the ethical and legal requirements?

PubMed

Junod, V; Elger, B

2010-07-25

Retrospective research is conducted on already available data and/or biologic material. Whether such research requires that patients specifically consent to the use of "their" data continues to stir controversy. From a legal and ethical point of view, it depends on several factors. The main criteria to be considered are whether the data or the sample is anonymous, whether the researcher is the one who collected it and whether the patient was told of the possible research use. In Switzerland, several laws delineate the procedure to be followed. The definition of "anonymous" is open to some interpretation. In addition, it is debatable whether consent waivers that are legally admissible for data extend to research involving human biological samples. In a few years, a new Swiss federal law on human research could clarify the regulatory landscape. Meanwhile, hospital-internal guidelines may impose stricter conditions than required by federal or cantonal law. Conversely, Swiss and European ethical texts may suggest greater flexibility and call for a looser interpretation of existing laws. The present article provides an overview of the issues for physicians, scientists, ethics committee members and policy makers involved in retrospective research in Switzerland. It aims at provoking more open discussions of the regulatory problems and possible future legal and ethical solutions.

Brazilian Science and Research Integrity: Where are We? What Next?

PubMed

Vasconcelos, Sonia M R; Sorenson, Martha M; Watanabe, Edson H; Foguel, Debora; Palácios, Marisa

2015-01-01

Building a world-class scientific community requires first-class ingredients at many different levels: funding, training, management, international collaborations, creativity, ethics, and an understanding of research integrity practices. All over the world, addressing these practices has been high on the science policy agenda of major research systems. Universities have a central role in fostering a culture of research integrity, which has posed additional challenges for faculty, students and administrators - but also opportunities. In Brazil, the leading universities and governmental funding agencies are collaborating on this project, but much remains to be done.

Restraint of children with additional needs in motor vehicles: knowledge and challenges of paediatric occupational therapists in Victoria, Australia.

PubMed

Baker, Anne; Galvin, Jane; Vale, Lisa; Lindner, Helen

2012-02-01

This research project aimed to understand the challenges faced by occupational therapists when making recommendations regarding the restraint of children with additional needs in motor vehicles in Victoria, Australia. A cross-sectional survey design was used to explore current practice in relation to the prescription of motor vehicle restraints in Victoria, Australia. An electronic survey was sent to occupational therapists working with children aged from birth to 18 years in early intervention services, hospitals, schools, community services or private practice.   Challenges faced by occupational therapists related to a lack of knowledge of relevant standards and legal requirements, issues seating children with behavioural difficulties, families' inability to purchase recommended equipment and constraints as a result of funding issues. Further work is required to develop appropriate resources which support occupational therapists to make car seating recommendations for children with additional needs which comply with Australian legal requirements and standards. © 2011 The Authors. Australian Occupational Therapy Journal © 2011 Occupational Therapy Australia.

Rodent Research on the International Space Station - A Look Forward

NASA Technical Reports Server (NTRS)

Kapusta, A. B.; Smithwick, M.; Wigley, C. L.

2014-01-01

Rodent Research on the International Space Station (ISS) is one of the highest priority science activities being supported by NASA and is planned for up to two flights per year. The first Rodent Research flight, Rodent Research-1 (RR-1) validates the hardware and basic science operations (dissections and tissue preservation). Subsequent flights will add new capabilities to support rodent research on the ISS. RR-1 will validate the following capabilities: animal husbandry for up to 30 days, video downlink to support animal health checks and scientific analysis, on-orbit dissections, sample preservation in RNA. Later and formalin, sample transfer from formalin to ethanol (hindlimbs), rapid cool-down and subsequent freezing at -80 of tissues and carcasses, sample return and recovery. RR-2, scheduled for SpX-6 (Winter 20142015) will add the following capabilities: animal husbandry for up to 60 days, RFID chip reader for individual animal identification, water refill and food replenishment, anesthesia and recovery, bone densitometry, blood collection (via cardiac puncture), blood separation via centrifugation, soft tissue fixation in formalin with transfer to ethanol, and delivery of injectable drugs that require frozen storage prior to use. Additional capabilities are also planned for future flights and these include but are not limited to male mice, live animal return, and the development of experiment unique equipment to support science requirements for principal investigators that are selected for flight. In addition to the hardware capabilities to support rodent research the Crew Office has implemented a training program in generic rodent skills for all USOS crew members during their pre-assignment training rotation. This class includes training in general animal handling, euthanasia, injections, and dissections. The dissection portion of this training focuses on the dissection of the spleen, liver, kidney with adrenals, brain, eyes, and hindlimbs. By achieving and maintaining proficiency in these basic skills as part of the nominal astronaut training curriculum this allows the rodent research program to focus the mission specific crew training on scientific requirements of research and operations flow.

Legal and ethical issues in neuroimaging research: human subjects protection, medical privacy, and the public communication of research results.

PubMed

Kulynych, Jennifer

2002-12-01

Humans subjects research entails significant legal and ethical obligations. Neuroimaging researchers must be familiar with the requirements of human subjects protection, including evolving standards for the protection of privacy and the disclosure of risk in "non-therapeutic" research. Techniques for creating veridical surface renderings from volumetric anatomical imaging data raise new privacy concerns, particularly under the federal medical privacy regulation. Additionally, neuroimaging researchers must consider their obligation to communicate research results responsibly. The emerging field of neuroethics should strive to raise awareness of these issues and to involve neuroimaging researchers in the legal, ethical, and policy debates that currently surround human subjects research.

Impact of elective versus required medical school research experiences on career outcomes

PubMed Central

Weaver, Alice N; McCaw, Tyler R; Fifolt, Matthew; Hites, Lisle; Lorenz, Robin G

2018-01-01

Many US medical schools have added a scholarly or research requirement as a potential intervention to increase the number of medical students choosing to become academic physicians and physician scientists. We designed a retrospective qualitative survey study to evaluate the impact of medical school research at the University of Alabama at Birmingham (UAB) on career choices. A survey tool was developed consisting of 74 possible questions with built-in skip patterns to customize the survey to each participant. The survey was administered using the web-based program Qualtrics to UAB School of Medicine alumni graduating between 2000 and 2014. Alumni were contacted 3 times at 2-week intervals during the year 2015, resulting in 168 completed surveys (11.5% response rate). MD/PhD graduates were excluded from the study. Most respondents completed elective research, typically for reasons relating to career advancement. 24 per cent said medical school research increased their desire for research involvement in the future, a response that positively correlated with mentorship level and publication success. Although completion of medical school research was positively correlated with current research involvement, the strongest predictor for a physician scientist career was pre-existing passion for research (p=0.008). In contrast, students motivated primarily by curricular requirement were less likely to pursue additional research opportunities. Positive medical school research experiences were associated with increased postgraduate research in our study. However, we also identified a strong relationship between current research activity and passion for research, which may predate medical school. PMID:28270407

Research requirements to improve reliability of civil helicopters

NASA Technical Reports Server (NTRS)

Dougherty, J. J., III; Barrett, L. D.

1978-01-01

The major reliability problems of the civil helicopter fleet as reported by helicopter operational and maintenance personnel are documented. An assessment of each problem is made to determine if the reliability can be improved by application of present technology or whether additional research and development are required. The reliability impact is measured in three ways: (1) The relative frequency of each problem in the fleet. (2) The relative on-aircraft manhours to repair, associated with each fleet problem. (3) The relative cost of repair materials or replacement parts associated with each fleet problem. The data reviewed covered the period of 1971 through 1976 and covered only turbine engine aircraft.

The workload analysis in welding workshop

NASA Astrophysics Data System (ADS)

Wahyuni, D.; Budiman, I.; Tryana Sembiring, M.; Sitorus, E.; Nasution, H.

2018-03-01

This research was conducted in welding workshop which produces doors, fences, canopies, etc., according to customer’s order. The symptoms of excessive workload were seen from the fact of employees complaint, requisition for additional employees, the lateness of completion time (there were 11 times of lateness from 28 orders, and 7 customers gave complaints). The top management of the workshop assumes that employees’ workload was still a tolerable limit. Therefore, it was required workload analysis to determine the number of employees required. The Workload was measured by using a physiological method and workload analysis. The result of this research can be utilized by the workshop for a better workload management.

Concurrent access to a virtual microscope using a web service oriented architecture

NASA Astrophysics Data System (ADS)

Corredor, Germán.; Iregui, Marcela; Arias, Viviana; Romero, Eduardo

2013-11-01

Virtual microscopy (VM) facilitates visualization and deployment of histopathological virtual slides (VS), a useful tool for education, research and diagnosis. In recent years, it has become popular, yet its use is still limited basically because of the very large sizes of VS, typically of the order of gigabytes. Such volume of data requires efficacious and efficient strategies to access the VS content. In an educative or research scenario, several users may require to access and interact with VS at the same time, so, due to large data size, a very expensive and powerful infrastructure is usually required. This article introduces a novel JPEG2000-based service oriented architecture for streaming and visualizing very large images under scalable strategies, which in addition need not require very specialized infrastructure. Results suggest that the proposed architecture enables transmission and simultaneous visualization of large images, while it is efficient using resources and offering users proper response times.

Study Designs and Evaluation Models for Emergency Department Public Health Research

PubMed Central

Broderick, Kerry B.; Ranney, Megan L.; Vaca, Federico E.; D’Onofrio, Gail; Rothman, Richard E.; Rhodes, Karin V.; Becker, Bruce; Haukoos, Jason S.

2011-01-01

Public health research requires sound design and thoughtful consideration of potential biases that may influence the validity of results. It also requires careful implementation of protocols and procedures that are likely to translate from the research environment to actual clinical practice. This article is the product of a breakout session from the 2009 Academic Emergency Medicine consensus conference entitled “Public Health in the ED: Screening, Surveillance, and Intervention” and serves to describe in detail aspects of performing emergency department (ED)-based public health research, while serving as a resource for current and future researchers. In doing so, the authors describe methodologic features of study design, participant selection and retention, and measurements and analyses pertinent to public health research. In addition, a number of recommendations related to research methods and future investigations related to public health work in the ED are provided. Public health investigators are poised to make substantial contributions to this important area of research, but this will only be accomplished by employing sound research methodology in the context of rigorous program evaluation. PMID:20053232

Evidence Report: Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure

NASA Technical Reports Server (NTRS)

Patel, Zarana; Huff, Janice; Saha, Janapriya; Wang, Minli; Blattnig, Steve; Wu, Honglu; Cucinotta, Francis

2015-01-01

Occupational radiation exposure from the space environment may result in non-cancer or non-CNS degenerative tissue diseases, such as cardiovascular disease, cataracts, and respiratory or digestive diseases. However, the magnitude of influence and mechanisms of action of radiation leading to these diseases are not well characterized. Radiation and synergistic effects of radiation cause DNA damage, persistent oxidative stress, chronic inflammation, and accelerated tissue aging and degeneration, which may lead to acute or chronic disease of susceptible organ tissues. In particular, cardiovascular pathologies such as atherosclerosis are of major concern following gamma-ray exposure. This provides evidence for possible degenerative tissue effects following exposures to ionizing radiation in the form of the GCR or SPEs expected during long-duration spaceflight. However, the existence of low dose thresholds and dose-rate and radiation quality effects, as well as mechanisms and major risk pathways, are not well-characterized. Degenerative disease risks are difficult to assess because multiple factors, including radiation, are believed to play a role in the etiology of the diseases. As additional evidence is pointing to lower, space-relevant thresholds for these degenerative effects, particularly for cardiovascular disease, additional research with cell and animal studies is required to quantify the magnitude of this risk, understand mechanisms, and determine if additional protection strategies are required.The NASA PEL (Permissive Exposure Limit)s for cataract and cardiovascular risks are based on existing human epidemiology data. Although animal and clinical astronaut data show a significant increase in cataracts following exposure and a reassessment of atomic bomb (A-bomb) data suggests an increase in cardiovascular disease from radiation exposure, additional research is required to fully understand and quantify these adverse outcomes at lower doses (less than 0.5 gray (SI unit for ionizing radiation dosage, i.e. one joule of radiation energy per one kilogram of matter)) to facilitate risk prediction. This risk has considerable uncertainty associated with it, and no acceptable model for projecting degenerative tissue risk is currently available. In particular, risk factors such as obesity, alcohol, and tobacco use can act as confounding factors that contribute to the large uncertainties. The PELs could be violated under certain scenarios, including following a large SPE (solar proton event) or long-term GCR (galactic cosmic ray) exposure. Specifically, for a Mars mission, the accumulated dose is sufficiently high that epidemiology data and preliminary risk estimates suggest a significant risk for cardiovascular disease. Ongoing research in this area is intended to provide the evidence base for accurate risk quantification to determine criticality for extended duration missions. Data specific to the space radiation environment must be compiled to quantify the magnitude of this risk to decrease the uncertainty in current PELs and to determine if additional protection strategies are required. New research results could lead to estimates of cumulative radiation risk from CNS and degenerative tissue diseases that, when combined with the cancer risk, may have major negative impacts on mission design, costs, schedule, and crew selection. The current report amends an earlier report (Human Research Program Requirements Document, HRP-47052, Rev. C, dated Jan 2009) in order to provide an update of evidence since 2009.

Two decades of ART: improving on success through further research

PubMed Central

HOLMGREN, Christopher J.; FIGUEREDO, Márcia Cançado

2009-01-01

ABSTRACT Since the introduction of the Atraumatic Restorative Treatment (ART) approach over twenty years ago, more than 190 research publications have appeared. The last research agenda defining research priorities for ART was published in 1999. The objective of the present work was to review existing research in the context of future research priorities for ART. Material and Methods: An internet survey was conducted amongst those who had published on ART or were known to be working on the ART approach, to solicit their views as to areas of future ART research. Three broad categories were defined, namely: 1. Basic and laboratory research; 2. Clinical research, and, 3. Community, Public Health, Health Services Research. Results: A 31% response rate was achieved. The study identified a number of new areas of research as well as areas where additional research is required. These are expressed as recommendations for future ART research. Conclusions: The ART approach is based on a robust, reliable and ever-growing evidence base concerning its clinical applications which indicates that it is a reliable and quality treatment approach. In common with all other oral health care procedures, targeted applied research is required to improve the oral health care offered. PMID:21499666

Medicare Program; Prospective Payment System and Consolidated Billing for Skilled Nursing Facilities for FY 2017, SNF Value-Based Purchasing Program, SNF Quality Reporting Program, and SNF Payment Models Research. Final rule.

PubMed

2016-08-05

This final rule updates the payment rates used under the prospective payment system (PPS) for skilled nursing facilities (SNFs) for fiscal year (FY) 2017. In addition, it specifies a potentially preventable readmission measure for the Skilled Nursing Facility Value-Based Purchasing Program (SNF VBP), and implements requirements for that program, including performance standards, a scoring methodology, and a review and correction process for performance information to be made public, aimed at implementing value-based purchasing for SNFs. Additionally, this final rule includes additional polices and measures in the Skilled Nursing Facility Quality Reporting Program (SNF QRP). This final rule also responds to comments on the SNF Payment Models Research (PMR) project.

CROSS-CUTTING QA ISSUES INVOLVING GEOSPATIAL SCIENCES, CHEMISTRY, INFORMATION MANAGEMENT, AND LAW

EPA Science Inventory

The Agency spends hundreds of millions of dollars annually collecting and processing environmental data for scientific research and regulatory decision making. In addition, the regulated community may spend as much or more each year responding to Agency compliance requirements. ...

Advancing the Evidence Base of Rehabilitation Treatments: A Developmental Approach

PubMed Central

Whyte, John; Barrett, A.M.

2013-01-01

Translational research refers to the development of new scientific discoveries into evidence-based treatments for human diseases and conditions. This developmental process requires that a number of scientific, as well as social and psychological obstacles, be overcome during a sequence of research stages that address different goals. Rehabilitation, like other biomedical disciplines, requires this kind of developmental process. For a variety of reasons, however, development of rehabilitation treatments is less linear than the familiar phases of pharmaceutical research. In addition, research on treatments intended to address impairments (body structure/function, in terms of the International Classification of Functioning, Disability and Health), faces the challenge of determining the likely impact of an impairment-level treatment on the multifaceted activities and aspects of participation that are the typical goals of rehabilitation treatments. This article describes the application of treatment theory and enablement theory to the development of new impairment-based treatments, and examines similarities and differences between the developmental sequence needed for rehabilitation treatment research versus pharmaceutical research in other areas of medicine. PMID:22683206

Additives for cement compositions based on modified peat

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kopanitsa, Natalya, E-mail: kopanitsa@mail.ru; Sarkisov, Yurij, E-mail: sarkisov@tsuab.ru; Gorshkova, Aleksandra, E-mail: kasatkina.alexandra@gmail.com

High quality competitive dry building mixes require modifying additives for various purposes to be included in their composition. There is insufficient amount of quality additives having stable properties for controlling the properties of cement compositions produced in Russia. Using of foreign modifying additives leads to significant increasing of the final cost of the product. The cost of imported modifiers in the composition of the dry building mixes can be up to 90% of the material cost, depending on the composition complexity. Thus, the problem of import substitution becomes relevant, especially in recent years, due to difficult economic situation. The articlemore » discusses the possibility of using local raw materials as a basis for obtaining dry building mixtures components. The properties of organo-mineral additives for cement compositions based on thermally modified peat raw materials are studied. Studies of the structure and composition of the additives are carried out by physicochemical research methods: electron microscopy and X-ray analysis. Results of experimental research showed that the peat additives contribute to improving of cement-sand mortar strength and hydrophysical properties.« less

Things That Scientists Don't Understand About NASA Spaceflight Research

NASA Technical Reports Server (NTRS)

Platts, S. H.; Bauer, Terri; Rogers, Shanna

2017-01-01

So you want to conduct human spaceflight research aboard the International Space Station (ISS)? Once your spaceflight research aboard the ISS is proposal is funded.... the real work begins. Because resources are so limited for ISS research, it is necessary to maximize the work being done, while at the same time, minimizing the resources spent. Astronauts may be presented with over 30 human research experiments and select, on average approximately 15 in which to participate. In order to conduct this many studies, ISSMP uses the study requirements provided by the principle investigator to integrate all of this work into the astronauts' complement. The most important thing for investigators to convey to the ISSMP team is their RESEARCH REQUIREMENTS. Requirements are captured in the Experiment document. This document is the official record of how, what, where and when data will be collected. One common mistake that investigators make is not taking this document seriously, but when push comes to shove, if a research requirement is not in this document....it will not get done. The research requirements are then integrated to form a complement of research for each astronaut. What do we mean by integration? Many experiments have overlapping requirements; blood draws, behavioral surveys, heart rate measurement. Where possible, these measures are combined to reduce redundancy and save crew time. Investigators can access these data via data sharing agreements. More examples of how ISS research is integrated will be presented. There are additional limitations commonly associated with human spaceflight research that will also be discussed. Large/heavy hardware, invasive procedures, and toxic reagents are extremely difficult to implement on the ISS. There are strict limits placed on the amount of blood that can be drawn from crew members during (and immediately after) spaceflight. These limits are based on 30-day rolling accumulations. We have recently had to start restricting studies due to this limit. The NASA Human Research Program (HRP) provides extensive support, via ISSMP, to help investigators cope with all of the intricacies of conducting human spaceflight research. This presentation will help you take the best advantage of that support.

Future experimental needs to support applied aerodynamics - A transonic perspective

NASA Technical Reports Server (NTRS)

Gloss, Blair B.

1992-01-01

Advancements in facilities, test techniques, and instrumentation are needed to provide data required for the development of advanced aircraft and to verify computational methods. An industry survey of major users of wind tunnel facilities at Langley Research Center (LaRC) was recently carried out to determine future facility requirements, test techniques, and instrumentation requirements; results from this survey are reflected in this paper. In addition, areas related to transonic testing at LaRC which are either currently being developed or are recognized as needing improvements are discussed.

[Research in space environmental medicine: review and future].

PubMed

Yu, Xue-jun; Qi, Zhang-nian; Chang, Shao-yong; Liang, Hong; Liu, Hong-tao

2003-01-01

The investigation progress of space environmental medicine in China is summarized. Then, the application of space environmental medicine to formulating medical requirements for the crew module design, and performing medical evaluation for Shenzhou spaceship are addressed. Additionally, the medical and engineering means for the protection from harmful agents during spaceflight is illustrated. Finally, the objective and challenge of space environment medicine faced in the future research in China are presented.

Optimization of Ultrasonic Fabric Cleaning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hand, T.E.

The fundamental purpose of this project was to research and develop a process that would reduce the cost and improve the environmental efficiency of the present dry-cleaning industry. This second phase of research (see report KCP-94-1006 for information gathered during the first phase) was intended to allow the optimal integration of all factors of ultrasonic fabric cleaning. For this phase, Garment Care performed an extensive literature search and gathered data from other researchers worldwide. The Garment Care-AlliedSignal team developed the requirements for a prototype cleaning tank for studies and acquired that tank and the additional equipment required to use itmore » properly. Garment Care and AlliedSignal acquired the transducers and generators from Surftran Martin-Walter in Sterling Heights, Michigan. Amway's Kelly Haley developed the test protocol, supplied hundreds of test swatches, gathered the data on the swatches before and after the tests, assisted with the cleaning tests, and prepared the final analysis of the results. AlliedSignal personnel, in conjunction with Amway and Garment Care staff, performed all the tests. Additional planning is under way for future testing by outside research facilities. The final results indicated repeatable performance and good results for single layered fabric swatches. Swatches that were cleaned as a ''sandwich,'' that is, three or more layers.« less

Modelling of flame propagation in the gasoline fuelled Wankel rotary engine with hydrogen additives

NASA Astrophysics Data System (ADS)

Fedyanov, E. A.; Zakharov, E. A.; Prikhodkov, K. V.; Levin, Y. V.

2017-02-01

Recently, hydrogen has been considered as an alternative fuel for a vehicles power unit. The Wankel engine is the most suitable to be adapted to hydrogen feeding. A hydrogen additive helps to decrease incompleteness of combustion in the volumes near the apex of the rotor. Results of theoretical researches of the hydrogen additives influence on the flame propagation in the combustion chamber of the Wankel rotary engine are presented. The theoretical research shows that the blend of 70% gasoline with 30% hydrogen could accomplish combustion near the T-apex in the stoichiometric mixture and in lean one. Maps of the flame front location versus the angle of rotor rotation and hydrogen fraction are obtained. Relations of a minimum required amount of hydrogen addition versus the engine speed are shown on the engine modes close to the average city driving cycle. The amount of hydrogen addition that could be injected by the nozzle with different flow sections is calculated in order to analyze the capacity of the feed system.

National institute for Food and Agriculture: novel and changing funding strategies and mechanisms in response to changes in budgets, legislative authorities and scientific culture

NASA Astrophysics Data System (ADS)

Cavallaro, N.; Melnick, R.

2017-12-01

Farm Bill legislation establishes different funding mechanisms managed by the National Institute of Food and Agriculture (NIFA), which have changed over the years through reauthorization. Other legislation and executive initiatives, as well as recognition by both funders, funding recipients, private organizations, and non-government organizations have stressed the need for multi-, inter-, and trans-disciplinary research and outreach. This presentation will discuss how changes to NIFA legislative authority as well as changing needs and culture in the government and the scientific research community have led to new mechanisms and strategies for types of funded projects, eligibility for NIFA funding, interagency funding, and iterative changes in direction in research solicitations. For example, limited funding for important topics has prompted a need for interagency collaborations in research funding solicitations and jointly funded projects. New legislative authorities and requirements have led to new modes of collaboration with private industry, NGOs and commodity boards along with international alliances. Unlike most funding agencies, NIFA funds education and extension or outreach projects in addition to research projects. New authorities together with increased recognition of scientific research needed to inform societal challenges has led to new thinking and greater flexibility in funding for long-term research projects and larger regional, multi-institutional and multi-national projects. This, in addition to a shifting culture among researchers and research institutions, has aided in new policies, requirements and initiatives among research institutions and government agencies involving information, data sharing and public access. Examples of new mechanisms and programs and their successes along with their drawbacks will be presented.

Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and Regional Malaria Elimination Strategies

PubMed Central

Conn, Jan E.; Norris, Douglas E.; Donnelly, Martin J.; Beebe, Nigel W.; Burkot, Thomas R.; Coulibaly, Mamadou B.; Chery, Laura; Eapen, Alex; Keven, John B.; Kilama, Maxwell; Kumar, Ashwani; Lindsay, Steve W.; Moreno, Marta; Quinones, Martha; Reimer, Lisa J.; Russell, Tanya L.; Smith, David L.; Thomas, Matthew B.; Walker, Edward D.; Wilson, Mark L.; Yan, Guiyun

2015-01-01

The unprecedented global efforts for malaria elimination in the past decade have resulted in altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities in malaria transmission require innovative vector control strategies in addition to the established practices of long-lasting insecticidal nets and indoor residual spraying. Integrated vector management will require focal and tailored vector control to achieve malaria elimination. This switch of emphasis from universal coverage to universal coverage plus additional interventions will be reliant on improved entomological monitoring and evaluation. In 2010, the National Institutes for Allergies and Infectious Diseases (NIAID) established a network of malaria research centers termed ICEMRs (International Centers for Excellence in Malaria Research) expressly to develop this evidence base in diverse malaria endemic settings. In this article, we contrast the differing ecology and transmission settings across the ICEMR study locations. In South America, Africa, and Asia, vector biologists are already dealing with many of the issues of pushing to elimination such as highly focal transmission, proportionate increase in the importance of outdoor and crepuscular biting, vector species complexity, and “sub patent” vector transmission. PMID:26259942

Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and Regional Malaria Elimination Strategies.

PubMed

Conn, Jan E; Norris, Douglas E; Donnelly, Martin J; Beebe, Nigel W; Burkot, Thomas R; Coulibaly, Mamadou B; Chery, Laura; Eapen, Alex; Keven, John B; Kilama, Maxwell; Kumar, Ashwani; Lindsay, Steve W; Moreno, Marta; Quinones, Martha; Reimer, Lisa J; Russell, Tanya L; Smith, David L; Thomas, Matthew B; Walker, Edward D; Wilson, Mark L; Yan, Guiyun

2015-09-01

The unprecedented global efforts for malaria elimination in the past decade have resulted in altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities in malaria transmission require innovative vector control strategies in addition to the established practices of long-lasting insecticidal nets and indoor residual spraying. Integrated vector management will require focal and tailored vector control to achieve malaria elimination. This switch of emphasis from universal coverage to universal coverage plus additional interventions will be reliant on improved entomological monitoring and evaluation. In 2010, the National Institutes for Allergies and Infectious Diseases (NIAID) established a network of malaria research centers termed ICEMRs (International Centers for Excellence in Malaria Research) expressly to develop this evidence base in diverse malaria endemic settings. In this article, we contrast the differing ecology and transmission settings across the ICEMR study locations. In South America, Africa, and Asia, vector biologists are already dealing with many of the issues of pushing to elimination such as highly focal transmission, proportionate increase in the importance of outdoor and crepuscular biting, vector species complexity, and "sub patent" vector transmission. © The American Society of Tropical Medicine and Hygiene.

Effects of radiobiological uncertainty on shield design for a 60-day lunar mission

NASA Technical Reports Server (NTRS)

Wilson, John W.; Nealy, John E.; Schimmerling, Walter

1993-01-01

Some consequences of uncertainties in radiobiological risk due to galactic cosmic ray exposure are analyzed to determine their effect on engineering designs for a first lunar outpost - a 60-day mission. Quantitative estimates of shield mass requirements as a function of a radiobiological uncertainty factor are given for a simplified vehicle structure. The additional shield mass required for compensation is calculated as a function of the uncertainty in galactic cosmic ray exposure, and this mass is found to be as large as a factor of 3 for a lunar transfer vehicle. The additional cost resulting from this mass is also calculated. These cost estimates are then used to exemplify the cost-effectiveness of research.

Return of Individual Research Results and Incidental Findings in the Clinical Trials Cooperative Group Setting

PubMed Central

Ferriere, Michael; Van Ness, Brian

2013-01-01

The NCI funded cooperative group cancer clinical trial system develops experimental therapies and often collects patient samples for correlative research. The Cooperative Group Bank (CGB) system maintains biobanks with a current policy not to return research results to individuals. An online survey was created, and 10 directors of CGBs completed the surveys asking about understanding and attitudes in changing policies to consider return of Incidental Findings (IFs) and Individual Research Results (IRRs) of health significance. The potential impact of the ten consensus recommendations of Wolf et al. presented in this issue are examined. Re-identification of samples is often not problematic; however, changes to the current banking and clinical trial systems would require significant effort to fulfill an obligation of recontact of subjects. Additional resources, as well as a national advisory board would be required to standardize implementation. PMID:22382800

Recommendation for Land Use Impact Assessment: First Steps into Framework, Theory, and Implementation

EPA Science Inventory

Although early Life Cycle Assessment (LCA) methodology researchers focused on the modeling of impacts from chemical emissions, it has become obvious that resource depletion categories such as land use, water use, and fossil fuel depletion require additional attention to appropria...

State Funding Mechanisms for English Language Learners

ERIC Educational Resources Information Center

Millard, Maria

2015-01-01

Research is clear that English language learners (ELLs) perform better academically and achieve greater language proficiency when they have high-quality English language instruction.1 Like all supplemental services, these necessary supports require additional funding above the average per-student amount. The federal government provides grant…

Experimental effective intensity of steady and flashing light emitting diodes for aircraft anti-collision lighting.

DOT National Transportation Integrated Search

2013-08-01

Research was conducted to determine the effective intensity of flashing lights that incorporate light-emitting diodes (LEDs). LEDs require less power and have the ability to flash without the addition of moving parts. Compared with incandescent bulbs...

The study of the mission instruments of GOSAT-2

NASA Astrophysics Data System (ADS)

Suto, H.; Nakajima, M.; Kuze, A.; Shiomi, K.; Shimoda, H.

2012-12-01

Greenhouse Gases Observing Satellite "GOSAT" was launched in January of 2009 and have observed the carbon dioxide and the methane almost four years. Additionally, the Level 1B algorithm has been improved based on the on board calibration and ground test using Engineering model and the accuracy of the level 1B data, that is the spectrum, has been improved. This has led to the more accurate calculation of the concentration of carbon dioxide and methane with small bias. At the same time, some issues have become clearer little by little through the on orbit operation. Especially a lot of data have been affected by the cloud, so few data have been used until now. However, the satellite has come to be recognized as an effective means of the detection of the global distribution of the greenhouse gases concentration. And in addition to the effort to resolve the issues which have become clear until now, the improvement of the observation performance have been required by a lot of users. Therefore, we researched the concrete requirements of users and set the mission requirements for GOSAT-2. Based on this mission requirement, we have studied the possibilities of these requirements. This study was implemented as premises for the usage of the Fourier Transform Spectrometer to detect the greenhouse gases as well as GOSAT. We considered the methods to increase the number of the useful data. For example, the reduction of the footprints size, increase of the number of the IFOV, the intelligent pointing and so on. It's necessary to maintain the Signal to Noise ration of the GOSAT. In addition to the method to increase the number of the useful data, we have researched the size of the aperture of the optics to maintain the signal to noise ratio corresponding to the reduction of the footprint seize. But the possibility of the corner cube used in the Fourier transform spectrometer limits the aperture size. We decided the aperture size (and corner cube size) based on the trade-off among corner cube size, footprint size and signal to noise ratio and the opinions of the scientists. In addition to the improvements of the performaces, the following requirements has been presented. To evaluate the relative matters of the anthropogenic emissions, to contribute to the MRV of REDD+ and so on. In order to meet these requirements the Fourier Transform Spectrometer on GOSAT-2 will has the additional observation channel for the carbon monoxide and Imager will has the spectrometer using the grating for Nitorgen Dioxide. Now we are investigating the possibilities of these additional functions and increase of the performances and we will decide the specifications of GOSAT-2 within one year.

Applying environmental product design to biomedical products research.

PubMed Central

Messelbeck, J; Sutherland, L

2000-01-01

The principal themes for the Biomedical Research and the Environment Conference Committee on Environmental Economics in Biomedical Research include the following: healthcare delivery companies and biomedical research organizations, both nonprofit and for-profit, need to improve their environmental performance; suppliers of healthcare products will be called upon to support this need; and improving the environmental profile of healthcare products begins in research and development (R&D). The committee report begins with requirements from regulatory authorities (e.g., U.S. Environmental Protection Agency [EPA], the U.S. Food and Drug Administration), and the healthcare delivery sector). The 1998 American Hospital Association and EPA Memorandum of Understanding to reduce solid waste and mercury from healthcare facilities is emblematic of these requirements. The dominant message from the requirements discussion is to ensure that R&D organizations do not ignore customer, environmental, and regulatory requirements in the early stages of product development. Several representatives from healthcare products manufacturers presented their companies' approaches to meeting these requirements. They reported on efforts to ensure that their R&D processes are sensitive to the environmental consequences from manufacturing, distributing, using, and disposing of healthcare products. These reports describe representatives' awareness of requirements and the unique approaches their R&D organizations have taken to meet these requirements. All representatives reported that their R&D organizations have embraced environmental product design because it avoids the potential of returning products to R&D to improve the environmental profile. Additionally, several reports detailed cost savings, sustainability benefits, and improvements in environmental manufacturing or redesign, and increased customer satisfaction. Many companies in healthcare delivery are working to improve environmental performance. Fundamental to these efforts is the necessity of motivating suppliers to improve the environmental profile of new products used in the healthcare delivery sector. PMID:11121364

Applying environmental product design to biomedical products research.

PubMed

Messelbeck, J; Sutherland, L

2000-12-01

The principal themes for the Biomedical Research and the Environment Conference Committee on Environmental Economics in Biomedical Research include the following: healthcare delivery companies and biomedical research organizations, both nonprofit and for-profit, need to improve their environmental performance; suppliers of healthcare products will be called upon to support this need; and improving the environmental profile of healthcare products begins in research and development (R&D). The committee report begins with requirements from regulatory authorities (e.g., U.S. Environmental Protection Agency [EPA], the U.S. Food and Drug Administration), and the healthcare delivery sector). The 1998 American Hospital Association and EPA Memorandum of Understanding to reduce solid waste and mercury from healthcare facilities is emblematic of these requirements. The dominant message from the requirements discussion is to ensure that R&D organizations do not ignore customer, environmental, and regulatory requirements in the early stages of product development. Several representatives from healthcare products manufacturers presented their companies' approaches to meeting these requirements. They reported on efforts to ensure that their R&D processes are sensitive to the environmental consequences from manufacturing, distributing, using, and disposing of healthcare products. These reports describe representatives' awareness of requirements and the unique approaches their R&D organizations have taken to meet these requirements. All representatives reported that their R&D organizations have embraced environmental product design because it avoids the potential of returning products to R&D to improve the environmental profile. Additionally, several reports detailed cost savings, sustainability benefits, and improvements in environmental manufacturing or redesign, and increased customer satisfaction. Many companies in healthcare delivery are working to improve environmental performance. Fundamental to these efforts is the necessity of motivating suppliers to improve the environmental profile of new products used in the healthcare delivery sector.

Impact of elective versus required medical school research experiences on career outcomes.

PubMed

Weaver, Alice N; McCaw, Tyler R; Fifolt, Matthew; Hites, Lisle; Lorenz, Robin G

2017-06-01

Many US medical schools have added a scholarly or research requirement as a potential intervention to increase the number of medical students choosing to become academic physicians and physician scientists. We designed a retrospective qualitative survey study to evaluate the impact of medical school research at the University of Alabama at Birmingham (UAB) on career choices. A survey tool was developed consisting of 74 possible questions with built-in skip patterns to customize the survey to each participant. The survey was administered using the web-based program Qualtrics to UAB School of Medicine alumni graduating between 2000 and 2014. Alumni were contacted 3 times at 2-week intervals during the year 2015, resulting in 168 completed surveys (11.5% response rate). MD/PhD graduates were excluded from the study. Most respondents completed elective research, typically for reasons relating to career advancement. 24 per cent said medical school research increased their desire for research involvement in the future, a response that positively correlated with mentorship level and publication success. Although completion of medical school research was positively correlated with current research involvement, the strongest predictor for a physician scientist career was pre-existing passion for research (p=0.008). In contrast, students motivated primarily by curricular requirement were less likely to pursue additional research opportunities. Positive medical school research experiences were associated with increased postgraduate research in our study. However, we also identified a strong relationship between current research activity and passion for research, which may predate medical school. Copyright © 2017 American Federation for Medical Research.

[Biobanking requirements from the perspective of the clinician : Experiences in hematology and oncology].

PubMed

Koschmieder, S; Brümmendorf, T H

2018-04-05

The requirements for optimal biobanking from the point of view of the clinical partner can be highly variable. Depending on the material, processing, storage conditions, clinical data, and involvement of external partners, there will be special requirements for the participating clinician and specialist areas. What they all have in common is that the goal of any biobanking must be to improve clinical, translational, and basic research. While in the past biomaterials often had to be individually stored for each research project, modern biobanking offers decisive advantages: a comprehensive ethics vote fulfilling state-of-the-art data safety requirements, standardized processing and storage protocols, specialized biobank software for pseudonymization and localization, protection against power failures and defects of the equipment, centralized and sustainable storage, easy localization and return of samples, and their destruction or anonymization after completion of an individual project. In addition to this important pure storage function, central biobanking can provide a link to clinical data as well as the anonymous use of samples for project-independent research. Both biobank functions serve different purposes, are associated with specific requirements, and should be pursued in parallel. If successful, central biomaterial management can achieve a sustainable improvement of academic and non-academic biomedical research and the optimal use of resources. The close collaboration between clinicians and non-clinicians is a crucial prerequisite for this.

[Registration of observational studies: it is time to comply with the Declaration of Helsinki requirement].

PubMed

Dal-Ré, Rafael; Delgado, Miguel; Bolumar, Francisco

2015-01-01

Publication bias is a serious deficiency in the current system of disseminating the results of human research studies. Clinical investigators know that, from an ethical standpoint, they should prospectively register clinical trials in a public registry before starting them. In addition, it is believed that this approach will help to reduce publication bias. However, most studies conducted in humans are observational rather than experimental. It is estimated that less than 2% out of 2 million concluded or ongoing observational studies have been registered. The 2013 revision of the Declaration of Helsinki requires registration of any type of research study involving humans or identifiable samples or data. It is proposed that funding agencies, such as the Fondo de Investigaciones Sanitarias, as well as private companies, require preregistration of observational studies before providing funding. It is also proposed that Research Ethics Committees which, following Spanish regulation, have been using the Declaration as the framework for assessing the ethics of clinical trials with medicines since 1990, should follow the same provisions for the assessment of health-related observational studies: therefore, they should require prospective registration of studies before granting their final approval. This would allow observational study investigators to be educated in complying with an ethical requirement recently introduced in the most important ethical code for research involving humans. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

Recommendations concerning the new U.S. National Institutes of Health initiative to balance the sex of cells and animals in preclinical research.

PubMed

Sandberg, Kathryn; Umans, Jason G

2015-05-01

The U.S. National Institutes of Health (NIH) announced last May that steps will be taken to address the over-reliance on male cells and animals in preclinical research. To further address this announcement, in September 2014, scientists with varying perspectives came together at Georgetown University to discuss the following questions. (1) What metrics should the NIH use to assess tangible progress on policy changes designed to address the over-reliance on male cells and animals in preclinical research? (2) How effective can education be in reducing the over-reliance on male cells and animals in preclinical research and what educational initiatives sponsored by the NIH would most likely effect change? (3) What criteria should the NIH use to determine rigorously defined exceptions to the future proposal requirement of a balance of male and female cells and animals in preclinical studies? (4) What additional strategies in addition to proposal requirements should NIH use to reduce the overreliance of male cells and animals in preclinical research? The resulting consensus presented herein includes input from researchers not only from diverse disciplines of basic and translational science including biology, cell and molecular biology, biochemistry, physiology, pharmacology, neuroscience, cardiology, endocrinology, nephrology, psychiatry, and obstetrics and gynecology, but also from recognized experts in publishing, industry, advocacy, science policy, clinical medicine, and population health. We offer our recommendations to aid the NIH as it selects, implements, monitors, and optimizes strategies to correct the over-reliance on male cells and animals in preclinical research. © FASEB.

The Addition of Several Mineral Sources on Growing Media of Fluorescent Pseudomonad for the Biosynthesis of Hydrogen Cyanide

NASA Astrophysics Data System (ADS)

Advinda, L.; Fifendy, M.; Anhar, A.

2018-04-01

All Fluorescent pseudomonad is a group of rhyzobacteria which these days often utilized on plant disease control. The growing media is an absolute requirement which needs to be considered for the growth and cultivation of bacteria. The mineral source contained in growing media of bacteria may affect the production of hydrogen cyanide compound. The objectives of the research were to obtain the best source of minerals for biosynthesis of cyanide acid compounds by fluorescent pseudomonad isolates PfPj1, PfPb1, PfPj2, Kd7, Cas, Cas3, and LAHp2. This research is a qualitative experimental research including observation of hydrogen cyanide compound produced after the growing media of fluorescent pseudomonad bacteria added with several mineral sources. The treatments were given: A = ZnSO4.7H2O 0.5 mM addition, B = CoCl2.6H2O 0.5 mM addition, and C = Fe2SO4.7H2O 0.5 mM addition. From the result of the research, it was concluded that the addition of ZnSO4.7H2O mineral resources on the growing media of fluorescent pseudomonad isolate Cas and Cas3 produced the best hydrogen cyanide. Whereas addition of CoCl2.6H2O mineral source on the growing media showed poor hydrogen cyanide production for all fluorescent pseudomonad isolates

Building research capacity with members of underserved American Indian/Alaskan Native communities: training in research ethics and the protection of human subjects.

PubMed

Jetter, Karen M; Yarborough, Mark; Cassady, Diana L; Styne, Dennis M

2015-05-01

To develop a research ethics training course for American Indian/Alaskan Native health clinic staff and community researchers who would be conducting human subjects research. Community-based participatory research methods were used in facilitated discussions of research ethics centered around topics included in the Collaborative Institutional Training Initiative research ethics course. The community-based participatory research approach allowed all partners to jointly develop a research ethics training program that was relevant for American Indian/Alaskan Native communities. All community and clinic partners were able to pass the Collaborative Institutional Training Initiative course they were required to pass so that they could be certified to conduct research with human subjects on federally funded projects. In addition, the training sessions provided a foundation for increased community oversight of research. By using a collaborative process to engage community partners in research ethics discussions, rather than either an asynchronous online or a lecture/presentation format, resulted in significant mutual learning about research ethics and community concerns about research. This approach requires university researchers to invest time in learning about the communities in which they will be working prior to the training. © 2014 Society for Public Health Education.

Communication/Placement Research Project: Communication Needs for Employment.

ERIC Educational Resources Information Center

Feinberg, Lilian O.

This report, undertaken to secure data to facilitate employment of Iowa State University graduates, summarizes information gathered from visits to 30 businesses and corporations in Iowa and Illinois. Comments address the following aspects of application and employment: additional studies required, general and communication skills, style of…

The President’s Budget: Overview of Structure and Timing of Submission to Congress

DTIC Science & Technology

2013-07-25

Nuclear Facilities Safety Board, Securities and Exchange Commission, and National Transportation Safety Board) are required by statute to submit...Research Service 4 Governors of the Federal Reserve System, and Federal National Mortgage Association).22 Additionally, certain agencies (e.g., Defense

Importance of Labor in Adoption of a Modern Farm Input.

ERIC Educational Resources Information Center

Ndiaye, Serigne; Sofranko, Andrew J.

1988-01-01

Explores relationship between farm technology and labor availability in Africa. Studies introduction of high-yielding maize variety in Zambia and resulting effects on labor availability/mobilization. Shows shift to hybrids requires additional labor, including available children. Illustrates need for adoption research taking broader farming…

Marihuana in Man: Three Years Later

ERIC Educational Resources Information Center

Hollister, Leo E.

1971-01-01

Reviews three years of research on the effects of marihuana in man. Previously known clinical mental and physical effects have been confirmed. Causes and mechanisms of these effects generally remain undetermined in man and animals. Social implications and long term effects require additional study, although usage appears detrimental. (JM)

For Healthcare Professionals | Center for Cancer Research

Cancer.gov

How to Refer a Patient Our care team contacts any prospective patients within 24 business hours after your call to collect basic information and give further instructions. We require a medical summary, operative notes, relevant radiographic scans (MRI, CT, PET), pathology report, and additional materials as indicated.

R&D Jobs for BS Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1985-01-01

Outlines opportunities for beginning engineers seeking employment in research and development (R&D). R&D spending growth, underlying factors, job categories, and divisions within an industrial firm are discussed. Above average grades and additional mathematics courses are primary requirements for an R&D position, which may later lead to…

Grain Fumigation: A Multifaceted Issue Needing Coordinated Attention.

DTIC Science & Technology

1981-09-10

ground odors," but a re- searcher at the U.S. Department of Agriculture’s (TJSDA’s) Grain 2 6- -A& Marketing Research Laboratory in Manhattan, Kansas...Following are some additional issues which will have an impact in the future and require con- sideration and, perhaps, resolption. --USDA’s Grain Marketing ... Research Laboratory recently found that heavy infestations of damaging insects were threatening the quality and value of millions of bushels of

Management Knowledge and Skills Required in the Health Care System of the Federation Bosnia and Herzegovina

PubMed Central

Slipicevic, Osman; Masic, Izet

2012-01-01

Extremely complex health care organizations, by their structure and organization, operate in a constantly changing business environment, and such situation implies and requires complex and demanding health management. Therefore, in order to manage health organizations in a competent manner, health managers must possess various managerial skills and be familiar with problems in health care. Research, identification, analysis, and assessment of health management education and training needs are basic preconditions for the development and implementation of adequate programs to meet those needs. Along with other specific activities, this research helped to determine the nature, profile, and level of top-priority needs for education. The need for knowledge of certain areas in health management, as well as the need for mastering concrete managerial competencies has been recognized as top-priorities requiring additional improvement and upgrading. PMID:23922519

Developing a Science Commons for Geosciences

NASA Astrophysics Data System (ADS)

Lenhardt, W. C.; Lander, H.

2016-12-01

Many scientific communities, recognizing the research possibilities inherent in data sets, have created domain specific archives such as the Incorporated Research Institutions for Seismology (iris.edu) and ClinicalTrials.gov. Though this is an important step forward, most scientists, including geoscientists, also use a variety of software tools and at least some amount of computation to conduct their research. While the archives make it simpler for scientists to locate the required data, provisioning disk space, compute resources, and network bandwidth can still require significant efforts. This challenge exists despite the wealth of resources available to researchers, namely lab IT resources, institutional IT resources, national compute resources (XSEDE, OSG), private clouds, public clouds, and the development of cyberinfrastructure technologies meant to facilitate use of those resources. Further tasks include obtaining and installing required tools for analysis and visualization. If the research effort is a collaboration or involves certain types of data, then the partners may well have additional non-scientific tasks such as securing the data and developing secure sharing methods for the data. These requirements motivate our investigations into the "Science Commons". This paper will present a working definition of a science commons, compare and contrast examples of existing science commons, and describe a project based at RENCI to implement a science commons for risk analytics. We will then explore what a similar tool might look like for the geosciences.

Computational fluid dynamics research at the United Technologies Research Center requiring supercomputers

NASA Astrophysics Data System (ADS)

Landgrebe, Anton J.

1987-03-01

An overview of research activities at the United Technologies Research Center (UTRC) in the area of Computational Fluid Dynamics (CFD) is presented. The requirement and use of various levels of computers, including supercomputers, for the CFD activities is described. Examples of CFD directed toward applications to helicopters, turbomachinery, heat exchangers, and the National Aerospace Plane are included. Helicopter rotor codes for the prediction of rotor and fuselage flow fields and airloads were developed with emphasis on rotor wake modeling. Airflow and airload predictions and comparisons with experimental data are presented. Examples are presented of recent parabolized Navier-Stokes and full Navier-Stokes solutions for hypersonic shock-wave/boundary layer interaction, and hydrogen/air supersonic combustion. In addition, other examples of CFD efforts in turbomachinery Navier-Stokes methodology and separated flow modeling are presented. A brief discussion of the 3-tier scientific computing environment is also presented, in which the researcher has access to workstations, mid-size computers, and supercomputers.

Computational fluid dynamics research at the United Technologies Research Center requiring supercomputers

NASA Technical Reports Server (NTRS)

Landgrebe, Anton J.

1987-01-01

An overview of research activities at the United Technologies Research Center (UTRC) in the area of Computational Fluid Dynamics (CFD) is presented. The requirement and use of various levels of computers, including supercomputers, for the CFD activities is described. Examples of CFD directed toward applications to helicopters, turbomachinery, heat exchangers, and the National Aerospace Plane are included. Helicopter rotor codes for the prediction of rotor and fuselage flow fields and airloads were developed with emphasis on rotor wake modeling. Airflow and airload predictions and comparisons with experimental data are presented. Examples are presented of recent parabolized Navier-Stokes and full Navier-Stokes solutions for hypersonic shock-wave/boundary layer interaction, and hydrogen/air supersonic combustion. In addition, other examples of CFD efforts in turbomachinery Navier-Stokes methodology and separated flow modeling are presented. A brief discussion of the 3-tier scientific computing environment is also presented, in which the researcher has access to workstations, mid-size computers, and supercomputers.

A pocket guide to electronic laboratory notebooks in the academic life sciences

PubMed Central

Dirnagl, Ulrich; Przesdzing, Ingo

2016-01-01

Every professional doing active research in the life sciences is required to keep a laboratory notebook. However, while science has changed dramatically over the last centuries, laboratory notebooks have remained essentially unchanged since pre-modern science. We argue that the implementation of electronic laboratory notebooks (eLN) in academic research is overdue, and we provide researchers and their institutions with the background and practical knowledge to select and initiate the implementation of an eLN in their laboratories. In addition, we present data from surveying biomedical researchers and technicians regarding which hypothetical features and functionalities they hope to see implemented in an eLN, and which ones they regard as less important. We also present data on acceptance and satisfaction of those who have recently switched from paper laboratory notebook to an eLN.  We thus provide answers to the following questions: What does an electronic laboratory notebook afford a biomedical researcher, what does it require, and how should one go about implementing it? PMID:26835004

Satellite Power Systems (SPS) concept definition study. Volume 6: SPS technology requirements and verification

NASA Technical Reports Server (NTRS)

Hanley, G.

1978-01-01

Volume 6 of the SPS Concept Definition Study is presented and also incorporates results of NASA/MSFC in-house effort. This volume includes a supporting research and technology summary. Other volumes of the final report that provide additional detail are as follows: (1) Executive Summary; (2) SPS System Requirements; (3) SPS Concept Evolution; (4) SPS Point Design Definition; (5) Transportation and Operations Analysis; and Volume 7, SPS Program Plan and Economic Analysis.

Usage of information safety requirements in improving tube bending process

NASA Astrophysics Data System (ADS)

Livshitz, I. I.; Kunakov, E.; Lontsikh, P. A.

2018-05-01

This article is devoted to an improvement of the technological process's analysis with the information security requirements implementation. The aim of this research is the competition increase analysis in aircraft industry enterprises due to the information technology implementation by the example of the tube bending technological process. The article analyzes tube bending kinds and current technique. In addition, a potential risks analysis in a tube bending technological process is carried out in terms of information security.

Work Program. Fiscal Year 1969 for The Department of the Army. Research and Development in Training, Motivation, and Leadership

DTIC Science & Technology

1969-01-01

job requiremeits in these skills , and (2) developing technique.; for improving literacy skills through training. In addition, manpower pools for a given...job requirements in these skills , and (2) developing techniques for improving literacy skills through training. In addition, manpower pools for a...visual and psychomotor skills -for accurate .nd’efficient operation, and performance variations among gunners are the largest source of error in system

From path models to commands during additive printing of large-scale architectural designs

NASA Astrophysics Data System (ADS)

Chepchurov, M. S.; Zhukov, E. M.; Yakovlev, E. A.; Matveykin, V. G.

2018-05-01

The article considers the problem of automation of the formation of large complex parts, products and structures, especially for unique or small-batch objects produced by a method of additive technology [1]. Results of scientific research in search for the optimal design of a robotic complex, its modes of operation (work), structure of its control helped to impose the technical requirements on the technological process for manufacturing and design installation of the robotic complex. Research on virtual models of the robotic complexes allowed defining the main directions of design improvements and the main goal (purpose) of testing of the the manufactured prototype: checking the positioning accuracy of the working part.

An interdisciplinary learning experience in neuro-optics.

PubMed

Anselmi, Francesca; Bertherat, Julien; Estebanez, Luc; van 't Hoff, Marcel; Zylbersztejn, Kathleen

2012-01-01

How can a Ph.D. student initially trained as a biologist take part in the development of a multineuronal recording method that requires cross interaction between physics, neurobiology and mathematics? Beyond student training in the laboratory, interdisciplinary research calls for a new style of academic training of young researchers. Here we present an innovative approach to graduate student academic training that fills the need for multidisciplinary knowledge and provides students, in addition, with a deeper understanding of the interdisciplinary approach to scientific research. Copyright © 2012 Elsevier Ltd. All rights reserved.

Cytochrome P450 2C9 gene polymorphism and warfarin maintenance dosage in pediatric patients: A systematic review and meta-analysis.

PubMed

Zhang, Jinhua; Tian, Lihong; Huang, Jinlong; Huang, Sihan; Chai, Tingting; Shen, Jianzhen

2017-02-01

To assess the effect of Cytochrome P450 2C9 (CYP2C9) gene polymorphism on pediatric warfarin maintenance dosage requirement. A previously developed search strategy was conducted in PubMed, EMBASE, and the Cochrane Library. Eligible studies published prior to January 27, 2016, were identified and compared against strict inclusion/exclusion criteria. Required data were extracted, and researchers were consulted for additional data if needed. Review Manager version 5.2.3 software was used to analyze the relationship between CYP2C9 polymorphisms and warfarin maintenance doses in pediatric patients. Eight articles with a combined total of 507 pediatric patients were included in the meta-analysis. Maintenance warfarin doses in patients with CYP2C9 *1/*2 genotype, CYP2C9 *1/*3 genotype, and CYP2C9 variant carriers which contain at least one variant allele (*2 or *3) were from 15% to 41% lower than doses in patients with the wild-type allele (CYP2C9 *1/*1): All differences were significant with P-values <.05. The Fontan procedure as a medical indication for anticoagulation was also associated with a lower warfarin maintenance dose; however, target INR range was not. We found that CYP2C9 gene polymorphism (referring to the presence of *1/*2, *1/*3, and variant genotypes in the population in addition to the wild type) was significantly associated with decreased warfarin maintenance dose requirements. Additionally, a specific indication for warfarin, the Fontan procedure, was associated with a lower daily warfarin dose. However, the results of our study require confirmation from more research with larger numbers of pediatric patients. © 2016 John Wiley & Sons Ltd.

The development of a relevant and comprehensive research agenda to improve Hispanic health.

PubMed Central

Marin, G; Amaro, H; Eisenberg, C; Opava-Stitzer, S

1993-01-01

The development of an appropriate research agenda for Hispanics requires progress in three areas: (a) developing an appropriate research infrastructure, (b) increasing the availability of appropriate research instrumentation, and (c) identifying and assigning priority areas. In addition, a Latino health research agenda must identify mechanisms for increasing the number of trained Hispanic researchers and the number of Latino professional staff members at the Department of Health and Human Services. It is recommended that an Office of Hispanic Health be established within the Office of Minority Health at the Department to oversee the implementation of the recommendations made as part of the Surgeon General's National Hispanic Health Initiative. PMID:8416112

A Hybrid EAV-Relational Model for Consistent and Scalable Capture of Clinical Research Data.

PubMed

Khan, Omar; Lim Choi Keung, Sarah N; Zhao, Lei; Arvanitis, Theodoros N

2014-01-01

Many clinical research databases are built for specific purposes and their design is often guided by the requirements of their particular setting. Not only does this lead to issues of interoperability and reusability between research groups in the wider community but, within the project itself, changes and additions to the system could be implemented using an ad hoc approach, which may make the system difficult to maintain and even more difficult to share. In this paper, we outline a hybrid Entity-Attribute-Value and relational model approach for modelling data, in light of frequently changing requirements, which enables the back-end database schema to remain static, improving the extensibility and scalability of an application. The model also facilitates data reuse. The methods used build on the modular architecture previously introduced in the CURe project.

Prevention of Dating Violence on College Campuses: An Innovative Program

ERIC Educational Resources Information Center

Schwartz, Jonathan P.; Griffin, Linda D.; Russell, Melani M.; Frontaura-Duck, Sarannette

2006-01-01

Dating violence is a significant problem on college campuses that requires preventive interventions. In addition, sexist and stereotypical attitudes that support abusive dating behavior have been recognized as potential risk factors. Previous research has found that fraternity and sorority membership is related to stereotypical beliefs concerning…

Value of Family and Group Counseling Models where Grandparents Function as Parents to Their Grandchildren

ERIC Educational Resources Information Center

Edwards, Oliver W.; Ray, Shannon L.

2010-01-01

Those involved in circumstances in which children are raised by their grandparents often encounter serious problems that require assistance from counselors. Research suggests that grandparents and parents in these families typically experience heightened stress and psychosocial distress. Additionally, the children often encounter behavioral,…

AMPS Supporting Research and Technology (SR and T) report. Atmospheric, Magnetospheric and Plasmas in Space (AMPS) definition study

NASA Technical Reports Server (NTRS)

1976-01-01

A listing of candidate technology areas that require additional study is presented. These candidate tasks, identified during the AMPS Phase B studies, are requisites to the design, development, and operation of the AMPS concept selected for preliminary design.

A Meta-Analysis of Individualized Instruction in Dental Education.

ERIC Educational Resources Information Center

Dacanay, Lakshmi S; Cohen, Peter A.

1992-01-01

Meta-analysis of 34 comparative studies on conventional vs. individualized instruction (II) found most favored the latter but with small-moderate overall effect. Pacing had significant effect, with teacher-pacing more effective than student-paced learning. On average, II required less time than conventional teaching. Additional research on this…

Models for Conducting Institutional Research. New Directions for Community Colleges, Number 72.

ERIC Educational Resources Information Center

MacDougall, Peter, Ed.; Friedlander, Jack, Ed.

1990-01-01

Recent mandates from state and accrediting agencies are requiring community colleges to provide evidence of their success in such areas as basic skills and remediation, general education, major-field content, student development, transfer effectiveness, job training, job placement, and fiscal accountability. This volume, in addition to describing…

40 CFR 26.1101 - To what does this subpart apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving... after April 15, 2013 involving intentional exposure of a human subject to: (1) Any substance if, at any... regulations which provide additional protections for human subjects. (f) This subpart does not affect any...

40 CFR 26.1101 - To what does this subpart apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving... initiated after April 7, 2006 involving intentional exposure of a human subject if, at any time prior to... additional protections for human subjects. (e) This subpart does not affect any State or local laws or...

40 CFR 26.1101 - To what does this subpart apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving... after April 15, 2013 involving intentional exposure of a human subject to: (1) Any substance if, at any... regulations which provide additional protections for human subjects. (f) This subpart does not affect any...

40 CFR 26.1101 - To what does this subpart apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides Involving... initiated after April 7, 2006 involving intentional exposure of a human subject if, at any time prior to... additional protections for human subjects. (e) This subpart does not affect any State or local laws or...

Reimagining Indian Higher Education: A Social Ecology of Higher Higher-Education Institutions

ERIC Educational Resources Information Center

Tierney, William G.; Sabharwal, Nidhi S.

2018-01-01

Background/Context: Developing countries desire institutions ranked as "world-class," and want to increase postsecondary participation. Limited public monies require decisions that usually augment the welfare of one objective at the expense of another. An additional conundrum concerns the need for quality assurances. Research needs to be…

BRD4 Regulates Transcription via Intrinsic HAT Activity | Center for Cancer Research

Cancer.gov

In order to express a gene, its DNA must be accessible to the transcription machinery. This requires chromatin de-compaction, which depends on the addition of acetyl groups to lysine residues on histones, thereby weakening interactions between histones and DNA and between adjacent nucleosomes.

76 FR 34063 - Procurement List; Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-10

.... Coast Guard. NSN: 8415-01-588-2047--Neckdam, Chemical, Protective, JPACE, CPC, JC3, Green. NPA: Peckham..., & Engineering Command, Natick, MA. Coverage: C-List for 100% of the requirement of the U.S. Army, as aggregated by the Department of the Army Research, Development, & Engineering Command, Natick, MA. Self-stick...

Media Specialists Can Learn Web 2.0 Tools to Make Schools More Cool

ERIC Educational Resources Information Center

Hauser, Judy

2007-01-01

Media specialists today are required to use more and more technology. Their responsibilities encompass everything from repairing overhead projectors to administrating an entire library's automated system. These responsibilities are in addition to working with students on research and information literacy, making book selections, and collaborating…

Teacher Perceptions of the Effectiveness of the Response to Intervention (RTI) Process

ERIC Educational Resources Information Center

Anderson, Yarby

2017-01-01

With federal education mandates and new developments highlighting academic failures, additional stress has been placed on teachers and administrators to provide interventions to a student's specific deficit areas. Now, general education teachers are required to use research-based interventions to eliminate the decline in academic success. The…

New law requires 'medically accurate' lesson plans.

PubMed

1999-09-17

The California Legislature has passed a bill requiring all textbooks and materials used to teach about AIDS be medically accurate and objective. Statements made within the curriculum must be supported by research conducted in compliance with scientific methods, and published in peer-reviewed journals. Some of the current lesson plans were found to contain scientifically unsupported and biased information. In addition, the bill requires material to be "free of racial, ethnic, or gender biases." The legislation is supported by a wide range of interests, but opposed by the California Right to Life Education Fund, because they believe it discredits abstinence-only material.

The impact of regulations, safety considerations and physical limitations on research progress at maximum biocontainment.

PubMed

Shurtleff, Amy C; Garza, Nicole; Lackemeyer, Matthew; Carrion, Ricardo; Griffiths, Anthony; Patterson, Jean; Edwin, Samuel S; Bavari, Sina

2012-12-01

We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations and size of research projects investigating microbial pathogens of biodefense concern. Acquisition, use, storage, and transfer of biological select agents and toxins (BSAT) are highly regulated due to their potential to pose a severe threat to public health and safety. All federal, state, city, and local regulations must be followed to obtain and maintain registration for the institution to conduct research involving BSAT. These include initial screening and continuous monitoring of personnel, controlled access to containment laboratories, accurate and current BSAT inventory records. Safety considerations are paramount in BSL-4 containment laboratories while considering the types of research tools, workflow and time required for conducting both in vivo and in vitro experiments in limited space. Required use of a positive-pressure encapsulating suit imposes tremendous physical limitations on the researcher. Successful mitigation of these constraints requires additional time, effort, good communication, and creative solutions. Test and evaluation of novel vaccines and therapeutics conducted under good laboratory practice (GLP) conditions for FDA approval are prioritized and frequently share the same physical space with important ongoing basic research studies. The possibilities and limitations of biomedical research involving microbial pathogens of biodefense concern in BSL-4 containment laboratories are explored in this review.

The Impact of Regulations, Safety Considerations and Physical Limitations on Research Progress at Maximum Biocontainment

PubMed Central

Shurtleff, Amy C.; Garza, Nicole; Lackemeyer, Matthew; Carrion, Ricardo; Griffiths, Anthony; Patterson, Jean; Edwin, Samuel S.; Bavari, Sina

2012-01-01

We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. These limitations can severely impact the number of collaborations and size of research projects investigating microbial pathogens of biodefense concern. Acquisition, use, storage, and transfer of biological select agents and toxins (BSAT) are highly regulated due to their potential to pose a severe threat to public health and safety. All federal, state, city, and local regulations must be followed to obtain and maintain registration for the institution to conduct research involving BSAT. These include initial screening and continuous monitoring of personnel, controlled access to containment laboratories, accurate and current BSAT inventory records. Safety considerations are paramount in BSL-4 containment laboratories while considering the types of research tools, workflow and time required for conducting both in vivo and in vitro experiments in limited space. Required use of a positive-pressure encapsulating suit imposes tremendous physical limitations on the researcher. Successful mitigation of these constraints requires additional time, effort, good communication, and creative solutions. Test and evaluation of novel vaccines and therapeutics conducted under good laboratory practice (GLP) conditions for FDA approval are prioritized and frequently share the same physical space with important ongoing basic research studies. The possibilities and limitations of biomedical research involving microbial pathogens of biodefense concern in BSL-4 containment laboratories are explored in this review. PMID:23342380

Successes and challenges in a novel doctoral program in systems agriculture: a case example.

PubMed

Lust, D; Topliff, D; Deotte, R

2010-01-01

A doctoral program in Systems Agriculture was initiated at West Texas A&M University, Canyon, TX, in September, 2003. The stated objective of the program was "..to prepare leaders for the agricultural industry that are trained in a multidisciplinary, research-based curriculum that emphasizes a systems approach to problem solving". The program offers a single doctoral degree in Agriculture and accepts qualified students with a master's or professional degree in agricultural or related disciplines. Courses related to systems methodologies, leadership, agricultural economics, plant and soil science, and animal science are required. Additional program requirements include a systems research project and dissertation, leadership training, and written and oral exams. The program has exceeded enrollment and graduation targets, suggesting interest in this approach to a doctoral degree. Students have entered the program with M.S. backgrounds in education, traditional agricultural disciplines, veterinary medicine, business, and physics. Graduates have gained employment in industry, university teaching and research, government research/administration, and extension. Doctoral student projects in systems agriculture contributed to curriculum changes and to the conceptual framework adopted by a multi-state research group. Designing and teaching courses for students with diverse backgrounds has been challenging. Development of a common understanding of systems agriculture was identified by a third-party program review as an issue for faculty. Development and maintenance of program standards and administrative procedures posed additional challenges. Leadership, administrative support, and timely and continuing program assessment are suggested as necessary components for a nontraditional doctoral program.

DMPTool: New Guidance, Resources, and Outreach for Quality Data Management Plans

NASA Astrophysics Data System (ADS)

Cruse, P.; Sallans, A.

2013-12-01

A growing number of US federal funding agencies require data management plans (DMP) as part of new research grant proposals. To help researchers with this requirement, several organizations (the California Digital Library, University of Illinois, University of Virginia, Smithsonian Institution, the DataONE consortium and the (UK) Digital Curation Centre) came together to develop the DMPTool in 2011. The goal of the DMPTool is to provide researchers with guidance, links to resources and help with writing data management plans. Thanks to a grant from the Alfred P. Sloan Foundation, these organizations have been able to develop DMPTool2, adding new features and functionality, while aiming to grow the number of users and funding requirements and build a community around DMP best practices. Researchers create plans in the tool by selecting their desired funding agency. The tool provides specific requirements from the selected agency as well as detailed help with each area of the plan. Users have access to complete DMP life cycle management, tracking changes through creation, editing, submission, evaluation, and publication. They may also perform enhanced keyword searches and view publicly available plans. With role-based user authorization, users may hold various roles within the interface: creators, collaborators, institutional administrators, and tool administrators. Furthermore, partner institutions can add significant value to the process with several special tool features. Along with institutional branding in the interface, they can provide links to resources they provide to users, such as to preservation repositories, consultation services, or news and event items. In addition, partner institutions can provide help with specific plan questions, and even suggest responses. Institutional administrators can also mine data on plans in order to better support researchers. Institutions may be represented in different roles: as a funder, a researcher's affiliate, or as an institution with its own DMP requirements.

Xenon Purification Research and Development for the LZ Dark Matter Experiment

NASA Astrophysics Data System (ADS)

Pech, Katherin

2013-04-01

The LZ Experiment is a next generation dark matter detector based on the current LUX detector design, with a 7-ton active volume. Although many research and development breakthroughs were achieved for the 350 kg LUX detector, the large volume scaling required for LZ presents a new set of design challenges that need to be overcome. Because the search for WIMP-like dark matter requires ultra low background experiments, the xenon target material in the LZ detector must meet purity specifications beyond what is commercially available. This challenge is two-fold. The xenon must contain extremely low amounts of electronegative impurities such as oxygen, which attenuate the charge signal. Additionally, it must also have very little of the inert isotope Kr-85, a beta-emitter that can obscure the dark matter signal in the detector volume. The purity requirements for the LUX experiment have been achieved, but the factor of 20 scaling in volume for LZ and increased demands for sensitivity mean that new research and development work must be done to increase our xenon purification capabilities. This talk will focus on the efforts being done at Case Western Reserve University to meet these strict purity requirements for the LZ Experiment.

Report on Quality Control Review of the Raich Ende Malter & Co. LLP FY 2009 Single Audit of the Riverside Research Institute

DTIC Science & Technology

2012-03-07

compliance was based on a determination that 10 of the 14 compliance requirements were applicable to the Institute. However, the audit working papers...for all 14 of the compliance requirements were not adequate to support conclusions on applicability, internal control, and the audit opinion on...compliance with laws, regulations, and award provisions applicable to the R&D cluster program. In addition, the audit firm did not appropriately report an

Bone regeneration and stem cells

PubMed Central

Arvidson, K; Abdallah, B M; Applegate, L A; Baldini, N; Cenni, E; Gomez-Barrena, E; Granchi, D; Kassem, M; Konttinen, Y T; Mustafa, K; Pioletti, D P; Sillat, T; Finne-Wistrand, A

2011-01-01

Abstract This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, effects of sex steroids on mesenchymal stem cells, use of platelet-rich plasma for tissue repair, osteogenesis and its molecular markers. A variety of cells in addition to stem cells, as well as advances in materials science to meet specific requirements for bone and soft tissue regeneration by addition of bioactive molecules, are discussed. PMID:21129153

Flat-plate solar array project. Volume 6: Engineering sciences and reliability

NASA Technical Reports Server (NTRS)

Ross, R. G., Jr.; Smokler, M. I.

1986-01-01

The Flat-Plate Solar Array (FSA) Project activities directed at developing the engineering technology base required to achieve modules that meet the functional, safety, and reliability requirements of large scale terrestrial photovoltaic systems applications are reported. These activities included: (1) development of functional, safety, and reliability requirements for such applications; (2) development of the engineering analytical approaches, test techniques, and design solutions required to meet the requirements; (3) synthesis and procurement of candidate designs for test and evaluation; and (4) performance of extensive testing, evaluation, and failure analysis of define design shortfalls and, thus, areas requiring additional research and development. A summary of the approach and technical outcome of these activities are provided along with a complete bibliography of the published documentation covering the detailed accomplishments and technologies developed.

A Call to Standardize Preanalytic Data Elements for Biospecimens, Part II.

PubMed

Robb, James A; Bry, Lynn; Sluss, Patrick M; Wagar, Elizabeth A; Kennedy, Mary F

2015-09-01

Biospecimens must have appropriate clinical annotation (data) to ensure optimal quality for both patient care and research. Additional clinical preanalytic variables are the focus of this continuing study. To complete the identification of the essential preanalytic variables (data fields) that can, and in some instances should, be attached to every collected biospecimen by adding the additional specific variables for clinical chemistry and microbiology to our original 170 variables. The College of American Pathologists Diagnostic Intelligence and Health Information Technology Committee sponsored a second Biorepository Working Group to complete the list of preanalytic variables for annotating biospecimens. Members of the second Biorepository Working Group are experts in clinical pathology and microbiology. Additional preanalytic area-specific variables were identified and ranked along with definitions and potential negative impacts if the variable is not attached to the biospecimen. The draft manuscript was reviewed by additional national and international stakeholders. Four additional required preanalytic variables were identified specifically for clinical chemistry and microbiology biospecimens that can be used as a guide for site-specific implementation into patient care and research biorepository processes. In our collective experience, selecting which of the many preanalytic variables to attach to any specific set of biospecimens used for patient care and/or research is often difficult. The additional ranked list should be of practical benefit when selecting preanalytic variables for a given biospecimen collection.

The role of pediatricians as innovators in pediatric nutrition.

PubMed

Greer, Frank R

2010-01-01

Innovation is about making changes. When it comes to health care, innovations, though they may be something 'new', may not be beneficial if not demonstrated to be an improvement over what is current practice. Innovations in pediatric nutrition sometimes fall into this category. The establishment of safe water and milk supplies at the end of the 19th and beginning of the 20th centuries is viewed as one of the greatest advances in preventative medicine and truly was an 'innovation', with its dramatic impact on infant mortality. Other innovations in pediatric nutrition included the development of the caloric method of infant feeding which led to the large-scale adoption of a single infant formula. This required cooperation with industry and ultimately led to the development of life-saving specialty formulas for various disease states including inborn errors of metabolism. Over the last 50 years there have been further modifications of term infant formula that have included taurine, carnitine, nucleotides, whey proteins, PUFAs including decosahexenoic acid (DHA) and arachidonic acid, probiotics, and prebiotics. Many of these additions are of questionable benefit and are questioned as true innovations. Though the addition of novel nutrients to infant formula has been an area of great interest, more basic research (including randomized controlled trial) is needed to determine many pediatric nutrient requirements including the lower and upper limits of nutrients added to infant formula. Such research could be facilitated by institutions such as the US National Institute of Child Health whose establishment in 1962 was a significant 'innovation' as it led to advances in pediatric nutritional research. Much more research is needed to determine basic pediatric nutritional requirements and pediatricians should strive for such true innovations. Copyright © 2010 S. Karger AG, Basel.

Research priorities and plans for the International Space Station-results of the 'REMAP' Task Force

NASA Technical Reports Server (NTRS)

Kicza, M.; Erickson, K.; Trinh, E.

2003-01-01

Recent events in the International Space Station (ISS) Program have resulted in the necessity to re-examine the research priorities and research plans for future years. Due to both technical and fiscal resource constraints expected on the International Space Station, it is imperative that research priorities be carefully reviewed and clearly articulated. In consultation with OSTP and the Office of Management and budget (OMB), NASA's Office of Biological and Physical Research (OBPR) assembled an ad-hoc external advisory committee, the Biological and Physical Research Maximization and Prioritization (REMAP) Task Force. This paper describes the outcome of the Task Force and how it is being used to define a roadmap for near and long-term Biological and Physical Research objectives that supports NASA's Vision and Mission. Additionally, the paper discusses further prioritizations that were necessitated by budget and ISS resource constraints in order to maximize utilization of the International Space Station. Finally, a process has been developed to integrate the requirements for this prioritized research with other agency requirements to develop an integrated ISS assembly and utilization plan that maximizes scientific output. c2003 American Institute of Aeronautics and Astronautics. Published by Elsevier Science Ltd. All rights reserved.

Applied Operations Research: Operator's Assistant

NASA Technical Reports Server (NTRS)

Cole, Stuart K.

2015-01-01

NASA operates high value critical equipment (HVCE) that requires trouble shooting, periodic maintenance and continued monitoring by Operations staff. The complexity HVCE and information required to maintain and trouble shoot HVCE to assure continued mission success as paper is voluminous. Training on new HVCE is commensurate with the need for equipment maintenance. LaRC Research Directorate has undertaken a proactive research to support Operations staff by initiation of the development and prototyping an electronic computer based portable maintenance aid (Operator's Assistant). This research established a goal with multiple objectives and a working prototype was developed. The research identified affordable solutions; constraints; demonstrated use of commercial off the shelf software; use of the US Coast Guard maintenance solution; NASA Procedure Representation Language; and the identification of computer system strategies; where these demonstrations and capabilities support the Operator, and maintenance. The results revealed validation against measures of effectiveness and overall proved a substantial training and capability sustainment tool. The research indicated that the OA could be deployed operationally at the LaRC Compressor Station with an expectation of satisfactorily results and to obtain additional lessons learned prior to deployment at other LaRC Research Directorate Facilities. The research revealed projected cost and time savings.

Unique Testing Capabilities of the NASA Langley Transonic Dynamics Tunnel, an Exercise in Aeroelastic Scaling

NASA Technical Reports Server (NTRS)

Ivanco, Thomas G.

2013-01-01

NASA Langley Research Center's Transonic Dynamics Tunnel (TDT) is the world's most capable aeroelastic test facility. Its large size, transonic speed range, variable pressure capability, and use of either air or R-134a heavy gas as a test medium enable unparalleled manipulation of flow-dependent scaling quantities. Matching these scaling quantities enables dynamic similitude of a full-scale vehicle with a sub-scale model, a requirement for proper characterization of any dynamic phenomenon, and many static elastic phenomena. Select scaling parameters are presented in order to quantify the scaling advantages of TDT and the consequence of testing in other facilities. In addition to dynamic testing, the TDT is uniquely well-suited for high risk testing or for those tests that require unusual model mount or support systems. Examples of recently conducted dynamic tests requiring unusual model support are presented. In addition to its unique dynamic test capabilities, the TDT is also evaluated in its capability to conduct aerodynamic performance tests as a result of its flow quality. Results of flow quality studies and a comparison to a many other transonic facilities are presented. Finally, the ability of the TDT to support future NASA research thrusts and likely vehicle designs is discussed.

Lewis Information Network (LINK): Background and overview

NASA Technical Reports Server (NTRS)

Schulte, Roger R.

1987-01-01

The NASA Lewis Research Center supports many research facilities with many isolated buildings, including wind tunnels, test cells, and research laboratories. These facilities are all located on a 350 acre campus adjacent to the Cleveland Hopkins Airport. The function of NASA-Lewis is to do basic and applied research in all areas of aeronautics, fluid mechanics, materials and structures, space propulsion, and energy systems. These functions require a great variety of remote high speed, high volume data communications for computing and interactive graphic capabilities. In addition, new requirements for local distribution of intercenter video teleconferencing and data communications via satellite have developed. To address these and future communications requirements for the next 15 yrs, a project team was organized to design and implement a new high speed communication system that would handle both data and video information in a common lab-wide Local Area Network. The project team selected cable television broadband coaxial cable technology as the communications medium and first installation of in-ground cable began in the summer of 1980. The Lewis Information Network (LINK) became operational in August 1982 and has become the backbone of all data communications and video.

Utilization of coal fly ash in solidification of liquid radioactive waste from research reactor.

PubMed

Osmanlioglu, Ahmet Erdal

2014-05-01

In this study, the potential utilization of fly ash was investigated as an additive in solidification process of radioactive waste sludge from research reactor. Coal formations include various percentages of natural radioactive elements; therefore, coal fly ash includes various levels of radioactivity. For this reason, fly ashes have to be evaluated for potential environmental implications in case of further usage in any construction material. But for use in solidification of radioactive sludge, the radiological effects of fly ash are in the range of radioactive waste management limits. The results show that fly ash has a strong fixing capacity for radioactive isotopes. Specimens with addition of 5-15% fly ash to concrete was observed to be sufficient to achieve the target compressive strength of 20 MPa required for near-surface disposal. An optimum mixture comprising 15% fly ash, 35% cement, and 50% radioactive waste sludge could provide the solidification required for long-term storage and disposal. The codisposal of radioactive fly ash with radioactive sludge by solidification decreases the usage of cement in solidification process. By this method, radioactive fly ash can become a valuable additive instead of industrial waste. This study supports the utilization of fly ash in industry and the solidification of radioactive waste in the nuclear industry.

The International Space Station Habitat

NASA Technical Reports Server (NTRS)

Watson, Patricia Mendoza; Engle, Mike

2003-01-01

The International Space Station (ISS) is an engineering project unlike any other. The vehicle is inhabited and operational as construction goes on. The habitability resources available to the crew are the crew sleep quarters, the galley, the waste and hygiene compartment, and exercise equipment. These items are mainly in the Russian Service Module and their placement is awkward for the crew to deal with ISS assembly will continue with the truss build and the addition of International Partner Laboratories. Also, Node 2 and 3 will be added. The Node 2 module will provide additional stowage volume and room for more crew sleep quarters. The Node 3 module will provide additional Environmental Control and Life Support Capability. The purpose of the ISS is to perform research and a major area of emphasis is the effects of long duration space flight on humans, a result of this research they will determine what are the habitability requirements for long duration space flight.

Fostering research aptitude among high school students through space weather competition

NASA Astrophysics Data System (ADS)

Abdullah, M.; Majid, R. A.; Bais, B.; Bahri, N. S.; Asillam, M. F.

2018-01-01

Cultivating research culture at an early stage is important for capacity building in a community. The high school level is the appropriate stage for research to be introduced because of students' competitive nature. Participation in the space weather competition is one of the ways in which research aptitude can be fostered in high school students in Malaysia. Accordingly, this paper presents how research elements were introduced to the students at the high school level through their participation in the space weather competition. The competition required the students to build a system to detect the presence of solar flares by utilizing VLF signals reflected from the ionosphere. The space weather competition started off with proposal writing for the space weather related project where the students were required to execute extensive literature review on the given topic. Additionally, the students were also required to conduct the experiments and analyse the data. Results obtained from data analysis were then validated by the students through various other observations that they had to carry out. At the end of the competition, students were expected to write a comprehensive technical report. Through this competition, the students learnt how to conduct research in accordance to the guidelines provided through the step by step approach exposed to them. Ultimately, this project revealed that the students were able to conduct research on their own with minimal guidance and that participation in the competition not only generated enjoyment in learning but also their interest in science and research.

Building a science of partnership-focused research: forging and sustaining partnerships to support child mental health prevention and services research.

PubMed

Bradshaw, Catherine P; Haynes, Katherine Taylor

2012-07-01

Building on growing interest in translational research, this paper provides an overview of a special issue of Administration and Policy in Mental Health and Mental Health Service Research, which is focused on the process of forging and sustaining partnerships to support child mental health prevention and services research. We propose that partnership-focused research is a subdiscipline of translational research which requires additional research to better refine the theoretical framework and the core principles that will guide future research and training efforts. We summarize some of the major themes across the eight original articles and three commentaries included in the special issue. By advancing the science of partnership-focused research we will be able to bridge the gap between child mental health prevention and services research and practice.

Space Exploration Technologies Developed through Existing and New Research Partnerships Initiatives

NASA Technical Reports Server (NTRS)

Nall, Mark; Casas, Joseph

2004-01-01

The Space Partnership Development Program of NASA has been highly successful in leveraging commercial research investments to the strategic mission and applied research goals of the Agency through industry academic partnerships. This program is currently undergoing an outward-looking transformation towards Agency wide research and discovery goals that leverage partnership contributions to the strategic research needed to demonstrate enabling space exploration technologies encompassing both robotic spacecraft missions and human space flight. New Space Partnership Initiatives with incremental goals and milestones will allow a continuing series of accomplishments to be achieved throughout the duration of each initiative, permit the "lessons learned" and capabilities acquired from previous implementation steps to be incorporated into subsequent phases of the initiatives, and allow adjustments to be made to the implementation of the initiatives as new opportunities or challenges arise. An Agency technological risk reduction roadmap for any required technologies not currently available will identify the initiative focus areas for the development, demonstration and utilization of space resources supporting the production of power, air, and water, structures and shielding materials. This paper examines the successes to date, lessons learned, and programmatic outlook of enabling sustainable exploration and discovery through governmental, industrial, academic, and international partnerships. Previous government and industry technology development programs have demonstrated that a focused research program that appropriately shares the developmental risk can rapidly mature low Technology Readiness Level (TRL) technologies to the demonstration level. This cost effective and timely, reduced time to discovery, partnership approach to the development of needed technological capabilities addresses the dual use requirements by the investing partners. In addition, these partnerships help to ensure the attainment of complimenting human and robotic exploration goals for NASA while providing additional capabilities for sustainable scientific research benefiting life and security on Earth.

Trace Metal Requirements for Microbial Enzymes Involved in the Production and Consumption of Methane and Nitrous Oxide

PubMed Central

Glass, Jennifer B.; Orphan, Victoria J.

2011-01-01

Fluxes of greenhouse gases to the atmosphere are heavily influenced by microbiological activity. Microbial enzymes involved in the production and consumption of greenhouse gases often contain metal cofactors. While extensive research has examined the influence of Fe bioavailability on microbial CO2 cycling, fewer studies have explored metal requirements for microbial production and consumption of the second- and third-most abundant greenhouse gases, methane (CH4), and nitrous oxide (N2O). Here we review the current state of biochemical, physiological, and environmental research on transition metal requirements for microbial CH4 and N2O cycling. Methanogenic archaea require large amounts of Fe, Ni, and Co (and some Mo/W and Zn). Low bioavailability of Fe, Ni, and Co limits methanogenesis in pure and mixed cultures and environmental studies. Anaerobic methane oxidation by anaerobic methanotrophic archaea (ANME) likely occurs via reverse methanogenesis since ANME possess most of the enzymes in the methanogenic pathway. Aerobic CH4 oxidation uses Cu or Fe for the first step depending on Cu availability, and additional Fe, Cu, and Mo for later steps. N2O production via classical anaerobic denitrification is primarily Fe-based, whereas aerobic pathways (nitrifier denitrification and archaeal ammonia oxidation) require Cu in addition to, or possibly in place of, Fe. Genes encoding the Cu-containing N2O reductase, the only known enzyme capable of microbial N2O conversion to N2, have only been found in classical denitrifiers. Accumulation of N2O due to low Cu has been observed in pure cultures and a lake ecosystem, but not in marine systems. Future research is needed on metalloenzymes involved in the production of N2O by enrichment cultures of ammonia oxidizing archaea, biological mechanisms for scavenging scarce metals, and possible links between metal bioavailability and greenhouse gas fluxes in anaerobic environments where metals may be limiting due to sulfide-metal scavenging. PMID:22363333

Visual soil evaluation - future research requirements

NASA Astrophysics Data System (ADS)

Emmet-Booth, Jeremy; Forristal, Dermot; Fenton, Owen; Ball, Bruce; Holden, Nick

2017-04-01

A review of Visual Soil Evaluation (VSE) techniques (Emmet-Booth et al., 2016) highlighted their established utility for soil quality assessment, though some limitations were identified; (1) The examination of aggregate size, visible intra-porosity and shape forms a key assessment criterion in almost all methods, thus limiting evaluation to structural form. The addition of criteria that holistically examine structure may be desirable. For example, structural stability can be indicated using dispersion tests or examining soil surface crusting, while the assessment of soil colour may indirectly indicate soil organic matter content, a contributor to stability. Organic matter assessment may also indicate structural resilience, along with rooting, earthworm numbers or shrinkage cracking. (2) Soil texture may influence results or impeded method deployment. Modification of procedures to account for extreme texture variation is desirable. For example, evidence of compaction in sandy or single grain soils greatly differs to that in clayey soils. Some procedures incorporate separate classification systems or adjust deployment based on texture. (3) Research into impacts of soil moisture content on VSE evaluation criteria is required. Criteria such as rupture resistance and shape may be affected by moisture content. It is generally recommended that methods are deployed on moist soils and quantification of influences of moisture variation on results is necessary. (4) Robust sampling strategies for method deployment are required. Dealing with spatial variation differs between methods, but where methods can be deployed over large areas, clear instruction on sampling is required. Additionally, as emphasis has been placed on the agricultural production of soil, so the ability of VSE for exploring structural quality in terms of carbon storage, water purification and biodiversity support also requires research. References Emmet-Booth, J.P., Forristal. P.D., Fenton, O., Ball, B.C. & Holden, N.M. 2016. A review of visual soil evaluation techniques for soil structure. Soil Use and Management, 32, 623-634.

Is there a need for a specific educational scholarship for using e-learning in medical education?

PubMed

Sandars, John; Goh, Poh Sun

2016-10-01

We propose the need for a specific educational scholarship when using e-learning in medical education. Effective e-learning has additional factors that require specific critical attention, including the design and delivery of e-learning. An important aspect is the recognition that e-learning is a complex intervention, with several interconnecting components that have to be aligned. This alignment requires an essential iterative development process with usability testing. Effectiveness of e-learning in one context may not be fully realized in another context unless there is further consideration of applicability and scalability. We recommend a participatory approach for an educational scholarship for using e-learning in medical education, such as by action research or design-based research.

Advanced technology needs for a global change science program: Perspective of the Langley Research Center

NASA Technical Reports Server (NTRS)

Rowell, Lawrence F.; Swissler, Thomas J.

1991-01-01

The focus of the NASA program in remote sensing is primarily the Earth system science and the monitoring of the Earth global changes. One of NASA's roles is the identification and development of advanced sensing techniques, operational spacecraft, and the many supporting technologies necessary to meet the stringent science requirements. Langley Research Center has identified the elements of its current and proposed advanced technology development program that are relevant to global change science according to three categories: sensors, spacecraft, and information system technologies. These technology proposals are presented as one-page synopses covering scope, objective, approach, readiness timeline, deliverables, and estimated funding. In addition, the global change science requirements and their measurement histories are briefly discussed.

Free Flight Rotorcraft Flight Test Vehicle Technology Development

NASA Technical Reports Server (NTRS)

Hodges, W. Todd; Walker, Gregory W.

1994-01-01

A rotary wing, unmanned air vehicle (UAV) is being developed as a research tool at the NASA Langley Research Center by the U.S. Army and NASA. This development program is intended to provide the rotorcraft research community an intermediate step between rotorcraft wind tunnel testing and full scale manned flight testing. The technologies under development for this vehicle are: adaptive electronic flight control systems incorporating artificial intelligence (AI) techniques, small-light weight sophisticated sensors, advanced telepresence-telerobotics systems and rotary wing UAV operational procedures. This paper briefly describes the system's requirements and the techniques used to integrate the various technologies to meet these requirements. The paper also discusses the status of the development effort. In addition to the original aeromechanics research mission, the technology development effort has generated a great deal of interest in the UAV community for related spin-off applications, as briefly described at the end of the paper. In some cases the technologies under development in the free flight program are critical to the ability to perform some applications.

The temporal variability of a rainfall synthetic hyetograph for the dimensioning of stormwater retention tanks in small urban catchments

NASA Astrophysics Data System (ADS)

Pochwat, Kamil; Słyś, Daniel; Kordana, Sabina

2017-06-01

The paper presents issues relating to the influence of time distribution of rainfall on the required storage capacity of stormwater reservoirs. The research was based on data derived from simulations of existing drainage systems. The necessary models of catchments and the drainage system were prepared using the hydrodynamic modelling software SWMM 5.0 (Storm Water Management Model). The research results obtained were used to determine the critical rainfall distribution in time which required reserving the highest capacity of stormwater reservoir. In addition, it can be confirmed based on the research that dimensioning of enclosed structures should rely on using the critical precipitation generated as the characteristics of a synthetically developed rainfall vary dynamically in time. In the final part of the paper, the results of the analyses are compared and followed with the ensuing conclusions. The results of the research will have impact on the development of methodologies for dimensioning retention facilities in drainage systems.

Differences in Perception of Classroom Teaching Experience for School Counselor Certification Requirements in Montana.

ERIC Educational Resources Information Center

Nowlin, James; Yazak, Daniel L.

Counselor educators and practitioners have debated the necessity of classroom teaching prior to becoming a school counselor. This research seeks to add to the discussion by presenting the perspective of practicing school counselors and administrators in Montana. Additionally, the study was conducted following a Montana Office of Public Instruction…

Pre-Professional Training for Serving Children with ASD: An Apprenticeship Model of Supervision

ERIC Educational Resources Information Center

Donaldson, Amy L.

2015-01-01

Children with autism spectrum disorder (ASD) often present with varied skill profiles and levels of severity making development and implementation of specialized school services challenging. Research indicates that school professionals require and desire additional ASD-specific professional development, both at the pre-and in-service levels.…

EvoBuild: A Quickstart Toolkit for Programming Agent-Based Models of Evolutionary Processes

ERIC Educational Resources Information Center

Wagh, Aditi; Wilensky, Uri

2018-01-01

Extensive research has shown that one of the benefits of programming to learn about scientific phenomena is that it facilitates learning about mechanisms underlying the phenomenon. However, using programming activities in classrooms is associated with costs such as requiring additional time to learn to program or students needing prior experience…

Factors Influencing Staff Perceptions of Administrator Support for Tier 2 and 3 Interventions: A Multilevel Perspective

ERIC Educational Resources Information Center

Debnam, Katrina J.; Pas, Elise T.; Bradshaw, Catherine P.

2013-01-01

Although the number of schools implementing School-Wide Positive Behavioral Interventions and Supports (SWPBIS) is increasing, and there is great demand for evidence-based Tier 2 and 3 interventions for students requiring additional support, little systematic research has examined administrator support for such programming. This article examines…

Enhancement of Platinum Cathode Catalysis by Addition of Transition Metals

ERIC Educational Resources Information Center

Duong, Hung Tuan

2009-01-01

The sluggish kinetics of oxygen reduction reaction (ORR) contributes significantly to the loss of cathode overpotential in fuel cells, thus requiring high loadings of platinum (Pt), which is an expensive metal with limited supply. However, Pt and Pt-based alloys are still the best available electrocatalysts for ORR thus far. The research presented…

75 FR 53734 - Reports, Forms, and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... Restraint Anchorage Systems), in order to provide another, easier method of attaching a child restraint to... take to improve child passenger safety. In addition, NTHSA will publish the findings of this research... observational data on correct and incorrect use of child restraint systems in passenger vehicles, as well as...

Evaluating a Web-Based Video Corpus through an Analysis of User Interactions

ERIC Educational Resources Information Center

Caws, Catherine G.

2013-01-01

As shown by several studies, successful integration of technology in language learning requires a holistic approach in order to scientifically understand what learners do when working with web-based technology (cf. Raby, 2007). Additionally, a growing body of research in computer assisted language learning (CALL) evaluation, design and…

78 FR 37651 - Agency Information Collection Activities: Request for Comments for a New Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

...- 493-3064, Nondestructive Evaluation Research Program, Federal Highway Administration, Department of... date of enactment of MAP-21. Additionally, MAP-21 included a requirement for a study on the benefits... NHS. The goal of this project shall be to complete a study of the benefits, cost- effectiveness, and...

Beyond the Four Walls: Examining the Use of Authentic Learning Modules

ERIC Educational Resources Information Center

Jagielski, Donna Marie

2016-01-01

While attempting to provide real world experiences in STEM, educators face numerous challenges including adhering to curriculum requirements and working with potentially limited resources. The purpose of this action research study was to examine how the addition of authentic learning modules to the existing University of Arizona Middle School…

Title IX Compliance at Two-Year Colleges: An Analysis of Perceived Barriers and Strategies

ERIC Educational Resources Information Center

Causby, Cory Scott

2010-01-01

Although Title IX legislation has been in effect since 1972 and has created unprecedented positive change on intercollegiate athletics, educational institutions have still had difficulty meeting the basic requirements set forth by Title IX and ensuring gender equity in their athletic programs. Additionally, specific research has been largely…

Job Evaluation in the FE Corporation. Mendip Papers. MP 050.

ERIC Educational Resources Information Center

Saunders, Bob

This report is based on research findings indicating that many British colleges of further education have widely disparate salaries for professional staff members. Often salaries bear no relation to complexity of work performed. In addition, equal employment opportunity laws requiring equal pay for similar work may not be followed. A job…

Occurrence and effects of plastic additives on marine environments and organisms: A review.

PubMed

Hermabessiere, Ludovic; Dehaut, Alexandre; Paul-Pont, Ika; Lacroix, Camille; Jezequel, Ronan; Soudant, Philippe; Duflos, Guillaume

2017-09-01

Plastics debris, especially microplastics, have been found worldwide in all marine compartments. Much research has been carried out on adsorbed pollutants on plastic pieces and hydrophobic organic compounds (HOC) associated with microplastics. However, only a few studies have focused on plastic additives. These chemicals are incorporated into plastics from which they can leach out as most of them are not chemically bound. As a consequence of plastic accumulation and fragmentation in oceans, plastic additives could represent an increasing ecotoxicological risk for marine organisms. The present work reviewed the main class of plastic additives identified in the literature, their occurrence in the marine environment, as well as their effects on and transfers to marine organisms. This work identified polybrominated diphenyl ethers (PBDE), phthalates, nonylphenols (NP), bisphenol A (BPA) and antioxidants as the most common plastic additives found in marine environments. Moreover, transfer of these plastic additives to marine organisms has been demonstrated both in laboratory and field studies. Upcoming research focusing on the toxicity of microplastics should include these plastic additives as potential hazards for marine organisms, and a greater focus on the transport and fate of plastic additives is now required considering that these chemicals may easily leach out from plastics. Copyright © 2017 Elsevier Ltd. All rights reserved.

Vehicle concepts and technology requirements for buoyant heavy-lift systems

NASA Technical Reports Server (NTRS)

Ardema, M. D.

1981-01-01

Several buoyant-vehicle (airship) concepts proposed for short hauls of heavy payloads are described. Numerous studies identified operating cost and payload capacity advantages relative to existing or proposed heavy-lift helicopters for such vehicles. Applications involving payloads of from 15 tons up to 800 tons were identified. The buoyant quad-rotor concept is discussed in detail, including the history of its development, current estimates of performance and economics, currently perceived technology requirements, and recent research and technology development. It is concluded that the buoyant quad-rotor, and possibly other buoyant vehicle concepts, has the potential of satisfying the market for very heavy vertical lift but that additional research and technology development are necessary. Because of uncertainties in analytical prediction methods and small-scale experimental measurements, there is a strong need for large or full-scale experiments in ground test facilities and, ultimately, with a flight research vehicle.

Strategies for application of scientific findings in prevention.

PubMed

Wei, S H

1995-07-01

Dental research in the last 50 years has accomplished numerous significant advances in preventive dentistry, particularly in the area of research in fluorides, periodontal diseases, restorative dentistry, and dental materials, as well as craniofacial development and molecular biology. The transfer of scientific knowledge to clinical practitioners requires additional effort. It is the responsibility of the scientific communities to transfer the fruits of their findings to society through publications, conferences, media, and the press. Specific programs that the International Association for Dental Research (IADR) has developed to transmit science to the profession and the public have included science transfer seminars, the Visiting Lecture Program, and hands-on workshops. The IADR Strategic Plan also has a major outreach goal. In addition, the Federation Dentaire Internationale (FDI) and the World Health Organization (WHO) have initiated plans to celebrate World Health Day and the Year of Oral Health in 1994. These are important strategies for the application of scientific findings in prevention.

Overview of the Icing and Flow Quality Improvements Program for the NASA Glenn Icing Research Tunnel

NASA Technical Reports Server (NTRS)

Irvine, Thomas B.; Kevdzija, Susan L.; Sheldon, David W.; Spera, David A.

2001-01-01

Major upgrades were made in 1999 to the 6- by 9-Foot (1.8- by 2.7-m) Icing Research Tunnel (IRT) at the NASA Glenn Research Center. These included replacement of the electronic controls for the variable-speed drive motor, replacement of the heat exchanger, complete replacement and enlargement of the leg of the tunnel containing the new heat-exchanger, the addition of flow-expanding and flow-contracting turning vanes upstream and downstream of the heat exchanger, respectively, and the addition of fan outlet guide vanes (OGV's). This paper describes the rationale behind this latest program of IRT upgrades and the program's requirements and goals. An overview is given of the scope of work undertaken by the design and construction contractors, the scale-model IRT (SMIRT) design verification program, the comprehensive reactivation test program initiated upon completion of construction, and the overall management approach followed.

Occupational-level interactions between physical hazards and cognitive ability and skill requirements in predicting injury incidence rates.

PubMed

Ford, Michael T; Wiggins, Bryan K

2012-07-01

Interactions between occupational-level physical hazards and cognitive ability and skill requirements were examined as predictors of injury incidence rates as reported by the U. S. Bureau of Labor Statistics. Based on ratings provided in the Occupational Information Network (O*NET) database, results across 563 occupations indicate that physical hazards at the occupational level were strongly related to injury incidence rates. Also, as expected, the physical hazard-injury rate relationship was stronger among occupations with high cognitive ability and skill requirements. In addition, there was an unexpected main effect such that occupations with high cognitive ability and skill requirements had lower injury rates even after controlling for physical hazards. The main effect of cognitive ability and skill requirements, combined with the interaction with physical hazards, resulted in unexpectedly high injury rates for low-ability and low-skill occupations with low physical hazard levels. Substantive and methodological explanations for these interactions and their theoretical and practical implications are offered. Results suggest that organizations and occupational health and safety researchers and practitioners should consider the occupational level of analysis and interactions between physical hazards and cognitive requirements in future research and practice when attempting to understand and prevent injuries.

Research-based recommendations for implementing international service-learning.

PubMed

Amerson, Roxanne

2014-01-01

An increasing number of schools of nursing are incorporating international service-learning and/or immersion experiences into their curriculum to promote cultural competence. The purpose of this paper is to identify research-based recommendations for implementing an international service-learning program. A review of literature was conducted in the Cumulative Index of Nursing and Allied Health Literature database using the keywords international, immersion, cultural competence, nursing, and international service-learning. Additional references were located from the reference lists of related articles. Planning of international or immersion experiences requires consideration of the type of country, the length of time, and design of the program; the use of a service-learning framework; opportunities that require the student to live and work in the community, provide hands-on care, participate in unstructured activities, and make home visits; and a method of reflection. Increasing cultural competence does not require foreign travel, but it does necessitate that students are challenged to move outside their comfort zone and work directly with diverse populations. These research-based recommendations may be used either internationally or locally to promote the most effective service-learning opportunities for nursing students. © 2014.

COVER Project and Earth resources research transition

NASA Technical Reports Server (NTRS)

Botkin, D. B.; Estes, J. E. (Principal Investigator)

1986-01-01

Results of research in the remote sensing of natural boreal forest vegetation (the COVER project) are summarized. The study objectives were to establish a baseline forest test site; develop transforms of LANDSAT MSS and TM data for forest composition, biomass, leaf area index, and net primary productivity; and perform tasks required for testing hypotheses regarding observed spectral responses to changes in leaf area index in aspen. In addition, the transfer and documentation of data collected in the COVER project (removed from the Johnson Space Center following the discontinuation of Earth resources research at that facility) is described.

Speed challenge: a case for hardware implementation in soft-computing

NASA Technical Reports Server (NTRS)

Daud, T.; Stoica, A.; Duong, T.; Keymeulen, D.; Zebulum, R.; Thomas, T.; Thakoor, A.

2000-01-01

For over a decade, JPL has been actively involved in soft computing research on theory, architecture, applications, and electronics hardware. The driving force in all our research activities, in addition to the potential enabling technology promise, has been creation of a niche that imparts orders of magnitude speed advantage by implementation in parallel processing hardware with algorithms made especially suitable for hardware implementation. We review our work on neural networks, fuzzy logic, and evolvable hardware with selected application examples requiring real time response capabilities.

Preliminary results from the High Speed Airframe Integration Research project

NASA Technical Reports Server (NTRS)

Coen, Peter G.; Sobieszczanski-Sobieski, Jaroslaw; Dollyhigh, Samuel M.

1992-01-01

A review is presented of the accomplishment of the near term objectives of developing an analysis system and optimization methods during the first year of the NASA Langley High Speed Airframe Integration Research (HiSAIR) project. The characteristics of a Mach 3 HSCT transport have been analyzed utilizing the newly developed process. In addition to showing more detailed information about the aerodynamic and structural coupling for this type of vehicle, this exercise aided in further refining the data requirements for the analysis process.

Review of coaxial flow gas core nuclear rocket fluid mechanics

NASA Technical Reports Server (NTRS)

Weinstein, H.

1976-01-01

Almost all of the fluid mechanics research associated with the coaxial flow gas core reactor ended abruptly with the interruption of NASA's space nuclear program because of policy and budgetary considerations in 1973. An overview of program accomplishments is presented through a review of the experiments conducted and the analyses performed. Areas are indicated where additional research is required for a fuller understanding of cavity flow and of the factors which influence cold and hot flow containment. A bibliography is included with graphic material.

Implementing Network Common Data Form (netCDF) for the 3DWF Model

DTIC Science & Technology

2016-02-01

format. In addition, data extraction from netCDF-formatted Weather Research and Forecasting ( WRF ) model results necessary for the 3DWF model’s wind...Requirement for the 3DWF Model 1 3. Implementing netCDF to the 3DWF Model 2 3.1 Weather Research and Forecasting ( WRF ) domain and results 3 3.2...Extracting Variables from netCDF Formatted WRF Data File 5 3.3 Converting the 3DWF’s Results into netCDF 11 4. Conclusion 14 5. References 15 Appendix

Adapting Rational Unified Process (RUP) approach in designing a secure e-Tendering model

NASA Astrophysics Data System (ADS)

Mohd, Haslina; Robie, Muhammad Afdhal Muhammad; Baharom, Fauziah; Darus, Norida Muhd; Saip, Mohamed Ali; Yasin, Azman

2016-08-01

e-Tendering is an electronic processing of the tender document via internet and allow tenderer to publish, communicate, access, receive and submit all tender related information and documentation via internet. This study aims to design the e-Tendering system using Rational Unified Process approach. RUP provides a disciplined approach on how to assign tasks and responsibilities within the software development process. RUP has four phases that can assist researchers to adjust the requirements of various projects with different scope, problem and the size of projects. RUP is characterized as a use case driven, architecture centered, iterative and incremental process model. However the scope of this study only focusing on Inception and Elaboration phases as step to develop the model and perform only three of nine workflows (business modeling, requirements, analysis and design). RUP has a strong focus on documents and the activities in the inception and elaboration phases mainly concern the creation of diagrams and writing of textual descriptions. The UML notation and the software program, Star UML are used to support the design of e-Tendering. The e-Tendering design based on the RUP approach can contribute to e-Tendering developers and researchers in e-Tendering domain. In addition, this study also shows that the RUP is one of the best system development methodology that can be used as one of the research methodology in Software Engineering domain related to secured design of any observed application. This methodology has been tested in various studies in certain domains, such as in Simulation-based Decision Support, Security Requirement Engineering, Business Modeling and Secure System Requirement, and so forth. As a conclusion, these studies showed that the RUP one of a good research methodology that can be adapted in any Software Engineering (SE) research domain that required a few artifacts to be generated such as use case modeling, misuse case modeling, activity diagram, and initial class diagram from a list of requirements as identified earlier by the SE researchers

Research Institute for Advanced Computer Science: Annual Report October 1998 through September 1999

NASA Technical Reports Server (NTRS)

Leiner, Barry M.; Gross, Anthony R. (Technical Monitor)

1999-01-01

The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. RIACS is located at the NASA Ames Research Center (ARC). It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in the year 2002. ARC has been designated NASA's Center of Excellence in Information Technology. In this capacity, ARC is charged with the responsibility to build an Information Technology Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA ARC and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of information technology research necessary to meet the future challenges of NASA missions: (1) Automated Reasoning for Autonomous Systems. Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth. (2) Human-Centered Computing. Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities; (3) High Performance Computing and Networking Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to data analysis of large datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply information technology research to a variety of NASA application domains. RIACS also engages in other activities, such as workshops, seminars, and visiting scientist programs, designed to encourage and facilitate collaboration between the university and NASA information technology research communities.

Research Institute for Advanced Computer Science

NASA Technical Reports Server (NTRS)

Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

2000-01-01

The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. RIACS is located at the NASA Ames Research Center. It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in the year 2002. Ames has been designated NASA's Center of Excellence in Information Technology. In this capacity, Ames is charged with the responsibility to build an Information Technology Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA Ames and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of information technology research necessary to meet the future challenges of NASA missions: (1) Automated Reasoning for Autonomous Systems. Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth; (2) Human-Centered Computing. Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities; (3) High Performance Computing and Networking. Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to data analysis of large datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply information technology research to a variety of NASA application domains. RIACS also engages in other activities, such as workshops, seminars, and visiting scientist programs, designed to encourage and facilitate collaboration between the university and NASA information technology research communities.

Propulsion/flight control integration technology (PROFIT) design analysis status

NASA Technical Reports Server (NTRS)

Carlin, C. M.; Hastings, W. J.

1978-01-01

The propulsion flight control integration technology (PROFIT) program was designed to develop a flying testbed dedicated to controls research. The preliminary design, analysis, and feasibility studies conducted in support of the PROFIT program are reported. The PROFIT system was built around existing IPCS hardware. In order to achieve the desired system flexibility and capability, additional interfaces between the IPCS hardware and F-15 systems were required. The requirements for additions and modifications to the existing hardware were defined. Those interfaces involving the more significant changes were studied. The DCU memory expansion to 32K with flight qualified hardware was completed on a brassboard basis. The uplink interface breadboard and a brassboard of the central computer interface were also tested. Two preliminary designs and corresponding program plans are presented.

Regulatory and ethical issues with dietary supplements.

PubMed

Harris, I M

2000-11-01

Dietary supplements are commonly used, and many are effective or hold promise for treating various conditions. However, they do not require Food and Drug Administration (FDA) approval. Impurities and adulterants have been found in the products, mostly due to the lack of requirements for good manufacturing practices. In addition, as no standardization is required, the active ingredient may be absent or highly variable among manufacturers. The FDA published its 10-year plan for dietary supplements that addresses safety, labeling, boundaries, enforcement, research, and outreach. This endeavor, if put into place, will be instrumental in providing consumers with more confidence in the safety, composition, and labeling of dietary supplements.

CRM Assessment: Determining the Generalization of Rater Calibration Training. Summary of Research Report: Gold Standards Training

NASA Technical Reports Server (NTRS)

Baker, David P.

2002-01-01

The extent to which pilot instructors are trained to assess crew resource management (CRM) skills accurately during Line-Oriented Flight Training (LOFT) and Line Operational Evaluation (LOE) scenarios is critical. Pilot instructors must make accurate performance ratings to ensure that proper feedback is provided to flight crews and appropriate decisions are made regarding certification to fly the line. Furthermore, the Federal Aviation Administration's (FAA) Advanced Qualification Program (AQP) requires that instructors be trained explicitly to evaluate both technical and CRM performance (i.e., rater training) and also requires that proficiency and standardization of instructors be verified periodically. To address the critical need for effective pilot instructor training, the American Institutes for Research (AIR) reviewed the relevant research on rater training and, based on "best practices" from this research, developed a new strategy for training pilot instructors to assess crew performance. In addition, we explored new statistical techniques for assessing the effectiveness of pilot instructor training. The results of our research are briefly summarized below. This summary is followed by abstracts of articles and book chapters published under this grant.

Airborne Subscale Transport Aircraft Research Testbed: Aircraft Model Development

NASA Technical Reports Server (NTRS)

Jordan, Thomas L.; Langford, William M.; Hill, Jeffrey S.

2005-01-01

The Airborne Subscale Transport Aircraft Research (AirSTAR) testbed being developed at NASA Langley Research Center is an experimental flight test capability for research experiments pertaining to dynamics modeling and control beyond the normal flight envelope. An integral part of that testbed is a 5.5% dynamically scaled, generic transport aircraft. This remotely piloted vehicle (RPV) is powered by twin turbine engines and includes a collection of sensors, actuators, navigation, and telemetry systems. The downlink for the plane includes over 70 data channels, plus video, at rates up to 250 Hz. Uplink commands for aircraft control include over 30 data channels. The dynamic scaling requirement, which includes dimensional, weight, inertial, actuator, and data rate scaling, presents distinctive challenges in both the mechanical and electrical design of the aircraft. Discussion of these requirements and their implications on the development of the aircraft along with risk mitigation strategies and training exercises are included here. Also described are the first training (non-research) flights of the airframe. Additional papers address the development of a mobile operations station and an emulation and integration laboratory.

Partner or perish: experiences from the field about collaborations for reform.

PubMed

Boyer, Kim; Orpin, Peter; Walker, Judith

2010-01-01

Collaborations between researchers, policy makers, service providers and community members are critical to the journey of health service reform. Challenges are multifaceted and complex. Partners come with a variety of challenging agendas, value sets and imperatives, and see the drivers for reform from different perspectives. Different skills are required for managing the partnership and for providing academic leadership, and different structural frameworks need to be put in place for each task in each project. We have found through a series of partnerships across our research theme of healthy ageing, and consequent translation into policy and practice, that significant and innovative effort is required for both the collaboration and the research to succeed. A shared understanding of the issues and challenges is a start, but not sufficient for longer-term success. In addition to managing the research, our experience has demonstrated the need to understand the different challenges faced by each of the partners, recognise and respect personal and organisational value systems, and to establish separate mechanisms to manage strong egos alongside, but outside of, the research process.

National Science Foundation-sponsored workshop report. Draft plan for soybean genomics.

PubMed

Stacey, Gary; Vodkin, Lila; Parrott, Wayne A; Shoemaker, Randy C

2004-05-01

Recent efforts to coordinate and define a research strategy for soybean (Glycine max) genomics began with the establishment of a Soybean Genetics Executive Committee, which will serve as a communication focal point between the soybean research community and granting agencies. Secondly, a workshop was held to define a strategy to incorporate existing tools into a framework for advancing soybean genomics research. This workshop identified and ranked research priorities essential to making more informed decisions as to how to proceed with large scale sequencing and other genomics efforts. Most critical among these was the need to finalize a physical map and to obtain a better understanding of genome microstructure. Addressing these research needs will require pilot work on new technologies to demonstrate an ability to discriminate between recently duplicated regions in the soybean genome and pilot projects to analyze an adequate amount of random genome sequence to identify and catalog common repeats. The development of additional markers, reverse genetics tools, and bioinformatics is also necessary. Successful implementation of these goals will require close coordination among various working groups.

The role of insurance claims databases in drug therapy outcomes research.

PubMed

Lewis, N J; Patwell, J T; Briesacher, B A

1993-11-01

The use of insurance claims databases in drug therapy outcomes research holds great promise as a cost-effective alternative to post-marketing clinical trials. Claims databases uniquely capture information about episodes of care across healthcare services and settings. They also facilitate the examination of drug therapy effects on cohorts of patients and specific patient subpopulations. However, there are limitations to the use of insurance claims databases including incomplete diagnostic and provider identification data. The characteristics of the population included in the insurance plan, the plan benefit design, and the variables of the database itself can influence the research results. Given the current concerns regarding the completeness of insurance claims databases, and the validity of their data, outcomes research usually requires original data to validate claims data or to obtain additional information. Improvements to claims databases such as standardisation of claims information reporting, addition of pertinent clinical and economic variables, and inclusion of information relative to patient severity of illness, quality of life, and satisfaction with provided care will enhance the benefit of such databases for outcomes research.

The safety and efficacy of contact lens wear in the industrial and chemical workplace.

PubMed

Tyhurst, Keith; McNett, Ryan; Bennett, Edward

2007-11-01

The use and safety of contact lenses in the industrial and chemical workplace has often been questioned since the 1960s because of many unconfirmed reports of ocular injury resulting from contact lens wear. Because of these urban legends, contact lens wear has been banned or wearers have been required to wear additional personal protective equipment (PPE) not required of non-contact lens wearers. Literature review via Medline and Google search. Research has shown that contact lenses typically provide protective benefits that decrease the severity of ocular injury and improve worker performance. While contact lens wear contraindications do exist, in most cases, and with proper precautions, contact lens wear is still possible. Industrial and chemical companies need to establish written contact lens use policies based on current studies that have shown the safety of workplace contact lens wear when combined with the same PPE required of non-contact lens wearers. Practitioners need to discuss, with their contact lens patients, the additional responsibilities required to maintain proper lens hygiene and proper PPE in the workplace.

Research Priorities for Endometriosis.

PubMed

Rogers, Peter A W; Adamson, G David; Al-Jefout, Moamar; Becker, Christian M; D'Hooghe, Thomas M; Dunselman, Gerard A J; Fazleabas, Asgerally; Giudice, Linda C; Horne, Andrew W; Hull, M Louise; Hummelshoj, Lone; Missmer, Stacey A; Montgomery, Grant W; Stratton, Pamela; Taylor, Robert N; Rombauts, Luk; Saunders, Philippa T; Vincent, Katy; Zondervan, Krina T

2017-02-01

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17-20, 2017, in Vancouver, British Columbia, Canada.

Research Priorities for Endometriosis

PubMed Central

Rogers, Peter A. W.; Adamson, G. David; Al-Jefout, Moamar; Becker, Christian M.; D’Hooghe, Thomas M.; Dunselman, Gerard A. J.; Fazleabas, Asgerally; Giudice, Linda C.; Horne, Andrew W.; Hull, M. Louise; Hummelshoj, Lone; Missmer, Stacey A.; Montgomery, Grant W.; Stratton, Pamela; Taylor, Robert N.; Rombauts, Luk; Saunders, Philippa T.; Vincent, Katy; Zondervan, Krina T.; Adamson, G. David

2016-01-01

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17–20, 2017, in Vancouver, British Columbia, Canada. PMID:27368878

The Canadian National EMS Research Agenda: Impact and Feasibility of Implementation of Previously Generated Recommendations.

PubMed

Jensen, J L; Blanchard, I E; Bigham, B L; Carter, Aje; Brown, R; Socha, D; Brown, L H; Travers, A H; Craig, A M; Morrison, L J

2015-09-01

A recent mixed-methods study on the state of emergency medical services (EMS) research in Canada led to the generation of nineteen actionable recommendations. As part of the dissemination plan, a survey was distributed to EMS stakeholders to determine the anticipated impact and feasibility of implementing these recommendations in Canadian systems. An online survey explored both the implementation impact and feasibility for each recommendation using a five-point scale. The sample consisted of participants from the Canadian National EMS Research Agenda study (published in 2013) and additional EMS research stakeholders identified through snowball sampling. Responses were analysed descriptively using median and plotted on a matrix. Participants reported any planned or ongoing initiatives related to the recommendations, and required or anticipated resources. Free text responses were analysed with simple content analysis, collated by recommendation. The survey was sent to 131 people, 94 (71.8%) of whom responded: 30 EMS managers/regulators (31.9%), 22 researchers (23.4%), 15 physicians (16.0%), 13 educators (13.8%), and 5 EMS providers (5.3%). Two recommendations (11%) had a median impact score of 4 (of 5) and feasibility score of 4 (of 5). Eight recommendations (42%) had an impact score of 5, with a feasibility score of 3. Nine recommendations (47%) had an impact score of 4 and a feasibility score of 3. For most recommendations, participants scored the anticipated impact higher than the feasibility to implement. Ongoing or planned initiatives exist pertaining to all recommendations except one. All of the recommendations will require additional resources to implement.

Material requirements for the High Speed Civil Transport

NASA Technical Reports Server (NTRS)

Stephens, Joseph R.; Hecht, Ralph J.; Johnson, Andrew M.

1993-01-01

Under NASA-sponsored High Speed Research (HSR) programs, the materials and processing requirements have been identified for overcoming the environmental and economic barriers of the next generation High Speed Civil Transport (HSCT) propulsion system. The long (2 to 5 hours) supersonic cruise portion of the HSCT cycle will place additional durability requirements on all hot section engine components. Low emissions combustor designs will require high temperature ceramic matrix composite liners to meet an emission goal of less than 5g NO(x) per Kg fuel burned. Large axisymmetric and two-dimensional exhaust nozzle designs are now under development to meet or exceed FAR 36 Stage III noise requirements, and will require lightweight, high temperature metallic, intermetallic, and ceramic matrix composites to reduce nozzle weight and meet structural and acoustic component performance goals. This paper describes and discusses the turbomachinery, combustor, and exhaust nozzle requirements of the High Speed Civil Transport propulsion system.

Raising awareness of the importance of funding for tuberculosis small-molecule research.

PubMed

Riccardi, Giovanna; Old, Iain G; Ekins, Sean

2017-03-01

Tuberculosis (TB) drug discovery research is hampered by several factors, but as in many research areas, the available funding is insufficient to support the needs of research and development. Recent years have seen various large collaborative efforts involving public-private partnerships, mimicking the situation during the golden age of antibiotic drug discovery during the 1950s and 1960s. The large-scale collaborative efforts funded by the European Union (EU) are now subject to diminishing financial support. As a result, TB researchers are increasingly looking for novel forms of funding, such as crowdfunding, to fill this gap. Any potential solution will require a careful reassessment of the incentives to encourage additional organizations to provide funding. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Practical Guide for Improving Transparency and Reproducibility in Neuroimaging Research

PubMed Central

Poldrack, Russell A.

2016-01-01

Recent years have seen an increase in alarming signals regarding the lack of replicability in neuroscience, psychology, and other related fields. To avoid a widespread crisis in neuroimaging research and consequent loss of credibility in the public eye, we need to improve how we do science. This article aims to be a practical guide for researchers at any stage of their careers that will help them make their research more reproducible and transparent while minimizing the additional effort that this might require. The guide covers three major topics in open science (data, code, and publications) and offers practical advice as well as highlighting advantages of adopting more open research practices that go beyond improved transparency and reproducibility. PMID:27389358

Social scientific paradigms of masculinity and their implications for research and practice in men's mental health.

PubMed

Addis, Michael E; Cohane, Geoffrey H

2005-06-01

Clinical researchers and practitioners are increasingly aware of the need for quality theory, research, and intervention in men's mental health. Successful work in this area requires an understanding of the multitude of ways that gender, and more specifically masculinities, can be conceptualized beyond a sole focus on sex differences between men and women. Drawing from a range of social sciences in addition to psychology, the authors consider several theoretical, research, and clinical directions that can follow from social learning, psychodynamic, social constructionist, and feminist paradigms. It is concluded that thinking deeply and critically within different paradigms of masculinity is critical for progress in both research and practice. Copyright 2005 Wiley Periodicals, Inc.

DMPwerkzeug - A tool to support the planning, implementation, and organization of research data management.

NASA Astrophysics Data System (ADS)

Klar, Jochen; Engelhardt, Claudia; Neuroth, Heike; Enke, Harry

2016-04-01

Following the call to make the results of publicly funded research openly accessible, more and more funding agencies demand the submission of a data management plan (DMP) as part of the application process. These documents specify, how the data management of the project is organized and what datasets will be published when. Of particular importance for European researchers is the Open Data Research Pilot of Horizon 2020 which requires data management plans for a set of 9 selected research fields from social sciences to nanotechnology. In order to assist the researchers creating these documents, several institutions developed dedicated software tools. The most well-known are DMPonline by the Digital Curation Centre (DCC) and DMPtool by the California Digital Library (CDL) - both extensive and well received web applications. The core functionality of these tools is the assisted editing of the DMP templates provided by the particular funding agency.While this is certainly helpful, especially in an environment with a plethora of different funding agencies like the UK or the USA, these tools are somewhat limited to this particular task and don't utilise the full potential of DMP. Beyond the purpose of fulfilling funder requirements, DMP can be useful for a number of additional tasks. In the initial conception phase of a project, they can be used as a planning tool to determine which date management activities and measures are necessary throughout the research process, to assess which resources are needed, and which institutions (computing centers, libraries, data centers) should be involved. During the project, they can act as a constant reference or guideline for the handling of research data. They also determine where the data will be stored after the project has ended and whether it can be accessed by the public, helping to take into account resulting requirements of the data center or actions necessary to ensure re-usability by others from early on. Ideally, a DMP acts as information source for all stakeholders involved during the complete life cycle of the project. The aim our project is the development of a web application called DMPwerkzeug, which enables this structured planning, implementation and administration of the research data management in a scientific project and, in addition, provides the scientist with a textual DMP. Building upon a generic set of content, DMPwerkzeug will be customizable to serve specific disciplinary and institutional requirements. The tool will not only be available at a central web site, but will be able to be installed and integrated into the existing infrastructure of a university or research institution. The tool will be multilingual, with a first version being published in English and German.

Computer Science Research at Langley

NASA Technical Reports Server (NTRS)

Voigt, S. J. (Editor)

1982-01-01

A workshop was held at Langley Research Center, November 2-5, 1981, to highlight ongoing computer science research at Langley and to identify additional areas of research based upon the computer user requirements. A panel discussion was held in each of nine application areas, and these are summarized in the proceedings. Slides presented by the invited speakers are also included. A survey of scientific, business, data reduction, and microprocessor computer users helped identify areas of focus for the workshop. Several areas of computer science which are of most concern to the Langley computer users were identified during the workshop discussions. These include graphics, distributed processing, programmer support systems and tools, database management, and numerical methods.

Free-space optical communications research and demonstrations at the U.S. Naval Research Laboratory.

PubMed

Rabinovich, W S; Moore, C I; Mahon, R; Goetz, P G; Burris, H R; Ferraro, M S; Murphy, J L; Thomas, L M; Gilbreath, G C; Vilcheck, M; Suite, M R

2015-11-01

Free-space optical communication can allow high-bandwidth data links that are hard to detect, intercept, or jam. This makes them attractive for many applications. However, these links also require very accurate pointing, and their availability is affected by weather. These challenges have limited the deployment of free-space optical systems. The U.S. Naval Research Laboratory has, for the last 15 years, engaged in research into atmospheric propagation and photonic components with a goal of characterizing and overcoming these limitations. In addition several demonstrations of free-space optical links in real-world Navy applications have been conducted. This paper reviews this work and the principles guiding it.

Recent Investments by NASA's National Force Measurement Technology Capability

NASA Technical Reports Server (NTRS)

Commo, Sean A.; Ponder, Jonathan D.

2016-01-01

The National Force Measurement Technology Capability (NFMTC) is a nationwide partnership established in 2008 and sponsored by NASA's Aeronautics Evaluation and Test Capabilities (AETC) project to maintain and further develop force measurement capabilities. The NFMTC focuses on force measurement in wind tunnels and provides operational support in addition to conducting balance research. Based on force measurement capability challenges, strategic investments into research tasks are designed to meet the experimental requirements of current and future aerospace research programs and projects. This paper highlights recent and force measurement investments into several areas including recapitalizing the strain-gage balance inventory, developing balance best practices, improving calibration and facility capabilities, and researching potential technologies to advance balance capabilities.

Market structure and advertising in the U.S. pharmaceutical industry: some implications for public policy.

PubMed

Hornbrook, M C

1978-02-01

Distortions in market processes for pharmaceuticals raise the important policy problem of devising measures to improve industry performance. This paper first reviews the basic issues involved in formulating economic policy regarding the pharmaceutical industry. Methods for reducing structural market power and undesirable promotional expenditures are examined, and the impacts of four oft-suggested policy "reforms"--removal of trade names, removal of patents, relaxation of requirements for certification of new drug products, and increased enforcement of antitrust laws--are then analyzed. Finally, problems requiring additional research are identified.

Potential of laser for SPS power transmission

NASA Technical Reports Server (NTRS)

Bain, C. N.

1978-01-01

Research on the feasibility of using a laser subsystem as an additional option for the transmission of the satellite power system (STS) power is presented. Current laser work and predictions for future laser performance provide a level of confidence that the development of a laser power transmission system is technologically feasible in the time frame required to develop the SBS. There are significant economic advantages in lower ground distribution costs and a reduction of more than two orders of magnitude in real estate requirements for ground based receiving/conversion sites.

Bringing Federated Identity to Grid Computing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teheran, Jeny

The Fermi National Accelerator Laboratory (FNAL) is facing the challenge of providing scientific data access and grid submission to scientific collaborations that span the globe but are hosted at FNAL. Users in these collaborations are currently required to register as an FNAL user and obtain FNAL credentials to access grid resources to perform their scientific computations. These requirements burden researchers with managing additional authentication credentials, and put additional load on FNAL for managing user identities. Our design integrates the existing InCommon federated identity infrastructure, CILogon Basic CA, and MyProxy with the FNAL grid submission system to provide secure access formore » users from diverse experiments and collab orations without requiring each user to have authentication credentials from FNAL. The design automates the handling of certificates so users do not need to manage them manually. Although the initial implementation is for FNAL's grid submission system, the design and the core of the implementation are general and could be applied to other distributed computing systems.« less

76 FR 43745 - Magnuson-Stevens Fishery Conservation and Management Act (MSA) Provisions; Fisheries of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

...NMFS hereby implements measures approved in Amendment 15 to the Scallop FMP (Amendment 15), which was developed by the New England Fishery Management Council (Council). Amendment 15 was developed primarily to implement annual catch limits (ACLs) and accountability measures (AMs) to bring the Scallop FMP into compliance with requirements of the MSA as reauthorized in 2007. Amendment 15 includes additional measures recommended by the Council, including: A revision of the overfishing definition (OFD); modification of the essential fish habitat (EFH) closed areas under the Scallop FMP; adjustments to measures for the Limited Access General Category (LAGC) individual fishing quota (IFQ) fishery; adjustments to the scallop research set- aside (RSA) program; and additions to the list of measures that can be adjusted by framework adjustments. NMFS has disapproved a provision that would have allocated additional scallop catch to the LAGC fleet because it was not consistent with National Standard 1 and the ACL requirement of the MSA.

48 CFR 227.7004 - Requirements for filing an administrative claim for patent infringement.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Office file of each patent if available to claimant. (11) Pertinent prior art known to claimant, not contained in the Patent Office file, particularly publications and foreign art. In addition in the foregoing...) For the Department of the Navy—the Patent Counsel for Navy, Office of Naval Research; (3) For the...

The Association between Medical Education Accreditation and Examination Performance of Internationally Educated Physicians Seeking Certification in the United States

ERIC Educational Resources Information Center

van Zanten, Marta; Boulet, John R.

2013-01-01

The purposes of this research were to examine medical education accreditation practices around the world, with special focus on the Caribbean, and to explore the association between medical school accreditation and graduates' examination performance. In addition to other requirements, graduates of international medical schools seeking to enter…

Self-Monitoring as a Means to Generalize Social Skills

ERIC Educational Resources Information Center

Childs, Deborah

2012-01-01

Social skills are important for success in school as well as in life. Social skills training (SST) has been effective in teaching students required skills within the context of the training site, but often these have not generalized to additional settings (DuPaul & Eckert, 1994). This study researches the effect of adding self-management to an…

Collaboration, Communication, and Connection: Collegial Support and Collective Efficacy among Health Science Teachers

ERIC Educational Resources Information Center

Loera, Gustavo; Nakamoto, Jonathan; Rueda, Robert; Oh, Youn Joo; Beck, Cindy; Cherry, Carla

2013-01-01

The social and collaborative aspects of work settings are becoming increasingly important. For example, recent research has placed emphasis on the social nature of learning. In addition, many authors have suggested that 21st century skills that will be required in future work and professional environments will involve collaborative skills, making…

Improving K-12 Online Learning: Information Literacy Skills for Teacher Candidates

ERIC Educational Resources Information Center

Ntuli, Esther; Kyei-Blankson, Lydia

2016-01-01

Research indicates the need for teachers to be able to locate, evaluate, and use Internet resources in their teaching and learning processes. In addition, the Common Core State Standards require that students are able to think critically and know how to search and use alternative views and perspectives in their assignments. These skills are…

Between Counting and Multiplication: Low-Attaining Students' Spatial Structuring, Enumeration and Errors in Concretely-Presented 3D Array Tasks

ERIC Educational Resources Information Center

Finesilver, Carla

2017-01-01

The move from additive to multiplicative thinking requires significant change in children's comprehension and manipulation of numerical relationships, involves various conceptual components, and can be a slow, multistage process for some. Unit arrays are a key visuospatial representation for supporting learning, but most research focuses on 2D…

Capturing & Reusing Air Handler Condensate without Digging up the Campus

ERIC Educational Resources Information Center

Pruitt, Olen L.; Guccione, Patrick D.

2013-01-01

The University of Alabama at Birmingham (UAB) has experienced rapid growth in the last decade. In addition to educating over 17,000 students annually, UAB is a major research facility and academic healthcare center. Due to growth and expansion, UAB requires more and more water to sustain operations. The central chilled water system serves over…

Students' Understanding of Primary and Secondary Protein Structure: Drawing Secondary Protein Structure Reveals Student Understanding Better than Simple Recognition of Structures

ERIC Educational Resources Information Center

Harle, Marissa; Towns, Marcy H.

2013-01-01

The interdisciplinary nature of biochemistry courses requires students to use both chemistry and biology knowledge to understand biochemical concepts. Research that has focused on external representations in biochemistry has uncovered student difficulties in comprehending and interpreting external representations in addition to a fragmented…

Identification of Fluency and Word-Finding Difficulty in Samples of Children with Diverse Language Backgrounds

ERIC Educational Resources Information Center

Howell, Peter; Tang, Kevin; Tuomainen, Outi; Chan, Sin Kan; Beltran, Kirsten; Mirawdeli, Avin; Harris, John

2017-01-01

Background: Stuttering and word-finding difficulty (WFD) are two types of communication difficulty that occur frequently in children who learn English as an additional language (EAL), as well as those who only speak English. The two disorders require different, specific forms of intervention. Prior research has described the symptoms of each type…

Calibration Study of POWER Performance Levels to the CASAS Scale. Research Brief No. 5

ERIC Educational Resources Information Center

Posey, Virginia

2005-01-01

The Adult Education and Family Literacy Act, as part of the Workforce Investment Act of 1998, requires programs to use standardized assessments to report learning gains for students in adult education programs. In addition, local and state agencies need an accountability tool for students who are difficult to assess adequately with a…

[Discursive thought and intuition in medical research].

PubMed

Labhart, A

1981-02-01

The history of diabetes and the progress of the sciences demonstrates that original creative investigation requires in addition to logic thinking intuition which originates from the unconscious. The concept of intuition is of great importance in philosophy, religion and psychology. Luck and serendipity have similar meaning as the concepts of kairos, tyche and techne of the Greek.

Investigation of Demographic Properties and Motivation Factors of Physics Teachers

ERIC Educational Resources Information Center

Guzel, Hatice

2011-01-01

Scientific and technological developments resulted in an increase in the requirement of education in the society. In addition to this, the expectations from teachers differed and the need for more qualified teachers also increased. One of the factors affecting the quality of teachers is their motivation. In this research, it was aimed to reveal…

A Legal Analysis of Federal Disability Law as Related to Emerging Technology: Guidelines for Postsecondary Leadership, Policy, and Practice

ERIC Educational Resources Information Center

Ford, Roderick Dwayne

2014-01-01

This dissertation identified and described the legal requirements imposed by federal disability mandates and case law related to emerging technology. Additionally, the researcher created a legal framework (guidelines) for higher education institutions to consider during policy development and implementation of emerging technology by providing an…

48 CFR 227.7004 - Requirements for filing an administrative claim for patent infringement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Office file of each patent if available to claimant. (11) Pertinent prior art known to claimant, not contained in the Patent Office file, particularly publications and foreign art. In addition in the foregoing...) For the Department of the Navy—the Patent Counsel for Navy, Office of Naval Research; (3) For the...

48 CFR 227.7004 - Requirements for filing an administrative claim for patent infringement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Office file of each patent if available to claimant. (11) Pertinent prior art known to claimant, not contained in the Patent Office file, particularly publications and foreign art. In addition in the foregoing...) For the Department of the Navy—the Patent Counsel for Navy, Office of Naval Research; (3) For the...

48 CFR 227.7004 - Requirements for filing an administrative claim for patent infringement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Office file of each patent if available to claimant. (11) Pertinent prior art known to claimant, not contained in the Patent Office file, particularly publications and foreign art. In addition in the foregoing...) For the Department of the Navy—the Patent Counsel for Navy, Office of Naval Research; (3) For the...

48 CFR 227.7004 - Requirements for filing an administrative claim for patent infringement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Office file of each patent if available to claimant. (11) Pertinent prior art known to claimant, not contained in the Patent Office file, particularly publications and foreign art. In addition in the foregoing...) For the Department of the Navy—The Patent Counsel for Navy, Office of Naval Research; (3) For the...

Combustion Research aboard the ISS Utilizing the Combustion Integrated Rack and Microgravity Science Glovebox

NASA Astrophysics Data System (ADS)

Sutliff, T. J.; Otero, A. M.; Urban, D. L.

2002-01-01

The Physical Sciences Research Program of NASA has chartered a broad suite of peer-reviewed research investigating both fundamental combustion phenomena and applied combustion research topics. Fundamental research provides insights to develop accurate simulations of complex combustion processes and allows developers to improve the efficiency of combustion devices, to reduce the production of harmful emissions, and to reduce the incidence of accidental uncontrolled combustion (fires, explosions). The applied research benefit humans living and working in space through its fire safety program. The Combustion Science Discipline is implementing a structured flight research program utilizing the International Space Station (ISS) and two of its premier facilities, the Combustion Integrated Rack of the Fluids and Combustion Facility and the Microgravity Science Glovebox to conduct this space-based research. This paper reviews the current vision of Combustion Science research planned for International Space Station implementation from 2003 through 2012. A variety of research efforts in droplets and sprays, solid-fuels combustion, and gaseous combustion have been independently selected and critiqued through a series of peer-review processes. During this period, while both the ISS carrier and its research facilities are under development, the Combustion Science Discipline has synergistically combined research efforts into sub-topical areas. To conduct this research aboard ISS in the most cost effective and resource efficient manner, the sub-topic research areas are implemented via a multi-user hardware approach. This paper also summarizes the multi-user hardware approach and recaps the progress made in developing these research hardware systems. A balanced program content has been developed to maximize the production of fundamental and applied combustion research results within the current budgetary and ISS operational resource constraints. Decisions on utilizing the Combustion Integrated Rack and the Microgravity Science Glovebox are made based on facility capabilities and research requirements. To maximize research potential, additional research objectives are specified as desires a priori during the research design phase. These expanded research goals, which are designed to be achievable even with late addition of operational resources, allow additional research of a known, peer-endorsed scope to be conducted at marginal cost. Additional operational resources such as upmass, crewtime, data downlink bandwidth, and stowage volume may be presented by the ISS planners late in the research mission planning process. The Combustion Discipline has put in place plans to be prepared to take full advantage of such opportunities.

A potential role of anti-poverty programs in health promotion

PubMed Central

Silverman, Kenneth; Holtyn, August F.; Jarvis, Brantley

2016-01-01

Poverty is one of the most pervasive risk factors underlying poor health, but is rarely targeted to improve health. Research on the effects of anti-poverty interventions on health has been limited, at least in part because funding for that research has been limited. Anti-poverty programs have been applied on a large scale, frequently by governments, but without systematic development and cumulative programmatic experimental studies. Anti-poverty programs that produce lasting effects on poverty have not been developed. Before evaluating the effect of anti-poverty programs on health, programs must be developed that can reduce poverty consistently. Anti-poverty programs require systematic development and cumulative programmatic scientific evaluation. Research on the therapeutic workplace could provide a model for that research and an adaptation of the therapeutic workplace could serve as a foundation of a comprehensive anti-poverty program. Once effective anti-poverty programs are developed, future research could determine if those programs improve health in addition to increasing income. The potential personal, health and economic benefits of effective anti-poverty programs could be substantial, and could justify the major efforts and expenses that would be required to support systematic research to develop such programs. PMID:27235603

A potential role of anti-poverty programs in health promotion.

PubMed

Silverman, Kenneth; Holtyn, August F; Jarvis, Brantley P

2016-11-01

Poverty is one of the most pervasive risk factors underlying poor health, but is rarely targeted to improve health. Research on the effects of anti-poverty interventions on health has been limited, at least in part because funding for that research has been limited. Anti-poverty programs have been applied on a large scale, frequently by governments, but without systematic development and cumulative programmatic experimental studies. Anti-poverty programs that produce lasting effects on poverty have not been developed. Before evaluating the effect of anti-poverty programs on health, programs must be developed that can reduce poverty consistently. Anti-poverty programs require systematic development and cumulative programmatic scientific evaluation. Research on the therapeutic workplace could provide a model for that research and an adaptation of the therapeutic workplace could serve as a foundation of a comprehensive anti-poverty program. Once effective anti-poverty programs are developed, future research could determine if those programs improve health in addition to increasing income. The potential personal, health and economic benefits of effective anti-poverty programs could be substantial, and could justify the major efforts and expenses that would be required to support systematic research to develop such programs. Copyright © 2016 Elsevier Inc. All rights reserved.

Earth system dynamics: The interrelation of atmospheric, ocean and solid earth dynamics

NASA Technical Reports Server (NTRS)

Tapley, Byron D.; Asrar, Ghassem

1993-01-01

The research work performed during the time period 16 Oct. 1992 through 31 Dec. 1993 is summarized. The overall research activity, including a list of the major findings of the EOS IDS research to date, is described, the publications and presentations are listed, and a budget request for the subsequent year is attached. Specifically, the report covers: EOS panel activities; major findings of research; team member contributions; new research directions; EOS restructuring effect; changes in requirements; plans for using existing data; collaborations with other EOS and non-EOS investigations; EOS instrument team interaction; instrument development verification and validation; interaction with EOSDIS and DAAC's; team coordination; overall management; summary of response to site review questions and comments; science computing facility; and additional new research activities.

Clinician–Investigator Training and the Need to Pilot New Approaches to Recruiting and Retaining This Workforce

PubMed Central

Hall, Alison K.; Lund, P. Kay

2017-01-01

Clinician–investigators, also called physician–scientists, offer critical knowledge and perspectives that benefit research on basic science mechanisms, improved diagnostic and therapeutic approaches, population and outcomes medicine, health policy, and health services, yet few clinically trained health professionals pursue a research career. Sustaining this workforce requires attention to the unique challenges faced by investigators who must achieve clinical and research competence during training and their careers. These challenges include the duration of required clinical training, limited or discontinuous research opportunities, high levels of educational debt, balancing the dual obligations and rewards of clinical care and research, competition for research funding, and the need for leadership development after training. Women and individuals from underrepresented racial and ethnic groups comprise a small percentage of this workforce. The authors summarize the recent literature on training for clinician–investigators, emphasizing approaches with encouraging outcomes that warrant broader implementation. Using this overview as background, they convened three workshops at the National Institutes of Health in 2016 to identify and refine key priorities for potential new pilot programs to recruit and retain the clinician–investigator workforce. From these workshops emerged three priorities for future pilot programs: (1) support for research in residency, (2) new research on-ramps for health professionals at multiple career stages, and (3) national networks to diversify and sustain clinician–investigator faculty. Implementation of any pilot program will require coordinated commitment from academic health centers, medical licensing/certification boards, professional societies, and clinician–investigators themselves, in addition to support from the National Institutes of Health. PMID:28767499

Clinician-Investigator Training and the Need to Pilot New Approaches to Recruiting and Retaining This Workforce.

PubMed

Hall, Alison K; Mills, Sherry L; Lund, P Kay

2017-10-01

Clinician-investigators, also called physician-scientists, offer critical knowledge and perspectives that benefit research on basic science mechanisms, improved diagnostic and therapeutic approaches, population and outcomes medicine, health policy, and health services, yet few clinically trained health professionals pursue a research career. Sustaining this workforce requires attention to the unique challenges faced by investigators who must achieve clinical and research competence during training and their careers. These challenges include the duration of required clinical training, limited or discontinuous research opportunities, high levels of educational debt, balancing the dual obligations and rewards of clinical care and research, competition for research funding, and the need for leadership development after training. Women and individuals from underrepresented racial and ethnic groups comprise a small percentage of this workforce.The authors summarize the recent literature on training for clinician-investigators, emphasizing approaches with encouraging outcomes that warrant broader implementation. Using this overview as background, they convened three workshops at the National Institutes of Health in 2016 to identify and refine key priorities for potential new pilot programs to recruit and retain the clinician-investigator workforce. From these workshops emerged three priorities for future pilot programs: (1) support for research in residency, (2) new research on-ramps for health professionals at multiple career stages, and (3) national networks to diversify and sustain clinician-investigator faculty. Implementation of any pilot program will require coordinated commitment from academic health centers, medical licensing/certification boards, professional societies, and clinician-investigators themselves, in addition to support from the National Institutes of Health.

NATO Scientific and Technical Information Service (NSTIS): functional description. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Molholm, K.N.; Blados, W.N.; Bulca, C.

1987-08-01

This report provides a functional description of the requirements for a NATO Scientific and Technical Information Service (NSTIS). The user requirements and much of the background information in this report were derived primarily from interviews with more than 60 NATO Headquarters staff members between 2 March and 25 March 1987. In addition, representatives of the Supreme Headquarters Applied Powers Europe (SHAPE) Technical Centre (STC), the Supreme Allied Commander Atlantic (Anti-Submarine Warfare Research) Centre (SACLANTCEN), the NATO Communications and Information Systems Agency (NACISA), The Advisory Group for Aerospace Research and Development (AGARD), the U.S. Defense Technical Information Center (DTIC), and themore » Technical Documentation Center for the Armed Forces in the Netherlands (TDCK), were interviewed, either in person or by telephone.« less

A novel optic bistable device with very low threshold intensity using photorefractive films

NASA Astrophysics Data System (ADS)

Wang, Sean X.; Sun, Yuankun; Trivedi, Sudhir B.; Li, Guifang

1994-08-01

Brimrose Corporation of America reports the successful completion of the SBIR Phase I research in low-threshold intensity optical bistable devices using photorefractive nonlinearity. A thin photorefractive film optical bistable device was proposed in the Phase I proposal. The feasibility of this device was theoretically investigated. The theoretical feasibility study formulates the materials requirements in such a kind of configuration for Phase II research. In addition, we have proposed and investigated another configuration of optical bistable devices that do not require advanced photorefractive materials, namely, the self-pumped phase conjugator. We have successfully demonstrated a low-threshold optical bistable operation in a KNSBN:CU crystal. To the best of our knowledge, the threshold of 650 mW/sq. cm is the lowest of its kind to be achieved so far.

Value Streams in Microgrids: A literature Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Center for Energy and Innovative Technologies; Cardoso, Gonçalo

2015-10-01

Microgrids are an increasingly common component of the evolving electricity grids with the potential to improve local reliability, reduce costs, and increase penetration rates for distributed renewable generation. The additional complexity of microgrids often leads to increased investment costs, creating a barrier for widespread adoption. These costs may result directly from specific needs for islanding detection, protection systems and power quality assurance that would otherwise be avoided in simpler system configurations. However, microgrids also facilitate additional value streams that may make up for their increased costs and improve the economic viability of microgrid deployment. This paper analyses the literature currentlymore » available on research relevant to value streams occurring in microgrids that may contribute to offset the increased investment costs. A review on research related to specific microgrid requirements is also presented.« less

Greenhouses and their humanizing synergies

NASA Astrophysics Data System (ADS)

Haeuplik-Meusburger, Sandra; Paterson, Carrie; Schubert, Daniel; Zabel, Paul

2014-03-01

Greenhouses in space will require advanced technical systems of automatic watering, soil-less cultivation, artificial lighting, and computerized observation of plants. Functions discussed for plants in space habitats include physical/health requirements and human psychology, social cohesion, as well as the complex sensorial benefits of plants for humans. The authors consider the role of plants in long-term space missions historically since 1971 (Salyut 1) and propose a set of priorities to be considered within the design requirements for greenhouses and constructed environments given a range of benefits associated with plant-human relationships. They cite recent research into the use of greenhouses in extreme environments to reveal the relative importance of greenhouses for people living in isolated locations. Additionally, they put forward hypotheses about where greenhouses might factor into several strata of human health. In a recent design-in-use study of astronauts' experiences in space habitats discussed in Architecture for Astronauts (Springer Press 2011) it was found that besides the basic advantages for life support there are clearly additional "side benefits" for habitability and physical wellbeing, and thus long-term mission success. The authors have composed several key theses regarding the need to promote plant-human relationships in space, including areas where synergy and symbiosis occur. They cite new comprehensive research into the early US Space Program to reveal where programmatic requirements could be added to space architecture to increase the less quantifiable benefits to astronauts of art, recreation, and poetic engagement with their existential condition of estrangement from the planet. Specifically in terms of the technological requirements, the authors propose the integration of a new greenhouse subsystem component into space greenhouses—the Mobile Plant Cultivation Subsystem—a portable, personal greenhouse that can be integrated functionally into future greenhouse constructions in space.

Genetic Analysis of Reduced γ-Tocopherol Content in Ethiopian Mustard Seeds.

PubMed

García-Navarro, Elena; Fernández-Martínez, José M; Pérez-Vich, Begoña; Velasco, Leonardo

2016-01-01

Ethiopian mustard (Brassica carinata A. Braun) line BCT-6, with reduced γ-tocopherol content in the seeds, has been previously developed. The objective of this research was to conduct a genetic analysis of seed tocopherols in this line. BCT-6 was crossed with the conventional line C-101 and the F1, F2, and BC plant generations were analyzed. Generation mean analysis using individual scaling tests indicated that reduced γ-tocopherol content fitted an additive-dominant genetic model with predominance of additive effects and absence of epistatic interactions. This was confirmed through a joint scaling test and additional testing of the goodness of fit of the model. Conversely, epistatic interactions were identified for total tocopherol content. Estimation of the minimum number of genes suggested that both γ- and total tocopherol content may be controlled by two genes. A positive correlation between total tocopherol content and the proportion of γ-tocopherol was identified in the F2 generation. Additional research on the feasibility of developing germplasm with high tocopherol content and reduced concentration of γ-tocopherol is required.

Comparative Effectiveness Research in Oncology

PubMed Central

2013-01-01

Although randomized controlled trials represent the gold standard for comparative effective research (CER), a number of additional methods are available when randomized controlled trials are lacking or inconclusive because of the limitations of such trials. In addition to more relevant, efficient, and generalizable trials, there is a need for additional approaches utilizing rigorous methodology while fully recognizing their inherent limitations. CER is an important construct for defining and summarizing evidence on effectiveness and safety and comparing the value of competing strategies so that patients, providers, and policymakers can be offered appropriate recommendations for optimal patient care. Nevertheless, methodological as well as political and social challenges for CER remain. CER requires constant and sophisticated methodological oversight of study design and analysis similar to that required for randomized trials to reduce the potential for bias. At the same time, if appropriately conducted, CER offers an opportunity to identify the most effective and safe approach to patient care. Despite rising and unsustainable increases in health care costs, an even greater challenge to the implementation of CER arises from the social and political environment questioning the very motives and goals of CER. Oncologists and oncology professional societies are uniquely positioned to provide informed clinical and methodological expertise to steer the appropriate application of CER toward critical discussions related to health care costs, cost-effectiveness, and the comparative value of the available options for appropriate care of patients with cancer. PMID:23697601

Perspectives in marine science: A European point of view

NASA Astrophysics Data System (ADS)

Barthel, K.-G.

1995-03-01

Marine research has always been a field in science which was particularly open to, and at times dependent on, international cooperation, and this has become even more obvious during the last decade when issues of global change became central to any discussion. The global nature of scientific and other problems, required the development of new concepts and led to the establishment of new structures in research, coordination and funding on an international level. In Europe the 12 member European Community often served as a nucleus for larger networks and initiatives (e.g. COST, EUREKA), and in 1989 the EC itself launched a specific programme on marine research and technology (MAST). The various initiatives are not meant to replace, national efforts but to complement them — where added value arises from international cooperation, e.g. in global programmes like IGBP, WCRP and their various core projects. The focus of support for these programmes through international funding agencies and networks is not primarily on additional research money but more on structural support and coordination. In contrast, the MAST targeted projects on the North Atlantic margin and the Mediterranean also receive substantial basic support, and are designed to fill gaps left by other international research projects. Both EC and other projects profit from the coordinating measures offered by the EC Commission. A more efficient use of facilities (research vessels, special equipment) can be achieved by having central information services. Well-integrated international projects also require additional efforts in standardization of instrumentation, methods and units, with respect to sampling, sample processing and data treatment. Furthermore, the scope of the task to tackle questions of global change demands the development of new technologies like ROVs, biosensors, automatized sample and data acquisition and treatment, etc. Full exploitation of the results in scientific, political and economical terms is only facilitated through special concertation. Mathematical modelling of ecosystems is still in its infancy and needs further cooperative development in order to provide tools for forecasting and management. Finally, training and exchange of personnel on a European, and possibly wider, level needs to be intensified in order to meet the requirements of modern science.

Corrosion Evaluation of RERTR Uranium Molybdenum Fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

A K Wertsching

2012-09-01

As part of the National Nuclear Security Agency (NNSA) mandate to replace the use of highly enriched uranium (HEU) fuel for low enriched uranium (LEU) fuel, research into the development of LEU fuel for research reactors has been active since the late 1970’s. Originally referred to as the Reduced Enrichment for Research and Test Reactor (RERTR) program the new effort named Global Threat Reduction Initiative (GTRI) is nearing the goal of replacing the standard aluminum clad dispersion highly enriched uranium aluminide fuel with a new LEU fuel. The five domestic high performance research reactors undergoing this conversion are High Fluxmore » Isotope reactor (HFIR), Advanced Test Reactor (ATR), National Institute of Standards and Technology (NIST) Reactor, Missouri University Research Reactor (MURR) and the Massachusetts Institute of Technology Reactor II (MITR-II). The design of these reactors requires a higher neutron flux than other international research reactors, which to this point has posed unique challenges in the design and development of the new mandated LEU fuel. The new design utilizes a monolithic fuel configuration in order to obtain sufficient 235U within the LEU stoichoimetry to maintain the fission reaction within the domestic test reactors. The change from uranium aluminide dispersion fuel type to uranium molybdenum (UMo) monolithic configuration requires examination of possible corrosion issues associated with the new fuel meat. A focused analysis of the UMo fuel under potential corrosion conditions, within the ATR and under aqueous storage indicates a slow and predictable corrosion rate. Additional corrosion testing is recommended for the highest burn-up fuels to confirm observed corrosion rate trends. This corrosion analysis will focus only on the UMo fuel and will address corrosion of ancillary components such as cladding only in terms of how it affects the fuel. The calculations and corrosion scenarios are weighted with a conservative bias to provide additional confidence with the results. The actual corrosion rates of UMo fuel is very likely to be lower than assumed within this report which can be confirmed with additional testing.« less

The Reynolds Creek Experimental Watershed: A Hydro-Geo-Climatic Observatory for the 21^{st} Century

NASA Astrophysics Data System (ADS)

Marks, D.; Seyfried, M.; Flerchinger, G.

2006-12-01

Long-term hydro-climatic data on a watershed scale are critical to improving our understanding of basic hydrologic and ecologic processes because they provide a context to assess inter-annual variability and allow us to document longer-term trends. In addition, a scientific infrastructure that captures the spatial variations within a watershed are required to identify recharge areas, describe the amount and timing of streamflow generation and understand the variability of vegetation. These basic data, combined with soil microclimate information, are required to describe the milieu for geochemical weathering and soil formation. Data from watersheds that include significant human activities, such as grazing, farming, irrigation, and urbanization, represent conditions typical to most watersheds and are critical for determining the signature of human induced changes on hydrologic processes and the water cycle. The Reynolds Creek Experimental Watershed (RCEW), a 239 km2 drainage in the Owyhee Mountains near Boise, Idaho, was added to the USDA Agricultural Research Service watershed program in 1960. The vision for RCEW as an outdoor laboratory to support watershed research was described 1965 in the first volume of Water Resources Research [Robins et al., 1965]. The RCEW has supported a sustained data collection network for over 45 years. The first 35 years of data were presented in a series of papers in 2001 [Marks, 2001]. More recently, there has been an effort to better describe spatial variations within the watershed, and research is currently supported by 9 weirs, 32 primary and 5 secondary meteorological measurement stations, 26 precipitation stations, 8 snow course and 5 snow study sites, and 5 eddy covariance systems. In addition, soil microclimate (moisture and temperature) profile data are collected eight sites with surface data collected at an additional 19 sites. These support a wide range of experimental investigations including snow hydrology and physics, cold season hydrology, geophysics, water quality, model development and testing, water and carbon flux experiments, ecosystem processes, grazing effects, and mountain climate research. Active watershed manipulation allows fire ecology and hydrology, vegetation-climate inter-action, watershed restoration, grazing and wildlife management, and invasive plant research.

When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions

PubMed Central

Bradbury, Andrew R. M.; Trinklein, Nathan D.; Wilkinson, Ian C.; Tandon, Atul K.; Anderson, Stephen; Bladen, Catherine L.; Jones, Brittany; Aldred, Shelley Force; Bestagno, Marco; Burrone, Oscar; Maynard, Jennifer; Ferrara, Fortunato; Görnemann, Janina; Glanville, Jacob; Wolf, Philipp; Frenzel, Andre; Wong, Julin; Koh, Xin Yu; Eng, Hui-Yan; Lane, David; Lefranc, Marie-Paule; Clark, Mike

2018-01-01

ABSTRACT Monoclonal antibodies are commonly assumed to be monospecific, but anecdotal studies have reported genetic diversity in antibody heavy chain and light chain genes found within individual hybridomas. As the prevalence of such diversity has never been explored, we analyzed 185 random hybridomas, in a large multicenter dataset. The hybridomas analyzed were not biased towards those with cloning difficulties or known to have additional chains. Of the hybridomas we evaluated, 126 (68.1%) contained no additional productive chains, while the remaining 59 (31.9%) contained one or more additional productive heavy or light chains. The expression of additional chains degraded properties of the antibodies, including specificity, binding signal and/or signal-to-noise ratio, as determined by enzyme-linked immunosorbent assay and immunohistochemistry. The most abundant mRNA transcripts found in a hybridoma cell line did not necessarily encode the antibody chains providing the correct specificity. Consequently, when cloning antibody genes, functional validation of all possible VH and VL combinations is required to identify those with the highest affinity and lowest cross-reactivity. These findings, reflecting the current state of hybridomas used in research, reiterate the importance of using sequence-defined recombinant antibodies for research or diagnostic use. PMID:29485921

The Combustion Performance and Ingredient Ratio of Thermite

NASA Astrophysics Data System (ADS)

Jia, Shuan-zhu; Du, Shi-guo; Zhen, Jian-wei; Yang, Xin-hui

2017-12-01

Thermite was widely used because of its combustion properties and combustion products. However, due to the combustion heat, ignition performance, burning rate and the ratio of energy conversion of different components of thermite agent are very different. The requirements of the main realization in: (a) Its easy to ignite and not easy to extinguish; (b) Combustion and heat as much as possible High; (c) The burning speed should be appropriate. So the performance of these aspects is always being hot focus. In this paper, four aspects of the improve about combustion heat, ignition performance, burning rate and the ratio of energy conversion were analyzed through the aluminum alloy, the addition of aluminum, the addition of the third party, the change of the particle size and the compaction density. Finaly states the research direction in the future. The future of aluminum heat agent formula research focus will be: (a) A single aluminum heat agent the best proportion of the study; (b) The addition of different additives and additives (c) The exploration of alternatives that are more excellent performance will inevitably become a hot topic to improve the heat of combustion. Aluminum heat agent performance will be much superior, and the application will also be more extensive.

Big data collision: the internet of things, wearable devices and genomics in the study of neurological traits and disease.

PubMed

Talboom, Joshua S; Huentelman, Matthew J

2018-05-01

Advances in information technology (IT) hardware in the last decade have led to the advent of small connected devices broadly referred to as the Internet of Things (IoT). The IoT and its subcategory of wearable devices (wearables) both have the potential to greatly impact biomedical research. This focused review covers recent biomedical research using the IoT and wearables in the area of neurological traits and disease. In addition, a look into the future of biomedical research using IoT devices and wearables as well as some areas requiring further consideration by the field will be discussed.

Checkpoint repair for high-performance out-of-order execution machines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hwu, W.M.W.; Patt, Y.N.

Out-or-order execution and branch prediction are two mechanisms that can be used profitably in the design of supercomputers to increase performance. Proper exception handling and branch prediction miss handling in an out-of-order execution machine to require some kind of repair mechanism which can restore the machine to a known previous state. In this paper the authors present a class of repair mechanisms using the concept of checkpointing. The authors derive several properties of checkpoint repair mechanisms. In addition, they provide algorithms for performing checkpoint repair that incur little overhead in time and modest cost in hardware, which also require nomore » additional complexity or time for use with write-back cache memory systems than they do with write-through cache memory systems, contrary to statements made by previous researchers.« less

Proposed Model for Translational Research at a Teaching-Intensive College of Pharmacy.

PubMed

Ulrich, Erin; Grady, Sarah; Vonderhaar, Jacqueline; Ruplin, Andrew

2017-08-08

Many American colleges of pharmacy are small, private, teaching institutions. Faculty are required to maintain a research agenda, although the publication quota is less compared with their publicly funded college of pharmacy peers. Faculty at these smaller schools conduct research with very little internal or external funding. This tends to lead to smaller, less impactful research findings. Translational research is becoming popular for research faculty as it bridges theory to practice. The Knowledge-to-Action (KTA) framework presents the steps to conduct translational research. To apply and determine if the KTA framework would be able to produce practice-impactful research at an institution that does not depend on grant funding as part of faculty research agendas. An interdisciplinary team was formed with providers at the clinical faculty's practice site. As the team moved through the KTA steps, authors documented the roles of each team member. It was clear that many different types of teams were formed throughout the KTA process. These teams were then categorized according to the Interdisciplinary Teamwork System. The final result is a proposed model of types of teams and required member roles that are necessary within each KTA step for faculty to conduct practice-impactful research at a small, private, teaching institution without substantial grant funding awards. Applying the KTA framework, two impactful original research manuscripts were developed over two academic years. Furthermore, the practitioners at the clinical faculty member's site were very pleased with the ease of conducting research, as they were never required to take a lead role. In addition, both faculty members alternated lead and support role allowing for a decreased burden of workload while producing theory-driven research. The KTA framework can create a model for translational research and may be particularly beneficial to small teaching institutions to conduct impactful research. Copyright © 2017. Published by Elsevier Inc.

Meta-analysis in applied ecology.

PubMed

Stewart, Gavin

2010-02-23

This overview examines research synthesis in applied ecology and conservation. Vote counting and pooling unweighted averages are widespread despite the superiority of syntheses based on weighted combination of effects. Such analyses allow exploration of methodological uncertainty in addition to consistency of effects across species, space and time, but exploring heterogeneity remains controversial. Meta-analyses are required to generalize in ecology, and to inform evidence-based decision-making, but the more sophisticated statistical techniques and registers of research used in other disciplines must be employed in ecology to fully realize their benefits.

Overview of the Telescience Testbed Program

NASA Technical Reports Server (NTRS)

Rasmussen, Daryl N.; Mian, Arshad; Leiner, Barry M.

1991-01-01

The NASA's Telescience Testbed Program (TTP) conducted by the Ames Research Center is described with particular attention to the objectives, the approach used to achieve these objectives, and the expected benefits of the program. The goal of the TTP is to gain operational experience for the Space Station Freedom and the Earth Observing System programs, using ground testbeds, and to define the information and communication systems requirements for the development and operation of these programs. The results of TTP are expected to include the requirements for the remote coaching, command and control, monitoring and maintenance, payload design, and operations management. In addition, requirements for technologies such as workstations, software, video, automation, data management, and networking will be defined.

Choline: Clinical Nutrigenetic/Nutrigenomic Approaches for Identification of Functions and Dietary Requirements

PubMed Central

Zeisel, Steven H.

2013-01-01

Nutrigenetics/nutrigenomics (the study of the bidirectional interactions between genes and diet) is a rapidly developing field that is changing research and practice in human nutrition. Though eventually nutrition clinicians may be able to provide personalized nutrition recommendations, in the immediate future they are most likely to use this knowledge to improve dietary recommendations for populations. Currently, estimated average requirements are used to set dietary reference intakes because scientists cannot adequately identify subsets of the population that differ in requirement for a nutrient. Recommended intake levels must exceed the actual required intake for most of the population in order to assure that individuals with the highest requirement ingest adequate amounts of the nutrient. As a result, dietary reference intake levels often are set so high that diet guidelines suggest almost unattainable intakes of some foods. Once it is possible to identify common subgroups that differ in nutrient requirements using nutrigenetic/nutrigenomic profiling, targeted interventions and recommendations can be refined. In addition, when a large variance exists in response to a nutrient, statistical analyses often argue for a null effect. If responders could be differentiated from nonre-sponders based on nutrigenetic/nutrigenomic profiling, this statistical noise could be eliminated and the sensitivity of nutrition research greatly increased. PMID:20436254

Disaster preparedness in biocontainment animal research facilities: developing and implementing an incident response plan (IRP).

PubMed

Swearengen, James R; Vargas, Karen J; Tate, Mallory K; Linde, N S

2010-01-01

Preparing for the wide variety of disasters that can occur is challenging for any animal research facility, but the level of concern for human and animal health rises significantly when infectious agents and toxins are part of the scenario. Federal regulations provide detailed requirements for the development of an incident response plan (IRP) when select agents and toxins (SATs) are used. In addition to the usual issues associated with disaster planning, the IRP must address concerns associated with the potential theft, loss, or release of SATs that may affect both institutional personnel and the surrounding community. The level of detail in the IRP and the intensity of training should be appropriate for the level of risk involved. Regulations describe certain basic requirements but do not address the risks of SAT-exposed animals, which have been the subject of additional guidance to help implement regulatory requirements. A 2008 joint publication of the Centers for Disease Control and Prevention and the Animal and Plant Health Inspection Service describes scenarios in which SAT-exposed animals are handled in the same manner as the agent or toxin itself for the purpose of reporting a SAT theft, loss, or release. Events that resulted from the impact of Hurricane Ike at the University of Texas Medical Branch in Galveston provide a valuable opportunity to evaluate the effectiveness of the federal regulations and to build on lessons learned from this disaster. These lessons can help to supplement the regulatory requirements and improve the safety and security of handling both SATs and animals exposed to them during and after an emergency situation.

[Status and suggestions for adjuvant standard for Chinese materia medica processing in China].

PubMed

Yang, Chun-Yu; Cao, Hui; Wang, Xiao-Tao; Tu, Jia-Sheng; Qian, Zhong-Zhi; Yu, Zhi-Ling; Shang, Yue; Zhang, Bao-Xian

2017-04-01

In this paper, the status of adjuvant standard for Chinese materia medica processing in the Chinese Pharmacopoeia 2015 edition, the National Specification of Chinese Materia Medica Processing, and the 29 provincial specification of Chinese materia medica was summarized, and the the status including general requirements, specific requirements, and quality standard in the three grade official specifications was collected and analyzed according to the "medicine-adjuvant homology" and "food-adjuvant homology" features of adjuvants. This paper also introduced the research situation of adjuvant standard for Chinese materia medica processing in China; In addition, analyzed and discussed the problems existing in the standard system of adjuvant for Chinese materia medica processing, such as lack of general requirements, low level of standard, inconsistent standard references, and lack of research on the standard, and provided suggestions for the further establishment of the national standards system of adjuvant for Chinese materia medica processing. Copyright© by the Chinese Pharmaceutical Association.

The use of a personal digital assistant for wireless entry of data into a database via the Internet.

PubMed

Fowler, D L; Hogle, N J; Martini, F; Roh, M S

2002-01-01

Researchers typically record data on a worksheet and at some later time enter it into the database. Wireless data entry and retrieval using a personal digital assistant (PDA) at the site of patient contact can simplify this process and improve efficiency. A surgeon and a nurse coordinator provided the content for the database. The computer programmer created the database, placed the pages of the database on the PDA screen, and researched and installed security measures. Designing the database took 6 months. Meeting Health Insurance Portability and Accountability Act of 1996 (HIPAA) requirements for patient confidentiality, satisfying institutional Information Services requirements, and ensuring connectivity required an additional 8 months before the functional system was complete. It is now possible to achieve wireless entry and retrieval of data using a PDA. Potential advantages include collection and entry of data at the same time, easy entry of data from multiple sites, and retrieval of data at the patient's bedside.

Hypersonic transport aircraft

NASA Technical Reports Server (NTRS)

1987-01-01

A hypersonic transport aircraft design project was selected as a result of interactions with NASA Lewis Research Center personnel and fits the Presidential concept of the Orient Express. The Graduate Teaching Assistant (GTA) and an undergraduate student worked at the NASA Lewis Research Center during the 1986 summer conducting a literature survey, and relevant literature and useful software were collected. The computer software was implemented in the Computer Aided Design Laboratory of the Mechanical and Aerospace Engineering Department. In addition to the lectures by the three instructors, a series of guest lectures was conducted. The first of these lectures 'Anywhere in the World in Two Hours' was delivered by R. Luidens of NASA Lewis Center. In addition, videotaped copies of relevant seminars obtained from NASA Lewis were also featured. The first assignment was to individually research and develop the mission requirements and to discuss the findings with the class. The class in consultation with the instructors then developed a set of unified mission requirements. Then the class was divided into three design groups (1) Aerodynamics Group, (2) Propulsion Group, and (3) Structures and Thermal Analyses Group. The groups worked on their respective design areas and interacted with each other to finally come up with an integrated conceptual design. The three faculty members and the GTA acted as the resource persons for the three groups and aided in the integration of the individual group designs into the final design of a hypersonic aircraft.

Review of Batteryless Wireless Sensors Using Additively Manufactured Microwave Resonators.

PubMed

Memon, Muhammad Usman; Lim, Sungjoon

2017-09-09

The significant improvements observed in the field of bulk-production of printed microchip technologies in the past decade have allowed the fabrication of microchip printing on numerous materials including organic and flexible substrates. Printed sensors and electronics are of significant interest owing to the fast and low-cost fabrication techniques used in their fabrication. The increasing amount of research and deployment of specially printed electronic sensors in a number of applications demonstrates the immense attention paid by researchers to this topic in the pursuit of achieving wider-scale electronics on different dielectric materials. Although there are many traditional methods for fabricating radio frequency (RF) components, they are time-consuming, expensive, complicated, and require more power for operation than additive fabrication methods. This paper serves as a summary/review of improvements made to the additive printing technologies. The article focuses on three recently developed printing methods for the fabrication of wireless sensors operating at microwave frequencies. The fabrication methods discussed include inkjet printing, three-dimensional (3D) printing, and screen printing.

Review of Batteryless Wireless Sensors Using Additively Manufactured Microwave Resonators

PubMed Central

2017-01-01

The significant improvements observed in the field of bulk-production of printed microchip technologies in the past decade have allowed the fabrication of microchip printing on numerous materials including organic and flexible substrates. Printed sensors and electronics are of significant interest owing to the fast and low-cost fabrication techniques used in their fabrication. The increasing amount of research and deployment of specially printed electronic sensors in a number of applications demonstrates the immense attention paid by researchers to this topic in the pursuit of achieving wider-scale electronics on different dielectric materials. Although there are many traditional methods for fabricating radio frequency (RF) components, they are time-consuming, expensive, complicated, and require more power for operation than additive fabrication methods. This paper serves as a summary/review of improvements made to the additive printing technologies. The article focuses on three recently developed printing methods for the fabrication of wireless sensors operating at microwave frequencies. The fabrication methods discussed include inkjet printing, three-dimensional (3D) printing, and screen printing. PMID:28891947

Frequency of reporting on patient and public involvement (PPI) in research studies published in a general medical journal: a descriptive study.

PubMed

Price, Amy; Schroter, Sara; Snow, Rosamund; Hicks, Melissa; Harmston, Rebecca; Staniszewska, Sophie; Parker, Sam; Richards, Tessa

2018-03-23

While documented plans for patient and public involvement (PPI) in research are required in many grant applications, little is known about how frequently PPI occurs in practice. Low levels of reported PPI may mask actual activity due to limited PPI reporting requirements. This research analysed the frequency and types of reported PPI in the presence and absence of a journal requirement to include this information. A before and after comparison of PPI reported in research papers published in The BMJ before and 1 year after the introduction of a journal policy requiring authors to report if and how they involved patients and the public within their papers. Between 1 June 2013 and 31 May 2014, The BMJ published 189 research papers and 1 (0.5%) reported PPI activity. From 1 June 2015 to 31 May 2016, following the introduction of the policy, The BMJ published 152 research papers of which 16 (11%) reported PPI activity. Patients contributed to grant applications in addition to designing studies through to coauthorship and participation in study dissemination. Patient contributors were often not fully acknowledged; 6 of 17 (35%) papers acknowledged their contributions and 2 (12%) included them as coauthors. Infrequent reporting of PPI activity does not appear to be purely due to a failure of documentation. Reporting of PPI activity increased after the introduction of The BMJ 's policy, but activity both before and after was low and reporting was inconsistent in quality. Journals, funders and research institutions should collaborate to move us from the current situation where PPI is an optional extra to one where PPI is fully embedded in practice throughout the research process. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

WDS/DSA Certification - International collaboration for a trustworthy research data infrastructure

NASA Astrophysics Data System (ADS)

Mokrane, Mustapha; Hugo, Wim; Harrison, Sandy

2016-04-01

Today's research is international, transdisciplinary, and data-enabled, which requires scrupulous data stewardship, full and open access to data, and efficient collaboration and coordination. New expectations on researchers based on policies from governments and funders to share data fully, openly, and in a timely manner present significant challenges but are also opportunities to improve the quality and efficiency of research and its accountability to society. Researchers should be able to archive and disseminate data as required by many institutions or funders, and civil society to scrutinize datasets underlying public policies. Thus, the trustworthiness of data services must be verifiable. In addition, the need to integrate large and complex datasets across disciplines and domains with variable levels of maturity calls for greater coordination to achieve sufficient interoperability and sustainability. The World Data System (WDS) of the International Council for Science (ICSU) promotes long-term stewardship of, and universal and equitable access to, quality-assured scientific data and services across a range of disciplines in the natural and social sciences. WDS aims at coordinating and supporting trusted scientific data services for the provision, use, and preservation of relevant datasets to facilitate scientific research, in particular under the ICSU umbrella, while strengthening their links with the research community. WDS certifies its Members, holders and providers of data or data products, using internationally recognized standards. Certification of scientific data services is essential to ensure trustworthiness of the global research data infrastructure. It contributes to building a searchable, distributed, interoperable and sustainable research data infrastructure. Several certification standards have been developed over the last decade, such as the Network of Expertise in long-term Storage and Accessibility of Digital Resources in Germany (NESTOR) seal, German Institute for Standardization (DIN) standard 31644, Trustworthy Repositories Audit and Certification (TRAC) criteria and the International Organization for Standardization (ISO) standard 16363. In addition, the Data Seal of Approval (DSA) and WDS have set up core certification mechanisms for trusted digital repositories in 2009, which are increasingly recognized as de facto standards. While DSA emerged in Europe in the Humanities and Social Sciences, WDS started as an international initiative with historical roots in the Earth and Space Sciences. Their catalogues of requirements and review procedures are based on the same principles of openness, transparency. A unique feature of the DSA and WDS certification is that it strikes a balance between simplicity, robustness and the effort required to complete. A successful international cross-project collaboration was initiated between WDS and DSA under the umbrella of the Research Data Alliance (RDA), an international initiative started in 2013 to promote data interoperability which provided a useful and neutral forum. A joint working group was established in early 2014 to reconcile and simplify the array of certification options and improve and stimulate core certification for scientific data services. The outputs of this collaboration are a Catalogue of Common Requirements (https://goo.gl/LJZqDo) and a Catalogue of Common Procedures (https://goo.gl/vNR0q1) which will be implemented jointly by WDS and DSA.

46 CFR 15.525 - Additional manning requirements for tank vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Additional manning requirements for tank vessels. 15.525... MANNING REQUIREMENTS Manning Requirements; Inspected Vessels § 15.525 Additional manning requirements for tank vessels. Parts 31 and 35 of this chapter contain additional manning requirements applicable to...

[Memorandum - research funding of prevention].

PubMed

Walter, U; Gold, C; Hoffmann, W; Jahn, I; Töppich, J; Wildner, M; Dubben, S; Franze, M; John, J; Kliche, T; Lehmann, H; Naegele, G; Nöcker, G; Plaumann, M; Pott, E; Robra, B-P

2012-08-01

The memorandum of the research funding of prevention has been devised within the framework of the Prevention Research Funding Programme of the Federal Ministry of Education and Research. It consists not only of the obtained findings of the research-practice co-operation but also of recommendations for the implementation of prospective, innovational, effective, practice-oriented and sustainable research. The respective knowledge has been acquired from quantitative surveys on the experiences of scientists and practice partners within the prevention research funding project as well as from extensive qualitative methods of structured group evaluation. A participatory co-operation between research and practice based on mutual respect, trust and recognition is seen as mandatory for the further development of both prevention and health promotion research. Research and practice partners are required to engage in an ab initio collaboration starting from the conception phase, whereby it is advisable to encourage and fortify the communication between research, practice and funding partners by systematic surveillance in form of a meta-project. In addition, the inclusion of the target population from the outset and on a collaborative basis is considered as beneficial in order to ensure the practical application of the research findings. Furthermore, innovatory research designs which are able to provide a framework for internal flexibility, continuous re-assessment and adjustment are fundamental for the implementation of practice-oriented research. Moreover, a dynamic co-operation between different groups of interest not only depends on sharing responsibility but also on sufficient funding for both research and practice, which is particularly important for the transfer and communication of the attained findings. With regard to the evaluation of both effectiveness and sustainability of interventions, a research funding project is required which makes long-term results possible through the utilization of regulated monitoring and guarantees quality and continuous effectiveness. Furthermore, in order to stimulate progress within the basic theories of prevention and health promotion, it is also essential for a funding project to focus on elementary concepts. Additionally, for the efficient and sustainable development of health within a population it is advisable to apply both self-contained research and the involvement of primary prevention and health promotion to research projects concerning health, social affairs, education, work and environment. © Georg Thieme Verlag KG Stuttgart · New York.

Wastes as Aggregates, Binders or Additions in Mortars: Selecting Their Role Based on Characterization.

PubMed

Farinha, Catarina Brazão; de Brito, Jorge; Veiga, Rosário; Fernández, J M; Jiménez, J R; Esquinas, A R

2018-03-20

The production of waste has increased over the years and, lacking a recycle or recovery solution, it is forwarded to landfill. The incorporation of wastes in cement-based materials is a solution to reduce waste deposition. In this regard, some researchers have been studying the incorporation of wastes with different functions: aggregate, binder and addition. The incorporation of wastes should take advantage of their characteristics. It requires a judicious analysis of their particles. This research involves the analysis of seven industrial wastes: biomass ashes, glass fibre, reinforced polymer dust, sanitary ware, fluid catalytic cracking, acrylic fibre, textile fibre and glass fibre. The main characteristics and advantages of each waste are enunciated and the best type of introduction in mortars is discussed. The characterization of the wastes as particles is necessary to identify the most suitable incorporation in mortars. In this research, some wastes are studied with a view to their re-use or recycling in mortars. Thus, this research focuses on the chemical, physical and mechanical characterization of industrial wastes and identification of the potentially most advantageous type of incorporation.

Wastes as Aggregates, Binders or Additions in Mortars: Selecting Their Role Based on Characterization

PubMed Central

de Brito, Jorge; Veiga, Rosário

2018-01-01

The production of waste has increased over the years and, lacking a recycle or recovery solution, it is forwarded to landfill. The incorporation of wastes in cement-based materials is a solution to reduce waste deposition. In this regard, some researchers have been studying the incorporation of wastes with different functions: aggregate, binder and addition. The incorporation of wastes should take advantage of their characteristics. It requires a judicious analysis of their particles. This research involves the analysis of seven industrial wastes: biomass ashes, glass fibre, reinforced polymer dust, sanitary ware, fluid catalytic cracking, acrylic fibre, textile fibre and glass fibre. The main characteristics and advantages of each waste are enunciated and the best type of introduction in mortars is discussed. The characterization of the wastes as particles is necessary to identify the most suitable incorporation in mortars. In this research, some wastes are studied with a view to their re-use or recycling in mortars. Thus, this research focuses on the chemical, physical and mechanical characterization of industrial wastes and identification of the potentially most advantageous type of incorporation. PMID:29558418

Visual Search Performance in the Autism Spectrum II: The Radial Frequency Search Task with Additional Segmentation Cues

ERIC Educational Resources Information Center

Almeida, Renita A.; Dickinson, J. Edwin; Maybery, Murray T.; Badcock, Johanna C.; Badcock, David R.

2010-01-01

The Embedded Figures Test (EFT) requires detecting a shape within a complex background and individuals with autism or high Autism-spectrum Quotient (AQ) scores are faster and more accurate on this task than controls. This research aimed to uncover the visual processes producing this difference. Previously we developed a search task using radial…

Manned Orbital Transfer Vehicle (MOTV). Volume 6: Five year program plan

NASA Technical Reports Server (NTRS)

Boyland, R. E.; Sherman, S. W.; Morfin, H. W.

1979-01-01

The five year program plan for the manned orbit transfer vehicle (MOTV) is presented. The planning, schedules, cost estimates, and supporting data (objectives, constraints, assumptions, etc.) associated with the development of the MOTV are discussed. The plan, in addition to the above material, identifies the supporting research and technology required to resolve issues critical to MOTV development.

Homemade Powerpoint Games: Game Design Pedagogy Aligned to the TPACK Framework

ERIC Educational Resources Information Center

Siko, Jason P.; Barbour, Michael K.

2012-01-01

While researchers are examining the role of playing games to learn, others are looking at using game design as an instructional tool. However, game-design software may require additional time to train both teachers and students. In this article, the authors discuss the use of Microsoft PowerPoint as a tool for game-design instruction and the…

Research on Nitride Thin Films, Advanced Plasma Diagnostics, and Charged-Particle Processes

DTIC Science & Technology

2006-07-01

Additionally, these components are being placed closer to the point of use--requiring that they operate in extreme temperature environments ...reasons for component failure. To operate in extreme temperature environments , electronic and electrical components must withstand higher ambient...hybrid and plug-in hybrid-powered automobiles, heart defibrillators , and industrial equipment will benefit from a new generation of capacitors. High

The Slippery Slope of Air Force Downsizing: A Strategy Connection

DTIC Science & Technology

2013-02-14

as the reductions continue. As an example, commanders and their Airmen are responsible for being administration, personnel, finance, communciations ... computer efficient because the expertise in their units or base has been reduced, eliminated or consolidated. This impacts the time and resources...are the areas that require additional research. • Issue: Other functional issues (Logistics, Finance, Contracting, Communications/ computers , Nuclear

Teacher Education That Promotes Educational Excellence: How to Know It When You See It.

ERIC Educational Resources Information Center

Hawley, Willis D.

Few positive comments about the way the nation prepares its teachers have been made. Many teacher education programs are in disarray due to inept staff and curricula that have not kept up with research results. In addition, many state agencies have set teacher certification requirements that are political in nature. From current analyses of…

Evidence-Based Ethics for Neurology and Psychiatry Research

PubMed Central

Kim, Scott Y. H.

2004-01-01

Summary: American bioethics, historically arising out of theology and philosophy, has been dominated by the method of normative analysis. Ethics as policy, however, requires in addition a solid evidence base. This paper discusses the background conditions that make neurotherapeutics research particularly challenging. Three key ethical issues are discussed within an evidence-based ethics framework: the ethical challenges arising from changes in the financial incentive structures for academic researchers and their institutions, the challenges of risk-benefit analysis for neurotherapeutics protocols testing innovative interventions, and the evolving issues surrounding impaired decision-making capacity and surrogate consent for research. For each of these issues, selected empirical data are reviewed, areas for further inquiry are noted, and the need for development of novel methods for bioethics policy research is discussed. PMID:15717040

NASA-Ames workload research program

NASA Technical Reports Server (NTRS)

Hart, Sandra

1988-01-01

Research has been underway for several years to develop valid and reliable measures and predictors of workload as a function of operator state, task requirements, and system resources. Although the initial focus of this research was on aeronautics, the underlying principles and methodologies are equally applicable to space, and provide a set of tools that NASA and its contractors can use to evaluate design alternatives from the perspective of the astronauts. Objectives and approach of the research program are described, as well as the resources used in conducting research and the conceptual framework around which the program evolved. Next, standardized tasks are described, in addition to predictive models and assessment techniques and their application to the space program. Finally, some of the operational applications of these tasks and measures are reviewed.

A Framework for Enhancing the Value of Research for Dissemination and Implementation

PubMed Central

Glasgow, Russell E.; Carpenter, Christopher R.; Grimshaw, Jeremy M.; Rabin, Borsika A.; Fernandez, Maria E.; Brownson, Ross C.

2015-01-01

A comprehensive guide that identifies critical evaluation and reporting elements necessary to move research into practice is needed. We propose a framework that highlights the domains required to enhance the value of dissemination and implementation research for end users. We emphasize the importance of transparent reporting on the planning phase of research in addition to delivery, evaluation, and long-term outcomes. We highlight key topics for which well-established reporting and assessment tools are underused (e.g., cost of intervention, implementation strategy, adoption) and where such tools are inadequate or lacking (e.g., context, sustainability, evolution) within the context of existing reporting guidelines. Consistent evaluation of and reporting on these issues with standardized approaches would enhance the value of research for practitioners and decision-makers. PMID:25393182

The influence of anthropometrics on physical employment standard performance.

PubMed

Reilly, T; Spivock, M; Prayal-Brown, A; Stockbrugger, B; Blacklock, R

2016-10-01

The Canadian Armed Forces (CAF) recently implemented the Fitness for Operational Requirements of CAF Employment (FORCE), a new physical employment standard (PES). Data collection throughout development included anthropometric profiles of the CAF. To determine if anthropometric measurements and demographic information would predict the performance outcomes of the FORCE and/or Common Military Task Fitness Evaluation (CMTFE). We conducted a secondary analysis of data from FORCE research. We obtained bioelectrical impedance and segmental analysis. Statistical analysis included correlation and linear regression analyses. Among the 668 study subjects, as predicted, any task requiring lifting, pulling or moving of an object was significantly and positively correlated (r > 0.67) to lean body mass (LBM) measurements. LBM correlated with stretcher carry (r = 0.78) and with lifting actions such as sand bag drag (r = 0.77), vehicle extrication (r = 0.71), sand bag fortification (r = 0.68) and sand bag lift time (r = -0.67). The difference between the correlation of dead mass (DM) with task performance compared with LBM was not statistically significant. DM and LBM can be used in a PES to predict success on military tasks such as casualty evacuation and manual material handling. However, there is no minimum LBM required to perform these tasks successfully. These data direct future research on how we should diversify research participants by anthropometrics, in addition to the traditional demographic variables of gender and age, to highlight potential important adverse impact with PES design. In addition, the results can be used to develop better training regimens to facilitate passing a PES. © All rights reserved. ‘The Influence of Anthropometrics on Physical Employment Standard Performance’ has been reproduced with the permission of DND, 2016.

Engineering Software Suite Validates System Design

NASA Technical Reports Server (NTRS)

2007-01-01

EDAptive Computing Inc.'s (ECI) EDAstar engineering software tool suite, created to capture and validate system design requirements, was significantly funded by NASA's Ames Research Center through five Small Business Innovation Research (SBIR) contracts. These programs specifically developed Syscape, used to capture executable specifications of multi-disciplinary systems, and VectorGen, used to automatically generate tests to ensure system implementations meet specifications. According to the company, the VectorGen tests considerably reduce the time and effort required to validate implementation of components, thereby ensuring their safe and reliable operation. EDASHIELD, an additional product offering from ECI, can be used to diagnose, predict, and correct errors after a system has been deployed using EDASTAR -created models. Initial commercialization for EDASTAR included application by a large prime contractor in a military setting, and customers include various branches within the U.S. Department of Defense, industry giants like the Lockheed Martin Corporation, Science Applications International Corporation, and Ball Aerospace and Technologies Corporation, as well as NASA's Langley and Glenn Research Centers

Physician to investigator: clinical practice to clinical research--ethical, operational, and financial considerations.

PubMed

Pierre, Christine

2008-01-01

Physicians who participate in clinical research studies gain benefits for themselves, their practice, and their patients. Historically, private practice physicians have chosen to defer to their counterparts in academic medicine when it comes to contributing to scientific advancement through clinical studies. A growing number of private practice physicians are now taking a serious second look and deciding that there are unique benefits for both the practice and the patient. Physicians who decide to participate in clinical research should give serious consideration to the time and resources that are required to meet both federal regulations and industry standards. In addition, ethical and scientific principles for assuring the protection of human research subjects must be a paramount commitment.

Large-Scale 3D Printing: The Way Forward

NASA Astrophysics Data System (ADS)

Jassmi, Hamad Al; Najjar, Fady Al; Ismail Mourad, Abdel-Hamid

2018-03-01

Research on small-scale 3D printing has rapidly evolved, where numerous industrial products have been tested and successfully applied. Nonetheless, research on large-scale 3D printing, directed to large-scale applications such as construction and automotive manufacturing, yet demands a great a great deal of efforts. Large-scale 3D printing is considered an interdisciplinary topic and requires establishing a blended knowledge base from numerous research fields including structural engineering, materials science, mechatronics, software engineering, artificial intelligence and architectural engineering. This review article summarizes key topics of relevance to new research trends on large-scale 3D printing, particularly pertaining (1) technological solutions of additive construction (i.e. the 3D printers themselves), (2) materials science challenges, and (3) new design opportunities.

Golden Rice--five years on the road--five years to go?

PubMed

Al-Babili, Salim; Beyer, Peter

2005-12-01

Provitamin A accumulates in the grain of Golden Rice as a result of genetic transformation. In developing countries, where vitamin A deficiency prevails, grain from Golden Rice is expected to provide this important micronutrient sustainably through agriculture. Since its original production, the prototype Golden Rice has undergone intense research to increase the provitamin A content, to establish the scientific basis for its carotenoid complement, and to better comply with regulatory requirements. Today, the current focus is on how to get Golden Rice effectively into the hands of farmers, which is a novel avenue for public sector research, carried out with the aid of international research consortia. Additional new research is underway to further increase the nutritional value of Golden Rice.

Microgravity research in the era of Space Station Freedom

NASA Technical Reports Server (NTRS)

Lee, Mark C.

1989-01-01

NASA has developed numerous microgravity research-related missions planned for the period of 1991 to 1994, leading to Space Station Freedom (SSF). Space Transportation System (STS) flights are designed with the philosophy that STS, Spacelab, and SSF will constitute an integrated system allowing an evolutionary approach to microgravity research in low earth orbit. Ground experiments, tested and refined on short-duration STS flights, will be developed and deployed on SSF where long-duration operation is required. In addition, this sequence will ensure maximum scientific return, encourage growth of the research community, and increase the chances of identifying new techniques and processes to be used in the SSF time frame. The paper discusses the rationale, justification, and approach taken by NASA to fully exploit this environment.

Closing the gap between knowledge and clinical application: challenges for genomic translation.

PubMed

Burke, Wylie; Korngiebel, Diane M

2015-01-01

Despite early predictions and rapid progress in research, the introduction of personal genomics into clinical practice has been slow. Several factors contribute to this translational gap between knowledge and clinical application. The evidence available to support genetic test use is often limited, and implementation of new testing programs can be challenging. In addition, the heterogeneity of genomic risk information points to the need for strategies to select and deliver the information most appropriate for particular clinical needs. Accomplishing these tasks also requires recognition that some expectations for personal genomics are unrealistic, notably expectations concerning the clinical utility of genomic risk assessment for common complex diseases. Efforts are needed to improve the body of evidence addressing clinical outcomes for genomics, apply implementation science to personal genomics, and develop realistic goals for genomic risk assessment. In addition, translational research should emphasize the broader benefits of genomic knowledge, including applications of genomic research that provide clinical benefit outside the context of personal genomic risk.

Defining Attributes and Metrics of Effective Research Mentoring Relationships.

PubMed

Pfund, Christine; Byars-Winston, Angela; Branchaw, Janet; Hurtado, Sylvia; Eagan, Kevin

2016-09-01

Despite evidence of mentoring's importance in training researchers, studies to date have not yet determined which mentoring relationships have the most impact and what specific factors in those mentoring relationships contribute to key outcomes, such as the commitment to and persistence in research career paths for emerging researchers from diverse populations. Efforts to broaden participation and persistence in biomedical research careers require an understanding of why and how mentoring relationships work and their impact, not only to research training but also to promoting career advancement. This paper proposes core attributes of effective mentoring relationships, as supported by the literature and suggested by theoretical models of academic persistence. In addition, both existing and developing metrics for measuring the effectiveness of these attributes within mentoring relationships across diverse groups are presented, as well as preliminary data on these metrics from the authors' work.

A model for evaluating academic research centers: Case study of the Asian/Pacific Islander Youth Violence Prevention Center.

PubMed

Nishimura, Stephanie T; Hishinuma, Earl S; Goebert, Deborah A; Onoye, Jane M M; Sugimoto-Matsuda, Jeanelle J

2018-02-01

To provide one model for evaluating academic research centers, given their vital role in addressing public health issues. A theoretical framework is described for a comprehensive evaluation plan for research centers. This framework is applied to one specific center by describing the center's Logic Model and Evaluation Plan, including a sample of the center's activities. Formative and summative evaluation information is summarized. In addition, a summary of outcomes is provided: improved practice and policy; reduction of risk factors and increase in protective factors; reduction of interpersonal youth violence in the community; and national prototype for prevention of interpersonal youth violence. Research centers are important mechanisms to advance science and improve people's quality of life. Because of their more infrastructure-intensive and comprehensive approach, they also require substantial resources for success, and thus, also require careful accountability. It is therefore important to comprehensively evaluate these centers. As provided herein, a more systematic and structured approach utilizing logic models, an evaluation plan, and successful processes can provide research centers with a functionally useful method in their evaluation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Predicting Space Weather: Challenges for Research and Operations

NASA Astrophysics Data System (ADS)

Singer, H. J.; Onsager, T. G.; Rutledge, R.; Viereck, R. A.; Kunches, J.

2013-12-01

Society's growing dependence on technologies and infrastructure susceptible to the consequences of space weather has given rise to increased attention at the highest levels of government as well as inspired the need for both research and improved space weather services. In part, for these reasons, the number one goal of the recent National Research Council report on a Decadal Strategy for Solar and Space Physics is to 'Determine the origins of the Sun's activity and predict the variations in the space environment.' Prediction of conditions in our space environment is clearly a challenge for both research and operations, and we require the near-term development and validation of models that have sufficient accuracy and lead time to be useful to those impacted by space weather. In this presentation, we will provide new scientific results of space weather conditions that have challenged space weather forecasters, and identify specific areas of research that can lead to improved capabilities. In addition, we will examine examples of customer impacts and requirements as well as the challenges to the operations community to establish metrics that enable the selection and transition of models and observations that can provide the greatest economic and societal benefit.

Army requirements for micro and nanotechnology-based sensors in weapons health and battlefield environmental monitoring applications

NASA Astrophysics Data System (ADS)

Ruffin, Paul; Brantley, Christina; Edwards, Eugene; Hutcheson, Guilford

2006-03-01

The Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC) and the Army Research Laboratory (ARL) have initiated a joint advanced technology demonstration program entitled "Prognostics/Diagnostics for the Future Force (PDFF)" with a key objective of developing low or no power embedded sensor suites for harsh environmental monitoring. The most critical challenge of the program is to specify requirements for the embedded sensor suites which will perform on-board diagnostics, maintain a history of sensor data, and forecast weapon health. The authors are currently collaborating with the PDFF program managers and potential customers to quantify the requirements for remotely operated, micro/nano-technology-based sensors for a host of candidate weapon systems. After requirements are finalized, current micro/nanotechnology-based temperature, humidity, g-shock, vibration and chemical sensors for monitoring the out-gassing of weapons propellant, as well as hazardous gaseous species on the battlefield and in urban environments will be improved to meet the full requirements of the PDFF program. In this paper, performance requirements such as power consumption, reliability, maintainability, survivability, size, and cost, along with the associated technical challenges for micro/nanotechnology-based sensor systems operating in military environments, are discussed. In addition, laboratory results from the design and testing of a wireless sensor array, which was developed using a thin film of functionalized carbon nanotube materials, are presented. Conclusions from the research indicate that the detection of bio-hazardous materials is possible using passive and active wireless sensors based on monitoring the reflected phase from the sensor.

Ethnic disparities in the dietary requirement for vitamin D during pregnancy: considerations for nutrition policy and research.

PubMed

O'Callaghan, Karen M; Kiely, Mairead E

2018-05-01

Despite the inverse association between skin colour and efficiency of cutaneous vitamin D synthesis, in addition to the widely accepted racial disparity in vitamin D status, populations of ethnic minority are understudied in terms of setting target serum 25-hydroxyvitamin D concentrations and corresponding dietary requirements for vitamin D. In minority groups, prevention of vitamin D deficiency on a population basis is challenging due to the lack of clarity surrounding the metabolism and transport of vitamin D. Authoritative agencies have been unable to define pregnancy-specific dietary recommendations for vitamin D, owing to an absence of sufficient evidence to confirm whether nutritional requirements for vitamin D are altered during pregnancy. While the question of setting race- and pregnancy-specific dietary reference values for vitamin D has not been addressed to date, endemic vitamin D deficiency has been reported among gravidae worldwide, specifically among ethnic minorities and white women resident at high latitude. In light of the increased risk of nutritional rickets among infants of ethnic minority, coupled with growing evidence for potential non-skeletal roles of vitamin D in perinatal health, determination of the dietary vitamin D requirement that will prevent deficiency during pregnancy is a research priority. However, systematic approaches to establishing dietary requirements are limited by the quality of the available evidence and the under-representation of minority groups in clinical research. This review considers the evidence for racial differences in vitamin D status and response to vitamin D supplementation, with particular application to pregnancy-specific requirements among ethnic minorities resident at high latitudes.

Development of high capacity, high rate lithium ion batteries utilizing metal fiber conductive additives

NASA Astrophysics Data System (ADS)

Ahn, Soonho; Kim, Youngduk; Kim, Kyung Joon; Kim, Tae Hyung; Lee, Hyungkeun; Kim, Myung H.

As lithium ion cells dominate the battery market, the performance improvement is an utmost concern among developers and researchers. Conductive additives are routinely employed to enhance electrode conductivity and capacity. Carbon particulates—graphite or carbon black powders—are conventional and popular choices as conductive fillers. However, percolation requirements of particles demand significant volumetric content of impalpable, and thereby high area conductive fillers. As might be expected, the electrode active surface area escalates unnecessarily, resulting in overall increase in reaction with electrolytes and organic solvents. The increased reactions usually manifest as an irreversible loss of anode capacity, gradual oxidation and consumption of electrolyte on the cathode—which causes capacity decline during cycling—and an increased threat to battery safety by gas evolution and exothermic solvent oxidation. In this work we have utilized high aspect ratio, flexible, micronic metal fibers as low active area and high conductivity additives. The metal fibers appear well dispersed within the electrode and to satisfy percolation requirements very efficiently at very low volumetric content compared to conventional carbon-based conductive additives. Results from 18650-type cells indicate significant enhancements in electrode capacity and high rate capability while the irreversible capacity loss is negligible.

Stakeholder views on returning research results.

PubMed

Haga, Susanne B; Zhao, Jennifer Q

2013-01-01

While the disclosure of research findings is relevant to all types of biomedical research, it has garnered particular attention with respect to genetics and genomics research due to some of the unique aspects of the data and the high public profile of the field. In this chapter, we review the attitudes of stakeholders (research participants, policymakers, and researchers) to define areas of consensus regarding the issue of returning research results across and within groups. In addition to stakeholder attitudes about obligations and interest in research results, other major related issues related to returning research results, such as informed consent, communication of research results, and cost, are discussed. Given the consensus between stakeholders to return summary reports of a study's outcomes and individual research results of clinical significance, we conclude that the time has come to encourage, if not require, researchers to consider these issues in the developmental planning stages of a project and to plan and budget accordingly. © 2013 Elsevier Inc. All rights reserved.

Collaborative partnership and the social value of clinical research: a qualitative secondary analysis.

PubMed

Nurmi, Sanna-Maria; Halkoaho, Arja; Kangasniemi, Mari; Pietilä, Anna-Maija

2017-10-25

Protecting human subjects from being exploited is one of the main ethical challenges for clinical research. However, there is also a responsibility to protect and respect the communities who are hosting the research. Recently, attention has focused on the most efficient way of carrying out clinical research, so that it benefits society by providing valuable research while simultaneously protecting and respecting the human subjects and the communities where the research is conducted. Collaboration between partners plays an important role and that is why we carried out a study to describe how collaborative partnership and social value are emerging in clinical research. A supra-analysis design for qualitative descriptive secondary analysis was employed to consider a novel research question that pertained to nurse leaders' perceptions of ethical recruitment in clinical research and the ethics-related aspects of clinical research from the perspective of administrative staff. The data consisted of two separate pre-existing datasets, comprising 451 pages from 41 interviews, and we considered the research question by using deductive-inductive content analysis with NVivo software. A deductive analysis matrix was generated on the basis of two requirements, namely collaborative partnership and social value, as presented in An Ethical Framework for Biomedical Research by Emanuel et al. The findings showed that collaborative partnership was a cornerstone for ethical clinical research and ways to foster inter-partner collaboration were indicated, such as supporting mutual respect and equality, shared goals and clearly defined roles and responsibilities. In addition, the social value of clinical research was an important precondition for ethical clinical research and its realisation required the research partners to demonstrate collaboration and shared responsibility during the research process. However, concerns emerged that the multidimensional meaning of clinical research for society was not fully recognised. Achieving greater social value for clinical research required greater transparency, setting research priorities, shared responsibility for the dissemination and use of the findings and stronger community awareness of the ethics-related aspects of clinical research. Collaborative partnership and social values are essential for protecting the human subjects and communities involved in clinical research.

An Update on the NASA Planetary Science Division Research and Analysis Program

NASA Astrophysics Data System (ADS)

Richey, Christina; Bernstein, Max; Rall, Jonathan

2015-01-01

Introduction: NASA's Planetary Science Division (PSD) solicits its Research and Analysis (R&A) programs each year in Research Opportunities in Space and Earth Sciences (ROSES). Beginning with the 2014 ROSES solicitation, PSD will be changing the structure of the program elements under which the majority of planetary science R&A is done. Major changes include the creation of five core research program elements aligned with PSD's strategic science questions, the introduction of several new R&A opportunities, new submission requirements, and a new timeline for proposal submissionROSES and NSPIRES: ROSES contains the research announcements for all of SMD. Submission of ROSES proposals is done electronically via NSPIRES: http://nspires.nasaprs.com. We will present further details on the proposal submission process to help guide younger scientists. Statistical trends, including the average award size within the PSD programs, selections rates, and lessons learned, will be presented. Information on new programs will also be presented, if available.Review Process and Volunteering: The SARA website (http://sara.nasa.gov) contains information on all ROSES solicitations. There is an email address (SARA@nasa.gov) for inquiries and an area for volunteer reviewers to sign up. The peer review process is based on Scientific/Technical Merit, Relevance, and Level of Effort, and will be detailed within this presentation.ROSES 2014 submission changes: All PSD programs will use a two-step proposal submission process. A Step-1 proposal is required and must be submitted electronically by the Step-1 due date. The Step-1 proposal should include a description of the science goals and objectives to be addressed by the proposal, a brief description of the methodology to be used to address the science goals and objectives, and the relevance of the proposed research to the call submitted to.Additional Information: Additional details will be provided on the Cassini Data Analysis Program, the Exoplanets Research program and Discovery Data Analysis Program, for which Dr. Richey is the Lead Program Officer.

Inverse halftoning via robust nonlinear filtering

NASA Astrophysics Data System (ADS)

Shen, Mei-Yin; Kuo, C.-C. Jay

1999-10-01

A new blind inverse halftoning algorithm based on a nonlinear filtering technique of low computational complexity and low memory requirement is proposed in this research. It is called blind since we do not require the knowledge of the halftone kernel. The proposed scheme performs nonlinear filtering in conjunction with edge enhancement to improve the quality of an inverse halftoned image. Distinct features of the proposed approach include: efficiently smoothing halftone patterns in large homogeneous areas, additional edge enhancement capability to recover the edge quality and an excellent PSNR performance with only local integer operations and a small memory buffer.

Proceedings of the Air Transportation Management Workshop

NASA Technical Reports Server (NTRS)

Tobias, Leonard (Editor); Tashker, Michael G. (Editor); Boyle, Angela M. (Editor)

1995-01-01

The Air Transportation Management (ATM) Workshop was held 31 Jan. - 1 Feb. 1995 at NASA Ames Research Center. The purpose of the workshop was to develop an initial understanding of user concerns and requirements for future ATM capabilities and to initiate discussions of alternative means and technologies for achieving more effective ATM capabilities. The topics for the sessions were as follows: viewpoints of future ATM capabilities, user requirements, lessons learned, and technologies for ATM. In addition, two panel sessions discussed priorities for ATM, and potential contributions of NASA to ATM. The proceedings contain transcriptions of all sessions.

Using Interactive Patient Engagement Technology in Clinical Practice: A Qualitative Assessment of Nurses' Perceptions.

PubMed

Patmon, Frances L; Gee, Perry M; Rylee, Tina L; Readdy, Noriann L

2016-11-11

Research has shown patients who are more engaged in their care are likely to have better health outcomes and reduced health care costs. Health care organizations are now focusing their efforts in finding ways to improve patient engagement. At the forefront of this movement are patient engagement technology systems. In this paper, these emerging systems are described as interactive patient engagement technologies (iPET). The objective of this descriptive study was to gain an understanding of the perceptions of nurses who are integrating these iPET systems into their daily clinical practice. The research team interviewed 38 nurses from 2 California-based hospitals using a focused rapid ethnographic evaluation methodology to gather data. The study participants reported that using iPET systems may enhance clinical nursing practice. The 4 key findings of iPET were that it (1) is effective for distraction therapy, (2) has functionality that affects both patients and nurses, (3) has implications for clinical practice, and (4) may require additional training to improve usage. With sufficient training on the iPET system, nurses believed they could use these technologies as an enhancement to their clinical practice. Additionally, nurses perceived these systems served as distraction therapy for patients. Initial findings suggest that iPET is beneficial, but more research is required to examine the usefulness of iPET systems in the inpatient settings. ©Frances L Patmon, Perry M Gee, Tina L Rylee, Noriann L Readdy. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 11.11.2016.

NREL Software Aids Offshore Wind Turbine Designs (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2013-10-01

NREL researchers are supporting offshore wind power development with computer models that allow detailed analyses of both fixed and floating offshore wind turbines. While existing computer-aided engineering (CAE) models can simulate the conditions and stresses that a land-based wind turbine experiences over its lifetime, offshore turbines require the additional considerations of variations in water depth, soil type, and wind and wave severity, which also necessitate the use of a variety of support-structure types. NREL's core wind CAE tool, FAST, models the additional effects of incident waves, sea currents, and the foundation dynamics of the support structures.

HF propagation factors affecting the design and operation of real time, channel evaluation, adaptive systems

NASA Astrophysics Data System (ADS)

Aarons, J.; Grossi, M. D.

1982-08-01

To develop and operate an adaptive system, propagation factors of the ionospheric medium must be given to the designer. The operation of the system must change as a function of multipath spread, Doppler spread, path losses, channel correlation functions, etc. In addition, NATO mid-latitude HF transmission and transauroral paths require varying system operation, which must fully utilize automatic path diversity across transauroral paths. Current research and literature are reviewed to estimate the extent of the available technical information. Additional investigations to allow designers to orient new systems on realistic models of these parameters are suggested.

Toolbox for Research, or how to facilitate a central data management in small-scale research projects.

PubMed

Bialke, Martin; Rau, Henriette; Thamm, Oliver C; Schuldt, Ronny; Penndorf, Peter; Blumentritt, Arne; Gött, Robert; Piegsa, Jens; Bahls, Thomas; Hoffmann, Wolfgang

2018-01-25

In most research projects budget, staff and IT infrastructures are limiting resources. Especially for small-scale registries and cohort studies professional IT support and commercial electronic data capture systems are too expensive. Consequently, these projects use simple local approaches (e.g. Excel) for data capture instead of a central data management including web-based data capture and proper research databases. This leads to manual processes to merge, analyze and, if possible, pseudonymize research data of different study sites. To support multi-site data capture, storage and analyses in small-scall research projects, corresponding requirements were analyzed within the MOSAIC project. Based on the identified requirements, the Toolbox for Research was developed as a flexible software solution for various research scenarios. Additionally, the Toolbox facilitates data integration of research data as well as metadata by performing necessary procedures automatically. Also, Toolbox modules allow the integration of device data. Moreover, separation of personally identifiable information and medical data by using only pseudonyms for storing medical data ensures the compliance to data protection regulations. This pseudonymized data can then be exported in SPSS format in order to enable scientists to prepare reports and analyses. The Toolbox for Research was successfully piloted in the German Burn Registry in 2016 facilitating the documentation of 4350 burn cases at 54 study sites. The Toolbox for Research can be downloaded free of charge from the project website and automatically installed due to the use of Docker technology.

Ethical aspects in tissue research: thematic analysis of ethical statements to the research ethics committee

PubMed Central

2012-01-01

Background Many studies have been published about ethics committees and the clarifications requested about the submitted applications. In Finland, ethics committees require a separate statement on ethical aspects of the research in applications to the ethics committee. However, little is known about how researchers consider the ethical aspects of their own studies. Methods The data were collected from all the applications received by the official regional ethics committee in the Hospital District of Northern Savo during 2004–2009 (n = 688). These included a total of 56 studies involving research on tissue other than blood. The statements by the researchers about the ethics about their own research in these applications were analyzed by thematic content analysis under the following themes: recruitment, informed consent, risks and benefits, confidentiality and societal meaning. Results The researchers tended to describe recruitment and informed consent process very briefly. Usually these descriptions simply stated who the recruiter was and that written consent would be required. There was little information provided on the recruitment situation and on how the study recruiters would be informed. Although most of the studies were clinical, the possibility was hardly ever discussed that patients could fail to distinguish between care and research. Conclusion The written guidelines, available on the webpages of the ethics committee, do not seem to be enough to help researchers achieve this goal. In addition to detailed guidelines for researchers, investigators need to be taught to appreciate the ethical aspects in their own studies. PMID:22873761

An overview of NASA testing requirements for alternate cleaning solvents used in liquid and gaseous oxygen environments

NASA Technical Reports Server (NTRS)

Strickland, John W.; Davis, S. Eddie

1995-01-01

The elimination of CFC-containing cleaning solvents for oxygen systems has prompted the development of a number of alternative cleaning solvents that must now be evaluated not only for cleanability, but compatibility as well. NASA Handbook 8060.1(NHB 8060.1) establishes the requirements for evaluation, testing, and selection of materials for use in oxygen rich environments. Materials intended for use in space vehicles, specified test facilities, and ground support equipment must meet the requirements of this document. In addition to the requirements of NHB 8060.1 for oxygen service, alternative cleaning solvents must also be evaluated in other areas (such as corrosivity, non-metals compatibility, non-volatile residue contamination, etc.). This paper will discuss the testing requirements of NHB 8060.1 and present preliminary results from early screening tests performed at Marshall Space Flight Center's Materials Combustion Research Facility.

[Activities of Research Institute for Advanced Computer Science

NASA Technical Reports Server (NTRS)

Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

2001-01-01

The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administrations missions. RIACS is located at the NASA Ames Research Center, Moffett Field, California. RIACS research focuses on the three cornerstones of IT research necessary to meet the future challenges of NASA missions: 1. Automated Reasoning for Autonomous Systems Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth. 2. Human-Centered Computing Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities. 3. High Performance Computing and Networking Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to analysis of large scientific datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply IT research to a variety of NASA application domains. RIACS also engages in other activities, such as workshops, seminars, visiting scientist programs and student summer programs, designed to encourage and facilitate collaboration between the university and NASA IT research communities.

A guide to the synthesis of block copolymers using reversible-addition fragmentation chain transfer (RAFT) polymerization.

PubMed

Keddie, Daniel J

2014-01-21

The discovery of reversible-deactivation radical polymerization (RDRP) has provided an avenue for the synthesis of a vast array of polymers with a rich variety of functionality and architecture. The preparation of block copolymers has received significant focus in this burgeoning research field, due to their diverse properties and potential in a wide range of research environments. This tutorial review will address the important concepts behind the design and synthesis of block copolymers using reversible addition-fragmentation chain transfer (RAFT) polymerization. RAFT polymerization is arguably the most versatile of the RDRP methods due to its compatibility with a wide range of functional monomers and reaction media along with its relative ease of use. With an ever increasing array of researchers that possess a variety of backgrounds now turning to RDRP, and RAFT in particular, to prepare their required polymeric materials, it is pertinent to discuss the important points which enable the preparation of high purity functional block copolymers with targeted molar mass and narrow molar mass distribution using RAFT polymerization. The key principles of appropriate RAFT agent selection, the order of monomer addition in block synthesis and potential issues with maintaining high end-group fidelity are addressed. Additionally, techniques which allow block copolymers to be accessed using a combination of RAFT polymerization and complementary techniques are touched upon.

Pandemic influenza-implications for critical care resources in Australia and New Zealand.

PubMed

Anderson, Therese A; Hart, Graeme K; Kainer, Marion A

2003-09-01

To quantify resource requirements (additional beds and ventilator capacity), for critical care services in the event of pandemic influenza. Cross-sectional survey about existing and potential critical care resources. Participants comprised 156 of the 176 Australasian (Australia and New Zealand) critical care units on the database of the Australian and New Zealand Intensive Care Society (ANZICS) Research Centre for Critical Care Resources. The Meltzer, Cox and Fukuda model was adapted to map a range of influenza attack rate estimates for hospitalisation and episodes likely to require intensive care and to predict critical care admission rates and bed day requirements. Estimations of ventilation rates were based on those for community-acquired pneumonia. The estimated extra number of persons requiring hospitalisation ranged from 8,455 (10% attack rate) to 150,087 (45% attack rate). The estimated number of additional admissions to critical care units ranged from 423 (5% admission rate, 10% attack rate) to 37,522 (25% admission rate, 45% attack rate). The potential number of required intensive care bed days ranged from 846 bed days (2 day length of stay, 10% attack rate) to 375,220 bed days (10 day length of stay, 45% attack rate). The number of persons likely to require mechanical ventilation ranged from 106 (25% of projected critical care admissions, 10% attack rate) to 28,142 (75% of projected critical care admissions, 45% attack rate). An additional 1,195 emergency ventilator beds were identified in public sector and 248 in private sector hospitals. Cancellation of elective surgery could release a potential 76,402 intensive care bed days (per annum), but in the event of pandemic influenza, 31,150 bed days could be required over an 8- to 12-week period. Australasian critical care services would be overwhelmed in the event of pandemic influenza. More work is required in relation to modelling, contingency plans, and resource allocation.

Implementation of Complexity Analyzing Based on Additional Effect

NASA Astrophysics Data System (ADS)

Zhang, Peng; Li, Na; Liang, Yanhong; Liu, Fang

According to the Complexity Theory, there is complexity in the system when the functional requirement is not be satisfied. There are several study performances for Complexity Theory based on Axiomatic Design. However, they focus on reducing the complexity in their study and no one focus on method of analyzing the complexity in the system. Therefore, this paper put forth a method of analyzing the complexity which is sought to make up the deficiency of the researches. In order to discussing the method of analyzing the complexity based on additional effect, this paper put forth two concepts which are ideal effect and additional effect. The method of analyzing complexity based on additional effect combines Complexity Theory with Theory of Inventive Problem Solving (TRIZ). It is helpful for designers to analyze the complexity by using additional effect. A case study shows the application of the process.

Informed consent for genetic research.

PubMed

Hamvas, Aaron; Madden, Katherine K; Nogee, Lawrence M; Trusgnich, Michelle A; Wegner, Daniel J; Heins, Hillary B; Cole, F Sessions

2004-06-01

Rapid technological advances in genetic research and public concern about genetic discrimination have led to anticipatory safeguards in the informed consent process in the absence of legal examples of proven discrimination. Despite federal and state regulations to restrict access to personal health information, including genetic information, institutional review boards have required the addition of language to informed consent documents that warns about the risks of discrimination with participation in genetic research. To determine the reasons that families refused consent for their infant's participation in a study evaluating a genetic cause of respiratory distress syndrome. Survey conducted between February 1, 2002, and March 31, 2003. Academic, tertiary free-standing children's hospital. A convenience sample of 465 families were approached for consent. The 135 families who refused consent were surveyed. Reasons for refusal. Of the nonconsenting families, 79% spontaneously and specifically identified institutionally required language in our consent form concerning the risk of denial of access to health insurance and employment as the primary reason for refusal; 97% indicated that their fears resulted directly from language in our consent form. Only 20% of families who refused consent cited inadequate time to consider the study. The institutionally required description of risk of genetic discrimination due solely to participation in genetic research was the primary reason for refusal to consent in this cohort. Information about federally and institutionally mandated protections for confidentiality of participants in genetic research should be included in the informed consent document to balance the description of hypothetical risks and more accurately inform subjects.

Self-directed student research through analysis of microarray datasets: a computer-based functional genomics practical class for masters-level students.

PubMed

Grenville-Briggs, Laura J; Stansfield, Ian

2011-01-01

This report describes a linked series of Masters-level computer practical workshops. They comprise an advanced functional genomics investigation, based upon analysis of a microarray dataset probing yeast DNA damage responses. The workshops require the students to analyse highly complex transcriptomics datasets, and were designed to stimulate active learning through experience of current research methods in bioinformatics and functional genomics. They seek to closely mimic a realistic research environment, and require the students first to propose research hypotheses, then test those hypotheses using specific sections of the microarray dataset. The complexity of the microarray data provides students with the freedom to propose their own unique hypotheses, tested using appropriate sections of the microarray data. This research latitude was highly regarded by students and is a strength of this practical. In addition, the focus on DNA damage by radiation and mutagenic chemicals allows them to place their results in a human medical context, and successfully sparks broad interest in the subject material. In evaluation, 79% of students scored the practical workshops on a five-point scale as 4 or 5 (totally effective) for student learning. More broadly, the general use of microarray data as a "student research playground" is also discussed. Copyright © 2011 Wiley Periodicals, Inc.

Challenges of Achieving 2012 IECC Air Sealing Requirements in Multifamily Dwellings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klocke, S.; Faakye, O.; Puttagunta, S.

2014-10-01

While previous versions of the International Energy Conservation Code (IECC) have included provisions to improve the air tightness of dwellings, for the first time, the 2012 IECC mandates compliance verification through blower door testing. Simply completing the Air Barrier and Insulation Installation checklist through visual inspection is no longer sufficient by itself. In addition, the 2012 IECC mandates a significantly stricter air sealing requirement. In Climate Zones 3 through 8, air leakage may not exceed 3 ACH50, which is a significant reduction from the 2009 IECC requirement of 7 ACH50. This requirement is for all residential buildings, which includes low-risemore » multifamily dwellings. While this air leakage rate requirement is an important component to achieving an efficient building thermal envelope, currently, the code language doesn't explicitly address differences between single family and multifamily applications. In addition, the 2012 IECC does not provide an option to sample dwellings for larger multifamily buildings, so compliance would have to be verified on every unit. With compliance with the 2012 IECC air leakage requirements on the horizon, several of Consortium for Advanced Residential Building's (CARB’s) multifamily builder partners are evaluating how best to comply with this requirement. Builders are not sure whether it is more practical or beneficial to simply pay for guarded testing or to revise their air sealing strategies to improve compartmentalization to comply with code requirements based on unguarded blower door testing. This report summarizes CARB's research that was conducted to assess the feasibility of meeting the 2012 IECC air leakage requirements in 3 multifamily buildings.« less

Building America Case Study: Challenges of Achieving 2012 IECC Air Sealing Requirements in Multifamily Dwellings, Upstate New York (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2014-11-01

While previous versions of the International Energy Conservation Code (IECC) have included provisions to improve the air tightness of dwellings, for the first time, the 2012 IECC mandates compliance verification through blower door testing. Simply completing the Air Barrier and Insulation Installation checklist through visual inspection is no longer sufficient by itself. In addition, the 2012 IECC mandates a significantly stricter air sealing requirement. In Climate Zones 3 through 8, air leakage may not exceed 3 ACH50, which is a significant reduction from the 2009 IECC requirement of 7 ACH50. This requirement is for all residential buildings, which includes low-risemore » multifamily dwellings. While this air leakage rate requirement is an important component to achieving an efficient building thermal envelope, currently, the code language doesn't explicitly address differences between single family and multifamily applications. In addition, the 2012 IECC does not provide an option to sample dwellings for larger multifamily buildings, so compliance would have to be verified on every unit. With compliance with the 2012 IECC air leakage requirements on the horizon, several of CARB's multifamily builder partners are evaluating how best to comply with this requirement. Builders are not sure whether it is more practical or beneficial to simply pay for guarded testing or to revise their air sealing strategies to improve compartmentalization to comply with code requirements based on unguarded blower door testing. This report summarizes CARB's research that was conducted to assess the feasibility of meeting the 2012 IECC air leakage requirements in 3 multifamily buildings.« less

Challenges of Achieving 2012 IECC Air Sealing Requirements in Multifamily Dwellings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klocke, S.; Faakye, O.; Puttagunta, S.

2014-10-01

​While previous versions of the International Energy Conservation Code (IECC) have included provisions to improve the air tightness of dwellings, for the first time, the 2012 IECC mandates compliance verification through blower door testing. Simply completing the Air Barrier and Insulation Installation checklist through visual inspection is no longer sufficient by itself. In addition, the 2012 IECC mandates a significantly stricter air sealing requirement. In Climate Zones 3 through 8, air leakage may not exceed 3 ACH50, which is a significant reduction from the 2009 IECC requirement of 7 ACH50. This requirement is for all residential buildings, which includes low-risemore » multifamily dwellings. While this air leakage rate requirement is an important component to achieving an efficient building thermal envelope, currently, the code language doesn't explicitly address differences between single family and multifamily applications. In addition, the 2012 IECC does not provide an option to sample dwellings for larger multifamily buildings, so compliance would have to be verified on every unit. With compliance with the 2012 IECC air leakage requirements on the horizon, several of CARB's multifamily builder partners are evaluating how best to comply with this requirement. Builders are not sure whether it is more practical or beneficial to simply pay for guarded testing or to revise their air sealing strategies to improve compartmentalization to comply with code requirements based on unguarded blower door testing. This report summarizes CARB's research that was conducted to assess the feasibility of meeting the 2012 IECC air leakage requirements in 3 multifamily buildings.« less

Large Scale Computing and Storage Requirements for High Energy Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerber, Richard A.; Wasserman, Harvey

2010-11-24

The National Energy Research Scientific Computing Center (NERSC) is the leading scientific computing facility for the Department of Energy's Office of Science, providing high-performance computing (HPC) resources to more than 3,000 researchers working on about 400 projects. NERSC provides large-scale computing resources and, crucially, the support and expertise needed for scientists to make effective use of them. In November 2009, NERSC, DOE's Office of Advanced Scientific Computing Research (ASCR), and DOE's Office of High Energy Physics (HEP) held a workshop to characterize the HPC resources needed at NERSC to support HEP research through the next three to five years. Themore » effort is part of NERSC's legacy of anticipating users needs and deploying resources to meet those demands. The workshop revealed several key points, in addition to achieving its goal of collecting and characterizing computing requirements. The chief findings: (1) Science teams need access to a significant increase in computational resources to meet their research goals; (2) Research teams need to be able to read, write, transfer, store online, archive, analyze, and share huge volumes of data; (3) Science teams need guidance and support to implement their codes on future architectures; and (4) Projects need predictable, rapid turnaround of their computational jobs to meet mission-critical time constraints. This report expands upon these key points and includes others. It also presents a number of case studies as representative of the research conducted within HEP. Workshop participants were asked to codify their requirements in this case study format, summarizing their science goals, methods of solution, current and three-to-five year computing requirements, and software and support needs. Participants were also asked to describe their strategy for computing in the highly parallel, multi-core environment that is expected to dominate HPC architectures over the next few years. The report includes a section that describes efforts already underway or planned at NERSC that address requirements collected at the workshop. NERSC has many initiatives in progress that address key workshop findings and are aligned with NERSC's strategic plans.« less

Toxins produced in cyanobacterial water blooms – toxicity and risks

PubMed Central

Bláha, Luděk; Babica, Pavel; Maršálek, Blahoslav

2009-01-01

Cyanobacterial blooms in freshwaters represent a major ecological and human health problem worldwide. This paper briefly summarizes information on major cyanobacterial toxins (hepatotoxins, neurotoxins etc.) with special attention to microcystins-cyclic heptapeptides with high acute and chronic toxicities. Besides discussion of human health risks, microcystin ecotoxicology and consequent ecological risks are also highlighted. Although significant research attention has been paid to microcystins, cyanobacteria produce a wide range of currently unknown toxins, which will require research attention. Further research should also address possible additive, synergistic or antagonistic effects among different classes of cyanobacterial metabolites, as well as interactions with other toxic stressors such as metals or persistent organic pollutants. PMID:21217843

Revolutionary/Unconventional Aeropropulsion Technology Evaluation through Thermodynamic Work Potential: A Revolutionary Aeropropulsion Concepts Program Research Initiative

NASA Technical Reports Server (NTRS)

Mavris, Dimitri; Danner, Travis; Roth, Bryce

2002-01-01

This report is intended as a status report for activities covered May through July 2002 under the auspices of NASA Glenn's Revolutionary Aeropropulsion Concepts (RAC) project. This is the first phase I quarterly report and as such, considerable focus will be given to defining the basic need and motivation driving this research effort. In addition, background research has been ongoing for the past several months and has culminated in considerable information pertaining to the state-of-the-art in work potential analysis methods. This work is described in detail herein. Finally, the proposed analysis approach is described, as are the various ancillary concepts required for its implementation.

Supporting flight data analysis for Space Shuttle Orbiter Experiments at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Green, M. J.; Budnick, M. P.; Yang, L.; Chiasson, M. P.

1983-01-01

The Space Shuttle Orbiter Experiments program in responsible for collecting flight data to extend the research and technology base for future aerospace vehicle design. The Infrared Imagery of Shuttle (IRIS), Catalytic Surface Effects, and Tile Gap Heating experiments sponsored by Ames Research Center are part of this program. The paper describes the software required to process the flight data which support these experiments. In addition, data analysis techniques, developed in support of the IRIS experiment, are discussed. Using the flight data base, the techniques have provided information useful in analyzing and correcting problems with the experiment, and in interpreting the IRIS image obtained during the entry of the third Shuttle mission.

Supporting flight data analysis for Space Shuttle Orbiter experiments at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Green, M. J.; Budnick, M. P.; Yang, L.; Chiasson, M. P.

1983-01-01

The space shuttle orbiter experiments program is responsible for collecting flight data to extend the research and technology base for future aerospace vehicle design. The infrared imagery of shuttle (IRIS), catalytic surface effects, and tile gap heating experiments sponsored by Ames Research Center are part of this program. The software required to process the flight data which support these experiments is described. In addition, data analysis techniques, developed in support of the IRIS experiment, are discussed. Using the flight data base, the techniques provide information useful in analyzing and correcting problems with the experiment, and in interpreting the IRIS image obtained during the entry of the third shuttle mission.

NASA 2010 Pharmacology Evidence Review

NASA Technical Reports Server (NTRS)

Steinberg, Susan

2011-01-01

In 2008, the Institute of Medicine reviewed NASA's Human Research Program Evidence in assessing the Pharmacology risk identified in NASA's Human Research Program Requirements Document (PRD). Since this review there was a major reorganization of the Pharmacology discipline within the HRP, as well as a re-evaluation of the Pharmacology evidence. This panel is being asked to review the latest version of the Pharmacology Evidence Report. Specifically, this panel will: (1) Appraise the descriptions of the human health-related risk in the HRP PRD. (2) Assess the relevance and comprehensiveness of the evidence in identifying potential threats to long-term space missions. (3) Assess the associated gaps in knowledge and identify additional areas for research as necessary.

Using technology to support investigations in the electronic age: tracking hackers to large scale international computer fraud

NASA Astrophysics Data System (ADS)

McFall, Steve

1994-03-01

With the increase in business automation and the widespread availability and low cost of computer systems, law enforcement agencies have seen a corresponding increase in criminal acts involving computers. The examination of computer evidence is a new field of forensic science with numerous opportunities for research and development. Research is needed to develop new software utilities to examine computer storage media, expert systems capable of finding criminal activity in large amounts of data, and to find methods of recovering data from chemically and physically damaged computer storage media. In addition, defeating encryption and password protection of computer files is also a topic requiring more research and development.

Kinetics of Supercritical Water Oxidation

DTIC Science & Technology

1995-12-31

milestone and Sandia Technical Report. A much-needed report describing in detail the operation of the Supercritical Fluids Reactor (SFR) was also...years. In addition, the literature research required to arrive at this optimal design will be used to improve the performance of the Supercritical Fluids ...the Supercritical Fluids Reactor (SFR)" (Sandia National Laboratories Report SAND-8203, Livermore, CA, 1995). R. R. Steeper, "Methane and Methanol

Tier One Performance Screen Initial Operational Test and Evaluation: 2011 Annual Report

DTIC Science & Technology

2013-01-01

OPERATIONAL TEST AND EVALUATION: 2011 ANNUAL REPORT EXECUTIVE SUMMARY Research Requirement: In addition to educational, physical , and...34 Table 5.4. Incremental Validity Estimates for the TAPAS and TOPS Composite Scales over the AFQT for Predicting IMT Physical Fitness Criteria by...Validity Estimates for the TAPAS and TOPS Composite Scales over the AFQT for Predicting In-Unit Physical Fitness Criteria by Education Tier

Tailoring the Acquisition Process in the U.S. Department of Defense

DTIC Science & Technology

2015-01-01

and increase efficiency. In theory , those unique programmatic, technical, political, and economic characteristics should determine the management...need to exist for tailoring to be effective? Our objective was to determine whether this policy area would benefit from additional in-depth research...decision reviews, supportability analysis, and deci - sion levels consistent with all applicable statutory requirements. (DAU, 2012, p. B-223) The

A Normative Database and Determinants of Lexical Retrieval for 186 Arabic Nouns: Effects of Psycholinguistic and Morpho-Syntactic Variables on Naming Latency

ERIC Educational Resources Information Center

Khwaileh, Tariq; Body, Richard; Herbert, Ruth

2014-01-01

Research into lexical retrieval requires pictorial stimuli standardised for key psycholinguistic variables. Such databases exist in a number of languages but not in Arabic. In addition there are few studies of the effects of psycholinguistic and morpho-syntactic variables on Arabic lexical retrieval. The current study identified a set of…

A Global Assessment of Stem Cell Engineering

PubMed Central

Loring, Jeanne F.; McDevitt, Todd C.; Palecek, Sean P.; Schaffer, David V.; Zandstra, Peter W.

2014-01-01

Over the last 2 years a global assessment of stem cell engineering (SCE) was conducted with the sponsorship of the National Science Foundation, the National Cancer Institute at the National Institutes of Health, and the National Institute of Standards and Technology. The purpose was to gather information on the worldwide status and trends in SCE, that is, the involvement of engineers and engineering approaches in the stem cell field, both in basic research and in the translation of research into clinical applications and commercial products. The study was facilitated and managed by the World Technology Evaluation Center. The process involved site visits in both Asia and Europe, and it also included several different workshops. From this assessment, the panel concluded that there needs to be an increased role for engineers and the engineering approach. This will provide a foundation for the generation of new markets and future economic growth. To do this will require an increased investment in engineering, applied research, and commercialization as it relates to stem cell research and technology. It also will require programs that support interdisciplinary teams, new innovative mechanisms for academic–industry partnerships, and unique translational models. In addition, the global community would benefit from forming strategic partnerships between countries that can leverage existing and emerging strengths in different institutions. To implement such partnerships will require multinational grant programs with appropriate review mechanisms. PMID:24428577

A global assessment of stem cell engineering.

PubMed

Loring, Jeanne F; McDevitt, Todd C; Palecek, Sean P; Schaffer, David V; Zandstra, Peter W; Nerem, Robert M

2014-10-01

Over the last 2 years a global assessment of stem cell engineering (SCE) was conducted with the sponsorship of the National Science Foundation, the National Cancer Institute at the National Institutes of Health, and the National Institute of Standards and Technology. The purpose was to gather information on the worldwide status and trends in SCE, that is, the involvement of engineers and engineering approaches in the stem cell field, both in basic research and in the translation of research into clinical applications and commercial products. The study was facilitated and managed by the World Technology Evaluation Center. The process involved site visits in both Asia and Europe, and it also included several different workshops. From this assessment, the panel concluded that there needs to be an increased role for engineers and the engineering approach. This will provide a foundation for the generation of new markets and future economic growth. To do this will require an increased investment in engineering, applied research, and commercialization as it relates to stem cell research and technology. It also will require programs that support interdisciplinary teams, new innovative mechanisms for academic-industry partnerships, and unique translational models. In addition, the global community would benefit from forming strategic partnerships between countries that can leverage existing and emerging strengths in different institutions. To implement such partnerships will require multinational grant programs with appropriate review mechanisms.

Telemedicine in veterinary practice.

PubMed

Mars, M; Auer, R E J

2006-06-01

Veterinary surgeons have a long tradition of consulting one another about problem cases and many have unwittingly practised telemedicine when discussing cases by telephone or by sending laboratory reports by telefax. Specific veterinary telemedicine applications have been in use since the early 1980s, but little research has been undertaken in this field. The Pubmed and CAB International databases were searched for the following Boolean logic-linked keywords; veterinary and telemedicine, veterinary and telecare, animal and telemedicine, animal and telecare and veterinary and e-mail and an additional search was made of the worldwide web, using Google Scholar. This returned 25 papers which were reviewed. Of these only 2 report research. Sixteen papers had no references and 1 author was associated with 13 papers. Several themes emerge in the papers reviewed. These include remarks about the use of telemedicine, the benefits that can and are derived from the use of telemedicine, areas of practice in which telemedicine is being used, ethical and legal issues around the practice of telemedicine, image standards required for telemedicine, the equipment that is required for the practice of telemedicine, advice on ways in which digital images can be obtained and educational aspects of telemedicine. These are discussed. Veterinary practice has lagged behind its human counterpart in producing research on the validity and efficacy of telemedicine. This is an important field which requires further research.

Flight test evaluation of the E-systems Differential GPS category 3 automatic landing system

NASA Technical Reports Server (NTRS)

Kaufmann, David N.; Mcnally, B. David

1995-01-01

Test flights were conducted to evaluate the capability of Differential Global Positioning System (DGPS) to provide the accuracy and integrity required for International Civil Aviation Organization (ICAO) Category (CAT) III precision approach and landings. These test flights were part of a Federal Aviation Administration (FAA) program to evaluate the technical feasibility of using DGPS based technology for CAT III precision approach and landing applications. An IAI Westwind 1124 aircraft (N24RH) was equipped with DGPS receiving equipment and additional computing capability provided by E-Systems. The test flights were conducted at NASA Ames Research Center's Crows Landing Flight Facility, Crows Landing, California. The flight test evaluation was based on completing 100 approaches and landings. The navigation sensor error accuracy requirements were based on ICAO requirements for the Microwave Landing System (MLS). All of the approaches and landings were evaluated against ground truth reference data provided by a laser tracker. Analysis of these approaches and landings shows that the E-Systems DGPS system met the navigation sensor error requirements for a successful approach and landing 98 out of 100 approaches and landings, based on the requirements specified in the FAA CAT III Level 2 Flight Test Plan. In addition, the E-Systems DGPS system met the integrity requirements for a successful approach and landing or stationary trial for all 100 approaches and landings and all ten stationary trials, based on the requirements specified in the FAA CAT III Level 2 Flight Test Plan.

Development and analysis of SCR requirements tables for system scenarios

NASA Technical Reports Server (NTRS)

Callahan, John R.; Morrison, Jeffery L.

1995-01-01

We describe the use of scenarios to develop and refine requirement tables for parts of the Earth Observing System Data and Information System (EOSDIS). The National Aeronautics and Space Administration (NASA) is developing EOSDIS as part of its Mission-To-Planet-Earth (MTPE) project to accept instrument/platform observation requests from end-user scientists, schedule and perform requested observations of the Earth from space, collect and process the observed data, and distribute data to scientists and archives. Current requirements for the system are managed with tools that allow developers to trace the relationships between requirements and other development artifacts, including other requirements. In addition, the user community (e.g., earth and atmospheric scientists), in conjunction with NASA, has generated scenarios describing the actions of EOSDIS subsystems in response to user requests and other system activities. As part of a research effort in verification and validation techniques, this paper describes our efforts to develop requirements tables from these scenarios for the EOSDIS Core System (ECS). The tables specify event-driven mode transitions based on techniques developed by the Naval Research Lab's (NRL) Software Cost Reduction (SCR) project. The SCR approach has proven effective in specifying requirements for large systems in an unambiguous, terse format that enhance identification of incomplete and inconsistent requirements. We describe development of SCR tables from user scenarios and identify the strengths and weaknesses of our approach in contrast to the requirements tracing approach. We also evaluate the capabilities of both approach to respond to the volatility of requirements in large, complex systems.

A study to define a set of requirements for cleansing agents for use in the Space Station whole body shower

NASA Technical Reports Server (NTRS)

1985-01-01

The objective of this research is to define a set of requirements for a whole body cleansing agent to be used in the Space Station Whole Body Shower System. In addition, cleansing agent candidates are to be identified that are likely to satisfy requirements defined in the first part of the study. It is understood that the main reason for having a Whole Body Shower is to satisfy the physiological, psychological and social needs of the crew throughout the duration of duty in the Space Station. The cleansing agent must also be compatible with the vortex water/gas separator and the water reclamation system. To accomplish these goals the study was divided into six tasks.

Integrating water and agricultural management: collaborative governance for a complex policy problem.

PubMed

Fish, Rob D; Ioris, Antonio A R; Watson, Nigel M

2010-11-01

This paper examines governance requirements for integrating water and agricultural management (IWAM). The institutional arrangements for the agriculture and water sectors are complex and multi-dimensional, and integration cannot therefore be achieved through a simplistic 'additive' policy process. Effective integration requires the development of a new collaborative approach to governance that is designed to cope with scale dependencies and interactions, uncertainty and contested knowledge, and interdependency among diverse and unequal interests. When combined with interdisciplinary research, collaborative governance provides a viable normative model because of its emphasis on reciprocity, relationships, learning and creativity. Ultimately, such an approach could lead to the sorts of system adaptations and transformations that are required for IWAM. Copyright © 2009 Elsevier B.V. All rights reserved.

Methods and Processes of Developing the Strengthening the Reporting of Observational Studies in Epidemiology-Veterinary (STROBE-Vet) Statement.

PubMed

Sargeant, J M; O'Connor, A M; Dohoo, I R; Erb, H N; Cevallos, M; Egger, M; Ersbøll, A K; Martin, S W; Nielsen, L R; Pearl, D L; Pfeiffer, D U; Sanchez, J; Torrence, M E; Vigre, H; Waldner, C; Ward, M P

2016-12-01

Reporting of observational studies in veterinary research presents challenges that often are not addressed in published reporting guidelines. Our objective was to develop an extension of the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement that addresses unique reporting requirements for observational studies in veterinary medicine related to health, production, welfare, and food safety. We conducted a consensus meeting with 17 experts in Mississauga, Canada. Experts completed a premeeting survey about whether items in the STROBE statement should be modified or added to address unique issues related to observational studies in animal species with health, production, welfare, or food safety outcomes. During the meeting, each STROBE item was discussed to determine whether or not rewording was recommended, and whether additions were warranted. Anonymous voting was used to determine consensus. Six items required no modifications or additions. Modifications or additions were made to the STROBE items 1 (title and abstract), 3 (objectives), 5 (setting), 6 (participants), 7 (variables), 8 (data sources and measurement), 9 (bias), 10 (study size), 12 (statistical methods), 13 (participants), 14 (descriptive data), 15 (outcome data), 16 (main results), 17 (other analyses), 19 (limitations), and 22 (funding). The methods and processes used were similar to those used for other extensions of the STROBE statement. The use of this STROBE statement extension should improve reporting of observational studies in veterinary research by recognizing unique features of observational studies involving food-producing and companion animals, products of animal origin, aquaculture, and wildlife.

IRB Problems and Solutions in Health Communication Research.

PubMed

King, Carie S Tucker; Bivens, Kristin Marie; Pumroy, Erin; Rauch, Susan; Koerber, Amy

2018-07-01

In this article, we contribute to the current literature on the difficulties that social scientists encounter with IRBs, but with a focus on the distinct challenges that health communication scholars face in dealing with IRBs at their own institutions and elsewhere. Although health communication researchers, like other communication researchers, can expect to face many of the same challenges that their social science colleagues face during the IRB process, the researcher narratives we present in this article suggest that health communication research presents some distinct challenges because the communication interactions that we investigate occur in highly protected, private spaces, including the medical exam room, online patient forums, and electronic health records. To that end, we present a series of examples in which health communication researchers were able to find solutions or workarounds to the challenges they faced in gaining IRB approval for their research. In every case that we present, the researcher had to revise her initial study design to get around the constraints imposed by IRB requirements, and in every case, the researcher reports having experienced points of incommensurability similar to those reported by many other social scientists. In some situations, investigators even express frustration that the IRB's needs and demands superseded those of healthcare professionals and the patients whom they serve. Additionally, in some situations, investigators' understandings of human subjects' protection actually go further to protect patients' privacy and confidentiality than the IRB required. But, in all four cases that we present, the health communication research was ultimately successful.

Fusion Energy Sciences Exascale Requirements Review. An Office of Science review sponsored jointly by Advanced Scientific Computing Research and Fusion Energy Sciences, January 27-29, 2016, Gaithersburg, Maryland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Choong-Seock; Greenwald, Martin; Riley, Katherine

The additional computing power offered by the planned exascale facilities could be transformational across the spectrum of plasma and fusion research — provided that the new architectures can be efficiently applied to our problem space. The collaboration that will be required to succeed should be viewed as an opportunity to identify and exploit cross-disciplinary synergies. To assess the opportunities and requirements as part of the development of an overall strategy for computing in the exascale era, the Exascale Requirements Review meeting of the Fusion Energy Sciences (FES) community was convened January 27–29, 2016, with participation from a broad range ofmore » fusion and plasma scientists, specialists in applied mathematics and computer science, and representatives from the U.S. Department of Energy (DOE) and its major computing facilities. This report is a summary of that meeting and the preparatory activities for it and includes a wealth of detail to support the findings. Technical opportunities, requirements, and challenges are detailed in this report (and in the recent report on the Workshop on Integrated Simulation). Science applications are described, along with mathematical and computational enabling technologies. Also see http://exascaleage.org/fes/ for more information.« less

Air Force construction automation/robotics

NASA Technical Reports Server (NTRS)

Nease, AL; Dusseault, Christopher

1994-01-01

The Air Force has several unique requirements that are being met through the development of construction robotic technology. The missions associated with these requirements place construction/repair equipment operators in potentially harmful situations. Additionally, force reductions require that human resources be leveraged to the maximum extent possible and that more stringent construction repair requirements push for increased automation. To solve these problems, the U.S. Air Force is undertaking a research and development effort at Tyndall AFB, FL to develop robotic teleoperation, telerobotics, robotic vehicle communications, automated damage assessment, vehicle navigation, mission/vehicle task control architecture, and associated computing environment. The ultimate goal is the fielding of robotic repair capability operating at the level of supervised autonomy. The authors of this paper will discuss current and planned efforts in construction/repair, explosive ordnance disposal, hazardous waste cleanup, fire fighting, and space construction.

The inherent weaknesses in industrial control systems devices; hacking and defending SCADA systems

NASA Astrophysics Data System (ADS)

Bianco, Louis J.

The North American Electric Reliability Corporation (NERC) is about to enforce their NERC Critical Infrastructure Protection (CIP) Version Five and Six requirements on July 1st 2016. The NERC CIP requirements are a set of cyber security standards designed to protect cyber assets essential the reliable operation of the electric grid. The new Version Five and Six requirements are a major revision to the Version Three (currently enforced) requirements. The new requirements also bring substations into scope alongside Energy Control Centers. When the Version Five requirements were originally drafted they were vague, causing in depth discussions throughout the industry. The ramifications of these requirements has made owners look at their systems in depth, questioning how much money it will take to meet these requirements. Some owners saw backing down from routable networks to non-routable as a means to save money as they would be held to less requirements within the standards. Some owners saw removing routable connections as a proper security move. The purpose of this research was to uncover the inherent weaknesses in Industrial Control Systems (ICS) devices; to show how ICS devices can be hacked and figure out potential protections for these Critical Infrastructure devices. In addition, this research also aimed to validate the decision to move from External Routable connectivity to Non-Routable connectivity, as a security measure and not as a means of savings. The results reveal in order to ultimately protect Industrial Control Systems they must be removed from the Internet and all bi-directional external routable connections must be removed. Furthermore; non-routable serial connections should be utilized, and these non-routable serial connections should be encrypted on different layers of the OSI model. The research concluded that most weaknesses in SCADA systems are due to the inherent weaknesses in ICS devices and because of these weaknesses, human intervention is the biggest threat to SCADA systems.

The Vulnerabilities of Orphaned Children Participating in Research: A Critical Review and Factors for Consideration for Participation in Biomedical and Behavioral Research

PubMed Central

Thompson, Rachel T.; Meslin, Eric M.; Braitstein, Paula K. A.; Nyandiko, Winstone M.; Ayaya, Samuel O.; Vreeman, Rachel C.

2013-01-01

Orphans are a subpopulation with a unique set of additional vulnerabilities. Increasing focus on children’s rights, pediatric global health, and pediatric research makes it imperative to recognize and address unique vulnerabilities of orphaned children. This paper describes the unique vulnerabilities of the orphaned pediatric population and offers a structured set of factors that require consideration when including orphans in biomedical research. Pediatric orphans are particularly vulnerable due to decreased economic resources, psychosocial instability, increased risk of abuse, and delayed/decreased access to healthcare. These vulnerabilities are significant. By carefully considering each issue in a population in a culturally specific and study-specific manner, researchers can make valuable contributions to the overall health and well-being of this uniquely vulnerable population. PMID:23086048

10 CFR 20.2302 - Additional requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

10 CFR 20.2302 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

10 CFR 20.2302 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Additional requirements. 20.2302 Section 20.2302 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Exemptions and Additional Requirements § 20.2302 Additional requirements. The Commission may, by rule, regulation, or order, impose...

Research into software executives for space operations support

NASA Technical Reports Server (NTRS)

Collier, Mark D.

1990-01-01

Research concepts pertaining to a software (workstation) executive which will support a distributed processing command and control system characterized by high-performance graphics workstations used as computing nodes are presented. Although a workstation-based distributed processing environment offers many advantages, it also introduces a number of new concerns. In order to solve these problems, allow the environment to function as an integrated system, and present a functional development environment to application programmers, it is necessary to develop an additional layer of software. This 'executive' software integrates the system, provides real-time capabilities, and provides the tools necessary to support the application requirements.

Geopotential research mission, science, engineering and program summary

NASA Technical Reports Server (NTRS)

Keating, T. (Editor); Taylor, P. (Editor); Kahn, W. (Editor); Lerch, F. (Editor)

1986-01-01

This report is based upon the accumulated scientific and engineering studies pertaining to the Geopotential Research Mission (GRM). The scientific need and justification for the measurement of the Earth's gravity and magnetic fields are discussed. Emphasis is placed upon the studies and conclusions of scientific organizations and NASA advisory groups. The engineering design and investigations performed over the last 4 years are described, and a spacecraft design capable of fulfilling all scientific objectives is presented. In addition, critical features of the scientific requirements and state-of-the-art limitations of spacecraft design, mission flight performance, and data processing are discussed.

Natural Resources Research Program: Proceedings of the Annual Meeting, Natural Resources Research Program (14th) Held in Omaha, Nebraska on 19-20 April 1989

DTIC Science & Technology

1989-09-01

here in Omaha. First, I’d like to mention a change we’ve made in the process for reviewing proposed programs for approval in HQUSACE. As most of you... changing markets, we must be more structured in the way we determine what, when, and where to provide our products and how much they are worth. We need to...the O&M area because the projects are on the ground, demands on these projects are changing , and new projects that require additional dollars are

Armstrong Flight Research Center Flight Test Capabilities and Opportunities for the Applications of Wireless Data Acquisition Systems

NASA Technical Reports Server (NTRS)

Hang, Richard

2015-01-01

The presentation will overview NASA Armstrong Flight Research Centers flight test capabilities, which can provide various means for flight testing of passive and active wireless sensor systems, also, it will address the needs of the wireless data acquisition solutions for the centers flight instrumentation issues such as additional weight caused by added instrumentation wire bundles, connectors, wire cables routing, moving components, etc., that the Passive Wireless Sensor Technology Workshop may help. The presentation shows the constraints and requirements that the wireless sensor systems will face in the flight test applications.

Zero-gravity atmospheric Cloud Physics Experiment Laboratory; Programmatics report

NASA Technical Reports Server (NTRS)

1974-01-01

The programmatics effort included comprehensive analyses in four major areas: (1) work breakdown structure, (2) schedules, (3) costs, and (4) supporting research and technology. These analyses are discussed in detail in the following sections which identify and define the laboratory project development schedule, cost estimates, funding distributions and supporting research and technology requirements. All programmatics analyses are correlated among themselves and with the technical analyses by means of the work breakdown structure which serves as a common framework for program definition. In addition, the programmatic analyses reflect the results of analyses and plans for reliability, safety, test, and maintenance and refurbishment.

Primary data collection in health technology assessment.

PubMed

McIsaac, Michelle L; Goeree, Ron; Brophy, James M

2007-01-01

This study discusses the value of primary data collection as part of health technology assessment (HTA). Primary data collection can help reduce uncertainty in HTA and better inform evidence-based decision making. However, methodological issues such as choosing appropriate study design and practical concerns such as the value of collecting additional information need to be addressed. The authors emphasize the conditions required for successful primary data collection in HTA: experienced researchers, sufficient funding, and coordination among stakeholders, government, and researchers. The authors conclude that, under specific conditions, primary data collection is a worthwhile endeavor in the HTA process.

An overview of expert systems. [artificial intelligence

NASA Technical Reports Server (NTRS)

Gevarter, W. B.

1982-01-01

An expert system is defined and its basic structure is discussed. The knowledge base, the inference engine, and uses of expert systems are discussed. Architecture is considered, including choice of solution direction, reasoning in the presence of uncertainty, searching small and large search spaces, handling large search spaces by transforming them and by developing alternative or additional spaces, and dealing with time. Existing expert systems are reviewed. Tools for building such systems, construction, and knowledge acquisition and learning are discussed. Centers of research and funding sources are listed. The state-of-the-art, current problems, required research, and future trends are summarized.

The NASA/NSERC Student Airborne Research Program Land Focus Group - a Paid Training Program in Multi-Disciplinary STEM Research for Terrestrial Remote Sensing

NASA Astrophysics Data System (ADS)

Kefauver, S. C.; Ustin, S.; Davey, S. W.; Furey, B. J.; Gartner, A.; Kurzweil, D.; Siebach, K. L.; Slawsky, L.; Snyder, E.; Trammell, J.; Young, J.; Schaller, E.; Shetter, R. E.

2011-12-01

The Student Airborne Research Program (SARP) of the National Aeronautics and Space Administration (NASA) and the National Suborbital Education and Research Center (NSERC) is a unique six week multidisciplinary paid training program which directly integrates students into the forefront of airborne remote sensing science. Students were briefly trained with one week of lectures and laboratory exercises and then immediately incorporated into ongoing research projects which benefit from access to the DC-8 airborne platform and the MODIS-ASTER Airborne Simulator (MASTER) sensor. Students were split into three major topical categories of Land, Ocean, and Air for the data collection and project portions of the program. This poster details the techniques and structure used for the student integration into ongoing research, professional development, hypothesis building and results as developed by the professor and mentor of the Land focus group. Upon assignment to the Land group, students were issued official research field protocols and split into four field specialty groups with additional specialty reading assignments. In the field each group spent more time in their respective specialty, but also participated in all field techniques through pairings with UC Davis research team members using midday rotations. After the field campaign, each specialty group then gave summary presentations on the techniques, preliminary results, and significance to overall group objectives of their specialty. Then students were required to submit project proposals within the bounds of Land airborne remote sensing science and encouraging, but not requiring the use of the field campaign data. These proposals are then reviewed by the professor and mentor and students are met with one by one to discuss the skills of each student and objectives of the proposed research project. The students then work under the supervision of the mentor and benefit again from professor feedback in a formal practice presentation session. At the end of the six week program, students present to all SARP program focus groups, mentors, professors, and, in addition, NSERC and NASA airborne science and education program directors and personnel.

Research and the planned Space Experiment Research and Processing Laboratory

NASA Technical Reports Server (NTRS)

2000-01-01

Original photo and caption dated June 22, 1988: 'A dwarf wheat variety known as Yecoro Rojo flourishes in KSC's Biomass Production Chamber. Researchers are gathering information on the crop's ability to produce food, water and oxygen, and then remove carbon dioxide. The confined quarters associated with space travel require researchers to focus on smaller plants that yield proportionately large amounts of biomass. This wheat crop takes about 85 days to grow before harvest.' Plant experiments such as this are the type of life sciences research that will be conducted at the Space Experiment Research Procession Laboratory (SERPL). The SERPL is a planned 100,000-square-foot laboratory that will provide expanded and upgraded facilities for hosting International Space Station experiment processing. In addition, it will provide better support for other biological and life sciences payload processing at KSC. It will serve as a magnet facility for a planned 400-acre Space Station Commerce Park.

Annual review of cultural resource investigations by the Savannah River Archaeological Research Program, fiscal year 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-11-01

The Savannah River Archaeological Research Program (SRARP) of the South Carolina Institute of Archaeology and Anthropology, University of South Carolina, is funded through a direct contract with the United States Department of Energy to provide services required under federal law for the protection and management of archaeological resources on the Savannah River Site (SRS). Because the significance of most archaeological resources is dependent upon research potential, the SRARP is guided by research objectives. An on-going research program provides the problems, methods and means of assessing site significance within the compliance process specified by law. In addition, the SRARP maintains anmore » active program of public education to disseminate knowledge about prehistory and history, and to enhance public awareness about historic preservation. The following report summarizes the management, research and public education activities of the SRARP during Fiscal Year 1990.« less

Communicating Risks and Benefits in Informed Consent for Research: A Qualitative Study

PubMed Central

Nusbaum, Lika; Douglas, Brenda; Damus, Karla; Paasche-Orlow, Michael; Estrella-Luna, Neenah

2017-01-01

Multiple studies have documented major limitations in the informed consent process for the recruitment of clinical research participants. One challenging aspect of this process is successful communication of risks and benefits to potential research participants. This study explored the opinions and attitudes of informed consent experts about conveying risks and benefits to inform the development of a survey about the perspectives of research nurses who are responsible for obtaining informed consent for clinical trials. The major themes identified were strategies for risks and benefits communication, ensuring comprehension, and preparation for the role of the consent administrator. From the experts’ perspective, inadequate education and training of the research staff responsible for informed consent process contribute to deficiencies in the informed consent process and risks and benefits communication. Inconsistencies in experts’ opinions and critique of certain widely used communication practices require further consideration and additional research. PMID:28975139

Defining Attributes and Metrics of Effective Research Mentoring Relationships

PubMed Central

Byars-Winston, Angela; Branchaw, Janet; Hurtado, Sylvia; Eagan, Kevin

2016-01-01

Despite evidence of mentoring’s importance in training researchers, studies to date have not yet determined which mentoring relationships have the most impact and what specific factors in those mentoring relationships contribute to key outcomes, such as the commitment to and persistence in research career paths for emerging researchers from diverse populations. Efforts to broaden participation and persistence in biomedical research careers require an understanding of why and how mentoring relationships work and their impact, not only to research training but also to promoting career advancement. This paper proposes core attributes of effective mentoring relationships, as supported by the literature and suggested by theoretical models of academic persistence. In addition, both existing and developing metrics for measuring the effectiveness of these attributes within mentoring relationships across diverse groups are presented, as well as preliminary data on these metrics from the authors’ work. PMID:27062425

Project management of life-science research projects: project characteristics, challenges and training needs.

PubMed

Beukers, Margot W

2011-02-01

Thirty-four project managers of life-science research projects were interviewed to investigate the characteristics of their projects, the challenges they faced and their training requirements. A set of ten discriminating parameters were identified based on four project categories: contract research, development, discovery and call-based projects--projects set up to address research questions defined in a call for proposals. The major challenges these project managers are faced with relate to project members, leadership without authority and a lack of commitment from the respective organization. Two-thirds of the project managers indicated that they would be interested in receiving additional training, mostly on people-oriented, soft skills. The training programs that are currently on offer, however, do not meet their needs. Copyright © 2010 Elsevier Ltd. All rights reserved.

The storybook method: research feedback with young participants.

PubMed

Anderson, Kate; Balandin, Susan

2011-12-01

Children are valuable informants for social research; however, their participation presents additional ethical and practical challenges. Of these challenges, feedback to verify the researchers' interpretations drawn from children's data, and the dissemination of project findings to young participants, have proven difficult to overcome. In this paper, we outline the Storybook method, an approach to feedback in research with young children. In the example study, illustrations, interactive pop-ups, and third-person disclosure were used to aid children aged 7-9 years to overcome the power imbalance in interviews with adults. The Storybook method facilitated active participation in the validation process. Potential modifications of the method for use with older populations, including adults with intellectual disabilities, complex communication needs, and those requiring alternate access to written texts, are also explored.

[Introduction of a Clinical Research Experience Program in Hospital Practical Training for Pharmacy Students and Its Evaluation].

PubMed

Takahashi, Katsuyuki; Suda, Yasuki; Kawaguchi, Hiroshi; Nakamura, Yasutaka; Kawabata, Shiho; Kawakami, Noriko; Nishikawa, Takeshi; Nagayama, Katsuya

2015-01-01

Long-term clinical training based on a model core curriculum was conducted to nurture highly competent pharmacists in the clinical field. Pharmacists' responsibilities are expanding, and a system has been developed to help pharmacists gain accreditation, identify specialties, and improve their training. However, this system requires research competency. Therefore clinical research should be considered a part of clinical training to encourage high competency among pharmacists. Because the model core curriculum does not include a section on clinical research. Osaka City University Hospital introduced a hands-on clinical research experience program and evaluated its usefulness. A significant improvement in the level of knowledge and awareness of clinical research was seen among students who underwent the clinical research experience program. In addition, the level of student satisfaction was higher. These findings suggest that a clinical research experience program may be useful to nurture a greater awareness of clinical research and knowledge acquisition among pharmacists.

Tennessee State University (TSU) Research Project For Increasing The Pool of Minority Engineers

NASA Technical Reports Server (NTRS)

Rogers, Decatur B.; Merritt, Sylvia (Technical Monitor)

2000-01-01

The NASA Glenn Research Center funded the 1998-1999 Tennessee State University (TSU) Research Project for Increasing the Pool of Minority Engineers. The NASA/GRC-TSU Research Project developed a cadre of engineers who have academic and research expertise in technical areas of interest to NASA, in addition to having some familiarity with the mission of the NASA/Glenn Research Center. Increased minority participation in engineering was accomplished by: (1) introducing and exposing minority youth to engineering careers and to the required high school preparation necessary to access engineering through two campus based precollege programs: Minority Introduction to Engineering (MITE), and Engineering and Technology Previews; (2) providing financial support through the Research Scholars Program for minority youth majoring in engineering disciplines of interest to NASA; (3) familiarization with the engineering profession and with NASA through field trips and summer internships at the Space and Rocket Center, and (4) with practical research exposure and experiences through research internships at NASA/GRC and at TSU.

Career development for the clinician-educator. Optimizing impact and maximizing success.

PubMed

Roberts, David H; Schwartzstein, Richard M; Weinberger, Steven E

2014-02-01

Health care professionals in pulmonary, critical care, and sleep medicine play key roles as teachers for learners of all levels in both clinical care and scientific investigation. Teaching excellence requires training in principles of adult learning and the acquisition and practice of key professional skills including assessment and feedback techniques, curriculum development, and strategies for effective teaching across venues ranging from the bedside to the lecture hall. Those interested in pursuing teaching as the focus of their academic career and basis for promotion should invest in professional development as a teacher and educator. Professional development activities include obtaining additional training as a teacher in dedicated medical education fellowships or serving as a peer observer or being observed by a fellow teacher. Numerous additional options for training as a teacher and educator are now available including resource repositories, continuing medical education courses, and online training modules. Those with an interest in medical education research may benefit from enrollment in masters or other advanced degree programs focused on the qualitative and quantitative methods and other key research skills. Aspiring clinician-educators should also seek out opportunities to participate in a community of medical educators locally, regionally, nationally, and internationally. At each of these levels, there exist opportunities to contribute to course or program design, development, and evaluation. Finally, for those interested in promotion as an academic clinician-educator, there are increasing requirements to produce academic scholarship ranging from curricular materials to journal articles focused on education and education research.

'I do the best I can': an in-depth exploration of the aphasia management pathway in the acute hospital setting.

PubMed

Foster, Abby M; Worrall, Linda E; Rose, Miranda L; O'Halloran, Robyn

2016-09-01

While research has begun to explore the management of aphasia across the continuum of care, to date there is little in-depth, context specific knowledge relating to the speech pathology aphasia management pathway. This research aimed to provide an in-depth understanding of the current aphasia management pathway in the acute hospital setting, from the perspective of speech pathologists. Underpinned by a social constructivist paradigm, the researchers implemented an interpretive phenomenological method when conducting in-depth interviews with 14 Australian speech pathologists working in the acute hospital setting. Interview transcripts and interviewer field notes were subjected to a qualitative content analysis. Analysis identified a single guiding construct and five main categories to describe the management of aphasia in the acute hospital setting. The guiding construct, First contact with the profession, informed the entire management pathway. Five additional main categories were identified: Referral processes; Screening and assessment; Therapeutic intervention; Educational and affective counselling; and Advocacy. Findings suggest significant diversity in the pathways of care for people with aphasia and their families in the acute hospital setting. Additional support mechanisms are required in order to support speech pathologists to minimise the evidence-practice gap. Implications for Rehabilitation Significant diversity exists in the current aphasia management pathway for people with acute post-stroke aphasia and their families in the acute hospital setting. Mechanisms that support speech pathologists to minimise the evidence-practice gap, and consequently reduce their sense of professional dissonance, are required.

Alternative splicing in plant immunity.

PubMed

Yang, Shengming; Tang, Fang; Zhu, Hongyan

2014-06-10

Alternative splicing (AS) occurs widely in plants and can provide the main source of transcriptome and proteome diversity in an organism. AS functions in a range of physiological processes, including plant disease resistance, but its biological roles and functional mechanisms remain poorly understood. Many plant disease resistance (R) genes undergo AS, and several R genes require alternatively spliced transcripts to produce R proteins that can specifically recognize pathogen invasion. In the finely-tuned process of R protein activation, the truncated isoforms generated by AS may participate in plant disease resistance either by suppressing the negative regulation of initiation of immunity, or by directly engaging in effector-triggered signaling. Although emerging research has shown the functional significance of AS in plant biotic stress responses, many aspects of this topic remain to be understood. Several interesting issues surrounding the AS of R genes, especially regarding its functional roles and regulation, will require innovative techniques and additional research to unravel.

Identification and Analysis of Critical Gaps in Nuclear Fuel Cycle Codes Required by the SINEMA Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adrian Miron; Joshua Valentine; John Christenson

2009-10-01

The current state of the art in nuclear fuel cycle (NFC) modeling is an eclectic mixture of codes with various levels of applicability, flexibility, and availability. In support of the advanced fuel cycle systems analyses, especially those by the Advanced Fuel Cycle Initiative (AFCI), Unviery of Cincinnati in collaboration with Idaho State University carried out a detailed review of the existing codes describing various aspects of the nuclear fuel cycle and identified the research and development needs required for a comprehensive model of the global nuclear energy infrastructure and the associated nuclear fuel cycles. Relevant information obtained on the NFCmore » codes was compiled into a relational database that allows easy access to various codes' properties. Additionally, the research analyzed the gaps in the NFC computer codes with respect to their potential integration into programs that perform comprehensive NFC analysis.« less

Comment on "Influence of shaft length on golf driving performance".

PubMed

Glazier, Paul S

2009-06-01

Kenny et al. (2008) reported that low-handicap golfers were able to produce longer carry distances with longer drivers with no concomitant decrease in accuracy. However, it was not clear whether these increments in performance were an artefact of shaft length or some other unaccounted for characteristic of the experimental drivers used. Furthermore, it was difficult to determine whether these performance gains were experienced by all or only a few of the golfers studied. Additional research is required to substantiate these findings and also to establish how shaft length is related to performance and technique in less accomplished golfers. Regardless of skill level, the realization of the potential performance benefits associated with longer drivers is, to some degree, likely to be individual-specific. Accordingly, suitable research designs emphasizing the individual--with appropriate sample and trial sizes to achieve the requisite level of statistical significance, effect size, and power--are required.

Progress Towards Environmentally Friendlier Automobiles

NASA Astrophysics Data System (ADS)

Culver, Robert

2002-03-01

The United States Council for Automotive Research (USCAR), the umbrella organization of DaimlerChrysler, Ford, and General Motors, has been conducting pre-competitive research in the areas of improving fuel efficiency and reducing tailpipe emissions. One of the major collaborations is with the U.S. Government in the Partnership for a New Generation of Vehicles (PNGV). The USCAR/PNGV technology portfolio includes lightweight materials, improved conventional internal combustion engine systems, electric traction and hybridization, and fuel cells. Significant progress has been made in developing these technologies and marketing them through today’s vehicles. New product announcements of hybrids demonstrate the commitment of the industry to bring the new technologies to market. Yet, breakthroughs and innovations will be required before many of the technologies can fully realize their promise. In addition, government policies and programs will be required to promote market acceptance and ensure an infrastructure to provide new fuels.

Optimal design in pediatric pharmacokinetic and pharmacodynamic clinical studies.

PubMed

Roberts, Jessica K; Stockmann, Chris; Balch, Alfred; Yu, Tian; Ward, Robert M; Spigarelli, Michael G; Sherwin, Catherine M T

2015-03-01

It is not trivial to conduct clinical trials with pediatric participants. Ethical, logistical, and financial considerations add to the complexity of pediatric studies. Optimal design theory allows investigators the opportunity to apply mathematical optimization algorithms to define how to structure their data collection to answer focused research questions. These techniques can be used to determine an optimal sample size, optimal sample times, and the number of samples required for pharmacokinetic and pharmacodynamic studies. The aim of this review is to demonstrate how to determine optimal sample size, optimal sample times, and the number of samples required from each patient by presenting specific examples using optimal design tools. Additionally, this review aims to discuss the relative usefulness of sparse vs rich data. This review is intended to educate the clinician, as well as the basic research scientist, whom plan on conducting a pharmacokinetic/pharmacodynamic clinical trial in pediatric patients. © 2015 John Wiley & Sons Ltd.

Suicidal behavior in the older patient with schizophrenia

PubMed Central

Kasckow, John; Montross, Lori; Prunty, Laurie; Fox, Lauren; Zisook, Sidney

2011-01-01

Little is known about treating elderly suicidal patients with schizophrenia. The purpose of this article is to review the literature dealing with this population and to discuss what is required to advance this field. Most available studies from middle-aged and older individuals suggest that risk factors include hopelessness, lower quality of life, past traumatic events, depressive symptoms, lifetime suicidal ideation and past attempts; it is not clear whether these findings are generalizable to geriatric populations. Although little treatment research has been performed in older suicidal patients with schizophrenia, an integrated psychosocial and pharmacologic approach is recommended. In addition, one recent study augmented antipsychotic treatment with an SSRI (i.e., citalopram) in a sample of middle-aged and older individuals with schizophrenia with subsyndromal depression; in that study, serotonin selective reuptake inhibitor augmentation reduced depressive symptoms and suicidal ideation. More research is required to better understand suicidal behavior in older patients with schizophrenia. PMID:22028735

Investigation of gamma ray shielding efficiency and mechanical performances of concrete shields containing bismuth oxide as an environmentally friendly additive

NASA Astrophysics Data System (ADS)

Yao, Ya; Zhang, Xiaowen; Li, Mi; Yang, Rong; Jiang, Tianjiao; Lv, Junwen

2016-10-01

Concrete has a proven ability to attenuate gamma rays and neutrons without compromising structural property; therefore, it is widely used as the primary shielding material in many nuclear facilities. Recently, there is a tendency toward using various additives to enhance the shielding properties of these concrete mixtures. However, most of these additives being used either pose hygiene hazards or require special handling processes. It would be ideal if environmentally friendly additives were available for use. The bismuth oxide (Bi2O3) additive shows promise in various shielding applications due to its proven radiation attenuation ability and environmentally friendly nature. To the best of our knowledge, however, Bi2O3 has never been used in concrete mixtures. Therefore, for this research, we fabricated the Bi2O3-based concrete mixtures by adding Bi2O3 powder in the ordinary concrete mixture. Concrete mixtures with lead oxide (PbO) additives were used for comparison. Radiation shielding parameters like the linear attenuation coefficients (LAC) of all these concrete mixtures showing the effects of the Bi2O3 additions are presented. The mechanical performances of concrete mixtures incorporated with Bi2O3 additive were also investigated. It suggested that the concrete mixture containing 25% Bi2O3 powder (B5 in this study) provided the best shielding capacity and mechanical performance among other mixes. It has a significant potential for application as a structural concrete where radiological protection capability is required.

Bureaucracy stifles medical research in Britain: a tale of three trials.

PubMed

Snooks, Helen; Hutchings, Hayley; Seagrove, Anne; Stewart-Brown, Sarah; Williams, John; Russell, Ian

2012-08-16

Recent developments aiming to standardise and streamline processes of gaining the necessary approvals to carry out research in the National Health Service (NHS) in the United Kingdom (UK), have resulted in lengthy and costly delays. The national UK governmental Department of Health's Research Governance Framework (RGF) for Health and Social Care requires that appropriate checks be conducted before research involving human participants, their organs, tissues or data can commence in the NHS. As a result, medical research has been subjected to increased regulation and governance, with the requirement for approvals from numerous regulatory and monitoring bodies. In addition, the processes and outcomes of the attribution of costs in NHS research have caused additional difficulties for researchers. The purpose of this paper is to illustrate, through three trial case studies, the difficulties encountered during the set-up and recruitment phases of these trials, related to gaining the necessary ethical and governance approvals and applying for NHS costs to undertake and deliver the research. Empirical evidence about delays and difficulties related to regulation and governance of medical research was gathered during the period 2009-2010 from three UK randomised controlled trials with sites in England, Wales and Scotland (1. SAFER 2- an emergency care based trial of a protocol for paramedics to refer patients directly to community based falls services; 2. COnStRUCT- a trial of two drugs for acute ulcerative colitis; and 3. Family Links - a trial of a public health intervention, a 10 week community based parenting programme). Findings and recommendations were reported in response to a call for evidence from The Academy of Medical Sciences regarding difficulties encountered in conducting medical research arising from R&D governance and regulation, to inform national policy. Difficulties and delays in navigating and gaining the appropriate approvals and NHS costs required to undertake the research were encountered in all three trials, at various points in the bureaucratic processes of ethical and research and information governance approvals. Conduct of each of the three trials was delayed by at least 12 months, with costs increasing by 30 - 40%. Whilst the three trials encountered a variety of challenges, there were common issues. The processes for gaining approvals were overly complex and differed between sites and UK countries; guidance about processes was unclear; and information regarding how to define and claim NHS costs for undertaking the research was inconsistent. The competitive advantage of a publicly funded, open access health system for undertaking health services research and clinical trials within the UK has been outweighed in recent years by stifling bureaucratic structures and processes for governance of research. The recommendations of the Academy of Medical Sciences are welcomed, and the effects of their implementation are awaited with interest. SAFER 2: ISRCTN 60481756; COnStRUCT: ISRCTN22663589; Family Links: ISRCTN 13929732.

10 CFR 55.7 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition to...

10 CFR 55.7 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Additional requirements. 55.7 Section 55.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.7 Additional requirements. The Commission may, by rule, regulation, or order, impose upon any licensee such requirements, in addition to...

Recent Advances in Nanotechnology for Diabetes Treatment

PubMed Central

DiSanto, Rocco Michael; Subramanian, Vinayak; Gu, Zhen

2015-01-01

Nanotechnology in diabetes research has facilitated the development of novel glucose measurement and insulin delivery modalities which hold the potential to dramatically improve quality of life for diabetics. Recent progress in the field of diabetes research at its interface with nanotechnology is our focus. In particular, we examine glucose sensors with nanoscale components including metal nanoparticles and carbon nanostructures. The addition of nanoscale components commonly increases glucose sensor sensitivity, temporal response, and can lead to sensors which facilitate continuous in vivo glucose monitoring. Additionally, we survey nanoscale approaches to “closed-loop” insulin delivery strategies which automatically release insulin in response to fluctuating blood glucose levels. “Closing the loop” between blood glucose level (BGL) measurements and insulin administration by removing the requirement of patient action holds the potential to dramatically improve the health and quality of life of diabetics. Advantages and limitations of current strategies, as well as future opportunities and challenges are also discussed. PMID:25641955

Quantifying atom addition reactions on amorphous solid water: a review of recent laboratory advances

NASA Astrophysics Data System (ADS)

He, Jiao; Vidali, Gianfranco

2018-06-01

Complex organic molecules found in space are mostly formed on and in the ice mantle covering interstellar dust grains. In clouds where ionizing irradiation is insignificant, chemical reactions on the ice mantle are dominated by thermal processes. Modeling of grain surface chemistry requires detailed information from the laboratory, including sticking coefficients, binding energies, diffusion energy barriers, mechanism of reaction, and chemical desorption rates. In this talk, recent laboratory advances in obtaining these information would be reviewed. Specifically, this talk will focus on the efforts in our group in: 1) Determining the mechanism of atomic hydrogen addition reactions on amorphous solid water (ASW); 2) Measuring the chemical desorption coefficient of H+O3-->O2+OH using the time-resolved scattering technique; and 3) Measuring the diffusion energy barrier of volatile molecules on ASW. Further laboratory studies will be suggested.This research was supported by NSF Astronomy & Astrophysics Research Grant #1615897.

Edible packaging materials.

PubMed

Janjarasskul, Theeranun; Krochta, John M

2010-01-01

Research groups and the food and pharmaceutical industries recognize edible packaging as a useful alternative or addition to conventional packaging to reduce waste and to create novel applications for improving product stability, quality, safety, variety, and convenience for consumers. Recent studies have explored the ability of biopolymer-based food packaging materials to carry and control-release active compounds. As diverse edible packaging materials derived from various by-products or waste from food industry are being developed, the dry thermoplastic process is advancing rapidly as a feasible commercial edible packaging manufacturing process. The employment of nanocomposite concepts to edible packaging materials promises to improve barrier and mechanical properties and facilitate effective incorporation of bioactive ingredients and other designed functions. In addition to the need for a more fundamental understanding to enable design to desired specifications, edible packaging has to overcome challenges such as regulatory requirements, consumer acceptance, and scaling-up research concepts to commercial applications.

Evaluating the impact and costs of deploying an electronic medical record system to support TB treatment in Peru

PubMed Central

Fraser, Hamish SF; Blaya, Joaquin; Choi, Sharon S; Bonilla, Cesar; Jazayeri, Darius

2006-01-01

The PIH-EMR is a Web based electronic medical record that has been in operation for over four years in Peru supporting the treatment of drug resistant TB. We describe here the types of evaluations that have been performed on the EMR to assess its impact on patient care, reporting, logistics and observational research. Formal studies have been performed on components for drug order entry, drug requirements prediction tools and the use of PDAs to collect bacteriology data. In addition less formal data on the use of the EMR for reporting and research are reviewed. Experience and insights from porting the PIH-EMR to the Philippines, and modifying it to support HIV treatment in Haiti and Rwanda are discussed. We propose that additional data of this sort is valuable in assessing medical information systems especially in resource poor areas. PMID:17238344

Evaluating the impact and costs of deploying an electronic medical record system to support TB treatment in Peru.

PubMed

Fraser, Hamish S F; Blaya, Joaquin; Choi, Sharon S; Bonilla, Cesar; Jazayeri, Darius

2006-01-01

The PIH-EMR is a Web based electronic medical record that has been in operation for over four years in Peru supporting the treatment of drug resistant TB. We describe here the types of evaluations that have been performed on the EMR to assess its impact on patient care, reporting, logistics and observational research. Formal studies have been performed on components for drug order entry, drug requirements prediction tools and the use of PDAs to collect bacteriology data. In addition less formal data on the use of the EMR for reporting and research are reviewed. Experience and insights from porting the PIH-EMR to the Philippines, and modifying it to support HIV treatment in Haiti and Rwanda are discussed. We propose that additional data of this sort is valuable in assessing medical information systems especially in resource poor areas.

Otolaryngology Residency Program Research Resources and Scholarly Productivity.

PubMed

Villwock, Jennifer A; Hamill, Chelsea S; Nicholas, Brian D; Ryan, Jesse T

2017-06-01

Objective To delineate research resources available to otolaryngology residents and their impact on scholarly productivity. Study Design Survey of current otolaryngology program directors. Setting Otolaryngology residency programs. Subjects and Methods An anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors. Fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. Results Thirty-nine percent (n = 38) of queried programs responded. Fourteen (37%) programs had 11 to 15 full-time, academic faculty associated with the residency program. Twenty (53%) programs have a dedicated research coordinator. Basic science lab space and financial resources for statistical work were present at 22 programs (58%). Funding is uniformly provided for presentation of research at conferences; a minority of programs (13%) only funded podium presentations. Twenty-four (63%) have resident research requirements beyond the Accreditation Council for Graduate Medical Education (ACGME) mandate of preparing a "manuscript suitable for publication" prior to graduation. Twenty-five (67%) programs have residents with 2 to 3 active research projects at any given time. None of the investigated resources were significantly associated with increased scholarly output. There was no uniformity to research curricula. Conclusions Otolaryngology residency programs value research, evidenced by financial support provided and requirements beyond the ACGME minimum. Additional resources were not statistically related to an increase in resident research productivity, although they may contribute positively to the overall research experience during training. Potential future areas to examine include research curricula best practices, how to develop meaningful mentorship and resource allocation that inspires continued research interest, and intellectual stimulation.

Reproducibility in Computational Neuroscience Models and Simulations

PubMed Central

McDougal, Robert A.; Bulanova, Anna S.; Lytton, William W.

2016-01-01

Objective Like all scientific research, computational neuroscience research must be reproducible. Big data science, including simulation research, cannot depend exclusively on journal articles as the method to provide the sharing and transparency required for reproducibility. Methods Ensuring model reproducibility requires the use of multiple standard software practices and tools, including version control, strong commenting and documentation, and code modularity. Results Building on these standard practices, model sharing sites and tools have been developed that fit into several categories: 1. standardized neural simulators, 2. shared computational resources, 3. declarative model descriptors, ontologies and standardized annotations; 4. model sharing repositories and sharing standards. Conclusion A number of complementary innovations have been proposed to enhance sharing, transparency and reproducibility. The individual user can be encouraged to make use of version control, commenting, documentation and modularity in development of models. The community can help by requiring model sharing as a condition of publication and funding. Significance Model management will become increasingly important as multiscale models become larger, more detailed and correspondingly more difficult to manage by any single investigator or single laboratory. Additional big data management complexity will come as the models become more useful in interpreting experiments, thus increasing the need to ensure clear alignment between modeling data, both parameters and results, and experiment. PMID:27046845

Parallel Processing of Images in Mobile Devices using BOINC

NASA Astrophysics Data System (ADS)

Curiel, Mariela; Calle, David F.; Santamaría, Alfredo S.; Suarez, David F.; Flórez, Leonardo

2018-04-01

Medical image processing helps health professionals make decisions for the diagnosis and treatment of patients. Since some algorithms for processing images require substantial amounts of resources, one could take advantage of distributed or parallel computing. A mobile grid can be an adequate computing infrastructure for this problem. A mobile grid is a grid that includes mobile devices as resource providers. In a previous step of this research, we selected BOINC as the infrastructure to build our mobile grid. However, parallel processing of images in mobile devices poses at least two important challenges: the execution of standard libraries for processing images and obtaining adequate performance when compared to desktop computers grids. By the time we started our research, the use of BOINC in mobile devices also involved two issues: a) the execution of programs in mobile devices required to modify the code to insert calls to the BOINC API, and b) the division of the image among the mobile devices as well as its merging required additional code in some BOINC components. This article presents answers to these four challenges.

The 3D dynamics of the Cosserat rod as applied to continuum robotics

NASA Astrophysics Data System (ADS)

Jones, Charles Rees

2011-12-01

In the effort to simulate the biologically inspired continuum robot's dynamic capabilities, researchers have been faced with the daunting task of simulating---in real-time---the complete three dimensional dynamics of the "beam-like" structure which includes the three "stiff" degrees-of-freedom transverse and dilational shear. Therefore, researchers have traditionally limited the difficulty of the problem with simplifying assumptions. This study, however, puts forward a solution which makes no simplifying assumptions and trades off only the real-time requirement of the desired solution. The solution is a Finite Difference Time Domain method employing an explicit single step method with cheap right hands sides. The cheap right hand sides are the result of a rather ingenious formulation of the classical beam called the Cosserat rod by, first, the Cosserat brothers and, later, Stuart S. Antman which results in five nonlinear but uncoupled equations that require only multiplication and addition. The method is therefore suitable for hardware implementation thus moving the real-time requirement from a software solution to a hardware solution.

Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.

PubMed

Li, Ming; de Graaf, Inge A M; Groothuis, Geny M M

2016-01-01

The absorption, distribution, metabolism, excretion and toxicity (ADME-tox) processes of drugs are of importance and require preclinical investigation intestine in addition to the liver. Various models have been developed for prediction of ADME-tox in the intestine. In this review, precision-cut intestinal slices (PCIS) are discussed and highlighted as model for ADME-tox studies. This review provides an overview of the applications and an update of the most recent research on PCIS as an ex vivo model to study the transport, metabolism and toxicology of drugs and other xenobiotics. The unique features of PCIS and the differences with other models as well as the translational aspects are also discussed. PCIS are a simple, fast, and reliable ex vivo model for drug ADME-tox research. Therefore, PCIS are expected to become an indispensable link in the in vitro-ex vivo-in vivo extrapolation, and a bridge in translation of animal data to the human situation. In the future, this model may be helpful to study the effects of interorgan interactions, intestinal bacteria, excipients and drug formulations on the ADME-tox properties of drugs. The optimization of culture medium and the development of a (cryo)preservation technique require more research.

Characterizing heavy metal build-up on urban road surfaces: implication for stormwater reuse.

PubMed

Liu, An; Liu, Liang; Li, Dunzhu; Guan, Yuntao

2015-05-15

Stormwater reuse is increasingly popular in the worldwide. In terms of urban road stormwater, it commonly contains toxic pollutants such as heavy metals, which could undermine the reuse safety. The research study investigated heavy metal build-up characteristics on urban roads in a typical megacity of South China. The research outcomes show the high variability in heavy metal build-up loads among different urban road sites. The degree of traffic congestion and road surface roughness was found to exert a more significant influence on heavy metal build-up rather than traffic volume. Due to relatively higher heavy metal loads, stormwater from roads with more congested traffic conditions or rougher surfaces might be suitable for low-water-quality required activities while the stormwater from by-pass road sections could be appropriate for relatively high-water-quality required purposes since the stormwater could be relatively less polluted. Based on the research outcomes, a decision-making process for heavy metals based urban road stormwater reuse was proposed. The new finding highlights the importance to undertaking a "fit-for-purpose" road stormwater reuse strategy. Additionally, the research results can also contribute to enhancing stormwater reuse safety. Copyright © 2015 Elsevier B.V. All rights reserved.

Additive manufacture (3d printing) of plasma diagnostic components and assemblies for fusion experiments

NASA Astrophysics Data System (ADS)

Sieck, Paul; Woodruff, Simon; Stuber, James; Romero-Talamas, Carlos; Rivera, William; You, Setthivoine; Card, Alexander

2015-11-01

Additive manufacturing (or 3D printing) is now becoming sufficiently accurate with a large range of materials for use in printing sensors needed universally in fusion energy research. Decreasing production cost and significantly lowering design time of energy subsystems would realize significant cost reduction for standard diagnostics commonly obtained through research grants. There is now a well-established set of plasma diagnostics, but these expensive since they are often highly complex and require customization, sometimes pace the project. Additive manufacturing (3D printing) is developing rapidly, including open source designs. Basic components can be printed for (in some cases) less than 1/100th costs of conventional manufacturing. We have examined the impact that AM can have on plasma diagnostic cost by taking 15 separate diagnostics through an engineering design using Conventional Manufacturing (CM) techniques to determine costs of components and labor costs associated with getting the diagnostic to work as intended. With that information in hand, we set about optimizing the design to exploit the benefits of AM. Work performed under DOE Contract DE-SC0011858.

Cost effectiveness analysis for nursing research.

PubMed

Bensink, Mark E; Eaton, Linda H; Morrison, Megan L; Cook, Wendy A; Curtis, R Randall; Gordon, Deborah B; Kundu, Anjana; Doorenbos, Ardith Z

2013-01-01

With ever-increasing pressure to reduce costs and increase quality, nurses are faced with the challenge of producing evidence that their interventions and care provide value. Cost effectiveness analysis (CEA) is a tool that can be used to provide this evidence by comparative evaluation of the costs and consequences of two or more alternatives. The aim of this article is to introduce the essential components of CEA to nurses and nurse researchers with the protocol of a recently funded cluster randomized controlled trial as an example. This article provides (a) a description of the main concepts and key steps in CEA and (b) a summary of the background and objectives of a CEA designed to evaluate a nursing-led pain and symptom management intervention in rural communities compared with the current usual care. As the example highlights, incorporating CEA into nursing research studies is feasible. The burden of the additional data collection required is offset by quantitative evidence of the given intervention's cost and impact using humanistic and economic outcomes. At a time when U.S. healthcare is moving toward accountable care, the information provided by CEA will be an important additional component of the evidence produced by nursing research.

Arabidopsis research requires a critical re-evaluation of genetic tools.

PubMed

Nikonorova, Natalia; Yue, Kun; Beeckman, Tom; De Smet, Ive

2018-06-27

An increasing number of reports question conclusions based on loss-of-function lines that have unexpected genetic backgrounds. In this opinion paper, we urge researchers to meticulously (re)investigate phenotypes retrieved from various genetic backgrounds and be critical regarding some previously drawn conclusions. As an example, we provide new evidence that acr4-2 mutant phenotypes with respect to columella stem cells are due to the lack of ACR4 and not - at least not as a major contributor - to a mutation in QRT1. In addition, we take the opportunity to alert the scientific community about the qrt1-2 background of a large number of Syngenta Arabidopsis Insertion Library (SAIL) T-DNA lines, a feature that is not commonly recognized by Arabidopsis researchers. This qrt1-2 background might have an important impact on the interpretation of the results obtained using these research tools, now and in the past. In conclusion, as a community, we should continuously assess and - if necessary - correct our conclusions based on the large number of (genetic) tools our work is built on. In addition, the positive or negative results of this self-criticism should be made available to the scientific community.

Science in a Team Environment (AKA, How to Play Nicely with Others)

NASA Technical Reports Server (NTRS)

Platts, S. H.; Primeaux, L.; Swarmer, T.; Yarbough, P. O

2017-01-01

So you want to do NASA funded research in a spaceflight analog? There are several things about participating in an HRP managed analog that may be different from the way you normally do work in your laboratory. The purpose of this presentation is to highlight those differences and explain some of the unique aspects of doing this research. Participation in an HRP funded analog study complement, even if initially selected for funding, is not automatic and involves numerous actions from ISSMP, HRP, and the PI. There are steps that have to be taken and processes to follow before approval and ISSMP-FA integration. After the proposal and acceptance process the Investigator works closely with the Flight Analog team to ensure full integration of their study requirements into a compliment. A complement is comprised of a group of studies requiring a common platform and/or scenario that are able to be integrated on a non-interference basis for implementation. Full integration into the analog platform can be broken down into three phases: integration, preparation, and implementation. These phases occur in order with some overlap in the integration and preparation phase. The ISSMP-FA team integrates, plans and implements analog study complements. Properly defining your research requirements and getting them documented is one of the most critical components to ensure successful integration and implementation of your study, but is also one of the most likely to be neglected by PIs. Requirements that are not documented, or that are documented poorly are unlikely to get done, no matter how much you push. The process to document requirements is two-fold, consisting of an initial individual requirements integration and then a compliment requirements integration. Understanding the requirements in detail and early ensures that the science is not compromised by outside influences. This step is vital to the integration, preparation, and implementation phases. The individual requirements integration is the first step in ensuring that the research fits into an available analog platform or allows for the Flight Analog team to provide information on structural study changes for participation in the analog. At this early point investigators need to understand exactly what their requirements are to produce relevant data and convey their must have needs to the Flight Analog team. The fluid nature of analog platforms allow for minor alterations to the operational structure. Participation in analog research requires flexibility from the investigator to ensure implementation of their research into a flight like analog platform. The compliment integration requires plasticity; investigators are asked to work closely with one another and the Flight Analog team to combine research studies into a single study plan. This study plan's ultimate goal is to facilitate multiple study participation with minimal scientific impact to each individual study. The Flight Analogs team works to find the best compromise for all parties while protecting the flight like atmosphere of a particular analog. Additional restrictions, limitations and constraints may be required by the analog in order to make all of the science work. Many studies need to be combined into each complement and there are a limited number of hours available for data collection. Through data/sample sharing, we can reduce the burden on the test subject, while usually avoiding significant science impacts. Restrictions on food, exercise, medications and sleep cycle are important to consider for your research.

Development of new Dutch Elm disease-tolerant selections for restoration of the American Elm in urban and forested landscapes

Treesearch

C.C. Pinchot; C.E. Flower; K.S. Knight; C. Marks; R. Minocha; D. Lesser; K. Woeste; P.G. Schaberg; B. Baldwin; D.M. Delatte; T.D. Fox; N. Hayes-Plazolles; B. Held; K. Lehtoma; S. Long; S. Mattix; A. Sipes; J.M. Slavicek

2017-01-01

The goal of our research and development efforts is to restore American elm (Ulmus americana) as a species in both natural and urban landscapes. Accomplishing this goal requires identification/generation of additional American elm cultivars that are tolerant to Dutch elm disease (DED) caused by Ophiostoma ulmi and O. novo-ulmi, and development of methods to reintroduce...

Families of Children with Down Syndrome: What We Know and What We Need to Know

ERIC Educational Resources Information Center

Cuskelly, Monica; Hauser-Cram, Penny; Van Riper, Marcia

2009-01-01

This paper provides a brief overview of what is currently known about families of children with Down syndrome. In addition, it highlights a number of issues that require further research if we are to have a thorough understanding of the impact of a child with Down syndrome on families as a system and on the individuals who make up that system.…

The United States Air Force Academy Solar Energy Research

DTIC Science & Technology

1980-07-01

controller, ir the solar sy .4tem, is malfunctioning. Put simply, the house will get cold. lf oh cUrs the occupant will notify civil engineering mainte...with this product has been Revere Copper Laminated Panel Sys - trial uses, condenser tubing, electrical of vital assistance in accumulating the tern...Laminated Panel require water temperatures near the additional components Include tubes,. Construction. In the Revere Panel Sys - boiling point,whereas

High-Fidelity Simulations of Electromagnetic Propagation and RF Communication Systems

DTIC Science & Technology

2017-05-01

addition to high -fidelity RF propagation modeling, lower-fidelity mod- els, which are less computationally burdensome, are available via a C++ API...expensive to perform, requiring roughly one hour of computer time with 36 available cores and ray tracing per- formed by a single high -end GPU...ER D C TR -1 7- 2 Military Engineering Applied Research High -Fidelity Simulations of Electromagnetic Propagation and RF Communication

Electromagnetic Pulse (EMP) Handbook for Air Force Communications Service Communications-Electronics-Meteorological Engineers

DTIC Science & Technology

1976-11-01

protec- tion and will require additional measures, such as the application of conductive filter-loaded plastic resins to each joint connection...Lawrence Liver- more Laboratory, Livermore CA, 1974 31. Whitson, A. L., "DCA HEMP Hardness Certification Methodology Status", Stanford Research...of Chief of Engineers, Depot of the Army, December 1971 34. "Development of HEMP Assessment Methodology for Satellite Terminals", Intelcom Rad Tech

Investigating Approaches to Achieve Modularity Benefits in the Acquisition Ecosystem

DTIC Science & Technology

2017-06-09

actions and that of others, and how the assessments are affected by their actions. • Case study approach based on best practices, tacit knowledge... case study -derived exemplars, and items requiring further research on identifying additional enablers and useful knowledge constructs. All of these... case studies that document the effective use of modularity in system design for some or all of innovation, competition, cost, technology and

The National Shipbuilding Research Program 1985 Ship Production Symposium Volume 1

DTIC Science & Technology

1985-09-01

though there is some impact on hull construction progress because assembly is performed in shops which provide ideal climate, lighting, and access...with the production of parts is necessary in order to pay employees , report performance to budget and compute productivity. The latter requirement is...progress estimates in addition to the employees normal timecards. Even this can be eliminated by using completion of previously performed tasks as

Assessing Weapon System Acquisition Cycle Times: Setting Program Schedules

DTIC Science & Technology

2015-06-01

additional research, focused as follows: 1 . Acquisition schedule development: How are schedules for acquisition programs actually set and how are they...the germinating requirements documents specific to systems reviewed. A clear statement was found for only one system (Air and Missile Defense Radar...AMDR) when specific threat capabilities were projected to be operational. • Program schedule setting varies in rigor: 1 Up to the interim version of

The Effectiveness of Professional Development Using a Checklist of Common Core State Standards for Mathematical Practice for Designing and Delivering Instruction on Algebra I Achievement

ERIC Educational Resources Information Center

Peretin, Janeen

2014-01-01

This study was designed to determine whether or not the use of focused professional development using a checklist based on the Common Core State Standards Mathematical Practices impacted students' math scores as measured by an assessment that requires the use of the practices. Additionally, the researcher sought to determine whether or not the use…

Security issues in healthcare applications using wireless medical sensor networks: a survey.

PubMed

Kumar, Pardeep; Lee, Hoon-Jae

2012-01-01

Healthcare applications are considered as promising fields for wireless sensor networks, where patients can be monitored using wireless medical sensor networks (WMSNs). Current WMSN healthcare research trends focus on patient reliable communication, patient mobility, and energy-efficient routing, as a few examples. However, deploying new technologies in healthcare applications without considering security makes patient privacy vulnerable. Moreover, the physiological data of an individual are highly sensitive. Therefore, security is a paramount requirement of healthcare applications, especially in the case of patient privacy, if the patient has an embarrassing disease. This paper discusses the security and privacy issues in healthcare application using WMSNs. We highlight some popular healthcare projects using wireless medical sensor networks, and discuss their security. Our aim is to instigate discussion on these critical issues since the success of healthcare application depends directly on patient security and privacy, for ethic as well as legal reasons. In addition, we discuss the issues with existing security mechanisms, and sketch out the important security requirements for such applications. In addition, the paper reviews existing schemes that have been recently proposed to provide security solutions in wireless healthcare scenarios. Finally, the paper ends up with a summary of open security research issues that need to be explored for future healthcare applications using WMSNs.

Security Issues in Healthcare Applications Using Wireless Medical Sensor Networks: A Survey

PubMed Central

Kumar, Pardeep; Lee, Hoon-Jae

2012-01-01

Healthcare applications are considered as promising fields for wireless sensor networks, where patients can be monitored using wireless medical sensor networks (WMSNs). Current WMSN healthcare research trends focus on patient reliable communication, patient mobility, and energy-efficient routing, as a few examples. However, deploying new technologies in healthcare applications without considering security makes patient privacy vulnerable. Moreover, the physiological data of an individual are highly sensitive. Therefore, security is a paramount requirement of healthcare applications, especially in the case of patient privacy, if the patient has an embarrassing disease. This paper discusses the security and privacy issues in healthcare application using WMSNs. We highlight some popular healthcare projects using wireless medical sensor networks, and discuss their security. Our aim is to instigate discussion on these critical issues since the success of healthcare application depends directly on patient security and privacy, for ethic as well as legal reasons. In addition, we discuss the issues with existing security mechanisms, and sketch out the important security requirements for such applications. In addition, the paper reviews existing schemes that have been recently proposed to provide security solutions in wireless healthcare scenarios. Finally, the paper ends up with a summary of open security research issues that need to be explored for future healthcare applications using WMSNs. PMID:22368458

Research Project for Increasing the Pool of Minority Engineers

NASA Technical Reports Server (NTRS)

Gott, Susan F. (Technical Monitor); Rogers, Decatur B.

2003-01-01

The NASA Glenn Research Center (GRC) funded the 2001-2002 Tennessee State University (TSU) Research Project for increasing the pool of minority engineers. The NASA GRC/TSU Research Project is designed to develop a cadre of SMET professionals who have academic and research expertise in technical areas of interest to NASA, in addition to having some familiarity with the mission of the NASA Glenn Research Center. The goal of increasing minority participation in SMET disciplines was accomplished by: (1) introducing and exposing 96 minority youth to Science, Math, Engineering, and Technology (SMET) careers and to the required high school preparation necessary to make high school graduation, college attendance and engineering careers a reality through the campus based pre-college SMET program: Minority Introduction to Engineering (MITE); (2) by providing financial support through scholarships for four (4) TSU engineering students to NASA; (3) familiarization with the SMET profession and with NASA through summer internships at NASA GRC for two TSU NASA Glenn Research Scholars; and experiences through research internships at NASA GRC.

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

46 CFR 11.502 - Additional requirements for engineer endorsements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Additional requirements for engineer endorsements. 11... SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.502 Additional requirements for engineer endorsements. (a) For all original and raise of grade of engineer...

The Proceedings of the Skylab Life Sciences Symposium, volume 2

NASA Technical Reports Server (NTRS)

Johnston, R. S.; Dietlein, L. F.

1974-01-01

The three manned Skylab missions resulted in biomedical experiment data in the areas of neurophysiology, musculoskeletal physiology, biochemistry, hematology, cytology, cardiovascular and respiratory metabolic functions: as well as detailed test objectives involving crew health and environment procedures. Major emphasis was placed on results from the last mission, Skylab 4, which covered 84 days of in-flight data collection. Many new norms were defined for normal man living and operating in a unique environment. While man is quite adaptable to this unique environment, many of the changes observed in Skylab require additional research for future flights lasting very long periods of time such as a Mars mission requiring 18 months.

When synthetic chemicals degrade in the environment: What are the absolute fate, effects, and potential risks to humans and the ecosystem?

USGS Publications Warehouse

Boxall, Alistair; Sinclair, C.; Fenner, Kathrin; Kolpin, Dana W.; Maund, S.

2004-01-01

Although some regulatory schemes require information about the impacts of degradates on human and environmental health, that information does not exist for many compounds (25, 26). Pesticides are the exception. In this article, we bring together the available data to address the environmental behavior of degradates and their effects on organisms and discuss how to identify substances of potential concern. In addition, we cite gaps in the current knowledge and make recommendations for future research requirements. While the article focuses on pesticides, we believe these observations can be extended to biologically active compounds and some industrial substances.

Stress fractures about the tibia, foot, and ankle.

PubMed

Shindle, Michael K; Endo, Yoshimi; Warren, Russell F; Lane, Joseph M; Helfet, David L; Schwartz, Elliott N; Ellis, Scott J

2012-03-01

In competitive athletes, stress fractures of the tibia, foot, and ankle are common and lead to considerable delay in return to play. Factors such as bone vascularity, training regimen, and equipment can increase the risk of stress fracture. Management is based on the fracture site. In some athletes, metabolic workup and medication are warranted. High-risk fractures, including those of the anterior tibial diaphysis, navicular, proximal fifth metatarsal, and medial malleolus, present management challenges and may require surgery, especially in high-level athletes who need to return to play quickly. Noninvasive treatment modalities such as pulsed ultrasound and extracorporeal shock wave therapy may have some benefit but require additional research.

Power management and distribution considerations for a lunar base

NASA Technical Reports Server (NTRS)

Kenny, Barbara H.; Coleman, Anthony S.

1991-01-01

Design philosophies and technology needs for the power management and distribution (PMAD) portion of a lunar base power system are discussed. A process is described whereby mission planners may proceed from a knowledge of the PMAD functions and mission performance requirements to a definition of design options and technology needs. Current research efforts at the NASA LRC to meet the PMAD system needs for a Lunar base are described. Based on the requirements, the lunar base PMAD is seen as best being accomplished by a utility like system, although with some additional demands including autonomous operation and scheduling and accurate, predictive modeling during the design process.

Plant Cell Division Analyzed by Transient Agrobacterium-Mediated Transformation of Tobacco BY-2 Cells.

PubMed

Buschmann, Henrik

2016-01-01

The continuing analysis of plant cell division will require additional protein localization studies. This is greatly aided by GFP-technology, but plant transformation and the maintenance of transgenic lines can present a significant technical bottleneck. In this chapter I describe a method for the Agrobacterium-mediated genetic transformation of tobacco BY-2 cells. The method allows for the microscopic analysis of fluorescence-tagged proteins in dividing cells in within 2 days after starting a coculture. This transient transformation procedure requires only standard laboratory equipment. It is hoped that this rapid method would aid researchers conducting live-cell localization studies in plant mitosis and cytokinesis.

The Proceedings of the Skylab Life Sciences Symposium, Volume 1

NASA Technical Reports Server (NTRS)

Johnston, R. S.; Dietlein, L. F.

1974-01-01

The three manned Skylab missions resulted in biomedical experiment data in the areas of neurophysiology, musculoskeletal physiology, biochemistry, hematology, cytology, cardiovascular and respiratory metabolic functions: as well as detailed test objectives involving crew health and environment procedures. Major emphasis was placed on results from the last mission, Skylab 4, which covered 84 days of in-flight data collection. Many new norms were defined for normal man living and operating in a unique environment. While man is quite adaptable to this unique environment, many of the changes observed in Skylab require additional research for future flights lasting very long periods of time such as a Mars mission requiring 18 months.

The 1995 NASA guide to graduate support

NASA Technical Reports Server (NTRS)

1994-01-01

The future of the United States is in the classrooms of America and tomorrow's scientific and technological capabilities are derived from today's investments in research. In 1980, NASA initiated the Graduate Student Researchers Program (GSRP) to cultivate additional research ties to the academic community and to support promising students pursuing advanced degrees in science and engineering. Since then, approximately 1300 students have completed the program's requirements. In 1987, the program was expanded to include the Underrepresented Minority and Disabled Focus (UMDF) Component. This program was designed to increase participation of underrepresented groups in graduate study and research and, ultimately, in space science and aerospace technology careers. Approximately 270 minority students have completed the program's requirements while making significant contributions to the nation's aerospace efforts. Continuing to expand fellowship opportunities, NASA announced the Graduate Student Fellowships in Global Change Research in 1990. Designed to support the rapid growth in the study of earth as a system, more than 250 fellowships have been awarded. And, in 1992, NASA announced opportunities in the multiagency High Performance Computing and Communications (HPCC) Program designed to accelerate the development and application of massively parallel processing. Approximately five new fellowships will be awarded yearly. This booklet will guide you in your efforts to participate in programs for graduate student support.

Usability evaluation of the digital anger thermometer app.

PubMed

Mattson, Donald C

2017-09-01

The digital anger thermometer is a prototype for a mobile application (app) for use with adults in anger management treatment. The digital anger thermometer incorporates standards of software development in addition to anger management resources from the Substance Abuse and Mental Health Services Administration. The digital anger thermometer underwent a usability study conducted by five expert reviewers. The results indicate that it is easy to learn, efficient, and ergonomically sound. However, it does not offer support features or user-error tolerance. The digital anger thermometer prototype requires additional usability studies and comparative research in order for it to become an actual mental health app.

American Diabetes Association position statement: evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications.

PubMed

2002-01-01

Medical nutrition therapy for people with diabetes should be individualized, with consideration given to the individual's usual food and eating habits, metabolic profile, treatment goals and desired outcomes. Monitoring of metabolic parameters, including glucose, HbA1c, lipids, blood pressure, body weight, and renal function, when appropriate, as well as quality of life is essential to assess the need for changes in therapy and ensure successful outcomes. Ongoing nutrition self-management education and care needs to be available for individuals with diabetes. Additionally many areas of nutrition and diabetes require additional research.

Research on oxygen recovery systems for use in space capsules

NASA Technical Reports Server (NTRS)

Selman, J. R.; Steunenberg, R. K.; Cairns, E. J.

1973-01-01

An improved electrochemical process was investigated for the recovery of oxygen from the atmospheres of manned space capsules. The objective of the proposed system is to recover the oxygen from CO2 with high efficiency and to recover the additional amount of oxygen from water that is required to provide a total oxygen makeup stream of about 2.0 lb/man-day. The carbon from the CO2 must be converted into a readily disposable or usable form. The results are given of initial experiments with a porous stainless steel cathode in a LiCl-KCl electrolyte with small additions of oxide, carbonate, and hydroxide.

Standards and guidelines for HIV prevention research: considerations for local context in the interpretation of global ethical standards.

PubMed

Haire, Bridget G; Folayan, Morenike Oluwatoyin; Brown, Brandon

2014-09-01

While international standards are important for conducting clinical research, they may require interpretation in particular contexts. Standard of care in HIV prevention research is now complicated, given that there are now two new biomedical prevention interventions - 'treatment-as-prevention', and pre-exposure prophylaxis--in addition to barrier protection, counselling, male circumcision and treatment of sexually transmissible infections. Proper standards of care must be considered with regard to both normative guidance and the circumstances of the particular stakeholders--the community, trial population, researchers and sponsors. In addition, the special circumstances of the lives of participants need to be acknowledged in designing trial protocols and study procedures. When researchers are faced with the dilemma of interpretation of international ethics guidelines and the realities of the daily lives of persons and their practices, the decisions of the local ethics committee become crucial. The challenge then becomes how familiar ethics committee members in these local settings are with these guidelines, and how their interpretation and use in the local context ensures the respect for persons and communities. It also includes justice and the fair selection of study participants without compromising data quality, and ensuring that the risks for study participants and their community do not outweigh the potential benefits.

What’s Important to the Patient?: Informational Needs of Patients Making Decisions about Hepatitis C Treatment

PubMed Central

Evon, Donna M.; Golin, Carol E.; Stoica, Teodora; Jones, Rachel; Willis, Sarah; Galanko, Joseph; Fried, Michael W.

2017-01-01

Background & Objectives Multiple treatment options with direct-acting antivirals (DAAs) are now available for hepatitis C virus (HCV). Study aims were to understand (1) The informational topics patients want to have to make informed treatment decisions; (2) The importance patients place on each topic; and (3) The topics patients prioritize as most important. Methods Mixed methods study utilizing two samples recruited from an academic liver center. Participants were not currently on treatment. Sample I (n=45) free-listed all informational topics deemed important to decision-making. Raw responses were coded into several broad and subcategories. Sample II (n=38) rated the importance of the subcategories from Sample I and ranked their highest priorities on two surveys, one containing topics for which sufficient research existed to inform patients (“static”), and the other containing topics that would require additional research. Results The topics listed by Sample I fell into 6 broad categories with 17 total subcategories. The most oft-cited informational topics were harms of treatment (100%), treatment benefits (62%) and treatment regimen details (84%). Sample II rated 16 of 17 subcategories as “pretty important’ or “extremely important.” Sample II prioritized (1) viral cure, (2) long-term survival, and (3) side effects on the survey of topics requiring additional research, and (1) liver disease, (2) lifestyle changes, and (3) medication details on the second survey of the most important static topics patients needed. Conclusions Patients weighed several informational topics to make an informed decision about HCV treatment. These findings lay the groundwork for future patient-centered outcomes research in HCV and patient-provider communication to enhance patients’ informed decision-making regarding DAA treatment options. PMID:27882509

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Additional survey requirements for steel-hull vessels...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42..., peaks, bilges, machinery spaces, and bunkers shall be examined to determine the condition of the framing...

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...

46 CFR 42.09-30 - Additional survey requirements for steel-hull vessels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Additional survey requirements for steel-hull vessels. 42.09-30 Section 42.09-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD...-30 Additional survey requirements for steel-hull vessels. (a) In addition to the requirements in § 42...