Publication of the maps of Tenke and Manono (Zaire) from LANDSAT data

NASA Technical Reports Server (NTRS)

Yampania, M.

1981-01-01

The collection of cartographic data on Zaire up to the present time was based on aerial reconnaissance. This approach is very expensive if repetitive coverage is required in such a large country. The integration with the LANDSAT program among the data collection systems improves the mapping efforts substantially.

HOW TO WRITE A SCIENTIFIC ARTICLE

PubMed Central

Manske, Robert C.

2012-01-01

Successful production of a written product for submission to a peer‐reviewed scientific journal requires substantial effort. Such an effort can be maximized by following a few simple suggestions when composing/creating the product for submission. By following some suggested guidelines and avoiding common errors, the process can be streamlined and success realized for even beginning/novice authors as they negotiate the publication process. The purpose of this invited commentary is to offer practical suggestions for achieving success when writing and submitting manuscripts to The International Journal of Sports Physical Therapy and other professional journals. PMID:23091783

The deep web, dark matter, metabundles and the broadband elites: do you need an informaticist?

PubMed

Holden, Gary; Rosenberg, Gary

2003-01-01

The World Wide Web (WWW) is growing in size and is becoming a substantial component of life. This seems especially true for US professionals, including social workers. It will require effort by these professionals to use the WWW effectively and efficiently. One of the main issues that these professionals will encounter in these efforts is the quality of materials located on the WWW. This paper reviews some of the factors related to improving the quality of information obtained from the WWW by social workers.

Effects of repeated burning on snag abundance in shortleaf pine woodlands

Treesearch

Roger W. Perry; Phillip N. Jordan; Virginia L. McDaniel

2017-01-01

Forest managers are restoring and maintaining forest woodlands across substantial areas of the United States, and these efforts typically require the use of frequent prescribed fire. The effects of frequent prescribed fire on important habitat components such as snags remain unknown. We conducted a study to determine how snag densities are affected by repeated...

Early detection monitoring for larval dreissenid mussels: How much plankton sampling is enough?

USGS Publications Warehouse

Counihan, Timothy D.; Bollens, Stephen M.

2017-01-01

The development of quagga and zebra mussel (dreissenids) monitoring programs in the Pacific Northwest provides a unique opportunity to evaluate a regional invasive species detection effort early in its development. Recent studies suggest that the ecological and economic costs of a dreissenid infestation in the Pacific Northwest of the USA would be significant. Consequently, efforts are underway to monitor for the presence of dreissenids. However, assessments of whether these efforts provide for early detection are lacking. We use information collected from 2012 to 2014 to characterize the development of larval dreissenid monitoring programs in the states of Idaho, Montana, Oregon, and Washington in the context of introduction and establishment risk. We also estimate the effort needed for high-probability detection of rare planktonic taxa in four Columbia and Snake River reservoirs and assess whether the current level of effort provides for early detection. We found that the effort expended to monitor for dreissenid mussels increased substantially from 2012 to 2014, that efforts were distributed across risk categories ranging from high to very low, and that substantial gaps in our knowledge of both introduction and establishment risk exist. The estimated volume of filtered water required to fully census planktonic taxa or to provide high-probability detection of rare taxa was high for the four reservoirs examined. We conclude that the current level of effort expended does not provide for high-probability detection of larval dreissenids or other planktonic taxa when they are rare in these reservoirs. We discuss options to improve early detection capabilities.

Methods and Protocols for Developing Prion Vaccines.

PubMed

Marciniuk, Kristen; Taschuk, Ryan; Napper, Scott

2016-01-01

Prion diseases denote a distinct form of infectivity that is based in the misfolding of a self-protein (PrP(C)) into a pathological, infectious conformation (PrP(Sc)). Efforts to develop vaccines for prion diseases have been complicated by the potential dangers that are associated with induction of immune responses against a self-protein. As a consequence, there is considerable appeal for vaccines that specifically target the misfolded prion conformation. Such conformation-specific immunotherapy is made possible through the identification of vaccine targets (epitopes) that are exclusively presented as a consequence of misfolding. An immune response directed against these targets, termed disease-specific epitopes (DSEs), has the potential to spare the function of the native form of the protein while clearing, or neutralizing, the infectious isomer. Although identification of DSEs represents a critical first step in the induction of conformation-specific immune responses, substantial efforts are required to translate these targets into functional vaccines. Due to the poor immunogenicity that is inherent to self-proteins, and that is often associated with short peptides, substantial efforts are required to overcome tolerance-to-self and maximize the resultant immune response following DSE-based immunization. This often includes optimization of target sequences in terms of immunogenicity and development of effective formulation and delivery strategies for the associated peptides. Further, these vaccines must satisfy additional criteria from perspectives of specificity (PrP(C) vs. PrP(Sc)) and safety (antibody-induced template-driven misfolding of PrP(C)). The emphasis of this report is on the steps required to translate DSEs into prion vaccines and subsequent evaluation of the resulting immune responses.

Prefrontal Cortical Inactivations Decrease Willingness to Expend Cognitive Effort on a Rodent Cost/Benefit Decision-Making Task.

PubMed

Hosking, Jay G; Cocker, Paul J; Winstanley, Catharine A

2016-04-01

Personal success often necessitates expending greater effort for greater reward but, equally important, also requires judicious use of our limited cognitive resources (e.g., attention). Previous animal models have shown that the prelimbic (PL) and infralimbic (IL) regions of the prefrontal cortex (PFC) are not involved in (physical) effort-based choice, whereas human studies have demonstrated PFC contributions to (mental) effort. Here, we utilize the rat Cognitive Effort Task (rCET) to probe PFC's role in effort-based decision making. In the rCET, animals can choose either an easy trial, where the attentional demand is low but the reward (sugar) is small or a difficult trial on which both the attentional demand and reward are greater. Temporary inactivation of PL and IL decreased all animals' willingness to expend mental effort and increased animals' distractibility; PL inactivations more substantially affected performance (i.e., attention), whereas IL inactivations increased motor impulsivity. These data imply that the PFC contributes to attentional resources, and when these resources are diminished, animals shift their choice (via other brain regions) accordingly. Thus, one novel therapeutic approach to deficits in effort expenditure may be to focus on the resources that such decision making requires, rather than the decision-making process per se. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Helping effort increases with relatedness in bell miners, but ‘unrelated’ helpers of both sexes still provide substantial care

PubMed Central

Wright, Jonathan; McDonald, Paul G.; te Marvelde, Luc; Kazem, Anahita J. N.; Bishop, Charles M.

2010-01-01

Indirect fitness benefits from kin selection can explain why non-breeding individuals help raise the young of relatives. However, the evolution of helping by non-relatives requires direct fitness benefits, for example via group augmentation. Here, we examine nest visit rates, load sizes and prey types delivered by breeding pairs and their helpers in the cooperatively breeding bell miner (Manorina melanophrys). In this system, males remain in their natal colony while young females typically disperse, and helpers of both sexes often assist at multiple nests concurrently. We found extremely clear evidence for the expected effect of genetic relatedness on individual helping effort per nest within colonies. This positive incremental effect of kinship was facultative—i.e. largely the result of within-individual variation in helping effort. Surprisingly, no sex differences were detectable in any aspect of helping, and even non-relatives provided substantial aid. Helpers and breeders of both sexes regulated their provisioning effort by responding visit-by-visit to changes in nestling begging. Helping behaviour in bell miners therefore appears consistent with adaptive cooperative investment in the brood, and kin-selected care by relatives. Similar investment by ‘unrelated’ helpers of both sexes argues against direct fitness benefits, but is perhaps explained by kin selection at the colony level. PMID:19846458

The Behavioral Pharmacology of Effort-related Choice Behavior: Dopamine, Adenosine and Beyond

PubMed Central

Salamone, John D; Correa, Merce; Nunes, Eric J; Randall, Patrick A; Pardo, Marta

2012-01-01

For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic DA are undergoing a substantial conceptual restructuring, with the traditional emphasis on hedonia and primary reward yielding to other concepts and lines of inquiry. The present review is focused upon the involvement of nucleus accumbens DA in effort-related choice behavior. Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA-depleted rats show a heightened sensitivity to response costs, especially ratio requirements. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related choice behavior. Rats with accumbens DA depletions or antagonism reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and show increased selection of low reinforcement/low cost options. Nucleus accumbens DA and adenosine interact in the regulation of effort-related functions, and other brain structures (anterior cingulate cortex, amygdala, ventral pallidum) also are involved. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as symptoms such as psychomotor slowing, fatigue or anergia in depression and other neurological disorders. PMID:22287808

The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond.

PubMed

Salamone, John D; Correa, Merce; Nunes, Eric J; Randall, Patrick A; Pardo, Marta

2012-01-01

For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the "rewarding" impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic DA are undergoing a substantial conceptual restructuring, with the traditional emphasis on hedonia and primary reward yielding to other concepts and lines of inquiry. The present review is focused upon the involvement of nucleus accumbens DA in effort-related choice behavior. Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA-depleted rats show a heightened sensitivity to response costs, especially ratio requirements. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related choice behavior. Rats with accumbens DA depletions or antagonism reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and show increased selection of low reinforcement/low cost options. Nucleus accumbens DA and adenosine interact in the regulation of effort-related functions, and other brain structures (anterior cingulate cortex, amygdala, ventral pallidum) also are involved. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as symptoms such as psychomotor slowing, fatigue or anergia in depression and other neurological disorders.

Options for a lunar base surface architecture

NASA Technical Reports Server (NTRS)

Roberts, Barney B.

1992-01-01

The Planet Surface Systems Office at the NASA Johnson Space Center has participated in an analysis of the Space Exploration Initiative architectures described in the Synthesis Group report. This effort involves a Systems Engineering and Integration effort to define point designs for evolving lunar and Mars bases that support substantial science, exploration, and resource production objectives. The analysis addresses systems-level designs; element requirements and conceptual designs; assessments of precursor and technology needs; and overall programmatics and schedules. This paper focuses on the results of the study of the Space Resource Utilization Architecture. This architecture develops the capability to extract useful materials from the indigenous resources of the Moon and Mars. On the Moon, a substantial infrastructure is emplaced which can support a crew of up to twelve. Two major process lines are developed: one produces oxygen, ceramics, and metals; the other produces hydrogen, helium, and other volatiles. The Moon is also used for a simulation of a Mars mission. Significant science capabilities are established in conjunction with resource development. Exploration includes remote global surveys and piloted sorties of local and regional areas. Science accommodations include planetary science, astronomy, and biomedical research. Greenhouses are established to provide a substantial amount of food needs.

Test Results for Entry Guidance Methods for Space Vehicles

NASA Technical Reports Server (NTRS)

Hanson, John M.; Jones, Robert E.

2004-01-01

There are a number of approaches to advanced guidance and control that have the potential for achieving the goals of significantly increasing reusable launch vehicle (or any space vehicle that enters an atmosphere) safety and reliability, and reducing the cost. This paper examines some approaches to entry guidance. An effort called Integration and Testing of Advanced Guidance and Control Technologies has recently completed a rigorous testing phase where these algorithms faced high-fidelity vehicle models and were required to perform a variety of representative tests. The algorithm developers spent substantial effort improving the algorithm performance in the testing. This paper lists the test cases used to demonstrate that the desired results are achieved, shows an automated test scoring method that greatly reduces the evaluation effort required, and displays results of the tests. Results show a significant improvement over previous guidance approaches. The two best-scoring algorithm approaches show roughly equivalent results and are ready to be applied to future vehicle concepts.

Test Results for Entry Guidance Methods for Reusable Launch Vehicles

NASA Technical Reports Server (NTRS)

Hanson, John M.; Jones, Robert E.

2003-01-01

There are a number of approaches to advanced guidance and control (AG&C) that have the potential for achieving the goals of significantly increasing reusable launch vehicle (RLV) safety and reliability, and reducing the cost. This paper examines some approaches to entry guidance. An effort called Integration and Testing of Advanced Guidance and Control Technologies (ITAGCT) has recently completed a rigorous testing phase where these algorithms faced high-fidelity vehicle models and were required to perform a variety of representative tests. The algorithm developers spent substantial effort improving the algorithm performance in the testing. This paper lists the test cases used to demonstrate that the desired results are achieved, shows an automated test scoring method that greatly reduces the evaluation effort required, and displays results of the tests. Results show a significant improvement over previous guidance approaches. The two best-scoring algorithm approaches show roughly equivalent results and are ready to be applied to future reusable vehicle concepts.

PharmTeX: a LaTeX-Based Open-Source Platform for Automated Reporting Workflow.

PubMed

Rasmussen, Christian Hove; Smith, Mike K; Ito, Kaori; Sundararajan, Vijayakumar; Magnusson, Mats O; Niclas Jonsson, E; Fostvedt, Luke; Burger, Paula; McFadyen, Lynn; Tensfeldt, Thomas G; Nicholas, Timothy

2018-03-16

Every year, the pharmaceutical industry generates a large number of scientific reports related to drug research, development, and regulatory submissions. Many of these reports are created using text processing tools such as Microsoft Word. Given the large number of figures, tables, references, and other elements, this is often a tedious task involving hours of copying and pasting and substantial efforts in quality control (QC). In the present article, we present the LaTeX-based open-source reporting platform, PharmTeX, a community-based effort to make reporting simple, reproducible, and user-friendly. The PharmTeX creators put a substantial effort into simplifying the sometimes complex elements of LaTeX into user-friendly functions that rely on advanced LaTeX and Perl code running in the background. Using this setup makes LaTeX much more accessible for users with no prior LaTeX experience. A software collection was compiled for users not wanting to manually install the required software components. The PharmTeX templates allow for inclusion of tables directly from mathematical software output as well and figures from several formats. Code listings can be included directly from source. No previous experience and only a few hours of training are required to start writing reports using PharmTeX. PharmTeX significantly reduces the time required for creating a scientific report fully compliant with regulatory and industry expectations. QC is made much simpler, since there is a direct link between analysis output and report input. PharmTeX makes available to report authors the strengths of LaTeX document processing without the need for extensive training. Graphical Abstract ᅟ.

The Relationship between Gross Motor Skills and School Readiness in Early Childhood: Making the Case in South Africa

ERIC Educational Resources Information Center

Sherry, Kate; Draper, Catherine E.

2013-01-01

Early childhood development (ECD) has gained substantial recognition in South Africa (SA) as a key issue to be addressed, but inequities and deficits remain evident, despite progressive policy and widespread effort by a range of role players in the non-governmental sector. ECD in SA requires far more attention if these are to be rectified, and…

A database for propagation models

NASA Technical Reports Server (NTRS)

Kantak, Anil V.; Suwitra, Krisjani; Le, Choung

1993-01-01

The NASA Propagation Program supports academic research that models various propagation phenomena in the space research frequency bands. NASA supports such research via school and institutions prominent in the field. The products of such efforts are particularly useful for researchers in the field of propagation phenomena and telecommunications systems engineers. The systems engineer usually needs a few propagation parameter values for a system design. Published literature on the subject, such as the Cunsultative Committee for International Radio (CCIR) publications, may help somewhat, but often times, the parameter values given in such publications use a particular set of conditions which may not quite include the requirements of the system design. The systems engineer must resort to programming the propagation phenomena model of interest and to obtain the parameter values to be used in the project. Furthermore, the researcher in the propagation field must then program the propagation models either to substantiate the model or to generate a new model. The researcher or the systems engineer must either be a skillful computer programmer or hire a programmer, which of course increases the cost of the effort. An increase in cost due to the inevitable programming effort may seem particularly inappropriate if the data generated by the experiment is to be used to substantiate the already well-established models, or a slight variation thereof. To help researchers and the systems engineers, it was recommended by the participants of NASA Propagation Experimenters (NAPEX) 15 held in London, Ontario, Canada on 28-29 June 1991, that propagation software should be constructed which will contain models and prediction methods of most propagation phenomenon. Moreover, the software should be flexible enough for the user to make slight changes to the models without expending a substantial effort in programming.

Terrestrial Planet Finder: Technology Development Plans

NASA Technical Reports Server (NTRS)

Lindensmith, Chris

2004-01-01

One of humanity's oldest questions is whether life exists elsewhere in the universe. The Terrestrial Planet Finder (TPF) mission will survey stars in our stellar neighborhood to search for planets and perform spectroscopic measurements to identify potential biomarkers in their atmospheres. In response to the recently published President's Plan for Space Exploration, TPF has plans to launch a visible-light coronagraph in 2014, and a separated-spacecraft infrared interferometer in 2016. Substantial funding has been committed to the development of the key technologies that are required to meet these goals for launch in the next decade. Efforts underway through industry and university contracts and at JPL include a number of system and subsystem testbeds, as well as components and numerical modeling capabilities. The science, technology, and design efforts are closely coupled to ensure that requirements and capabilities will be consistent and meet the science goals.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reisman, D.J.

A variety of issues must be addressed in development of software for information resources. One is accessibility and use of information. Another is that to properly design, abstract, index, and do quality control on a database requires the effort of well-trained and knowledgeable personnel as well as substantial financial resources. Transferring data to other locations has inherent difficulties, including those related to incompatibility. The main issue in developing health risk assessment databases is the needs of the user.

Novel Therapy for Bone Regeneration in Large Segmental Defects

DTIC Science & Technology

2014-10-01

for post-operative animal care. The time, effort, and even drugs required ( pain management) for post-operative management of minipigs has been...substantially larger than was anticipated. The veterinarian is still finalizing the post-operative pain management protocol as with each surgery he is...assessment/management. By Monday morning the veterinarian usually reduces the pain scoring and pain medications to twice a day. This of course does

Experiences with Text Mining Large Collections of Unstructured Systems Development Artifacts at JPL

NASA Technical Reports Server (NTRS)

Port, Dan; Nikora, Allen; Hihn, Jairus; Huang, LiGuo

2011-01-01

Often repositories of systems engineering artifacts at NASA's Jet Propulsion Laboratory (JPL) are so large and poorly structured that they have outgrown our capability to effectively manually process their contents to extract useful information. Sophisticated text mining methods and tools seem a quick, low-effort approach to automating our limited manual efforts. Our experiences of exploring such methods mainly in three areas including historical risk analysis, defect identification based on requirements analysis, and over-time analysis of system anomalies at JPL, have shown that obtaining useful results requires substantial unanticipated efforts - from preprocessing the data to transforming the output for practical applications. We have not observed any quick 'wins' or realized benefit from short-term effort avoidance through automation in this area. Surprisingly we have realized a number of unexpected long-term benefits from the process of applying text mining to our repositories. This paper elaborates some of these benefits and our important lessons learned from the process of preparing and applying text mining to large unstructured system artifacts at JPL aiming to benefit future TM applications in similar problem domains and also in hope for being extended to broader areas of applications.

14 CFR 16.21 - Pre-complaint resolution.

Code of Federal Regulations, 2010 CFR

2010-01-01

... complaint certifies that substantial and reasonable good faith efforts to resolve the disputed matter... person directly and substantially affected by the alleged noncompliance shall initiate and engage in good faith efforts to resolve the disputed matter informally with those individuals or entities believed...

Formal Analysis of the Remote Agent Before and After Flight

NASA Technical Reports Server (NTRS)

Havelund, Klaus; Lowry, Mike; Park, SeungJoon; Pecheur, Charles; Penix, John; Visser, Willem; White, Jon L.

2000-01-01

This paper describes two separate efforts that used the SPIN model checker to verify deep space autonomy flight software. The first effort occurred at the beginning of a spiral development process and found five concurrency errors early in the design cycle that the developers acknowledge would not have been found through testing. This effort required a substantial manual modeling effort involving both abstraction and translation from the prototype LISP code to the PROMELA language used by SPIN. This experience and others led to research to address the gap between formal method tools and the development cycle used by software developers. The Java PathFinder tool which directly translates from Java to PROMELA was developed as part of this research, as well as automatic abstraction tools. In 1999 the flight software flew on a space mission, and a deadlock occurred in a sibling subsystem to the one which was the focus of the first verification effort. A second quick-response "cleanroom" verification effort found the concurrency error in a short amount of time. The error was isomorphic to one of the concurrency errors found during the first verification effort. The paper demonstrates that formal methods tools can find concurrency errors that indeed lead to loss of spacecraft functions, even for the complex software required for autonomy. Second, it describes progress in automatic translation and abstraction that eventually will enable formal methods tools to be inserted directly into the aerospace software development cycle.

Visual cues and listening effort: individual variability.

PubMed

Picou, Erin M; Ricketts, Todd A; Hornsby, Benjamin W Y

2011-10-01

To investigate the effect of visual cues on listening effort as well as whether predictive variables such as working memory capacity (WMC) and lipreading ability affect the magnitude of listening effort. Twenty participants with normal hearing were tested using a paired-associates recall task in 2 conditions (quiet and noise) and 2 presentation modalities (audio only [AO] and auditory-visual [AV]). Signal-to-noise ratios were adjusted to provide matched speech recognition across audio-only and AV noise conditions. Also measured were subjective perceptions of listening effort and 2 predictive variables: (a) lipreading ability and (b) WMC. Objective and subjective results indicated that listening effort increased in the presence of noise, but on average the addition of visual cues did not significantly affect the magnitude of listening effort. Although there was substantial individual variability, on average participants who were better lipreaders or had larger WMCs demonstrated reduced listening effort in noise in AV conditions. Overall, the results support the hypothesis that integrating auditory and visual cues requires cognitive resources in some participants. The data indicate that low lipreading ability or low WMC is associated with relatively effortful integration of auditory and visual information in noise.

Ontology-based tools to expedite predictive model construction.

PubMed

Haug, Peter; Holmen, John; Wu, Xinzi; Mynam, Kumar; Ebert, Matthew; Ferraro, Jeffrey

2014-01-01

Large amounts of medical data are collected electronically during the course of caring for patients using modern medical information systems. This data presents an opportunity to develop clinically useful tools through data mining and observational research studies. However, the work necessary to make sense of this data and to integrate it into a research initiative can require substantial effort from medical experts as well as from experts in medical terminology, data extraction, and data analysis. This slows the process of medical research. To reduce the effort required for the construction of computable, diagnostic predictive models, we have developed a system that hybridizes a medical ontology with a large clinical data warehouse. Here we describe components of this system designed to automate the development of preliminary diagnostic models and to provide visual clues that can assist the researcher in planning for further analysis of the data behind these models.

Experience Transitioning Models and Data at the NOAA Space Weather Prediction Center

NASA Astrophysics Data System (ADS)

Berger, Thomas

2016-07-01

The NOAA Space Weather Prediction Center has a long history of transitioning research data and models into operations and with the validation activities required. The first stage in this process involves demonstrating that the capability has sufficient value to customers to justify the cost needed to transition it and to run it continuously and reliably in operations. Once the overall value is demonstrated, a substantial effort is then required to develop the operational software from the research codes. The next stage is to implement and test the software and product generation on the operational computers. Finally, effort must be devoted to establishing long-term measures of performance, maintaining the software, and working with forecasters, customers, and researchers to improve over time the operational capabilities. This multi-stage process of identifying, transitioning, and improving operational space weather capabilities will be discussed using recent examples. Plans for future activities will also be described.

What role do hurricanes play in sediment delivery to subsiding river deltas?

USGS Publications Warehouse

Smith, James E.; Bentley, Samuel J.; Snedden, Gregg; White, Crawford

2015-01-01

The Mississippi River Delta (MRD) has undergone tremendous land loss over the past century due to natural and anthropogenic influences, a fate shared by many river deltas globally. A globally unprecedented effort to restore and sustain the remaining subaerial portions of the delta is now underway, an endeavor that is expected to cost $50–100B over the next 50 yr. Success of this effort requires a thorough understanding of natural and anthropogenic controls on sediment supply and delta geomorphology. In the MRD, hurricanes have been paradoxically identified as both substantial agents of widespread land loss, and vertical marsh sediment accretion. We present the first multi-decadal chronostratigraphic assessment of sediment supply for a major coastal basin of the MRD that assesses both fluvial and hurricane-induced contributions to sediment accumulation in deltaic wetlands. Our findings indicate that over multidecadal timescales, hurricane-induced sediment delivery may be an important contributor for deltaic wetland vertical accretion, but the contribution from hurricanes to long-term sediment accumulation is substantially less than sediment delivery supplied by existing and planned river-sediment diversions at present-day river-sediment loads.

What Role do Hurricanes Play in Sediment Delivery to Subsiding River Deltas?

NASA Astrophysics Data System (ADS)

Smith, James E.; Bentley, Samuel J.; Snedden, Gregg A.; White, Crawford

2015-12-01

The Mississippi River Delta (MRD) has undergone tremendous land loss over the past century due to natural and anthropogenic influences, a fate shared by many river deltas globally. A globally unprecedented effort to restore and sustain the remaining subaerial portions of the delta is now underway, an endeavor that is expected to cost $50-100B over the next 50 yr. Success of this effort requires a thorough understanding of natural and anthropogenic controls on sediment supply and delta geomorphology. In the MRD, hurricanes have been paradoxically identified as both substantial agents of widespread land loss, and vertical marsh sediment accretion. We present the first multi-decadal chronostratigraphic assessment of sediment supply for a major coastal basin of the MRD that assesses both fluvial and hurricane-induced contributions to sediment accumulation in deltaic wetlands. Our findings indicate that over multidecadal timescales, hurricane-induced sediment delivery may be an important contributor for deltaic wetland vertical accretion, but the contribution from hurricanes to long-term sediment accumulation is substantially less than sediment delivery supplied by existing and planned river-sediment diversions at present-day river-sediment loads.

Assessing Provincial PM2.5 Trends in China from 2001 to 2015 Using High-Resolution Satellite Remote Sensing

NASA Astrophysics Data System (ADS)

Lin, C.; Lau, A. K. H.; LI, Y.; Li, C.

2017-12-01

Given the vast territory of China, control efforts for air pollution and the long-term PM2.5 trends may substantially differ among the provinces. In this study, we aim to assess the provincial PM2.5 trends in China during the past few Five-Year Plan (FYP) periods. The lack of long-term PM2.5 measurements, however, makes such assessment difficult. Satellite remote sensing of PM2.5 concentration is an important step toward filling this data gap. In this study, a PM2.5 data set was built over China at a resolution of 1 km from 2001 to 2015 using satellite remote sensing. Analyses show that the national average of PM2.5 concentration increased by 0.11 µg·m-3·yr-1 during the 10th FYP period (2001 to 2005) and started to decline by -0.75 µg·m-3·yr-1 and -2.20 µg·m-3·yr-1 during the 11th (2006 to 2010) and the 12th (2011 to 2015) FYP period, respectively. In addition, substantial differences in the PM2.5 trends were observed among the provinces. Although PM2.5 concentrations remained steady or worsened in most provinces during the 10th FYP period, PM2.5 concentrations substantially declined for provinces in the Beijing-Tianjin-Hebei (BTH) region, suggesting that these provinces were the most successful in their control efforts during this period. The most substantial decline in provincial PM2.5 concentration during the 12th FYP period was also observed in the BTH region. In contrast, PM2.5 concentrations remained steady for provinces in eastern and southeastern China (e.g., Shanghai) during the 12th FYP period, suggesting that these provinces have been less successful in controlling PM2.5 concentrations since 2011 and therefore require more efforts to effectively reduce the PM2.5 concentrations in future.

Occupational hazards for fishermen in the workplace in Polish coastal and beach fishing--a point of view.

PubMed

Jeżewska, Maria; Grubman-Nowak, Marta; Leszczyñska, Irena; Jaremin, Bogdan

2012-01-01

The work of marine fishermen is considered one of the most dangerous and life-threatening professions all over the world. There are some common features of the fishing occupation, such as: exposure to cold, wind, rough seas, substantial participation of physical effort, frequency of injuries during work, unpredictability and abruptness of threats, equipment failure, everyday psychological stress, and constant economic pressure. At the same time, the specificity and variety of hazards, depending significantly on geographical-climate and cultural factors, makes the dissimilarity of problems and solutions substantial in different sectors of fishing. The present article is a review of the problems of Polish costal fishermen, referring to some local particularities within this extremely difficult profession requiring special predispositions.

On the importance of controlling for effort in analysis of count survey data: Modeling population change from Christmas Bird Count data

USGS Publications Warehouse

Link, W.A.; Sauer, J.R.; Helbig, Andreas J.; Flade, Martin

1999-01-01

Count survey data are commonly used for estimating temporal and spatial patterns of population change. Since count surveys are not censuses, counts can be influenced by 'nuisance factors' related to the probability of detecting animals but unrelated to the actual population size. The effects of systematic changes in these factors can be confounded with patterns of population change. Thus, valid analysis of count survey data requires the identification of nuisance factors and flexible models for their effects. We illustrate using data from the Christmas Bird Count (CBC), a midwinter survey of bird populations in North America. CBC survey effort has substantially increased in recent years, suggesting that unadjusted counts may overstate population growth (or understate declines). We describe a flexible family of models for the effect of effort, that includes models in which increasing effort leads to diminishing returns in terms of the number of birds counted.

Cockpit data management

NASA Technical Reports Server (NTRS)

Groce, J. L.; Boucek, G. P.

1988-01-01

This study is a continuation of an FAA effort to alleviate the growing problems of assimilating and managing the flow of data and flight related information in the air transport flight deck. The nature and extent of known pilot interface problems arising from new NAS data management programs were determined by a comparative timeline analysis of crew tasking requirements. A baseline of crew tasking requirements was established for conventional and advanced flight decks operating in the current NAS environment and then compared to the requirements for operation in a future NAS environment emphasizing Mode-S data link and TCAS. Results showed that a CDU-based pilot interface for Mode-S data link substantially increased crew visual activity as compared to the baseline. It was concluded that alternative means of crew interface should be available during high visual workload phases of flight. Results for TCAS implementation showed substantial visual and motor tasking increases, and that there was little available time between crew tasks during a TCAS encounter. It was concluded that additional research should be undertaken to address issues of ATC coordination and the relative benefit of high workload TCAS features.

Establishing Theater Command and Control In a Coalition of Nations: Requirements for U.S. Doctrine

DTIC Science & Technology

1992-05-01

difficult and time consuming to establish effective coalition relations . Given the above, US doctrine for coalition theater C2 must go beyond the...make a disproportionate effort to do so. Related to the shared cultural heritage Is a common religious history. Both nations were predominantly Judeo...Inhibited. 6 The language difference too was substantial. The Korean language, Hangul, Is related to Chinese, but with Its own alphabet, one that bears no

Collaboration in Arctic Research: Best Practices to Build and Sustain Successful Cross- and Trans-disciplinary Efforts

NASA Astrophysics Data System (ADS)

Wiggins, H. V.; Rich, R. H.

2015-12-01

The rapid physical and social changes currently underway in the Arctic - and changes in the way in which we study and manage the region -- require coordinated research efforts to improve our understanding of the Arctic's physical, biological, and social systems and the implications of change at many scales. At the same time, policy-makers and Arctic communities need decision-support tools and synthesized information to respond and adapt to the "new Arctic". There are enormous challenges, however, in collaboration among the disparate groups of people needed for such efforts. A carefully planned strategic approach is required to bridge the scientific disciplinary and organizational boundaries, foster cooperation between local communities and science programs, and effectively communicate between scientists and policy-makers. Efforts must draw on bodies of knowledge from project management, strategic planning, organizational development, and group dynamics. This poster presentation will discuss best practices of building and sustaining networks of people to catalyze successful cross-disciplinary activities. Specific examples and case studies - both successes and failures -- will be presented that draw on several projects at the Arctic Research Consortium of the U.S. (ARCUS; www.arcus.org), a nonprofit membership organization composed of universities and institutions that have a substantial commitment to research in the Arctic.

Best Practices of Collaboration in Arctic Research: How to Succeed, or Fail, in Cross-Disciplinary Efforts

NASA Astrophysics Data System (ADS)

Wiggins, H. V.

2014-12-01

The rapid physical and social changes currently underway in the Arctic - and changes in the way in which we study and manage the region - require coordinated research efforts to improve our understanding of the Arctic's physical, biological, and social systems. At the same time, policy-makers and Arctic communities need decision-support tools and synthesized information to respond and adapt to the "new arctic". There are enormous challenges, however, in collaboration among the disparate groups of people needed for such efforts. A carefully planned strategic approach is required to bridge the scientific disciplinary and organizational boundaries, foster cooperation between local communities and science programs, and effectively communicate between scientists and policy-makers. Efforts must draw on bodies of knowledge from project management, strategic planning, organizational development, group dynamics, and other fields. In addition, collaborations between scientific disciplines face challenges unique to scientific culture. This poster presentation will discuss best practices of building and sustaining networks of people to catalyze successful cross-disciplinary activities. Specific examples and case studies - both successes and failures - will be presented that draw on several projects at the Arctic Research Consortium of the U.S. (ARCUS; www.arcus.org), a nonprofit membership organization composed of universities and institutions that have a substantial commitment to research in the Arctic.

Biomechanical energy harvesting: generating electricity during walking with minimal user effort.

PubMed

Donelan, J M; Li, Q; Naing, V; Hoffer, J A; Weber, D J; Kuo, A D

2008-02-08

We have developed a biomechanical energy harvester that generates electricity during human walking with little extra effort. Unlike conventional human-powered generators that use positive muscle work, our technology assists muscles in performing negative work, analogous to regenerative braking in hybrid cars, where energy normally dissipated during braking drives a generator instead. The energy harvester mounts at the knee and selectively engages power generation at the end of the swing phase, thus assisting deceleration of the joint. Test subjects walking with one device on each leg produced an average of 5 watts of electricity, which is about 10 times that of shoe-mounted devices. The cost of harvesting-the additional metabolic power required to produce 1 watt of electricity-is less than one-eighth of that for conventional human power generation. Producing substantial electricity with little extra effort makes this method well-suited for charging powered prosthetic limbs and other portable medical devices.

Streamlining Collaborative Planning in Spacecraft Mission Architectures

NASA Technical Reports Server (NTRS)

Misra, Dhariti; Bopf, Michel; Fishman, Mark; Jones, Jeremy; Kerbel, Uri; Pell, Vince

2000-01-01

During the past two decades, the planning and scheduling community has substantially increased the capability and efficiency of individual planning and scheduling systems. Relatively recently, research work to streamline collaboration between planning systems is gaining attention. Spacecraft missions stand to benefit substantially from this work as they require the coordination of multiple planning organizations and planning systems. Up to the present time this coordination has demanded a great deal of human intervention and/or extensive custom software development efforts. This problem will become acute with increased requirements for cross-mission plan coordination and multi -spacecraft mission planning. The Advanced Architectures and Automation Branch of NASA's Goddard Space Flight Center is taking innovative steps to define collaborative planning architectures, and to identify coordinated planning tools for Cross-Mission Campaigns. Prototypes are being developed to validate these architectures and assess the usefulness of the coordination tools by the planning community. This presentation will focus on one such planning coordination too], named Visual Observation Layout Tool (VOLT), which is currently being developed to streamline the coordination between astronomical missions

Development and qualification of the US Cruise Missile Propulsion System

NASA Astrophysics Data System (ADS)

Reardon, William H.; Cifone, Anthony J.

1992-09-01

This paper provides a description of the very successful Cruise Missile gas turbine propulsion program managed by the United States Department of Defense. The paper contains a summary of the procurement process, the technical and programmatic milestones, issues and challenges, and lessons learned. In the past fifteen years, testing at the Naval Air Propulsion Center has included over 800 cruise engine development and component substantiation efforts spanning the engine specification qualification requirements. This paper provides a detailed account of environmental test techniques used to qualify the F107 family of gas turbine engines which propel the U.S. Cruise Missile. In addition, a missile freestream flight test simulation for the TOMAHAWK Cruise Missile is discussed along with current and future program efforts.

Public release of the ISC-GEM Global Instrumental Earthquake Catalogue (1900-2009)

USGS Publications Warehouse

Storchak, Dmitry A.; Di Giacomo, Domenico; Bondára, István; Engdahl, E. Robert; Harris, James; Lee, William H.K.; Villaseñor, Antonio; Bormann, Peter

2013-01-01

The International Seismological Centre–Global Earthquake Model (ISC–GEM) Global Instrumental Earthquake Catalogue (1900–2009) is the result of a special effort to substantially extend and improve currently existing global catalogs to serve the requirements of specific user groups who assess and model seismic hazard and risk. The data from the ISC–GEM Catalogue would be used worldwide yet will prove absolutely essential in those regions where a high seismicity level strongly correlates with a high population density.

Supersonic Post-Combustion Inertial CO 2 Extraction System Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balepin, Vladimir

This report summarizes the effort carried out under NETL contract DE- FE0013122 from 1 October 2013 to 31 March 2017. As described in this document, technical challenges realized during the performance of this project resulted in completion of only the first two of three planned budget periods. Despite this outcome, substantial progress was made toward understanding and maturing the CO 2 capture technology under consideration and considerable future promise remains for applications requiring lower CO 2 capture and/or lower CO 2.

Elimination sequence optimization for SPAR

NASA Technical Reports Server (NTRS)

Hogan, Harry A.

1986-01-01

SPAR is a large-scale computer program for finite element structural analysis. The program allows user specification of the order in which the joints of a structure are to be eliminated since this order can have significant influence over solution performance, in terms of both storage requirements and computer time. An efficient elimination sequence can improve performance by over 50% for some problems. Obtaining such sequences, however, requires the expertise of an experienced user and can take hours of tedious effort to affect. Thus, an automatic elimination sequence optimizer would enhance productivity by reducing the analysts' problem definition time and by lowering computer costs. Two possible methods for automating the elimination sequence specifications were examined. Several algorithms based on the graph theory representations of sparse matrices were studied with mixed results. Significant improvement in the program performance was achieved, but sequencing by an experienced user still yields substantially better results. The initial results provide encouraging evidence that the potential benefits of such an automatic sequencer would be well worth the effort.

Newspaper archives + text mining = rich sources of historical geo-spatial data

NASA Astrophysics Data System (ADS)

Yzaguirre, A.; Smit, M.; Warren, R.

2016-04-01

Newspaper archives are rich sources of cultural, social, and historical information. These archives, even when digitized, are typically unstructured and organized by date rather than by subject or location, and require substantial manual effort to analyze. The effort of journalists to be accurate and precise means that there is often rich geo-spatial data embedded in the text, alongside text describing events that editors considered to be of sufficient importance to the region or the world to merit column inches. A regional newspaper can add over 100,000 articles to its database each year, and extracting information from this data for even a single country would pose a substantial Big Data challenge. In this paper, we describe a pilot study on the construction of a database of historical flood events (location(s), date, cause, magnitude) to be used in flood assessment projects, for example to calibrate models, estimate frequency, establish high water marks, or plan for future events in contexts ranging from urban planning to climate change adaptation. We then present a vision for extracting and using the rich geospatial data available in unstructured text archives, and suggest future avenues of research.

A design for a reusable Ada library

NASA Technical Reports Server (NTRS)

Litke, John D.

1986-01-01

A goal of the Ada language standardization effort is to promote reuse of software, implying the existence of substantial software libraries and the storage/retrieval mechanisms to support them. A searching/cataloging mechanism is proposed that permits full or partial distribution of the database, adapts to a variety of searching mechanisms, permits a changine taxonomy with minimal disruption, and minimizes the requirement of specialized cataloger/indexer skills. The important observation is that key words serve not only as indexing mechanism, but also as an identification mechanism, especially via concatenation and as support for a searching mechanism. By deliberately separating these multiple uses, the modifiability and ease of growth that current libraries require, is achieved.

Particle and Photon Detection: Counting and Energy Measurement

PubMed Central

Janesick, James; Tower, John

2016-01-01

Fundamental limits for photon counting and photon energy measurement are reviewed for CCD and CMOS imagers. The challenges to extend photon counting into the visible/nIR wavelengths and achieve energy measurement in the UV with specific read noise requirements are discussed. Pixel flicker and random telegraph noise sources are highlighted along with various methods used in reducing their contribution on the sensor’s read noise floor. Practical requirements for quantum efficiency, charge collection efficiency, and charge transfer efficiency that interfere with photon counting performance are discussed. Lastly we will review current efforts in reducing flicker noise head-on, in hopes to drive read noise substantially below 1 carrier rms. PMID:27187398

Initial dynamic load estimates during configuration design

NASA Technical Reports Server (NTRS)

Schiff, Daniel

1987-01-01

This analysis includes the structural response to shock and vibration and evaluates the maximum deflections and material stresses and the potential for the occurrence of elastic instability, fatigue and fracture. The required computations are often performed by means of finite element analysis (FEA) computer programs in which the structure is simulated by a finite element model which may contain thousands of elements. The formulation of a finite element model can be time consuming, and substantial additional modeling effort may be necessary if the structure requires significant changes after initial analysis. Rapid methods for obtaining rough estimates of the structural response to shock and vibration are presented for the purpose of providing guidance during the initial mechanical design configuration stage.

The Ecological Areawide Management (TEAM) of leafy spurge program of the United States Department of Agriculture-Agricultural Research Service.

PubMed

Anderson, Gerald L; Prosser, Chad W; Wendel, Lloyd E; Delfosse, Ernest S; Faust, Robert M

2003-01-01

The Ecological Areawide Management (TEAM) of Leafy Spurge program was developed to focus research and control efforts on a single weed, leafy spurge, and demonstrate the effectiveness of a coordinated, biologically based, integrated pest management program (IPM). This was accomplished through partnerships and teamwork that clearly demonstrated the advantages of the biologically based IPM approach. However, the success of regional weed control programs horizontally across several states and provinces also requires a vertical integration of several sectors of society. Awareness and education are the essential elements of vertical integration. Therefore, a substantial effort was made to produce a wide variety of information products specifically designed to educate different segments of society. During its tenure, land managers and agency decision makers have seen the potential of using the TEAM approach to accelerate the regional control of leafy spurge. The example set by the TEAM organization and participants is viewed as a model for future weed-control efforts.

Investing in Obesity Treatment: Kaiser Permanente's Approach to Chronic Disease Management.

PubMed

Tsai, Adam G; Histon, Trina; Donahoo, W Troy; Hashmi, Shahid; Murali, Sameer; Latare, Peggy; Oliver, Lajune; Slovis, Jennifer; Grall, Sarah; Fisher, David; Solomon, Loel

2016-09-01

Kaiser Permanente, an integrated health care delivery system in the USA, takes a "whole systems" approach to the chronic disease of obesity that begins with efforts to prevent it by modifying the environment in communities and schools. Aggressive case-finding and substantial investment in intensive lifestyle modification programs target individuals at high risk of diabetes and other weight-related conditions. Kaiser Permanente regions are increasingly standardizing their approach when patients with obesity require treatment intensification using medically supervised diets, prescription medication to treat obesity, or weight loss surgery.

Proceedings of the Navy Symposium on Aeroballistics (12th) Held at the David Taylor Naval Ship Research and Development Center, Bethesda, Maryland on 12-14 May 1981. Volume I.

DTIC Science & Technology

1981-05-01

hypersonic missiles will require high-lift, low-drag configu- rations with good control effectiveness . Non-circular airframe configurations that...substantial effort to devise cost effective wind tunnel systems. The result has been a number of good systems coupling hardware and computer systems...I lating a center bay, comparison is not good as shown in Figure 12. The effect of the dispenser angle of attack on the submissile aerodynamics is

The Isolation of Motivational, Motoric, and Schedule Effects on Operant Performance: A Modeling Approach

PubMed Central

Brackney, Ryan J; Cheung, Timothy H. C; Neisewander, Janet L; Sanabria, Federico

2011-01-01

Dissociating motoric and motivational effects of pharmacological manipulations on operant behavior is a substantial challenge. To address this problem, we applied a response-bout analysis to data from rats trained to lever press for sucrose on variable-interval (VI) schedules of reinforcement. Motoric, motivational, and schedule factors (effort requirement, deprivation level, and schedule requirements, respectively) were manipulated. Bout analysis found that interresponse times (IRTs) were described by a mixture of two exponential distributions, one characterizing IRTs within response bouts, another characterizing intervals between bouts. Increasing effort requirement lengthened the shortest IRT (the refractory period between responses). Adding a ratio requirement increased the length and density of response bouts. Both manipulations also decreased the bout-initiation rate. In contrast, food deprivation only increased the bout-initiation rate. Changes in the distribution of IRTs over time showed that responses during extinction were also emitted in bouts, and that the decrease in response rate was primarily due to progressively longer intervals between bouts. Taken together, these results suggest that changes in the refractory period indicate motoric effects, whereas selective alterations in bout initiation rate indicate incentive-motivational effects. These findings support the use of response-bout analyses to identify the influence of pharmacological manipulations on processes underlying operant performance. PMID:21765544

Computational analysis of high resolution unsteady airloads for rotor aeroacoustics

NASA Technical Reports Server (NTRS)

Quackenbush, Todd R.; Lam, C.-M. Gordon; Wachspress, Daniel A.; Bliss, Donald B.

1994-01-01

The study of helicopter aerodynamic loading for acoustics applications requires the application of efficient yet accurate simulations of the velocity field induced by the rotor's vortex wake. This report summarizes work to date on the development of such an analysis, which builds on the Constant Vorticity Contour (CVC) free wake model, previously implemented for the study of vibratory loading in the RotorCRAFT computer code. The present effort has focused on implementation of an airload reconstruction approach that computes high resolution airload solutions of rotor/rotor-wake interactions required for acoustics computations. Supplementary efforts on the development of improved vortex core modeling, unsteady aerodynamic effects, higher spatial resolution of rotor loading, and fast vortex wake implementations have substantially enhanced the capabilities of the resulting software, denoted RotorCRAFT/AA (AeroAcoustics). Results of validation calculations using recently acquired model rotor data show that by employing airload reconstruction it is possible to apply the CVC wake analysis with temporal and spatial resolution suitable for acoustics applications while reducing the computation time required by one to two orders of magnitude relative to that required by direct calculations. Promising correlation with this body of airload and noise data has been obtained for a variety of rotor configurations and operating conditions.

Physical and cognitive effort discounting across different reward magnitudes: Tests of discounting models

PubMed Central

Ostaszewski, Paweł

2017-01-01

The effort required to obtain a rewarding outcome is an important factor in decision-making. Describing the reward devaluation by increasing effort intensity is substantial to understanding human preferences, because every action and choice that we make is in itself effortful. To investigate how reward valuation is affected by physical and cognitive effort, we compared mathematical discounting functions derived from research on discounting. Seven discounting models were tested across three different reward magnitudes. To test the models, data were collected from a total of 114 participants recruited from the general population. For one-parameter models (hyperbolic, exponential, and parabolic), the data were explained best by the exponential model as given by a percentage of explained variance. However, after introducing an additional parameter, data obtained in the cognitive and physical effort conditions were best described by the power function model. Further analysis, using the second order Akaike and Bayesian Information Criteria, which account for model complexity, allowed us to identify the best model among all tested. We found that the power function best described the data, which corresponds to conventional analyses based on the R2 measure. This supports the conclusion that the function best describing reward devaluation by physical and cognitive effort is a concave one and is different from those that describe delay or probability discounting. In addition, consistent magnitude effects were observed that correspond to those in delay discounting research. PMID:28759631

Redesigning photosynthesis to sustainably meet global food and bioenergy demand

PubMed Central

Ort, Donald R.; Merchant, Sabeeha S.; Alric, Jean; Barkan, Alice; Blankenship, Robert E.; Bock, Ralph; Croce, Roberta; Hanson, Maureen R.; Hibberd, Julian M.; Long, Stephen P.; Moore, Thomas A.; Moroney, James; Niyogi, Krishna K.; Parry, Martin A. J.; Peralta-Yahya, Pamela P.; Prince, Roger C.; Redding, Kevin E.; Spalding, Martin H.; van Wijk, Klaas J.; Vermaas, Wim F. J.; von Caemmerer, Susanne; Weber, Andreas P. M.; Yeates, Todd O.; Yuan, Joshua S.; Zhu, Xin Guang

2015-01-01

The world’s crop productivity is stagnating whereas population growth, rising affluence, and mandates for biofuels put increasing demands on agriculture. Meanwhile, demand for increasing cropland competes with equally crucial global sustainability and environmental protection needs. Addressing this looming agricultural crisis will be one of our greatest scientific challenges in the coming decades, and success will require substantial improvements at many levels. We assert that increasing the efficiency and productivity of photosynthesis in crop plants will be essential if this grand challenge is to be met. Here, we explore an array of prospective redesigns of plant systems at various scales, all aimed at increasing crop yields through improved photosynthetic efficiency and performance. Prospects range from straightforward alterations, already supported by preliminary evidence of feasibility, to substantial redesigns that are currently only conceptual, but that may be enabled by new developments in synthetic biology. Although some proposed redesigns are certain to face obstacles that will require alternate routes, the efforts should lead to new discoveries and technical advances with important impacts on the global problem of crop productivity and bioenergy production. PMID:26124102

Semi-Automatic In Silico Gap Closure Enabled De Novo Assembly of Two Dehalobacter Genomes from Metagenomic Data

PubMed Central

Tang, Shuiquan; Gong, Yunchen; Edwards, Elizabeth A.

2012-01-01

Typically, the assembly and closure of a complete bacterial genome requires substantial additional effort spent in a wet lab for gap resolution and genome polishing. Assembly is further confounded by subspecies polymorphism when starting from metagenome sequence data. In this paper, we describe an in silico gap-resolution strategy that can substantially improve assembly. This strategy resolves assembly gaps in scaffolds using pre-assembled contigs, followed by verification with read mapping. It is capable of resolving assembly gaps caused by repetitive elements and subspecies polymorphisms. Using this strategy, we realized the de novo assembly of the first two Dehalobacter genomes from the metagenomes of two anaerobic mixed microbial cultures capable of reductive dechlorination of chlorinated ethanes and chloroform. Only four additional PCR reactions were required even though the initial assembly with Newbler v. 2.5 produced 101 contigs within 9 scaffolds belonging to two Dehalobacter strains. By applying this strategy to the re-assembly of a recently published genome of Bacteroides, we demonstrate its potential utility for other sequencing projects, both metagenomic and genomic. PMID:23284863

Effort in Multitasking: Local and Global Assessment of Effort.

PubMed

Kiesel, Andrea; Dignath, David

2017-01-01

When performing multiple tasks in succession, self-organization of task order might be superior compared to external-controlled task schedules, because self-organization allows optimizing processing modes and thus reduces switch costs, and it increases commitment to task goals. However, self-organization is an additional executive control process that is not required if task order is externally specified and as such it is considered as time-consuming and effortful. To compare self-organized and externally controlled task scheduling, we suggest assessing global subjective and objectives measures of effort in addition to local performance measures. In our new experimental approach, we combined characteristics of dual tasking settings and task switching settings and compared local and global measures of effort in a condition with free choice of task sequence and a condition with cued task sequence. In a multi-tasking environment, participants chose the task order while the task requirement of the not-yet-performed task remained the same. This task preview allowed participants to work on the previously non-chosen items in parallel and resulted in faster responses and fewer errors in task switch trials than in task repetition trials. The free-choice group profited more from this task preview than the cued group when considering local performance measures. Nevertheless, the free-choice group invested more effort than the cued group when considering global measures. Thus, self-organization in task scheduling seems to be effortful even in conditions in which it is beneficiary for task processing. In a second experiment, we reduced the possibility of task preview for the not-yet-performed tasks in order to hinder efficient self-organization. Here neither local nor global measures revealed substantial differences between the free-choice and a cued task sequence condition. Based on the results of both experiments, we suggest that global assessment of effort in addition to local performance measures might be a useful tool for multitasking research.

From instinct to intellect: the challenge of maintaining healthy weight in the modern world.

PubMed

Peters, J C; Wyatt, H R; Donahoo, W T; Hill, J O

2002-05-01

The global obesity epidemic is being driven in large part by a mismatch between our environment and our metabolism. Human physiology developed to function within an environment where high levels of physical activity were needed in daily life and food was inconsistently available. For most of mankind's history, physical activity has 'pulled' appetite so that the primary challenge to the physiological system for body weight control was to obtain sufficient energy intake to prevent negative energy balance and body energy loss. The current environment is characterized by a situation whereby minimal physical activity is required for daily life and food is abundant, inexpensive, high in energy density and widely available. Within this environment, food intake 'pushes' the system, and the challenge to the control system becomes to increase physical activity sufficiently to prevent positive energy balance. There does not appear to be a strong drive to increase physical activity in response to excess energy intake and there appears to be only a weak adaptive increase in resting energy expenditure in response to excess energy intake. In the modern world, the prevailing environment constitutes a constant background pressure that promotes weight gain. We propose that the modern environment has taken body weight control from an instinctual (unconscious) process to one that requires substantial cognitive effort. In the current environment, people who are not devoting substantial conscious effort to managing body weight are probably gaining weight. It is unlikely that we would be able to build the political will to undo our modern lifestyle, to change the environment back to one in which body weight control again becomes instinctual. In order to combat the growing epidemic we should focus our efforts on providing the knowledge, cognitive skills and incentives for controlling body weight and at the same time begin creating a supportive environment to allow better management of body weight.

Ebola: A holistic approach is required to achieve effective management and control

PubMed Central

Roca, Anna; Afolabi, Muhammed O.; Saidu, Yauba; Kampmann, Beate

2015-01-01

The current Ebola outbreak in West Africa has already caused substantial mortality and dire human and economic consequences. It continues to represent an alarming public health threat in the region and beyond and jeopardizes the provision of health care and other services in the affected countries. The scale of the epidemic has accelerated research efforts for diagnostics, treatment, and prevention galvanized through increased availability of funding. Our knowledge relating to the virus, disease pathogenesis, risk factors, dynamics of transmission, and epidemic control is increasing, and sociocultural factors have emerged as critical determinants for the success and failure of control efforts. However, there is a long way to go. In this review we summarize the current knowledge, examine the sociocultural context in West Africa, and outline priority areas for future research. PMID:25843598

Climate impact of beef: an analysis considering multiple time scales and production methods without use of global warming potentials

NASA Astrophysics Data System (ADS)

Pierrehumbert, R. T.; Eshel, G.

2015-08-01

An analysis of the climate impact of various forms of beef production is carried out, with a particular eye to the comparison between systems relying primarily on grasses grown in pasture (‘grass-fed’ or ‘pastured’ beef) and systems involving substantial use of manufactured feed requiring significant external inputs in the form of synthetic fertilizer and mechanized agriculture (‘feedlot’ beef). The climate impact is evaluated without employing metrics such as {{CO}}2{{e}} or global warming potentials. The analysis evaluates the impact at all time scales out to 1000 years. It is concluded that certain forms of pastured beef production have substantially lower climate impact than feedlot systems. However, pastured systems that require significant synthetic fertilization, inputs from supplemental feed, or deforestation to create pasture, have substantially greater climate impact at all time scales than the feedlot and dairy-associated systems analyzed. Even the best pastured system analyzed has enough climate impact to justify efforts to limit future growth of beef production, which in any event would be necessary if climate and other ecological concerns were met by a transition to primarily pasture-based systems. Alternate mitigation options are discussed, but barring unforseen technological breakthroughs worldwide consumption at current North American per capita rates appears incompatible with a 2 °C warming target.

Thick Galactic Cosmic Radiation Shielding Using Atmospheric Data

NASA Technical Reports Server (NTRS)

Youngquist, Robert C.; Nurge, Mark A.; Starr, Stanley O.; Koontz, Steven L.

2013-01-01

NASA is concerned with protecting astronauts from the effects of galactic cosmic radiation and has expended substantial effort in the development of computer models to predict the shielding obtained from various materials. However, these models were only developed for shields up to about 120 g!cm2 in thickness and have predicted that shields of this thickness are insufficient to provide adequate protection for extended deep space flights. Consequently, effort is underway to extend the range of these models to thicker shields and experimental data is required to help confirm the resulting code. In this paper empirically obtained effective dose measurements from aircraft flights in the atmosphere are used to obtain the radiation shielding function of the earth's atmosphere, a very thick shield. Obtaining this result required solving an inverse problem and the method for solving it is presented. The results are shown to be in agreement with current code in the ranges where they overlap. These results are then checked and used to predict the radiation dosage under thick shields such as planetary regolith and the atmosphere of Venus.

Practical Use of Computationally Frugal Model Analysis Methods

DOE PAGES

Hill, Mary C.; Kavetski, Dmitri; Clark, Martyn; ...

2015-03-21

Computationally frugal methods of model analysis can provide substantial benefits when developing models of groundwater and other environmental systems. Model analysis includes ways to evaluate model adequacy and to perform sensitivity and uncertainty analysis. Frugal methods typically require 10s of parallelizable model runs; their convenience allows for other uses of the computational effort. We suggest that model analysis be posed as a set of questions used to organize methods that range from frugal to expensive (requiring 10,000 model runs or more). This encourages focus on method utility, even when methods have starkly different theoretical backgrounds. We note that many frugalmore » methods are more useful when unrealistic process-model nonlinearities are reduced. Inexpensive diagnostics are identified for determining when frugal methods are advantageous. Examples from the literature are used to demonstrate local methods and the diagnostics. We suggest that the greater use of computationally frugal model analysis methods would allow questions such as those posed in this work to be addressed more routinely, allowing the environmental sciences community to obtain greater scientific insight from the many ongoing and future modeling efforts« less

Fifty years of herbicide research: comparing the discovery of trifluralin and halauxifen-methyl.

PubMed

Epp, Jeffrey B; Schmitzer, Paul R; Crouse, Gary D

2018-01-01

Fifty years separate the commercialization of the herbicides trifluralin and halauxifen-methyl. Despite the vast degree of technological change that occurred over that time frame, some aspects of their discovery stories are remarkably similar. For example, both herbicides were prepared very early in the iterative discovery process and both were developed from known lead compound structures by hypothesis-driven research efforts without the use of in vitro assays or computer-aided molecular design. However, there are aspects of the halauxifen-methyl and trifluralin discovery stories that are substantially different. For example, the chemical technology required for the cost-effective production of halauxifen-methyl simply did not exist just two decades prior to its commercial launch. By contrast, the chemical technology required for the cost-effective production of trifluralin was reported in the chemical literature more than two decades prior to its commercial launch. In addition, changes in regulatory environment since the early 1960s ensured that their respective discovery to commercial launch stories would also differ in substantial ways. Ultimately, the time and cost required to develop and register halauxifen-methyl demanded a global initial business case while the lower registration hurdles that trifluralin cleared enabled a narrow initial business case mainly focused on the USA. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Living systematic reviews: 2. Combining human and machine effort.

PubMed

Thomas, James; Noel-Storr, Anna; Marshall, Iain; Wallace, Byron; McDonald, Steven; Mavergames, Chris; Glasziou, Paul; Shemilt, Ian; Synnot, Anneliese; Turner, Tari; Elliott, Julian

2017-11-01

New approaches to evidence synthesis, which use human effort and machine automation in mutually reinforcing ways, can enhance the feasibility and sustainability of living systematic reviews. Human effort is a scarce and valuable resource, required when automation is impossible or undesirable, and includes contributions from online communities ("crowds") as well as more conventional contributions from review authors and information specialists. Automation can assist with some systematic review tasks, including searching, eligibility assessment, identification and retrieval of full-text reports, extraction of data, and risk of bias assessment. Workflows can be developed in which human effort and machine automation can each enable the other to operate in more effective and efficient ways, offering substantial enhancement to the productivity of systematic reviews. This paper describes and discusses the potential-and limitations-of new ways of undertaking specific tasks in living systematic reviews, identifying areas where these human/machine "technologies" are already in use, and where further research and development is needed. While the context is living systematic reviews, many of these enabling technologies apply equally to standard approaches to systematic reviewing. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Creation of a small high-throughput screening facility.

PubMed

Flak, Tod

2009-01-01

The creation of a high-throughput screening facility within an organization is a difficult task, requiring a substantial investment of time, money, and organizational effort. Major issues to consider include the selection of equipment, the establishment of data analysis methodologies, and the formation of a group having the necessary competencies. If done properly, it is possible to build a screening system in incremental steps, adding new pieces of equipment and data analysis modules as the need grows. Based upon our experience with the creation of a small screening service, we present some guidelines to consider in planning a screening facility.

Transferring technology to the public sector.

NASA Technical Reports Server (NTRS)

Alper, M. E.

1972-01-01

Approximately four years ago the Jet Propulsion Laboratory, under NASA sponsorship, began to devote some of its resources to examining ways to transfer space technology to the civil sector. As experience accumulated under this program, certain principles basic to success in technology transfer became apparent. An adequate definition of each problem must be developed before any substantial effort is expended on a solution. In most instances, a source of funds other than the potential user is required to support the problem definition phase of the work. Sensitivity to the user's concerns and effective interpersonal communications between the user and technical personnel are essential to success.

Theories of willpower affect sustained learning.

PubMed

Miller, Eric M; Walton, Gregory M; Dweck, Carol S; Job, Veronika; Trzesniewski, Kali H; McClure, Samuel M

2012-01-01

Building cognitive abilities often requires sustained engagement with effortful tasks. We demonstrate that beliefs about willpower-whether willpower is viewed as a limited or non-limited resource-impact sustained learning on a strenuous mental task. As predicted, beliefs about willpower did not affect accuracy or improvement during the initial phases of learning; however, participants who were led to view willpower as non-limited showed greater sustained learning over the full duration of the task. These findings highlight the interactive nature of motivational and cognitive processes: motivational factors can substantially affect people's ability to recruit their cognitive resources to sustain learning over time.

Theories of Willpower Affect Sustained Learning

PubMed Central

Miller, Eric M.; Walton, Gregory M.; Dweck, Carol S.; Job, Veronika; Trzesniewski, Kali H.; McClure, Samuel M.

2012-01-01

Building cognitive abilities often requires sustained engagement with effortful tasks. We demonstrate that beliefs about willpower–whether willpower is viewed as a limited or non-limited resource–impact sustained learning on a strenuous mental task. As predicted, beliefs about willpower did not affect accuracy or improvement during the initial phases of learning; however, participants who were led to view willpower as non-limited showed greater sustained learning over the full duration of the task. These findings highlight the interactive nature of motivational and cognitive processes: motivational factors can substantially affect people’s ability to recruit their cognitive resources to sustain learning over time. PMID:22745675

Recent developments in radiation field control technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wood, C.J.

1995-03-01

The U.S. nuclear power industry has been remarkably successful in reducing worker radiation exposures over the past ten years. There has been over a fourfold reduction in the person-rem incurred for each MW.year of electric power generated: from 1.8 in 1980, to only 0.39 person-rems in 1991 and 1992. Preliminary data for 1993 are even lower: approximately 0.37 person-rem.MW.year. Despite this substantial improvement, challenges for the industry remain. Individual exposure limits have been tightened in ICRP 60 and there will be increased requirements for special maintenance work as plants age, suggesting that vigorous efforts with be increased requirements for specialmore » maintenance work as plants age, suggesting that vigorous efforts will be required to meet the industry goals for 1995. Reducing out-of-core radiation fields offer the best chance of continuing the downward trend in exposures. To assist utilities select the most economic technology for their specific plants, EPRI has published a manual capturing worldwide operating experience with radiation-field control techniques (TR-100265). No one method will suffice, but implementing suitable combinations from this collection will enable utilities to achieve their exposure goals. Radiation reduction is generally cost-effective: outages are shorter, manpower requirements are reduced and work quality is improved. Despite the up front costs, the benefits over the following 1-3 years typically outweigh the expenses.« less

Motorcycle pollution control in Taiwan, Republic of China

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, H.W.; Hsiao, H.C.; Walsh, M.P.

1998-12-31

The Taiwan EPA has developed a comprehensive approach to motor vehicle pollution control. Building on its early adoption of US `83 standards for light duty vehicles (starting July 1, 1990) it recently moved to US `87 requirements, which include the 0.2 gram per mile particulate standard, as of July 1, 1995. Heavy duty diesel particulate standards almost as stringent as US `90, 6.0 grams per brake horsepower hour NO{sub x} and 0.7 particulate, using the US transient test procedure, went into effect on July 1, 1993. It is intended that US`94 standards, 5.0 NO{sub x} and 0.25 particulate, will bemore » adopted soon. Clearly the most distinctive feature of the Taiwan program, however, is its motorcycle control effort, reflecting the fact that motorcycles dominate the vehicle fleet and are a substantial source of emissions. This paper will summarize Taiwan`s extensive efforts to address this problem.« less

Ebola: a holistic approach is required to achieve effective management and control.

PubMed

Roca, Anna; Afolabi, Muhammed O; Saidu, Yauba; Kampmann, Beate

2015-04-01

The current Ebola outbreak in West Africa has already caused substantial mortality and dire human and economic consequences. It continues to represent an alarming public health threat in the region and beyond and jeopardizes the provision of health care and other services in the affected countries. The scale of the epidemic has accelerated research efforts for diagnostics, treatment, and prevention galvanized through increased availability of funding. Our knowledge relating to the virus, disease pathogenesis, risk factors, dynamics of transmission, and epidemic control is increasing, and sociocultural factors have emerged as critical determinants for the success and failure of control efforts. However, there is a long way to go. In this review we summarize the current knowledge, examine the sociocultural context in West Africa, and outline priority areas for future research. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

NASA's Commercial Space Centers: Bringing Together Government and Industry for "Out of this World" Benefits

NASA Technical Reports Server (NTRS)

Robinson, R. Keith; Henderson, Robin N. (Technical Monitor)

2002-01-01

The National Aeronautics and Space Administration (NASA) is making significant effort to accommodate commercial research in the utilization plans of the International Space Station (ISS)[1]. NASA is providing 30% of the research accommodations in the ISS laboratory modules to support commercial endeavors. However, the availability of resources alone does not necessarily translate into significant private sector participation in NASA's ISS utilization plans. Due to the efforts of NASA's Commercial Space Centers (CSC's), NASA has developed a very robust plan for involving the private sector in ISS utilization activities. Obtaining participation from the private sector requires a demonstrated capability for obtaining commercially significant research results. Since 1985, NASA CSC's have conducted over 200 commercial research activities aboard parabolic aircraft, sounding rockets, the Space Shuttle, and the ISS. The success of these activities has developed substantial investment from private sector companies in commercial space research.

Extracellular space preservation aids the connectomic analysis of neural circuits.

PubMed

Pallotto, Marta; Watkins, Paul V; Fubara, Boma; Singer, Joshua H; Briggman, Kevin L

2015-12-09

Dense connectomic mapping of neuronal circuits is limited by the time and effort required to analyze 3D electron microscopy (EM) datasets. Algorithms designed to automate image segmentation suffer from substantial error rates and require significant manual error correction. Any improvement in segmentation error rates would therefore directly reduce the time required to analyze 3D EM data. We explored preserving extracellular space (ECS) during chemical tissue fixation to improve the ability to segment neurites and to identify synaptic contacts. ECS preserved tissue is easier to segment using machine learning algorithms, leading to significantly reduced error rates. In addition, we observed that electrical synapses are readily identified in ECS preserved tissue. Finally, we determined that antibodies penetrate deep into ECS preserved tissue with only minimal permeabilization, thereby enabling correlated light microscopy (LM) and EM studies. We conclude that preservation of ECS benefits multiple aspects of the connectomic analysis of neural circuits.

Major design issues of molten carbonate fuel cell power generation unit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, T.P.

1996-04-01

In addition to the stack, a fuel cell power generation unit requires fuel desulfurization and reforming, fuel and oxidant preheating, process heat removal, waste heat recovery, steam generation, oxidant supply, power conditioning, water supply and treatment, purge gas supply, instrument air supply, and system control. These support facilities add considerable cost and system complexity. Bechtel, as a system integrator of M-C Power`s molten carbonate fuel cell development team, has spent substantial effort to simplify and minimize these supporting facilities to meet cost and reliability goals for commercialization. Similiar to other fuels cells, MCFC faces design challenge of how to complymore » with codes and standards, achieve high efficiency and part load performance, and meanwhile minimize utility requirements, weight, plot area, and cost. However, MCFC has several unique design issues due to its high operating temperature, use of molten electrolyte, and the requirement of CO2 recycle.« less

Method of Optimizing the Construction of Machining, Assembly and Control Devices

NASA Astrophysics Data System (ADS)

Iordache, D. M.; Costea, A.; Niţu, E. L.; Rizea, A. D.; Babă, A.

2017-10-01

Industry dynamics, driven by economic and social requirements, must generate more interest in technological optimization, capable of ensuring a steady development of advanced technical means to equip machining processes. For these reasons, the development of tools, devices, work equipment and control, as well as the modernization of machine tools, is the certain solution to modernize production systems that require considerable time and effort. This type of approach is also related to our theoretical, experimental and industrial applications of recent years, presented in this paper, which have as main objectives the elaboration and use of mathematical models, new calculation methods, optimization algorithms, new processing and control methods, as well as some structures for the construction and configuration of technological equipment with a high level of performance and substantially reduced costs..

The journey of primary care practices to meaningful use: a Colorado Beacon Consortium study.

PubMed

Fernald, Douglas H; Wearner, Robyn; Dickinson, W Perry

2013-01-01

The Health Information Technology for Economic and Clinical Health Act of 2009 provides for incentive payments through Medicare and Medicaid for clinicians who implement electronic health records (EHRs) and use this technology meaningfully to improve patient care. There are few comprehensive descriptions of how primary care practices achieve the meaningful use of clinical data, including the formal stage 1 meaningful use requirements. Evaluation of the Colorado Beacon Consortium project included iterative qualitative analysis of practice narratives, provider and staff interviews, and separate focus groups with quality improvement (QI) advisors and staff from the regional health information exchange (HIE). Most practices described significant realignment of practice priorities and aims, which often required substantial education and training of physicians and staff. Re-engineering office processes, data collection protocols, EHRs, staff roles, and practice culture comprised the primary effort and commitment to attest to stage 1 meaningful use and subsequent meaningful use of clinical data. While realizing important benefits, practices bore a significant burden in learning the true capabilities of their EHRs with little effective support from vendors. Attestation was an important initial milestone in the process, but practices faced substantial ongoing work to use their data meaningfully for patient care and QI. Key resources were instrumental to these practices: local technical EHR expertise; collaborative learning mechanisms; and regular contact and support from QI advisors. Meeting the stage 1 requirements for incentives under Medicare and Medicaid meaningful use criteria is the first waypoint in a longer journey by primary care practices to the meaningful use of electronic data to continuously improve the care and health of their patients. The intensive re-engineering effort for stage 1 yielded practice changes consistent with larger practice aims and goals. While many of these practices are now poised to use data meaningfully, faster progress will likely come with continued local QI and technical support and planned community-wide learning.

Effects of cryptic mortality and the hidden costs of using length limits in fishery management

USGS Publications Warehouse

Coggins, L.G.; Catalano, M.J.; Allen, M.S.; Pine, William E.; Walters, C.J.

2007-01-01

Fishery collapses cause substantial economic and ecological harm, but common management actions often fail to prevent overfishing. Minimum length limits are perhaps the most common fishing regulation used in both commercial and recreational fisheries, but their conservation benefits can be influenced by discard mortality of fish caught and released below the legal length. We constructed a computer model to evaluate how discard mortality could influence the conservation utility of minimum length regulations. We evaluated policy performance across two disparate fish life-history types: short-lived high-productivity (SLHP) and long-lived low-productivity (LLLP) species. For the life-history types, fishing mortality rates and minimum length limits that we examined, length limits alone generally failed to achieve sustainability when discard mortality rate exceeded about 0.2 for SLHP species and 0.05 for LLLP species. At these levels of discard mortality, reductions in overall fishing mortality (e.g. lower fishing effort) were required to prevent recruitment overfishing if fishing mortality was high. Similarly, relatively low discard mortality rates (>0.05) rendered maximum yield unobtainable and caused a substantial shift in the shape of the yield response surfaces. An analysis of fishery efficiency showed that length limits caused the simulated fisheries to be much less efficient, potentially exposing the target species and ecosystem to increased negative effects of the fishing process. Our findings suggest that for overexploited fisheries with moderate-to-high discard mortality rates, reductions in fishing mortality will be required to meet management goals. Resource managers should carefully consider impacts of cryptic mortality sources (e.g. discard mortality) on fishery sustainability, especially in recreational fisheries where release rates are high and effort is increasing in many areas of the world. ?? 2007 Blackwell Publishing Ltd.

IDENTIFICATION OF CFC AND HCFC SUBSTITUTES FOR BLOWING POLYURETHANE FOAM INSULATION PRODUCTS

EPA Science Inventory

The report gives results of a cooperative effort to identiry chlorofluorocarbons and hydrochlorofluorocarbon substitutes for blowing polyurethane foam insulation products. The substantial ongoing effort is identifying third-generation blowing agets for polyurethane foams to repla...

Using a formal requirements management tool for system engineering: first results at ESO

NASA Astrophysics Data System (ADS)

Zamparelli, Michele

2006-06-01

The attention to proper requirement analysis and maintenance is growing in modern astronomical undertakings. The increasing degree of complexity that current and future generations of projects have reached requires substantial system engineering efforts and the usage of all available technology to keep project development under control. One such technology is a tool which helps managing relationships between deliverables at various development stages, and across functional subsystems and disciplines as different as software, mechanics, optics and electronics. The immediate benefits are traceability and the possibility to do impact analysis. An industrially proven tool for requirements management is presented together with the first results across some projects at ESO and a cost/benefit analysis of its usage. Experience gathered so far shows that the extensibility and configurability of the tool from one hand, and integration with common documentation formats and standards on the other, make it appear as a promising solution for even small scale system development.

Test Facilities and Experience on Space Nuclear System Developments at the Kurchatov Institute

NASA Astrophysics Data System (ADS)

Ponomarev-Stepnoi, Nikolai N.; Garin, Vladimir P.; Glushkov, Evgeny S.; Kompaniets, George V.; Kukharkin, Nikolai E.; Madeev, Vicktor G.; Papin, Vladimir K.; Polyakov, Dmitry N.; Stepennov, Boris S.; Tchuniyaev, Yevgeny I.; Tikhonov, Lev Ya.; Uksusov, Yevgeny I.

2004-02-01

The complexity of space fission systems and rigidity of requirement on minimization of weight and dimension characteristics along with the wish to decrease expenditures on their development demand implementation of experimental works which results shall be used in designing, safety substantiation, and licensing procedures. Experimental facilities are intended to solve the following tasks: obtainment of benchmark data for computer code validations, substantiation of design solutions when computational efforts are too expensive, quality control in a production process, and ``iron'' substantiation of criticality safety design solutions for licensing and public relations. The NARCISS and ISKRA critical facilities and unique ORM facility on shielding investigations at the operating OR nuclear research reactor were created in the Kurchatov Institute to solve the mentioned tasks. The range of activities performed at these facilities within the implementation of the previous Russian nuclear power system programs is briefly described in the paper. This experience shall be analyzed in terms of methodological approach to development of future space nuclear systems (this analysis is beyond this paper). Because of the availability of these facilities for experiments, the brief description of their critical assemblies and characteristics is given in this paper.

Academic plastic surgery: faculty recruitment and retention.

PubMed

Chen, Jenny T; Girotto, John A; Kitzmiller, W John; Lawrence, W Thomas; Verheyden, Charles N; Vedder, Nicholas B; Coleman, John J; Bentz, Michael L

2014-03-01

A critical element of a thriving academic plastic surgery program is the quality of faculty. A decline in recruitment and retention of faculty has been attributed to the many challenges of academic medicine. Given the substantial resources required to develop faculty, academic plastic surgery has a vested interest in improving the process of faculty recruitment and retention. The American Council of Academic Plastic Surgeons Issues Committee and the American Society of Plastic Surgeons/Plastic Surgery Foundation Academic Affairs Council surveyed the 83 existing programs in academic plastic surgery in February of 2012. The survey addressed the faculty-related issues in academic plastic surgery programs over the past decade. Recruitment and retention strategies were evaluated. This study was designed to elucidate trends, and define best strategies, on a national level. Academic plastic surgery programs have added substantially more full-time faculty over the past decade. Recruitment efforts are multifaceted and can include guaranteed salary support, moving expenses, nurse practitioner/physician's assistant hires, protected time for research, seed funds to start research programs, and more. Retention efforts can include increased compensation, designation of a leadership appointment, protected academic time, and call dilution. Significant change and growth of academic plastic surgery has occurred in the past decade. Effective faculty recruitment and retention are critical to a successful academic center. Funding sources in addition to physician professional fees (institutional program support, grants, contracts, endowment, and so on) are crucial to sustain the academic missions.

Higher Order Time Integration Schemes for the Unsteady Navier-Stokes Equations on Unstructured Meshes

NASA Technical Reports Server (NTRS)

Jothiprasad, Giridhar; Mavriplis, Dimitri J.; Caughey, David A.

2002-01-01

The rapid increase in available computational power over the last decade has enabled higher resolution flow simulations and more widespread use of unstructured grid methods for complex geometries. While much of this effort has been focused on steady-state calculations in the aerodynamics community, the need to accurately predict off-design conditions, which may involve substantial amounts of flow separation, points to the need to efficiently simulate unsteady flow fields. Accurate unsteady flow simulations can easily require several orders of magnitude more computational effort than a corresponding steady-state simulation. For this reason, techniques for improving the efficiency of unsteady flow simulations are required in order to make such calculations feasible in the foreseeable future. The purpose of this work is to investigate possible reductions in computer time due to the choice of an efficient time-integration scheme from a series of schemes differing in the order of time-accuracy, and by the use of more efficient techniques to solve the nonlinear equations which arise while using implicit time-integration schemes. This investigation is carried out in the context of a two-dimensional unstructured mesh laminar Navier-Stokes solver.

Rapid and lasting gains from solving illegal fishing.

PubMed

Cabral, Reniel B; Mayorga, Juan; Clemence, Michaela; Lynham, John; Koeshendrajana, Sonny; Muawanah, Umi; Nugroho, Duto; Anna, Zuzy; Mira; Ghofar, Abdul; Zulbainarni, Nimmi; Gaines, Steven D; Costello, Christopher

2018-04-01

Perhaps the greatest challenge facing global fisheries is that recovery often requires substantial short-term reductions in fishing effort, catches and profits. These costs can be onerous and are borne in the present; thus, many countries are unwilling to undertake such socially and politically unpopular actions. We argue that many nations can recover their fisheries while avoiding these short-term costs by sharply addressing illegal, unreported and unregulated (IUU) fishing. This can spur fishery recovery, often at little or no cost to local economies or food provision. Indonesia recently implemented aggressive policies to curtail the high levels of IUU fishing it experiences from foreign-flagged vessels. We show that Indonesia's policies have reduced total fishing effort by at least 25%, illustrating with empirical evidence the possibility of achieving fishery reform without short-term losses to the local fishery economy. Compared with using typical management reforms that would require a 15% reduction in catch and 16% reduction in profit, the approach of curtailing IUU has the potential to generate a 14% increase in catch and a 12% increase in profit. Applying this model globally, we find that addressing IUU fishing could facilitate similar rapid, long-lasting fisheries gains in many regions of the world.

76 FR 69330 - Proposed Collection; Comment Request for Regulation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-08

... collection requirements related to substantiation and reporting requirements for cash and noncash charitable...: Substantiation and Reporting Requirements for Cash and Noncash Charitable Contribution Deductions. OMB Number... provide guidance concerning substantiation and reporting requirements for cash and noncash charitable...

48 CFR 15.603 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research and development or other efforts supporting the Government mission, and often represent a substantial investment of time and effort by the offeror. (b) Advertising material, commercial item offers, or... Government support could be worthwhile and the proposed work could benefit the agency's research and...

Neutron skyshine calculations for the PDX tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wheeler, F.J.; Nigg, D.W.

1979-01-01

The Poloidal Divertor Experiment (PDX) at Princeton will be the first operating tokamak to require a substantial radiation shield. The PDX shielding includes a water-filled roof shield over the machine to reduce air scattering skyshine dose in the PDX control room and at the site boundary. During the design of this roof shield a unique method was developed to compute the neutron source emerging from the top of the roof shield for use in Monte Carlo skyshine calculations. The method is based on simple, one-dimensional calculations rather than multidimensional calculations, resulting in considerable savings in computer time and input preparationmore » effort. This method is described.« less

Automatic Generation of Test Oracles - From Pilot Studies to Application

NASA Technical Reports Server (NTRS)

Feather, Martin S.; Smith, Ben

1998-01-01

There is a trend towards the increased use of automation in V&V. Automation can yield savings in time and effort. For critical systems, where thorough V&V is required, these savings can be substantial. We describe a progression from pilot studies to development and use of V&V automation. We used pilot studies to ascertain opportunities for, and suitability of, automating various analyses whose results would contribute to V&V. These studies culminated in the development of an automatic generator of automated test oracles. This was then applied and extended in the course of testing an Al planning system that is a key component of an autonomous spacecraft.

Innovative Educational Initiatives to Train Psychodynamic Psychiatrists in Underserved Areas of the World.

PubMed

Alfonso, César A; Michael, Marco Christian; Elvira, Sylvia Detri; Zakaria, Hazli; Kalayasiri, Rasmon; Adlan, Aida Syarinaz A; Moinalghorabaei, Mahdieh; Lukman, Petrin Redayani; San'ati, Mohammad; Duchonova, Katerina; Sullivan, Timothy B

2018-06-01

Psychodynamic psychiatry remains a challenging subject to teach in underserved areas, where enthusiasm to learn is substantial. Besides logistical and psychiatric workforce shortcomings, sensible cultural adaptations to make psychodynamic psychiatry relevant outside of high-income countries require creative effort. Innovative pedagogical methods that include carefully crafted mentoring and incorporate videoconferencing in combination with site visits can be implemented through international collaborations. Emphasis on mentoring is essential to adequately train future psychodynamic psychotherapy supervisors. Examples of World Psychiatric Association initiatives in countries such as Indonesia, Iran, Malaysia, and Thailand are presented as possible models to emulate elsewhere. Copyright © 2018 Elsevier Inc. All rights reserved.

Mind the gap: race/ethnic and socioeconomic disparities in obesity.

PubMed

Krueger, Patrick M; Reither, Eric N

2015-11-01

Race/ethnic and socioeconomic status (SES) disparities in obesity are substantial and may widen in the future. We review nine potential mechanisms that recent research has used to explain obesity disparities. Those nine mechanisms fall into three broad groups-health behaviors, biological factors, and the social environment-which incorporate both proximate and upstream determinants of obesity disparities. Efforts to reduce the prevalence of obesity in the US population and to close race/ethnic and SES disparities in obesity will likely require the use of multifaceted interventions that target multiple mechanisms simultaneously. Unfortunately, relatively few of the mechanisms reviewed herein have been tested in an intervention framework.

STATISTICAL ANALYSIS OF SNAP 10A THERMOELECTRIC CONVERTER ELEMENT PROCESS DEVELOPMENT VARIABLES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fitch, S.H.; Morris, J.W.

1962-12-15

Statistical analysis, primarily analysis of variance, was applied to evaluate several factors involved in the development of suitable fabrication and processing techniques for the production of lead telluride thermoelectric elements for the SNAP 10A energy conversion system. The analysis methods are described as to their application for determining the effects of various processing steps, estabIishing the value of individual operations, and evaluating the significance of test results. The elimination of unnecessary or detrimental processing steps was accomplished and the number of required tests was substantially reduced by application of these statistical methods to the SNAP 10A production development effort. (auth)

Application of Adaptive Beamforming to Signal Observations at the Mt. Meron Array, Israel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, D. B.

2010-06-07

The Mt. Meron array consists of 16 stations spanning an aperture of 3-4 kilometers in northern Israel. The array is situated in a region of substantial topographic relief, and is surrounded by settlements at close range (Figure 1). Consequently the level of noise at the array is high, which requires efforts at mitigation if distant regional events of moderate magnitude are to be observed. This note describes an initial application of two classic adaptive beamforming algorithms to data from the array to observe P waves from 5 events east of the array ranging in distance from 1100- 2150 kilometers.

Adaptive subdomain modeling: A multi-analysis technique for ocean circulation models

NASA Astrophysics Data System (ADS)

Altuntas, Alper; Baugh, John

2017-07-01

Many coastal and ocean processes of interest operate over large temporal and geographical scales and require a substantial amount of computational resources, particularly when engineering design and failure scenarios are also considered. This study presents an adaptive multi-analysis technique that improves the efficiency of these computations when multiple alternatives are being simulated. The technique, called adaptive subdomain modeling, concurrently analyzes any number of child domains, with each instance corresponding to a unique design or failure scenario, in addition to a full-scale parent domain providing the boundary conditions for its children. To contain the altered hydrodynamics originating from the modifications, the spatial extent of each child domain is adaptively adjusted during runtime depending on the response of the model. The technique is incorporated in ADCIRC++, a re-implementation of the popular ADCIRC ocean circulation model with an updated software architecture designed to facilitate this adaptive behavior and to utilize concurrent executions of multiple domains. The results of our case studies confirm that the method substantially reduces computational effort while maintaining accuracy.

Development of nonproliferation and assessment scenarios.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finley, Melissa; Barnett, Natalie Beth

2005-10-01

The overall objective of the Nonproliferation and Assessments Scenario Development project is to create and analyze potential and plausible scenarios that would lead to an adversary's ability to acquire and use a biological weapon. The initial three months of funding was intended to be used to develop a scenario to demonstrate the efficacy of this analysis methodology; however, it was determined that a substantial amount of preliminary data collection would be needed before a proof of concept scenario could be developed. We have dedicated substantial effort to determine the acquisition pathways for Foot and Mouth Disease Virus, and similar processesmore » will be applied to all pathogens of interest. We have developed a biosecurity assessments database to capture information on adversary skill locales, available skill sets in specific regions, pathogen sources and regulations involved in pathogen acquisition from legitimate facilities. FY06 funding, once released, will be dedicated to data collection on acquisition, production and dissemination requirements on a pathogen basis. Once pathogen data has been collected, scenarios will be developed and scored.« less

Shared vision and autonomous motivation vs. financial incentives driving success in corporate acquisitions

PubMed Central

Clayton, Byron C.

2015-01-01

Successful corporate acquisitions require its managers to achieve substantial performance improvements in order to sufficiently cover acquisition premiums, the expected return of debt and equity investors, and the additional resources needed to capture synergies and accelerate growth. Acquirers understand that achieving the performance improvements necessary to cover these costs and create value for investors will most likely require a significant effort from mergers and acquisitions (M&A) management teams. This understanding drives the common and longstanding practice of offering hefty performance incentive packages to key managers, assuming that financial incentives will induce in-role and extra-role behaviors that drive organizational change and growth. The present study debunks the assumptions of this common M&A practice, providing quantitative evidence that shared vision and autonomous motivation are far more effective drivers of managerial performance than financial incentives. PMID:25610406

Shared vision and autonomous motivation vs. financial incentives driving success in corporate acquisitions.

PubMed

Clayton, Byron C

2014-01-01

Successful corporate acquisitions require its managers to achieve substantial performance improvements in order to sufficiently cover acquisition premiums, the expected return of debt and equity investors, and the additional resources needed to capture synergies and accelerate growth. Acquirers understand that achieving the performance improvements necessary to cover these costs and create value for investors will most likely require a significant effort from mergers and acquisitions (M&A) management teams. This understanding drives the common and longstanding practice of offering hefty performance incentive packages to key managers, assuming that financial incentives will induce in-role and extra-role behaviors that drive organizational change and growth. The present study debunks the assumptions of this common M&A practice, providing quantitative evidence that shared vision and autonomous motivation are far more effective drivers of managerial performance than financial incentives.

HGML: a hypertext guideline markup language.

PubMed Central

Hagerty, C. G.; Pickens, D.; Kulikowski, C.; Sonnenberg, F.

2000-01-01

Existing text-based clinical practice guidelines can be difficult to put into practice. While a growing number of such documents have gained acceptance in the medical community and contain a wealth of valuable information, the time required to digest them is substantial. Yet the expressive power, subtlety and flexibility of natural language pose challenges when designing computer tools that will help in their application. At the same time, formal computer languages typically lack such expressiveness and the effort required to translate existing documents into these languages may be costly. We propose a method based on the mark-up concept for converting text-based clinical guidelines into a machine-operable form. This allows existing guidelines to be manipulated by machine, and viewed in different formats at various levels of detail according to the needs of the practitioner, while preserving their originally published form. PMID:11079898

What Is School Enterprise?

ERIC Educational Resources Information Center

Brown, Daniel J.

1995-01-01

A survey of administrators and teachers in 20 British Columbia school districts that had experienced substantial reductions in public funding examined efforts to raise additional funds from private sources. Activities included casinos (bingo), requests for donations, sales of goods to the community, grant writing, and entrepreneurial efforts.…

48 CFR 35.009 - Subcontracting research and development effort.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.009 Subcontracting research and development effort. Since the selection of R&D contractors is substantially based on... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontracting research...

Commercial Electric Vehicle (EV) Development and Manufacturing Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leeve, Dion

Navistar with the Department of Energy’s assistance undertook this effort to achieve the project objectives as listed in the next section. A wholly owned subsidiary of Navistar, Workhorse Sales Corporation was the original grant awardee and upon their discontinuation as a standalone business entity, Navistar assumed the role of principal investigator. The intent of the effort, as part of the American Recovery and Reinvestment Act (ARRA) was to produce zero emission vehicles that could meet the needs of the marketplace while reducing carbon emissions to zero. This effort was predicated upon the assumption that concurrent development activities in the lithiummore » ion battery industry investigations would significantly increase their production volumes thus leading to substantial reductions in their manufacturing costs. As a result of this development effort much was learned about the overall system compatibility between the electric motor, battery pack, and charging capabilities. The original system was significantly revised and improved during the execution of this development effort. The overall approach that was chosen was to utilize a British zero emissions, class 2 truck that had been developed for their market, homologate it and modify it to meet the product requirements as specified in the grant details. All of these specific goals were achieved. During the course of marketing and selling the product valuable information was obtained as relates to customer expectations, price points, and product performance expectations, specifically those customer expectations about range requirements in urban delivery situations. While the grant requirements specified a range of 100 miles on a single charge, actual customer usage logs indicate a range of 40 miles or less is typical for their applications. The price point, primarily due to battery pack costs, was significantly higher than the mass market could bear. From Navistar’s and the overall industry’s perspective, valuable insights and lessons into this all-electric vehicle propulsion were gained during the performance of this effort and can be revisited when battery chemistry and technology advance to the point of more suitable economic viability. Additionally, another goal of the ARRA act and this specific grant was to manufacture the product in the, at that time, economically depressed Northwest Indiana area. Navistar chose a location in Wakarusa, Indiana which fulfilled this requirement. Navistar was and continues to be committed to alternative fuel and propulsion options as an industry leader in the medium and heavy duty truck industry.« less

The role of HIV integration in viral persistence: no more whistling past the proviral graveyard

PubMed Central

Maldarelli, Frank

2016-01-01

A substantial research effort has been directed to identifying strategies to eradicate or control HIV infection without a requirement for combination antiretroviral therapy (cART). A number of obstacles prevent HIV eradication, including low-level viral persistence during cART, long-term persistence of HIV-infected cells, and latent infection of resting CD4+ T cells. Mechanisms of persistence remain uncertain, but integration of the provirus into the host genome represents a central event in replication and pathogenesis of all retroviruses, including HIV. Analysis of HIV proviruses in CD4+ lymphocytes from individuals after prolonged cART revealed that a substantial proportion of the infected cells that persist have undergone clonal expansion and frequently have proviruses integrated in genes associated with regulation of cell growth. These data suggest that integration may influence persistence and clonal expansion of HIV-infected cells after cART is introduced, and these processes may represent key mechanisms for HIV persistence. Determining the diversity of host genes with integrants in HIV-infected cells that persist for prolonged periods may yield useful information regarding pathways by which infected cells persist for prolonged periods. Moreover, many integrants are defective, and new studies are required to characterize the role of clonal expansion in the persistence of replication-competent HIV. PMID:26829624

Sensor Web and Intelligent Sensors for Earth Science Applications

NASA Technical Reports Server (NTRS)

Habib, Shahid

2002-01-01

There is a significant interest in the Earth Science remote sensing community in substantially increasing the number of observations relative to the current frequency of collection. The obvious reason for such a push is to improve the temporal and surface coverage of measurements. However, there is little analysis available in terms of benefits, costs and optimized set of sensors needed to make these necessary observations. This is a complex problem that should be carefully studied and balanced over many boundaries. For example, the question of technology maturity versus users' desire for obtaining additional measurements is noncongruent. This is further complicated by the limitations of the laws of physics and the economic conditions. With the advent of advanced technology, it is anticipated that developments in spacecraft technology will enable advanced capabilities to become more affordable. However, specialized detector subsystems, and precision flying techniques may still require substantial innovation, development time and cost. Additionally, the space deployment scheme should also be given careful attention because of the high associated expense. Nonetheless, it is important to carefully examine the science priorities and steer the development efforts that can commensurate with the tangible requirements. This presentation will focus on a possible set of architectural concepts beneficial for future Earth science studies and research its and potential benefits.

Risk-based requirements management framework with applications to assurance cases

NASA Astrophysics Data System (ADS)

Feng, D.; Eyster, C.

The current regulatory approach for assuring device safety primarily focuses on compliance with prescriptive safety regulations and relevant safety standards. This approach, however, does not always lead to a safe system design even though safety regulations and standards have been met. In the medical device industry, several high profile recalls involving infusion pumps have prompted the regulatory agency to reconsider how device safety should be managed, reviewed and approved. An assurance case has been cited as a promising tool to address this growing concern. Assurance cases have been used in safety-critical systems for some time. Most assurance cases, if not all, in literature today are developed in an ad hoc fashion, independent from risk management and requirement development. An assurance case is a resource-intensive endeavor that requires additional effort and documentation from equipment manufacturers. Without a well-organized requirements infrastructure in place, such “ additional effort” can be substantial, to the point where the cost of adoption outweighs the benefit of adoption. In this paper, the authors present a Risk-Based Requirements and Assurance Management (RBRAM) methodology. The RBRAM is an elaborate framework that combines Risk-Based Requirements Management (RBRM) with assurance case methods. Such an integrated framework can help manufacturers leverage an existing risk management to present a comprehensive assurance case with minimal additional effort while providing a supplementary means to reexamine the integrity of the system design in terms of the mission objective. Although the example used is from the medical industry, the authors believe that the RBRAM methodology underlines the fundamental principle of risk management, and offers a simple, yet effective framework applicable to aerospace industry, perhaps, to any industry.

Cigarette smoking. Health effects and cessation strategies.

PubMed

Sachs, D P

1986-05-01

During the last 15 years substantial advances in the fields of analytical chemistry, behavioral pharmacology, neurologic sciences, and the behavioral sciences have produced new understanding and insight into why people smoke and how they can stop. These fundamental research efforts have now produced treatment strategies that have objectively documented success rates and that the physician can now implement in his office. Impressive as current results can be, when the physician is willing to spend appropriate and necessary time, effort, and energy, current research indicates that our basic neurochemical understanding of cigarette smoking should improve substantially and lead to even more effective treatment interventions in the next 10 years.

A seabird monitoring program for the North Pacific

USGS Publications Warehouse

Hatcher, S.A.; Kaiser, G.W.; Kondratyev, Alexander V.; Byrd, G.V.

1994-01-01

Seabird monitoring is the accumulation of time series data on any aspect of seabird distribution, abundance, demography, or behavior. Typical studies include annual or less frequent measures of numbers or productivity; less commonly, the focus is on marine habitat use, phenology, food habits, or survival. The key requirement is that observations are replicated over time and made with sufficient precision and accuracy to permit the meaningful analysis of variability and trends. Along the Pacific coast of North America, seabird monitoring has consumed substantial amounts of public funding since the early 1970s. The effort has been largely uncoordinated among the many entities involved, including provincial, state, and federal agencies, some private organizations, university faculty, and students. We reaffirm the rationale for monitoring seabirds, review briefly the nature and accomplishments of the existing effort, and suggest actions needed to improve the effectiveness of seabird monitoring in the Pacific. In particular, we propose and describe a comprehensive Seabird Monitoring Database designed specifically to work with observations on seabird population parameters that are replicated over time.

Big Data Technologies: New Opportunities for Diabetes Management.

PubMed

Bellazzi, Riccardo; Dagliati, Arianna; Sacchi, Lucia; Segagni, Daniele

2015-04-24

The so-called big data revolution provides substantial opportunities to diabetes management. At least 3 important directions are currently of great interest. First, the integration of different sources of information, from primary and secondary care to administrative information, may allow depicting a novel view of patient's care processes and of single patient's behaviors, taking into account the multifaceted nature of chronic care. Second, the availability of novel diabetes technologies, able to gather large amounts of real-time data, requires the implementation of distributed platforms for data analysis and decision support. Finally, the inclusion of geographical and environmental information into such complex IT systems may further increase the capability of interpreting the data gathered and extract new knowledge from them. This article reviews the main concepts and definitions related to big data, it presents some efforts in health care, and discusses the potential role of big data in diabetes care. Finally, as an example, it describes the research efforts carried on in the MOSAIC project, funded by the European Commission. © 2015 Diabetes Technology Society.

Big Data Technologies

PubMed Central

Bellazzi, Riccardo; Dagliati, Arianna; Sacchi, Lucia; Segagni, Daniele

2015-01-01

The so-called big data revolution provides substantial opportunities to diabetes management. At least 3 important directions are currently of great interest. First, the integration of different sources of information, from primary and secondary care to administrative information, may allow depicting a novel view of patient’s care processes and of single patient’s behaviors, taking into account the multifaceted nature of chronic care. Second, the availability of novel diabetes technologies, able to gather large amounts of real-time data, requires the implementation of distributed platforms for data analysis and decision support. Finally, the inclusion of geographical and environmental information into such complex IT systems may further increase the capability of interpreting the data gathered and extract new knowledge from them. This article reviews the main concepts and definitions related to big data, it presents some efforts in health care, and discusses the potential role of big data in diabetes care. Finally, as an example, it describes the research efforts carried on in the MOSAIC project, funded by the European Commission. PMID:25910540

Automated Performance Prediction of Message-Passing Parallel Programs

NASA Technical Reports Server (NTRS)

Block, Robert J.; Sarukkai, Sekhar; Mehra, Pankaj; Woodrow, Thomas S. (Technical Monitor)

1995-01-01

The increasing use of massively parallel supercomputers to solve large-scale scientific problems has generated a need for tools that can predict scalability trends of applications written for these machines. Much work has been done to create simple models that represent important characteristics of parallel programs, such as latency, network contention, and communication volume. But many of these methods still require substantial manual effort to represent an application in the model's format. The NIK toolkit described in this paper is the result of an on-going effort to automate the formation of analytic expressions of program execution time, with a minimum of programmer assistance. In this paper we demonstrate the feasibility of our approach, by extending previous work to detect and model communication patterns automatically, with and without overlapped computations. The predictions derived from these models agree, within reasonable limits, with execution times of programs measured on the Intel iPSC/860 and Paragon. Further, we demonstrate the use of MK in selecting optimal computational grain size and studying various scalability metrics.

Old adults perform activities of daily living near their maximal capabilities.

PubMed

Hortobágyi, Tibor; Mizelle, Chris; Beam, Stacey; DeVita, Paul

2003-05-01

Old adults' ability to execute activities of daily living (ADLs) declines with age. One possible reason for this decline is that the execution of customary motor tasks requires a substantially greater effort in old compared with young adults relative to their available maximal capacity. We tested the hypothesis that the relative effort (i.e., the percentage of joint moment relative to maximal joint moment) to execute ADLs is higher in old adults compared with young adults. Healthy young adults (n = 13; mean age, 22 years) and old adults (n = 14; mean age, 74 years) ascended and descended stairs and rose from a chair and performed maximal-effort isometric supine leg press. Using inverse dynamics analysis, we determined knee joint moments in ADLs and computed relative effort. Compared with young adults, old adults had 60% lower maximal leg press moments, 53% slower knee angular velocity at peak torque, and 27% lower knee joint moments in the ADLs (all p <.05). Relative effort in ascent was 54% (SD +/- 16%) and 78% (+/-20%) in young and old adults, respectively; in descent, it was 42% (+/-20%) and 88% (+/-43%); and in chair rise, it was 42% (+/-19%) and 80% (+/-34%) (all p <.05). The relative electromyographic activity of the vastus lateralis and the coactivity of the biceps femoris associated with this relative effort were, respectively, 2- and 1.6-fold greater in old compared with young adults in the 3 ADLs (p <.05). For healthy old adults, the difficulty that arises while performing ADLs may be due more to working at a higher level of effort relative to their maximum capability than to the absolute functional demands imposed by the task.

40 CFR 300.320 - General pattern of response.

Code of Federal Regulations, 2010 CFR

2010-07-01

...., substantial threat to the public health or welfare of the United States, worst case discharge) of the... private party efforts, and where the discharge does not pose a substantial threat to the public health or... 40 Protection of Environment 27 2010-07-01 2010-07-01 false General pattern of response. 300.320...

Extracellular space preservation aids the connectomic analysis of neural circuits

PubMed Central

Pallotto, Marta; Watkins, Paul V; Fubara, Boma; Singer, Joshua H; Briggman, Kevin L

2015-01-01

Dense connectomic mapping of neuronal circuits is limited by the time and effort required to analyze 3D electron microscopy (EM) datasets. Algorithms designed to automate image segmentation suffer from substantial error rates and require significant manual error correction. Any improvement in segmentation error rates would therefore directly reduce the time required to analyze 3D EM data. We explored preserving extracellular space (ECS) during chemical tissue fixation to improve the ability to segment neurites and to identify synaptic contacts. ECS preserved tissue is easier to segment using machine learning algorithms, leading to significantly reduced error rates. In addition, we observed that electrical synapses are readily identified in ECS preserved tissue. Finally, we determined that antibodies penetrate deep into ECS preserved tissue with only minimal permeabilization, thereby enabling correlated light microscopy (LM) and EM studies. We conclude that preservation of ECS benefits multiple aspects of the connectomic analysis of neural circuits. DOI: http://dx.doi.org/10.7554/eLife.08206.001 PMID:26650352

Excess plutonium disposition: The deep borehole option

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ferguson, K.L.

1994-08-09

This report reviews the current status of technologies required for the disposition of plutonium in Very Deep Holes (VDH). It is in response to a recent National Academy of Sciences (NAS) report which addressed the management of excess weapons plutonium and recommended three approaches to the ultimate disposition of excess plutonium: (1) fabrication and use as a fuel in existing or modified reactors in a once-through cycle, (2) vitrification with high-level radioactive waste for repository disposition, (3) burial in deep boreholes. As indicated in the NAS report, substantial effort would be required to address the broad range of issues relatedmore » to deep bore-hole emplacement. Subjects reviewed in this report include geology and hydrology, design and engineering, safety and licensing, policy decisions that can impact the viability of the concept, and applicable international programs. Key technical areas that would require attention should decisions be made to further develop the borehole emplacement option are identified.« less

Fault Tree Analysis.

PubMed

McElroy, Lisa M; Khorzad, Rebeca; Rowe, Theresa A; Abecassis, Zachary A; Apley, Daniel W; Barnard, Cynthia; Holl, Jane L

The purpose of this study was to use fault tree analysis to evaluate the adequacy of quality reporting programs in identifying root causes of postoperative bloodstream infection (BSI). A systematic review of the literature was used to construct a fault tree to evaluate 3 postoperative BSI reporting programs: National Surgical Quality Improvement Program (NSQIP), Centers for Medicare and Medicaid Services (CMS), and The Joint Commission (JC). The literature review revealed 699 eligible publications, 90 of which were used to create the fault tree containing 105 faults. A total of 14 identified faults are currently mandated for reporting to NSQIP, 5 to CMS, and 3 to JC; 2 or more programs require 4 identified faults. The fault tree identifies numerous contributing faults to postoperative BSI and reveals substantial variation in the requirements and ability of national quality data reporting programs to capture these potential faults. Efforts to prevent postoperative BSI require more comprehensive data collection to identify the root causes and develop high-reliability improvement strategies.

5 CFR 550.183 - Substantial hours requirement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Substantial hours requirement. 550.183 Section 550.183 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.183 Substantial hours requirement. (a...

5 CFR 550.183 - Substantial hours requirement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Substantial hours requirement. 550.183 Section 550.183 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.183 Substantial hours requirement. (a...

5 CFR 550.183 - Substantial hours requirement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Substantial hours requirement. 550.183 Section 550.183 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.183 Substantial hours requirement. (a...

5 CFR 550.183 - Substantial hours requirement.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Substantial hours requirement. 550.183 Section 550.183 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.183 Substantial hours requirement. (a...

The Database Query Support Processor (QSP)

NASA Technical Reports Server (NTRS)

1993-01-01

The number and diversity of databases available to users continues to increase dramatically. Currently, the trend is towards decentralized, client server architectures that (on the surface) are less expensive to acquire, operate, and maintain than information architectures based on centralized, monolithic mainframes. The database query support processor (QSP) effort evaluates the performance of a network level, heterogeneous database access capability. Air Force Material Command's Rome Laboratory has developed an approach, based on ANSI standard X3.138 - 1988, 'The Information Resource Dictionary System (IRDS)' to seamless access to heterogeneous databases based on extensions to data dictionary technology. To successfully query a decentralized information system, users must know what data are available from which source, or have the knowledge and system privileges necessary to find out this information. Privacy and security considerations prohibit free and open access to every information system in every network. Even in completely open systems, time required to locate relevant data (in systems of any appreciable size) would be better spent analyzing the data, assuming the original question was not forgotten. Extensions to data dictionary technology have the potential to more fully automate the search and retrieval for relevant data in a decentralized environment. Substantial amounts of time and money could be saved by not having to teach users what data resides in which systems and how to access each of those systems. Information describing data and how to get it could be removed from the application and placed in a dedicated repository where it belongs. The result simplified applications that are less brittle and less expensive to build and maintain. Software technology providing the required functionality is off the shelf. The key difficulty is in defining the metadata required to support the process. The database query support processor effort will provide quantitative data on the amount of effort required to implement an extended data dictionary at the network level, add new systems, adapt to changing user needs, and provide sound estimates on operations and maintenance costs and savings.

Emerald ash borer invasion of North America: history, biology, ecology, impacts, and management.

PubMed

Herms, Daniel A; McCullough, Deborah G

2014-01-01

Since its accidental introduction from Asia, emerald ash borer (EAB), Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), has killed millions of ash trees in North America. As it continues to spread, it could functionally extirpate ash with devastating economic and ecological impacts. Little was known about EAB when it was first discovered in North America in 2002, but substantial advances in understanding of EAB biology, ecology, and management have occurred since. Ash species indigenous to China are generally resistant to EAB and may eventually provide resistance genes for introgression into North American species. EAB is characterized by stratified dispersal resulting from natural and human-assisted spread, and substantial effort has been devoted to the development of survey methods. Early eradication efforts were abandoned largely because of the difficulty of detecting and delineating infestations. Current management is focused on biological control, insecticide protection of high-value trees, and integrated efforts to slow ash mortality.

Summary of NR Program Prometheus Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

J Ashcroft; C Eshelman

2006-02-08

The Naval Reactors Program led work on the development of a reactor plant system for the Prometheus space reactor program. The work centered on a 200 kWe electric reactor plant with a 15-20 year mission applicable to nuclear electric propulsion (NEP). After a review of all reactor and energy conversion alternatives, a direct gas Brayton reactor plant was selected for further development. The work performed subsequent to this selection included preliminary nuclear reactor and reactor plant design, development of instrumentation and control techniques, modeling reactor plant operational features, development and testing of core and plant material options, and development ofmore » an overall project plan. Prior to restructuring of the program, substantial progress had been made on defining reference plant operating conditions, defining reactor mechanical, thermal and nuclear performance, understanding the capabilities and uncertainties provided by material alternatives, and planning non-nuclear and nuclear system testing. The mission requirements for the envisioned NEP missions cannot be accommodated with existing reactor technologies. Therefore concurrent design, development and testing would be needed to deliver a functional reactor system. Fuel and material performance beyond the current state of the art is needed. There is very little national infrastructure available for fast reactor nuclear testing and associated materials development and testing. Surface mission requirements may be different enough to warrant different reactor design approaches and development of a generic multi-purpose reactor requires substantial sacrifice in performance capability for each mission.« less

Community prevention coalition context and capacity assessment: Comparing the United States and Mexico

PubMed Central

Brown, Louis D.; Chilenski, Sarah Meyer; Ramos, Rebeca; Gallegos, Nora; Feinberg, Mark E.

2015-01-01

Effective planning for community health partnerships requires understanding how initial readiness—that is, contextual factors and capacity-- influence implementation of activities and programs. This study compares the context and capacity of drug and violence prevention coalitions in Mexico to those in the United States. Measures of coalition context include community problems, community leadership style, and sense of community. Measures of coalition capacity include the existence of collaborative partnerships and coalition champions. The assessment was completed by 195 members of 9 coalitions in Mexico and 139 members of 7 coalitions in the United States. Psychometric analyses indicate the measures have moderate to strong internal consistency, along with good convergent and discriminant validity in both settings. Results indicate that members of Mexican coalitions perceive substantially more serious community problems, especially with respect to education, law enforcement, and access to alcohol and drugs. Compared to respondents in the U.S., Mexican respondents perceive sense of community to be weaker and that prevention efforts are not as valued by the population where the coalitions are located. The Mexican coalitions appear to be operating in a substantially more challenging environment for the prevention of violence and substance use. Their ability to manage these challenges will likely play a large role in determining whether they are successful in their prevention efforts. The context and capacity assessment is a valuable tool coalitions can use to identify and address initial barriers to success. PMID:26205249

Community Prevention Coalition Context and Capacity Assessment: Comparing the United States and Mexico.

PubMed

Brown, Louis D; Chilenski, Sarah M; Ramos, Rebeca; Gallegos, Nora; Feinberg, Mark E

2016-04-01

Effective planning for community health partnerships requires understanding how initial readiness-that is, contextual factors and capacity-influences implementation of activities and programs. This study compares the context and capacity of drug and violence prevention coalitions in Mexico to those in the United States. Measures of coalition context include community problems, community leadership style, and sense of community. Measures of coalition capacity include the existence of collaborative partnerships and coalition champions. The assessment was completed by 195 members of 9 coalitions in Mexico and 139 members of 7 coalitions in the United States. Psychometric analyses indicate the measures have moderate to strong internal consistency, along with good convergent and discriminant validity in both settings. Results indicate that members of Mexican coalitions perceive substantially more serious community problems, especially with respect to education, law enforcement, and access to alcohol and drugs. Compared to respondents in the United States, Mexican respondents perceive sense of community to be weaker and that prevention efforts are not as valued by the population where the coalitions are located. The Mexican coalitions appear to be operating in a substantially more challenging environment for the prevention of violence and substance use. Their ability to manage these challenges will likely play a large role in determining whether they are successful in their prevention efforts. The context and capacity assessment is a valuable tool that coalitions can use in order to identify and address initial barriers to success. © 2015 Society for Public Health Education.

Microwave thermal emission from periodic surfaces

NASA Technical Reports Server (NTRS)

Kong, J. A.; Lin, S. L.; Chuang, S. L.

1984-01-01

The emissivity of a periodic surface is calculated from one minus the reflectivity by using the reciprocity principle. The reflectivity consists of the sum of all scattered power as determined from the modal theory which obeys both the principle of reciprocity and the principle of energy conservation. The theoretical results are matched to experimental data obtained from brightness temperature measurements as functions of viewing angle for soil moisture in plowed fields. The threshold phenomenon with regard to the appearing and disappearing of modes in their contributions to the scattered field amplitudes is discussed in connection with the theoretical results. It is shown that this approach for calculating the emissivity greatly reduces computational efforts by requiring substantially smaller matrix sizes.

Combined AIE/EBE/GMRES approach to incompressible flows. [Adaptive Implicit-Explicit/Grouped Element-by-Element/Generalized Minimum Residuals

NASA Technical Reports Server (NTRS)

Liou, J.; Tezduyar, T. E.

1990-01-01

Adaptive implicit-explicit (AIE), grouped element-by-element (GEBE), and generalized minimum residuals (GMRES) solution techniques for incompressible flows are combined. In this approach, the GEBE and GMRES iteration methods are employed to solve the equation systems resulting from the implicitly treated elements, and therefore no direct solution effort is involved. The benchmarking results demonstrate that this approach can substantially reduce the CPU time and memory requirements in large-scale flow problems. Although the description of the concepts and the numerical demonstration are based on the incompressible flows, the approach presented here is applicable to larger class of problems in computational mechanics.

Potential benefits for propfan technology on derivatives of future short- to medium-range transport aircraft

NASA Technical Reports Server (NTRS)

Goldsmith, I. M.; Bowles, J. V.

1980-01-01

It is noted that several NASA-sponsored studies have identified a substantial potential fuel savings for high subsonic speed aircraft utilizing the propfan concept compared to the equivalent technology turbofan aircraft. Attention is given to a feasibility study for propfan-powered short- to medium-haul commercial transport aircraft conducted to evaluate potential fuel savings and identify critical technology requirements using the latest propfan performance data. An analysis is made of the design and performance characteristics of a wing-mounted and two-aft-mounted derivative propfan aircraft configurations, based on a DC-9 Super 80 airframe, which are compared to the baseline turbofan design. Finally, recommendations for further research efforts are also made.

Investigations related to evaluation of ultramicrofluorometer

NASA Technical Reports Server (NTRS)

Whitcomb, B.

1981-01-01

High resolution emission and excitation fluorescent spectra were obtained for several samples in an effort to determine the optimum operational design for the instrument. The instrument was used to determine the required nature of a sample which could be detected, and in so doing, several different sample preparation techniques were considered. Numerous experiments were performed to determine the capabilities of the instrument with regard to the detection of suitably prepared virus specimens. Significant results were obtained in several areas. The fluorescent spectra indicated that substantial changes in the laser might be used advantageously to greatly improve the performance of the instrument. In the existing configuration, the instrument was shown to be capable of detecting the presence of suitably prepared virus samples.

Financing prevention: opportunities for economic analysis across the translational research cycle.

PubMed

Crowley, D Max; Jones, Damon

2016-03-01

Prevention advocates often make the case that preventive intervention not only improves public health and welfare but also can save public resources. Increasingly, evidence-based policy efforts considering prevention are focusing on how programs can save taxpayer resources from reduced burden on health, criminal justice, and social service systems. Evidence of prevention's return has begun to draw substantial investments from the public and private sector. Yet, translating prevention effectiveness into economic impact requires specific economic analyses to be employed across the stages of translational research. This work discusses the role of economic analysis in prevention science and presents key translational research opportunities to meet growing demand for estimates of prevention's economic and fiscal impact.

Fabrication of a Bronze Age Sword using Ancient Techniques

NASA Astrophysics Data System (ADS)

Sapiro, David; Webler, Bryan

2016-12-01

A khopesh was cast and forged for the TMS 2016 Bladesmithing Symposium. The khopesh was the first sword style, originating during the Bronze Age in the Near East. The manufacturing process used in this study closely followed Bronze Age techniques to determine the plausibility of open mold casting coupled with cold work and annealing cycles. Forging and annealing cycles substantially increased blade strength and diminished intergranular δ-phase inclusions. While a functional blade was not completed due to casting defects, the process gives valuable insight into the effort required to fabricate a khopesh during the Bronze Age. Forging and annealing cycles following casting were necessary to produce the mechanical properties desired in a sword.

Norovirus

PubMed Central

Robilotti, Elizabeth; Deresinski, Stan

2015-01-01

SUMMARY Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen that causes substantial morbidity across both health care and community settings. Several factors enhance the transmissibility of norovirus, including the small inoculum required to produce infection (<100 viral particles), prolonged viral shedding, and its ability to survive in the environment. In this review, we describe the basic virology and immunology of noroviruses, the clinical disease resulting from infection and its diagnosis and management, as well as host and pathogen factors that complicate vaccine development. Additionally, we discuss overall epidemiology, infection control strategies, and global reporting efforts aimed at controlling this worldwide cause of acute gastroenteritis. Prompt implementation of infection control measures remains the mainstay of norovirus outbreak management. PMID:25567225

Mind the Gap: Race\\Ethnic and Socioeconomic Disparities in Obesity

PubMed Central

Reither, Eric N.

2016-01-01

Race/ethnic and socioeconomic status (SES) disparities in obesity are substantial and may widen in the future. We review seven potential mechanisms that recent research has used to explain obesity disparities. Those seven mechanisms fall into three broad groups—health behaviors, biological and developmental factors, and the social environment—which incorporate both proximate and upstream determinants of obesity disparities. Efforts to reduce the prevalence of obesity in the U.S. population and to close race/ethnic and SES disparities in obesity will likely require the use of multifaceted interventions that target multiple mechanisms simultaneously. Unfortunately, relatively few of the mechanisms reviewed herein have been tested in an intervention framework. PMID:26377742

Uncertainty Analysis via Failure Domain Characterization: Polynomial Requirement Functions

NASA Technical Reports Server (NTRS)

Crespo, Luis G.; Munoz, Cesar A.; Narkawicz, Anthony J.; Kenny, Sean P.; Giesy, Daniel P.

2011-01-01

This paper proposes an uncertainty analysis framework based on the characterization of the uncertain parameter space. This characterization enables the identification of worst-case uncertainty combinations and the approximation of the failure and safe domains with a high level of accuracy. Because these approximations are comprised of subsets of readily computable probability, they enable the calculation of arbitrarily tight upper and lower bounds to the failure probability. A Bernstein expansion approach is used to size hyper-rectangular subsets while a sum of squares programming approach is used to size quasi-ellipsoidal subsets. These methods are applicable to requirement functions whose functional dependency on the uncertainty is a known polynomial. Some of the most prominent features of the methodology are the substantial desensitization of the calculations from the uncertainty model assumed (i.e., the probability distribution describing the uncertainty) as well as the accommodation for changes in such a model with a practically insignificant amount of computational effort.

Uncertainty Analysis via Failure Domain Characterization: Unrestricted Requirement Functions

NASA Technical Reports Server (NTRS)

Crespo, Luis G.; Kenny, Sean P.; Giesy, Daniel P.

2011-01-01

This paper proposes an uncertainty analysis framework based on the characterization of the uncertain parameter space. This characterization enables the identification of worst-case uncertainty combinations and the approximation of the failure and safe domains with a high level of accuracy. Because these approximations are comprised of subsets of readily computable probability, they enable the calculation of arbitrarily tight upper and lower bounds to the failure probability. The methods developed herein, which are based on nonlinear constrained optimization, are applicable to requirement functions whose functional dependency on the uncertainty is arbitrary and whose explicit form may even be unknown. Some of the most prominent features of the methodology are the substantial desensitization of the calculations from the assumed uncertainty model (i.e., the probability distribution describing the uncertainty) as well as the accommodation for changes in such a model with a practically insignificant amount of computational effort.

Operation and design selection of high temperature superconducting magnetic bearings

NASA Astrophysics Data System (ADS)

Werfel, F. N.; Floegel-Delor, U.; Riedel, T.; Rothfeld, R.; Wippich, D.; Goebel, B.

2004-10-01

Axial and radial high temperature superconducting (HTS) magnetic bearings are evaluated by their parameters. Journal bearings possess advantages over thrust bearings. High magnetic gradients in a multi-pole permanent magnet (PM) configuration, the surrounding melt textured YBCO stator and adequate designs are the key features for increasing the overall bearing stiffness. The gap distance between rotor and stator determines the specific forces and has a strong impact on the PM rotor design. We report on the designing, building and measuring of a 200 mm prototype 100 kg HTS bearing with an encapsulated and thermally insulated melt textured YBCO ring stator. The encapsulation requires a magnetically large-gap (4-5 mm) operation but reduces the cryogenic effort substantially. The bearing requires 3 l of LN2 for cooling down, and about 0.2 l LN2 h-1 under operation. This is a dramatic improvement of the efficiency and in the practical usage of HTS magnetic bearings.

Ignaz Semmelweis redux?

PubMed

Raemer, Daniel B

2014-06-01

The story of Ignaz Semmelweis suggests a lesson to beware of unintended consequences, especially with in situ simulation. In situ simulation offers many important advantages over center-based simulation such as learning about the real setting, putting participants at ease, saving travel time, minimizing space requirements, involving patients and families. Some substantial disadvantages include frequent distractions, lack of privacy, logistics of setup, availability of technology, and supply costs. Importantly, in situ simulation amplifies some of the safety hazards of simulation itself including maintaining control of simulated medications and equipment, limiting the use of valuable hospital resources, preventing incorrect learning from simulation shortcuts, and profoundly upsetting patients and their families. Mitigating these hazards by labeling effectively, publishing policies and procedures, securing simulation supplies and equipment, educating simulation staff, and informing participants of the risks are all methods that may lessen the potential for an accident. Each requires a serious effort of analysis, design, and implementation.

Implementing and integrating a clinically driven electronic medical record for radiation oncology in a large medical enterprise.

PubMed

Kirkpatrick, John P; Light, Kim L; Walker, Robyn M; Georgas, Debra L; Antoine, Phillip A; Clough, Robert W; Cozart, Heidi B; Yin, Fang-Fang; Yoo, Sua; Willett, Christopher G

2013-01-01

While our department is heavily invested in computer-based treatment planning, we historically relied on paper-based charts for management of Radiation Oncology patients. In early 2009, we initiated the process of conversion to an electronic medical record (EMR) eliminating the need for paper charts. Key goals included the ability to readily access information wherever and whenever needed, without compromising safety, treatment quality, confidentiality, or productivity. In February, 2009, we formed a multi-disciplinary team of Radiation Oncology physicians, nurses, therapists, administrators, physicists/dosimetrists, and information technology (IT) specialists, along with staff from the Duke Health System IT department. The team identified all existing processes and associated information/reports, established the framework for the EMR system and generated, tested and implemented specific EMR processes. Two broad classes of information were identified: information which must be readily accessed by anyone in the health system versus that used solely within the Radiation Oncology department. Examples of the former are consultation reports, weekly treatment check notes, and treatment summaries; the latter includes treatment plans, daily therapy records, and quality assurance reports. To manage the former, we utilized the enterprise-wide system, which required an intensive effort to design and implement procedures to export information from Radiation Oncology into that system. To manage "Radiation Oncology" data, we used our existing system (ARIA, Varian Medical Systems.) The ability to access both systems simultaneously from a single workstation (WS) was essential, requiring new WS and modified software. As of January, 2010, all new treatments were managed solely with an EMR. We find that an EMR makes information more widely accessible and does not compromise patient safety, treatment quality, or confidentiality. However, compared to paper charts, time required by clinicians to access/enter patient information has substantially increased. While productivity is improving with experience, substantial growth will require better integration of the system components, decreased access times, and improved user interfaces. $127K was spent on new hardware and software; elimination of paper yields projected savings of $21K/year. One year after conversion to an EMR, more than 90% of department staff favored the EMR over the previous paper charts. Successful implementation of a Radiation Oncology EMR required not only the effort and commitment of all functions of the department, but support from senior health system management, corporate IT, and vendors. Realization of the full benefits of an EMR will require experience, faster/better integrated software, and continual improvement in underlying clinical processes.

Group-effort Applied Research: Expanding Opportunities for Undergraduate Research through Original, Class-Based Research Projects

ERIC Educational Resources Information Center

Moore, Sean D.; Teter, Ken

2014-01-01

Undergraduate research clearly enriches the educational development of participating students, but these experiences are limited by the inherent inefficiency of the standard one student-one mentor model for undergraduate research. Group-effort applied research (GEAR) was developed as a strategy to provide substantial numbers of undergraduates with…

49 CFR 384.301 - Substantial compliance-general requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... personnel), and enforcement practices. (b)(1) A State must come into substantial compliance with the... come into substantial compliance with 49 CFR 383.123 not later than September 30, 2006. (c) A State must come into substantial compliance with the requirements of subpart B of this part in effect as of...

49 CFR 384.301 - Substantial compliance-general requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... personnel), and enforcement practices. (b)(1) A State must come into substantial compliance with the... come into substantial compliance with 49 CFR 383.123 not later than September 30, 2006. (c) A State must come into substantial compliance with the requirements of subpart B of this part in effect as of...

49 CFR 384.301 - Substantial compliance-general requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... personnel), and enforcement practices. (b)(1) A State must come into substantial compliance with the... come into substantial compliance with 49 CFR 383.123 not later than September 30, 2006. (c) A State must come into substantial compliance with the requirements of subpart B of this part in effect as of...

49 CFR 384.301 - Substantial compliance-general requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... personnel), and enforcement practices. (b)(1) A State must come into substantial compliance with the... come into substantial compliance with 49 CFR 383.123 not later than September 30, 2006. (c) A State must come into substantial compliance with the requirements of subpart B of this part in effect as of...

Determinants of individual and group performance

NASA Technical Reports Server (NTRS)

Helmreich, Robert L.

1986-01-01

A broad exploration of individual and group/organizational factors that influence performance in demanding environments such as space and air transport was undertaken. Primary efforts were directed toward defining critical issues, developing new methodologies for the assessment of performance in such environments, and developing new measures of personality and attitudes as predictors of performance. Substantial clarification of relevant issues for research and validation was achieved. A reliable instrument to assess crewmembers' attitudes regarding crew coordination and flightdeck management was validated. Major efforts in data collection to validate concepts were initiated. The results suggest that substantial improvements can be made in the prediction of performance and in the selection of crewmembers for aviation and space.

Computerized summary scoring: crowdsourcing-based latent semantic analysis.

PubMed

Li, Haiying; Cai, Zhiqiang; Graesser, Arthur C

2017-11-03

In this study we developed and evaluated a crowdsourcing-based latent semantic analysis (LSA) approach to computerized summary scoring (CSS). LSA is a frequently used mathematical component in CSS, where LSA similarity represents the extent to which the to-be-graded target summary is similar to a model summary or a set of exemplar summaries. Researchers have proposed different formulations of the model summary in previous studies, such as pregraded summaries, expert-generated summaries, or source texts. The former two methods, however, require substantial human time, effort, and costs in order to either grade or generate summaries. Using source texts does not require human effort, but it also does not predict human summary scores well. With human summary scores as the gold standard, in this study we evaluated the crowdsourcing LSA method by comparing it with seven other LSA methods that used sets of summaries from different sources (either experts or crowdsourced) of differing quality, along with source texts. Results showed that crowdsourcing LSA predicted human summary scores as well as expert-good and crowdsourcing-good summaries, and better than the other methods. A series of analyses with different numbers of crowdsourcing summaries demonstrated that the number (from 10 to 100) did not significantly affect performance. These findings imply that crowdsourcing LSA is a promising approach to CSS, because it saves human effort in generating the model summary while still yielding comparable performance. This approach to small-scale CSS provides a practical solution for instructors in courses, and also advances research on automated assessments in which student responses are expected to semantically converge on subject matter content.

42 CFR 418.66 - Condition of participation: Nursing services-Waiver of requirement that substantially all nursing...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Condition of participation: Nursing services-Waiver of requirement that substantially all nursing services be routinely provided directly by a hospice... Services § 418.66 Condition of participation: Nursing services—Waiver of requirement that substantially all...

42 CFR 418.66 - Condition of participation: Nursing services-Waiver of requirement that substantially all nursing...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Condition of participation: Nursing services-Waiver of requirement that substantially all nursing services be routinely provided directly by a hospice... Services § 418.66 Condition of participation: Nursing services—Waiver of requirement that substantially all...

49 CFR 384.301 - Substantial compliance-general requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... State must come into substantial compliance with the requirements of subpart B of this part in effect as..., not later than September 30, 2005. (2) Exception. A State must come into substantial compliance with 49 CFR 383.123 not later than September 30, 2006. (c) A State must come into substantial compliance...

Anisotropic path modeling to assess pedestrian-evacuation potential from Cascadia-related tsunamis in the US Pacific Northwest

USGS Publications Warehouse

Wood, Nathan J.; Schmidtlein, Mathew C.

2012-01-01

Recent disasters highlight the threat that tsunamis pose to coastal communities. When developing tsunami-education efforts and vertical-evacuation strategies, emergency managers need to understand how much time it could take for a coastal population to reach higher ground before tsunami waves arrive. To improve efforts to model pedestrian evacuations from tsunamis, we examine the sensitivity of least-cost-distance models to variations in modeling approaches, data resolutions, and travel-rate assumptions. We base our observations on the assumption that an anisotropic approach that uses path-distance algorithms and accounts for variations in land cover and directionality in slope is the most realistic of an actual evacuation landscape. We focus our efforts on the Long Beach Peninsula in Washington (USA), where a substantial residential and tourist population is threatened by near-field tsunamis related to a potential Cascadia subduction zone earthquake. Results indicate thousands of people are located in areas where evacuations to higher ground will be difficult before arrival of the first tsunami wave. Deviations from anisotropic modeling assumptions substantially influence the amount of time likely needed to reach higher ground. Across the entire study, changes in resolution of elevation data has a greater impact on calculated travel times than changes in land-cover resolution. In particular areas, land-cover resolution had a substantial impact when travel-inhibiting waterways were not reflected in small-scale data. Changes in travel-speed parameters had a substantial impact also, suggesting the importance of public-health campaigns as a tsunami risk-reduction strategy.

20 CFR 229.85 - Substantial gainful activity by blind employee or child.

Code of Federal Regulations, 2011 CFR

2011-04-01

... substantial gainful activity that does not require skills or ability used in his or her previous work. However... in any type of substantial gainful activity which requires skills or abilities comparable to those of...

Evaluating the Potential Efficacy of Invasive Lionfish (Pterois volitans) Removals

PubMed Central

Barbour, Andrew B.; Allen, Michael S.; Frazer, Thomas K.; Sherman, Krista D.

2011-01-01

The lionfish, Pterois volitans (Linnaeus) and Pterois miles (Bennett), invasion of the Western Atlantic Ocean, Caribbean Sea and Gulf of Mexico has the potential to alter aquatic communities and represents a legitimate ecological concern. Several local removal programs have been initiated to control this invasion, but it is not known whether removal efforts can substantially reduce lionfish numbers to ameliorate these concerns. We used an age-structured population model to evaluate the potential efficacy of lionfish removal programs and identified critical data gaps for future studies. We used high and low estimates for uncertain parameters including: length at 50% vulnerability to harvest (Lvul), instantaneous natural mortality (M), and the Goodyear compensation ratio (CR). The model predicted an annual exploitation rate between 35 and 65% would be required to cause recruitment overfishing on lionfish populations for our baseline parameter estimates for M and CR (0.5 and 15). Lionfish quickly recovered from high removal rates, reaching 90% of unfished biomass six years after a 50-year simulated removal program. Quantifying lionfish natural mortality and the size-selective vulnerability to harvest are the most important knowledge gaps for future research. We suggest complete eradication of lionfish through fishing is unlikely, and substantial reduction of adult abundance will require a long-term commitment and may be feasible only in small, localized areas where annual exploitation can be intense over multiple consecutive years. PMID:21572951

Evaluating the potential efficacy of invasive lionfish (Pterois volitans) removals.

PubMed

Barbour, Andrew B; Allen, Micheal S; Allen, Michael S; Frazer, Thomas K; Sherman, Krista D

2011-05-10

The lionfish, Pterois volitans (Linnaeus) and Pterois miles (Bennett), invasion of the Western Atlantic Ocean, Caribbean Sea and Gulf of Mexico has the potential to alter aquatic communities and represents a legitimate ecological concern. Several local removal programs have been initiated to control this invasion, but it is not known whether removal efforts can substantially reduce lionfish numbers to ameliorate these concerns. We used an age-structured population model to evaluate the potential efficacy of lionfish removal programs and identified critical data gaps for future studies. We used high and low estimates for uncertain parameters including: length at 50% vulnerability to harvest (L(vul)), instantaneous natural mortality (M), and the Goodyear compensation ratio (CR). The model predicted an annual exploitation rate between 35 and 65% would be required to cause recruitment overfishing on lionfish populations for our baseline parameter estimates for M and CR (0.5 and 15). Lionfish quickly recovered from high removal rates, reaching 90% of unfished biomass six years after a 50-year simulated removal program. Quantifying lionfish natural mortality and the size-selective vulnerability to harvest are the most important knowledge gaps for future research. We suggest complete eradication of lionfish through fishing is unlikely, and substantial reduction of adult abundance will require a long-term commitment and may be feasible only in small, localized areas where annual exploitation can be intense over multiple consecutive years.

United Kingdom unveils ambitious air pollution plan

NASA Astrophysics Data System (ADS)

Warren, Matthew

2018-06-01

The U.K. government's new strategy to combat air pollution has drawn praise for its ambitious goals—and reservations about whether they will be achieved. Environmental scientists have applauded the aims of the Clean Air Strategy, which include substantially reducing the number of people breathing air containing high levels of fine particulates and curbing ammonia emissions from agriculture. But for now, the document, published as a draft for public consultation on 22 May, remains light on the specific policies that will help the country attain these goals. And although the government has said that with the new strategy it will go further than the European Union in tackling air pollution post-Brexit, scientists say major improvements to air quality will require a coordinated effort across Europe.

Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa

PubMed Central

Freeman, Esther E.; White, Richard G.; Bakker, Roel; Orroth, Kate K.; Weiss, Helen A.; Buvé, Anne; Hayes, Richard J.; Glynn, Judith R.

2009-01-01

Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75% for 10 years, reduced HIV incidence by 30–40% after 20 years (range 4–66%). Over 20 years, in most scenarios fewer than 100 vaccinations were required to avert one HIV infection. HSV2 vaccines could have a substantial impact on HIV incidence. Intensified efforts are needed to develop an effective HSV2 vaccine. PMID:19071187

Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa.

PubMed

Freeman, Esther E; White, Richard G; Bakker, Roel; Orroth, Kate K; Weiss, Helen A; Buvé, Anne; Hayes, Richard J; Glynn, Judith R

2009-02-05

Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75% for 10 years, reduced HIV incidence by 30-40% after 20 years (range 4-66%). Over 20 years, in most scenarios fewer than 100 vaccinations were required to avert one HIV infection. HSV2 vaccines could have a substantial impact on HIV incidence. Intensified efforts are needed to develop an effective HSV2 vaccine.

Modeling Global Ocean Biogeochemistry With Physical Data Assimilation: A Pragmatic Solution to the Equatorial Instability

NASA Astrophysics Data System (ADS)

Park, Jong-Yeon; Stock, Charles A.; Yang, Xiaosong; Dunne, John P.; Rosati, Anthony; John, Jasmin; Zhang, Shaoqing

2018-03-01

Reliable estimates of historical and current biogeochemistry are essential for understanding past ecosystem variability and predicting future changes. Efforts to translate improved physical ocean state estimates into improved biogeochemical estimates, however, are hindered by high biogeochemical sensitivity to transient momentum imbalances that arise during physical data assimilation. Most notably, the breakdown of geostrophic constraints on data assimilation in equatorial regions can lead to spurious upwelling, resulting in excessive equatorial productivity and biogeochemical fluxes. This hampers efforts to understand and predict the biogeochemical consequences of El Niño and La Niña. We develop a strategy to robustly integrate an ocean biogeochemical model with an ensemble coupled-climate data assimilation system used for seasonal to decadal global climate prediction. Addressing spurious vertical velocities requires two steps. First, we find that tightening constraints on atmospheric data assimilation maintains a better equatorial wind stress and pressure gradient balance. This reduces spurious vertical velocities, but those remaining still produce substantial biogeochemical biases. The remainder is addressed by imposing stricter fidelity to model dynamics over data constraints near the equator. We determine an optimal choice of model-data weights that removed spurious biogeochemical signals while benefitting from off-equatorial constraints that still substantially improve equatorial physical ocean simulations. Compared to the unconstrained control run, the optimally constrained model reduces equatorial biogeochemical biases and markedly improves the equatorial subsurface nitrate concentrations and hypoxic area. The pragmatic approach described herein offers a means of advancing earth system prediction in parallel with continued data assimilation advances aimed at fully considering equatorial data constraints.

Geomorphology and the Restoration Ecology of Salmon

NASA Astrophysics Data System (ADS)

Montgomery, D. R.

2005-05-01

Natural and anthropogenic influences on watershed processes affect the distribution and abundance of salmon across a wide range of spatial and temporal scales, from differences in species use and density between individual pools and riffles to regional patterns of threatened, endangered, and extinct runs. The specific impacts of human activities (e.g., mining, logging, and urbanization) vary among regions and watersheds, as well as between different channel reaches in the same watershed. Understanding of both disturbance history and key biophysical processes are important for diagnosing the nature and causes of differences between historical and contemporary fluvial and watershed conditions based on evaluation of both historical and spatial contexts. In order to be most effective, the contribution of geomorphologic insight to salmon recovery efforts requires both assessment protocols commensurate with providing adequate knowledge of historical and spatial context, and experienced practitioners well versed in adapting general theory to local settings. The historical record of salmon management in Europe, New England and the Pacific Northwest indicates that there is substantial need to incorporate geomorphic insights on the effects of changes in watershed processes on salmon habitat and salmon abundance into salmon recovery efforts.

Optimizing Resources for Trustworthiness and Scientific Impact of Domain Repositories

NASA Astrophysics Data System (ADS)

Lehnert, K.

2017-12-01

Domain repositories, i.e. data archives tied to specific scientific communities, are widely recognized and trusted by their user communities for ensuring a high level of data quality, enhancing data value, access, and reuse through a unique combination of disciplinary and digital curation expertise. Their data services are guided by the practices and values of the specific community they serve and designed to support the advancement of their science. Domain repositories need to meet user expectations for scientific utility in order to be successful, but they also need to fulfill the requirements for trustworthy repository services to be acknowledged by scientists, funders, and publishers as a reliable facility that curates and preserves data following international standards. Domain repositories therefore need to carefully plan and balance investments to optimize the scientific impact of their data services and user satisfaction on the one hand, while maintaining a reliable and robust operation of the repository infrastructure on the other hand. Staying abreast of evolving repository standards to certify as a trustworthy repository and conducting a regular self-assessment and certification alone requires resources that compete with the demands for improving data holdings or usability of systems. The Interdisciplinary Earth Data Alliance (IEDA), a data facility funded by the US National Science Foundation, operates repositories for geochemical, marine Geoscience, and Antarctic research data, while also maintaining data products (global syntheses) and data visualization and analysis tools that are of high value for the science community and have demonstrated considerable scientific impact. Balancing the investments in the growth and utility of the syntheses with resources required for certifcation of IEDA's repository services has been challenging, and a major self-assessment effort has been difficult to accommodate. IEDA is exploring a partnership model to share generic repository functions (e.g. metadata registration, long-term archiving) with other repositories. This could substantially reduce the effort of certification and allow effort to focus on the domain-specific data curation and value-added services.

Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?

PubMed

Auld, Sara C; Kasmar, Anne G; Dowdy, David W; Mathema, Barun; Gandhi, Neel R; Churchyard, Gavin J; Rustomjee, Roxana; Shah, N Sarita

2017-11-03

High rates of tuberculosis transmission are driving the ongoing global tuberculosis epidemic, and there is a pressing need for research focused on understanding and, ultimately, halting transmission. The ongoing tuberculosis-human immunodeficiency virus (HIV) coepidemic and rising rates of drug-resistant tuberculosis in parts of the world add further urgency to this work. Success in this research will require a concerted, multidisciplinary effort on the part of tuberculosis scientists, clinicians, programs, and funders and must span the research spectrum from biomedical sciences to the social sciences, public health, epidemiology, cost-effectiveness analyses, and operations research. Heterogeneity of tuberculosis disease, both among individual patients and among communities, poses a substantial challenge to efforts to interrupt transmission. As such, it is likely that effective interventions to stop transmission will require a combination of approaches that will vary across different epidemiologic settings. This research roadmap summarizes key gaps in our current understanding of transmission, as laid out in the preceding articles in this series. We also hope that it will be a call to action for the global tuberculosis community to make a sustained commitment to tuberculosis transmission science. Halting transmission today is an essential step on the path to end tuberculosis tomorrow. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

Development of Large-Scale Spacecraft Fire Safety Experiments

NASA Technical Reports Server (NTRS)

Ruff, Gary A.; Urban, David; Fernandez-Pello, A. Carlos; T'ien, James S.; Torero, Jose L.; Legros, Guillaume; Eigenbrod, Christian; Smirnov, Nickolay; Fujita, Osamu; Cowlard, Adam J.;

Future challenges in communication for promoting ORT--an overview.

PubMed

Dobe, M

2003-06-01

Oral rehydration therapy (ORT) is a cheap and simple intervention aimed to prevent mortality and morbidity associated with dehydration due to diarrhoea. ORT promotion strategies through programme communication, social mobilisation and social marketing, and advocacy efforts have yielded substantial improvement in the scenario. However, it has also taught us lessons and suggested changes in communication strategies to make the promotion efforts more effective in future.

20 CFR 229.85 - Substantial gainful activity by blind employee or child.

Code of Federal Regulations, 2010 CFR

2010-04-01

... THE RAILROAD RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Miscellaneous Deductions and... substantial gainful activity that does not require skills or ability used in his or her previous work. However... in any type of substantial gainful activity which requires skills or abilities comparable to those of...

Polio communication.

PubMed

Galaway, Michael

2005-12-01

Substantial investments are being made in the area of communication and social mobilisation to interrupt transmission of wild poliovirus. A number of organisations with active support from the Government of India and various state governments are implementing activities to raise awareness and encourage all families to immunise their children. A mass media campaign is the most recognised health promotion effort on media. Mass media efforts are being backed by intensive social mobilisation and interpersonal communication efforts in polio-endemic states. Advocacy and editorial media environment are key elements of the overall communication approach, creating a conducive environment for the polio programme.

Managing Multi-Center Recruitment in the PLCO Cancer Screening Trial.

PubMed

Gohagan, John K; Broski, Karen; Gren, Lisa H; Fouad, Mona N; Higgins, Darlene; Lappe, Karen; Ogden, Sheryl; Shambaugh, Vicki; Pinsky, Paul F; O'Brien, Barbara; Yurgalevich, Susan; Riley, Tom; Wright, Patrick; Prorok, Philip C

2015-01-01

There were significant recruitment challenges specific to the PLCO Cancer Screening Trial. Large numbers of participants were to be randomized from ten catchment areas nationwide within time and budgetary constraints. The eligible population was elderly and had to meet health and behavioral thresholds. Informed consent was required to participate and be randomized to screening for three cancers at periodic clinic visits or to a usual care arm that included no clinical visits. Consenting required special efforts to fully explain the trial and its potential scientific benefit to future patients with potentially no benefits but possible harms to PLCO participants. Participation would include continued follow-up for at least 13 years after randomization. Strong collaborative investments were required by the NCI and screening centers (SCs) to assure timely recruitment and appropriate racial participation. A trial-wide pilot phase tested recruitment and protocol follow through at SCs and produced a vanguard population of 11,406 participants. NCI announced the trial nationally in advance of the pilot and followed with an even more intense collaborative role with SCs for the main phase to facilitate trial-wide efficient and timely recruitment. Special efforts to enhance recruitment in the main phase included centralized and local monitoring of progress, cross-linking SCs to share experiences in problem solving, centralized training, substantial additional funding dedicated to recruitment and retention, including specialized programs for minority recruitment, obtaining national endorsement by the American Cancer Society, launching satellite recruitment and screening centers, including minority focused satellites, and adding a new SC dedicated to minority recruitment.

Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats

PubMed Central

Font, Laura; Mingote, Susana; Farrar, Andrew M.; Pereira, Mariana; Worden, Lila; Stopper, Colin; Port, Russell G.

2009-01-01

Rationale Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission reallocate their behavior away from food-reinforced activities that have high response requirements and instead select less-effortful types of food-seeking behavior. Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related processes, emerging evidence also implicates adenosine A2A receptors. Objective The present work was undertaken to test the hypothesis that accumbens A2A receptor stimulation would produce effects similar to those produced by DA depletion or antagonism. Materials and methods Three experiments assessed the effects of the adenosine A2A agonist CGS 21680 on performance of a concurrent choice task (lever pressing for preferred food vs. intake of less preferred chow) that is known to be sensitive to DA antagonists and accumbens DA depletions. Results Systemic injections of CGS 21680 reduced lever pressing but did not increase feeding. In contrast, bilateral infusions of the adenosine A2A receptor agonist CGS 21680 (6.0–24.0 ng) into the nucleus accumbens decreased lever pressing for the preferred food but substantially increased consumption of the less preferred chow. Injections of CGS 21680 into a control site dorsal to the accumbens were ineffective. Conclusions Taken together, these results are consistent with the hypothesis that local stimulation of adenosine A2A receptors in nucleus accumbens produces behavioral effects similar to those induced by accumbens DA depletions. Accumbens adenosine A2A receptors appear to be a component of the brain circuitry regulating effort-related choice behavior. PMID:18491078

The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists.

PubMed

Worden, Lila T; Shahriari, Mona; Farrar, Andrew M; Sink, Kelly S; Hockemeyer, Jörg; Müller, Christa E; Salamone, John D

2009-04-01

Brain dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired DA transmission reallocate their behavior away from food-seeking behaviors that have high response requirements, and instead select less effortful alternatives. Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related choice behavior, emerging evidence demonstrates a role for adenosine A(2A) receptors. Adenosine A(2A) receptor antagonism has been shown to reverse the effects of DA antagonism. The present experiments were conducted to determine if this effect was dependent upon the subtype of DA receptor that was antagonized to produce the changes in effort-related choice. The adenosine A(2A) receptor antagonist MSX-3 (0.5-2.0 mg/kg IP) was assessed for its ability to reverse the effects of the D1 family antagonist SCH39166 (ecopipam; 0.2 mg/kg IP) and the D2 family antagonist eticlopride (0.08 mg/kg IP), using a concurrent lever pressing/chow feeding procedure. MSX-3 produced a substantial dose-related reversal of the effects of eticlopride on lever pressing and chow intake. At the highest dose of MSX-3, there was a complete reversal of the effects of eticlopride on lever pressing. In contrast, MSX-3 produced only a minimal attenuation of the effects of SCH39166, as measured by regression and effect size analyses. The greater ability of MSX-3 to reverse the effects of D2 vs. D1 blockade may be related to the colocalization of D2 and adenosine A(2A) receptors on the same population of striatal neurons.

Physics design of the injector source for ITER neutral beam injector (invited).

PubMed

Antoni, V; Agostinetti, P; Aprile, D; Cavenago, M; Chitarin, G; Fonnesu, N; Marconato, N; Pilan, N; Sartori, E; Serianni, G; Veltri, P

2014-02-01

Two Neutral Beam Injectors (NBI) are foreseen to provide a substantial fraction of the heating power necessary to ignite thermonuclear fusion reactions in ITER. The development of the NBI system at unprecedented parameters (40 A of negative ion current accelerated up to 1 MV) requires the realization of a full scale prototype, to be tested and optimized at the Test Facility under construction in Padova (Italy). The beam source is the key component of the system and the design of the multi-grid accelerator is the goal of a multi-national collaborative effort. In particular, beam steering is a challenging aspect, being a tradeoff between requirements of the optics and real grids with finite thickness and thermo-mechanical constraints due to the cooling needs and the presence of permanent magnets. In the paper, a review of the accelerator physics and an overview of the whole R&D physics program aimed to the development of the injector source are presented.

Development program on a cold cathode electron gun

NASA Technical Reports Server (NTRS)

Spindt, C. A.

1979-01-01

A prototype electron gun with a field emitter cathode capable of producing 95 mA in a 1/4 mm diameter beam at 12 kV was produced. Achievement of this goal required supporting studies in cathode fabrication, cathode performance, gun design, cathode mounting and gun fabrication. A series of empirical investigations advanced fabrication technology: More stable emitters were produced and multiple cone failure caused by chain reaction discharges were reduced. The cathode is capable of producing well over 95 mA, but a substantial collector development effort was required to demonstrate emission levels in the 100 mA region. Space charge problems made these levels difficult to achieve. Recommendations are made for future process and materials investigation. Electron gun designs were modeled and tested. A pair of two-electrode gun structures were fabricated and tested; one gun was delivered to NASA. Cathodes were pretested up to 100 mA at SRI and delivered to NASA for test in the gun structure.

Neuro-vestibular and Sensory-motor Challenges Associated with NASA Mission Architectures for Moon and Mars

NASA Technical Reports Server (NTRS)

Paloski, William H.

2004-01-01

Data from six-month low Earth orbit space flight missions suggest that that substantial neuro-vestibular/sensory-motor adaptation will take place during six-month transit missions to and from Mars. Could intermittent or continuous artificial gravity be used to offset these effects? To what degree would the effects of adaptation to this rotational cure affect its potential benefits? Also, little information exists regarding the gravity thresholds for maintaining functional performance of complex sensory-motor tasks such as balance control and locomotion. Will sensory-motor coordination systems adapt to 30- 90 days of 1/6 g on the lunar surface or 18 months of 3/8 g on the Martian surface? Would some form of gravity replacement therapy be required on the surface? And, will transitions between 0 g and 1/6 g or 1/3 g present as great a challenge to the vestibular system as transitions between 0 g and 1 g? Concerted research and development efforts will be required to obtain the answers.

Characteristics of 32 supercentenarians.

PubMed

Schoenhofen, Emily A; Wyszynski, Diego F; Andersen, Stacy; Pennington, Jaemi; Young, Robert; Terry, Dellara F; Perls, Thomas T

2006-08-01

To report phenotypic characteristics of 32 age-validated supercentenarians. Case series. U.S.-based recruitment effort. Thirty-two supercentenarians. Multiple forms of proof were used to validate age claims. Sociodemographic, activities of daily living, and medical history data were collected. Age range was 110 to 119. Fifty-nine percent had Barthel Index scores in the partially to totally dependent range, whereas 41% required minimal assistance or were independent. Few subjects had a history of clinically evident vascular-related diseases, including myocardial infarction (n=2, 6%) and stroke (n=4, 13%). Twenty-two percent (n=7) were taking medications for hypertension. Twenty-five percent (n=8) had a history of cancer (all cured). Diabetes mellitus (n=1, 3%) and Parkinson's disease (n=1, 3%) were rare. Osteoporosis (n=14, 44%) and cataract history (n=28, 88%) were common. Data collected thus far suggest that supercentenarians markedly delay and even escape clinical expression of vascular disease toward the end of their exceptionally long lives. A surprisingly substantial proportion of these individuals were still functionally independent or required minimal assistance.

Energy efficient engine high-pressure turbine single crystal vane and blade fabrication technology report

NASA Technical Reports Server (NTRS)

Giamei, A. F.; Salkeld, R. W.; Hayes, C. W.

1981-01-01

The objective of the High-Pressure Turbine Fabrication Program was to demonstrate the application and feasibility of Pratt & Whitney Aircraft-developed two-piece, single crystal casting and bonding technology on the turbine blade and vane configurations required for the high-pressure turbine in the Energy Efficient Engine. During the first phase of the program, casting feasibility was demonstrated. Several blade and vane halves were made for the bonding trials, plus solid blades and vanes were successfully cast for materials evaluation tests. Specimens exhibited the required microstructure and chemical composition. Bonding feasibility was demonstrated in the second phase of the effort. Bonding yields of 75 percent for the vane and 30 percent for the blade were achieved, and methods for improving these yield percentages were identified. A bond process was established for PWA 1480 single crystal material which incorporated a transient liquid phase interlayer. Bond properties were substantiated and sensitivities determined. Tooling die materials were identified, and an advanced differential thermal expansion tooling concept was incorporated into the bond process.

Neuro-vestibular and Sensory-motor Challenges Associated with NASA Mission Architectures for Moon and Mars

NASA Technical Reports Server (NTRS)

Paloski, William H.

2004-01-01

Data from six-month low Earth orbit space flight missions suggest that that substantial neuro-vestibuladsensory-motor adaptation will take place during six-month transit missions to and from Mars. Could intermittent or continuous artificial gravity be used to offset these effects? To what degree would the effects of adaptation to this rotational cure affect its potential benefits? Also, little information exists regarding the gravity thresholds for maintaining functional performance of complex sensory-motor tasks such as balance control and locomotion. Will sensory-motor coordination systems adapt to 30-90 days of 1/6 g on the lunar surface or 18 months of 3/8 g on the Martian surface? Would some form of gravity replacement therapy be required on the surface? And, will transitions between 0 g and 1/6 g or 1/3 g present as great a challenge to the vestibular system as transitions between 0 g and 1 g? Concerted research and development efforts will be required to obtain the answers.

Modern banking, collection, compatibility testing and storage of blood and blood components.

PubMed

Green, L; Allard, S; Cardigan, R

2015-01-01

The clinical practice of blood transfusion has changed considerably over the last few decades. The potential risk of transfusion transmissible diseases has directed efforts towards the production of safe and high quality blood. All transfusion services now operate in an environment of ever-increasing regulatory controls encompassing all aspects of blood collection, processing and storage. Stringent donor selection, identification of pathogens that can be transmitted through blood, and development of technologies that can enhance the quality of blood, have all led to a substantial reduction in potential risks and complications associated with blood transfusion. In this article, we will discuss the current standards required for the manufacture of blood, starting from blood collection, through processing and on to storage. © 2014 The Association of Anaesthetists of Great Britain and Ireland.

Individual versus family psychotherapy in managed care: comparing the costs of treatment by the mental health professions.

PubMed

Russell Crane, D; Payne, Scott H

2011-07-01

In an effort to understand how psychotherapy is practiced in the "real world," outpatient claims data were examined to determine the cost of individual and family therapy provided by marital and family therapists, master's nurses, master's social workers, medical doctors, psychologists, or professional counselors. Claims for 490,000 unique persons over 4 years were obtained from CIGNA. Family therapy proved to be substantially more cost-effective than individual or "mixed" psychotherapy. Physicians provided care in the fewest sessions, marital and family therapists had the highest success (86.6%) and lowest recidivism rates (13.4%), and professional counselors were the least costly. Outcomes were overwhelmingly successful, with 85% of patients requiring only one episode of care. © 2011 American Association for Marriage and Family Therapy.

Corporate integrity agreements: making the best of a tough situation.

PubMed

Ramsey, Robert B

2002-03-01

Healthcare providers increasingly are entering into corporate integrity agreements as part of settlements with the Federal government in fraud-and-abuse cases. Providers pursue these settlements to avoid the costs of defending themselves against fraud charges. However, the costs relating to the long-term compliance activity mandated in the settlement's corporate integrity agreement also can be substantial. These costs include significant staff resources that must be devoted to compliance efforts demanded by the agreement and the required engagement of consultants to monitor the organization's compliance. Healthcare financial managers should be familiar with the elements of a typical corporate integrity agreement and understand strategies for negotiating such an agreement. Effective negotiations can help minimize the organization's costs of compliance with the agreement and facilitate its ongoing implementation of the agreement.

Reverse Launch Abort System Parachute Architecture Trade Study

NASA Technical Reports Server (NTRS)

Litton, Daniel K.; O'Keefe, Stephen A.; Winski, Richard G.

2011-01-01

This study investigated a potential Launch Abort System (LAS) Concept of Operations and abort parachute architecture. The purpose of the study was to look at the concept of jettisoning the LAS tower forward (Reverse LAS or RLAS) into the free-stream flow rather than after reorienting to a heatshield forward orientation. A hypothesized benefit was that due to the compressed timeline the dynamic pressure at main line stretch would be substantially less. This would enable the entry parachutes to be designed and sized based on entry loading conditions rather than the current stressing case of a Pad Abort. Ultimately, concerns about the highly dynamic reorientation of the CM via parachutes, and the additional requirement of a triple bridle attachment for the RLAS parachute system, overshadowed the potential benefits and ended this effort.

Visual Computing Environment Workshop

NASA Technical Reports Server (NTRS)

Lawrence, Charles (Compiler)

1998-01-01

The Visual Computing Environment (VCE) is a framework for intercomponent and multidisciplinary computational simulations. Many current engineering analysis codes simulate various aspects of aircraft engine operation. For example, existing computational fluid dynamics (CFD) codes can model the airflow through individual engine components such as the inlet, compressor, combustor, turbine, or nozzle. Currently, these codes are run in isolation, making intercomponent and complete system simulations very difficult to perform. In addition, management and utilization of these engineering codes for coupled component simulations is a complex, laborious task, requiring substantial experience and effort. To facilitate multicomponent aircraft engine analysis, the CFD Research Corporation (CFDRC) is developing the VCE system. This system, which is part of NASA's Numerical Propulsion Simulation System (NPSS) program, can couple various engineering disciplines, such as CFD, structural analysis, and thermal analysis.

Applying Corporate Climate Principles to Dental School Operations.

PubMed

Robinson, Michelle A; Reddy, Michael S

2016-12-01

Decades of research have shown that organizational climate has the potential to form the basis of workplace operations and impact an organization's performance. Culture is related to climate but is not the same. "Culture" is the broader term, defining how things are done in an organization, while "climate" is a component of culture that describes how people perceive their environment. Climate can be changed but requires substantial effort over time by management and the workforce. Interest has recently grown in culture and climate in dental education due to the humanistic culture accreditation standard. The aim of this study was to use corporate climate principles to examine how organizational culture and, subsequently, workplace operations can be improved through specific strategic efforts in a U.S. dental school. The school's parent institution initiated a climate survey that the dental school used with qualitative culture data to drive strategic planning and change in the school. Administration of the same survey to faculty and staff members three times over a six-year period showed significant changes to the school's climate occurred as a new strategic plan was implemented that focused on reforming areas of weakness. Concentrated efforts in key areas in the strategic plan resulted in measurable improvements in climate perception. The study discovered that culture was an area previously overlooked but explicitly linked to the success of the organization.

Evaluating the promise of recombinant transmissible vaccines

PubMed Central

Basinski, Andrew J.; Varrelman, Tanner J.; Smithson, Mark W.; May, Ryan H.; Remien, Christopher H.; Nuismer, Scott L.

2018-01-01

Transmissible vaccines have the potential to revolutionize infectious disease control by reducing the vaccination effort required to protect a population against a disease. Recent efforts to develop transmissible vaccines focus on recombinant transmissible vaccine designs (RTVs) because they pose reduced risk if intra-host evolution causes the vaccine to revert to its vector form. However, the shared antigenicity of the vaccine and vector may confer vaccine-immunity to hosts infected with the vector, thwarting the ability of the vaccine to spread through the population. We build a mathematical model to test whether a RTV can facilitate disease management in instances where reversion is likely to introduce the vector into the population or when the vector organism is already established in the host population, and the vector and vaccine share perfect cross-immunity. Our results show that a RTV can autonomously eradicate a pathogen, or protect a population from pathogen invasion, when cross-immunity between vaccine and vector is absent. If cross-immunity between vaccine and vector exists, however, our results show that a RTV can substantially reduce the vaccination effort necessary to control or eradicate a pathogen only when continuously augmented with direct manual vaccination. These results demonstrate that estimating the extent of cross-immunity between vector and vaccine is a critical step in RTV design, and that herpesvirus vectors showing facile reinfection and weak cross-immunity are promising. PMID:29279283

Hyper-X Engine Design and Ground Test Program

NASA Technical Reports Server (NTRS)

Voland, R. T.; Rock, K. E.; Huebner, L. D.; Witte, D. W.; Fischer, K. E.; McClinton, C. R.

1998-01-01

The Hyper-X Program, NASA's focused hypersonic technology program jointly run by NASA Langley and Dryden, is designed to move hypersonic, air-breathing vehicle technology from the laboratory environment to the flight environment, the last stage preceding prototype development. The Hyper-X research vehicle will provide the first ever opportunity to obtain data on an airframe integrated supersonic combustion ramjet propulsion system in flight, providing the first flight validation of wind tunnel, numerical and analytical methods used for design of these vehicles. A substantial portion of the integrated vehicle/engine flowpath development, engine systems verification and validation and flight test risk reduction efforts are experimentally based, including vehicle aeropropulsive force and moment database generation for flight control law development, and integrated vehicle/engine performance validation. The Mach 7 engine flowpath development tests have been completed, and effort is now shifting to engine controls, systems and performance verification and validation tests, as well as, additional flight test risk reduction tests. The engine wind tunnel tests required for these efforts range from tests of partial width engines in both small and large scramjet test facilities, to tests of the full flight engine on a vehicle simulator and tests of a complete flight vehicle in the Langley 8-Ft. High Temperature Tunnel. These tests will begin in the summer of 1998 and continue through 1999. The first flight test is planned for early 2000.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dr. Ricardo Maqueda; Dr. Fred M. Levinton

Nova Photonics, Inc. has a collaborative effort at the National Spherical Torus Experiment (NSTX). This collaboration, based on fast imaging of visible phenomena, has provided key insights on edge turbulence, intermittency, and edge phenomena such as edge localized modes (ELMs) and multi-faceted axisymmetric radiation from the edge (MARFE). Studies have been performed in all these areas. The edge turbulence/intermittency studies make use of the Gas Puff Imaging diagnostic developed by the Principal Investigator (Ricardo Maqueda) together with colleagues from PPPL. This effort is part of the International Tokamak Physics Activity (ITPA) edge, scrape-off layer and divertor group joint activity (DSOL-15:more » Inter-machine comparison of blob characteristics). The edge turbulence/blob study has been extended from the current location near the midplane of the device to the lower divertor region of NSTX. The goal of this effort was to study turbulence born blobs in the vicinity of the X-point region and their circuit closure on divertor sheaths or high density regions in the divertor. In the area of ELMs and MARFEs we have studied and characterized the mode structure and evolution of the ELM types observed in NSTX, as well as the study of the observed interaction between MARFEs and ELMs. This interaction could have substantial implications for future devices where radiative divertor regions are required to maintain detachment from the divertor plasma facing components.« less

The effects of work alienation on organisational commitment, work effort and work-to-family enrichment.

PubMed

Tummers, Lars G; Den Dulk, Laura

2013-09-01

The aim of this study was to analyse the effects of work alienation on organisational commitment, work effort and work-to-family enrichment. There is substantial research on the effects of work alienation on passive job performance, such as organisational commitment. However, studies analysing work alienation on active performance, such as work effort, and outside work, such as work-to-family enrichment, are scarce. Two dimensions of work alienation are considered: powerlessness and meaninglessness. Hypotheses are tested using surveys collected among a national sample of midwives in the Netherlands (respondents: 790, response rate 61%). the findings indicate that work alienation (powerlessness and meaninglessness) influence organisational commitment, work effort and--to a lesser extent--work-to-family enrichment. High work meaninglessness, in particular, has negative effects on these outcomes. When people feel that they have no influence in their work (hence, when they feel 'powerless') and especially when the feel that their work is not worthwhile (when they feel 'meaningless') this has substantial negative effects. Managers should increase the meaningfulness that people attach to their work, thereby maintaining a high-quality workforce. Possible strategies include: (1) improving person-job fit, (2) developing high-quality relationships, (3) better communicating the results people help to deliver. © 2013 John Wiley & Sons Ltd.

A Linux Workstation for High Performance Graphics

NASA Technical Reports Server (NTRS)

Geist, Robert; Westall, James

2000-01-01

The primary goal of this effort was to provide a low-cost method of obtaining high-performance 3-D graphics using an industry standard library (OpenGL) on PC class computers. Previously, users interested in doing substantial visualization or graphical manipulation were constrained to using specialized, custom hardware most often found in computers from Silicon Graphics (SGI). We provided an alternative to expensive SGI hardware by taking advantage of third-party, 3-D graphics accelerators that have now become available at very affordable prices. To make use of this hardware our goal was to provide a free, redistributable, and fully-compatible OpenGL work-alike library so that existing bodies of code could simply be recompiled. for PC class machines running a free version of Unix. This should allow substantial cost savings while greatly expanding the population of people with access to a serious graphics development and viewing environment. This should offer a means for NASA to provide a spectrum of graphics performance to its scientists, supplying high-end specialized SGI hardware for high-performance visualization while fulfilling the requirements of medium and lower performance applications with generic, off-the-shelf components and still maintaining compatibility between the two.

Health and Disease at Age 100.

PubMed

Jopp, Daniela S; Boerner, Kathrin; Rott, Christoph

2016-03-25

Centenarian studies from around the world have shown that reaching age 100 typically involves substantial health issues. The present study adds to the existing knowledge from other countries by describing health conditions in German centenarians. A total of 112 centenarians or their primary contacts provided information on acute and chronic health conditions and pain in the context of the Second Heidelberg Centenarian Study (mean age = 100.45 years, standard deviation [SD] = 0.47, 89% females). Participants showed high comorbidity, with an average of five illnesses (mean = 5.3; SD = 2.20). Health conditions with highest prevalence were sensory (vision, hearing; 94%), mobility (72%) and musculoskeletal conditions (60%). Cardiovascular conditions (57%) and urinary system ailments (55%) were also common. Pain was experienced often by 30% of the participants. Of those reporting any pain, 36% indicated pain exceeding bearable levels. German centenarians experienced a substantial number of ill nesses, dominated by sensory and mobility conditions. Cardiovascular diseases were the only potentially lethal illnesses with high prevalence. Evidence of unaddressed pain seems alarming, requiring future research. Emerging health profiles indicate that even in very advanced age, quality of life may be improved by enhanced diagnostics and optimal disease management. Mobility limitations may be addressed with preventive efforts.

Applications of superconducting bolometers in security imaging

NASA Astrophysics Data System (ADS)

Luukanen, A.; Leivo, M. M.; Rautiainen, A.; Grönholm, M.; Toivanen, H.; Grönberg, L.; Helistö, P.; Mäyrä, A.; Aikio, M.; Grossman, E. N.

2012-12-01

Millimeter-wave (MMW) imaging systems are currently undergoing deployment World-wide for airport security screening applications. Security screening through MMW imaging is facilitated by the relatively good transmission of these wavelengths through common clothing materials. Given the long wavelength of operation (frequencies between 20 GHz to ~ 100 GHz, corresponding to wavelengths between 1.5 cm and 3 mm), existing systems are suited for close-range imaging only due to substantial diffraction effects associated with practical aperture diameters. The present and arising security challenges call for systems that are capable of imaging concealed threat items at stand-off ranges beyond 5 meters at near video frame rates, requiring substantial increase in operating frequency in order to achieve useful spatial resolution. The construction of such imaging systems operating at several hundred GHz has been hindered by the lack of submm-wave low-noise amplifiers. In this paper we summarize our efforts in developing a submm-wave video camera which utilizes cryogenic antenna-coupled microbolometers as detectors. Whilst superconducting detectors impose the use of a cryogenic system, we argue that the resulting back-end complexity increase is a favorable trade-off compared to complex and expensive room temperature submm-wave LNAs both in performance and system cost.

Bet-hedging as a complex interaction among developmental instability, environmental heterogeneity, dispersal, and life-history strategy.

PubMed

Scheiner, Samuel M

2014-02-01

One potential evolutionary response to environmental heterogeneity is the production of randomly variable offspring through developmental instability, a type of bet-hedging. I used an individual-based, genetically explicit model to examine the evolution of developmental instability. The model considered both temporal and spatial heterogeneity alone and in combination, the effect of migration pattern (stepping stone vs. island), and life-history strategy. I confirmed that temporal heterogeneity alone requires a threshold amount of variation to select for a substantial amount of developmental instability. For spatial heterogeneity only, the response to selection on developmental instability depended on the life-history strategy and the form and pattern of dispersal with the greatest response for island migration when selection occurred before dispersal. Both spatial and temporal variation alone select for similar amounts of instability, but in combination resulted in substantially more instability than either alone. Local adaptation traded off against bet-hedging, but not in a simple linear fashion. I found higher-order interactions between life-history patterns, dispersal rates, dispersal patterns, and environmental heterogeneity that are not explainable by simple intuition. We need additional modeling efforts to understand these interactions and empirical tests that explicitly account for all of these factors.

45 CFR 150.207 - Procedure for determining that a State fails to substantially enforce PHS Act requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Procedure for determining that a State fails to... INSURANCE MARKETS CMS Enforcement Processes for Determining Whether States Are Failing To Substantially Enforce PHS Act Requirement § 150.207 Procedure for determining that a State fails to substantially...

45 CFR 150.207 - Procedure for determining that a State fails to substantially enforce HIPAA requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Procedure for determining that a State fails to... MARKETS CMS Enforcement Processes for Determining Whether States Are Failing To Substantially Enforce HIPAA Requirements § 150.207 Procedure for determining that a State fails to substantially enforce HIPAA...

45 CFR 150.207 - Procedure for determining that a State fails to substantially enforce PHS Act requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Procedure for determining that a State fails to... INSURANCE MARKETS CMS Enforcement Processes for Determining Whether States Are Failing To Substantially Enforce PHS Act Requirement § 150.207 Procedure for determining that a State fails to substantially...

45 CFR 150.207 - Procedure for determining that a State fails to substantially enforce HIPAA requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Procedure for determining that a State fails to... MARKETS CMS Enforcement Processes for Determining Whether States Are Failing To Substantially Enforce HIPAA Requirements § 150.207 Procedure for determining that a State fails to substantially enforce HIPAA...

45 CFR 150.207 - Procedure for determining that a State fails to substantially enforce HIPAA requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Procedure for determining that a State fails to... MARKETS CMS Enforcement Processes for Determining Whether States Are Failing To Substantially Enforce HIPAA Requirements § 150.207 Procedure for determining that a State fails to substantially enforce HIPAA...

Understanding Activist Leadership Effort in the Movement Opposing Drinking and Driving

PubMed Central

Dorius, Cassandra R.; McCarthy, John D.

2012-01-01

Why do some social movement leaders work harder than others? And, how does gender affect the patterns we uncover? Utilizing historical case study evidence of local chapters in the emerging movement opposing drinking and driving we are able to develop and test theoretical expectations about predictors of weekly effort among MADD and RID leaders. Taken together, our model explains 45 percent of the variation in leadership effort. We find bureaucratic complexity and victim support activities are more powerful predictors of effort than are individual leader characteristics, although all are important. Further analysis reveals that gender almost wholly conditions the strong effect of bureaucratic complexity on leadership effort so that increasingly complex chapter structures are associated with substantial increases in work hours for women but not men. PMID:22993454

Global change modeling for Northern Eurasia: a review and strategies to move forward

NASA Astrophysics Data System (ADS)

Monier, E.; Kicklighter, D. W.; Sokolov, A. P.; Zhuang, Q.; Sokolik, I. N.; Lawford, R. G.; Kappas, M.; Paltsev, S.; Groisman, P. Y.

2017-12-01

Northern Eurasia is made up of a complex and diverse set of physical, ecological, climatic and human systems, which provide important ecosystem services including the storage of substantial stocks of carbon in its terrestrial ecosystems. At the same time, the region has experienced dramatic climate change, natural disturbances and changes in land management practices over the past century. For these reasons, Northern Eurasia is both a critical region to understand and a complex system with substantial challenges for the modeling community. This review is designed to highlight the state of past and ongoing efforts of the research community to understand and model these environmental, socioeconomic, and climatic changes. We further aim to provide perspectives on the future direction of global change modeling to improve our understanding of the role of Northern Eurasia in the coupled human-Earth system. Modeling efforts have shown that environmental and socioeconomic changes in Northern Eurasia can have major impacts on biodiversity, ecosystems services, environmental sustainability, and the carbon cycle of the region, and beyond. These impacts have the potential to feedback onto and alter the global Earth system. We find that past and ongoing studies have largely focused on specific components of Earth system dynamics and have not systematically examined their feedbacks to the global Earth system and to society. We identify the crucial role of Earth system models in advancing our understanding of feedbacks within the region and with the global system. We further argue for the need for integrated assessment models (IAMs), a suite of models that couple human activity models to Earth system models, which are key to address many emerging issues that require a representation of the coupled human-Earth system.

NiftyNet: a deep-learning platform for medical imaging.

PubMed

Gibson, Eli; Li, Wenqi; Sudre, Carole; Fidon, Lucas; Shakir, Dzhoshkun I; Wang, Guotai; Eaton-Rosen, Zach; Gray, Robert; Doel, Tom; Hu, Yipeng; Whyntie, Tom; Nachev, Parashkev; Modat, Marc; Barratt, Dean C; Ourselin, Sébastien; Cardoso, M Jorge; Vercauteren, Tom

2018-05-01

Medical image analysis and computer-assisted intervention problems are increasingly being addressed with deep-learning-based solutions. Established deep-learning platforms are flexible but do not provide specific functionality for medical image analysis and adapting them for this domain of application requires substantial implementation effort. Consequently, there has been substantial duplication of effort and incompatible infrastructure developed across many research groups. This work presents the open-source NiftyNet platform for deep learning in medical imaging. The ambition of NiftyNet is to accelerate and simplify the development of these solutions, and to provide a common mechanism for disseminating research outputs for the community to use, adapt and build upon. The NiftyNet infrastructure provides a modular deep-learning pipeline for a range of medical imaging applications including segmentation, regression, image generation and representation learning applications. Components of the NiftyNet pipeline including data loading, data augmentation, network architectures, loss functions and evaluation metrics are tailored to, and take advantage of, the idiosyncracies of medical image analysis and computer-assisted intervention. NiftyNet is built on the TensorFlow framework and supports features such as TensorBoard visualization of 2D and 3D images and computational graphs by default. We present three illustrative medical image analysis applications built using NiftyNet infrastructure: (1) segmentation of multiple abdominal organs from computed tomography; (2) image regression to predict computed tomography attenuation maps from brain magnetic resonance images; and (3) generation of simulated ultrasound images for specified anatomical poses. The NiftyNet infrastructure enables researchers to rapidly develop and distribute deep learning solutions for segmentation, regression, image generation and representation learning applications, or extend the platform to new applications. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

A review of and perspectives on global change modeling for Northern Eurasia

NASA Astrophysics Data System (ADS)

Monier, Erwan; Kicklighter, David W.; Sokolov, Andrei P.; Zhuang, Qianlai; Sokolik, Irina N.; Lawford, Richard; Kappas, Martin; Paltsev, Sergey V.; Groisman, Pavel Ya

2017-08-01

Northern Eurasia is made up of a complex and diverse set of physical, ecological, climatic and human systems, which provide important ecosystem services including the storage of substantial stocks of carbon in its terrestrial ecosystems. At the same time, the region has experienced dramatic climate change, natural disturbances and changes in land management practices over the past century. For these reasons, Northern Eurasia is both a critical region to understand and a complex system with substantial challenges for the modeling community. This review is designed to highlight the state of past and ongoing efforts of the research community to understand and model these environmental, socioeconomic, and climatic changes. We further aim to provide perspectives on the future direction of global change modeling to improve our understanding of the role of Northern Eurasia in the coupled human-Earth system. Modeling efforts have shown that environmental and socioeconomic changes in Northern Eurasia can have major impacts on biodiversity, ecosystems services, environmental sustainability, and the carbon cycle of the region, and beyond. These impacts have the potential to feedback onto and alter the global Earth system. We find that past and ongoing studies have largely focused on specific components of Earth system dynamics and have not systematically examined their feedbacks to the global Earth system and to society. We identify the crucial role of Earth system models in advancing our understanding of feedbacks within the region and with the global system. We further argue for the need for integrated assessment models (IAMs), a suite of models that couple human activity models to Earth system models, which are key to address many emerging issues that require a representation of the coupled human-Earth system.

A systems approach to improving rural care in Ethiopia.

PubMed

Bradley, Elizabeth H; Byam, Patrick; Alpern, Rachelle; Thompson, Jennifer W; Zerihun, Abraham; Abebe, Yigeremu; Abeb, Yigeremu; Curry, Leslie A

2012-01-01

Multiple interventions have been launched to improve the quality, access, and utilization of primary health care in rural, low-income settings; however, the success of these interventions varies substantially, even within single studies where the measured impact of interventions differs across sites, centers, and regions. Accordingly, we sought to examine the variation in impact of a health systems strengthening intervention and understand factors that might explain the variation in impact across primary health care units. We conducted a mixed methods positive deviance study of 20 Primary Health Care Units (PHCUs) in rural Ethiopia. Using longitudinal data from the Ethiopia Millennium Rural Initiative (EMRI), we identified PHCUs with consistently higher performance (n = 2), most improved performance (n = 3), or consistently lower performance (n = 2) in the provision of antenatal care, HIV testing in antenatal care, and skilled birth attendance rates. Using data from site visits and in-depth interviews (n = 51), we applied the constant comparative method of qualitative data analysis to identify key themes that distinguished PHCUs with different performance trajectories. Key themes that distinguished PHCUs were 1) managerial problem solving capacity, 2) relationship with the woreda (district) health office, and 3) community engagement. In higher performing PHCUs and those with the greatest improvement after the EMRI intervention, health center and health post staff were more able to solve day-to-day problems, staff had better relationships with the woreda health official, and PHCU communities' leadership, particularly religious leadership, were strongly engaged with the health improvement effort. Distance from the nearest city, quality of roads and transportation, and cultural norms did not differ substantially among PHCUs. Effective health strengthening efforts may require intensive development of managerial problem solving skills, strong relationships with government offices that oversee front-line providers, and committed community leadership to succeed.

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

40 CFR 350.27 - Substantiation form to accompany claims of trade secrecy, instructions to substantiation form.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TRADE SECRET DISCLOSURES TO HEALTH PROFESSIONALS Trade Secrecy Claims § 350.27 Substantiation form to... Secret Substantiation Form General Information EPA requires that the information requested in a trade secret substantiation be completed using this substantiation form in order to ensure that all facility...

Urinary tract infections cranberry juice, underwear, and probiotics in the 21st century.

PubMed

Miller, Jane L; Krieger, John N

2002-08-01

There is a substantial gap between the viewpoint of urologists and the rest of society regarding UTIs. Urologists spend little time and effort thinking about UTIs. In contrast, UTIs are a major issue for many women. There is substantial concern about "natural compounds" and probiotics that allow women to take charge of their health care. It is easy to understand this concern because UTIs are common, costly, and cause considerable morbidity.

Determinants of implementation of maternal health guidelines in Kosovo: mixed methods study

PubMed Central

2013-01-01

Background One of the challenges to implementing clinical practice guidelines is the need to adapt guidelines to the local context and identify barriers to their uptake. Several models of framework are available to consider for use in guideline adaptation. Methods We completed a multiphase study to explore the implementation of maternal health guidelines in Kosovo, focusing on determinants of uptake and methods to contextualize for local use. The study involved a survey, individual interviews, focus groups, and a consensus meeting with relevant stakeholders, including clinicians (obstetricians, midwives), managers, researchers, and policy makers from the national Ministry of Health and the World Health Organization office in Pristina, Kosovo. Results Participants identified several important barriers to implementation. First, lack of communication between clinicians and ministry representatives was seen as leading to duplication of effort in creating or adapting guidelines, as well as substantial mistrust between clinicians and policy makers. Second, there was a lack of communication across clinical groups that provide obstetric care and a lack of integration across the entire healthcare system, including rural and urban centers. This fragmentation was thought to have directly resulted from the war in 1998 – 1999. Third, the conflict substantially and adversely affected the healthcare infrastructure in Kosovo, which has resulted in an inability to monitor quality of care across the country. Furthermore, the impact on infrastructure has affected the ability to access required medications consistently and to smoothly transfer patients from rural to urban centers. Another issue raised during this project was the appropriateness of including guideline recommendations perceived to be ‘aspirational’. Conclusions Implementing clinical practice guidelines in low- and middle-income countries (LMICs) requires consideration of several specific barriers. Particularly pertinent to this study were the effects of recent conflict and the resulting fragmentation of healthcare and communication strategies among relevant stakeholders. However, as Kosovo rebuilds and invests in infrastructure after the conflict, there is a tremendous opportunity to create comprehensive, thoughtful strategies to monitor and improve quality of care. To avoid duplication of effort, it may be beneficial for LMICs to share information on assessing barriers as well as on guideline implementation strategies. PMID:24016149

Establishing a Framework for Community Modeling in Hydrologic Science: Recommendations from the CUAHSI CHyMP Initiative

NASA Astrophysics Data System (ADS)

Arrigo, J. S.; Famiglietti, J. S.; Murdoch, L. C.; Lakshmi, V.; Hooper, R. P.

2012-12-01

The Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) continues a major effort towards supporting Community Hydrologic Modeling. From 2009 - 2011, the Community Hydrologic Modeling Platform (CHyMP) initiative held three workshops, the ultimate goal of which was to produce recommendations and an implementation plan to establish a community modeling program that enables comprehensive simulation of water anywhere on the North American continent. Such an effort would include connections to and advances in global climate models, biogeochemistry, and efforts of other disciplines that require an understanding of water patterns and processes in the environment. To achieve such a vision will require substantial investment in human and cyber-infrastructure and significant advances in the science of hydrologic modeling and spatial scaling. CHyMP concluded with a final workshop, held March 2011, and produced several recommendations. CUAHSI and the university community continue to advance community modeling and implement these recommendations through several related and follow on efforts. Key results from the final 2011 workshop included agreement among participants that the community is ready to move forward with implementation. It is recognized that initial implementation of this larger effort can begin with simulation capabilities that currently exist, or that can be easily developed. CHyMP identified four key activities in support of community modeling: benchmarking, dataset evaluation and development, platform evaluation, and developing a national water model framework. Key findings included: 1) The community supported the idea of a National Water Model framework; a community effort is needed to explore what the ultimate implementation of a National Water Model is. A true community modeling effort would support the modeling of "water anywhere" and would include all relevant scales and processes. 2) Implementation of a community modeling program could initially focus on continental scale modeling of water quantity (rather than quality). The goal of this initial model is the comprehensive description of water stores and fluxes in such a way to permit linkage to GCM's, biogeochemical, ecological, and geomorphic models. This continental scale focus allows systematic evaluation of our current state of knowledge and data, leverages existing efforts done by large scale modelers, contributes to scientific discovery that informs globally and societal relevant questions, and provides an initial framework to evaluate hydrologic information relevant to other disciplines and a structure into which to incorporate other classes of hydrologic models. 3) Dataset development will be a key aspect of any successful national water model implementation. Our current knowledge of the subsurface is limiting our ability to truly integrate soil and groundwater into large scale models, and to answering critical science questions with societal relevance (i.e. groundwater's influence on climate). 4) The CHyMP workshops and efforts to date have achieved collaboration between university scientists, government agencies and the private sector that must be maintained. Follow on efforts in community modeling should aim at leveraging and maintaining this collaboration for maximum scientific and societal benefit.

Flexible Fabrics with High Thermal Conductivity for Advanced Spacesuits

NASA Technical Reports Server (NTRS)

Trevino, Luis A.; Bue, Grant; Orndoff, Evelyne; Kesterson, Matt; Connel, John W.; Smith, Joseph G., Jr.; Southward, Robin E.; Working, Dennis; Watson, Kent A.; Delozier, Donovan M.

2006-01-01

This paper describes the effort and accomplishments for developing flexible fabrics with high thermal conductivity (FFHTC) for spacesuits to improve thermal performance, lower weight and reduce complexity. Commercial and additional space exploration applications that require substantial performance enhancements in removal and transport of heat away from equipment as well as from the human body can benefit from this technology. Improvements in thermal conductivity were achieved through the use of modified polymers containing thermally conductive additives. The objective of the FFHTC effort is to significantly improve the thermal conductivity of the liquid cooled ventilation garment by improving the thermal conductivity of the subcomponents (i.e., fabric and plastic tubes). This paper presents the initial system modeling studies, including a detailed liquid cooling garment model incorporated into the Wissler human thermal regulatory model, to quantify the necessary improvements in thermal conductivity and garment geometries needed to affect system performance. In addition, preliminary results of thermal conductivity improvements of the polymer components of the liquid cooled ventilation garment are presented. By improving thermal garment performance, major technology drivers will be addressed for lightweight, high thermal conductivity, flexible materials for spacesuits that are strategic technical challenges of the Exploration

Source apportionment of indoor air pollution

NASA Astrophysics Data System (ADS)

Sexton, Ken; Hayward, Steven B.

An understanding of the relative contributions from important pollutant sources to human exposures is necessary for the design and implementation of effective control strategies. In the past, societal efforts to control air pollution have focused almost exclusively on the outdoor (ambient) environment. As a result, substantial amounts of time and money have been spent to limit airborne discharges from mobile and stationary sources. Yet it is now recognized that exposures to elevated pollutant concentrations often occur as a result of indoor, rather than outdoor, emissions. While the major indoor sources have been identified, their relative impacts on indoor air quality have not been well defined. Application of existing source apportionment models to nonindustrial indoor environments is only just beginning. It is possible that these models might be used to distinguish between indoor and outdoor emissions, as well as to distinguish among indoor sources themselves. However, before the feasibility and suitability of source-apportionment methods for indoor applications can be assessed adequately, it is necessary to take account of model assumptions and associated data requirements. This paper examines the issue of indoor source apportionment and reviews the need for emission characterization studies to support such source-apportionment efforts.

Software Reliability 2002

NASA Technical Reports Server (NTRS)

Wallace, Dolores R.

2003-01-01

In FY01 we learned that hardware reliability models need substantial changes to account for differences in software, thus making software reliability measurements more effective, accurate, and easier to apply. These reliability models are generally based on familiar distributions or parametric methods. An obvious question is 'What new statistical and probability models can be developed using non-parametric and distribution-free methods instead of the traditional parametric method?" Two approaches to software reliability engineering appear somewhat promising. The first study, begin in FY01, is based in hardware reliability, a very well established science that has many aspects that can be applied to software. This research effort has investigated mathematical aspects of hardware reliability and has identified those applicable to software. Currently the research effort is applying and testing these approaches to software reliability measurement, These parametric models require much project data that may be difficult to apply and interpret. Projects at GSFC are often complex in both technology and schedules. Assessing and estimating reliability of the final system is extremely difficult when various subsystems are tested and completed long before others. Parametric and distribution free techniques may offer a new and accurate way of modeling failure time and other project data to provide earlier and more accurate estimates of system reliability.

Adoption of Electronic Health Records: A Roadmap for India

PubMed Central

2016-01-01

Objectives The objective of the study was to create a roadmap for the adoption of Electronic Health Record (EHR) in India based an analysis of the strategies of other countries and national scenarios of ICT use in India. Methods The strategies for adoption of EHR in other countries were analyzed to find the crucial steps taken. Apart from reports collected from stakeholders in the country, the study relied on the experience of the author in handling several e-health projects. Results It was found that there are four major areas where the countries considered have made substantial efforts: ICT infrastructure, Policy & regulations, Standards & interoperability, and Research, development & education. A set of crucial activities were identified in each area. Based on the analysis, a roadmap is suggested. It includes the creation of a secure health network; health information exchange; and the use of open-source software, a national health policy, privacy laws, an agency for health IT standards, R&D, human resource development, etc. Conclusions Although some steps have been initiated, several new steps need to be taken up for the successful adoption of EHR. It requires a coordinated effort from all the stakeholders. PMID:27895957

Potential adjustment methodology for missing data and reporting delay in the HIV Surveillance System, European Union/European Economic Area, 2015.

PubMed

Rosinska, Magdalena; Pantazis, Nikos; Janiec, Janusz; Pharris, Anastasia; Amato-Gauci, Andrew J; Quinten, Chantal; Ecdc Hiv/Aids Surveillance Network

2018-06-01

Accurate case-based surveillance data remain the key data source for estimating HIV burden and monitoring prevention efforts in Europe. We carried out a literature review and exploratory analysis of surveillance data regarding two crucial issues affecting European surveillance for HIV: missing data and reporting delay. Initial screening showed substantial variability of these data issues, both in time and across countries. In terms of missing data, the CD4+ cell count is the most problematic variable because of the high proportion of missing values. In 20 of 31 countries of the European Union/European Economic Area (EU/EEA), CD4+ counts are systematically missing for all or some years. One of the key challenges related to reporting delays is that countries undertake specific one-off actions in effort to capture previously unreported cases, and that these cases are subsequently reported with excessive delays. Slightly different underlying assumptions and effectively different models may be required for individual countries to adjust for missing data and reporting delays. However, using a similar methodology is recommended to foster harmonisation and to improve the accuracy and usability of HIV surveillance data at national and EU/EEA levels.

Environmental Gap Analysis to Prioritize Conservation Efforts in Eastern Africa

PubMed Central

van Breugel, Paulo; Kindt, Roeland; Lillesø, Jens-Peter Barnekow; van Breugel, Michiel

2015-01-01

Countries in eastern Africa have set aside significant proportions of their land for protection. But are these areas representative of the diverse range of species and habitats found in the region? And do conservation efforts include areas where the state of biodiversity is likely to deteriorate without further interventions? Various studies have addressed these questions at global and continental scales. However, meaningful conservation decisions are required at finer geographical scales. To operate more effectively at the national level, finer scale baseline data on species and on higher levels of biological organization such as the eco-regions are required, among other factors. Here we adopted a recently developed high-resolution potential natural vegetation (PNV) map for eastern Africa as a baseline to more effectively identify conservation priorities. We examined how well different potential natural vegetations (PNVs) are represented in the protected area (PA) network of eastern Africa and used a multivariate environmental similarity index to evaluate biases in PA versus PNV coverage. We additionally overlaid data of anthropogenic factors that potentially influence the natural vegetation to assess the level of threat to different PNVs. Our results indicate substantial differences in the conservation status of PNVs. In addition, particular PNVs in which biodiversity protection and ecological functions are at risk due to human influences are revealed. The data and approach presented here provide a step forward in developing more transparent and better informed translation from global priorities to regional or national implementation in eastern Africa, and are valid for other geographic regions. PMID:25855968

Application of ISO standard 27048: dose assessment for the monitoring of workers for internal radiation exposure.

PubMed

Henrichs, K

2011-03-01

Besides ongoing developments in the dosimetry of incorporated radionuclides, there are various efforts to improve the monitoring of workers for potential or real intakes of radionuclides. The disillusioning experience with numerous intercomparison projects identified substantial differences between national regulations, concepts, applied programmes and methods, and dose assessment procedures. Measured activities were not directly comparable because of significant differences between measuring frequencies and methods, but also results of case studies for dose assessments revealed differences of orders of magnitude. Besides the general common interest in reliable monitoring results, at least the cross-border activities of workers (e.g. nuclear power plant services) require consistent approaches and comparable results. The International Standardization Organization therefore initiated projects to standardise programmes for the monitoring of workers, the requirements for measuring laboratories and the processes for the quantitative evaluation of monitoring results in terms of internal assessed doses. The strength of the concepts applied by the international working group consists in a unified approach defining the requirements, databases and processes. This paper is intended to give a short introduction into the standardization project followed by a more detailed description of the dose assessment standard, which will be published in the very near future.

Numerical solution of the incompressible Navier-Stokes equations. Ph.D. Thesis - Stanford Univ., Mar. 1989

NASA Technical Reports Server (NTRS)

Rogers, Stuart E.

1990-01-01

The current work is initiated in an effort to obtain an efficient, accurate, and robust algorithm for the numerical solution of the incompressible Navier-Stokes equations in two- and three-dimensional generalized curvilinear coordinates for both steady-state and time-dependent flow problems. This is accomplished with the use of the method of artificial compressibility and a high-order flux-difference splitting technique for the differencing of the convective terms. Time accuracy is obtained in the numerical solutions by subiterating the equations in psuedo-time for each physical time step. The system of equations is solved with a line-relaxation scheme which allows the use of very large pseudo-time steps leading to fast convergence for steady-state problems as well as for the subiterations of time-dependent problems. Numerous laminar test flow problems are computed and presented with a comparison against analytically known solutions or experimental results. These include the flow in a driven cavity, the flow over a backward-facing step, the steady and unsteady flow over a circular cylinder, flow over an oscillating plate, flow through a one-dimensional inviscid channel with oscillating back pressure, the steady-state flow through a square duct with a 90 degree bend, and the flow through an artificial heart configuration with moving boundaries. An adequate comparison with the analytical or experimental results is obtained in all cases. Numerical comparisons of the upwind differencing with central differencing plus artificial dissipation indicates that the upwind differencing provides a much more robust algorithm, which requires significantly less computing time. The time-dependent problems require on the order of 10 to 20 subiterations, indicating that the elliptical nature of the problem does require a substantial amount of computing effort.

Ocean OSSEs: recent developments and future challenges

NASA Astrophysics Data System (ADS)

Kourafalou, V. H.

2012-12-01

Atmospheric OSSEs have had a much longer history of applications than OSSEs (and OSEs) in oceanography. Long standing challenges include the presence of coastlines and steep bathymetric changes, which require the superposition of a wide variety of space and time scales, leading to difficulties on ocean observation and prediction. For instance, remote sensing is critical for providing a quasi-synoptic oceanographic view, but the coverage is limited at the ocean surface. Conversely, in situ measurements are capable to monitor the entire water column, but at a single location and usually for a specific, short time. Despite these challenges, substantial progress has been made in recent years and international initiatives have provided successful OSSE/OSE examples and formed appropriate forums that helped define the future roadmap. These will be discussed, together with various challenges that require a community effort. Examples include: integrated (remote and in situ) observing system requirements for monitoring large scale and climatic changes, vs. short term variability that is particularly important on the regional and coastal spatial scales; satisfying the needs of both global and regional/coastal nature runs, from development to rigorous evaluation and under a clear definition of metrics; data assimilation in the presence of tides; estimation of real-time river discharges for Earth system modeling. An overview of oceanographic efforts that complement the standard OSSE methodology will also be given. These include ocean array design methods, such as representer-based analysis and adaptive sampling. Exciting new opportunities for both global and regional ocean OSSE/OSE studies have recently become possible with targeted periods of comprehensive data sets, such as the existing Gulf of Mexico observations from multiple sources in the aftermath of the DeepWater Horizon incident and the upcoming airborne AirSWOT, in preparation for the SWOT (Surface Water and Ocean Topography) mission.

APNEA/WIT system nondestructive assay capability evaluation plan for select accessibly stored INEL RWMC waste forms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Becker, G.K.

1997-01-01

Bio-Imaging Research Inc. (BIR) and Lockheed Martin Speciality Components (LMSC) are engaged in a Program Research and Development Agreement and a Rapid Commercialization Initiative with the Department of Energy, EM-50. The agreement required BIR and LMSC to develop a data interpretation method that merges nondestructive assay and nondestructive examination (NDA/NDE) data and information sufficient to establish compliance with applicable National TRU Program (Program) waste characterization requirements and associated quality assurance performance criteria. This effort required an objective demonstration of the BIR and LMSC waste characterization systems in their standalone and integrated configurations. The goal of the test plan is tomore » provide a mechanism from which evidence can be derived to substantiate nondestructive assay capability and utility statement for the BIT and LMSC systems. The plan must provide for the acquisition, compilation, and reporting of performance data thereby allowing external independent agencies a basis for an objective evaluation of the standalone BIR and LMSC measurement systems, WIT and APNEA respectively, as well as an expected performance resulting from appropriate integration of the two systems. The evaluation is to be structured such that a statement regarding select INEL RWMC waste forms can be made in terms of compliance with applicable Program requirements and criteria.« less

Aerobic conditioning for team sport athletes.

PubMed

Stone, Nicholas M; Kilding, Andrew E

2009-01-01

Team sport athletes require a high level of aerobic fitness in order to generate and maintain power output during repeated high-intensity efforts and to recover. Research to date suggests that these components can be increased by regularly performing aerobic conditioning. Traditional aerobic conditioning, with minimal changes of direction and no skill component, has been demonstrated to effectively increase aerobic function within a 4- to 10-week period in team sport players. More importantly, traditional aerobic conditioning methods have been shown to increase team sport performance substantially. Many team sports require the upkeep of both aerobic fitness and sport-specific skills during a lengthy competitive season. Classic team sport trainings have been shown to evoke marginal increases/decreases in aerobic fitness. In recent years, aerobic conditioning methods have been designed to allow adequate intensities to be achieved to induce improvements in aerobic fitness whilst incorporating movement-specific and skill-specific tasks, e.g. small-sided games and dribbling circuits. Such 'sport-specific' conditioning methods have been demonstrated to promote increases in aerobic fitness, though careful consideration of player skill levels, current fitness, player numbers, field dimensions, game rules and availability of player encouragement is required. Whilst different conditioning methods appear equivalent in their ability to improve fitness, whether sport-specific conditioning is superior to other methods at improving actual game performance statistics requires further research.

Controlling for varying effort in count surveys --an analysis of Christmas Bird Count Data

USGS Publications Warehouse

Link, W.A.; Sauer, J.R.

1999-01-01

The Christmas Bird Count (CBC) is a valuable source of information about midwinter populations of birds in the continental U.S. and Canada. Analysis of CBC data is complicated by substantial variation among sites and years in effort expended in counting; this feature of the CBC is common to many other wildlife surveys. Specification of a method for adjusting counts for effort is a matter of some controversy. Here, we present models for longitudinal count surveys with varying effort; these describe the effect of effort as proportional to exp(B effortp), where B and p are parameters. For any fixed p, our models are loglinear in the transformed explanatory variable (effort)p and other covariables. Hence we fit a collection of loglinear models corresponding to a range of values of p, and select the best effort adjustment from among these on the basis of fit statistics. We apply this procedure to data for six bird species in five regions, for the period 1959-1988.

Passive smoking: directions for health education among Malaysian college students.

PubMed

Kurtz, M E; Johnson, S M; Ross-Lee, B

1992-01-01

This study investigated knowledge, attitudes, and preventive efforts of Malaysian college students regarding health risks associated with passive smoking, as well as possible directions for intervention and health education programs. Students responded anonymously to a structured written questionnaire. Statistical analyses were conducted to examine (1) differences in knowledge, attitudes, and preventive efforts between smokers and nonsmokers and between men and women; (2) the relationship between smoking by parents, siblings, and friends, and students' knowledge, attitudes, and preventive efforts; and (3) relationships between knowledge, attitudes, and preventive efforts. Peer groups and siblings had a substantial influence on students' attitudes toward passive smoking and their preventive efforts when exposed to passive smoke. A regression analysis revealed a statistically significant linear dependence of preventive efforts on knowledge and attitudes, with the attitude component playing the dominant role. This research suggests that educational efforts on passive smoking, directed toward young college students in developing countries such as Malaysia, should concentrate heavily on changing attitudes and reducing the effects of peer group and sibling influences.

Intersection management using in-vehicle speed advisory/adaptation : final report.

DOT National Transportation Integrated Search

2016-08-30

In recent years, connected vehicles (CVs) and automated vehicles (AVs) have emerged as a : realistic and viable transportation option. Research centers and companies have dedicated : substantial efforts to the technology, motivated largely by the pot...

42 CFR 418.66 - Condition of participation: Nursing services-Waiver of requirement that substantially all nursing...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Condition of participation: Nursing services-Waiver of requirement that substantially all nursing services be routinely provided directly by a hospice...: Patient Care Core Services § 418.66 Condition of participation: Nursing services—Waiver of requirement...

42 CFR 418.66 - Condition of participation: Nursing services-Waiver of requirement that substantially all nursing...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Condition of participation: Nursing services-Waiver of requirement that substantially all nursing services be routinely provided directly by a hospice...: Patient Care Core Services § 418.66 Condition of participation: Nursing services—Waiver of requirement...

42 CFR 418.66 - Condition of participation: Nursing services-Waiver of requirement that substantially all nursing...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Condition of participation: Nursing services-Waiver of requirement that substantially all nursing services be routinely provided directly by a hospice...: Patient Care Core Services § 418.66 Condition of participation: Nursing services—Waiver of requirement...

Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory, and Astrophysical Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Michael R.

2006-11-16

Project Title: Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory, and Astrophysical Applications PI: Michael R. Brown, Swarthmore College The purpose of the project was to provide theoretical and modeling support to the Swarthmore Spheromak Experiment (SSX). Accordingly, the theoretical effort was tightly integrated into the SSX experimental effort. During the grant period, Michael Brown and his experimental collaborators at Swarthmore, with assistance from W. Matthaeus as appropriate, made substantial progress in understanding the physics SSX plasmas.

Civil Rights, Social Justice, and Black America. A Review of Past and Current Ford Foundation Efforts to Promote Racial Justice for Black Americans in Employment, Education, Housing, Political Participation, and Other Areas. Working Paper.

ERIC Educational Resources Information Center

Walker, Lynn

For more than 15 years, the Ford Foundation has supported a substantial program to expand opportunity for black Americans, and more recently, for America's other racial minorities and for women. This working paper summarizes the Foundation's past efforts and describes new initiatives being taken on behalf of these minorities, particularly blacks.…

Biological design in science classrooms

PubMed Central

Scott, Eugenie C.; Matzke, Nicholas J.

2007-01-01

Although evolutionary biology is replete with explanations for complex biological structures, scientists concerned about evolution education have been forced to confront “intelligent design” (ID), which rejects a natural origin for biological complexity. The content of ID is a subset of the claims made by the older “creation science” movement. Both creationist views contend that highly complex biological adaptations and even organisms categorically cannot result from natural causes but require a supernatural creative agent. Historically, ID arose from efforts to produce a form of creationism that would be less vulnerable to legal challenges and that would not overtly rely upon biblical literalism. Scientists do not use ID to explain nature, but because it has support from outside the scientific community, ID is nonetheless contributing substantially to a long-standing assault on the integrity of science education. PMID:17494747

Genetic Parallel Programming: design and implementation.

PubMed

Cheang, Sin Man; Leung, Kwong Sak; Lee, Kin Hong

2006-01-01

This paper presents a novel Genetic Parallel Programming (GPP) paradigm for evolving parallel programs running on a Multi-Arithmetic-Logic-Unit (Multi-ALU) Processor (MAP). The MAP is a Multiple Instruction-streams, Multiple Data-streams (MIMD), general-purpose register machine that can be implemented on modern Very Large-Scale Integrated Circuits (VLSIs) in order to evaluate genetic programs at high speed. For human programmers, writing parallel programs is more difficult than writing sequential programs. However, experimental results show that GPP evolves parallel programs with less computational effort than that of their sequential counterparts. It creates a new approach to evolving a feasible problem solution in parallel program form and then serializes it into a sequential program if required. The effectiveness and efficiency of GPP are investigated using a suite of 14 well-studied benchmark problems. Experimental results show that GPP speeds up evolution substantially.

What matters most: quantifying an epidemiology of consequence

PubMed Central

Keyes, Katherine; Galea, Sandro

2015-01-01

Risk factor epidemiology has contributed to substantial public health success. In this essay, we argue, however, that the focus on risk factor epidemiology has led epidemiology to ever increasing focus on the estimation of precise causal effects of exposures on an outcome at the expense of engagement with the broader causal architecture that produces population health. To conduct an epidemiology of consequence, a systematic effort is needed to engage our science in a critical reflection both about how well and under what conditions or assumptions we can assess causal effects and also on what will truly matter most for changing population health. Such an approach changes the priorities and values of the discipline and requires reorientation of how we structure the questions we ask and the methods we use, as well as how we teach epidemiology to our emerging scholars. PMID:25749559

Anion permselective membrane

NASA Technical Reports Server (NTRS)

Alexander, S.; Hodgdon, R. B.

1977-01-01

The objective of NAS 3-20108 was the development and evaluation of improved anion selective membranes useful as efficient separators in a redox power storage cell system being constructed. The program was divided into three parts, (a) optimization of the selected candidate membrane systems, (b) investigation of alternative membrane/polymer systems, and (c) characterization of candidate membranes. The major synthesis effort was aimed at improving and optimizing as far as possible each candidate system with respect to three critical membrane properties essential for good redox cell performance. Substantial improvements were made in 5 candidate membrane systems. The critical synthesis variables of cross-link density, monomer ratio, and solvent composition were examined over a wide range. In addition, eight alternative polymer systems were investigated, two of which attained candidate status. Three other alternatives showed potential but required further research and development. Each candidate system was optimized for selectivity.

Collaboration essential for an energy neutral urban water cycle.

PubMed

Frijns, Jos; Mulder, Mirabella; Roorda, Jelle; Schepman, Hans; Voskamp, Tom

2013-01-01

Two Dutch water boards prepared a Master Plan with measures to substantially reduce their energy use by 2027. In total, more than 100 measures were identified such as bubble aeration and heat recovery from effluent. Together these measures result in a 90-95% reduction in energy use at the water boards. However, for the whole urban water cycle, thus including the energy required for warm water use in households, the total energy reduction from these measures at the water boards is only 5-6%. To attain the objective to have an energy neutral urban water cycle, collaboration with other sectors such as housing, energy, agriculture and industry will be essential. Active collaboration of the water boards through the incorporation of energy efficient water measures as part of the carbon neutral effort of cities is recognized to be a promising strategy.

Computer modeling of Epilepsy

PubMed Central

Lytton, William W.

2009-01-01

Preface Epilepsy is a complex set of disorders that can involve many areas of cortex as well as underlying deep brain systems. The myriad manifestations of seizures, as varied as déjà vu and olfactory hallucination, can thereby give researchers insights into regional functions and relations. Epilepsy is also complex genetically and pathophysiologically, involving microscopic (ion channels, synaptic proteins), macroscopic (brain trauma and rewiring) and intermediate changes in a complex interplay of causality. It has long been recognized that computer modeling will be required to disentangle causality, to better understand seizure spread and to understand and eventually predict treatment efficacy. Over the past few years, substantial progress has been made modeling epilepsy at levels ranging from the molecular to the socioeconomic. We review these efforts and connect them to the medical goals of understanding and treating this disorder. PMID:18594562

Gigaflop (billion floating point operations per second) performance for computational electromagnetics

NASA Technical Reports Server (NTRS)

Shankar, V.; Rowell, C.; Hall, W. F.; Mohammadian, A. H.; Schuh, M.; Taylor, K.

1992-01-01

Accurate and rapid evaluation of radar signature for alternative aircraft/store configurations would be of substantial benefit in the evolution of integrated designs that meet radar cross-section (RCS) requirements across the threat spectrum. Finite-volume time domain methods offer the possibility of modeling the whole aircraft, including penetrable regions and stores, at longer wavelengths on today's gigaflop supercomputers and at typical airborne radar wavelengths on the teraflop computers of tomorrow. A structured-grid finite-volume time domain computational fluid dynamics (CFD)-based RCS code has been developed at the Rockwell Science Center, and this code incorporates modeling techniques for general radar absorbing materials and structures. Using this work as a base, the goal of the CFD-based CEM effort is to define, implement and evaluate various code development issues suitable for rapid prototype signature prediction.

Assessing how much couples work at their relationship: the behavioral self-regulation for effective relationships scale.

PubMed

Wilson, Keithia L; Charker, Jill; Lizzio, Alf; Halford, Kim; Kimlin, Siobhan

2005-09-01

It is widely believed that satisfying couple relationships require work by the partners. The authors equated the concept of work to relationship self-regulation and developed a scale to assess this construct. A factor analysis of the scale in a sample of 187 newlywed couples showed it comprised 2 factors of relationship strategies and effort. The factor structure was replicated in an independent sample of 97 newlywed couples. In both samples the scale had good internal consistency and high convergent validity between self- and partner-report forms. Self-regulation accounted for substantial variance in relationship satisfaction in both newlywed samples and in a 3rd sample of 61 long-married couples. The self-regulation and satisfaction association was independent of mood or self-report common method variance. (c) 2005 APA, all rights reserved

Aerial survey methodology for bison population estimation in Yellowstone National Park

USGS Publications Warehouse

Hess, Steven C.

2002-01-01

I developed aerial survey methods for statistically rigorous bison population estimation in Yellowstone National Park to support sound resource management decisions and to understand bison ecology. Survey protocols, data recording procedures, a geographic framework, and seasonal stratifications were based on field observations from February 1998-September 2000. The reliability of this framework and strata were tested with long-term data from 1970-1997. I simulated different sample survey designs and compared them to high-effort censuses of well-defined large areas to evaluate effort, precision, and bias. Sample survey designs require much effort and extensive information on the current spatial distribution of bison and therefore do not offer any substantial reduction in time and effort over censuses. I conducted concurrent ground surveys, or 'double sampling' to estimate detection probability during aerial surveys. Group size distribution and habitat strongly affected detection probability. In winter, 75% of the groups and 92% of individual bison were detected on average from aircraft, while in summer, 79% of groups and 97% of individual bison were detected. I also used photography to quantify the bias due to counting large groups of bison accurately and found that undercounting increased with group size and could reach 15%. I compared survey conditions between seasons and identified optimal time windows for conducting surveys in both winter and summer. These windows account for the habitats and total area bison occupy, and group size distribution. Bison became increasingly scattered over the Yellowstone region in smaller groups and more occupied unfavorable habitats as winter progressed. Therefore, the best conditions for winter surveys occur early in the season (Dec-Jan). In summer, bison were most spatially aggregated and occurred in the largest groups by early August. Low variability between surveys and high detection probability provide population estimates with an overall coefficient of variation of approximately 8% and have high power for detecting trends in population change. I demonstrated how population estimates from winter and summer can be integrated into a comprehensive monitoring program to estimate annual growth rates, overall winter mortality, and an index of calf production, requiring about 30 hours of flight per year.

47 CFR 95.831 - Service requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... that it provides substantial service within the service area. Substantial service is defined as a service that is sound, favorable, and substantially above a level of service which might minimally warrant...

Comparative Influence of Ocean Conditions on Yellowfin and Atlantic Bluefin Tuna Catch from Longlines in the Gulf of Mexico

PubMed Central

Teo, Steven L. H.; Block, Barbara A.

2010-01-01

Directed fishing effort for Atlantic bluefin tuna in the Gulf of Mexico (GOM), their primary spawning grounds in the western Atlantic, has been prohibited since the 1980s due to a precipitous decline of the spawning stock biomass. However, pelagic longlines targeted at other species, primarily yellowfin tuna and swordfish, continue to catch Atlantic bluefin tuna in the GOM as bycatch. Spatial and temporal management measures minimizing bluefin tuna bycatch in the GOM will likely become important in rebuilding the western Atlantic bluefin stock. In order to help inform management policy and understand the relative distribution of target and bycatch species in the GOM, we compared the spatiotemporal variability and environmental influences on the catch per unit effort (CPUE) of yellowfin (target) and bluefin tuna (bycatch). Catch and effort data from pelagic longline fisheries observers (1993–2005) and scientific tagging cruises (1998–2002) were coupled with environmental and biological data. Negative binomial models were used to fit the data for both species and Akaike's Information Criterion (corrected for small sample size) was used to determine the best model. Our results indicate that bluefin CPUE had higher spatiotemporal variability as compared to yellowfin CPUE. Bluefin CPUE increased substantially during the breeding months (March-June) and peaked in April and May, while yellowfin CPUE remained relatively high throughout the year. In addition, bluefin CPUE was significantly higher in areas with negative sea surface height anomalies and cooler sea surface temperatures, which are characteristic of mesoscale cyclonic eddies. In contrast, yellowfin CPUE was less sensitive to environmental variability. These differences in seasonal variability and sensitivity to environmental influences suggest that bluefin tuna bycatch in the GOM can be reduced substantially by managing the spatial and temporal distribution of the pelagic longline effort without substantially impacting yellowfin tuna catches. PMID:20526356

20 CFR 641.140 - What definitions apply to this part?

Code of Federal Regulations, 2010 CFR

2010-04-01

... counseling and assistance and financial counseling; library, recreational, and other similar services...-pollution and environmental quality efforts; weatherization activities; and economic development. (OAA sec... activities of daily living without substantial human assistance, including verbal reminding, physical cueing...

Air Traffic Control: Status of FAA's Standard Terminal Automation Replacement System Project

DOT National Transportation Integrated Search

1997-03-01

Since the early 1980s, FAA's modernization efforts have experienced lengthy : schedule delays and substantial cost overruns. Because of such problems, in : 1994, FAA restructured its acquisition of the Terminal Advanced Automation : System into more ...

Bridging the Gap: A Framework and Strategies for Integrating the Quality and Safety Mission of Teaching Hospitals and Graduate Medical Education.

PubMed

Tess, Anjala; Vidyarthi, Arpana; Yang, Julius; Myers, Jennifer S

2015-09-01

Integrating the quality and safety mission of teaching hospitals and graduate medical education (GME) is a necessary step to provide the next generation of physicians with the knowledge, skills, and attitudes they need to participate in health system improvement. Although many teaching hospital and health system leaders have made substantial efforts to improve the quality of patient care, few have fully included residents and fellows, who deliver a large portion of that care, in their efforts. Despite expectations related to the engagement of these trainees in health care quality improvement and patient safety outlined by the Accreditation Council for Graduate Medical Education in the Clinical Learning Environment Review program, a structure for approaching this integration has not been described.In this article, the authors present a framework that they hope will assist teaching hospitals in integrating residents and fellows into their quality and safety efforts and in fostering a positive clinical learning environment for education and patient care. The authors define the six essential elements of this framework-organizational culture, teaching hospital-GME alignment, infrastructure, curricular resources, faculty development, and interprofessional collaboration. They then describe the organizational characteristics required for each element and offer concrete strategies to achieve integration. This framework is meant to be a starting point for the development of robust national models of infrastructure, alignment, and collaboration between GME and health care quality and safety leaders at teaching hospitals.

Collecting costs of community prevention programs: communities putting prevention to work initiative.

PubMed

Khavjou, Olga A; Honeycutt, Amanda A; Hoerger, Thomas J; Trogdon, Justin G; Cash, Amanda J

2014-08-01

Community-based programs require substantial investments of resources; however, evaluations of these programs usually lack analyses of program costs. Costs of community-based programs reported in previous literature are limited and have been estimated retrospectively. To describe a prospective cost data collection approach developed for the Communities Putting Prevention to Work (CPPW) program capturing costs for community-based tobacco use and obesity prevention strategies. A web-based cost data collection instrument was developed using an activity-based costing approach. Respondents reported quarterly expenditures on labor; consultants; materials, travel, and services; overhead; partner efforts; and in-kind contributions. Costs were allocated across CPPW objectives and strategies organized around five categories: media, access, point of decision/promotion, price, and social support and services. The instrument was developed in 2010, quarterly data collections took place in 2011-2013, and preliminary analysis was conducted in 2013. Preliminary descriptive statistics are presented for the cost data collected from 51 respondents. More than 50% of program costs were for partner organizations, and over 20% of costs were for labor hours. Tobacco communities devoted the majority of their efforts to media strategies. Obesity communities spent more than half of their resources on access strategies. Collecting accurate cost information on health promotion and disease prevention programs presents many challenges. The approach presented in this paper is one of the first efforts successfully collecting these types of data and can be replicated for collecting costs from other programs. Copyright © 2014 American Journal of Preventive Medicine. All rights reserved.

Reexamining the Underrepresentation of Indigenous Peoples in Astronomy: A Hawaiian Case Study

NASA Astrophysics Data System (ADS)

Slater, Stephanie J.; Slater, Timothy F.

2015-08-01

As we look toward a future of ever increasing challenges in astronomy, there is widespread consensus that solutions depend on expanding human capitol. While we contemplate pathways to increase astronomy/STEM capacity across multinational settings, we are theoretically hindered by our failure to fully develop the capacity of ethnic and racial groups. Indigenous peoples continue to be underrepresented in astronomy at one-sixth of their share of the total U.S. population, despite investment of substantial resources from the public and private sectors. At the extreme, Native Hawaiians participate in astronomy at rates that are almost incalculably low. This 14-year case study of astronomy in the Hawaiian context suggests that national efforts (e.g. standards-based reform and agency-funded education and public outreach) have been, and are likely to continue to be, ineffective, as these efforts do not address the source of the problem. An examination of K-12, informal science, and "broader impacts" settings in Hawai'i, suggest that the disparity is ultimately rooted in a failure of relationships. Research across these settings indicates that many current common-sense efforts fail to transmit across cultures, and that effective efforts must primarily foster authentic trust and respect between Western and Indigenous perspective-holders. Specifically, findings suggest that much of our failure has been a result of human resource decisions. Although extensive research on effective practices at the indigenous/mainstream culture interface suggests that appropriate “bridge” persons are essential to creating authentic trust and respect between groups, in the Hawaiian context, we have often failed to do the work required to employ and empower “bridge” people. With critical examination of best- and worst-practices, this session focuses on immediate actions that can be taken to positively impact diverse participation in astronomy.

LSST Telescope and Optics Status

NASA Astrophysics Data System (ADS)

Krabbendam, Victor; Gressler, W. J.; Andrew, J. R.; Barr, J. D.; DeVries, J.; Hileman, E.; Liang, M.; Neill, D. R.; Sebag, J.; Wiecha, O.; LSST Collaboration

2011-01-01

The LSST Project continues to advance the design and development of an observatory system capable of capturing 20,000 deg2 of the sky in six wavebands over ten years. Optical fabrication of the unique M1/M3 monolithic mirror has entered final front surface optical processing. After substantial grinding to remove 5 tons of excess glass above the M3 surface, a residual of a single spin casting, both distinct optical surfaces are now clearly evident. Loose abrasive grinding has begun and polishing is to occur during 2011 and final optical testing is planned in early 2012. The M1/M3 telescope cell and internal component designs have matured to support on telescope operational requirements and off telescope coating needs. The mirror position system (hardpoint actuators) and mirror support system (figure actuator) designs have developed through internal laboratory analysis and testing. Review of thermal requirements has assisted with definition of a thermal conditioning and control system. Pre-cooling the M1/M3 substrate will enable productive observing during the large temperature swing often seen at twilight. The M2 ULE™ substrate is complete and lies in storage waiting for additional funding to enable final optical polishing. This 3.5m diameter, 100mm thick meniscus substrate has been ground to within 40 microns of final figure. Detailed design of the telescope mount, including subflooring, has been developed. Finally, substantial progress has been achieved on the facility design. In early 2010, LSST contracted with ARCADIS Geotecnica Consultores, a Santiago based engineering firm to lead the formal architectural design effort for the summit facility.

Overview of the determinants of overweight and obesity: current evidence and research issues.

PubMed

Hill, J O; Melanson, E L

1999-11-01

The prevalence of obesity has reached epidemic proportions in many countries around the world. However, the genetic and environmental factors contributing to obesity are incompletely understood. We reviewed studies relating to the regulation of energy balance and how these factors may contribute to the development of obesity. Although it is widely believed that genetics contribute significantly to the variability in body fatness, the available data do not support a role for defects in resting metabolic rate, substrate metabolism, dietary induced thermogenesis, or the energy cost of physical activity as significant causes of obesity. Furthermore, it is safe to say that the human genotype has not changed substantially over the past two to three decades. Data from several national surveys indicate that over the past few decades, there has been either a slight increase or a very modest decline in total energy and fat intake. This suggests that decreases in physical activity are a major contributing factor. Participation in leisure time physical activity is low but has remained relatively constant. However, an increased reliance on technology has substantially reduced work-related physical activity and the energy expenditure required for daily living. The most likely environmental factor contributing to the current obesity epidemic is a continued decline in daily energy expenditure that has not been matched by an equivalent reduction in energy intake. Because daily energy expenditure is decreasing, it is difficult for most people to restrict intake to meet energy requirements, and more and more people are becoming obese. Thus, increasing physical activity may be the strategy of choice for public health efforts to prevent obesity.

Limited indications of tax stamp discordance and counterfeiting on cigarette packs purchased in tobacco retailers, 97 counties, USA, 2012.

PubMed

Lee, Joseph G L; Golden, Shelley D; Ribisl, Kurt M

2017-12-01

Increasing the per-unit cost of tobacco products is one of the strongest interventions for tobacco control. In jurisdictions with higher taxes in the U.S., however, cigarette pack litter studies show a substantial proportion of littered packs lack the appropriate tax stamp. More limited but still present counterfeiting also exists. We sought to examine the role of tobacco retailers as a source for untaxed and counterfeit products. Data collectors purchased Newport Green (menthol) or Marlboro Red cigarette packs in a national probability-based sample of tobacco retailers (in 97 counties) from June-October 2012. They made no effort to buy counterfeit or untaxed cigarettes. In this cross-sectional study, we assessed the presence, tax authority, and type (low-tech thermal vs. encrypted) of cigarette pack tax stamps; concordance of tax stamps with where the pack was purchased; and, for Marlboro cigarettes, publicly available visible indicators of counterfeiting. We purchased 2147 packs of which 2033 had tax stamps. Packs missing stamps were in states that do not require them. We found very limited discordance between store location and tax stamp(s) (< 1%). However, a substantial minority of cigarette packs had damaged tax stamps (13%). This occurred entirely with low-tech tax stamps and was not identified with encrypted tax stamps. We found no clear evidence of counterfeit products. Almost all tax stamps matched the location of purchase. Litter studies may be picking up legal tax avoidance instead of illegal tax evasion or, alternatively, purchase of illicit products requires special request by the purchaser.

Understanding and predicting ecological dynamics: Are major surprises inevitable

USGS Publications Warehouse

Doak, Daniel F.; Estes, James A.; Halpern, Benjamin S.; Jacob, Ute; Lindberg, D.R.; Lovvorn, James R.; Monson, Daniel H.; Tinker, M. Tim; Williams, Terrie M.; Wootton, J. Timothy; Carroll, Ian; Emmerson, Mark; Micheli, Fiorenza; Novak, Mark

2008-01-01

Ecological surprises, substantial and unanticipated changes in the abundance of one or more species that result from previously unsuspected processes, are a common outcome of both experiments and observations in community and population ecology. Here, we give examples of such surprises along with the results of a survey of well-established field ecologists, most of whom have encountered one or more surprises over the course of their careers. Truly surprising results are common enough to require their consideration in any reasonable effort to characterize nature and manage natural resources. We classify surprises as dynamic-, pattern-, or intervention-based, and we speculate on the common processes that cause ecological systems to so often surprise us. A long-standing and still growing concern in the ecological literature is how best to make predictions of future population and community dynamics. Although most work on this subject involves statistical aspects of data analysis and modeling, the frequency and nature of ecological surprises imply that uncertainty cannot be easily tamed through improved analytical procedures, and that prudent management of both exploited and conserved communities will require precautionary and adaptive management approaches.

Going glass to digital: virtual microscopy as a simulation-based revolution in pathology and laboratory science.

PubMed

Nelson, Danielle; Ziv, Amitai; Bandali, Karim S

2012-10-01

The recent technological advance of digital high resolution imaging has allowed the field of pathology and medical laboratory science to undergo a dramatic transformation with the incorporation of virtual microscopy as a simulation-based educational and diagnostic tool. This transformation has correlated with an overall increase in the use of simulation in medicine in an effort to address dwindling clinical resource availability and patient safety issues currently facing the modern healthcare system. Virtual microscopy represents one such simulation-based technology that has the potential to enhance student learning and readiness to practice while revolutionising the ability to clinically diagnose pathology collaboratively across the world. While understanding that a substantial amount of literature already exists on virtual microscopy, much more research is still required to elucidate the full capabilities of this technology. This review explores the use of virtual microscopy in medical education and disease diagnosis with a unique focus on key requirements needed to take this technology to the next level in its use in medical education and clinical practice.

Republished: going glass to digital: virtual microscopy as a simulation-based revolution in pathology and laboratory science.

PubMed

Nelson, Danielle; Ziv, Amitai; Bandali, Karim S

2013-10-01

The recent technological advance of digital high resolution imaging has allowed the field of pathology and medical laboratory science to undergo a dramatic transformation with the incorporation of virtual microscopy as a simulation-based educational and diagnostic tool. This transformation has correlated with an overall increase in the use of simulation in medicine in an effort to address dwindling clinical resource availability and patient safety issues currently facing the modern healthcare system. Virtual microscopy represents one such simulation-based technology that has the potential to enhance student learning and readiness to practice while revolutionising the ability to clinically diagnose pathology collaboratively across the world. While understanding that a substantial amount of literature already exists on virtual microscopy, much more research is still required to elucidate the full capabilities of this technology. This review explores the use of virtual microscopy in medical education and disease diagnosis with a unique focus on key requirements needed to take this technology to the next level in its use in medical education and clinical practice.

The role of meat in strategies to achieve a sustainable diet lower in greenhouse gas emissions: A review.

PubMed

Hyland, John J; Henchion, Maeve; McCarthy, Mary; McCarthy, Sinéad N

2017-10-01

Food consumption is responsible for a considerable proportion of greenhouse gas emissions (GHGE). Hence, individual food choices have the potential to substantially influence both public health and the environment. Meat and animal products are relatively high in GHGE and therefore targeted in efforts to reduce dietary emissions. This review first highlights the complexities regarding sustainability in terms of meat consumption and thereafter discusses possible strategies that could be implemented to mitigate its climatic impact. It outlines how sustainable diets are possible without the elimination of meat. For instance, overconsumption of food in general, beyond our nutritional requirements, was found to be a significant contributor of emissions. Non-voluntary and voluntary mitigation strategies offer potential to reduce dietary GHGE. All mitigation strategies require careful consideration but on-farm sustainable intensification perhaps offers the most promise. However, a balance between supply and demand approaches is encouraged. Health should remain the overarching principle for policies and strategies concerned with shifting consumer behaviour towards sustainable diets. Copyright © 2017. Published by Elsevier Ltd.

Computation of turbulent boundary layers employing the defect wall-function method. M.S. Thesis

NASA Technical Reports Server (NTRS)

Brown, Douglas L.

1994-01-01

In order to decrease overall computational time requirements of spatially-marching parabolized Navier-Stokes finite-difference computer code when applied to turbulent fluid flow, a wall-function methodology, originally proposed by R. Barnwell, was implemented. This numerical effort increases computational speed and calculates reasonably accurate wall shear stress spatial distributions and boundary-layer profiles. Since the wall shear stress is analytically determined from the wall-function model, the computational grid near the wall is not required to spatially resolve the laminar-viscous sublayer. Consequently, a substantially increased computational integration step size is achieved resulting in a considerable decrease in net computational time. This wall-function technique is demonstrated for adiabatic flat plate test cases from Mach 2 to Mach 8. These test cases are analytically verified employing: (1) Eckert reference method solutions, (2) experimental turbulent boundary-layer data of Mabey, and (3) finite-difference computational code solutions with fully resolved laminar-viscous sublayers. Additionally, results have been obtained for two pressure-gradient cases: (1) an adiabatic expansion corner and (2) an adiabatic compression corner.

Fluid management in the optimization of space construction

NASA Technical Reports Server (NTRS)

Snyder, Howard

1990-01-01

Fluid management impacts strongly on the optimization of space construction. Large quantities of liquids are needed for propellants and life support. The mass of propellant liquids is comparable to that required for the structures. There may be a strong dynamic interaction between the stored liquids and the space structure unless the design minimizes the interaction. The constraints of cost and time required optimization of the supply/resupply strategy. The proper selection and design of the fluid management methods for: slosh control; stratification control; acquisition; transfer; gauging; venting; dumping; contamination control; selection of tank configuration and size; the storage state and the control system can improve the entire system performance substantially. Our effort consists of building mathematical/computer models of the various fluid management methods and testing them against the available experimental data. The results of the models are used as inputs to the system operations studies. During the past year, the emphasis has been on modeling: the transfer of cryogens; sloshing and the storage configuration. The work has been intermeshed with ongoing NASA design and development studies to leverage the funds provided by the Center.

Characteristics of 32 Supercentenarians

PubMed Central

Schoenhofen, Emily A.; Wyszynski, Diego F.; Andersen, Stacy; Pennington, JaeMi; Young, Robert; Terry, Dellara F.; Perls, Thomas T.

2010-01-01

OBJECTIVES To report phenotypic characteristics of 32 age-validated supercentenarians. DESIGN Case series. SETTING U.S.-based recruitment effort. PARTICIPANTS Thirty-two supercentenarians. MEASUREMENTS Multiple forms of proof were used to validate age claims. Sociodemographic, activities of daily living, and medical history data were collected. RESULTS Age range was 110 to 119. Fifty-nine percent had Barthel Index scores in the partially to totally dependent range, whereas 41% required minimal assistance or were independent. Few subjects had a history of clinically evident vascular-related diseases, including myocardial infarction (n = 2, 6%) and stroke (n = 4, 13%). Twenty-two percent (n = 7) were taking medications for hypertension. Twenty-five percent (n = 8) had a history of cancer (all cured). Diabetes mellitus (n = 1, 3%) and Parkinson’s disease (n = 1, 3%) were rare. Osteoporosis (n = 14, 44%) and cataract history (n = 28, 88%) were common. CONCLUSION Data collected thus far suggest that supercentenarians markedly delay and even escape clinical expression of vascular disease toward the end of their exceptionally long lives. A surprisingly substantial proportion of these individuals were still functionally independent or required minimal assistance. PMID:16913991

Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?

PubMed

Jones, Peter D; Stelzle, Martin

2016-01-01

Artificial chemical stimulation could provide improvements over electrical neurostimulation. Physiological neurotransmission between neurons relies on the nanoscale release and propagation of specific chemical signals to spatially-localized receptors. Current knowledge of nanoscale fluid dynamics and nanofluidic technology allows us to envision artificial mechanisms to achieve fast, high resolution neurotransmitter release. Substantial technological development is required to reach this goal. Nanofluidic technology-rather than microfluidic-will be necessary; this should come as no surprise given the nanofluidic nature of neurotransmission. This perspective reviews the state of the art of high resolution electrical neuroprostheses and their anticipated limitations. Chemical release rates from nanopores are compared to rates achieved at synapses and with iontophoresis. A review of microfluidic technology justifies the analysis that microfluidic control of chemical release would be insufficient. Novel nanofluidic mechanisms are discussed, and we propose that hydrophobic gating may allow control of chemical release suitable for mimicking neurotransmission. The limited understanding of hydrophobic gating in artificial nanopores and the challenges of fabrication and large-scale integration of nanofluidic components are emphasized. Development of suitable nanofluidic technology will require dedicated, long-term efforts over many years.

Geographic information system development in the CARETS project

USGS Publications Warehouse

Mitchell, William B.; Fegeas, Robin G.; Fitzpatrick, Katherine A.; Hallam, Cheryl A.

1977-01-01

Experience in the development of a geographic information system to support the CARETS project has confirmed the considerable advantages that may accrue by paralleling the system development with a rational and balanced system production effort which permits the integration of the education and training of users with interim deliverable products to them. Those advantages include support for a long-term staff plan that recognizes substantial staff changes through system development and implementation, a fiscal plan that provides continuity in resources necessary for total system development, and a feedback system which allows the user to communicate his experiences in using the system. Thus far balance between system development and system production has not been achieved because of continuing large-scale spatial data processing requirements coupled with strong and insistent demands from users for immediately deliverable products from the system. That imbalance has refocussed staffing and fiscal plans from long-term system development to short- and near-term production requirements, continuously extends total system development time, and increases the possibility that later system development may reduce the usefulness of current interim products.

Factors for Generating Initial Construction Schedules

DTIC Science & Technology

1991-09-01

2.2.8 Approach at Stone & Webster Co. 15 2.2.9 Approach at Bechtel Co. 16 2.2.10 SIPEC 16 2.2.11 OARPLAN 16 2.2.12 Other Research Efforts 17 2.2.13...PEC’s (Primitive Elements of Construction). PEC’s are tasks associated with a single activity and performed by a single crew. 2.2.8 Approach at Stone ...Webster Co. Stone & Webster has invested substantial efforts to integrate the informational needs of different project participants. Their current

Advanced Extra-Vehicular Activity Pressure Garment Requirements Development

NASA Technical Reports Server (NTRS)

Ross, Amy; Aitchison, Lindsay; Rhodes, Richard

2015-01-01

The NASA Johnson Space Center advanced pressure garment technology development team is addressing requirements development for exploration missions. Lessons learned from the Z-2 high fidelity prototype development have reiterated that clear low-level requirements and verification methods reduce risk to the government, improve efficiency in pressure garment design efforts, and enable the government to be a smart buyer. The expectation is to provide requirements at the specification level that are validated so that their impact on pressure garment design is understood. Additionally, the team will provide defined verification protocols for the requirements. However, in reviewing exploration space suit high level requirements there are several gaps in the team's ability to define and verify related lower level requirements. This paper addresses the efforts in requirement areas such as mobility/fit/comfort and environmental protection (dust, radiation, plasma, secondary impacts) to determine the method by which the requirements can be defined and use of those methods for verification. Gaps exist at various stages. In some cases component level work is underway, but no system level effort has begun; in other cases no effort has been initiated to close the gap. Status of on-going efforts and potential approaches to open gaps are discussed.

High Throughput Transcriptomics: From screening to pathways

EPA Science Inventory

The EPA ToxCast effort has screened thousands of chemicals across hundreds of high-throughput in vitro screening assays. The project is now leveraging high-throughput transcriptomic (HTTr) technologies to substantially expand its coverage of biological pathways. The first HTTr sc...

20 CFR 402.90 - Exemption four for withholding records: Trade secrets and confidential commercial or financial...

Code of Federal Regulations, 2010 CFR

2010-04-01

... SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC § 402.90 Exemption... trade commodities and that can be said to be the end product of either innovation or substantial effort...

The Government Performance and Results Act: 1997 Governmentwide Implementation Will be Uneven

DOT National Transportation Integrated Search

1997-06-01

A consensus that the nation's persistent federal deficit must be addressed and that the effectiveness of federal programs must improve substantially has spurred widespread efforts in the executive branch and Congress to dramatically change the way th...

Automatic Vehicle Location: Successful Transit Applications

DOT National Transportation Integrated Search

2002-11-01

Belief in the value of AVL is substantiated by statements of benefits contained earlier in this study. Even so, none of the study agencies are making full use of the voluminous amount of AVL data automatically recorded by the system. Efforts to make ...

77 FR 11625 - Child Restraint Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

...),'' Stammen; Vehicle Research and Test Center, National Highway Traffic Safety Administration (September 2004... exceeded. However, during extensive post-NPRM booster seat testing, inconsistencies in the test protocol... substantial rulemaking and research efforts to try to address test variability. NHTSA investigated the ATD's...

ESR1 mutations as a mechanism for acquired endocrine resistance in breast cancer

PubMed Central

Jeselsohn, Rinath; Buchwalter, Gilles; De Angelis, Carmine; Brown, Myles; Schiff, Rachel

2016-01-01

Most breast cancers are estrogen receptor α (ER)-positive (+) and are treated with endocrine therapies targeting ER activity. Despite efforts, the mechanisms of the frequent clinical resistance to these therapies remain largely unknown. Several recent parallel studies unveiled gain-of-function recurrent ESR1 mutations in up to 20% of patients with metastatic ER+ disease who all received endocrine therapies, which for more cases included an aromatase inhibitor. These mutations, clustered in a hotspot within the ligand-binding domain (LBD), lead to ligand independent ER activity and tumor growth, partial resistance to tamoxifen and fulvestrant, and potentially increased metastatic capacity. Together, these findings suggest that the ESR1 LBD mutations account for acquired endocrine resistance in a substantial fraction of patients with metastatic disease. The absence of detectable ESR1 mutations in treatment-naïve disease and the correlation with the number of endocrine treatments indicate a clonal expansion of rare mutant clones, selected under the pressure of treatment. New technologies to detect low/ultra rare ESR1 mutations together with tissue and liquid biopsies are required to fully expose their clinical relevance in prognosis and treatment. Pre-clinical and clinical development of rationale-based novel therapeutic strategies to inhibit these mutants has the potential to substantially improve treatment outcomes. PMID:26122181

A comparison between the dynamics of horizontal and vertical axis offshore floating wind turbines.

PubMed

Borg, M; Collu, M

2015-02-28

The need to further exploit offshore wind resources in deeper waters has led to a re-emerging interest in vertical axis wind turbines (VAWTs) for floating foundation applications. However, there has been little effort to systematically compare VAWTs to the more conventional horizontal axis wind turbine (HAWT). This article initiates this comparison based on prime principles, focusing on the turbine aerodynamic forces and their impact on the floating wind turbine static and dynamic responses. VAWTs generate substantially different aerodynamic forces on the support structure, in particular, a potentially lower inclining moment and a substantially higher torque than HAWTs. Considering the static stability requirements, the advantages of a lower inclining moment, a lower wind turbine mass and a lower centre of gravity are illustrated, all of which are exploitable to have a less costly support structure. Floating VAWTs experience increased motion in the frequency range surrounding the turbine [number of blades]×[rotational speed] frequency. For very large VAWTs with slower rotational speeds, this frequency range may significantly overlap with the range of wave excitation forces. Quantitative considerations are undertaken comparing the reference NREL 5 MW HAWT with the NOVA 5 MW VAWT. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Data Movement Dominates: Advanced Memory Technology to Address the Real Exascale Power Problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergman, Keren

Energy is the fundamental barrier to Exascale supercomputing and is dominated by the cost of moving data from one point to another, not computation. Similarly, performance is dominated by data movement, not computation. The solution to this problem requires three critical technologies: 3D integration, optical chip-to-chip communication, and a new communication model. The central goal of the Sandia led "Data Movement Dominates" project aimed to develop memory systems and new architectures based on these technologies that have the potential to lower the cost of local memory accesses by orders of magnitude and provide substantially more bandwidth. Only through these transformationalmore » advances can future systems reach the goals of Exascale computing with a manageable power budgets. The Sandia led team included co-PIs from Columbia University, Lawrence Berkeley Lab, and the University of Maryland. The Columbia effort of Data Movement Dominates focused on developing a physically accurate simulation environment and experimental verification for optically-connected memory (OCM) systems that can enable continued performance scaling through high-bandwidth capacity, energy-efficient bit-rate transparency, and time-of-flight latency. With OCM, memory device parallelism and total capacity can scale to match future high-performance computing requirements without sacrificing data-movement efficiency. When we consider systems with integrated photonics, links to memory can be seamlessly integrated with the interconnection network-in a sense, memory becomes a primary aspect of the interconnection network. At the core of the Columbia effort, toward expanding our understanding of OCM enabled computing we have created an integrated modeling and simulation environment that uniquely integrates the physical behavior of the optical layer. The PhoenxSim suite of design and software tools developed under this effort has enabled the co-design of and performance evaluation photonics-enabled OCM architectures on Exascale computing systems.« less

The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists

PubMed Central

Worden, Lila T.; Shahriari, Mona; Farrar, Andrew M.; Sink, Kelly S.; Hockemeyer, Jörg; Müller, Christa E.

2010-01-01

Rationale Brain dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired DA transmission reallocate their behavior away from food-seeking behaviors that have high response requirements, and instead select less effortful alternatives. Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related choice behavior, emerging evidence demonstrates a role for adenosine A2A receptors. Objective Adenosine A2A receptor antagonism has been shown to reverse the effects of DA antagonism. The present experiments were conducted to determine if this effect was dependent upon the subtype of DA receptor that was antagonized to produce the changes in effort-related choice. Materials and methods The adenosine A2A receptor antagonist MSX-3 (0.5–2.0 mg/kg IP) was assessed for its ability to reverse the effects of the D1 family antagonist SCH39166 (ecopipam; 0.2 mg/kg IP) and the D2 family antagonist eticlopride (0.08 mg/kg IP), using a concurrent lever pressing/chow feeding procedure. Results MSX-3 produced a substantial dose-related reversal of the effects of eticlopride on lever pressing and chow intake. At the highest dose of MSX-3, there was a complete reversal of the effects of eticlopride on lever pressing. In contrast, MSX-3 produced only a minimal attenuation of the effects of SCH39166, as measured by regression and effect size analyses. Conclusions The greater ability of MSX-3 to reverse the effects of D2 vs. D1 blockade may be related to the colocalization of D2 and adenosine A2A receptors on the same population of striatal neurons. PMID:19048234

Electrofishing effort requirements for estimating species richness in the Kootenai River, Idaho

USGS Publications Warehouse

Watkins, Carson J.; Quist, Michael C.; Shepard, Bradley B.; Ireland, Susan C.

2016-01-01

This study was conducted on the Kootenai River, Idaho to provide insight on sampling requirements to optimize future monitoring effort associated with the response of fish assemblages to habitat rehabilitation. Our objective was to define the electrofishing effort (m) needed to have a 95% probability of sampling 50, 75, and 100% of the observed species richness and to evaluate the relative influence of depth, velocity, and instream woody cover on sample size requirements. Sidechannel habitats required more sampling effort to achieve 75 and 100% of the total species richness than main-channel habitats. The sampling effort required to have a 95% probability of sampling 100% of the species richness was 1100 m for main-channel sites and 1400 m for side-channel sites. We hypothesized that the difference in sampling requirements between main- and side-channel habitats was largely due to differences in habitat characteristics and species richness between main- and side-channel habitats. In general, main-channel habitats had lower species richness than side-channel habitats. Habitat characteristics (i.e., depth, current velocity, and woody instream cover) were not related to sample size requirements. Our guidelines will improve sampling efficiency during monitoring effort in the Kootenai River and provide insight on sampling designs for other large western river systems where electrofishing is used to assess fish assemblages.

Pharmacogenetics of schizophrenia.

PubMed

Reynolds, Gavin P; Templeman, Lucy A; Godlewska, Beata R

2006-08-01

There is substantial unexplained interindividual variability in the drug treatment of schizophrenia. A substantial proportion of patients respond inadequately to antipsychotic drugs, and many experience limiting side effects. As genetic factors are likely to contribute to this variability, the pharmacogenetics of schizophrenia has attracted substantial effort. The approaches have mainly been limited to association studies of polymorphisms in candidate genes, which have been indicated by the pharmacology of antipsychotic drugs. Although some advances have been made, particularly in understanding the pharmacogenetics of some limiting side effects, genetic prediction of symptom response remains elusive. Nevertheless, with improvements in defining the response phenotype in carefully assessed and homogeneous subject groups, the near future is likely to see the identification of genetic predictors of outcome that may inform the choice of pharmacotherapy.

The Mechanisms of Alcohol Control

PubMed Central

Carpenter, Christopher S.; Dobkin, Carlos; Warman, Casey

2015-01-01

A substantial economics literature documents that tighter alcohol controls reduce alcohol-related harms, but far less is known about mechanisms. We use the universe of Canadian mortality records to document that Canada’s Minimum Legal Drinking Age (MLDA) significantly reduces mortality rates of young men but has much smaller effects on women. Using drinking data that are far more detailed than in prior work, we document that the MLDA substantially reduces ‘extreme’ drinking among men but not women. Our results suggest that alcohol control efforts targeting young adults should focus on reducing extreme drinking behavior. PMID:27127308

20180311 - High Throughput Transcriptomics: From screening to pathways (SOT 2018)

EPA Science Inventory

The EPA ToxCast effort has screened thousands of chemicals across hundreds of high-throughput in vitro screening assays. The project is now leveraging high-throughput transcriptomic (HTTr) technologies to substantially expand its coverage of biological pathways. The first HTTr sc...

Probabilistic Prediction of Riverine Bathymetry

DTIC Science & Technology

2011-09-30

planned a substantial data field collection effort on the Hanford Reach of the Columbia River near Richland, WA, which represents an ideal testing...4 Figure 2. 82-km Hanford Reach of the Columbia River (WA) IMPACT/APPLICATIONS The developed methods are directly applicable to video

Gene expression analysis between planktonic and biofilm states of Flavobacterium columnare

USDA-ARS?s Scientific Manuscript database

Flavobacterium columnare, the causative agent of columnaris disease causes substantial mortality worldwide in numerous freshwater finfish species. Due to its global significance and impact on the aquaculture industry continual efforts to better understand basic mechanisms that contribute to disease ...

29 CFR 825.215 - Equivalent position.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Equivalent position. 825.215 Section 825.215 Labor....215 Equivalent position. (a) Equivalent position. An equivalent position is one that is virtually... responsibilities, which must entail substantially equivalent skill, effort, responsibility, and authority. (b...

29 CFR 825.215 - Equivalent position.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Equivalent position. 825.215 Section 825.215 Labor....215 Equivalent position. (a) Equivalent position. An equivalent position is one that is virtually... responsibilities, which must entail substantially equivalent skill, effort, responsibility, and authority. (b...

29 CFR 825.215 - Equivalent position.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Equivalent position. 825.215 Section 825.215 Labor....215 Equivalent position. (a) Equivalent position. An equivalent position is one that is virtually... responsibilities, which must entail substantially equivalent skill, effort, responsibility, and authority. (b...

29 CFR 825.215 - Equivalent position.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Equivalent position. 825.215 Section 825.215 Labor....215 Equivalent position. (a) Equivalent position. An equivalent position is one that is virtually... responsibilities, which must entail substantially equivalent skill, effort, responsibility, and authority. (b...

29 CFR 825.215 - Equivalent position.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Equivalent position. 825.215 Section 825.215 Labor....215 Equivalent position. (a) Equivalent position. An equivalent position is one that is virtually... responsibilities, which must entail substantially equivalent skill, effort, responsibility, and authority. (b...

Sickeningly sweet: L-rhamnose stimulates Flavobacterium columnare biofilm formation and virulence

USDA-ARS?s Scientific Manuscript database

Flavobacterium columnare, the causative agent of columnaris disease causes substantial mortality worldwide in numerous freshwater finfish species. Due to its global significance and impact on the aquaculture industry continual efforts to better understand basic mechanisms that contribute to disease ...

The carbohydrate L-rhamnose promotes biofilm formation which enhances Flavobacterium columnare virulence

USDA-ARS?s Scientific Manuscript database

Flavobacterium columnare, the causative agent of columnaris disease causes substantial mortality worldwide in numerous freshwater finfish species. Due to its global significance and impact on the aquaculture industry, continual efforts to better understand basic mechanisms that contribute to disease...

Effort, symptom validity testing, performance validity testing and traumatic brain injury.

PubMed

Bigler, Erin D

2014-01-01

To understand the neurocognitive effects of brain injury, valid neuropsychological test findings are paramount. This review examines the research on what has been referred to a symptom validity testing (SVT). Above a designated cut-score signifies a 'passing' SVT performance which is likely the best indicator of valid neuropsychological test findings. Likewise, substantially below cut-point performance that nears chance or is at chance signifies invalid test performance. Significantly below chance is the sine qua non neuropsychological indicator for malingering. However, the interpretative problems with SVT performance below the cut-point yet far above chance are substantial, as pointed out in this review. This intermediate, border-zone performance on SVT measures is where substantial interpretative challenges exist. Case studies are used to highlight the many areas where additional research is needed. Historical perspectives are reviewed along with the neurobiology of effort. Reasons why performance validity testing (PVT) may be better than the SVT term are reviewed. Advances in neuroimaging techniques may be key in better understanding the meaning of border zone SVT failure. The review demonstrates the problems with rigidity in interpretation with established cut-scores. A better understanding of how certain types of neurological, neuropsychiatric and/or even test conditions may affect SVT performance is needed.

The impact of patient advocacy: the University of California-San Francisco experience.

PubMed

Carroll, Peter R

2004-11-01

Although the principal goals of health care advocacy are to raise awareness of specific issues and make them national priorities, it is important that physicians should recognize that advocacy is a multidimensional phenomenon. In 1997 a group of scientists, administrators, clinicians and patients met to discuss individual goals, needs and areas of mutual interest in the areas of prostate cancer care and research. A formal advocacy group was established and advocates were integrated into the administration and planning process in specific areas of the clinical and research program. In an effort to quantitate and communicate the impact of this group we assessed outcomes in the last 5 years in 4 areas matched to group interests and priorities, namely research, clinical trials, patient services and philanthropy. Improvements in all assessed metrics were noted (18% to 1,796%), most substantially in the areas of research grants (286%) and philanthropy (1,796%). The highlight of the collaborative effort was the awarding of the University of California-San Francisco Prostate Cancer SPORE, which included a highly rated, formal advocacy core. Advocates initiated at least 25 new initiatives to improve patient services in the areas of access to care, patient education, psychosocial support, outreach, etc. Since the initiation of a prostate cancer advocacy effort at our institution, substantial and quantitative improvements in several key metrics have been identified. Although an exact cause and effect cannot be stated with certainty, it seems likely. The successful collaboration was based on a multidimensional patient advocacy effort.

26 CFR 1.162-17 - Reporting and substantiation of certain business expenses of employees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Commissioner may require any taxpayer to substantiate such information concerning expense accounts as may... substantiate expense account information except those in the following categories: (i) A taxpayer who is not... advantage of taxpayers who may be called upon to substantiate expense account information to maintain as...

Trade and health: an agenda for action.

PubMed

Smith, Richard D; Lee, Kelley; Drager, Nick

2009-02-28

The processes of contemporary globalisation are creating ever-closer ties between individuals and populations across different countries. The health of a population, and the systems in place to deliver health care, are affected increasingly by factors beyond the population and health system. The Lancet's Series on trade and health has provided an overview of these links between international trade, trade liberalisation, and health, and raised the key issues that face the health community. In this final paper in the Series, we call for a substantial and sustained effort by those within the health profession to engage with issues of trade, to strengthen institutional capacity in this area, and to place health higher on the agenda of trade negotiations. The rapid rise of trade agreements and treaties, as well as trade that occurs beyond these institutional boundaries, means that further action is required by a range of actors, including WHO, the World Bank, the World Trade Organization (WTO), regional agencies, foundations, national governments, civil society, non-governmental organisations, and academics. The stewardship of a domestic health system in the 21st century requires a sophisticated understanding of how trade affects, and will affect, a country's health system and policy, to optimise opportunities to benefit health and health care while minimising the risks posed though the assertion of health goals in trade policy. To acheive this will place a premium on all those engaged in health to understand the importance of trade and to engage with their counterparts involved in trade and trade policy. We hope that this Series has prompted the reader to become involved in these efforts.

Proceedings of the July 2011 Traceability Research Summit.

PubMed

Newsome, Rosetta L; Bhatt, Tejas; McEntire, Jennifer C

2013-12-01

At a discussion-based forum of 50 leaders in the area of food product tracing, participants recognized the need for the development of a common vision for a simple, low cost and implementable traceability approach. A key theme that emerged during the day's discussions revolved around not reinventing the wheel: there are many efforts underway, including numerous pilots, and these efforts should be collaborative. The group sought more information on current initiatives and felt that learning from the experiences of others could help form a realistic vision for the future. Although any forthcoming actions from the US FDA are unknown, industry fully expects that improvements in product tracing will be necessary, and expects that industry itself (through the "demand" side) will enact requirements that may surpass regulatory mandates. A chief concern is uniform adoption, which will require outreach to and support from the global community as well as small firms that may lack the resources and education to keep up. Ultimately, an approach that is global, economical, scalable, and inclusive of firms of all sizes who handles all types of food products, will have the greatest likelihood of success. While the ability to rapidly link products across the supply chain serves as an ideal goal, there are still substantial concerns to be addressed, particularly regarding confidentiality of data, and who will have access to what information under what circumstances, which was woven into virtually every discussion topic. Who will spearhead the development of the visions is a question, but there was general agreement that a joint partnership which includes all stakeholders is a necessity. © 2012 Institute of Food Technologists®

Trade and health: an agenda for action

PubMed Central

Smith, Richard D; Lee, Kelley; Drager, Nick

2009-01-01

The processes of contemporary globalisation are creating ever-closer ties between individuals and populations across different countries. The health of a population, and the systems in place to deliver health care, are affected increasingly by factors beyond the population and health system. The Lancet’s Series on trade and health has provided an overview of these links between international trade, trade liberalisation, and health, and raised the key issues that face the health community. In this final paper in the Series, we call for a substantial and sustained effort by those within the health profession to engage with issues of trade, to strengthen institutional capacity in this area, and to place health higher on the agenda of trade negotiations. The rapid rise of trade agreements and treaties, as well as trade that occurs beyond these institutional boundaries, means that further action is required by a range of actors, including WHO, the World Bank, the World Trade Organization (WTO), regional agencies, foundations, national governments, civil society, non-governmental organisations, and academics. The stewardship of a domestic health system in the 21st century requires a sophisticated understanding of how trade affects, and will affect, a country’s health system and policy, to optimise opportunities to benefit health and health care while minimising the risks posed though the assertion of health goals in trade policy. To acheive this will place a premium on all those engaged in health to understand the importance of trade and to engage with their counterparts involved in trade and trade policy. We hope that this Series has prompted the reader to become involved in these efforts. PMID:19167056

Study of aircraft in intraurban transportation systems, San Francisco Bay area

NASA Technical Reports Server (NTRS)

1972-01-01

The nine-county San Francisco Bay area is examined in two time periods (1975-1980 and 1985-1990) as a scenario for analyzing the characteristics of an intraurban, commuter-oriented aircraft transportation system. Aircraft have dominated the long-haul passenger market for some time, but efforts to penetrate the very-short-haul intraurban market have met with only token success. Yet, the characteristics of an aircraft transportation system, speed and flexibility, are very much needed to solve the transportation ills of our major urban areas. The aircraft intraurban system is a technically feasible alternative to ground transportation systems. Although requiring some subsidy, it becomes socially viable where substantial commuter traffic exists at ranges of 10 to 15 mi or more and where topographic features constrain ground travel. The general problem areas of community noise, air traffic congestion, ground transportation interface, pollution, and safety appear to have workable solutions.

Peer Tutoring to Prevent Firearm Play: Acquisition, Generalization, and Long-term Maintenance of Safety Skills

PubMed Central

Jostad, Candice M; Miltenberger, Raymond G; Kelso, Pamela; Knudson, Peter

2008-01-01

Hundreds of accidental injuries and deaths to children occur annually in the United States as a result of firearm play. Behavioral skills training (BST) and in situ training have been found to be effective in teaching children the skills to use if they find a firearm, but training requires substantial time and effort. The current study examined the use of peers as tutors as a potential way to decrease the time and resources needed to teach these safety skills to youngsters. Peer trainers conducted BST and in situ training with other children. Children taught by the peer trainers acquired the safety skills and demonstrated them in naturalistic situations in which the skills were needed. Furthermore, all of the peer trainers acquired and maintained the skills. These results support the use of peer tutoring for teaching safety skills to other children. PMID:18468285

The challenges of sequencing by synthesis.

PubMed

Fuller, Carl W; Middendorf, Lyle R; Benner, Steven A; Church, George M; Harris, Timothy; Huang, Xiaohua; Jovanovich, Stevan B; Nelson, John R; Schloss, Jeffery A; Schwartz, David C; Vezenov, Dmitri V

2009-11-01

DNA sequencing-by-synthesis (SBS) technology, using a polymerase or ligase enzyme as its core biochemistry, has already been incorporated in several second-generation DNA sequencing systems with significant performance. Notwithstanding the substantial success of these SBS platforms, challenges continue to limit the ability to reduce the cost of sequencing a human genome to $100,000 or less. Achieving dramatically reduced cost with enhanced throughput and quality will require the seamless integration of scientific and technological effort across disciplines within biochemistry, chemistry, physics and engineering. The challenges include sample preparation, surface chemistry, fluorescent labels, optimizing the enzyme-substrate system, optics, instrumentation, understanding tradeoffs of throughput versus accuracy, and read-length/phasing limitations. By framing these challenges in a manner accessible to a broad community of scientists and engineers, we hope to solicit input from the broader research community on means of accelerating the advancement of genome sequencing technology.

Test Activities in the Langley Transonic Dynamics Tunnel and a Summary of Recent Facility Improvements

NASA Technical Reports Server (NTRS)

Cole, Stanley R.; Johnson, R. Keith; Piatak, David J.; Florance, Jennifer P.; Rivera, Jose A., Jr.

2003-01-01

The Langley Transonic Dynamics Tunnel (TDT) has provided a unique capability for aeroelastic testing for over forty years. The facility has a rich history of significant contributions to the design of many United States commercial transports, military aircraft, launch vehicles, and spacecraft. The facility has many features that contribute to its uniqueness for aeroelasticity testing, perhaps the most important feature being the use of a heavy gas test medium to achieve higher test densities compared to testing in air. Higher test medium densities substantially improve model-building requirements and therefore simplify the fabrication process for building aeroelastically scaled wind tunnel models. This paper describes TDT capabilities that make it particularly suited for aeroelasticity testing. The paper also discusses the nature of recent test activities in the TDT, including summaries of several specific tests. Finally, the paper documents recent facility improvement projects and the continuous statistical quality assessment effort for the TDT.

Medicare+Choice: what lies ahead?

PubMed

Layne, R Jeffrey

2002-03-01

Health plans have continued to exit the Medicare+Choice program in recent years, despite efforts of Congress and the Centers for Medicare and Medicaid Services (CMS) to reform the program. Congress and CMS therefore stand poised to make additional, substantial reforms to the program. CMS has proposed to consolidate its oversight of the program, extend the due date for Medicare+Choice plans to file their adjusted community rate proposals, revise risk-adjustment processes, streamline the marketing review process, enhance quality-improvement requirements, institute results based performance assessment audits, coordinate policy changes to coincide with contracting cycles, expand its fall advertising campaign for the program, provide better employer-based Medicare options for beneficiaries, and take steps to minimize beneficiary costs. Congressional leaders have proposed various legislative remedies to improve the program, including creation of an entirely new pricing structure for the program based on a competitive bidding process.

Use of declarative statements in creating and maintaining computer-interpretable knowledge bases for guideline-based care.

PubMed

Tu, Samson W; Hrabak, Karen M; Campbell, James R; Glasgow, Julie; Nyman, Mark A; McClure, Robert; McClay, James; Abarbanel, Robert; Mansfield, James G; Martins, Susana M; Goldstein, Mary K; Musen, Mark A

2006-01-01

Developing computer-interpretable clinical practice guidelines (CPGs) to provide decision support for guideline-based care is an extremely labor-intensive task. In the EON/ATHENA and SAGE projects, we formulated substantial portions of CPGs as computable statements that express declarative relationships between patient conditions and possible interventions. We developed query and expression languages that allow a decision-support system (DSS) to evaluate these statements in specific patient situations. A DSS can use these guideline statements in multiple ways, including: (1) as inputs for determining preferred alternatives in decision-making, and (2) as a way to provide targeted commentaries in the clinical information system. The use of these declarative statements significantly reduces the modeling expertise and effort required to create and maintain computer-interpretable knowledge bases for decision-support purpose. We discuss possible implications for sharing of such knowledge bases.

Computer modelling of epilepsy.

PubMed

Lytton, William W

2008-08-01

Epilepsy is a complex set of disorders that can involve many areas of the cortex, as well as underlying deep-brain systems. The myriad manifestations of seizures, which can be as varied as déjà vu and olfactory hallucination, can therefore give researchers insights into regional functions and relations. Epilepsy is also complex genetically and pathophysiologically: it involves microscopic (on the scale of ion channels and synaptic proteins), macroscopic (on the scale of brain trauma and rewiring) and intermediate changes in a complex interplay of causality. It has long been recognized that computer modelling will be required to disentangle causality, to better understand seizure spread and to understand and eventually predict treatment efficacy. Over the past few years, substantial progress has been made in modelling epilepsy at levels ranging from the molecular to the socioeconomic. We review these efforts and connect them to the medical goals of understanding and treating the disorder.

Impact-generated Tsunamis: An Over-rated Hazard

NASA Technical Reports Server (NTRS)

Melosh, H. J.

2003-01-01

A number of authors have suggested that oceanic waves (tsunami) created by the impact of relatively small asteroids into the Earth's oceans might cause widespread devastation to coastal cities. If correct, this suggests that asteroids > 100 m in diameter may pose a serious hazard to humanity and could require a substantial expansion of the current efforts to identify earth-crossing asteroids > 1 km in diameter. The debate on this hazard was recently altered by the release of a document previously inaccessible to the scientific community. In 1968 the US Office of Naval Research commissioned a summary of several decades of research into the hazard proposed by waves generated by nuclear explosions in the ocean. Authored by tsunami expert William Van Dorn, this 173-page report entitled Handbook of Explosion-Generated Water Waves affords new insight into the process of impact wave formation, propagation, and run up onto the shoreline.

An overview of autonomous rendezvous and docking system technology development

NASA Astrophysics Data System (ADS)

Nelson, Kurt D.

The Centaur upper stage was selected for an airborne avionics modernization program. The parts used in the existing avionics units were obsolete. Continued use of existing hardware would require substantial redesign, yet would result in the use of outdated hardware. Out of date processes, with very expensive and labor intensive technologies, were being used for manufacturing. The Atlas/Centaur avionics were to be procured at a fairly high rate that demanded the use of modern components. The new avionics also reduce size, weight, power, and parts count with a dramatic improvement in reliability. Finally, the cost leverage derived from upgrading the avionics as opposed to any other subsystem for the existing Atlas/Centaur was a very large consideration in the upgrade decision. The upgrade program is a multiyear effort that began in 1989. It includes telemetry, guidance and navigation, control electronics, thrust vector control, and redundancy levels.

Obesity and weight management at menopause.

PubMed

Proietto, Joseph

2017-06-01

Many women report gaining weight as they transition through menopause. For most, the weight gain is modest and can be reduced with a conscious effort to limit energy intake and increase energy expenditure. However, many women who are already overweight and obese will gain more weight as they approach menopause. The aims of this paper are to explain the reasons for menopausal weight gain and to detail a method for achieving and sustaining a substantial weight loss. Weight gain during menopause is predominantly due to a reduction in spontaneous activity. For women who are lean, advice about controlling energy intake and increasing physical activity may be all that is required to prevent weight gain. For women who are overweight and obese rapid weight loss is best achieved with the help of a very low energy diet. This must be followed by lifelong behaviour modification with or without the help of hunger-suppressing pharmacotherapy.

A global standard for monitoring coastal wetland vulnerability to accelerated sea-level rise

USGS Publications Warehouse

Webb, Edward L.; Friess, Daniel A.; Krauss, Ken W.; Cahoon, Donald R.; Guntenspergen, Glenn R.; Phelps, Jacob

2013-01-01

Sea-level rise threatens coastal salt-marshes and mangrove forests around the world, and a key determinant of coastal wetland vulnerability is whether its surface elevation can keep pace with rising sea level. Globally, a large data gap exists because wetland surface and shallow subsurface processes remain unaccounted for by traditional vulnerability assessments using tide gauges. Moreover, those processes vary substantially across wetlands, so modelling platforms require relevant local data. The low-cost, simple, high-precision rod surface-elevation table–marker horizon (RSET-MH) method fills this critical data gap, can be paired with spatial data sets and modelling and is financially and technically accessible to every country with coastal wetlands. Yet, RSET deployment has been limited to a few regions and purposes. A coordinated expansion of monitoring efforts, including development of regional networks that could support data sharing and collaboration, is crucial to adequately inform coastal climate change adaptation policy at several scales.

Low-cost manufacturing of the point focus concentrating module and its key component, the Fresnel lens. Final subcontract report, 31 January 1991--6 May 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saifee, T.; Konnerth, A. III

1991-11-01

Solar Kinetics, Inc. (SKI) has been developing point-focus concentrating PV modules since 1986. SKI is currently in position to manufacture between 200 to 600 kilowatts annually of the current design by a combination of manual and semi-automated methods. This report reviews the current status of module manufacture and specifies the required approach to achieve a high-volume manufacturing capability and low cost. The approach taken will include process development concurrent with module design for automated manufacturing. The current effort reviews the major manufacturing costs and identifies components and processes whose improvements would produce the greatest effect on manufacturability and cost reduction.more » The Fresnel lens is one such key component. Investigating specific alternative manufacturing methods and sources has substantially reduced the lens costs and has exceeded the DOE cost-reduction goals. 15 refs.« less

What matters most: quantifying an epidemiology of consequence.

PubMed

Keyes, Katherine; Galea, Sandro

2015-05-01

Risk factor epidemiology has contributed to substantial public health success. In this essay, we argue, however, that the focus on risk factor epidemiology has led epidemiology to ever increasing focus on the estimation of precise causal effects of exposures on an outcome at the expense of engagement with the broader causal architecture that produces population health. To conduct an epidemiology of consequence, a systematic effort is needed to engage our science in a critical reflection both about how well and under what conditions or assumptions we can assess causal effects and also on what will truly matter most for changing population health. Such an approach changes the priorities and values of the discipline and requires reorientation of how we structure the questions we ask and the methods we use, as well as how we teach epidemiology to our emerging scholars. Copyright © 2015 Elsevier Inc. All rights reserved.

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia.

PubMed

Grist, Eric P M; Flegg, Jennifer A; Humphreys, Georgina; Mas, Ignacio Suay; Anderson, Tim J C; Ashley, Elizabeth A; Day, Nicholas P J; Dhorda, Mehul; Dondorp, Arjen M; Faiz, M Abul; Gething, Peter W; Hien, Tran T; Hlaing, Tin M; Imwong, Mallika; Kindermans, Jean-Marie; Maude, Richard J; Mayxay, Mayfong; McDew-White, Marina; Menard, Didier; Nair, Shalini; Nosten, Francois; Newton, Paul N; Price, Ric N; Pukrittayakamee, Sasithon; Takala-Harrison, Shannon; Smithuis, Frank; Nguyen, Nhien T; Tun, Kyaw M; White, Nicholas J; Witkowski, Benoit; Woodrow, Charles J; Fairhurst, Rick M; Sibley, Carol Hopkins; Guerin, Philippe J

2016-10-24

Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here we propose a generic 'smart surveillance' methodology to identify optimal candidate sites for future sampling and thus map the distribution of artemisinin resistance most efficiently. The approach uses the 'uncertainty' map generated iteratively by a geostatistical model to determine optimal locations for subsequent sampling. The methodology is illustrated using recent data on the prevalence of the K13-propeller polymorphism (a genetic marker of artemisinin resistance) in the Greater Mekong Subregion. This methodology, which has broader application to geostatistical mapping in general, could improve the quality and efficiency of drug resistance mapping and thereby guide practical operations to eliminate malaria in affected areas.

Comparative evaluation of surface and downhole steam-generation techniques

NASA Astrophysics Data System (ADS)

Hart, C.

The application of heat to reservoirs containing high API gravity oils can substantially improve recovery. Although steam injection is currently the principal thermal recovery method, heat transmission losses associated with delivery of the steam from the surface generators to the oil bearing formation has limited conventional steam injection to shallow reservoirs. The objective of the Department of Energy's Project DEEP STEAM is to develop the technology required to economically produce heavy oil from deep reservoirs. The tasks included in this effort are the development and evaluation of thermally efficient delivery systems and downhole steam generation systems. The technical and economic performance of conventional surface steam drives, which are strongly influenced by heat losses are compared. The selection of a preferred technology based upon either total efficiency or cost is found to be strongly influenced by reservoir depth, steam mass flow rate, and sandface steam quality.

The Use of Mock NSF-type Grant Proposals and Blind Peer Review as the Capstone Assignment in Upper-Level Neurobiology and Cell Biology Courses

PubMed Central

Itagaki, Haruhiko

2013-01-01

Although the use of grant proposals and blind peer review are standard in the natural sciences, their use as a pedagogical tool is rarely mentioned in the literature. As a consequence of dissatisfaction with term papers and literature reviews as the capstone writing experience in 300-level undergraduate biology courses, I have been experimenting with mock NSF-type grant proposals followed by blind peer review as the major assignment in my junior/senior-level classes. The improvement in educational outcomes and competencies due to this assignment appears to be substantial and worth the additional effort on both the students’ and instructor’s parts. Here, I outline the mechanics of this assignment and its advantages and disadvantages as well as the type of curriculum that is required to support this type of capstone assignment. PMID:24319395

Revised Point of Departure Design Options for Nuclear Thermal Propulsion

NASA Technical Reports Server (NTRS)

Fittje, James E.; Borowski, Stanley K.; Schnitzler, Bruce

2015-01-01

In an effort to further refine potential point of departure nuclear thermal rocket engine designs, four proposed engine designs representing two thrust classes and utilizing two different fuel matrix types are designed and analyzed from both a neutronics and thermodynamic cycle perspective. Two of these nuclear rocket engine designs employ a tungsten and uranium dioxide cermet (ceramic-metal) fuel with a prismatic geometry based on the ANL-200 and the GE-710, while the other two designs utilize uranium-zirconium-carbide in a graphite composite fuel and a prismatic fuel element geometry developed during the Rover/NERVA Programs. Two engines are analyzed for each fuel type, a small criticality limited design and a 111 kN (25 klbf) thrust class engine design, which has been the focus of numerous manned mission studies, including NASA's Design Reference Architecture 5.0. slightly higher T/W ratios, but they required substantially more 235U.

Topological distribution of four-alpha-helix bundles.

PubMed Central

Presnell, S R; Cohen, F E

1989-01-01

The four-alpha-helix bundle, a common structural motif in globular proteins, provides an excellent forum for the examination of predictive constraints for protein backbone topology. An exhaustive examination of the Brookhaven Crystallographic Protein Data Bank and other literature sources has lead to the discovery of 20 putative four-alpha-helix bundles. Application of an analytical method that examines the difference between solvent-accessible surface areas in packed and partially unpacked bundles reduced the number of structures to 16. Angular requirements further reduced the list of bundles to 13. In 12 of these bundles, all pairs of neighboring helices were oriented in an anti-parallel fashion. This distribution is in accordance with structure types expected if the helix macro dipole effect makes a substantial contribution to the stability of the native structure. The characterizations and classifications made in this study prompt a reevaluation of constraints used in structure prediction efforts. Images PMID:2771946

Protecting marine mammals, turtles, and birds by rebuilding global fisheries.

PubMed

Burgess, Matthew G; McDermott, Grant R; Owashi, Brandon; Peavey Reeves, Lindsey E; Clavelle, Tyler; Ovando, Daniel; Wallace, Bryan P; Lewison, Rebecca L; Gaines, Steven D; Costello, Christopher

2018-03-16

Reductions in global fishing pressure are needed to end overfishing of target species and maximize the value of fisheries. We ask whether such reductions would also be sufficient to protect non-target species threatened as bycatch. We compare changes in fishing pressure needed to maximize profits from 4713 target fish stocks-accounting for >75% of global catch-to changes in fishing pressure needed to reverse ongoing declines of 20 marine mammal, sea turtle, and seabird populations threatened as bycatch. We project that maximizing fishery profits would halt or reverse declines of approximately half of these threatened populations. Recovering the other populations would require substantially greater effort reductions or targeting improvements. Improving commercial fishery management could thus yield important collateral benefits for threatened bycatch species globally. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Control and Effort Costs Influence the Motivational Consequences of Choice

PubMed Central

Sullivan-Toole, Holly; Richey, John A.; Tricomi, Elizabeth

2017-01-01

The act of making a choice, apart from any outcomes the choice may yield, has, paradoxically, been linked to both the enhancement and the detriment of intrinsic motivation. Research has implicated two factors in potentially mediating these contradictory effects: the personal control conferred by a choice and the costs associated with a choice. Across four experiments, utilizing a physical effort task disguised as a simple video game, we systematically varied costs across two levels of physical effort requirements (Low-Requirement, High-Requirement) and control over effort costs across three levels of choice (Free-Choice, Restricted-Choice, and No-Choice) to disambiguate how these factors affect the motivational consequences of choosing within an effortful task. Together, our results indicated that, in the face of effort requirements, illusory control alone may not sufficiently enhance perceptions of personal control to boost intrinsic motivation; rather, the experience of actual control may be necessary to overcome effort costs and elevate performance. Additionally, we demonstrated that conditions of illusory control, while otherwise unmotivating, can through association with the experience of free-choice, be transformed to have a positive effect on motivation. PMID:28515705

Effort-Reward Imbalance, Work-Privacy Conflict, and Burnout Among Hospital Employees.

PubMed

Häusler, Nadine; Bopp, Matthias; Hämmig, Oliver

2018-04-01

Studies investigating the relative importance of effort-reward imbalance and work-privacy conflict for burnout risk between professional groups in the health care sector are rare and analyses by educational attainment within professional groups are lacking. The study population consists of 1422 hospital employees in Switzerland. Multivariate linear regression analyses with standardized coefficients were performed for the overall study population and stratified for professional groups refined for educational attainment. Work-privacy conflict is a strong predictor for burnout and more strongly associated with burnout than effort-reward imbalance in the overall study population and across all professional groups. Effort-reward imbalance only had a minor effect on burnout in tertiary-educated medical professionals. Interventions aiming at increasing the compatibility of work and private life may substantially help to decrease burnout risk of professionals working in a health care setting.

Towards an Early Software Effort Estimation Based on Functional and Non-Functional Requirements

NASA Astrophysics Data System (ADS)

Kassab, Mohamed; Daneva, Maya; Ormandjieva, Olga

The increased awareness of the non-functional requirements as a key to software project and product success makes explicit the need to include them in any software project effort estimation activity. However, the existing approaches to defining size-based effort relationships still pay insufficient attention to this need. This paper presents a flexible, yet systematic approach to the early requirements-based effort estimation, based on Non-Functional Requirements ontology. It complementarily uses one standard functional size measurement model and a linear regression technique. We report on a case study which illustrates the application of our solution approach in context and also helps evaluate our experiences in using it.

Measuring Listening Effort: Convergent Validity, Sensitivity, and Links With Cognitive and Personality Measures.

PubMed

Strand, Julia F; Brown, Violet A; Merchant, Madeleine B; Brown, Hunter E; Smith, Julia

2018-06-19

Listening effort (LE) describes the attentional or cognitive requirements for successful listening. Despite substantial theoretical and clinical interest in LE, inconsistent operationalization makes it difficult to make generalizations across studies. The aims of this large-scale validation study were to evaluate the convergent validity and sensitivity of commonly used measures of LE and assess how scores on those tasks relate to cognitive and personality variables. Young adults with normal hearing (N = 111) completed 7 tasks designed to measure LE, 5 tests of cognitive ability, and 2 personality measures. Scores on some behavioral LE tasks were moderately intercorrelated but were generally not correlated with subjective and physiological measures of LE, suggesting that these tasks may not be tapping into the same underlying construct. LE measures differed in their sensitivity to changes in signal-to-noise ratio and the extent to which they correlated with cognitive and personality variables. Given that LE measures do not show consistent, strong intercorrelations and differ in their relationships with cognitive and personality predictors, these findings suggest caution in generalizing across studies that use different measures of LE. The results also indicate that people with greater cognitive ability appear to use their resources more efficiently, thereby diminishing the detrimental effects associated with increased background noise during language processing.

An Atmospheric General Circulation Model with Chemistry for the CRAY T3E: Design, Performance Optimization and Coupling to an Ocean Model

NASA Technical Reports Server (NTRS)

Farrara, John D.; Drummond, Leroy A.; Mechoso, Carlos R.; Spahr, Joseph A.

1998-01-01

The design, implementation and performance optimization on the CRAY T3E of an atmospheric general circulation model (AGCM) which includes the transport of, and chemical reactions among, an arbitrary number of constituents is reviewed. The parallel implementation is based on a two-dimensional (longitude and latitude) data domain decomposition. Initial optimization efforts centered on minimizing the impact of substantial static and weakly-dynamic load imbalances among processors through load redistribution schemes. Recent optimization efforts have centered on single-node optimization. Strategies employed include loop unrolling, both manually and through the compiler, the use of an optimized assembler-code library for special function calls, and restructuring of parts of the code to improve data locality. Data exchanges and synchronizations involved in coupling different data-distributed models can account for a significant fraction of the running time. Therefore, the required scattering and gathering of data must be optimized. In systems such as the T3E, there is much more aggregate bandwidth in the total system than in any particular processor. This suggests a distributed design. The design and implementation of a such distributed 'Data Broker' as a means to efficiently couple the components of our climate system model is described.

Quantifying Impact of Chromosome Copy Number on Recombination in Escherichia coli.

PubMed

Reynolds, T Steele; Gill, Ryan T

2015-07-17

The ability to precisely and efficiently recombineer synthetic DNA into organisms of interest in a quantitative manner is a key requirement in genome engineering. Even though considerable effort has gone into the characterization of recombination in Escherichia coli, there is still substantial variability in reported recombination efficiencies. We hypothesized that this observed variability could, in part, be explained by the variability in chromosome copy number as well as the location of the replication forks relative to the recombination site. During rapid growth, E. coli cells may contain several pairs of open replication forks. While recombineered forks are resolving and segregating within the population, changes in apparent recombineering efficiency should be observed. In the case of dominant phenotypes, we predicted and then experimentally confirmed that the apparent recombination efficiency declined during recovery until complete segregation of recombineered and wild-type genomes had occurred. We observed the reverse trend for recessive phenotypes. The observed changes in apparent recombination efficiency were found to be in agreement with mathematical calculations based on our proposed mechanism. We also provide a model that can be used to estimate the total segregated recombination efficiency based on an initial efficiency and growth rate. These results emphasize the importance of employing quantitative strategies in the design of genome-scale engineering efforts.

Automated segmentation and dose-volume analysis with DICOMautomaton

NASA Astrophysics Data System (ADS)

Clark, H.; Thomas, S.; Moiseenko, V.; Lee, R.; Gill, B.; Duzenli, C.; Wu, J.

2014-03-01

Purpose: Exploration of historical data for regional organ dose sensitivity is limited by the effort needed to (sub-)segment large numbers of contours. A system has been developed which can rapidly perform autonomous contour sub-segmentation and generic dose-volume computations, substantially reducing the effort required for exploratory analyses. Methods: A contour-centric approach is taken which enables lossless, reversible segmentation and dramatically reduces computation time compared with voxel-centric approaches. Segmentation can be specified on a per-contour, per-organ, or per-patient basis, and can be performed along either an embedded plane or in terms of the contour's bounds (e.g., split organ into fractional-volume/dose pieces along any 3D unit vector). More complex segmentation techniques are available. Anonymized data from 60 head-and-neck cancer patients were used to compare dose-volume computations with Varian's EclipseTM (Varian Medical Systems, Inc.). Results: Mean doses and Dose-volume-histograms computed agree strongly with Varian's EclipseTM. Contours which have been segmented can be injected back into patient data permanently and in a Digital Imaging and Communication in Medicine (DICOM)-conforming manner. Lossless segmentation persists across such injection, and remains fully reversible. Conclusions: DICOMautomaton allows researchers to rapidly, accurately, and autonomously segment large amounts of data into intricate structures suitable for analyses of regional organ dose sensitivity.

DEVELOPING NEW TOOLS FOR POLICY ANALYSIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donovan, Richard L.; Schwartz, Michael J.; Selby, Kevin B.

2010-08-11

For the past three years, the Office of Security Policy has been aggressively pursuing substantial improvements in the U. S. Department of Energy (DOE) regulations and directives related to safeguards and security (S&S). An initial effort focused on areas where specific improvements could be made. This revision was completed during 2009 with the publication of a number of revised manuals. Developing these revisions involved more than 100 experts in the various disciplines involved, yet the changes made were only those that could be identified and agreed upon based largely on expert opinion. The next phase of changes will be moremore » analytically based. A thorough review of the entire (S&S) directives set will be conducted using software tools to analyze the present directives with a view toward 1) identifying areas of positive synergism among topical areas, 2) identifying areas of unnecessary duplication within and among topical areas, and 3) identifying requirements that are less than effective in achieving the intended protection goals. This paper will describe the software tools available and in development that will be used in this effort. Some examples of the output of the tools will be included, as will a short discussion of the follow-on analysis that will be performed when these outputs are available to policy analysts.« less

On implementing maximum economic yield in commercial fisheries

PubMed Central

Dichmont, C. M.; Pascoe, S.; Kompas, T.; Punt, A. E.; Deng, R.

2009-01-01

Economists have long argued that a fishery that maximizes its economic potential usually will also satisfy its conservation objectives. Recently, maximum economic yield (MEY) has been identified as a primary management objective for Australian fisheries and is under consideration elsewhere. However, first attempts at estimating MEY as an actual management target for a real fishery (rather than a conceptual or theoretical exercise) have highlighted some substantial complexities generally unconsidered by fisheries economists. Here, we highlight some of the main issues encountered in our experience and their implications for estimating and transitioning to MEY. Using a bioeconomic model of an Australian fishery for which MEY is the management target, we note that unconstrained optimization may result in effort trajectories that would not be acceptable to industry or managers. Different assumptions regarding appropriate constraints result in different outcomes, each of which may be considered a valid MEY. Similarly, alternative treatments of prices and costs may result in differing estimates of MEY and their associated effort trajectories. To develop an implementable management strategy in an adaptive management framework, a set of assumptions must be agreed among scientists, economists, and industry and managers, indicating that operationalizing MEY is not simply a matter of estimating the numbers but requires strong industry commitment and involvement. PMID:20018676

RFID sensor-tags feeding a context-aware rule-based healthcare monitoring system.

PubMed

Catarinucci, Luca; Colella, Riccardo; Esposito, Alessandra; Tarricone, Luciano; Zappatore, Marco

2012-12-01

Along with the growing of the aging population and the necessity of efficient wellness systems, there is a mounting demand for new technological solutions able to support remote and proactive healthcare. An answer to this need could be provided by the joint use of the emerging Radio Frequency Identification (RFID) technologies and advanced software choices. This paper presents a proposal for a context-aware infrastructure for ubiquitous and pervasive monitoring of heterogeneous healthcare-related scenarios, fed by RFID-based wireless sensors nodes. The software framework is based on a general purpose architecture exploiting three key implementation choices: ontology representation, multi-agent paradigm and rule-based logic. From the hardware point of view, the sensing and gathering of context-data is demanded to a new Enhanced RFID Sensor-Tag. This new device, de facto, makes possible the easy integration between RFID and generic sensors, guaranteeing flexibility and preserving the benefits in terms of simplicity of use and low cost of UHF RFID technology. The system is very efficient and versatile and its customization to new scenarios requires a very reduced effort, substantially limited to the update/extension of the ontology codification. Its effectiveness is demonstrated by reporting both customization effort and performance results obtained from validation in two different healthcare monitoring contexts.

Automatic information extraction from unstructured mammography reports using distributed semantics.

PubMed

Gupta, Anupama; Banerjee, Imon; Rubin, Daniel L

2018-02-01

To date, the methods developed for automated extraction of information from radiology reports are mainly rule-based or dictionary-based, and, therefore, require substantial manual effort to build these systems. Recent efforts to develop automated systems for entity detection have been undertaken, but little work has been done to automatically extract relations and their associated named entities in narrative radiology reports that have comparable accuracy to rule-based methods. Our goal is to extract relations in a unsupervised way from radiology reports without specifying prior domain knowledge. We propose a hybrid approach for information extraction that combines dependency-based parse tree with distributed semantics for generating structured information frames about particular findings/abnormalities from the free-text mammography reports. The proposed IE system obtains a F 1 -score of 0.94 in terms of completeness of the content in the information frames, which outperforms a state-of-the-art rule-based system in this domain by a significant margin. The proposed system can be leveraged in a variety of applications, such as decision support and information retrieval, and may also easily scale to other radiology domains, since there is no need to tune the system with hand-crafted information extraction rules. Copyright © 2018 Elsevier Inc. All rights reserved.

Millennium Development Goal 5 and adolescents: looking back, moving forward

PubMed Central

Vogel, Joshua P; Pileggi-Castro, Cynthia; Chandra-Mouli, Venkatraman; Pileggi, Vicky Nogueira; Souza, João Paulo; Chou, Doris; Say, Lale

2015-01-01

Since the Millennium Declaration in 2000, unprecedented progress has been made in the reduction of global maternal mortality. Millennium Development Goal 5 (MDG 5; improving maternal health) includes two primary targets, 5A and 5B. Target 5A aimed for a 75% reduction in the global maternal mortality ratio (MMR), and 5B aimed to achieve universal access to reproductive health. Globally, maternal mortality since 1990 has nearly halved and access to reproductive health services in developing countries has substantially improved. In setting goals and targets for the post-MDG era, the global maternal health community has recognised that ultimate goal of ending preventable maternal mortality is now within reach. The new target of a global MMR of <70 deaths per 100 000 live births by 2030 is ambitious, yet achievable and to reach this target a significantly increased effort to promote and ensure universal, equitable access to reproductive, maternal and newborn services for all women and adolescents will be required. In this article, as we reflect on patterns, trends and determinants of maternal mortality, morbidity and other key MDG5 indicators among adolescents, we aim to highlight the importance of promoting and protecting the sexual and reproductive health and rights of adolescents as part of renewed global efforts to end preventable maternal mortality. PMID:25613967

Emotions and stress increase respiratory resistance in asthma.

PubMed

Ritz, T; Steptoe, A; DeWilde, S; Costa, M

2000-01-01

Clinical reports suggest that various emotions and types of stress can precipitate asthmatic symptoms, but there is little experimental evidence to substantiate this claim. We studied the impact of different emotional states and stress on respiratory resistance in asthmatic and nonasthmatic individuals. Participants (24 asthmatic and 24 nonasthmatic patients) viewed short film sequences selected to induce anxiety, anger, depression, elation, happiness, contentment, or a neutral affective state and completed two stressful tasks, mental arithmetic to induce active coping efforts and viewing of medical slides to induce passive coping efforts. Oscillatory resistance, heart rate, blood pressure, baroreflex sensitivity, skin conductance level, respiration rate and volume, and self-reported affective state were measured throughout the session. Uniform increases in oscillatory resistance were found in all emotional states compared with the neutral state and during mental arithmetic in both groups. Asthmatic patients showed stronger reactions to the medical slides than healthy control subjects, with significant increases in oscillatory resistance, blood pressure, skin conductance level, and minute volume, as well as higher levels of self-reported depression, arousal, and shortness of breath. Changes in oscillatory resistance were inconsistently correlated with other physiological indices. Various emotional states and stress increase oscillatory resistance largely independently of concurrent increases in autonomic or ventilatory activity. The particular sensitivity of asthmatics to passive coping demand requires additional research.

A Collaborative Effort to Assess Environmental Health in ...

EPA Pesticide Factsheets

The Region 3 “Making a Visible Difference in Communities” (MVD) initiative for Southeast Newport News, VA has taken a community-centric, place-based approach to identifying and delivering service to the area’s residents and the city as a whole. Beginning with a CARE (Community Action for a Renewed Environment) Level 1 cooperative agreement (a grant with substantial government involvement and required outputs) in 2011, Region 3 funding helped to establish the Southeast CARE Coalition (“the Coalition”), and quickly formed a bond with the organization. Two years later, Region 3, the US EPA Office of Research and Development (ORD) and the Coalition embarked on a scientific, socio-demographic Regional Sustainable Environmental Science (RESES) research project to assess local pollutant sources and their potential impacts to the community. These efforts helped EPA select Newport News as an MVD community, resulting in an expanded partnership that now includes the City of Newport News. Through this association and the MVD designation, the partners have identified and prioritized environmental and other concerns (e.g., improving air and water quality, adapting to extreme weather, promoting equitable development, improving transportation). Newport News has recently held workshops and training on topics such as environmental health, asthma, weather events, and equitable development, and continues to improve the community’s health, its knowledge of the relevant e

Neural Substrates Underlying Effort, Time, and Risk-Based Decision Making in Motivated Behavior

PubMed Central

Bailey, Matthew R.; Simpson, Eleanor H.; Balsam, Peter D

2016-01-01

All mobile organisms rely on adaptive motivated behavior to overcome the challenges of living in an environment in which essential resources may be limited. A variety of influences ranging from an organism’s environment, experiential history, and physiological state all influence a cost-benefit analysis which allows motivation to energize behavior and direct it toward specific goals. Here we review the substantial amount of research aimed at discovering the interconnected neural circuits which allow organisms to carry-out the cost-benefit computations which allow them to behave in adaptive ways. We specifically focus on how the brain deals with different types of costs, including effort requirements, delays to reward and payoff riskiness. An examination of this broad literature highlights the importance of the extended neural circuits which enable organisms to make decisions about these different types of costs. This involves Cortical Structures, including the Anterior Cingulate Cortex (ACC), the Orbital Frontal Cortex (OFC), the Infralimbic Cortex (IL), and prelimbic Cortex (PL), as well as the Baso-Lateral Amygdala (BLA), the Nucleus Accumbens (Nacc), the Ventral Pallidal (VP), the Sub Thalamic Nucleus (STN) among others. Some regions are involved in multiple aspects of cost-benefit computations while the involvement of other regions is restricted to information relating to specific types of costs. PMID:27427327

Neural substrates underlying effort, time, and risk-based decision making in motivated behavior.

PubMed

Bailey, Matthew R; Simpson, Eleanor H; Balsam, Peter D

2016-09-01

All mobile organisms rely on adaptive motivated behavior to overcome the challenges of living in an environment in which essential resources may be limited. A variety of influences ranging from an organism's environment, experiential history, and physiological state all influence a cost-benefit analysis which allows motivation to energize behavior and direct it toward specific goals. Here we review the substantial amount of research aimed at discovering the interconnected neural circuits which allow organisms to carry-out the cost-benefit computations which allow them to behave in adaptive ways. We specifically focus on how the brain deals with different types of costs, including effort requirements, delays to reward and payoff riskiness. An examination of this broad literature highlights the importance of the extended neural circuits which enable organisms to make decisions about these different types of costs. This involves Cortical Structures, including the Anterior Cingulate Cortex (ACC), the Orbital Frontal Cortex (OFC), the Infralimbic Cortex (IL), and prelimbic Cortex (PL), as well as the Baso-Lateral Amygdala (BLA), the Nucleus Accumbens (NAcc), the Ventral Pallidal (VP), the Sub Thalamic Nucleus (STN) among others. Some regions are involved in multiple aspects of cost-benefit computations while the involvement of other regions is restricted to information relating to specific types of costs. Copyright © 2016 Elsevier Inc. All rights reserved.

The impact of IRCA on the job opportunities and earnings of Mexican-American and Hispanic-American workers.

PubMed

Davila, A; Pagan, J A; Viladrich Grau, M

1998-01-01

The 1986 Immigration Reform and Control Act (IRCA) introduced substantial civil and/or criminal penalties to employers who hire illegal workers, with the main goal of reducing the demand for undocumented labor. However, in the interest of addressing certain concerns about the law, the Immigration Act of 1990 was passed to require various branches of the federal government to intensify efforts to disseminate the antidiscrimination provisions of IRCA. The authors studied the earnings gap between Mexican, Hispanic, and non-Hispanic white male workers which resulted from changes in both the wage structure and immigration laws of the 1980s. It appears that Mexican and Hispanic workers were adversely affected by the changes. The analysis of data from the 1980 and 1990 1% Public Use Microdata Samples determined that Mexican and Hispanic labor were adversely affected by the increase in the returns to skills during the 1980s given their relatively lower levels of educational attainment and labor market experience. At-risk workers increased their work effort and level of productivity to reduce the effects of legislation-induced employment losses. Data were also used from the National Longitudinal Survey of Youth and the Equal Employment Opportunity Commission for the period 1983-92.

Comparative analysis of alternative co-production approaches to conservation science in Alaska

NASA Astrophysics Data System (ADS)

Trammell, E. J.

2017-12-01

Co-production has been suggested as an important tool for reducing the gap between science and management. Although co-production can require substantial investments in time and relationship building, there are a range of possible approaches that can be utilized that honor the focus and intent of co-production. I present here a comparison of three efforts that range from relatively simple, to complex and exhaustive, that illustrate diverse approaches to co-production of conservation science in Alaska. The first example highlights a workshop-based approach to identify long-term environmental monitoring needs in Alaska, while the second example describes stakeholder-driven scenarios that identified stressors to salmon in southcentral Alaska. The third example describes a 2-year cooperative agreement to develop management questions as part of a rapid ecoregional assessment in central Alaska. Results suggest that careful stakeholder selection is essential to successful co-production. Additionally, all three examples highlight the potential disconnect between management questions and specific management decisions, even when working directly with resource managers. As the focus of the Alaska Climate Science Center will be on co-production of climate science over the next 5 years, I conclude with some key pathways forward for successful co-production efforts in the future.

Patterns in artisanal coral reef fisheries revealed through local monitoring efforts

PubMed Central

Teneva, Lida T.; Ogawa, Tom; Friedlander, Alan M.

2017-01-01

Sustainable fisheries management is key to restoring and maintaining ecological function and benefits to people, but it requires accurate information about patterns of resource use, particularly fishing pressure. In most coral reef fisheries and other data-poor contexts, obtaining such information is challenging and remains an impediment to effective management. We developed the most comprehensive regional view of shore-based fishing effort and catch published to date, to show detailed fishing patterns from across the main Hawaiian Islands (MHI). We reveal these regional patterns through fisher “creel” surveys conducted by local communities, state agencies, academics, and/or environmental organizations, at 18 sites, comprising >10,000 h of monitoring across a range of habitats and human influences throughout the MHI. All creel surveys included in this study except for one were previously published in some form (peer-reviewed articles or gray literature reports). Here, we synthesize these studies to document spatial patterns in nearshore fisheries catch, effort, catch rates (i.e., catch-per-unit-effort (CPUE)), and catch disposition (i.e., use of fish after catch is landed). This effort provides for a description of general regional patterns based on these location-specific studies. Line fishing was by far the dominant gear type employed. The most efficient gear (i.e., highest CPUE) was spear (0.64 kg h−1), followed closely by net (0.61 kg h−1), with CPUE for line (0.16 kg h−1) substantially lower than the other two methods. Creel surveys also documented illegal fishing activity across the studied locations, although these activities were not consistent across sites. Overall, most of the catch was not sold, but rather retained for home consumption or given away to extended family, which suggests that cultural practices and food security may be stronger drivers of fishing effort than commercial exploitation for coral reef fisheries in Hawai‘i. Increased monitoring of spatial patterns in nearshore fisheries can inform targeted management, and can help communities develop a more informed understanding of the drivers of marine resource harvest and the state of the resources, in order to maintain these fisheries for food security, cultural practices, and ecological value. PMID:29226033

Aflatoxins: mechanisms of inhibition by antagonistic plants and microorganisms

USDA-ARS?s Scientific Manuscript database

Aflatoxins are a family of toxic fungal secondary metabolites. The rapid expansion in our knowledge about inhibition of aflatoxin biosynthesis by compounds from plants and microorganisms has enabled us to utilize them as potential biocontrol agents. Substantial efforts have been devoted to identify ...

Coast Guard : challenges for addressing budget constraints : report to congressional requesters

DOT National Transportation Integrated Search

1997-05-01

Deficit reduction efforts will create substantial pressure on the Coast : Guards budget. By fiscal year 2002, the Coast Guard is projected to have a : gap of as much as a $493 million between OMBs budget target and the : estimated cost of maint...

5 CFR 630.1208 - Protection of employment and benefits.

Code of Federal Regulations, 2010 CFR

2010-01-01

... equivalent position with equivalent benefits, pay, status, and other terms and conditions of employment. (b) For the purpose of applying paragraph (a)(2) of this section, an equivalent position must be in the... duties and responsibilities, which must entail substantially equivalent skill, effort, responsibility...

5 CFR 630.1208 - Protection of employment and benefits.

Code of Federal Regulations, 2011 CFR

2011-01-01

... equivalent position with equivalent benefits, pay, status, and other terms and conditions of employment. (b) For the purpose of applying paragraph (a)(2) of this section, an equivalent position must be in the... duties and responsibilities, which must entail substantially equivalent skill, effort, responsibility...

5 CFR 630.1210 - Protection of employment and benefits.

Code of Federal Regulations, 2013 CFR

2013-01-01

... equivalent position with equivalent benefits, pay, status, and other terms and conditions of employment. (b) For the purpose of applying paragraph (a)(2) of this section, an equivalent position must be in the... duties and responsibilities, which must entail substantially equivalent skill, effort, responsibility...

Genetics and Genomics of Coronary Artery Disease.

PubMed

Pjanic, Milos; Miller, Clint L; Wirka, Robert; Kim, Juyong B; DiRenzo, Daniel M; Quertermous, Thomas

2016-10-01

Coronary artery disease (or coronary heart disease), is the leading cause of mortality in many of the developing as well as the developed countries of the world. Cholesterol-enriched plaques in the heart's blood vessels combined with inflammation lead to the lesion expansion, narrowing of blood vessels, reduced blood flow, and may subsequently cause lesion rupture and a heart attack. Even though several environmental risk factors have been established, such as high LDL-cholesterol, diabetes, and high blood pressure, the underlying genetic composition may substantially modify the disease risk; hence, genome composition and gene-environment interactions may be critical for disease progression. Ongoing scientific efforts have seen substantial advancements related to the fields of genetics and genomics, with the major breakthroughs yet to come. As genomics is the most rapidly advancing field in the life sciences, it is important to present a comprehensive overview of current efforts. Here, we present a summary of various genetic and genomics assays and approaches applied to coronary artery disease research.

Whatever the cost? Information integration in memory-based inferences depends on cognitive effort.

PubMed

Hilbig, Benjamin E; Michalkiewicz, Martha; Castela, Marta; Pohl, Rüdiger F; Erdfelder, Edgar

2015-05-01

One of the most prominent models of probabilistic inferences from memory is the simple recognition heuristic (RH). The RH theory assumes that judgments are based on recognition in isolation, such that other information is ignored. However, some prior research has shown that available knowledge is not generally ignored. In line with the notion of adaptive strategy selection--and, thus, a trade-off between accuracy and effort--we hypothesized that information integration crucially depends on how easily accessible information beyond recognition is, how much confidence decision makers have in this information, and how (cognitively) costly it is to acquire it. In three experiments, we thus manipulated (a) the availability of information beyond recognition, (b) the subjective usefulness of this information, and (c) the cognitive costs associated with acquiring this information. In line with the predictions, we found that RH use decreased substantially, the more easily and confidently information beyond recognition could be integrated, and increased substantially with increasing cognitive costs.

Incorporation of Fixed Installation Costs into Optimization of Groundwater Remediation with a New Efficient Surrogate Nonlinear Mixed Integer Optimization Algorithm

NASA Astrophysics Data System (ADS)

Shoemaker, Christine; Wan, Ying

2016-04-01

Optimization of nonlinear water resources management issues which have a mixture of fixed (e.g. construction cost for a well) and variable (e.g. cost per gallon of water pumped) costs has been not well addressed because prior algorithms for the resulting nonlinear mixed integer problems have required many groundwater simulations (with different configurations of decision variable), especially when the solution space is multimodal. In particular heuristic methods like genetic algorithms have often been used in the water resources area, but they require so many groundwater simulations that only small systems have been solved. Hence there is a need to have a method that reduces the number of expensive groundwater simulations. A recently published algorithm for nonlinear mixed integer programming using surrogates was shown in this study to greatly reduce the computational effort for obtaining accurate answers to problems involving fixed costs for well construction as well as variable costs for pumping because of a substantial reduction in the number of groundwater simulations required to obtain an accurate answer. Results are presented for a US EPA hazardous waste site. The nonlinear mixed integer surrogate algorithm is general and can be used on other problems arising in hydrology with open source codes in Matlab and python ("pySOT" in Bitbucket).

Contrasting diversity of testate amoebae communities in Sphagnum and brown-moss dominated patches in relation to shell counts.

PubMed

Lizoňová, Zuzana; Horsák, Michal

2017-04-01

Ecological studies of peatland testate amoebae are generally based on totals of 150 individuals per sample. However, the suitability of this standard has never been assessed for alkaline habitats such as spring fens. We explored the differences in testate amoeba diversity between Sphagnum and brown-moss microhabitats at a mire site with a highly diversified moss layer which reflects the small-scale heterogeneity in groundwater chemistry. Relationships between sampling efficiency and sample completeness were explored using individual-based species accumulation curves and the effort required to gain an extra species was assessed. Testate amoeba diversity differed substantially between microhabitats, with brown mosses hosting on average twice as many species and requiring greater shell totals to reach comparable sample analysis efficiency as for Sphagnum. Thus, for samples from alkaline conditions an increase in shell totals would be required and even an overall doubling up to 300 individuals might be considered for reliable community description. Our small-scale data are likely not robust enough to provide an ultimate solution for the optimization of shell totals. However, the results proved that testate amoebae communities from acidic and alkaline environments differ sharply in both species richness and composition and they might call for different methodological approaches. Copyright © 2017 Elsevier GmbH. All rights reserved.

An airline study of advanced technology requirements for advanced high speed commercial engines. 3: Propulsion system requirements

NASA Technical Reports Server (NTRS)

Sallee, G. P.

1973-01-01

The advanced technology requirements for an advanced high speed commercial transport engine are presented. The results of the phase 3 effort cover the requirements and objectives for future aircraft propulsion systems. These requirements reflect the results of the Task 1 and 2 efforts and serve as a baseline for future evaluations, specification development efforts, contract/purchase agreements, and operational plans for future subsonic commercial engines. This report is divided into five major sections: (1) management objectives for commercial propulsion systems, (2) performance requirements for commercial transport propulsion systems, (3) design criteria for future transport engines, (4) design requirements for powerplant packages, and (5) testing.

The harmonization of the regulation of blood products: a European perspective.

PubMed

Seitz, R; Heiden, M; Nübling, C M; Unger, G; Löwer, J

2008-05-01

The development of blood products as medicines initially took place on the national level in various countries, which resulted in considerable diversity of mechanisms and stringency of regulatory oversight. The scenario changed dramatically with the catastrophic experience that severe virus infections had been transmitted by blood products world-wide. Blood products, which had been regulated differently in the member states, became subject to the European pharmaceutical legislation in 1989. A specialized directive regulating the blood transfusion sector and the collection of plasma for fractionation was enacted in 2002. The European Community, particularly the Commission and the European Medicines Agency, is continuously refining the requirements, providing detailed technical and scientific guidance. In addition, institutions of the Council of Europe play an important role in the transfusion sector, the elaboration of the European Pharmacopoeia prescriptions, and the co-ordination of Official Medicines Control Laboratory or Laboratories batch release. However, further and sustained efforts towards international harmonization are needed. There are already important mechanisms in place, such as the International Conference on Harmonization initiative, which is producing internationally recognized guidelines on central issues. Another important achievement is the common technical document format, which enables the use of uniform applications for marketing authorization. However, there is still room for progress, for example, questions regarding regulatory requirements for licensing of in vitro diagnostic devices, or mutual recognition of inspections. The World Health Organization continues to play an important role in harmonization, both substantially by the production of high-level guidance documents or the establishment of physical international standard preparations, and in a more general sense by providing a platform for international collaboration. A very important aspect is the transparency of the creation and refinement of regulatory requirements. It is currently the rule that draft legal texts, monographs and guidelines are published for a consultation period before adoption. Effort and attention are required to keep track of the developments. However, in the era of modern electronic communication tools, the necessary information can be found on websites and comments can easily be submitted. Networking and exchange of information will continue to be crucial for development and maintenance of sound and balanced regulatory requirements.

Pre-Launch Risk Reduction Activities Conducted at KSC for the International Space Station

NASA Technical Reports Server (NTRS)

Kirkpatrick, Paul

2011-01-01

In the development of any large scale space-based multi-piece assembly effort, planning must include provisions for testing and verification; not only of the individual pieces but also of the pieces together. Without such testing on the ground, the risk to cost, schedule and technical performance increases substantially. This paper will review the efforts undertaken by the International Space Station (ISS), including the International Partners, during the pre-launch phase, primarily at KSC, to reduce the risks associated with the on-orbit assembly and operation of the ISS.

Experience of a Medicaid nursing home entry cohort

PubMed Central

Ray, Wayne A.; Federspiel, Charles F.; Baugh, David K.; Dodds, Suzanne

1989-01-01

Long-term care cost-containment policies have focused on reducing the numbers of persons entering nursing homes. To provide insight and background for such efforts, the authors studied the experience of Medicaid nursing home entry cohorts in three individual States. They found substantial interstate variation in rates of nursing home entry and subsequent patterns of discharge, suggesting the operation of fundamentally different policies for provision of Medicaid nursing home services. Analysis of the cost effectiveness and quality of care implications of these policies may provide guidance for future cost-containment efforts. PMID:10313279

The Efficacy of Air Pollution Control Efforts: Evidence from AURA

NASA Technical Reports Server (NTRS)

Dickerson, Russell R.; Canty, Tim; Duncan, Bryan N.; Hao, He; Krotkov, Nickolay A.; Salawitch, Ross J.; Stehr, Jeffrey W.; Vinnikov, Konstatin

2014-01-01

Observations of NO2, SO2, and H2CO from OMI on AURA provide an excellent record of pollutant concentrations for the past decade. Abatement strategies to control criteria pollutants including ozone and fine particulate matter (PM2.5) have met with varying degrees of success. Sulfur controls had a profound impact on local SO2 concentrations and a measurable impact on PM2.5. Although substantial effort has gone into VOC control, ozone in the eastern US has responded dramatically to NOx emissions controls.

Vision-based body tracking: turning Kinect into a clinical tool.

PubMed

Morrison, Cecily; Culmer, Peter; Mentis, Helena; Pincus, Tamar

2016-08-01

Vision-based body tracking technologies, originally developed for the consumer gaming market, are being repurposed to form the core of a range of innovative healthcare applications in the clinical assessment and rehabilitation of movement ability. Vision-based body tracking has substantial potential, but there are technical limitations. We use our "stories from the field" to articulate the challenges and offer examples of how these can be overcome. We illustrate that: (i) substantial effort is needed to determine the measures and feedback vision-based body tracking should provide, accounting for the practicalities of the technology (e.g. range) as well as new environments (e.g. home). (ii) Practical considerations are important when planning data capture so that data is analysable, whether finding ways to support a patient or ensuring everyone does the exercise in the same manner. (iii) Home is a place of opportunity for vision-based body tracking, but what we do now in the clinic (e.g. balance tests) or in the home (e.g. play games) will require modifications to achieve capturable, clinically relevant measures. This article articulates how vision-based body tracking works and when it does not to continue to inspire our clinical colleagues to imagine new applications. Implications for Rehabilitation Vision-based body tracking has quickly been repurposed to form the core of innovative healthcare applications in clinical assessment and rehabilitation, but there are clinical as well as practical challenges to make such systems a reality. Substantial effort needs to go into determining what types of measures and feedback vision-based body tracking should provide. This needs to account for the practicalities of the technology (e.g. range) as well as the opportunities of new environments (e.g. the home). Practical considerations need to be accounted for when planning capture in a particular environment so that data is analysable, whether it be finding a chair substitute, ways to support a patient or ensuring everyone does the exercise in the same manner. The home is a place of opportunity with vision-based body tracking, but it would be naïve to think that we can do what we do now in the clinic (e.g. balance tests) or in the home (e.g. play games), without appropriate modifications to what constitutes a practically capturable, clinically relevant measure.

VRLA automotive batteries for stop&go and dual battery systems

NASA Astrophysics Data System (ADS)

May, G. J.; Calasanzio, D.; Aliberti, R.

The electrical power requirements for vehicles are continuing to increase and evolve. A substantial amount of effort has been directed towards the development of 36/42 V systems as a route to higher power with reduced current levels but high implementation costs have resulted in the introduction of these systems becoming deferred. In the interim, however, alternator power outputs at 14 V are being increased substantially and at the same time the requirements for batteries are becoming more intensive. In particular, stop&go systems and wire-based vehicle systems are resulting in new demands. For stop&go, the engine is stopped each time the vehicle comes to rest and is restarted when the accelerator is pressed again. This results in an onerous duty cycle with many shallow discharge cycles. Flooded lead-acid batteries cannot meet this duty cycle and valve-regulated lead-acid (VRLA) batteries are needed to meet the demands that are applied. For wire-based systems, such as brake-by-wire or steer-by-wire, electrical power has become more critical and although the alternator and battery provide double redundancy, triple redundancy with a small reserve battery is specified. In this case, a small VRLA battery can be used and is optimised for standby service rather than for repeated discharges. The background to these applications is considered and test results under simulated operating conditions are discussed. Good performance can be obtained in batteries adapted for both applications. Battery management is also critical for both applications: in stop&go service, the state-of-charge (SOC) and state-of-health (SOH) need to be monitored to ensure that the vehicle can be restarted; for reserve or back-up batteries, the SOC and SOH are monitored to verify that the battery is always capable of carrying out the duty cycle if required. Practical methods of battery condition monitoring will be described.

The cost of model reference adaptive control - Analysis, experiments, and optimization

NASA Technical Reports Server (NTRS)

Messer, R. S.; Haftka, R. T.; Cudney, H. H.

1993-01-01

In this paper the performance of Model Reference Adaptive Control (MRAC) is studied in numerical simulations and verified experimentally with the objective of understanding how differences between the plant and the reference model affect the control effort. MRAC is applied analytically and experimentally to a single degree of freedom system and analytically to a MIMO system with controlled differences between the model and the plant. It is shown that the control effort is sensitive to differences between the plant and the reference model. The effects of increased damping in the reference model are considered, and it is shown that requiring the controller to provide increased damping actually decreases the required control effort when differences between the plant and reference model exist. This result is useful because one of the first attempts to counteract the increased control effort due to differences between the plant and reference model might be to require less damping, however, this would actually increase the control effort. Optimization of weighting matrices is shown to help reduce the increase in required control effort. However, it was found that eventually the optimization resulted in a design that required an extremely high sampling rate for successful realization.

45 CFR 95.635 - Disallowance of Federal financial participation for automated systems that fail to comply...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Disallowance of Federal financial participation for automated systems that fail to comply substantially with requirements. 95.635 Section 95.635... participation for automated systems that fail to comply substantially with requirements. (a) Federal financial...

45 CFR 95.635 - Disallowance of Federal financial participation for automated systems that fail to comply...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Disallowance of Federal financial participation for automated systems that fail to comply substantially with requirements. 95.635 Section 95.635... participation for automated systems that fail to comply substantially with requirements. (a) Federal financial...

45 CFR 95.635 - Disallowance of Federal financial participation for automated systems that fail to comply...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Disallowance of Federal financial participation for automated systems that fail to comply substantially with requirements. 95.635 Section 95.635... participation for automated systems that fail to comply substantially with requirements. (a) Federal financial...

45 CFR 95.635 - Disallowance of Federal financial participation for automated systems that fail to comply...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Disallowance of Federal financial participation for automated systems that fail to comply substantially with requirements. 95.635 Section 95.635... participation for automated systems that fail to comply substantially with requirements. (a) Federal financial...

LCIA framework and cross-cutting issues guidance within the UNEP/SETAC Life Cycle Initiative

EPA Science Inventory

Increasing needs for decision support and advances in scientific knowledge within life cycle assessment (LCA) led to substantial efforts to provide global guidance on environmental life cycle impact assessment (LCIA) indicators under the auspices of the UNEP-SETAC Life Cycle Init...

Go Figure! Using Quantitative Measures to Enhance Program and Student Success

ERIC Educational Resources Information Center

Frost, Leanne H.; Braun, Gwendolyn K.

2006-01-01

Using quantitative assessment, Montana State University-Billings substantially improved and expanded its developmental education program and learning center during the past five years. Student-centered questions drove the research efforts. By gathering, analyzing and sharing hard data, the department identified unmet student needs, discovered…

Student Engagement in Inclusive Classrooms

ERIC Educational Resources Information Center

Rangvid, Beatrice Schindler

2018-01-01

Using large scale survey data, I document substantial differences in behavioural engagement (defined as involvement in academic and social activities, cooperative participation in learning, and motivation and effort) and emotional engagement levels (defined as a sense of belonging and well-being at school) between students with and without special…

Year-Long Undergraduate Research Projects

ERIC Educational Resources Information Center

Razzaghi, Mehdi

2017-01-01

Undergraduate research has become the centerpiece of many institutions of higher education's efforts to attract and recruit high school graduates. Since 1987, throughout my tenure at Bloomsburg University, I have involved over 20 students in my research. In my experience, there is clear evidence that students of mathematics substantially benefit…

General aviation accidents : the United States Air Force Aero Club solution

DOT National Transportation Integrated Search

1998-08-01

Aviation if an intrisically safe mode of travel. In 1994, the United States Air Force system of Aero Clubs put forth substantial effort to put a program in place (Fly Smart) to improve flying safety in it aircraft. This study compares the accident ra...

REDUCTION OF NITROSOBENZENES AND N-HYDROXYLANILINES BY FE (II) SPECIES: ELUCIDATION OF REACTION MECHANISM

EPA Science Inventory

There has been a substantial effort toward understanding the reduction of nitroaromatics in Fe(II)-treated ferric oxide systems, little has been done to gain insight into the factors controlling the transformation of their reaction intermediates, nitrosobenzenes and N-hydroxylani...

Assessing School Turnaround: Evidence from Ohio

ERIC Educational Resources Information Center

Player, Daniel; Katz, Veronica

2016-01-01

Policy makers have struggled to find successful approaches to address concentrated, persistent low school achievement. While NCLB and the School Improvement Grant (SIG) program have devoted significant time and attention to turnaround, very little empirical evidence substantiates whether and how these efforts work. This study employs a comparative…

Global Polio Eradication - Way Ahead.

PubMed

Bahl, Sunil; Bhatnagar, Pankaj; Sutter, Roland W; Roesel, Sigrun; Zaffran, Michel

2018-02-01

In 1988, the World Health Assembly resolved to eradicate poliomyelitis by the year 2000. Although substantial progress was achieved by 2000, global polio eradication proved elusive. In India, the goal was accomplished in 2011, and the entire South-East Asia Region was certified as polio-free in 2014. The year 2016 marks the lowest wild poliovirus type 1 case count ever, the lowest number of polio-endemic countries (Afghanistan, Nigeria and Pakistan), the maintenance of wild poliovirus type 2 eradication, and the continued absence of wild poliovirus type 3 detection since 2012. The year also marks the Global Polio Eradication Initiative (GPEI) moving into the post-cessation of Sabin type 2, after the effort of globally synchronized withdrawal of Sabin type 2 poliovirus in April 2016. Sustained efforts will be needed to ensure polio eradication is accomplished, to overcome the access and security issues, and continue to improve the quality and reach of field operations. After that, surveillance (the "eyes and ears") will move further to the center stage. Sensitive surveillance will monitor the withdrawal of all Sabin polioviruses, and with facility containment, constitute the cornerstones for eventual global certification of wild poliovirus eradication. An emergency response capacity is essential to institute timely control measures should polio still re-emerge. Simultaneously, the public health community needs to determine whether and how to apply the polio-funded infrastructure to other priorities (after the GPEI funding has stopped). Eradication is the primary goal, but securing eradication will require continued efforts, dedicated resources, and a firm commitment by the global public health community.

Organizational Influences on Interdisciplinary Interactions during Research and Design of Large-Scale Complex Engineered Systems

NASA Technical Reports Server (NTRS)

McGowan, Anna-Maria R.; Seifert, Colleen M.; Papalambros, Panos Y.

2012-01-01

The design of large-scale complex engineered systems (LaCES) such as an aircraft is inherently interdisciplinary. Multiple engineering disciplines, drawing from a team of hundreds to thousands of engineers and scientists, are woven together throughout the research, development, and systems engineering processes to realize one system. Though research and development (R&D) is typically focused in single disciplines, the interdependencies involved in LaCES require interdisciplinary R&D efforts. This study investigates the interdisciplinary interactions that take place during the R&D and early conceptual design phases in the design of LaCES. Our theoretical framework is informed by both engineering practices and social science research on complex organizations. This paper provides preliminary perspective on some of the organizational influences on interdisciplinary interactions based on organization theory (specifically sensemaking), data from a survey of LaCES experts, and the authors experience in the research and design. The analysis reveals couplings between the engineered system and the organization that creates it. Survey respondents noted the importance of interdisciplinary interactions and their significant benefit to the engineered system, such as innovation and problem mitigation. Substantial obstacles to interdisciplinarity are uncovered beyond engineering that include communication and organizational challenges. Addressing these challenges may ultimately foster greater efficiencies in the design and development of LaCES and improved system performance by assisting with the collective integration of interdependent knowledge bases early in the R&D effort. This research suggests that organizational and human dynamics heavily influence and even constrain the engineering effort for large-scale complex systems.

Bringing Big Data to the Forefront of Healthcare Delivery: The Experience of Carolinas HealthCare System.

PubMed

Dulin, Michael F; Lovin, Carol A; Wright, Jean A

2016-01-01

The use of big data to transform care delivery is rapidly becoming a reality. To deliver on the promise of value-based care, providers must know the key drivers of wellness at the patient and community levels, as well as understand resource constraints and opportunities to improve efficiency in the healthcare system itself. Data are the linchpin. By gathering the right data and finding innovative ways to glean knowledge, we can improve clinical care, advance the health of our communities, improve the lives of our patients, and operate more efficiently. At Carolinas HealthCare System-one of the nation's largest healthcare systems, with nearly 12 million patient encounters annually at more than 900 care locations-we have made substantial investments to establish a centralized data and analytics infrastructure that is transforming the way we deliver care across the continuum. Although the impetus and vision for our program have evolved over the past decade, our efforts coalesced into a strategic, centralized initiative with the launch of the Dickson Advanced Analytics (DA2) group in 2012. DA2 has yielded significant gains in our ability to use data, not only for reporting purposes and understanding our business but also for predicting outcomes and informing action.While these efforts have been successful, the path has not been easy. Effectively harnessing big data requires navigating myriad technological, cultural, operational, and other hurdles. Building a program that is feasible, effective, and sustainable takes concerted effort and a rigorous process of continuous self-evaluation and strategic adaptation.

Bringing Big Data to the Forefront of Healthcare Delivery: The Experience of Carolinas HealthCare System.

PubMed

Dulin, Michael F; Lovin, Carol A; Wright, Jean A

2017-01-01

The use of big data to transform care delivery is rapidly becoming a reality. To deliver on the promise of value-based care, providers must know the key drivers of wellness at the patient and community levels, as well as understand resource constraints and opportunities to improve efficiency in the health-care system itself. Data are the linchpin. By gathering the right data and finding innovative ways to glean knowledge, we can improve clinical care, advance the health of our communities, improve the lives of our patients, and operate more efficiently. At Carolinas HealthCare System-one of the nation's largest health-care systems, with nearly 12 million patient encounters annually at more than 900 care locations-we have made substantial investments to establish a centralized data and analytics infrastructure that is transforming the way we deliver care across the continuum. Although the impetus and vision for our program have evolved over the past decade, our efforts coalesced into a strategic, centralized initiative with the launch of the Dickson Advanced Analytics (DA) group in 2012. DA has yielded significant gains in our ability to use data, not only for reporting purposes and understanding our business but also for predicting outcomes and informing action.While these efforts have been successful, the path has not been easy. Effectively harnessing big data requires navigating myriad technological, cultural, operational, and other hurdles. Building a program that is feasible, effective, and sustainable takes concerted effort and a rigorous process of continuous self-evaluation and strategic adaptation.

Modeling the Health and Economic Burden of Hepatitis C Virus in Switzerland.

PubMed

Müllhaupt, Beat; Bruggmann, Philip; Bihl, Florian; Blach, Sarah; Lavanchy, Daniel; Razavi, Homie; Semela, David; Negro, Francesco

2015-01-01

Chronic hepatitis C virus infection is a major cause of liver disease in Switzerland and carries a significant cost burden. Currently, only conservative strategies are in place to mitigate the burden of hepatitis C in Switzerland. This study expands on previously described modeling efforts to explore the impact of: no treatment, and treatment to reduce HCC and mortality. Furthermore, the costs associated with untreated HCV were modeled. Hepatitis C disease progression and mortality were modeled. Baseline historical assumptions were collected from the literature and expert interviews and strategies were developed to show the impact of different levels of intervention (improved drug cure rates, treatment and diagnosis) until 2030. Under the historical standard of care, the number of advanced stage cases was projected to increase until 2030, at which point the annual economic burden of untreated viremic infections was projected to reach €96.8 (95% Uncertainty Interval: €36 - €232) million. Scenarios to reduce HCV liver-related mortality by 90% by 2030 required treatment of 4,190 ≥F2 or 3,200 ≥F3 patients annually by 2018 using antivirals with a 95% efficacy rate. Delaying the implementation of these scenarios by 2 or 5 years reduced the impact on mortality to 75% and 57%, respectively. With today's treatment efficacy and uptake rates, hepatitis C disease burden is expected to increase through 2030. A substantial reduction in disease burden can be achieved by means of both higher efficacy drugs and increased treatment uptake. However, these efforts cannot be undertaken without a simultaneous effort to diagnose more infections.

SU-F-E-12: Elective International Rotations in Medical Physics Residency Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, D; Mundt, A; Einck, J

Purpose: The purpose of this educational program is to motivate talented, intelligent individuals to become stakeholders in the global effort to improve access to radiotherapy. Methods: The need to improve global access to radiotherapy has been clearly established and several organizations are making substantial progress in securing funding and developing plans to achieve this worthwhile goal. The incorporation of elective international rotations in residency programs may provide one possible mechanism to promote and support this future investment. We recently incorporated an elective 1-month international rotation into our CAMPEP accredited Medical Physics residency program, with our first rotation taking place inmore » Vietnam. A unique aspect of this rotation was that it was scheduled collaboratively with our Radiation Oncology residency program such that Radiation Oncology and Medical Physics residents traveled to the same clinic at the same time. Results: We believe the international rotation substantially enhances the educational experience, providing additional benefits to residents by increasing cross-disciplinary learning and offering a shared learning experience. The combined international rotation may also increase benefit to the host institution by modeling positive multidisciplinary working relationships between Radiation Oncologists and Medical Physicists. Our first resident returned with several ideas designed to improve radiotherapy in resource-limited settings – one of which is currently being pursued in collaboration with a vendor. Conclusion: The elective international rotation provides a unique learning experience that has the potential to motivate residents to become stakeholders in the global effort to improve access to radiotherapy. What better way to prepare the next generation of Medical Physicists to meet the challenges of improving global access to radiotherapy than to provide them with training experiences that motivate them to be socially conscious and equip them with the clinical and problem solving skills required to deliver effective treatments in resource limited settings?.« less

The costs of avoiding environmental impacts from shale-gas surface infrastructure.

PubMed

Milt, Austin W; Gagnolet, Tamara D; Armsworth, Paul R

2016-12-01

Growing energy demand has increased the need to manage conflicts between energy production and the environment. As an example, shale-gas extraction requires substantial surface infrastructure, which fragments habitats, erodes soils, degrades freshwater systems, and displaces rare species. Strategic planning of shale-gas infrastructure can reduce trade-offs between economic and environmental objectives, but the specific nature of these trade-offs is not known. We estimated the cost of avoiding impacts from land-use change on forests, wetlands, rare species, and streams from shale-energy development within leaseholds. We created software for optimally siting shale-gas surface infrastructure to minimize its environmental impacts at reasonable construction cost. We visually assessed sites before infrastructure optimization to test whether such inspection could be used to predict whether impacts could be avoided at the site. On average, up to 38% of aggregate environmental impacts of infrastructure could be avoided for 20% greater development costs by spatially optimizing infrastructure. However, we found trade-offs between environmental impacts and costs among sites. In visual inspections, we often distinguished between sites that could be developed to avoid impacts at relatively low cost (29%) and those that could not (20%). Reductions in a metric of aggregate environmental impact could be largely attributed to potential displacement of rare species, sedimentation, and forest fragmentation. Planners and regulators can estimate and use heterogeneous trade-offs among development sites to create industry-wide improvements in environmental performance and do so at reasonable costs by, for example, leveraging low-cost avoidance of impacts at some sites to offset others. This could require substantial effort, but the results and software we provide can facilitate the process. © 2016 Society for Conservation Biology.

Using Commercial Digital Cameras and Structure-for-Motion Software to Map Snow Cover Depth from Small Aircraft

NASA Astrophysics Data System (ADS)

Sturm, M.; Nolan, M.; Larsen, C. F.

2014-12-01

A long-standing goal in snow hydrology has been to map snow cover in detail, either mapping snow depth or snow water equivalent (SWE) with sub-meter resolution. Airborne LiDAR and air photogrammetry have been used successfully for this purpose, but both require significant investments in equipment and substantial processing effort. Here we detail a relatively inexpensive and simple airborne photogrammetric technique that can be used to measure snow depth. The main airborne hardware consists of a consumer-grade digital camera attached to a survey-quality, dual-frequency GPS. Photogrammetric processing is done using commercially available Structure from Motion (SfM) software that does not require ground control points. Digital elevation models (DEMs) are made from snow-free acquisitions in the summer and snow-covered acquisitions in winter, and the maps are then differenced to arrive at snow thickness. We tested the accuracy and precision of snow depths measured using this system through 1) a comparison with airborne scanning LiDAR, 2) a comparison of results from two independent and slightly different photogrameteric systems, and 3) comparison to extensive on-the-ground measured snow depths. Vertical accuracy and precision are on the order of +/-30 cm and +/- 8 cm, respectively. The accuracy can be made to approach that of the precision if suitable snow-free ground control points exists and are used to co-register summer to winter DEM maps. Final snow depth accuracy from our series of tests was on the order of ±15 cm. This photogrammetric method substantially lowers the economic and expertise barriers to entry for mapping snow.

Current Developments and Challenges in the Search for a Naturally Selected Diels-Alderase

PubMed Central

Kim, Hak Joong; Ruszczycky, Mark W.; Liu, Hung-wen

2012-01-01

Only a very few examples of enzymes known to catalyze pericyclic reactions have been reported, and presently no enzyme has been demonstrated unequivocally to catalyze a Diels-Alder reaction. Nevertheless, research into secondary metabolism has led to the discovery of numerous natural products exhibiting the structural hallmarks of [4+2] cycloadditions, prompting efforts to characterize the responsible enzymatic processes. These efforts have resulted in a growing collection of enzymes believed to catalyze pericyclic [4+2] cycloaddition reactions; however, in each case the complexity of the substrates and catalytic properties of these enzymes poses significant challenges in substantiating these hypotheses. Herein we consider the principles motivating these efforts and the enzymological systems currently under investigation. PMID:22260931

Temperamental factors in remitted depression: The role of effortful control and attentional mechanisms.

PubMed

Marchetti, Igor; Shumake, Jason; Grahek, Ivan; Koster, Ernst H W

2018-08-01

Temperamental effortful control and attentional networks are increasingly viewed as important underlying processes in depression and anxiety. However, it is still unknown whether these factors facilitate depressive and anxiety symptoms in the general population and, more specifically, in remitted depressed individuals. We investigated to what extent effortful control and attentional networks (i.e., Attention Network Task) explain concurrent depressive and anxious symptoms in healthy individuals (n = 270) and remitted depressed individuals (n = 90). Both samples were highly representative of the US population. Increased effortful control predicted a substantial decrease in symptoms of both depression and anxiety in the whole sample, whereas decreased efficiency of executive attention predicted a modest increase in depressive symptoms. Remitted depressed individuals did not show less effortful control nor less efficient attentional networks than healthy individuals. Moreover, clinical status did not moderate the relationship between temperamental factors and either depressive or anxiety symptoms. Limitations include the cross-sectional nature of the study. Our study shows that temperamental effortful control represents an important transdiagnostic process for depressive and anxiety symptoms in adults. Copyright © 2018 Elsevier B.V. All rights reserved.

Expanding efforts to address Alzheimer’s disease: The Healthy Brain Initiative

PubMed Central

Anderson, Lynda A.; Egge, Robert

2015-01-01

The growing burden of Alzheimer’s disease underscores the importance of enhancing current public health efforts to address dementia. Public health organizations and entities have substantial opportunities to contribute to efforts underway and to add innovations to the field. The Alzheimer’s Association and the Centers for Disease Control and Prevention worked with a 15-member leadership committee and hundreds of stakeholders to create The Healthy Brain Initiative: The Public Health Road Map for State and National Partnerships, 2013–2018 (Road Map). The actions in the Road Map provide a foundation for the public health community to anticipate and respond to emerging innovations and developments. It will be a challenge to harness the increasingly complex nature of public- and private-sector collaborations. We must strengthen the capacity of public health agencies, leverage partnerships, and find new ways to integrate cognitive functioning into public health efforts. PMID:25088658

40 CFR 33.302 - Are there any additional contract administration requirements?

Code of Federal Regulations, 2014 CFR

2014-07-01

... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

40 CFR 33.302 - Are there any additional contract administration requirements?

Code of Federal Regulations, 2012 CFR

2012-07-01

... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

40 CFR 33.302 - Are there any additional contract administration requirements?

Code of Federal Regulations, 2013 CFR

2013-07-01

... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

40 CFR 33.302 - Are there any additional contract administration requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... faith efforts described in § 33.301 if soliciting a replacement subcontractor. (d) A recipient must require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime...

Sustainable exploitation and management of autogenic ecosystem engineers: application to oysters in Chesapeake Bay.

PubMed

Wilberg, Michael J; Wiedenmann, John R; Robinson, Jason M

2013-06-01

Autogenic ecosystem engineers are critically important parts of many marine and estuarine systems because of their substantial effect on ecosystem services. Oysters are of particular importance because of their capacity to modify coastal and estuarine habitats and the highly degraded status of their habitats worldwide. However, models to predict dynamics of ecosystem engineers have not previously included the effects of exploitation. We developed a linked population and habitat model for autogenic ecosystem engineers undergoing exploitation. We parameterized the model to represent eastern oyster (Crassostrea virginica) in upper Chesapeake Bay by selecting sets of parameter values that matched observed rates of change in abundance and habitat. We used the model to evaluate the effects of a range of management and restoration options including sustainability of historical fishing pressure, effectiveness of a newly enacted sanctuary program, and relative performance of two restoration approaches. In general, autogenic ecosystem engineers are expected to be substantially less resilient to fishing than an equivalent species that does not rely on itself for habitat. Historical fishing mortality rates in upper Chesapeake Bay for oysters were above the levels that would lead to extirpation. Reductions in fishing or closure of the fishery were projected to lead to long-term increases in abundance and habitat. For fisheries to become sustainable outside of sanctuaries, a substantial larval subsidy would be required from oysters within sanctuaries. Restoration efforts using high-relief reefs were predicted to allow recovery within a shorter period of time than low-relief reefs. Models such as ours, that allow for feedbacks between population and habitat dynamics, can be effective tools for guiding management and restoration of autogenic ecosystem engineers.

NTP comparison process

NASA Technical Reports Server (NTRS)

Corban, Robert

1993-01-01

The systems engineering process for the concept definition phase of the program involves requirements definition, system definition, and consistent concept definition. The requirements definition process involves obtaining a complete understanding of the system requirements based on customer needs, mission scenarios, and nuclear thermal propulsion (NTP) operating characteristics. A system functional analysis is performed to provide a comprehensive traceability and verification of top-level requirements down to detailed system specifications and provides significant insight into the measures of system effectiveness to be utilized in system evaluation. The second key element in the process is the definition of system concepts to meet the requirements. This part of the process involves engine system and reactor contractor teams to develop alternative NTP system concepts that can be evaluated against specific attributes, as well as a reference configuration against which to compare system benefits and merits. Quality function deployment (QFD), as an excellent tool within Total Quality Management (TQM) techniques, can provide the required structure and provide a link to the voice of the customer in establishing critical system qualities and their relationships. The third element of the process is the consistent performance comparison. The comparison process involves validating developed concept data and quantifying system merits through analysis, computer modeling, simulation, and rapid prototyping of the proposed high risk NTP subsystems. The maximum amount possible of quantitative data will be developed and/or validated to be utilized in the QFD evaluation matrix. If upon evaluation of a new concept or its associated subsystems determine to have substantial merit, those features will be incorporated into the reference configuration for subsequent system definition and comparison efforts.

3 CFR 8531 - Proclamation 8531 of May 28, 2010. National Oceans Month, 2010

Code of Federal Regulations, 2011 CFR

2011-01-01

... considerable strain from pollution, overfishing, climate change, and other human activity. Last year, I... we continue our relentless efforts to stop and contain the oil spill threatening the Gulf Coast region. The oil spill has already caused substantial damage to our coastline and its natural habitats...

Constructive Student Feedback: Online vs. Traditional Course Evaluations

ERIC Educational Resources Information Center

Donovan, Judy; Mader, Cynthia E.; Shinsky, John

2010-01-01

Substantial efforts have been made recently to compare the effectiveness of traditional course formats to alternative formats (most often, online delivery compared to traditional on-site delivery). This study examines, not the delivery format but rather the evaluation format. It compares traditional paper and pencil methods for course evaluation…

Comparative community case studies as research tools: A national effort to support local sustainability planning

EPA Science Inventory

The provisioning of aquatic ecosystem goods and services (EGS) is a key concept in USEPA Office of Research and Development research programs. This is a national issue, yet many decisions affecting EGS sustainability are made at the local level where decisions can have substanti...

Learning and Teaching Traditional Music in Cambodia: Challenges and Incentives

ERIC Educational Resources Information Center

Grant, Catherine

2017-01-01

Substantial efforts have been made since the Khmer Rouge regime to revitalize traditional Cambodian music genres. While they have met with some success, local circumstances still present many difficulties for the transmission of traditional music to the younger generations. This study explores the challenges in learning and teaching traditional…

At-Risk Students. Consider Integrated Strategies.

ERIC Educational Resources Information Center

Altieri, Dino

1991-01-01

Early intervention, substantial parent involvement, effective instruction, and staff development that empowers teachers can improve the achievement of at-risk students. The task is to combine each of these components into a coherent whole by coordinating the efforts of the school, the family, and the community into a comprehensive set of…

Is VoIP Worth It?

ERIC Educational Resources Information Center

Schaffhauser, Dian

2008-01-01

School districts have by and large had great results implementing VoIP, which has become the conduit for delivering expanded functionality, achieving greater internal control, and gaining freedom from onerous monthly phone bills. But demonstrating a financial return on what is a substantial investment can be an elusive effort. The goal of…

The College Completion Agenda: State Policy Guide. Latino Edition

ERIC Educational Resources Information Center

College Board Advocacy & Policy Center, 2011

2011-01-01

State public policy has been an important tool for improving the educational preparation and opportunity for many communities. However, without concerted statewide efforts it will continue to be difficult to substantially expand opportunities to accelerate higher education attainment and workforce preparation. Over the next 15 years, the states…

Retrospective Montioring of Ecosystem Changes Using Published Data, Lessons Learned from Egypt's Nile River Delta

EPA Science Inventory

Monitoring programs for riverine and wetland ecosystems often do not begin until some substantial shift in ecosystem structure or loss of ecosystem service has taken place. Sometimes a lack of resources or interest may impede monitoring efforts. In the case of the large brackis...

"Ratio via Machina": Three Standards of Mechanistic Explanation in Sociology

ERIC Educational Resources Information Center

Aviles, Natalie B.; Reed, Isaac Ariail

2017-01-01

Recently, sociologists have expended much effort in attempts to define social mechanisms. We intervene in these debates by proposing that sociologists in fact have a choice to make between three standards of what constitutes a good mechanistic explanation: substantial, formal, and metaphorical mechanistic explanation. All three standards are…

Factors influencing export of dissolved inorganic nitrogen by major rivers: A new seasonal, spatially explicit, global model - 2012

EPA Science Inventory

Background/Question/Methods Substantial effort has focused on understanding spatial variation in dissolved inorganic nitrogen (DIN) export to the coastal zone and specific basins have been studied in some depth. Much less is known, however, about seasonal patterns and zone and ...

Factors influencing export of dissolved inorganic nitrogen by major rivers: a new seasonal, spatially explicit, global model

EPA Science Inventory

Background/Question/Methods Substantial effort has focused on understanding spatial variation in dissolved inorganic nitrogen (DIN) export to the coastal zone and specific basins have been studied in some depth. Much less is known, however, about seasonal patterns and controls ...

Report: EPA Needs to Direct More Attention, Efforts, and Funding to Enhance Its Speciation Monitoring Program for Measuring Fine Particulate Matter

EPA Pesticide Factsheets

Report #2005-P-00004, February 7, 2005. EPA has made substantial progress in establishing a speciation monitoring network, but still faces a number of challenges in ensuring that the controls are implemented at the right sources.

Conservation of native Pacific trout diversity in Western North America

Treesearch

Brooke E. Penaluna; Alicia Abadía-Cardoso; Jason B. Dunham; Francisco J. García-Dé León; Robert E. Gresswell; Arturo Ruiz Luna; Eric B. Taylor; Bradley B. Shepard; Robert Al-Chokhachy; Clint C. Muhlfeld; Kevin R. Bestgen; Kevin Rogers; Marco A. Escalante; Ernest R. Keeley; Gabriel M. Temple; Jack E. Williams; Kathleen R. Matthews; Ron Pierce; Richard L. Mayden; Ryan P. Kovach; John Carlos Garza; Kurt D. Fausch

2016-01-01

Pacific trout Oncorhynchus spp. in western North America are strongly valued in ecological, socioeconomic, and cultural views, and have been the subject of substantial research and conservation efforts. Despite this, the understanding of their evolutionary histories, overall diversity, and challenges to their conservation is incomplete. We review...

Evaluation of a Moderate Resolution, Satellite-Based Impervious Surface Map Using an Independent, High-Resolution Validation Dataset

EPA Science Inventory

Given the relatively high cost of mapping impervious surfaces at regional scales, substantial effort is being expended in the development of moderate-resolution, satellite-based methods for estimating impervious surface area (ISA). To rigorously assess the accuracy of these data ...

Parallel and Serial Processes in Visual Search

ERIC Educational Resources Information Center

Thornton, Thomas L.; Gilden, David L.

2007-01-01

A long-standing issue in the study of how people acquire visual information centers around the scheduling and deployment of attentional resources: Is the process serial, or is it parallel? A substantial empirical effort has been dedicated to resolving this issue. However, the results remain largely inconclusive because the methodologies that have…

7 CFR 3406.15 - Evaluation criteria for teaching proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... have a substantial impact upon and advance the quality of food and agricultural sciences higher... food and agricultural sciences? If successful, is the project likely to lead to education reform? 10... it expand upon other major efforts to improve the quality of food and agricultural sciences higher...

U.S. ports and the funding of intermodal facilities : an overview of key issues

DOT National Transportation Integrated Search

2000-03-28

The growing us eof containers to move freight has led carriers to use fewer but larger ports. In their efforts to attract and retain carriers, U.S. ports have made or are planning substantial investments in new berths, docks, and improved connections...

Thermal noise in space-charge-limited hole current in silicon

NASA Technical Reports Server (NTRS)

Shumka, A.; Golder, J.; Nicolet, M.

1972-01-01

Present theories on noise in single-carrier space-charge-limited currents in solids have not been quantitatively substantiated by experimental evidence. To obtain such experimental verification, the noise in specially fabricated silicon structures is being measured and analyzed. The first results of this verification effort are reported.

Factors influencing export of dissolved inorganic nitrogen by major rivers: A new, seasonal, spatially explicit, global model

EPA Science Inventory

Substantial effort has focused on understanding spatial variation in dissolved inorganic nitrogen (DIN) export to the coastal zone and specific basins have been studied in depth. Much less is known, however, about seasonal patterns and controls of coastal DIN delivery across larg...

Factors Contributing to Problem-Solving Performance in First-Semester Organic Chemistry

ERIC Educational Resources Information Center

Lopez, Enrique J.; Shavelson, Richard J.; Nandagopal, Kiruthiga; Szu, Evan; Penn, John

2014-01-01

Problem solving is a highly valued skill in chemistry. Courses within this discipline place a substantial emphasis on problem-solving performance and tend to weigh such performance heavily in assessments of learning. Researchers have dedicated considerable effort investigating individual factors that influence problem-solving performance. The…

THE DISADVANTAGED CHILDREN AND YOUTH OF AMERICA.

ERIC Educational Resources Information Center

OETTINGER, KATHERINE B.

PROGRESS IS BEING MADE TOWARD ERASING THE DISADVANTAGES OF THE MENTALLY RETARDED. MUCH PROGRESS HAS BEEN MADE IN RECOGNIZING THE HEALTH NEEDS OF THE RETARDED CHILD THROUGH SUBSTANTIAL LEGISLATION SPONSORED BY MANY BRANCHES OF GOVERNMENT, ACTION PROGRAMS STEMMING FROM BOTH PUBLIC AND VOLUNTARY SOURCES, AND A MOUNTING RESEARCH EFFORT. IN AN EFFORT…

Automatic Vehicle Location successful transit applications : a cross-cutting study : improving service and safety

DOT National Transportation Integrated Search

2000-08-01

Belief in the value of AVL is substantiated by statements of benefits contained earlier in this study. Even so, none of the study agencies are making full use of the voluminous amount of AVL data automatically recorded by the system. Efforts to make ...

Adolescent Dating Violence: How Should Schools Respond?

ERIC Educational Resources Information Center

Surface, Jeanne; Stader, David; Graca, Thomas; Lowe, Jerry

2012-01-01

Educational leaders have a substantial degree of control over students and generally have a tremendous influence on the decisions that they make. District administrators are already involved in comprehensive efforts to stem sexual harassment, teen violence and bullying; therefore, they may be well positioned to identify and address the problem of…

Facebook Is an Effective Strategy to Recruit Low-Income Women to Online Nutrition Education

ERIC Educational Resources Information Center

Lohse, Barbara

2013-01-01

Objective: Nutrition education research recruitment expense and effort are substantial; sample selection is crucial for intervention assessment. Effectiveness and cost of Facebook to recruit low-income women to an online nutrition program were examined, including biopsychosocial characteristics of Facebook responders. Methods: An ad appeared on…

Why Do Teachers Leave? CenterView

ERIC Educational Resources Information Center

Center for the Future of Teaching and Learning, 2007

2007-01-01

While California has made substantial progress in easing its teacher shortage and reducing the concentration of the least prepared teachers in the lowest achieving schools, the effort to strengthen schools for all students is hampered by the large number of teachers who leave the profession prematurely. Policymakers at the state and local levels…

Migratory Patterns of Wild Chinook Salmon Oncorhynchus tshawytscha Returning to a Large, Free-Flowing River Basin

PubMed Central

Eiler, John H.; Evans, Allison N.; Schreck, Carl B.

2015-01-01

Upriver movements were determined for Chinook salmon Oncorhynchus tshawytscha returning to the Yukon River, a large, virtually pristine river basin. These returns have declined dramatically since the late 1990s, and information is needed to better manage the run and facilitate conservation efforts. A total of 2,860 fish were radio tagged during 2002–2004. Most (97.5%) of the fish tracked upriver to spawning areas displayed continual upriver movements and strong fidelity to the terminal tributaries entered. Movement rates were substantially slower for fish spawning in lower river tributaries (28–40 km d-1) compared to upper basin stocks (52–62 km d-1). Three distinct migratory patterns were observed, including a gradual decline, pronounced decline, and substantial increase in movement rate as the fish moved upriver. Stocks destined for the same region exhibited similar migratory patterns. Individual fish within a stock showed substantial variation, but tended to reflect the regional pattern. Differences between consistently faster and slower fish explained 74% of the within-stock variation, whereas relative shifts in sequential movement rates between “hares” (faster fish becoming slower) and “tortoises” (slow but steady fish) explained 22% of the variation. Pulses of fish moving upriver were not cohesive. Fish tagged over a 4-day period took 16 days to pass a site 872 km upriver. Movement rates were substantially faster and the percentage of atypical movements considerably less than reported in more southerly drainages, but may reflect the pristine conditions within the Yukon River, wild origins of the fish, and discrete run timing of the returns. Movement data can provide numerous insights into the status and management of salmon returns, particularly in large river drainages with widely scattered fisheries where management actions in the lower river potentially impact harvests and escapement farther upstream. However, the substantial variation exhibited among individual fish within a stock can complicate these efforts. PMID:25919286

Migratory Patterns of Chinook Salmon Oncorhynchus tshawytscha Returning to a Large, Free-flowing River Basin

USGS Publications Warehouse

Eiler, John H.; Evans, Allison N.; Schreck, Carl B.

2015-01-01

Upriver movements were determined for Chinook salmon Oncorhynchus tshawytscha returning to the Yukon River, a large, virtually pristine river basin. These returns have declined dramatically since the late 1990s, and information is needed to better manage the run and facilitate conservation efforts. A total of 2,860 fish were radio tagged during 2002–2004. Most (97.5%) of the fish tracked upriver to spawning areas displayed continual upriver movements and strong fidelity to the terminal tributaries entered. Movement rates were substantially slower for fish spawning in lower river tributaries (28–40 km d-1) compared to upper basin stocks (52–62 km d-1). Three distinct migratory patterns were observed, including a gradual decline, pronounced decline, and substantial increase in movement rate as the fish moved upriver. Stocks destined for the same region exhibited similar migratory patterns. Individual fish within a stock showed substantial variation, but tended to reflect the regional pattern. Differences between consistently faster and slower fish explained 74% of the within-stock variation, whereas relative shifts in sequential movement rates between “hares” (faster fish becoming slower) and “tortoises” (slow but steady fish) explained 22% of the variation. Pulses of fish moving upriver were not cohesive. Fish tagged over a 4-day period took 16 days to pass a site 872 km upriver. Movement rates were substantially faster and the percentage of atypical movements considerably less than reported in more southerly drainages, but may reflect the pristine conditions within the Yukon River, wild origins of the fish, and discrete run timing of the returns. Movement data can provide numerous insights into the status and management of salmon returns, particularly in large river drainages with widely scattered fisheries where management actions in the lower river potentially impact harvests and escapement farther upstream. However, the substantial variation exhibited among individual fish within a stock can complicate these efforts.

7 CFR 1955.103 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... applies to all members of an entity. (3) Will materially and substantially participate in the operation of... substantially participate in the operation of the farm or ranch. Material and substantial participation requires...-to-day activities, such that if the individual did not provide these inputs, operation of the farm or...

7 CFR 1955.103 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... applies to all members of an entity. (3) Will materially and substantially participate in the operation of... substantially participate in the operation of the farm or ranch. Material and substantial participation requires...-to-day activities, such that if the individual did not provide these inputs, operation of the farm or...

7 CFR 1955.103 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... applies to all members of an entity. (3) Will materially and substantially participate in the operation of... substantially participate in the operation of the farm or ranch. Material and substantial participation requires...-to-day activities, such that if the individual did not provide these inputs, operation of the farm or...

7 CFR 1955.103 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... applies to all members of an entity. (3) Will materially and substantially participate in the operation of... substantially participate in the operation of the farm or ranch. Material and substantial participation requires...-to-day activities, such that if the individual did not provide these inputs, operation of the farm or...

Fiscal Year 2016 Revegetation Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nordstrom, Jenifer B.

This report summarizes the Fiscal Year (FY) 2016 Revegetation Assessment by Battelle Energy Alliance, LLC. This assessment was conducted to document revegetation efforts at Idaho National Laboratory to verify restoration of disturbed vegetation and soil at various locations occurs as required. This report provides the following information for projects at Idaho National Laboratory completed during FY 2016 that were identified during the National Environmental Policy Act review process as having the potential to disturb soils or vegetation: 1) A summary of all projects identified as having the potential to require revegetation efforts 2) A summary of site disturbance and restorationmore » efforts of each project. For FY 2016, one project required revegetation and sagebrush restoration. For other projects, implementation of best management practices minimized impacts to vegetation and revegetation efforts were not required.« less

Greater effort increases perceived value in an invertebrate.

PubMed

Czaczkes, Tomer J; Brandstetter, Birgit; di Stefano, Isabella; Heinze, Jürgen

2018-05-01

Expending effort is generally considered to be undesirable. However, both humans and vertebrates will work for a reward they could also get for free. Moreover, cues associated with high-effort rewards are preferred to low-effort associated cues. Many explanations for these counterintuitive findings have been suggested, including cognitive dissonance (self-justification) or a greater contrast in state (e.g., energy or frustration level) before and after an effort-linked reward. Here, we test whether effort expenditure also increases perceived value in ants, using both classical cue-association methods and pheromone deposition, which correlates with perceived value. In 2 separate experimental setups, we show that pheromone deposition is higher toward the reward that requires more effort: 47% more pheromone deposition was performed for rewards reached via a vertical runway (high effort) compared with ones reached via a horizontal runway (low effort), and deposition rates were 28% higher on rough (high effort) versus smooth (low effort) runways. Using traditional cue-association methods, 63% of ants trained on different surface roughness, and 70% of ants trained on different runway elevations, preferred the high-effort related cues on a Y maze. Finally, pheromone deposition to feeders requiring memorization of one path bifurcation was up to 29% higher than to an identical feeder requiring no learning. Our results suggest that effort affects value perception in ants. This effect may stem from a cognitive process, which monitors the change in a generalized hedonic state before and after reward. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

A new vision for the study of benign prostate disease: the NIDDK Prostate Research Strategic Plan.

PubMed

Mullins, Chris; Kaplan, Steven A

2009-03-01

The American population continues to enjoy a steady increase in life expectancy. A major goal for this population is to maintain and improve quality of life as it ages. For men a major source of age related health burden is benign disorders of the prostate which, despite much research, remain poorly defined and require greater advancement in prevention and treatment. Thus, there is a substantial need to develop a long-range vision to focus and promote efforts to better understand and manage benign prostate disease. In response the National Institute of Diabetes and Digestive and Kidney Diseases convened a panel of key opinion leaders including basic researchers, translational scientists, epidemiologists, and clinicians and clinical researchers to develop a comprehensive strategic plan to advance research in benign prostate disease. The overall mission statement of this effort is "To discuss, evaluate, and propose research needs and a long-range research agenda (ie a strategic plan) for NIDDK grant portfolios related to research into benign prostate disease." Implementation and practical application of this strategic plan will require a partnership of the scientific community, the Federal Government, and other public and private organizations and institutions. This focused group of research and thought leaders identified 4 major areas of key significance for future investigation: basic science, epidemiology/population based studies, translational opportunities and clinical sciences. Great opportunities are identified within these 4 areas to develop new insights, and translate findings for benign prostate diseases and related syndromes between the research laboratory and the clinical setting. The product of these efforts, the National Institute of Diabetes and Digestive and Kidney Diseases Prostate Research Strategic Plan, represents a blueprint that researchers and Federal Government can use to review where the field has been, define where the field is and, most importantly, identify where and how future research efforts should be directed. To accomplish this goal many priorities must be addressed, including the need to create more effective lines of communication among scientific disciplines to improve translation of research findings and ultimately advance patient treatment. The overall goals and missions of the National Institute of Diabetes and Digestive and Kidney Diseases Prostate Research Strategic Plan, along with key scientific recommendations and priorities for the major areas of focus, are summarized.

Validation of coupled atmosphere-fire behavior models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bossert, J.E.; Reisner, J.M.; Linn, R.R.

1998-12-31

Recent advances in numerical modeling and computer power have made it feasible to simulate the dynamical interaction and feedback between the heat and turbulence induced by wildfires and the local atmospheric wind and temperature fields. At Los Alamos National Laboratory, the authors have developed a modeling system that includes this interaction by coupling a high resolution atmospheric dynamics model, HIGRAD, with a fire behavior model, BEHAVE, to predict the spread of wildfires. The HIGRAD/BEHAVE model is run at very high resolution to properly resolve the fire/atmosphere interaction. At present, these coupled wildfire model simulations are computationally intensive. The additional complexitymore » of these models require sophisticated methods for assuring their reliability in real world applications. With this in mind, a substantial part of the research effort is directed at model validation. Several instrumented prescribed fires have been conducted with multi-agency support and participation from chaparral, marsh, and scrub environments in coastal areas of Florida and inland California. In this paper, the authors first describe the data required to initialize the components of the wildfire modeling system. Then they present results from one of the Florida fires, and discuss a strategy for further testing and improvement of coupled weather/wildfire models.« less

Cooled Ceramic Composite Panel Tested Successfully in Rocket Combustion Facility

NASA Technical Reports Server (NTRS)

Jaskowiak, Martha H.

2003-01-01

Regeneratively cooled ceramic matrix composite (CMC) structures are being considered for use along the walls of the hot-flow paths of rocket-based or turbine-based combined-cycle propulsion systems. They offer the combined benefits of substantial weight savings, higher operating temperatures, and reduced coolant requirements in comparison to components designed with traditional metals. These cooled structures, which use the fuel as the coolant, require materials that can survive aggressive thermal, mechanical, acoustic, and aerodynamic loads while acting as heat exchangers, which can improve the efficiency of the engine. A team effort between the NASA Glenn Research Center, the NASA Marshall Space Flight Center, and various industrial partners has led to the design, development, and fabrication of several types of regeneratively cooled panels. The concepts for these panels range from ultra-lightweight designs that rely only on CMC tubes for coolant containment to more maintainable designs that incorporate metal coolant containment tubes to allow for the rapid assembly or disassembly of the heat exchanger. One of the cooled panels based on an all-CMC design was successfully tested in the rocket combustion facility at Glenn. Testing of the remaining four panels is underway.

Hearing conservation practices in eight noisy industries

NASA Astrophysics Data System (ADS)

Daniell, William E.; Swan, Susan S.; Camp, Janice; Cohen, Martin; McDaniel, Mary M.; Stebbins, John; Leo, Robert

2005-04-01

This study evaluated noise exposures and hearing conservation practices at 76 companies in eight industries with high rates of workers' compensation claims for hearing loss. Nearly all companies had exposures that required a hearing conservation program, and more than half had exposures that required consideration of noise controls. The use of noise measurements and consideration of controls was low in all industries. The completeness of hearing conservation programs was strongly associated with the extent of exposure in an industry, although practices varied widely within industries. Most companies had substantial deficiencies. More than one-third did not conduct annual training, and training had shortcomings at many others. One-third had not conducted audiometry. Hearing protection was commonly underused. Reported use was highest at companies with relatively complete programs, and in industries where exposure was most prevalent and least intermittent. Many employees had difficulty estimating how often, and presumably when, their exposure was excessive. There is a need for new strategies to promote and maintain hearing conservation efforts in noisy industries. The industries with greatest margin for improvement are not the noisiest industries but those where exposure is moderate or intermittent. [Work supported by the National Institute for Occupational Safety and Health.

Isosurface Extraction in Time-Varying Fields Using a Temporal Hierarchical Index Tree

NASA Technical Reports Server (NTRS)

Shen, Han-Wei; Gerald-Yamasaki, Michael (Technical Monitor)

1998-01-01

Many high-performance isosurface extraction algorithms have been proposed in the past several years as a result of intensive research efforts. When applying these algorithms to large-scale time-varying fields, the storage overhead incurred from storing the search index often becomes overwhelming. this paper proposes an algorithm for locating isosurface cells in time-varying fields. We devise a new data structure, called Temporal Hierarchical Index Tree, which utilizes the temporal coherence that exists in a time-varying field and adoptively coalesces the cells' extreme values over time; the resulting extreme values are then used to create the isosurface cell search index. For a typical time-varying scalar data set, not only does this temporal hierarchical index tree require much less storage space, but also the amount of I/O required to access the indices from the disk at different time steps is substantially reduced. We illustrate the utility and speed of our algorithm with data from several large-scale time-varying CID simulations. Our algorithm can achieve more than 80% of disk-space savings when compared with the existing techniques, while the isosurface extraction time is nearly optimal.

Planned Parenthood of Central New Jersey v. Farmer.

PubMed

2000-01-01

Court Decision: 762 Atlantic Reporter, 2d Series 620; 2000 Aug 15 (date of decision). The Supreme Court of New Jersey held that the state's Parental Notification for Abortion Act (Act) was unconstitutional because it violated the right to equal protection. Planned Parenthood of Central New Jersey brought an action to prohibit the enforcement of the Act. The New Jersey Supreme Court held that women, both minors and adults, have a fundamental right to decide whether to terminate their pregnancies. Although the state may impose restrictions on a minor's rights in an effort to protect the minor from her own immaturity, the Court found that the Act imposed restrictions on minors seeking abortions that it did not impose on minors seeking medical and surgical care relating to their pregnancies. The Act required parental notification for a minor seeking an abortion but did not require parental notification for a cesarean section, a considerably more difficult and complicated procedure. The court found there to be no substantial need for the Act and its distinction between the two classes of minors since "the state has recognized a minor's maturity in matters relating to her sexuality, reproductive decisions, substance-abuse treatment, and placing her children for adoption."

An Automated Method for High-Definition Transcranial Direct Current Stimulation Modeling*

PubMed Central

Huang, Yu; Su, Yuzhuo; Rorden, Christopher; Dmochowski, Jacek; Datta, Abhishek; Parra, Lucas C.

2014-01-01

Targeted transcranial stimulation with electric currents requires accurate models of the current flow from scalp electrodes to the human brain. Idiosyncratic anatomy of individual brains and heads leads to significant variability in such current flows across subjects, thus, necessitating accurate individualized head models. Here we report on an automated processing chain that computes current distributions in the head starting from a structural magnetic resonance image (MRI). The main purpose of automating this process is to reduce the substantial effort currently required for manual segmentation, electrode placement, and solving of finite element models. In doing so, several weeks of manual labor were reduced to no more than 4 hours of computation time and minimal user interaction, while current-flow results for the automated method deviated by less than 27.9% from the manual method. Key facilitating factors are the addition of three tissue types (skull, scalp and air) to a state-of-the-art automated segmentation process, morphological processing to correct small but important segmentation errors, and automated placement of small electrodes based on easily reproducible standard electrode configurations. We anticipate that such an automated processing will become an indispensable tool to individualize transcranial direct current stimulation (tDCS) therapy. PMID:23367144

A potential role of anti-poverty programs in health promotion

PubMed Central

Silverman, Kenneth; Holtyn, August F.; Jarvis, Brantley

2016-01-01

Poverty is one of the most pervasive risk factors underlying poor health, but is rarely targeted to improve health. Research on the effects of anti-poverty interventions on health has been limited, at least in part because funding for that research has been limited. Anti-poverty programs have been applied on a large scale, frequently by governments, but without systematic development and cumulative programmatic experimental studies. Anti-poverty programs that produce lasting effects on poverty have not been developed. Before evaluating the effect of anti-poverty programs on health, programs must be developed that can reduce poverty consistently. Anti-poverty programs require systematic development and cumulative programmatic scientific evaluation. Research on the therapeutic workplace could provide a model for that research and an adaptation of the therapeutic workplace could serve as a foundation of a comprehensive anti-poverty program. Once effective anti-poverty programs are developed, future research could determine if those programs improve health in addition to increasing income. The potential personal, health and economic benefits of effective anti-poverty programs could be substantial, and could justify the major efforts and expenses that would be required to support systematic research to develop such programs. PMID:27235603

A potential role of anti-poverty programs in health promotion.

PubMed

Silverman, Kenneth; Holtyn, August F; Jarvis, Brantley P

2016-11-01

Poverty is one of the most pervasive risk factors underlying poor health, but is rarely targeted to improve health. Research on the effects of anti-poverty interventions on health has been limited, at least in part because funding for that research has been limited. Anti-poverty programs have been applied on a large scale, frequently by governments, but without systematic development and cumulative programmatic experimental studies. Anti-poverty programs that produce lasting effects on poverty have not been developed. Before evaluating the effect of anti-poverty programs on health, programs must be developed that can reduce poverty consistently. Anti-poverty programs require systematic development and cumulative programmatic scientific evaluation. Research on the therapeutic workplace could provide a model for that research and an adaptation of the therapeutic workplace could serve as a foundation of a comprehensive anti-poverty program. Once effective anti-poverty programs are developed, future research could determine if those programs improve health in addition to increasing income. The potential personal, health and economic benefits of effective anti-poverty programs could be substantial, and could justify the major efforts and expenses that would be required to support systematic research to develop such programs. Copyright © 2016 Elsevier Inc. All rights reserved.

Livestock and human use of land: Productivity trends and dietary choices as drivers of future land and carbon dynamics

NASA Astrophysics Data System (ADS)

Weindl, Isabelle; Popp, Alexander; Bodirsky, Benjamin Leon; Rolinski, Susanne; Lotze-Campen, Hermann; Biewald, Anne; Humpenöder, Florian; Dietrich, Jan Philipp; Stevanović, Miodrag

2017-12-01

Land use change has been the primary driving force of human alteration of terrestrial ecosystems. With 80% of agricultural land dedicated to livestock production, the sector is an important lever to attenuate land requirements for food production and carbon emissions from land use change. In this study, we quantify impacts of changing human diets and livestock productivity on land dynamics and depletion of carbon stored in vegetation, litter and soils. Across all investigated productivity pathways, lower consumption of livestock products can substantially reduce deforestation (47-55%) and cumulative carbon losses (34-57%). On the supply side, already minor productivity growth in extensive livestock production systems leads to substantial CO2 emission abatement, but the emission saving potential of productivity gains in intensive systems is limited, also involving trade-offs with soil carbon stocks. If accounting for uncertainties related to future trade restrictions, crop yields and pasture productivity, the range of projected carbon savings from changing diets increases to 23-78%. Highest abatement of carbon emissions (63-78%) can be achieved if reduced consumption of animal-based products is combined with sustained investments into productivity increases in plant production. Our analysis emphasizes the importance to integrate demand- and supply-side oriented mitigation strategies and to combine efforts in the crop and livestock sector to enable synergies for climate protection.

An Automated Motion Detection and Reward System for Animal Training.

PubMed

Miller, Brad; Lim, Audrey N; Heidbreder, Arnold F; Black, Kevin J

2015-12-04

A variety of approaches has been used to minimize head movement during functional brain imaging studies in awake laboratory animals. Many laboratories expend substantial effort and time training animals to remain essentially motionless during such studies. We could not locate an "off-the-shelf" automated training system that suited our needs.  We developed a time- and labor-saving automated system to train animals to hold still for extended periods of time. The system uses a personal computer and modest external hardware to provide stimulus cues, monitor movement using commercial video surveillance components, and dispense rewards. A custom computer program automatically increases the motionless duration required for rewards based on performance during the training session but allows changes during sessions. This system was used to train cynomolgus monkeys (Macaca fascicularis) for awake neuroimaging studies using positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). The automated system saved the trainer substantial time, presented stimuli and rewards in a highly consistent manner, and automatically documented training sessions. We have limited data to prove the training system's success, drawn from the automated records during training sessions, but we believe others may find it useful. The system can be adapted to a range of behavioral training/recording activities for research or commercial applications, and the software is freely available for non-commercial use.

Epilepsy and Autism: Is there a special relationship?

PubMed Central

Berg, Anne T.; Plioplys, Sigita

2012-01-01

Increasingly, there has been an interest in the association between epilepsy and autism. The high frequency of autism in some of the early-onset developmental encephalopathic epilepsies is frequently cited as evidence of the relationship between autism and epilepsy. While these specific forms of epilepsy carry a higher than expected risk of autism, most if not all of the association may be due to intellectual disability (ID). The high prevalence of interictal EEG discharges in children with autism is also cited as further evidence although errors in the diagnosis of epilepsy seem to account for at least part of those findings. The prevalence of ID is substantially elevated in children with either epilepsy or autism. In the absence of ID, there is little evidence of a substantial, if any, increased risk of autism in children with epilepsy. Further, although the reported prevalence of autism has increased over the last several years, much of this increase may be attributable to changes in diagnostic practices, conceptualization of autism in the presence of ID, and laws requiring provision of services for children with autism. In the context of these temporal trends, any further efforts to tease apart the relationships between epilepsy, ID, and autism will have to address head-on the accuracy of diagnosis of all three conditions before we can determine whether there is indeed a special relationship between autism and epilepsy. PMID:22381386

Renal denervation and hypertension.

PubMed

Schlaich, Markus P; Krum, Henry; Sobotka, Paul A; Esler, Murray D

2011-06-01

Essential hypertension remains one of the biggest challenges in medicine with an enormous impact on both individual and society levels. With the exception of relatively rare monogenetic forms of hypertension, there is now general agreement that the condition is multifactorial in nature and hence requires therapeutic approaches targeting several aspects of the underlying pathophysiology. Accordingly, all major guidelines promote a combination of lifestyle interventions and combination pharmacotherapy to reach target blood pressure (BP) levels in order to reduce overall cardiovascular risk in affected patients. Although this approach works for many, it fails in a considerable number of patients for various reasons including drug-intolerance, noncompliance, physician inertia, and others, leaving them at unacceptably high cardiovascular risk. The quest for additional therapeutic approaches to safely and effectively manage hypertension continues and expands to the reappraisal of older concepts such as renal denervation. Based on the robust preclinical and clinical data surrounding the role of renal sympathetic nerves in various aspects of BP control very recent efforts have led to the development of a novel catheter-based approach using radiofrequency (RF) energy to selectively target and disrupt the renal nerves. The available evidence from the limited number of uncontrolled hypertensive patients in whom renal denervation has been performed are auspicious and indicate that the procedure has a favorable safety profile and is associated with a substantial and presumably sustained BP reduction. Although promising, a myriad of questions are far from being conclusively answered and require our concerted research efforts to explore the full potential and possible risks of this approach. Here we briefly review the science surrounding renal denervation, summarize the current data on safety and efficacy of renal nerve ablation, and discuss some of the open questions that need to be addressed in the near future.

Re-engineering the Federal planning process: A total Federal planning strategy, integrating NEPA with modern management tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eccleston, C.H.

1997-09-05

The National Environmental Policy Act (NEPA) of 1969 was established by Congress more than a quarter of a century ago, yet there is a surprising lack of specific tools, techniques, and methodologies for effectively implementing these regulatory requirements. Lack of professionally accepted techniques is a principal factor responsible for many inefficiencies. Often, decision makers do not fully appreciate or capitalize on the true potential which NEPA provides as a platform for planning future actions. New approaches and modem management tools must be adopted to fully achieve NEPA`s mandate. A new strategy, referred to as Total Federal Planning, is proposed formore » unifying large-scale federal planning efforts under a single, systematic, structured, and holistic process. Under this approach, the NEPA planning process provides a unifying framework for integrating all early environmental and nonenvironmental decision-making factors into a single comprehensive planning process. To promote effectiveness and efficiency, modem tools and principles from the disciplines of Value Engineering, Systems Engineering, and Total Quality Management are incorporated. Properly integrated and implemented, these planning tools provide the rigorous, structured, and disciplined framework essential in achieving effective planning. Ultimately, the goal of a Total Federal Planning strategy is to construct a unified and interdisciplinary framework that substantially improves decision-making, while reducing the time, cost, redundancy, and effort necessary to comply with environmental and other planning requirements. At a time when Congress is striving to re-engineer the governmental framework, apparatus, and process, a Total Federal Planning philosophy offers a systematic approach for uniting the disjointed and often convoluted planning process currently used by most federal agencies. Potentially this approach has widespread implications in the way federal planning is approached.« less

Understanding crop genetic diversity under modern plant breeding.

PubMed

Fu, Yong-Bi

2015-11-01

Maximizing crop yield while at the same time minimizing crop failure for sustainable agriculture requires a better understanding of the impacts of plant breeding on crop genetic diversity. This review identifies knowledge gaps and shows the need for more research into genetic diversity changes under plant breeding. Modern plant breeding has made a profound impact on food production and will continue to play a vital role in world food security. For sustainable agriculture, a compromise should be sought between maximizing crop yield under changing climate and minimizing crop failure under unfavorable conditions. Such a compromise requires better understanding of the impacts of plant breeding on crop genetic diversity. Efforts have been made over the last three decades to assess crop genetic diversity using molecular marker technologies. However, these assessments have revealed some temporal diversity patterns that are largely inconsistent with our perception that modern plant breeding reduces crop genetic diversity. An attempt was made in this review to explain such discrepancies by examining empirical assessments of crop genetic diversity and theoretical investigations of genetic diversity changes over time under artificial selection. It was found that many crop genetic diversity assessments were not designed to assess diversity impacts from specific plant breeding programs, while others were experimentally inadequate and contained technical biases from the sampling of cultivars and genomes. Little attention has been paid to theoretical investigations on crop genetic diversity changes from plant breeding. A computer simulation of five simplified breeding schemes showed the substantial effects of plant breeding on the retention of heterozygosity over generations. It is clear that more efforts are needed to investigate crop genetic diversity in space and time under plant breeding to achieve sustainable crop production.

40 CFR 33.301 - What does this subpart require?

Code of Federal Regulations, 2014 CFR

2014-07-01

... AGENCY PROGRAMS Good Faith Efforts § 33.301 What does this subpart require? A recipient, including one... good faith efforts whenever procuring construction, equipment, services and supplies under an EPA...

40 CFR 33.301 - What does this subpart require?

Code of Federal Regulations, 2013 CFR

2013-07-01

... AGENCY PROGRAMS Good Faith Efforts § 33.301 What does this subpart require? A recipient, including one... good faith efforts whenever procuring construction, equipment, services and supplies under an EPA...

40 CFR 33.301 - What does this subpart require?

Code of Federal Regulations, 2012 CFR

2012-07-01

... AGENCY PROGRAMS Good Faith Efforts § 33.301 What does this subpart require? A recipient, including one... good faith efforts whenever procuring construction, equipment, services and supplies under an EPA...

40 CFR 33.301 - What does this subpart require?

Code of Federal Regulations, 2011 CFR

2011-07-01

... AGENCY PROGRAMS Good Faith Efforts § 33.301 What does this subpart require? A recipient, including one... good faith efforts whenever procuring construction, equipment, services and supplies under an EPA...

Informal optics education and outreach programs in Southern California

NASA Astrophysics Data System (ADS)

Silberman, Donn M.; Cartland, Robert; Monacelli, Brian; Whitmore, Desire

2010-08-01

Over the past decade, Southern California has seen informal optics education and outreach programs grow substantially, mainly due to efforts from members of the Optical Society of Southern California (OSSC) and more recently the Optical Society of America, UC Irvine, Student Chapter. Also, the Optics Institute of Southern California (OISC) has served as a focal point for many of these programs, as an independent organization working closely with society members and other partners. This paper provides an update of these programs, including a new OSSC website that provides a new platform for significantly expanding the member participation efforts.

A review of Soviet plasma engine development

NASA Technical Reports Server (NTRS)

Barnett, John W.

1990-01-01

The Soviet Union has maintained a substantial and successful electric propulsion research and development effort since the 1950s; however, American researchers are generally unfamiliar with the Soviet accomplishments. Sources of information about Soviet electric propulsion research are noted. The development of plasma engines, a subset of the electric propulsion effort, is reviewed using numerous Soviet sources. The operational principles and status of several engines of the closed electron drift and high-current types are discussed. With recognition of the limited knowledge of the current Soviet program, the Soviet and American programs are compared, revealing some differences in program formulation and emphasis.

The Future of Geomagnetic Storm Predictions: Implications from Recent Solar and Interplanetary Observations

NASA Technical Reports Server (NTRS)

Tsurutani, B. T.; Gonzalez, W. D.

1995-01-01

Within the last 7-8 years, there has been a substantial growth in out knowledge of the solar and interplanetary causes of geomagnetic storms at Earth. This review article will not attempt to cover all of the work done during this period. This can be found elsewhere. Our emphasis here will be on recent efforts that expose important, presently unanswered questions that must be addressed and solved before true predictability of storms can be possible. Hopefully, this article will encourage some readers to join this effort and perhaps make major contributions to the field.

Supplementary immunization activities to achieve measles elimination: experience of the European Region.

PubMed

Khetsuriani, Nino; Deshevoi, Sergei; Goel, Ajay; Spika, John; Martin, Rebecca; Emiroglu, Nedret

2011-07-01

Supplementary immunization activities (SIAs) using measles-containing vaccine (MCV) have had a substantial impact on reducing mortality associated with measles worldwide. To assess impact of SIAs on measles incidence in the World Health Organization European Region and their role at the final stages of measles elimination efforts in Europe, we reviewed information on SIAs, measles surveillance, and routine vaccination coverage during 2000-2009. During 2000-2009, >57 million persons received MCV through SIAs in 16 countries. The Region primarily focused on catch-up campaigns with wider target age groups than in other regions and subsequently relied on routine vaccination rather than periodic follow-up SIAs for the second MCV dose. In addition, the concept of SIAs has been expanded from short-term (<30 days) mass campaigns implemented in other regions to incorporate vaccination efforts over longer periods and outbreak response vaccination. In 2009, 14 of 16 countries that conducted SIAs reported no measles cases or <1 case per 1,000,000 population, reflecting the post-SIA decrease in incidence. SIAs have made a substantial contribution to the success of measles elimination efforts and will likely remain an important strategy for interrupting measles virus transmission in the European Region, although specific approaches will vary by country. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2011.

[Health education in schools in Argentina: an art contest as a motivating activity].

PubMed

Darnaud, Raquel; Dato, María Isabel

2009-02-01

The purpose of this study was to plan health education efforts that integrate the health and education sectors. From March to November 2004, an art contest was held for 7th-9th grade students in 109 schools in 11 of Argentina's provinces. The contest allowed improvements in knowledge to be measured and adjustments to be made to the curriculum. The students created works of art featuring tuberculosis. To evaluate knowledge acquired, two provinces were chosen at random. Student knowledge had increased from 67.2% to 96.4%. The administrators and teachers testified to the usefulness of the materials developed. These results show that when the efforts of health and education sectors are coordinated and the appropriate materials are leveraged, the efforts of educators can be substantially bolstered.

Nuclear Rocket Technology Conference

NASA Technical Reports Server (NTRS)

1966-01-01

The Lewis Research Center has a strong interest in nuclear rocket propulsion and provides active support of the graphite reactor program in such nonnuclear areas as cryogenics, two-phase flow, propellant heating, fluid systems, heat transfer, nozzle cooling, nozzle design, pumps, turbines, and startup and control problems. A parallel effort has also been expended to evaluate the engineering feasibility of a nuclear rocket reactor using tungsten-matrix fuel elements and water as the moderator. Both of these efforts have resulted in significant contributions to nuclear rocket technology. Many successful static firings of nuclear rockets have been made with graphite-core reactors. Sufficient information has also been accumulated to permit a reasonable Judgment as to the feasibility of the tungsten water-moderated reactor concept. We therefore consider that this technoIogy conference on the nuclear rocket work that has been sponsored by the Lewis Research Center is timely. The conference has been prepared by NASA personnel, but the information presented includes substantial contributions from both NASA and AEC contractors. The conference excludes from consideration the many possible mission requirements for nuclear rockets. Also excluded is the direct comparison of nuclear rocket types with each other or with other modes of propulsion. The graphite reactor support work presented on the first day of the conference was partly inspired through a close cooperative effort between the Cleveland extension of the Space Nuclear Propulsion Office (headed by Robert W. Schroeder) and the Lewis Research Center. Much of this effort was supervised by Mr. John C. Sanders, chairman for the first day of the conference, and by Mr. Hugh M. Henneberry. The tungsten water-moderated reactor concept was initiated at Lewis by Mr. Frank E. Rom and his coworkers. The supervision of the recent engineering studies has been shared by Mr. Samuel J. Kaufman, chairman for the second day of the conference, and Mr. Roy V. Humble. Dr. John C. Eward served as general chairman for the conference.

19 CFR 134.35 - Articles substantially changed by manufacture.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Articles substantially changed by manufacture. 134...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.35 Articles substantially changed by manufacture. (a) Articles other than goods of a NAFTA country. An article used in the...

19 CFR 134.35 - Articles substantially changed by manufacture.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles substantially changed by manufacture. 134...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.35 Articles substantially changed by manufacture. (a) Articles other than goods of a NAFTA country. An article used in the...

19 CFR 134.35 - Articles substantially changed by manufacture.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Articles substantially changed by manufacture. 134...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.35 Articles substantially changed by manufacture. (a) Articles other than goods of a NAFTA country. An article used in the...

Are Cognitive Control and Stimulus-Driven Processes Differentially Linked to Inattention and Hyperactivity in Preschoolers?

ERIC Educational Resources Information Center

Miller, Carlin J.; Miller, Scott R.; Healey, Dione M.; Marshall, Katie; Halperin, Jeffrey M.

2013-01-01

Temperament and attention-deficit/hyperactivity disorder (ADHD) are both typically viewed as biologically based behavioural constructs. There is substantial overlap between ADHD symptoms and specific temperamental traits, such as effortful control, especially in young children. Recent work by Martel and colleagues (2009, 2011) suggests that…

7 CFR 635.4 - Failure to fully comply.

Code of Federal Regulations, 2010 CFR

2010-01-01

... to participants who are determined by the Chief to have made a good faith effort to comply fully with... whether a participant acted in good faith and rendered substantial performance under paragraph (b) of this..., the Chief, or designee, may grant relief in accordance with § 635.5 if the participant made a good...

The Relationship between Proficiency in French and Academic Achievement for Students in Saint Martin

ERIC Educational Resources Information Center

Wilson, Martin Ezikiel

2013-01-01

School administrators and educational policy makers have made a substantial effort to address the learning needs of students in Saint Martin, yet the achievement gap between students in Saint Martin and students in metropolitan France still persists. Risk factors such as family structure, socioeconomic status, immigration, and difficulty of…

Methods for shorebird surveys in the Arctic

Treesearch

Jonathan Bart; Susan L. Earnst

2005-01-01

A substantial effort is being made to develop a longterm monitoring program for shorebirds in North American (Brown et al. 2000, Donaldson et al. 2001, Bart et al. this volume). The current program, PRISM (Program for Regional and International Shorebird Monitoring), has four segments: arctic and boreal breeding surveys, temperate breeding surveys, temperate non-...

Increasing importance of deposition of reduced nitrogen in the United States

Treesearch

Yi Li; Bret A. Schichtel; John T. Walker; Donna B. Schwede; Xi Chen; Christopher M. B. Lehmann; Melissa A. Puchalski; David A. Gay; Jeffrey L. Collett

2016-01-01

Rapid development of agriculture and fossil fuel combustion greatly increased US reactive nitrogen emissions to the atmosphere in the second half of the 20th century, resulting in excess nitrogen deposition to natural ecosystems. Recent efforts to lower nitrogen oxides emissions have substantially decreased nitrate wet deposition. Levels of wet ammonium...

A Voice Crying in the Wilderness: Legislative Oversight Agencies' Efforts to Achieve Utilization

ERIC Educational Resources Information Center

VanLandingham, Gary R.

2006-01-01

While legislative oversight offices, like many evaluation and policy analysis units, face substantial challenges in promoting use of their work by policymakers, they often have not taken steps to overcome these challenges by adopting the strategies suggested by the evaluation literature. Although the offices seek utilization, they have not fully…

Carbon debt and carbon sequestration parity in forest bioenergy production

Treesearch

S.R. Mitchell; M.E. Harmon; K.B. O' Connell

2012-01-01

The capacity for forests to aid in climate change mitigation efforts is substantial but will ultimately depend on their management. If forests remain unharvested, they can further mitigate the increases in atmospheric CO2 that result from fossil fuel combustion and deforestation. Alternatively, they can be harvested for bioenergy production and...

Economic values of metro nature health benefits: A life course approach

Treesearch

Kathleen L. Wolf; Marcus K. Measells; Stephen C. Grado; Alicia S.T. Robbins

2015-01-01

tThe presence of metro nature enables daily environmental interactions, and a substantial body of evi-dence now demonstrates that nature contact generates extensive psychosocial, cognitive, and physicalhealth and well-being benefits. Estimates of the economic values of such benefits have lagged similarvaluation efforts for environmental services (such as improved air...

Increasing Baccalaureate Degree Attainment in Louisville: A Proposed Blueprint for Community Action

ERIC Educational Resources Information Center

Business-Higher Education Forum (NJ1), 2009

2009-01-01

Across the country, cities and regions have used community-wide partnerships to improve the educational attainment of their citizens. The most established of these partnerships have seen substantial education gains during their tenure. The community of Louisville, Kentucky has embarked on a similar effort to improve educational attainment. Nearly…

Turbocharged Diesels

NASA Technical Reports Server (NTRS)

1984-01-01

In a number of feasibility studies of turbine rotor designs, engineers of Cummins Engine Company, Inc.'s turbocharger group have utilized a computer program from COSMIC. Part of Cummins research effort is aimed toward introduction of advanced turbocharged engines that deliver extra power with greater fuel efficiency. Company claims use of COSMIC program substantially reduced software development costs.

Development of Independence among Future Primary School Teachers by Applying Interactive Learning Methods

ERIC Educational Resources Information Center

Rotova, Natalia Alexandrovna

2018-01-01

The necessity to develop independence among future primary school teachers during the process of studying in higher education institutions is substantiated. The essentials of independence notion are disclosed as efforts of students aimed at reaching the goals single-handedly. The results of the ascertaining experiment on defining the level of…

State Efforts to Strengthen School Leadership: Insights from CCSSO Action Groups

ERIC Educational Resources Information Center

Riley, Derek L.; Meredith, Julie

2017-01-01

Many states across the nation are working to improve school leadership, some on a substantial scale. Several factors encourage state-level work focused on principals, including: research evidence of principal effects on student learning, flexibility in the Every Student Succeeds Act (ESSA), new national professional standards for principals,…

Social Networks and Parent Motivational Beliefs: Evidence from an Urban School District

ERIC Educational Resources Information Center

Curry, Katherine A.; Jean-Marie, Gaëtane; Adams, Curt M.

2016-01-01

Background: Despite devotion of substantial resources and effort to increase parent/school partnerships, gaps remain between policy rhetoric and practice, especially in high-poverty communities. Current research focuses on parent involvement or effects of parent motivational beliefs on parent choice for behavior; however, it does not address the…

College Environment, Student Involvement, and Intellectual Development: Evidence in China

ERIC Educational Resources Information Center

Chi, Xianglan; Liu, Jinlan; Bai, Yin

2017-01-01

China's higher education system has been marked by dramatic growth since 1999. In response to calls for quality assurance, substantial efforts have been made to improve collegiate environments and enhance student learning. However, only limited empirical research has been conducted to investigate the effects of the college environment on student…

Preservation Challenges in a Changing Political Climate: A Report from Russia.

ERIC Educational Resources Information Center

Kislovskaya, Galina

In Russia today, substantial political, economic, and social changes directly affect the preservation efforts of libraries and archives. Prepared by the Deputy Director General of the M. I. Rudomino All-Russia State Library for Foreign Literature in Moscow, this report presents a distinctly Russian perspective on the ways in which libraries and…

The Role of Job Challenge and Organizational Identification in Enhancing Creative Behavior among Employees in the Workplace

ERIC Educational Resources Information Center

Carmeli, Abraham; Cohen-Meitar, Ravit; Elizur, Dov

2007-01-01

Organizations recognize the importance of creative employees and constantly explore ways to enhance their employees' creative behavior. Creativity research has directed substantial efforts to understanding how work environment fosters creativity. Yet, this research has paid little attention to the importance of specific characteristics of the work…

Balancing Good Intentions: Protecting the Privacy of Electronic Health Information

ERIC Educational Resources Information Center

McClanahan, Kitty

2008-01-01

Electronic information is a vital but complex component in the modern health care system, fueling ongoing efforts to develop a universal electronic health record infrastructure. This innovation creates a substantial tension between two desirable values: the increased quality and utility of patient medical records and the protection of the privacy…

Exuberant and Inhibited Children: Person-Centered Profiles and Links to Social Adjustment

ERIC Educational Resources Information Center

Dollar, Jessica M.; Stifter, Cynthia A.; Buss, Kristin A.

2017-01-01

The current study aimed to substantiate and extend our understanding regarding the existence and developmental pathways of 3 distinct temperament profiles--exuberant, inhibited, and average approach--in a sample of 3.5-year-old children (n = 121). The interactions between temperamental styles and specific types of effortful control, inhibitory…

Child Care Lead Poisoning Prevention. Training Curriculum.

ERIC Educational Resources Information Center

California Dept. of Health Services, Oakland. Childhood Lead Poisoning Prevention Branch.

In an effort to address young children's substantial risk for exposure to lead in out-of-home child care programs, outreach and training were developed for child care providers. This workshop curriculum consists of training activities and materials appropriate for child care providers in centers or homes for the purpose of educating them about the…

Sensitivity of summer stream temperatures to climate variability in the Pacific Northwest

Treesearch

Charles Luce; Brian Staab; Marc Kramer; Seth Wenger; Dan Isaak; Callie McConnell

2014-01-01

Estimating the thermal response of streams to a warming climate is important for prioritizing native fish conservation efforts. While there are plentiful estimates of air temperature responses to climate change, the sensitivity of streams, particularly small headwater streams, to warming temperatures is less well understood. A substantial body of literature correlates...

37 CFR 11.10 - Restrictions on practice in patent matters.

Code of Federal Regulations, 2010 CFR

2010-07-01

... or peripheral issue. A finding of substantiality should be based not only on the effort devoted to a... sufficient to suggest the relationship of the prior matter to his or her former office, e.g., technology... Department of Commerce for information concerning applicable post-employment restrictions. (d) An employee of...

Hospital CRM: unexplored frontier of revenue growth?

PubMed

Young, Thomas

2007-10-01

Customer relationship management (CRM) has a less-than-stellar reputation, in large part because efforts to implement it have been piecemeal and not well funded. The technologies now exist to make CRM much more effective than it has been in the past. Many hospitals today are demonstrating a substantial ROI from implementing a comprehensive CRM program.

The Behavioral Pharmacology of Effort-Related Choice Behavior: Dopamine, Adenosine and beyond

ERIC Educational Resources Information Center

Salamone, John D.; Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Pardo, Marta

2012-01-01

For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the "rewarding" impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic DA are undergoing a substantial conceptual restructuring, with the traditional emphasis on hedonia and primary reward yielding…

Environmental E.coli isolate characterization and selection as improved indicators for pathogens associated with produce contamination

USDA-ARS?s Scientific Manuscript database

Contamination of food and water by pathogens is a substantial public health issue in the United States. According to the Centers for Disease Control and Prevention, 49% of foodborne illness is caused by produce, and despite efforts to reduce produce contamination, these issues persist. Escherichia c...

76 FR 14099 - Proposed Collection of Information for an Evaluation of the Young Parents Demonstration Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

... design is having a single, persistent intervention for the treatment group that is substantially different from what the control group receives. Each of the grantees is implementing one of the following... its continuing effort to reduce paperwork and respondent burden, conducts a pre-clearance consultation...

Replication in Practice: Lessons from Five Lead Agencies

ERIC Educational Resources Information Center

McGonigel, Mary

2005-01-01

This article describes the replication efforts of five programs funded by the Pritzker Early Childhood Foundation and determines what methods are key to replication success. Before replication can take place, the lead agency must have substantial evidence of its effectiveness and know its core elements. It must also think carefully about how its…

The Dissemination and Implementation of Evidence-Based Psychological Treatments: A Review of Current Efforts

ERIC Educational Resources Information Center

McHugh, R. Kathryn; Barlow, David H.

2010-01-01

Recognizing an urgent need for increased access to evidenced-based psychological treatments, public health authorities have recently allocated over $2 billion to better disseminate these interventions. In response, implementation of these programs has begun, some of it on a very large scale, with substantial implications for the science and…

Human Cutaneous Anthrax, Georgia 2010–2012

PubMed Central

Kracalik, Ian; Malania, Lile; Tsertsvadze, Nikoloz; Manvelyan, Julietta; Bakanidze, Lela; Imnadze, Paata; Tsanava, Shota

2014-01-01

We assessed the occurrence of human cutaneous anthrax in Georgia during 2010–-2012 by examining demographic and spatial characteristics of reported cases. Reporting increased substantially, as did clustering of cases near urban centers. Control efforts, including education about anthrax and livestock vaccination, can be directed at areas of high risk. PMID:24447721

A Research Update on Correlates of Heavy Episodic Drinking among Undergraduate College Students

ERIC Educational Resources Information Center

Montauti, Sara Barrows; Bulmer, Sandra Minor

2014-01-01

Background: Despite prevention efforts of colleges and universities across the nation, there have been no substantial decreases in heavy episodic drinking among undergraduates over the past 2 decades. Purpose: This study provides an update on correlates of heavy episodic drinking for a recent cohort of undergraduate college students. Methods: A…

School Culture Benchmarks: Bridges and Barriers to Successful Bullying Prevention Program Implementation

ERIC Educational Resources Information Center

Coyle, H. Elizabeth

2008-01-01

A substantial body of research indicates that positive school culture benchmarks are integrally tied to the success of school reform and change in general. Additionally, an emerging body of research suggests a similar role for school culture in effective implementation of school violence prevention and intervention efforts. However, little…

Low-Cost Behavioral Nudges Increase Medicaid Take-Up Among Eligible Residents Of Oregon.

PubMed

Wright, Bill J; Garcia-Alexander, Ginny; Weller, Margarette A; Baicker, Katherine

2017-05-01

Efforts to reduce the ranks of the uninsured hinge on take-up of available programs and subsidies, but take-up of even free insurance is often less than complete. The evidence of the effectiveness of policies aiming to increase take-up is limited. We used a randomized controlled design to evaluate the impact of improved communication and behaviorally informed "nudges" designed to increase Medicaid take-up among eligible populations. Fielding randomized interventions in two different study populations in Oregon, we found that even very low-cost interventions substantially increased enrollment. Effects were larger in a population whose members had already expressed interest in obtaining coverage, but the effects were more persistent in low-income populations whose members were already enrolled in other state assistance programs but had not expressed interest in health insurance. The effects were similar across different demographic groups. Our results suggest that improving the design of enrollment processes and using low-cost mass-outreach efforts have the potential to substantially increase insurance coverage of vulnerable populations. Project HOPE—The People-to-People Health Foundation, Inc.

The Challenging Pupil in the Classroom: Child Effects on Teachers

PubMed Central

Houts, Renate M.; Caspi, Avshalom; Pianta, Robert C.; Arseneault, Louise; Moffitt, Terrie E.

2012-01-01

Teaching children requires effort and some children naturally require more effort than others. This study tests whether teacher effort devoted to individual children varies as a function of children’s personal characteristics. Using a nation-wide longitudinal study of twins followed between ages 5-12 years, we asked teachers about the effort they invested in each child enrolled in our study. We found that teacher effort was a function of heritable child characteristics; that children’s challenging behavior assessed at age 5 predicted teacher effort at age 12; and that challenging child behavior and teacher effort share common etiology in children’s genes. While child effects accounted for a significant proportion of variance in teacher effort, we also found variation that could not be attributed to children’s behavior. Treating children with challenging behavior and enhancing teachers’ skills in behavior management could increase the time and energy teachers have to deliver curriculum in their classrooms. PMID:21078897

Spatial pattern formation facilitates eradication of infectious diseases

PubMed Central

Eisinger, Dirk; Thulke, Hans-Hermann

2008-01-01

Control of animal-born diseases is a major challenge faced by applied ecologists and public health managers. To improve cost-effectiveness, the effort required to control such pathogens needs to be predicted as accurately as possible. In this context, we reviewed the anti-rabies vaccination schemes applied around the world during the past 25 years. We contrasted predictions from classic approaches based on theoretical population ecology (which governs rabies control to date) with a newly developed individual-based model. Our spatially explicit approach allowed for the reproduction of pattern formation emerging from a pathogen's spread through its host population. We suggest that a much lower management effort could eliminate the disease than that currently in operation. This is supported by empirical evidence from historic field data. Adapting control measures to the new prediction would save one-third of resources in future control programmes. The reason for the lower prediction is the spatial structure formed by spreading infections in spatially arranged host populations. It is not the result of technical differences between models. Synthesis and applications. For diseases predominantly transmitted by neighbourhood interaction, our findings suggest that the emergence of spatial structures facilitates eradication. This may have substantial implications for the cost-effectiveness of existing disease management schemes, and suggests that when planning management strategies consideration must be given to methods that reflect the spatial nature of the pathogen–host system. PMID:18784795

Air pollution in India and related adverse respiratory health effects: past, present, and future directions.

PubMed

Khilnani, Gopi C; Tiwari, Pawan

2018-03-01

The review describes current status of air pollution in India, summarizes recent research on adverse health effects of ambient and household air pollution, and outlines the ongoing efforts and future actions required to improve air quality and reduce morbidity and mortality because of air pollution in India. Global burden of disease data analysis reveals more than one million premature deaths attributable to ambient air pollution in 2015 in India. More than one million additional deaths can be attributed to household air pollution. Particulate matter with diameter 2.5 μm or less has been causatively linked with most premature deaths. Acute respiratory tract infections, asthma, chronic obstructive pulmonary disease, exacerbations of preexisting obstructive airway disease and lung cancer are proven adverse respiratory effects of air pollution. Targeting air quality standards laid by WHO can significantly reduce morbidity and mortality because of air pollution in India. India is currently exposed to high levels of ambient and household air pollutants. Respiratory adverse effects of air pollution are significant contributors to morbidity and premature mortality in India. Substantial efforts are being made at legislative, administrative, and community levels to improve air quality. However, much more needs to be done to change the 'status quo' and attain the target air quality standards. VIDEO ABSTRACT: http://links.lww.com/COPM/A24.

Essential elements of personalized medicine.

PubMed

Burke, Wylie; Brown Trinidad, Susan; Press, Nancy A

2014-02-01

Genomic information has been promoted as the basis for "personalized" health care. We considered the benefits provided by genomic testing in context of the concept of personalized medicine. We evaluated current and potential uses of genomic testing in health care, using prostate cancer as an example, and considered their implications for individualizing or otherwise improving health care. Personalized medicine is most accurately seen as a comprehensive effort to tailor health care to the individual, spanning multiple dimensions. While genomic tests will offer many potential opportunities to improve the delivery of care, including the potential for genomic research to offer opportunities to improve prostate cancer screening and treatment, such advances do not in themselves constitute a paradigm shift in the delivery of health care. Rather, personalized medicine is based on a partnership between clinician and patient that utilizes shared decision making to determine the best health care options among the available choices, weighing the patient's personal values and preferences together with clinical findings. This approach is particularly important for difficult clinical decisions involving uncertainty and trade-offs, such as those involved in prostate cancer screening and management. The delivery of personalized medicine also requires adequate health care access and assurance that basic health needs have been met. Substantial research investment will be needed to identify how genomic tests can contribute to this effort. © 2014 Published by Elsevier Inc.

An analytical chemistry laboratory's experiences under Department of Energy Order 5633. 3 - a status report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bingham, C.D.

The U.S. Department of Energy (DOE) order 5633.3, Control and Accountability of Nuclear Materials, initiated substantial changes to the requirements for operations involving nuclear materials. In the opinion of this author, the two most significant changes are the clarification of and the increased emphasis on the concept of graded safeguards and the implementation of performance requirements. Graded safeguards recognizes that some materials are more attractive than others to potential adversary actions and, thus, should be afforded a higher level of integrated safeguards effort. An analytical chemistry laboratory, such as the New Brunswick Laboratory (NBL), typically has a small total inventorymore » of special nuclear materials compared to, for example, a production or manufacturing facility. The NBL has a laboratory information management system (LIMS) that not only provides the sample identification and tracking but also incorporates the essential features of MC A required of NBL operations. As a consequence of order 5633.3, NBL had to modify LIMS to accommodate material attractiveness information for the logging process, to reflect changes in the attractiveness as the material was processed through the laboratory, and to enable inventory information to be accumulated by material attractiveness as the material was processed through the laboratory, and to enable inventory information to be accumulated by material attractiveness codes.« less

40 CFR 33.302 - Are there any additional contract administration requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Good Faith Efforts § 33.302 Are there any additional contract... require its prime contractor to employ the six good faith efforts described in § 33.301 even if the prime... the subcontract for any reason, the recipient must require the prime contractor to employ the six good...

Security Modeling and Correctness Proof Using Specware and Isabelle

DTIC Science & Technology

2008-12-01

proving requires substantial knowledge and experience in logical calculus . 15. NUMBER OF PAGES 146 14. SUBJECT TERMS Formal Method, Theorem...although the actual proving requires substantial knowledge and experience in logical calculus . vi THIS PAGE INTENTIONALLY LEFT BLANK vii TABLE OF...formal language and provides tools for proving those formulas in a logical calculus ” [5]. We are demonstrating in this thesis that a specification in

PREPARING FOR EXASCALE: ORNL Leadership Computing Application Requirements and Strategy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joubert, Wayne; Kothe, Douglas B; Nam, Hai Ah

2009-12-01

In 2009 the Oak Ridge Leadership Computing Facility (OLCF), a U.S. Department of Energy (DOE) facility at the Oak Ridge National Laboratory (ORNL) National Center for Computational Sciences (NCCS), elicited petascale computational science requirements from leading computational scientists in the international science community. This effort targeted science teams whose projects received large computer allocation awards on OLCF systems. A clear finding of this process was that in order to reach their science goals over the next several years, multiple projects will require computational resources in excess of an order of magnitude more powerful than those currently available. Additionally, for themore » longer term, next-generation science will require computing platforms of exascale capability in order to reach DOE science objectives over the next decade. It is generally recognized that achieving exascale in the proposed time frame will require disruptive changes in computer hardware and software. Processor hardware will become necessarily heterogeneous and will include accelerator technologies. Software must undergo the concomitant changes needed to extract the available performance from this heterogeneous hardware. This disruption portends to be substantial, not unlike the change to the message passing paradigm in the computational science community over 20 years ago. Since technological disruptions take time to assimilate, we must aggressively embark on this course of change now, to insure that science applications and their underlying programming models are mature and ready when exascale computing arrives. This includes initiation of application readiness efforts to adapt existing codes to heterogeneous architectures, support of relevant software tools, and procurement of next-generation hardware testbeds for porting and testing codes. The 2009 OLCF requirements process identified numerous actions necessary to meet this challenge: (1) Hardware capabilities must be advanced on multiple fronts, including peak flops, node memory capacity, interconnect latency, interconnect bandwidth, and memory bandwidth. (2) Effective parallel programming interfaces must be developed to exploit the power of emerging hardware. (3) Science application teams must now begin to adapt and reformulate application codes to the new hardware and software, typified by hierarchical and disparate layers of compute, memory and concurrency. (4) Algorithm research must be realigned to exploit this hierarchy. (5) When possible, mathematical libraries must be used to encapsulate the required operations in an efficient and useful way. (6) Software tools must be developed to make the new hardware more usable. (7) Science application software must be improved to cope with the increasing complexity of computing systems. (8) Data management efforts must be readied for the larger quantities of data generated by larger, more accurate science models. Requirements elicitation, analysis, validation, and management comprise a difficult and inexact process, particularly in periods of technological change. Nonetheless, the OLCF requirements modeling process is becoming increasingly quantitative and actionable, as the process becomes more developed and mature, and the process this year has identified clear and concrete steps to be taken. This report discloses (1) the fundamental science case driving the need for the next generation of computer hardware, (2) application usage trends that illustrate the science need, (3) application performance characteristics that drive the need for increased hardware capabilities, (4) resource and process requirements that make the development and deployment of science applications on next-generation hardware successful, and (5) summary recommendations for the required next steps within the computer and computational science communities.« less

Cognitive dissonance in children: justification of effort or contrast?

PubMed

Alessandri, Jérôme; Darcheville, Jean-Claude; Zentall, Thomas R

2008-06-01

Justification of effort is a form of cognitive dissonance in which the subjective value of an outcome is directly related to the effort that went into obtaining it. However, it is likely that in social contexts (such as the requirements for joining a group) an inference can be made (perhaps incorrectly) that an outcome that requires greater effort to obtain in fact has greater value. Here we present evidence that a cognitive dissonance effect can be found in children under conditions that offer better control for the social value of the outcome. This effect is quite similar to contrast effects that recently have been studied in animals. We suggest that contrast between the effort required to obtain the outcome and the outcome itself provides a more parsimonious account of this phenomenon and perhaps other related cognitive dissonance phenomena as well. Research will be needed to identify cognitive dissonance processes that are different from contrast effects of this kind.

Generation of cell type-specific monoclonal antibodies for the planarian and optimization of sample processing for immunolabeling.

PubMed

Forsthoefel, David J; Waters, Forrest A; Newmark, Phillip A

2014-12-21

Efforts to elucidate the cellular and molecular mechanisms of regeneration have required the application of methods to detect specific cell types and tissues in a growing cohort of experimental animal models. For example, in the planarian Schmidtea mediterranea, substantial improvements to nucleic acid hybridization and electron microscopy protocols have facilitated the visualization of regenerative events at the cellular level. By contrast, immunological resources have been slower to emerge. Specifically, the repertoire of antibodies recognizing planarian antigens remains limited, and a more systematic approach is needed to evaluate the effects of processing steps required during sample preparation for immunolabeling. To address these issues and to facilitate studies of planarian digestive system regeneration, we conducted a monoclonal antibody (mAb) screen using phagocytic intestinal cells purified from the digestive tracts of living planarians as immunogens. This approach yielded ten antibodies that recognized intestinal epitopes, as well as markers for the central nervous system, musculature, secretory cells, and epidermis. In order to improve signal intensity and reduce non-specific background for a subset of mAbs, we evaluated the effects of fixation and other steps during sample processing. We found that fixative choice, treatments to remove mucus and bleach pigment, as well as methods for tissue permeabilization and antigen retrieval profoundly influenced labeling by individual antibodies. These experiments led to the development of a step-by-step workflow for determining optimal specimen preparation for labeling whole planarians as well as unbleached histological sections. We generated a collection of monoclonal antibodies recognizing the planarian intestine and other tissues; these antibodies will facilitate studies of planarian tissue morphogenesis. We also developed a protocol for optimizing specimen processing that will accelerate future efforts to generate planarian-specific antibodies, and to extend functional genetic studies of regeneration to post-transcriptional aspects of gene expression, such as protein localization or modification. Our efforts demonstrate the importance of systematically testing multiple approaches to species-specific idiosyncracies, such as mucus removal and pigment bleaching, and may serve as a template for the development of immunological resources in other emerging model organisms.

Forging the Solution to the Energy Challenge: The Role of Materials Science and Materials Scientists

NASA Astrophysics Data System (ADS)

Wadsworth, Jeffrey

2010-04-01

The energy challenge is central to the most important strategic problems facing the United States and the world. It is increasingly clear that even large-scale deployments of the best technologies available today cannot meet the rising energy demands of a growing world population. Achieving a secure and sustainable energy future will require full utilization of, and substantial improvements in, a comprehensive portfolio of energy systems and technologies. This goal is complicated by several factors. First, energy strategies are inextricably linked to national security and health issues. Second, in developing and deploying energy technologies, it is vital to consider not only environmental issues, such as global climate change, but also economic considerations, which strongly influence both public and political views on energy policy. Third, a significant and sustained effort in basic and applied research and development (R&D) will be required to deliver the innovations needed to ensure a desirable energy future. Innovations in materials science and engineering are especially needed to overcome the limits of essentially all energy technologies. A wealth of historical evidence demonstrates that such innovations are also the key to economic prosperity. From the development of the earliest cities around flint-trading centers, to the Industrial Revolution, to today’s silicon-based global economy, the advantage goes to those who lead in exploiting materials. I view our challenge by considering the rate of innovation and the transition of discovery to the marketplace as the relationship among R&D investment, a skilled and talented workforce, business innovations, and the activities of competitors. Most disturbing in analyzing this relationship is the need for trained workers in science, technology, engineering, and mathematics (STEM). To develop the STEM workforce needed for innovation, we need sustainable, positive change in STEM education at all levels from preschool through postgraduate. Materials sciences can be a significant magnet in attracting students to STEM areas, and a focused effort is needed to ensure that it is included in STEM programs. From this effort will come the next generation of materials scientists and the innovations that will enable us to overcome the energy challenge.

Forging the Solution to the Energy Challenge: The Role of Materials Science and Materials Scientists

NASA Astrophysics Data System (ADS)

Wadsworth, Jeffrey

2010-05-01

The energy challenge is central to the most important strategic problems facing the United States and the world. It is increasingly clear that even large-scale deployments of the best technologies available today cannot meet the rising energy demands of a growing world population. Achieving a secure and sustainable energy future will require full utilization of, and substantial improvements in, a comprehensive portfolio of energy systems and technologies. This goal is complicated by several factors. First, energy strategies are inextricably linked to national security and health issues. Second, in developing and deploying energy technologies, it is vital to consider not only environmental issues, such as global climate change, but also economic considerations, which strongly influence both public and political views on energy policy. Third, a significant and sustained effort in basic and applied research and development (R&D) will be required to deliver the innovations needed to ensure a desirable energy future. Innovations in materials science and engineering are especially needed to overcome the limits of essentially all energy technologies. A wealth of historical evidence demonstrates that such innovations are also the key to economic prosperity. From the development of the earliest cities around flint-trading centers, to the Industrial Revolution, to today’s silicon-based global economy, the advantage goes to those who lead in exploiting materials. I view our challenge by considering the rate of innovation and the transition of discovery to the marketplace as the relationship among R&D investment, a skilled and talented workforce, business innovations, and the activities of competitors. Most disturbing in analyzing this relationship is the need for trained workers in science, technology, engineering, and mathematics (STEM). To develop the STEM workforce needed for innovation, we need sustainable, positive change in STEM education at all levels from preschool through postgraduate. Materials sciences can be a significant magnet in attracting students to STEM areas, and a focused effort is needed to ensure that it is included in STEM programs. From this effort will come the next generation of materials scientists and the innovations that will enable us to overcome the energy challenge.

Non-communicable diseases: mapping research funding organisations, funding mechanisms and research practices in Italy and Germany.

PubMed

Stephani, Victor; Sommariva, Silvia; Spranger, Anne; Ciani, Oriana

2017-10-02

Evidence shows that territorial borders continue to have an impact on research collaboration in Europe. Knowledge of national research structural contexts is therefore crucial to the promotion of Europe-wide policies for research funding. Nevertheless, studies assessing and comparing research systems remain scarce. This paper aims to further the knowledge on national research landscapes in Europe, focusing on non-communicable disease (NCD) research in Italy and Germany. To capture the architecture of country-specific research funding systems, a three-fold strategy was adopted. First, a literature review was conducted to determine a list of key public, voluntary/private non-profit and commercial research funding organisations (RFOs). Second, an electronic survey was administered qualifying RFOs. Finally, survey results were integrated with semi-structured interviews with key opinion leaders in NCD research. Three major dimensions of interest were investigated - funding mechanisms, funding patterns and expectations regarding outputs. The number of RFOs in Italy is four times larger than that in Germany and the Italian research system has more project funding instruments than the German system. Regarding the funding patterns towards NCD areas, in both countries, respiratory disease research resulted as the lowest funded, whereas cancer research was the target of most funding streams. The most reported expected outputs of funded research activity were scholarly publication of articles and reports. This cross-country comparison on the Italian and German research funding structures revealed substantial differences between the two systems. The current system is prone to duplicated research efforts, popular funding for some diseases and intransparency of research results. Future research will require addressing the need for better coordination of research funding efforts, even more so if European research efforts are to play a greater role.

Transparent stakeholder engagement in practice: Lessons learned from applying comprehensive environmental assessment to research planning for nanomaterials.

PubMed

Powers, Christina; Hendren, Christine; Wang, Amy; Davis, J Michael

2014-10-01

As efforts to develop new applications of engineered nanoscale materials (ENMs) continue to grow, so too has interest in the environmental, health, and safety (EHS) implications of these materials. However, thorough evaluation and interpretation of such implications could require substantial resources (e.g., estimated as >$120 million per year in federal funding 2013-2017). A structured, strategic approach for transparently planning research would support improved linkages between ENM research and risk assessments, and thereby enhance the utility of financial and other resources for EHS studies of ENMs. For this reason, we applied Comprehensive Environmental Assessment (CEA) as an approach to provide transparent input into research planning for 2 types of ENMs: nanoscale titanium dioxide and nanoscale silver. For each of these CEA applications, we employed a collective judgment method known as Nominal Group Technique (NGT) in 2 workshops sponsored by the US Environmental Protection Agency (USEPA). The objective of this paper is to present the outcomes of these CEA applications in the context of how our methodology can inform future efforts to identify collective goals in science (e.g., research priorities) through structured decision support approaches. Outcomes include clear lists of research priorities for each ENM developed through transparently engaging stakeholders having diverse technical and sector perspectives. In addition, we identified several procedural aspects that could be refined, including emphasizing breakout group interactions, identifying broad information priorities before more detailed research questions, and using rating rather than ranking prioritization methods. Beyond the research directions identified for specific ENMs, lessons learned about engaging stakeholders in research planning are expected to inform future research planning efforts for ENMs and other emerging materials across the scientific community. © 2014 SETAC.

Seasonal prevalence of malaria in West Sumba district, Indonesia

PubMed Central

Syafruddin, Din; Krisin; Asih, Puji; Sekartuti; Dewi, Rita M; Coutrier, Farah; Rozy, Ismail E; Susanti, Augustina I; Elyazar, Iqbal RF; Sutamihardja, Awalludin; Rahmat, Agus; Kinzer, Michael; Rogers, William O

2009-01-01

Background Accurate information about the burden of malaria infection at the district or provincial level is required both to plan and assess local malaria control efforts. Although many studies of malaria epidemiology, immunology, and drug resistance have been conducted at many sites in Indonesia, there is little published literature describing malaria prevalence at the district, provincial, or national level. Methods Two stage cluster sampling malaria prevalence surveys were conducted in the wet season and dry season across West Sumba, Nusa Tenggara Province, Indonesia. Results Eight thousand eight hundred seventy samples were collected from 45 sub-villages in the surveys. The overall prevalence of malaria infection in the West Sumba District was 6.83% (95% CI, 4.40, 9.26) in the wet season and 4.95% (95% CI, 3.01, 6.90) in the dry. In the wet season Plasmodium falciparum accounted for 70% of infections; in the dry season P. falciparum and Plasmodium vivax were present in equal proportion. Malaria prevalence varied substantially across the district; prevalences in individual sub-villages ranged from 0–34%. The greatest malaria prevalence was in children and teenagers; the geometric mean parasitaemia in infected individuals decreased with age. Malaria infection was clearly associated with decreased haemoglobin concentration in children under 10 years of age, but it is not clear whether this association is causal. Conclusion Malaria is hypoendemic to mesoendemic in West Sumba, Indonesia. The age distribution of parasitaemia suggests that transmission has been stable enough to induce some clinical immunity. These prevalence data will aid the design of future malaria control efforts and will serve as a baseline against which the results of current and future control efforts can be assessed. PMID:19134197

Modeling the Health and Economic Burden of Hepatitis C Virus in Switzerland

PubMed Central

Müllhaupt, Beat; Bruggmann, Philip; Bihl, Florian; Blach, Sarah; Lavanchy, Daniel; Razavi, Homie; Semela, David; Negro, Francesco

2015-01-01

Background Chronic hepatitis C virus infection is a major cause of liver disease in Switzerland and carries a significant cost burden. Currently, only conservative strategies are in place to mitigate the burden of hepatitis C in Switzerland. This study expands on previously described modeling efforts to explore the impact of: no treatment, and treatment to reduce HCC and mortality. Furthermore, the costs associated with untreated HCV were modeled. Methods Hepatitis C disease progression and mortality were modeled. Baseline historical assumptions were collected from the literature and expert interviews and strategies were developed to show the impact of different levels of intervention (improved drug cure rates, treatment and diagnosis) until 2030. Results Under the historical standard of care, the number of advanced stage cases was projected to increase until 2030, at which point the annual economic burden of untreated viremic infections was projected to reach €96.8 (95% Uncertainty Interval: €36 – €232) million. Scenarios to reduce HCV liver-related mortality by 90% by 2030 required treatment of 4,190 ≥F2 or 3,200 ≥F3 patients annually by 2018 using antivirals with a 95% efficacy rate. Delaying the implementation of these scenarios by 2 or 5 years reduced the impact on mortality to 75% and 57%, respectively. Conclusions With today’s treatment efficacy and uptake rates, hepatitis C disease burden is expected to increase through 2030. A substantial reduction in disease burden can be achieved by means of both higher efficacy drugs and increased treatment uptake. However, these efforts cannot be undertaken without a simultaneous effort to diagnose more infections. PMID:26107467

How do feelings influence effort? An empirical study of entrepreneurs' affect and venture effort.

PubMed

Foo, Maw-Der; Uy, Marilyn A; Baron, Robert A

2009-07-01

How do feelings influence the effort of entrepreneurs? To obtain data on this issue, the authors implemented experience sampling methodology in which 46 entrepreneurs used cell phones to provide reports on their affect, future temporal focus, and venture effort twice daily for 24 days. Drawing on the affect-as-information theory, the study found that entrepreneurs' negative affect directly predicts entrepreneurs' effort toward tasks that are required immediately. Results were consistent for within-day and next-day time lags. Extending the theory, the study found that positive affect predicts venture effort beyond what is immediately required and that this relationship is mediated by future temporal focus. The mediating effects were significant only for next-day outcomes. Implications of findings on the nature of the affect-effort relationship for different time lags are discussed.

Analysis of Particle Content of Recombinant Adeno-Associated Virus Serotype 8 Vectors by Ion-Exchange Chromatography

PubMed Central

Lock, Martin; Alvira, Mauricio R.

2012-01-01

Abstract Advances in adeno-associated virus (AAV)-mediated gene therapy have brought the possibility of commercial manufacturing of AAV vectors one step closer. To realize this prospect, a parallel effort with the goal of ever-increasing sophistication for AAV vector production technology and supporting assays will be required. Among the important release assays for a clinical gene therapy product, those monitoring potentially hazardous contaminants are most critical for patient safety. A prominent contaminant in many AAV vector preparations is vector particles lacking a genome, which can substantially increase the dose of AAV capsid proteins and lead to possible unwanted immunological consequences. Current methods to determine empty particle content suffer from inconsistency, are adversely affected by contaminants, or are not applicable to all serotypes. Here we describe the development of an ion-exchange chromatography-based assay that permits the rapid separation and relative quantification of AAV8 empty and full vector particles through the application of shallow gradients and a strong anion-exchange monolith chromatography medium. PMID:22428980

Combined Regional Investments Could Substantially Enhance Health System Performance And Be Financially Affordable.

PubMed

Homer, Jack; Milstein, Bobby; Hirsch, Gary B; Fisher, Elliott S

2016-08-01

Leaders across the United States face a difficult challenge choosing among possible approaches to transform health system performance in their regions. The ReThink Health Dynamics Model simulates how alternative scenarios could unfold through 2040. This article compares the likely consequences if four interventions were enacted in layered combinations in a prototypical midsize US city. We estimated the effects of efforts to deliver higher-value care; reinvest savings and expand global payment; enable healthier behaviors; and expand socioeconomic opportunities. Results suggest that there may be an effective and affordable way to unlock much greater health and economic potential, ultimately reducing severe illness by 20 percent, lowering health care costs by 14 percent, and improving economic productivity by 9 percent. This would require combined investments in clinical and population-level initiatives, coupled with financial agreements that reduce incentives for costly care and reinvest a share of the savings to ensure adequate long-term financing. Project HOPE—The People-to-People Health Foundation, Inc.

Global challenges in water, sanitation and health.

PubMed

Moe, Christine L; Rheingans, Richard D

2006-01-01

The year 2005 marks the beginning of the "International Decade for Action: Water for Life" and renewed effort to achieve the Millennium Development Goals (MDGS) to reduce by half the proportion of the world's population without sustainable access to safe drinking water and sanitation by 2015. Currently, UNICEF and WHO estimate that 1.1 billion people lack access to improved water supplies and 2.6 billion people lack adequate sanitation. Providing safe water and basic sanitation to meet the MDGs will require substantial economic resources, sustainable technological solutions and courageous political will. We review five major challenges to providing safe water and sanitation on a global basis: (1) contamination of water in distribution systems, (2) growing water scarcity and the potential for water reuse and conservation, (3) implementing innovative low-cost sanitation systems, (4) providing sustainable water supplies and sanitation for megacities, and (5) reducing global and regional disparities in access to water and sanitation and developing financially sustainable water and sanitation services.

Aversive aftertaste changes visual food cue reactivity: An fMRI study on cross-modal perception.

PubMed

Wabnegger, Albert; Schwab, Daniela; Schienle, Anne

2018-04-23

In western cultures, we are surrounded by appealing visual food cues that stimulate our desire to eat, overeating and subsequent weight gain. Cognitive control of appetite (reappraisal) requires substantial attentional resources and effort in order to work. Therefore, we tested an alternative approach for appetite regulation via functional magnetic resonance imaging. Healthy, normal-weight women were presented with images depicting food (high-/low-caloric), once in combination with a bitter aftertaste (a gustatory stop signal) and once with a neutral taste (water), in a retest design. The aversive aftertaste elicited increased activation in the orbitofrontal/dorsolateral prefrontal cortex (OFC, DLPFC), striatum and frontal operculum during the viewing of high-caloric food (vs. low-caloric food). In addition, the increase in DLPFC activity to high-caloric food in the bitter condition was correlated with reported appetite reduction. The findings indicate that this aftertaste procedure was able to reduce the appetitive value of visual food cues. Copyright © 2018 Elsevier B.V. All rights reserved.

Monitoring, reporting and verifying emissions in the climate economy

NASA Astrophysics Data System (ADS)

Bellassen, Valentin; Stephan, Nicolas; Afriat, Marion; Alberola, Emilie; Barker, Alexandra; Chang, Jean-Pierre; Chiquet, Caspar; Cochran, Ian; Deheza, Mariana; Dimopoulos, Christopher; Foucherot, Claudine; Jacquier, Guillaume; Morel, Romain; Robinson, Roderick; Shishlov, Igor

2015-04-01

The monitoring, reporting and verification (MRV) of greenhouse-gas emissions is the cornerstone of carbon pricing and management mechanisms. Here we consider peer-reviewed articles and 'grey literature' related to existing MRV requirements and their costs. A substantial part of the literature is the regulatory texts of the 15 most important carbon pricing and management mechanisms currently implemented. Based on a comparison of key criteria such as the scope, cost, uncertainty and flexibility of procedures, we conclude that conventional wisdom on MRV is not often promoted in existing carbon pricing mechanisms. Quantification of emissions uncertainty and incentives to reduce this uncertainty are usually only partially applied, if at all. Further, the time and resources spent on small sources of emissions would be expected to be limited. Although provisions aiming at an effort proportionate to the amount of emissions at stake -- 'materiality' -- are widespread, they are largely outweighed by economies of scale: in all schemes, MRV costs per tonne are primarily driven by the size of the source.

An algorithm to improve speech recognition in noise for hearing-impaired listeners

PubMed Central

Healy, Eric W.; Yoho, Sarah E.; Wang, Yuxuan; Wang, DeLiang

2013-01-01

Despite considerable effort, monaural (single-microphone) algorithms capable of increasing the intelligibility of speech in noise have remained elusive. Successful development of such an algorithm is especially important for hearing-impaired (HI) listeners, given their particular difficulty in noisy backgrounds. In the current study, an algorithm based on binary masking was developed to separate speech from noise. Unlike the ideal binary mask, which requires prior knowledge of the premixed signals, the masks used to segregate speech from noise in the current study were estimated by training the algorithm on speech not used during testing. Sentences were mixed with speech-shaped noise and with babble at various signal-to-noise ratios (SNRs). Testing using normal-hearing and HI listeners indicated that intelligibility increased following processing in all conditions. These increases were larger for HI listeners, for the modulated background, and for the least-favorable SNRs. They were also often substantial, allowing several HI listeners to improve intelligibility from scores near zero to values above 70%. PMID:24116438

Nuclear power in the 21st century: Challenges and possibilities.

PubMed

Horvath, Akos; Rachlew, Elisabeth

2016-01-01

The current situation and possible future developments for nuclear power--including fission and fusion processes--is presented. The fission nuclear power continues to be an essential part of the low-carbon electricity generation in the world for decades to come. There are breakthrough possibilities in the development of new generation nuclear reactors where the life-time of the nuclear waste can be reduced to some hundreds of years instead of the present time-scales of hundred thousand of years. Research on the fourth generation reactors is needed for the realisation of this development. For the fast nuclear reactors, a substantial research and development effort is required in many fields--from material sciences to safety demonstration--to attain the envisaged goals. Fusion provides a long-term vision for an efficient energy production. The fusion option for a nuclear reactor for efficient production of electricity has been set out in a focussed European programme including the international project of ITER after which a fusion electricity DEMO reactor is envisaged.

Relativistic iron lines in accretion disks: the contribution of higher order images in the strong deflection limit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aldi, Giulio Francesco; Bozza, Valerio, E-mail: giuliofrancesco.aldi@sa.infn.it, E-mail: valboz@sa.infn.it

The shapes of relativistic iron lines observed in spectra of candidate black holes carry the signatures of the strong gravitational fields in which the accretion disks lie. These lines result from the sum of the contributions of all images of the disk created by gravitational lensing, with the direct and first-order images largely dominating the overall shapes. Higher order images created by photons tightly winding around the black holes are often neglected in the modeling of these lines, since they require a substantially higher computational effort. With the help of the strong deflection limit, we present the most accurate semi-analyticalmore » calculation of these higher order contributions to the iron lines for Schwarzschild black holes. We show that two regimes exist depending on the inclination of the disk with respect to the line of sight. Many useful analytical formulae can be also derived in this framework.« less

West Nile Virus and wildlife

USGS Publications Warehouse

Marra, P.P.; Griffing, S.; Caffrey, C.; Kilpatrick, A.M.; McLean, R.; Brand, C.; Saito, E.; Dupuis, A.P.; Kramer, Laura; Novak, R.

2004-01-01

West Nile virus (WNV) has spread rapidly across North America, resulting in human deaths and in the deaths of untold numbers of birds, mammals, and reptiles. The virus has reached Central America and the Caribbean and may spread to Hawaii and South America. Although tens of thousands of birds have died, and studies of some bird species show local declines, few regionwide declines can be attributed to WNV. Predicting future impacts of WNV on wildlife, and pinpointing what drives epidemics, will require substantial additional research into host susceptibility, reservoir competency, and linkages between climate, mosquitoes, and disease. Such work will entail a collaborative effort between scientists in governmental research groups, in surveillance and control programs, and in nongovernmental organizations. West Nile virus was not the first, and it will not be the last, exotic disease to be introduced to the New World. Its spread in North America highlights the need to strengthen animal monitoring programs and to integrate them with research on disease ecology.

Experimental Evaluation and Comparison of Thermal Conductivity of High-Voltage Insulation Materials for Vacuum Electronic Devices

NASA Astrophysics Data System (ADS)

Suresh, C.; Srikrishna, P.

2017-07-01

Vacuum electronic devices operate with very high voltage differences between their sub-assemblies which are separated by very small distances. These devices also emit large amounts of heat that needs to be dissipated. Hence, there exists a requirement for high-voltage insulators with good thermal conductivity for voltage isolation and efficient heat dissipation. However, these voltage insulators are generally poor conductors of heat. In the present work, an effort has been made to obtain good high-voltage insulation materials with substantial improvement in their thermal conductivity. New mixtures of composites were formed by blending varying percentages (by volumes) of aluminum nitride powders with that of neat room-temperature vulcanizing (RTV) silicone elastomer compound. In this work, a thermal conductivity test setup has been devised for the quantification of the thermal conductivity of the insulators. The thermal conductivities and high-voltage isolation capabilities of various blended composites were quantified and were compared with that of neat RTV to evaluate the relative improvement.

Paris Agreement climate proposals need a boost to keep warming well below 2 °C.

PubMed

Rogelj, Joeri; den Elzen, Michel; Höhne, Niklas; Fransen, Taryn; Fekete, Hanna; Winkler, Harald; Schaeffer, Roberto; Sha, Fu; Riahi, Keywan; Meinshausen, Malte

2016-06-30

The Paris climate agreement aims at holding global warming to well below 2 degrees Celsius and to "pursue efforts" to limit it to 1.5 degrees Celsius. To accomplish this, countries have submitted Intended Nationally Determined Contributions (INDCs) outlining their post-2020 climate action. Here we assess the effect of current INDCs on reducing aggregate greenhouse gas emissions, its implications for achieving the temperature objective of the Paris climate agreement, and potential options for overachievement. The INDCs collectively lower greenhouse gas emissions compared to where current policies stand, but still imply a median warming of 2.6-3.1 degrees Celsius by 2100. More can be achieved, because the agreement stipulates that targets for reducing greenhouse gas emissions are strengthened over time, both in ambition and scope. Substantial enhancement or over-delivery on current INDCs by additional national, sub-national and non-state actions is required to maintain a reasonable chance of meeting the target of keeping warming well below 2 degrees Celsius.

Bibliographic control of audiovisuals: analysis of a cataloging project using OCLC.

PubMed

Curtis, J A; Davison, F M

1985-04-01

The staff of the Quillen-Dishner College of Medicine Library cataloged 702 audiovisual titles between July 1, 1982, and June 30, 1983, using the OCLC database. This paper discusses the library's audiovisual collection and describes the method and scope of a study conducted during this project, the cataloging standards and conventions adopted, the assignment and use of NLM classification, the provision of summaries for programs, and the amount of staff time expended in cataloging typical items. An analysis of the use of OCLC for this project resulted in the following findings: the rate of successful searches for audiovisual copy was 82.4%; the error rate for records used was 41.9%; modifications were required in every record used; the Library of Congress and seven member institutions provided 62.8% of the records used. It was concluded that the effort to establish bibliographic control of audiovisuals is not widespread and that expanded and improved audiovisual cataloging by the Library of Congress and the National Library of Medicine would substantially contribute to that goal.

The value of trauma registries.

PubMed

Moore, Lynne; Clark, David E

2008-06-01

Trauma registries are databases that document acute care delivered to patients hospitalised with injuries. They are designed to provide information that can be used to improve the efficiency and quality of trauma care. Indeed, the combination of trauma registry data at regional or national levels can produce very large databases that allow unprecedented opportunities for the evaluation of patient outcomes and inter-hospital comparisons. However, the creation and upkeep of trauma registries requires a substantial investment of money, time and effort, data quality is an important challenge and aggregated trauma data sets rarely represent a population-based sample of trauma. In addition, trauma hospitalisations are already routinely documented in administrative hospital discharge databases. The present review aims to provide evidence that trauma registry data can be used to improve the care dispensed to victims of injury in ways that could not be achieved with information from administrative databases alone. In addition, we will define the structure and purpose of contemporary trauma registries, acknowledge their limitations, and discuss possible ways to make them more useful.

Biological contributions to addictions in adolescents and adults: prevention, treatment, and policy implications.

PubMed

Potenza, Marc N

2013-02-01

Despite significant advances in our understanding of the biological bases of addictions, these disorders continue to represent a huge public health burden that is associated with substantial personal suffering. Efforts to target addictions require consideration of how the improved biological understanding of addictions may lead to improved prevention, treatment, and policy initiatives. In this article, we provide a narrative review of current biological models for addictions with a goal of placing existing data and theories within a translational and developmental framework targeting the advancement of prevention, treatment, and policy strategies. Data regarding individual differences, intermediary phenotypes, and main and interactive influences of genetic and environmental contributions in the setting of developmental trajectories that may be influenced by addictive drugs or behavior indicate complex underpinnings of addictions. Consideration and further elucidation of the biological etiologies of addictions hold significant potential for making important gains and reducing the public health impact of addictions. Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Biological Contributions to Addictions in Adolescents and Adults: Prevention, Treatment and Policy Implications

PubMed Central

Potenza, Marc N.

2012-01-01

Purpose Despite significant advances in our understanding of the biological bases of addictions, these disorders continue to represent a huge public health burden that is associated with substantial personal suffering. Efforts to target addictions require consideration of how the improved biological understanding of addictions may lead to improved prevention, treatment and policy initiatives. Method In this article, we provide a narrative review of current biological models for addictions with a goal of placing existing data and theories within a translational and developmental framework targeting the advancement of prevention, treatment and policy strategies. Results Data regarding individual differences, intermediary phenotypes, and main and interactive influences of genetic and environmental contributions in the setting of developmental trajectories that may be influenced by addictive drugs or behavior indicate complex underpinnings of addictions. Conclusions Consideration and further elucidation of the biological etiologies of addictions hold significant potential for making important gains and reducing the public health impact of addictions. PMID:23332567