SSME Alternate Turbopump Development Program: Design verification specification for high-pressure fuel turbopump

NASA Technical Reports Server (NTRS)

1989-01-01

The design and verification requirements are defined which are appropriate to hardware at the detail, subassembly, component, and engine levels and to correlate these requirements to the development demonstrations which provides verification that design objectives are achieved. The high pressure fuel turbopump requirements verification matrix provides correlation between design requirements and the tests required to verify that the requirement have been met.

Do Stricter High School Graduation Requirements Improve College Readiness? ACT Working Paper Series. WP-2014-1

ERIC Educational Resources Information Center

Buddin, Richard; Croft, Michelle

2014-01-01

In recent years, state policymakers have increased high school course requirements--particularly in mathematics and science. This research examines whether stricter requirements have been effective at improving student outcomes. Student-level evidence from a state's recent reform suggests that higher requirements had little effect on trends in…

pelo Is Required for High Efficiency Viral Replication

PubMed Central

Wu, Xiurong; He, Wan-Ting; Tian, Shuye; Meng, Dan; Li, Yuanyue; Chen, Wanze; Li, Lisheng; Tian, Lili; Zhong, Chuan-Qi; Han, Felicia; Chen, Jianming; Han, Jiahuai

2014-01-01

Viruses hijack host factors for their high speed protein synthesis, but information about these factors is largely unknown. In searching for genes that are involved in viral replication, we carried out a forward genetic screen for Drosophila mutants that are more resistant or sensitive to Drosophila C virus (DCV) infection-caused death, and found a virus-resistant line in which the expression of pelo gene was deficient. Our mechanistic studies excluded the viral resistance of pelo deficient flies resulting from the known Drosophila anti-viral pathways, and revealed that pelo deficiency limits the high level synthesis of the DCV capsid proteins but has no or very little effect on the expression of some other viral proteins, bulk cellular proteins, and transfected exogenous genes. The restriction of replication of other types of viruses in pelo deficient flies was also observed, suggesting pelo is required for high level production of capsids of all kinds of viruses. We show that both pelo deficiency and high level DCV protein synthesis increase aberrant 80S ribosomes, and propose that the preferential requirement of pelo for high level synthesis of viral capsids is at least partly due to the role of pelo in dissociation of stalled 80S ribosomes and clearance of aberrant viral RNA and proteins. Our data demonstrated that pelo is a host factor that is required for high efficiency translation of viral capsids and targeting pelo could be a strategy for general inhibition of viral infection. PMID:24722736

L-Band Digital Aeronautical Communications System Engineering - Concepts of Use, Systems Performance, Requirements, and Architectures

NASA Technical Reports Server (NTRS)

Zelkin, Natalie; Henriksen, Stephen

2010-01-01

This NASA Contractor Report summarizes and documents the work performed to develop concepts of use (ConUse) and high-level system requirements and architecture for the proposed L-band (960 to 1164 MHz) terrestrial en route communications system. This work was completed as a follow-on to the technology assessment conducted by NASA Glenn Research Center and ITT for the Future Communications Study (FCS). ITT assessed air-to-ground (A/G) communications concepts of use and operations presented in relevant NAS-level, international, and NAS-system-level documents to derive the appropriate ConUse relevant to potential A/G communications applications and services for domestic continental airspace. ITT also leveraged prior concepts of use developed during the earlier phases of the FCS. A middle-out functional architecture was adopted by merging the functional system requirements identified in the bottom-up assessment of existing requirements with those derived as a result of the top-down analysis of ConUse and higher level functional requirements. Initial end-to-end system performance requirements were derived to define system capabilities based on the functional requirements and on NAS-SR-1000 and the Operational Performance Assessment conducted as part of the COCR. A high-level notional architecture of the L-DACS supporting A/G communication was derived from the functional architecture and requirements.

The effects of high dietary protein and nitrogen levels on the preformed methyl group requirement and methionine-induced growth depression in chicks.

PubMed

Pesti, G M; Benevenga, N J; Harper, A E; Sunde, M L

1981-02-01

The chick's choline and methionine requirements are both increased by high dietary protein level. Studies were conducted to test the hypothesis that the chicks' need for preformed methyl groups is increased by high protein diets (not methionine or choline per se). Chicks fed 25% isolated soybean protein (ISP) diets responded to methionine supplementation (162 vs 110 g gained in 14 days) but not to choline (119 g vs. 110 g), while those fed 50% ISP responded to either methionine (174 g vs. 126 g) or choline (181 g vs. 126 g) supplementation. Further, neither cystine nor homocystine could replace methionine in improving the growth of chicks fed the high protein diet. In other experiments, L-methionine and betaine HCl were found to alleviate the growth depression caused by excessive levels of L-glutamic acid. Excessive levels of L-methionine had a protective effect against growth depression caused by L-glutamate and diammonium citrate, and conversely, supplementary L-serine and sodium formate were not protective against glutamic acid- or arginine-induced growth depression. The results are consistent with the hypothesis that the preformed methyl group requirement is increased by high levels of dietary protein and excessive nitrogen from a single amino acid.

Importance of Requirements Analysis & Traceability to Improve Software Quality and Reduce Cost and Risk

NASA Technical Reports Server (NTRS)

Kapoor, Manju M.; Mehta, Manju

2010-01-01

The goal of this paper is to emphasize the importance of developing complete and unambiguous requirements early in the project cycle (prior to Preliminary Design Phase). Having a complete set of requirements early in the project cycle allows sufficient time to generate a traceability matrix. Requirements traceability and analysis are the key elements in improving verification and validation process, and thus overall software quality. Traceability can be most beneficial when the system changes. If changes are made to high-level requirements it implies that low-level requirements need to be modified. Traceability ensures that requirements are appropriately and efficiently verified at various levels whereas analysis ensures that a rightly interpreted set of requirements is produced.

Hierarchical design of an electro-hydraulic actuator based on robust LPV methods

NASA Astrophysics Data System (ADS)

Németh, Balázs; Varga, Balázs; Gáspár, Péter

2015-08-01

The paper proposes a hierarchical control design of an electro-hydraulic actuator, which is used to improve the roll stability of vehicles. The purpose of the control system is to generate a reference torque, which is required by the vehicle dynamic control. The control-oriented model of the actuator is formulated in two subsystems. The high-level hydromotor is described in a linear form, while the low-level spool valve is a polynomial system. These subsystems require different control strategies. At the high level, a linear parameter-varying control is used to guarantee performance specifications. At the low level, a control Lyapunov-function-based algorithm, which creates discrete control input values of the valve, is proposed. The interaction between the two subsystems is guaranteed by the spool displacement, which is control input at the high level and must be tracked at the low-level control. The spool displacement has physical constraints, which must also be incorporated into the control design. The robust design of the high-level control incorporates the imprecision of the low-level control as an uncertainty of the system.

System-Level Radiation Hardening

NASA Technical Reports Server (NTRS)

Ladbury, Ray

2014-01-01

Although system-level radiation hardening can enable the use of high-performance components and enhance the capabilities of a spacecraft, hardening techniques can be costly and can compromise the very performance designers sought from the high-performance components. Moreover, such techniques often result in a complicated design, especially if several complex commercial microcircuits are used, each posing its own hardening challenges. The latter risk is particularly acute for Commercial-Off-The-Shelf components since high-performance parts (e.g. double-data-rate synchronous dynamic random access memories - DDR SDRAMs) may require other high-performance commercial parts (e.g. processors) to support their operation. For these reasons, it is essential that system-level radiation hardening be a coordinated effort, from setting requirements through testing up to and including validation.

Application of a territorial-based filtering algorithm in turbomachinery blade design optimization

NASA Astrophysics Data System (ADS)

Bahrami, Salman; Khelghatibana, Maryam; Tribes, Christophe; Yi Lo, Suk; von Fellenberg, Sven; Trépanier, Jean-Yves; Guibault, François

2017-02-01

A territorial-based filtering algorithm (TBFA) is proposed as an integration tool in a multi-level design optimization methodology. The design evaluation burden is split between low- and high-cost levels in order to properly balance the cost and required accuracy in different design stages, based on the characteristics and requirements of the case at hand. TBFA is in charge of connecting those levels by selecting a given number of geometrically different promising solutions from the low-cost level to be evaluated in the high-cost level. Two test case studies, a Francis runner and a transonic fan rotor, have demonstrated the robustness and functionality of TBFA in real industrial optimization problems.

The Educational Implications of High Technology.

ERIC Educational Resources Information Center

Levin, Henry M.; Rumberger, Russell W.

The changes to be effected by high technology in both projected employment growth and existing jobs seem to require significant changes in the American educational system. However, government estimates for the period 1978-90 suggest that employment growth will favor jobs that require little or no training beyond the high school level (for…

Autonomy and relatedness in psychopathology and treatment: a cross-cultural formulation.

PubMed

Sato, T

2001-02-01

A cross-cultural view of psychopathology is proposed, contending that there are two basic systems of self-organization. These two systems of self-organization, labeled autonomy and relatedness, are essential to a person's well-being regardless of the culture or society to which the person belongs. The degree of autonomy and relatedness required to maintain mental health in a specific society is affected by cultural mores. People in collectivistic (primarily non-Western) cultures require high levels of relatedness and moderate levels of autonomy to maintain mental health. People in individualistic (primarily Western) cultures require high levels of autonomy and moderate levels of relatedness to maintain mental health. This view, based on a review of past work in various areas of psychology, is discussed in the context of various forms of psychotherapy existing in individualistic and collectivistic cultures.

Kickboxing review: anthropometric, psychophysiological and activity profiles and injury epidemiology

PubMed Central

Chaabene, H; Miarka, B; Franchini, E; Chamari, K; Cheour, F

2017-01-01

Kickboxing is one of the modern combat sports. The psychophysiological demands of a kickboxing competition require athletes to achieve high thresholds of several aspects of physical fitness. The aim of the current review is to critically analyse and appraise the kickboxer’s anthropometric, physiological, physical and psychological attributes with the activity profile and injury epidemiology in order to provide practical recommendations for training as well as new areas of scientific research. The available information shows that both amateur and elite-level male kickboxers are characterized by a higher proportion of mesomorphy with a well-developed muscle mass and low body fat percentage. While there is some variation in the maximum oxygen uptake of kickboxers, moderate to high cardio-respiratory levels are reported for these athletes. Regardless of kickboxers’ level, a high peak and mean anaerobic power output were reported. High-level kickboxing performance also requires well-developed muscle power in both the upper and lower limbs. Psychological factors contribute to success that requires high levels of self-confidence, motivation, dispositional hope and optimism, mental toughness/resiliency, and adaptive perfectionism. Psychological attributes also distinguished successful from less successful kickboxers. The activity-to-rest ratio was higher in elite (1:1) than both amateur and national-level (from 1:2 to 1:5) kickboxers, with no significant differences between rounds (round 1=1:4, and rounds 2 and 3=1:5) as well as between winners and losers in amateur and national-level simulated combats. These particular psychophysiological characteristics and performance aspects of kickboxers influence performance and could serve as guidance for training. Finally, kickboxing is characterized by chronic repetitive head trauma, which causes hypopituitarism due to traumatic brain injury (TBI). Future investigations into the physical, physiological and psychological characteristics related to age, gender and competitive levels of kickboxers are required to enrich the current knowledge and to help create the most suitable training programme. PMID:28566813

Kickboxing review: anthropometric, psychophysiological and activity profiles and injury epidemiology.

PubMed

Slimani, M; Chaabene, H; Miarka, B; Franchini, E; Chamari, K; Cheour, F

2017-06-01

Kickboxing is one of the modern combat sports. The psychophysiological demands of a kickboxing competition require athletes to achieve high thresholds of several aspects of physical fitness. The aim of the current review is to critically analyse and appraise the kickboxer's anthropometric, physiological, physical and psychological attributes with the activity profile and injury epidemiology in order to provide practical recommendations for training as well as new areas of scientific research. The available information shows that both amateur and elite-level male kickboxers are characterized by a higher proportion of mesomorphy with a well-developed muscle mass and low body fat percentage. While there is some variation in the maximum oxygen uptake of kickboxers, moderate to high cardio-respiratory levels are reported for these athletes. Regardless of kickboxers' level, a high peak and mean anaerobic power output were reported. High-level kickboxing performance also requires well-developed muscle power in both the upper and lower limbs. Psychological factors contribute to success that requires high levels of self-confidence, motivation, dispositional hope and optimism, mental toughness/resiliency, and adaptive perfectionism. Psychological attributes also distinguished successful from less successful kickboxers. The activity-to-rest ratio was higher in elite (1:1) than both amateur and national-level (from 1:2 to 1:5) kickboxers, with no significant differences between rounds (round 1=1:4, and rounds 2 and 3=1:5) as well as between winners and losers in amateur and national-level simulated combats. These particular psychophysiological characteristics and performance aspects of kickboxers influence performance and could serve as guidance for training. Finally, kickboxing is characterized by chronic repetitive head trauma, which causes hypopituitarism due to traumatic brain injury (TBI). Future investigations into the physical, physiological and psychological characteristics related to age, gender and competitive levels of kickboxers are required to enrich the current knowledge and to help create the most suitable training programme.

Explaining Gaps in Readiness for College-Level Math: The Role of High School Courses

ERIC Educational Resources Information Center

Long, Mark C.; Iatarola, Patrice; Conger, Dylan

2009-01-01

Despite increased requirements for high school graduation, almost one-third of the nation's college freshmen are unprepared for college-level math. The need for remediation is particularly high among students who are low income, Hispanic, and black. Female students are also less likely than males to be ready for college-level math. This article…

Requirements Flowdown for Prognostics and Health Management

NASA Technical Reports Server (NTRS)

Goebel, Kai; Saxena, Abhinav; Roychoudhury, Indranil; Celaya, Jose R.; Saha, Bhaskar; Saha, Sankalita

2012-01-01

Prognostics and Health Management (PHM) principles have considerable promise to change the game of lifecycle cost of engineering systems at high safety levels by providing a reliable estimate of future system states. This estimate is a key for planning and decision making in an operational setting. While technology solutions have made considerable advances, the tie-in into the systems engineering process is lagging behind, which delays fielding of PHM-enabled systems. The derivation of specifications from high level requirements for algorithm performance to ensure quality predictions is not well developed. From an engineering perspective some key parameters driving the requirements for prognostics performance include: (1) maximum allowable Probability of Failure (PoF) of the prognostic system to bound the risk of losing an asset, (2) tolerable limits on proactive maintenance to minimize missed opportunity of asset usage, (3) lead time to specify the amount of advanced warning needed for actionable decisions, and (4) required confidence to specify when prognosis is sufficiently good to be used. This paper takes a systems engineering view towards the requirements specification process and presents a method for the flowdown process. A case study based on an electric Unmanned Aerial Vehicle (e-UAV) scenario demonstrates how top level requirements for performance, cost, and safety flow down to the health management level and specify quantitative requirements for prognostic algorithm performance.

Teaching to the Test…or Testing to Teach: Exams Requiring Higher Order Thinking Skills Encourage Greater Conceptual Understanding

ERIC Educational Resources Information Center

Jensen, Jamie L.; McDaniel, Mark A.; Woodard, Steven M.; Kummer, Tyler A.

2014-01-01

In order to test the effect of exam-question level on fostering student conceptual understanding, low-level and high-level quizzes and exams were administered in two sections of an introductory biology course. Each section was taught in a high-level inquiry based style but was assigned either low-level questions (memory oriented) on the quizzes…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldston, W.T.

DOE issued Order 435.1, ''Radioactive Waste Management,'' on July 9, 1999 for immediate implementation. The requirements for Low Level Mixed, Transuranic, and High Level Waste have been completely rewritten. The entire DOE complex has been struggling with how to implement these new requirements within the one year required timeframe. This paper will chronicle the implementation strategy and actual results of the work to carry out that strategy at the Savannah River Site.

The Human Brain Does Not Need High Levels of Motivation to Learn a Foreign Language: Motivation Has Had Its Day

ERIC Educational Resources Information Center

Green, Kieran

2016-01-01

Language is nature in action and something humans do. This literature review presents evidence from the literature that suggests that learning a foreign language in a classroom situation does not require high levels of student motivation. It is instead suggested that high levels of motivation are needed to make progress when a teacher is using…

Alternatives Generation and Analysis for Heat Removal from High Level Waste Tanks

DOE Office of Scientific and Technical Information (OSTI.GOV)

WILLIS, W.L.

This document addresses the preferred combination of design and operational configurations to provide heat removal from high-level waste tanks during Phase 1 waste feed delivery to prevent the waste temperature from exceeding tank safety requirement limits. An interim decision for the preferred method to remove the heat from the high-level waste tanks during waste feed delivery operations is presented herein.

Mathematical Fundamentals of Probabilistic Semantics for High-Level Fusion

DTIC Science & Technology

2013-12-02

understanding of the fundamental aspects of uncertainty representation and reasoning that a theory of hard and soft high-level fusion must encompass...representation and reasoning that a theory of hard and soft high-level fusion must encompass. Successful completion requires an unbiased, in-depth...and soft information is the lack of a fundamental HLIF theory , backed by a consistent mathematical framework and supporting algorithms. Although there

Fault tolerant computer control for a Maglev transportation system

NASA Technical Reports Server (NTRS)

Lala, Jaynarayan H.; Nagle, Gail A.; Anagnostopoulos, George

1994-01-01

Magnetically levitated (Maglev) vehicles operating on dedicated guideways at speeds of 500 km/hr are an emerging transportation alternative to short-haul air and high-speed rail. They have the potential to offer a service significantly more dependable than air and with less operating cost than both air and high-speed rail. Maglev transportation derives these benefits by using magnetic forces to suspend a vehicle 8 to 200 mm above the guideway. Magnetic forces are also used for propulsion and guidance. The combination of high speed, short headways, stringent ride quality requirements, and a distributed offboard propulsion system necessitates high levels of automation for the Maglev control and operation. Very high levels of safety and availability will be required for the Maglev control system. This paper describes the mission scenario, functional requirements, and dependability and performance requirements of the Maglev command, control, and communications system. A distributed hierarchical architecture consisting of vehicle on-board computers, wayside zone computers, a central computer facility, and communication links between these entities was synthesized to meet the functional and dependability requirements on the maglev. Two variations of the basic architecture are described: the Smart Vehicle Architecture (SVA) and the Zone Control Architecture (ZCA). Preliminary dependability modeling results are also presented.

Collision Avoidance Functional Requirements for Step 1. Revision 6

NASA Technical Reports Server (NTRS)

2006-01-01

This Functional Requirements Document (FRD) describes the flow of requirements from the high level operational objectives down to the functional requirements specific to cooperative collision avoidance for high altitude, long endurance unmanned aircraft systems. These are further decomposed into performance and safety guidelines that are backed up by analysis or references to various documents or research findings. The FRD should be considered when establishing future policies, procedures, and standards pertaining to cooperative collision avoidance.

Extending enterprise architecture modelling with business goals and requirements

NASA Astrophysics Data System (ADS)

Engelsman, Wilco; Quartel, Dick; Jonkers, Henk; van Sinderen, Marten

2011-02-01

The methods for enterprise architecture (EA), such as The Open Group Architecture Framework, acknowledge the importance of requirements modelling in the development of EAs. Modelling support is needed to specify, document, communicate and reason about goals and requirements. The current modelling techniques for EA focus on the products, services, processes and applications of an enterprise. In addition, techniques may be provided to describe structured requirements lists and use cases. Little support is available however for modelling the underlying motivation of EAs in terms of stakeholder concerns and the high-level goals that address these concerns. This article describes a language that supports the modelling of this motivation. The definition of the language is based on existing work on high-level goal and requirements modelling and is aligned with an existing standard for enterprise modelling: the ArchiMate language. Furthermore, the article illustrates how EA can benefit from analysis techniques from the requirements engineering domain.

A microdisplay-based HUD for automotive applications: Backplane design, planarization, and optical implementation

NASA Astrophysics Data System (ADS)

Schuck, Miller Harry

Automotive head-up displays require compact, bright, and inexpensive imaging systems. In this thesis, a compact head-up display (HUD) utilizing liquid-crystal-on-silicon microdisplay technology is presented from concept to implementation. The thesis comprises three primary areas of HUD research: the specification, design and implementation of a compact HUD optical system, the development of a wafer planarization process to enhance reflective device brightness and light immunity and the design, fabrication and testing of an inexpensive 640 x 512 pixel active matrix backplane intended to meet the HUD requirements. The thesis addresses the HUD problem at three levels, the systems level, the device level, and the materials level. At the systems level, the optical design of an automotive HUD must meet several competing requirements, including high image brightness, compact packaging, video-rate performance, and low cost. An optical system design which meets the competing requirements has been developed utilizing a fully-reconfigurable reflective microdisplay. The design consists of two optical stages, the first a projector stage which magnifies the display, and a second stage which forms the virtual image eventually seen by the driver. A key component of the optical system is a diffraction grating/field lens which forms a large viewing eyebox while reducing the optical system complexity. Image quality biocular disparity and luminous efficacy were analyzed and results of the optical implementation are presented. At the device level, the automotive HUD requires a reconfigurable, video-rate, high resolution image source for applications such as navigation and night vision. The design of a 640 x 512 pixel active matrix backplane which meets the requirements of the HUD is described. The backplane was designed to produce digital field sequential color images at video rates utilizing fast switching liquid crystal as the modulation layer. The design methodology is discussed, and the example of a clock generator is described from design to implementation. Electrical and optical test results of the fabricated backplane are presented. At the materials level, a planarization method was developed to meet the stringent brightness requirements of automotive HUD's. The research efforts described here have resulted in a simple, low cost post-processing method for planarizing microdisplay substrates based on a spin-cast polymeric resin, benzocyclobutene (BCB). Six- fold reductions in substrate step height were accomplished with a single coating. Via masking and dry etching methods were developed. High reflectivity metal was deposited and patterned over the planarized substrate to produce high aperture pixel mirrors. The process is simple, rapid, and results in microdisplays better able to meet the stringent requirements of high brightness display systems. Methods and results of the post- processing are described.

Effect of physical workload and modality of information presentation on pattern recognition and navigation task performance by high-fit young males.

PubMed

Zahabi, Maryam; Zhang, Wenjuan; Pankok, Carl; Lau, Mei Ying; Shirley, James; Kaber, David

2017-11-01

Many occupations require both physical exertion and cognitive task performance. Knowledge of any interaction between physical demands and modalities of cognitive task information presentation can provide a basis for optimising performance. This study examined the effect of physical exertion and modality of information presentation on pattern recognition and navigation-related information processing. Results indicated males of equivalent high fitness, between the ages of 18 and 34, rely more on visual cues vs auditory or haptic for pattern recognition when exertion level is high. We found that navigation response time was shorter under low and medium exertion levels as compared to high intensity. Navigation accuracy was lower under high level exertion compared to medium and low levels. In general, findings indicated that use of the haptic modality for cognitive task cueing decreased accuracy in pattern recognition responses. Practitioner Summary: An examination was conducted on the effect of physical exertion and information presentation modality in pattern recognition and navigation. In occupations requiring information presentation to workers, who are simultaneously performing a physical task, the visual modality appears most effective under high level exertion while haptic cueing degrades performance.

What We Know about Developmental Education Outcomes. Research Overview

ERIC Educational Resources Information Center

Jaggars, Shanna Smith; Stacey, Georgia West

2014-01-01

Many recent high school graduates who enter community college are required to take remedial or developmental education courses before enrolling in college-level courses. Developmental courses essentially reteach high school- and junior high school-level content in reading, writing, and math. In some cases, students are referred to two or even…

Space Radiation Effects and Reliability Consideration for the Proposed Jupiter Europa Orbiter

NASA Technical Reports Server (NTRS)

Johnston, Allan

2011-01-01

The proposed Jupiter Europa Orbiter (JEO) mission to explore the Jovian moon Europa poses a number of challenges. The spacecraft must operate for about seven years during the transit time to the vicinity of Jupiter, and then endure unusually high radiation levels during exploration and orbiting phases. The ability to withstand usually high total dose levels is critical for the mission, along with meeting the high reliability standards for flagship NASA missions. Reliability of new microelectronic components must be sufficiently understood to meet overall mission requirements.The proposed Jupiter Europa Orbiter (JEO) mission to explore the Jovian moon Europa poses a number of challenges. The spacecraft must operate for about seven years during the transit time to the vicinity of Jupiter, and then endure unusually high radiation levels during exploration and orbiting phases. The ability to withstand usually high total dose levels is critical for the mission, along with meeting the high reliability standards for flagship NASA missions. Reliability of new microelectronic components must be sufficiently understood to meet overall mission requirements.

Space Vehicle Power System Comprised of Battery/Capacitor Combinations

NASA Technical Reports Server (NTRS)

Camarotte, C.; Lancaster, G. S.; Eichenberg, D.; Butler, S. M.; Miller, J. R.

2002-01-01

Recent improvements in energy densities of batteries open the possibility of using electric rather that hydraulic actuators in space vehicle systems. However, the systems usually require short-duration, high-power pulses. This power profile requires the battery system to be sized to meet the power requirements rather than stored energy requirements, often resulting in a large and inefficient energy storage system. Similar transient power applications have used a combination of two or more disparate energy storage technologies. For instance, placing a capacitor and a battery side-by-side combines the high energy density of a battery with the high power performance of a capacitor and thus can create a lighter and more compact system. A parametric study was performed to identify favorable scenarios for using capacitors. System designs were then carried out using equivalent circuit models developed for five commercial electrochemical capacitor products. Capacitors were sized to satisfy peak power levels and consequently "leveled" the power requirement of the battery, which can then be sized to meet system energy requirements. Simulation results clearly differentiate the performance offered by available capacitor products for the space vehicle applications.

A high-speed DAQ framework for future high-level trigger and event building clusters

NASA Astrophysics Data System (ADS)

Caselle, M.; Ardila Perez, L. E.; Balzer, M.; Dritschler, T.; Kopmann, A.; Mohr, H.; Rota, L.; Vogelgesang, M.; Weber, M.

2017-03-01

Modern data acquisition and trigger systems require a throughput of several GB/s and latencies of the order of microseconds. To satisfy such requirements, a heterogeneous readout system based on FPGA readout cards and GPU-based computing nodes coupled by InfiniBand has been developed. The incoming data from the back-end electronics is delivered directly into the internal memory of GPUs through a dedicated peer-to-peer PCIe communication. High performance DMA engines have been developed for direct communication between FPGAs and GPUs using "DirectGMA (AMD)" and "GPUDirect (NVIDIA)" technologies. The proposed infrastructure is a candidate for future generations of event building clusters, high-level trigger filter farms and low-level trigger system. In this paper the heterogeneous FPGA-GPU architecture will be presented and its performance be discussed.

46 CFR 62.35-50 - Tabulated monitoring and safety control requirements for specific systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) (9) Remote/auto fill level High Auto trip or overflow arrangement Hi. press. leakage level High Bilge... CL.3 W.T. doors Open/closed Fire detection Machinery spaces Space on fire (9) Fire main Pressure Low...

Individuals and the variation needed for high species diversity in forest trees

Treesearch

James S. Clark

2010-01-01

In the past, explanations for high species diversity have been sought at the species level. Theory shows that coexistence requires substantial differences between species, but species-level data rarely provide evidence for such differences. Using data from forests in the southeastern United States, I show here that variation evident at the individual level provides for...

High-sensitivity determination of Zn(II) and Cu(II) in vitro by fluorescence polarization

NASA Astrophysics Data System (ADS)

Thompson, Richard B.; Maliwal, Badri P.; Feliccia, Vincent; Fierke, Carol A.

1998-04-01

Recent work has suggested that free Cu(II) may play a role in syndromes such as Crohn's and Wilson's diseases, as well as being a pollutant toxic at low levels to shellfish and sheep. Similarly, Zn(II) has been implicated in some neural damage in the brain resulting from epilepsy and ischemia. Several high sensitivity methods exist for determining these ions in solution, including GFAAS, ICP-MS, ICP-ES, and electrochemical techniques. However, these techniques are generally slow and costly, require pretreatment of the sample, require complex instruments and skilled personnel, and are incapable of imaging at the cellular and subcellular level. To address these shortcomings we developed fluorescence polarization (anisotropy) biosensing methods for these ions which are very sensitivity, highly selective, require simple instrumentation and little pretreatment, and are inexpensive. Thus free Cu(II) or Zn(II) can be determined at picomolar levels by changes in fluorescence polarization, lifetime, or wavelength ratio using these methods; these techniques may be adapted to microscopy.

Sunlight-readable display technology: a dual-use case study

NASA Astrophysics Data System (ADS)

Blanchard, Randall D.

1996-05-01

This paper describes our vision of sunlight readable color display requirements, an alternate technology that offers a high level of performance, and how we implemented it for the military avionics display market. This knowledge base and product development experience was then applied with a comparable level of performance to commercial applications. The successful dual use of this technology for these two diverse markets is presented. Details of the technical commonality and a comparison of the design and performance differences are presented. A basis for specifying the required level of performance for a sunlight readable full color display is discussed. With the objective of providing a high level of image brightness and high ambient light rejection, a display architecture using collimated light is used. The resulting designs of two military cockpit display products, with contrast ratios above 20:1 in sunlight are shown. The performance of a commercial display providing several thousand foot- Lamberts of image brightness is presented.

33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

Code of Federal Regulations, 2012 CFR

2012-07-01

... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of this...

33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

Code of Federal Regulations, 2013 CFR

2013-07-01

... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of this...

33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

Code of Federal Regulations, 2014 CFR

2014-07-01

... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of this...

Foundational Security Principles for Medical Application Platforms* (Extended Abstract)

PubMed Central

Vasserman, Eugene Y.; Hatcliff, John

2014-01-01

We describe a preliminary set of security requirements for safe and secure next-generation medical systems, consisting of dynamically composable units, tied together through a real-time safety-critical middleware. We note that this requirement set is not the same for individual (stand-alone) devices or for electronic health record systems, and we must take care to define system-level requirements rather than security goals for components. The requirements themselves build on each other such that it is difficult or impossible to eliminate any one of the requirements and still achieve high-level security goals. PMID:25599096

Design considerations for the beamwaveguide retrofit of a ground antenna station

NASA Technical Reports Server (NTRS)

Veruttipong, T.; Withington, J.; Galindo-Israel, V.; Imbriale, W.; Bathker, D.

1987-01-01

A primary requirement of the NASA Deep Space Network (DSN) is to provide for optimal reception of very low signal levels. This requirement necessitates optimizing the antenna gain to the total system operating noise level quotient. Low overall system noise levels of 16 to 20 K are achieved by using cryogenically cooled preamplifiers closely coupled with an appropriately balanced antenna gain/spillover design. Additionally, high-power transmitters (up to 400 kW CW) are required for spacecraft emergency command and planetary radar experiments. The frequency bands allocated for deep space telemetry are narrow bands near 2.1 and 2.3 GHz (Ka-band), 7.1 and 8.4 GHz (X-band), and 32 and 34.5 GHz (Ka-band). In addition, planned operations for the Search for Extraterrestrial Intelligence (SETI) program require continuous low-noise receive coverage over the 1 to 10 GHz band. To summarize, DSN antennas must operate efficiently with low receive noise and high-power uplink over the 1 to 35 GHz band.

46 CFR 62.35-40 - Fuel systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Fuel systems. 62.35-40 Section 62.35-40 Shipping COAST... Requirements for Specific Types of Automated Vital Systems § 62.35-40 Fuel systems. (a) Level alarms. Where high or low fuel tank level alarms are required, they must be located to allow the operator adequate...

46 CFR 62.35-40 - Fuel systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Fuel systems. 62.35-40 Section 62.35-40 Shipping COAST... Requirements for Specific Types of Automated Vital Systems § 62.35-40 Fuel systems. (a) Level alarms. Where high or low fuel tank level alarms are required, they must be located to allow the operator adequate...

46 CFR 62.35-40 - Fuel systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Fuel systems. 62.35-40 Section 62.35-40 Shipping COAST... Requirements for Specific Types of Automated Vital Systems § 62.35-40 Fuel systems. (a) Level alarms. Where high or low fuel tank level alarms are required, they must be located to allow the operator adequate...

46 CFR 62.35-40 - Fuel systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Fuel systems. 62.35-40 Section 62.35-40 Shipping COAST... Requirements for Specific Types of Automated Vital Systems § 62.35-40 Fuel systems. (a) Level alarms. Where high or low fuel tank level alarms are required, they must be located to allow the operator adequate...

A discussion of higher order software concepts as they apply to functional requirements and specifications. [space shuttles and guidance

NASA Technical Reports Server (NTRS)

Hamilton, M.

1973-01-01

The entry guidance software functional requirements (requirements design phase), its architectural requirements (specifications design phase), and the entry guidance software verified code are discussed. It was found that the proper integration of designs at both the requirements and specifications levels are of high priority consideration.

The Interplay between Attentional Strategies and Language Processing in High-Functioning Adults with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Koolen, Sophieke; Vissers, Constance Th. W. M.; Hendriks, Angelique W. C. J.; Egger, Jos I. M.; Verhoeven, Ludo

2012-01-01

This study examined the hypothesis of an atypical interaction between attention and language in ASD. A dual-task experiment with three conditions was designed, in which sentences were presented that contained errors requiring attentional focus either at (a) low level, or (b) high level, or (c) both levels of language. Speed and accuracy for error…

10 CFR 60.162 - Physical requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Physical requirements. 60.162 Section 60.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Training and Certification of Personnel § 60.162 Physical requirements. The physical condition and...

10 CFR 60.162 - Physical requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Physical requirements. 60.162 Section 60.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Training and Certification of Personnel § 60.162 Physical requirements. The physical condition and...

10 CFR 60.162 - Physical requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Physical requirements. 60.162 Section 60.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Training and Certification of Personnel § 60.162 Physical requirements. The physical condition and...

10 CFR 60.162 - Physical requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Physical requirements. 60.162 Section 60.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Training and Certification of Personnel § 60.162 Physical requirements. The physical condition and...

Impact of High-Fidelity Simulation and Pharmacist-Specific Didactic Lectures in Addition to ACLS Provider Certification on Pharmacy Resident ACLS Performance.

PubMed

Bartel, Billie J

2014-08-01

This pilot study explored the use of multidisciplinary high-fidelity simulation and additional pharmacist-focused training methods in training postgraduate year 1 (PGY1) pharmacy residents to provide Advanced Cardiovascular Life Support (ACLS) care. Pharmacy resident confidence and comfort level were assessed after completing these training requirements. The ACLS training requirements for pharmacy residents were revised to include didactic instruction on ACLS pharmacology and rhythm recognition and participation in multidisciplinary high-fidelity simulation ACLS experiences in addition to ACLS provider certification. Surveys were administered to participating residents to assess the impact of this additional education on resident confidence and comfort level in cardiopulmonary arrest situations. The new ACLS didactic and simulation training requirements resulted in increased resident confidence and comfort level in all assessed functions. Residents felt more confident in all areas except providing recommendations for dosing and administration of medications and rhythm recognition after completing the simulation scenarios than with ACLS certification training and the didactic components alone. All residents felt the addition of lectures and simulation experiences better prepared them to function as a pharmacist in the ACLS team. Additional ACLS training requirements for pharmacy residents increased overall awareness of pharmacist roles and responsibilities and greatly improved resident confidence and comfort level in performing most essential pharmacist functions during ACLS situations. © The Author(s) 2013.

Durability and Life of Ceramic Matrix Composites in Combustion Environment

NASA Technical Reports Server (NTRS)

Tewari, Surendra

1997-01-01

It is now generally recognized that the next frontier in the commercial air travel will be achieved by an optimum combination of the concepts being used for the air and space transports. It will depend upon the new engines specifically designed to meet the demanding strength, temperature, environment and economy requirements. The successful development of an advanced propulsion system for a 21st Century High Speed Civil Transport will require key advances in the combustor system. Minimizing nitrous oxide (NO(x)) emission is critical, since the deleterious interaction within the ozone layer would occur at the proposed vehicle cruise level of about 75,000 feet. In order to achieve the low NOx levels an efficient combustor operating at controlled equivalence ratios and high combustion temperatures are required. This requires a combustor, whose one portion will be operating in an oxidizing environment while the other portion will operate in a reducing environment. This rather unusual requirement has introduced considerable challenge to the materials scientists and engineers, the development of material systems capable of long-life at high temperatures (up to 3000 F) in an oxidizing and/or reducing environment.

10 CFR 72.6 - License required; types of licenses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General... the receipt, handling, storage, and transfer of reactor-related GTCC are specific licenses. Any... hereby issued to receive title to and own spent fuel, high-level radioactive waste, or reactor-related...

10 CFR 72.6 - License required; types of licenses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General... the receipt, handling, storage, and transfer of reactor-related GTCC are specific licenses. Any... hereby issued to receive title to and own spent fuel, high-level radioactive waste, or reactor-related...

Planning Lessons for Students with Significant Disabilities in High School English Classes

ERIC Educational Resources Information Center

Apitz, Megan; Ruppar, Andrea; Roessler, Karli; Pickett, Kelly J.

2017-01-01

Students with significant disabilities have intellectual disability and require individualized modifications, adaptations, and supports to access grade-level content (National Center on Educational Outcomes, 2013). This group of students presents a unique challenge for literacy instruction, particularly at the high school level. Teachers must…

High-Level Overview of Data Needs for RE Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopez, Anthony

2016-12-22

This presentation provides a high level overview of analysis topics and associated data needs. Types of renewable energy analysis are grouped into two buckets: First, analysis for renewable energy potential, and second, analysis for other goals. Data requirements are similar but and they build upon one another.

10 CFR 60.8 - Information collection requirements: Approval.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Information collection requirements: Approval. 60.8 Section 60.8 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.8 Information collection requirements: Approval. (a) The...

75 FR 20582 - Record of Decision: Final Environmental Impact Statement for Decommissioning and/or Long-Term...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

... storage tanks and facilities used in the solidification of high-level radioactive waste, and any material... Act (Pub. L. 96-368, 42 U.S.C. 2021a). The WVDP Act requires DOE to demonstrate that the liquid high... take the following actions: 1. Solidify high-level radioactive waste by vitrification or such other...

Is It Really Possible to Test All Educationally Significant Achievements with High Levels of Reliability?

ERIC Educational Resources Information Center

Davis, Andrew

2015-01-01

PISA claims that it can extend its reach from its current core subjects of Reading, Science, Maths and problem-solving. Yet given the requirement for high levels of reliability for PISA, especially in the light of its current high stakes character, proposed widening of its subject coverage cannot embrace some important aspects of the social and…

Multi-Threaded Algorithms for GPGPU in the ATLAS High Level Trigger

NASA Astrophysics Data System (ADS)

Conde Muíño, P.; ATLAS Collaboration

2017-10-01

General purpose Graphics Processor Units (GPGPU) are being evaluated for possible future inclusion in an upgraded ATLAS High Level Trigger farm. We have developed a demonstrator including GPGPU implementations of Inner Detector and Muon tracking and Calorimeter clustering within the ATLAS software framework. ATLAS is a general purpose particle physics experiment located on the LHC collider at CERN. The ATLAS Trigger system consists of two levels, with Level-1 implemented in hardware and the High Level Trigger implemented in software running on a farm of commodity CPU. The High Level Trigger reduces the trigger rate from the 100 kHz Level-1 acceptance rate to 1.5 kHz for recording, requiring an average per-event processing time of ∼ 250 ms for this task. The selection in the high level trigger is based on reconstructing tracks in the Inner Detector and Muon Spectrometer and clusters of energy deposited in the Calorimeter. Performing this reconstruction within the available farm resources presents a significant challenge that will increase significantly with future LHC upgrades. During the LHC data taking period starting in 2021, luminosity will reach up to three times the original design value. Luminosity will increase further to 7.5 times the design value in 2026 following LHC and ATLAS upgrades. Corresponding improvements in the speed of the reconstruction code will be needed to provide the required trigger selection power within affordable computing resources. Key factors determining the potential benefit of including GPGPU as part of the HLT processor farm are: the relative speed of the CPU and GPGPU algorithm implementations; the relative execution times of the GPGPU algorithms and serial code remaining on the CPU; the number of GPGPU required, and the relative financial cost of the selected GPGPU. We give a brief overview of the algorithms implemented and present new measurements that compare the performance of various configurations exploiting GPGPU cards.

An Overview of the Space Shuttle Aerothermodynamic Design

NASA Technical Reports Server (NTRS)

Martin, Fred

2011-01-01

The Space Shuttle Thermal Protection System was one of the three areas that required the development of new technology. The talk discusses the pre-flight development of the aerothermodynamic environment which was based on Mach 8 wind tunnel data. A high level overview of the pre-flight heating rate predictions and comparison to the Orbiter Flight Test (OFT) data is presented, along with a discussion of the dramatic improvement in the state-of-the-art in aerothermodynamic capability that has been used to support the Shuttle Program. A high level review of the Orbiter aerothermodynamic design is discussed, along with improvements in Computational Fluid Dynamics and wind tunnel testing that was required for flight support during the last 30 years. The units have been removed from the plots, and the discussion is kept at a high level.

Assessing Requirements Quality through Requirements Coverage

NASA Technical Reports Server (NTRS)

Rajan, Ajitha; Heimdahl, Mats; Woodham, Kurt

2008-01-01

In model-based development, the development effort is centered around a formal description of the proposed software system the model. This model is derived from some high-level requirements describing the expected behavior of the software. For validation and verification purposes, this model can then be subjected to various types of analysis, for example, completeness and consistency analysis [6], model checking [3], theorem proving [1], and test-case generation [4, 7]. This development paradigm is making rapid inroads in certain industries, e.g., automotive, avionics, space applications, and medical technology. This shift towards model-based development naturally leads to changes in the verification and validation (V&V) process. The model validation problem determining that the model accurately captures the customer's high-level requirements has received little attention and the sufficiency of the validation activities has been largely determined through ad-hoc methods. Since the model serves as the central artifact, its correctness with respect to the users needs is absolutely crucial. In our investigation, we attempt to answer the following two questions with respect to validation (1) Are the requirements sufficiently defined for the system? and (2) How well does the model implement the behaviors specified by the requirements? The second question can be addressed using formal verification. Nevertheless, the size and complexity of many industrial systems make formal verification infeasible even if we have a formal model and formalized requirements. Thus, presently, there is no objective way of answering these two questions. To this end, we propose an approach based on testing that, when given a set of formal requirements, explores the relationship between requirements-based structural test-adequacy coverage and model-based structural test-adequacy coverage. The proposed technique uses requirements coverage metrics defined in [9] on formal high-level software requirements and existing model coverage metrics such as the Modified Condition and Decision Coverage (MC/DC) used when testing highly critical software in the avionics industry [8]. Our work is related to Chockler et al. [2], but we base our work on traditional testing techniques as opposed to verification techniques.

10 CFR 72.9 - Information collection requirements: OMB approval.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Information collection requirements: OMB approval. 72.9 Section 72.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C...

10 CFR 72.9 - Information collection requirements: OMB approval.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Information collection requirements: OMB approval. 72.9 Section 72.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C...

10 CFR 72.140 - Quality assurance requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Quality assurance requirements. 72.140 Section 72.140... SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.140 Quality assurance requirements. (a) Purpose. This subpart describes quality assurance...

10 CFR 72.140 - Quality assurance requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Quality assurance requirements. 72.140 Section 72.140... SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.140 Quality assurance requirements. (a) Purpose. This subpart describes quality assurance...

10 CFR 72.140 - Quality assurance requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Quality assurance requirements. 72.140 Section 72.140... SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.140 Quality assurance requirements. (a) Purpose. This subpart describes quality assurance...

10 CFR 72.140 - Quality assurance requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Quality assurance requirements. 72.140 Section 72.140... SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.140 Quality assurance requirements. (a) Purpose. This subpart describes quality assurance...

10 CFR 72.140 - Quality assurance requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Quality assurance requirements. 72.140 Section 72.140... SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.140 Quality assurance requirements. (a) Purpose. This subpart describes quality assurance...

10 CFR 60.3 - License required.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false License required. 60.3 Section 60.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.3 License required. (a) DOE shall not receive or possess source, special nuclear, or...

10 CFR 60.3 - License required.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false License required. 60.3 Section 60.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.3 License required. (a) DOE shall not receive or possess source, special nuclear, or...

10 CFR 60.3 - License required.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false License required. 60.3 Section 60.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.3 License required. (a) DOE shall not receive or possess source, special nuclear, or...

10 CFR 60.16 - Site characterization plan required.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Site characterization plan required. 60.16 Section 60.16 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Licenses Preapplication Review § 60.16 Site characterization plan required. Before proceeding to...

A modified dual-level algorithm for large-scale three-dimensional Laplace and Helmholtz equation

NASA Astrophysics Data System (ADS)

Li, Junpu; Chen, Wen; Fu, Zhuojia

2018-01-01

A modified dual-level algorithm is proposed in the article. By the help of the dual level structure, the fully-populated interpolation matrix on the fine level is transformed to a local supported sparse matrix to solve the highly ill-conditioning and excessive storage requirement resulting from fully-populated interpolation matrix. The kernel-independent fast multipole method is adopted to expediting the solving process of the linear equations on the coarse level. Numerical experiments up to 2-million fine-level nodes have successfully been achieved. It is noted that the proposed algorithm merely needs to place 2-3 coarse-level nodes in each wavelength per direction to obtain the reasonable solution, which almost down to the minimum requirement allowed by the Shannon's sampling theorem. In the real human head model example, it is observed that the proposed algorithm can simulate well computationally very challenging exterior high-frequency harmonic acoustic wave propagation up to 20,000 Hz.

No Child Left Behind and High School Astronomy

ERIC Educational Resources Information Center

Krumenaker, Larry

2009-01-01

Astronomy was a required subject in the first American secondary level schools, the academies of the 18th century. When these were supplanted a century later by public high schools, astronomy still was often required, subsumed into courses of Natural Philosophy. Reasons given at that time to support astronomy as a part of general education include…

The Use of Interactive Methods in the Educational Process of the Higher Education Institution

ERIC Educational Resources Information Center

Kutbiddinova, Rimma A.; Eromasova, Aleksandr? A.; Romanova, Marina A.

2016-01-01

The modernization of higher education and the transition to the new Federal Education Standards require a higher quality training of the graduates. The training of highly qualified specialists must meet strict requirements: a high level of professional competence, the developed communication skills, the ability to predict the results of one's own…

Influence of using challenging tasks in biology classrooms on students' cognitive knowledge structure: an empirical video study

NASA Astrophysics Data System (ADS)

Nawani, Jigna; Rixius, Julia; Neuhaus, Birgit J.

2016-08-01

Empirical analysis of secondary biology classrooms revealed that, on average, 68% of teaching time in Germany revolved around processing tasks. Quality of instruction can thus be assessed by analyzing the quality of tasks used in classroom discourse. This quasi-experimental study analyzed how teachers used tasks in 38 videotaped biology lessons pertaining to the topic 'blood and circulatory system'. Two fundamental characteristics used to analyze tasks include: (1) required cognitive level of processing (e.g. low level information processing: repetiition, summary, define, classify and high level information processing: interpret-analyze data, formulate hypothesis, etc.) and (2) complexity of task content (e.g. if tasks require use of factual, linking or concept level content). Additionally, students' cognitive knowledge structure about the topic 'blood and circulatory system' was measured using student-drawn concept maps (N = 970 students). Finally, linear multilevel models were created with high-level cognitive processing tasks and higher content complexity tasks as class-level predictors and students' prior knowledge, students' interest in biology, and students' interest in biology activities as control covariates. Results showed a positive influence of high-level cognitive processing tasks (β = 0.07; p < .01) on students' cognitive knowledge structure. However, there was no observed effect of higher content complexity tasks on students' cognitive knowledge structure. Presented findings encourage the use of high-level cognitive processing tasks in biology instruction.

Liquid cooled approaches for high density avionics

NASA Astrophysics Data System (ADS)

Levasseur, Robert

Next-generation aircraft will require avionics that provide greater system performance in a smaller volume, a process that requires highly developed thermal management techniques. To meet this need, a liquid-cooled approach has been developed to replace the conventional air-cooled approach for high-power applications. Liquid-cooled chassis and flow-through modules have been developed to limit junction temperatures to acceptable levels. Liquid cooling also permits emergency operation after loss of coolant for longer time intervals, which is desirable for flight-critical airborne applications. Activity to date has emphasized the development of chassis and modules that support the US Department of Defense's (DoD) two-level maintenance initiative as governed by the Joint Integrated Avionics Working Group (JIAWG).

The Response to High CO2 Levels Requires the Neuropeptide Secretion Component HID-1 to Promote Pumping Inhibition

PubMed Central

Sharabi, Kfir; Charar, Chayki; Friedman, Nurit; Mizrahi, Inbar; Zaslaver, Alon; Sznajder, Jacob I.; Gruenbaum, Yosef

2014-01-01

Carbon dioxide (CO2) is a key molecule in many biological processes; however, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Here we report that acute CO2 exposure leads to a rapid cessation in the contraction of the pharynx muscles in Caenorhabditis elegans. To uncover the molecular mechanisms underlying this response, we performed a forward genetic screen and found that hid-1, a key component in neuropeptide signaling, regulates this inhibition in muscle contraction. Surprisingly, we found that this hid-1-mediated pathway is independent of any previously known pathways controlling CO2 avoidance and oxygen sensing. In addition, animals with mutations in unc-31 and egl-21 (neuropeptide secretion and maturation components) show impaired inhibition of muscle contraction following acute exposure to high CO2 levels, in further support of our findings. Interestingly, the observed response in the pharynx muscle requires the BAG neurons, which also mediate CO2 avoidance. This novel hid-1-mediated pathway sheds new light on the physiological effects of high CO2 levels on animals at the organism-wide level. PMID:25101962

CrossTalk: The Journal of Defense Software Engineering. Volume 19, Number 12, December 2006

DTIC Science & Technology

2006-12-01

Feature-Oriented Domain Analysis ( FODA ) FODA is a domain analysis and engineer- ing method that focuses on developing reusable assets [9]. By examining...Eliciting Security Requirements This article describes an approach for doing trade-off analysis among requirements elicitation methods. by Dr. Nancy R...high-level requirements are addressed and met in the requirements work products. 3. Unclear requirements Mitigation Perform requirements analysis and

Cyber Foraging for Improving Survivability of Mobile Systems

DTIC Science & Technology

2016-02-10

environments—such as dynamic context, limited computing resources, disconnected- intermittent - limited (DIL) network connectivity, and high levels of stress...environments, such as dynamic context, limited computing resources, disconnected- intermittent -limited (DIL) network connectivity, and high levels of...Table 1: Mapping of Cloudlet Features to Survivability Requirements Threats Intermittent Cloudlet- Enterprise Connectivity Mobility Limited

Antecedent and Concurrent Psychosocial Skills That Support High Levels of Achievement within Talent Domains

ERIC Educational Resources Information Center

Olszewski-Kubilius, Paula; Subotnik, Rena F.; Worrell, Frank C.

2015-01-01

Motivation and emotional regulation are important for the sustained focused study and practice required for high levels of achievement and creative productivity in adulthood. Using the talent development model proposed by the authors as a framework, the authors discuss several important psychosocial skills based on the psychological research…

High School Mathematics: State-Level Curriculum Standards and Graduation Requirements

ERIC Educational Resources Information Center

Reys, Barbara J.; Dingman, Shannon; Nevels, Nevels; Teuscher, Dawn

2007-01-01

In a continuing effort to improve student-learning opportunities in mathematics, state departments of education have focused on articulating standards or learning goals at all levels, including high school mathematics. A review of K-8 mathematics curriculum standards (many of which have been published since 2002) compiled by staff from the Center…

Assessing Graduate Education Students' Propensity toward Academic Misconduct.

ERIC Educational Resources Information Center

Ferrell, Charlotte M.; Ferguson, William F.

Researchers have often noted the desirability of investigating the incidence of academic misconduct of college students who will be in employment fields requiring a high level of competence and/or a high level of personal integrity, such as elementary school and secondary school teachers. The Academic Misconduct Survey (AMS) developed by Charlotte…

Financial Literacy: Examining the Knowledge Transfer of Personal Finance from High School to College to Adulthood

ERIC Educational Resources Information Center

Yates, Dan; Ward, Chris

2011-01-01

Many states are now requiring high school students to be competent in the areas of economic and financial literacy. This is due to the recent escalation of bankruptcies, large credit card debt, and mortgage foreclosures in our society. This study examines how financial knowledge is transferred from the high school level to the college level and…

Parallel Optical Random Access Memory (PORAM)

NASA Technical Reports Server (NTRS)

Alphonse, G. A.

1989-01-01

It is shown that the need to minimize component count, power and size, and to maximize packing density require a parallel optical random access memory to be designed in a two-level hierarchy: a modular level and an interconnect level. Three module designs are proposed, in the order of research and development requirements. The first uses state-of-the-art components, including individually addressed laser diode arrays, acousto-optic (AO) deflectors and magneto-optic (MO) storage medium, aimed at moderate size, moderate power, and high packing density. The next design level uses an electron-trapping (ET) medium to reduce optical power requirements. The third design uses a beam-steering grating surface emitter (GSE) array to reduce size further and minimize the number of components.

10 CFR 60.7 - License not required for certain preliminary activities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain preliminary...

10 CFR 60.7 - License not required for certain preliminary activities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain preliminary...

Simulation of fiber optic liquid level sensor demodulation system

NASA Astrophysics Data System (ADS)

Yi, Cong-qin; Luo, Yun; Zhang, Zheng-ping

Measuring liquid level with high accuracy is an urgent requirement. This paper mainly focus on the demodulation system of fiber-optic liquid level sensor based on Fabry-Perot cavity, design and simulate the demodulation system by the single-chip simulation software.

32 CFR 901.5 - Academic examination requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Level 1 (Standard) Mathematics or Level II (Intensive) Mathematics. (Level 1 recommended for candidates without advanced high school mathematics.) (b) ACT. Candidates who elect to use the ACT tests must take the complete battery of tests: English, mathematics, social studies, and natural sciences. ...

Eight-Channel AC Magnetosusceptometer of Magnetic Nanoparticles for High-Throughput and Ultra-High-Sensitivity Immunoassay

PubMed Central

Chieh, Jen-Jie; Wei, Wen-Chun; Chen, Hsin-Hsein; Lee, Yen-Fu; Lin, Feng-Chun; Chiang, Ming-Hsien; Chiu, Ming-Jang; Horng, Herng-Er; Yang, Shieh-Yueh

2018-01-01

An alternating-current magnetosusceptometer of antibody-functionalized magnetic nanoparticles (MNPs) was developed for immunomagnetic reduction (IMR). A high-sensitivity, high-critical-temperature superconducting quantum interference device was used in the magnetosusceptometer. Minute levels of biomarkers of early-stage neurodegeneration diseases were detectable in serum, but measuring each biomarker required approximately 4 h. Hence, an eight-channel platform was developed in this study to fit minimal screening requirements for Alzheimer’s disease. Two consistent results were measured for three biomarkers, namely Aβ40, Aβ42, and tau protein, per human specimen. This paper presents the instrument configuration as well as critical characteristics, such as the low noise level variations among channels, a high signal-to-noise ratio, and the coefficient of variation for the biomarkers’ IMR values. The instrument’s ultrahigh sensitivity levels for the three biomarkers and the substantially shorter total measurement time in comparison with the previous single- and four-channels platforms were also demonstrated in this study. Thus, the eight-channel instrument may serve as a powerful tool for clinical high-throughput screening of Alzheimer’s disease. PMID:29601532

High-Threshold Fault-Tolerant Quantum Computation with Analog Quantum Error Correction

NASA Astrophysics Data System (ADS)

Fukui, Kosuke; Tomita, Akihisa; Okamoto, Atsushi; Fujii, Keisuke

2018-04-01

To implement fault-tolerant quantum computation with continuous variables, the Gottesman-Kitaev-Preskill (GKP) qubit has been recognized as an important technological element. However, it is still challenging to experimentally generate the GKP qubit with the required squeezing level, 14.8 dB, of the existing fault-tolerant quantum computation. To reduce this requirement, we propose a high-threshold fault-tolerant quantum computation with GKP qubits using topologically protected measurement-based quantum computation with the surface code. By harnessing analog information contained in the GKP qubits, we apply analog quantum error correction to the surface code. Furthermore, we develop a method to prevent the squeezing level from decreasing during the construction of the large-scale cluster states for the topologically protected, measurement-based, quantum computation. We numerically show that the required squeezing level can be relaxed to less than 10 dB, which is within the reach of the current experimental technology. Hence, this work can considerably alleviate this experimental requirement and take a step closer to the realization of large-scale quantum computation.

Contingency Contractor Optimization Phase 3 Sustainment Requirements Document Contingency Contractor Optimization Tool - Prototype

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bandlow, Alisa; Durfee, Justin David; Frazier, Christopher Rawls

2016-05-01

This requirements document serves as an addendum to the Contingency Contractor Optimization Phase 2, Requirements Document [1] and Phase 3 Requirements Document [2]. The Phase 2 Requirements document focused on the high-level requirements for the tool. The Phase 3 Requirements document provided more detailed requirements to which the engineering prototype was built in Phase 3. This document will provide detailed requirements for features and enhancements being added to the production pilot in the Phase 3 Sustainment.

FEDEF: A High Level Architecture Federate Development Framework

DTIC Science & Technology

2010-09-01

require code changes for operability between HLA specifications. Configuration of federate requirements such as publications, subscriptions, time ... management , and management protocol should occur outside of federate source code, allowing for federate reusability without code modification and re

Environmental monitoring of the orbiter payload bay and Orbiter Processing Facilities

NASA Technical Reports Server (NTRS)

Bartelson, D. W.; Johnson, A. M.

1985-01-01

Contamination control in the Orbiter Processing Facility (OPF) is studied. The clean level required in the OPF is generally clean, which means no residue, dirt, debris, or other extraneous contamination; various methods of maintaining this level of cleanliness are described. The monitoring and controlling of the temperature, relative humidity, and air quality in the OPF are examined. Additional modifications to the OPF to improve contamination control are discussed. The methods used to maintain the payload changeout room at a level of visually clean, no particulates are to be detected by the unaided eye, are described. The payload bay (PLB) must sustain the cleanliness level required for the specific Orbiter's mission; the three levels of clean are defined as: (1) standard, (2) sensitive, and (3) high sensitive. The cleaning and inspection verification required to achieve the desired cleanliness level on a variety of PLB surface types are examined.

Nutrient Requirements for High Stress Environments

DTIC Science & Technology

1988-04-20

Certain types of stress can cause increased nutrient requirements to maintain physiological or psychological performance levels; however, not all stress...elicits * this response and relatively few nutrient requirements are actually increased. Environmental stress sometimes causes increased energy...influence of "stress" is superimposed upon the dose-response curve. It is known that certain types of stress can result in an increased requirement for

AQBE — QBE Style Queries for Archetyped Data

NASA Astrophysics Data System (ADS)

Sachdeva, Shelly; Yaginuma, Daigo; Chu, Wanming; Bhalla, Subhash

Large-scale adoption of electronic healthcare applications requires semantic interoperability. The new proposals propose an advanced (multi-level) DBMS architecture for repository services for health records of patients. These also require query interfaces at multiple levels and at the level of semi-skilled users. In this regard, a high-level user interface for querying the new form of standardized Electronic Health Records system has been examined in this study. It proposes a step-by-step graphical query interface to allow semi-skilled users to write queries. Its aim is to decrease user effort and communication ambiguities, and increase user friendliness.

From Goal-Oriented Requirements to Event-B Specifications

NASA Technical Reports Server (NTRS)

Aziz, Benjamin; Arenas, Alvaro E.; Bicarregui, Juan; Ponsard, Christophe; Massonet, Philippe

2009-01-01

In goal-oriented requirements engineering methodologies, goals are structured into refinement trees from high-level system-wide goals down to fine-grained requirements assigned to specific software/ hardware/human agents that can realise them. Functional goals assigned to software agents need to be operationalised into specification of services that the agent should provide to realise those requirements. In this paper, we propose an approach for operationalising requirements into specifications expressed in the Event-B formalism. Our approach has the benefit of aiding software designers by bridging the gap between declarative requirements and operational system specifications in a rigorous manner, enabling powerful correctness proofs and allowing further refinements down to the implementation level. Our solution is based on verifying that a consistent Event-B machine exhibits properties corresponding to requirements.

Discovering system requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bahill, A.T.; Bentz, B.; Dean, F.F.

1996-07-01

Cost and schedule overruns are often caused by poor requirements that are produced by people who do not understand the requirements process. This report provides a high-level overview of the system requirements process, explaining types, sources, and characteristics of good requirements. System requirements, however, are seldom stated by the customer. Therefore, this report shows ways to help you work with your customer to discover the system requirements. It also explains terminology commonly used in the requirements development field, such as verification, validation, technical performance measures, and the various design reviews.

Silicon compilation: From the circuit to the system

NASA Astrophysics Data System (ADS)

Obrien, Keven

The methodology used for the compilation of silicon from a behavioral level to a system level is presented. The aim was to link the heretofore unrelated areas of high level synthesis and system level design. This link will play an important role in the development of future design automation tools as it will allow hardware/software co-designs to be synthesized. A design methodology that alllows, through the use of an intermediate representation, SOLAR, a System level Design Language (SDL), to be combined with a Hardware Description Language (VHDL) is presented. Two main steps are required in order to transform this specification into a synthesizable one. Firstly, a system level synthesis step including partitioning and communication synthesis is required in order to split the model into a set of interconnected subsystems, each of which will be processed by a high level synthesis tool. For this latter step AMICAL is used and this allows powerful scheduling techniques to be used, that accept very abstract descriptions of control flow dominated circuits as input, and interconnected RTL blocks that may feed existing logic-level synthesis tools to be generated.

A Social Approach to High-Level Context Generation for Supporting Context-Aware M-Learning

ERIC Educational Resources Information Center

Pan, Xu-Wei; Ding, Ling; Zhu, Xi-Yong; Yang, Zhao-Xiang

2017-01-01

In m-learning environments, context-awareness is for wide use where learners' situations are varied, dynamic and unpredictable. We are facing the challenge of requirements of both generality and depth in generating and processing high-level context. In this paper, we present a social approach which exploits social dynamics and social computing for…

46 CFR 129.570 - Overfill protection.

Code of Federal Regulations, 2014 CFR

2014-10-01

... alarm system or failure of electrical circuitry to the tank level sensor; and (3) Be able to be checked... that monitors the condition of the alarm circuitry and sensor. (d) The high-level alarm required by...

Requirements for the Entry Level Librarian.

ERIC Educational Resources Information Center

Creth, Sheila; Harders, Faith

1980-01-01

Presents the expectations of academic research libraries in the hiring of entry level librarians relative to academic and work experience. Results of a survey indicate that skills in management, automation, research, and writing are highly desirable. (RAA)

High salinity relay as a post-harvest processing method for reducing Vibrio vulnificus levels in oysters (Crassostrea virginica).

PubMed

Audemard, Corinne; Kator, Howard I; Reece, Kimberly S

2018-08-20

High salinity relay of Eastern oysters (Crassostrea virginica) was evaluated as a post-harvest processing (PHP) method for reducing Vibrio vulnificus. This approach relies on the exposure of oysters to natural high salinity waters and preserves a live product compared to previously approved PHPs. Although results of prior studies evaluating high salinity relay as a means to decrease V. vulnificus levels were promising, validation of this method as a PHP following approved guidelines is required. This study was designed to provide data for validation of this method following Food and Drug Administration (FDA) PHP validation guidelines. During each of 3 relay experiments, oysters cultured from 3 different Chesapeake Bay sites of contrasting salinities (10-21 psu) were relayed without acclimation to high salinity waters (31-33 psu) for up to 28 days. Densities of V. vulnificus and densities of total and pathogenic Vibrio parahaemolyticus (as tdh positive strains) were measured using an MPN-quantitative PCR approach. Overall, 9 lots of oysters were relayed with 6 exhibiting initial V. vulnificus >10,000/g. As recommended by the FDA PHP validation guidelines, these lots reached both the 3.52 log reduction and the <30 MPN/g densities requirements for V. vulnificus after 14 to 28 days of relay. Densities of total and pathogenic V. parahaemolyticus in relayed oysters were significantly lower than densities at the sites of origin suggesting an additional benefit associated with high salinity relay. While relay did not have a detrimental effect on oyster condition, oyster mortality levels ranged from 2 to 61% after 28 days of relay. Although the identification of the factors implicated in oyster mortality will require further examination, this study strongly supports the validation of high salinity relay as an effective PHP method to reduce levels of V. vulnificus in oysters to endpoint levels approved for human consumption. Copyright © 2018 Elsevier B.V. All rights reserved.

High-level waste storage tank farms/242-A evaporator standards/requirements identification document (S/RID), Vol. 7

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-04-01

This Requirements Identification Document (RID) describes an Occupational Health and Safety Program as defined through the Relevant DOE Orders, regulations, industry codes/standards, industry guidance documents and, as appropriate, good industry practice. The definition of an Occupational Health and Safety Program as specified by this document is intended to address Defense Nuclear Facilities Safety Board Recommendations 90-2 and 91-1, which call for the strengthening of DOE complex activities through the identification and application of relevant standards which supplement or exceed requirements mandated by DOE Orders. This RID applies to the activities, personnel, structures, systems, components, and programs involved in maintaining themore » facility and executing the mission of the High-Level Waste Storage Tank Farms.« less

77 FR 75838 - Regional Reliability Standard PRC-006-SERC-01; Automatic Underfrequency Load Shedding Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... approves the related violation risk factors (VRF), with one modification, violation severity levels (VSL... assigned to Requirement R6 from ``medium'' to ``high'' to make it consistent with the Commission's VRF... Commission's VRF guidelines and the violation risk factor for Requirement R9 of NERC Reliability Standard PRC...

Interactomes to Biological Phase Space: a call to begin thinking at a new level in computational biology.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davidson, George S.; Brown, William Michael

2007-09-01

Techniques for high throughput determinations of interactomes, together with high resolution protein collocalizations maps within organelles and through membranes will soon create a vast resource. With these data, biological descriptions, akin to the high dimensional phase spaces familiar to physicists, will become possible. These descriptions will capture sufficient information to make possible realistic, system-level models of cells. The descriptions and the computational models they enable will require powerful computing techniques. This report is offered as a call to the computational biology community to begin thinking at this scale and as a challenge to develop the required algorithms and codes tomore » make use of the new data.3« less

Advanced Materials and Component Development for Lithium-ion Cells for NASA Missions

NASA Technical Reports Server (NTRS)

Reid, Concha M.

2012-01-01

Human missions to Near Earth Objects, such as asteroids, planets, moons, libration points, and orbiting structures, will require safe, high specific energy, high energy density batteries to provide new or extended capabilities than are possible with today s state-of-the-art aerospace batteries. The National Aeronautics and Space Administration is developing advanced High Energy and Ultra High Energy lithium-ion cells to address these needs. In order to meet the performance goals, advanced, high-performing materials are required to provide improved performance at the component-level that contributes to performance at the integrated cell level. This paper will provide an update on the performance of experimental materials through the completion of two years of development. The progress of materials development, remaining challenges, and an outlook for the future of these materials in near term cell products will be discussed.

Maintaining consistency between planning hierarchies: Techniques and applications

NASA Technical Reports Server (NTRS)

Zoch, David R.

1987-01-01

In many planning and scheduling environments, it is desirable to be able to view and manipulate plans at different levels of abstraction, allowing the users the option of viewing and manipulating either a very detailed representation of the plan or a high-level more abstract version of the plan. Generating a detailed plan from a more abstract plan requires domain-specific planning/scheduling knowledge; the reverse process of generating a high-level plan from a detailed plan Reverse Plan Maintenance, or RPM) requires having the system remember the actions it took based on its domain-specific knowledge and its reasons for taking those actions. This reverse plan maintenance process is described as implemented in a specific planning and scheduling tool, The Mission Operations Planning Assistant (MOPA), as well as the applications of RPM to other planning and scheduling problems; emphasizing the knowledge that is needed to maintain the correspondence between the different hierarchical planning levels.

14 CFR Appendix A to Part 147 - Curriculum Requirements

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Instruction by lecture, demonstration, and discussion. (2) Level 2 requires: (i) Knowledge of general... basic operations. (iii) Instruction by lecture, demonstration, discussion, and limited practical.... (iii) Instruction by lecture, demonstration, discussion, and a high degree of practical application. (c...

14 CFR Appendix A to Part 147 - Curriculum Requirements

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Instruction by lecture, demonstration, and discussion. (2) Level 2 requires: (i) Knowledge of general... basic operations. (iii) Instruction by lecture, demonstration, discussion, and limited practical.... (iii) Instruction by lecture, demonstration, discussion, and a high degree of practical application. (c...

14 CFR Appendix A to Part 147 - Curriculum Requirements

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Instruction by lecture, demonstration, and discussion. (2) Level 2 requires: (i) Knowledge of general... basic operations. (iii) Instruction by lecture, demonstration, discussion, and limited practical.... (iii) Instruction by lecture, demonstration, discussion, and a high degree of practical application. (c...

Comments on settling chamber design for quiet, blowdown wind tunnels

NASA Technical Reports Server (NTRS)

Beckwith, I. E.

1981-01-01

Transfer of an existing continous circuit supersonic wind tunnel to Langley and its operation there as a blowdown tunnel is planned. Flow disturbance requirements in the supply section and methods for reducing the high level broad band acoustic disturbances present in typical blowdown tunnels are reviewed. Based on recent data and the analysis of two blowdown facilities at Langley, methods for reducing the total turbulence levels in the settling chamber, including both acoustic and vorticity modes, to less than one percent are recommended. The pertinent design details of the damping screens and honeycomb and the recommended minimum pressure drop across the porous components providing the required two orders of magnitude attenuation of acoustic noise levels are given. A suggestion for the support structure of these high pressure drop porous components is offered.

Reconfigurable Autonomy for Future Planetary Rovers

NASA Astrophysics Data System (ADS)

Burroughes, Guy

Extra-terrestrial Planetary rover systems are uniquely remote, placing constraints in regard to communication, environmental uncertainty, and limited physical resources, and requiring a high level of fault tolerance and resistance to hardware degradation. This thesis presents a novel self-reconfiguring autonomous software architecture designed to meet the needs of extraterrestrial planetary environments. At runtime it can safely reconfigure low-level control systems, high-level decisional autonomy systems, and managed software architecture. The architecture can perform automatic Verification and Validation of self-reconfiguration at run-time, and enables a system to be self-optimising, self-protecting, and self-healing. A novel self-monitoring system, which is non-invasive, efficient, tunable, and autonomously deploying, is also presented. The architecture was validated through the use-case of a highly autonomous extra-terrestrial planetary exploration rover. Three major forms of reconfiguration were demonstrated and tested: first, high level adjustment of system internal architecture and goal; second, software module modification; and third, low level alteration of hardware control in response to degradation of hardware and environmental change. The architecture was demonstrated to be robust and effective in a Mars sample return mission use-case testing the operational aspects of a novel, reconfigurable guidance, navigation, and control system for a planetary rover, all operating in concert through a scenario that required reconfiguration of all elements of the system.

Towards the formal specification of the requirements and design of a processor interface unit

NASA Technical Reports Server (NTRS)

Fura, David A.; Windley, Phillip J.; Cohen, Gerald C.

1993-01-01

Work to formally specify the requirements and design of a Processor Interface Unit (PIU), a single-chip subsystem providing memory interface, bus interface, and additional support services for a commercial microprocessor within a fault-tolerant computer system, is described. This system, the Fault-Tolerant Embedded Processor (FTEP), is targeted towards applications in avionics and space requiring extremely high levels of mission reliability, extended maintenance free operation, or both. The approaches that were developed for modeling the PIU requirements and for composition of the PIU subcomponents at high levels of abstraction are described. These approaches were used to specify and verify a nontrivial subset of the PIU behavior. The PIU specification in Higher Order Logic (HOL) is documented in a companion NASA contractor report entitled 'Towards the Formal Specification of the Requirements and Design of a Processor Interfacs Unit - HOL Listings.' The subsequent verification approach and HOL listings are documented in NASA contractor report entitled 'Towards the Formal Verification of the Requirements and Design of a Processor Interface Unit' and NASA contractor report entitled 'Towards the Formal Verification of the Requirements and Design of a Processor Interface Unit - HOL Listings.'

Noise control prediction for high-speed, propeller-driven aircraft

NASA Technical Reports Server (NTRS)

Wilby, J. F.; Rennison, D. C.; Wilby, E. G.; Marsh, A. H.

1980-01-01

An analytical study is described which explores add-on treatments and advanced concepts for the reduction of noise levels in three high-speed aircraft driven by propellers. Noise reductions of 25 to 28 dB are required to achieve a goal of an A-weighted sound level not greater than 80 dB. It is found that only a double-wall system, with a limp inner wall or trim panel, can achieve the required noise reductions. Weight penalties are estimated for the double-wall treatments. These penalties are 0.75% to 1.51% of the aircraft takeoff weight for the particular baseline designs selected.

Dynamic mobility applications open source application development portal task 6.1a : architecture and high-level design task 6.1b : list of requirements included in initial architecture and high-level design.

DOT National Transportation Integrated Search

2016-10-12

This document offers a detailed discussion of the systems functionality that was planned to be implemented. However, following the Agile Development methodology, during the course of system development, diligent decisions were made based on the la...

10 CFR 60.7 - License not required for certain preliminary activities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE... activities. The requirement for a license set forth in § 60.3(a) of this part is not applicable to the extent...

Design aspects of a solar array drive for spot, with a high platform stability objective

NASA Technical Reports Server (NTRS)

Cabillic, J.; Fournier, J. P.; Anstett, P.; Souliac, M.; Thomin, G.

1981-01-01

A solar array drive mechanism (MEGS) for the SPOT platform, which is a prototype of a multimission platform, is described. High-resolution cameras and other optical instruments are carried by the platform, requiring excellent platform stability in order to obtain high-quality pictures. Therefore, a severe requirement for the MEGS is the low level of disturbing torques it may generate considering the 0.6 times 10 to the minus 3 power deg/sec stability required. The mechanical design aspects aiming at reducing the mean friction torque, and therefore its fluctuations, are described as well as the method of compensation of the motor imperfections. It was concluded, however, that this is not sufficient to reach the stability requirement.

Personality and physiological correlates of performance decrement on a monotonous task requiring sustained attention.

DOT National Transportation Integrated Search

1973-12-01

The reductions in task load resulting from the increasing automation of air traffic control may actually increase the requirement for controllers to maintain high levels of sustained attention in order to detect infrequent system malfunctions. A prev...

High level waste storage tank farms/242-A evaporator standards/requirements identification document phase 1 assessment report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biebesheimer, E., Westinghouse Hanford Co.

This document, the Standards/Requirements Identification Document (S/RID) Phase I Assessment Report for the subject facility, represents the results of an Administrative Assessment to determine whether S/RID requirements are fully addressed by existing policies, plans or procedures. It contains; compliance status, remedial actions, and an implementing manuals report linking S/RID elements to requirement source to implementing manual and section.

High-dose anti-histamine use and risk factors in children with urticaria.

PubMed

Uysal, Pınar; Avcil, Sibelnur; Erge, Duygu

2016-12-01

The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria. The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria. The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p<0.0001). There was no difference between the two groups in terms of blood eosinophil and basophil counts, and serum total IgE levels (p>0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=-0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged ≥10 years (p<0.001, p=0.015). High UAS7 score (OR: 1.09; CI 95%: [1.03-1.15]) and basopenia (OR: 6.77; CI 95%: [2.01-22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria. The requirement of high-dose H1-antihistamines was higher with children's increasing age. Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines.

Monopropellant engine investigation for space shuttle reaction control system, volume 1

NASA Technical Reports Server (NTRS)

1975-01-01

The results are presented of an investigation to determine the capability of a monopropellant hydrazine thruster to meet the requirements specified for the space shuttle reaction control system (RCS). Of those requirements, the major concern was whether the 100,000 seconds life could be achieved at thrust levels within the specified range. Although burn times in excess of 200,000 seconds have been demonstrated at low thrust levels, the corresponding total impulse values have been substantially lower than that required for the space shuttle RCS. Two other areas of concern, involving the catalyst, were: (1) the effects of the relatively high vehicle vibration levels on catalyst attrition and (2) the effect of exposure of the catalyst to air during atmospheric reentry of the vehicle.

Applications of high average power nonlinear optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Velsko, S.P.; Krupke, W.F.

1996-02-05

Nonlinear optical frequency convertors (harmonic generators and optical parametric oscillators are reviewed with an emphasis on high average power performance and limitations. NLO materials issues and NLO device designs are discussed in reference to several emerging scientific, military and industrial commercial applications requiring {approx} 100 watt average power level in the visible and infrared spectral regions. Research efforts required to enable practical {approx} 100 watt class NLO based laser systems are identified.

Business Process Modelling is an Essential Part of a Requirements Analysis. Contribution of EFMI Primary Care Working Group.

PubMed

de Lusignan, S; Krause, P; Michalakidis, G; Vicente, M Tristan; Thompson, S; McGilchrist, M; Sullivan, F; van Royen, P; Agreus, L; Desombre, T; Taweel, A; Delaney, B

2012-01-01

To perform a requirements analysis of the barriers to conducting research linking of primary care, genetic and cancer data. We extended our initial data-centric approach to include socio-cultural and business requirements. We created reference models of core data requirements common to most studies using unified modelling language (UML), dataflow diagrams (DFD) and business process modelling notation (BPMN). We conducted a stakeholder analysis and constructed DFD and UML diagrams for use cases based on simulated research studies. We used research output as a sensitivity analysis. Differences between the reference model and use cases identified study specific data requirements. The stakeholder analysis identified: tensions, changes in specification, some indifference from data providers and enthusiastic informaticians urging inclusion of socio-cultural context. We identified requirements to collect information at three levels: micro- data items, which need to be semantically interoperable, meso- the medical record and data extraction, and macro- the health system and socio-cultural issues. BPMN clarified complex business requirements among data providers and vendors; and additional geographical requirements for patients to be represented in both linked datasets. High quality research output was the norm for most repositories. Reference models provide high-level schemata of the core data requirements. However, business requirements' modelling identifies stakeholder issues and identifies what needs to be addressed to enable participation.

A quick response four decade logarithmic high-voltage stepping supply

NASA Technical Reports Server (NTRS)

Doong, H.

1978-01-01

An improved high-voltage stepping supply, for space instrumentation is described where low power consumption and fast settling time between steps are required. The high-voltage stepping supply, utilizing an average power of 750 milliwatts, delivers a pair of mirror images with 64 level logarithmic outputs. It covers a four decade range of + or - 2500 to + or - 0.29 volts having an output stability of + or - 0.5 percent or + or - 20 millivolts for all line load and temperature variations. The supply provides a typical step setting time of 1 millisecond with 100 microseconds for the lower two decades. The versatile design features of the high-voltage stepping supply provides a quick response staircase generator as described or a fixed voltage with the option to change levels as required over large dynamic ranges without circuit modifications. The concept can be implemented up to + or - 5000 volts. With these design features, the high-voltage stepping supply should find numerous applications where charged particle detection, electro-optical systems, and high voltage scientific instruments are used.

HIGH-RESOLUTION DATASET OF URBAN CANOPY PARAMETERS FOR HOUSTON, TEXAS

EPA Science Inventory

Urban dispersion and air quality simulation models applied at various horizontal scales require different levels of fidelity for specifying the characteristics of the underlying surfaces. As the modeling scales approach the neighborhood level (~1 km horizontal grid spacing), the...

49 CFR 227.109 - Audiometric testing program.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Measurements of background sound pressure levels in the audiometric test room as required in appendix D of this... occupational noise in excess of the action level. Hearing protectors may be used as a substitute for the... railroad shall notify its employees of the need to avoid high levels of non-occupational noise exposure...

10 CFR 60.46 - Particular activities requiring license amendment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Particular activities requiring license amendment. 60.46 Section 60.46 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Licenses License Issuance and Amendment § 60.46 Particular activities...

10 CFR 60.46 - Particular activities requiring license amendment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Particular activities requiring license amendment. 60.46 Section 60.46 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Licenses License Issuance and Amendment § 60.46 Particular activities...

An Economic comparison of sludge irradiation and alternative methods of municipal sludge treatment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahlstrom, S.B.; McGuire, H.E.

1977-11-01

The relative economics of radiation treatment and other sludge treatment processes are reported. The desirability of radiation treatment is assessed in terms of cost and the quality of the treated sludge product. The major conclusions of this study are: radiation treatment is a high-level disinfection process. Therefore, it should only be considered if high levels of disinfection are required for widespread reuse of the sludge; the handling, transporting and pathogen growback problems associated with disinfected wet sludge makes it less attractive for reuse than dry sludge; radiation of composted sludge produces a product of similar quality at less cost thanmore » any thermal treatment and/or flash drying treatment option for situations where a high degree of disinfection is required; and heavy metal concerns, especially cadmium, may limit the reuse of sludge despite high disinfection levels. It is recommended that radiation treatment of sludge, particularly dry sludge, continue to be studied. A sensitivity analysis investigating the optimal conditions under which sludge irradiation operates should be instigated. Furthermore, costs of adding sludge irradiation to existing sludge treatment schemes should be determined.« less

The Effectiveness of the North Carolina Early Mathematics Placement Test in Preparing High School Students for College-Level Introductory Mathematics Courses

ERIC Educational Resources Information Center

Hilgoe, Ellen; Brinkley, Jason; Hattingh, Johannes; Bernhardt, Robert

2016-01-01

Since its establishment in 1996, the North Carolina Early Mathematics Placement Testing (NC EMPT) Program has provided a low stakes reality check of readiness for college-level mathematics to more than 600,000 high school students statewide. The program strives to help reduce the percentage of incoming college freshmen requiring mathematics…

"There's a Real Mix...It's Not All Doom and Gloom around Here!": Parents' Views on Raising Children in a Community Experiencing High Levels of Disadvantage

ERIC Educational Resources Information Center

Peppard, Judith

2009-01-01

In 2006 three primary schools and a community youth service "crossed borders" by forming a network to improve student educational achievement in a community experiencing high levels of disadvantage. Recognising that they lacked the capacity and resources required to counteract the numerous barriers to learning experienced by many of…

Description of waste pretreatment and interfacing systems dynamic simulation model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garbrick, D.J.; Zimmerman, B.D.

1995-05-01

The Waste Pretreatment and Interfacing Systems Dynamic Simulation Model was created to investigate the required pretreatment facility processing rates for both high level and low level waste so that the vitrification of tank waste can be completed according to the milestones defined in the Tri-Party Agreement (TPA). In order to achieve this objective, the processes upstream and downstream of the pretreatment facilities must also be included. The simulation model starts with retrieval of tank waste and ends with vitrification for both low level and high level wastes. This report describes the results of three simulation cases: one based on suggestedmore » average facility processing rates, one with facility rates determined so that approximately 6 new DSTs are required, and one with facility rates determined so that approximately no new DSTs are required. It appears, based on the simulation results, that reasonable facility processing rates can be selected so that no new DSTs are required by the TWRS program. However, this conclusion must be viewed with respect to the modeling assumptions, described in detail in the report. Also included in the report, in an appendix, are results of two sensitivity cases: one with glass plant water recycle steams recycled versus not recycled, and one employing the TPA SST retrieval schedule versus a more uniform SST retrieval schedule. Both recycling and retrieval schedule appear to have a significant impact on overall tank usage.« less

Monitoring Java Programs with Java PathExplorer

NASA Technical Reports Server (NTRS)

Havelund, Klaus; Rosu, Grigore; Clancy, Daniel (Technical Monitor)

2001-01-01

We present recent work on the development Java PathExplorer (JPAX), a tool for monitoring the execution of Java programs. JPAX can be used during program testing to gain increased information about program executions, and can potentially furthermore be applied during operation to survey safety critical systems. The tool facilitates automated instrumentation of a program's late code which will then omit events to an observer during its execution. The observer checks the events against user provided high level requirement specifications, for example temporal logic formulae, and against lower level error detection procedures, for example concurrency related such as deadlock and data race algorithms. High level requirement specifications together with their underlying logics are defined in the Maude rewriting logic, and then can either be directly checked using the Maude rewriting engine, or be first translated to efficient data structures and then checked in Java.

Thermal analysis of heat and power plant with high temperature reactor and intermediate steam cycle

NASA Astrophysics Data System (ADS)

Fic, Adam; Składzień, Jan; Gabriel, Michał

2015-03-01

Thermal analysis of a heat and power plant with a high temperature gas cooled nuclear reactor is presented. The main aim of the considered system is to supply a technological process with the heat at suitably high temperature level. The considered unit is also used to produce electricity. The high temperature helium cooled nuclear reactor is the primary heat source in the system, which consists of: the reactor cooling cycle, the steam cycle and the gas heat pump cycle. Helium used as a carrier in the first cycle (classic Brayton cycle), which includes the reactor, delivers heat in a steam generator to produce superheated steam with required parameters of the intermediate cycle. The intermediate cycle is provided to transport energy from the reactor installation to the process installation requiring a high temperature heat. The distance between reactor and the process installation is assumed short and negligable, or alternatively equal to 1 km in the analysis. The system is also equipped with a high temperature argon heat pump to obtain the temperature level of a heat carrier required by a high temperature process. Thus, the steam of the intermediate cycle supplies a lower heat exchanger of the heat pump, a process heat exchanger at the medium temperature level and a classical steam turbine system (Rankine cycle). The main purpose of the research was to evaluate the effectiveness of the system considered and to assess whether such a three cycle cogeneration system is reasonable. Multivariant calculations have been carried out employing the developed mathematical model. The results have been presented in a form of the energy efficiency and exergy efficiency of the system as a function of the temperature drop in the high temperature process heat exchanger and the reactor pressure.

An overview of very high level software design methods

NASA Technical Reports Server (NTRS)

Asdjodi, Maryam; Hooper, James W.

1988-01-01

Very High Level design methods emphasize automatic transfer of requirements to formal design specifications, and/or may concentrate on automatic transformation of formal design specifications that include some semantic information of the system into machine executable form. Very high level design methods range from general domain independent methods to approaches implementable for specific applications or domains. Applying AI techniques, abstract programming methods, domain heuristics, software engineering tools, library-based programming and other methods different approaches for higher level software design are being developed. Though one finds that a given approach does not always fall exactly in any specific class, this paper provides a classification for very high level design methods including examples for each class. These methods are analyzed and compared based on their basic approaches, strengths and feasibility for future expansion toward automatic development of software systems.

Ultra-Compact Transputer-Based Controller for High-Level, Multi-Axis Coordination

NASA Technical Reports Server (NTRS)

Zenowich, Brian; Crowell, Adam; Townsend, William T.

2013-01-01

The design of machines that rely on arrays of servomotors such as robotic arms, orbital platforms, and combinations of both, imposes a heavy computational burden to coordinate their actions to perform coherent tasks. For example, the robotic equivalent of a person tracing a straight line in space requires enormously complex kinematics calculations, and complexity increases with the number of servo nodes. A new high-level architecture for coordinated servo-machine control enables a practical, distributed transputer alternative to conventional central processor electronics. The solution is inherently scalable, dramatically reduces bulkiness and number of conductor runs throughout the machine, requires only a fraction of the power, and is designed for cooling in a vacuum.

Solving Geometric Problems by Using Algebraic Representation for Junior High School Level 3 in Van Hiele at Geometric Thinking Level

ERIC Educational Resources Information Center

Suwito, Abi; Yuwono, Ipung; Parta, I. Nengah; Irawati, Santi; Oktavianingtyas, Ervin

2016-01-01

This study aims to determine the ability of algebra students who have 3 levels van Hiele levels. Follow its framework Dindyal framework (2007). Students are required to do 10 algebra shaped multiple choice, then students work 15 about the geometry of the van Hiele level in the form of multiple choice questions. The question has been tested levels…

Backside illuminated CMOS-TDI line scan sensor for space applications

NASA Astrophysics Data System (ADS)

Cohen, Omer; Ofer, Oren; Abramovich, Gil; Ben-Ari, Nimrod; Gershon, Gal; Brumer, Maya; Shay, Adi; Shamay, Yaron

2018-05-01

A multi-spectral backside illuminated Time Delayed Integration Radiation Hardened line scan sensor utilizing CMOS technology was designed for continuous scanning Low Earth Orbit small satellite applications. The sensor comprises a single silicon chip with 4 independent arrays of pixels where each array is arranged in 2600 columns with 64 TDI levels. A multispectral optical filter whose spectral responses per array are adjustable per system requirement is assembled at the package level. A custom 4T Pixel design provides the required readout speed, low-noise, very low dark current, and high conversion gains. A 2-phase internally controlled exposure mechanism improves the sensor's dynamic MTF. The sensor high level of integration includes on-chip 12 bit per pixel analog to digital converters, on-chip controller, and CMOS compatible voltage levels. Thus, the power consumption and the weight of the supporting electronics are reduced, and a simple electrical interface is provided. An adjustable gain provides a Full Well Capacity ranging from 150,000 electrons up to 500,000 electrons per column and an overall readout noise per column of less than 120 electrons. The imager supports line rates ranging from 50 to 10,000 lines/sec, with power consumption of less than 0.5W per array. Thus, the sensor is characterized by a high pixel rate, a high dynamic range and a very low power. To meet a Latch-up free requirement RadHard architecture and design rules were utilized. In this paper recent electrical and electro-optical measurements of the sensor's Flight Models will be presented for the first time.

Interaction between different sports branches such as taekwondo, box, athletes and serum brain derived neurotrophic factor levels.

PubMed

Oztasyonar, Yunus

2017-04-01

This study aimed to compare serum brain-derived neurotrophic factor (BDNF) levels "which contributes in both neuron development/regeneration" between combat sport braches, which requires high attention and concentration and can lead micro and macro brain trauma, and athleticism, which requires durability in competition. The study design included 4 groups. Group 1 had sedentary participants, and group 2 athletes (middle and long runners) who exercised for two 2-hour daily training sessions 6 days a week. group 3 included boxers, and group 4 taekwondo fighters. We investigated changes in the blood BDNF levels of taekwondo fighters, boxers, and athletes before and after training and compared them among each other and with measurements of sedentary controls. All athletes had higher basal BDNF levels than sedentary participants. Boxers and taekwondo athletes had especially high basal BDNF levels. When we compared different sports branch each other Pre- and post- training BDNF values are ranked as follows: taekwondo > boxing > athletes > sedentary. In sport branches such as combat sports and athletes, serum BDNF levels have been demonstrated to be higher after training than before. In addition, serum BDNF levels were higher in taekwondo fighters and boxers than athletes. BDNF might have a role in the protection mechanism against brain damage or contributes in occurrence and maintenance of high attention and concentration especially among combat sports.

Financial viability of perinatal centers in the longer term, taking legislative requirements into account. An examination of the cost-revenue structure of a Level I perinatal center.

PubMed

Lux, Michael P; Kraml, Florian; Wagner, Stefanie; Hack, Carolin C; Schulze, Christine; Faschingbauer, Florian; Winkler, Mathias; Fasching, Peter A; Beckmann, Matthias W; Hildebrandt, Thomas

2013-01-01

Debate is currently taking place over minimum case numbers for the care of premature infants and neonates in Germany. As a result of the Federal Joint Committee (Gemeinsamer Bundesauschuss, G-BA) guidelines for the quality of structures, processes, and results, requiring high levels of staffing resources, Level I perinatal centers are increasingly becoming the focus for health-economics questions, specifically, debating whether Level I structures are financially viable. Using a multistep contribution margin analysis, the operating results for the Obstetrics Section at the University Perinatal Center of Franconia (Universitäts-Perinatalzentrum Franken) were calculated for the year 2009. Costs arising per diagnosis-related group (DRG) (separated into variable costs and fixed costs) and the corresponding revenue generated were compared for 4,194 in-patients and neonates, as well as for 3,126 patients in the outpatient ultrasound and pregnancy clinics. With a positive operating result of € 374,874.81, a Level I perinatal center on the whole initially appears to be financially viable, from the obstetrics point of view (excluding neonatology), with a high bed occupancy rate and a profitable case mix. By contrast, the costs of prenatal diagnostics, with a negative contribution margin II of € 50,313, cannot be covered. A total of 79.4% of DRG case numbers were distributed to five DRGs, all of which were associated with pregnancies and neonates with the lowest risk profiles. A Level I perinatal center is currently capable of covering its costs. However, the cost-revenue ratio is fragile due to the high requirements for staffing resources and numerous economic, social, and regional influencing factors.

High-Level Disinfection of Otorhinolaryngology Clinical Instruments: An Evaluation of the Efficacy and Cost-effectiveness of Instrument Storage.

PubMed

Yalamanchi, Pratyusha; Yu, Jason; Chandler, Laura; Mirza, Natasha

2018-01-01

Objectives Despite increasing interest in individual instrument storage, risk of bacterial cross-contamination of otorhinolaryngology clinic instruments has not been assessed. This study is the first to determine the clinical efficacy and cost-effectiveness of standard high-level disinfection and clinic instrument storage. Methods To assess for cross-contamination, surveillance cultures of otorhinolaryngology clinic instruments subject to standard high-level disinfection and storage were obtained at the start and end of the outpatient clinical workday. Rate of microorganism recovery was compared with cultures of instruments stored in individual peel packs and control cultures of contaminated instruments. Based on historical clinic data, the direct allocation method of cost accounting was used to determine aggregate raw material cost and additional labor hours required to process and restock peel-packed instruments. Results Among 150 cultures of standard high-level disinfected and co-located clinic instruments, 3 positive bacterial cultures occurred; 100% of control cultures were positive for bacterial species ( P < .001). There was no statistical difference between surveillance cultures obtained before and after the clinic day. While there was also no significant difference in rate of contamination between peel-packed and co-located instruments, peel packing all instruments requires 6250 additional labor hours, and conservative analyses place the cost of individual semicritical instrument storage at $97,852.50 per year. Discussion With in vitro inoculation of >200 otorhinolaryngology clinic instruments, this study demonstrates that standard high-level disinfection and storage are equally efficacious to more time-consuming and expensive individual instrument storage protocols, such as peel packing, with regard to bacterial contamination. Implications for Practice Standard high-level disinfection and storage are equally effective to labor-intensive and costly individual instrument storage protocols.

Representation and matching of knowledge to design digital systems

NASA Technical Reports Server (NTRS)

Jones, J. U.; Shiva, S. G.

1988-01-01

A knowledge-based expert system is described that provides an approach to solve a problem requiring an expert with considerable domain expertise and facts about available digital hardware building blocks. To design digital hardware systems from their high level VHDL (Very High Speed Integrated Circuit Hardware Description Language) representation to their finished form, a special data representation is required. This data representation as well as the functioning of the overall system is described.

High spectral resolution lidar based on quad mach zehnder interferometer for aerosols and wind measurements on board space missions

NASA Astrophysics Data System (ADS)

Mariscal, Jean-François; Bruneau, Didier; Pelon, Jacques; Van Haecke, Mathilde; Blouzon, Frédéric; Montmessin, Franck; Chepfer, Hélène

2018-04-01

We present the measurement principle and the optical design of a Quad Mach Zehnder (QMZ) interferometer as HSRL technique, allowing simultaneous measurements of particle backscattering and wind velocity. Key features of this concept is to operate with a multimodal laser and do not require any frequency stabilization. These features are relevant especially for space applications for which high technical readiness level is required.

Using high hydraulic conductivity nodes to simulate seepage lakes

USGS Publications Warehouse

Anderson, Mary P.; Hunt, Randall J.; Krohelski, James T.; Chung, Kuopo

2002-01-01

In a typical ground water flow model, lakes are represented by specified head nodes requiring that lake levels be known a priori. To remove this limitation, previous researchers assigned high hydraulic conductivity (K) values to nodes that represent a lake, under the assumption that the simulated head at the nodes in the high-K zone accurately reflects lake level. The solution should also produce a constant water level across the lake. We developed a model of a simple hypothetical ground water/lake system to test whether solutions using high-K lake nodes are sensitive to the value of K selected to represent the lake. Results show that the larger the contrast between the K of the aquifer and the K of the lake nodes, the smaller the error tolerance required for the solution to converge. For our test problem, a contrast of three orders of magnitude produced a head difference across the lake of 0.005 m under a regional gradient of the order of 10−3 m/m, while a contrast of four orders of magnitude produced a head difference of 0.001 m. The high-K method was then used to simulate lake levels in Pretty Lake, Wisconsin. Results for both the hypothetical system and the application to Pretty Lake compared favorably with results using a lake package developed for MODFLOW (Merritt and Konikow 2000). While our results demonstrate that the high-K method accurately simulates lake levels, this method has more cumbersome postprocessing and longer run times than the same problem simulated using the lake package.

Requirements for high-efficiency solar cells

NASA Technical Reports Server (NTRS)

Sah, C. T.

1986-01-01

Minimum recombination and low injection level are essential for high efficiency. Twenty percent AM1 efficiency requires a dark recombination current density of 2 x 10 to the minus 13th power A/sq cm and a recombination center density of less than 10 to the 10th power /cu cm. Recombination mechanisms at thirteen locations in a conventional single crystalline silicon cell design are reviewed. Three additional recombination locations are described at grain boundaries in polycrystalline cells. Material perfection and fabrication process optimization requirements for high efficiency are outlined. Innovative device designs to reduce recombination in the bulk and interfaces of single crystalline cells and in the grain boundary of polycrystalline cells are reviewed.

Understanding and Addressing Hepatitis C Virus Reinfection Among Men Who Have Sex with Men.

PubMed

Martin, Thomas C S; Rauch, Andri; Salazar-Vizcaya, Luisa; Martin, Natasha K

2018-06-01

Hepatitis C virus reinfection rates among men who have sex with men are high. Factors associated with infection point to varied sexual and drug-related risks that could be targeted for interventions to prevent infection/reinfection. Modeling indicates that tackling increasing incidence and high reinfection rates requires high levels of hepatitis C virus treatment combined with behavioral interventions. Enhanced testing strategies and prompt retreating of reinfection may be required to promptly diagnosed reinfections. Behavioral interventions studies addressing reinfection are required. Other interventions include traditional harm reduction interventions, adapted behavioral interventions, and interventions to prevent harms related to ChemSex and other risk factors. Copyright © 2018 Elsevier Inc. All rights reserved.

Physical oceanography from satellites: Currents and the slope of the sea surface

NASA Technical Reports Server (NTRS)

Sturges, W.

1974-01-01

A global scheme using satellite altimetry in conjunction with thermometry techniques provides for more accurate determinations of first order leveling networks by overcoming discrepancies between ocean leveling and land leveling methods. The high noise content in altimetry signals requires filtering or correction for tides, etc., as well as carefully planned sampling schemes.

Texting, Reading, and Other Daily Habits Associated with Adolescents' Literacy Levels

ERIC Educational Resources Information Center

Zebroff, Dmitri; Kaufman, David

2017-01-01

The level of functional illiteracy in the North American context, among others, appears to be reaching epidemic levels. The necessary linguistic and intellectual tools required to adequately function in our complex, highly-literate societies are not being sufficiently developed in many of our homes or schools. The findings from the present study…

Gas chromatographic analysis of trace impurities in chlorine trifluoride.

PubMed

Laurens, J B; Swinley, J M; de Coning, J P

2000-03-24

The gas chromatographic determination of trace gaseous impurities in highly reactive fluorinated gaseous matrices presents unique requirements to both equipment and techniques. Especially problematic are the gases normally present in ambient air namely oxygen and nitrogen. Analysing these gases at the low microl/l (ppm) level requires special equipment and this publication describes a custom-designed system utilising backflush column switching to protect the columns and detectors. A thermal conductivity detector with nickel filaments was used to determine ppm levels of impurities in ClF3.

77 FR 51686 - Specialty Crops; Import Regulations; New Pistachio Import Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... standards, thus promoting high quality product in the market place and fostering consumer satisfaction... designed to ensure that only high quality pistachios containing low levels of aflatoxin are shipped, thus promoting high quality product in the market place and fostering consumer satisfaction. The order, which was...

Ramifications of the Children's Surgery Verification Program for Patients and Hospitals.

PubMed

Baxter, Katherine J; Gale, Bonnie F; Travers, Curtis D; Heiss, Kurt F; Raval, Mehul V

2018-05-01

The American College of Surgeons in 2015 instituted the Children's Surgery Verification program delineating requirements for hospitals providing pediatric surgical care. Our purpose was to examine possible effects of the Children's Surgery Verification program by evaluating neonates undergoing high-risk operations. Using the Kid's Inpatient Database 2009, we identified infants undergoing operations for 5 high-risk neonatal conditions. We considered all children's hospitals and children's units Level I centers and considered all others Level II/III. We estimated the number of neonates requiring relocation and the additional distance traveled. We used propensity score adjusted logistic regression to model mortality at Level I vs Level II/III hospitals. Overall, 7,938 neonates were identified across 21 states at 91 Level I and 459 Level II/III hospitals. Based on our classifications, 2,744 (34.6%) patients would need to relocate to Level I centers. The median additional distance traveled was 6.6 miles. The maximum distance traveled varied by state, from <55 miles (New Jersey and Rhode Island) to >200 miles (Montana, Oregon, Colorado, and California). The adjusted odds of mortality at Level II/III vs Level I centers was 1.67 (95% CI 1.44 to 1.93). We estimate 1 life would be saved for every 32 neonates moved. Although this conservative estimate demonstrates that more than one-third of complex surgical neonates in 2009 would have needed to relocate under the Children's Surgery Verification program, the additional distance traveled is relatively short for most but not all, and this program might improve mortality. Local level ramifications of this novel national program require additional investigation. Copyright © 2018 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

Using Business Theory to Motivate Undergraduate Students in Goal Attainment: An Empirical Assessment and Model for High Level Motivation and Goal Attainment

ERIC Educational Resources Information Center

Anderson, Paul; Griego, Orlando V.; Stevens, Roxanne Helm

2010-01-01

Students at a private university in southern California took part in a study focusing on high level motivation and goal commitment. Using path analysis, this study mapped out two-paths. The first path to motivation and, therefore, goal commitment was through self-efficacy. The second path to goal commitment required a more supportive course.…

Human Systems Integration: Requirements and Functional Decomposition

NASA Technical Reports Server (NTRS)

Berson, Barry; Gershzohn, Gary; Boltz, Laura; Wolf, Russ; Schultz, Mike

2005-01-01

This deliverable was intended as an input to the Access 5 Policy and Simulation Integrated Product Teams. This document contains high-level pilot functionality for operations in the National Airspace System above FL430. Based on the derived pilot functions the associated pilot information and control requirements are given.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruiz, Steven Adriel

The following discussion contains a high-level description of methods used to implement software for data processing. It describes the required directory structures and file handling required to use Excel's Visual Basic for Applications programming language and how to identify shot, test and capture types to appropriately process data. It also describes how to interface with the software.

Aircraft Update Programmes. The Economical Alternative

DTIC Science & Technology

2000-04-01

will drive the desired level of integration but cost will determine the achieved level. Paper #15 by Christian Dedieu-Eric Loffler ( SAGEM SA) presented...requirements. The SAGEM SA upgrade concept allows one to match specifications ranging from basics performance enhancement, such as high accuracy navigation for

Protein level affects the relative lysine requirement of growing rainbow trout (Oncorhynchus mykiss) fry.

PubMed

Bodin, Noelie; Govaerts, Bernadette; Abboudi, Tarik; Detavernier, Christel; De Saeger, Sarah; Larondelle, Yvan; Rollin, Xavier

2009-07-01

The effect of two digestible protein levels (310 and 469 g/kg DM) on the relative lysine (Lys; g Lys/kg DM or g Lys/100 g protein) and the absolute Lys (g Lys intake/kg 0.75 per d) requirements was studied in rainbow trout fry using a dose-response trial. At each protein level, sixteen isoenergetic (22-23 MJ digestible energy/kg DM) diets were tested, involving a full range (2-70 g/kg DM) of sixteen Lys levels. Each diet was given to one group of sixty rainbow trout fry (mean initial body weight 0.78 g) reared at 15 degrees C for 31 feeding d. The Lys requirements were estimated based on the relationships between weight, protein, and Lys gains (g/kg 0.75 per d) and Lys concentration (g/kg DM or g/100 g protein) or Lys intake (g/kg 0.75 per d), using the broken-line model (BLM) and the non-linear four-parameter saturation kinetics model (SKM-4). Both the model and the response criterion chosen markedly impacted the relative Lys requirement. The relative Lys requirement for Lys gain of rainbow trout estimated with the BLM (and SKM-4 at 90 % of the maximum response) increased from 16.8 (19.6) g/kg DM at a low protein level to 23.4 (24.5) g/kg DM at a high protein level. However, the dietary protein content affected neither the absolute Lys requirement nor the relative Lys requirement expressed as g Lys/100 g protein nor the Lys requirement for maintenance (21 mg Lys/kg 0.75 per d).

XML-based data model and architecture for a knowledge-based grid-enabled problem-solving environment for high-throughput biological imaging.

PubMed

Ahmed, Wamiq M; Lenz, Dominik; Liu, Jia; Paul Robinson, J; Ghafoor, Arif

2008-03-01

High-throughput biological imaging uses automated imaging devices to collect a large number of microscopic images for analysis of biological systems and validation of scientific hypotheses. Efficient manipulation of these datasets for knowledge discovery requires high-performance computational resources, efficient storage, and automated tools for extracting and sharing such knowledge among different research sites. Newly emerging grid technologies provide powerful means for exploiting the full potential of these imaging techniques. Efficient utilization of grid resources requires the development of knowledge-based tools and services that combine domain knowledge with analysis algorithms. In this paper, we first investigate how grid infrastructure can facilitate high-throughput biological imaging research, and present an architecture for providing knowledge-based grid services for this field. We identify two levels of knowledge-based services. The first level provides tools for extracting spatiotemporal knowledge from image sets and the second level provides high-level knowledge management and reasoning services. We then present cellular imaging markup language, an extensible markup language-based language for modeling of biological images and representation of spatiotemporal knowledge. This scheme can be used for spatiotemporal event composition, matching, and automated knowledge extraction and representation for large biological imaging datasets. We demonstrate the expressive power of this formalism by means of different examples and extensive experimental results.

Prototype development and demonstration for response, emergency staging, communications, uniform management, and evacuation (R.E.S.C.U.M.E.) : R.E.S.C.U.M.E. final functional and performance requirements.

DOT National Transportation Integrated Search

2014-01-01

This document provides the high-level functional and performance requirements for the Prototype Development and Demonstration of a R.E.S.C.U.M.E. system. The requirements included in this document are based upon those that can be found in previous R....

The Future of the U.S. Workforce: The Limited Career Prospects for High School Graduates without Additional Education and Training

ERIC Educational Resources Information Center

Achieve, Inc., 2012

2012-01-01

The U.S. economy has undergone dramatic changes in recent decades. Jobs that required limited skills--but still paid a family-supporting wage--have disappeared and increasingly have been replaced with jobs that either require higher levels of education and skills "or" require little education and training but offer no pathways to careers…

Small-Scale Waste-to-Energy Technology for Contingency Bases

DTIC Science & Technology

2012-05-24

Expedient, No Waste Sorting Technology Readiness Level High Fuel Demand Water Required Steam Infrastructure Required Air Emissions Gasification ...Full gasification system • Costs $26K • GM Industrial Engine (GM 4 Cylinder, 3.00 L) • MeccAlte Generator Head • Imbert type downdraft reactor...Solid waste volume reduction − Response to waste streams  biomass , refuse-derived fuel, shredded waste − Operation and maintenance requirements

Ontology-Based High-Level Context Inference for Human Behavior Identification

PubMed Central

Villalonga, Claudia; Razzaq, Muhammad Asif; Khan, Wajahat Ali; Pomares, Hector; Rojas, Ignacio; Lee, Sungyoung; Banos, Oresti

2016-01-01

Recent years have witnessed a huge progress in the automatic identification of individual primitives of human behavior, such as activities or locations. However, the complex nature of human behavior demands more abstract contextual information for its analysis. This work presents an ontology-based method that combines low-level primitives of behavior, namely activity, locations and emotions, unprecedented to date, to intelligently derive more meaningful high-level context information. The paper contributes with a new open ontology describing both low-level and high-level context information, as well as their relationships. Furthermore, a framework building on the developed ontology and reasoning models is presented and evaluated. The proposed method proves to be robust while identifying high-level contexts even in the event of erroneously-detected low-level contexts. Despite reasonable inference times being obtained for a relevant set of users and instances, additional work is required to scale to long-term scenarios with a large number of users. PMID:27690050

High pressure processing's potential to inactivate norovirus and other fooodborne viruses

USDA-ARS?s Scientific Manuscript database

High pressure processing (HPP) can inactivate human norovirus. However, all viruses are not equally susceptible to HPP. Pressure treatment parameters such as required pressure levels, initial pressurization temperatures, and pressurization times substantially affect inactivation. How food matrix ...

Extracting and shaping the light of OLED devices

NASA Astrophysics Data System (ADS)

Riedel, Daniel; Dlugosch, Julian; Wehlus, Thomas; Brabec, Christoph

2015-09-01

Before the market entry of organic light emitting diodes (OLEDs) into the field of general illumination can occur, limitations in lifetime, luminous efficacy and cost must be overcome. Additional requirements for OLEDs used for general illumination may be imposed by workplace glare reduction requirements, which demand limited luminance for high viewing angles. These requirements contrast with the typical lambertian emission characteristics of OLEDs, which result in the same luminance levels for all emission angles. As a consequence, without additional measures glare reduction could limit the maximum possible luminance of lambertian OLEDs to relatively low levels. However, high luminance levels are still desirable in order to obtain high light output. We are presenting solutions to overcome this dilemma. Therefore this work is focused on light-shaping structures for OLEDs with an internal light extraction layer. Simulations of beam-shaping structures and shapes are presented, followed by experimental measurements to verify the simulations of the most promising structures. An investigation of the loss channels has been carried out and the overall optical system efficiency was evaluated for all structures. The most promising light shaping structures achieve system efficiencies up to 80%. Finally, a general illumination application scenario has been simulated. The number of OLEDs needed to illuminate an office room has been deduced from this scenario. By using light-shaping structures for OLEDs, the number of OLEDs needed to reach the mandatory illuminance level for a workplace environment can be reduced to one third compared to lambertian OLEDs.

Investigation of High-alpha Lateral-directional Control Power Requirements for High-performance Aircraft

NASA Technical Reports Server (NTRS)

Foster, John V.; Ross, Holly M.; Ashley, Patrick A.

1993-01-01

Designers of the next-generation fighter and attack airplanes are faced with the requirements of good high-angle-of-attack maneuverability as well as efficient high speed cruise capability with low radar cross section (RCS) characteristics. As a result, they are challenged with the task of making critical design trades to achieve the desired levels of maneuverability and performance. This task has highlighted the need for comprehensive, flight-validated lateral-directional control power design guidelines for high angles of attack. A joint NASA/U.S. Navy study has been initiated to address this need and to investigate the complex flight dynamics characteristics and controls requirements for high-angle-of-attack lateral-directional maneuvering. A multi-year research program is underway which includes ground-based piloted simulation and flight validation. This paper will give a status update of this program that will include a program overview, description of test methodology and preliminary results.

Investigation of high-alpha lateral-directional control power requirements for high-performance aircraft

NASA Technical Reports Server (NTRS)

Foster, John V.; Ross, Holly M.; Ashley, Patrick A.

1993-01-01

Designers of the next-generation fighter and attack airplanes are faced with the requirements of good high angle-of-attack maneuverability as well as efficient high speed cruise capability with low radar cross section (RCS) characteristics. As a result, they are challenged with the task of making critical design trades to achieve the desired levels of maneuverability and performance. This task has highlighted the need for comprehensive, flight-validated lateral-directional control power design guidelines for high angles of attack. A joint NASA/U.S. Navy study has been initiated to address this need and to investigate the complex flight dynamics characteristics and controls requirements for high angle-of-attack lateral-directional maneuvering. A multi-year research program is underway which includes groundbased piloted simulation and flight validation. This paper will give a status update of this program that will include a program overview, description of test methodology and preliminary results.

High-Voltage Clock Driver for Photon-Counting CCD Characterization

NASA Technical Reports Server (NTRS)

Baker, Robert

2013-01-01

A document discusses the CCD97 from e2v technologies as it is being evaluated at Goddard Space Flight Center's Detector Characterization Laboratory (DCL) for possible use in ultra-low background noise space astronomy applications, such as Terrestrial Planet Finder Coronagraph (TPF-C). The CCD97 includes a photoncounting mode where the equivalent output noise is less than one electron. Use of this mode requires a clock signal at a voltage level greater than the level achievable by the existing CCD (charge-coupled-device) electronics. A high-voltage waveform generator has been developed in code 660/601 to support the CCD97 evaluation. The unit generates required clock waveforms at voltage levels from -20 to +50 V. It deals with standard and arbitrary waveforms and supports pixel rates from 50 to 500 kHz. The system is designed to interface with existing Leach CCD electronics.

Combat aircraft operations: Training requirements for the German Air Force tactical flying units and the noise problem

NASA Astrophysics Data System (ADS)

Jertz, W.

1992-04-01

The deterrence potential of an Air Force, and by that the capability to fulfill their mission in times of war, relies on threat oriented training in peacetime. Low level flying is a major tactical means to help aircrews reduce the anticipated threat imposed to them by enemy air defence systems to an acceptable degree. The demand for this capability applies also to air defence tasks against attacking fighter bombers. Military low level flying requires a high degree of proficiency, which can only be reached and maintained by constant training. A high performance level is then the key to air power. The possibilities for this kind of necessary training are restricted by superior demands concerning, amongst others, flying safety and environmental reasons. Too intensive restrictions might reduce the fighting capability of the wings to such an extent, that mission fulfillment could be seriously endangered.

Evaluation of components, subsystems, and networks for high rate, high frequency space communications

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Ivancic, William D.; Zuzek, John E.

1991-01-01

The development of new space communications technologies by NASA has included both commercial applications and space science requirements. NASA's Systems Integration, Test and Evaluation (SITE) Space Communication System Simulator is a hardware based laboratory simulator for evaluating space communications technologies at the component, subsystem, system, and network level, geared toward high frequency, high data rate systems. The SITE facility is well-suited for evaluation of the new technologies required for the Space Exploration Initiative (SEI) and advanced commercial systems. Described here are the technology developments and evaluation requirements for current and planned commercial and space science programs. Also examined are the capabilities of SITE, the past, present and planned future configurations of the SITE facility, and applications of SITE to evaluation of SEI technology.

Low-Flow Extracorporeal Carbon Dioxide Removal Using the Hemolung Respiratory Dialysis System® to Facilitate Lung-Protective Mechanical Ventilation in Acute Respiratory Distress Syndrome.

PubMed

Akkanti, Bindu; Rajagopal, Keshava; Patel, Kirti P; Aravind, Sangeeta; Nunez-Centanu, Emmanuel; Hussain, Rahat; Shabari, Farshad Raissi; Hofstetter, Wayne L; Vaporciyan, Ara A; Banjac, Igor S; Kar, Biswajit; Gregoric, Igor D; Loyalka, Pranav

2017-06-01

Extracorporeal carbon dioxide removal (ECCO 2 R) permits reductions in alveolar ventilation requirements that the lungs would otherwise have to provide. This concept was applied to a case of hypercapnia refractory to high-level invasive mechanical ventilator support. We present a case of an 18-year-old man who developed post-pneumonectomy acute respiratory distress syndrome (ARDS) after resection of a mediastinal germ cell tumor involving the left lung hilum. Hypercapnia and hypoxemia persisted despite ventilator support even at traumatic levels. ECCO 2 R using a miniaturized system was instituted and provided effective carbon dioxide elimination. This facilitated establishment of lung-protective ventilator settings and lung function recovery. Extracorporeal lung support increasingly is being applied to treat ARDS. However, conventional extracorporeal membrane oxygenation (ECMO) generally involves using large cannulae capable of carrying high flow rates. A subset of patients with ARDS has mixed hypercapnia and hypoxemia despite high-level ventilator support. In the absence of profound hypoxemia, ECCO 2 R may be used to reduce ventilator support requirements to lung-protective levels, while avoiding risks associated with conventional ECMO.

Joint digital signal processing for superchannel coherent optical communication systems.

PubMed

Liu, Cheng; Pan, Jie; Detwiler, Thomas; Stark, Andrew; Hsueh, Yu-Ting; Chang, Gee-Kung; Ralph, Stephen E

2013-04-08

Ultra-high-speed optical communication systems which can support ≥ 1Tb/s per channel transmission will soon be required to meet the increasing capacity demand. However, 1Tb/s over a single carrier requires either or both a high-level modulation format (i.e. 1024QAM) and a high baud rate. Alternatively, grouping a number of tightly spaced "sub-carriers" to form a terabit superchannel increases channel capacity while minimizing the need for high-level modulation formats and high baud rate, which may allow existing formats, baud rate and components to be exploited. In ideal Nyquist-WDM superchannel systems, optical subcarriers with rectangular spectra are tightly packed at a channel spacing equal to the baud rate, thus achieving the Nyquist bandwidth limit. However, in practical Nyquist-WDM systems, precise electrical or optical control of channel spectra is required to avoid strong inter-channel interference (ICI). Here, we propose and demonstrate a new "super receiver" architecture for practical Nyquist-WDM systems, which jointly detects and demodulates multiple channels simultaneously and mitigates the penalties associated with the limitations of generating ideal Nyquist-WDM spectra. Our receiver-side solution relaxes the filter requirements imposed on the transmitter. Two joint DSP algorithms are developed for linear ICI cancellation and joint carrier-phase recovery. Improved system performance is observed with both experimental and simulation data. Performance analysis under different system configurations is conducted to demonstrate the feasibility and robustness of the proposed joint DSP algorithms.

Parametric analysis of diffuser requirements for high expansion ratio space engine

NASA Technical Reports Server (NTRS)

Wojciechowski, C. J.; Anderson, P. G.

1981-01-01

A supersonic diffuser ejector design computer program was developed. Using empirically modified one dimensional flow methods the diffuser ejector geometry is specified by the code. The design code results for calculations up to the end of the diffuser second throat were verified. Diffuser requirements for sea level testing of high expansion ratio space engines were defined. The feasibility of an ejector system using two commonly available turbojet engines feeding two variable area ratio ejectors was demonstrated.

High-precision arithmetic in mathematical physics

DOE PAGES

Bailey, David H.; Borwein, Jonathan M.

2015-05-12

For many scientific calculations, particularly those involving empirical data, IEEE 32-bit floating-point arithmetic produces results of sufficient accuracy, while for other applications IEEE 64-bit floating-point is more appropriate. But for some very demanding applications, even higher levels of precision are often required. Furthermore, this article discusses the challenge of high-precision computation, in the context of mathematical physics, and highlights what facilities are required to support future computation, in light of emerging developments in computer architecture.

System-Level Integration of Mass Memory

NASA Technical Reports Server (NTRS)

Cox, Brian; Mellstrom, Jeffrey; Wysocky, Terry

2008-01-01

A report discusses integrating multiple memory modules on the high-speed serial interconnect (IEEE 1393) that is used by a spacecraft?s inter-module communications in order to ease data congestion and provide for a scalable, strong, flexible system that can meet new system-level mass memory requirements.

Temporal analysis of the frequency and duration of low and high streamflow: Years of record needed to characterize streamflow variability

USGS Publications Warehouse

Huh, S.; Dickey, D.A.; Meador, M.R.; Ruhl, K.E.

2005-01-01

A temporal analysis of the number and duration of exceedences of high- and low-flow thresholds was conducted to determine the number of years required to detect a level shift using data from Virginia, North Carolina, and South Carolina. Two methods were used - ordinary least squares assuming a known error variance and generalized least squares without a known error variance. Using ordinary least squares, the mean number of years required to detect a one standard deviation level shift in measures of low-flow variability was 57.2 (28.6 on either side of the break), compared to 40.0 years for measures of high-flow variability. These means become 57.6 and 41.6 when generalized least squares is used. No significant relations between years and elevation or drainage area were detected (P>0.05). Cluster analysis did not suggest geographic patterns in years related to physiography or major hydrologic regions. Referring to the number of observations required to detect a one standard deviation shift as 'characterizing' the variability, it appears that at least 20 years of record on either side of a shift may be necessary to adequately characterize high-flow variability. A longer streamflow record (about 30 years on either side) may be required to characterize low-flow variability. ?? 2005 Elsevier B.V. All rights reserved.

Do you have what it takes for challenging endoscopic submucosal dissection cases?

PubMed Central

Kim, Kyoung-Oh; Kim, Sung Jung; Kim, Tae Hyeon; Park, Jong-Jae

2011-01-01

Endoscopic submucosal dissection (ESD) is a widely accepted treatment for early gastric cancer (EGC), especially in Korea and Japan. The criteria for the therapeutic use of ESD for EGC have been expanded recently. However, attention should be drawn to the technical feasibility of the ESD treatment which depends on a lesion’s location, size or fibrosis level, or operator’s experience. In the case of a lesion with a high level of difficulty, a more experienced operator is required. Thus, the treatment for a lesion with a high level of difficulty should be performed according to the degree of the operator’s experience. In this paper, the authors describe the ESD procedure for lesions with a high level of difficulty. PMID:21987603

The Hyperflexible Hip

PubMed Central

Weber, Alexander E.; Bedi, Asheesh; Tibor, Lisa M.; Zaltz, Ira; Larson, Christopher M.

2015-01-01

Context: Dance, gymnastics, figure skating, and competitive cheerleading require a high degree of hip range of motion. Athletes who participate in these sports use their hips in a mechanically complex manner. Evidence Acquisition: A search of the entire PubMed database (through December 2013) and additional searches of the reference lists of pertinent articles. Study Design: Systematic review. Level of Evidence: Level 3. Results: Whether innate or acquired, dancers and gymnasts have some hypermobility that allows their hips to be placed in potentially impinging or unstable positions required for their given activity. Such extremes of motion can result in both intra-articular and extra-articular impingement as well as compensatory osseous and muscular pathology. In addition, dancers and gymnasts are susceptible to impingement-induced instability. Dancers with innate generalized hyperlaxity are at increased risk of injury because of their activities and may require longer recovery times to return to play. Both nonoperative and operative treatments (arthroscopic and open) have an important role in returning flexibility athletes to their preoperative levels of sport and dance. Conclusion: Because of the extreme hip motion required and the compensatory soft tissue laxity in dancers and gymnasts, these athletes may develop instability, impingement, or combinations of both. This frequently occurs in the setting of subtle pathoanatomy or in patients with normal bony anatomy. With appropriate surgical indications and the correct operative technique, the treating surgeon can anticipate high levels of return to play for the gymnast and dancer with hip pain. PMID:26137181

Are all types of expertise created equal? Car experts use different spatial frequency scales for subordinate categorization of cars and faces.

PubMed

Harel, Assaf; Bentin, Shlomo

2013-01-01

A much-debated question in object recognition is whether expertise for faces and expertise for non-face objects utilize common perceptual information. We investigated this issue by assessing the diagnostic information required for different types of expertise. Specifically, we asked whether face categorization and expert car categorization at the subordinate level relies on the same spatial frequency (SF) scales. Fifteen car experts and fifteen novices performed a category verification task with spatially filtered images of faces, cars, and airplanes. Images were categorized based on their basic (e.g. "car") and subordinate level (e.g. "Japanese car") identity. The effect of expertise was not evident when objects were categorized at the basic level. However, when the car experts categorized faces and cars at the subordinate level, the two types of expertise required different kinds of SF information. Subordinate categorization of faces relied on low SFs more than on high SFs, whereas subordinate expert car categorization relied on high SFs more than on low SFs. These findings suggest that expertise in the recognition of objects and faces do not utilize the same type of information. Rather, different types of expertise require different types of diagnostic visual information.

Are All Types of Expertise Created Equal? Car Experts Use Different Spatial Frequency Scales for Subordinate Categorization of Cars and Faces

PubMed Central

Harel, Assaf; Bentin, Shlomo

2013-01-01

A much-debated question in object recognition is whether expertise for faces and expertise for non-face objects utilize common perceptual information. We investigated this issue by assessing the diagnostic information required for different types of expertise. Specifically, we asked whether face categorization and expert car categorization at the subordinate level relies on the same spatial frequency (SF) scales. Fifteen car experts and fifteen novices performed a category verification task with spatially filtered images of faces, cars, and airplanes. Images were categorized based on their basic (e.g. “car”) and subordinate level (e.g. “Japanese car”) identity. The effect of expertise was not evident when objects were categorized at the basic level. However, when the car experts categorized faces and cars at the subordinate level, the two types of expertise required different kinds of SF information. Subordinate categorization of faces relied on low SFs more than on high SFs, whereas subordinate expert car categorization relied on high SFs more than on low SFs. These findings suggest that expertise in the recognition of objects and faces do not utilize the same type of information. Rather, different types of expertise require different types of diagnostic visual information. PMID:23826188

Sequence Requirements of the 5-Enolpyruvylshikimate-3-phosphate Synthase 5[prime]-Upstream Region for Tissue-Specific Expression in Flowers and Seedlings.

PubMed Central

Benfey, PN; Takatsuji, H; Ren, L; Shah, DM; Chua, NH

1990-01-01

We have analyzed expression from deletion derivatives of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) 5[prime]-upstream region in transgenic petunia flowers and seedlings. In seedlings, expression was strongest in root cortex cells and in trichomes. High-level expression in petals and in seedling roots was conferred by large (>500 base-pair) stretches of sequence, but was lost when smaller fragments were analyzed individually. This apparent requirement for extensive sequence suggests that combinations of cis-elements that are widely separated control tissue-specific expression from the EPSPS promoter. We have also used the high-level, petal-specific expression of the EPSPS promoter to change petal color in two mutant petunia lines. PMID:12354968

The GATE Way to Equity.

ERIC Educational Resources Information Center

Belz, Helene F.

Systematic observations of thousands of high school students in the California Mentally Gifted Minors/Gifted and Talented Education programs identified five principles underlying the development of high level thinking skills in this population: (1) Exceptional performance on any criterion requires mutually reinforcing antecedents, the effects of…

29 CFR 778.603 - Special overtime provisions for certain employees receiving remedial education under section 7(q).

Code of Federal Regulations, 2011 CFR

2011-07-01

... provided that the employee lacks a high school diploma or educational attainment at the eighth-grade level... or below, or to fulfill the requirements for a high school diploma or General Educational Development...

Acoustic characterization of a nonlinear vibroacoustic absorber at low frequencies and high sound levels

NASA Astrophysics Data System (ADS)

Chauvin, A.; Monteil, M.; Bellizzi, S.; Côte, R.; Herzog, Ph.; Pachebat, M.

2018-03-01

A nonlinear vibroacoustic absorber (Nonlinear Energy Sink: NES), involving a clamped thin membrane made in Latex, is assessed in the acoustic domain. This NES is here considered as an one-port acoustic system, analyzed at low frequencies and for increasing excitation levels. This dynamic and frequency range requires a suitable experimental technique, which is presented first. It involves a specific impedance tube able to deal with samples of sufficient size, and reaching high sound levels with a guaranteed linear response thank's to a specific acoustic source. The identification method presented here requires a single pressure measurement, and is calibrated from a set of known acoustic loads. The NES reflection coefficient is then estimated at increasing source levels, showing its strong level dependency. This is presented as a mean to understand energy dissipation. The results of the experimental tests are first compared to a nonlinear viscoelastic model of the membrane absorber. In a second step, a family of one degree of freedom models, treated as equivalent Helmholtz resonators is identified from the measurements, allowing a parametric description of the NES behavior over a wide range of levels.

Spore Heat Activation Requirements and Germination Responses Correlate with Sequences of Germinant Receptors and with the Presence of a Specific spoVA2mob Operon in Foodborne Strains of Bacillus subtilis.

PubMed

Krawczyk, Antonina O; de Jong, Anne; Omony, Jimmy; Holsappel, Siger; Wells-Bennik, Marjon H J; Kuipers, Oscar P; Eijlander, Robyn T

2017-04-01

Spore heat resistance, germination, and outgrowth are problematic bacterial properties compromising food safety and quality. Large interstrain variation in these properties makes prediction and control of spore behavior challenging. High-level heat resistance and slow germination of spores of some natural Bacillus subtilis isolates, encountered in foods, have been attributed to the occurrence of the spoVA 2mob operon carried on the Tn 1546 transposon. In this study, we further investigate the correlation between the presence of this operon in high-level-heat-resistant spores and their germination efficiencies before and after exposure to various sublethal heat treatments (heat activation, or HA), which are known to significantly improve spore responses to nutrient germinants. We show that high-level-heat-resistant spores harboring spoVA 2mob required higher HA temperatures for efficient germination than spores lacking spoVA 2mob The optimal spore HA requirements additionally depended on the nutrients used to trigger germination, l-alanine (l-Ala), or a mixture of l-asparagine, d-glucose, d-fructose, and K + (AGFK). The distinct HA requirements of these two spore germination pathways are likely related to differences in properties of specific germinant receptors. Moreover, spores that germinated inefficiently in AGFK contained specific changes in sequences of the GerB and GerK germinant receptors, which are involved in this germination response. In contrast, no relation was found between transcription levels of main germination genes and spore germination phenotypes. The findings presented in this study have great implications for practices in the food industry, where heat treatments are commonly used to inactivate pathogenic and spoilage microbes, including bacterial spore formers. IMPORTANCE This study describes a strong variation in spore germination capacities and requirements for a heat activation treatment, i.e., an exposure to sublethal heat that increases spore responsiveness to nutrient germination triggers, among 17 strains of B. subtilis , including 9 isolates from spoiled food products. Spores of industrial foodborne isolates exhibited, on average, less efficient and slower germination responses and required more severe heat activation than spores from other sources. High heat activation requirements and inefficient, slow germination correlated with elevated resistance of spores to heat and with specific genetic features, indicating a common genetic basis of these three phenotypic traits. Clearly, interstrain variation and numerous factors that shape spore germination behavior challenge standardization of methods to recover highly heat-resistant spores from the environment and have an impact on the efficacy of preservation techniques used by the food industry to control spores. Copyright © 2017 American Society for Microbiology.

Spore Heat Activation Requirements and Germination Responses Correlate with Sequences of Germinant Receptors and with the Presence of a Specific spoVA2mob Operon in Foodborne Strains of Bacillus subtilis

PubMed Central

Krawczyk, Antonina O.; de Jong, Anne; Omony, Jimmy; Holsappel, Siger; Wells-Bennik, Marjon H. J.; Eijlander, Robyn T.

2017-01-01

ABSTRACT Spore heat resistance, germination, and outgrowth are problematic bacterial properties compromising food safety and quality. Large interstrain variation in these properties makes prediction and control of spore behavior challenging. High-level heat resistance and slow germination of spores of some natural Bacillus subtilis isolates, encountered in foods, have been attributed to the occurrence of the spoVA2mob operon carried on the Tn1546 transposon. In this study, we further investigate the correlation between the presence of this operon in high-level-heat-resistant spores and their germination efficiencies before and after exposure to various sublethal heat treatments (heat activation, or HA), which are known to significantly improve spore responses to nutrient germinants. We show that high-level-heat-resistant spores harboring spoVA2mob required higher HA temperatures for efficient germination than spores lacking spoVA2mob. The optimal spore HA requirements additionally depended on the nutrients used to trigger germination, l-alanine (l-Ala), or a mixture of l-asparagine, d-glucose, d-fructose, and K+ (AGFK). The distinct HA requirements of these two spore germination pathways are likely related to differences in properties of specific germinant receptors. Moreover, spores that germinated inefficiently in AGFK contained specific changes in sequences of the GerB and GerK germinant receptors, which are involved in this germination response. In contrast, no relation was found between transcription levels of main germination genes and spore germination phenotypes. The findings presented in this study have great implications for practices in the food industry, where heat treatments are commonly used to inactivate pathogenic and spoilage microbes, including bacterial spore formers. IMPORTANCE This study describes a strong variation in spore germination capacities and requirements for a heat activation treatment, i.e., an exposure to sublethal heat that increases spore responsiveness to nutrient germination triggers, among 17 strains of B. subtilis, including 9 isolates from spoiled food products. Spores of industrial foodborne isolates exhibited, on average, less efficient and slower germination responses and required more severe heat activation than spores from other sources. High heat activation requirements and inefficient, slow germination correlated with elevated resistance of spores to heat and with specific genetic features, indicating a common genetic basis of these three phenotypic traits. Clearly, interstrain variation and numerous factors that shape spore germination behavior challenge standardization of methods to recover highly heat-resistant spores from the environment and have an impact on the efficacy of preservation techniques used by the food industry to control spores. PMID:28130296

Parents' Perceptions of Teacher Support at a Cyber Charter High School

ERIC Educational Resources Information Center

Borup, Jered; Stevens, Mark A.

2016-01-01

Despite high growth rates, cyber charter schools experience higher attrition rates than their brick-and-mortar counterparts. Students' reasons for failing an online course are complex and students may require a high level of teacher support to be successful online. Research examining effective teacher engagement has relied heavily on teacher…

Raman spectroscopy for grading of live osteosarcoma cells.

PubMed

Chiang, Yi-Hung; Wu, Stewart H; Kuo, Yi-Chun; Chen, How-Foo; Chiou, Arthur; Lee, Oscar K

2015-04-18

Osteosarcoma is the most common primary malignant bone tumor, and the grading of osteosarcoma cells relies on traditional histopathology and molecular biology methods, which require RNA extraction, protein isolation and immunohistological staining. All these methods require cell isolation, lysis or fixation, which is time-consuming and requires certain amount of tumor specimen. In this study, we report the use of Raman spectroscopy for grading of malignant osteosarcoma cells. We demonstrate that, based on the detection of differential production of mineral species, Raman spectroscopy can be used as a live cell analyzer to accurately assess the grades of osteosarcoma cells by evaluating their mineralization levels. Mineralization level was assessed by measuring amount of hydroxyapatite (HA), which is highly expressed in mature osteoblasts, but not in poorly differentiated osteosarcoma cell or mesenchymal stem cells, the putative cell-of-origin of osteosarcoma. We found that under Raman spectroscopy, the level of HA production was high in MG-63 cells, which are low-grade. Moreover, hydroxyapatite production was low in high-grade osteosarcoma cells such as 143B and SaOS2 cells (p < 0.05). Matrix metalloproteinase MMP2, MMP9 were highly expressed in SaOS2, 143B and MSCs and decreased in human fetal osteoblast (FOB) and MG-63 cells as expected (p < 0.05). These results may highlight the inverse correlation between HA level and prognosis of osteosarcoma. The use of Raman spectroscopy for the measurement of HA production by the protocol reported in this study may serve as a useful tool to rapidly and accurately assess the degree of malignancy in osteosarcoma cells in a label-free manner. Such application may shorten the period of pathological diagnosis and may benefit patients who are inflicted with osteosarcoma.

Differential cellular responses by oncogenic levels of c-Myc expression in long-term confluent retinal pigment epithelial cells.

PubMed

Wang, Yiping; Cheng, Xiangdong; Samma, Muhammad Kaleem; Kung, Sam K P; Lee, Clement M; Chiu, Sung Kay

2018-06-01

c-Myc is a highly pleiotropic transcription factor known to control cell cycle progression, apoptosis, and cellular transformation. Normally, ectopic expression of c-Myc is associated with promoting cell proliferation or triggering cell death via activating p53. However, it is not clear how the levels of c-Myc lead to different cellular responses. Here, we generated a series of stable RPE cell clones expressing c-Myc at different levels, and found that consistent low level of c-Myc induced cellular senescence by activating AP4 in post-confluent RPE cells, while the cells underwent cell death at high level of c-Myc. In addition, high level of c-Myc could override the effect of AP4 on cellular senescence. Further knockdown of AP4 abrogated senescence-like phenotype in cells expressing low level of c-Myc, and accelerated cell death in cells with medium level of c-Myc, indicating that AP4 was required for cellular senescence induced by low level of c-Myc.

Assessment of Galileo modal test results for mathematical model verification

NASA Technical Reports Server (NTRS)

Trubert, M.

1984-01-01

The modal test program for the Galileo Spacecraft was completed at the Jet Propulsion Laboratory in the summer of 1983. The multiple sine dwell method was used for the baseline test. The Galileo Spacecraft is a rather complex 2433 kg structure made of a central core on which seven major appendages representing 30 percent of the total mass are attached, resulting in a high modal density structure. The test revealed a strong nonlinearity in several major modes. This nonlinearity discovered in the course of the test necessitated running additional tests at the unusually high response levels of up to about 21 g. The high levels of response were required to obtain a model verification valid at the level of loads for which the spacecraft was designed. Because of the high modal density and the nonlinearity, correlation between the dynamic mathematical model and the test results becomes a difficult task. Significant changes in the pre-test analytical model are necessary to establish confidence in the upgraded analytical model used for the final load verification. This verification, using a test verified model, is required by NASA to fly the Galileo Spacecraft on the Shuttle/Centaur launch vehicle in 1986.

Microstructured snow targets for high energy quasi-monoenergetic proton acceleration

NASA Astrophysics Data System (ADS)

Schleifer, E.; Nahum, E.; Eisenmann, S.; Botton, M.; Baspaly, A.; Pomerantz, I.; Abricht, F.; Branzel, J.; Priebe, G.; Steinke, S.; Andreev, A.; Schnuerer, M.; Sandner, W.; Gordon, D.; Sprangle, P.; Ledingham, K. W. D.; Zigler, A.

2013-05-01

Compact size sources of high energy protons (50-200MeV) are expected to be key technology in a wide range of scientific applications 1-8. One promising approach is the Target Normal Sheath Acceleration (TNSA) scheme 9,10, holding record level of 67MeV protons generated by a peta-Watt laser 11. In general, laser intensity exceeding 1018 W/cm2 is required to produce MeV level protons. Another approach is the Break-Out Afterburner (BOA) scheme which is a more efficient acceleration scheme but requires an extremely clean pulse with contrast ratio of above 10-10. Increasing the energy of the accelerated protons using modest energy laser sources is a very attractive task nowadays. Recently, nano-scale targets were used to accelerate ions 12,13 but no significant enhancement of the accelerated proton energy was measured. Here we report on the generation of up to 20MeV by a modest (5TW) laser system interacting with a microstructured snow target deposited on a Sapphire substrate. This scheme relax also the requirement of high contrast ratio between the pulse and the pre-pulse, where the latter produces the highly structured plasma essential for the interaction process. The plasma near the tip of the snow target is subject to locally enhanced laser intensity with high spatial gradients, and enhanced charge separation is obtained. Electrostatic fields of extremely high intensities are produced, and protons are accelerated to MeV-level energies. PIC simulations of this targets reproduce the experimentally measured energy scaling and predict the generation of 150 MeV protons from laser power of 100TW laser system18.

User interface support

NASA Technical Reports Server (NTRS)

Lewis, Clayton; Wilde, Nick

1989-01-01

Space construction will require heavy investment in the development of a wide variety of user interfaces for the computer-based tools that will be involved at every stage of construction operations. Using today's technology, user interface development is very expensive for two reasons: (1) specialized and scarce programming skills are required to implement the necessary graphical representations and complex control regimes for high-quality interfaces; (2) iteration on prototypes is required to meet user and task requirements, since these are difficult to anticipate with current (and foreseeable) design knowledge. We are attacking this problem by building a user interface development tool based on extensions to the spreadsheet model of computation. The tool provides high-level support for graphical user interfaces and permits dynamic modification of interfaces, without requiring conventional programming concepts and skills.

Fire safety

Treesearch

Robert H. White; Mark A. Dietenberger

1999-01-01

Fire safety is an important concern in all types of construction. The high level of national concern for fire safety is reflected in limitations and design requirements in building codes. These code requirements are discussed in the context of fire safety design and evaluation in the initial section of this chapter. Since basic data on fire behavior of wood products...

10 CFR 63.121 - Requirements for ownership and control of interests in land.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Requirements for ownership and control of interests in land. 63.121 Section 63.121 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL... repository operations area. DOE shall exercise any jurisdiction and control over surface and subsurface...

10 CFR 60.121 - Requirements for ownership and control of interests in land.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Requirements for ownership and control of interests in land. 60.121 Section 60.121 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL... postclosure controlled area. DOE shall exercise any jurisdiction and control over surface and subsurface...

Identifying Skill Requirements for GIS Positions: A Content Analysis of Job Advertisements

ERIC Educational Resources Information Center

Hong, Jung Eun

2016-01-01

This study identifies the skill requirements for geographic information system (GIS) positions, including GIS analysts, programmers/developers/engineers, specialists, and technicians, through a content analysis of 946 GIS job advertisements from 2007-2014. The results indicated that GIS job applicants need to possess high levels of GIS analysis…

Educational JavaBeans: a Requirements Driven Architecture.

ERIC Educational Resources Information Center

Hall, Jon; Rapanotti, Lucia

This paper investigates, through a case study, the development of a software architecture that is compatible with a system's high-level requirements. The case study is an example of an extended customer/supplier relationship (post-point of sale support) involved in e-universities and is representative of a class of enterprise without current…

Brain Stretchers, Book 1.

ERIC Educational Resources Information Center

Anderson, Carolyn; Haller, Jackie

This collection of activities is designed to help students develop critical thinking skills. The activities are non-graded and can be used from upper elementary to high school. Reading levels vary from no reading required to very little reading required and can be used effectively with students who are poor readers, bilingual, or at a special…

Brain Stretchers, Book 2.

ERIC Educational Resources Information Center

Anderson, Carolyn; Haller, Jackie

This collection of activities is designed to help students develop critical thinking skills. The activities are non-graded and can be used from upper elementary to high school. The reading levels vary from no reading required to very little reading required and can be used effectively with students who are poor readers, bilingual, or at a special…

40 CFR 142.62 - Variances and exemptions from the maximum contaminant levels for organic and inorganic chemicals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... be required to convert Arsenic III to Arsenic V. 5 To obtain high removals, iron to arsenic ratio... Exchange 6=Lime Softening (not BAT for systems Corrosion... corrosion control treatment requirements for lead and copper in §§ 141.81 and 141.82 to avoid an...

The Strategy Project: Promoting Self-Regulated Learning through an Authentic Assignment

ERIC Educational Resources Information Center

Steiner, Hillary H.

2016-01-01

Success in college requires the development of self-regulated learning strategies that move beyond high school skills. First-year students of all ability levels benefit when given instruction in how to use these strategies in an authentic context. This paper presents an instructional method that requires deliberate practice of self-regulated…

Perceived Challenges to Integrating Reading Strategies in Content Areas: A Single Case Study

ERIC Educational Resources Information Center

Pezzolla, Karen

2017-01-01

An alarming percentage of middle and high school students find themselves unable to read their textbooks at grade level proficiency; lacking the necessary skills to access and process information, and read critically. The Common Core State Standards require students to apply reading strategies across the curriculum, therefore requiring teachers to…

Physical and energy requirements of competitive swimming events.

PubMed

Pyne, David B; Sharp, Rick L

2014-08-01

The aquatic sports competitions held during the summer Olympic Games include diving, open-water swimming, pool swimming, synchronized swimming, and water polo. Elite-level performance in each of these sports requires rigorous training and practice to develop the appropriate physiological, biomechanical, artistic, and strategic capabilities specific to each sport. Consequently, the daily training plans of these athletes are quite varied both between and within the sports. Common to all aquatic athletes, however, is that daily training and preparation consumes several hours and involves frequent periods of high-intensity exertion. Nutritional support for this high-level training is a critical element of the preparation of these athletes to ensure the energy and nutrient demands of the training and competition are met. In this article, we introduce the fundamental physical requirements of these sports and specifically explore the energetics of human locomotion in water. Subsequent articles in this issue explore the specific nutritional requirements of each aquatic sport. We hope that such exploration will provide a foundation for future investigation of the roles of optimal nutrition in optimizing performance in the aquatic sports.

Structuring Formal Control Systems Specifications for Reuse: Surviving Hardware Changes

NASA Technical Reports Server (NTRS)

Thompson, Jeffrey M.; Heimdahl, Mats P. E.; Erickson, Debra M.

2000-01-01

Formal capture and analysis of the required behavior of control systems have many advantages. For instance, it encourages rigorous requirements analysis, the required behavior is unambiguously defined, and we can assure that various safety properties are satisfied. Formal modeling is, however, a costly and time consuming process and if one could reuse the formal models over a family of products, significant cost savings would be realized. In an ongoing project we are investigating how to structure state-based models to achieve a high level of reusability within product families. In this paper we discuss a high-level structure of requirements models that achieves reusability of the desired control behavior across varying hardware platforms in a product family. The structuring approach is demonstrated through a case study in the mobile robotics domain where the desired robot behavior is reused on two diverse platforms-one commercial mobile platform and one build in-house. We use our language RSML (-e) to capture the control behavior for reuse and our tool NIMBUS to demonstrate how the formal specification can be validated and used as a prototype on the two platforms.

Requirements Development for the NASA Advanced Engineering Environment (AEE)

NASA Technical Reports Server (NTRS)

Rogers, Eric; Hale, Joseph P.; Zook, Keith; Gowda, Sanjay; Salas, Andrea O.

2003-01-01

The requirements development process for the Advanced Engineering Environment (AEE) is presented. This environment has been developed to allow NASA to perform independent analysis and design of space transportation architectures and technologies. Given the highly collaborative and distributed nature of AEE, a variety of organizations are involved in the development, operations and management of the system. Furthermore, there are additional organizations involved representing external customers and stakeholders. Thorough coordination and effective communication is essential to translate desired expectations of the system into requirements. Functional, verifiable requirements for this (and indeed any) system are necessary to fulfill several roles. Requirements serve as a contractual tool, configuration management tool, and as an engineering tool, sometimes simultaneously. The role of requirements as an engineering tool is particularly important because a stable set of requirements for a system provides a common framework of system scope and characterization among team members. Furthermore, the requirements provide the basis for checking completion of system elements and form the basis for system verification. Requirements are at the core of systems engineering. The AEE Project has undertaken a thorough process to translate the desires and expectations of external customers and stakeholders into functional system-level requirements that are captured with sufficient rigor to allow development planning, resource allocation and system-level design, development, implementation and verification. These requirements are maintained in an integrated, relational database that provides traceability to governing Program requirements and also to verification methods and subsystem-level requirements.

49 CFR 38.95 - Mobility aid accessibility.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SPECIFICATIONS FOR TRANSPORTATION VEHICLES Commuter Rail Cars and Systems § 38.95 Mobility aid accessibility... rail cars, other than level entry cars, covered by this subpart shall provide a level-change mechanism... accessible, or mini-high platforms complying with § 38.93(d) are provided, the car is not required to be...

Software quality assurance | News

Science.gov Websites

Measure was removed: "Sufficient level of detail in the requirements to develop test cases." ; This control measure was removed since the sufficient level of detail needed to develop test cases is recorded for all test cases. (Note: This is mandatory for applications graded with a High Quality Assurance

An example of requirements for Advanced Subsonic Civil Transport (ASCT) flight control system using structured techniques

NASA Technical Reports Server (NTRS)

Mclees, Robert E.; Cohen, Gerald C.

1991-01-01

The requirements are presented for an Advanced Subsonic Civil Transport (ASCT) flight control system generated using structured techniques. The requirements definition starts from initially performing a mission analysis to identify the high level control system requirements and functions necessary to satisfy the mission flight. The result of the study is an example set of control system requirements partially represented using a derivative of Yourdon's structured techniques. Also provided is a research focus for studying structured design methodologies and in particular design-for-validation philosophies.

High-power lasers for directed-energy applications.

PubMed

Sprangle, Phillip; Hafizi, Bahman; Ting, Antonio; Fischer, Richard

2015-11-01

In this article, we review and discuss the research programs at the Naval Research Laboratory (NRL) on high-power lasers for directed-energy (DE) applications in the atmosphere. Physical processes affecting propagation include absorption/scattering, turbulence, and thermal blooming. The power levels needed for DE applications require combining a number of lasers. In atmospheric turbulence, there is a maximum intensity that can be placed on a target that is independent of the initial beam spot size and laser beam quality. By combining a number of kW-class fiber lasers, scientists at the NRL have successfully demonstrated high-power laser propagation in a turbulent atmosphere and wireless recharging. In the NRL experiments, four incoherently combined fiber lasers having a total power of 5 kW were propagated to a target 3.2 km away. These successful high-power experiments in a realistic atmosphere formed the basis of the Navy's Laser Weapon System. We compare the propagation characteristics of coherently and incoherently combined beams without adaptive optics. There is little difference in the energy on target between coherently and incoherently combined laser beams for multi-km propagation ranges and moderate to high levels of turbulence. Unlike incoherent combining, coherent combining places severe constraints on the individual lasers. These include the requirement of narrow power spectral linewidths in order to have long coherence times as well as polarization alignment of all the lasers. These requirements are extremely difficult for high-power lasers.

Finding the bottom and using it

PubMed Central

Sandoval, Ruben M.; Wang, Exing; Molitoris, Bruce A.

2014-01-01

Maximizing 2-photon parameters used in acquiring images for quantitative intravital microscopy, especially when high sensitivity is required, remains an open area of investigation. Here we present data on correctly setting the black level of the photomultiplier tube amplifier by adjusting the offset to allow for accurate quantitation of low intensity processes. When the black level is set too high some low intensity pixel values become zero and a nonlinear degradation in sensitivity occurs rendering otherwise quantifiable low intensity values virtually undetectable. Initial studies using a series of increasing offsets for a sequence of concentrations of fluorescent albumin in vitro revealed a loss of sensitivity for higher offsets at lower albumin concentrations. A similar decrease in sensitivity, and therefore the ability to correctly determine the glomerular permeability coefficient of albumin, occurred in vivo at higher offset. Finding the offset that yields accurate and linear data are essential for quantitative analysis when high sensitivity is required. PMID:25313346

DRS: Derivational Reasoning System

NASA Technical Reports Server (NTRS)

Bose, Bhaskar

1995-01-01

The high reliability requirements for airborne systems requires fault-tolerant architectures to address failures in the presence of physical faults, and the elimination of design flaws during the specification and validation phase of the design cycle. Although much progress has been made in developing methods to address physical faults, design flaws remain a serious problem. Formal methods provides a mathematical basis for removing design flaws from digital systems. DRS (Derivational Reasoning System) is a formal design tool based on advanced research in mathematical modeling and formal synthesis. The system implements a basic design algebra for synthesizing digital circuit descriptions from high level functional specifications. DRS incorporates an executable specification language, a set of correctness preserving transformations, verification interface, and a logic synthesis interface, making it a powerful tool for realizing hardware from abstract specifications. DRS integrates recent advances in transformational reasoning, automated theorem proving and high-level CAD synthesis systems in order to provide enhanced reliability in designs with reduced time and cost.

Human-Robot Interaction in High Vulnerability Domains

NASA Technical Reports Server (NTRS)

Gore, Brian F.

2016-01-01

Future NASA missions will require successful integration of the human with highly complex systems. Highly complex systems are likely to involve humans, automation, and some level of robotic assistance. The complex environments will require successful integration of the human with automation, with robots, and with human-automation-robot teams to accomplish mission critical goals. Many challenges exist for the human performing in these types of operational environments with these kinds of systems. Systems must be designed to optimally integrate various levels of inputs and outputs based on the roles and responsibilities of the human, the automation, and the robots; from direct manual control, shared human-robotic control, or no active human control (i.e. human supervisory control). It is assumed that the human will remain involved at some level. Technologies that vary based on contextual demands and on operator characteristics (workload, situation awareness) will be needed when the human integrates into these systems. Predictive models that estimate the impact of the technologies on the system performance and the on the human operator are also needed to meet the challenges associated with such future complex human-automation-robot systems in extreme environments.

Activity-dependent regulation of NMDAR1 immunoreactivity in the developing visual cortex.

PubMed

Catalano, S M; Chang, C K; Shatz, C J

1997-11-01

NMDA receptors have been implicated in activity-dependent synaptic plasticity in the developing visual cortex. We examined the distribution of immunocytochemically detectable NMDAR1 in visual cortex of cats and ferrets from late embryonic ages to adulthood. Cortical neurons are initially highly immunostained. This level declines gradually over development, with the notable exception of cortical layers 2/3, where levels of NMDAR1 immunostaining remain high into adulthood. Within layer 4, the decline in NMDAR1 immunostaining to adult levels coincides with the completion of ocular dominance column formation and the end of the critical period for layer 4. To determine whether NMDAR1 immunoreactivity is regulated by retinal activity, animals were dark-reared or retinal activity was completely blocked in one eye with tetrodotoxin (TTX). Dark-rearing does not cause detectable changes in NMDAR1 immunoreactivity. However, 2 weeks of monocular TTX administration decreases NMDAR1 immunoreactivity in layer 4 of the columns of the blocked eye. Thus, high levels of NMDAR1 immunostaining within the visual cortex are temporally correlated with ocular dominance column formation and developmental plasticity; the persistence of staining in layers 2/3 also correlates with the physiological plasticity present in these layers in the adult. In addition, visual experience is not required for the developmental changes in the laminar pattern of NMDAR1 levels, but the presence of high levels of NMDAR1 in layer 4 during the critical period does require retinal activity. These observations are consistent with a central role for NMDA receptors in promoting and ultimately limiting synaptic rearrangements in the developing neocortex.

Bio-inspired approach for intelligent unattended ground sensors

NASA Astrophysics Data System (ADS)

Hueber, Nicolas; Raymond, Pierre; Hennequin, Christophe; Pichler, Alexander; Perrot, Maxime; Voisin, Philippe; Moeglin, Jean-Pierre

2015-05-01

Improving the surveillance capacity over wide zones requires a set of smart battery-powered Unattended Ground Sensors capable of issuing an alarm to a decision-making center. Only high-level information has to be sent when a relevant suspicious situation occurs. In this paper we propose an innovative bio-inspired approach that mimics the human bi-modal vision mechanism and the parallel processing ability of the human brain. The designed prototype exploits two levels of analysis: a low-level panoramic motion analysis, the peripheral vision, and a high-level event-focused analysis, the foveal vision. By tracking moving objects and fusing multiple criteria (size, speed, trajectory, etc.), the peripheral vision module acts as a fast relevant event detector. The foveal vision module focuses on the detected events to extract more detailed features (texture, color, shape, etc.) in order to improve the recognition efficiency. The implemented recognition core is able to acquire human knowledge and to classify in real-time a huge amount of heterogeneous data thanks to its natively parallel hardware structure. This UGS prototype validates our system approach under laboratory tests. The peripheral analysis module demonstrates a low false alarm rate whereas the foveal vision correctly focuses on the detected events. A parallel FPGA implementation of the recognition core succeeds in fulfilling the embedded application requirements. These results are paving the way of future reconfigurable virtual field agents. By locally processing the data and sending only high-level information, their energy requirements and electromagnetic signature are optimized. Moreover, the embedded Artificial Intelligence core enables these bio-inspired systems to recognize and learn new significant events. By duplicating human expertise in potentially hazardous places, our miniature visual event detector will allow early warning and contribute to better human decision making.

Changes in the faecal bile acid profile in dogs fed dry food vs high content of beef: a pilot study.

PubMed

Herstad, Kristin Marie Valand; Rønning, Helene Thorsen; Bakke, Anne Marie; Moe, Lars; Skancke, Ellen

2018-05-11

Dogs are fed various diets, which also include components of animal origin. In humans, a high-fat/low-fibre diet is associated with higher faecal levels of bile acids, which can influence intestinal health. It is unknown how an animal-based diet high in fat and low in fibre influences the faecal bile acid levels and intestinal health in dogs. This study investigated the effects of high intake of minced beef on the faecal bile acid profile in healthy, adult, client-owned dogs (n = 8) in a 7-week trial. Dogs were initially adapted to the same commercial dry food. Thereafter, incremental substitution of the dry food by boiled minced beef over 3 weeks resulted in a diet in which 75% of each dog's total energy requirement was provided as minced beef during week 5. Dogs were subsequently reintroduced to the dry food for the last 2 weeks of the study. The total taurine and glycine-conjugated bile acids, the primary bile acids chenodeoxycholic acid and cholic acid, and the secondary bile acids lithocholic acid, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) were analysed, using liquid chromatography-tandem mass spectrometry. The faecal quantities of DCA were significantly higher in dogs fed the high minced beef diet. These levels reversed when dogs were reintroduced to the dry food diet. The faecal levels of UDCA and taurine-conjugated bile acids had also increased in response to the beef diet, but this was only significant when compared to the last dry food period. These results suggest that an animal-based diet with high-fat/low-fibre content can influence the faecal bile acids levels. The consequences of this for canine colonic health will require further investigation.

Human salivary glucose analysis by high-performance ion-exchange chromatography and pulsed amperometric detection.

PubMed

Gough, H; Luke, G A; Beeley, J A; Geddes, D A

1996-02-01

The aim of this project was to develop an analytical procedure with the required level of sensitivity for the determination of glucose concentrations in small volumes of unstimulated fasting whole saliva. The technique involves high-performance ion-exchange chromatography at high pH and pulsed amperometric detection. It has a high level of reproducibility, a sensitivity as low as 0.1 mumol/l and requires only 50 microliters samples (sensitivity = 0.002 pmol). Inhibition of glucose metabolism, by procedures such as collection into 0.1% (w/v) sodium fluoride, was shown to be essential if accurate results are to be obtained. Collection on to ice followed by storage at -20 degrees C was shown to be unsuitable and resulted in glucose loss by degradation. There were inter- and intraindividual variations in the glucose concentration in unstimulated mixed saliva (range; 0.02-0.4 mmol/l). The procedure can be used for the analysis of other salivary carbohydrates and for monitoring the clearance of dietary carbohydrates from the mouth.

Recent experience with design and manufacture of cine lenses

NASA Astrophysics Data System (ADS)

Thorpe, Michael D.; Dalzell, Kristen E.

2015-09-01

Modern cine lenses require a high degree of aberration correction over a large and ever expanding image size. At low to medium volume production levels, these highly corrected designs also require a workable tolerance set and compensation scheme for successful manufacture. In this paper we discuss the design and manufacture of cine lenses with reference to current designs both internal and in the patent literature and some experience in design, tolerancing and manufacturing these lenses in medium volume production.

Advanced Materials and Component Development for Lithium-Ion Cells for NASA Missions

NASA Technical Reports Server (NTRS)

Reid, Concha M.

2012-01-01

Human missions to Near Earth Objects, such as asteroids, planets, moons, liberation points, and orbiting structures, will require safe, high specific energy, high energy density batteries to provide new or extended capabilities than are possible with today s state-of-the-art aerospace batteries. The Enabling Technology Development and Demonstration Program, High Efficiency Space Power Systems Project battery development effort at the National Aeronautics and Space Administration (NASA) is continuing advanced lithium-ion cell development efforts begun under the Exploration Technology Development Program Energy Storage Project. Advanced, high-performing materials are required to provide improved performance at the component-level that contributes to performance at the integrated cell level in order to meet the performance goals for NASA s High Energy and Ultra High Energy cells. NASA s overall approach to advanced cell development and interim progress on materials performance for the High Energy and Ultra High Energy cells after approximately 1 year of development has been summarized in a previous paper. This paper will provide an update on these materials through the completion of 2 years of development. The progress of materials development, remaining challenges, and an outlook for the future of these materials in near term cell products will be discussed.

High-dose anti-histamine use and risk factors in children with urticaria

PubMed Central

Uysal, Pınar; Avcil, Sibelnur; Erge, Duygu

2016-01-01

Aim The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria. Material and Methods The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria. Results The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p<0.0001). There was no difference between the two groups in terms of blood eosinophil and basophil counts, and serum total IgE levels (p>0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=−0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged ≥10 years (p<0.001, p=0.015). High UAS7 score (OR: 1.09; CI 95%: [1.03–1.15]) and basopenia (OR: 6.77; CI 95%: [2.01–22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria. Conclusion The requirement of high-dose H1-antihistamines was higher with children’s increasing age. Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines. PMID:28123332

Measuring Workload Differences Between Short-term Memory and Long-term Memory Scenarios in a Simulated Flight Environment

NASA Technical Reports Server (NTRS)

Berg, S. L.; Sheridan, T. B.

1984-01-01

Four highly experienced Air Force pilots each flew four simulated flight scenarios. Two scenarios required a great deal of aircraft maneuvering. The other two scenarios involved less maneuvering, but required remembering a number of items. All scenarios were designed to be equaly challenging. Pilot's Subjective Ratings for Activity-level, Complexity, Difficulty, Stress, and Workload were higher for the manuevering scenarios than the memory scenarios. At a moderate workload level, keeping the pilots active resulted in better aircraft control. When required to monitor and remember items, aircraft control tended to decrease. Pilots tended to weigh information about the spatial positioning and performance of their aircraft more heavily than other items.

Study, optimization, and design of a laser heat engine

NASA Technical Reports Server (NTRS)

1978-01-01

Laser heat engine concepts, proposed for satellite applications, were analyzed to determine which engine concepts best meet the requirements of high efficiency (50 percent or better) continuous operation in space. The best laser heat engine for a near-term experimental demonstration, selected on the basis of high overall operating efficiency, high power-to-weight characteristics, and availability of the required technology, is an Otto/Diesel cycle piston engine using a diamond window to admit CO2 laser radiation. The technology with the greatest promise of scaling to megawatt power levels in the long term is the energy exchanger/gas turbine combination.

The Time Required for Dormancy Release in Arabidopsis Is Determined by DELAY OF GERMINATION1 Protein Levels in Freshly Harvested Seeds[OA

PubMed Central

Nakabayashi, Kazumi; Bartsch, Melanie; Xiang, Yong; Miatton, Emma; Pellengahr, Silke; Yano, Ryoichi; Seo, Mitsunori; Soppe, Wim J.J.

2012-01-01

Seed dormancy controls the start of a plant’s life cycle by preventing germination of a viable seed in an unfavorable season. Freshly harvested seeds usually show a high level of dormancy, which is gradually released during dry storage (after-ripening). Abscisic acid (ABA) has been identified as an essential factor for the induction of dormancy, whereas gibberellins (GAs) are required for germination. The molecular mechanisms controlling seed dormancy are not well understood. DELAY OF GERMINATION1 (DOG1) was recently identified as a major regulator of dormancy in Arabidopsis thaliana. Here, we show that the DOG1 protein accumulates during seed maturation and remains stable throughout seed storage and imbibition. The levels of DOG1 protein in freshly harvested seeds highly correlate with dormancy. The DOG1 protein becomes modified during after-ripening, and its levels in stored seeds do not correlate with germination potential. Although ABA levels in dog1 mutants are reduced and GA levels enhanced, we show that DOG1 does not regulate dormancy primarily via changes in hormone levels. We propose that DOG1 protein abundance in freshly harvested seeds acts as a timer for seed dormancy release, which functions largely independent from ABA. PMID:22829147

Practical considerations in the development of hemoglobin-based oxygen therapeutics.

PubMed

Kim, Hae Won; Estep, Timothy N

2012-09-01

The development of hemoglobin based oxygen therapeutics (HBOCs) requires consideration of a number of factors. While the enabling technology derives from fundamental research on protein biochemistry and biological interactions, translation of these research insights into usable medical therapeutics demands the application of considerable technical expertise and consideration and reconciliation of a myriad of manufacturing, medical, and regulatory requirements. The HBOC development challenge is further exacerbated by the extremely high intravenous doses required for many of the indications contemplated for these products, which in turn implies an extremely high level of purity is required. This communication discusses several of the important product configuration and developmental considerations that impact the translation of fundamental research discoveries on HBOCs into usable medical therapeutics.

Can ivermectin mass treatments eliminate onchocerciasis in Africa?

PubMed Central

Winnen, M.; Plaisier, A. P.; Alley, E. S.; Nagelkerke, N. J. D.; van Oortmarssen, G.; Boatin, B. A.; Habbema, J. D. F.

2002-01-01

OBJECTIVE: To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community. METHODS: ONCHOSIM, a microsimulation model for onchocerciasis transmission, was used to explore the implications of different treatment intervals, coverage levels and precontrol endemicities for the likelihood of elimination. FINDINGS: Simulations suggested that control strategies based exclusively on ivermectin mass treatments could eliminate onchocerciasis. The duration of treatment required to eliminate infection depended heavily on the treatment programme and precontrol endemicity. In areas with medium to high levels of infection, annual mass treatments with 65% coverage for at least 25 years were necessary. Model predictions suggested that durations exceeding 35 years would be required if there were much heterogeneity in exposure to vector bites and, consequently, wide individual variation in microfilaria counts. If the treatment interval were reduced from 12 to 6 months the time for completion of the programme could be more than halved and elimination could be accomplished in areas of hyperendemicity, provided that the effects of each treatment would be the same as with annual treatments. However, it was doubtful whether high coverage levels could be sustained long enough to achieve worldwide eradication. CONCLUSION: Elimination of onchocerciasis from most endemic foci in Africa appears to be possible. However, the requirements in terms of duration, coverage, and frequency of treatment may be prohibitive in highly endemic areas. PMID:12077614

Uprated fine guidance sensor study

NASA Technical Reports Server (NTRS)

1984-01-01

Future orbital observatories will require star trackers of extremely high precision. These sensors must maintain high pointing accuracy and pointing stability simultaneously with a low light level signal from a guide star. To establish the fine guidance sensing requirements and to evaluate candidate fine guidance sensing concepts, the Space Telescope Optical Telescope Assembly was used as the reference optical system. The requirements review was separated into three areas: Optical Telescope Assembly (OTA), Fine Guidance Sensing and astrometry. The results show that the detectors should be installed directly onto the focal surface presented by the optics. This would maximize throughput and minimize point stability error by not incoporating any additional optical elements.

Parcel-scale urban coastal flood mapping: Leveraging the multi-scale CoSMoS model for coastal flood forecasting

NASA Astrophysics Data System (ADS)

Gallien, T.; Barnard, P. L.; Sanders, B. F.

2011-12-01

California coastal sea levels are projected to rise 1-1.4 meters in the next century and evidence suggests mean tidal range, and consequently, mean high water (MHW) is increasing along portions of Southern California Bight. Furthermore, emerging research indicates wind stress patterns associated with the Pacific Decadal Oscillation (PDO) have suppressed sea level rise rates along the West Coast since 1980, and a reversal in this pattern would result in the resumption of regional sea level rise rates equivalent to or exceeding global mean sea level rise rates, thereby enhancing coastal flooding. Newport Beach is a highly developed, densely populated lowland along the Southern California coast currently subject to episodic flooding from coincident high tides and waves, and the frequency and intensity of flooding is expected to increase with projected future sea levels. Adaptation to elevated sea levels will require flood mapping and forecasting tools that are sensitive to the dominant factors affecting flooding including extreme high tides, waves and flood control infrastructure. Considerable effort has been focused on the development of nowcast and forecast systems including Scripps Institute of Oceanography's Coastal Data Information Program (CDIP) and the USGS Multi-hazard model, the Southern California Coastal Storm Modeling System (CoSMoS). However, fine scale local embayment dynamics and overtopping flows are needed to map unsteady flooding effects in coastal lowlands protected by dunes, levees and seawalls. Here, a recently developed two dimensional Godunov non-linear shallow water solver is coupled to water level and wave forecasts from the CoSMoS model to investigate the roles of tides, waves, sea level changes and flood control infrastructure in accurate flood mapping and forecasting. The results of this study highlight the important roles of topographic data, embayment hydrodynamics, water level uncertainties and critical flood processes required for meaningful prediction of sea level rise impacts and coastal flood forecasting.

The art and science of missile defense sensor design

NASA Astrophysics Data System (ADS)

McComas, Brian K.

2014-06-01

A Missile Defense Sensor is a complex optical system, which sits idle for long periods of time, must work with little or no on-­board calibration, be used to find and discriminate targets, and guide the kinetic warhead to the target within minutes of launch. A short overview of the Missile Defense problem will be discussed here, as well as, the top-level performance drivers, like Noise Equivalent Irradiance (NEI), Acquisition Range, and Dynamic Range. These top-level parameters influence the choice of optical system, mechanical system, focal plane array (FPA), Read Out Integrated Circuit (ROIC), and cryogenic system. This paper will not only discuss the physics behind the performance of the sensor, but it will also discuss the "art" of optimizing the performance of the sensor given the top level performance parameters. Balancing the sensor sub-­systems is key to the sensor's performance in these highly stressful missions. Top-­level performance requirements impact the choice of lower level hardware and requirements. The flow down of requirements to the lower level hardware will be discussed. This flow down directly impacts the FPA, where careful selection of the detector is required. The flow down also influences the ROIC and cooling requirements. The key physics behind the detector and cryogenic system interactions will be discussed, along with the balancing of subsystem performance. Finally, the overall system balance and optimization will be discussed in the context of missile defense sensors and expected performance of the overall kinetic warhead.

Hemothorax with a high carbohydrate antigen 19-9 level caused by a bronchogenic cyst.

PubMed

Tsuzuku, Akifumi; Asano, Fumihiro; Murakami, Anri; Masuda, Atsunori; Sobajima, Takuya; Matsuno, Yoshihiko; Matsumoto, Shinsuke; Mori, Yoshio; Takiya, Hiroshi; Iwata, Hitoshi

2014-01-01

A 58-year-old man presented with right-sided chest pain. Radiography and computed tomography showed a pleural effusion in the right chest and a mass in the right hilum. Thoracentesis showed a hemothorax. The carbohydrate antigen (CA) 19-9 level in the pleural effusion was very high, requiring differentiation from malignancy. Positron emission tomography showed no significant fluorodeoxy glucose (FDG) accumulation. Magnetic resonance imaging revealed a cystic lesion. The tumor was resected for both a diagnosis and treatment. A pathological examination demonstrated a bronchogenic cyst. An immunohistochemical study suggested that the cyst was the source of the hemothorax and the high CA19-9 level.

[Pyroglutamic acidemia associated with acetaminophen].

PubMed

Alados Arboledas, F J; de la Oliva Senovilla, P; García Muñoz, Ma J; Alonso Melgar, A; Ruza Tarrío, F

2007-12-01

We report a case of pyroglutamic acidemia probably related to acetaminophen administration. A 16-month boy recovering from hemolytic uremic syndrome abruptly developed unexplained high anion gap metabolic acidosis requiring hemodialysis. Septic shock, lactic acidosis and salicylate intoxication were ruled out. Betahydroxybutyrate and acetoacetate levels were within the normal range. No osmolarity gap or high amino acid levels were found. Urine and blood pyroglutamic acid levels were 392 mmol/mol creatinine (reference range: 9-55) and 9.8 mmol/L (reference range<0.16), respectively. The patient was receiving acetaminophen. We conclude that pyroglutamic acidosis should be considered in patients receiving acetaminophen who abruptly develop high anion gap metabolic acidosis not attributable to more common causes.

Specification and Design Methodologies for High-Speed Fault-Tolerant Array Algorithms and Structures for VLSI.

DTIC Science & Technology

1987-06-01

evaluation and chip layout planning for VLSI digital systems. A high-level applicative (functional) language, implemented at UCLA, allows combining of...operating system. 2.1 Introduction The complexity of VLSI requires the application of CAD tools at all levels of the design process. In order to be...effective, these tools must be adaptive to the specific design. In this project we studied a design method based on the use of applicative languages

[New approach for managing microbial risks in food].

PubMed

Augustin, Jean-Christophe

2015-01-01

The aim of the food legislation is to ensure the protection of human health. Traditionally, the food legislation requires food business operators to apply good hygiene practices and specific procedures to control foodborne pathogens. These regulations allowed reaching a high level of health protection. The improvement of the system will require risk-based approaches. Firstly, risk assessment should allow the identification of high-risk situations where resources should be allocated for a better targeting of risk management. Then, management measures should be adapted to the health objective. In this approach, the appropriate level of protection is converted intofood safety and performance objectives on the food chain, i.e., maximum microbial contamination to fulfil the acceptable risk level. When objectives are defined, the food business operators and competent authorities can identify control options to comply with the objectives and establish microbiological criteria to verify compliance with these objectives. This approach, described for approximately 10 years, operative thanks to the development of quantitative risk assessment techniques, is still difficult to use in practical terms since it requires a commitment of competent authorities to define the acceptable risk and needs also the implementation of sometimes complex risk models.

Synthesizing Certified Code

NASA Technical Reports Server (NTRS)

Whalen, Michael; Schumann, Johann; Fischer, Bernd

2002-01-01

Code certification is a lightweight approach to demonstrate software quality on a formal level. Its basic idea is to require producers to provide formal proofs that their code satisfies certain quality properties. These proofs serve as certificates which can be checked independently. Since code certification uses the same underlying technology as program verification, it also requires many detailed annotations (e.g., loop invariants) to make the proofs possible. However, manually adding theses annotations to the code is time-consuming and error-prone. We address this problem by combining code certification with automatic program synthesis. We propose an approach to generate simultaneously, from a high-level specification, code and all annotations required to certify generated code. Here, we describe a certification extension of AUTOBAYES, a synthesis tool which automatically generates complex data analysis programs from compact specifications. AUTOBAYES contains sufficient high-level domain knowledge to generate detailed annotations. This allows us to use a general-purpose verification condition generator to produce a set of proof obligations in first-order logic. The obligations are then discharged using the automated theorem E-SETHEO. We demonstrate our approach by certifying operator safety for a generated iterative data classification program without manual annotation of the code.

Final Report - Regulatory Considerations for Adaptive Systems

NASA Technical Reports Server (NTRS)

Wilkinson, Chris; Lynch, Jonathan; Bharadwaj, Raj

2013-01-01

This report documents the findings of a preliminary research study into new approaches to the software design assurance of adaptive systems. We suggest a methodology to overcome the software validation and verification difficulties posed by the underlying assumption of non-adaptive software in the requirementsbased- testing verification methods in RTCA/DO-178B and C. An analysis of the relevant RTCA/DO-178B and C objectives is presented showing the reasons for the difficulties that arise in showing satisfaction of the objectives and suggested additional means by which they could be satisfied. We suggest that the software design assurance problem for adaptive systems is principally one of developing correct and complete high level requirements and system level constraints that define the necessary system functional and safety properties to assure the safe use of adaptive systems. We show how analytical techniques such as model based design, mathematical modeling and formal or formal-like methods can be used to both validate the high level functional and safety requirements, establish necessary constraints and provide the verification evidence for the satisfaction of requirements and constraints that supplements conventional testing. Finally the report identifies the follow-on research topics needed to implement this methodology.

How effective is integrated vector management against malaria and lymphatic filariasis where the diseases are transmitted by the same vector?

PubMed

Stone, Christopher M; Lindsay, Steve W; Chitnis, Nakul

2014-12-01

The opportunity to integrate vector management across multiple vector-borne diseases is particularly plausible for malaria and lymphatic filariasis (LF) control where both diseases are transmitted by the same vector. To date most examples of integrated control targeting these diseases have been unanticipated consequences of malaria vector control, rather than planned strategies that aim to maximize the efficacy and take the complex ecological and biological interactions between the two diseases into account. We developed a general model of malaria and LF transmission and derived expressions for the basic reproductive number (R0) for each disease. Transmission of both diseases was most sensitive to vector mortality and biting rate. Simulating different levels of coverage of long lasting-insecticidal nets (LLINs) and larval control confirms the effectiveness of these interventions for the control of both diseases. When LF was maintained near the critical density of mosquitoes, minor levels of vector control (8% coverage of LLINs or treatment of 20% of larval sites) were sufficient to eliminate the disease. Malaria had a far greater R0 and required a 90% population coverage of LLINs in order to eliminate it. When the mosquito density was doubled, 36% and 58% coverage of LLINs and larval control, respectively, were required for LF elimination; and malaria elimination was possible with a combined coverage of 78% of LLINs and larval control. Despite the low level of vector control required to eliminate LF, simulations suggest that prevalence of LF will decrease at a slower rate than malaria, even at high levels of coverage. If representative of field situations, integrated management should take into account not only how malaria control can facilitate filariasis elimination, but strike a balance between the high levels of coverage of (multiple) interventions required for malaria with the long duration predicted to be required for filariasis elimination.

ATLID beam steering mechanism and derived new piezoelectric-based devices for optical applications

NASA Astrophysics Data System (ADS)

Bourgain, F.; Barillot, F.; Belly, C.; Claeyssen, F.

2015-09-01

In Space & Defence (as well as in many others fields), there is a trend for miniaturisation in active optics requiring new actuators. Applications also often require the ability to withstand high vibrations and shocks levels, as well as vacuum compatibility for space applications. A new generation of small and smart actuators such as piezoelectric (piezo) actuators, are resolving this trend, thanks to their capacity to offer high energy density and to support both extreme and various requirements. This paper first presents the BSM mechanism and its requirements, the technologies involved in the design and the validation campaign results. Secondly, a derived XY piezoelectric positioning stage based on the same APA® and associated Strain Gage sensing technology is presented with its associated performances. Finally, a new piezoelectric motor based on the APA® technology, which allows the combination of long stroke while maintaining high resolution positioning of optical elements, is presented with experimental performances.

Improved LED backlight with unique color and intensity control and NVIS capability

NASA Astrophysics Data System (ADS)

Herman, Robert; Zagar, Pete; Ulijasz, Ted; Hansen, Hans C.; Ellner, Fred

2006-05-01

Currently deployed conventional flat panel AMLCD displays employ fluorescent lamp backlights to achieve the required lighting levels for cockpits in high performance aircraft. Advances have been made in backlighting technology by replacing fluorescent lamps with high performance LEDs. However, these new LED-based backlights are lacking in control of color and luminance intensity especially when related to NVIS requirements in a cockpit. This paper describes a unique integration of LED, electronic, and optical components to meet the requirements of high performance aircraft over their extreme range of operating environments. The LED-based backlight utilizes state-of-art components to enable daylight, night, and NVIS requirements to be implemented in a simple cost-effective package. The performance results presented highlight the advantages of this new design when compared to currently available backlighting designs. Techniques as described in section 2 of this paper are covered under patent application to the US and International Patent Offices.

EmptyHeaded: A Relational Engine for Graph Processing

PubMed Central

Aberger, Christopher R.; Tu, Susan; Olukotun, Kunle; Ré, Christopher

2016-01-01

There are two types of high-performance graph processing engines: low- and high-level engines. Low-level engines (Galois, PowerGraph, Snap) provide optimized data structures and computation models but require users to write low-level imperative code, hence ensuring that efficiency is the burden of the user. In high-level engines, users write in query languages like datalog (SociaLite) or SQL (Grail). High-level engines are easier to use but are orders of magnitude slower than the low-level graph engines. We present EmptyHeaded, a high-level engine that supports a rich datalog-like query language and achieves performance comparable to that of low-level engines. At the core of EmptyHeaded’s design is a new class of join algorithms that satisfy strong theoretical guarantees but have thus far not achieved performance comparable to that of specialized graph processing engines. To achieve high performance, EmptyHeaded introduces a new join engine architecture, including a novel query optimizer and data layouts that leverage single-instruction multiple data (SIMD) parallelism. With this architecture, EmptyHeaded outperforms high-level approaches by up to three orders of magnitude on graph pattern queries, PageRank, and Single-Source Shortest Paths (SSSP) and is an order of magnitude faster than many low-level baselines. We validate that EmptyHeaded competes with the best-of-breed low-level engine (Galois), achieving comparable performance on PageRank and at most 3× worse performance on SSSP. PMID:28077912

A Framework for RFID Survivability Requirement Analysis and Specification

NASA Astrophysics Data System (ADS)

Zuo, Yanjun; Pimple, Malvika; Lande, Suhas

Many industries are becoming dependent on Radio Frequency Identification (RFID) technology for inventory management and asset tracking. The data collected about tagged objects though RFID is used in various high level business operations. The RFID system should hence be highly available, reliable, and dependable and secure. In addition, this system should be able to resist attacks and perform recovery in case of security incidents. Together these requirements give rise to the notion of a survivable RFID system. The main goal of this paper is to analyze and specify the requirements for an RFID system to become survivable. These requirements, if utilized, can assist the system in resisting against devastating attacks and recovering quickly from damages. This paper proposes the techniques and approaches for RFID survivability requirements analysis and specification. From the perspective of system acquisition and engineering, survivability requirement is the important first step in survivability specification, compliance formulation, and proof verification.

High pressure processing and its application to the challenge of virus-contaminated foods

USDA-ARS?s Scientific Manuscript database

High pressure processing (HPP) is an increasingly popular non-thermal food processing technology. Study of HPP’s potential to inactivate foodborne viruses has defined general pressure levels required to inactivate hepatitis A virus, norovirus surrogates, and human norovirus itself within foods such...

Completing Algebra II in High School: Does It Increase College Access and Success?

ERIC Educational Resources Information Center

Kim, Jeongeun; Kim, Jiyun; DesJardins, Stephen L.; McCall, Brian P.

2015-01-01

Noting the benefits of mathematics in students' future educational attainment and labor market success, there is considerable interest in high school requirements in terms of course-taking in mathematics at the national, state, and school district level. Previous research indicates that taking advanced math courses in high school leads to positive…

High School Physical Education Requirements and Youth Body Weight: New Evidence from the YRBS.

PubMed

Sabia, Joseph J; Nguyen, Thanh Tam; Rosenberg, Oren

2017-10-01

Previous research has found that high school physical education (PE) requirements are largely ineffective at reducing youth body weight. However, these studies were forced to rely on cross-state variation in PE requirements to identify their impacts, raising concerns that estimated policy effects may be confounded by state-level unobservables. Using data from the State and National Youth Risk Behavior Surveys and exploiting recent changes in state high school PE laws, we re-examine the effect of PE requirements on body weight. Our estimates show that a one-semester increase in PE requirements is associated with a 10 to 13% increase in minutes per week spent physically active in PE classes, but with no change in net vigorous exercise and little change in youth body weight. We conclude that substitution of in-school for outside-of-school physical activity and small resultant net energy expenditures can explain the absence of body weight effects. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Compatibility Grab Sampling and Analysis Plan for FY 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

SASAKI, L.M.

1999-12-29

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for grab samples obtained to address waste compatibility. It is written in accordance with requirements identified in Data Quality Objectives for Tank Farms Waste Compatibility Program (Mulkey et al. 1999) and Tank Farm Waste Transfer Compatibility Program (Fowler 1999). In addition to analyses to support Compatibility, the Waste Feed Delivery program has requested that tank samples obtained for Compatibility also be analyzed to confirm the high-level waste and/or low-activity waste envelope(s) for the tank waste (Baldwin 1999). The analytical requirements tomore » confirm waste envelopes are identified in Data Quality Objectives for TWRS Privatization Phase I: Confirm Tank T is an Appropriate Feed Source for Low-Activity Waste Feed Batch X (Nguyen 1999a) and Data Quality Objectives for RPP Privatization Phase I: Confirm Tank T is an Appropriate Feed Source for High-Level Waste Feed Batch X (Nguyen 1999b).« less

The Role of Independent V&V in Upstream Software Development Processes

NASA Technical Reports Server (NTRS)

Easterbrook, Steve

1996-01-01

This paper describes the role of Verification and Validation (V&V) during the requirements and high level design processes, and in particular the role of Independent V&V (IV&V). The job of IV&V during these phases is to ensure that the requirements are complete, consistent and valid, and to ensure that the high level design meets the requirements. This contrasts with the role of Quality Assurance (QA), which ensures that appropriate standards and process models are defined and applied. This paper describes the current state of practice for IV&V, concentrating on the process model used in NASA projects. We describe a case study, showing the processes by which problem reporting and tracking takes place, and how IV&V feeds into decision making by the development team. We then describe the problems faced in implementing IV&V. We conclude that despite a well defined process model, and tools to support it, IV&V is still beset by communication and coordination problems.

Hearing, deaf, and hard-of-hearing Israeli adolescents' evaluations of deaf men and deaf women's occupational competence.

PubMed

Weisel, Amatzia; Cinamon, Rachel Gali

2005-01-01

This study examined 74 deaf and hard-of-hearing (D/HH) and 91 hearing high school students regarding their own occupational aspirations and their evaluations of occupational competence (EOCs) for deaf adults. In the EOC, participants rated the suitability of 25 occupations (varying according to prestige and required level of communication) for deaf men and women. The results showed that occupations requiring intensive communication levels, regardless of their prestige, were evaluated as much less suitable for deaf individuals than were those requiring less communication. D/HH adolescents did not find highly prestigious occupations as suitable for deaf adults even when communication barriers were irrelevant. Both D/HH and hearing participants expressed biased evaluations of deaf women's competence, but no further evidence emerged for stereotypic attitudes. Higher educational aspirations among hearing adolescents, especially hearing males, correlated with a higher EOC of deaf adults. No such associations emerged for D/HH participants. No gender effects emerged. Implications of these outcomes for career development, especially for females, were discussed.

Possible Brain Mechanisms of Creativity.

PubMed

Heilman, Kenneth M

2016-06-01

Creativity is the new discovery, understanding, development and expression of orderly and meaningful relationships. Creativity has three major stages: preparation, the development (nature and nurture) of critical knowledge and skills; innovation, the development of a creative solution; and creative production. Successful preparation requires a basic level of general intelligence and domain specific knowledge and skills and highly creative people may have anatomic alterations of specific neocortical regions. Innovation requires disengagement and divergent thinking primarily mediated by frontal networks. Creative people are often risk-takers and novelty seekers, behaviors that activate their ventral striatal reward system. Innovation also requires associative and convergent thinking, activities that are dependent on the integration of highly distributed networks. People are often most creative when they are in mental states associated with reduced levels of brain norepinephrine, which may enhance the communication between distributed networks. We, however, need to learn more about the brain mechanisms of creativity. Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Surplus Highly Enriched Uranium Disposition Program plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-10-01

The purpose of this document is to provide upper level guidance for the program that will downblend surplus highly enriched uranium for use as commercial nuclear reactor fuel or low-level radioactive waste. The intent of this document is to outline the overall mission and program objectives. The document is also intended to provide a general basis for integration of disposition efforts among all applicable sites. This plan provides background information, establishes the scope of disposition activities, provides an approach to the mission and objectives, identifies programmatic assumptions, defines major roles, provides summary level schedules and milestones, and addresses budget requirements.

Correlating student interest and high school preparation with learning and performance in an introductory university physics course

NASA Astrophysics Data System (ADS)

Harlow, Jason J. B.; Harrison, David M.; Meyertholen, Andrew

2014-06-01

We have studied the correlation of student performance in a large first year university physics course with their reasons for taking the course and whether or not the student took a senior-level high school physics course. Performance was measured both by the Force Concept Inventory and by the grade on the final examination. Students who took the course primarily for their own interest outperformed students who took the course primarily because it was required, both on the Force Concept Inventory and on the final examination; students who took a senior-level high school physics course outperformed students who did not, also both on the Force Concept Inventory and on the final exam. Students who took the course for their own interest and took high school physics outperformed students who took the course because it was required and did not take high school physics by a wide margin. However, the normalized gain on the Force Concept Inventory was the same within uncertainties for all groups and subgroups of students.

Rocking curve imaging of high quality sapphire crystals in backscattering geometry

DOE PAGES

Jafari, A.; European Synchrotron Radiation Facility; Univ. of Liege,; ...

2017-01-23

Here, we report on the characterization of high quality sapphire single crystals suitable for high-resolution X-ray optics at high energy. Investigations using rocking curve imaging reveal the crystals to be of uniformly good quality at the level of ~10 -4 in lattice parameter variations, deltad/d. But, investigations using backscattering rocking curve imaging with lattice spacing resolution of deltad/d ~ 5.10 -8 shows very diverse quality maps for all crystals. Our results highlight nearly ideal areas with edge length of 0.2-0.5 mm in most crystals, but a comparison of the back re ection peak positions shows that even neighboring ideal areasmore » exhibit a relative difference in the lattice parameters on the order of deltad/d = 10-20.10 -8; this is several times larger than the rocking curve width. Furthermore, the stress-strain analysis suggests that an extremely stringent limit on the strain at a level of ~100 kPa in the growth process is required in order to produce crystals with large areas of the quality required for X-ray optics at high energy.« less

Fire safety of wood construction

Treesearch

Robert H. White; Mark A. Dietenberger

2010-01-01

Fire safety is an important concern in all types of construction. The high level of national concern for fire safety is reflected in limitations and design requirements in building codes. These code requirements and related fire performance data are discussed in the context of fire safety design and evaluation in the initial section of this chapter. Because basic data...

10 CFR 73.51 - Requirements for the physical protection of stored spent nuclear fuel and high-level radioactive...

Code of Federal Regulations, 2010 CFR

2010-01-01

... protection program. The physical protection program review must include an evaluation of the effectiveness of... physical protection program review reports. (e) A licensee that operates a GROA is exempt from the... 10 Energy 2 2010-01-01 2010-01-01 false Requirements for the physical protection of stored spent...

Retaining Effective Urban Teachers in the Age of Accountability: How Do Successful Urban Schools Address Staffing Challenges?

ERIC Educational Resources Information Center

Davis, Cove Johnstone

2010-01-01

Many urban schools struggle to retain their best teachers because of challenging work environments, poor salaries, and ineffective school leadership. The additional requirements of the No Child Left Behind legislation for teachers to be highly qualified and the increased academic requirements of raising students to a proficient level in reading…

Workforce Planning for the Community Services and Health Industry. Occasional Paper

ERIC Educational Resources Information Center

Karmel, Tom; Blomberg, Davinia

2009-01-01

This paper aims to provide a picture of the occupations in the community services and health industry, and how the workforce obtains the required skills. The authors argue that planning for the industry should concentrate on occupations specific to the industry and those which require high skill levels. Findings suggest that the qualification…

Advanced release technologies program

NASA Technical Reports Server (NTRS)

Purdy, Bill

1994-01-01

The objective of the ARTS program was to develop lighter and less expensive spacecraft ordnance and release systems that answer to the requirements of a wide variety of spacecraft applications. These improvements were to be evaluated at the spacecraft system level, as it was determined that there were substantial system-level costs associated with the present ordnance and release subsystems. New, better devices were to be developed, then flight qualified, then integrated into a flight experiment in order to prove the reliability required for their subsequent use on high-reliability spacecraft. The secondary goal of the program was to quantify the system-level benefits of these new subsystems based upon the development program results. Three non-explosive release mechanisms and one laser-diode-based ordnance system were qualified under the program. The release devices being developed were required to release high preloads because it is easier to scale down a release mechanism than to scale it up. The laser initiator developed was required to be a direct replacement for NASA Standard Initiators, since these are the most common initiator in use presently. The program began in October, 1991, with completion of the flight experiment scheduled for February, 1994. This paper provides an overview of the ARTS program, discusses the benefits of using the ARTS components, introduces the new components, compares them with conventional systems and each other, and provides recommendations on how best to implement them.

Solidification of Savannah River plant high level waste

NASA Astrophysics Data System (ADS)

Maher, R.; Shafranek, L. F.; Kelley, J. A.; Zeyfang, R. W.

1981-11-01

Authorization for construction of the Defense Waste Processing Facility (DWPF) is expected in FY-83. The optimum time for stage 2 authorization is about three years later. Detailed design and construction will require approximately five years for stage 1, with stage 2 construction completed about two to three years later. Production of canisters of waste glass would begin in 1988, and the existing backlog of high level waste sludge stored at SRP would be worked off by about the year 2000. Stage 2 operation could begin in 1990. The technology and engineering are ready for construction and eventual operation of the DWPF for immobilizing high level radioactive waste at Savannah River Plant (SRP). Proceeding with this project will provide the public, and the leadership of this country, with a crucial demonstration that a major quanitity of existing high level nuclear wastes can be safely and permanently immobilized.

Forecasting model of Corylus, Alnus, and Betula pollen concentration levels using spatiotemporal correlation properties of pollen count.

PubMed

Nowosad, Jakub; Stach, Alfred; Kasprzyk, Idalia; Weryszko-Chmielewska, Elżbieta; Piotrowska-Weryszko, Krystyna; Puc, Małgorzata; Grewling, Łukasz; Pędziszewska, Anna; Uruska, Agnieszka; Myszkowska, Dorota; Chłopek, Kazimiera; Majkowska-Wojciechowska, Barbara

The aim of the study was to create and evaluate models for predicting high levels of daily pollen concentration of Corylus , Alnus , and Betula using a spatiotemporal correlation of pollen count. For each taxon, a high pollen count level was established according to the first allergy symptoms during exposure. The dataset was divided into a training set and a test set, using a stratified random split. For each taxon and city, the model was built using a random forest method. Corylus models performed poorly. However, the study revealed the possibility of predicting with substantial accuracy the occurrence of days with high pollen concentrations of Alnus and Betula using past pollen count data from monitoring sites. These results can be used for building (1) simpler models, which require data only from aerobiological monitoring sites, and (2) combined meteorological and aerobiological models for predicting high levels of pollen concentration.

Verification of Security Policy Enforcement in Enterprise Systems

NASA Astrophysics Data System (ADS)

Gupta, Puneet; Stoller, Scott D.

Many security requirements for enterprise systems can be expressed in a natural way as high-level access control policies. A high-level policy may refer to abstract information resources, independent of where the information is stored; it controls both direct and indirect accesses to the information; it may refer to the context of a request, i.e., the request’s path through the system; and its enforcement point and enforcement mechanism may be unspecified. Enforcement of a high-level policy may depend on the system architecture and the configurations of a variety of security mechanisms, such as firewalls, host login permissions, file permissions, DBMS access control, and application-specific security mechanisms. This paper presents a framework in which all of these can be conveniently and formally expressed, a method to verify that a high-level policy is enforced, and an algorithm to determine a trusted computing base for each resource.

Curli Fibers Are Highly Conserved between Salmonella typhimurium and Escherichia coli with Respect to Operon Structure and Regulation

PubMed Central

Römling, Ute; Bian, Zhao; Hammar, Mårten; Sierralta, Walter D.; Normark, Staffan

1998-01-01

Mouse-virulent Salmonella typhimurium strains SR-11 and ATCC 14028-1s express curli fibers, thin aggregative fibers, at ambient temperature on plates as judged by Western blot analysis and electron microscopy. Concomitantly with curli expression, cells develop a rough and dry colony morphology and bind the dye Congo red (called the rdar morphotype). Cloning and characterization of the two divergently transcribed operons required for curli biogenesis, csgBA(C) and csgDEFG, from S. typhimurium SR-11 revealed the same gene order and flanking genes as in Escherichia coli. The divergence of the curli region between S. typhimurium and E. coli at the nucleotide level is above average (22.4%). However, a high level of conservation at the protein level, which ranged from 86% amino acid homology for the fiber subunit CsgA to 99% homology for the lipoprotein CsgG, implies functional constraints on the gene products. Consequently, S. typhimurium genes on low-copy-number plasmids were able to complement respective E. coli mutants, although not always to wild-type levels. rpoS and ompR are required for transcriptional activation of (at least) the csgD promoter. The high degree of conservation at the protein level and the identical regulation patterns in E. coli and S. typhimurium suggest similar roles of curli fibers in the same ecological niche in the two species. PMID:9457880

Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold.

PubMed

Song, Ji-Yoon; Marszalek, Jaroslaw; Craig, Elizabeth Anne

2012-06-26

Fe-S clusters are critical prosthetic groups for proteins involved in various critical biological processes. Before being transferred to recipient apo-proteins, Fe-S clusters are assembled on the highly conserved scaffold protein Isu, the abundance of which is regulated posttranslationally on disruption of the cluster biogenesis system. Here we report that Isu is degraded by the Lon-type AAA+ ATPase protease of the mitochondrial matrix, Pim1. Nfs1, the cysteine desulfurase responsible for providing sulfur for cluster formation, is required for the increased Isu stability occurring after disruption of cluster formation on or transfer from Isu. Physical interaction between the Isu and Nfs1 proteins, not the enzymatic activity of Nfs1, is the important factor in increased stability. Analysis of several conditions revealed that high Isu levels can be advantageous or disadvantageous, depending on the physiological condition. During the stationary phase, elevated Isu levels were advantageous, resulting in prolonged chronological lifespan. On the other hand, under iron-limiting conditions, high Isu levels were deleterious. Compared with cells expressing normal levels of Isu, such cells grew poorly and exhibited reduced activity of the heme-containing enzyme ferric reductase. Our results suggest that modulation of the degradation of Isu by the Pim1 protease is a regulatory mechanism serving to rapidly help balance the cell's need for critical iron-requiring processes under changing environmental conditions.

High Level Mandatory Requirements

DTIC Science & Technology

2015-04-01

standards against which they are  measured.  Definition High Level Mandatory Requirements (HLMRs) describe a set of capabilities which a project  under ...capability gap (which may already be extant, which may be developing  due to a changing  strategic  environment or which may be the result of the impending...prospective project. They  are critical to successful completion of Step 2 of the BCA, which leads to the  Strategic  Context  Document. Identification

High-level waste tank farm set point document

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anthony, J.A. III

1995-01-15

Setpoints for nuclear safety-related instrumentation are required for actions determined by the design authorization basis. Minimum requirements need to be established for assuring that setpoints are established and held within specified limits. This document establishes the controlling methodology for changing setpoints of all classifications. The instrumentation under consideration involve the transfer, storage, and volume reduction of radioactive liquid waste in the F- and H-Area High-Level Radioactive Waste Tank Farms. The setpoint document will encompass the PROCESS AREA listed in the Safety Analysis Report (SAR) (DPSTSA-200-10 Sup 18) which includes the diversion box HDB-8 facility. In addition to the PROCESS AREASmore » listed in the SAR, Building 299-H and the Effluent Transfer Facility (ETF) are also included in the scope.« less

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation

PubMed Central

Keibler, Mark A.; Park, Donglim Esther; Molla, Vadim; Cheng, Jingwei; Stephanopoulos, Gregory

2016-01-01

Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells. To gain insight into cellular perturbations induced by MCPyV ST, we performed transcriptome analysis of normal human fibroblasts with inducible expression of ST. MCPyV ST dynamically alters the cellular transcriptome with increased levels of glycolytic genes, including the monocarboxylate lactate transporter SLC16A1 (MCT1). Extracellular flux analysis revealed increased lactate export reflecting elevated aerobic glycolysis in ST expressing cells. Inhibition of MCT1 activity suppressed the growth of MCC cell lines and impaired MCPyV-dependent transformation of IMR90 cells. Both NF-κB and MYC have been shown to regulate MCT1 expression. While MYC was required for MCT1 induction, MCPyV-induced MCT1 levels decreased following knockdown of the NF-κB subunit RelA, supporting a synergistic activity between MCPyV and MYC in regulating MCT1 levels. Several MCC lines had high levels of MYCL and MYCN but not MYC. Increased levels of MYCL was more effective than MYC or MYCN in increasing extracellular acidification in MCC cells. Our results demonstrate the effects of MCPyV ST on the cellular transcriptome and reveal that transformation is dependent, at least in part, on elevated aerobic glycolysis. PMID:27880818

"Assessment Drives Learning": Do Assessments Promote High-Level Cognitive Processing?

ERIC Educational Resources Information Center

Bezuidenhout, M. J.; Alt, H.

2011-01-01

Students tend to learn in the way they know, or think, they will be assessed. Therefore, to ensure deep, meaningful learning, assessments must be geared to promote cognitive processing that requires complex, contextualised thinking to construct meaning and create knowledge. Bloom's taxonomy of cognitive levels is used worldwide to assist in…

Measuring Individual Differences in Sensitivities to Basic Emotions in Faces

ERIC Educational Resources Information Center

Suzuki, Atsunobu; Hoshino, Takahiro; Shigemasu, Kazuo

2006-01-01

The assessment of individual differences in facial expression recognition is normally required to address two major issues: (1) high agreement level (ceiling effect) and (2) differential difficulty levels across emotions. We propose a new assessment method designed to quantify individual differences in the recognition of the six basic emotions,…

Global Justice and Intellectual Property Rights: Reforming the International IPR Regime for Balanced Development

ERIC Educational Resources Information Center

Salokannel, Marjut

2006-01-01

Today it is widely recognized that a uniform global intellectual property (IP) system requiring a high level of protection is inherently unjust and affects countries differently depending upon their level of technological and economic development. This article analyzes the functioning of the current international treaty framework having…

The Influence of Classroom Instruction and Test Preparation on School Accountability Levels

ERIC Educational Resources Information Center

Bryant, Karen Adair Carter

2012-01-01

Federal and state educational agencies provide guidelines for public schools across the United States to follow (Linn, 2008; Levy, 2008). During a time of high-stakes testing fueled by school accountability standards, educators strive to meet requirements for academic growth in order to maintain a successful accountability level and avoid being…

Motivational Incentives and Methylphenidate Enhance Electrophysiological Correlates of Error Monitoring in Children with Attention Deficit/Hyperactivity Disorder

ERIC Educational Resources Information Center

Groom, Madeleine J.; Liddle, Elizabeth B.; Scerif, Gaia; Liddle, Peter F.; Batty, Martin J.; Liotti, Mario; Hollis, Chris P.

2013-01-01

Background: Children with attention deficit hyperactivity disorder (ADHD) are characterised by developmentally inappropriate levels of hyperactivity, impulsivity and/or inattention and are particularly impaired when performing tasks that require a high level of cognitive control. Methylphenidate (MPH) and motivational incentives may help improve…

Heritage Language Learners' Perceptions of Acquiring and Maintaining the Spanish Language

ERIC Educational Resources Information Center

Torres, Kelly Moore; Turner, Jeannine E.

2017-01-01

The number of heritage language learners in American universities is increasing each year. Similar to monolingual students, this subgroup of learners is required to complete university level "foreign language" coursework, which can be a source of anxiety. Particularly, this subgroup of learners may experience high levels of anxiety due…

21st Century Teachers: How Non-Traditional Pre-Service Teachers Navigate Their Initial Experiences of Contemporary Classrooms

ERIC Educational Resources Information Center

Crosswell, Leanne; Beutel, Denise

2017-01-01

In the twenty-first century, teachers' work has become more complex with high levels of accountability, increased bureaucratic responsibilities and unprecedented levels of public scrutiny. However, teaching fundamentally remains a caring profession, requiring well-developed social skills and emotional labour to successfully engage and motivate…

Prospective cohort study on noise levels in a pediatric cardiac intensive care unit.

PubMed

Garcia Guerra, Gonzalo; Joffe, Ari R; Sheppard, Cathy; Pugh, Jodie; Moez, Elham Khodayari; Dinu, Irina A; Jou, Hsing; Hartling, Lisa; Vohra, Sunita

2018-04-01

To describe noise levels in a pediatric cardiac intensive care unit, and to determine the relationship between sound levels and patient sedation requirements. Prospective observational study at a pediatric cardiac intensive care unit (PCICU). Sound levels were measured continuously in slow A weighted decibels dB(A) with a sound level meter SoundEarPro® during a 4-week period. Sedation requirement was assessed using the number of intermittent (PRNs) doses given per hour. Analysis was conducted with autoregressive moving average models and the Granger test for causality. 39 children were included in the study. The average (SD) sound level in the open area was 59.4 (2.5) dB(A) with a statistically significant but clinically unimportant difference between day/night hours (60.1 vs. 58.6; p-value < 0.001). There was no significant difference between sound levels in the open area/single room (59.4 vs. 60.8, p-value = 0.108). Peak noise levels were > 90 dB. There was a significant association between average (p-value = 0.030) and peak sound levels (p-value = 0.006), and number of sedation PRNs. Sound levels were above the recommended values with no differences between day/night or open area/single room. High sound levels were significantly associated with sedation requirements. Copyright © 2017 Elsevier Inc. All rights reserved.

Design and Calibration of an RF Actuator for Low-Level RF Systems

NASA Astrophysics Data System (ADS)

Geng, Zheqiao; Hong, Bo

2016-02-01

X-ray free electron laser (FEL) machines like the Linac Coherent Light Source (LCLS) at SLAC require high-quality electron beams to generate X-ray lasers for various experiments. Digital low-level RF (LLRF) systems are widely used to control the high-power RF klystrons to provide a highly stable RF field in accelerator structures for beam acceleration. Feedback and feedforward controllers are implemented in LLRF systems to stabilize or adjust the phase and amplitude of the RF field. To achieve the RF stability and the accuracy of the phase and amplitude adjustment, low-noise and highly linear RF actuators are required. Aiming for the upgrade of the S-band Linac at SLAC, an RF actuator is designed with an I/Qmodulator driven by two digital-to-analog converters (DAC) for the digital LLRF systems. A direct upconversion scheme is selected for RF actuation, and an on-line calibration algorithm is developed to compensate the RF reference leakage and the imbalance errors in the I/Q modulator, which may cause significant phase and amplitude actuation errors. This paper presents the requirements on the RF actuator, the design of the hardware, the calibration algorithm, and the implementation in firmware and software and the test results at LCLS.

Applications of massively parallel computers in telemetry processing

NASA Technical Reports Server (NTRS)

El-Ghazawi, Tarek A.; Pritchard, Jim; Knoble, Gordon

1994-01-01

Telemetry processing refers to the reconstruction of full resolution raw instrumentation data with artifacts, of space and ground recording and transmission, removed. Being the first processing phase of satellite data, this process is also referred to as level-zero processing. This study is aimed at investigating the use of massively parallel computing technology in providing level-zero processing to spaceflights that adhere to the recommendations of the Consultative Committee on Space Data Systems (CCSDS). The workload characteristics, of level-zero processing, are used to identify processing requirements in high-performance computing systems. An example of level-zero functions on a SIMD MPP, such as the MasPar, is discussed. The requirements in this paper are based in part on the Earth Observing System (EOS) Data and Operation System (EDOS).

Student Progress to Graduation in New York City High Schools: A Metric Designed by New Visions for Public Schools. Part I: Core Components

ERIC Educational Resources Information Center

Fairchild, Susan; Gunton, Brad; Donohue, Beverly; Berry, Carolyn; Genn, Ruth; Knevals, Jessica

2011-01-01

Students who achieve critical academic benchmarks such as high attendance rates, continuous levels of credit accumulation, and high grades have a greater likelihood of success throughout high school and beyond. However, keeping students on track toward meeting graduation requirements and quickly identifying students who are at risk of falling off…

Differences among consumer segments with regard to perceptions of comparative effectiveness research.

PubMed

Williams, Sunyna S; Frost, Sloane L

2014-11-01

To examine differences among health-related decision-making consumer segments with regard to knowledge, skills, attitudes, and behaviors pertinent to comparative effectiveness research. Data were collected via an online survey from 603 adults with chronic conditions. Consumer segment was determined using a two-item tool. Active consumers (high skills and motivation) reported the highest levels of engagement in various behaviors. Passive consumers (low skills and motivation) reported the lowest levels of engagement in various behaviors. High-effort consumers (low skills, high motivation) reported more positive attitudes and opinions and more engagement in various behaviors than did complacent consumers (high skills, low motivation). Effective translation and dissemination of comparative effectiveness research will require the development of approaches tailored to consumers with varying levels of skills and motivation.

Requirements and limits for life in the context of exoplanets

PubMed Central

McKay, Christopher P.

2014-01-01

The requirements for life on Earth, its elemental composition, and its environmental limits provide a way to assess the habitability of exoplanets. Temperature is key both because of its influence on liquid water and because it can be directly estimated from orbital and climate models of exoplanetary systems. Life can grow and reproduce at temperatures as low as −15 °C, and as high as 122 °C. Studies of life in extreme deserts show that on a dry world, even a small amount of rain, fog, snow, and even atmospheric humidity can be adequate for photosynthetic production producing a small but detectable microbial community. Life is able to use light at levels less than 10−5 of the solar flux at Earth. UV or ionizing radiation can be tolerated by many microorganisms at very high levels and is unlikely to be life limiting on an exoplanet. Biologically available nitrogen may limit habitability. Levels of O2 over a few percent on an exoplanet would be consistent with the presence of multicellular organisms and high levels of O2 on Earth-like worlds indicate oxygenic photosynthesis. Other factors such as pH and salinity are likely to vary and not limit life over an entire planet or moon. PMID:24927538

Requirements and limits for life in the context of exoplanets.

PubMed

McKay, Christopher P

2014-09-02

The requirements for life on Earth, its elemental composition, and its environmental limits provide a way to assess the habitability of exoplanets. Temperature is key both because of its influence on liquid water and because it can be directly estimated from orbital and climate models of exoplanetary systems. Life can grow and reproduce at temperatures as low as -15 °C, and as high as 122 °C. Studies of life in extreme deserts show that on a dry world, even a small amount of rain, fog, snow, and even atmospheric humidity can be adequate for photosynthetic production producing a small but detectable microbial community. Life is able to use light at levels less than 10(-5) of the solar flux at Earth. UV or ionizing radiation can be tolerated by many microorganisms at very high levels and is unlikely to be life limiting on an exoplanet. Biologically available nitrogen may limit habitability. Levels of O2 over a few percent on an exoplanet would be consistent with the presence of multicellular organisms and high levels of O2 on Earth-like worlds indicate oxygenic photosynthesis. Other factors such as pH and salinity are likely to vary and not limit life over an entire planet or moon.

Enhanced LAW Glass Correlation - Phase 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muller, Isabelle S.; Matlack, Keith S.; Pegg, Ian L.

About 50 million gallons of high-level mixed waste is currently stored in underground tanks at the United States Department of Energy’s (DOE’s) Hanford site in the State of Washington. The Hanford Tank Waste Treatment and Immobilization Plant (WTP) will provide DOE’s Office of River Protection (ORP) with a means of treating this waste by vitrification for subsequent disposal. The tank waste will be separated into low- and high-activity waste fractions, which will then be vitrified respectively into Immobilized Low Activity Waste (ILAW) and Immobilized High Level Waste (IHLW) products. The ILAW product will be disposed in an engineered facility onmore » the Hanford site while the IHLW product is designed for acceptance into a national deep geological disposal facility for high-level nuclear waste. The ILAW and IHLW products must meet a variety of requirements with respect to protection of the environment before they can be accepted for disposal. Acceptable glass formulations for vitrification of Hanford low activity waste (LAW) must meet a variety of product quality, processability, and waste loading requirements. To this end, The Vitreous State Laboratory (VSL) at The Catholic University of America (CUA) developed and tested a number of glass formulations during Part A, Part B1 and Part B2 of the WTP development program. The testing resulted in the selection of target glass compositions for the processing of eight of the Phase I LAW tanks. The selected glass compositions were tested at the crucible scale to confirm their compliance with ILAW performance requirements. Duramelter 100 (DM100) and LAW Pilot Melter tests were then conducted to demonstrate the viability of these glass compositions for LAW vitrification at high processing rates.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aschengrau, A.; Zierler, S.; Cohen, A.

To investigate the relationship between community drinking water quality and spontaneous abortion, we compared trace element levels in the drinking water of 286 women having a spontaneous abortion through 27 wk gestation with that of 1,391 women having live births. Trace element levels were gathered from analyses of public tap water supplies from the communities where the women resided during pregnancy. After adjustment for potential confounders, an increase in the frequency of spontaneous abortion was associated with detectable levels of mercury; high levels of arsenic, potassium, and silica; moderately hard water, and surface water. In contrast, a decrease in themore » frequency of spontaneous abortion was associated with high levels of alkalinity and sulfate, and any detectable level of nitrate. These results require further corroboration because there is a paucity of data investigating this issue.« less

Evaluation of groundwater levels in the South Platte River alluvial aquifer, Colorado, 1953-2012, and design of initial well networks for monitoring groundwater levels

USGS Publications Warehouse

Wellman, Tristan

2015-01-01

A network of candidate monitoring wells was proposed to initiate a regional monitoring program. Consistent monitoring and analysis of groundwater levels will be needed for informed decisions to optimize beneficial use of water and to limit high groundwater levels in susceptible areas. Finalization of the network will require future field reconnaissance to assess local site conditions and discussions with State authorities.

Civilian Radioactive Waste Management System Requirements Document

DOE Office of Scientific and Technical Information (OSTI.GOV)

C.A. Kouts

2006-05-10

The CRD addresses the requirements of Department of Energy (DOE) Order 413.3-Change 1, ''Program and Project Management for the Acquisition of Capital Assets'', by providing the Secretarial Acquisition Executive (Level 0) scope baseline and the Program-level (Level 1) technical baseline. The Secretarial Acquisition Executive approves the Office of Civilian Radioactive Waste Management's (OCRWM) critical decisions and changes against the Level 0 baseline; and in turn, the OCRWM Director approves all changes against the Level 1 baseline. This baseline establishes the top-level technical scope of the CRMWS and its three system elements, as described in section 1.3.2. The organizations responsible formore » design, development, and operation of system elements described in this document must therefore prepare subordinate project-level documents that are consistent with the CRD. Changes to requirements will be managed in accordance with established change and configuration control procedures. The CRD establishes requirements for the design, development, and operation of the CRWMS. It specifically addresses the top-level governing laws and regulations (e.g., ''Nuclear Waste Policy Act'' (NWPA), 10 Code of Federal Regulations (CFR) Part 63, 10 CFR Part 71, etc.) along with specific policy, performance requirements, interface requirements, and system architecture. The CRD shall be used as a vehicle to incorporate specific changes in technical scope or performance requirements that may have significant program implications. Such may include changes to the program mission, changes to operational capability, and high visibility stakeholder issues. The CRD uses a systems approach to: (1) identify key functions that the CRWMS must perform, (2) allocate top-level requirements derived from statutory, regulatory, and programmatic sources, and (3) define the basic elements of the system architecture and operational concept. Project-level documents address CRD requirements by further defining system element functions, decomposing requirements into significantly greater detail, and developing designs of system components, facilities, and equipment. The CRD addresses the identification and control of functional, physical, and operational boundaries between and within CRWMS elements. The CRD establishes requirements regarding key interfaces between the CRWMS and elements external to the CRWMS. Project elements define interfaces between CRWMS program elements. The Program has developed a change management process consistent with DOE Order 413.3-Change 1. Changes to the Secretarial Acquisition Executive and Program-level baselines must be approved by a Program Baseline Change Control Board. Specific thresholds have been established for identifying technical, cost, and schedule changes that require approval. The CRWMS continually evaluates system design and operational concepts to optimize performance and/or cost. The Program has developed systems analysis tools to assess potential enhancements to the physical system and to determine the impacts from cost saving initiatives, scientific and technological improvements, and engineering developments. The results of systems analyses, if appropriate, are factored into revisions to the CRD as revised Programmatic Requirements.« less

System Definition Document

DOT National Transportation Integrated Search

1996-06-12

The Gary-Chicago-Milwaukee (GCM) Corridor Transportation Information Center : (C-TIC) System Definition Document describes the C-TIC concept and defines the : high level processes and dataflows. The Requirements Specification together : with the Inte...

76 FR 40937 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

... Generator Water Level High-High'' instrument setpoint and associated allowable value. The proposed change is... [Pressurized-Water Reactor] PWR Operability Requirements and Actions for RCS Leakage Instrumentation''. Basis... monitor is the containment atmospheric gaseous radiation monitor. The monitoring of RCS leakage is not a...

Learning by Self-Explaining Causal Diagrams in High-School Biology

ERIC Educational Resources Information Center

Cho, Young Hoan; Jonassen, David H.

2012-01-01

Understanding scientific phenomena requires comprehension and application of the underlying causal relationships that describe those phenomena (Carey 2002). The current study examined the roles of self-explanation and meta-level feedback for understanding causal relationships described in a causal diagram. In this study, 63 Korean high-school…

Incorporating High-Throughput Exposure Predictions with Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

EPA Science Inventory

We previously integrated dosimetry and exposure with high-throughput screening (HTS) to enhance the utility of ToxCast™ HTS data by translating in vitro bioactivity concentrations to oral equivalent doses (OEDs) required to achieve these levels internally. These OEDs were compare...

14 CFR 25.145 - Longitudinal control.

Code of Federal Regulations, 2014 CFR

2014-01-01

... complete retraction of the high lift devices from any position is begun during steady, straight, level... retractions of the high-lift devices from any position from the maximum landing position to the first gated... requirements of paragraph (c) of this section also apply to retractions from each approved landing position to...

14 CFR 25.145 - Longitudinal control.

Code of Federal Regulations, 2013 CFR

2013-01-01

... complete retraction of the high lift devices from any position is begun during steady, straight, level... retractions of the high-lift devices from any position from the maximum landing position to the first gated... requirements of paragraph (c) of this section also apply to retractions from each approved landing position to...

Rice University: Innovation to Increase Student College Readiness

ERIC Educational Resources Information Center

Gigliotti, Jennifer

2012-01-01

"College readiness" means that a student can enter a college classroom without remediation and successfully complete entry-level college requirements (Conley, 2012). In order for students to be considered college ready, they must acquire skills, content knowledge, and behaviors before leaving high school. Research on high-school performance…

High-speed civil transport study: Special factors

NASA Technical Reports Server (NTRS)

1990-01-01

Studies relating to environmental factors associated with high speed civil transports were conducted. Projected total engine emissions for year 2015 fleets of several subsonic/supersonic transport fleet scenarios, discussion of sonic boom reduction methods, discussion of community noise level requirements, fuels considerations, and air traffic control impact are presented.

GUIDE FOR OPPORTUNITY CLASSES.

ERIC Educational Resources Information Center

JENNINGS, H. MARVIN; AND OTHERS

TO MEET THE NEEDS OF THE SLOW LEARNER AT THE SECONDARY LEVELS, CAREFULLY PLANNED AND TESTED GUIDELINES ARE SET FORTH FOR SELECTION OF PUPILS, STANDARDS FOR GRADING, AND GRADUATION REQUIREMENTS. LESSON PLANS AND SUGGESTIONS, MATERIALS, AND TEXTBOOKS ARE INCLUDED. COURSES COVERED ARE LANGUAGE ARTS, JUNIOR HIGH ARITHMETIC, MATHEMATICS IN HIGH SCHOOL,…

Concept development and needs identification for intelligent network flow optimization (INFLO) : functional and performance requirements, and high-level data and communication needs.

DOT National Transportation Integrated Search

2012-11-01

The purpose of this project is to develop for the Intelligent Network Flow Optimization (INFLO), which is one collection (or bundle) of high-priority transformative applications identified by the United States Department of Transportation (USDOT) Mob...

Interior noise control prediction study for high-speed propeller-driven aircraft

NASA Technical Reports Server (NTRS)

Rennison, D. C.; Wilby, J. F.; Marsh, A. H.; Wilby, E. G.

1979-01-01

An analytical model was developed to predict the noise levels inside propeller-driven aircraft during cruise at M = 0.8. The model was applied to three study aircraft with fuselages of different size (wide body, narrow body and small diameter) in order to determine the noise reductions required to achieve the goal of an A-weighted sound level which does not exceed 80 dB. The model was then used to determine noise control methods which could achieve the required noise reductions. Two classes of noise control treatments were investigated: add-on treatments which can be added to existing structures, and advanced concepts which would require changes to the fuselage primary structure. Only one treatment, a double wall with limp panel, provided the required noise reductions. Weight penalties associated with the treatment were estimated for the three study aircraft.

GA-optimization for rapid prototype system demonstration

NASA Technical Reports Server (NTRS)

Kim, Jinwoo; Zeigler, Bernard P.

1994-01-01

An application of the Genetic Algorithm (GA) is discussed. A novel scheme of Hierarchical GA was developed to solve complicated engineering problems which require optimization of a large number of parameters with high precision. High level GAs search for few parameters which are much more sensitive to the system performance. Low level GAs search in more detail and employ a greater number of parameters for further optimization. Therefore, the complexity of the search is decreased and the computing resources are used more efficiently.

Lead paint removal with high-intensity light pulses.

PubMed

Grapperhaus, Michael J; Schaefer, Raymond B

2006-12-15

This paper presents the results of an initial investigation into using high-intensity incoherent light pulses to strip paint. Measurements of light pulse characteristics, the reflectivity of different paints and initial experiments on the threshold for paint removal, and paint removal are presented, along with an approximate model consistent with experimental results. Paint removal tests include lead paint, the reduction of lead levels to below levels required for lead abatement, as well as air and light emissions measurements that are within regulatory guidelines.

Prediction of the interior noise levels of high-speed propeller-driven aircraft

NASA Technical Reports Server (NTRS)

Rennison, D. C.; Wilby, J. F.; Wilby, E. G.

1980-01-01

The theoretical basis for an analytical model developed to predict the interior noise levels of high-speed propeller-driven airplanes is presented. Particular emphasis is given to modeling the transmission of discrete tones through a fuselage element into a cavity, estimates for the mean and standard deviation of the acoustic power flow, the coupling between a non-homogeneous excitation and the fuselage vibration response, and the prediction of maximum interior noise levels. The model allows for convenient examination of the various roles of the excitation and fuselage structural characteristics on the fuselage vibration response and the interior noise levels, as is required for the design of model or prototype noise control validation tests.

Functional Requirements Document for HALE UAS Operations in the NAS: Step 1. Version 3

NASA Technical Reports Server (NTRS)

2006-01-01

The purpose of this Functional Requirements Document (FRD) is to compile the functional requirements needed to achieve the Access 5 Vision of "operating High Altitude, Long Endurance (HALE) Unmanned Aircraft Systems (UAS) routinely, safely, and reliably in the national airspace system (NAS)" for Step 1. These functional requirements could support the development of a minimum set of policies, procedures and standards by the Federal Aviation Administration (FAA) and various standards organizations. It is envisioned that this comprehensive body of work will enable the FAA to establish and approve regulations to govern safe operation of UAS in the NAS on a routine or daily "file and fly" basis. The approach used to derive the functional requirements found within this FRD was to decompose the operational requirements and objectives identified within the Access 5 Concept of Operations (CONOPS) into the functions needed to routinely and safely operate a HALE UAS in the NAS. As a result, four major functional areas evolved to enable routine and safe UAS operations for an on-demand basis in the NAS. These four major functions are: Aviate, Navigate, Communicate, and Avoid Hazards. All of the functional requirements within this document can be directly traceable to one of these four major functions. Some functions, however, are traceable to several, or even all, of these four major functions. These cross-cutting functional requirements support the "Command / Control: function as well as the "Manage Contingencies" function. The requirements associated to these high-level functions and all of their supporting low-level functions are addressed in subsequent sections of this document.

Solar Electric Propulsion for Future NASA Missions

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.; Oleson, Steven R.; Mercer, Carolyn R.

2015-01-01

Use of high-power solar arrays, at power levels ranging from approximately 500 KW to several megawatts, has been proposed for a solar-electric propulsion (SEP) demonstration mission, using a photovoltaic array to provide energy to a high-power xenon-fueled engine. One of the proposed applications of the high-power SEP technology is a mission to rendezvous with an asteroid and move it into lunar orbit for human exploration, the Asteroid Retrieval mission. The Solar Electric Propulsion project is dedicated to developing critical technologies to enable trips to further away destinations such as Mars or asteroids. NASA needs to reduce the cost of these ambitious exploration missions. High power and high efficiency SEP systems will require much less propellant to meet those requirements.

Virtual groups for patient WBAN monitoring in medical environments.

PubMed

Ivanov, Stepan; Foley, Christopher; Balasubramaniam, Sasitharan; Botvich, Dmitri

2012-11-01

Wireless body area networks (WBAN) provide a tremendous opportunity for remote health monitoring. However, engineering WBAN health monitoring systems encounters a number of challenges including efficient WBAN monitoring information extraction, dynamically fine tuning the monitoring process to suit the quality of data, and to allow the translation of high-level requirements of medical officers to low-level sensor reconfiguration. This paper addresses these challenges, by proposing an architecture that allows virtual groups to be formed between devices of patients, nurses, and doctors in order to enable remote analysis of WBAN data. Group formation and modification is performed with respect to patients' conditions and medical officers' requirements, which could be easily adjusted through high-level policies. We also propose, a new metric called the Quality of Health Monitoring, which allows medical officers to provide feedback on the quality of WBAN data received. The WBAN data gathered are transmitted to the virtual group members through an underlying environmental sensor network. The proposed approach is evaluated through a series of simulation.

High level waste storage tank farms/242-A evaporator standards/requirements identification document phase 1 assessment corrective actions/compliance schedule approval report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biebesheimer, E.

This document, the Standards/Requirements Identification Document (S/RID) Phase I Assessment Corrective Actions/Compliance Schedule Approval Report for the subject facility, contains the corrective actions required to bring the facility into compliance as a result of an Administrative Assessment to determine whether S/RID requirements are fully addressed by existing policies, plans or procedures. These actions are delineated in the Compliance Schedule Approvals which also contain; noncompliances, risks, compensatory measures, schedules for corrective actions, justifications for approval, and resource impacts.

Power Control and Monitoring Requirements for Thermal Vacuum/Thermal Balance Testing of the MAP Observatory

NASA Technical Reports Server (NTRS)

Johnson, Chris; Hinkle, R. Kenneth (Technical Monitor)

2002-01-01

The specific heater control requirements for the thermal vacuum and thermal balance testing of the Microwave Anisotropy Probe (MAP) Observatory at the Goddard Space Flight Center (GSFC) in Greenbelt, Maryland are described. The testing was conducted in the 10m wide x 18.3m high Space Environment Simulator (SES) Thermal Vacuum Facility. The MAP thermal testing required accurate quantification of spacecraft and fixture power levels while minimizing heater electrical emissions. The special requirements of the MAP test necessitated construction of five (5) new heater racks.

Evaluation of components, subsystems, and networks for high rate, high frequency space communications

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Ivancic, William D.; Zuzek, John E.

1991-01-01

The development of new space communications technologies by NASA has included both commercial applications and space science requirements. At NASA's Lewis Research Center, methods and facilities have been developed for evaluating these new technologies in the laboratory. NASA's Systems Integration, Test and Evaluation (SITE) Space Communication System Simulator is a hardware-based laboratory simulator for evaluating space communications technologies at the component, subsystem, system, and network level, geared toward high frequency, high data rate systems. The SITE facility is well-suited for evaluation of the new technologies required for the Space Exploration Initiative (SEI) and advanced commercial systems. This paper describes the technology developments and evaluation requirements for current and planned commercial and space science programs. Also examined are the capabilities of SITE, the past, present, and planned future configurations of the SITE facility, and applications of SITE to evaluation of SEI technology.

Predictors of poor outcome in gastrointestinal bleeding in emergency department.

PubMed

Kaya, Ender; Karaca, Mehmet Ali; Aldemir, Deniz; Ozmen, M Mahir

2016-04-28

To determine the prognostic risk factors of gastrointestinal bleeding in emergency department cases. The trial was a retrospective single-center study involving 600 patients over 18-years-old and carried out with approval by the Institutional Ethics Committee. Patient data included demographic characteristics, symptoms at admission, past medical history, vital signs, laboratory results, endoscopy and colonoscopy results, length of hospital stay, need of intensive care unit (ICU) admission, and mortality. Mortality rate was the principal endpoint of the study, while duration of hospital stay, required interventional treatment, and admission to the ICU were secondary endpoints. The mean age of patients was 61.92-years-old. Among the 600 total patients, 363 (60.5%) underwent upper gastrointestinal endoscopy and the most frequent diagnoses were duodenal ulcer (19.2%) and gastric ulcer (12.8%). One-hundred-and-fifteen (19.2%) patients required endoscopic treatment, 20 (3.3%) required surgical treatment, and 5 (0.8%) required angiographic embolization. The mean length of hospital stay was 5.21 ± 5.85 d. The mortality rate was 6.3%. The ICU admission rate was 5.3%. Patients with syncope, higher blood glucose levels, and coronary artery disease had significantly higher ICU admission rates (P = 0.029, P = 0.043, and P = 0.002, respectively). Patients with low thrombocyte levels, high creatinine, high international normalized ratio, and high serum transaminase levels had significantly longer hospital stay (P = 0.02, P = 0.001, P = 0.019, and P = 0.005, respectively). Patients who died had significantly higher serum blood urea nitrogen and creatinine levels (P = 0.016 and P = 0.038), and significantly lower mean blood pressure and oxygen saturation (P = 0.004 and P = 0.049). Malignancy and low Glasgow coma scale (GCS) were independent predictive factors of mortality. Prognostic factors for gastrointestinal bleeding in emergency room cases are malignancy, hypotension on admission, low GCS, and impaired kidney function.

State but not district nutrition policies are associated with less junk food in vending machines and school stores in US public schools.

PubMed

Kubik, Martha Y; Wall, Melanie; Shen, Lijuan; Nanney, Marilyn S; Nelson, Toben F; Laska, Melissa N; Story, Mary

2010-07-01

Policy that targets the school food environment has been advanced as one way to increase the availability of healthy food at schools and healthy food choice by students. Although both state- and district-level policy initiatives have focused on school nutrition standards, it remains to be seen whether these policies translate into healthy food practices at the school level, where student behavior will be impacted. To examine whether state- and district-level nutrition policies addressing junk food in school vending machines and school stores were associated with less junk food in school vending machines and school stores. Junk food was defined as foods and beverages with low nutrient density that provide calories primarily through fats and added sugars. A cross-sectional study design was used to assess self-report data collected by computer-assisted telephone interviews or self-administered mail questionnaires from state-, district-, and school-level respondents participating in the School Health Policies and Programs Study 2006. The School Health Policies and Programs Study, administered every 6 years since 1994 by the Centers for Disease Control and Prevention, is considered the largest, most comprehensive assessment of school health policies and programs in the United States. A nationally representative sample (n=563) of public elementary, middle, and high schools was studied. Logistic regression adjusted for school characteristics, sampling weights, and clustering was used to analyze data. Policies were assessed for strength (required, recommended, neither required nor recommended prohibiting junk food) and whether strength was similar for school vending machines and school stores. School vending machines and school stores were more prevalent in high schools (93%) than middle (84%) and elementary (30%) schools. For state policies, elementary schools that required prohibiting junk food in school vending machines and school stores offered less junk food than elementary schools that neither required nor recommended prohibiting junk food (13% vs 37%; P=0.006). Middle schools that required prohibiting junk food in vending machines and school stores offered less junk food than middle schools that recommended prohibiting junk food (71% vs 87%; P=0.07). Similar associations were not evident for district-level polices or high schools. Policy may be an effective tool to decrease junk food in schools, particularly in elementary and middle schools. Copyright 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved.

State but not District Nutrition Policies Are Associated with Less Junk Food in Vending Machines and School Stores in US Public Schools

PubMed Central

KUBIK, MARTHA Y.; WALL, MELANIE; SHEN, LIJUAN; NANNEY, MARILYN S.; NELSON, TOBEN F.; LASKA, MELISSA N.; STORY, MARY

2012-01-01

Background Policy that targets the school food environment has been advanced as one way to increase the availability of healthy food at schools and healthy food choice by students. Although both state- and district-level policy initiatives have focused on school nutrition standards, it remains to be seen whether these policies translate into healthy food practices at the school level, where student behavior will be impacted. Objective To examine whether state- and district-level nutrition policies addressing junk food in school vending machines and school stores were associated with less junk food in school vending machines and school stores. Junk food was defined as foods and beverages with low nutrient density that provide calories primarily through fats and added sugars. Design A cross-sectional study design was used to assess self-report data collected by computer-assisted telephone interviews or self-administered mail questionnaires from state-, district-, and school-level respondents participating in the School Health Policies and Programs Study 2006. The School Health Policies and Programs Study, administered every 6 years since 1994 by the Centers for Disease Control and Prevention, is considered the largest, most comprehensive assessment of school health policies and programs in the United States. Subjects/setting A nationally representative sample (n = 563) of public elementary, middle, and high schools was studied. Statistical analysis Logistic regression adjusted for school characteristics, sampling weights, and clustering was used to analyze data. Policies were assessed for strength (required, recommended, neither required nor recommended prohibiting junk food) and whether strength was similar for school vending machines and school stores. Results School vending machines and school stores were more prevalent in high schools (93%) than middle (84%) and elementary (30%) schools. For state policies, elementary schools that required prohibiting junk food in school vending machines and school stores offered less junk food than elementary schools that neither required nor recommended prohibiting junk food (13% vs 37%; P = 0.006). Middle schools that required prohibiting junk food in vending machines and school stores offered less junk food than middle schools that recommended prohibiting junk food (71% vs 87%; P = 0.07). Similar associations were not evident for district-level polices or high schools. Conclusions Policy may be an effective tool to decrease junk food in schools, particularly in elementary and middle schools. PMID:20630161

Current (2004-07) Conditions and Changes in Ground-Water Levels from Predevelopment to 2007, Southern High Plains Aquifer, Southeast New Mexico-Lea County Underground Water Basin

USGS Publications Warehouse

Tillery, Anne

2008-01-01

The Southern High Plains aquifer is the principal aquifer and primary source of water in southeastern New Mexico. The Lea County portion of the aquifer covers approximately the northern two thirds of the 4,393-square-mile county. Successful water-supply planning for New Mexico's Southern High Plains requires knowledge of the current aquifer conditions and a context from which to estimate future trends given current aquifer-management policy. Maps representing water-level declines, current (2007) water levels, aquifer saturated thickness, and depth to water accompanied by hydrographs from representative wells for the Southern High Plains aquifer in the Lea County Underground Water Basin were prepared in cooperation with the New Mexico Office of the State Engineer. Results of this mapping effort show the water level has declined as much as 97 feet in the Lea County Underground Water Basin from predevelopment (1914-54) to 2007 with rates as high as 0.88 feet per year.

Heightened aggression and winning contests increase corticosterone but decrease testosterone in male Australian water dragons.

PubMed

Baird, Troy A; Lovern, Matthew B; Shine, Richard

2014-07-01

Water dragons (Intellegama [Physignathus] lesueurii) are large (to >1m) agamid lizards from eastern Australia. Males are fiercely combative; holding a territory requires incessant displays and aggression against other males. If a dominant male is absent, injured or fatigued, another male soon takes over his territory. Our sampling of blood from free-ranging adult males showed that baseline levels of both testosterone and corticosterone were not related to a male's social tactic (territorial versus non-territorial), or his frequency of advertisement display, aggression, or courtship behavior. Even when we elicited intense aggression by non-territorial males (by temporarily removing territory owners), testosterone did not increase with the higher levels of aggression that ensued. Indeed, testosterone levels decreased in males that won contests. In contrast, male corticosterone levels increased with the heightened aggression during unsettled conditions, and were higher in males that won contests. High chronic male-male competition in this dense population may favor high testosterone levels in all adult males to facilitate advertisement and patrol activities required for territory maintenance (by dominant animals), and to maintain readiness for territory take-overs (in non-territorial animals). Corticosterone levels increased in response to intense aggression during socially unstable conditions, and were higher in contest winners than losers. A positive correlation between the two hormones during socially unstable conditions suggests that the high stress of contests decreased androgen production. The persistent intense competition in this population appears to exact a high physiological cost, which together with our observation that males sometimes lose their territories to challengers may indicate cycling between these two tactics to manage long-term energetic costs. Copyright © 2014 Elsevier Inc. All rights reserved.

Homologous Recombination Repair Factors Rad51 and BRCA1 Are Necessary for Productive Replication of Human Papillomavirus 31

PubMed Central

Chappell, William H.; Gautam, Dipendra; Ok, Suzan T.; Johnson, Bryan A.; Anacker, Daniel C.

2015-01-01

ABSTRACT High-risk human papillomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage response (DDR), which is necessary for productive viral replication. In response to DNA double-strand breaks (DSBs), ATM activation leads to DNA repair through homologous recombination (HR), which requires the principal recombinase protein Rad51, as well as BRCA1. Previous studies from our lab demonstrated that Rad51 and BRCA1 are expressed at high levels in HPV31-positive cells and localize to sites of viral replication. These results suggest that HPV may utilize ATM activity to increase HR activity as a means to facilitate viral replication. In this study, we demonstrate that high-risk HPV E7 expression alone is sufficient for the increase in Rad51 and BRCA1 protein levels. We have found that this increase occurs, at least in part, at the level of transcription. Studies analyzing protein stability indicate that HPV may also protect Rad51 and BRCA1 from turnover, contributing to the overall increase in cellular levels. We also demonstrate that Rad51 is bound to HPV31 genomes, with binding increasing per viral genome upon productive replication. We have found that depletion of Rad51 and BRCA1, as well as inhibition of Rad51's recombinase activity, abrogates productive viral replication upon differentiation. Overall, these results indicate that Rad51 and BRCA1 are required for the process of HPV31 genome amplification and suggest that productive replication occurs in a manner dependent upon recombination. IMPORTANCE Productive replication of HPV31 requires activation of an ATM-dependent DNA damage response, though how ATM activity contributes to replication is unclear. Rad51 and BRCA1 play essential roles in repair of double-strand breaks, as well as the restart of stalled replication forks through homologous recombination (HR). Given that ATM activity is required to initiate HR repair, coupled with the requirement of Rad51 and BRCA1 for productive viral replication, our findings suggest that HPV may utilize ATM activity to ensure localization of recombination factors to productively replicating viral genomes. The finding that E7 increases the levels of Rad51 and BRCA1 suggests that E7 contributes to productive replication by providing DNA repair factors required for viral DNA synthesis. Our studies not only imply a role for recombination in the regulation of productive HPV replication but provide further insight into how HPV manipulates the DDR to facilitate the productive phase of the viral life cycle. PMID:26699641

Harnessing QbD, Programming Languages, and Automation for Reproducible Biology.

PubMed

Sadowski, Michael I; Grant, Chris; Fell, Tim S

2016-03-01

Building robust manufacturing processes from biological components is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and administrate management of knowledge, data, and materials. We argue that for bioengineering to fully access biological potential, it will require application of statistically designed experiments to derive detailed empirical models of underlying systems. This requires execution of large-scale structured experimentation for which laboratory automation is necessary. This requires development of expressive, high-level languages that allow reusability of protocols, characterization of their reliability, and a change in focus from implementation details to functional properties. We review recent developments in these areas and identify what we believe is an exciting trend that promises to revolutionize biotechnology. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

A Study of Emotions in Requirements Engineering

NASA Astrophysics Data System (ADS)

Colomo-Palacios, Ricardo; Hernández-López, Adrián; García-Crespo, Ángel; Soto-Acosta, Pedro

Requirements engineering (RE) is a crucial activity in software development projects. This phase in the software development cycle is knowledge intensive, and thus, human capital intensive. From the human point of view, emotions play an important role in behavior and can even act as behavioral motivators. Thus, if we consider that RE represents a set of knowledge-intensive tasks, which include acceptance and negotiation activities, then the emotional factor represents a key element in these issues. However, the emotional factor in RE has not received the attention it deserves. This paper aims to integrate the stakeholder's emotions into the requirement process, proposing to catalogue them like any other factor in the process such as clarity or stability. Results show that high arousal and low pleasure levels are predictors of high versioning requirements.

Economic Metrics for Commercial Reusable Space Transportation Systems

NASA Technical Reports Server (NTRS)

Shaw, Eric J.; Hamaker, Joseph (Technical Monitor)

2000-01-01

The success of any effort depends upon the effective initial definition of its purpose, in terms of the needs to be satisfied and the goals to be fulfilled. If the desired product is "A System" that is well-characterized, these high-level need and goal statements can be transformed into system requirements by traditional systems engineering techniques. The satisfaction of well-designed requirements can be tracked by fairly straightforward cost, schedule, and technical performance metrics. Unfortunately, some types of efforts, including those that NASA terms "Programs," tend to resist application of traditional systems engineering practices. In the NASA hierarchy of efforts, a "Program" is often an ongoing effort with broad, high-level goals and objectives. A NASA "project" is a finite effort, in terms of budget and schedule, that usually produces or involves one System. Programs usually contain more than one project and thus more than one System. Special care must be taken in the formulation of NASA Programs and their projects, to ensure that lower-level project requirements are traceable to top-level Program goals, feasible with the given cost and schedule constraints, and measurable against top-level goals. NASA Programs and projects are tasked to identify the advancement of technology as an explicit goal, which introduces more complicating factors. The justification for funding of technology development may be based on the technology's applicability to more than one System, Systems outside that Program or even external to NASA. Application of systems engineering to broad-based technology development, leading to effective measurement of the benefits, can be valid, but it requires that potential beneficiary Systems be organized into a hierarchical structure, creating a "system of Systems." In addition, these Systems evolve with the successful application of the technology, which creates the necessity for evolution of the benefit metrics to reflect the changing baseline. Still, economic metrics for technology development in these Programs and projects remain fairly straightforward, being based on reductions in acquisition and operating costs of the Systems. One of the most challenging requirements that NASA levies on its Programs is to plan for the commercialization of the developed technology. Some NASA Programs are created for the express purpose of developing technology for a particular industrial sector, such as aviation or space transportation, in financial partnership with that sector. With industrial investment, another set of goals, constraints and expectations are levied on the technology program. Economic benefit metrics then expand beyond cost and cost savings to include the marketability, profit, and investment return requirements of the private sector. Commercial investment criteria include low risk, potential for high return, and strategic alignment with existing product lines. These corporate criteria derive from top-level strategic plans and investment goals, which rank high among the most proprietary types of information in any business. As a result, top-level economic goals and objectives that industry partners bring to cooperative programs cannot usually be brought into technical processes, such as systems engineering, that are worked collaboratively between Industry and Government. In spite of these handicaps, the top-level economic goals and objectives of a joint technology program can be crafted in such a way that they accurately reflect the fiscal benefits from both Industry and Government perspectives. Valid economic metrics can then be designed that can track progress toward these goals and objectives, while maintaining the confidentiality necessary for the competitive process.

Formation Control for the Maxim Mission.

NASA Technical Reports Server (NTRS)

Luquette, Richard J.; Leitner, Jesse; Gendreau, Keith; Sanner, Robert M.

2004-01-01

Over the next twenty years, a wave of change is occurring in the spacebased scientific remote sensing community. While the fundamental limits in the spatial and angular resolution achievable in spacecraft have been reached, based on today's technology, an expansive new technology base has appeared over the past decade in the area of Distributed Space Systems (DSS). A key subset of the DSS technology area is that which covers precision formation flying of space vehicles. Through precision formation flying, the baselines, previously defined by the largest monolithic structure which could fit in the largest launch vehicle fairing, are now virtually unlimited. Several missions including the Micro-Arcsecond X-ray Imaging Mission (MAXIM), and the Stellar Imager will drive the formation flying challenges to achieve unprecedented baselines for high resolution, extended-scene, interferometry in the ultraviolet and X-ray regimes. This paper focuses on establishing the feasibility for the formation control of the MAXIM mission. The Stellar Imager mission requirements are on the same order of those for MAXIM. This paper specifically addresses: (1) high-level science requirements for these missions and how they evolve into engineering requirements; (2) the formation control architecture devised for such missions; (3) the design of the formation control laws to maintain very high precision relative positions; and (4) the levels of fuel usage required in the duration of these missions. Specific preliminary results are presented for two spacecraft within the MAXIM mission.

Relevance feedback-based building recognition

NASA Astrophysics Data System (ADS)

Li, Jing; Allinson, Nigel M.

2010-07-01

Building recognition is a nontrivial task in computer vision research which can be utilized in robot localization, mobile navigation, etc. However, existing building recognition systems usually encounter the following two problems: 1) extracted low level features cannot reveal the true semantic concepts; and 2) they usually involve high dimensional data which require heavy computational costs and memory. Relevance feedback (RF), widely applied in multimedia information retrieval, is able to bridge the gap between the low level visual features and high level concepts; while dimensionality reduction methods can mitigate the high-dimensional problem. In this paper, we propose a building recognition scheme which integrates the RF and subspace learning algorithms. Experimental results undertaken on our own building database show that the newly proposed scheme appreciably enhances the recognition accuracy.

Scheduling language and algorithm development study. Volume 1: Study summary and overview

NASA Technical Reports Server (NTRS)

1974-01-01

A high level computer programming language and a program library were developed to be used in writing programs for scheduling complex systems such as the space transportation system. The objectives and requirements of the study are summarized and unique features of the specified language and program library are described and related to the why of the objectives and requirements.

Targeted Support and Telecare in Staffed Housing for People with Intellectual Disabilities: Impact on Staffing Levels and Objective Lifestyle Indicators

ERIC Educational Resources Information Center

Perry, Jonathan; Firth, Caroline; Puppa, Michael; Wilson, Rick; Felce, David

2012-01-01

Background: Increased provision of out-of-family residential support is required because of demographic changes within the intellectual disabilities population. Residential support now has to be provided in a climate requiring both financial constraint and high quality service outcomes. The aim was to evaluate the quality of life consequences of…

Universal computer test stand (recommended computer test requirements). [for space shuttle computer evaluation

NASA Technical Reports Server (NTRS)

1973-01-01

Techniques are considered which would be used to characterize areospace computers with the space shuttle application as end usage. The system level digital problems which have been encountered and documented are surveyed. From the large cross section of tests, an optimum set is recommended that has a high probability of discovering documented system level digital problems within laboratory environments. Defined is a baseline hardware, software system which is required as a laboratory tool to test aerospace computers. Hardware and software baselines and additions necessary to interface the UTE to aerospace computers for test purposes are outlined.

Estrogen-withdrawal migraine. I. Duration of exposure required and attempted prophylaxis by premenstrual estrogen administration.

PubMed

Somerville, B W

1975-03-01

The minimum exposure to estrogen required to cause estrogen-withdrawal migraine has been studied by giving long-acting estradiol valerate to four women and short-acting estradiol benzoate to two women. It was found that several days of exposure to high estrogen levels were needed to cause migraine on estrogen withdrawal. Oral administration of estrogen supplements in the form of estradiol valerate or as conjugated equine estrogens during the premenstrual phase in four women did not significantly affect plasma levels of estradiol, nor was it effective in preventing menstrual migraine.

New Directions in Space Operations Services in Support of Interplanetary Exploration

NASA Technical Reports Server (NTRS)

Bradford, Robert N.

2005-01-01

To gain access to the necessary operational processes and data in support of NASA's Lunar/Mars Exploration Initiative, new services, adequate levels of computing cycles and access to myriad forms of data must be provided to onboard spacecraft and ground based personnel/systems (earth, lunar and Martian) to enable interplanetary exploration by humans. These systems, cycles and access to vast amounts of development, test and operational data will be required to provide a new level of services not currently available to existing spacecraft, on board crews and other operational personnel. Although current voice, video and data systems in support of current space based operations has been adequate, new highly reliable and autonomous processes and services will be necessary for future space exploration activities. These services will range from the more mundane voice in LEO to voice in interplanetary travel which because of the high latencies will require new voice processes and standards. New services, like component failure predictions based on data mining of significant quantities of data, located at disparate locations, will be required. 3D or holographic representation of onboard components, systems or family members will greatly improve maintenance, operations and service restoration not to mention crew morale. Current operational systems and standards, like the Internet Protocol, will not able to provide the level of service required end to end from an end point on the Martian surface like a scientific instrument to a researcher at a university. Ground operations whether earth, lunar or Martian and in flight operations to the moon and especially to Mars will require significant autonomy that will require access to highly reliable processing capabilities, data storage based on network storage technologies. Significant processing cycles will be needed onboard but could be borrowed from other locations either ground based or onboard other spacecraft. Reliability will be a key factor with onboard and distributed backup processing an absolutely necessary requirement. Current cluster processing/Grid technologies may provide the basis for providing these services. An overview of existing services, future services that will be required and the technologies and standards required to be developed will be presented. The purpose of this paper will be to initiate a technological roadmap, albeit at a high level, of current voice, video, data and network technologies and standards (which show promise for adaptation or evolution) to what technologies and standards need to be redefined, adjusted or areas where new ones require development. The roadmap should begin the differentiation between non manned and manned processes/services where applicable. The paper will be based in part on the activities of the CCSDS Monitor and Control working group which is beginning the process of standardization of the these processes. Another element of the paper will be based on an analysis of current technologies supporting space flight processes and services at JSC, MSFC, GSFC and to a lesser extent at KSC. Work being accomplished in areas such as Grid computing, data mining and network storage at ARC, IBM and the University of Alabama at Huntsville will be researched and analyzed.

High femoral artery bifurcation predicts contralateral high bifurcation: implications for complex percutaneous cardiovascular procedures requiring large caliber and/or dual access.

PubMed

Gupta, Vipul; Feng, Kent; Cheruvu, Pavan; Boyer, Nathan; Yeghiazarians, Yerem; Ports, Thomas A; Zimmet, Jeffrey; Shunk, Kendrick; Boyle, Andrew J

2014-09-01

Recent advances in technology have led to an increase in the use of bilateral femoral artery access and the requirement for large-bore access. Optimal access is in the common femoral artery (CFA), rather than higher (in the external iliac artery) or lower (in one of the branches of the CFA). However, there is a paucity of data in the literature about the relationship between bifurcation level of one CFA and the contralateral CFA. To define the prevalence of high bifurcation of the CFA and the relationship between bifurcation level on both sides, we performed a retrospective analysis of all patients with bilateral femoral angiography. From 4880 femoral angiograms performed at UCSF cardiac catheterization laboratory between 2005-2013, a total of 273 patients had bilateral femoral angiograms. The prevalence of low/normal, high, and very-high femoral bifurcations was 70%, 26%, and 4%, respectively, with no difference between sides. A high or very-high bifurcation significantly increased the likelihood of a high bifurcation on the contralateral side (odds ratio >3.0). Multivariable logistic regression analysis revealed age, gender, self-reported race, height, weight, and body mass index were not predictive of high or very-high bifurcations on either side. In conclusion, high femoral artery bifurcations are common and increase the likelihood of a high bifurcation of the contralateral femoral artery.

The Application of Orthophosphate to Reduce Elevated Copper Levels in a New Building with High DIC Water

EPA Science Inventory

Public water utilities in the United States are required to meet the 1991 Lead and Copper Rule action level of 1.3 mg/L for copper I drinking water. The effect of water chemistry on Cu(II) solubility has been studied, and drawing upon conclusions from this research , new copper ...

Grinding and classification of pine bark for use as plywood adhesive filler

Treesearch

Thomas L. Eberhardt; Karen G. Reed

2005-01-01

Prior efforts to incorporate bark or bark extracts into composites have met with only limited success because of poor performance relative to existing products and/or economic barriers stemming from high levels of processing. We are currently investigating applications for southern yellow pine (SYP) bark that require intermediate levels of processing, one being the use...

Restoring California black oak ecosystems to promote tribal values and wildlife

Treesearch

Jonathan W. Long; M. Kat Anderson; Lenya Quinn-Davidson; Ron W. Goode; Frank K. Lake; Carl N. Skinner

2016-01-01

This report synthesizes information to help promote the distinctive ecological and cultural benefits provided by California black oak. Production of abundant, high-quality acorns desired by Native Americans in California, as well as other valued services, requires the presence of mature, broad-crowned trees with low fuel levels and low pest levels. Although black oaks...

THE DETERMINATION OF MERCURY AND MULTIPLE METALS IN DIETARY MATRICES USING DIRECT INJECTION NEBULIZATION INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY (DIN-ICP/MS)

EPA Science Inventory

Mercury (Hg) is a Persistent Bioaccumulative Toxin. Currently, low-level mercury (Hg) and low-level multiple-metals analyses require separate methods. Due to the high costs of performing both types of analyses, research planners often have to choose one or the other. For examp...

Self-Directed Student Research through Analysis of Microarray Datasets: A Computer-Based Functional Genomics Practical Class for Masters-Level Students

ERIC Educational Resources Information Center

Grenville-Briggs, Laura J.; Stansfield, Ian

2011-01-01

This report describes a linked series of Masters-level computer practical workshops. They comprise an advanced functional genomics investigation, based upon analysis of a microarray dataset probing yeast DNA damage responses. The workshops require the students to analyse highly complex transcriptomics datasets, and were designed to stimulate…

Honors Teachers and Academic Identity: What to Look for When Recruiting Honors Faculty

ERIC Educational Resources Information Center

Dailey, Rocky

2016-01-01

To be a collegiate honors student implies a higher level of academic achievement than other students as well as the more challenging academic experience that comes with smaller class sizes. Collegiate honors teachers have a distinction of their own. Being an honors teacher implies a high level of teaching achievement, and it requires special…

A Scenario-Based Process for Requirements Development: Application to Mission Operations Systems

NASA Technical Reports Server (NTRS)

Bindschadler, Duane L.; Boyles, Carole A.

2008-01-01

The notion of using operational scenarios as part of requirements development during mission formulation (Phases A & B) is widely accepted as good system engineering practice. In the context of developing a Mission Operations System (MOS), there are numerous practical challenges to translating that notion into the cost-effective development of a useful set of requirements. These challenges can include such issues as a lack of Project-level focus on operations issues, insufficient or improper flowdown of requirements, flowdown of immature or poor-quality requirements from Project level, and MOS resource constraints (personnel expertise and/or dollars). System engineering theory must be translated into a practice that provides enough structure and standards to serve as guidance, but that retains sufficient flexibility to be tailored to the needs and constraints of a particular MOS or Project. We describe a detailed, scenario-based process for requirements development. Identifying a set of attributes for high quality requirements, we show how the portions of the process address many of those attributes. We also find that the basic process steps are robust, and can be effective even in challenging Project environments.

Strategy to Improve Naval Shipbuilding Industry Self-Reliance in Indonesia

DTIC Science & Technology

2017-12-01

investment in the defense industry sector. As the biggest archipelagic country in the world, Indonesia’s demand for maritime technology is high . It...the growth of the maritime industry around the country. However, the naval shipbuilding industry carries high risk and requires high capital for...the high threat level with the region, India and South Korea give more attention to national security by providing a higher budget for defense

5-Beam ADCP Deployment Strategy Considerations

NASA Astrophysics Data System (ADS)

Moore, T.; Savidge, D. K.; Gargett, A.

2016-02-01

With the increasing availability of 5 beam ADCPs and expanding opportunities for their deployment within both observatory and dedicated process study settings, refinements in deployment strategies are needed.Measuring vertical velocities directly with a vertically oriented acoustic beam requires that the instrument be stably mounted and leveled within fractions of a degree. Leveled shallow water deployments to date have utilized divers to jet pipes into the sand for stability, manually mount the instruments on the pipes, and level them. Leveling has been guided by the deployed instrument's pitch and roll output, available in real-time because of the observatory settings in which the deployments occurred. To expand the range of feasible deployments to deeper, perhaps non-real-time capable settings, alternatives to diver deployment and leveling must be considered. To determine stability requirements, mooring motion (heading, pitch and roll) has been sampled at 1Hz by gimballed ADCPs at a range of instrument deployment depths, and in shrouded and unshrouded cages. Conditions under which ADCP cages resting on the bottom experience significant shifts in tilt, roll or heading are assessed using co-located wind and wave measurements. The accuracy of estimating vertical velocities using all five beams relative to a well leveled vertical single beam is assessed from archived high frequency five beam data, to explore whether easing the leveling requirement is feasible.

The levels of perceptual processing and the neural correlates of increasing subjective visibility.

PubMed

Binder, Marek; Gociewicz, Krzysztof; Windey, Bert; Koculak, Marcin; Finc, Karolina; Nikadon, Jan; Derda, Monika; Cleeremans, Axel

2017-10-01

According to the levels-of-processing hypothesis, transitions from unconscious to conscious perception may depend on stimulus processing level, with more gradual changes for low-level stimuli and more dichotomous changes for high-level stimuli. In an event-related fMRI study we explored this hypothesis using a visual backward masking procedure. Task requirements manipulated level of processing. Participants reported the magnitude of the target digit in the high-level task, its color in the low-level task, and rated subjective visibility of stimuli using the Perceptual Awareness Scale. Intermediate stimulus visibility was reported more frequently in the low-level task, confirming prior behavioral results. Visible targets recruited insulo-fronto-parietal regions in both tasks. Task effects were observed in visual areas, with higher activity in the low-level task across all visibility levels. Thus, the influence of level of processing on conscious perception may be mediated by attentional modulation of activity in regions representing features of consciously experienced stimuli. Copyright © 2017 Elsevier Inc. All rights reserved.

High-performance radial AMTEC cell design for ultra-high-power solar AMTEC systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendricks, T.J.; Huang, C.

1999-07-01

Alkali Metal Thermal to Electric Conversion (AMTEC) technology is rapidly maturing for potential application in ultra-high-power solar AMTEC systems required by potential future US Air Force (USAF) spacecraft missions in medium-earth and geosynchronous orbits (MEO and GEO). Solar thermal AMTEC power systems potentially have several important advantages over current solar photovoltaic power systems in ultra-high-power spacecraft applications for USAF MEO and GEO missions. This work presents key aspects of radial AMTEC cell design to achieve high cell performance in solar AMTEC systems delivering larger than 50 kW(e) to support high power USAF missions. These missions typically require AMTEC cell conversionmore » efficiency larger than 25%. A sophisticated design parameter methodology is described and demonstrated which establishes optimum design parameters in any radial cell design to satisfy high-power mission requirements. Specific relationships, which are distinct functions of cell temperatures and pressures, define critical dependencies between key cell design parameters, particularly the impact of parasitic thermal losses on Beta Alumina Solid Electrolyte (BASE) area requirements, voltage, number of BASE tubes, and system power production for both maximum power-per-BASE-area and optimum efficiency conditions. Finally, some high-level system tradeoffs are demonstrated using the design parameter methodology to establish high-power radial cell design requirements and philosophy. The discussion highlights how to incorporate this methodology with sophisticated SINDA/FLUINT AMTEC cell modeling capabilities to determine optimum radial AMTEC cell designs.« less

Working memory load can both improve and impair selective attention: evidence from the Navon paradigm.

PubMed

Ahmed, Lubna; de Fockert, Jan W

2012-10-01

Selective attention to relevant targets has been shown to depend on the availability of working memory (WM). Under conditions of high WM load, processing of irrelevant distractors is enhanced. Here we showed that this detrimental effect of WM load on selective attention efficiency is reversed when the task requires global- rather than local-level processing. Participants were asked to attend to either the local or the global level of a hierarchical Navon stimulus while keeping either a low or a high load in WM. In line with previous findings, during attention to the local level, distractors at the global level produced more interference under high than under low WM load. By contrast, loading WM had the opposite effect of improving selective attention during attention to the global level. The findings demonstrate that the impact of WM load on selective attention is not invariant, but rather is dependent on the level of the to-be-attended information.

Estimating the discharge for ordinary high water levels in Kansas.

DOT National Transportation Integrated Search

2014-09-01

The water resource design community in Kansas, including the Kansas Department of Transportation : (KDOT), is required to obtain appropriate permits for construction projects. Projects that involve stream : modification, including drainage structures...

High-Capacity Communications from Martian Distances Part 4: Assessment of Spacecraft Pointing Accuracy Capabilities Required For Large Ka-Band Reflector Antennas

NASA Technical Reports Server (NTRS)

Hodges, Richard E.; Sands, O. Scott; Huang, John; Bassily, Samir

2006-01-01

Improved surface accuracy for deployable reflectors has brought with it the possibility of Ka-band reflector antennas with extents on the order of 1000 wavelengths. Such antennas are being considered for high-rate data delivery from planetary distances. To maintain losses at reasonable levels requires a sufficiently capable Attitude Determination and Control System (ADCS) onboard the spacecraft. This paper provides an assessment of currently available ADCS strategies and performance levels. In addition to other issues, specific factors considered include: (1) use of "beaconless" or open loop tracking versus use of a beacon on the Earth side of the link, and (2) selection of fine pointing strategy (body-fixed/spacecraft pointing, reflector pointing or various forms of electronic beam steering). Capabilities of recent spacecraft are discussed.

Vaccination coverage among children in kindergarten - United States, 2013-14 school year.

PubMed

Seither, Ranee; Masalovich, Svetlana; Knighton, Cynthia L; Mellerson, Jenelle; Singleton, James A; Greby, Stacie M

2014-10-17

State and local vaccination requirements for school entry are implemented to maintain high vaccination coverage and protect schoolchildren from vaccine-preventable diseases. Each year, to assess state and national vaccination coverage and exemption levels among kindergartners, CDC analyzes school vaccination data collected by federally funded state, local, and territorial immunization programs. This report describes vaccination coverage in 49 states and the District of Columbia (DC) and vaccination exemption rates in 46 states and DC for children enrolled in kindergarten during the 2013-14 school year. Median vaccination coverage was 94.7% for 2 doses of measles, mumps, and rubella (MMR) vaccine; 95.0% for varying local requirements for diphtheria, tetanus toxoid, and acellular pertussis (DTaP) vaccine; and 93.3% for 2 doses of varicella vaccine among those states with a 2-dose requirement. The median total exemption rate was 1.8%. High exemption levels and suboptimal vaccination coverage leave children vulnerable to vaccine-preventable diseases. Although vaccination coverage among kindergartners for the majority of reporting states was at or near the 95% national Healthy People 2020 targets for 4 doses of DTaP, 2 doses of MMR, and 2 doses of varicella vaccine, low vaccination coverage and high exemption levels can cluster within communities. Immunization programs might have access to school vaccination coverage and exemption rates at a local level for counties, school districts, or schools that can identify areas where children are more vulnerable to vaccine-preventable diseases. Health promotion efforts in these local areas can be used to help parents understand the risks for vaccine-preventable diseases and the protection that vaccinations provide to their children.

Welcoming a New Generation to College: The Millennial Students

ERIC Educational Resources Information Center

Elam, Carol; Stratton, Terry; Gibson, Denise D.

2007-01-01

High on any required reading list for college-level student affairs officers and high school counselors is "Millennials Rising: The Next Great Generation" by Neil Howe and William Strauss (2000). Experts on generational change in the United States, the authors contend that the current generation of college-age and pre-college-age…

Bridging Physics to Electronics--An Outreach Effort

ERIC Educational Resources Information Center

Tan, Kok-Kiong; Tang, Kok-Zuea; Ng, Vivian; Tay, Arthur; Yen, Shih-Cheng; Lee, Tong-Heng

2010-01-01

Physics has been an important part of the science curriculum in high schools. Without the appropriate high school physics background, it is difficult for a student subsequently to pursue an electronics engineering program at the university level since a good understanding of many concepts in physics is required to comprehend the material covered…

[East Syracuse-Minoa Schools Environmental Education Materials, High School Package.

ERIC Educational Resources Information Center

East Syracuse - Minoa Central Schools, East Syracuse, NY.

This series of four environmental education units is designed for use at the high school level. The first unit, an advanced science and independent study, includes such topics as student requirements, advisor responsibilities, evaluation forms, research report format, a guide to Syracuse University libraries, and research ideas. The second unit,…

Successful Students in an Open and Distance Learning System

ERIC Educational Resources Information Center

Puspitasari, Kristanti Ambar; Oetoyo, Boedhi

2018-01-01

Learning in a higher education institution that applies an open and distance learning system requires the students to study as independent learners. This research is a survey research with the purpose of exploring the characteristics, habits and learning motivation of high-achiever students or those who obtained a high level of Grade Point Average…

A Challenging High School Education for All

ERIC Educational Resources Information Center

US Department of Education, 2006

2006-01-01

High school is the training ground for college and work. Today, most good jobs require a college education. The way for children to get ready for college is to take challenging courses. The level of math, science and foreign language education students receive will be important for American global competitiveness and national security. In…

78 FR 53646 - Shared Responsibility Payment for Not Maintaining Minimum Essential Coverage

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... disabled child who requires an institutional level of care (such as that provided in a nursing facility... because their income is too high. Children eligible for Medicaid under this option are entitled to the... eligibility to individuals with high medical expenses who would otherwise be eligible for Medicaid but for...

Teaching Front Handsprings from a Developmental Approach

ERIC Educational Resources Information Center

Stork, Steve

2006-01-01

The front handspring is an important gymnastics skill that serves as a transition from beginner-level rolling and static balances to more advanced tumbling. It is, therefore, a skill highly desired by beginners. Early learning requires a great deal of effort during which students experience many failed attempts. Unless they are highly motivated,…

The Meaning of Work: A High School Perspective.

ERIC Educational Resources Information Center

Robinson, Jacquelyn P.; Shannon, David

Because of a recognition that the requirements of employees and the work values held by young people have been changing, a study was conducted to determine the meaning associated with work among high school consumer and homemaking home economics students. The effect of two independent variables, grade level and grade point average (GPA), was…

United States planetary rover status: 1989

NASA Technical Reports Server (NTRS)

Pivirotto, Donna L. S.; Dias, William C.

1990-01-01

A spectrum of concepts for planetary rovers and rover missions, is covered. Rovers studied range from tiny micro rovers to large and highly automated vehicles capable of traveling hundreds of kilometers and performing complex tasks. Rover concepts are addressed both for the Moon and Mars, including a Lunar/Mars common rover capable of supporting either program with relatively small modifications. Mission requirements considered include both Science and Human Exploration. Studies include a range of autonomy in rovers, from interactive teleoperated systems to those requiring and onboard System Executive making very high level decisions. Both high and low technology rover options are addressed. Subsystems are described for a representative selection of these rovers, including: Mobility, Sample Acquisition, Science, Vehicle Control, Thermal Control, Local Navigation, Computation and Communications. System descriptions of rover concepts include diagrams, technology levels, system characteristics, and performance measurement in terms of distance covered, samples collected, and area surveyed for specific representative missions. Rover development schedules and costs are addressed for Lunar and Mars exploration initiatives.

Design of a fast computer-based partial discharge diagnostic system

NASA Technical Reports Server (NTRS)

Oliva, Jose R.; Karady, G. G.; Domitz, Stan

1991-01-01

Partial discharges cause progressive deterioration of insulating materials working in high voltage conditions and may lead ultimately to insulator failure. Experimental findings indicate that deterioration increases with the number of discharges and is consequently proportional to the magnitude and frequency of the applied voltage. In order to obtain a better understanding of the mechanisms of deterioration produced by partial discharges, instrumentation capable of individual pulse resolution is required. A new computer-based partial discharge detection system was designed and constructed to conduct long duration tests on sample capacitors. This system is capable of recording large number of pulses without dead time and producing valuable information related to amplitude, polarity, and charge content of the discharges. The operation of the system is automatic and no human supervision is required during the testing stage. Ceramic capacitors were tested at high voltage in long duration tests. The obtained results indicated that the charge content of partial discharges shift towards high levels of charge as the level of deterioration in the capacitor increases.

Development of the One Centimeter Accuracy Geoid Model of Latvia for GNSS Measurements

NASA Astrophysics Data System (ADS)

Balodis, J.; Silabriedis, G.; Haritonova, D.; Kaļinka, M.; Janpaule, I.; Morozova, K.; Jumāre, I.; Mitrofanovs, I.; Zvirgzds, J.; Kaminskis, J.; Liepiņš, I.

2015-11-01

There is an urgent necessity for a highly accurate and reliable geoid model to enable prompt determination of normal height with the use of GNSS coordinate determination due to the high precision requirements in geodesy, building and high precision road construction development. Additionally, the Latvian height system is in the process of transition from BAS- 77 (Baltic Height System) to EVRS2007 system. The accuracy of the geoid model must approach the precision of about ∼1 cm looking forward to the Baltic Rail and other big projects. The use of all the available and verified data sources is planned, including the use of enlarged set of GNSS/levelling data, gravimetric measurement data and, additionally, the vertical deflection measurements over the territory of Latvia. The work is going ahead stepwise. Just the issue of GNSS reference network stability is discussed. In order to achieve the ∼1 cm precision geoid, it is required to have a homogeneous high precision GNSS network as a basis for ellipsoidal height determination for GNSS/levelling points. Both the LatPos and EUPOS® - Riga network have been examined in this article.

Positive Disintegration as a Process of Symmetry Breaking.

PubMed

Laycraft, Krystyna

2017-04-01

This article presents an analysis of the positive disintegration as a process of symmetry breaking. Symmetry breaking plays a major role in self-organized patterns formation and correlates directly to increasing complexity and function specialization. According to Dabrowski, a creator of the Theory of Positive Disintegration, the change from lower to higher levels of human development requires a major restructuring of an individual's psychological makeup. Each level of human development is a relatively stable and coherent configuration of emotional-cognitive patterns called developmental dynamisms. Their main function is to restructure a mental structure by breaking the symmetry of a low level and bringing differentiation and then integration to higher levels. The positive disintegration is then the process of transitions from a lower level of high symmetry and low complexity to higher levels of low symmetry and high complexity of mental structure.

Assessment of Service Life for Regenerative ECLSS Resin Beds

NASA Technical Reports Server (NTRS)

Cloud, Dale L.; Keilich, Maria C.; Polis, Peter C.; Yanczura, Stephen J.

2013-01-01

The International Space Station (ISS) Water Processor Assembly (WPA) and Oxygen Generation Assembly (OGA) manage and process water at various levels of cleanliness for multiple purposes. The effluent of theWPA and the influent of the OGA require water at very high levels of purity. The bulk of the water purification that occurs in both systems is performed by consumable activated carbon and ion exchange resin beds. Replacement beds must be available on orbit in order to continue the ISS critical processes of water purification and oxygen generation. Various hurdles exist in order to ensure viable spare resin beds. These include the characteristics of resin beds such as: storage environment, shelf life requirements, microbial growth, and variations in the levels and species of contaminants the beds are required to remove. Careful consideration has been given to match water models, bed capacities and spares traffic models to ensure that spares are always viable. The results of these studies and considerations, in particular, how shelf life requirements affect resin bed life management, are documented in this paper.

Buddy Tag CONOPS and Requirements.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brotz, Jay Kristoffer; Deland, Sharon M.

2015-12-01

This document defines the concept of operations (CONOPS) and the requirements for the Buddy Tag, which is conceived and designed in collaboration between Sandia National Laboratories and Princeton University under the Department of State Key VerificationAssets Fund. The CONOPS describe how the tags are used to support verification of treaty limitations and is only defined to the extent necessary to support a tag design. The requirements define the necessary functions and desired non-functional features of the Buddy Tag at a high level

Flight program language requirements. Volume 3: Appendices

NASA Technical Reports Server (NTRS)

1972-01-01

Government-sponsored study and development efforts were directed toward design and implementation of high level programming languages suitable for future aerospace applications. The study centered around an evaluation of the four most pertinent existing aerospace languages. Evaluation criteria were established, and selected kernels from the current Saturn 5 and Skylab flight programs were used as benchmark problems for sample coding. An independent review of the language specifications incorporated anticipated future programming requirements into the evaluation. A set of language requirements was synthesized from these activities.

Current science requirements and planned implementation for the WFIRST-CGI Integral Field Spectrograph (IFS)

NASA Astrophysics Data System (ADS)

Mandell, Avi M.; Groff, Tyler D.; Gong, Qian; Rizzo, Maxime J.; Lupu, Roxana; Zimmerman, Neil T.; Saxena, Prabal; McElwain, Michael W.

2017-09-01

One of the key science goals of the Coronograph Instrument (CGI) on the WFIRST mission is to spectrally characterize the atmospheres of planets around other stars at extremely high contrast levels. To achieve this goal, the CGI instrument will include a integral field spectrograph (IFS) as one of the two science cameras. We present the current science requirements that pertain to the IFS design, describe how our design implementation flows from these requirements, and outline our current instrument design.

Current Science Requirements and Planned Implementation for the WFIRST-CGI Integral Field Spectrograph (IFS)

NASA Technical Reports Server (NTRS)

Mandell, Avi M.; Groff, Tyler D.; Gong, Qian; Rizzo, Maxime J.; Lupu, Roxana; Zimmerman, Neil T.; Saxena, Prabal; McElwain, Michael W.

2017-01-01

One of the key science goals of the Coronograph Instrument (CGI) on the WFIRST mission is to spectrally characterize the atmospheres of planets around other stars at extremely high contrast levels. To achieve this goal, the CGI Instrument will include a integral field spectrograph (IFS) as one of the two science cameras. We present the current science requirements that pertain to the IFS design, describe how our design implementation flows from these requirements, and outline our current instrument design.

The NASA GSFC MEMS Colloidal Thruster

NASA Technical Reports Server (NTRS)

Cardiff, Eric H.; Jamieson, Brian G.; Norgaard, Peter C.; Chepko, Ariane B.

2004-01-01

A number of upcoming missions require different thrust levels on the same spacecraft. A highly scaleable and efficient propulsion system would allow substantial mass savings. One type of thruster that can throttle from high to low thrust while maintaining a high specific impulse is a Micro-Electro-Mechanical System (MEMS) colloidal thruster. The NASA GSFC MEMS colloidal thruster has solved the problem of electrical breakdown to permit the integration of the electrode on top of the emitter by a novel MEMS fabrication technique. Devices have been successfully fabricated and the insulation properties have been tested to show they can support the required electric field. A computational finite element model was created and used to verify the voltage required to successfully operate the thruster. An experimental setup has been prepared to test the devices with both optical and Time-Of-Flight diagnostics.

Measurement technology of RF interference current in high current system

NASA Astrophysics Data System (ADS)

Zhao, Zhihua; Li, Jianxuan; Zhang, Xiangming; Zhang, Lei

2018-06-01

Current probe is a detection method commonly used in electromagnetic compatibility. With the development of power electronics technology, the power level of power conversion devices is constantly increasing, and the power current of the electric energy conversion device in the electromagnetic launch system can reach 10kA. Current probe conventionally used in EMC (electromagnetic compatibility) detection cannot meet the test requirements on high current system due to the magnetic saturation problem. The conventional high current sensor is also not suitable for the RF (Radio Frequency) interference current measurement in high current power device due to the high noise level in the output of active amplifier. In this paper, a passive flexible current probe based on Rogowski coil and matching resistance is proposed that can withstand high current and has low noise level, to solve the measurement problems of interference current in high current power converter. And both differential mode and common mode current detection can be easily carried out with the proposed probe because of the probe's flexible structure.

Packaging Technologies for 500C SiC Electronics and Sensors

NASA Technical Reports Server (NTRS)

Chen, Liang-Yu

2013-01-01

Various SiC electronics and sensors are currently under development for applications in 500C high temperature environments such as hot sections of aerospace engines and the surface of Venus. In order to conduct long-term test and eventually commercialize these SiC devices, compatible packaging technologies for the SiC electronics and sensors are required. This presentation reviews packaging technologies developed for 500C SiC electronics and sensors to address both component and subsystem level packaging needs for high temperature environments. The packaging system for high temperature SiC electronics includes ceramic chip-level packages, ceramic printed circuit boards (PCBs), and edge-connectors. High temperature durable die-attach and precious metal wire-bonding are used in the chip-level packaging process. A high temperature sensor package is specifically designed to address high temperature micro-fabricated capacitive pressure sensors for high differential pressure environments. This presentation describes development of these electronics and sensor packaging technologies, including some testing results of SiC electronics and capacitive pressure sensors using these packaging technologies.

Readability of Online Patient Education Materials Related to IR.

PubMed

McEnteggart, Gregory E; Naeem, Muhammad; Skierkowski, Dorothy; Baird, Grayson L; Ahn, Sun H; Soares, Gregory

2015-08-01

To assess the readability of online patient education materials (OPEM) related to common diseases treated by and procedures performed by interventional radiology (IR). The following websites were chosen based on their average Google search return for each IR OPEM content area examined in this study: Society of Interventional Radiology (SIR), Cardiovascular and Interventional Radiological Society of Europe (CIRSE), National Library of Medicine, RadiologyInfo, Mayo Clinic, WebMD, and Wikipedia. IR OPEM content area was assessed for the following: peripheral arterial disease, central venous catheter, varicocele, uterine artery embolization, vertebroplasty, transjugular intrahepatic portosystemic shunt, and deep vein thrombosis. The following algorithms were used to estimate and compare readability levels: Flesch-Kincaid Grade Formula, Flesch Reading Ease Score, Gunning Frequency of Gobbledygook, Simple Measure of Gobbledygook, and Coleman-Liau Index. Data were analyzed using general mixed modeling. On average, online sources that required beyond high school grade-level readability were Wikipedia (15.0), SIR (14.2), and RadiologyInfo (12.4); sources that required high school grade-level readability were CIRSE (11.3), Mayo Clinic (11.0), WebMD (10.6), and National Library of Medicine (9.0). On average, OPEM on uterine artery embolization, vertebroplasty, varicocele, and peripheral arterial disease required the highest level of readability (12.5, 12.3, 12.3, and 12.2, respectively). The IR OPEM assessed in this study were written above the recommended sixth-grade reading level and the health literacy level of the average American adult. Many patients in the general public may not have the ability to read and understand health information in IR OPEM. Copyright © 2015 SIR. Published by Elsevier Inc. All rights reserved.

Oxygen-enriched air for MHD power plants

NASA Technical Reports Server (NTRS)

Ebeling, R. W., Jr.; Cutting, J. C.; Burkhart, J. A.

1979-01-01

Cryogenic air-separation process cycle variations and compression schemes are examined. They are designed to minimize net system power required to supply pressurized, oxygen-enriched air to the combustor of an MHD power plant with a coal input of 2000 MWt. Power requirements and capital costs for oxygen production and enriched air compression for enrichment levels from 13 to 50% are determined. The results are presented as curves from which total compression power requirements can be estimated for any desired enrichment level at any delivery pressure. It is found that oxygen enrichment and recuperative heating of MHD combustor air to 1400 F yields near-term power plant efficiencies in excess of 45%. A minimum power compression system requires 167 MW to supply 330 lb of oxygen per second and costs roughly 100 million dollars. Preliminary studies show MHD/steam power plants to be competitive with plants using high-temperature air preheaters burning gas.

Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion.

PubMed

Zick, Michael; Stroupe, Christopher; Orr, Amy; Douville, Deborah; Wickner, William T

2014-01-01

Like other intracellular fusion events, the homotypic fusion of yeast vacuoles requires a Rab GTPase, a large Rab effector complex, SNARE proteins which can form a 4-helical bundle, and the SNARE disassembly chaperones Sec17p and Sec18p. In addition to these proteins, specific vacuole lipids are required for efficient fusion in vivo and with the purified organelle. Reconstitution of vacuole fusion with all purified components reveals that high SNARE levels can mask the requirement for a complex mixture of vacuole lipids. At lower, more physiological SNARE levels, neutral lipids with small headgroups that tend to form non-bilayer structures (phosphatidylethanolamine, diacylglycerol, and ergosterol) are essential. Membranes without these three lipids can dock and complete trans-SNARE pairing but cannot rearrange their lipids for fusion. DOI: http://dx.doi.org/10.7554/eLife.01879.001.

Correlation of Level of Trauma Activation With Emergency Department Intervention.

PubMed

Cooper, Michael C; Srivastava, Geetanjali

2018-06-01

In-hospital trauma team activation criteria are formulated to identify severely injured patients requiring specialized multidisciplinary care. Efficacy of trauma activation (TA) criteria is commonly measured by emergency department (ED) disposition, injury severity score, and mortality. Necessity of critical ED interventions is another measure that has been proposed to evaluate the appropriateness of TA criteria. Two-year retrospective cohort study of 1715 patients from our trauma registry at a Level 1 pediatric trauma center. We abstracted data on acute interventions, level and criterion of TA, ED disposition, and mortality. We report odds ratio (OR) with 95% confidence intervals (CIs), positive predictive value, and frequency of acute interventions. Trauma activation was initiated for 947 (55%) of the 1715 patients. There were 426 ED interventions performed on 235 patients (14%); 67.8% were in level 1 activations; 17.6% in level 2, and 14.6% in level 3. Highest-level activations were highly associated with need for ED interventions (OR, 16.1; 95% CI, 11.5-22.4). The ORs for requiring an ED intervention were low for lower level activations (OR, 0.4; 95% CI, 0.3-0.5), trauma service consults (OR, 0.3; 95% CI, 0.2-0.4), and certain mechanism-based criteria. The ORs for ED intervention for isolated motor vehicle collision (0.2; 95% CI, 0.1-0.7), isolated all-terrain vehicle rollover (0.4; 95% CI, 0.1-1.7), and suspected spinal cord injury (0.5; 95% CI, 0.1-3.7) were significantly lower than 1. Highest-level activation criteria correlate with high utilization of ED resources and interventions. Lower level activation criteria and trauma service consult criteria are not highly correlated with need for ED interventions. Downgrading isolated motor vehicle collision and all-terrain vehicle rollovers and suspected spinal cord injury to lower level activations could decrease the overtriage rate, and adding age-specific bradycardia as a physiologic criterion could improve our undertriage rate.

Up gradation of LHCD system for rf power level up to 2MW for SST1

NASA Astrophysics Data System (ADS)

Sharma, P. K.; Ambulkar, K. K.; Parmar, P. R.; Virani, C. G.; Thakur, A. L.; Kulkarni, S. V.; Lhcd Group

2010-02-01

To operate superconducting steadystate tokamak (SST1) for 1000 seconds, lower hybrid current drive (LHCD) system has been designed at a frequency of 3.7 GHz., which would couple 1.0 MW CW of microwave power to the shaped plasma. The system consists of various rf passive components and transmission line, employing which the rf power from the source is transported to the antenna. During calibration of transmission line, it was observed that the losses in the transmission line is substantial and eventually would lead to less coupled power to the plasma. Further it is anticipated that more LH power would be required for advanced operation of SST1 machine. Thus it is decided to upgrade the existing LHCD system to 2 MW CW power level. The proposed up gradation would demand several infra structural changes and needs to be addressed. Due to lack of space, we have proposed a scheme in which additional two klystrons, along with existing two klystrons would be accommodated in the existing space. The low rf power requirements have also been increased to cater the new needs. Accordingly additional cooling requirements have been proposed to accommodate the two new klystrons. The DAC and auxiliary power supplies have been also designed. The new up graded LHCD system would address several key technological issues. Firstly it would establish the operation of four klystrons at rated power in parallel employing single RHVPS (80kV, 70A). Secondly it would establish the operation of two high power klystrons operation at rated power when their collectors are cooled in series. In this paper we would present the various requirements for up-gradation of LHCD system to 2MW. The main requirements like high power rf source, along with modified support structure, low power rf systems to drive the high power rf source, auxiliary power supplies required for high power rf source, DAC system improvement, cooling improvements, etc. would be discussed.

Chronic High Fructose Intake Reduces Serum 1,25 (OH)2D3 Levels in Calcium-Sufficient Rodents

PubMed Central

Douard, Veronique; Patel, Chirag; Lee, Jacklyn; Tharabenjasin, Phuntila; Williams, Edek; Fritton, J. Christopher; Sabbagh, Yves; Ferraris, Ronaldo P.

2014-01-01

Excessive fructose consumption inhibits adaptive increases in intestinal Ca2+ transport in lactating and weanling rats with increased Ca2+ requirements by preventing the increase in serum levels of 1,25(OH)2D3. Here we tested the hypothesis that chronic fructose intake decreases 1,25(OH)2D3 levels independent of increases in Ca2+ requirements. Adult mice fed for five wk a high glucose-low Ca2+ diet displayed expected compensatory increases in intestinal and renal Ca2+ transporter expression and activity, in renal CYP27B1 (coding for 1α-hydroxylase) expression as well as in serum 1,25(OH)2D3 levels, compared with mice fed isocaloric glucose- or fructose-normal Ca2+ diets. Replacing glucose with fructose prevented these increases in Ca2+ transporter, CYP27B1, and 1,25(OH)2D3 levels induced by a low Ca2+ diet. In adult mice fed for three mo a normal Ca2+ diet, renal expression of CYP27B1 and of CYP24A1 (24-hydroxylase) decreased and increased, respectively, when the carbohydrate source was fructose instead of glucose or starch. Intestinal and renal Ca2+ transporter activity and expression did not vary with dietary carbohydrate. To determine the time course of fructose effects, a high fructose or glucose diet with normal Ca2+ levels was fed to adult rats for three mo. Serum levels of 1,25(OH)2D3 decreased and of FGF23 increased significantly over time. Renal expression of CYP27B1 and serum levels of 1,25(OH)2D3 still decreased in fructose- compared to those in glucose-fed rats after three mo. Serum parathyroid hormone, Ca2+ and phosphate levels were normal and independent of dietary sugar as well as time of feeding. Thus, chronically high fructose intakes can decrease serum levels of 1,25(OH)2D3 in adult rodents experiencing no Ca2+ stress and fed sufficient levels of dietary Ca2+. This finding is highly significant because fructose constitutes a substantial portion of the average diet of Americans already deficient in vitamin D. PMID:24718641

A preliminary design for the GMT-Consortium Large Earth Finder (G-CLEF)

NASA Astrophysics Data System (ADS)

Szentgyorgyi, Andrew; Barnes, Stuart; Bean, Jacob; Bigelow, Bruce; Bouchez, Antonin; Chun, Moo-Young; Crane, Jeffrey D.; Epps, Harland; Evans, Ian; Evans, Janet; Frebel, Anna; Furesz, Gabor; Glenday, Alex; Guzman, Dani; Hare, Tyson; Jang, Bi-Ho; Jang, Jeong-Gyun; Jeong, Ueejong; Jordan, Andres; Kim, Kang-Min; Kim, Jihun; Li, Chih-Hao; Lopez-Morales, Mercedes; McCracken, Kenneth; McLeod, Brian; Mueller, Mark; Nah, Jakyung; Norton, Timothy; Oh, Heeyoung; Oh, Jae Sok; Ordway, Mark; Park, Byeong-Gon; Park, Chan; Park, Sung-Joon; Phillips, David; Plummer, David; Podgorski, William; Rodler, Florian; Seifahrt, Andreas; Tak, Kyung-Mo; Uomoto, Alan; Van Dam, Marcos A.; Walsworth, Ronald; Yu, Young Sam; Yuk, In-Soo

2014-08-01

The GMT-Consortium Large Earth Finder (G-CLEF) is an optical-band echelle spectrograph that has been selected as the first light instrument for the Giant Magellan Telescope (GMT). G-CLEF is a general-purpose, high dispersion spectrograph that is fiber fed and capable of extremely precise radial velocity measurements. The G-CLEF Concept Design (CoD) was selected in Spring 2013. Since then, G-CLEF has undergone science requirements and instrument requirements reviews and will be the subject of a preliminary design review (PDR) in March 2015. Since CoD review (CoDR), the overall G-CLEF design has evolved significantly as we have optimized the constituent designs of the major subsystems, i.e. the fiber system, the telescope interface, the calibration system and the spectrograph itself. These modifications have been made to enhance G-CLEF's capability to address frontier science problems, as well as to respond to the evolution of the GMT itself and developments in the technical landscape. G-CLEF has been designed by applying rigorous systems engineering methodology to flow Level 1 Scientific Objectives to Level 2 Observational Requirements and thence to Level 3 and Level 4. The rigorous systems approach applied to G-CLEF establishes a well defined science requirements framework for the engineering design. By adopting this formalism, we may flexibly update and analyze the capability of G-CLEF to respond to new scientific discoveries as we move toward first light. G-CLEF will exploit numerous technological advances and features of the GMT itself to deliver an efficient, high performance instrument, e.g. exploiting the adaptive optics secondary system to increase both throughput and radial velocity measurement precision.

A cloud-based home health care information sharing system to connect patients with home healthcare staff -A case report of a study in a mountainous region.

PubMed

Nomoto, Shinichi; Utsumi, Momoe; Sasayama, Satoshi; Dekigai, Hiroshi

2017-01-01

We have developed a cloud system, the e-Renraku Notebook (e-RN) for sharing of home care information based on the concept of "patient-centricity". In order to assess the likelihood that our system will enhance the communication and sharing of information between home healthcare staff members and home-care patients, we selected patients who were residing in mountainous regions for inclusion in our study. We herein report the findings.Eighteen staff members from 7 medical facilities and 9 patients participated in the present study.The e-RN was developed for two reasons: to allow patients to independently report their health status and to have staff members view and respond to the information received. The patients and staff members were given iPads with the pre-installed applications and the information being exchanged was reviewed over a 54-day period.Information was mainly input by the patients (61.6%), followed by the nurses who performed home visits (19.9%). The amount of information input by patients requiring high-level nursing care and their corresponding staff member was significantly greater than that input by patients who required low-level of nursing care.This patient-centric system in which patients can independently report and share information with a member of the healthcare staff provides a sense of security. It also allows staff members to understand the patient's health status before making a home visit, thereby giving them a sense of security and confidence. It was also noteworthy that elderly patients requiring high-level nursing care and their staff counterpart input information in the system significantly more frequently than patients who required low-level care.

Development and Validation of High Precision Thermal, Mechanical, and Optical Models for the Space Interferometry Mission

NASA Technical Reports Server (NTRS)

Lindensmith, Chris A.; Briggs, H. Clark; Beregovski, Yuri; Feria, V. Alfonso; Goullioud, Renaud; Gursel, Yekta; Hahn, Inseob; Kinsella, Gary; Orzewalla, Matthew; Phillips, Charles

2006-01-01

SIM Planetquest (SIM) is a large optical interferometer for making microarcsecond measurements of the positions of stars, and to detect Earth-sized planets around nearby stars. To achieve this precision, SIM requires stability of optical components to tens of picometers per hour. The combination of SIM s large size (9 meter baseline) and the high stability requirement makes it difficult and costly to measure all aspects of system performance on the ground. To reduce risks, costs and to allow for a design with fewer intermediate testing stages, the SIM project is developing an integrated thermal, mechanical and optical modeling process that will allow predictions of the system performance to be made at the required high precision. This modeling process uses commercial, off-the-shelf tools and has been validated against experimental results at the precision of the SIM performance requirements. This paper presents the description of the model development, some of the models, and their validation in the Thermo-Opto-Mechanical (TOM3) testbed which includes full scale brassboard optical components and the metrology to test them at the SIM performance requirement levels.

Chronic alcohol binging injures the liver and other organs by reducing NAD⁺ levels required for sirtuin's deacetylase activity.

PubMed

French, Samuel W

2016-04-01

NAD(+) levels are markedly reduced when blood alcohol levels are high during binge drinking. This causes liver injury to occur because the enzymes that require NAD(+) as a cofactor such as the sirtuin de-acetylases cannot de-acetylate acetylated proteins such as acetylated histones. This prevents the epigenetic changes that regulate metabolic processes and which prevent organ injury such as fatty liver in response to alcohol abuse. Hyper acetylation of numerous regulatory proteins develops. Systemic multi-organ injury occurs when NAD(+) is reduced. For instance the Circadian clock is altered if NAD(+) is not available. Cell cycle arrest occurs due to up regulation of cell cycle inhibitors leading to DNA damage, mutations, apoptosis and tumorigenesis. NAD(+) is linked to aging in the regulation of telomere stability. NAD(+) is required for mitochondrial renewal. Alcohol dehydrogenase is present in every visceral organ in the body so that there is a systemic reduction of NAD(+) levels in all of these organs during binge drinking. Copyright © 2016. Published by Elsevier Inc.

Protein requirements for Blue-fronted Amazon (Amazona aestiva) growth.

PubMed

Carciofi, A C; Sanfilippo, L F; de-Oliveira, L D; do Amaral, P P; Prada, F

2008-06-01

The objective of this study was to evaluate the protein requirements for hand-rearing Blue-fronted Amazon parrots (Amazona aestiva). Forty hatchlings were fed semi-purified diets containing one of four (as-fed basis) protein levels: 13%, 18%, 23% and 28%. The experiment was carried out in a randomized block design with the initial weight of the nestling as the blocking factor and 10 parrots per protein level. Regression analysis was used to determine relationships between protein level and biometric measurements. The data indicated that 13% crude protein supported nestling growth with 18% being the minimum tested level required for maximum development. The optimal protein concentration for maximum weight gain was 24.4% (p = 0.08; r(2) = 0.25), tail length 23.7% (p = 0.09; r(2) = 0.19), wing length 23.0% (p = 0.07; r(2) = 0.17), tarsus length 21.3% (p = 0.06; r(2) = 0.10) and tarsus width 21.4% (p = 0.07; r(2) = 0.09). Tarsus measurements were larger in males (p < 0.05), indicating that sex must be considered when studying developing psittacines. These results were obtained using a highly digestible protein and a diet with moderate metabolizable energy levels.

Estimating the discharge for ordinary high water levels in Kansas : [technical summary].

DOT National Transportation Integrated Search

2014-09-01

The water resource design community in Kansas, including the Kansas Department : of Transportation (KDOT), is required to obtain appropriate permits for construction : projects. Projects that involve stream modification, including drainage structures...

An Architecture for Autonomous Rovers on Future Planetary Missions

NASA Astrophysics Data System (ADS)

Ocon, J.; Avilés, M.; Graziano, M.

2018-04-01

This paper proposes an architecture for autonomous planetary rovers. This architecture combines a set of characteristics required in this type of system: high level of abstraction, reactive event-based activity execution, and automous navigation.

High level waste storage tanks 242-A evaporator S/RID phase II assessment report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biebesheimer, E.

This document, the Standards/Requirements Identification Document (S/RID) Phase 2 Assessment Report for the subject facility, represents the results of a Performance Assessment to determine whether procedures containing S/RID requirements are fully implemented by field personnel in the field. It contains a summary report and three attachments; an assessment schedule, performance objectives, and assessments for selected functional areas.

Effects of Requiring Students to Meet High Expectation Levels within an On-Line Homework Environment

ERIC Educational Resources Information Center

Weber, William J., Jr.

2010-01-01

On-line homework is becoming a larger part of mathematics classrooms each year. Thus, ways to maximize the effectiveness of on-line homework for both students and teachers must be investigated. This study sought to provide one possible answer to this aim, by requiring students to achieve at least 50% for any on-line homework assignment in order to…

Evaluation of a Game to Teach Requirements Collection and Analysis in Software Engineering at Tertiary Education Level

ERIC Educational Resources Information Center

Hainey, Thomas; Connolly, Thomas M.; Stansfield, Mark; Boyle, Elizabeth A.

2011-01-01

A highly important part of software engineering education is requirements collection and analysis which is one of the initial stages of the Database Application Lifecycle and arguably the most important stage of the Software Development Lifecycle. No other conceptual work is as difficult to rectify at a later stage or as damaging to the overall…

Simulation of the High Performance Time to Digital Converter for the ATLAS Muon Spectrometer trigger upgrade

NASA Astrophysics Data System (ADS)

Meng, X. T.; Levin, D. S.; Chapman, J. W.; Zhou, B.

2016-09-01

The ATLAS Muon Spectrometer endcap thin-Resistive Plate Chamber trigger project compliments the New Small Wheel endcap Phase-1 upgrade for higher luminosity LHC operation. These new trigger chambers, located in a high rate region of ATLAS, will improve overall trigger acceptance and reduce the fake muon trigger incidence. These chambers must generate a low level muon trigger to be delivered to a remote high level processor within a stringent latency requirement of 43 bunch crossings (1075 ns). To help meet this requirement the High Performance Time to Digital Converter (HPTDC), a multi-channel ASIC designed by CERN Microelectronics group, has been proposed for the digitization of the fast front end detector signals. This paper investigates the HPTDC performance in the context of the overall muon trigger latency, employing detailed behavioral Verilog simulations in which the latency in triggerless mode is measured for a range of configurations and under realistic hit rate conditions. The simulation results show that various HPTDC operational configurations, including leading edge and pair measurement modes can provide high efficiency (>98%) to capture and digitize hits within a time interval satisfying the Phase-1 latency tolerance.

High Current Density Cathodes for Future Vacuum Electronics Applications

DTIC Science & Technology

2008-05-30

Tube - device for generating high levels of RF power DARPA Defense Advanced Research Agency PBG Photonic band gap W- Band 75-111 GHz dB Decibels GHz...Extended interaction klystron 1. Introduction All RF vacuum electron sources require a high quality electron beam for efficient operation. Research on...with long life. Pres- ently, only thermionic dispenser cathodes are practical for high power RF sources. Typical thermi- onic cathodes consists of a

Integrated Requirements Analysis and Technology Roadmaps

NASA Technical Reports Server (NTRS)

1997-01-01

In fiscal year 1997, Strategic Insight performed analytical studies for NASA's Highly Reusable Space Transportation (HRST) program, creating program documents which illuminated technical requirements and critical research opportunities. Studies were performed to structure and confirm HRST's evolving technical requirements, building on Marshall's Phase 1 work, which defined HRST system concepts, analytical tools and high-level issues for assessment in Phase 2. Specifically, Strategic Insight: (1) Performed a requirements analysis to update HRST: An Advanced Concepts Study, Study Guidelines, Version 2.0 of January 22, 1996; only minor changes were recommended for the given parameters of interest to concept designers; (2) Conducted mini-workshops during HRST Working Group meetings on April 14-15, 1997 and July 22-24, 1997; and (3) Created structures for technology road maps of candidate HRST concepts, both subsystem and end-to-end concepts, emerging from the 13 cooperative agreement projects.

Confidence limits and sample size for determining nonhost status of fruits and vegetables to tephritid fruit flies as a quarantine measure.

PubMed

Follett, Peter A; Hennessey, Michael K

2007-04-01

Quarantine measures including treatments are applied to exported fruit and vegetable commodities to control regulatory fruit fly pests and to reduce the likelihood of their introduction into new areas. Nonhost status can be an effective measure used to achieve quarantine security. As with quarantine treatments, nonhost status can stand alone as a measure if there is high efficacy and statistical confidence. The numbers of insects or fruit tested during investigation of nonhost status will determine the level of statistical confidence. If the level of confidence of nonhost status is not high, then additional measures may be required to achieve quarantine security as part of a systems approach. Certain countries require that either 99.99 or 99.9968% mortality, as a measure of efficacy, at the 95% confidence level, be achieved by a quarantine treatment to meet quarantine security. This article outlines how the level of confidence in nonhost status can be quantified so that its equivalency to traditional quarantine treatments may be demonstrated. Incorporating sample size and confidence levels into host status testing protocols along with efficacy will lead to greater consistency by regulatory decision-makers in interpreting results and, therefore, to more technically sound decisions on host status.

The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo.

PubMed

MacAlpine, D M; Perlman, P S; Butow, R A

1998-06-09

Abf2p is a high mobility group (HMG) protein found in yeast mitochondria that is required for the maintenance of wild-type (rho+) mtDNA in cells grown on fermentable carbon sources, and for efficient recombination of mtDNA markers in crosses. Here, we show by two-dimensional gel electrophoresis that Abf2p promotes or stabilizes Holliday recombination junction intermediates in rho+ mtDNA in vivo but does not influence the high levels of recombination intermediates readily detected in the mtDNA of petite mutants (rho-). mtDNA recombination junctions are not observed in rho+ mtDNA of wild-type cells but are elevated to detectable levels in cells with a null allele of the MGT1 gene (Deltamgt1), which codes for a mitochondrial cruciform-cutting endonuclease. The level of recombination intermediates in rho+ mtDNA of Deltamgt1 cells is decreased about 10-fold if those cells contain a null allele of the ABF2 gene. Overproduction of Abf2p by >/= 10-fold in wild-type rho+ cells, which leads to mtDNA instability, results in a dramatic increase in mtDNA recombination intermediates. Specific mutations in the two Abf2p HMG boxes required for DNA binding diminishes these responses. We conclude that Abf2p functions in the recombination of rho+ mtDNA.

Efficient parallelization for AMR MHD multiphysics calculations; implementation in AstroBEAR

NASA Astrophysics Data System (ADS)

Carroll-Nellenback, Jonathan J.; Shroyer, Brandon; Frank, Adam; Ding, Chen

2013-03-01

Current adaptive mesh refinement (AMR) simulations require algorithms that are highly parallelized and manage memory efficiently. As compute engines grow larger, AMR simulations will require algorithms that achieve new levels of efficient parallelization and memory management. We have attempted to employ new techniques to achieve both of these goals. Patch or grid based AMR often employs ghost cells to decouple the hyperbolic advances of each grid on a given refinement level. This decoupling allows each grid to be advanced independently. In AstroBEAR we utilize this independence by threading the grid advances on each level with preference going to the finer level grids. This allows for global load balancing instead of level by level load balancing and allows for greater parallelization across both physical space and AMR level. Threading of level advances can also improve performance by interleaving communication with computation, especially in deep simulations with many levels of refinement. While we see improvements of up to 30% on deep simulations run on a few cores, the speedup is typically more modest (5-20%) for larger scale simulations. To improve memory management we have employed a distributed tree algorithm that requires processors to only store and communicate local sections of the AMR tree structure with neighboring processors. Using this distributed approach we are able to get reasonable scaling efficiency (>80%) out to 12288 cores and up to 8 levels of AMR - independent of the use of threading.

Nutritional Evaluation of Young Bulls on Tropical Pasture Receiving Supplements with Different Protein:Carbohydrate Ratios

PubMed Central

Valente, E. E. L.; Paulino, M. F.; Barros, L. V.; Almeida, D. M.; Martins, L. S.; Cabral, C. H. A.

2014-01-01

The objective of this work was to evaluate the nutritional parameters of young bulls supplemented with different ratios of protein: carbohydrate on tropical pastures from 4 until 18 months old. Fifty-five non-castrated beef calves (138.3±3.4 kg, 90 to 150 d of age) were used. The calves (young bulls) were subjected to a 430-d experimental period encompassing 4 seasons. The treatments were as follows: control, only mineral mixture; HPHC, high protein and high carbohydrate supplement; HPLC, high protein and low carbohydrate supplement; LPHC, low protein and high carbohydrate supplement; and LPLC, low protein and low carbohydrate supplement. The amount of supplement was adjusted every 28 d. Dry matter (DM) intake was higher in the dry-to-rainy transition and rainy seasons for all nutritional plans. Non-supplemented animals had lower intakes of DM and total digestible nutrients (TDN) than supplemented young bulls in all seasons. Although differences in DM intake were not observed between supplemented animals, the supplements with high carbohydrate (HPHC and LPHC) had lower forage intake during suckling (rainy-to-dry transition season) and in the rainy season. However, the HPHC treatment animals had higher intake and digestibility of neutral detergent fiber. It can be concluded that supplementation with high protein levels (supplying 50% of the crude protein requirement) provide the best nutritional parameters for grazing young bulls in most seasons, increasing intake and digestibility of diet, and these effects are more intense when associated with high carbohydrate levels level (supplying 30% TDN requirement). PMID:25178297

The Ethics of Environmental Concern: A Rationale and Prototype Materials for Environmental Education Within the Humanistic Tradition. Final Report, Volume 2.

ERIC Educational Resources Information Center

Allen, Rodney F.

As part of the series of student materials developed by the Environmental Education Project at Florida State University, this volume contains three instructional units on urban environment. Designed for upper-elementary and secondary students, the materials require only low-level reading abilities while insisting on high-level participation. The…

HigherEdUtah2020. 2014 Report

ERIC Educational Resources Information Center

Utah System of Higher Education, 2014

2014-01-01

Utah has set the goal of having 66% of its 25-35 age population with a post-secondary degree or certificate by 2020. To achieve this goal, Utah must increase the number of degrees and certificates awarded annually, to a level 25% above the 2010-11 base year level. This requires a continuing focused effort in creating a highly-educated workforce. A…

Space augmentation of military high-level waste disposal

NASA Technical Reports Server (NTRS)

English, T.; Lees, L.; Divita, E.

1979-01-01

Space disposal of selected components of military high-level waste (HLW) is considered. This disposal option offers the promise of eliminating the long-lived radionuclides in military HLW from the earth. A space mission which meets the dual requirements of long-term orbital stability and a maximum of one space shuttle launch per week over a period of 20-40 years, is a heliocentric orbit about halfway between the orbits of earth and Venus. Space disposal of high-level radioactive waste is characterized by long-term predictability and short-term uncertainties which must be reduced to acceptably low levels. For example, failure of either the Orbit Transfer Vehicle after leaving low earth orbit, or the storable propellant stage failure at perihelion would leave the nuclear waste package in an unplanned and potentially unstable orbit. Since potential earth reencounter and subsequent burn-up in the earth's atmosphere is unacceptable, a deep space rendezvous, docking, and retrieval capability must be developed.

Frequency response of portable PEF meters.

PubMed

Hankinson, J L; Das, M K

1995-08-01

Peak expiratory flow (PEF) is a dynamic parameter and therefore requires a measuring device with a high-frequency response. This study evaluated the frequency-response characteristics of eight commercially available PEF meters, using simulated forced-expiratory maneuvers with a computer-controlled mechanical pump. Three different PEF levels were used (200, 400, and 600 L/min) at six levels of harmonic-frequency content similar to those observed in human subjects. For waveforms with higher frequency content (at the high end or above the physiologic range), the Assess, Vitalograph, Pocket Peak, and Spir-O-Flow PEF meters all overread PEF (greater than 15% difference from target values) at all three PEF levels. These results suggest that the frequency response of PEF meters is an important consideration in the selection of such meters and should be included in device requirements. The current practice of using various levels of American Thoracic Society (ATS) waveform 24 with its low-frequency content may not adequately evaluate the frequency characteristics of PEF meters. An upper range (5% of the fundamental frequency) of 12 Hz, within the range observed in normal subjects, appears to be more practical than an upper limit of 20 Hz.

Establishment of a high accuracy geoid correction model and geodata edge match

NASA Astrophysics Data System (ADS)

Xi, Ruifeng

This research has developed a theoretical and practical methodology for efficiently and accurately determining sub-decimeter level regional geoids and centimeter level local geoids to meet regional surveying and local engineering requirements. This research also provides a highly accurate static DGPS network data pre-processing, post-processing and adjustment method and a procedure for a large GPS network like the state level HRAN project. The research also developed an efficient and accurate methodology to join soil coverages in GIS ARE/INFO. A total of 181 GPS stations has been pre-processed and post-processed to obtain an absolute accuracy better than 1.5cm at 95% of the stations, and at all stations having a 0.5 ppm average relative accuracy. A total of 167 GPS stations in Iowa and around Iowa have been included in the adjustment. After evaluating GEOID96 and GEOID99, a more accurate and suitable geoid model has been established in Iowa. This new Iowa regional geoid model improved the accuracy from a sub-decimeter 10˜20 centimeter to 5˜10 centimeter. The local kinematic geoid model, developed using Kalman filtering, gives results better than third order leveling accuracy requirement with 1.5 cm standard deviation.

COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene

NASA Technical Reports Server (NTRS)

Breault, D. T.; Lichtler, A. C.; Rowe, D. W.

1997-01-01

Collagen reporter gene constructs have be used to identify cell-specific sequences needed for transcriptional activation. The elements required for endogenous levels of COL1A1 expression, however, have not been elucidated. The human COL1A1 minigene is expressed at high levels and likely harbors sequence elements required for endogenous levels of activity. Using stably transfected osteoblastic Py1a cells, we studied a series of constructs (pOBColCAT) designed to characterize further the elements required for high level of expression. pOBColCAT, which contains the COL1A1 first intron, was expressed at 50-100-fold higher levels than ColCAT 3.6, which lacks the first intron. This difference is best explained by improved mRNA processing rather than a transcriptional effect. Furthermore, variation in activity observed with the intron deletion constructs is best explained by altered mRNA splicing. Two major regions of the human COL1A1 minigene, the 3'-flanking sequences and the minigene body, were introduced into pOBColCAT to assess both transcriptional enhancing activity and the effect on mRNA stability. Analysis of the minigene body, which includes the first five exons and introns fused with the terminal six introns and exons, revealed an orientation-independent 5-fold increase in CAT activity. In contrast the 3'-flanking sequences gave rise to a modest 61% increase in CAT activity. Neither region increased the mRNA half-life of the parent construct, suggesting that CAT-specific mRNA instability elements may serve as dominant negative regulators of stability. This study suggests that other sites within the body of the COL1A1 minigene are important for high expression, e.g. during periods of rapid extracellular matrix production.

An analysis of the back end of the nuclear fuel cycle with emphasis on high-level waste management, volume 1

NASA Technical Reports Server (NTRS)

1977-01-01

The programs and plans of the U.S. government for the "back end of the nuclear fuel cycle" were examined to determine if there were any significant technological or regulatory gaps and inconsistencies. Particular emphasis was placed on analysis of high-level nuclear waste management plans, since the permanent disposal of radioactive waste has emerged as a major factor in the public acceptance of nuclear power. The implications of various light water reactor fuel cycle options were examined including throwaway, stowaway, uranium recycle, and plutonium plus uranium recycle. The results of this study indicate that the U.S. program for high-level waste management has significant gaps and inconsistencies. Areas of greatest concern include: the adequacy of the scientific data base for geological disposal; programs for the the disposal of spent fuel rods; interagency coordination; and uncertainties in NRC regulatory requirements for disposal of both commercial and military high-level waste.

Identification of high-level functional/system requirements for future civil transports

NASA Technical Reports Server (NTRS)

Swink, Jay R.; Goins, Richard T.

1992-01-01

In order to accommodate the rapid growth in commercial aviation throughout the remainder of this century, the Federal Aviation Administration (FAA) is faced with a formidable challenge to upgrade and/or modernize the National Airspace System (NAS) without compromising safety or efficiency. A recurring theme in both the Aviation System Capital Investment Plan (CIP), which has replaced the NAS Plan, and the new FAA Plan for Research, Engineering, and Development (RE&D) rely on the application of new technologies and a greater use of automation. Identifying the high-level functional and system impacts of such modernization efforts on future civil transport operational requirements, particularly in terms of cockpit functionality and information transfer, was the primary objective of this project. The FAA planning documents for the NAS of the 2005 era and beyond were surveyed; major aircraft functional capabilities and system components required for such an operating environment were identified. A hierarchical structured analysis of the information processing and flows emanating from such functional/system components were conducted and the results documented in graphical form depicting the relationships between functions and systems.

The center of curvature optical assembly for the JWST primary mirror cryogenic optical test: optical verification

NASA Astrophysics Data System (ADS)

Wells, Conrad; Olczak, Gene; Merle, Cormic; Dey, Tom; Waldman, Mark; Whitman, Tony; Wick, Eric; Peer, Aaron

2010-08-01

The James Webb Space Telescope (JWST) Optical Telescope Element (OTE) consists of a 6.6 m clear aperture, allreflective, three-mirror anastigmat. The 18-segment primary mirror (PM) presents unique and challenging assembly, integration, alignment and testing requirements. A full aperture center of curvature optical test is performed in cryogenic vacuum conditions at the integrated observatory level to verify PM performance requirements. The Center of Curvature Optical Assembly (CoCOA), designed and being built by ITT satisfies the requirements for this test. The CoCOA contains a multi wave interferometer, patented reflective null lens, actuation for alignment, full in situ calibration capability, coarse and fine alignment sensing systems, as well as a system for monitoring changes in the PM to CoCOA distance. Two wave front calibration tests are utilized to verify the low and Mid/High spatial frequencies, overcoming the limitations of the standard null/hologram configuration in its ability to resolve mid and high spatial frequencies. This paper will introduce the systems level architecture and optical test layout for the CoCOA.

The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

PubMed Central

Castilho, Priscila V.; Williams, Byron C.; Mochida, Satoru; Zhao, Yong

2009-01-01

We have previously shown that Greatwall kinase (Gwl) is required for M phase entry and maintenance in Xenopus egg extracts. Here, we demonstrate that Gwl plays a crucial role in a novel biochemical pathway that inactivates, specifically during M phase, “antimitotic” phosphatases directed against phosphorylations catalyzed by cyclin-dependent kinases (CDKs). A major component of this phosphatase activity is heterotrimeric PP2A containing the B55δ regulatory subunit. Gwl is activated during M phase by Cdk1/cyclin B (MPF), but once activated, Gwl promotes PP2A/B55δ inhibition with no further requirement for MPF. In the absence of Gwl, PP2A/B55δ remains active even when MPF levels are high. The removal of PP2A/B55δ corrects the inability of Gwl-depleted extracts to enter M phase. These findings support the hypothesis that M phase requires not only high levels of MPF function, but also the suppression, through a Gwl-dependent mechanism, of phosphatase(s) that would otherwise remove MPF-driven phosphorylations. PMID:19793917

Ultrashort-pulse-train pump and dump excitation of a diatomic molecule

NASA Astrophysics Data System (ADS)

de Araujo, Luís E. E.

2010-09-01

An excitation scheme is proposed for transferring population between ground-vibrational levels of a molecule. The transfer is accomplished by pumping and dumping population with a pair of coherent ultrashort-pulse trains via a stationary state. By mismatching the teeth of the frequency combs associated with the pulse trains to the vibrational levels, high selectivity in the excitation, along with high transfer efficiency, is predicted. The pump-dump scheme does not suffer from spontaneous emission losses, it is insensitive to the pump-dump-train delay, and it requires only basic pulse shaping.

Amino acids of Diclidophora merlangi (Monogenea).

PubMed

Arme, C; Whyte, A

1975-02-01

The level of free amino acids in Diclidophora merlangi is high, comprising over 500 mu moles/g ethanol extracted dry weight. A single amino acid, proline, constitutes some 70% of the total pool. Analysis of parasite protein and host blood and mucus revealed low proline levels, suggesting that the high free pool content was not related to a requirement for protein systhesis or to its abundance in the diet of the worm. Experiments revealed that proline was not involved specifically in osmoregulation, and the reasons for the large amounts present in Diclidophora remain unknown.

Ultrashort-pulse-train pump and dump excitation of a diatomic molecule

DOE Office of Scientific and Technical Information (OSTI.GOV)

Araujo, Luis E. E. de

An excitation scheme is proposed for transferring population between ground-vibrational levels of a molecule. The transfer is accomplished by pumping and dumping population with a pair of coherent ultrashort-pulse trains via a stationary state. By mismatching the teeth of the frequency combs associated with the pulse trains to the vibrational levels, high selectivity in the excitation, along with high transfer efficiency, is predicted. The pump-dump scheme does not suffer from spontaneous emission losses, it is insensitive to the pump-dump-train delay, and it requires only basic pulse shaping.

Addressing Production System Failures Using Multi-agent Control

NASA Astrophysics Data System (ADS)

Gautam, Rajesh; Miyashita, Kazuo

Output in high-volume production facilities is limited by bottleneck machines. We propose a control mechanism by modeling workstations as agents that pull jobs from other agents based on their current WIP level and requirements. During failures, when flows of some jobs are disrupted, the agents pull alternative jobs to maintain utilization of their capacity at a high level. In this paper, we empirically demonstrate that the proposed mechanism can react to failures more appropriately than other control mechanisms using a benchmark problem of a semiconductor manufacturing process.

Recent developments in the design and verification of crystalline polarization scramblers for space applications

NASA Astrophysics Data System (ADS)

Dubroca, Guilhem; Richert, Michaël.; Loiseaux, Didier; Caron, Jérôme; Bézy, Jean-Loup

2015-09-01

To increase the accuracy of earth-observation spectro-imagers, it is necessary to achieve high levels of depolarization of the incoming beam. The preferred device in space instrument is the so-called polarization scrambler. It is made of birefringent crystal wedges arranged in a single or dual Babinet. Today, with required radiometric accuracies of the order of 0.1%, it is necessary to develop tools to find optimal and low sensitivity solutions quickly and to measure the performances with a high level of accuracy.

Functions and requirements document for interim store solidified high-level and transuranic waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith-Fewell, M.A., Westinghouse Hanford

1996-05-17

The functions, requirements, interfaces, and architectures contained within the Functions and Requirements (F{ampersand}R) Document are based on the information currently contained within the TWRS Functions and Requirements database. The database also documents the set of technically defensible functions and requirements associated with the solidified waste interim storage mission.The F{ampersand}R Document provides a snapshot in time of the technical baseline for the project. The F{ampersand}R document is the product of functional analysis, requirements allocation and architectural structure definition. The technical baseline described in this document is traceable to the TWRS function 4.2.4.1, Interim Store Solidified Waste, and its related requirements, architecture,more » and interfaces.« less

Increased levels of IAA are required for system 2 ethylene synthesis causing fruit softening in peach (Prunus persica L. Batsch)

PubMed Central

Tatsuki, Miho

2013-01-01

The fruit of melting-flesh peach (Prunus persica L. Batsch) cultivars produce high levels of ethylene caused by high expression of PpACS1 (an isogene of 1-aminocyclopropane-1-carboxylic acid synthase), resulting in rapid fruit softening at the late-ripening stage. In contrast, the fruit of stony hard peach cultivars do not soften and produce little ethylene due to low expression of PpACS1. To elucidate the mechanism for suppressing PpACS1 expression in stony hard peaches, a microarray analysis was performed. Several genes that displayed similar expression patterns as PpACS1 were identified and shown to be indole-3-acetic acid (IAA)-inducible genes (Aux/IAA, SAUR). That is, expression of IAA-inducible genes increased at the late-ripening stage in melting flesh peaches; however, these transcripts were low in mature fruit of stony hard peaches. The IAA concentration increased suddenly just before harvest time in melting flesh peaches exactly coinciding with system 2 ethylene production. In contrast, the IAA concentration did not increase in stony hard peaches. Application of 1-naphthalene acetic acid, a synthetic auxin, to stony hard peaches induced a high level of PpACS1 expression, a large amount of ethylene production and softening. Application of an anti-auxin, α-(phenylethyl-2-one)-IAA, to melting flesh peaches reduced levels of PpACS1 expression and ethylene production. These observations indicate that suppression of PpACS1 expression at the late-ripening stage of stony hard peach may result from a low level of IAA and that a high concentration of IAA is required to generate a large amount of system 2 ethylene in peaches. PMID:23364941

Determining robot actions for tasks requiring sensor interaction

NASA Technical Reports Server (NTRS)

Budenske, John; Gini, Maria

1989-01-01

The performance of non-trivial tasks by a mobile robot has been a long term objective of robotic research. One of the major stumbling blocks to this goal is the conversion of the high-level planning goals and commands into the actuator and sensor processing controls. In order for a mobile robot to accomplish a non-trivial task, the task must be described in terms of primitive actions of the robot's actuators. Most non-trivial tasks require the robot to interact with its environment; thus necessitating coordination of sensor processing and actuator control to accomplish the task. The main contention is that the transformation from the high level description of the task to the primitive actions should be performed primarily at execution time, when knowledge about the environment can be obtained through sensors. It is proposed to produce the detailed plan of primitive actions by using a collection of low-level planning components that contain domain specific knowledge and knowledge about the available sensors, actuators, and sensor/actuator processing. This collection will perform signal and control processing as well as serve as a control interface between an actual mobile robot and a high-level planning system. Previous research has shown the usefulness of high-level planning systems to plan the coordination of activities such to achieve a goal, but none have been fully applied to actual mobile robots due to the complexity of interacting with sensors and actuators. This control interface is currently being implemented on a LABMATE mobile robot connected to a SUN workstation and will be developed such to enable the LABMATE to perform non-trivial, sensor-intensive tasks as specified by a planning system.

Morphine, Endogenous Opioid Peptides, and Reproduction in the Male Rhesus Monkey

DTIC Science & Technology

1983-05-18

receptors are both antagonized at high dose levels, while at low doses , naloxone antagonizes only u-receptors (Kosterlitz, 1980). Studies of a...found witli the 20 ug/kg dose . As in the case of testosterone at the same dose , the LH pretreatment levels measured were unusually low (600 ng/dl vs...concentration of the dose of an- tagonist required to reduce agonistic potency by one-half. Due to differences in affinity, naloxone at low dose levels

High Energy Lithium-Ion VES Cells And Batteries Performances

NASA Astrophysics Data System (ADS)

Castric, A.-F.; Lawson, S.; Borthomieu, Y.

2011-10-01

b Saft's Space VES range of lithium-ion cells have been designed specifically to meet the satellites on-board power need, while meeting the legitimate high levels of requirements for space products. The purpose of the paper is to develop how the VES batteries designs have progressively evolved in order to accommodate the needs, requirements and constraints evolutions. The following topics will be presented: - Description of the main design features of the VES Li- ion batteries. - How the optimised battery configuration is selected against the required EOL power need or other constraints. - Presentation of the batteries performances (electrical, mechanical, thermal, interface, weight, ...). - Measures implemented in order to maintain these performances, and to guarantee the best product quality as per space standards.

Production of high-density highly-ionized helicon plasmas in the ProtoMPEX

NASA Astrophysics Data System (ADS)

Caneses, J. F.; Kafle, N.; Showers, M.; Goulding, R. H.; Biewer, T. M.; Caughman, J. B. O.; Bigelow, T.; Rapp, J.

2017-10-01

High-density (2-6e19 m-3) Deuterium helicon plasmas in the ProtoMPEX have been produced that successfully use differential pumping to produce neutral gas pressures suitable for testing the RF electron and ion heating concepts. To minimize collisional losses when heating electrons and ions, plasmas with very low neutral gas content (<< 0.1 Pa) in the heating sections are required. This requirement is typically not compatible with the neutral gas pressures (1-2 Pa) commonly used in high-density light-ion helicon sources. By using skimmers, a suitable gas injection scheme and long duration discharges (>0.3 s), high-density plasmas with very low neutral gas pressures (<< 0.1 Pa) in the RF heating sections have been produced. Measurements indicate the presence of a highly-ionized plasma column and that discharges lasting at least 0.3 s are required to significantly reduce the neutral gas pressure in the RF heating sections to levels suitable for investigating electron/ion RF heating concepts in this linear configuration. This work was supported by the US. D.O.E. contract DE-AC05-00OR22725.

Energetics of high-intensity exercise (soccer) with particular reference to fatigue.

PubMed

Reilly, T

1997-06-01

Soccer entails intermittent exercise with bouts of short, intense activity punctuating longer periods of low-level, moderate-intensity exercise. High levels of blood lactate may sometimes be observed during a match but the active recovery periods at submaximal exercise levels allow for its removal on a continual basis. While anaerobic efforts are evident in activity with the ball and shadowing fast-moving opponents, the largest strain is placed on aerobic metabolism. On average, competitive soccer corresponds to an energy expenditure of about 75% maximal aerobic power. The energy expenditure varies with playing position, being highest among midfield players. Muscle glycogen levels can be reduced towards the end of a game, the level of reduction being reflected in a decrease in work rate. Blood glucose levels are generally well-maintained, although body temperature may rise by 2 degrees C even in temperate conditions. The distance covered by players tends to under-reflect the energy expended. Unorthodox modes of motion-running backwards and sideways, accelerating, decelerating and changing direction-accentuate the metabolic loading. These are compounded by the extra requirements for energy associated with dribbling the ball and contesting possession. The overall energy expended is extreme when players are required to play extra-time in tournaments. Training, nutritional and tactical strategies may be used to reduce the effects of fatigue that may occur late in the game.

HEVC real-time decoding

NASA Astrophysics Data System (ADS)

Bross, Benjamin; Alvarez-Mesa, Mauricio; George, Valeri; Chi, Chi Ching; Mayer, Tobias; Juurlink, Ben; Schierl, Thomas

2013-09-01

The new High Efficiency Video Coding Standard (HEVC) was finalized in January 2013. Compared to its predecessor H.264 / MPEG4-AVC, this new international standard is able to reduce the bitrate by 50% for the same subjective video quality. This paper investigates decoder optimizations that are needed to achieve HEVC real-time software decoding on a mobile processor. It is shown that HEVC real-time decoding up to high definition video is feasible using instruction extensions of the processor while decoding 4K ultra high definition video in real-time requires additional parallel processing. For parallel processing, a picture-level parallel approach has been chosen because it is generic and does not require bitstreams with special indication.

High performance bilateral telerobot control.

PubMed

Kline-Schoder, Robert; Finger, William; Hogan, Neville

2002-01-01

Telerobotic systems are used when the environment that requires manipulation is not easily accessible to humans, as in space, remote, hazardous, or microscopic applications or to extend the capabilities of an operator by scaling motions and forces. The Creare control algorithm and software is an enabling technology that makes possible guaranteed stability and high performance for force-feedback telerobots. We have developed the necessary theory, structure, and software design required to implement high performance telerobot systems with time delay. This includes controllers for the master and slave manipulators, the manipulator servo levels, the communication link, and impedance shaping modules. We verified the performance using both bench top hardware as well as a commercial microsurgery system.

Current (2004-07) Conditions and Changes in Ground-Water Levels from Predevelopment to 2007, Southern High Plains Aquifer, East-Central New Mexico-Curry County, Portales, and Causey Lingo Underground Water Basins

USGS Publications Warehouse

Tillery, Anne

2008-01-01

The Southern High Plains aquifer is the principal aquifer in Curry and Roosevelt Counties, N. Mex., and primary source of water in southeastern New Mexico. Successful water-supply planning for New Mexico's Southern High Plains requires knowledge of the current aquifer conditions and a context to estimate future trends given current aquifer-management policy. This report provides a summary of the current (2007) water-level status of the Southern High Plains aquifer in New Mexico, including a basis for estimating future trends by comparison with historical conditions. This report includes estimates of the extent of ground-water level declines in the Curry County, Portales, and Causey-Lingo Ground-water Management Area parts of the High Plains Aquifer in eastern New Mexico since predevelopment. Maps representing 2007 water levels, water-level declines, aquifer saturated thickness, and depth to water accompanied by hydrographs from representative wells for the Southern High Plains aquifer in the Curry County, Portales, and Causey Lingo Underground Water Basins were prepared in cooperation with the New Mexico Office of the State Engineer. The results of this mapping show the water level declined as much as 175 feet in the study area at rates as high as 1.76 feet per year.

Validation of 1-hour post-thyroidectomy parathyroid hormone level in predicting hypocalcemia

PubMed Central

2014-01-01

Background Prior work by our group suggested that a single one hour post-thyroidectomy parathyroid hormone (1 hr PTH) level could accurately stratify patients into high and low risk groups for the development of hypocalcemia. This study looks to validate the safety and efficacy of a protocol based on a 1 hr PTH threshold of 12 pg/ml. Study design Retrospective analysis of consecutive cohort treated with standardized protocol. Methods One hundred and twenty five consecutive patients underwent total or completion thyroidectomy and their PTH level was drawn 1-hour post operatively. Based on our previous work, patients were stratified into either a low risk group (PTH < 12 pg/ml) or a high risk group (PTH ≥ 12 pg/ml). Patients in the high risk group were immediately started on prophylactic calcium carbonate (5–10 g/d) and calcitriol (0.5-1.0 mcg/d). The outcomes were then reviewed focusing mainly on how many low risk patients developed hypocalcemia (false negative rate), and how many high risk patients failed prophylactic therapy. Results Thirty one patients (25%) were stratified as high risk, and 94 (75%) as low risk. Five (16%) of the high risk patients became hypocalcemic despite prophylactic therapy. Two of the low risk group became hypocalcemic, (negative predictive value = 98%). None of the hypocalcemic patients had anything more than mild symptoms. Conclusions A single 1-hour post-thyroidectomy PTH level is a very useful way to stratify thyroidectomy patients into high and low risk groups for development of hypocalcemia. Early implementation of oral prophylactic calcium and vitamin D in the high risk patients is a very effective way to prevent serious hypocalcemia. Complex protocols requiring multiple calcium and PTH measurements are not required to guide post-thyroidectomy management. PMID:24476535

C-Band Airport Surface Communications System Standards Development. Phase II Final Report. Volume 1: Concepts of Use, Initial System Requirements, Architecture, and AeroMACS Design Considerations

NASA Technical Reports Server (NTRS)

Hall, Edward; Isaacs, James; Henriksen, Steve; Zelkin, Natalie

2011-01-01

This report is provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-Band and L-Band Communications Standard Development and was based on direction provided by FAA project-level agreements for New ATM Requirements-Future Communications. Task 7 included two subtasks. Subtask 7-1 addressed C-band (5091- to 5150-MHz) airport surface data communications standards development, systems engineering, test bed and prototype development, and tests and demonstrations to establish operational capability for the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2 focused on systems engineering and development support of the L-band digital aeronautical communications system (L-DACS). Subtask 7-1 consisted of two phases. Phase I included development of AeroMACS concepts of use, requirements, architecture, and initial high-level safety risk assessment. Phase II builds on Phase I results and is presented in two volumes. Volume I (this document) is devoted to concepts of use, system requirements, and architecture, including AeroMACS design considerations. Volume II describes an AeroMACS prototype evaluation and presents final AeroMACS recommendations. This report also describes airport categorization and channelization methodologies. The purposes of the airport categorization task were (1) to facilitate initial AeroMACS architecture designs and enable budgetary projections by creating a set of airport categories based on common airport characteristics and design objectives, and (2) to offer high-level guidance to potential AeroMACS technology and policy development sponsors and service providers. A channelization plan methodology was developed because a common global methodology is needed to assure seamless interoperability among diverse AeroMACS services potentially supplied by multiple service providers.

Adapting agriculture to climate change: a review

NASA Astrophysics Data System (ADS)

Anwar, Muhuddin Rajin; Liu, De Li; Macadam, Ian; Kelly, Georgina

2013-07-01

The agricultural sector is highly vulnerable to future climate changes and climate variability, including increases in the incidence of extreme climate events. Changes in temperature and precipitation will result in changes in land and water regimes that will subsequently affect agricultural productivity. Given the gradual change of climate in the past, historically, farmers have adapted in an autonomous manner. However, with large and discrete climate change anticipated by the end of this century, planned and transformational changes will be needed. In light of these, the focus of this review is on farm-level and farmers responses to the challenges of climate change both spatially and over time. In this review of adapting agriculture to climate change, the nature, extent, and causes of climate change are analyzed and assessed. These provide the context for adapting agriculture to climate change. The review identifies the binding constraints to adaptation at the farm level. Four major priority areas are identified to relax these constraints, where new initiatives would be required, i.e., information generation and dissemination to enhance farm-level awareness, research and development (R&D) in agricultural technology, policy formulation that facilitates appropriate adaptation at the farm level, and strengthening partnerships among the relevant stakeholders. Forging partnerships among R&D providers, policy makers, extension agencies, and farmers would be at the heart of transformational adaptation to climate change at the farm level. In effecting this transformational change, sustained efforts would be needed for the attendant requirements of climate and weather forecasting and innovation, farmer's training, and further research to improve the quality of information, invention, and application in agriculture. The investment required for these would be highly significant. The review suggests a sequenced approach through grouping research initiatives into short-term, medium-term, and long-term initiatives, with each initiative in one stage contributing to initiatives in a subsequent stage. The learning by doing inherent in such a process-oriented approach is a requirement owing to the many uncertainties associated with climate change.

Claspin Promotes Normal Replication Fork Rates in Human Cells

PubMed Central

Helleday, Thomas; Caldecott, Keith W.

2008-01-01

The S phase-specific adaptor protein Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of Chk1 by ataxia-telangiectasia and Rad3-related (ATR). Evidence suggests that these components of the ATR pathway also play a critical role during physiological S phase. Chk1 is required for high rates of global replication fork progression, and Claspin interacts with the replication machinery and might therefore monitor normal DNA replication. Here, we have used DNA fiber labeling to investigate, for the first time, whether human Claspin is required for high rates of replication fork progression during normal S phase. We report that Claspin-depleted HeLa and HCT116 cells display levels of replication fork slowing similar to those observed in Chk1-depleted cells. This was also true in primary human 1BR3 fibroblasts, albeit to a lesser extent, suggesting that Claspin is a universal requirement for high replication fork rates in human cells. Interestingly, Claspin-depleted cells retained significant levels of Chk1 phosphorylation at both Ser317 and Ser345, raising the possibility that Claspin function during normal fork progression may extend beyond facilitating phosphorylation of either individual residue. Consistent with this possibility, depletion of Chk1 and Claspin together doubled the percentage of very slow forks, compared with depletion of either protein alone. PMID:18353973

Clay Cuffman: A Cool, Calm, Relaxed Guy

ERIC Educational Resources Information Center

Booth, Gina

2010-01-01

This article describes Clay Cuffman, a simple clay-sculpture project that requires two or three sessions, and works for students from the upper-elementary level through high school. It takes about 1.5 pounds of clay per student--about the size of a small grapefruit. The Cuffman project is a great way for upper-elementary through high-school…

When Work Starts in Childhood: The Anticipatory Socialization Process of Classical Musicians

ERIC Educational Resources Information Center

Gabor, Elena

2009-01-01

Classical music is distinguished among professions in several ways: work has to start in childhood in order to achieve proficiency; the training takes an average of 16 years in order to become a professional musician (Manturzewska, 1990); the cost of training is high; a high level of discipline is required to develop performance abilities…

Impact of Teacher Qualification on Student Achievement at the Elementary and Middle School Levels

ERIC Educational Resources Information Center

Andrews, Sandra L.

2012-01-01

Although the federal No Child Left Behind (NCLB) Act requires that classroom teachers be highly qualified, the assumption that achieving the highly qualified endorsement equates to teacher effectiveness in the classroom is unverified. The purpose of this study was to compare the effect of teacher qualification, as defined by the NCLB Act and…

Building a High School Math Research Curriculum

ERIC Educational Resources Information Center

Gerver, Robert; Santucci, Lauren; Leventhal, Hanah

2017-01-01

For decades, all honors students at North Shore High School in New York were required to write a mathematics paper. In 1991, these papers were eliminated, and a new elective, "Investigations in Math Research," was added to the course catalog. Research is not an innate skill, and now, students of all ability levels who wanted the research…

An Examination of Transformational Leadership Practices by Public School Principals in Monmouth County, New Jersey

ERIC Educational Resources Information Center

Aldarelli, Edward

2017-01-01

The demands of high-stakes testing, tenure reform, and teacher accountability have dominated the landscape of education for almost two decades. The expectations placed on public schools require leadership that supports and motivates teachers to perform at extremely high levels. Public schools therefore must fill their institutions with principals…

Ex Ovo Model for Directly Visualizing Chick Embryo Development

ERIC Educational Resources Information Center

Dorrell, Michael I.; Marcacci, Michael; Bravo, Stephen; Kurz, Troy; Tremblay, Jacob; Rusing, Jack C.

2012-01-01

We describe a technique for removing and growing chick embryos in culture that utilizes relatively inexpensive materials and requires little space. It can be readily performed in class by university, high school, or junior high students, and teachers of any grade level should be able to set it up for their students. Students will be able to…

Core Principles and Test Item Development for Advanced High School and Introductory University Level Food Science

ERIC Educational Resources Information Center

Laing-Kean, Claudine A. M.

2010-01-01

Programs supported by the Carl D. Perkins Act of 2006 are required to operate under the state or national content standards, and are expected to carry out evaluation procedures that address accountability. The Indiana high school course, "Advanced Life Science: Foods" ("ALS: Foods") operates under the auspices of the Perkins…

Gender Differences in Introductory University Physics Performance: The Influence of High School Physics Preparation and Affective Factors

ERIC Educational Resources Information Center

Hazari, Zahra; Tai, Robert H.; Sadler, Philip M.

2007-01-01

The attrition of females studying physics after high school is a growing concern to the science education community. Most undergraduate science programs require introductory physics coursework. Thus, success in introductory physics is usually necessary for students to progress to higher levels of science study. Success also influences attitudes;…

StakeMeter: value-based stakeholder identification and quantification framework for value-based software systems.

PubMed

Babar, Muhammad Imran; Ghazali, Masitah; Jawawi, Dayang N A; Bin Zaheer, Kashif

2015-01-01

Value-based requirements engineering plays a vital role in the development of value-based software (VBS). Stakeholders are the key players in the requirements engineering process, and the selection of critical stakeholders for the VBS systems is highly desirable. Based on the stakeholder requirements, the innovative or value-based idea is realized. The quality of the VBS system is associated with the concrete set of valuable requirements, and the valuable requirements can only be obtained if all the relevant valuable stakeholders participate in the requirements elicitation phase. The existing value-based approaches focus on the design of the VBS systems. However, the focus on the valuable stakeholders and requirements is inadequate. The current stakeholder identification and quantification (SIQ) approaches are neither state-of-the-art nor systematic for the VBS systems. The existing approaches are time-consuming, complex and inconsistent which makes the initiation process difficult. Moreover, the main motivation of this research is that the existing SIQ approaches do not provide the low level implementation details for SIQ initiation and stakeholder metrics for quantification. Hence, keeping in view the existing SIQ problems, this research contributes in the form of a new SIQ framework called 'StakeMeter'. The StakeMeter framework is verified and validated through case studies. The proposed framework provides low-level implementation guidelines, attributes, metrics, quantification criteria and application procedure as compared to the other methods. The proposed framework solves the issues of stakeholder quantification or prioritization, higher time consumption, complexity, and process initiation. The framework helps in the selection of highly critical stakeholders for the VBS systems with less judgmental error.

Stress profile influences learning approach in a marine fish

PubMed Central

Trompf, Larissa; Williamson, Jane E.; Brown, Culum

2017-01-01

The spatial learning skills of high and low stress juvenile mulloway (Argyrosomus japonicus) were tested in a dichotomous choice apparatus. Groups of fish were formed based on background blood cortisol levels and required to learn the location of a food reward hidden in one of two compartments. Low stress fish characterised by low background levels of the stress hormone cortisol had higher activity levels and entered both rewarded and unrewarded rooms frequently. Within the first week of exposure, however, their preference for the rewarded room increased, indicative of learning. Fish that had high background levels of cortisol, in contrast, showed low levels of activity but when they chose between the two rooms they chose the rewarded room most often but showed less improvement over time. After 12 days in the apparatus, both low and high stress fish had similar ratios of rewarded vs unrewarded room entrances. Our results suggest that proactive coping styles may increase exposure to novel contexts and thus favour faster learning but at the cost of reduced initial accuracy. PMID:28607840

High level continuity for coordinate generation with precise controls

NASA Technical Reports Server (NTRS)

Eiseman, P. R.

1982-01-01

Coordinate generation techniques with precise local controls have been derived and analyzed for continuity requirements up to both the first and second derivatives, and have been projected to higher level continuity requirements from the established pattern. The desired local control precision was obtained when a family of coordinate surfaces could be uniformly distributed without a consequent creation of flat spots on the coordinate curves transverse to the family. Relative to the uniform distribution, the family could be redistributed from an a priori distribution function or from a solution adaptive approach, both without distortion from the underlying transformation which may be independently chosen to fit a nontrivial geometry and topology.

Rumination and Performance in Dynamic, Team Sport

PubMed Central

Roy, Michael M.; Memmert, Daniel; Frees, Anastasia; Radzevick, Joseph; Pretz, Jean; Noël, Benjamin

2016-01-01

People high in rumination are good at tasks that require persistence whereas people low in rumination is good at tasks that require flexibility. Here we examine real world implications of these differences in dynamic, team sport. In two studies, we found that professional male football (soccer) players from Germany and female field hockey players on the US national team were lower in rumination than were non-athletes. Further, low levels of rumination were associated with a longer career at a higher level in football players. Results indicate that athletes in dynamic, team sport might benefit from the flexibility associated with being low in rumination. PMID:26779110

The Advanced Gamma-ray Imaging System (AGIS) - Camera Electronics Development

NASA Astrophysics Data System (ADS)

Tajima, Hiroyasu; Bechtol, K.; Buehler, R.; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Hanna, D.; Horan, D.; Humensky, B.; Karlsson, N.; Kieda, D.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; Mukherjee, R.; Ong, R.; Otte, N.; Quinn, J.; Schroedter, M.; Swordy, S.; Wagner, R.; Wakely, S.; Weinstein, A.; Williams, D.; Camera Working Group; AGIS Collaboration

2010-03-01

AGIS, a next-generation imaging atmospheric Cherenkov telescope (IACT) array, aims to achieve a sensitivity level of about one milliCrab for gamma-ray observations in the energy band of 50 GeV to 100 TeV. Achieving this level of performance will require on the order of 50 telescopes with perhaps as many as 1M total electronics channels. The larger scale of AGIS requires a very different approach from the currently operating IACTs, with lower-cost and lower-power electronics incorporated into camera modules designed for high reliability and easy maintenance. Here we present the concept and development status of the AGIS camera electronics.

Low-level information and high-level perception: the case of speech in noise.

PubMed

Nahum, Mor; Nelken, Israel; Ahissar, Merav

2008-05-20

Auditory information is processed in a fine-to-crude hierarchical scheme, from low-level acoustic information to high-level abstract representations, such as phonological labels. We now ask whether fine acoustic information, which is not retained at high levels, can still be used to extract speech from noise. Previous theories suggested either full availability of low-level information or availability that is limited by task difficulty. We propose a third alternative, based on the Reverse Hierarchy Theory (RHT), originally derived to describe the relations between the processing hierarchy and visual perception. RHT asserts that only the higher levels of the hierarchy are immediately available for perception. Direct access to low-level information requires specific conditions, and can be achieved only at the cost of concurrent comprehension. We tested the predictions of these three views in a series of experiments in which we measured the benefits from utilizing low-level binaural information for speech perception, and compared it to that predicted from a model of the early auditory system. Only auditory RHT could account for the full pattern of the results, suggesting that similar defaults and tradeoffs underlie the relations between hierarchical processing and perception in the visual and auditory modalities.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This presentation provides a high-level overview of the current U.S. shared solar landscape, the impact that a given shared solar program's structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

Conceptual Design of a 50--100 MW Electron Beam Accelerator System for the National Hypersonic Wind Tunnel Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

SCHNEIDER,LARRY X.

2000-06-01

The National Hypersonic Wind Tunnel program requires an unprecedented electron beam source capable of 1--2 MeV at a beam power level of 50--100 MW. Direct-current electron accelerator technology can readily generate high average power beams to approximately 5 MeV at output efficiencies greater than 90%. However, due to the nature of research and industrial applications, there has never been a requirement for a single module with an output power exceeding approximately 500 kW. Although a 50--100 MW module is a two-order extrapolation from demonstrated power levels, the scaling of accelerator components appears reasonable. This paper presents an evaluation of componentmore » and system issues involved in the design of a 50--100 MW electron beam accelerator system with precision beam transport into a high pressure flowing air environment.« less

Object-oriented Approach to High-level Network Monitoring and Management

NASA Technical Reports Server (NTRS)

Mukkamala, Ravi

2000-01-01

An absolute prerequisite for the management of large investigating methods to build high-level monitoring computer networks is the ability to measure their systems that are built on top of existing monitoring performance. Unless we monitor a system, we cannot tools. Due to the heterogeneous nature of the hope to manage and control its performance. In this underlying systems at NASA Langley Research Center, paper, we describe a network monitoring system that we use an object-oriented approach for the design, we are currently designing and implementing. Keeping, first, we use UML (Unified Modeling Language) to in mind the complexity of the task and the required model users' requirements. Second, we identify the flexibility for future changes, we use an object-oriented existing capabilities of the underlying monitoring design methodology. The system is built using the system. Third, we try to map the former with the latter. APIs offered by the HP OpenView system.

Dissipative particle dynamics of diffusion-NMR requires high Schmidt-numbers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azhar, Mueed; Greiner, Andreas; Korvink, Jan G., E-mail: jan.korvink@kit.edu, E-mail: david.kauzlaric@imtek.uni-freiburg.de

We present an efficient mesoscale model to simulate the diffusion measurement with nuclear magnetic resonance (NMR). On the level of mesoscopic thermal motion of fluid particles, we couple the Bloch equations with dissipative particle dynamics (DPD). Thereby we establish a physically consistent scaling relation between the diffusion constant measured for DPD-particles and the diffusion constant of a real fluid. The latter is based on a splitting into a centre-of-mass contribution represented by DPD, and an internal contribution which is not resolved in the DPD-level of description. As a consequence, simulating the centre-of-mass contribution with DPD requires high Schmidt numbers. Aftermore » a verification for fundamental pulse sequences, we apply the NMR-DPD method to NMR diffusion measurements of anisotropic fluids, and of fluids restricted by walls of microfluidic channels. For the latter, the free diffusion and the localisation regime are considered.« less

Role of geophysics in identifying and characterizing sites for high-level nuclear waste repositories.

USGS Publications Warehouse

Wynn, J.C.; Roseboom, E.H.

1987-01-01

Evaluation of potential high-level nuclear waste repository sites is an area where geophysical capabilities and limitations may significantly impact a major governmental program. Since there is concern that extensive exploratory drilling might degrade most potential disposal sites, geophysical methods become crucial as the only nondestructive means to examine large volumes of rock in three dimensions. Characterization of potential sites requires geophysicists to alter their usual mode of thinking: no longer are anomalies being sought, as in mineral exploration, but rather their absence. Thus the size of features that might go undetected by a particular method take on new significance. Legal and regulatory considerations that stem from this different outlook, most notably the requirements of quality assurance (necessary for any data used in support of a repository license application), are forcing changes in the manner in which geophysicists collect and document their data. -Authors

Implementing a Cardiac Skills Orientation and Simulation Program.

PubMed

Hemingway, Maureen W; Osgood, Patrice; Mannion, Mildred

2018-02-01

Patients with cardiac morbidities admitted for cardiac surgical procedures require perioperative nurses with a high level of complex nursing skills. Orienting new cardiac team members takes commitment and perseverance in light of variable staffing levels, high-acuity patient populations, an active cardiac surgical schedule, and the unpredictability of scheduling patients undergoing cardiac transplantation. At an academic medical center in Boston, these issues presented opportunities to orient new staff members to the scrub person role, but hampered efforts to provide active learning opportunities in a safe environment. As a result, facility personnel created a program to increase new staff members' skills, confidence, and proficiency, while also increasing the number of staff members who were proficient at scrubbing complex cardiac procedures. To address the safe learning requirement, personnel designed a simulation program to provide scrubbing experience, decrease orientees' supervision time, and increase staff members' confidence in performing the scrub person role. © AORN, Inc, 2018.

Hazardous factories: Nigerian evidence.

PubMed

Oloyede, Olajide

2005-06-01

The past 15 years have seen an increasing governmental and corporate concern for the environment worldwide. For governments, information about the environmental performance of the industrial sector is required to inform macro-level decisions about environmental targets such as those required to meet UN directives. However, in many African, Asian, and Latin American countries, researching and reporting company environmental performance is limited. This article serves as a contribution to filling the gap by presenting evidence of physical and chemical risk in Nigerian factories. One hundred and three factories with a total of 5,021 workers were studied. One hundred and twenty physical and chemical hazards were identified and the result shows a high number of workers exposed to such hazards. The study also reveals that workers' awareness level of chemical hazards was high. Yet the danger was perceived in behavioral terms, especially by manufacturing firms, which tend to see environmental investment in an increasingly global economy as detrimental to profitability.

Neutron and gamma irradiation effects on power semiconductor switches

NASA Technical Reports Server (NTRS)

Schwarze, G. E.; Frasca, A. J.

1990-01-01

The performance characteristics of high-power semiconductor switches subjected to high levels of neutron fluence and gamma dose must be known by the designer of the power conditioning, control and transmission subsystem of space nuclear power systems. Location and the allowable shielding mass budget will determine the level of radiation tolerance required by the switches to meet performance and reliability requirements. Neutron and gamma ray interactions with semiconductor materials and how these interactions affect the electrical and switching characteristics of solid state power switches is discussed. The experimental measurement system and radiation facilities are described. Experimental data showing the effects of neutron and gamma irradiation on the performance characteristics are given for power-type NPN Bipolar Junction Transistors (BJTs), and Metal-Oxide-Semiconductor Field Effect Transistors (MOSFETs). BJTs show a rapid decrease in gain, blocking voltage, and storage time for neutron irradiation, and MOSFETs show a rapid decrease in the gate threshold voltage for gamma irradiation.

Neutron and gamma irradiation effects on power semiconductor switches

NASA Technical Reports Server (NTRS)

Schwarze, G. E.; Frasca, A. J.

1990-01-01

The performance characteristics of high power semiconductor switches subjected to high levels of neutron fluence and gamma dose must be known by the designer of the power conditioning, control and transmission subsystem of space nuclear power systems. Location and the allowable shielding mass budget will determine the level of radiation tolerance required by the switches to meet performance and reliability requirements. Neutron and gamma ray interactions with semiconductor materials and how these interactions affect the electrical and switching characteristics of solid state power switches is discussed. The experimental measurement system and radiation facilities are described. Experimental data showing the effects of neutron and gamma irradiation on the performance characteristics are given for power-type NPN Bipolar Junction Transistors (BJTs), and Metal-Oxide-Semiconductor Field Effect Transistors (MOSFETs). BJTs show a rapid decrease in gain, blocking voltage, and storage time for neutron irradiation, and MOSFETs show a rapid decrease in the gate threshold voltage for gamma irradiation.

Efficient high-quality volume rendering of SPH data.

PubMed

Fraedrich, Roland; Auer, Stefan; Westermann, Rüdiger

2010-01-01

High quality volume rendering of SPH data requires a complex order-dependent resampling of particle quantities along the view rays. In this paper we present an efficient approach to perform this task using a novel view-space discretization of the simulation domain. Our method draws upon recent work on GPU-based particle voxelization for the efficient resampling of particles into uniform grids. We propose a new technique that leverages a perspective grid to adaptively discretize the view-volume, giving rise to a continuous level-of-detail sampling structure and reducing memory requirements compared to a uniform grid. In combination with a level-of-detail representation of the particle set, the perspective grid allows effectively reducing the amount of primitives to be processed at run-time. We demonstrate the quality and performance of our method for the rendering of fluid and gas dynamics SPH simulations consisting of many millions of particles.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matlack, K. S.; Abramowitz, H.; Miller, I. S.

About 50 million gallons of high-level mixed waste is currently stored in underground tanks at the United States Department of Energy’s (DOE’s) Hanford site in the State of Washington. The Hanford Tank Waste Treatment and Immobilization Plant (WTP) will provide DOE’s Office of River Protection (ORP) with a means of treating this waste by vitrification for subsequent disposal. The tank waste will be separated into low- and high-activity waste fractions, which will then be vitrified respectively into Immobilized Low Activity Waste (ILAW) and Immobilized High Level Waste (IHLW) products. The ILAW product will be disposed in an engineered facility onmore » the Hanford site while the IHLW product is designed for acceptance into a national deep geological disposal facility for high-level nuclear waste. The ILAW and IHLW products must meet a variety of requirements with respect to protection of the environment before they can be accepted for disposal.« less

High-energy master oscillator power amplifier with near-diffraction-limited output based on ytterbium-doped PCF fiber

NASA Astrophysics Data System (ADS)

Li, Rao; Qiao, Zhi; Wang, Xiaochao; Fan, Wei; Lin, Zunqi

2017-10-01

With the development of fiber technologies, fiber lasers are able to deliver very high power beams and high energy pulses which can be used not only in scientific researches but industrial fields (laser marking, welding,…). The key of high power fiber laser is fiber amplifier. In this paper, we present a two-level master-oscillator power amplifier system at 1053 nm based on Yb-doped photonic crystal fibers. The system is used in the front-end of high power laser facility for the amplification of nano-second pulses to meet the high-level requirements. Thanks to the high gain of the system which is over 50 dB, the pulse of more than 0.89 mJ energy with the nearly diffraction-limited beam quality has been obtained.

[A case of GH and TSH secreting pituitary macroadenoma].

PubMed

Gołkowski, Filip; Buziak-Bereza, Monika; Stefańska, Agnieszka; Trofimiuk, Małgorzata; Pantofliński, Jacek; Huszno, Bohdan; Czepko, Ryszard; Adamek, Dariusz

2006-01-01

A case of GH and TSH secreting pituitary macroadenoma is reported. A 45-year-old female presented clinical features of acromegaly (the abnormal growth of the hands and feet, with lower jaw protrusion), diabetes mellitus, hypertension, nodular goiter and hyperthyroidism of unclear origin. NMR pituitary imaging revealed intra and extrasellar tumor. The laboratory examinations showed very high plasma levels of GH and IGF-1 and normal level of TSH coexisting with high plasma levels of free thyroid hormones. Pharmacological pretreatment with somatostatin analogues caused the substantial reduction of GH and TSH plasma levels. Histological and immunohistochemical examination of the tissue obtained at transsphenoidal surgery showed GH and TSH secreting adenoma. The laboratory examinations after surgery showed normal GH and IGF-1 plasma levels and reduced insulin requirement, what indicates radical operation. The very low plasma levels of TSH and free thyroid hormones after surgery and immunohistochemical examination suggest central hyperthyroidism due to TSH secreting pituitary tumor (thyrotropinoma).

Memorizing: a test of untrained mildly mentally retarded children's problem-solving.

PubMed

Belmont, J M; Ferretti, R P; Mitchell, D W

1982-09-01

Forty untrained mildly mentally retarded and 32 untrained nonretarded junior high school students were given eight trails of practice on a self-paced memory problem with lists of letters or words. For each trail a new list was presented, requiring ordered recall of terminal list items followed by ordered recall of initial items. Subgroups of solvers and nonsolvers were identified at each IQ level by a criterion of strict recall accuracy. Direct measures of mnemonic activity showed that over trails, solvers at both IQ levels increasingly fit a theoretically ideal memorization method. At neither IQ level did nonsolvers show similar inventions. On early trials, for both IQ levels, fit to the ideal method was uncorrelated with recall accuracy. On late trials fit and recall were highly correlated at each IQ level and across levels. The results support a problem-solving theory of individual differences in retarded and nonretarded children's memory performances.

Talking about health: correction employees' assessments of obstacles to healthy living.

PubMed

Morse, Tim; Dussetschleger, Jeffrey; Warren, Nicholas; Cherniack, Martin

2011-09-01

Describe health risks/obstacles to health among correctional employees. Mixed-methods approach combined results from four focus groups, 10 interviews, 335 surveys, and 197 physical assessments. Obesity levels were higher than national averages (40.7% overweight and 43.3% obese), with higher levels associated with job tenure, male gender, and working off-shift. Despite widespread concern about the lack of fitness, leisure exercise was higher than national norms. Respondents had higher levels of hypertension than national norms, with 31% of men and 25.8% of women hypertensive compared with 17.1% and 15.1% for national norms. Stress levels were elevated. Officers related their stress to concerns about security, administrative requirements, and work/family imbalance. High stress levels are reflected in elevated levels of hypertension. Correctional employees are at high risk for chronic disease, and environmental changes are needed to reduce risk factors. (C)2011The American College of Occupational and Environmental Medicine

Challenges for Service Robots-Requirements of Elderly Adults with Cognitive Impairments.

PubMed

Korchut, Agnieszka; Szklener, Sebastian; Abdelnour, Carla; Tantinya, Natalia; Hernández-Farigola, Joan; Ribes, Joan Carles; Skrobas, Urszula; Grabowska-Aleksandrowicz, Katarzyna; Szczęśniak-Stańczyk, Dorota; Rejdak, Konrad

2017-01-01

We focused on identifying the requirements and needs of people suffering from Alzheimer disease and early dementia stages with relation to robotic assistants. Based on focus groups performed in two centers (Poland and Spain), we created surveys for medical staff, patients, and caregivers, including: functional requirements; human-robot interaction, the design of the robotic assistant and user acceptance aspects. Using Likert scale and analysis made on the basis of the frequency of survey responses, we identified users' needs as high, medium, and low priority. We gathered 264 completed surveys (100 from medical staff, 81 from caregivers, and 83 from potential users). Most of the respondents, almost at the same level in each of the three groups, accept robotic assistants and their support in everyday life. High level priority functional requirements were related to reacting in emergency situations (calling for help, detecting/removing obstacles) and to reminding about medication intake, about boiling water, turning off the gas and lights (almost 60% of answers). With reference to human-robot interaction, high priority was given to voice operated system and the capability of robotic assistants to reply to simple questions. Our results help in achieving better understanding of the needs of patients with cognitive impairments during home tasks in everyday life. This way of conducting the research, with considerations for the interests of three stakeholder groups in two autonomic centers with proven experience regarding the needs of our patient groups, highlights the importance of obtained results.

Noise levels and their effects on Shuttle crewmembers' performance: Operational concerns

NASA Technical Reports Server (NTRS)

Koros, Anton S.; Adam, Susan C.; Wheelwright, Charles D.

1993-01-01

When excessive, noise can result in sleep interference, fatigue, interference with verbal communication, and hearing damage. Shuttle crewmembers are exposed to noise throughout their mission. The contribution of noise to decrements in crew performance over these extended exposure durations was the focus of this study. On the STS-40/SLS-1, mission noise levels were evaluated through the use of a sound level meter and a crew questionnaire. Crewmembers noted that sleep, concentration, and relaxation were negatively impacted by high noise levels. Speech Interference Levels (SIL's), calculated from the sound level measurements, suggested that crewmembers were required to raise their voice in order to be heard. No difficulty detecting caution and warning alarms was noted. The higher than desirable noise levels in Spacelab were attributed to flight specific payloads for which acoustic waivers were granted. It is recommended that current noise levels be reduced in Spacelab and the Orbiter Middeck especially as longer missions are planned for the buildup of Space Station Freedom. Levels of NC 50 are recommended in areas where speech communication is required and NC 40 in sleep areas. These levels are in accordance with the NASA Man-Systems Integration Standards. Measurements proposed for subsequent orbiter missions are discussed.

Enhancement of Immune Memory Responses to Respiratory Infection

DTIC Science & Technology

2017-08-01

induction of highly specific B and T cell responses against viral infections. Despite recent progress in vaccine development, the molecular mechanisms...highly expressed in memory B cells in mice, and Atg7 is required for maintenance of long-term memory B cells needed to protect against influenza...infection. Human influenza-specific memory B cells also have high levels of autophagy, but whether autophagy protects memory B cell survival in humans

RF System Requirements for a Medium-Energy Electron-Ion Collider (MEIC) at JLab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rimmer, Robert A; Hannon, Fay E; Guo, Jiquan

2015-09-01

JLab is studying options for a medium energy electron-ion collider that could fit on the JLab site and use CEBAF as a full-energy electron injector. A new ion source, linac and booster would be required, together with collider storage rings for the ions and electrons. In order to achieve the maximum luminosity these will be high-current storage rings with many bunches. We present the high-level RF system requirements for the storage rings, ion booster ring and high-energy ion beam cooling system, and describe the technology options under consideration to meet them. We also present options for staging that might reducemore » the initial capital cost while providing a smooth upgrade path to a higher final energy. The technologies under consideration may also be useful for other proposed storage ring colliders or ultimate light sources.« less

Ultralow-mass solar-array designs for Halley's comet rendezvous mission

NASA Technical Reports Server (NTRS)

Costogue, E. N.; Rayl, G.

1978-01-01

This paper describes the conceptual design study results of photovoltaic arrays capable of powering a Halley's comet rendezvous mission. This mission would be Shuttle-launched, employ a unique form of propulsion (ion drive) which requires high power levels for operation, and operate at distances between 0.6 and 4.5 AU. These requirements make it necessary to develop arrays with extremely high power-to-mass ratio (200 W/kg). In addition, the dual requirements of providing ion thruster power as well as housekeeping power leads to the development of unique methods for mode switching. Both planar and variable-concentrator-enhanced array concepts using ultrathin (50 micron) high-efficiency (up to 12.5%) silicon solar cells coupled with thin (75 micron) plastic encapsulants are considered. In order to satisfy the Shuttle launch environment it was necessary to provide novel methods of both storing and deploying these arrays.

Prevalence and correlates of psychological distress among drug users in Phnom Penh, Cambodia.

PubMed

Yi, Siyan; Tuot, Sovannary; Chhoun, Pheak; Pal, Khuondyla; Choub, Sok Chamreun; Mburu, Gitau

2016-10-01

Compared to the general population, drug users are at increased risk of both poor mental health and HIV infection. The aim of this study was to determine the prevalence and correlates of high psychological distress among drug users in Cambodia. In April 2014, a two-stage cluster sampling method was used to randomly select 169 drug users from hotspots in Phnom Penh. Psychological distress was measured using General Health Questionnaire (GHQ-12). Bivariate and multivariable analyses were conducted to identify factors associated with levels of psychological distress among this population. Our study found high prevalence of attempted suicide (15.3%), drug related arrests (46.2%), and incarceration (31.4%). Of the 169 participants, 42.0% were found to have high levels of psychological distress, indicating poor mental health. After adjustment, high levels of psychological distress were independently associated with suicidal ideation (p<0.001), higher frequency of drug use (p=0.02), sharing of needles or syringes (p=0.005), and having been sent to a rehabilitation centre (p=0.02). In addition, participants who perceived their overall health as being poor or very poor were more likely to have high levels of psychological distress (p=0.002). Integration of mental health within HIV and needle and syringe exchange programmes is required to address psychological distress among drug users in Cambodia. Health system interventions, such as screening, referral, and training of health providers, need to be strengthened. In addition, interventions addressing social determinants of mental health and mitigation of frequent arrests and improving conditions in rehabilitation centres are required. Copyright © 2016 Elsevier B.V. All rights reserved.

Evaluating activation of the shielding walls of a treatment room using the Monte Carlo method

NASA Astrophysics Data System (ADS)

Lee, D.-Y.; Kim, J.-H.

2018-05-01

This study investigates the radiation activation process in a medical linear accelerator, which creates a photon beam with the energy acquired from accelerated electrons. The concrete shielding walls used in conjunction with a medical linear accelerator occupy the largest portion of facility decommissioning costs. Therefore, to evaluate the activation of the shielding wall, this study simulated the operation of a linear accelerator with high-energy photon beams (10, 15, and 20 MV). The results of the simulations showed that the high-energy photon beams produced a large number of neutrons in the areas around the linear accelerator head. Several radionuclides were identified, and their half-lives and radioactivity levels were calculated. Half-lives ranged from 2.62 hours to 3.68E+06 years, and the radioactivity levels of most of the radionuclides were found to satisfy their respective clearance requirements. These results indicate that photon beams of 15 MV or lower satisfy the clearance requirements for decommissioning a linear accelerator facility, whereas those of 20 MV or higher lie partially above the regulatory clearance levels.

An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition.

PubMed

Benoit, Beatrice; He, Chun Hua; Zhang, Fan; Votruba, Sarah M; Tadros, Wael; Westwood, J Timothy; Smibert, Craig A; Lipshitz, Howard D; Theurkauf, William E

2009-03-01

Genetic control of embryogenesis switches from the maternal to the zygotic genome during the maternal-to-zygotic transition (MZT), when maternal mRNAs are destroyed, high-level zygotic transcription is initiated, the replication checkpoint is activated and the cell cycle slows. The midblastula transition (MBT) is the first morphological event that requires zygotic gene expression. The Drosophila MBT is marked by blastoderm cellularization and follows 13 cleavage-stage divisions. The RNA-binding protein Smaug is required for cleavage-independent maternal transcript destruction during the Drosophila MZT. Here, we show that smaug mutants also disrupt syncytial blastoderm stage cell-cycle delays, DNA replication checkpoint activation, cellularization, and high-level zygotic expression of protein coding and micro RNA genes. We also show that Smaug protein levels increase through the cleavage divisions and peak when the checkpoint is activated and zygotic transcription initiates, and that transgenic expression of Smaug in an anterior-to-posterior gradient produces a concomitant gradient in the timing of maternal transcript destruction, cleavage cell cycle delays, zygotic gene transcription, cellularization and gastrulation. Smaug accumulation thus coordinates progression through the MZT.

Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chotiyarnwong, Pojchong; Medical Molecular Biology Unit, Faculty of Medicine, Siriraj Hospital, Mahidol University; Stewart-Jones, Guillaume B.

Crystals of an MHC class I molecule bound to naturally occurring peptide variants from the dengue virus NS3 protein contained high levels of solvent and required optimization of cryoprotectant and dehydration protocols for each complex to yield well ordered diffraction, a process facilitated by the use of a free-mounting system. T-cell recognition of the antigenic peptides presented by MHC class I molecules normally triggers protective immune responses, but can result in immune enhancement of disease. Cross-reactive T-cell responses may underlie immunopathology in dengue haemorrhagic fever. To analyze these effects at the molecular level, the functional MHC class I molecule HLA-A*1101more » was crystallized bound to six naturally occurring peptide variants from the dengue virus NS3 protein. The crystals contained high levels of solvent and required optimization of the cryoprotectant and dehydration protocols for each complex to yield well ordered diffraction, a process that was facilitated by the use of a free-mounting system.« less

A DC Transformer

NASA Technical Reports Server (NTRS)

Youngquist, Robert C.; Ihlefeld, Curtis M.; Starr, Stanley O.

2013-01-01

A component level dc transformer is described in which no alternating currents or voltages are present. It operates by combining features of a homopolar motor and a homopolar generator, both de devices, such that the output voltage of a de power supply can be stepped up (or down) with a corresponding step down (or up) in current. The basic theory for this device is developed, performance predictions are made, and the results from a small prototype are presented. Based on demonstrated technology in the literature, this de transformer should be scalable to low megawatt levels, but it is more suited to high current than high voltage applications. Significant development would be required before it could achieve the kilovolt levels needed for de power transmission.

Advanced supersonic propulsion study. [with emphasis on noise level reduction

NASA Technical Reports Server (NTRS)

Sabatella, J. A. (Editor)

1974-01-01

A study was conducted to determine the promising propulsion systems for advanced supersonic transport application, and to identify the critical propulsion technology requirements. It is shown that noise constraints have a major effect on the selection of the various engine types and cycle parameters. Several promising advanced propulsion systems were identified which show the potential of achieving lower levels of sideline jet noise than the first generation supersonic transport systems. The non-afterburning turbojet engine, utilizing a very high level of jet suppression, shows the potential to achieve FAR 36 noise level. The duct-heating turbofan with a low level of jet suppression is the most attractive engine for noise levels from FAR 36 to FAR 36 minus 5 EPNdb, and some series/parallel variable cycle engines show the potential of achieving noise levels down to FAR 36 minus 10 EPNdb with moderate additional penalty. The study also shows that an advanced supersonic commercial transport would benefit appreciably from advanced propulsion technology. The critical propulsion technology needed for a viable supersonic propulsion system, and the required specific propulsion technology programs are outlined.

Chance-constrained economic dispatch with renewable energy and storage

DOE PAGES

Cheng, Jianqiang; Chen, Richard Li-Yang; Najm, Habib N.; ...

2018-04-19

Increased penetration of renewables, along with uncertainties associated with them, have transformed how power systems are operated. High levels of uncertainty means that it is not longer possible to guarantee operational feasibility with certainty, instead constraints are required to be satisfied with high probability. We present a chance-constrained economic dispatch model that efficiently integrates energy storage and high renewable penetration to satisfy renewable portfolio requirements. Specifically, it is required that wind energy contributes at least a prespecified ratio of the total demand and that the scheduled wind energy is dispatchable with high probability. We develop an approximated partial sample averagemore » approximation (PSAA) framework to enable efficient solution of large-scale chanceconstrained economic dispatch problems. Computational experiments on the IEEE-24 bus system show that the proposed PSAA approach is more accurate, closer to the prescribed tolerance, and about 100 times faster than sample average approximation. Improved efficiency of our PSAA approach enables solution of WECC-240 system in minutes.« less

Chance-constrained economic dispatch with renewable energy and storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, Jianqiang; Chen, Richard Li-Yang; Najm, Habib N.

Increased penetration of renewables, along with uncertainties associated with them, have transformed how power systems are operated. High levels of uncertainty means that it is not longer possible to guarantee operational feasibility with certainty, instead constraints are required to be satisfied with high probability. We present a chance-constrained economic dispatch model that efficiently integrates energy storage and high renewable penetration to satisfy renewable portfolio requirements. Specifically, it is required that wind energy contributes at least a prespecified ratio of the total demand and that the scheduled wind energy is dispatchable with high probability. We develop an approximated partial sample averagemore » approximation (PSAA) framework to enable efficient solution of large-scale chanceconstrained economic dispatch problems. Computational experiments on the IEEE-24 bus system show that the proposed PSAA approach is more accurate, closer to the prescribed tolerance, and about 100 times faster than sample average approximation. Improved efficiency of our PSAA approach enables solution of WECC-240 system in minutes.« less

A Comparison of Higher-Order Thinking between the Common Core State Standards and the 2009 New Jersey Content Standards in High School

ERIC Educational Resources Information Center

Sforza, Dario; Tienken, Christopher H.; Kim, Eunyoung

2016-01-01

The creators and supporters of the Common Core State Standards claim that the Standards require greater emphasis on higher-order thinking than previous state standards in mathematics and English language arts. We used a qualitative case study design with content analysis methods to test the claim. We compared the levels of thinking required by the…

Suitability of representative electrochemical energy storage technologies for ramp-rate control of photovoltaic power

NASA Astrophysics Data System (ADS)

Jiang, Yu; Fletcher, John; Burr, Patrick; Hall, Charles; Zheng, Bowen; Wang, Da-Wei; Ouyang, Zi; Lennon, Alison

2018-04-01

Photovoltaic (PV) systems can exhibit rapid variances in their power output due to irradiance changes which can destabilise an electricity grid. This paper presents a quantitative comparison of the suitability of different electrochemical energy storage system (ESS) technologies to provide ramp-rate control of power in PV systems. Our investigations show that, for PV systems ranging from residential rooftop systems to megawatt power systems, lithium-ion batteries with high energy densities (up to 600 Wh L-1) require the smallest power-normalised volumes to achieve the ramp rate limit of 10% min-1 with 100% compliance. As the system size increases, the ESS power-normalised volume requirements are significantly reduced due to aggregated power smoothing, with high power lithium-ion batteries becoming increasingly more favourable with increased PV system size. The possibility of module-level ramp-rate control is also introduced, and results show that achievement of a ramp rate of 10% min-1 with 100% compliance with typical junction box sizes will require ESS energy and power densities of 400 Wh L-1 and 2300 W L-1, respectively. While module-level ramp-rate control can reduce the impact of solar intermittence, the requirement is challenging, especially given the need for low cost and long cycle life.

Aerobic conditioning for team sport athletes.

PubMed

Stone, Nicholas M; Kilding, Andrew E

2009-01-01

Team sport athletes require a high level of aerobic fitness in order to generate and maintain power output during repeated high-intensity efforts and to recover. Research to date suggests that these components can be increased by regularly performing aerobic conditioning. Traditional aerobic conditioning, with minimal changes of direction and no skill component, has been demonstrated to effectively increase aerobic function within a 4- to 10-week period in team sport players. More importantly, traditional aerobic conditioning methods have been shown to increase team sport performance substantially. Many team sports require the upkeep of both aerobic fitness and sport-specific skills during a lengthy competitive season. Classic team sport trainings have been shown to evoke marginal increases/decreases in aerobic fitness. In recent years, aerobic conditioning methods have been designed to allow adequate intensities to be achieved to induce improvements in aerobic fitness whilst incorporating movement-specific and skill-specific tasks, e.g. small-sided games and dribbling circuits. Such 'sport-specific' conditioning methods have been demonstrated to promote increases in aerobic fitness, though careful consideration of player skill levels, current fitness, player numbers, field dimensions, game rules and availability of player encouragement is required. Whilst different conditioning methods appear equivalent in their ability to improve fitness, whether sport-specific conditioning is superior to other methods at improving actual game performance statistics requires further research.

DOE Office of Scientific and Technical Information (OSTI.GOV)

GOLDSTON, WELFORD T.; SMITH, WINCHESTER IV

DOE issued Order 435.1, ''Radioactive Waste Management,'' on July 9, 1999 for immediate implementation. The requirements for Low Level Mixed, Transuranic, and High Level Waste have been completely rewritten. The entire DOE complex has been struggling with how to implement these new requirements within the one year required timeframe. This paper will chronicle the implementation strategy and actual results of the work to carry out that strategy at the Savannah River Site. DOE-SR and the site contractors worked closely together to implement each of the new requirements across the SRS, crossing many barriers and providing innovative solutions to the manymore » problems that surfaced throughout the year. The results are that SRS declared compliance with all of the requirements of the Order within the prescribed timeframe. The challenge included all waste types in SRS facilities and programs that handle LLW, MLLW, TRU, and HLW. This paper will describe the implementation details for development of Radioactive Waste Management Basis for each facility, Identification of Wastes with No Path to Disposal, Waste Incidental to Reprocessing Determinations, Low Level Waste 90-Day Staging and One Year Limits for Storage Programs, to name a few of the requirements that were addressed by the SRS 435.1 Implementation Team. This paper will trace the implementation, problems (both technical and administrative), and the current pushback efforts associated with the DOE ''Top-to-Bottom'' review.« less

Design for interaction between humans and intelligent systems during real-time fault management

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Schreckenghost, Debra L.; Thronesbery, Carroll G.

1992-01-01

Initial results are reported to provide guidance and assistance for designers of intelligent systems and their human interfaces. The objective is to achieve more effective human-computer interaction (HCI) for real time fault management support systems. Studies of the development of intelligent fault management systems within NASA have resulted in a new perspective of the user. If the user is viewed as one of the subsystems in a heterogeneous, distributed system, system design becomes the design of a flexible architecture for accomplishing system tasks with both human and computer agents. HCI requirements and design should be distinguished from user interface (displays and controls) requirements and design. Effective HCI design for multi-agent systems requires explicit identification of activities and information that support coordination and communication between agents. The effects are characterized of HCI design on overall system design and approaches are identified to addressing HCI requirements in system design. The results include definition of (1) guidance based on information level requirements analysis of HCI, (2) high level requirements for a design methodology that integrates the HCI perspective into system design, and (3) requirements for embedding HCI design tools into intelligent system development environments.

Homologous Recombination Repair Factors Rad51 and BRCA1 Are Necessary for Productive Replication of Human Papillomavirus 31.

PubMed

Chappell, William H; Gautam, Dipendra; Ok, Suzan T; Johnson, Bryan A; Anacker, Daniel C; Moody, Cary A

2015-12-23

High-risk human papillomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage response (DDR), which is necessary for productive viral replication. In response to DNA double-strand breaks (DSBs), ATM activation leads to DNA repair through homologous recombination (HR), which requires the principal recombinase protein Rad51, as well as BRCA1. Previous studies from our lab demonstrated that Rad51 and BRCA1 are expressed at high levels in HPV31-positive cells and localize to sites of viral replication. These results suggest that HPV may utilize ATM activity to increase HR activity as a means to facilitate viral replication. In this study, we demonstrate that high-risk HPV E7 expression alone is sufficient for the increase in Rad51 and BRCA1 protein levels. We have found that this increase occurs, at least in part, at the level of transcription. Studies analyzing protein stability indicate that HPV may also protect Rad51 and BRCA1 from turnover, contributing to the overall increase in cellular levels. We also demonstrate that Rad51 is bound to HPV31 genomes, with binding increasing per viral genome upon productive replication. We have found that depletion of Rad51 and BRCA1, as well as inhibition of Rad51's recombinase activity, abrogates productive viral replication upon differentiation. Overall, these results indicate that Rad51 and BRCA1 are required for the process of HPV31 genome amplification and suggest that productive replication occurs in a manner dependent upon recombination. Productive replication of HPV31 requires activation of an ATM-dependent DNA damage response, though how ATM activity contributes to replication is unclear. Rad51 and BRCA1 play essential roles in repair of double-strand breaks, as well as the restart of stalled replication forks through homologous recombination (HR). Given that ATM activity is required to initiate HR repair, coupled with the requirement of Rad51 and BRCA1 for productive viral replication, our findings suggest that HPV may utilize ATM activity to ensure localization of recombination factors to productively replicating viral genomes. The finding that E7 increases the levels of Rad51 and BRCA1 suggests that E7 contributes to productive replication by providing DNA repair factors required for viral DNA synthesis. Our studies not only imply a role for recombination in the regulation of productive HPV replication but provide further insight into how HPV manipulates the DDR to facilitate the productive phase of the viral life cycle. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Assessing the Impacts of Wind Integration in the Western Provinces

NASA Astrophysics Data System (ADS)

Sopinka, Amy

Increasing carbon dioxide levels and the fear of irreversible climate change has prompted policy makers to implement renewable portfolio standards. These renewable portfolio standards are meant to encourage the adoption of renewable energy technologies thereby reducing carbon emissions associated with fossil fuel-fired electricity generation. The ability to efficiently adopt and utilize high levels of renewable energy technology, such as wind power, depends upon the composition of the extant generation within the grid. Western Canadian electric grids are poised to integrate high levels of wind and although Alberta has sufficient and, at times, an excess supply of electricity, it does not have the inherent generator flexibility required to mirror the variability of its wind generation. British Columbia, with its large reservoir storage capacities and rapid ramping hydroelectric generation could easily provide the firming services required by Alberta; however, the two grids are connected only by a small, constrained intertie. We use a simulation model to assess the economic impacts of high wind penetrations in the Alberta grid under various balancing protocols. We find that adding wind capacity to the system impacts grid reliability, increasing the frequency of system imbalances and unscheduled intertie flow. In order for British Columbia to be viable firming resource, it must have sufficient generation capability to meet and exceed the province's electricity self-sufficiency requirements. We use a linear programming model to evaluate the province's ability to meet domestic load under various water and trade conditions. We then examine the effects of drought and wind penetration on the interconnected Alberta -- British Columbia system given differing interconnection sizes.

Design of automatic leveling and centering system of theodolite

NASA Astrophysics Data System (ADS)

Liu, Chun-tong; He, Zhen-Xin; Huang, Xian-xiang; Zhan, Ying

2012-09-01

To realize the theodolite automation and improve the azimuth Angle measurement instrument, the theodolite automatic leveling and centering system with the function of leveling error compensation is designed, which includes the system solution, key components selection, the mechanical structure of leveling and centering, and system software solution. The redesigned leveling feet are driven by the DC servo motor; and the electronic control center device is installed. Using high precision of tilt sensors as horizontal skew detection sensors ensures the effectiveness of the leveling error compensation. Aiming round mark center is located using digital image processing through surface array CCD; and leveling measurement precision can reach the pixel level, which makes the theodolite accurate centering possible. Finally, experiments are conducted using the automatic leveling and centering system of the theodolite. The results show the leveling and centering system can realize automatic operation with high centering accuracy of 0.04mm.The measurement precision of the orientation angle after leveling error compensation is improved, compared with that of in the traditional method. Automatic leveling and centering system of theodolite can satisfy the requirements of the measuring precision and its automation.

Vitamin A nutritional status in high- and low-income postpartum women and its effect on colostrum and the requirements of the term newborn.

PubMed

Gurgel, Cristiane Santos Sânzio; Grilo, Evellyn C; Lira, Larissa Q; Assunção, Débora G F; Oliveira, Priscila G; Melo, Larisse R M de; de Medeiros, Silvia V; Pessanha, Luanna C; Dimenstein, Roberto; Lyra, Clélia O

To evaluate the vitamin A status in serum and colostrum of postpartum women with different socioeconomic status, comparing the colostrum retinol supply with the vitamin A requirement of the newborn. Cross-sectional study conducted with 424 postpartum women. Vitamin A maternal dietary intake was estimated using a food frequency questionnaire. Colostrum and serum retinol levels were measured by high performance liquid chromatography (HPLC). Serum retinol concentrations <20μg/dL were indicative of vitamin A deficiency (VAD). Vitamin A levels provided by colostrum <400μgRAE/day were considered as insufficient for term newborns. The mean maternal vitamin A intake during pregnancy was 872.2±639.2μgRAE/day in low-income women and 1169.2±695.2μgRAE/day for high-income women (p<0.005). The prevalence of vitamin A deficiency was 6.9% (n=18) in the low-income group and 3.7% (n=6) in the high-income group. The estimated mean retinol intake by infants of the high- and low-income mothers were 343.3μgRAE/day (85.8% AI) and 427.2μgRAE/day (106.8% AI), respectively. Serum vitamin A deficiency was considered a mild public health problem in both populations; however, newborns of low-income women were more likely to receive lower retinol levels through colostrum when compared with newborns of high-income mothers. Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

Phospholipase C mediated Suppression of Dark Noise Enables Single Photon Detection in Drosophila Photoreceptors

PubMed Central

Katz, Ben; Minke, Baruch

2012-01-01

Drosophila photoreceptor cells use the ubiquitous G-protein-mediated phospholipase C (PLC) cascade to achieve ultimate single photon sensitivity. This is manifested in the single photon responses (quantum bumps). In photoreceptor cells, dark activation of Gqα molecules occurs spontaneously and produces unitary dark events (dark bumps). A high rate of spontaneous Gqα activation and dark bump production potentially hampers single photon detection. We found that in wild type flies the in vivo rate of spontaneous Gqα activation is very high. Nevertheless, this high rate is not manifested in a substantially high rate of dark bumps. Therefore, it is unclear how phototransduction suppresses dark bump production, arising from spontaneous Gqα activation, while still maintaining high-fidelity representation of single photons. In this study we show that reduced PLC catalytic activity selectively suppressed production of dark bumps but not light-induced bumps. Manipulations of PLC activity using PLC mutant flies and Ca2+ modulations revealed that a critical level of PLC activity is required to induce bump production. The required minimal level of PLC activity, selectively suppressed random production of single Gqα-activated dark bumps despite a high rate of spontaneous Gqα activation. This minimal PLC activity level is reliably obtained by photon induced synchronized activation of several neighboring Gqα molecules activating several PLC molecules, but not by random activation of single Gqα molecules. We thus demonstrate how a G-protein-mediated transduction system, with PLC as its target, selectively suppresses its intrinsic noise while preserving reliable signaling. PMID:22357856

Real-time flood forecasting by employing artificial neural network based model with zoning matching approach

NASA Astrophysics Data System (ADS)

Sulaiman, M.; El-Shafie, A.; Karim, O.; Basri, H.

2011-10-01

Flood forecasting models are a necessity, as they help in planning for flood events, and thus help prevent loss of lives and minimize damage. At present, artificial neural networks (ANN) have been successfully applied in river flow and water level forecasting studies. ANN requires historical data to develop a forecasting model. However, long-term historical water level data, such as hourly data, poses two crucial problems in data training. First is that the high volume of data slows the computation process. Second is that data training reaches its optimal performance within a few cycles of data training, due to there being a high volume of normal water level data in the data training, while the forecasting performance for high water level events is still poor. In this study, the zoning matching approach (ZMA) is used in ANN to accurately monitor flood events in real time by focusing the development of the forecasting model on high water level zones. ZMA is a trial and error approach, where several training datasets using high water level data are tested to find the best training dataset for forecasting high water level events. The advantage of ZMA is that relevant knowledge of water level patterns in historical records is used. Importantly, the forecasting model developed based on ZMA successfully achieves high accuracy forecasting results at 1 to 3 h ahead and satisfactory performance results at 6 h. Seven performance measures are adopted in this study to describe the accuracy and reliability of the forecasting model developed.

Research of Academic Motivation at the Stage of Forming a Threshold Level of Mastering Competences

ERIC Educational Resources Information Center

Eremicheva, Oksana Y.; Yudin, Vladimir V.; Sheptukhina, Inna I.; Zyryanova, Natalia I.; Shevchenko, Valery Y.; Komarova, Yuliya G.; Simonova, Marina V.

2016-01-01

The relevance of the researched problem is caused by the society requirement to form and implement educational and creative potential of a student as a conductor of changes that set a high level of motivational behavior. The aim of this article is to develop a structural model of motivational behavior of students that allow carrying out modeling…

Airbreathing hypersonic vehicle design and analysis methods

NASA Technical Reports Server (NTRS)

Lockwood, Mary Kae; Petley, Dennis H.; Hunt, James L.; Martin, John G.

1996-01-01

The design, analysis, and optimization of airbreathing hypersonic vehicles requires analyses involving many highly coupled disciplines at levels of accuracy exceeding those traditionally considered in a conceptual or preliminary-level design. Discipline analysis methods including propulsion, structures, thermal management, geometry, aerodynamics, performance, synthesis, sizing, closure, and cost are discussed. Also, the on-going integration of these methods into a working environment, known as HOLIST, is described.

System-level view of geospace dynamics: Challenges for high-latitude ground-based observations

NASA Astrophysics Data System (ADS)

Donovan, E.

2014-12-01

Increasingly, research programs including GEM, CEDAR, GEMSIS, GO Canada, and others are focusing on how geospace works as a system. Coupling sits at the heart of system level dynamics. In all cases, coupling is accomplished via fundamental processes such as reconnection and plasma waves, and can be between regions, energy ranges, species, scales, and energy reservoirs. Three views of geospace are required to attack system level questions. First, we must observe the fundamental processes that accomplish the coupling. This "observatory view" requires in situ measurements by satellite-borne instruments or remote sensing from powerful well-instrumented ground-based observatories organized around, for example, Incoherent Scatter Radars. Second, we need to see how this coupling is controlled and what it accomplishes. This demands quantitative observations of the system elements that are being coupled. This "multi-scale view" is accomplished by networks of ground-based instruments, and by global imaging from space. Third, if we take geospace as a whole, the system is too complicated, so at the top level we need time series of simple quantities such as indices that capture important aspects of the system level dynamics. This requires a "key parameter view" that is typically provided through indices such as AE and DsT. With the launch of MMS, and ongoing missions such as THEMIS, Cluster, Swarm, RBSP, and ePOP, we are entering a-once-in-a-lifetime epoch with a remarkable fleet of satellites probing processes at key regions throughout geospace, so the observatory view is secure. With a few exceptions, our key parameter view provides what we need. The multi-scale view, however, is compromised by space/time scales that are important but under-sampled, combined extent of coverage and resolution that falls short of what we need, and inadequate conjugate observations. In this talk, I present an overview of what we need for taking system level research to its next level, and how high latitude ground based observations can address these challenges.

Sex hormones affect language lateralisation but not cognitive control in normally cycling women.

PubMed

Hodgetts, Sophie; Weis, Susanne; Hausmann, Markus

2015-08-01

This article is part of a Special Issue "Estradiol and Cognition". Natural fluctuations of sex hormones during the menstrual cycle have been shown to modulate language lateralisation. Using the dichotic listening (DL) paradigm, a well-established measurement of language lateralisation, several studies revealed that the left hemispheric language dominance was stronger when levels of estradiol were high. A recent study (Hjelmervik et al., 2012) showed, however, that high levels of follicular estradiol increased lateralisation only in a condition that required participants to cognitively control (top-down) the stimulus-driven (bottom-up) response. This finding suggested that sex hormones modulate lateralisation only if cognitive control demands are high. The present study investigated language lateralisation in 73 normally cycling women under three attention conditions that differed in cognitive control demands. Saliva estradiol and progesterone levels were determined by luminescence immunoassays. Women were allocated to a high or low estradiol group. The results showed a reduced language lateralisation when estradiol and progesterone levels were high. The effect was independent of the attention condition indicating that estradiol marginally affected cognitive control. The findings might suggest that high levels of estradiol especially reduce the stimulus-driven (bottom-up) aspect of lateralisation rather than top-down cognitive control. Copyright © 2015 Elsevier Inc. All rights reserved.

Contrasting Methods for Measuring Evapotranspiration in Soybean

USDA-ARS?s Scientific Manuscript database

Crop scientists are often interested in canopy rather than leaf water fluxes. Canopy measurements are difficult to obtain because instrumentation is expensive, investigations require a high level of comprehension in micrometeorological methods, and treatment comparisons are usually limited. The obje...

On the role of calcium in adrenocorticotropin-induced changes in mitochondrial pregnenolone synthesis.

PubMed

Farese, R V; Prudente, W J

1978-10-01

The importance of calcium in the ACTH-induced increase in adrenal mitochondrial pregnenolone synthesis was evaluated. In mitochondria prepared in the absence of EDTA and albumin, calcium enhanced the binding of cholesterol to cytochrome P-450 and subsequent pregnenolone synthesis. Although these effects of calcium were slightly greater in control than in ACTH-treated mitochondria, a sizeable effect of ACTH remained even at high calcium levels (500 micron). In mitochondria prepared from adrenals homogenized in fluid containing EDTA and albumin, ACTH-induced effects on pregnenolone synthesis were relatively poor unless calcium was added to the incubation mixture. High concentrations of added calcium (500 micron or greater) obviated the need for the labile protein required for ACTH-induced effects in intact mitochondria, presumably by disrupting mitochondria and allowing an "unrestrained" interaction of cholesterol with cytochrome P-450. Thus, cholesterol-rich mitochondria from ACTH plus cycloheximide-treated rats produced large amounts of pregnenolone when high (probably unphysiological) calcium concentrations were present. The present findings suggest that calcium is required at the mitochondrial level for ACTH-induced effects on pregnenolone synthesis, and the reported ACTH-induced increase in intraadrenal calcium may thus amplify the effects of ACTH on steroidogenesis. However, it seems unlikely that calcium is the agent primarily responsible for mediating the ACTH-induced steroidogenic effect at the mitochondrial level.

High-performance image processing on the desktop

NASA Astrophysics Data System (ADS)

Jordan, Stephen D.

1996-04-01

The suitability of computers to the task of medical image visualization for the purposes of primary diagnosis and treatment planning depends on three factors: speed, image quality, and price. To be widely accepted the technology must increase the efficiency of the diagnostic and planning processes. This requires processing and displaying medical images of various modalities in real-time, with accuracy and clarity, on an affordable system. Our approach to meeting this challenge began with market research to understand customer image processing needs. These needs were translated into system-level requirements, which in turn were used to determine which image processing functions should be implemented in hardware. The result is a computer architecture for 2D image processing that is both high-speed and cost-effective. The architectural solution is based on the high-performance PA-RISC workstation with an HCRX graphics accelerator. The image processing enhancements are incorporated into the image visualization accelerator (IVX) which attaches to the HCRX graphics subsystem. The IVX includes a custom VLSI chip which has a programmable convolver, a window/level mapper, and an interpolator supporting nearest-neighbor, bi-linear, and bi-cubic modes. This combination of features can be used to enable simultaneous convolution, pan, zoom, rotate, and window/level control into 1 k by 1 k by 16-bit medical images at 40 frames/second.

Electrochemical probing of high-level radioactive waste tanks containing washed sludge and precipitates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bickford, D.F.; Congdon, J.W.; Oblath, S.B.

1986-12-01

At the US Department of Energy's Savannah River Plant, corrosion of carbon steel storage tanks containing alkaline, high-level radioactive waste is controlled by specification of limits on waste composition and temperature. Processes for the preparation of waste for final disposal will result in waste with low corrosion inhibitor concentrations and, in some cases, high aromatic organic concentrations, neither of which are characteristic of previous operations. Laboratory tests, conducted to determine minimum corrosion inhibitor levels indicated pitting of carbon steel near the waterline for proposed storage conditions. In situ electrochemical measurements of full-scale radioactive process demonstrations have been conducted to assessmore » the validity of laboratory tests. Probes included pH, Eh (potential relative to a standard hydrogen electrode), tank potential, and alloy coupons. In situ results are compared to those of the laboratory tests, with particular regard given to simulated solution composition. Transition metal hydroxide sludge contains strong passivating species for carbon steel. Washed precipitate contains organic species that lower solution pH and tend to reduce passivating films, requiring higher inhibitor concentrations than the 0.01 molar nitrite required for reactor fuel reprocessing wastes. Periodic agitation, to keep the organic phase suspended, or cathodic protection are possible alternatives to higher nitrite inhibitor concentrations.« less

Use of the Rasch measurement model to explore the relationship between content knowledge and topic-specific pedagogical content knowledge for organic chemistry

NASA Astrophysics Data System (ADS)

Davidowitz, Bette; Potgieter, Marietjie

2016-06-01

Research has shown that a high level of content knowledge (CK) is necessary but not sufficient to develop the special knowledge base of expert teachers known as pedagogical content knowledge (PCK). This study contributes towards research to quantify the relationship between CK and PCK in science. In order to determine the proportion of the variance in PCK accounted for by the variance in CK, instruments are required which are valid and reliable as well as being unidimensional to measure person abilities for CK and PCK. An instrument consisting of two paper-and-pencil tests was designed to assess Grade 12 teachers CK and PCK in organic chemistry. We used the Rasch measurement model to convert raw score data into interval measures and to provide empirical evidence for the validity, reliability and unidimensionality of the tests. The correlation between CK and PCK was estimated as r = .66 (p < .001). We found evidence to suggest that while topic-specific PCK (TSPCK) develops with increasing teaching experience, high levels of CK can be acquired with limited teaching experience. These findings support the hypothesis that CK is a requirement for the development of TSPCK; proficiency in CK is, however, not necessarily associated with high levels of TSPCK.

Professional or administrative value patterns? Clinical pathways in medical problem-solving processes.

PubMed

Holmberg, Leif

2007-11-01

A health-care organization simultaneously belongs to two different institutional value patterns: a professional and an administrative value pattern. At the administrative level, medical problem-solving processes are generally perceived as the efficient application of familiar chains of activities to well-defined problems; and a low task uncertainty is therefore assumed at the work-floor level. This assumption is further reinforced through clinical pathways and other administrative guidelines. However, studies have shown that in clinical practice such administrative guidelines are often considered inadequate and difficult to implement mainly because physicians generally perceive task uncertainty to be high and that the guidelines do not cover the scope of encountered deviations. The current administrative level guidelines impose uniform structural features that meet the requirement for low task uncertainty. Within these structural constraints, physicians must organize medical problem-solving processes to meet any task uncertainty that may be encountered. Medical problem-solving processes with low task uncertainty need to be organized independently of processes with high task uncertainty. Each process must be evaluated according to different performance standards and needs to have autonomous administrative guideline models. Although clinical pathways seem appropriate when there is low task uncertainty, other kinds of guidelines are required when the task uncertainty is high.

Comparisons of false negative rates from a trend test alone and from a trend test jointly with a control-high groups pairwise test in the determination of the carcinogenicity of new drugs.

PubMed

Lin, Karl K; Rahman, Mohammad A

2018-05-21

Interest has been expressed in using a joint test procedure that requires that the results of both a trend test and a pairwise comparison test between the control and the high groups be statistically significant simultaneously at the levels of significance recommended in the FDA 2001 draft guidance for industry document for the separate tests in order for the drug effect on the development of an individual tumor type to be considered as statistically significant. Results of our simulation studies show that there is a serious consequence of large inflations of the false negative rate through large decreases of false positive rate in the use of the above joint test procedure in the final interpretation of the carcinogenicity potential of a new drug if the levels of significance recommended for separate tests are used. The inflation can be as high as 204.5% of the false negative rate when the trend test alone is required to test if the effect is statistically significant. To correct the problem, new sets of levels of significance have also been developed for those who want to use the joint test in reviews of carcinogenicity studies.

Research on performance requirements of turbofan engine used on carrier-based UAV

NASA Astrophysics Data System (ADS)

Zhao, Shufan; Li, Benwei; Zhang, Wenlong; Wu, Heng; Feng, Tang

2017-05-01

According to the mission requirements of the carrier-based unmanned aerial vehicle (UAV), a mode level flight was established to calculate the thrust requirements from altitude 9 km to 13 km. Then, the estimation method of flight profile was used to calculate the weight of UAV in each stage to get the specific fuel consumption requirements of the UAV in standby stage. The turbofan engine of carrier-based UAV should meet the thrust and specific fuel consumption requirements. Finally, the GSP software was used to verify the simulation of a small high-bypass turbofan engine. The conclusion is useful for the turbofan engine selection of carrier-based UAV.

HALE UAS Command and Control Communications: Step 1 - Functional Requirements Document. Version 4.0

NASA Technical Reports Server (NTRS)

2006-01-01

The High Altitude Long Endurance (HALE) unmanned aircraft system (UAS) communicates with an off-board pilot-in-command in all flight phases via the C2 data link, making it a critical component for the UA to fly in the NAS safely and routinely. This is a new requirement in current FAA communications planning and monitoring processes. This document provides a set of comprehensive C2 communications functional requirements and performance guidelines to help facilitate the future FAA certification process for civil UAS to operate in the NAS. The objective of the guidelines is to provide the ability to validate the functional requirements and in future be used to develop performance-level requirements.

The SCARLET{trademark} array for high power GEO satellites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spence, B.R.; Jones, P.A.; Eskenazi, M.I.

1997-12-31

The GEO satellite market is demanding increasingly capable spacecraft which, in turn, drives commercial spacecraft manufacturers to require significantly higher power solar arrays. As satellite capability increases the demand for high power array systems which are both cost and performance competitive becomes more crucial. Conventional rigid panel planar arrays, although suitable in the past, negatively impact spacecraft competitiveness for these new applications. The Solar Concentrator Array with Refractive Linear Element Technology (SCARLET{trademark}) represents an economically attractive solution for meeting these new high power requirements. When compared to conventional planar arrays, SCARLET provides substantially lower cost and higher deployed stiffness, competitivemore » mass, better producibility, and affordable use of high efficiency multijunction cells. This paper compares cost/performance characteristics of the SCARLET array to conventional planar arrays for high power GEO spacecraft applications. High power SCARLET array configurations are described, and inherent spacecraft and array level cost/performance benefits are presented.« less

Model and algorithmic framework for detection and correction of cognitive errors.

PubMed

Feki, Mohamed Ali; Biswas, Jit; Tolstikov, Andrei

2009-01-01

This paper outlines an approach that we are taking for elder-care applications in the smart home, involving cognitive errors and their compensation. Our approach involves high level modeling of daily activities of the elderly by breaking down these activities into smaller units, which can then be automatically recognized at a low level by collections of sensors placed in the homes of the elderly. This separation allows us to employ plan recognition algorithms and systems at a high level, while developing stand-alone activity recognition algorithms and systems at a low level. It also allows the mixing and matching of multi-modality sensors of various kinds that go to support the same high level requirement. Currently our plan recognition algorithms are still at a conceptual stage, whereas a number of low level activity recognition algorithms and systems have been developed. Herein we present our model for plan recognition, providing a brief survey of the background literature. We also present some concrete results that we have achieved for activity recognition, emphasizing how these results are incorporated into the overall plan recognition system.

HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.

PubMed

Khomtchouk, Bohdan B; Van Booven, Derek J; Wahlestedt, Claes

2014-01-01

The graphical visualization of gene expression data using heatmaps has become an integral component of modern-day medical research. Heatmaps are used extensively to plot quantitative differences in gene expression levels, such as those measured with RNAseq and microarray experiments, to provide qualitative large-scale views of the transcriptonomic landscape. Creating high-quality heatmaps is a computationally intensive task, often requiring considerable programming experience, particularly for customizing features to a specific dataset at hand. Software to create publication-quality heatmaps is developed with the R programming language, C++ programming language, and OpenGL application programming interface (API) to create industry-grade high performance graphics. We create a graphical user interface (GUI) software package called HeatmapGenerator for Windows OS and Mac OS X as an intuitive, user-friendly alternative to researchers with minimal prior coding experience to allow them to create publication-quality heatmaps using R graphics without sacrificing their desired level of customization. The simplicity of HeatmapGenerator is that it only requires the user to upload a preformatted input file and download the publicly available R software language, among a few other operating system-specific requirements. Advanced features such as color, text labels, scaling, legend construction, and even database storage can be easily customized with no prior programming knowledge. We provide an intuitive and user-friendly software package, HeatmapGenerator, to create high-quality, customizable heatmaps generated using the high-resolution color graphics capabilities of R. The software is available for Microsoft Windows and Apple Mac OS X. HeatmapGenerator is released under the GNU General Public License and publicly available at: http://sourceforge.net/projects/heatmapgenerator/. The Mac OS X direct download is available at: http://sourceforge.net/projects/heatmapgenerator/files/HeatmapGenerator_MAC_OSX.tar.gz/download. The Windows OS direct download is available at: http://sourceforge.net/projects/heatmapgenerator/files/HeatmapGenerator_WINDOWS.zip/download.

Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells.

PubMed

Hancock, Meaghan H; Cliffe, Anna R; Knipe, David M; Smiley, James R

2010-02-01

The herpes simplex virus (HSV) genome rapidly becomes associated with histones after injection into the host cell nucleus. The viral proteins ICP0 and VP16 are required for efficient viral gene expression and have been implicated in reducing the levels of underacetylated histones on the viral genome, raising the possibility that high levels of underacetylated histones inhibit viral gene expression. The U2OS osteosarcoma cell line is permissive for replication of ICP0 and VP16 mutants and appears to lack an innate antiviral repression mechanism present in other cell types. We therefore used chromatin immunoprecipitation to determine whether U2OS cells are competent to load histones onto HSV DNA and, if so, whether ICP0 and/or VP16 are required to reduce histone occupancy and enhance acetylation in this cell type. High levels of underacetylated histone H3 accumulated at several locations on the viral genome in the absence of VP16 activation function; in contrast, an ICP0 mutant displayed markedly reduced histone levels and enhanced acetylation, similar to wild-type HSV. These results demonstrate that U2OS cells are competent to load underacetylated histones onto HSV DNA and uncover an unexpected role for VP16 in modulating chromatin structure at viral early and late loci. One interpretation of these findings is that ICP0 and VP16 affect viral chromatin structure through separate pathways, and the pathway targeted by ICP0 is defective in U2OS cells. We also show that HSV infection results in decreased histone levels on some actively transcribed genes within the cellular genome, demonstrating that viral infection alters cellular chromatin structure.

Herpes Simplex Virus VP16, but Not ICP0, Is Required To Reduce Histone Occupancy and Enhance Histone Acetylation on Viral Genomes in U2OS Osteosarcoma Cells▿ †

PubMed Central

Hancock, Meaghan H.; Cliffe, Anna R.; Knipe, David M.; Smiley, James R.

2010-01-01

The herpes simplex virus (HSV) genome rapidly becomes associated with histones after injection into the host cell nucleus. The viral proteins ICP0 and VP16 are required for efficient viral gene expression and have been implicated in reducing the levels of underacetylated histones on the viral genome, raising the possibility that high levels of underacetylated histones inhibit viral gene expression. The U2OS osteosarcoma cell line is permissive for replication of ICP0 and VP16 mutants and appears to lack an innate antiviral repression mechanism present in other cell types. We therefore used chromatin immunoprecipitation to determine whether U2OS cells are competent to load histones onto HSV DNA and, if so, whether ICP0 and/or VP16 are required to reduce histone occupancy and enhance acetylation in this cell type. High levels of underacetylated histone H3 accumulated at several locations on the viral genome in the absence of VP16 activation function; in contrast, an ICP0 mutant displayed markedly reduced histone levels and enhanced acetylation, similar to wild-type HSV. These results demonstrate that U2OS cells are competent to load underacetylated histones onto HSV DNA and uncover an unexpected role for VP16 in modulating chromatin structure at viral early and late loci. One interpretation of these findings is that ICP0 and VP16 affect viral chromatin structure through separate pathways, and the pathway targeted by ICP0 is defective in U2OS cells. We also show that HSV infection results in decreased histone levels on some actively transcribed genes within the cellular genome, demonstrating that viral infection alters cellular chromatin structure. PMID:19939931

Generic functional requirements for a NASA general-purpose data base management system

NASA Technical Reports Server (NTRS)

Lohman, G. M.

1981-01-01

Generic functional requirements for a general-purpose, multi-mission data base management system (DBMS) for application to remotely sensed scientific data bases are detailed. The motivation for utilizing DBMS technology in this environment is explained. The major requirements include: (1) a DBMS for scientific observational data; (2) a multi-mission capability; (3) user-friendly; (4) extensive and integrated information about data; (5) robust languages for defining data structures and formats; (6) scientific data types and structures; (7) flexible physical access mechanisms; (8) ways of representing spatial relationships; (9) a high level nonprocedural interactive query and data manipulation language; (10) data base maintenance utilities; (11) high rate input/output and large data volume storage; and adaptability to a distributed data base and/or data base machine configuration. Detailed functions are specified in a top-down hierarchic fashion. Implementation, performance, and support requirements are also given.

Evaluation of the impact of noise metrics on tiltrotor aircraft design

NASA Technical Reports Server (NTRS)

Sternfeld, H.; Spencer, R.; Ziegenbein, P.

1995-01-01

A subjective noise evaluation was conducted in which the test participants evaluated the annoyance of simulated sounds representative of future civil tiltrotor aircraft. The subjective responses were correlated with the noise metrics of A-weighted sound pressure level, overall sound pressure level, and perceived level. The results indicated that correlation between subjective response and A-weighted sound pressure level is considerably enhanced by combining it in a multiple regression with overall sound pressure level. As a single metric, perceived level correlated better than A-weighted sound pressure level due to greater emphasis on low frequency noise components. This latter finding was especially true for indoor noise where the mid and high frequency noise components are attenuated by typical building structure. Using the results of the subjective noise evaluation, the impact on tiltrotor aircraft design was also evaluated. While A-weighted sound pressure level can be reduced by reduction in tip speed, an increase in number of rotor blades is required to achieve significant reduction of low frequency noise as measured by overall sound pressure level. Additional research, however, is required to achieve comparable reductions in impulsive noise due to blade-vortex interaction, and also to achieve reduction in broad band noise.

Simulation Data Management - Requirements and Design Specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clay, Robert L.; Friedman-Hill, Ernest J.; Gibson, Marcus J.

Simulation Data Management (SDM), the ability to securely organize, archive, and share analysis models and the artifacts used to create them, is a fundamental requirement for modern engineering analysis based on computational simulation. We have worked separately to provide secure, network SDM services to engineers and scientists at our respective laboratories for over a decade. We propose to leverage our experience and lessons learned to help develop and deploy a next-generation SDM service as part of a multi-laboratory team. This service will be portable across multiple sites and platforms, and will be accessible via a range of command-line tools andmore » well-documented APIs. In this document, we’ll review our high-level and low-level requirements for such a system, review one existing system, and briefly discuss our proposed implementation.« less

Behavioral and biological interactions with small groups in confined microsocieties

NASA Technical Reports Server (NTRS)

Brady, J. V.; Emurian, H. H.

1982-01-01

Requirements for high levels of human performance in the unfamiliar and stressful environments associated with space missions necessitate the development of research-based technological procedures for maximizing the probability of effective functioning at all levels of personnel participation. Where the successful accomplishment of such missions requires the coordinated contributions of several individuals collectively identified with the achievement of a common objective, the conditions for characterizing a team, crew, or functional group are operationally defined. For the most part, studies of group performances under operational conditions which emphasize relatively long exposure to extended mission environments have been limited by the constraints imposed on experimental manipulations to identify critical effectiveness factors. On the other hand, laboratory studies involving relatively brief exposures to contrived task situations have been considered of questionable generality to operational settings requiring realistic group objectives.

Regulation of COL1A1 expression in type I collagen producing tissues: identification of a 49 base pair region which is required for transgene expression in bone of transgenic mice

NASA Technical Reports Server (NTRS)

Bedalov, A.; Salvatori, R.; Dodig, M.; Kronenberg, M. S.; Kapural, B.; Bogdanovic, Z.; Kream, B. E.; Woody, C. O.; Clark, S. H.; Mack, K.;

A game theory based framework for assessing incentives for local area collaboration with an application to Scottish salmon farming.

PubMed

Murray, Alexander G

2014-08-01

Movements of water that transport pathogens mean that in net-pen aquaculture diseases are often most effectively managed collaboratively among neighbours. Such area management is widely and explicitly applied for pathogen management in marine salmon farms. Effective area management requires the active support of farm managers and a simple game-theory based framework was developed to identify the conditions required under which collaboration is perceived to be in their own best interest. The model applied is based on area management as practiced for Scottish salmon farms, but its simplicity allows it to be generalised to other area-managed net-pen aquaculture systems. In this model managers choose between purchasing tested pathogen-free fish or cheaper, untested fish that might carry pathogens. Perceived pay-off depends on degree of confidence that neighbours will not buy untested fish, risking input of pathogens that spread between farms. For a given level of risk, confidence in neighbours is most important in control of moderate-impact moderate-probability diseases. Common low-impact diseases require high confidence since there is a high probability a neighbour will import, while testing for rare high-impact diseases may be cost-effective regardless of neighbours actions. In some cases testing may be beneficial at an area level, even if all individual farms are better off not testing. Higher confidence is required for areas with many farms and so focusing management on smaller, epidemiologically imperfect, areas may be more effective. The confidence required for collaboration can be enhanced by the development of formal agreements and the involvement of outside disinterested parties such as trade bodies or government. Copyright © 2014. Published by Elsevier B.V.

Magnetic Fields on the National Ignition Facility (MagNIF)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mason, D.; Folta, J.

2016-08-12

A magnetized target capability on the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) has been investigated. Stakeholders’ needs and project feasibility analysis were considered in order to down-select from a wide variety of different potential magnetic field magnitudes and volumes. From the large range of different target platforms, laser configurations, and diagnostics configurations of interest to the stakeholders, the gas-pipe platform has been selected for the first round of magnetized target experiments. Gas pipe targets are routinely shot on the NIF and provide unique value for external collaborators. High-level project goals have been established including an experimentallymore » relevant 20Tesla magnetic field magnitude. The field will be achieved using pulsed power-driven coils. A system architecture has been proposed. The pulsed power drive system will be located in the NIF target bay. This decision provides improved maintainability and mitigates equipment safety risks associated with explosive failure of the drive capacitor. High-level and first-level subsystem requirements have been established. Requirements have been included for two distinct coil designs – full solenoid and quasi-Helmholtz. A Failure Modes and Effects Analysis (FMEA) has been performed and documented. Additional requirements have been derived from the mitigations included in the FMEA document. A project plan is proposed. The plan includes a first phase of electromagnetic simulations to assess whether the design will meet performance requirements, then a second phase of risk mitigation projects to address the areas of highest technical risk. The duration from project kickoff to the first magnetized target shot is approximately 29 months.« less

Advances in DNA sequencing technologies for high resolution HLA typing.

PubMed

Cereb, Nezih; Kim, Hwa Ran; Ryu, Jaejun; Yang, Soo Young

2015-12-01

This communication describes our experience in large-scale G group-level high resolution HLA typing using three different DNA sequencing platforms - ABI 3730 xl, Illumina MiSeq and PacBio RS II. Recent advances in DNA sequencing technologies, so-called next generation sequencing (NGS), have brought breakthroughs in deciphering the genetic information in all living species at a large scale and at an affordable level. The NGS DNA indexing system allows sequencing multiple genes for large number of individuals in a single run. Our laboratory has adopted and used these technologies for HLA molecular testing services. We found that each sequencing technology has its own strengths and weaknesses, and their sequencing performances complement each other. HLA genes are highly complex and genotyping them is quite challenging. Using these three sequencing platforms, we were able to meet all requirements for G group-level high resolution and high volume HLA typing. Copyright © 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.