Science.gov

Sample records for requirements doe order

  1. Integrating total quality management principles with the requirements of DOE Order 5700.6C

    SciTech Connect

    Hedges, D.

    1993-03-01

    The Department of Energy has recently required its field offices, contractors, and subcontractors to implement DOE Order 5700.6C, ``Quality Assurance,`` for all work on waste management contracts. The order restructures the 18 criteria of NQA-1 and focuses on the role of management in achieving and assuring quality, performance of activities to achieve and assure quality, and management`s assessment of its performance for the purpose of identifying improvements to be made. The DOE order also introduces elements of the total quality management (TQM) philosophy, which were not present in DOE Order 5700.6B. The research community within DOE has recently issued a document entitled DOE Order 5700.6C Implementation Guide, which is more explicit about the integration of TQM principles with the implementation of DOE Order 5700.6C in research facilities. The Environmental Protection Agency is sponsoring a quality assurance standard (ANSI/ASQC E-4) to replace EPA`s QAMS 005/80. The new standard is consistent with DOE Order 5700.6C, and it also stresses the integration of TQM principles within the quality assurance process. This paper discusses the intent and philosophy of the 10 criteria of the new DOE order, the status of ANSI/ASQC E-4, and how to effectively integrate TQM principles into the quality assurance process as the conversion is made from NQA-1 to DOE Order 5700.6C. The purpose and value of DOE Order 5700.6C Implementation Guide for research will also be discussed.

  2. Exemptions form PSD Permit Requirements for Coal Conversions Resulting from DOE Prohibition Orders

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  3. 1994 annual report on waste generation and waste minimization progress as required by DOE Order 5400.1

    SciTech Connect

    Irwin, E.F.; Poligone, S.E.

    1995-10-16

    The Y-12 Plant serves as a key manufacturing technology center for the development and demonstration of unique materials, components, and services of importance to the Department of Energy (DOE) and the nation. This is accomplished through the reclamation and storage of nuclear materials, manufacture of nuclear materials, manufacture of components for the nation`s defense capabilities, support to national security programs, and services provided to other customers as approved by DOE. We are recognized by our people, the community, and our customers as innovative, responsive, and responsible. We are a leader in worker health and safety, environmental protection, and stewardship of our national resources. As a DOE facility, Y-12 also supports DOE`s waste minimization mission. Data contained in this report represents waste generation in Tennessee.

  4. Does Methanogenesis Require Oxygen?

    NASA Astrophysics Data System (ADS)

    Shoemaker, J. K.; Schrag, D. P.

    2011-12-01

    Despite the importance of methane biogeochemistry to climate studies, a mechanistic understanding of what controls methane production and emissions from natural sources is still lacking. Using an isotope mass balance of the CO2 dissolved in the pore waters at Sallie's Fen, a New Hampshire wetland, we find that the carbon isotopes from the pore waters do not account for the methane emissions observed from this site. In order to try and close the isotope mass balance, we sampled gases from the unsaturated peat at the same location multiple times throughout a summer season. We found a subset of the gas samples to contain high concentrations of CO2 with very enriched carbon isotopic signatures. Such a signal can only be explained by a signficiant contribution of methanogenic CO2 to these samples, which would not occur if this methane was produced deep within the pore waters. The transport of CO2 in wetland pore waters, unlike methane, is dominated by diffusion. For this reason, the CO2 produced as a biproduct of subsurface methanogenesis emerges slowly from the pore waters and the isotopic signal would be masked by respiration, which is the dominant source of CO2 flux. Instead, these samples indicate a potentially large, but unquantified, source of methane from either the surface pore water or the unsaturated peat. Although archael methane producers are obligately anaerobic, they rely on a cascade of both anaerobic and aerobic processes for providing available carbon substrates. We suggest that the primary factor limiting both fermentation and methane production in terrestrial soils is a lack of substrate supply from oxic processes. More specifically, methanogenesis in terrestrial soils may be constrained by the same step that limits bulk organic matter degradation in saturated soils - the activity of oxic exoenzymes that break down complex organic material such that it is available to microbial degraders. This results in the majority of methane production occurring at

  5. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under...

  6. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under Service...

  7. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under Service...

  8. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false What this order does. Section 1 Section 1 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY BONDING OF SHIP'S PERSONNEL Section 1 What this order does. This order requires that General Agents, appointed under Service...

  9. Quality Assurance Grading Guidelines for Research and Development at DOE Facilities (DOE Order 5700.6C)

    SciTech Connect

    Powell, T.B.

    1992-01-01

    The quality assurance (QA) requirements for the U.S. Department of Energy (DOE) are established in DOE Order 5700.6C. This order is applicable for all DOE departmental elements, management, and maintenance and operating contractors and requires that documented Quality Assurance Programs (QAPs) are prepared at all levels; it has one attachment. The DOE Office of Energy Research (DOE-ER) has issued a standard to ensure implementation of the full intent of this order in the ER community.

  10. A PROPOSED FRAMEWORK FOR PLANNING DEACTIVATION AND DECOMMISSIONING ENGINEERING AND DESIGN ACTIVITIES TO MEET THE REQUIREMENTS OF DOE ORDER 413.3A, PROGRAM AND PROJECT MANAGEMENT FOR THE ACQUISITION OF CAPITAL ASSETS

    SciTech Connect

    Santos, J; John Gladden, J

    2007-11-06

    This paper provides guidance in applying the requirements of DOE O 413.3A to Deactivation and Decommissioning (D&D) projects. A list of 41 engineering and design activities relevant to D&D projects was generated. For several activities in this list, examples of the level of development and/or types of deliverables that might be expected at the completion of the conceptual, preliminary and final project design phases described in the Order are provided.

  11. Policy Perspective: Meeting the Challenge of the DOE Order 436.1 Departmental Sustainability - 12527

    SciTech Connect

    MacDonald, Jennifer C.

    2012-07-01

    DOE's Sustainability Performance Office is working to meet sustainability goals at DOE by implementing Executive Orders, Departmental policy, the DOE Strategic Sustainability Performance Plan (SSPP) and legislation related to sustainability. Through implementation of Executive Orders, Departmental policy, the SSPP, statutory requirements and regular reporting, analysis and communication, DOE's SPO is working to maintain and expand DOE's leadership in sustainability. (authors)

  12. Does aging change nutrition requirements?

    PubMed

    Drewnowski, A; Warren-Mears, V A

    2001-01-01

    The current adult guidelines for a healthy diet make no distinctions between adults aged 25-50 y and those aged 51 y and over. The question is whether dietary guidelines ought to be stratified by age, in recognition of the dietary and nutrient needs of the growing population of elderly adults. There are limited data on nutrient requirements of older adults. Aging is accompanied by a variety of physiological, psychological, economic and social changes that may adversely affect nutritional status. Older people have a higher prevalence of chronic disease, take multiple medications and supplements, and tend to be sedentary. Higher prevalence of obesity is difficult to reconcile with sharply lowered energy intakes. While basal metabolic rate does decline with age, lack of physical activity among the elderly is the more likely answer. The USDA Food Guide Pyramid is the key tool for communicating dietary advice to consumers. Researchers at Tufts University have produced a 70+ pyramid to reflect the nutrient needs of elderly adults. An additional focus has been on quality of life issues. Increased longevity is not always associated with continued good health. The Healthy People 2010 Objectives now use quality of life as a national health standard. Whereas health related quality of life (HRQOL) measures assess physical and mental health and their determinants, global quality of life measures focus on life satisfaction. Optimal nutrition promotes both functional health status and mental well-being. Dietary diversity and variety promotes enjoyment and satisfaction with the diet. Regular physical activity promotes strength and endurance, helps to maintain appropriate body weight, and contributes to independent physical functioning. Improving health-related quality of life is a key element in promoting the health and well-being of older adults.

  13. Quality assurance grading guidelines for research and development at DOE facilities. DOE Order 5700.6C

    SciTech Connect

    Powell, T.B.; Morris, R.N.

    1992-10-01

    The quality assurance (QA) requirements for the US Department of Energy (DOE) are established in DOE Order 5700.6C. This order is applicable for all DOE departmental elements, management, and maintenance and operating contractors and requires that documented Quality Assurance Programs (QAPS) are prepared at all levels; it has one attachment. The DOE Office of Energy Research (DOE-ER) has issued a standard to ensure implementation of the full intent of this order in the ER community. This report discusses order 5700.6C in relation to research with DOE.

  14. Does Presentation Order Impact Choice After Delay?

    PubMed

    Berger, Jonah

    2016-07-01

    Options are often presented incidentally in a sequence, but does serial position impact choice after delay, and if so, how? We address this question in a consequential real-world choice domain. Using 25 years of citation data, and a unique identification strategy, we examine the relationship between article order (i.e., position in a journal issue) and citation count. Results indicate that mere serial position affects the prominence that research achieves: Earlier-listed articles receive more citations. Furthermore, our identification strategy allows us to cast doubt on alternative explanations (i.e., editorial placement) and instead indicate that the effect is driven by psychological processes of attention and memory. These findings deepen the understanding of how presentation order impacts choice, suggest that subtle presentation factors can bias an important scientific metric, and shed light on how psychological processes shape collective outcomes.

  15. Review of orders and regulations requiring environmental protection

    SciTech Connect

    Kelly, E.; Cunningham, R.; Michael, D.

    1996-09-01

    With the increased awareness of and interest in potential ecological risks associated with past, current, and future Department of Energy (DOE) activities, DOE`s Defense Programs (DP) Office of Technical and Environmental Support sponsored a study to (1) evaluate the effectiveness of the current compliance-driven environmental protection and assessment efforts relative to ecological concerns; (2) explore the need for a more focused, integrated approach to address ecological impacts; and (3) identify the requirements for an integrated approach. The study explored four questions. (a) Which federal regulations and DOE orders either explicitly require ecological assessments or implicitly require them through environmental protection language? (b) What currently is being done at selected DOE facilities to implement these regulations and orders? (c) What are private sector industries doing in terms of ecological risk assessments and how do industry approaches and issues compare with those of DOE? (d) What, if anything, in addition to current efforts is needed to ensure the protection of ecological resources associated with DOE facilities, to support defensible decision making, and to improve efficiency? The results of this study are presented in a report titled {open_quotes}Integrated, Comprehensive Ecological Impact Assessments In Support of Department of Energy Decision Making{close_quotes}. This report is a companion document to that report. This report provides a more detailed discussion of the document reviews of the relevant environmental protection regulations and current and pending DOE orders. The main goal of the document reviews was to understand existing requirements for ecological data collection and impact assessments.

  16. Simulation Higher Order Language Requirements Study.

    ERIC Educational Resources Information Center

    Goodenough, John B.; Braun, Christine L.

    The definitions provided for high order language (HOL) requirements for programming flight training simulators are based on the analysis of programs written for a variety of simulators. Examples drawn from these programs are used to justify the need for certain HOL capabilities. A description of the general structure and organization of the…

  17. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP individual...

  18. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP individual...

  19. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP individual...

  20. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP individual...

  1. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ACCOMPLISHMENT OF SHIP REPAIRS UNDER NATIONAL SHIPPING AUTHORITY INDIVIDUAL CONTRACT FOR MINOR REPAIRS-NSA-WORKSMALREP Section 1 What this order does. This order authorizes the use of NSA-WORKSMALREP individual...

  2. ALTHOUGH SOUTHERN DUCTILE DOES NOT OWN PATTERNS, THEY ARE REQUIRED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ALTHOUGH SOUTHERN DUCTILE DOES NOT OWN PATTERNS, THEY ARE REQUIRED TO STORE THEM AND KEEP THEM AVAILABLE FOR THEIR CUSTOMERS ORDERS. THE BARRET/DOUGLAS LIFTING TRUCK IS USED TO REACH AND TRANSPORT PATTERNS. - Southern Ductile Casting Company, Mold Making, 2217 Carolina Avenue, Bessemer, Jefferson County, AL

  3. Impact assessment of draft DOE Order 5820.2B. Radioactive Waste Technical Support Program

    SciTech Connect

    1995-04-01

    The Department of Energy (DOE) has prepared a revision to DOE Order 5820.2A, entitled ``Radioactive Waste Management.`` DOE issued DOE Order 5820.2A in September 1988 and, as the title implies, it covered only radioactive waste forms. The proposed draft order, entitled ``Waste Management,`` addresses the management of both radioactive and nonradioactive waste forms. It also includes spent nuclear fuel, which DOE does not consider a waste. Waste forms covered include hazardous waste, high-level waste, transuranic (TRU) waste, low-level radioactive waste, uranium and thorium mill tailings, mixed waste, and sanitary waste. The Radioactive Waste Technical Support Program (TSP) of Leached Idaho Technologies Company (LITCO) is facilitating the revision of this order. The EM Regulatory Compliance Division (EM-331) has requested that TSP estimate the impacts and costs of compliance with the revised order. TSP requested Dames & Moore to aid in this assessment by comparing requirements in Draft Order 5820.2B to ones in DOE Order 5820.2A and other DOE orders and Federal regulations. The assessment started with a draft version of 5820.2B dated January 14, 1994. DOE has released three updated versions of the draft order since then (dated May 20, 1994; August 26, 1994; and January 23, 1995). Each time DOE revised the order, Dames and Moore updated the assessment work to reflect the text changes. This report reflects the January 23, 1995 version of the draft order.

  4. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure to... repairs under the National Shipping Authority Master Repair Contract, NSA-LUMPSUMREP. The Coast Directors...

  5. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure to... repairs under the National Shipping Authority Master Repair Contract, NSA-LUMPSUMREP. The Coast Directors...

  6. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure to... repairs under the National Shipping Authority Master Repair Contract, NSA-LUMPSUMREP. The Coast Directors...

  7. 46 CFR Section 1 - What this order does.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Section 1 What this order does. This order cancels NSA Order No. 32 (SRM-1); and outlines the procedure to... repairs under the National Shipping Authority Master Repair Contract, NSA-LUMPSUMREP. The Coast Directors...

  8. Does gingival recession require surgical treatment?

    PubMed Central

    Chan, Hsun-Liang; Chun, Yong-Hee Patricia; MacEachern, Mark

    2016-01-01

    Gingival recession represents a clinical condition in adults frequently encountered in the general dental practice. It is estimated that 23% of adults in the US have one or more tooth surfaces with ≥ 3 mm gingival recession. Clinicians often time face dilemmas of whether or not to treat such a condition surgically. Therefore, we were charged by the editorial board to answer this critical question: “Does gingival recession require surgical treatment?” An initial condensed literature search was performed using a combination of gingival recession and surgery controlled terms and keywords. An analysis of the search results highlights our limited understanding of the factors that often guide the treatment of gingival recession. Understanding the etiology, prognosis and treatment of gingival recession continues to offer many unanswered questions and challenges in the field of periodontics as we strive to provide the best care possible for our patients. PMID:26427577

  9. Planned revision to DOE Order 5820.2A, Radioactive Waste Management

    SciTech Connect

    Duggan, G.J.; Williams, R.E.; Kudera, D.E.; Bailey, D.E.

    1993-03-01

    US Department of Energy Headquarters initiated efforts to revise DOE Order 5820.2A, ``Radioactive Waste Management``. The purpose of the revision is to enhance DOE waste management requirements, reflect new DOE organizational responsibilities, and consolidate requirements for management of all waste, under the responsibility of Environmental Restoration and Waste Management, into a single order. This paper discusses the revision philosophy, objectives of the revision, and strategy for the revision. Issues being considered for inclusion in the revision and recommended methods of resolving each issue are also discussed.

  10. Fluor Daniel Hanford implementation plan for DOE Order 5480.28, Natural phenomena hazards mitigation

    SciTech Connect

    Conrads, T.J.

    1997-09-12

    Natural phenomena hazards (NPH) are unexpected acts of nature that pose a threat or danger to workers, the public, or the environment. Earthquakes, extreme winds (hurricane and tornado), snow, flooding, volcanic ashfall, and lightning strikes are examples of NPH that could occur at the Hanford Site. U.S. Department of Energy (DOE) policy requires facilities to be designed, constructed, and operated in a manner that protects workers, the public, and the environment from hazards caused by natural phenomena. DOE Order 5480.28, Natural Phenomena Hazards Mitigation, includes rigorous new natural phenomena criteria for the design of new DOE facilities, as well as for the evaluation and, if necessary, upgrade of existing DOE facilities. The Order was transmitted to Westinghouse Hanford Company in 1993 for compliance and is also identified in the Project Hanford Management Contract, Section J, Appendix C. Criteria and requirements of DOE Order 5480.28 are included in five standards, the last of which, DOE-STD-1023, was released in fiscal year 1996. Because the Order was released before all of its required standards were released, enforcement of the Order was waived pending release of the last standard and determination of an in-force date by DOE Richland Operations Office (DOE-RL). Agreement also was reached between the Management and Operations Contractor and DOE-RL that the Order would become enforceable for new structures, systems, and components (SSCS) 60 days following issue of a new order-based design criteria in HNF-PRO-97, Engineering Design and Evaluation. The order also requires that commitments addressing existing SSCs be included in an implementation plan that is to be issued 1 year following the release of the last standard. Subsequently, WHC-SP-1175, Westinghouse Hanford Company Implementation Plan for DOE Order 5480.28, Natural Phenomena Hazards Mitigation, Rev. 0, was issued in November 1996, and this document, HNF-SP-1175, Fluor Daniel Hanford

  11. DOE Order 5480.28 Hanford facilities database

    SciTech Connect

    Hayenga, J.L., Westinghouse Hanford

    1996-09-01

    This document describes the development of a database of DOE and/or leased Hanford Site Facilities. The completed database will consist of structure/facility parameters essential to the prioritization of these structures for natural phenomena hazard vulnerability in compliance with DOE Order 5480.28, `Natural Phenomena Hazards Mitigation`. The prioritization process will be based upon the structure/facility vulnerability to natural phenomena hazards. The ACCESS based database, `Hanford Facilities Site Database`, is generated from current Hanford Site information and databases.

  12. 40 CFR 141.503 - What does subpart T require?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false What does subpart T require? 141.503 Section 141.503 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... Fewer Than 10,000 People General Requirements § 141.503 What does subpart T require? There are...

  13. DOE Order 5820.2A implementation status, progress and problems

    SciTech Connect

    Waldo, L.C.; Shepard, M.D.; Wilhite, E.L.

    1989-11-01

    The Department of Energy`s Order governing management of radioactive waste, DOE Order 5820.2A, was revised effective September 26, 1988. Chapter III of the Order contains prescriptive requirements for managing low-level waste. These requirements ensure that all DOE low-level radioactive and mixed waste will be managed in a systematic manner to achieve required performance., The Order defines performance objectives for low-level waste management to limit the dose received by the general public from waste operations, to protect groundwater resources, and to protect inadvertent intruders. For low-level waste disposal operations, the Order requires that a radiological performance assessment be prepared to demonstrate compliance with the performance objectives. The Order also requires that the radiological performance assessments be reviewed by a Peer Review Panel, established by the Order. This paper will summarize the requirements for radioactive waste management and discuss the degree of compliance achieved to date. The Department`s preliminary schedule and anticipated cost to achieve full compliance with the requirements will also be discussed.

  14. 21 CFR 1305.21 - Requirements for electronic orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Requirements for electronic orders. 1305.21... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.21 Requirements for electronic orders. (a) To be valid, the purchaser must sign an electronic order for a Schedule I or II controlled substance...

  15. 21 CFR 1305.21 - Requirements for electronic orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Requirements for electronic orders. 1305.21... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.21 Requirements for electronic orders. (a) To be valid, the purchaser must sign an electronic order for a Schedule I or II controlled substance...

  16. Bacterial growth does require peptidoglycan hydrolases.

    PubMed

    Vollmer, Waldemar

    2012-12-01

    Most bacteria surround their cytoplasmic membrane with a net-like, elastic heteropolymer, the peptidoglycan sacculus, to protect themselves from bursting due to the turgor and to maintain cell shape. It has been assumed that growing bacteria require peptidoglycan hydrolases to open meshes in the peptidoglycan net allowing the insertion of the newly synthesized material for surface expansion. However, peptidoglycan hydrolases essential for bacterial growth have long remained elusive. In this issue of Molecular Microbiology Singh et al. (2012) report the identification in Escherichia coli of three new DD-endopeptidases (Spr, YdhO and YebA) which are collectively required for peptidoglycan growth. Cells depleted of the three enzymes fail to incorporate new peptidoglycan, indicating that the cleavage of cross-links by the new endopeptidases is needed for surface growth of the sacculus. These results are corroborated by recent data showing that Bacillus subtilis cells require the DL-endopeptidase activity of CwlO or LytE for growth.

  17. Does the isolation effect require attention?

    PubMed

    Bireta, Tamra J; Mazzei, Colleen M

    2016-01-01

    An item that differs from the surrounding items is remembered better than an item that is consistent with its surroundings; this is known as the von Restorff effect or isolation effect (von Restorff, Psychologische Forschung, 18, 299-342, 1933). Theoretical explanations have proposed that the isolate is processed differently from control items, though some research has suggested that this processing might require more attention for semantic than for physical isolates. To test this possibility, in the present study we examined the isolation effects for physical isolates and semantic isolates under full and divided attention. Participants viewed lists of categorized words, with some lists containing either a physical or a semantic isolate, followed by immediate written free recall. Across three experiments, divided attention eliminated the semantic isolation effect but did not impact the physical isolation effect. Furthermore, semantic isolates were output earlier in recall than controls, whereas physical isolates were output more similarly to controls. These findings suggest that semantic isolation effects require attention during encoding, whereas physical isolation effects are relatively automatic.

  18. Does perceptual learning require consciousness or attention?

    PubMed

    Meuwese, Julia D I; Post, Ruben A G; Scholte, H Steven; Lamme, Victor A F

    2013-10-01

    , suggesting that the memory trace that is formed during inattention is latent until accessed. The results suggest that learning requires consciousness, and not attention, and further strengthen the idea that consciousness is separate from attention.

  19. 2006 Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    Michael G. Lewis

    2007-09-01

    In accordance with Contract Data Requirements List F.19, this report addresses the Best Available Technology requirements per Department of Energy (DOE) Order 5400.5, “Radiation Protection of the Public and the Environment,” as they apply to radiological discharges to the soil for Calendar Year 2006. The report includes review of discharges for both, Battelle Energy Alliance, LLC and CH2M WG Idaho, LLC. The Best Available Technology selection process is applicable to wastewater discharges containing process derived radionuclides to surface waters, sanitary sewerages greater than five times the Derived Concentration Guideline (found in DOE Order 5400.5), and to the soil. Wastewater at the Idaho National Laboratory Site is not discharged to surface water (Big Lost River and Birch Creek) nor is it discharged to sanitary sewerages at activity levels greater than five times a Derived Concentration Guideline. Therefore, this report focuses on radiological discharges to the soil.

  20. Assessment of documentation requirements under DOE 5481. 1, Safety Analysis and Review System (SARS)

    SciTech Connect

    Browne, E.T.

    1981-03-01

    This report assesses the requirements of DOE Order 5481.1, Safety Analysis and Review System for DOE Operations (SARS) in regard to maintaining SARS documentation. Under SARS, all pertinent details of the entire safety analysis and review process for each DOE operation are to be traceable from the initial identification of a hazard. This report is intended to provide assistance in identifying the points in the SARS cycle at which documentation is required, what type of documentation is most appropriate, and where it ultimately should be maintained.

  1. 21 CFR 20.83 - Disclosure required by court order.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20.83 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PUBLIC INFORMATION Limitations on Exemptions § 20.83 Disclosure required by court order. (a) Records of.... (b) Where the Food and Drug Administration record ordered disclosed under paragraph (a) of this...

  2. 21 CFR 20.83 - Disclosure required by court order.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20.83 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PUBLIC INFORMATION Limitations on Exemptions § 20.83 Disclosure required by court order. (a) Records of.... (b) Where the Food and Drug Administration record ordered disclosed under paragraph (a) of this...

  3. 21 CFR 20.83 - Disclosure required by court order.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20.83 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PUBLIC INFORMATION Limitations on Exemptions § 20.83 Disclosure required by court order. (a) Records of.... (b) Where the Food and Drug Administration record ordered disclosed under paragraph (a) of this...

  4. 2005 Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    INL

    2006-09-01

    The report addresses Best Available Technology per DOE Order 5400.5 in relation to wastewater discharges to the soil. In accordance with Contract Data Requirements List F.19, this report addresses the Best Available Technology requirements per Department of Energy (DOE) Order 5400.5, "Radiation Protection of the Public and the Environment", as they apply to radiological discharges to the soil for Calendar Year 2005. The report includes review of discharges for both, Battelle Energy Alliance, LLC and CH2M WG Idaho, LLC. The Best Available Technology selection process is applicable to wastewater discharges containing process derived radionuclides to surface waters, sanitary sewerages greater than five times the Derived Concentration Guideline (found in DOE Order 5400.5), and to the soil. Wastewater at the Idaho National Laboratory Site is not discharged to surface water (Big Lost River and Birch Creek) nor is it discharged to sanitary sewerages at activity levels greater than five times a Derived Concentration Guideline. Therefore, this report focuses on radiological discharges to the soil.

  5. CERCLA reporting requirements, DOE occurrence reporting, and the DOE Emergency Management System. CERCLA Information Brief

    SciTech Connect

    Dailey, R.

    1993-10-01

    The Emergency Management System (EMS) provides a structure for reporting and processing operations information related to DOE owned/operated facilities. Hazardous Substance (HS) releases are subject to reporting requirements under the EMS as well as under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). CERCLA requires reporting of HS releases into the environment in amounts greater than or equal to Reportable Quantities (RQs). This Information Brief elaborates on earlier CERCLA reporting and response process information Briefs by providing a general explanation of these CERCLA or EMS requirements, procedures, and events as they pertain to releases of HS`s at DOE facilities.

  6. Role Sequencing: Does Order Matter for Mental Health?

    ERIC Educational Resources Information Center

    Jackson, Pamela Braboy

    2004-01-01

    Role sequencing refers to the ordering of social roles. According to the normative order hypothesis, adults who follow a certain sequencing of their social roles will be better adjusted than their peers who follow other life course patterns. The normative order is defined as first entering the paid labor force, getting married, and later having…

  7. 16 CFR 2.11 - Orders requiring access.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE NONADJUDICATIVE PROCEDURES Inquiries; Investigations; Compulsory Processes § 2.11 Orders requiring access. (a) In investigations other than those conducted under section 20 of the Federal Trade Commission Act, the...

  8. 16 CFR 2.11 - Orders requiring access.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE NONADJUDICATIVE PROCEDURES Inquiries; Investigations; Compulsory Processes § 2.11 Orders requiring access. (a) In investigations other than those conducted under section 20 of the Federal Trade Commission Act, the...

  9. Status Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    Lewis, Michael George

    2001-09-01

    This report documents the Bechtel BWXT Idaho, LCC, operated facilities at the Idaho National Engineering and Environmental Laboratory that require the Best Available Technology selection process in accordance with Department of Energy Order 5400.5, Chapter II (3), “Management and Control of Radioactive Materials in Liquid Discharges.”1 This report differs from previous reports in that only those liquid waste streams and facilities requiring the Best Available Technology selection process will be evaluated in detail. In addition, this report will be submitted to the DOE-ID Field Office Manager for approval in accordance with DOE Order 5400.5, Chapter II, Section 3.b.(1). The report also identifies facilities addressed in last year’s report that do not require the Best Available Technology selection process to be completed. These facilities will not be addressed in future reports. This report reviews the following facilities: • Auxiliary Reactor Area • Idaho National Engineering and Environmental Laboratory Block Areas • Central Facilities Area • Idaho Nuclear Technology and Engineering Center • Idaho Falls Facilities • Power Burst Facility • Radioactive Waste Management Complex • Test Area North • Test Reactor Area. Three facilities (Central Facilities Area Sewage Treatment Plant, Idaho Nuclear Technology and Engineering Center Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the Best Available Technology selection process. The Idaho Nuclear Technology and Engineering Center Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond discharge wastewater that may contain process-derived radionuclides to a soil column with average radionuclide concentrations below drinking water MCLs. At the request of the Department of Energy Idaho Operations Office, Bechtel BWXT Idaho, LLC has included the 73.5acre

  10. Does the Answer Order Matter on Multiple-Choice Exams?

    ERIC Educational Resources Information Center

    Tellinghuisen, Joel; Sulikowski, Michelle M.

    2008-01-01

    Surprising version-dependent differences are noted in student performance on certain questions in a standardized general chemistry exam. The exam in question has two versions, on which both questions and answers are ordered differently. For the questions suspected of answer-order bias, the performance is better in ten of twelve cases when students…

  11. 21 CFR 1.378 - What criteria does FDA use to order a detention?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false What criteria does FDA use to order a detention? 1... General Provisions § 1.378 What criteria does FDA use to order a detention? An officer or qualified employee of FDA may order the detention of any article of food that is found during an...

  12. Report on inspection of compliance with DOE Order 2030.4B at the Savannah River Site

    SciTech Connect

    1997-03-01

    The purpose of this inspection was to evaluate contractor compliance at the Savannah River Site (SRS) with Department of Energy (DOE) Order 2030.4B, {open_quotes}Reporting Fraud, Waste, And Abuse To The Office Of Inspector General.{close_quotes} The specific objective was to determine if the SRS management and operating (M&O) contractors were complying with the requirements in Paragraph 6.c. of DOE Order 2030.4B. These requirements are: (1) annual notification to employees of their duty to report allegations of fraud, waste, abuse, corruption, or mismanagement; (2) display and publish the DOE Office of Inspector General (OIG) Hotline telephone number in common areas of buildings; (3) display and publish the DOE OIG Hotline number in telephone books and newsletters; and (4) notify the OIG cases referred to other law enforcement entities.

  13. Status Update for Implementing Best Available Technology per DOE Order 5400.5 (2003)

    SciTech Connect

    Michael Lewis

    2004-09-01

    This report identifies discharges of liquid waste streams that require documentation of the best available technology selection process at Bechtel BWXT Idaho, LLC, operated facilities at the Idaho National Engineering and Environmental Laboratory. The best available technology selection process is conducted according to Department of Energy Order 5400.5, Chapter II (3), “Management and Control of Radioactive Materials in Liquid Discharges and Phaseout of Soil Columns” and Department of Energy guidance. This report evaluates only those liquid waste streams and facilities where the best available technology selection process was determined to apply. Two facilities (Idaho Nuclear Technology and Engineering Center New Percolation Ponds and Test Area North/Technical Support Facility Sewage Treatment Plant Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the best available technology selection process. These two facilities required documentation of the best available technology selection process because they discharge wastewater that may contain process-derived radionuclides to a soil column even though the average radioactivity levels are typically below drinking water maximum contaminant levels. At the request of the Department of Energy Idaho Operations Office, the 73.5-acre Central Facilities Area Sewage Treatment Plant land application site is included in this report to ensure the requirements of DOE Order 5400.5, Chapter II, Section 3 are met. The Central Facilities Area Sewage Treatment Plant effluent contains process-derived radionuclides from radioactive tracers used in certain analytical procedures. The radioactivity levels of these radionuclides are below maximum contaminant levels. The Department of Energy Idaho Operations Office will submit this report to their field office manager for approval according to DOE Order 5400.5, Chapter II, Section 3.b.(1).

  14. Parent-Child Quality Time: Does Birth Order Matter?

    ERIC Educational Resources Information Center

    Price, Joseph

    2008-01-01

    Using data from the American Time Use Survey, I find that a first-born child receives 20-30 more minutes of quality time each day with his or her parent than a second-born child of the same age from a similar family. The birth-order difference results from parents giving roughly equal time to each child at any point in time while the amount of…

  15. Parent-Child Quality Time: Does Birth Order Matter?

    ERIC Educational Resources Information Center

    Price, Joseph

    2008-01-01

    Using data from the American Time Use Survey, I find that a first-born child receives 20-30 more minutes of quality time each day with his or her parent than a second-born child of the same age from a similar family. The birth-order difference results from parents giving roughly equal time to each child at any point in time while the amount of…

  16. 20 CFR 1002.290 - Does VETS have the authority to order compliance with USERRA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Does VETS have the authority to order... and Referral § 1002.290 Does VETS have the authority to order compliance with USERRA? No. If VETS determines as a result of an investigation that the complaint is meritorious, VETS attempts to resolve the...

  17. 20 CFR 1002.290 - Does VETS have the authority to order compliance with USERRA?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Does VETS have the authority to order... and Referral § 1002.290 Does VETS have the authority to order compliance with USERRA? No. If VETS determines as a result of an investigation that the complaint is meritorious, VETS attempts to resolve the...

  18. 20 CFR 1002.290 - Does VETS have the authority to order compliance with USERRA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Does VETS have the authority to order... and Referral § 1002.290 Does VETS have the authority to order compliance with USERRA? No. If VETS determines as a result of an investigation that the complaint is meritorious, VETS attempts to resolve the...

  19. 20 CFR 1002.290 - Does VETS have the authority to order compliance with USERRA?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Does VETS have the authority to order... and Referral § 1002.290 Does VETS have the authority to order compliance with USERRA? No. If VETS determines as a result of an investigation that the complaint is meritorious, VETS attempts to resolve the...

  20. 20 CFR 1002.290 - Does VETS have the authority to order compliance with USERRA?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Does VETS have the authority to order... and Referral § 1002.290 Does VETS have the authority to order compliance with USERRA? No. If VETS determines as a result of an investigation that the complaint is meritorious, VETS attempts to resolve the...

  1. Self-controlled KR schedules: does repetition order matter?

    PubMed

    Patterson, Jae T; Carter, Michael J; Hansen, Steve

    2013-08-01

    The impact of an experimenter-defined repetition schedule on the utility of a self-controlled KR context during motor skill acquisition was examined. Participants were required to learn three novel spatial-temporal tasks in either a random or blocked repetition schedule with or without the opportunity to control their KR. Results from the retention period showed that participants provided control over their KR schedule in a random repetition schedule demonstrated superior learning. However, performance measures from the transfer test showed that, independent of repetition schedule, learners provided the opportunity to control their KR schedule demonstrated superior transfer performance compared to their yoked counterparts. The dissociated impact of repetition schedule and self-controlled KR schedules on retention and transfer is discussed. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. IDENTIFICATION OF DOE'S POST-CLOSURE MONITORING NEEDS AND REQUIREMENTS

    SciTech Connect

    M.A. Ebadian, Ph.D.

    1999-01-01

    The 2006 plan sets an ambitious agenda for the U.S. Department of Energy (DOE), Office of Environmental Management (EM) and the remediation of sites contaminated by decades of nuclear weapons production activities. The plan's primary objective is to reduce overall clean up costs by first eliminating the environmental problems that are most expensive to control and safely maintain. In the context of the 2006 Plan, closure refers to the completion of area or facility specific cleanup projects. The cleanup levels are determined by the planned future use of the site or facility. Use restrictions are still undecided for most sites but are highly probable to exclude residential or agricultural activities. Most of the land will be remediated to ''industrial use'' levels with access restrictions and some areas will be closed-off through containment. Portions of the site will be reserved for waste disposal, either as a waste repository or the in-situ immobilization of contaminated soil and groundwater, and land use will be restricted to waste disposal only. The land used for waste disposal will require monitoring and maintenance activities after closure. Most of the land used for industrial use may also require such postclosure activities. The required postclosure monitoring and maintenance activities will be imposed by regulators and stakeholders. Regulators will not approve closure plans without clearly defined monitoring methods using approved technologies. Therefore, among all other more costly and labor-intensive closure-related activities, inadequate planning for monitoring and lack of appropriate monitoring technologies can prevent closure. The purpose of this project is to determine, document, and track the current and evolving postclosure monitoring requirements at DOE-EM sites. This information will aid CMST-CP in guiding its postclosure technology development and deployment efforts.

  3. Comparison of selected DOE and non-DOE requirements, standards, and practices for Low-Level Radioactive Waste Disposal

    SciTech Connect

    Cole, L.; Kudera, D.; Newberry, W.

    1995-12-01

    This document results from the Secretary of Energy`s response to Defense Nuclear Facilities Safety Board Recommendation 94--2. The Secretary stated that the US Department of Energy (DOE) would ``address such issues as...the need for additional requirements, standards, and guidance on low-level radioactive waste management. `` The authors gathered information and compared DOE requirements and standards for the safety aspects Of low-level disposal with similar requirements and standards of non-DOE entities.

  4. Status Update for Implementing Best Available Technology per DOE Order 5400.5 - September 2002

    SciTech Connect

    Lewis, Michael George

    2002-09-01

    This report identifies discharges of liquid waste streams that require documentation of the Best Available Technology selection process at Bechtel BWXT Idaho, LLC, operated facilities at the Idaho National Engineering and Environmental Laboratory. The Best Available Technology selection process is conducted according to Department of Energy Order 5400.5, Chapter II (3),“Management and Control of Radioactive Materials in Liquid Discharges and Phaseout of Soil Columns” and Department of Energy guidance. Only those liquid waste streams and facilities requiring the Best Available Technology selection process are evaluated in further detail. In addition, this report will be submitted to the Department of Energy Idaho Operations Office Field Office manager for approval according to DOE Order 5400.5, Chapter II, Section 3.b.(1). Two facilities (Idaho Nuclear Technology and Engineering Center existing Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the Best Available Technology selection process (Section 4). These two facilities required documentation of the Best Available Technology selection process because they discharge wastewater that may contain process-derived radionuclides to a soil column even though the average radioactivity levels are typically below drinking water maximum contaminant levels. At the request of the Department of Energy Idaho Operations Office, the 73.5-acre Central Facilities Area Sewage Treatment Plant land application site is included in Section 4 of this report to ensure the requirements of DOE Order 5400.5, Chapter II, Section 3 are met. The Central Facilities Area Sewage Treatment Plant effluent contains process-derived radionuclides from radioactive tracers used in certain analytical procedures. The radioactivity levels of these radionuclides are below maximum contaminant levels. According to Department of Energy

  5. Canister storage building compliance assessment DOE Order 6430.1A, General Design Criteria

    SciTech Connect

    BLACK, D.M.

    1999-08-12

    This document presents the Project's position on compliance with DOE Order 6430.1A ''General Design Criteria.'' No non-compliances are shown. The compliance statements have been reviewed and approved by DOE. Open items are scheduled to be closed prior to project completion.

  6. Status Update for Implementing Best Available Technology per DOE Order 5400.5

    SciTech Connect

    Michael G. Lewis

    2003-09-01

    This report identifies discharges of liquid waste streams that require documentation of the best available technology selection process at Bechtel BWXT Idaho, LLC, operated facilities at the Idaho National Engineering and Environmental Laboratory. The best available technology selection process is conducted according to Department of Energy Order 5400.5, Chapter II (3), ''Management and Control of Radioactive Materials in Liquid Discharges and Phaseout of Soil Columns'' and Department of Energy guidance. This report evaluates only those liquid waste streams and facilities where the best available technology selection process was determined to be applicable. In addition, the Department of Energy Idaho Operations Office will submit this report to their field office manager for approval according to DOE Order 5400.5, Chapter II, Section 3.b.(1). According to Department of Energy guidance, ''If the liquid waste stream is below maximum contaminant levels, then the goals of the best available technology selection process are being met and the liquid waste stream is considered 'clean water.' However, it is necessary to document this through the best available technology selection process.'' Because liquid waste streams below drinking water maximum contaminant levels are already considered ''clean water,'' additional treatment technologies are considered unnecessary and unjustifiable on a cost-benefit basis and are not addressed in this report. Two facilities (Idaho Nuclear Technology and Engineering Center New Percolation Ponds and Test Area North/Technical Support Facility Disposal Pond) at the Idaho National Engineering and Environmental Laboratory required documentation of the best available technology selection process (Section 4). These two facilities required documentation of the best available technology selection process because they discharge wastewater that may contain process-derived radionuclides to a soil column even though the average radioactivity levels

  7. Implementation guide for use with DOE Order 440.1: Occupational exposure assessment

    SciTech Connect

    1998-03-30

    DOE O 440.1, Worker Protection Management for DOE Federal and Contractor Employees, establishes the framework for an effective worker protection program that will reduce or prevent accidental injuries and illnesses. One element of the worker protection program in DOE O 440.1 is Exposure Assessment (EA). This Guide provides acceptable methodologies for conducting EA for workers. Exposure assessment should be included in the DOE and contractor written worker protection program, as required by DOE O 440.1. EA documentation should describe the methods and rationale a site uses to characterize and monitor workers` potential and actual exposures to hazardous agents. DOE O 440.1 applies to all activities (including design, construction, operation, maintenance, decontamination and decommissioning, research and development, and environmental restoration activities) performed by DOE and its contractors (and their subcontractors).

  8. Does massive intraabdominal free gas require surgical intervention?

    PubMed Central

    Furihata, Tadashi; Furihata, Makoto; Ishikawa, Kunibumi; Kosaka, Masato; Satoh, Naoki; Kubota, Keiichi

    2016-01-01

    We describe a rare case of an 81-year-old man who presented with severe epigastralgia. A chest radiograph showed massive free gas bilaterally in the diaphragmatic spaces. Computed tomography (CT) scan also showed massive free gas in the peritoneal cavity with portal venous gas. We used a wait-and-see approach and carefully considered surgery again when the time was appropriate. The patient received conservative therapy with fasting, an intravenous infusion of antibiotics, and nasogastric intubation. The patient soon recovered and was able to start eating meals 4 d after treatment; thus, surgical intervention was avoided. Thereafter, colonoscopy examination showed pneumatosis cystoides intestinalis in the ascending colon. On retrospective review, CT scan demonstrated sporadic air-filled cysts in the ascending colon. The present case taught us a lesson: the presence of massive intraabdominal free gas with portal venous gas does not necessarily require surgical intervention. Pneumatosis cystoides intestinalis should be considered as a potential causative factor of free gas with portal venous gas when making the differential diagnosis. PMID:27621584

  9. [Preoperative blood ordering in elective colon surgery: requirement or routine?].

    PubMed

    Feliu, Francesc; Rueda, Juan C; Ramiro, Laia; Olona, Montserrat; Escuder, Jorge; Gris, Fernando; Jiménez, Andrea; Duque, Enric; Vicente, Vicente

    2014-01-01

    Preoperative blood ordering is frequently in elective colon surgery, even for procedures that rarely require blood transfusion. Most often this procedure is performed without proper analysis of the real needs. The aim of this study was to evaluate the patients who receive transfusion and determining their associated factors. Retrospective study of all consecutive patients scheduled for elective colon surgery was carried out at 2007-2012. Several clinico-pathological and surgical variables were analyzed and predictive blood transfusion indices such as the cross-matched/transfusion ratio (C/T ratio), transfusion index and transfusion probability were calculated. Patients were divided in 2 groups according have received perioperative surgical transfusion or not. There were 457 surgery patients. A total of 171 blood units, in a 74 patients were perioperative transfused. Overall cross-matched transfused ratio was 5.34, the transfusion probability 162%, and the transfusion index 0.18. Variables that were significantly associated with receiving blood transfusion in a multivariable analysis were a preoperative haemoglobin level less than 10 g/dl (OR: 309.8; 95% CI: 52.7-985.2), chronic pulmonary obstructive disease (OR: 3.7; 95% CI: 1.3-10.7), oral anticoagulant therapy (OR: 5.7; 95% CI: 1.7-19.4) and surgical time over 120 min (OR: 10.7; 95% CI: 4.7-24.1). Likelihood of receiving perioperative transfusion in elective colon surgery is very low. Among their associated factors, the haemoglobin level less than 10 g/dl is the one with strongest association. Those patients with such low preoperative haemoglobin level should not be scheduled for elective colon surgery until they received specific treatment. Copyright © 2013 AEC. Published by Elsevier Espana. All rights reserved.

  10. Idaho CERCLA Disposal Facility Complex Compliance Demonstration for DOE Order 435.1

    SciTech Connect

    Simonds, J.

    2007-11-06

    This compliance demonstration document provides an analysis of the Idaho CERCLA Disposal Facility (ICDF) Complex compliance with DOE Order 435.1. The ICDF Complex includes the disposal facility (landfill), evaporation pond, administration facility, weigh scale, and various staging/storage areas. These facilities were designed and constructed to be compliant with DOE Order 435.1, Resource Conservation and Recovery act Subtitle C, and Toxic Substances Control Act polychlorinated biphenyl design and construction standards. The ICDF Complex is designated as the Idaho National Laboratory (INL) facility for the receipt, staging/storage, treatment, and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) waste streams.

  11. Idaho CERCLA Disposal Facility Complex Compliance Demonstration for DOE Order 435.1

    SciTech Connect

    Simonds, J.

    2007-11-06

    This compliance demonstration document provides an analysis of the Idaho CERCLA Disposal Facility (ICDF) Complex compliance with DOE Order 435.1. The ICDF Complex includes the disposal facility (landfill), evaporation pond, administration facility, weigh scale, and various staging/storage areas. These facilities were designed and constructed to be compliant with DOE Order 435.1, Resource Conservation and Recovery act Subtitle C, and Toxic Substances Control Act polychlorinated biphenyl design and construction standards. The ICDF Complex is designated as the Idaho National Laboratory (INL) facility for the receipt, staging/storage, treatment, and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) waste streams.

  12. Hazardous Substance Release Reporting Under CERCLA, EPCR {section}304 and DOE Emergency Management System (EMS) and DOE Occurrence Reporting Requirements. Environmental Guidance

    SciTech Connect

    Traceski, T.T.

    1994-06-01

    Releases of various substances from DOE facilities may be subject to reporting requirements under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the Emergency Planning and Community Right-to-Know Act (EPCRA), as well as DOE`s internal ``Occurrence Reporting and Processing of Operations Information`` and the ``Emergency Management System`` (EMS). CERCLA and EPCPA are Federal laws that require immediate reporting of a release of a Hazardous Substance (HS) and an Extremely Hazardous Substance (EHS), respectively, in a Reportable Quantity (RQ) or more within a 24-hour period. This guidance uses a flowchart, supplemental information, and tables to provide an overview of the process to be followed, and more detailed explanations of the actions that must be performed, when chemical releases of HSs, EHSs, pollutants, or contaminants occur at DOE facilities. This guidance should be used in conjunction with, rather than in lieu of, applicable laws, regulations, and DOE Orders. Relevant laws, regulations, and DOE Orders are referenced throughout this guidance.

  13. Transitive Responding in Hooded Crows Requires Linearly Ordered Stimuli

    ERIC Educational Resources Information Center

    Lazareva, Olga F.; Smirnova, Anna A.; Bagozkaja, Maria S.; Zorina, Zoya A.; Rayevsky, Vladimir V.; Wasserman, Edward A.

    2004-01-01

    Eight crows were taught to discriminate overlapping pairs of visual stimuli (A+ B-, B+ C-, C+ D-, and D+ E-). For 4 birds, the stimuli were colored cards with a circle of the same color on the reverse side whose diameter decreased from A to E (ordered feedback group). These circles were made available for comparison to potentially help the crows…

  14. Transitive Responding in Hooded Crows Requires Linearly Ordered Stimuli

    ERIC Educational Resources Information Center

    Lazareva, Olga F.; Smirnova, Anna A.; Bagozkaja, Maria S.; Zorina, Zoya A.; Rayevsky, Vladimir V.; Wasserman, Edward A.

    2004-01-01

    Eight crows were taught to discriminate overlapping pairs of visual stimuli (A+ B-, B+ C-, C+ D-, and D+ E-). For 4 birds, the stimuli were colored cards with a circle of the same color on the reverse side whose diameter decreased from A to E (ordered feedback group). These circles were made available for comparison to potentially help the crows…

  15. 30 CFR 285.420 - What effect does a suspension order have on my payments?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What effect does a suspension order have on my payments? 285.420 Section 285.420 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Lease and...

  16. 21 CFR 1.384 - When does a detention order terminate?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false When does a detention order terminate? 1.384 Section 1.384 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Administrative Detention of Food for Human or Animal Consumption...

  17. 21 CFR 1.384 - When does a detention order terminate?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false When does a detention order terminate? 1.384 Section 1.384 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Administrative Detention of Food for Human or Animal Consumption...

  18. 30 CFR 585.420 - What effect does a suspension order have on my payments?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What effect does a suspension order have on my payments? 585.420 Section 585.420 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL...

  19. 30 CFR 585.420 - What effect does a suspension order have on my payments?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What effect does a suspension order have on my payments? 585.420 Section 585.420 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL...

  20. 30 CFR 585.420 - What effect does a suspension order have on my payments?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What effect does a suspension order have on my payments? 585.420 Section 585.420 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL...

  1. 30 CFR 285.420 - What effect does a suspension order have on my payments?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What effect does a suspension order have on my payments? 285.420 Section 285.420 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON...

  2. Enforcement handbook: Enforcement of DOE nuclear safety requirements

    SciTech Connect

    1995-06-01

    This Handbook provides detailed guidance and procedures to implement the General Statement of DOE Enforcement Policy (Enforcement Policy or Policy). A copy of this Enforcement Policy is included for ready reference in Appendix D. The guidance provided in this Handbook is qualified, however, by the admonishment to exercise discretion in determining the proper disposition of each potential enforcement action. As discussed in subsequent chapters, the Enforcement and Investigation Staff will apply a number of factors in assessing each potential enforcement situation. Enforcement sanctions are imposed in accordance with the Enforcement Policy for the purpose of promoting public and worker health and safety in the performance of activities at DOE facilities by DOE contractors (and their subcontractors and suppliers) who are indemnified under the Price-Anderson Amendments Act. These indemnified contractors, and their suppliers and subcontractors, will be referred to in this Handbook collectively as DOE contractors. It should be remembered that the purpose of the Department`s enforcement policy is to improve nuclear safety for the workers and the public, and this goal should be the prime consideration in exercising enforcement discretion.

  3. Proposed Risk-Informed Seismic Hazard Periodic Reevaluation Methodology for Complying with DOE Order 420.1C

    SciTech Connect

    Kammerer, Annie

    2016-03-01

    Department of Energy (DOE) nuclear facilities must comply with DOE Order 420.1C Facility Safety, which requires that all such facilities review their natural phenomena hazards (NPH) assessments no less frequently than every ten years. The Order points the reader to Standard DOE-STD-1020-2012. In addition to providing a discussion of the applicable evaluation criteria, the Standard references other documents, including ANSI/ANS-2.29-2008 and NUREG-2117. These documents provide supporting criteria and approaches for evaluating the need to update an existing probabilistic seismic hazard analysis (PSHA). All of the documents are consistent at a high level regarding the general conceptual criteria that should be considered. However, none of the documents provides step-by-step detailed guidance on the required or recommended approach for evaluating the significance of new information and determining whether or not an existing PSHA should be updated. Further, all of the conceptual approaches and criteria given in these documents deal with changes that may have occurred in the knowledge base that might impact the inputs to the PSHA, the calculated hazard itself, or the technical basis for the hazard inputs. Given that the DOE Order is aimed at achieving and assuring the safety of nuclear facilities—which is a function not only of the level of the seismic hazard but also the capacity of the facility to withstand vibratory ground motions—the inclusion of risk information in the evaluation process would appear to be both prudent and in line with the objectives of the Order. The purpose of this white paper is to describe a risk-informed methodology for evaluating the need for an update of an existing PSHA consistent with the DOE Order. While the development of the proposed methodology was undertaken as a result of assessments for specific SDC-3 facilities at Idaho National Laboratory (INL), and it is expected that the application at INL will provide a demonstration of the

  4. Proposed Risk-Informed Seismic Hazard Periodic Reevaluation Methodology for Complying with DOE Order 420.1C

    SciTech Connect

    Kammerer, Annie

    2015-10-01

    Department of Energy (DOE) nuclear facilities must comply with DOE Order 420.1C Facility Safety, which requires that all such facilities review their natural phenomena hazards (NPH) assessments no less frequently than every ten years. The Order points the reader to Standard DOE-STD-1020-2012. In addition to providing a discussion of the applicable evaluation criteria, the Standard references other documents, including ANSI/ANS-2.29-2008 and NUREG-2117. These documents provide supporting criteria and approaches for evaluating the need to update an existing probabilistic seismic hazard analysis (PSHA). All of the documents are consistent at a high level regarding the general conceptual criteria that should be considered. However, none of the documents provides step-by-step detailed guidance on the required or recommended approach for evaluating the significance of new information and determining whether or not an existing PSHA should be updated. Further, all of the conceptual approaches and criteria given in these documents deal with changes that may have occurred in the knowledge base that might impact the inputs to the PSHA, the calculated hazard itself, or the technical basis for the hazard inputs. Given that the DOE Order is aimed at achieving and assuring the safety of nuclear facilities—which is a function not only of the level of the seismic hazard but also the capacity of the facility to withstand vibratory ground motions—the inclusion of risk information in the evaluation process would appear to be both prudent and in line with the objectives of the Order. The purpose of this white paper is to describe a risk-informed methodology for evaluating the need for an update of an existing PSHA consistent with the DOE Order. While the development of the proposed methodology was undertaken as a result of assessments for specific SDC-3 facilities at Idaho National Laboratory (INL), and it is expected that the application at INL will provide a demonstration of the

  5. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for determining the suitability of tests? 462.13 Section 462.13 Education Regulations of the Offices... the Secretary Use To Review the Suitability of Tests for Use in the NRS? § 462.13 What criteria and requirements does the Secretary use for determining the suitability of tests? In order for the Secretary to...

  6. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for determining the suitability of tests? 462.13 Section 462.13 Education Regulations of the Offices... the Secretary Use To Review the Suitability of Tests for Use in the NRS? § 462.13 What criteria and requirements does the Secretary use for determining the suitability of tests? In order for the Secretary to...

  7. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for determining the suitability of tests? 462.13 Section 462.13 Education Regulations of the Offices... the Secretary Use To Review the Suitability of Tests for Use in the NRS? § 462.13 What criteria and requirements does the Secretary use for determining the suitability of tests? In order for the Secretary to...

  8. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for determining the suitability of tests? 462.13 Section 462.13 Education Regulations of the Offices... the Secretary Use To Review the Suitability of Tests for Use in the NRS? § 462.13 What criteria and requirements does the Secretary use for determining the suitability of tests? In order for the Secretary to...

  9. 34 CFR 462.13 - What criteria and requirements does the Secretary use for determining the suitability of tests?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for determining the suitability of tests? 462.13 Section 462.13 Education Regulations of the Offices... the Secretary Use To Review the Suitability of Tests for Use in the NRS? § 462.13 What criteria and requirements does the Secretary use for determining the suitability of tests? In order for the Secretary to...

  10. Communication requirements of sparse Cholesky factorization with nested dissection ordering

    NASA Technical Reports Server (NTRS)

    Naik, Vijay K.; Patrick, Merrell L.

    1989-01-01

    Load distribution schemes for minimizing the communication requirements of the Cholesky factorization of dense and sparse, symmetric, positive definite matrices on multiprocessor systems are presented. The total data traffic in factoring an n x n sparse symmetric positive definite matrix representing an n-vertex regular two-dimensional grid graph using n exp alpha, alpha not greater than 1, processors are shown to be O(n exp 1 + alpha/2). It is O(n), when n exp alpha, alpha not smaller than 1, processors are used. Under the conditions of uniform load distribution, these results are shown to be asymptotically optimal.

  11. Communication requirements of sparse Cholesky factorization with nested dissection ordering

    NASA Technical Reports Server (NTRS)

    Naik, Vijay K.; Patrick, Merrell L.

    1989-01-01

    Load distribution schemes for minimizing the communication requirements of the Cholesky factorization of dense and sparse, symmetric, positive definite matrices on multiprocessor systems are presented. The total data traffic in factoring an n x n sparse symmetric positive definite matrix representing an n-vertex regular two-dimensional grid graph using n exp alpha, alpha not greater than 1, processors are shown to be O(n exp 1 + alpha/2). It is O(n), when n exp alpha, alpha not smaller than 1, processors are used. Under the conditions of uniform load distribution, these results are shown to be asymptotically optimal.

  12. 48 CFR 411.101 - Order of precedence for requirements documents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AGRICULTURE COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Selecting and Developing Requirements Documents 411.101 Order of precedence for requirements documents. (a) Office of Management and Budget...

  13. A conceptual framework for using DOE 5700. 6C and the other DOE orders as an integrated management system; the Fermilab experience

    SciTech Connect

    Bodnarczuk, M.

    1992-06-01

    In this paper, I describe a conceptual framework that uses DOE Order 5700.6C and more than 140 other DOE Orders as an integrated management system -- but I describe it within the context of the broader sociological and cultural issues of doing research at DOE funded facilities. The conceptual framework has two components. The first involves an interpretation of the 10 criteria of DOE 5700.6C that is tailored for a research environment. The second component involves using the 10 criteria as functional categories that orchestrate and integrate the other DOE Orders into a total management system. The Fermilab approach aims at reducing (or eliminating) the redundancy and overlap within the DOE Orders system at the contractor level.

  14. A conceptual framework for using DOE 5700.6C and the other DOE orders as an integrated management system; the Fermilab experience

    SciTech Connect

    Bodnarczuk, M.

    1992-06-01

    In this paper, I describe a conceptual framework that uses DOE Order 5700.6C and more than 140 other DOE Orders as an integrated management system -- but I describe it within the context of the broader sociological and cultural issues of doing research at DOE funded facilities. The conceptual framework has two components. The first involves an interpretation of the 10 criteria of DOE 5700.6C that is tailored for a research environment. The second component involves using the 10 criteria as functional categories that orchestrate and integrate the other DOE Orders into a total management system. The Fermilab approach aims at reducing (or eliminating) the redundancy and overlap within the DOE Orders system at the contractor level.

  15. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Reporting requirements for work in support of DOE... RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND DEVELOPMENT AND TESTS, WORK FOR OTHERS § 555.9 Reporting requirements for work in support of DOE....

  16. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... § 35.4170 What kinds of reporting does EPA require? There are several types of reports you need...

  17. 25 CFR 42.6 - When does due process require a formal disciplinary hearing?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When does due process require a formal disciplinary hearing? 42.6 Section 42.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION STUDENT RIGHTS § 42.6 When does due process require a formal disciplinary hearing? Unless local school...

  18. 25 CFR 42.6 - When does due process require a formal disciplinary hearing?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When does due process require a formal disciplinary hearing? 42.6 Section 42.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION STUDENT RIGHTS § 42.6 When does due process require a formal disciplinary hearing? Unless local school...

  19. 48 CFR 908.1102 - Presolicitation requirements. (DOE coverage-paragraph (a))

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Presolicitation requirements. (DOE coverage-paragraph (a)) 908.1102 Section 908.1102 Federal Acquisition Regulations System... Motor Vehicles 908.1102 Presolicitation requirements. (DOE coverage—paragraph (a)) (a)(4) Commercial...

  20. Implementation of the Methamphetamine Anti-Proliferation Act; thresholds for retailers and for distributors required to submit mail order reports; changes to mail order reporting requirements. Final rule.

    PubMed

    2003-10-07

    This regulation implements the new threshold requirements and mail order reporting requirements of the Methamphetamine Anti-Proliferation Act of 2000 (MAPA), which was enacted on October 17, 2000. DEA is amending its regulations to reduce the thresholds for pseudoephedrine and phenylpropanolamine for retail distributors and for distributors required to submit mail order reports. Also, DEA is amending its regulations to require mail order reports for certain export transactions. DEA is codifying exemptions from the mail order reporting requirements for certain distributions to nonregulated persons and certain export transactions. This rule is consistent with the intent of MAPA to prevent the diversion of drug products to the clandestine manufacture of methamphetamine and amphetamine, and simultaneously reduce the industry reporting burden.

  1. Does unbelted safety requirement affect protection for belted occupants?

    PubMed

    Hu, Jingwen; Klinich, Kathleen D; Manary, Miriam A; Flannagan, Carol A C; Narayanaswamy, Prabha; Reed, Matthew P; Andreen, Margaret; Neal, Mark; Lin, Chin-Hsu

    2017-05-29

    Federal regulations in the United States require vehicles to meet occupant performance requirements with unbelted test dummies. Removing the test requirements with unbelted occupants might encourage the deployment of seat belt interlocks and allow restraint optimization to focus on belted occupants. The objective of this study is to compare the performance of restraint systems optimized for belted-only occupants with those optimized for both belted and unbelted occupants using computer simulations and field crash data analyses. In this study, 2 validated finite element (FE) vehicle/occupant models (a midsize sedan and a midsize SUV) were selected. Restraint design optimizations under standardized crash conditions (U.S.-NCAP and FMVSS 208) with and without unbelted requirements were conducted using Hybrid III (HIII) small female and midsize male anthropomorphic test devices (ATDs) in both vehicles on both driver and right front passenger positions. A total of 10 to 12 design parameters were varied in each optimization using a combination of response surface method (RSM) and genetic algorithm. To evaluate the field performance of restraints optimized with and without unbelted requirements, 55 frontal crash conditions covering a greater variety of crash types than those in the standardized crashes were selected. A total of 1,760 FE simulations were conducted for the field performance evaluation. Frontal crashes in the NASS-CDS database from 2002 to 2012 were used to develop injury risk curves and to provide the baseline performance of current restraint system and estimate the injury risk change by removing the unbelted requirement. Unbelted requirements do not affect the optimal seat belt and airbag design parameters in 3 out of 4 vehicle/occupant position conditions, except for the SUV passenger side. Overall, compared to the optimal designs with unbelted requirements, optimal designs without unbelted requirements generated the same or lower total injury risks for

  2. References for HNF-SD-WM-TRD-007, ``System specification for the double-shell tank system: HNF-PROs, CFRs, DOE Orders, WACs``

    SciTech Connect

    Shaw, C.P.

    1998-07-30

    HNF-SD-WM-TRD-O07, System Specification for the Double-Shell Tank System, (hereafter referred to as DST Specification), defines the requirements of the double-shell tank system at the Hanford Site for Phase 1 privatization. Many of the sections in this document reference other documents for design guidance and requirements. Referenced documents include Project Hanford Management Contract (PHMC) procedures (HNF-PROS), Codes of Federal Regulation (CFRs), DOE Orders, and Washington Administrative Codes (WACs). This document provides rationale for the selection and inclusion of HNF-PROS, CFRs, DOE Orders and WACs.

  3. 40 CFR 141.503 - What does subpart T require?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 141.503 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving.... These requirements are: (a) You must cover any finished water reservoir that you began to construct...

  4. 40 CFR 141.503 - What does subpart T require?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 141.503 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving.... These requirements are: (a) You must cover any finished water reservoir that you began to construct...

  5. 40 CFR 141.503 - What does subpart T require?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 141.503 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving.... These requirements are: (a) You must cover any finished water reservoir that you began to construct...

  6. 40 CFR 141.503 - What does subpart T require?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 141.503 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving.... These requirements are: (a) You must cover any finished water reservoir that you began to construct...

  7. 40 CFR 33.301 - What does this subpart require?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... too large for one of these firms to handle individually. (e) Use the services and assistance of the SBA and the Minority Business Development Agency of the Department of Commerce. (f) If the prime contractor awards subcontracts, require the prime contractor to take the steps in paragraphs (a) through...

  8. Geographers as Planners: What Skills Does the Job Require.

    ERIC Educational Resources Information Center

    Stephens, David T.

    A survey of 524 planning agencies and consultants in the Midwest and Southwest was undertaken in 1976 to identify skills required for planning and to assess current capabilities in those skill areas. The major purpose of the survey was to aid geographic educators as they prepare students for careers in the planning profession. One part of the…

  9. The Timing of Acupuncture Stimulation Does Not Influence Anesthetic Requirement

    PubMed Central

    Chernyak, Grigory; Sengupta, Papiya; Lenhardt, Rainer; Liem, Edwin; Doufas, Anthony G.; Sessler, Daniel I.; Akça, Ozan

    2005-01-01

    Studies suggest that acupuncture is more effective when induced before induction of general anesthesia than afterwards. We tested the hypothesis that electro-acupuncture initiated 30 minutes before induction reduces anesthetic requirement more than acupuncture initiated after induction. Seven volunteers were each anesthetized with desflurane on 3 study days. Needles were inserted percutaneously at 4 acupuncture points thought to produce analgesia in the upper abdominal area and provide generalized sedative and analgesic effects: Zusanli (St36), Sanyinjiao (Sp6), Liangqiu (St34), and Hegu (LI4). Needles were stimulated at 2-Hz and 10-Hz, with frequencies alternating at two-second intervals. On Preinduction day, electro-acupuncture was started 30 minutes before induction of anesthesia and maintained throughout the study. On At-induction day, needles were positioned before induction of anesthesia, but electro-acupuncture stimulation was not initiated until after induction. On Control day, electrodes were positioned near the acupoints, but needles were not inserted. Noxious electrical stimulation was administered via 25-G needles on the upper abdomen (70 mA, 100 Hz, 10 seconds). Desflurane concentration was increased 0.5% when movement occurred and decreased 0.5% when it did not. These up-and-down sequences continued until volunteers crossed from movement to no-movement 4 times. The P50 of logistic regression identified desflurane requirement. Desflurane requirement was similar on the Control (5.2±0.6%, mean±SD), Preinduction (5.0±0.8%), and At-induction (4.7±0.3%, P=0.125) days. This type of acupuncture is thus unlikely to facilitate general anesthesia or decrease the need for anesthetic drugs. PMID:15673863

  10. Eye movements and parafoveal preview of compound words: does morpheme order matter?

    PubMed

    Angele, Bernhard; Rayner, Keith

    2013-01-01

    Recently, there has been considerable debate about whether readers can identify multiple words in parallel or whether they are limited to a serial mode of word identification, processing one word at a time (see, e.g., Reichle, Liversedge, Pollatsek, & Rayner, 2009). Similar questions can be applied to bimorphemic compound words: Do readers identify all the constituents of a compound word in parallel, and does it matter which of the morphemes is identified first? We asked subjects to read compound words embedded in sentences while monitoring their eye movements. Using the boundary paradigm (Rayner, 1975), we manipulated the preview that subjects received of the compound word before they fixated it. In particular, the morpheme order of the preview was either normal (cowboy) or reversed (boycow). Additionally, we manipulated the preview availability for each of the morphemes separately. Preview was thus available for the first morpheme only (cowtxg), for the second morpheme only (enzboy), or for neither of the morphemes (enztxg). We report three major findings: First, there was an effect of morpheme order on gaze durations measured on the compound word, indicating that, as expected, readers obtained a greater preview benefit when the preview presented the morphemes in the correct order than when their order was reversed. Second, gaze durations on the compound word were influenced not only by preview availability for the first, but also by that for the second morpheme. Finally, and most importantly, the results show that readers are able to extract some morpheme information even from a reverse order preview. In summary, readers obtain preview benefit from both constituents of a short compound word, even when the preview does not reflect the correct morpheme order.

  11. Glymphatic solute transport does not require bulk flow

    PubMed Central

    Asgari, Mahdi; de Zélicourt, Diane; Kurtcuoglu, Vartan

    2016-01-01

    Observations of fast transport of fluorescent tracers in mouse brains have led to the hypothesis of bulk water flow directed from arterial to venous paravascular spaces (PVS) through the cortical interstitium. At the same time, there is evidence for interstitial solute transport by diffusion rather than by directed bulk fluid motion. It has been shown that the two views may be consolidated by intracellular water flow through astrocyte networks combined with mainly diffusive extracellular transport of solutes. This requires the presence of a driving force that has not been determined to date, but for which arterial pulsation has been suggested as the origin. Here we show that arterial pulsation caused by pulse wave propagation is an unlikely origin of this hypothetical driving force. However, we further show that such pulsation may still lead to fast para-arterial solute transport through dispersion, that is, through the combined effect of local mixing and diffusion in the para-arterial space. PMID:27929105

  12. Glymphatic solute transport does not require bulk flow

    NASA Astrophysics Data System (ADS)

    Asgari, Mahdi; de Zélicourt, Diane; Kurtcuoglu, Vartan

    2016-12-01

    Observations of fast transport of fluorescent tracers in mouse brains have led to the hypothesis of bulk water flow directed from arterial to venous paravascular spaces (PVS) through the cortical interstitium. At the same time, there is evidence for interstitial solute transport by diffusion rather than by directed bulk fluid motion. It has been shown that the two views may be consolidated by intracellular water flow through astrocyte networks combined with mainly diffusive extracellular transport of solutes. This requires the presence of a driving force that has not been determined to date, but for which arterial pulsation has been suggested as the origin. Here we show that arterial pulsation caused by pulse wave propagation is an unlikely origin of this hypothetical driving force. However, we further show that such pulsation may still lead to fast para-arterial solute transport through dispersion, that is, through the combined effect of local mixing and diffusion in the para-arterial space.

  13. Requirements for shipment of DOE radioactive mixed waste

    SciTech Connect

    Gablin, K.; No, Hyo; Herman, J.

    1993-08-01

    There are several sources of radioactive mixed waste (RMW) at Argonne National Laboratory which, in the past, were collected at waste tanks and/or sludge tanks. They were eventually pumped out by special pumps and processed in an evaporator located in the waste operations area in Building No. 306. Some of this radioactive mixed waste represents pure elementary mercury. These cleaning tanks must be manually cleaned up because the RMW material was too dense to pump with the equipment in use. The four tanks being discussed in this report are located in Building No. 306. They are the Acid Waste Tank, IMOX/FLOC Tanks, Evaporation Feed Tanks, and Waste Storage Tanks. All of these tanks are characterized and handled separately. This paper discusses the process and the requirements for characterization and the associated paperwork for Argonne Waste to be shipped to Westinghouse Hanford Company for storage.

  14. Core Problem: Does the CV Parent Body Magnetization require differentiation?

    NASA Astrophysics Data System (ADS)

    O'Brien, T.; Tarduno, J. A.; Smirnov, A. V.

    2016-12-01

    Evidence for the presence of past dynamos from magnetic studies of meteorites can provide key information on the nature and evolution of parent bodies. However, the suggestion of a past core dynamo for the CV parent body based on the study of the Allende meteorite has led to a paradox: a core dynamo requires differentiation, evidence for which is missing in the meteorite record. The key parameter used to distinguish core dynamo versus external field mechanisms is absolute field paleointensity, with high values (>>1 μT) favoring the former. Here we explore the fundamental requirements for absolute field intensity measurement in the Allende meteorite: single domain grains that are non-interacting. Magnetic hysteresis and directional data define strong magnetic interactions, negating a standard interpretation of paleointensity measurements in terms of absolute paleofield values. The Allende low field magnetic susceptibility is dominated by magnetite and FeNi grains, whereas the magnetic remanence is carried by an iron sulfide whose remanence-carrying capacity increases with laboratory cycling at constant field values, indicating reordering. The iron sulfide and FeNi grains are in close proximity, providing mineralogical context for interactions. We interpret the magnetization of Allende to record the intense early solar wind with metal-sulfide interactions amplifying the field, giving the false impression of a higher field value in some prior studies. An undifferentiated CV parent body is thus compatible with Allende's magnetization. Early solar wind magnetization should be the null hypothesis for evaluating the source of magnetization for chondrites and other meteorites.

  15. What does respect for the patient's autonomy require?

    PubMed

    Cheng, Kam-Yuen

    2013-11-01

    Personal autonomy presupposes the notion of rationality. What is not so clear is whether, and how, a compromise of rationality to various degrees will diminish a person's autonomy. In bioethical literature, three major types of threat to the rationality of a patient's medical decision are identified: insufficient information, irrational beliefs/desires, and influence of different framing effects. To overcome the first problem, it is suggested that patients be provided with information about their diseases and treatment choices according to the objective standard. I shall explain how this should be finessed. Regarding the negative impact of irrational beliefs/desires, some philosophers have argued that holding irrational beliefs can still be an expression of autonomy. I reject this argument because the degree of autonomy of a decision depends on the degree of rationality of the beliefs or desires on which the decision is based. Hence, to promote patient autonomy, we need to eliminate irrational beliefs by the provision of evidence and good arguments. Finally, I argue that the way to smooth out the framing effects is to present the same information in different perspectives: it is too often assumed that medical information can always be given in a complete and unadorned manner. This article concludes with a cautionary note that the protection of patient autonomy requires much more time and effort than the current practice usually allows. © 2012 John Wiley & Sons Ltd.

  16. Status Update for Implementation of Best Available Technology per DOE Order 5400.5

    SciTech Connect

    C. A. Major

    1999-07-01

    This report provides an update, as of July 1999, on the implementation of best available technology to control or eliminate radionuclide discharges to soil columns at facilities at the Idaho National Engineering and Environmental Laboratory in accordance with DOE Order 5400.5, ''Radiation Protection of the Public and Environment.'' The best available technology to reduce or eliminate radionuclide discharges to soil columns currently implemented by the different facilities appears to be generally effective. Therefore, the different facilities should continue their current best available technology approaches, and also implement the specific recommendations listed in this report for their respective facility.

  17. Does CPOE support nurse-physician communication in the medication order process? A nursing perspective.

    PubMed

    Saddik, Basema; Al-Mansour, Shaha

    2014-01-01

    The benefits of CPOE are many and have been recognised in the literature as important components for improving patient safety and clinician performance. However, there remain concerns about adverse effects CPOE systems may have on the medication order process and workflow processes. This study explores the perception of nurses regarding the CPOE support on nurse physician communication in the medication order process. A survey was developed measuring perceptions of CPOE features on workflow and nurse physician communication on a Likert scale. The majority of nurses felt that CPOE features supported the medication order process and perceived proper nurse physician communication. CPOE characteristics supported medication order processes and nurse physician communication although nurses reported additional work was required for follow up of physicians. Additional studies utilising in depth methods are recommended to fully understand medication order processes with further CPOE implementation.

  18. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.95 Why does GSA require annual mail management reports? GSA requires annual agency mail management reports to— (a) Ensure that Federal...

  19. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.95 Why does GSA require annual mail management reports? GSA requires annual agency mail management reports to— (a) Ensure that Federal...

  20. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.95 Why does GSA require annual mail management reports? GSA requires annual agency mail management reports to— (a) Ensure that Federal...

  1. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.95 Why does GSA require annual mail management reports? GSA requires annual agency mail management reports to— (a) Ensure that Federal...

  2. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.95 Why does GSA require annual mail management reports? GSA requires annual agency mail management reports to— (a) Ensure that Federal...

  3. 21 CFR 1311.50 - Requirements for recipients of digitally signed orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for Electronic... digital certificate has not expired by checking the expiration date against the date the order was...

  4. 21 CFR 1311.50 - Requirements for recipients of digitally signed orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for Electronic... digital certificate has not expired by checking the expiration date against the date the order was...

  5. 13 CFR 123.513 - Does SBA require collateral on its Military Reservist EIDL?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION DISASTER LOAN PROGRAM Military Reservist Economic Injury Disaster Loans § 123.513 Does SBA require... provide available collateral such as a lien on business property, a security interest in personal...

  6. 48 CFR 1211.101 - Order of precedence for requirements documents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....101 Order of precedence for requirements documents. Safeguards to ensure safety, security (including sensitive information and information technology security) and environmental protection shall be included...

  7. Idaho CERCLA Disposal Facility Complex Compliance Demonstration for DOE Order 435.1

    SciTech Connect

    J. Simonds

    2006-09-01

    This compliance demonstration document provides an analysis of the Idaho CERCLA Disposal Facility (ICDF) Complex compliance with DOE Order 435.1. The ICDF Complex includes the disposal facility (landfill), evaporation pond, admin facility, weigh scale, decon building, treatment systems, and various staging/storage areas. These facilities were designed and are being constructed to be compliant with DOE Order 435.1, Resource Conservation and Recovery Act Subtitle C, and Toxic Substances Control Act polychlorinated biphenyl design and construction standards. The ICDF Complex is designated as the central Idaho National Laboratory (INL) facilityyy for the receipt, staging/storage, treatment, and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) waste streams. This compliance demonstration document discusses the conceptual site model for the ICDF Complex area. Within this conceptual site model, the selection of the area for the ICDF Complex is discussed. Also, the subsurface stratigraphy in the ICDF Complex area is discussed along with the existing contamination beneath the ICDF Complex area. The designs for the various ICDF Complex facilities are also included in this compliance demonstration document. These design discussions are a summary of the design as presented in the Remedial Design/Construction Work Plans for the ICDF landfill and evaporation pond and the Staging, Storage, Sizing, and Treatment Facility. Each of the major facilities or systems is described including the design criteria.

  8. DOE ORDER 435.1, IMPLEMENTATION AND COMPLIANCE DECLARATION AT THE SAVANNAH RIVER SITE AND ACROSS THE DOE COMPLEX IN CONTRAST TO CURRENT PUSHBACK EFFORTS FROM THE ''TOP-TO-BOTTOM'' REVIEW

    SciTech Connect

    GOLDSTON, WELFORD T.; SMITH, WINCHESTER IV

    2003-02-27

    DOE issued Order 435.1, ''Radioactive Waste Management,'' on July 9, 1999 for immediate implementation. The requirements for Low Level Mixed, Transuranic, and High Level Waste have been completely rewritten. The entire DOE complex has been struggling with how to implement these new requirements within the one year required timeframe. This paper will chronicle the implementation strategy and actual results of the work to carry out that strategy at the Savannah River Site. DOE-SR and the site contractors worked closely together to implement each of the new requirements across the SRS, crossing many barriers and providing innovative solutions to the many problems that surfaced throughout the year. The results are that SRS declared compliance with all of the requirements of the Order within the prescribed timeframe. The challenge included all waste types in SRS facilities and programs that handle LLW, MLLW, TRU, and HLW. This paper will describe the implementation details for development of Radioactive Waste Management Basis for each facility, Identification of Wastes with No Path to Disposal, Waste Incidental to Reprocessing Determinations, Low Level Waste 90-Day Staging and One Year Limits for Storage Programs, to name a few of the requirements that were addressed by the SRS 435.1 Implementation Team. This paper will trace the implementation, problems (both technical and administrative), and the current pushback efforts associated with the DOE ''Top-to-Bottom'' review.

  9. Implementation guide for use with suspect/counterfeit items: Requirements of DOE O 440.1, worker protection management; 10 CFR 830.120; and DOE 5700.6C, quality assurance

    SciTech Connect

    1997-06-01

    Department of Energy (DOE) Order (O) 440.1, Worker Protection Management For DOE Federal and Contractors Employees, [7] sets forth requirements for DOE and its contractors to implement suspect and counterfeit items (S/CI) controls as part of the quality assurance (QA) programs required by 10 Code of Federal Regulations (CFR) 830.120 [8] or DOE 5700.6C, Quality Assurance [9]. DOE G-830.120, Implementation Guide for Use with 10 CFR Part 830.120, Quality Assurance, [10] provides additional guidance on establishing and implementing effective QA processes to control S/CIs. DOE O 232.1, Occurrence Reporting and Processing of Operations, [11] specifies requirements for reporting S/CIs under the DOE Occurrence Reporting and Processing System (ORPS). DOE promulgated the requirements and guidance to control or eliminate the hazards posed by S/CIs, which can lead to unexpected equipment failures and undue risks to the DOE mission, the environment, and personnel. This Guide is a compendium of information contained in the referenced DOE directives and other documents concerning S/CI controls. It incorporates, updates, and supersedes earlier guidance issued in Plan for the Suspect/Counterfeit Products Issue in the Department of Energy, dated October 1993, [4] and in memoranda issued by Defense Programs (DP) [12-16] and other DOE program offices. This guidance was developed to strengthen the procurement process, identify and eliminate S/CIs, and improve the reporting of S/CIs. The information in this Guide, when implemented by DOE and its contractors, will satisfy the S/CI requirements contained in the referenced DOE directives.

  10. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for... validated, as incorporated by reference in § 1311.08. (2) The digital signature system and hash function... linked records for orders signed with a CSOS digital certificate must meet the following requirements:...

  11. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... receive an advance payment: Type of report Required information Timing and frequency (a) Federal...

  12. TA-55 Final Safety Analysis Report Comparison Document and DOE Safety Evaluation Report Requirements

    SciTech Connect

    Alan Bond

    2001-04-01

    This document provides an overview of changes to the currently approved TA-55 Final Safety Analysis Report (FSAR) that are included in the upgraded FSAR. The DOE Safety Evaluation Report (SER) requirements that are incorporated into the upgraded FSAR are briefly discussed to provide the starting point in the FSAR with respect to the SER requirements.

  13. What does education have to do with the New International Economic Order

    NASA Astrophysics Data System (ADS)

    Emmerij, Louis

    1982-12-01

    Greater equality in the distribution of incomes, both nationally and internationally, and more intervention to achieve this, both by national governments and international agencies, are identified as the key ideas in the proposed NIEO. Both ideas have provoked a reaction of new conservatism, aided by the current international recession. At least in part, the power of this reaction is the result of a failure in the educational professions and institutions to respond to the requirements of an NIEO in both domestic and global terms. Although the independent effects of education on social change and income distribution have indeed been over-estimated, it remains true, nevertheless, that education does have social and economic effects. Within states, education might be reorganized so as to dissolve the current dichotomy between a `learning' childhood/adolescence and a `non-learning' adulthood. Rather, learning geared to economic activity, change and restructuring might assist both developing and industrialized states to increase incomes and adjust to the requirements of the NIEO. On the international plane, the growth of development studies and of institutions concerned with the domestic effects of international relations and commerce should facilitate a more informed understanding of the balance between self-reliance and interdependence.

  14. 21 CFR 1305.03 - Distributions requiring a Form 222 or a digitally signed electronic order.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Distributions requiring a Form 222 or a digitally signed electronic order. Either a DEA Form 222 or its... laboratory or its agent approved by DEA. (d) Delivery from a central fill pharmacy, as defined in §...

  15. 21 CFR 1305.03 - Distributions requiring a Form 222 or a digitally signed electronic order.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Distributions requiring a Form 222 or a digitally signed electronic order. Either a DEA Form 222 or its... laboratory or its agent approved by DEA. (d) Delivery from a central fill pharmacy, as defined in §...

  16. 21 CFR 1305.03 - Distributions requiring a Form 222 or a digitally signed electronic order.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Distributions requiring a Form 222 or a digitally signed electronic order. Either a DEA Form 222 or its... laboratory or its agent approved by DEA. (d) Delivery from a central fill pharmacy, as defined in §...

  17. 21 CFR 1305.03 - Distributions requiring a Form 222 or a digitally signed electronic order.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Distributions requiring a Form 222 or a digitally signed electronic order. Either a DEA Form 222 or its... laboratory or its agent approved by DEA. (d) Delivery from a central fill pharmacy, as defined in §...

  18. 21 CFR 1305.03 - Distributions requiring a Form 222 or a digitally signed electronic order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Distributions requiring a Form 222 or a digitally signed electronic order. Either a DEA Form 222 or its... laboratory or its agent approved by DEA. (d) Delivery from a central fill pharmacy, as defined in §...

  19. Building a Web-based drug ordering system for hospitals: from requirements engineering to prototyping.

    PubMed

    Hübner, U; Klein, F; Hofstetter, J; Kammeyer, G; Seete, H

    2000-01-01

    Web-based drug ordering allows a growing number of hospitals without pharmacy to communicate seamlessly with their external pharmacy. Business process analysis and object oriented modelling performed together with the users at a pilot hospital resulted in a comprehensive picture of the user and business requirements for electronic drug ordering. The user requirements were further validated with the help of a software prototype. In order to capture the needs of a large number of users CAP10, a new method making use of pre-built models, is proposed. Solutions for coping with the technical requirements (interfacing the business software at the pharmacy) and with the legal requirements (signing the orders) are presented.

  20. Language learning: how much evidence does a child need in order to learn to speak grammatically?

    PubMed

    Page, Karen M

    2004-07-01

    In order to learn grammar from a finite amount of evidence, children must begin with in-built expectations of what is grammatical. They clearly are not born, however, with fully developed grammars. Thus early language development involves refinement of the grammar hypothesis until a target grammar is learnt. Here we address the question of how much evidence is required for this refinement process, by considering two standard learning algorithms and a third algorithm which is presumably as efficient as a child for some value of its memory capacity. We reformulate this algorithm in the context of Chomsky's 'principles and parameters' and show that it is possible to bound the amount of evidence required to almost certainly speak almost grammatically.

  1. Category-specific organization in the human brain does not require visual experience

    PubMed Central

    Mahon, Bradford Z.; Anzellotti, Stefano; Schwarzbach, Jens; Zampini, Massimiliano; Caramazza, Alfonso

    2009-01-01

    Summary The ventral stream refers to a neural pathway that projects from early visual areas through to anterior temporal cortex, and comprises regions in ventral and lateral occipital-temporal cortex. The ventral stream is critical for recognizing visually presented objects. Functional imaging studies of the human brain have shown that different regions within the ventral stream show differential activation to nonliving (tools, houses) and living stimuli (animals, faces). The causes of these category preferences are widely debated. Using functional magnetic resonance imaging, we find that the same regions of the ventral stream that show category preferences for nonliving stimuli and animals in sighted adults, show the same category preferences in adults who are blind since birth. Both blind and sighted participants had larger blood oxygen-level dependent (BOLD) responses in the medial fusiform gyrus for nonliving stimuli compared to animal stimuli, and differential BOLD responses in lateral occipital cortex for animal stimuli compared to nonliving stimuli. These findings demonstrate that the medial-to-lateral bias by conceptual domain in the ventral stream does not require visual experience in order to develop, and suggest the operation of innately determined domain-specific constraints on the organization of object knowledge. PMID:19679078

  2. 40 CFR 141.571 - What records does subpart T require my system to keep?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false What records does subpart T require my system to keep? 141.571 Section 141.571 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration...

  3. 40 CFR 141.571 - What records does subpart T require my system to keep?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false What records does subpart T require my system to keep? 141.571 Section 141.571 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration...

  4. 40 CFR 141.571 - What records does subpart T require my system to keep?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false What records does subpart T require my system to keep? 141.571 Section 141.571 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration...

  5. 40 CFR 141.571 - What records does subpart T require my system to keep?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false What records does subpart T require my system to keep? 141.571 Section 141.571 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration...

  6. 43 CFR 2932.44 - What bonds does BLM require for a Special Recreation Permit?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Recreation Permit? 2932.44 Section 2932.44 Public Lands: Interior Regulations Relating to Public Lands... RECREATION ON PUBLIC LANDS Special Recreation Permits for Commercial Use, Competitive Events, Organized Groups, and Recreation Use in Special Areas § 2932.44 What bonds does BLM require for a Special...

  7. 41 CFR 302-4.403 - Does this exception require authorization by my approving official?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false Does this exception require authorization by my approving official? 302-4.403 Section 302-4.403 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES PERMANENT CHANGE OF STATION (PCS...

  8. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Reporting requirements for work in support of DOE. 555.9 Section 555.9 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND...

  9. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Reporting requirements for work in support of DOE. 555.9 Section 555.9 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND...

  10. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Reporting requirements for work in support of DOE. 555.9 Section 555.9 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY...

  11. 32 CFR 555.9 - Reporting requirements for work in support of DOE.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Reporting requirements for work in support of DOE. 555.9 Section 555.9 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY...

  12. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... projected goals and implementation schedules, and energy and capacity benefits and renewable energy... 10 Energy 4 2013-01-01 2013-01-01 false Does Western require annual IRP progress reports? 905.14 Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated...

  13. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... projected goals and implementation schedules, and energy and capacity benefits and renewable energy... 10 Energy 4 2011-01-01 2011-01-01 false Does Western require annual IRP progress reports? 905.14 Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated...

  14. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... projected goals and implementation schedules, and energy and capacity benefits and renewable energy... 10 Energy 4 2012-01-01 2012-01-01 false Does Western require annual IRP progress reports? 905.14 Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated...

  15. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... projected goals and implementation schedules, and energy and capacity benefits and renewable energy... 10 Energy 4 2014-01-01 2014-01-01 false Does Western require annual IRP progress reports? 905.14 Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated...

  16. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... projected goals and implementation schedules, and energy and capacity benefits and renewable energy... 10 Energy 4 2010-01-01 2010-01-01 false Does Western require annual IRP progress reports? 905.14 Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated...

  17. 7 CFR 170.9 - What type of information does the application require?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false What type of information does the application require? 170.9 Section 170.9 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED...

  18. 43 CFR 3216.14 - What filing fees and forms does a transfer require?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What filing fees and forms does a transfer require? 3216.14 Section 3216.14 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL...

  19. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What does this subpart require agencies to do? 102-3.185 Section 102-3.185 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 3-FEDERAL...

  20. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What does this subpart require agencies to do? 102-3.185 Section 102-3.185 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 3-FEDERAL...

  1. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What does this subpart require agencies to do? 102-3.185 Section 102-3.185 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL 3-FEDERAL...

  2. 40 CFR 35.4170 - What kinds of reporting does EPA require?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false What kinds of reporting does EPA require? 35.4170 Section 35.4170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... the TAG project milestones, including an explanation of special problems your group encountered...

  3. Does the Order of Invasive Species Removal Matter? The Case of the Eagle and the Pig

    PubMed Central

    Collins, Paul W.; Latta, Brian C.; Roemer, Gary W.

    2009-01-01

    Background Invasive species are recognized as a primary driver of native species endangerment and their removal is often a key component of a conservation strategy. Removing invasive species is not always a straightforward task, however, especially when they interact with other species in complex ways to negatively influence native species. Because unintended consequences may arise if all invasive species cannot be removed simultaneously, the order of their removal is of paramount importance to ecological restoration. In the mid-1990s, three subspecies of the island fox Urocyon littoralis were driven to near extinction on the northern California Channel Islands owing to heightened predation by golden eagles Aquila chrysaetos. Eagles were lured to the islands by an abundant supply of feral pigs Sus scrofa and through the process of apparent competition pigs indirectly facilitated the decline in foxes. As a consequence, both pigs and eagles had to be removed to recover the critically endangered fox. Complete removal of pigs was problematic: removing pigs first could force eagles to concentrate on the remaining foxes, increasing their probability of extinction. Removing eagles first was difficult: eagles are not easily captured and lethal removal was politically distasteful. Methodology/Principal Findings Using prey remains collected from eagle nests both before and after the eradication of pigs, we show that one pair of eagles that eluded capture did indeed focus more on foxes. These results support the premise that if the threat of eagle predation had not been mitigated prior to pig removal, fox extinction would have been a more likely outcome. Conclusions/Significance If complete eradication of all interacting invasive species is not possible, the order in which they are removed requires careful consideration. If overlooked, unexpected consequences may result that could impede restoration. PMID:19759894

  4. 41 CFR 102-74.200 - What information are Federal agencies required to report to the Department of Energy (DOE)?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOE Federal Energy Usage Report DOE F 6200.2 Instructions. Ridesharing ... Federal agencies required to report to the Department of Energy (DOE)? 102-74.200 Section 102-74.200...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Energy...

  5. 41 CFR 102-74.200 - What information are Federal agencies required to report to the Department of Energy (DOE)?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... DOE Federal Energy Usage Report DOE F 6200.2 Instructions. Ridesharing ... Federal agencies required to report to the Department of Energy (DOE)? 102-74.200 Section 102-74.200...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Energy...

  6. 41 CFR 102-74.200 - What information are Federal agencies required to report to the Department of Energy (DOE)?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOE Federal Energy Usage Report DOE F 6200.2 Instructions. Ridesharing ... Federal agencies required to report to the Department of Energy (DOE)? 102-74.200 Section 102-74.200...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Energy...

  7. 41 CFR 102-74.200 - What information are Federal agencies required to report to the Department of Energy (DOE)?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOE Federal Energy Usage Report DOE F 6200.2 Instructions. Ridesharing ... Federal agencies required to report to the Department of Energy (DOE)? 102-74.200 Section 102-74.200...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Energy...

  8. 41 CFR 102-74.200 - What information are Federal agencies required to report to the Department of Energy (DOE)?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DOE Federal Energy Usage Report DOE F 6200.2 Instructions. Ridesharing ... Federal agencies required to report to the Department of Energy (DOE)? 102-74.200 Section 102-74.200...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Energy...

  9. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a DOE...

  10. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a DOE...

  11. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a DOE...

  12. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a DOE...

  13. 10 CFR 727.5 - What acknowledgment and consent is required for access to information on DOE computers?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... information on DOE computers? 727.5 Section 727.5 Energy DEPARTMENT OF ENERGY CONSENT FOR ACCESS TO INFORMATION ON DEPARTMENT OF ENERGY COMPUTERS § 727.5 What acknowledgment and consent is required for access to information on DOE computers? An individual may not be granted access to information on a DOE...

  14. 20 CFR 653.501 - Requirements for accepting and processing clearance orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Requirements for accepting and processing clearance orders. (a) In view of the statutorily established basic... and job seekers, neither the ETA nor the State agencies are guarantors of the accuracy or truthfulness... recruited upon by the JS constitute a contractual job offer to which the ETA or a State agency is in any way...

  15. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Protective orders; reporting requirement; sanctions and other actions. 210.34 Section 210.34 Customs Duties UNITED STATES INTERNATIONAL TRADE... time or place; (3) That discovery may be had only by a method of discovery other than that selected...

  16. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for... validated, as incorporated by reference in § 1311.08. (2) The digital signature system and hash function... system that is within five minutes of the official National Institute of Standards and Technology time...

  17. 21 CFR 1311.55 - Requirements for systems used to process digitally signed orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital Certificates for... validated, as incorporated by reference in § 1311.08. (2) The digital signature system and hash function... system that is within five minutes of the official National Institute of Standards and Technology time...

  18. 48 CFR 1211.101 - Order of precedence for requirements documents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... sensitive information and information technology security) and environmental protection shall be included... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Order of precedence for requirements documents. 1211.101 Section 1211.101 Federal Acquisition Regulations System DEPARTMENT OF...

  19. 30 CFR 250.177 - What additional requirements may the Regional Supervisor order for a suspension?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What additional requirements may the Regional Supervisor order for a suspension? 250.177 Section 250.177 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER...

  20. 30 CFR 250.177 - What additional requirements may the Regional Supervisor order for a suspension?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What additional requirements may the Regional Supervisor order for a suspension? 250.177 Section 250.177 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER...

  1. 30 CFR 250.177 - What additional requirements may the Regional Supervisor order for a suspension?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What additional requirements may the Regional Supervisor order for a suspension? 250.177 Section 250.177 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General...

  2. 30 CFR 250.177 - What additional requirements may the Regional Supervisor order for a suspension?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What additional requirements may the Regional Supervisor order for a suspension? 250.177 Section 250.177 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER...

  3. 26 CFR 1.1081-9 - Requirements with respect to order of Securities and Exchange Commission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., expenditure, investment, distribution, or sale unless each of the following requirements is met: (a) The order of the Securities and Exchange Commission must recite that the exchange, expenditure, investment, distribution, or sale is necessary or appropriate to effectuate the provisions of section 11(b) of the...

  4. ASDC Ordering Tool

    Atmospheric Science Data Center

    2017-02-08

    ... Ordering requires login , searching does not. Projects by science discipline: Aerosols | Clouds | Radiation Budget ... Tropospheric Composition | Field Campaigns All projects Details:  ASDC Ordering Tool ...

  5. Guidance document for revision of DOE Order 5820.2A, Radioactive Waste Technical Support Program. Revision 1

    SciTech Connect

    Kudera, D.E.; McMurtrey, C.D.; Meagher, B.G.

    1993-04-01

    This document provides guidance for the revision of DOE Order 5820.2A, ``Radioactive Waste Management.`` Technical Working Groups have been established and are responsible for writing the revised order. The Technical Working Groups will use this document as a reference for polices and procedures that have been established for the revision process. The overall intent of this guidance is to outline how the order will be revised and how the revision process will be managed. In addition, this document outlines technical issues considered for inclusion by a Department of Energy Steering Committee.

  6. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must state...

  7. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must state...

  8. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must state...

  9. 43 CFR 3195.25 - What information must be in my purchase order/contract for a major helium requirement?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... order/contract for a major helium requirement? 3195.25 Section 3195.25 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Agency Requirements § 3195.25 What information must be in my purchase order/contract for a major helium requirement? A purchase order/contract must state...

  10. Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis

    PubMed Central

    Johnson, Tory A.; Pfeffer, Suzanne R.

    2016-01-01

    Human NPC1L1 protein mediates cholesterol absorption in the intestine and liver and is the target of the drug ezetimibe, which is used to treat hypercholesterolemia. Previous studies concluded that NPC1L1-GFP protein trafficking is regulated by cholesterol binding and that ezetimibe blocks NPC1L1-GFP function by inhibiting its endocytosis. We used cell surface biotinylation to monitor NPC1L1-GFP endocytosis and show that ezetimibe does not alter the rate of NPC1L1-GFP endocytosis in cultured rat hepatocytes grown under normal growth conditions. As expected, NPC1L1-GFP endocytosis depends in part on C-terminal, cytoplasmically oriented sequences, but endocytosis does not require cholesterol binding to NPC1L1’s N-terminal domain. In addition, two small- molecule inhibitors of general (and NPC1L1-GFP) endocytosis failed to inhibit the ezetimibe-sensitive uptake of [3H]cholesterol from taurocholate micelles. These experiments demonstrate that cholesterol uptake by NPC1L1 does not require endocytosis; moreover, ezetimibe interferes with NPC1L1’s cholesterol adsorption activity without blocking NPC1L1 internalization in RH7777 cells. PMID:27075173

  11. DOE Integrated Safeguards and Security (DISS) historical document archival and retrieval analysis, requirements and recommendations

    SciTech Connect

    Guyer, H.B.; McChesney, C.A.

    1994-10-07

    The overall primary Objective of HDAR is to create a repository of historical personnel security documents and provide the functionality needed for archival and retrieval use by other software modules and application users of the DISS/ET system. The software product to be produced from this specification is the Historical Document Archival and Retrieval Subsystem The product will provide the functionality to capture, retrieve and manage documents currently contained in the personnel security folders in DOE Operations Offices vaults at various locations across the United States. The long-term plan for DISS/ET includes the requirement to allow for capture and storage of arbitrary, currently undefined, clearance-related documents that fall outside the scope of the ``cradle-to-grave`` electronic processing provided by DISS/ET. However, this requirement is not within the scope of the requirements specified in this document.

  12. Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains.

    PubMed

    Raghunathan, Krishnan; Wong, Tiffany H; Chinnapen, Daniel J; Lencer, Wayne I; Jobling, Michael G; Kenworthy, Anne K

    2016-12-20

    Current models of lipid rafts propose that lipid domains exist as nanoscale compositional fluctuations and these fluctuations can potentially be stabilized into larger domains, consequently better compartmentalizing cellular functions. However, the mechanisms governing stabilized raft assembly and function remain unclear. Here, we test the role of glycolipid crosslinking as a raft targeting and ordering mechanism using the well-studied raft marker cholera toxin B pentamer (CTxB) that binds up to five GM1 glycosphingolipids to enter host cells. We show that when applied to cell-derived giant plasma membrane vesicles, a variant of CTxB containing only a single functional GM1 binding site exhibits significantly reduced partitioning to the ordered phase compared to wild-type CTxB with five binding sites. Moreover, monovalent CTxB does not stabilize membrane domains, unlike wild-type CTxB. These results support the long-held hypothesis that CTxB stabilizes raft domains via a lipid crosslinking mechanism and establish a role for crosslinking in the partitioning of CTxB to ordered domains.

  13. Robust order representation is required for backward recall in the Corsi blocks task

    PubMed Central

    Higo, Katsuki; Minamoto, Takehiro; Ikeda, Takashi; Osaka, Mariko

    2014-01-01

    The storage and processing of spatial information is done by spatial working memory. To measure spatial working memory, the Corsi blocks task, which separates the memory into two types, forward and backward, is often used. Although it had been thought that backward recall requires more of the executive function than forward recall, some studies have shown otherwise. Here, we focused on the spatial and sequential aspects of the Corsi blocks task to investigate cognitive processes by dissociating forward and backward recall. We used a dual task method (serial articulatory suppression or spatial tapping as the secondary task) and analyzed two kinds of errors (position error and order error) to investigate cognitive performance during the forward and backward recall. We ran two experiments: in experiment 1, we employed the standard Corsi blocks task, and in experiment 2, we employed the modified Corsi blocks task in order to prevent verbal strategies. We found that spatial tapping affected both forward and backward recall, while serial articulatory suppression increased the number of order errors in the backward condition. These results indicate that stronger order representation is required for backward recall in the Corsi blocks task. PMID:25426092

  14. Using Department of Energy (DOE) Order 435.1 To Find a Cost Effective Waste Management Option. - 12241

    SciTech Connect

    LaBarge, Matt; Frost, Matt

    2012-07-01

    The Depleted Uranium Hexafluoride Project in Portsmouth Ohio was faced with an interesting dilemma. During hot functional testing in August 2010, an upset condition caused gaseous depleted uranium hexafluoride (UF{sub 6}) to come in contact with the hydrofluoric acid (HF) vapor stream. Although the resulting uranium contamination found in the condensed aqueous hydrofluoric acid was very low, it exceeded the Department of Energy (DOE) authorized release limit. After evaluating several commercial options for treatment and disposal using the guidelines found in DOE Order 435.1, Waste Control Specialists LLC was selected for the treatment of the waste, with EnergySolutions' Clive facility selected for disposal of the treated residues. The waste was safely transported from Piketon, Ohio to Andrews, Texas, where it was treated to meet the land Disposal Restrictions (LDR), and was disposed in EnergySolutions operational mixed waste cell. The entire effort was interesting for several reasons. The waste was generated during the last year of the first Depleted Uranium Hexafluoride contractor. The waste became additional scope for the new contractor, adding time delays and introducing new personnel into the project. The effort was also unique because it demonstrated the process mandated by DOE Order 435.1 to evaluate all options, including commercial options, could reveal solutions to waste management problems that are currently available and more cost effective, but not well know within the DOE complex. (authors)

  15. DOE nuclear material packaging manual: storage container requirements for plutonium oxide materials

    SciTech Connect

    Veirs, D Kirk

    2009-01-01

    Loss of containment of nuclear material stored in containers such as food-pack cans, paint cans, or taped slip lid cans has generated concern about packaging requirements for interim storage of nuclear materials in working facilities such as the plutonium facility at Los Alamos National Laboratory (LANL). In response, DOE has recently issued DOE M 441.1 'Nuclear Material Packaging Manual' with encouragement from the Defense Nuclear Facilities Safety Board. A unique feature compared to transportation containers is the allowance of filters to vent flammable gases during storage. Defining commonly used concepts such as maximum allowable working pressure and He leak rate criteria become problematic when considering vented containers. Los Alamos has developed a set of container requirements that are in compliance with 441.1 based upon the activity of heat-source plutonium (90% Pu-238) oxide, which bounds the requirements for weapons-grade plutonium oxide. The pre and post drop-test He leak rates depend upon container size as well as the material contents. For containers that are routinely handled, ease of handling and weight are a major consideration. Relatively thin-walled containers with flat bottoms are desired yet they cannot be He leak tested at a differential pressure of one atmosphere due to the potential for plastic deformation of the flat bottom during testing. The He leak rates and He leak testing configuration for containers designed for plutonium bearing materials will be presented. The approach to meeting the other manual requirements such as corrosion and thermal degradation resistance will be addressed. The information presented can be used by other sites to evaluate if their conditions are bounded by LANL requirements when considering procurement of 441.1 compliant containers.

  16. Order of Presentation of Dimensions Does Not Systematically Bias Utility Weights from a Discrete Choice Experiment.

    PubMed

    Norman, Richard; Kemmler, Georg; Viney, Rosalie; Pickard, A Simon; Gamper, Eva; Holzner, Bernhard; Nerich, Virginie; King, Madeleine

    2016-12-01

    Discrete choice experiments (DCEs) are increasingly used to value aspects of health. An issue with their adoption is that results may be sensitive to the order in which dimensions of health are presented in the valuation task. Findings in the literature regarding order effects are discordant at present. To quantify the magnitude of order effect of quality-of-life (QOL) dimensions within the context of a DCE designed to produce country-specific value sets for the EORTC Quality of Life Utility Measure-Core 10 dimensions (QLU-C10D), a new utility instrument derived from the widely used cancer-specific QOL questionnaire, the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30. The DCE comprised 960 choice sets, divided into 60 versions of 16 choice sets, with each respondent assigned to a version. Within each version, the order of QLU-C10D QOL dimensions was randomized, followed by life duration in the last position. The DCE was completed online by 2053 individuals in France and Germany. We analyzed the data with a series of conditional logit models, adjusted for repeated choices within respondent. We used F tests to assess order effects, correcting for multiple hypothesis testing. Each F test failed to reject the null hypothesis of no position effect: 1) all QOL order positions considered jointly; 2) last QOL position only; 3) first QOL position only. Furthermore, the order coefficients were small relative to those of the QLU-C10D QOL dimension levels. The order of presentation of QOL dimensions within a DCE designed to provide utility weights for the QLU-C10D had little effect on level coefficients of those QOL dimensions. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  17. Arrival order among native plant functional groups does not affect invasibility of constructed dune communities.

    PubMed

    Mason, T J; French, K; Jolley, D

    2013-10-01

    Different arrival order scenarios of native functional groups to a site may influence both resource use during development and final community structure. Arrival order may then indirectly influence community resistance to invasion. We present a mesocosm experiment of constructed coastal dune communities that monitored biotic and abiotic responses to different arrival orders of native functional groups. Constructed communities were compared with unplanted mesocosms. We then simulated a single invasion event by bitou (Chrysanthemoides monilifera ssp. rotundata), a dominant exotic shrub of coastal communities. We evaluated the hypothesis that plantings with simultaneous representation of grass, herb and shrub functional groups at the beginning of the experiment would more completely sequester resources and limit invasion than staggered plantings. Staggered plantings in turn would offer greater resource use and invasion resistance than unplanted mesocosms. Contrary to our expectations, there were few effects of arrival order on abiotic variables for the duration of the experiment and arrival order was unimportant in final community invasibility. All planted mesocosms supported significantly more invader germinants and significantly less invader abundance than unplanted mesocosms. Native functional group plantings may have a nurse effect during the invader germination and establishment phase and a competitive function during the invader juvenile and adult phase. Arrival order per se did not affect resource use and community invasibility in our mesocosm experiment. While grass, herb and shrub functional group plantings will not prevent invasion success in restored communities, they may limit final invader biomass.

  18. NERSC Cyber Security Challenges That Require DOE Development andSupport

    SciTech Connect

    Draney, Brent; Campbell, Scott; Walter, Howard

    2007-01-16

    Traditional security approaches do not adequately addressall the requirements of open, scientific computing facilities. Many ofthe methods used for more restricted environments, including almost allcorporate/commercial systems, do not meet the needs of today's science.Use of only the available "state of the practice" commercial methods willhave adverse impact on the ability of DOE to accomplish its sciencegoals, and impacts the productivity of the DOE Science community. Inparticular, NERSC and other high performance computing (HPC) centers havespecial security challenges that are unlikely to be met unless DOE fundsdevelopment and support of reliable and effective tools designed to meetthe cyber security needs of High Performance Science. The securitychallenges facing NERSC can be collected into three basic problem sets:network performance and dynamics, application complexity and diversity,and a complex user community that can have transient affiliations withactual institutions. To address these problems, NERSC proposes thefollowing four general solutions: auditing user and system activityacross sites; firewall port configuration in real time;cross-site/virtual organization identity management and access control;and detecting security issues in application middleware. Solutions arealsoproposed for three general long term issues: data volume,application complexity, and information integration.

  19. Pre-registration house officer rotations incorporating general practice: does the order of rotation matter?

    PubMed

    Williams, C; Cantillon, P; Cochrane, M

    2001-06-01

    In relation to pre-registration house officer (PRHO) rotations incorporating general practice, previous research has recommended that where possible, no PRHO should undertake general practice as the first placement, because of the difficulties encountered. It was recognized that logistically, this could make such schemes almost unworkable. Within the context of a larger qualitative evaluation comparing how 24 PRHOs learned in hospital and general practice settings, the issue of rotation order was explored. In-depth semistructured interviews were conducted with the 12 PRHOs who were involved in general practice rotations. They were interviewed at the beginning and end of the PRHO year, and following their return to hospital work after the general practice placement. Each rotation order had both advantages and disadvantages, with no particular rotation order being obviously better or worse for the PRHOs involved. This small qualitative evaluation has highlighted a number of advantages and disadvantages specific to each rotation order, and makes some practical recommendations to help alleviate the problems encountered. It is important that future evaluations of similar schemes consider this issue, as there are conflicting reports about the significance of the rotation order.

  20. Analysis of waste treatment requirements for DOE mixed wastes: Technical basis

    SciTech Connect

    1995-02-01

    The risks and costs of managing DOE wastes are a direct function of the total quantities of 3wastes that are handled at each step of the management process. As part of the analysis of the management of DOE low-level mixed wastes (LLMW), a reference scheme has been developed for the treatment of these wastes to meet EPA criteria. The treatment analysis in a limited form was also applied to one option for treatment of transuranic wastes. The treatment requirements in all cases analyzed are based on a reference flowsheet which provides high level treatment trains for all LLMW. This report explains the background and basis for that treatment scheme. Reference waste stream chemical compositions and physical properties including densities were established for each stream in the data base. These compositions are used to define the expected behavior for wastes as they pass through the treatment train. Each EPA RCRA waste code was reviewed, the properties, chemical composition, or characteristics which are of importance to waste behavior in treatment were designated. Properties that dictate treatment requirements were then used to develop the treatment trains and identify the unit operations that would be included in these trains. A table was prepared showing a correlation of the waste physical matrix and the waste treatment requirements as a guide to the treatment analysis. The analysis of waste treatment loads is done by assigning wastes to treatment steps which would achieve RCRA compliant treatment. These correlation`s allow one to examine the treatment requirements in a condensed manner and to see that all wastes and contaminant sets are fully considered.

  1. Root growth regulation and gravitropism in maize roots does not require the epidermis

    NASA Technical Reports Server (NTRS)

    Bjorkman, T.; Cleland, R. E.

    1991-01-01

    We have earlier published observations showing that endogenous alterations in growth rate during gravitropism in maize roots (Zea mays L.) are unaffected by the orientation of cuts which remove epidermal and cortical tissue in the growing zone (Bjorkman and Cleland, 1988, Planta 176, 513-518). We concluded that the epidermis and cortex are not essential for transporting a growth-regulating signal in gravitropism or straight growth, nor for regulating the rate of tissue expansion. This conclusion has been challenged by Yang et al. (1990, Planta 180, 530-536), who contend that a shallow girdle around the entire perimeter of the root blocks gravitropic curvature and that this inhibition is the result of a requirement for epidermal cells to transport the growth-regulating signal. In this paper we demonstrate that the entire epidermis can be removed without blocking gravitropic curvature and show that the position of narrow girdles does not affect the location of curvature. We therefore conclude that the epidermis is not required for transport of a growth-regulating substance from the root cap to the growing zone, nor does it regulate the growth rate of the elongating zone of roots.

  2. Root growth regulation and gravitropism in maize roots does not require the epidermis

    NASA Technical Reports Server (NTRS)

    Bjorkman, T.; Cleland, R. E.

    1991-01-01

    We have earlier published observations showing that endogenous alterations in growth rate during gravitropism in maize roots (Zea mays L.) are unaffected by the orientation of cuts which remove epidermal and cortical tissue in the growing zone (Bjorkman and Cleland, 1988, Planta 176, 513-518). We concluded that the epidermis and cortex are not essential for transporting a growth-regulating signal in gravitropism or straight growth, nor for regulating the rate of tissue expansion. This conclusion has been challenged by Yang et al. (1990, Planta 180, 530-536), who contend that a shallow girdle around the entire perimeter of the root blocks gravitropic curvature and that this inhibition is the result of a requirement for epidermal cells to transport the growth-regulating signal. In this paper we demonstrate that the entire epidermis can be removed without blocking gravitropic curvature and show that the position of narrow girdles does not affect the location of curvature. We therefore conclude that the epidermis is not required for transport of a growth-regulating substance from the root cap to the growing zone, nor does it regulate the growth rate of the elongating zone of roots.

  3. Does Higher-Order Thinking Impinge on Learner-Centric Digital Approach?

    ERIC Educational Resources Information Center

    Mathew, Bincy; Raja, B. William Dharma

    2015-01-01

    Humans are social beings and the social cognition focuses on how one form impressions of other people, interpret the meaning of other people's behaviour and how people's behaviour is affected by our attitudes. The school provides complex social situations and in order to thrive, students must possess social cognition, the process of thinking about…

  4. Does Higher-Order Thinking Impinge on Learner-Centric Digital Approach?

    ERIC Educational Resources Information Center

    Mathew, Bincy; Raja, B. William Dharma

    2015-01-01

    Humans are social beings and the social cognition focuses on how one form impressions of other people, interpret the meaning of other people's behaviour and how people's behaviour is affected by our attitudes. The school provides complex social situations and in order to thrive, students must possess social cognition, the process of thinking about…

  5. Intimate Partner Violence, Relationship Status, and Protective Orders: Does "Living in Sin" Entail a Different Experience?

    ERIC Educational Resources Information Center

    Shannon, Lisa; Logan, T. K.; Cole, Jennifer

    2007-01-01

    The legal status of women's intimate relationships may allow for different experiences with intimate partner violence (IPV) and the protections received from the criminal justice system. There has been limited research examining differences in IPV and protective orders for women in marital and cohabiting intimate relationships. This study examines…

  6. 21 CFR 1.378 - What criteria does FDA use to order a detention?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....378 Section 1.378 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... employee of FDA may order the detention of any article of food that is found during an inspection... the article of food is adulterated or misbranded....

  7. Intimate Partner Violence, Relationship Status, and Protective Orders: Does "Living in Sin" Entail a Different Experience?

    ERIC Educational Resources Information Center

    Shannon, Lisa; Logan, T. K.; Cole, Jennifer

    2007-01-01

    The legal status of women's intimate relationships may allow for different experiences with intimate partner violence (IPV) and the protections received from the criminal justice system. There has been limited research examining differences in IPV and protective orders for women in marital and cohabiting intimate relationships. This study examines…

  8. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from...

  9. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2010-07-01 2010-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department of...

  10. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2011-07-01 2011-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department of...

  11. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2013-07-01 2013-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department of...

  12. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2014-07-01 2014-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department of...

  13. 34 CFR 403.184 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Financial Conditions Must Be Met by a State? § 403.184 How does... 34 Education 3 2012-07-01 2012-07-01 false How does a State request a waiver of the maintenance of effort requirement? 403.184 Section 403.184 Education Regulations of the Offices of the Department of...

  14. 43 CFR 404.60 - Does this rule contain an information collection that requires approval by the Office of...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Does this rule contain an information collection that requires approval by the Office of Management and Budget (OMB)? 404.60 Section 404.60 Public... RECLAMATION RURAL WATER SUPPLY PROGRAM Miscellaneous § 404.60 Does this rule contain an information...

  15. 43 CFR 404.60 - Does this rule contain an information collection that requires approval by the Office of...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Does this rule contain an information collection that requires approval by the Office of Management and Budget (OMB)? 404.60 Section 404.60 Public... RECLAMATION RURAL WATER SUPPLY PROGRAM Miscellaneous § 404.60 Does this rule contain an information...

  16. 43 CFR 404.60 - Does this rule contain an information collection that requires approval by the Office of...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Does this rule contain an information collection that requires approval by the Office of Management and Budget (OMB)? 404.60 Section 404.60 Public... RECLAMATION RURAL WATER SUPPLY PROGRAM Miscellaneous § 404.60 Does this rule contain an information...

  17. 43 CFR 404.60 - Does this rule contain an information collection that requires approval by the Office of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Does this rule contain an information collection that requires approval by the Office of Management and Budget (OMB)? 404.60 Section 404.60 Public... RECLAMATION RURAL WATER SUPPLY PROGRAM Miscellaneous § 404.60 Does this rule contain an information...

  18. 43 CFR 404.60 - Does this rule contain an information collection that requires approval by the Office of...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Does this rule contain an information collection that requires approval by the Office of Management and Budget (OMB)? 404.60 Section 404.60 Public... RECLAMATION RURAL WATER SUPPLY PROGRAM Miscellaneous § 404.60 Does this rule contain an information...

  19. 20 CFR 411.410 - Does each referral from an EN to a State VR agency require its own agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Does each referral from an EN to a State VR agency require its own agreement? 411.410 Section 411.410 Employees' Benefits SOCIAL SECURITY...' Participation Agreements Between Employment Networks and State Vr Agencies § 411.410 Does each referral from...

  20. OCTET does not demonstrate a lack of effectiveness for community treatment orders.

    PubMed

    Curtis, David

    2014-02-01

    In the Oxford Community Treatment Order Evaluation Trial (OCTET), patients were randomised either to be made subject to a community treatment order (CTO) or to be managed with Section 17 leave and discharge. No differences in outcome between the two groups were observed. Here it is argued that the patients studied were not those who might have benefited from a CTO and that the psychiatrists involved were unlikely to have used the provisions of a CTO assertively. Consideration of the lengths of time for which both Section 17 leave and CTOs were used supports the notion that CTOs were not used appropriately for a group of patients who might have benefited from them. Hence the results of this study should not be taken to provide any evidence as to the effectiveness or otherwise of CTOs.

  1. 45 CFR 286.230 - What if a Tribe does not have reasonable cause for failing to meet a requirement?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... failing to meet a requirement? 286.230 Section 286.230 Public Welfare Regulations Relating to Public... a Tribe does not have reasonable cause for failing to meet a requirement? (a) To avoid the... not claim reasonable cause for failing to meet a requirement; or (2) If we found that a Tribe did not...

  2. The order of concurrent training does not affect soccer-related performance adaptations.

    PubMed

    McGawley, K; Andersson, P-I

    2013-11-01

    Despite the wealth of evidence regarding physical training strategies in soccer, there is little information regarding soccer-specific concurrent training and the effects of training order. The current study aimed to: i) quantify the effects of concurrent high-intensity run-based training (HIT) and strength- and power-based training (STR) on soccer-specific performance, and ii) investigate the order effect of completing HIT and STR either first or second within training sessions. Eighteen semi- and fully-professional players completed a battery of field- and gym-based tests before and after a 5-week pre-season training intervention. Players were pair-matched and completed 3 sessions per week of HIT followed by STR (n=9) or STR followed by HIT (n=9). ANCOVA tests revealed no differences between groups for changes in any of the measures (p>0.05). However, a training effect was observed for all measures (p<0.05), with 10-m sprint, 6×30-m repeated sprint, 40-m agility and Yo-Yo test performances improving by 1.8±2.6%, 1.3±1.8%, 1.0±1.5% and 19.4±23.4%, respectively (n=18). In conclusion, there was a positive effect of the concurrent training approach on key measures of soccer performance, but the order of completing HIT and STR appears inconsequential to performance adaptations. © Georg Thieme Verlag KG Stuttgart · New York.

  3. Higher order thinking skills competencies required by outcomes-based education from learners.

    PubMed

    Chabeli, M M

    2006-08-01

    Outcomes-Based Education (OBE) brought about a significant paradigm shift in the education and training of learners in South Africa. OBE requires a shift from focusing on the teacher input (instruction offerings or syllabuses expressed in terms of content), to focusing on learner outcomes. OBE is moving away from 'transmission' models to constructivistic, learner-centered models that put emphasis on learning as an active process (Nieburh, 1996:30). Teachers act as facilitators and mediators of learning (Norms and Standards, Government Gazette vol 415, no 20844 of 2000). Facilitators are responsible to create the environment that is conducive for learners to construct their own knowledge, skills and values through interaction (Peters, 2000). The first critical cross-field outcome accepted by the South African Qualification Framework (SAQA) is that learners should be able to identify and solve problems by using critical and creative thinking skills. This paper seeks to explore some higher order thinking skills competencies required by OBE from learners such as critical thinking, reflective thinking, creative thinking, dialogic / dialectic thinking, decision making, problem solving and emotional intelligence and their implications in facilitating teaching and learning from the theoretical perspective. The philosophical underpinning of these higher order thinking skills is described to give direction to the study. It is recommended that a study focusing on the assessment of these intellectual concepts be made. The study may be qualitative, quantitative or mixed methods in nature (Creswell 2005).

  4. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital... signing orders. (a) Only the certificate holder may access or use his or her digital certificate...

  5. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., DEPARTMENT OF JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS Obtaining and Using Digital... signing orders. (a) Only the certificate holder may access or use his or her digital certificate...

  6. How does participation in inquiry-based activities influence gifted students' higher order thinking?

    NASA Astrophysics Data System (ADS)

    Reger, Barbara H.

    Inquiry-based learning is considered a useful technique to strengthen the critical thinking skills of students. The National Science Standards emphasize its use and the complexities and challenge it provides are well suited for meeting the needs of the gifted. While many studies have documented the effectiveness of this type of instruction, there is a lack of research on growth in higher-order thinking through participation in science inquiry. This study investigated such growth among a small group of gifted fifth-grade students. In this study a group of fifth-grade gifted science students completed a series of three forensics inquiry lessons, and documented questions, ideas and reflections as they constructed evidence to solve a crime. From this class of students, one small group was purposely selected to serve as the focus of the study. Using qualitative techniques, the questions and statements students made as they interacted in the activity were analyzed. Videotaped comments and student logs were coded for emerging patterns and also examined for evidence of increased levels of higher-order thinking based on a rubric that was designed using the six levels of Bloom's Taxonomy. Evidence from this study showed marked increase in and deeper levels of higher-order thinking for two of the students. The other boy and girl showed progress using the inquiry activities, but it was not as evident. The social dynamics of the group seemed to hinder one girl's participation during some of the activities. The social interactions played a role in strengthening the exchange of ideas and thinking skills for the others. The teacher had a tremendous influence over the production of higher-level statements by modeling that level of thinking as she questioned the students. Through her practice of answering a question with a question, she gradually solicited more analytical thinking from her students.

  7. 20 CFR 10.909 - How does an employee designate a variation in the order or percentage of gratuity payable to...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How does an employee designate a variation in...' COMPENSATION ACT, AS AMENDED Death Gratuity § 10.909 How does an employee designate a variation in the order or...) Form CA-40 must be used to make a variation in the order or percentages of survivors under § 10.907...

  8. 12 CFR 1202.6 - What if my request does not have all the information FHFA requires?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false What if my request does not have all the information FHFA requires? 1202.6 Section 1202.6 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS FREEDOM OF INFORMATION ACT § 1202.6 What if my request does not have all the information FHFA requires? If the FHFA...

  9. Material characterization for morphing purposes in order to match flight requirements

    NASA Astrophysics Data System (ADS)

    Geier, Sebastian; Kintscher, Markus; Heintze, Olaf; Wierach, Peter; Monner, Hans-Peter; Wiedemann, Martin

    2012-04-01

    Natural laminar flow is one of the challenging aims of the current aerospace research. Main reasons for the aerodynamic transition from laminar into turbulent flow focusing on the airfoil-structure is the aerodynamic shape and the surface roughness. The Institute of Composite Structures and Adaptive Systems at the German Aerospace Center in Braunschweig works on the optimization of the aerodynamic-loaded structure of future aircrafts in order to increase their efficiency. Providing wing structures suited for natural laminar flow is a step towards this goal. Regarding natural laminar flow, the structural design of the leading edge of a wing is of special interest. An approach for a gap-less leading edge was developed to provide a gap- and step-less high quality surface suited for natural laminar flow and to reduce slat noise. In a national project the first generation of the 3D full scale demonstrator was successfully tested in 2010. The prototype consists of several new technologies, opening up the issue of matching the long and challenging list of airworthiness requirements simultaneously. Therefore the developed composite structure was intensively tested for further modifications according to meet requirements for abrasion, impact and deicing basically. The former presented structure consists completely of glass-fiber-prepreg (GFRP-prepreg). New functions required the addition of a new material-mix, which has to fit into the manufacturing-chain of the composite structure. In addition the hybrid composites have to withstand high loadings, high bending-induced strains (1%) and environmentally influenced aging. Moreover hot-wet cycling tests are carried out for the basic GFRP-structure in order to simulate the long term behavior of the material under extrem conditions. The presented paper shows results of four-points-bending-tests of the most critical section of the morphing leading edge device. Different composite-hybrids are built up and processed. An experimental

  10. A reverse order interview does not aid deception detection regarding intentions

    PubMed Central

    Fenn, Elise; McGuire, Mollie; Langben, Sara; Blandón-Gitlin, Iris

    2015-01-01

    Promising recent research suggests that more cognitively demanding interviews improve deception detection accuracy. Would these cognitively demanding techniques work in the same way when discriminating between true and false future intentions? In Experiment 1 participants planned to complete a task, but instead were intercepted and interviewed about their intentions. Participants lied or told the truth, and were subjected to high (reverse order) or low (sequential order) cognitive load interviews. Third-party observers watched these interviews and indicated whether they thought the person was lying or telling the truth. Subjecting participants to a reverse compared to sequential interview increased the misidentification rate and the appearance of cognitive load in truth tellers. People lying about false intentions were not better identified. In Experiment 2, a second set of third-party observers rated behavioral cues. Consistent with Experiment 1, truth tellers, but not liars, exhibited more behaviors associated with lying and fewer behaviors associated with truth telling in the reverse than sequential interview. Together these results suggest that certain cognitively demanding interviews may be less useful when interviewing to detect false intentions. Explaining a true intention while under higher cognitive demand places truth tellers at risk of being misclassified. There may be such a thing as too much cognitive load induced by certain techniques PMID:26379610

  11. Heterochromatic self-association, a determinant of nuclear organization, does not require sequence homology in Drosophila.

    PubMed Central

    Sage, Brian T; Csink, Amy K

    2003-01-01

    Chromosomes of higher eukaryotes contain blocks of heterochromatin that can associate with each other in the interphase nucleus. A well-studied example of heterochromatic interaction is the brown(Dominant) (bwD) chromosome of D. melanogaster, which contains an approximately 1.6-Mbp insertion of AAGAG repeats near the distal tip of chromosome 2. This insertion causes association of the tip with the centric heterochromatin of chromosome 2 (2h), which contains megabases of AAGAG repeats. Here we describe an example, other than bwD, in which distally translocated heterochromatin associates with centric heterochromatin. Additionally, we show that when a translocation places bwD on a different chromosome, bwD tends to associate with the centric heterochromatin of this chromosome, even when the chromosome contains a small fraction of the sequence homology present elsewhere. To further test the importance of sequence homology in these interactions, we used interspecific mating to introgress the bwD allele from D. melanogaster into D. simulans, which lacks the AAGAG on the autosomes. We find that D. simulans bwD associates with 2h, which lacks the AAGAG sequence, while it does not associate with the AAGAG containing X chromosome heterochromatin. Our results show that intranuclear association of separate heterochromatic blocks does not require that they contain the same sequence. PMID:14668374

  12. An in fiber experimental approach to photonic quantum digital signatures that does not require quantum memory

    NASA Astrophysics Data System (ADS)

    Collins, Robert J.; Donaldon, Ross J.; Dunjko, Vedran; Wallden, Petros; Clarke, Patrick J.; Andersson, Erika; Jeffers, John; Buller, Gerald S.

    2014-10-01

    Classical digital signatures are commonly used in e-mail, electronic financial transactions and other forms of electronic communications to ensure that messages have not been tampered with in transit, and that messages are transferrable. The security of commonly used classical digital signature schemes relies on the computational difficulty of inverting certain mathematical functions. However, at present, there are no such one-way functions which have been proven to be hard to invert. With enough computational resources certain implementations of classical public key cryptosystems can be, and have been, broken with current technology. It is nevertheless possible to construct information-theoretically secure signature schemes, including quantum digital signature schemes. Quantum signature schemes can be made information theoretically secure based on the laws of quantum mechanics, while classical comparable protocols require additional resources such as secret communication and a trusted authority. Early demonstrations of quantum digital signatures required quantum memory, rendering them impractical at present. Our present implementation is based on a protocol that does not require quantum memory. It also uses the new technique of unambiguous quantum state elimination, Here we report experimental results for a test-bed system, recorded with a variety of different operating parameters, along with a discussion of aspects of the system security.

  13. The onset of heroin use and criminal behaviour: does order make a difference?

    PubMed

    Kaye, S; Darke, S; Finlay-Jones, R

    1998-12-01

    The extent to which the onset of criminality with respect to heroin use accounts for heterogeneity within a heroin-using population was investigated among 400 community and incarcerated methadone maintenance patients. Those for whom crime preceded heroin use (primary antisocials) were younger and more likely to be male than those for whom heroin use preceded crime (secondary antisocials). Primary antisocials were also more likely to have committed violent crime and to qualify for a diagnosis of antisocial personality disorder (ASPD). It is concluded that taking the order of onset of heroin use and criminality into account may reduce the risk of overdiagnosing ASPD among this population and help clarify the relationship between drug use and crime.

  14. Assessing preferences about the DNR order: does it depend on how you ask?

    PubMed

    Percy, M E; Llewellyn-Thomas, H

    1995-01-01

    Despite increasing emphasis on advance directives, there has been little methodologic work to assess preferences about the "do not resuscitate" (DNR) order. This developmental work assessed, in a non-patient group, the performance of a probability-trade-off task designed to assess DNR attitudes, in terms of framing effects and stability of preferences. 105 female nursing students each completed one of two versions of the task. In version I (n = 58), the trade-off moved to increasingly negative descriptions of the outcomes of resuscitation (decreasing chance of survival and increasing risk of brain death), whereas in version II (n = 47), the trade-off moved to increasingly positive descriptions. One week later, repeat assessments were obtained for versions I (n = 35) and II (n = 28). The DNR preference scores were lower and more stable when the task moved to increasingly positive descriptions; perhaps this version of the task tends to weaken risk aversion. These results imply that care should be used in applying a probability trade-off task to the assessment of DNR preferences, since artefactual effects could be induced.

  15. Does the physician order-entry system increase the revenue of a general hospital?

    PubMed

    Park, Woong-Sub; Kim, Joon S; Chae, Young Moon; Yu, Seung-Hum; Kim, Chang-Yup; Kim, Sang-A; Jung, Sang Hyuk

    2003-08-01

    The purpose of this study was to examine whether the physician order-entry system (POE) could increase the outpatient and inpatient revenue of hospitals. We analyzed the inpatient and outpatient revenue data of all general hospitals (212) in South Korea obtained from the Korean National Health Insurance Corporation (KNHIC) during the period from 1996 to 1999 using the mixed model for repeated measure data. Analysis of the 4-years' panel data showed that both outpatient and inpatient revenues increased significantly after POE introduction. The hospital characteristics significantly influencing inpatient revenue were the number of beds, number of physicians and the tertiary status of a hospital; whereas those for outpatient revenue were the number of beds, number of physicians, the private status of a hospital, the tertiary status of a hospital and the urban status of a hospital. The revenues from both outpatients and inpatients were found to be increased after the introduction of the POE, while controlling for population size, competition, income, hospital location, hospital size, tertiary status and public status.

  16. Does order matter? Investigating the effect of sequence on glance duration during on-road driving.

    PubMed

    Lee, Joonbum; Roberts, Shannon C; Reimer, Bryan; Mehler, Bruce

    2017-01-01

    Previous literature has shown that vehicle crash risks increases as drivers' off-road glance duration increases. Many factors influence drivers' glance duration such as individual differences, driving environment, or task characteristics. Theories and past studies suggest that glance duration increases as the task progresses, but the exact relationship between glance sequence and glance durations is not fully understood. The purpose of this study was to examine the effect of glance sequence on glance duration among drivers completing a visual-manual radio tuning task and an auditory-vocal based multi-modal navigation entry task. Eighty participants drove a vehicle on urban highways while completing radio tuning and navigation entry tasks. Forty participants drove under an experimental protocol that required three button presses followed by rotation of a tuning knob to complete the radio tuning task while the other forty participants completed the task with one less button press. Multiple statistical analyses were conducted to measure the effect of glance sequence on glance duration. Results showed that across both tasks and a variety of statistical tests, glance sequence had inconsistent effects on glance duration-the effects varied according to the number of glances, task type, and data set that was being evaluated. Results suggest that other aspects of the task as well as interface design effect glance duration and should be considered in the context of examining driver attention or lack thereof. All in all, interface design and task characteristics have a more influential impact on glance duration than glance sequence, suggesting that classical design considerations impacting driver attention, such as the size and location of buttons, remain fundamental in designing in-vehicle interfaces.

  17. Does order matter? Investigating the effect of sequence on glance duration during on-road driving

    PubMed Central

    Roberts, Shannon C.; Reimer, Bryan; Mehler, Bruce

    2017-01-01

    Previous literature has shown that vehicle crash risks increases as drivers’ off-road glance duration increases. Many factors influence drivers’ glance duration such as individual differences, driving environment, or task characteristics. Theories and past studies suggest that glance duration increases as the task progresses, but the exact relationship between glance sequence and glance durations is not fully understood. The purpose of this study was to examine the effect of glance sequence on glance duration among drivers completing a visual-manual radio tuning task and an auditory-vocal based multi-modal navigation entry task. Eighty participants drove a vehicle on urban highways while completing radio tuning and navigation entry tasks. Forty participants drove under an experimental protocol that required three button presses followed by rotation of a tuning knob to complete the radio tuning task while the other forty participants completed the task with one less button press. Multiple statistical analyses were conducted to measure the effect of glance sequence on glance duration. Results showed that across both tasks and a variety of statistical tests, glance sequence had inconsistent effects on glance duration—the effects varied according to the number of glances, task type, and data set that was being evaluated. Results suggest that other aspects of the task as well as interface design effect glance duration and should be considered in the context of examining driver attention or lack thereof. All in all, interface design and task characteristics have a more influential impact on glance duration than glance sequence, suggesting that classical design considerations impacting driver attention, such as the size and location of buttons, remain fundamental in designing in-vehicle interfaces. PMID:28158301

  18. 12 CFR 1080.12 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 9 2014-01-01 2014-01-01 false Orders requiring witnesses to testify or provide other information and granting immunity. 1080.12 Section 1080.12 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION RULES RELATING TO INVESTIGATIONS § 1080.12 Orders requiring witnesses...

  19. 42 CFR 137.298 - Are Self-Governance Tribes required to comply with Executive Orders to fulfill their...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....298 Are Self-Governance Tribes required to comply with Executive Orders to fulfill their environmental... 42 Public Health 1 2010-10-01 2010-10-01 false Are Self-Governance Tribes required to comply with Executive Orders to fulfill their environmental responsibilities under section 509 of the Act ?...

  20. 48 CFR 8.405-2 - Ordering procedures for services requiring a statement of work.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... posted to GSA's electronic RFQ system, e-Buy (see 8.402(d)). (1) Orders at, or below, the micro-purchase threshold. Ordering activities may place orders at, or below, the micro-purchase threshold with any Federal... distribute orders among contractors. (2) For orders exceeding the micro-purchase threshold, but not...

  1. 48 CFR 8.405-2 - Ordering procedures for services requiring a statement of work.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... posted to GSA's electronic RFQ system, e-Buy (see 8.402(d)). (1) Orders at, or below, the micro-purchase threshold. Ordering activities may place orders at, or below, the micro-purchase threshold with any Federal... distribute orders among contractors. (2) For orders exceeding the micro-purchase threshold, but not...

  2. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  3. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  4. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  5. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  6. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  7. 24 CFR 1000.242 - When does the requirement for exemption from taxation apply to affordable housing activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... exemption from taxation apply to affordable housing activities? 1000.242 Section 1000.242 Housing and Urban... ACTIVITIES Indian Housing Plan (IHP) § 1000.242 When does the requirement for exemption from taxation apply to affordable housing activities? The requirement for exemption from taxation applies only to rental...

  8. 24 CFR 1000.242 - When does the requirement for exemption from taxation apply to affordable housing activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... exemption from taxation apply to affordable housing activities? 1000.242 Section 1000.242 Housing and Urban... ACTIVITIES Indian Housing Plan (IHP) § 1000.242 When does the requirement for exemption from taxation apply to affordable housing activities? The requirement for exemption from taxation applies only to rental...

  9. Does Order of Application of Emollient and Topical Corticosteroids Make a Difference in the Severity of Atopic Eczema in Children?

    PubMed

    Ng, Su Yuen; Begum, Sabeera; Chong, Sze Yee

    2016-01-01

    Atopic eczema (AE) is a common chronic inflammatory skin disorder in children, with emollients and topical corticosteroids (TCSs) commonly prescribed as treatment. There is no published guidance on the correct order of application of emollient and TCS in children with AE. The objective of this study was to determine whether the order of application of emollient and TCS makes a difference in the severity of AE in children. Forty-six patients ages 4 months to 5 years with moderate to severe AE were randomized to two groups: group A applied emollient followed by TCS 15 minutes later twice daily, and group B applied TCS followed by emollient 15 minutes later twice daily for 2 weeks. There was no statistically significant difference in the Eczema Area and Severity Index (EASI) score, percentage of body surface area (BSA) affected, or itch score between groups A and B (p > 0.05). Group A had statistically significant improvement in the EASI score, percentage BSA affected, and itch score from baseline to weeks 1 and 2; group B demonstrated statistically significant improvement only in the EASI score from baseline to week 1 and in itch score from baseline to week 2. There was no difference in adverse events between the groups. This study suggests that the order of application of emollient and TCS does not matter in the treatment of AE in children and that parents can apply topical medications in whichever order they prefer. © 2016 Wiley Periodicals, Inc.

  10. Mandatory continuing professional development requirements: what does this mean for Australian nurses.

    PubMed

    Ross, Kay; Barr, Jennieffer; Stevens, John

    2013-03-27

    This paper presents a discussion related to the recent decision in Australia to introduce mandatory Continuing Professional Development (CPD) for nurses. Historically there has been international debate surrounding mandatory CPD requirements; this debate is ongoing as Australian nurses face a diverse range of CPD offerings from a variety of providers. The purpose of this paper is to examine how mandatory CPD requirements for national nursing registration in Australia have evolved and to present an analysis of what this will mean for Australian nurses. What is yet to be determined is how to measure professional development and the effectiveness of professional development education. This is important to the international community with consensus in the literature that professional development is linked to ongoing education. Contradicting arguments are presented about whether this professional development should be mandatory. Presenting a contemporary discussion about the current and potential impact of mandatory CPD requirements for nurses, this discussion paper utilises the case of Australia's current national policy and CPD operation to examine the choices that nurses make in order to fulfil their legislative requirements. Additional arguments are presented about the barriers nurses face in undertaking CPD. The quest for effective CPD is complex and should incorporate different situations for nurses and individual learning styles.

  11. 48 CFR 8.405-2 - Ordering procedures for services requiring a statement of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (3) For proposed orders exceeding the maximum order threshold or when establishing a BPA. In addition... is reasonable. Place the order, or establish the BPA, with the schedule contractor that...

  12. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests, and... order to be kept secret. Records relating to matters that are specifically authorized under criteria established by an Executive order to be kept secret in the interest of national defense or foreign...

  13. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests, and... order to be kept secret. Records relating to matters that are specifically authorized under criteria established by an Executive order to be kept secret in the interest of national defense or foreign...

  14. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests, and... order to be kept secret. Records relating to matters that are specifically authorized under criteria established by an Executive order to be kept secret in the interest of national defense or foreign...

  15. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests, and... order to be kept secret. Records relating to matters that are specifically authorized under criteria established by an Executive order to be kept secret in the interest of national defense or foreign...

  16. 36 CFR 902.51 - Records relating to matters that are required by Executive order to be kept secret.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... that are required by Executive order to be kept secret. 902.51 Section 902.51 Parks, Forests, and... order to be kept secret. Records relating to matters that are specifically authorized under criteria established by an Executive order to be kept secret in the interest of national defense or foreign...

  17. Water Balance Modelling - Does The Required Model Complexity Change With Scale?

    NASA Astrophysics Data System (ADS)

    Blöschl, G.; Merz, R.

    An important issue in modelling the water balance of catchments is what is the suitable model complexity. Anecdotal evidence suggests that the model complexity required to model the water balance accurately decreases with catchment scale but so far very few studies have quantified these possible effects. In this paper we examine the model per- formance as a function of catchment scale for a given model complexity which allows us to infer, whether the required model complexity changes with scale. We also exam- ine whether the calibrated parameter values change with scale or are scale invariant. In a case study we analysed 700 catchments in Austria with catchment sizes ranging from 10 to 100 000 km2. 30 years of daily data (runoff, precipitation, air temperature, air humidity) were analysed. A spatially lumped, conceptual, HBV style soil mois- ture accounting scheme was used which involved fifteen model parameters including snow processes. Five parameters were preset and ten parameters were calibrated on observed daily streamflow. The calibration period was about 10 years and the verifi- cation period was about 20 years. Model performance (in terms of Nash-Sutcliffe effi- ciency) was examined both for the calibration and the verification periods. The mean efficiency over all catchments only decreased slightly when moving from the calibra- tion to the verification (from R2 = 0.65 to 0.60). The results suggest that the model efficiencies (both for the calibration and the verification) do not change which catch- ment scale for scales smaller than 10 000 km2 but beyond this scale there is a slight decrease in model performance. This means that for these very large scales, a spatial subdivision of the lumped model is needed to allow for spatial differences in rainfall. The results also suggest that the model parameters are not scale dependent. We con- clude that the complexity required for water balance models of catchments does not change with scale for catchment sizes

  18. Spatiotemporal requirements of the Hainan gibbon: Does home range constrain recovery of the world's rarest ape?

    PubMed

    Bryant, Jessica V; Zeng, Xingyuan; Hong, Xiaojiang; Chatterjee, Helen J; Turvey, Samuel T

    2017-03-01

    Conservation management requires an evidence-based approach, as uninformed decisions can signify the difference between species recovery and loss. The Hainan gibbon, the world's rarest ape, reportedly exploits the largest home range of any gibbon species, with these apparently large spatial requirements potentially limiting population recovery. However, previous home range assessments rarely reported survey methods, effort, or analytical approaches, hindering critical evaluation of estimate reliability. For extremely rare species where data collection is challenging, it also is unclear what impact such limitations have on estimating home range requirements. We re-evaluated Hainan gibbon spatial ecology using 75 hr of observations from 35 contact days over 93 field-days across dry (November 2010-February 2011) and wet (June 2011-September 2011) seasons. We calculated home range area for three social groups (N = 21 individuals) across the sampling period, seasonal estimates for one group (based on 24 days of observation; 12 days per season), and between-group home range overlap using multiple approaches (Minimum Convex Polygon, Kernel Density Estimation, Local Convex Hull, Brownian Bridge Movement Model), and assessed estimate reliability and representativeness using three approaches (Incremental Area Analysis, spatial concordance, and exclusion of expected holes). We estimated a yearly home range of 1-2 km(2) , with 1.49 km(2) closest to the median of all estimates. Although Hainan gibbon spatial requirements are relatively large for gibbons, our new estimates are smaller than previous estimates used to explain the species' limited recovery, suggesting that habitat availability may be less important in limiting population growth. We argue that other ecological, genetic, and/or anthropogenic factors are more likely to constrain Hainan gibbon recovery, and conservation attention should focus on elucidating and managing these factors. Re-evaluation reveals

  19. EVALUATION OF STATE-OF-THE-ART MANIPULATORS AND REQUIREMENTS FOR DOE ROBOTICS APPLICATIONS

    SciTech Connect

    BLACK, DEREK; GRUPINSKI, STEPHEN

    1998-10-08

    This report provides an overview of applications within the DOE complex which could benefit from the use of modular robotics technology during remediation operations. Each application area contains one or more specific tasks which are presently conducted by humans under hazardous conditions or which are deemed highly impractical, or are altogether impossible without automation. Five major areas were investigated for specific needs with respect to automation. Information was collected on Mixed Waste Operations, Contaminant Automated Analysis, Tanks, Decontamination and Dismantlement and Automated Plutonium Processing. During this investigation, information was gathered from available literature, telephone interviews with informed personnel and on-site visits. This data serves to provide design requirements and guidelines for the design of a family of modular actuators, which will be used to construct manipulators suited to each task. In addition, a survey of existing modular manipulator designs is presented. This survey addresses modular manipulators developed inside government labs and in universities for such applications as space exploration or controls research. It also addresses efforts at commercially viable industrial manipulators which have been built. This survey of robotic systems provides the reader with a glimpse into what technology currently exists in the way of modular manipulator automation and, to a degree, where this technology may be applicable or, more often, where these systems are unsuited to EM applications. From the information gathered during this study, it is possible to sufficiently define the requirements of one manipulator system which can be used to conduct automated transfer operations within Plutonium gloveboxes. This manipulator will be constructed from ARM Automation actuator modules and will provide this application with a viable option for automation within these gloveboxes. The design issues surrounding this manipulator and its

  20. Male sexual behavior does not require elevated testosterone in a lizard (Coleonyx elegans, Eublepharidae).

    PubMed

    Golinski, Alison; John-Alder, Henry; Kratochvíl, Lukáš

    2011-01-01

    Male sexual behavior depends on gonadal androgens in species of all major vertebrate lineages, including reptiles. However, male sexual behavior includes distinct appetitive and consummatory phases, typically denoted as courtship and mounting, with potentially different hormonal control. Different proximate controls of courtship versus mounting could enable disconnected evolutionary losses and gains of various aspects of male sexual behavior. Male courtship display, which is activated by testosterone (T) in many species, is an ancestral trait in the lizard family Eublepharidae. However, Coleonyx elegans (Yucatan Banded Gecko) lost the courtship display, while retaining a highly simplified male sexual behavior that involves only mounting for copulation. We performed surgical manipulations (castration with and without T replacement in adult males; implantation of adult females with exogenous T) to investigate hormonal mechanisms involved in this evolutionary novelty. Our results indicate that the expression of simplified sexual behavior in C. elegans does not require elevated circulating levels of T, a finding that is previously unreported in lizards. In females, however, exogenous T induced male-like mounting. Thus, the mounting phase of sexual behavior is not activated by T in the traditional sense of this term but probably requires post-natal, maturational organization (if not periodic reorganization) by androgens. We conclude that the simplification of male sexual behavior and its independence from elevated levels of circulating androgens in C. elegans evolved via 1) evolutionary loss of the androgen-activated courtship display and 2) retention of the mounting phase, which has a longer "functional memory" for the effects of androgenic steroids. Copyright © 2010 Elsevier Inc. All rights reserved.

  1. Sleep's Influence on a Reflexive Form of Memory That Does Not Require Voluntary Attention

    PubMed Central

    Sheth, Bhavin R.; Serranzana, Andrew; Anjum, Syed F.; Khan, Murtuza

    2012-01-01

    Study Objectives: Studies to date have examined the influence of sleep on forms of memory that require voluntary attention. The authors examine the influence of sleep on a form of memory that is acquired by passive viewing. Design: Induction of the McCollough effect, and measurement of perceptual color bias before and after induction, and before and after intervening sleep, wake, or visual deprivation. Setting: Sound-attenuated sleep research room. Participants: 13 healthy volunteers (mean age = 23 years; age range = 18–31 years) with normal or corrected-to-normal vision. Interventions: N/A. Measurements and Results:) Encoding: sleep preceded adaptation. On separate nights, each participant slept for an average of 0 (wake), 1, 2, 4, or 7 hr (complete sleep). Upon awakening, the participant's baseline perceptual color bias was measured. Then, he or she viewed an adapter consisting of alternating red/horizontal and green/vertical gratings for 5 min. Color bias was remeasured. The strength of the aftereffect is the postadaptation color bias relative to baseline. A strong orientation contingent color aftereffect was observed in all participants, but total sleep duration (TSD) prior to the adaptation did not modulate aftereffect strength. Further, prior sleep provided no benefit over prior wake. Retention: sleep followed adaptation. The procedure was similar except that adaptation preceded sleep. Postadaptation sleep, irrespective of its duration (1, 3, 5, or 7 hr), arrested aftereffect decay. By contrast, aftereffect decay was arrested during subsequent wake only if the adapted eye was visually deprived. Conclusions: Sleep as well as passive sensory deprivation enables the retention of a color aftereffect. Sleep shelters this reflexive form of memory in a manner akin to preventing sensory interference. Citation: Sheth BR; Serranzana A; Anjum SF; Khan M. Sleep's influence on a reflexive form of memory that does not require voluntary attention. SLEEP 2012

  2. Resistance exercise order does not affect the magnitude and duration of post-exercise blood pressure in older women.

    PubMed

    Tomeleri, Crisieli M; Nunes, João Pedro; Souza, Mariana F; Gerage, Aline; Marcori, Alexandre; Iarosz, Kessi Cassiane; Cardoso-Júnior, Crivaldo Gomes; Cyrino, Edilson S

    2017-08-15

    The aim of this study was to compare the effects of two resistance exercise order on post-exercise blood pressure (BP) in trained, non-hypertensive older women. Sixteen women (68.3 ± 3.3 years, 63.5 ± 11.6 kg, 157.5 ± 5.1 cm) performed two sessions witheight exercises (3 sets of 8-12 repetitions) in distinct orders (from multi- to single-joint exercises [MS] or from single- to multi-joint exercises [SM]) and a control session, without exercise. Blood pressure and heart rate were obtained pre and post-sessions (60 min). Post-exercise hypotension was observed for systolic and mean BP in both the MS session (systolic BP: -6.9 mmHg, mean BP: -3.3 mmHg, P< 0.05) and SM session (systolic BP: -4.6 mmHg; mean BP: -1.1 mmHg). Post-exercise heart rate was higher than pre-session values until 30 min of recovery in both training sessions. Furthermore, systolic and mean blood pressure, and heart rate were lower than the values obtained in the control session (30 to 60 min and 0 min, respectively; P<0.05). There were no differences between the SM and MS sessions in any variable or at any moment. In conclusion, resistance exercise order does not interfere in the magnitude and duration of post-exercise hypotension in trained, non-hypertensive older women.

  3. The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction.

    PubMed

    Timashev, Leonid A; Babcock, Hazen; Zhuang, Xiaowei; de Lange, Titia

    2017-03-15

    Telomeres are protected by shelterin, a six-subunit protein complex that represses the DNA damage response (DDR) at chromosome ends. Extensive data suggest that TRF2 in shelterin remodels telomeres into the t-loop structure, thereby hiding telomere ends from double-stranded break repair and ATM signaling, whereas POT1 represses ATR signaling by excluding RPA. An alternative protection mechanism was suggested recently by which shelterin subunits TRF1, TRF2, and TIN2 mediate telomeric chromatin compaction, which was proposed to minimize access of DDR factors. We performed superresolution imaging of telomeres in mouse cells after conditional deletion of TRF1, TRF2, or both, the latter of which results in the complete loss of shelterin. Upon removal of TRF1 or TRF2, we observed only minor changes in the telomere volume in most of our experiments. Upon codeletion of TRF1 and TRF2, the telomere volume increased by varying amounts, but even those samples exhibiting small changes in telomere volume showed DDR at nearly all telomeres. Upon shelterin removal, telomeres underwent 53BP1-dependent clustering, potentially explaining at least in part the apparent increase in telomere volume. Furthermore, chromatin accessibility, as determined by ATAC-seq (assay for transposase-accessible chromatin [ATAC] with high-throughput sequencing), was not substantially altered by shelterin removal. These results suggest that the DDR induced by shelterin removal does not require substantial telomere decompaction.

  4. TYLCV-Is movement in planta does not require V2 protein

    SciTech Connect

    Hak, Hagit; Levy, Yael; Chandran, Sam A.; Belausov, Eduard; Loyter, Abraham; Lapidot, Moshe; Gafni, Yedidya

    2015-03-15

    Tomato yellow leaf curl virus (TYLCV), a major tomato pathogen causing extensive crop losses, is a whitefly-transmitted geminivirus. V2 mutants of TYLCV-Is and related viruses tend to induce symptomless infection with attenuated viral DNA levels, while accumulating close to wild-type DNA levels in protoplasts, suggesting V2 as a movement protein. The discovery of plant-silencing mechanisms and viral silencing suppressors, V2 included, led us to reconsider V2's involvement in viral movement. We studied two mutant versions of the virus, one impaired in V2 silencing-suppression activity, and another carrying a non-translatable V2. While both mutant viruses spread in the infected plant to newly emerged leaves at the same rate as the wild-type virus, their DNA-accumulation levels were tenfold lower than in the wild-type virus. Thus, we suggest that the setback in virus proliferation, previously ascribed to a movement impediment, is due to lack of silencing-suppression activity. - Highlights: • TYLCV-Is V2 protein is localized in distinct microbodies throughout the cell cytoplasm, around the nucleus and in association with cytoplasmic strands but is not associated with the plasmodesmata. • Disruption of RNA-silencing suppression activity of TYLCV-Is V2 protein causes low titer of the virus in the infected plants. • The movement of TYLCV-Is in planta does not require a functional V2 protein.

  5. Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP.

    PubMed

    Lauer, Matthias E; Graff-Meyer, Alexandra; Rufer, Arne C; Maugeais, Cyrille; von der Mark, Elisabeth; Matile, Hugues; D'Arcy, Brigitte; Magg, Christine; Ringler, Philippe; Müller, Shirley A; Scherer, Sebastian; Dernick, Gregor; Thoma, Ralf; Hennig, Michael; Niesor, Eric J; Stahlberg, Henning

    2016-05-01

    The cholesteryl ester transfer protein (CETP) enables the transfer of cholesteryl ester (CE) from high-density lipoproteins (HDL) to low-density lipoproteins (LDL) in the plasma compartment. CETP inhibition raises plasma levels of HDL cholesterol; a ternary tunnel complex with CETP bridging HDL and LDL was suggested as a mechanism. Here, we test whether the inhibition of CETP tunnel complex formation is a promising approach to suppress CE transfer from HDL to LDL, for potential treatment of cardio-vascular disease (CVD). Three monoclonal antibodies against different epitopes of CETP are assayed for their potential to interfere with CE transfer between HDL and/or LDL. Surprisingly, antibodies that target the tips of the elongated CETP molecule, interaction sites sterically required to form the suggested transfer complexes, do not interfere with CETP activity, but an antibody binding to the central region does. We show that CETP interacts with HDL, but not with LDL. Our findings demonstrate that a ternary tunnel complex is not the mechanistic prerequisite to transfer CE among lipoproteins.

  6. Does the Chemical Diversity of the Order Haplosclerida (Phylum Porifera: Class Demospongia) Fit with Current Taxonomic Classification?

    PubMed

    Tribalat, Marie-Aude; Marra, Maria V; McCormack, Grace P; Thomas, Olivier P

    2016-06-01

    Sponges and their associated microbiota are well known to produce a large diversity of natural products, also called specialized metabolites. In addition to their potential use in the pharmaceutical industry, these rather species-specific compounds may help in the classification of some particular sponge groups. We review herein compounds isolated from haplosclerid sponges (Class Demospongia, Order Haplosclerida) in order to help in the revision of this large group of marine invertebrates. We focus only on 3-alkylpyridine derivatives and polyacetylenic compounds, as these two groups of natural products are characteristic of haplosclerid species and are highly diverse. A close collaboration between chemists and biologists is required in order to fully apply chemotaxonomical approaches, and whenever possible biological data should include morphological and molecular data and some insight into their microbial abundance. Georg Thieme Verlag KG Stuttgart · New York.

  7. 20 CFR 653.501 - Requirements for accepting and processing clearance orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... clearance orders. 653.501 Section 653.501 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... clearance any job order seeking workers to perform agricultural or food processing work before reviewing it... order seeking workers to perform agricultural or food processing work into intrastate clearance unless...

  8. 20 CFR 10.909 - How does an employee designate a variation in the order or percentage of gratuity payable to...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false How does an employee designate a variation in...' COMPENSATION ACT, AS AMENDED Death Gratuity § 10.909 How does an employee designate a variation in the order or...) Form CA-40 must be used to make a variation in the order or percentages of survivors under § 10.907 and...

  9. Nurse honeybee workers tend capped-brood, which does not require feeding, around-the-clock.

    PubMed

    Nagari, Moshe; Brenner, Yafit; Bloch, Guy

    2017-09-14

    "Nurse" honeybees tend brood around-the-clock with attenuated or no circadian rhythms, but the brood signals inducing this behavior remain elusive. We first tested the hypothesis that worker circadian rhythms are regulated by brood pheromones. We monitored locomotor activity of individually isolated nurse bees that were either exposed to various doses of larval extracts or synthetic brood ester pheromone (BEP). Bees orally treated with larvae extracts showed attenuated circadian rhythms in one of four tested colonies; a similar but statistically non-significant trend was seen in two additional colonies. Nurse bees treated with synthetic BEP showed rhythm attenuation in one of three tested colonies. Next, we tested the hypothesis that capped brood, which does not require feeding, nevertheless induces around-the-clock activity in nurses. By combining a new protocol that enables brood care by individually isolated nurse bees, detailed behavioral observations, and automatic high resolution monitoring of locomotor activity, we found that isolated nurses tended capped brood around-the-clock with attenuated circadian rhythms. Bees individually isolated in similar cages but without brood, showed strong circadian rhythms in locomotor activity and rest. This study shows for the first time that the need to feed hungry larvae is not the only factor accounting for around-the-clock activity in nurse bees. Our results further suggest that the transition between activity with and without circadian rhythms is not a simple switch triggered by brood pheromones. Around-the-clock tending may enhance brood development and health in multiple ways that may include improved larval feeding, thermoregulation and hygienic behavior. © 2017. Published by The Company of Biologists Ltd.

  10. Transgastric endoscopic peritoneoscopy does not require decontamination of the stomach in humans.

    PubMed

    Narula, Vimal K; Happel, Lynn C; Volt, Kevin; Bergman, Simon; Roland, Jason C; Dettorre, Rebecca; Renton, David B; Reavis, Kevin M; Needleman, Bradley J; Mikami, Dean J; Ellison, E Christopher; Melvin, W Scott; Hazey, Jeffrey W

    2009-06-01

    Natural orifice translumenal endoscopic surgery (NOTES) is a rapidly evolving field that provides endoscopic access to the peritoneum via a natural orifice. One important requirement of this technique is the need to minimize the risk of clinically significant peritoneal contamination. We report the bacterial load and contamination of the peritoneal cavity in ten patients who underwent diagnostic transgastric endoscopic peritoneoscopy. Patients participating in this trial were scheduled to undergo diagnostic laparoscopy for evaluation of presumed pancreatic cancer. Findings at diagnostic laparoscopy were compared with those of diagnostic transgastric endoscopic peritoneoscopy, using an orally placed gastroscope, blinding the endoscopist to the laparoscopic findings. We performed no gastric decontamination. Diagnostic findings, operative times, and clinical course were recorded. Gastroscope and peritoneal fluid aspirates were obtained prior to and after the gastrotomy. Each sample was sent for bacterial colony counts, culture, and identification of species. Ten patients, with an average age of 63.7 years, have completed the protocol. All patients underwent diagnostic laparoscopy followed by successful transgastric access and diagnostic peritoneoscopy. The average time for laparoscopy was 7.2 min, compared with 18 min for transgastric instrumentation. Bacterial sampling was obtained in all ten patients. The average number of colony-forming units (CFU) in the gastroscope aspirate was 132.1 CFU/ml, peritoneal aspirates prior to creation of a gastrotomy showed 160.4 CFU/ml, and peritoneal sampling after gastrotomy had an average of 642.1 CFU/ml. There was no contamination of the peritoneal cavity with species isolated from the gastroscope aspirate. No infectious complications or leaks were noted at 30-day follow-up. There was no clinically significant contamination of the peritoneal cavity from the gastroscope after transgastric endoscopic instrumentation in humans

  11. Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis

    PubMed Central

    Lucena-Agell, Daniel; Galindo, Antonio; Arst, Herbert N.

    2015-01-01

    Aspergillus nidulans (Pal) ambient pH signaling takes place in cortical structures containing components of the ESCRT pathway, which are hijacked by the alkaline pH-activated, ubiquitin-modified version of the arrestin-like protein PalF and taken to the plasma membrane. There, ESCRTs scaffold the assembly of dedicated Pal proteins acting downstream. The molecular details of this pathway, which results in the two-step proteolytic processing of the transcription factor PacC, have received considerable attention due to the key role that it plays in fungal pathogenicity. While current evidence strongly indicates that the pH signaling role of ESCRT complexes is limited to plasma membrane-associated structures where PacC proteolysis would take place, the localization of the PalB protease, which almost certainly catalyzes the first and only pH-regulated proteolytic step, had not been investigated. In view of ESCRT participation, this formally leaves open the possibility that PalB activation requires endocytic internalization. As endocytosis is essential for hyphal growth, nonlethal endocytic mutations are predicted to cause an incomplete block. We used a SynA internalization assay to measure the extent to which any given mutation prevents endocytosis. We show that none of the tested mutations impairing endocytosis to different degrees, including slaB1, conditionally causing a complete block, have any effect on the activation of the pathway. We further show that PalB, like PalA and PalC, localizes to cortical structures in an alkaline pH-dependent manner. Therefore, signaling through the Pal pathway does not involve endocytosis. PMID:25841020

  12. Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?

    PubMed

    Yakar, Fatih; Yakar, Aysun; Büyükpınarbaşılı, Nur; Erelel, Mustafa

    2016-04-11

    BACKGROUND Lung cancer and tuberculosis (TB) are two major public health problems. They can coexist or appear sequentially. In patients with TB, lung cancer risk is increased. However, vice versa is not crystal clear. In this study, we aimed to determine the development of TB in patients with resectabled non-small cell lung cancer (NSCLC) in a 2-year postoperative follow-up period. MATERIAL AND METHODS We conducted a retrospective cohort study at three university hospitals. Patients who had NSCLC surgery between 2009 and 2013 were included and patient records were reviewed for the presence of necrotizing granulomatous inflammation (NGI) in resected specimens. Demographic properties, tumor type, stage, location, type of surgery, tuberculosis history, and thorax CT findings were recorded. We searched for the development of tuberculosis within a 2-year period after surgery. RESULTS A total of 1027 patient cases were reviewed, of which 48 patients had NGI. The median age was 63 years. The most common type of cancer was squamous carcinoma; and lobectomy was the preferred operation (70.8%). Cancer involvement most commonly included the right lung (61.8%) and upper lobes (47,9%). Only 11 patients had anti-TB treatment postoperatively, which was based on radiological findings. Prior tuberculosis or anti-TB history, type, stage or localization of cancer, and adjuvant/neoadjuvant therapy were not found to be related to TB treatment. None of the study population had TB during the two-year follow-up period. Treatment decisions appeared mostly related to physician experience. There was no difference in the risk of developing TB between patients with or without treatment. This finding may change the management of our patients. CONCLUSIONS Every NGI discovered in NSCLC resected material does not always require anti-TB treatment.

  13. Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active site.

    PubMed

    Roberts, Kenneth M; Khan, Crystal A; Hinck, Cynthia S; Fitzpatrick, Paul F

    2014-12-16

    Phenylalanine hydroxylase (PheH), a liver enzyme that catalyzes the hydroxylation of excess phenylalanine in the diet to tyrosine, is activated by phenylalanine. The lack of activity at low levels of phenylalanine has been attributed to the N-terminus of the protein's regulatory domain acting as an inhibitory peptide by blocking substrate access to the active site. The location of the site at which phenylalanine binds to activate the enzyme is unknown, and both the active site in the catalytic domain and a separate site in the N-terminal regulatory domain have been proposed. Binding of catecholamines to the active-site iron was used to probe the accessibility of the active site. Removal of the regulatory domain increases the rate constants for association of several catecholamines with the wild-type enzyme by ∼2-fold. Binding of phenylalanine in the active site is effectively abolished by mutating the active-site residue Arg270 to lysine. The k(cat)/K(phe) value is down 10⁴ for the mutant enzyme, and the K(m) value for phenylalanine for the mutant enzyme is >0.5 M. Incubation of the R270K enzyme with phenylalanine also results in a 2-fold increase in the rate constants for catecholamine binding. The change in the tryptophan fluorescence emission spectrum seen in the wild-type enzyme upon activation by phenylalanine is also seen with the R270K mutant enzyme in the presence of phenylalanine. Both results establish that activation of PheH by phenylalanine does not require binding of the amino acid in the active site. This is consistent with a separate allosteric site, likely in the regulatory domain.

  14. 45 CFR 286.230 - What if a Tribe does not have reasonable cause for failing to meet a requirement?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What if a Tribe does not have reasonable cause for failing to meet a requirement? 286.230 Section 286.230 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  15. 41 CFR 102-118.25 - Does GSA still require my agency to submit its overall transportation policies for approval?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT General Introduction... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does GSA still require...

  16. 43 CFR 2568.40 - Does BLM have the authority to ask me for the information required in these regulations?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Does BLM have the authority to ask me for the information required in these regulations? 2568.40 Section 2568.40 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND...

  17. 43 CFR 2568.40 - Does BLM have the authority to ask me for the information required in these regulations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Does BLM have the authority to ask me for the information required in these regulations? 2568.40 Section 2568.40 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND...

  18. 43 CFR 2568.40 - Does BLM have the authority to ask me for the information required in these regulations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Does BLM have the authority to ask me for the information required in these regulations? 2568.40 Section 2568.40 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND...

  19. 43 CFR 2568.40 - Does BLM have the authority to ask me for the information required in these regulations?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Does BLM have the authority to ask me for the information required in these regulations? 2568.40 Section 2568.40 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND...

  20. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  1. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  2. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  3. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  4. 34 CFR 461.44 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false How does a State request a waiver of the maintenance of effort requirement? 461.44 Section 461.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION...

  5. 34 CFR 461.44 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false How does a State request a waiver of the maintenance of effort requirement? 461.44 Section 461.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION...

  6. 34 CFR 461.44 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false How does a State request a waiver of the maintenance of effort requirement? 461.44 Section 461.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION...

  7. 34 CFR 461.44 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false How does a State request a waiver of the maintenance of effort requirement? 461.44 Section 461.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT...

  8. 25 CFR 1000.396 - Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for Tribe/Consortium management systems? 1000.396 Section 1000.396... minimum standards for Tribe/Consortium management systems? Yes, the Tribe/Consortium must...

  9. 25 CFR 1000.396 - Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for Tribe/Consortium management systems? 1000.396 Section 1000.396... minimum standards for Tribe/Consortium management systems? Yes, the Tribe/Consortium must...

  10. 25 CFR 1000.396 - Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for Tribe/Consortium management systems? 1000.396 Section 1000.396... minimum standards for Tribe/Consortium management systems? Yes, the Tribe/Consortium must...

  11. 25 CFR 1000.396 - Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Does a Tribe/Consortium have additional ongoing requirements to maintain minimum standards for Tribe/Consortium management systems? 1000.396 Section 1000.396... minimum standards for Tribe/Consortium management systems? Yes, the Tribe/Consortium must...

  12. 14 CFR 382.97 - To which aircraft does the requirement to provide boarding and deplaning assistance through the...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false To which aircraft does the requirement to... Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL REGULATIONS NONDISCRIMINATION ON THE BASIS OF DISABILITY IN AIR TRAVEL Boarding, Deplaning, and...

  13. DOE Review of Requirements and Capabilities for Analyzing and Responding to BDBEs

    SciTech Connect

    None, None

    2011-08-01

    The U.S. Department of Energy (DOE) has established a rigorous nuclear safety regulatory infrastructure for the protection of workers, the public, and the environment. Part of this infrastructure includes processes for evaluating events to foster continuous improvement. In this spirit, DOE (including the National Nuclear Security Administration) took the following actions to review the safety of its nuclear facilities and identify opportunities for improvement in light of the March 2011 accident at the Fukushima Daiichi nuclear power plant.

  14. 78 FR 64408 - Watermelon Research and Promotion Plan; Importer Membership Requirements and Referendum Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 1210 Watermelon Research and Promotion... Watermelon Research and Promotion Plan (Plan) importer membership requirements to serve on the National Watermelon Promotion Board (Board). The Board recommended eliminating the requirement that an importer...

  15. The Knotted Sky II: does BICEP2 require a nontrivial primordial power spectrum?

    SciTech Connect

    Abazajian, Kevork N.; Aslanyan, Grigor; Easther, Richard; Price, Layne C. E-mail: g.aslanyan@auckland.ac.nz E-mail: lpri691@aucklanduni.ac.nz

    2014-08-01

    An inflationary gravitational wave background consistent with BICEP2 is difficult to reconcile with a simple power-law spectrum of primordial scalar perturbations. Tensor modes contribute to the temperature anisotropies at multipoles with l∼< 100, and this effect — together with a prior on the form of the scalar perturbations — was the source of previous bounds on the tensor-to-scalar ratio. We compute Bayesian evidence for combined fits to BICEP2 and Planck for three nontrivial primordial spectra: a) a running spectral index, b) a cutoff at fixed wavenumber, and c) a spectrum described by a linear spline with a single internal knot. We find no evidence for a cutoff, weak evidence for a running index, and significant evidence for a ''broken'' spectrum. Taken at face-value, the BICEP2 results require two new inflationary parameters in order to describe both the broken scale invariance in the perturbation spectrum and the observed tensor-to-scalar ratio. Alternatively, this tension may be resolved by additional data and more detailed analyses.

  16. Does Pilocarpine-Induced Epilepsy in Adult Rats Require Status epilepticus?

    PubMed Central

    Navarro Mora, Graciela; Bramanti, Placido; Osculati, Francesco; Chakir, Asmaa; Nicolato, Elena; Marzola, Pasquina; Sbarbati, Andrea; Fabene, Paolo Francesco

    2009-01-01

    Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy. Some evidences reported in the literature suggest that at least 1 h of status epilepticus (SE) is required to produce subsequent chronic phase, due to the SE-related acute neuronal damage. However, recent data seems to indicate that neuro-inflammation plays a crucial role in epileptogenesis, modulating secondarily a neuronal insult. For this reason, we decided to test the following hypotheses: a) whether pilocarpine-injected rats that did not develop SE can exhibit long-term chronic spontaneous recurrent seizures (SRS) and b) whether acute neurodegeneration is mandatory to obtain chronic epilepsy. Therefore, we compared animals injected with the same dose of pilocarpine that developed or did not SE, and saline treated rats. We used telemetric acquisition of EEG as long-term monitoring system to evaluate the occurrence of seizures in non-SE pilocarpineinjected animals. Furthermore, histology and MRI analysis were applied in order to detect neuronal injury and neuropathological signs. Our observations indicate that non-SE rats exhibit SRS almost 8 (+/22) months after pilocarpine-injection, independently to the absence of initial acute neuronal injury. This is the first time reported that pilocarpine injected rats without developing SE, can experience SRS after a long latency period resembling human pathology. Thus, we strongly emphasize the important meaning of including these animals to model human epileptogenesis in pilocarpine induced epilepsy. PMID:19503612

  17. A DOE contractor`s perspective of environmental monitoring requirements at a low-level waste facility

    SciTech Connect

    Ferns, T.W.

    1989-11-01

    Environmental monitoring at a low-level waste disposal facility (LLWDF) should, (1) demonstrate compliance with environmental laws; (2) detect any spatial or temporal environmental changes; and (3) provide information on the potential or actual exposure of humans and/or the environment to disposed waste and/or waste by-products. Under the DOE Order system the LLWDF site manager has more freedom of implementation for a monitoring program than either the semi-prescriptive NRC, or the prescriptive EPA hazardous waste programs. This paper will attempt to compare and contrast environmental monitoring under the different systems (DOE, NRC, and EPA), and determine if the DOE might benefit from a more prescriptive system.

  18. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M.; Hemenway, A.

    1991-12-31

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  19. The Clean Air Act Amendments of 1990: Hazardous Air Pollutant Requirements and the DOE Clean Coal Technology Program

    SciTech Connect

    Moskowitz, P.D.; DePhillips, M.; Fthenakis, V.M. ); Hemenway, A. )

    1991-01-01

    The purpose of the US Department of Energy -- Office of Fossil Energy (DOE FE) Clean Coal Technology Program (CCTP) is to provide the US energy marketplace with advanced, efficient, and environmentally sound coal-based technologies. The design, construction, and operation of Clean Coal Technology Demonstration Projects (CCTDP) will generate data needed to make informed, confident decisions on the commercial readiness of these technologies. These data also will provide information needed to ensure a proactive response by DOE and its industrial partners to the establishment of new regulations or a reactive response to existing regulations promulgated by the US Environmental Protection Agency (EPA). The objectives of this paper are to: (1) Present a preliminary examination of the potential implications of the Clean Air Act Amendments (CAAA) -- Title 3 Hazardous Air Pollutant requirements to the commercialization of CCTDP; and (2) help define options available to DOE and its industrial partners to respond to this newly enacted Legislation.

  20. 21 CFR 1311.50 - Requirements for recipients of digitally signed orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... signed. (3) Check the validity of the certificate holder's certificate by checking the Certificate Revocation List. (4) Check the certificate extension data to determine whether the sender has the authority to order the controlled substance. (b) A recipient may cache Certificate Revocation Lists for...

  1. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Discovery and...) Issuance of protective order. Upon motion by a party or by the person from whom discovery is sought or by..., or undue burden or expense, including one or more of the following: (1) That discovery not be had;...

  2. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Discovery and...) Issuance of protective order. Upon motion by a party or by the person from whom discovery is sought or by..., or undue burden or expense, including one or more of the following: (1) That discovery not be had;...

  3. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Discovery and...) Issuance of protective order. Upon motion by a party or by the person from whom discovery is sought or by..., or undue burden or expense, including one or more of the following: (1) That discovery not be had;...

  4. 41 CFR 102-3.185 - What does this subpart require agencies to do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Academy of Sciences or the National Academy of Public Administration? § 102-3.185 What does this... recommendation provided to an agency by the National Academy of Sciences (NAS) or the National Academy of Public Administration (NAPA) under an agreement between the agency and an academy, if such advice or recommendation was...

  5. 40 CFR 763.122 - What does this subpart require me to do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos Worker Protection § 763.122 What does this subpart... standards in 29 CFR 1910.1001. (c) Repair, cleaning, or replacement of asbestos-containing clutch plates and brake pads, shoes, and linings, or removal of asbestos-containing residue from brake drums or clutch...

  6. 49 CFR 23.77 - Does this part preempt local requirements?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirements? (a) In the event that a State or local law, regulation, or policy differs from the requirements...'s, or disadvantaged business enterprise concerning airport concessions that adds to, goes beyond, or...

  7. Improvement in appropriate utilization of recombinant human erythropoietin pre- and post-implementation of a required order form.

    PubMed

    Burns, Tammy L; Ferry, Brenna A; Malesker, Mark A; Morrow, Lee E; Bruckner, Anne L; Lee, Debra L

    2010-05-01

    Erythropoietin stimulating agents (ESAs) are high-cost medications that have a significant impact on many pharmacy budgets. Recently, ESAs have received stronger safety warnings and reimbursement has been curtailed by third-party payers including the Centers for Medicare and Medicaid Services. For these reasons, many hospitals are developing strategies to optimize their use. A required order form with acceptable indications and dosing was implemented at an academic medical center in an attempt to improve dosing and appropriate utilization of ESAs. To determine whether implementation of a required order form increased appropriate use and/or decreased total utilization of recombinant human erythropoietin (rHuEPO). This was a retrospective cohort study of rHuEPO utilization for 4 months pre- and 6 months post-implementation (April 2008-January 2009). Implementation of a required order form for rHuEPO resulted in significantly fewer patients receiving inappropriate doses of rHuEPO (51.3% vs 19.2%, p < 0.001). The number of patients treated, adjusted to hospital census, was also reduced after implementation of the order form (0.003 vs 0.004 pts./average pt. days, p = 0.03). Annual spending for rHuEPO was reduced by 47% during 2008 despite an increased acquisition cost. Implementation of a required order form with evidence-based dosing recommendations can be an effective strategy to improve appropriate utilization of rHuEPO.

  8. 18 CFR 35.19a - Refund requirements under suspension orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... percent simple interest per annum on all excessive rates or charges held prior to October 10, 1974; (ii) At a rate of nine percent simple interest per annum on all excessive rates or charges held between... justified, together with interest as required in paragraph (a)(2) of this section. (2) Interest shall be...

  9. 18 CFR 35.19a - Refund requirements under suspension orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... percent simple interest per annum on all excessive rates or charges held prior to October 10, 1974; (ii) At a rate of nine percent simple interest per annum on all excessive rates or charges held between... justified, together with interest as required in paragraph (a)(2) of this section. (2) Interest shall be...

  10. 18 CFR 35.19a - Refund requirements under suspension orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... percent simple interest per annum on all excessive rates or charges held prior to October 10, 1974; (ii) At a rate of nine percent simple interest per annum on all excessive rates or charges held between... justified, together with interest as required in paragraph (a)(2) of this section. (2) Interest shall be...

  11. 18 CFR 35.19a - Refund requirements under suspension orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... percent simple interest per annum on all excessive rates or charges held prior to October 10, 1974; (ii) At a rate of nine percent simple interest per annum on all excessive rates or charges held between... justified, together with interest as required in paragraph (a)(2) of this section. (2) Interest shall be...

  12. 18 CFR 35.19a - Refund requirements under suspension orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... percent simple interest per annum on all excessive rates or charges held prior to October 10, 1974; (ii) At a rate of nine percent simple interest per annum on all excessive rates or charges held between... justified, together with interest as required in paragraph (a)(2) of this section. (2) Interest shall be...

  13. Sustainable institutionalized punishment requires elimination of second-order free-riders

    NASA Astrophysics Data System (ADS)

    Perc, Matjaž

    2012-03-01

    Although empirical and theoretical studies affirm that punishment can elevate collaborative efforts, its emergence and stability remain elusive. By peer-punishment the sanctioning is something an individual elects to do depending on the strategies in its neighborhood. The consequences of unsustainable efforts are therefore local. By pool-punishment, on the other hand, where resources for sanctioning are committed in advance and at large, the notion of sustainability has greater significance. In a population with free-riders, punishers must be strong in numbers to keep the ``punishment pool'' from emptying. Failure to do so renders the concept of institutionalized sanctioning futile. We show that pool-punishment in structured populations is sustainable, but only if second-order free-riders are sanctioned as well, and to a such degree that they cannot prevail. A discontinuous phase transition leads to an outbreak of sustainability when punishers subvert second-order free-riders in the competition against defectors.

  14. Sustainable institutionalized punishment requires elimination of second-order free-riders

    PubMed Central

    Perc, Matjaž

    2012-01-01

    Although empirical and theoretical studies affirm that punishment can elevate collaborative efforts, its emergence and stability remain elusive. By peer-punishment the sanctioning is something an individual elects to do depending on the strategies in its neighborhood. The consequences of unsustainable efforts are therefore local. By pool-punishment, on the other hand, where resources for sanctioning are committed in advance and at large, the notion of sustainability has greater significance. In a population with free-riders, punishers must be strong in numbers to keep the “punishment pool” from emptying. Failure to do so renders the concept of institutionalized sanctioning futile. We show that pool-punishment in structured populations is sustainable, but only if second-order free-riders are sanctioned as well, and to a such degree that they cannot prevail. A discontinuous phase transition leads to an outbreak of sustainability when punishers subvert second-order free-riders in the competition against defectors. PMID:22468228

  15. Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order.

    PubMed

    Magenau, Astrid; Benzing, Carola; Proschogo, Nicholas; Don, Anthony S; Hejazi, Leila; Karunakaran, Denuja; Jessup, Wendy; Gaus, Katharina

    2011-12-01

    The biochemical composition and biophysical properties of cell membranes are hypothesized to affect cellular processes such as phagocytosis. Here, we examined the plasma membranes of murine macrophage cell lines during the early stages of uptake of immunoglobulin G (IgG)-coated polystyrene particles. We found that the plasma membrane undergoes rapid actin-independent condensation to form highly ordered phagosomal membranes, the biophysical hallmark of lipid rafts. Surprisingly, these membranes are depleted of cholesterol and enriched in sphingomyelin and ceramide. Inhibition of sphingomyelinase activity impairs membrane condensation, F-actin accumulation at phagocytic cups and particle uptake. Switching phagosomal membranes to a cholesterol-rich environment had no effect on membrane condensation and the rate of phagocytosis. In contrast, preventing membrane condensation with the oxysterol 7-ketocholesterol, even in the presence of ceramide, blocked F-actin dissociation from nascent phagosomes and particle uptake. In conclusion, our results suggest that ordered membranes function to co-ordinate F-actin remodelling and that the biophysical properties of phagosomal membranes are essential for phagocytosis. © 2011 John Wiley & Sons A/S.

  16. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  17. 12 CFR 1080.12 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 1080.12 Section 1080.12 Banks and Banking BUREAU OF... testify or provide other information and granting immunity. (a) The Assistant Director of the Division of... issuance of an order requiring a witness to testify or provide other information granting immunity under...

  18. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  19. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  20. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  1. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  2. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  3. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  4. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  5. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  6. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  7. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  8. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  9. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  10. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  11. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  12. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity...

  13. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  14. 16 CFR 1025.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 1025.39 Section 1025.39 Commercial Practices CONSUMER... Process § 1025.39 Orders requiring witnesses to testify or provide other information and granting immunity... witness or deponent to testify or provide other information upon being granted immunity from...

  15. 49 CFR 511.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... other information and granting immunity. 511.39 Section 511.39 Transportation Other Regulations Relating... testify or provide other information and granting immunity. (a) A party who desires the issuance of an order requiring a witness to testify or provide other information upon being granted immunity...

  16. 16 CFR 3.39 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... provide other information and granting immunity. 3.39 Section 3.39 Commercial Practices FEDERAL TRADE... granting immunity. (a) Where Commission complaint counsel desire the issuance of an order requiring a witness or deponent to testify or provide other information and granting immunity under 18 U.S.C....

  17. 21 CFR 1311.30 - Requirements for storing and using a private key for digitally signing orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Requirements for storing and using a private key for digitally signing orders. 1311.30 Section 1311.30 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION... private key. (b) The certificate holder must provide FIPS-approved secure storage for the private key, as...

  18. 34 CFR 222.63 - What other requirements must a local educational agency meet in order to be eligible for...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... meet in order to be eligible for financial assistance under section 8003(f)(2)(A)? 222.63 Section 222... Local Educational Agencies Under Section 8003(f) of the Act § 222.63 What other requirements must a...)(A)? Subject to § 222.65, an LEA described in § 222.62(a), (b), or (c) is eligible for...

  19. 34 CFR 222.64 - What other requirements must a local educational agency meet in order to be eligible for...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... meet in order to be eligible for financial assistance under section 8003(f)(2)(B)? 222.64 Section 222... Local Educational Agencies Under Section 8003(f) of the Act § 222.64 What other requirements must a...)(B)? Subject to § 222.65, an LEA described in § 222.62(d) is eligible for financial assistance...

  20. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Ordering procedures for... Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND... surveying at least three schedule contractors through the GSA Advantage! on-line shopping service,...

  1. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Ordering procedures for... Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND... surveying at least three schedule contractors through the GSA Advantage! on-line shopping service,...

  2. Does adding low doses of oral naltrexone to morphine alter the subsequent opioid requirements and side effects in trauma patients?

    PubMed

    Farahmand, Shervin; Ahmadi, Omid; Dehpour, Ahmadreza; Khashayar, Patricia

    2012-01-01

    The present study aims to assess the influence of ultra-low doses of opioid antagonists on the analgesic properties of opioids and their side effects. In the present randomized, double-blind controlled trial, the influence of the combination of ultra-low-dose naltrexone and morphine on the total opioid requirement and the frequency of the subsequent side effects was compared with that of morphine alone (added with placebo) in patients with trauma in the upper or lower extremities. Although the morphine and naltrexone group required 0.04 mg more opioids during the study period, there was no significant difference between the opioid requirements of the 2 groups. Nausea was less frequently reported in patients receiving morphine and naltrexone. The combination of ultra-low-dose naltrexone and morphine in extremity trauma does not affect the opioid requirements; it, however, lowers the risk of nausea. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... eligibility, including donor screening and testing. The requirements contained in this subpart are a component... on donor screening and testing for relevant communicable disease agents and diseases, is required for... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45...

  4. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... eligibility, including donor screening and testing. The requirements contained in this subpart are a component... on donor screening and testing for relevant communicable disease agents and diseases, is required for... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45...

  5. 43 CFR 428.7 - What happens if a farm operator does not submit required forms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR INFORMATION REQUIREMENTS FOR CERTAIN FARM OPERATIONS IN EXCESS OF 960 ACRES AND THE ELIGIBILITY OF CERTAIN FORMERLY EXCESS LAND § 428.7 What happens if a farm..., then: (1) The district must not deliver irrigation water before you submit the required RRA...

  6. Students' Self-Assessment in Chemistry Examinations Requiring Higher- and Lower-Order Cognitive Skills

    NASA Astrophysics Data System (ADS)

    Zoller*, Uri; Fastow, Michal; Lubezky, Aviva; Tsaparlis, Georgios

    1999-01-01

    The development of students' higher-order cognitive skills (HOCS) in the context of both chemistry and the complex interrelationships of science, technology, environment, and society is widely accepted as one of the most important goals of chemical education. Consequently, the translation of this goal into teaching, assessment, and learning strategies is a central issue in chemistry teaching. Students' self-assessment in chemistry examinations is a HOCS-promoting strategy. We evaluated the differences between students' self-assessment and their professors' assessment on midterm exams in introductory college courses in Israel and Greece, together with the students' appraisal of their capability for self- and peer-assessment. We found that (i) there were small (not significant) and large (significant) differences between students' self-grading and their professors' grading on LOCS and HOCS exam questions, respectively; (ii) students' estimates of their grades were higher than those of their professors, particularly for HOCS questions; and (iii) students believed that they were capable of self- and peer-assessment and were confident in making these assessments. Our results suggest that (i) students' self-assessment of LOCS-type exams can be successfully implemented immediately, whereas (ii) implementation of self-assessment for HOCS-type exam questions should be gradual, following appropriate preparation to close the gap between the future HOCS and contemporary dominant LOCS orientations in chemistry teaching and learning.

  7. 13 CFR 123.11 - Does SBA require collateral for any of its disaster loans?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... appropriate in the event the President declares a major disaster), or an economic injury disaster loan of $5... loan after a single disaster. In deciding whether collateral is required, SBA will add up all physical...

  8. 43 CFR 2932.44 - What bonds does BLM require for a Special Recreation Permit?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... RECREATION ON PUBLIC LANDS Special Recreation Permits for Commercial Use, Competitive Events, Organized... Recreation Permit? BLM may require you to submit a payment bond, a cash or surety deposit, or other financial...

  9. Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA

    PubMed Central

    Álvarez, Vanesa; Viñas, Laura; Gallego-Sánchez, Alfonso; Andrés, Sonia; Sacristán, María P.; Bueno, Avelino

    2016-01-01

    Proliferating-cell nuclear antigen (PCNA) is a DNA sliding clamp with an essential function in DNA replication and a key role in tolerance to DNA damage by ensuring the bypass of lesions. In eukaryotes, DNA damage tolerance is regulated by ubiquitylation of lysine 164 of PCNA through a well-known control mechanism; however, the regulation of PCNA deubiquitylation remains poorly understood. Our work is a systematic and functional study on PCNA deubiquitylating enzymes (DUBs) in Schizosaccharomyces pombe. Our study reveals that the deubiquitylation of PCNA in fission yeast cells is a complex process that requires several ubiquitin proteases dedicated to the deubiquitylation of a specific subnuclear fraction of mono- and di-ubiquitylated PCNA or a particular type of poly-ubiquitylated PCNA and that there is little redundancy among these enzymes. To understand how DUB activity regulates the oscillatory pattern of ubiquitylated PCNA in fission yeast, we assembled multiple DUB mutants and found that a quadruple mutation of ubp2+, ubp12+, ubp15+, and ubp16+ leads to the stable accumulation of mono-, di-, and poly-ubiquitylated forms of PCNA, increases S-phase duration, and sensitizes cells to DNA damage. Our data suggest that the dynamic ubiquitylation and deubiquitylation of PCNA occurs during S-phase to ensure processive DNA replication. PMID:27151298

  10. MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration

    PubMed Central

    Aranda, Juan F.; Reglero-Real, Natalia; Kremer, Leonor; Marcos-Ramiro, Beatriz; Ruiz-Sáenz, Ana; Calvo, María; Enrich, Carlos; Correas, Isabel; Millán, Jaime; Alonso, Miguel A.

    2011-01-01

    Membrane organization into condensed domains or rafts provides molecular platforms for selective recruitment of proteins. Cell migration is a general process that requires spatiotemporal targeting of Rac1 to membrane rafts. The protein machinery responsible for making rafts competent to recruit Rac1 remains elusive. Some members of the MAL family of proteins are involved in specialized processes dependent on this type of membrane. Because condensed membrane domains are a general feature of the plasma membrane of all mammalian cells, we hypothesized that MAL family members with ubiquitous expression and plasma membrane distribution could be involved in the organization of membranes for cell migration. We show that myeloid-associated differentiation marker (MYADM), a protein with unique features within the MAL family, colocalizes with Rac1 in membrane protrusions at the cell surface and distributes in condensed membranes. MYADM knockdown (KD) cells had altered membrane condensation and showed deficient incorporation of Rac1 to membrane raft fractions and, similar to Rac1 KD cells, exhibited reduced cell spreading and migration. Results of rescue-of-function experiments by expression of MYADM or active Rac1L61 in cells knocked down for Rac1 or MYADM, respectively, are consistent with the idea that MYADM and Rac1 act on parallel pathways that lead to similar functional outcomes. PMID:21325632

  11. Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA.

    PubMed

    Álvarez, Vanesa; Viñas, Laura; Gallego-Sánchez, Alfonso; Andrés, Sonia; Sacristán, María P; Bueno, Avelino

    2016-05-06

    Proliferating-cell nuclear antigen (PCNA) is a DNA sliding clamp with an essential function in DNA replication and a key role in tolerance to DNA damage by ensuring the bypass of lesions. In eukaryotes, DNA damage tolerance is regulated by ubiquitylation of lysine 164 of PCNA through a well-known control mechanism; however, the regulation of PCNA deubiquitylation remains poorly understood. Our work is a systematic and functional study on PCNA deubiquitylating enzymes (DUBs) in Schizosaccharomyces pombe. Our study reveals that the deubiquitylation of PCNA in fission yeast cells is a complex process that requires several ubiquitin proteases dedicated to the deubiquitylation of a specific subnuclear fraction of mono- and di-ubiquitylated PCNA or a particular type of poly-ubiquitylated PCNA and that there is little redundancy among these enzymes. To understand how DUB activity regulates the oscillatory pattern of ubiquitylated PCNA in fission yeast, we assembled multiple DUB mutants and found that a quadruple mutation of ubp2(+), ubp12(+), ubp15(+), and ubp16(+) leads to the stable accumulation of mono-, di-, and poly-ubiquitylated forms of PCNA, increases S-phase duration, and sensitizes cells to DNA damage. Our data suggest that the dynamic ubiquitylation and deubiquitylation of PCNA occurs during S-phase to ensure processive DNA replication.

  12. Natural phenomena hazards assessment criteria for DOE sites: DOE Standard DOE-STD-1023-95

    SciTech Connect

    Chen, J.C.; Lu, S.C.; Boissonnade, A.C.

    1995-03-24

    This paper summarizes hazard assessment criteria (DOE-STD-1023-95) for Natural Phenomena Hazards (NPH) at DOE sites. The DOE has established policy and requirements for NPH mitigation for DOE sites and facilities using a graded approach by DOE Order 5480.28. The graded approach is implemented by five performance categories established for structures, systems, and components (SSCs) at DOE facilities based on criteria provided by DOE-STD-1021-93. In applying the design/evaluation criteria of DOE-STD-1020-94 for DOE facilities subjected to one of the natural phenomena hazards, the establishment of design basis load levels consistent with the corresponding performance category is required. This standard provides general criteria as well as specific criteria for natural phenomena hazard assessments to ensure that adequate design basis load levels are established for design and/or evaluation of DOE facilities.

  13. Administration of rectal indomethacin does not reduce the requirement for intravenous narcotic analgesia in acute renal colic.

    PubMed

    Ginifer, C; Kelly, A M

    1996-06-01

    The aim of this study was to compare the total dose of intravenous pethidine required to give satisfactory analgesia to patients with acute renal colic between two groups, one of which was also administered rectal indomethacin on presentation and one which was not. This was a prospective, randomized, unblinded comparison study. Each group contained 39 patients. Group 1 received rectal indomethacin 100 mg and intravenous pethidine in 25 mg increments until pain was satisfactorily relieved. Group 2 received increments of intravenous pethidine alone. The primary endpoint was total pethidine dose required to achieve analgesia to the patient's satisfaction. No significant difference in total pethidine dose between the groups was found. It was concluded that administration of rectal indomethacin does not reduce the total dose of intravenous pethidine required to relieve the pain of acute renal colic.

  14. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45 What... all donors of cells or tissue used in HCT/Ps, except as provided under § 1271.90. In the case of an embryo or of cells derived from an embryo, a donor-eligibility determination is required for both...

  15. 40 CFR 141.571 - What records does subpart T require my system to keep?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Disinfection-Systems Serving Fewer Than 10,000 People Reporting and Recordkeeping Requirements § 141.571 What....560-141.564) Results of individual filter monitoring At least 3 years. (b) Disinfection Profiling(§§ 141.530-141.536) Results of Profile (including raw data and analysis) Indefinitely. (c) Disinfection...

  16. Does the Naked Neck Meat Type Chicken Yield Lower Methionine Requirement Data?

    PubMed

    Khan, Daulat R; Wecke, Christian; Liebert, Frank

    2015-03-25

    Methionine (Met) requirement studies with homozygous (Na/Na) and heterozygous (Na/na) naked neck meat type chicken utilized 144 birds of average weight (50% each genotype and sex) within two N balance experiments involving both the starter (d10-20) and grower period (d25-35). The birds were randomly allotted to five experimental diets with graded protein supply and Met as the limiting amino acid. The proportion of native feed protein sources (soy protein concentrate, maize, wheat, fishmeal and wheat gluten) was kept constant to ensure a uniform protein quality in all diets. The Met requirement depending on genotype, sex, age period and growth performance (protein deposition) was estimated using a non-linear modeling procedure of N utilization in monogastric animals. On average, 0.47% (Na/Na) and 0.45% (Na/na) dietary Met was established as adequate in the starter diet, as well as 0.37% (Na/Na) and 0.36% (Na/na) Met in the grower diet for both of the sexes. In conclusion, the Met requirement of the naked neck chicken is not significantly different from its normally-feathered counterparts. In addition, the low feather production was not reflected by reduced requirement for Met in naked neck birds. However, these conclusions are valid only at the given Met:Cys ratio (1:1) in the experimental diets.

  17. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45 What... all donors of cells or tissue used in HCT/Ps, except as provided under § 1271.90. In the case of an embryo or of cells derived from an embryo, a donor-eligibility determination is required for both...

  18. 21 CFR 1271.45 - What requirements does this subpart contain?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED PRODUCTS Donor Eligibility § 1271.45 What... all donors of cells or tissue used in HCT/Ps, except as provided under § 1271.90. In the case of an embryo or of cells derived from an embryo, a donor-eligibility determination is required for both...

  19. Does cognition in the disconnected right hemisphere require right hemisphere possession of language?

    PubMed

    Bogen, J E

    1997-03-01

    It has been asserted at times that the human right hemisphere is cognitively inferior to that of a chimpanzee or even a monkey. Related is the even stronger claim that human consciousness, as well as cognition, requires language. These claims are discussed, and counterexamples are presented from both split-brain subjects and patients hemispherectomized in adulthood after customary development as righthanders.

  20. Visual Literacy: Does It Enhance Leadership Abilities Required for the Twenty-First Century?

    ERIC Educational Resources Information Center

    Bintz, Carol

    2016-01-01

    The twenty-first century hosts a well-established global economy, where leaders are required to have increasingly complex skills that include creativity, innovation, vision, relatability, critical thinking and well-honed communications methods. The experience gained by learning to be visually literate includes the ability to see, observe, analyze,…

  1. Visual Literacy: Does It Enhance Leadership Abilities Required for the Twenty-First Century?

    ERIC Educational Resources Information Center

    Bintz, Carol

    2016-01-01

    The twenty-first century hosts a well-established global economy, where leaders are required to have increasingly complex skills that include creativity, innovation, vision, relatability, critical thinking and well-honed communications methods. The experience gained by learning to be visually literate includes the ability to see, observe, analyze,…

  2. Does Teacher Testing Raise Teacher Quality? Evidence from State Certification Requirements

    ERIC Educational Resources Information Center

    Angrist, Joshua D.; Guryan, Jonathan

    2008-01-01

    The education reform movement includes efforts to raise teacher quality through stricter certification and licensing provisions. Most US states now require public school teachers to pass a standardized test such as the Praxis. Although any barrier to entry is likely to raise wages in the affected occupation, the theoretical effects of such…

  3. Low thrombogenicity of polyethylene glycol-grafted cellulose membranes does not influence heparin requirements in hemodialysis.

    PubMed

    Wright, M J; Woodrow, G; Umpleby, S; Hull, S; Brownjohn, A M; Turney, J H

    1999-07-01

    Heparin is the most commonly used anticoagulant for hemodialysis despite potentially serious side effects. Polyethylene glycol-grafted cellulose (PGC) membranes produce less activation of the coagulation cascade than cuprophane membranes. Anecdotally, we found some patients required a surprisingly low level of anticoagulation using these membranes. We compared the anticoagulant requirement of the PGC membrane with that of the cuprophane membrane in this randomized, prospective, crossover study. Sixty-three patients were randomized to treatment using either membrane, and heparin administration was progressively reduced to the lowest dose that prevented visible clotting in excess of that normally encountered. Patients underwent dialysis at this dose for 1 month, after which the heparin requirement and Kt/Vurea (1.162 x ln [urea pre/urea post]) were assessed. This process was then repeated for each patient using the other membrane, and the results were compared. Heparin administration during dialysis was reduced from a mean loading dose of 29.0 +/- 9.4 to 1.5 +/- 3.2 IU/kg for both membranes and a mean maintenance infusion of 14.0 +/- 6.7 to 0.77 +/- 1.6 IU/kg/h for both membranes (both P < 0.0001 v full anticoagulation; no difference between membranes). The Kt/Vurea was not significantly altered. Forty-six patients with PGC and 45 patients with cuprophane membranes underwent dialysis successfully without heparin during dialysis, and the other patients were using considerably reduced doses. Aspirin and warfarin had no effect on the heparin requirement. These results do not support the theory that PGC membranes have a lower anticoagulant requirement than cuprophane membranes; however, they suggest that dialysis can be performed successfully with much smaller anticoagulant doses than are currently in common use.

  4. Development of visual category selectivity in ventral visual cortex does not require visual experience

    PubMed Central

    van den Hurk, Job; Van Baelen, Marc; Op de Beeck, Hans P.

    2017-01-01

    To what extent does functional brain organization rely on sensory input? Here, we show that for the penultimate visual-processing region, ventral-temporal cortex (VTC), visual experience is not the origin of its fundamental organizational property, category selectivity. In the fMRI study reported here, we presented 14 congenitally blind participants with face-, body-, scene-, and object-related natural sounds and presented 20 healthy controls with both auditory and visual stimuli from these categories. Using macroanatomical alignment, response mapping, and surface-based multivoxel pattern analysis, we demonstrated that VTC in blind individuals shows robust discriminatory responses elicited by the four categories and that these patterns of activity in blind subjects could successfully predict the visual categories in sighted controls. These findings were confirmed in a subset of blind participants born without eyes and thus deprived from all light perception since conception. The sounds also could be decoded in primary visual and primary auditory cortex, but these regions did not sustain generalization across modalities. Surprisingly, although not as strong as visual responses, selectivity for auditory stimulation in visual cortex was stronger in blind individuals than in controls. The opposite was observed in primary auditory cortex. Overall, we demonstrated a striking similarity in the cortical response layout of VTC in blind individuals and sighted controls, demonstrating that the overall category-selective map in extrastriate cortex develops independently from visual experience. PMID:28507127

  5. In vitro RNA editing in plant mitochondria does not require added energy.

    PubMed

    Takenaka, Mizuki; Verbitskiy, Daniil; van der Merwe, Johannes A; Zehrmann, Anja; Plessmann, Uwe; Urlaub, Henning; Brennicke, Axel

    2007-06-12

    RNA editing in flowering plant mitochondria is investigated by in vitro assays. These cauliflower mitochondrial lysates require added NTP or dNTP. We have now resolved the reason for this requirement to be the inhibition of the RNA binding activity of the glutamate dehydrogenases (GDH). Both GDH1 and GDH2 were identified in RNA-protein cross-links. The inhibition of in vitro RNA editing by GDH is confirmed by the ability of the GDH-specific herbicide phosphinothricin to substitute for NTP. NADH and NADPH, but not NAD or NADP, can also replace NTP, suggesting that the NAD(P)H-binding-pocket configuration of the GDH contacts the RNA. RNA editing in plant mitochondria is thus intrinsically independent of added energy in the form of NTP.

  6. Does requiring continuing education units for professional licensing renewal assure quality patient care?

    PubMed

    Vaughn, H Todd; Rogers, Janet L; Freeman, Julie K

    2006-01-01

    Although most states in the United States require health care professionals to complete continuing education units (CEUs) for licensure renewal, little evidence to date has established a relationship between completing CEUs and clinical competency. Considering the high cost of health care delivery and services, it would be prudent for both managers and consumers of health care to review the costs and benefits of requiring CEUs for professional licensing renewal. This study features an extensive review of the literature to analyze the supportive as well as the opposing views of mandatory CEUs for professional license renewal. Most of the studies reviewed reported almost no relationship between participation in traditional continuing education courses and improved patient outcomes. Several recommendations evolved out of this study for improving patient outcomes following the attendance of continuing education courses.

  7. Increasing dietary crude protein does not increase the essential amino acid requirements of kittens.

    PubMed

    Strieker, M J; Morris, J G; Rogers, Q R

    2006-08-01

    Essential amino acid (EAA) requirements of omnivores and herbivores (e.g. chicks, lambs, pigs and rats) are directly related to the concentration of dietary crude protein (CP). When an EAA is limiting in the diet, addition of a mixture of EAA lacking the limiting one (which increases dietary CP) results in a decrease in food intake and weight gain. This interaction has been referred to as an AA imbalance and has not been studied in depth in strict carnivores. The objectives of these experiments were to examine the effects on growing kittens (2-week periods) of the addition to diets of a mixture of AA lacking the limiting one. The control diets were at the requirement of the respective limiting EAA (or about 85% of the 1986 National Research Council requirement). In experiment 1, with the dietary EAAs at the minimally determined requirements, the concentration of the essential or dispensable amino acids was increased to determine if CP or an EAA was limiting. Results of growth rates (n = 12) and plasma AA concentrations indicated that tryptophan was limiting, but increased body weight gain also occurred when the concentration of CP was increased as dispensable amino acids without additional tryptophan. Experiment 1 was repeated in experiment 2 using a crossover design. Again, when tryptophan was limiting additional concentrations of dispensable AAs increased body weight gain. This response is the opposite of that in herbivores and omnivores. Experiment 3 consisted of 10 separate crossover trials, one for each of the 10 EAA and examined the effect of two concentrations of dietary CP (200 and 300 g CP/kg diet) on body weight gain of kittens (n = 8) offered diets limiting in each respective EAA. Body weight gain was numerically greater when diets contained 300 g CP/kg than 200 g CP/kg for eight of 10 EAAs (p < 0.05 for only isoleucine and threonine) when each amino acid was limiting. This response is the reverse of that which occurs in chicks, lambs, pigs and rats when

  8. Progression of relapsing-remitting demyelinating disease does not require increased TCR affinity or epitope spread

    PubMed Central

    Kersh, Anna E.; Edwards, Lindsay J.; Evavold, Brian D.

    2014-01-01

    In this study, we investigate the basis of T cell recognition of myelin that governs the progression from acute symptoms into disease remission, relapse and chronic progression in a secondary progressive model of demyelinating disease. Until now, the frequency and affinity of myelin-reactive CD4 T cells that elicit relapsing-remitting disease have not been quantified. The micropipette adhesion frequency assay was used to obtain a sensitive and physiologically relevant two-dimensional measurement of frequency and TCR affinity for myelin, as the inherent low affinity does not allow the use of specific-peptide:MHC-II tetramers for this purpose. We found the highest affinity and frequency of polyclonal myelin oligodendrocyte glycoprotein (MOG)-reactive cells infiltrate the CNS during acute disease, while affinities during remission, relapse and chronic disease are not significantly different from each other. Frequency analysis revealed that the vast majority of CNS-infiltrating CD4 T cells are MOG-reactive at all time points demonstrating epitope spread is not a predominant factor for disease progression. Further, time points at which mice were symptomatic were characterized by an infiltration of Th17 cells in the CNS while symptom remission showed an enrichment of cells producing IFN-γ. Also, the ratio of regulatory T cells to Foxp3- CD4 T cells was significantly higher in the CNS at remission than during acute disease. The results of this study indicate that a high frequency of T cells specific for a single myelin antigen, rather than increased TCR affinity or epitope spread, govern the transition from acute symptoms through remission, relapse and chronic disease states. PMID:25267971

  9. Increasing dietary crude protein does not increase the methionine requirement in kittens.

    PubMed

    Strieker, M J; Morris, J G; Kass, P H; Rogers, Q R

    2007-12-01

    The objective of this study was to determine if the methionine (met) requirement of kittens is correlated with the concentration of dietary crude protein (CP). The study used 48 male kittens in two replications of six 4 x 4 Latin squares, each representing one concentration of met (1.5, 2.5, 3.5, 4.5, 6.0 or 9.0 g/kg diet) with four CP concentrations (150, 200, 300 and 500 g/kg diet) in 2-week periods. Cystine was present in the lowest CP diet at 5.3 g/kg diet and increased as dietary CP increased. Body weight gain, food intake, nitrogen balance and plasma amino acids, glucose, insulin, cortisol, somatomedin C, T(3) and T(4) concentrations on day 12 were measured. From breakpoint analysis of the nitrogen retention curves, the met requirement of kittens was found to be 3.1, 3.8, 3.1 and 2.4 g met/kg for the 150, 200, 300 and 500 g CP/kg diets, respectively. When met was limiting (1.5 or 2.5 g/kg diet), increasing dietary CP did not decrease, but rather increased food intake, body weight gain and nitrogen retention. Plasma met concentrations increased as dietary met increased and at 2.5-3.5 g met/kg diet were not different among kittens fed the various CP diets. Total plasma T(3) and T(4) increased significantly as dietary CP increased in kittens given the 2.5 and 4.5 g met/kg diets. Results indicate that food intake and possibly altered hormonal secretion play a role in this growth response. In conclusion, the met requirement of growing kittens, unlike omnivores and herbivores studied, was not positively correlated with the concentration of dietary CP.

  10. Does Slow Slip and Tremor Require High Fluid Pressure? Thoughts From Observations in Retrograde Faults

    NASA Astrophysics Data System (ADS)

    Fagereng, A.; Diener, J. F. A.; Stenvall, C.

    2016-12-01

    Subduction zone tremor and slow slip appear spatially correlated with elevated pore fluid pressures related to prograde dehydration reactions in water-saturated subducting rocks. However, tremor and slow slip have also been observed in other tectonic settings, notably on the San Andreas and Alpine faults, where displacement of previously dehydrated rocks occurs along trajectories of decreasing temperature and pressure. Here, fluids are not produced by local dehydration reactions, and external fluids introduced to the fault may be consumed by retrograde hydration reactions. Thus, we suggest that tremor and slow slip in retrograde shear zones imply weakening and strain localization without high fluid pressures, and test this hypothesis against observations in an exhumed, retrograde, continental shear zone. The Kuckaus Mylonite Zone (KMZ), Namibia, accommodated crustal scale strike-slip displacement of granitoid gneisses and migmatites at 450 - 480°C and 270 - 420 MPa, conditions representative of the continuation of continental fault zones below the base of the crustal seismogenic zone. High strain zones within the KMZ comprise fine grained retrograde mineral assemblages requiring rehydration of the original high temperature mineral assemblages in the host rock. Lack of local fluid sources implies that rehydration required influx of an external fluid. We see only minor evidence for hydrothermal vein formation related to this fluid, but note metasomatic alteration and local evidence for dissolution-precipitation. We propose that the main contribution of the fault zone fluid was to allow growth of retrograde, weak, mineral phases, and facilitate grain size reduction through nucleation of new grains, activating grain-size sensitive creep at low driving stresses. Tremor and slow slip observed on active faults under similar conditions may also not require high fluid pressures, but rather be explained by reaction weakening under hydrostatic fluid pressure conditions.

  11. Does protein relatedness require sequence matching? Alignment via networks in sequence space.

    PubMed

    Frenkel, Zakharia M

    2008-10-01

    To establish possible function of a newly discovered protein, alignment of its sequence with other known sequences is required. When the similarity is marginal, the function remains uncertain. A principally new approach is suggested: to use networks in the protein sequence space. The functionality of the protein is firmly established via networks forming chains of consecutive pair-wise matching fragments. The distant relatives are, thus, considered as relatives, though in some cases, there is even no sequence match between the ends of the chain, while the entire chain belongs to the same functional and structural network.

  12. 1995 Annual report on waste generation and waste mainization progress as required by DOE order 5400.1, Hanford site

    SciTech Connect

    Betsch, M.D.

    1996-09-24

    While waste generation numbers are important, the true measure of success is waste minimized. Many Waste Minimization/Pollution Prevention (WMin/P2) successes at the Hanford Site occur every day without formal recognition as pollution prevention, as they have become part of a culture of best management practices. As an example, the success of the excess and reuse program, both informal and formal, documents the Wmin/P2 culture that exists in the pollution prevention representatives and employees at the facilities.

  13. 1999 Annual Report on Waste Generation and Pollution Prevention Progress as Required by DOE Order 5400.1

    SciTech Connect

    SEGALL, P.

    2000-03-01

    Hanford's missions are to safely clean-up and manage the site's legacy wastes, and to develop and deploy science and technology. Through these missions Hanford will contribute to economic diversification of the region. Hanford's environmental management or clean-up mission is to protect the health and safety of the public, workers, and the environment; control hazardous materials; and utilize the assets (people, infrastructure, and site) for other missions. Hanford's science and technology mission is to develop and deploy science and technology in the service of the nation including stewardship of the Hanford Site. Pollution Prevention is a key to the success of these missions by reducing the amount of waste to be managed and identifying/implementing cost effective waste reduction projects. Hanford's original mission, the production of nuclear materials for the nation's defense programs, lasted more than 40 years, and like most manufacturing operations, Hanford's operations generated large quantities of waste and pollution. However, the by-products from Hanford operations pose unique problems like radiation hazards, vast volumes of contaminated water and soil, and many contaminated structures including reactors, chemical plants and evaporation ponds. The clean-up activity is an immense and challenging undertaking. Including characterization and decommissioning of 149 single shell storage tanks, treating 28 double shell tanks, safely disposing of over 2,100 metric tons of spent nuclear fuel stored on site, removing numerous structures, and dealing with significant solid waste, ground water, and land restoration issues.

  14. 1994 Annual report on waste generation and waste minimization progress as required by DOE Order 5400.1, Hanford Site

    SciTech Connect

    1995-09-01

    Many Waste Minimization/Pollution Prevention successes at the Hanford Site occur every day without formal recognition. A few of the successful projects are: T-Plant helps facilities reuse equipment by offering decontamination services for items such as gas cylinders, trucks, and railcars, thus saving disposal and equipment replacement costs. Custodial Services reviewed its use of 168 hazardous cleaning products, and, through a variety of measures, replaced them with 38 safer substitutes, one for each task. Scrap steel contaminated with low level radioactivity from the interim stabilization of 107-K and 107-C was decontaminated and sold to a vendor for recycling. Site-wide programs include the following: the Pollution Prevention Opportunity Assessment (P2OA) program at the Hanford site was launched during 1994, including a training class, a guidance document, technical assistance, and goals; control over hazardous materials purchased was achieved by reviewing all purchase requisitions of a chemical nature; the Office Supply Reuse Program was established to redeploy unused or unwanted office supply items. In 1994, pollution prevention activities reduced approximately 274,000 kilograms of hazardous waste, 2,100 cubic meters of radioactive and mixed waste, 14,500,000 kilograms of sanitary waste, and 215,000 cubic meters off liquid waste and waste water. Pollution Prevention activities also saved almost $4.2 million in disposal, product, and labor costs. Overall waste generation increased in 1994 due to increased work and activity typical for a site with an environmental restoration mission. However, without any Waste Minimization/Pollution Prevention activities, solid radioactive waste generation at Hanford would have been 25% higher, solid hazardous waste generation would have been 30% higher, and solid sanitary waste generation would have been 60% higher.

  15. 1997 annual report on waste generation and waste minimization progress as required by DOE Order 5400.1, Hanford Site

    SciTech Connect

    Segall, P.

    1998-04-13

    Hanford`s missions are to safely clean up and manage the site`s legacy wastes, and to develop and deploy science and technology. Through these missions Hanford will contribute to economic diversification of the region. Hanford`s environmental management or cleanup mission is to protect the health and safety of the public, workers, and the environment; control hazardous materials; and utilize the assets (people, infra structure, site) for other missions. Hanford`s science and technology mission is to develop and deploy science and technology in the service of the nation including stewardship of the Hanford Site. Pollution Prevention is a key to the success of these missions by reducing the amount of waste to be managed and identifying/implementing cost effective waste reduction projects. Hanford`s original mission, the production of nuclear materials for the nation`s defense programs, lasted more than 40 years, and like most manufacturing operations, Hanford`s operations generated large quantities of waste and pollution. However, the by-products from Hanford operations pose unique problems like radiation hazards, vast volumes of contaminated water and soil, and many contaminated structures including reactors, chemical plants and evaporation ponds. The cleanup activity is an immense and challenging undertaking, which includes characterization and decommissioning of 149 single shell storage tanks, treating 28 double shell tanks, safely disposing of over 2,100 metric tons of spent nuclear fuel stored on site, removing numerous structures, and dealing with significant solid waste, ground water, and land restoration issues.

  16. Resident Physician Duty-hour Requirements: What Does the Public Think?

    PubMed

    Mercuri, John J; Okey, Neil E; Karia, Raj J; Gross, Richard H; Zuckerman, Joseph D

    2016-11-01

    To date, no study has reported on the public's opinion of orthopaedic resident duty-hour requirements (DHR). A survey was administered to people in orthopaedic waiting rooms and at three senior centers. Responses were analyzed to evaluate seven domains: knowledge of duty hours; opinions about duty hours; attitudes regarding shift work; patient safety concerns; and the effects of DHRs on continuity of care, on resident training, and on resident professionalism. Respondents felt that fatigue was unsafe and duty hours were beneficial in preventing resident physician fatigue. They supported the idea of residents working in shifts but did not support shifts for attending physicians. However, respondents wanted the same resident to provide continuity of care, even if that violated DHRs. They were supportive of increasing the length of residency to complete training. DHRs were not believed to affect professionalism. Half of the respondents believed that patient opinion should influence policy on this topic. Orthopaedic patients and those likely to require orthopaedic care have inconsistent opinions regarding DHRs, making it potentially difficult to incorporate their preferences into policy.

  17. Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site.

    PubMed Central

    Aroian, R V; Levy, A D; Koga, M; Ohshima, Y; Kramer, J M; Sternberg, P W

    1993-01-01

    The dinucleotide AG, found at the 3' end of virtually all eukaryotic pre-mRNA introns, is thought to be essential for splicing. Reduction-of-function mutations in two Caenorhabditis elegans genes, the receptor tyrosine kinase gene let-23 and the collagen gene dpy-10, both alter the AG at the end of a short (ca. 50-nucleotide) intron to AA. The in vivo effects of these mutations were studied by sequencing polymerase chain reaction-amplified reverse-transcribed RNA isolated from the two mutants. As expected, we find transcripts that splice to a cryptic AG, skip an exon, and retain an unspliced intron. However, we also find significant levels of splicing at the mutated 3' splice site (AA) and at nearby non-AG dinucleotides. Our results indicate that for short C. elegans introns an AG is not required for splicing at either the correct 3' splice site or incorrect sites. Analysis of a splice site mutant involving a longer, 316-nucleotide C. elegans intron indicates that an AG is also not required there for splicing. We hypothesize that elements besides the invariant AG, e.g., an A-U-rich region, a UUUC motif, and/or a potential branch point sequence, are directing the selection of the 3' splice site and that in wild-type genes these elements cooperate so that proper splicing occurs. Images PMID:8417357

  18. Regulated membrane protein entry into flagella is facilitated by cytoplasmic microtubules and does not require IFT.

    PubMed

    Belzile, Olivier; Hernandez-Lara, Carmen I; Wang, Qian; Snell, William J

    2013-08-05

    The membrane protein composition of the primary cilium, a key sensory organelle, is dynamically regulated during cilium-generated signaling [1, 2]. During ciliogenesis, ciliary membrane proteins, along with structural and signaling proteins, are carried through the multicomponent, intensely studied ciliary diffusion barrier at the base of the organelle [3-8] by intraflagellar transport (IFT) [9-18]. A favored model is that signaling-triggered accumulation of previously excluded membrane proteins in fully formed cilia [19-21] also requires IFT, but direct evidence is lacking. Here, in studies of regulated entry of a membrane protein into the flagellum of Chlamydomonas, we show that cells use an IFT-independent mechanism to breach the diffusion barrier at the flagellar base. In resting cells, a flagellar signaling component [22], the integral membrane polypeptide SAG1-C65, is uniformly distributed over the plasma membrane and excluded from the flagellar membrane. Flagellar adhesion-induced signaling triggers rapid, striking redistribution of the protein to the apical ends of the cells concomitantly with entry into the flagella. Protein polarization and flagellar enrichment are facilitated by cytoplasmic microtubules. Using a conditional anterograde IFT mutant, we demonstrate that the IFT machinery is not required for regulated SAG1-C65 entry into flagella. Thus, integral membrane proteins can negotiate passage through the ciliary diffusion barrier without the need for a motor.

  19. ePro-ClearSee: a simple immunohistochemical method that does not require sectioning of plant samples

    PubMed Central

    Nagaki, Kiyotaka; Yamaji, Naoki; Murata, Minoru

    2017-01-01

    Investigations into the epigenetic status of individual cells within tissues can produce both epigenetic data for different cell types and positional information of the cells. Thus, these investigations are important for understanding the intra- and inter-cellular control systems of developmental and environmental responses in plants. However, a simple method to detect epigenetic modifications of individual cells in plant tissues is not yet available because detection of the modifications requires immunohistochemistry using specific antibodies. In this study, we developed a simple immunohistochemical method that does not require sectioning to investigate epigenetic modifications. This method uses a clearing system to detect methylated histones, acetylated histones, methylated DNA and/or centromeric histone H3 variants. Analyses of four dicots and five monocots indicated that this method provides a universal technique to investigate epigenetic modifications in diverse plant species. PMID:28176832

  20. Influence of rabbit sire genetic origin, season of birth and parity order on doe and litter performance in an organic production system.

    PubMed

    Zotte, Antonella Dalle; Paci, Gisella

    2013-01-01

    The aim of this study was to compare both the performance of litters derived from two sire genetic origins (SGO), Vienna Blue (VB) and Burgundy Fawn (BF), along successive seasons of birth (SB; winter, spring, summer and autumn), and doe reproductive performance in an organic production system. A total of fifty-eight does consisting of a mixture of crosses of several medium-large size breeds at different parity order (P, 1 = nulliparous; 2 = primiparous; ≥3 = multiparous) and twelve males (6 VB and 6 BF) were housed indoors at environmental conditions that followed seasonality. An extensive reproductive rhythm was used and kits were weaned at 46±6 d of age. Doe reproductive performance and the data of 105 litters (55 from VB and 50 from BF SGO) were recorded throughout the SB. No statistically significant differences related to SGO effect were observed. As regards parity order, multiparous does showed higher live weights (LW) (p<0.05), total born (p<0.01), total born alive (p<0.05) per delivery, and litter weight of born alive (p<0.05), but lower milk output at 21st d than primiparous does (p<0.05). The extensive reproductive rhythm mainly increased litter performance at birth in multiparous does but was not sufficient to permit a complete recovery of body reserves lost during lactation. Autumn SB negatively affected doe LW variation between deliveries. The number of pups born and born alive per delivery (p<0.05) and litter size at 21 d of age and at weaning (p<0.01) were lower during hot SB. Due to the lower litter size of pups born in summer and autumn, their individual weight at 21st d of age and daily individual growth rate 0 to 21 d were higher than those of pups born in winter (p<0.001). Litter performance at 21st d of age and individual pup pre-weaning growth rate were poorer for those born in spring than in other seasons due to the harmful effects of increased environmental temperatures. SB affected most of the performance traits of does and young

  1. Does It Help to Use Mathematically Superfluous Brackets When Teaching the Rules for the Order of Operations?

    ERIC Educational Resources Information Center

    Gunnarsson, Robert; Sönnerhed, Wang Wei; Hernell, Bernt

    2016-01-01

    The hypothesis that mathematically superfluous brackets can be useful when teaching the rules for the order of operations is challenged. The idea of the hypothesis is that with brackets it is possible to emphasize the order priority of one operation over another. An experiment was conducted where expressions with mixed operations were studied,…

  2. Does It Help to Use Mathematically Superfluous Brackets When Teaching the Rules for the Order of Operations?

    ERIC Educational Resources Information Center

    Gunnarsson, Robert; Sönnerhed, Wang Wei; Hernell, Bernt

    2016-01-01

    The hypothesis that mathematically superfluous brackets can be useful when teaching the rules for the order of operations is challenged. The idea of the hypothesis is that with brackets it is possible to emphasize the order priority of one operation over another. An experiment was conducted where expressions with mixed operations were studied,…

  3. Preparation, review, and approval of implementation plans for nuclear safety requirements

    SciTech Connect

    Not Available

    1994-10-01

    This standard describes an acceptable method to prepare, review, and approve implementation plans for DOE Nuclear Safety requirements. DOE requirements are identified in DOE Rules, Orders, Notices, Immediate Action Directives, and Manuals.

  4. Ego depletion and positive illusions: does the construction of positivity require regulatory resources?

    PubMed

    Fischer, Peter; Greitemeyer, Tobias; Frey, Dieter

    2007-09-01

    Individuals frequently exhibit positive illusions about their own abilities, their possibilities to control their environment, and future expectations. The authors propose that positive illusions require resources of self-control, which is considered to be a limited resource similar to energy or strength. Five studies revealed that people with depleted self-regulatory resources indeed exhibited a less-optimistic sense of their own abilities (Study 1), a lower sense of subjective control (Study 2), and less-optimistic expectations about their future (Study 3). Two further studies shed light on the underlying psychological process: Ego-depleted (compared to nondepleted) individuals generated/retrieved less positive self-relevant attributes (Studies 4 and 5) and reported a lower sense of general self-efficacy (Study 5), which both partially mediated the impact of ego depletion on positive self-views (Study 5).

  5. Does the Incremental Shuttle Walking Test require maximal effort in healthy subjects of different ages?

    PubMed

    Gonçalves, Cristiane Golias; Mesquita, Rafael; Hayashi, Daniela; Merli, Myriam Fernanda; Vidotto, Laís Silva; Fernandes, Karen Barros Parron; Probst, Vanessa S

    2015-06-01

    To evaluate if the Incremental Shuttle Walking Test (ISWT) requires maximal effort in healthy subjects of different ages. Cross-sectional. University-based research laboratory. 331 healthy subjects separated into six groups according to age: G1, 18 to 28 years; G2, 29 to 39 years; G3, 40 to 50 years; G4, 51 to 61 years; G5, 62 to 72 years and; G6, 73 to 83 years. Two ISWTs were performed and participants were permitted to run and to exceed 12 levels during the test, if necessary. Heart rate (HR) and symptoms of dyspnoea and fatigue were recorded before and after the test, and the percentage of age-predicted maximal HR (HRmax) was calculated. Maximal effort was defined as HRmax >90% of age-predicted HRmax. Almost 31% of the subjects exceeded 12 levels in the ISWT. At the end of the test, all groups presented a median [interquartile range] HR greater than 90% of HRmax (G1: 100 [95 to 104]; G2: 100 [96 to 105]; G3: 103 [97 to 108]; G4: 99 [91 to 106]; G5: 96 [87 to 106] and G6: 96 [91 to 109]% HRmax). Regarding symptoms, all groups showed higher values after the test (P<0.05). A multiple logistic regression analysis identified female gender, older age and a lower HR before the test as determinants of not achieving 90% of HRmax at the end of the test. The ISWT requires maximal effort in healthy individuals, but for that it is necessary to extend the test beyond twelve levels. Female gender, older age and lower heart rate before the test are the determinants of not reaching maximal effort. Copyright © 2014 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

  6. Preoperative haemostasis testing does not predict requirement of blood products in cardiac surgery.

    PubMed

    Prohaska, W; Zittermann, A; Inoue, K; Tenderich, G; Lüth, J-U; Köster-Eiserfunke, W; Körfer, R; Kleesiek, K

    2008-11-24

    Standard haemostasis screening tests are performed to reveal unknown congenital or acquired disturbances of plasma and/or platelet haemostasis. Since their diagnostic efficacy is often low, routinely performed haemostasis testing has been questioned. We investigated whether preoperatively assessed haemostasis testing can be used to predict the requirement of blood products. We retrospectively assessed haemostasis parameters including platelet function testing by PFA 100 as well as the numbers of red blood cell (RBC) concentrates, fresh frozen plasmas (FFPs), and platelet concentrates (PCs) that were given peri-operatively and during the first two postoperative days in 2,831 cardiac surgery patients. Logistic regression analyses were used to select those parameters, which could predict blood product requirement. Of our study cohort, 56.5% needed RBCs, 15% FFPs, and 5% PCs. The need for RBCs was associated with significantly altered pre-operative values of most haemostasis parameters. However, by the use of logistic regression analysis fibrinogen was the only haemostasis parameter that was independently associated with the use of RBCs (odds ratio 1.56; 95% CI: 1.27-1.91; P <0.001). The predictive value of other parameters such as age, body weight, haemoglobin, and haematocrit was however much higher in comparison to fibrinogen (odds ratios: 1.92-3.50; P <0.001). It was not possible to develop a score based on haemostasis parameters to accurately identify patients at risk for RBC use. Moreover, we were unable to estimate the need for FFPs and PCs using preoperative haemostasis testing. Our data demonstrate that preoperatively performed haemostasis testing is not predictive in estimating the need for blood products in cardiac surgery patients.

  7. 25 CFR 1000.130 - Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or element of a program to be included in a non-BIA AFA? 1000.130... or element of a program to be included in a non-BIA AFA? No, the Act favors the inclusion of a...

  8. 25 CFR 1000.130 - Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or element of a program to be included in a non-BIA AFA? 1000.130... or element of a program to be included in a non-BIA AFA? No, the Act favors the inclusion of a...

  9. 25 CFR 1000.130 - Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or element of a program to be included in a non-BIA AFA? 1000.130... or element of a program to be included in a non-BIA AFA? No, the Act favors the inclusion of a...

  10. 25 CFR 1000.130 - Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or element of a program to be included in a non-BIA AFA? 1000.130... or element of a program to be included in a non-BIA AFA? No, the Act favors the inclusion of a...

  11. 25 CFR 1000.130 - Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Does a Tribe/Consortium need to be identified in an authorizing statute in order for a program or element of a program to be included in a non-BIA AFA? 1000.130... or element of a program to be included in a non-BIA AFA? No, the Act favors the inclusion of a...

  12. Hemodynamic Improvement in Cardiac Resynchronization Does Not Require Improvement in Left Ventricular Rotation Mechanics

    PubMed Central

    Ashikaga, Hiroshi; Leclercq, Christophe; Wang, Jiangxia; Kass, David A.; McVeigh, Elliot R.

    2010-01-01

    Background Earlier studies have yielded conflicting evidence on whether or not cardiac resynchronization therapy (CRT) improves left ventricular (LV) rotation mechanics. Methods and Results In dogs with left bundle branch block and pacing-induced heart failure (n=7), we studied the effects of CRT on LV rotation mechanics in vivo by 3-dimensional tagged magnetic resonance imaging with a temporal resolution of 14 ms. CRT significantly improved hemodynamic parameters but did not significantly change the LV rotation or rotation rate. LV torsion, defined as LV rotation of each slice with respect to that of the most basal slice, was not significantly changed by CRT. CRT did not significantly change the LV torsion rate. There was no significant circumferential regional heterogeneity (anterior, lateral, inferior, and septal) in LV rotation mechanics in either left bundle branch block with pacing-induced heart failure or CRT, but there was significant apex-to-base regional heterogeneity. Conclusions CRT acutely improves hemodynamic parameters without improving LV rotation mechanics. There is no significant circumferential regional heterogeneity of LV rotation mechanics in the mechanically dyssynchronous heart. These results suggest that LV rotation mechanics is an index of global LV function, which requires coordination of all regions of the left ventricle, and improvement in LV rotation mechanics appears to be a specific but insensitive index of acute hemodynamic response to CRT. PMID:20478988

  13. Does age affect analgesia provision at discharge among children with long bone fractures requiring emergency care?

    PubMed

    Ortega, Henry W; Vander Velden, Heidi; Lin, Chia-Wei; Engels, James A; Reid, Samuel

    2013-11-01

    Inadequate treatment of painful conditions in children is a significant and complex problem. The wide range of cognitive abilities associated with a child's age is a particular challenge for providers treating children with painful conditions. To examine the effect of patient age on the provision of analgesic medicines at discharge in children treated emergently for a long bone fracture. A retrospective review was performed of all patients during a 1-year period with a long bone fracture treated in two urban pediatric Emergency Departments (EDs). Eight hundred seventy-eight patients were identified who met our inclusion criteria. Nearly 60% of patients received a prescription for an opioid-containing medicine and 19% received a prescription for an over-the-counter analgesic medicine at ED discharge. Patients younger than 4 years old had lower pain scores, less severe fractures, and overall were significantly less likely to receive an opioid-containing prescription compared to children 4 years old or greater. In children with more severe fractures requiring reduction in the ED, no significant age-related differences were noted in opioid prescription rates. No age-related significant differences were noted for over-the-counter prescription analgesic medicines provided at discharge. Young patient age is associated with different analgesic prescription patterns in children treated in the ED for a long bone fracture. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Commentary: When does understanding phenotypic evolution require identification of the underlying genes?

    PubMed

    Rausher, Mark D; Delph, Lynda F

    2015-07-01

    Adaptive evolution is fundamentally a genetic process. Over the past three decades, characterizing the genes underlying adaptive phenotypic change has revealed many important aspects of evolutionary change. At the same time, natural selection is often fundamentally an ecological process that can often be studied without identifying the genes underlying the variation on which it acts. This duality has given rise to disagreement about whether, and under what circumstances, it is necessary to identify specific genes associated with phenotypic change. This issue is of practical concern, especially for researchers who study nonmodel organisms, because of the often enormous cost and labor required to "go for the genes." We here consider a number of situations and questions commonly addressed by researchers. Our conclusion is that although gene identification can be crucial for answering some questions, there are others for which definitive answers can be obtained without finding underlying genes. It should thus not be assumed that considerations of "empirical completeness" dictate that gene identification is always desirable. © 2015 The Author(s). Evolution © 2015 The Society for the Study of Evolution.

  15. Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression

    PubMed Central

    Naseem, Shamoon; Araya, Esteban; Konopka, James B.

    2015-01-01

    Various stimuli, including N-acetylglucosamine (GlcNAc), induce the fungal pathogen Candida albicans to switch from budding to hyphal growth. Previous studies suggested that hyphal morphogenesis is stimulated by transcriptional induction of a set of genes that includes known virulence factors. To better understand hyphal development, we examined the role of GlcNAc metabolism using a triple mutant lacking the genes required to metabolize exogenous GlcNAc (hxk1Δ nag1Δ dac1Δ). Surprisingly, at low ambient pH (∼pH 4), GlcNAc stimulated this mutant to form hyphae without obvious induction of hyphal genes. This indicates that GlcNAc can stimulate a separate signal to induce hyphae that is independent of transcriptional responses. Of interest, GlcNAc could induce the triple mutant to express hyphal genes when the medium was buffered to a higher pH (>pH 5), which normally occurs after GlcNAc catabolism. Catabolism of GlcNAc raises the ambient pH rather than acidifying it, as occurs after dextrose catabolism. This synergy between alkalinization and GlcNAc to induce hyphal genes involves the Rim101 pH-sensing pathway; GlcNAc induced rim101Δ and dfg16Δ mutants to form hyphae, but hyphal gene expression was partially defective. These results demonstrate that hyphal morphogenesis and gene expression can be regulated independently, which likely contributes to pathogenesis at different host sites. PMID:25609092

  16. Organ regeneration does not require a functional stem cell niche in plants.

    PubMed

    Sena, Giovanni; Wang, Xiaoning; Liu, Hsiao-Yun; Hofhuis, Hugo; Birnbaum, Kenneth D

    2009-02-26

    Plants rely on the maintenance of stem cell niches at their apices for the continuous growth of roots and shoots. However, although the developmental plasticity of plant cells has been demonstrated, it is not known whether the stem cell niche is required for organogenesis. Here we explore the capacity of a broad range of differentiating cells to regenerate an organ without the activity of a stem cell niche. Using a root-tip regeneration system in Arabidopsis thaliana to track the molecular and functional recovery of cell fates, we show that re-specification of lost cell identities begins within hours of excision and that the function of specialized cells is restored within one day. Critically, regeneration proceeds in plants with mutations that fail to maintain the stem cell niche. These results show that stem-cell-like properties that mediate complete organ regeneration are dispersed in plant meristems and are not restricted to niches, which nonetheless seem to be necessary for indeterminate growth. This regenerative reprogramming of an entire organ without transition to a stereotypical stem cell environment has intriguing parallels to recent reports of induced transdifferentiation of specific cell types in the adult organs of animals.

  17. Does the Discussion of Socio-Scientific Issues require a Paradigm Shift in Science Teachers' Thinking?

    NASA Astrophysics Data System (ADS)

    Day, Stephen P.; Bryce, Tom G. K.

    2011-08-01

    The purpose of this study was to characterise secondary school science teachers' conceptual models of discussion, against the background that a number of researchers have found that discussion of socio-scientific issues in science classrooms is rare, somewhat discomforting for teachers and its purpose unclear. Recent research indicates that when science teachers do engage in socio-scientific discussion, the quality is poor and is teacher-centred where pupils' views do not figure prominently (far less be clarified and integrated with their scientific learning). This has led to calls for such dialogue to be conducted by humanities teachers. The question arising from such thinking is: Do science teachers hold different conceptual models of discussion from their humanities colleagues? Using semi-structured interviews, three groups each of six teachers (experienced science teachers, experienced humanities teachers, and newly qualified science teachers) were interviewed in-depth in order to characterise their conceptual understanding of discussion as a teaching strategy. Analysis of the interview transcripts utilised the constant comparison approach of grounded theory. Five conceptual models of discussion emerged from an analysis of the data-discussion: (1) as a teacher-mediated discourse; (2) as open-ended inquiry; (3) for the development of reasoning skills; (4) as mediated transfer of knowledge to real-life contexts; and (5) as practice for democratic citizenship. The results confirmed that the science teachers' emphasis tended to stress practice for democratic citizenship whereas the humanities teachers' emphasis was more towards open-ended inquiry and for the development of reasoning skills.

  18. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family Violence...

  19. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family Violence...

  20. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  1. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  2. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  3. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  4. 42 CFR 83.10 - If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... under § 83.9, does this mean the class will be added to the Cohort? 83.10 Section 83.10 Public Health... for Adding Classes of Employees to the Cohort § 83.10 If a petition satisfies all relevant requirements under § 83.9, does this mean the class will be added to the Cohort? Satisfying the...

  5. 20 CFR 411.375 - Does a State VR agency continue to provide services under the requirements of the State plan...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Does a State VR agency continue to provide... Rehabilitation Agencies' Participation Participation in the Ticket to Work Program § 411.375 Does a State VR.... The State VR agency must continue to provide services under the requirements of the State plan...

  6. 12 CFR 1202.6 - What if my request does not have all the information FHFA or FHFA-OIG requires?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false What if my request does not have all the information FHFA or FHFA-OIG requires? 1202.6 Section 1202.6 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS FREEDOM OF INFORMATION ACT § 1202.6 What if my request does not have all...

  7. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family Violence...

  8. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family Violence...

  9. 42 CFR 136.404 - What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What does the Indian Child Protection and Family Violence Prevention Act require of the IHS and Indian Tribes or Tribal organizations receiving funds under... Protection and Family Violence Prevention § 136.404 What does the Indian Child Protection and Family Violence...

  10. Transendothelial migration of effector T cells across inflamed endothelial barriers does not require heparan sulfate proteoglycans.

    PubMed

    Stoler-Barak, Liat; Barzilai, Sagi; Zauberman, Ayelet; Alon, Ronen

    2014-06-01

    Leukocyte diapedesis is a chemotactic multistep process that requires optimal chemoattractant presentation by the endothelial barrier. Recent studies have described a critical role for heparan sulfate glycosaminoglycans (HSGAGs) in the presentation and functions of chemokines essential for lymphocyte interactions with the lymph node vasculature. We wished to test whether HS expression by a prototypic endothelial cell type, i.e. human umbilical vein endothelial cells (HUVECs), is critical for their ability to support neutrophil and lymphocyte adhesion and transendothelial migration (TEM) under shear flow. We found that HUVECs deposit HS GAGs mainly at their basolateral compartments in both their resting and inflamed states. We next inactivated the key enzyme involved in HS biosynthesis, exostosin-1 (Ext1). Silencing Ext1 resulted in a complete loss of HS biosynthesis; nonetheless, TNF-α and IL-1β stimulation of key adhesion molecules and inflammatory chemokines necessary for neutrophil or lymphocyte adhesion and TEM remained intact. Ext1 silencing reduced neutrophil arrest and markedly impaired TEM, consistent with a role of basolateral HS GAGs in directing neutrophil crossing of inflamed endothelial barriers. Strikingly, however, the TEM of effector T cells across identically Ext1-silenced HUVECs remained normal. Importantly, the biosynthesis of the main promigratory chemokines for effector T cells and neutrophils, respectively, CCL2 and CXCL1, and their vesicle distributions were also Ext1 independent. These results suggest that transmigrating neutrophils must respond to chemokines transiently presented by apical and basolateral endothelial HS GAGs. In contrast, effector T cells can integrate chemotactic TEM signals directly from intra-endothelial chemokine stores rather than from externally deposited chemokines.

  11. Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.

    PubMed

    Chen, Su-Ren; Tang, J-X; Cheng, J-M; Hao, X-X; Wang, Y-Q; Wang, X-X; Liu, Y-X

    2016-06-30

    Wingless-related MMTV integration site (WNT) proteins and several other components of the WNT signalling pathway are expressed in the murine testes. However, mice mutant for WNT signalling effector β-catenin using different Cre drivers have phenotypes that are inconsistent with each other. The complexity and overlapping expression of WNT signalling cascades have prevented researchers from dissecting their function in spermatogenesis. Depletion of the Gpr177 gene (the mouse orthologue of Drosophila Wntless), which is required for the secretion of various WNTs, makes it possible to genetically dissect the overall effect of WNTs in testis development. In this study, the Gpr177 gene was conditionally depleted in germ cells (Gpr177(flox/flox), Mvh-Cre; Gpr177(flox/flox), Stra8-Cre) and Sertoli cells (Gpr177(flox/flox), Amh-Cre). No obvious defects in fertility and spermatogenesis were observed in these three Gpr177 conditional knockout (cKO) mice at 8 weeks. However, late-onset testicular atrophy and fertility decline in two germ cell-specific Gpr177 deletion mice were noted at 8 months. In contrast, we did not observe any abnormalities of spermatogenesis and fertility, even in 8-month-old Gpr177(flox/flox), Amh-Cre mice. Elevation of reactive oxygen species (ROS) was detected in Gpr177 cKO germ cells and Sertoli cells and exhibited an age-dependent manner. However, significant increase in the activity of Caspase 3 was only observed in germ cells from 8-month-old germ cell-specific Gpr177 knockout mice. In conclusion, GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner via elevating ROS levels and triggering germ cell apoptosis.

  12. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction

    PubMed Central

    Hankey, Deborah; Zambarakji, Hadi; Pryce, Gareth; Baker, David; Calder, Virginia; Adamson, Peter; Greenwood, John

    2013-01-01

    Intraocular inflammatory diseases are a common cause of severe visual impairment and blindness. In an acute mouse model of autoimmune retinal disease, we demonstrate that treatment with the HMG-CoA reductase inhibitor, lovastatin, suppresses clinical ocular pathology, retinal vascular leakage and leukocytic infiltration into the retina. Efficacy was reversed by co-administration of mevalonolactone, the downstream product of HMG-CoA reductase, but not by squalene which is distal to isoprenoid pyrophosphate metabolites within the cholesterol biosynthetic pathway. Lovastatin treatment over 7 days, which resulted in plasma lovastatin hydroxyacid concentrations of 0.098 ± 0.03μM, did not result in splenocyte production of Th2 cytokines but did cause a small reduction in antigen-induced T cell proliferation and a decrease in the production of IFN-γ and IL-10. Thus, contrary to expected outcome we demonstrate that it is possible to dissociate the therapeutic effect of statins from their activity on the Th1/Th2 balance. Statins inhibit isoprenoid pyrophosphate synthesis, precursors required for the prenylation and posttranslational activation of Rho GTPase, a key molecule in the endothelial ICAM-1 mediated pathway that facilitates lymphocyte migration. Consistent with inhibition of leukocyte infiltration in vivo, lovastatin treatment of retinal endothelial cell monolayers in vitro leads to inhibition of lymphocyte transmigration which may, in part, account for drug efficacy. Unlike lovastatin, atorvastatin treatment failed to attenuate retinal inflammatory disease despite showing significant clinical benefit in experimental autoimmune encephalomyelitis. These data highlight the potential differential activity of statins in different inflammatory conditions and their possible therapeutic use for the treatment of human posterior uveitis. PMID:15699169

  13. Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models

    PubMed Central

    Chen, Su-Ren; Tang, J-X; Cheng, J-M; Hao, X-X; Wang, Y-Q; Wang, X-X; Liu, Y-X

    2016-01-01

    Wingless-related MMTV integration site (WNT) proteins and several other components of the WNT signalling pathway are expressed in the murine testes. However, mice mutant for WNT signalling effector β-catenin using different Cre drivers have phenotypes that are inconsistent with each other. The complexity and overlapping expression of WNT signalling cascades have prevented researchers from dissecting their function in spermatogenesis. Depletion of the Gpr177 gene (the mouse orthologue of Drosophila Wntless), which is required for the secretion of various WNTs, makes it possible to genetically dissect the overall effect of WNTs in testis development. In this study, the Gpr177 gene was conditionally depleted in germ cells (Gpr177flox/flox, Mvh-Cre; Gpr177flox/flox, Stra8-Cre) and Sertoli cells (Gpr177flox/flox, Amh-Cre). No obvious defects in fertility and spermatogenesis were observed in these three Gpr177 conditional knockout (cKO) mice at 8 weeks. However, late-onset testicular atrophy and fertility decline in two germ cell-specific Gpr177 deletion mice were noted at 8 months. In contrast, we did not observe any abnormalities of spermatogenesis and fertility, even in 8-month-old Gpr177flox/flox, Amh-Cre mice. Elevation of reactive oxygen species (ROS) was detected in Gpr177 cKO germ cells and Sertoli cells and exhibited an age-dependent manner. However, significant increase in the activity of Caspase 3 was only observed in germ cells from 8-month-old germ cell-specific Gpr177 knockout mice. In conclusion, GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner via elevating ROS levels and triggering germ cell apoptosis. PMID:27362799

  14. Does community health care require different competencies from physicians and nurses?

    PubMed Central

    2014-01-01

    Background Recently competency approach in Health Professionals’ Education (HPE) has become quite popular and for an effective competency based HPE, it is important to design the curriculum around the health care needs of the population to be served and on the expected roles of the health care providers. Unfortunately, in community settings roles of health providers tend to be described less clearly, particularly at the Primary Health Care (PHC) level where a multidisciplinary and appropriately prepared health team is generally lacking. Moreover, to tailor the education on community needs there is no substantial evidence on what specific requirements the providers must be prepared for. Methods This study has explored specific tasks of physicians and nurses employed to work in primary or secondary health care units in a context where there is a structural scarcity of community health care providers. In-depth Interviews of 11 physicians and 06 nurses working in community settings of Pakistan were conducted along with review of their job descriptions. Results At all levels of health settings, physicians’ were mostly engaged with diagnosing and prescribing medical illness of patients coming to health center and nurses depending on their employer were either providing preventive health care activities, assisting physicians or occupied in day to day management of health center. Geographical location or level of health facility did not have major effect on the roles being expected or performed, however the factors that determined the roles performed by health providers were employer expectations, preparation of health providers for providing community based care, role clarity and availability of resources including health team at health facilities. Conclusions Exploration of specific tasks of physicians and nurses working in community settings provide a useful framework to map competencies, and can help educators revisit the curricula and instructional designs

  15. Oligogalacturonide-auxin antagonism does not require posttranscriptional gene silencing or stabilization of auxin response repressors in Arabidopsis.

    PubMed

    Savatin, Daniel V; Ferrari, Simone; Sicilia, Francesca; De Lorenzo, Giulia

    2011-11-01

    α-1-4-Linked oligogalacturonides (OGs) derived from plant cell walls are a class of damage-associated molecular patterns and well-known elicitors of the plant immune response. Early transcript changes induced by OGs largely overlap those induced by flg22, a peptide derived from bacterial flagellin, a well-characterized microbe-associated molecular pattern, although responses diverge over time. OGs also regulate growth and development of plant cells and organs, due to an auxin-antagonistic activity. The molecular basis of this antagonism is still unknown. Here we show that, in Arabidopsis (Arabidopsis thaliana), OGs inhibit adventitious root formation induced by auxin in leaf explants as well as the expression of several auxin-responsive genes. Genetic, biochemical, and pharmacological experiments indicate that inhibition of auxin responses by OGs does not require ethylene, jasmonic acid, and salicylic acid signaling and is independent of RESPIRATORY BURST OXIDASE HOMOLOGUE D-mediated reactive oxygen species production. Free indole-3-acetic acid levels are not noticeably altered by OGs. Notably, OG- as well as flg22-auxin antagonism does not involve any of the following mechanisms: (1) stabilization of auxin-response repressors; (2) decreased levels of auxin receptor transcripts through the action of microRNAs. Our results suggest that OGs and flg22 antagonize auxin responses independently of Aux/Indole-3-Acetic Acid repressor stabilization and of posttranscriptional gene silencing.

  16. Does Gender Influence Electroconvulsive Therapy Sessions Required across Psychiatric Diagnoses? A 5-Year Experience from a Single Center

    PubMed Central

    Manohar, Harshini; Subramanian, Karthick; Menon, Vikas; Kattimani, Shivanand

    2017-01-01

    Context: There is a paucity of systematic data reflecting the practice of electroconvulsive therapy (ECT) from developing countries. Aim: We aimed to identify the number of ECT sessions required to yield response and gender diffeferences in the number of sessions across various diagnostic categories. Setting and Design: A record-based study from a teaching cum tertiary care hospital in South India. Subjects and Methods: Case records of patients who received modified ECT from January 2011 to January 2016 were reviewed. The sociodemographic details and ECT-related data were collected. Psychiatric diagnoses were ascertained as per the International Classification of Diseases, 10th Revision criteria. Statistical Analysis Used: Kruskal–Wallis test and Mann–Whitney U-test. Results: Among 148 patients, 82 (55.4%) had mood disorder (bipolar disorder and recurrent depressive disorder), 43 (29.1%) had schizophrenia, and 22 (14.9%) had other acute and transient psychotic disorders (ATPDs). Patients with mood disorders, schizophrenia, and other ATPD received 7.3 (± 3.8), 9.7 (± 6.1), and 5.4 (± 2.0) ECT sessions, respectively, to achieve response. There was no gender difference in the number of sessions received. Conclusion: Our findings show that number of ECT sessions required to yield response may be disorder-specific. Gender does not influence the ECT dose requirement. Variations in ECT parameters across settings may limit the generalizability of results. PMID:28694625

  17. De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly.

    PubMed

    Wang, Won-Jing; Acehan, Devrim; Kao, Chien-Han; Jane, Wann-Neng; Uryu, Kunihiro; Tsou, Meng-Fu Bryan

    2015-11-26

    Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the centriolar protein SAS-6. Here, through reconstitution of de novo synthesis in human cells, we surprisingly found that normal looking centrioles capable of duplication and ciliation can arise in the absence of SAS-6 self-oligomerization. Moreover, whereas canonically duplicated centrioles always form correctly, de novo centrioles are prone to structural errors, even in the presence of SAS-6 self-oligomerization. These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.

  18. 10 CFR 820.23 - Consent order.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Consent order. 820.23 Section 820.23 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES Enforcement Process § 820.23 Consent order. (a... consistent with the objectives of the Act and the DOE Nuclear Safety Requirements. The Director and a...

  19. What Does the WRAML2 Core Battery Measure? Utilizing Exploratory and Confirmatory Techniques to Disclose Higher Order Structure.

    PubMed

    McGill, Ryan J; Dombrowski, Stefan C

    2016-11-19

    The present study examined the factor structure of the Wide Range Assessment of Memory and Learning-Second Edition (WRAML2) core battery with participants from the normative sample aged 9 to 90 years (n = 880) using higher order exploratory and confirmatory factor analytic techniques that were not reported in the in the WRAML2 Administration and Technical Manual Exploratory factor analysis results suggested only one factor, whereas confirmatory factor analysis results favored the three factors posited by the test authors. Although model fit statistics were equivalent for the oblique, indirect hierarchical, and direct hierarchical measurement models, it was determined that the bifactor model best disclosed the influence of latent dimensions on WRAML2 manifest variables. In the three-factor bifactor model, the general factor accounted for 31% of the total variance and 69% of the common variance, whereas the three first-order factors combined accounted for 41% of the total variance and 31% of the common variance. Latent factor reliability coefficients (as estimated by ωh) indicated that only the general factor was measured with enough precision to warrant confident clinical interpretation. Implications for clinical interpretation of WRAML2 scores and the procedures utilized in the development of related measures are discussed.

  20. What does being on a community treatment orders entail? A 3-year follow-up of the OCTET CTO cohort.

    PubMed

    Rugkåsa, Jorun; Yeeles, Ksenija; Koshiaris, Constantinos; Burns, Tom

    2017-04-01

    Community Treatment Orders lack evidence of effectiveness. Very little is known about how they are used in practice and over time in terms of what it obliges patients to do and the judicial threshold for remaining on an order. To investigate CTO implementation in England in terms of the use of specified conditions, and judicial hearings; whether these change over time, and; the level of continued coercion. 36-month observational prospective study of patients on CTO in the OCTET follow-up study. The number of CTO conditions remained stable over time but consolidated around medication adherence and remaining in contact with services. Ten percent of Mental Health Tribunal Hearings and only 1 percent of Hospital Managers Hearings resulted in discharge. Twenty-seven percent of patients experienced more than one CTO episode and eighteen percent remained under compulsion until the end of follow-up. CTOs seem to be used primarily to oblige patients to take medication and stay in contact with services. There is agreement between clinical and legal judgements about their appropriateness and threshold for use. A pattern of continuous coercion for a significant group of patients raises concerns. If CTOs are to be continued to be imposed, their use should be carefully monitored with further cohort studies with long-term follow-up.

  1. Quality assurance grading guidelines for research and development at DOE facilities

    SciTech Connect

    Powell, T.B.; Morris, R.N.

    1993-01-01

    The quality assurance (QA) requirements for the US Department of Energy (DOE) are established in DOE Order 5700.6C. This order is applicable for all DOE departmental elements, management, and maintenance and operating contractors and requires that documented Quality Assurance Programs (QAPs) are prepared at all levels; it has one attachment. The DOE Office of Energy Research (DOE-ER) has issued a standard to ensure implementation of the full intent of this order in the ER community.

  2. Why does Steady-State Magnetic Reconnection have a Maximum Local Rate of Order 0.1?

    NASA Astrophysics Data System (ADS)

    Liu, Yi-Hsin; Hesse, M.; Guo, F.; Daughton, W.; Li, H.; Cassak, P. A.; Shay, M. A.

    2017-02-01

    Simulations suggest collisionless steady-state magnetic reconnection of Harris-type current sheets proceeds with a rate of order 0.1, independent of dissipation mechanism. We argue this long-standing puzzle is a result of constraints at the magnetohydrodynamic (MHD) scale. We predict the reconnection rate as a function of the opening angle made by the upstream magnetic fields, finding a maximum reconnection rate close to 0.2. The predictions compare favorably to particle-in-cell simulations of relativistic electron-positron and nonrelativistic electron-proton reconnection. The fact that simulated reconnection rates are close to the predicted maximum suggests reconnection proceeds near the most efficient state allowed at the MHD scale. The rate near the maximum is relatively insensitive to the opening angle, potentially explaining why reconnection has a similar fast rate in differing models.

  3. When the C in C P does not matter: Anatomy of order-4 C P eigenstates and their Yukawa interactions

    NASA Astrophysics Data System (ADS)

    Aranda, Alfredo; Ivanov, Igor P.; Jiménez, Enrique

    2017-03-01

    We explore the origin and Yukawa interactions of the scalars with peculiar C P properties which were recently found in a multi-Higgs model based on an order-4 C P symmetry. We relate the existence of such scalars to the enhanced freedom of defining C P , even beyond the well-known generalized C P symmetries, which arises in models with several zero-charge scalar fields. We also show that despite possessing exotic C P quantum numbers, these scalars do not have to be inert: they can have C P -conserving Yukawa interactions provided the C P acts on fermions by also mixing generations. This paper focuses on formal aspects—exposed in a pedagogical manner—and includes a brief discussion of possible phenomenological consequences.

  4. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 117(e)? 661.307... its business in an open manner as required by WIA section 117(e), by making available to the public... Local Governance Provisions § 661.307 How does the Local Board meet its requirement to conduct...

  5. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF... Requirements § 62.14830 Does this subpart require me to obtain an operating permit under title V of the...

  6. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF... Requirements § 62.14830 Does this subpart require me to obtain an operating permit under title V of the...

  7. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF... Requirements § 62.14830 Does this subpart require me to obtain an operating permit under title V of the...

  8. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF... Requirements § 62.14830 Does this subpart require me to obtain an operating permit under title V of the...

  9. 40 CFR 62.14830 - Does this subpart require me to obtain an operating permit under title V of the Clean Air Act?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... an operating permit under title V of the Clean Air Act? 62.14830 Section 62.14830 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF... Requirements § 62.14830 Does this subpart require me to obtain an operating permit under title V of the...

  10. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 117(e)? 661.307... its business in an open manner as required by WIA section 117(e), by making available to the public... Local Governance Provisions § 661.307 How does the Local Board meet its requirement to conduct...

  11. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... establishing BPAs and for orders under BPAs see 8.405-3. (b) Orders at or below the micro-purchase threshold. Ordering activities may place orders at, or below, the micro-purchase threshold with any Federal Supply.... (c) Orders exceeding the micro-purchase threshold but not exceeding the simplified...

  12. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... establishing BPAs and for orders under BPAs see 8.405-3. (b) Orders at or below the micro-purchase threshold. Ordering activities may place orders at, or below, the micro-purchase threshold with any Federal Supply.... (c) Orders exceeding the micro-purchase threshold but not exceeding the simplified...

  13. 48 CFR 8.405-1 - Ordering procedures for supplies, and services not requiring a statement of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Orders at or below the micro-purchase threshold. Ordering activities may place orders at, or below, the micro-purchase threshold with any Federal Supply Schedule contractor that can meet the agency's needs... attempt to distribute orders among contractors. (c) Orders exceeding the micro-purchase threshold but...

  14. Does Birth Order and Academic Proficiency Influence Perfectionistic Self-presentation Among Undergraduate Engineering Students? A Descriptive Analysis

    PubMed Central

    Louis, Preeti Tabitha; Kumar, Navin

    2016-01-01

    Background: Perfectionism is a multifaceted concept. It had both advantages and disadvantages. Perfectionistic traits have been associated with leadership and very intellectual people. The present study is an attempt to understand if engineering students possess perfectionistic orientation and whether it influences self-efficacy, social connectedness, and achievement motivation. Materials and Methods: The present study adopts a random sampling design to evaluate the presence of perfectionism as a personality trait among undergraduate engineering students (N = 320). Standardized inventories such as Almost Perfect Scale-Revised were administered first to identify perfectionists and second to differentiate the adaptive from the maladaptive perfectionists. Scheduled interviews were conducted with students to obtain information regarding birth order and family functioning. Results: Findings from the study reveal that there were a significant number of maladaptive perfectionists and that they experienced higher levels of personal and societal demands leading to a negative emotional well-being in comparison to the adaptive perfectionists. We also observed that first-born children were more likely to display a perfectionistic self-presentation and from scheduled interviews, we understood that paternal influences were stronger when it came to decision-making and display of conscientiousness. Conclusion: The study draws on important implications for helping students to understand perfectionism and to respond to demands of the family and societal subsystems in a positive and an adaptive manner. PMID:27833225

  15. Does Birth Order and Academic Proficiency Influence Perfectionistic Self-presentation Among Undergraduate Engineering Students? A Descriptive Analysis.

    PubMed

    Louis, Preeti Tabitha; Kumar, Navin

    2016-01-01

    Perfectionism is a multifaceted concept. It had both advantages and disadvantages. Perfectionistic traits have been associated with leadership and very intellectual people. The present study is an attempt to understand if engineering students possess perfectionistic orientation and whether it influences self-efficacy, social connectedness, and achievement motivation. The present study adopts a random sampling design to evaluate the presence of perfectionism as a personality trait among undergraduate engineering students (N = 320). Standardized inventories such as Almost Perfect Scale-Revised were administered first to identify perfectionists and second to differentiate the adaptive from the maladaptive perfectionists. Scheduled interviews were conducted with students to obtain information regarding birth order and family functioning. Findings from the study reveal that there were a significant number of maladaptive perfectionists and that they experienced higher levels of personal and societal demands leading to a negative emotional well-being in comparison to the adaptive perfectionists. We also observed that first-born children were more likely to display a perfectionistic self-presentation and from scheduled interviews, we understood that paternal influences were stronger when it came to decision-making and display of conscientiousness. The study draws on important implications for helping students to understand perfectionism and to respond to demands of the family and societal subsystems in a positive and an adaptive manner.

  16. L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers.

    PubMed

    Gavert, Nancy; Vivanti, Alessia; Hazin, John; Brabletz, Thomas; Ben-Ze'ev, Avri

    2011-01-01

    Aberrant activation of Wnt/β-catenin signaling is common in most sporadic and inherited colorectal cancer (CRC) cells leading to elevated β-catenin/TCF transactivation. We previously identified the neural cell adhesion molecule L1 as a target gene of β-catenin/TCF in CRC cells. Forced expression of L1 confers increased cell motility, invasion, and tumorigenesis, and the induction of human CRC cell metastasis to the liver. In human CRC tissue, L1 is exclusively localized at the invasive front of such tumors in a subpopulation of cells displaying nuclear β-catenin. We determined whether L1 expression confers metastatic capacities by inducing an epithelial to mesenchymal transition (EMT) and whether L1 cosegregates with cancer stem cell (CSC) markers. We found that changes in L1 levels do not affect the organization or expression of E-cadherin in cell lines, or in invading CRC tissue cells, and no changes in other epithelial or mesenchymal markers were detected after L1 transfection. The introduction of major EMT regulators (Slug and Twist) into CRC cell lines reduced the levels of E-cadherin and induced fibronectin and vimentin, but unlike L1, Slug and Twist expression was insufficient for conferring metastasis. In CRC cells L1 did not specifically cosegregate with CSC markers including CD133, CD44, and EpCAM. L1-mediated metastasis required NF-κB signaling in cells harboring either high or low levels of endogenous E-cadherin. The results suggest that L1-mediated metastasis of CRC cells does not require changes in EMT and CSC markers and operates by activating NF-κβ signaling.

  17. fMRI orientation decoding in V1 does not require global maps or globally coherent orientation stimuli.

    PubMed

    Alink, Arjen; Krugliak, Alexandra; Walther, Alexander; Kriegeskorte, Nikolaus

    2013-01-01

    The orientation of a large grating can be decoded from V1 functional magnetic resonance imaging (fMRI) data, even at low resolution (3-mm isotropic voxels). This finding has suggested that columnar-level neuronal information might be accessible to fMRI at 3T. However, orientation decodability might alternatively arise from global orientation-preference maps. Such global maps across V1 could result from bottom-up processing, if the preferences of V1 neurons were biased toward particular orientations (e.g., radial from fixation, or cardinal, i.e., vertical or horizontal). Global maps could also arise from local recurrent or top-down processing, reflecting pre-attentive perceptual grouping, attention spreading, or predictive coding of global form. Here we investigate whether fMRI orientation decoding with 2-mm voxels requires (a) globally coherent orientation stimuli and/or (b) global-scale patterns of V1 activity. We used opposite-orientation gratings (balanced about the cardinal orientations) and spirals (balanced about the radial orientation), along with novel patch-swapped variants of these stimuli. The two stimuli of a patch-swapped pair have opposite orientations everywhere (like their globally coherent parent stimuli). However, the two stimuli appear globally similar, a patchwork of opposite orientations. We find that all stimulus pairs are robustly decodable, demonstrating that fMRI orientation decoding does not require globally coherent orientation stimuli. Furthermore, decoding remained robust after spatial high-pass filtering for all stimuli, showing that fine-grained components of the fMRI patterns reflect visual orientations. Consistent with previous studies, we found evidence for global radial and vertical preference maps in V1. However, these were weak or absent for patch-swapped stimuli, suggesting that global preference maps depend on globally coherent orientations and might arise through recurrent or top-down processes related to the perception of

  18. Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway.

    PubMed

    van der Lubbe, Nils; Lim, Christina H; Meima, Marcel E; van Veghel, Richard; Rosenbaek, Lena Lindtoft; Mutig, Kerim; Danser, Alexander H J; Fenton, Robert A; Zietse, Robert; Hoorn, Ewout J

    2012-06-01

    We and others have recently shown that angiotensin II can activate the sodium chloride cotransporter (NCC) through a WNK4-SPAK-dependent pathway. Because WNK4 was previously shown to be a negative regulator of NCC, it has been postulated that angiotensin II converts WNK4 to a positive regulator. Here, we ask whether aldosterone requires angiotensin II to activate NCC and if their effects are additive. To do so, we infused vehicle or aldosterone in adrenalectomized rats that also received the angiotensin receptor blocker losartan. In the presence of losartan, aldosterone was still capable of increasing total and phosphorylated NCC twofold to threefold. The kinases WNK4 and SPAK also increased with aldosterone and losartan. A dose-dependent relationship between aldosterone and NCC, SPAK, and WNK4 was identified, suggesting that these are aldosterone-sensitive proteins. As more functional evidence of increased NCC activity, we showed that rats receiving aldosterone and losartan had a significantly greater natriuretic response to hydrochlorothiazide than rats receiving losartan only. To study whether angiotensin II could have an additive effect, rats receiving aldosterone with losartan were compared with rats receiving aldosterone only. Rats receiving aldosterone only retained more sodium and had twofold to fourfold increase in phosphorylated NCC. Together, our results demonstrate that aldosterone does not require angiotensin II to activate NCC and that WNK4 appears to act as a positive regulator in this pathway. The additive effect of angiotensin II may favor electroneutral sodium reabsorption during hypovolemia and may contribute to hypertension in diseases with an activated renin-angiotensin-aldosterone system.

  19. Recovery of Precision Grasping after Motor Cortex Lesion does not require Forced use of the Impaired Hand in Macaca mulatta

    PubMed Central

    Darling, Warren G.; Morecraft, Robert J.; Rotella, Diane L.; Pizzimenti, Marc A.; Ge, Jizhi; Stilwell-Morecraft, Kimberly S.; Zhang, Hongyu; Soliman, Hesham; Seecharan, Dave; Edwards, Ian; McNeal, David; Nudo, Randolph J.; Cheney, Paul

    2014-01-01

    We investigated whether precision grasping of small objects between the index and thumb of the impaired hand recovers without forced use after surgically placed lesions to the hand/arm areas of M1 and M1 + lateral premotor cortex (LPMC) in two monkeys. The unilateral lesions were contralateral to the monkey's preferred hand, which was established in pre-lesion testing as the hand used most often to acquire raisins in a foraging board task in which the monkey was free to use either hand to acquire the treats. The lesions initially produced a clear paresis of the contralesional hand and use of only the ipsilesional hand to acquire raisins in the foraging board task. However, beginning about 3 weeks after the lesion the monkey spontaneously began using the impaired contralesional hand in the foraging board task and increased use of that hand over the next few tests. Moreover, the monkeys clearly used precision grasp to acquire the raisins in a similar manner to pre-lesion performances, although grasp durations were longer. Although the monkeys used the contralesional hand more often than the ipsilesional hand in some post-lesion testing sessions they did not recover to use the hand as often as in pre-lesion testing when the preferred hand was used almost exclusively. These findings suggest that recovery of fine hand/digit motor function after localized damage to the lateral frontal motor areas in rhesus monkeys does not require forced use of the impaired hand. PMID:25163672

  20. Higher-Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function

    DOE PAGES

    Zeqiraj, Elton; Tian, Lei; Piggott, Christopher  A.; ...

    2015-09-03

    BRCC36 is a Zn2+-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition. The MPN+ domain protein BRCC36 associates with pseudo DUB MPN– proteins KIAA0157 or Abraxas, which are essential for BRCC36 enzymatic activity. Here, to understand the basis for BRCC36 regulation, we have solved the structure of an active BRCC36-KIAA0157 heterodimer and an inactive BRCC36 homodimer. Structural and functional characterizations show how BRCC36 is switched to an active conformation by contacts with KIAA0157. Higher-order association of BRCC36 and KIAA0157 into a dimer of heterodimers (supermore » dimers) was required for DUB activity and interaction with targeting proteins SHMT2 and RAP80. Lastly, these data provide an explanation of how an inactive pseudo DUB allosterically activates a cognate DUB partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity, subcellular localization, and biological function.« less

  1. 10 CFR 1021.321 - Requirements for environmental assessments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to prepare an EA. As required by 40 CFR 1501.4(b), DOE shall prepare an EA for a proposed DOE action... to subpart D, except that an EA is not required if DOE has decided to prepare an EIS. DOE may prepare an EA on any action at any time in order to assist agency planning and decisionmaking. (b)...

  2. Pre-ordering of interfacial water in the pathway of heterogeneous ice nucleation does not lead to a two-step crystallization mechanism

    NASA Astrophysics Data System (ADS)

    Lupi, Laura; Peters, Baron; Molinero, Valeria

    2016-12-01

    According to Classical Nucleation Theory (CNT), the transition from liquid to crystal occurs in a single activated step with a transition state controlled by the size of the crystal embryo. This picture has been challenged in the last two decades by several reports of two-step crystallization processes in which the liquid first produces pre-ordered or dense domains, within which the crystal nucleates in a second step. Pre-ordering preceding crystal nucleation has been recently reported in simulations of ice crystallization, raising the question of whether the mechanism of ice nucleation involves two steps. In this paper, we investigate the heterogeneous nucleation of ice on carbon surfaces. We use molecular simulations with efficient coarse-grained models combined with rare event sampling methods and free energy calculations to elucidate the role of pre-ordering of liquid water at the carbon surface in the reaction coordinate for heterogeneous nucleation. We find that ice nucleation proceeds through a classical mechanism, with a single barrier between liquid and crystal. The reaction coordinate that determines the crossing of the nucleation barrier is the size of the crystal nucleus, as predicted by CNT. Wetting of the critical ice nuclei within pre-ordered domains decreases the nucleation barrier, increasing the nucleation rates. The preferential pathway for crystallization involves the early creation of pre-ordered domains that are the birthplace of the ice crystallites but do not represent a minimum in the free energy pathway from liquid to ice. We conclude that a preferential pathway through an intermediate-order precursor does not necessarily result in a two-step mechanism.

  3. A discussion of higher order software concepts as they apply to functional requirements and specifications. [space shuttles and guidance

    NASA Technical Reports Server (NTRS)

    Hamilton, M.

    1973-01-01

    The entry guidance software functional requirements (requirements design phase), its architectural requirements (specifications design phase), and the entry guidance software verified code are discussed. It was found that the proper integration of designs at both the requirements and specifications levels are of high priority consideration.

  4. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.7 Q-7: How does a TARP recipient comply with the certification and...

  5. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.7 Q-7: How does a TARP recipient comply with the certification and...

  6. 31 CFR 30.7 - Q-7: How does a TARP recipient comply with the certification and disclosure requirements under...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Q-7: How does a TARP recipient comply... Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.7 Q-7: How does a TARP recipient comply with the certification and...

  7. Guide to good practices for timely orders to operators

    SciTech Connect

    1998-12-01

    This Guide to Good Practices is written to enhance understanding of, and provide direction for, Timely Orders to Operators, Chapter XV of Department of Energy (DOE) Order 5480.19, Conduct of Operations Requirements for DOE Facilities. The practices in this guide should be considered when planning or reviewing Timely Orders to Operators programs. Contractors are advised to adopt procedures that meet the intent of DOE Order 5480.19. Timely Orders to Operators is an element of an effective Conduct of Operations program. The complexity and array of activities performed in DOE facilities dictate the necessity for timely orders to operators to promote safe and efficient operations.

  8. RCN1-regulated phosphatase activity and EIN2 modulate hypocotyl gravitropism by a mechanism that does not require ethylene signaling.

    PubMed

    Muday, Gloria K; Brady, Shari R; Argueso, Cristiana; Deruère, Jean; Kieber, Joseph J; DeLong, Alison

    2006-08-01

    The roots curl in naphthylphthalamic acid1 (rcn1) mutant of Arabidopsis (Arabidopsis thaliana) has altered auxin transport, gravitropism, and ethylene response, providing an opportunity to analyze the interplay between ethylene and auxin in control of seedling growth. Roots of rcn1 seedlings were previously shown to have altered auxin transport, growth, and gravitropism, while rcn1 hypocotyl elongation exhibited enhanced ethylene response. We have characterized auxin transport and gravitropism phenotypes of rcn1 hypocotyls and have explored the roles of auxin and ethylene in controlling these phenotypes. As in roots, auxin transport is increased in etiolated rcn1 hypocotyls. Hypocotyl gravity response is accelerated, although overall elongation is reduced, in etiolated rcn1 hypocotyls. Etiolated, but not light grown, rcn1 seedlings also overproduce ethylene, and mutations conferring ethylene insensitivity restore normal hypocotyl elongation to rcn1. Auxin transport is unaffected by treatment with the ethylene precursor 1-aminocyclopropane carboxylic acid in etiolated hypocotyls of wild-type and rcn1 seedlings. Surprisingly, the ethylene insensitive2-1 (ein2-1) and ein2-5 mutations dramatically reduce gravitropic bending in hypocotyls. However, the ethylene resistant1-3 (etr1-3) mutation does not significantly affect hypocotyl gravity response. Furthermore, neither the etr1 nor the ein2 mutation abrogates the accelerated gravitropism observed in rcn1 hypocotyls, indicating that both wild-type gravity response and enhanced gravity response in rcn1 do not require an intact ethylene-signaling pathway. We therefore conclude that the RCN1 protein affects overall hypocotyl elongation via negative regulation of ethylene synthesis in etiolated seedlings, and that RCN1 and EIN2 modulate hypocotyl gravitropism and ethylene responses through independent pathways.

  9. Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS.

    PubMed

    Jensen, Laran T; Culotta, Valeria Cizewski

    2005-12-16

    Reactive oxygen species are produced as the direct result of aerobic metabolism and can cause damage to DNA, proteins, and lipids. A principal defense against reactive oxygen species involves the superoxide dismutases (SOD) that act to detoxify superoxide anions. Activation of CuZn-SODs in eukaryotic cells occurs post-translationally and is generally dependent on the copper chaperone for SOD1 (CCS), which inserts the catalytic copper cofactor and catalyzes the oxidation of a conserved disulfide bond that is essential for activity. In contrast to other eukaryotes, the nematode Caenorhabditis elegans does not contain an obvious CCS homologue, and we have found that the C. elegans intracellular CuZn-SODs (wSOD-1 and wSOD-5) are not dependent on CCS for activation when expressed in Saccharomyces cerevisiae. CCS-independent activation of CuZn-SODs is not unique to C. elegans; however, this is the first organism identified that appears to exclusively use this alternative pathway. As was found for mammalian SOD1, wSOD-1 exhibits a requirement for reduced glutathione in CCS-independent activation. Unexpectedly, wSOD-1 was inactive even in the presence of CCS when glutathione was depleted. Our investigation of the cysteine residues that form the disulfide bond in wSOD-1 suggests that the ability of wSODs to readily form this disulfide bond may be the key to obtaining high levels of activation through the CCS-independent pathway. Overall, these studies demonstrate that the CuZn-SODs of C. elegans have uniquely evolved to acquire copper without the copper chaperone and this may reflect the lifestyle of this organism.

  10. DOE standard: Firearms safety

    SciTech Connect

    1996-02-01

    Information in this document is applicable to all DOE facilities, elements, and contractors engaged in work that requires the use of firearms as provided by law or contract. The standard in this document provides principles and practices for implementing a safe and effective firearms safety program for protective forces and for non-security use of firearms. This document describes acceptable interpretations and methods for meeting Order requirements.

  11. Requirements for canisters used for delivery of spent nuclear fuel and associated materials to DOE (Department of Energy) under standard disposal contracts

    SciTech Connect

    Not Available

    1990-06-01

    The Department of Energy (DOE) is studying prospective changes to the waste acceptance criteria contained in the Standard Contract which involve consideration of the possible acceptance of failed fuel, consolidated fuel rods, compacted structural parts resulting from at reactor consolidation operations, and other non-fuel bearing materials on the same scheduling basis as used for standard fuel under the existing Standard Contract. During the course of these studies it has become clear that all such forms of spent fuel and related wastes would have to be delivered to DOE (and stored at the reactor) in a container having an envelope about the same as the fuel assemblies from which the fuel forms originated. Thus, the first objective of the DOE effort has been to develop draft requirements for canisters to be used by utilities (and others) to deliver the foregoing forms of spent fuel and related wastes. These draft requirements have been completed and are included in this paper.

  12. Quantifying and Addressing the DOE Material Reactivity Requirements with Analysis and Testing of Hydrogen Storage Materials & Systems

    SciTech Connect

    Khalil, Y. F.

    2012-04-30

    The objective of this project is to examine safety aspects of candidate hydrogen storage materials and systems being developed in the DOE Hydrogen Program. As a result of this effort, the general DOE safety target will be given useful meaning by establishing a link between the characteristics of new storage materials and the satisfaction of safety criteria. This will be accomplished through the development and application of formal risk analysis methods, standardized materials testing, chemical reactivity characterization, novel risk mitigation approaches and subscale system demonstration. The project also will collaborate with other DOE and international activities in materials based hydrogen storage safety to provide a larger, highly coordinated effort.

  13. 20 CFR 641.220 - Does title I of WIA require the SCSEP to use OAA funds for individuals who are not eligible for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... authorized under the OAA? 641.220 Section 641.220 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Does title I of WIA require the SCSEP to use... for individuals seeking workforce development services by linking the One-Stop partners in the One...

  14. 20 CFR 662.280 - Does title I require One-Stop partners to use their funds for individuals who are not eligible...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... authorized under the partner's program? 662.280 Section 662.280 Employees' Benefits EMPLOYMENT AND TRAINING... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Does title I require One-Stop partners to use... workforce development services by linking the One-Stop partners in the One-Stop delivery system. While the...

  15. 25 CFR 63.13 - What does the Indian Child Protection and Family Violence Prevention Act require of the Bureau of...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Prevention Act require of the Bureau of Indian Affairs and Indian tribes or tribal organizations receiving... GOVERNMENT INDIAN CHILD PROTECTION AND FAMILY VIOLENCE PREVENTION Minimum Standards of Character and Suitability for Employment § 63.13 What does the Indian Child Protection and Family Violence Prevention Act...

  16. 14 CFR 39.9 - What if I operate an aircraft or use a product that does not meet the requirements of an...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false What if I operate an aircraft or use a product that does not meet the requirements of an airworthiness directive? 39.9 Section 39.9 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT...

  17. 31 CFR 363.28 - Does Public Debt reserve the right to require that any TreasuryDirect ® transaction be conducted...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Does Public Debt reserve the right to require that any TreasuryDirect ® transaction be conducted in paper form? 363.28 Section 363.28 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE...

  18. 20 CFR 641.220 - Does title I of WIA require the SCSEP to use OAA funds for individuals who are not eligible for...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Coordination With... training services under title I of WIA provided that the SCSEP participants have each received a community... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Does title I of WIA require the SCSEP to...

  19. 20 CFR 641.220 - Does title I of WIA require the SCSEP to use OAA funds for individuals who are not eligible for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Coordination With... training services under title I of WIA provided that the SCSEP participants have each received a community... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Does title I of WIA require the SCSEP to...

  20. 20 CFR 661.307 - How does the Local Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false How does the Local Board meet its requirement... Section 661.307 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) STATEWIDE AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE...

  1. 20 CFR 661.207 - How does the State Board meet its requirement to conduct business in an open manner under the...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to conduct business in an open manner under the âsunshine provisionâ of WIA section 111(g)? 661.207... AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT State Governance Provisions § 661.207 How does the State Board meet its requirement to conduct...

  2. 25 CFR 39.219 - What happens if a residential program does not maintain residency levels required by this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of service per week as certified in its submitted school calendar. For each month that a school does not maintain 25 percent of the residency shown in its submitted calendar, the school will lose...

  3. 39 CFR 762.42 - Request for substitute disbursement postal money orders; requirements for undertaking of indemnity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Request for substitute disbursement postal money... POSTAL SERVICE POSTAL SERVICE DEBT OBLIGATIONS; DISBURSEMENT POSTAL MONEY ORDERS DISBURSEMENT POSTAL MONEY ORDERS Issuance of Substitutes for Lost, Destroyed, Mutilated, and Defaced Disbursement...

  4. 39 CFR 762.42 - Request for substitute disbursement postal money orders; requirements for undertaking of indemnity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Request for substitute disbursement postal money... POSTAL SERVICE POSTAL SERVICE DEBT OBLIGATIONS; DISBURSEMENT POSTAL MONEY ORDERS DISBURSEMENT POSTAL MONEY ORDERS Issuance of Substitutes for Lost, Destroyed, Mutilated, and Defaced Disbursement...

  5. Cross-Modal Plasticity in Higher-Order Auditory Cortex of Congenitally Deaf Cats Does Not Limit Auditory Responsiveness to Cochlear Implants

    PubMed Central

    Baumhoff, Peter; Tillein, Jochen; Lomber, Stephen G.; Hubka, Peter; Kral, Andrej

    2016-01-01

    over the unused cortex and reassigns it to the remaining senses. Therefore, cross-modal plasticity might conflict with restoration of auditory function with cochlear implants. It is unclear whether the cross-modally reorganized auditory areas lose auditory responsiveness. We show that the presence of cross-modal plasticity in a higher-order auditory area does not reduce auditory responsiveness of that area. Visual reorganization was moderate, spatially scattered and there were no interactions between cross-modally reorganized visual and auditory inputs. These results indicate that cross-modal reorganization is less detrimental for neurosensory restoration than previously thought. PMID:27277796

  6. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File, in...

  7. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File, in...

  8. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File, in...

  9. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File, in...

  10. 10 CFR 490.602 - Special orders.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Special orders. 490.602 Section 490.602 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Investigations and Enforcement § 490.602 Special orders. (a) DOE may require by general or special orders that any person— (1) File, in...

  11. 78 FR 62930 - Order Providing Broker-Dealers a Temporary Exemption From the Requirements of Certain New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... paragraph (j)(2) to Rule 15c3-3 regarding the treatment of customers' free credit balances. Additionally... 8, 1998 staff no-action letter that addresses the net capital treatment of proprietary accounts of... requirements from Rule 15c3-2 (customers' free credit balances), including the requirement that...

  12. 41 CFR 102-118.390 - On what basis does GSA grant a waiver to the prepayment audit requirement?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... prepayment audit requirement? GSA issues waivers to the prepayment audit requirement based on: (a) Cost-effectiveness; (b) Government efficiency; (c) Public interest; or (d) Other factors the Administrator of General...

  13. 41 CFR 102-118.390 - On what basis does GSA grant a waiver to the prepayment audit requirement?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... prepayment audit requirement? GSA issues waivers to the prepayment audit requirement based on: (a) Cost-effectiveness; (b) Government efficiency; (c) Public interest; or (d) Other factors the Administrator of General...

  14. 41 CFR 102-118.390 - On what basis does GSA grant a waiver to the prepayment audit requirement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... prepayment audit requirement? GSA issues waivers to the prepayment audit requirement based on: (a) Cost-effectiveness; (b) Government efficiency; (c) Public interest; or (d) Other factors the Administrator of General...

  15. 41 CFR 102-118.390 - On what basis does GSA grant a waiver to the prepayment audit requirement?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... prepayment audit requirement? GSA issues waivers to the prepayment audit requirement based on: (a) Cost-effectiveness; (b) Government efficiency; (c) Public interest; or (d) Other factors the Administrator of General...

  16. 41 CFR 102-118.390 - On what basis does GSA grant a waiver to the prepayment audit requirement?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... prepayment audit requirement? GSA issues waivers to the prepayment audit requirement based on: (a) Cost-effectiveness; (b) Government efficiency; (c) Public interest; or (d) Other factors the Administrator of General...

  17. 34 CFR 461.44 - How does a State request a waiver of the maintenance of effort requirement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... effort requirement? 461.44 Section 461.44 Education Regulations of the Offices of the Department of... request a waiver of the maintenance of effort requirement? An SEA seeking a waiver of the maintenance of effort requirement in § 461.42 shall— (a) Submit to the Secretary a request for a waiver; and (b)...

  18. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... consortium requirement? 636.11 Section 636.11 Education Regulations of the Offices of the Department of... consortium requirement? (a) An applicant may request that the Secretary waive the requirement for a planning consortium by submitting as part of the application a request that includes the following: (1) The...

  19. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... consortium requirement? 636.11 Section 636.11 Education Regulations of the Offices of the Department of... consortium requirement? (a) An applicant may request that the Secretary waive the requirement for a planning consortium by submitting as part of the application a request that includes the following: (1) The...

  20. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... consortium requirement? 636.11 Section 636.11 Education Regulations of the Offices of the Department of... consortium requirement? (a) An applicant may request that the Secretary waive the requirement for a planning consortium by submitting as part of the application a request that includes the following: (1) The...

  1. 34 CFR 636.11 - How does an applicant request a waiver of the planning consortium requirement?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... consortium requirement? 636.11 Section 636.11 Education Regulations of the Offices of the Department of... consortium requirement? (a) An applicant may request that the Secretary waive the requirement for a planning consortium by submitting as part of the application a request that includes the following: (1) The...

  2. 40 CFR 721.160 - Notification requirements for new chemical substances subject to section 5(e) orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... chemical substances subject to section 5(e) orders. 721.160 Section 721.160 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Expedited Process for Issuing Significant New Use Rules for Selected Chemical Substances...

  3. 40 CFR 721.160 - Notification requirements for new chemical substances subject to section 5(e) orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... chemical substances subject to section 5(e) orders. 721.160 Section 721.160 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Expedited Process for Issuing Significant New Use Rules for Selected Chemical Substances...

  4. Teaching to the Test…or Testing to Teach: Exams Requiring Higher Order Thinking Skills Encourage Greater Conceptual Understanding

    ERIC Educational Resources Information Center

    Jensen, Jamie L.; McDaniel, Mark A.; Woodard, Steven M.; Kummer, Tyler A.

    2014-01-01

    In order to test the effect of exam-question level on fostering student conceptual understanding, low-level and high-level quizzes and exams were administered in two sections of an introductory biology course. Each section was taught in a high-level inquiry based style but was assigned either low-level questions (memory oriented) on the quizzes…

  5. 48 CFR 52.212-5 - Contract Terms and Conditions Required To Implement Statutes or Executive Orders-Commercial Items.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... law or Executive orders applicable to acquisitions of commercial items: (1) 52.222-50, Combating... Notice of Total Set-Aside for Economically Disadvantaged Women-Owned Small Business (EDWOSB) Concerns (APR 2011). ___(23) 52.219-30 Notice of Total Set-Aside for Women-Owned Small Business (WOSB) Concerns...

  6. 48 CFR 52.212-5 - Contract Terms and Conditions Required To Implement Statutes or Executive Orders-Commercial Items.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... law or Executive orders applicable to acquisitions of commercial items: (1) 52.222-50, Combating..., Notice of Set-Aside for Economically Disadvantaged Women-Owned Small Business (EDWOSB) Concerns (APR 2012) (15 U.S.C. 637(m)). ___(25) 52.219-30, Notice of Set-Aside for Women-Owned Small Business (WOSB...

  7. 48 CFR 52.212-5 - Contract Terms and Conditions Required To Implement Statutes or Executive Orders-Commercial Items.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... law or Executive orders applicable to acquisitions of commercial items: (1) 52.222-50, Combating..., Notice of Set-Aside for Economically Disadvantaged Women-Owned Small Business (EDWOSB) Concerns (Jul 2013) (15 U.S.C. 637(m)). __ (25) 52.219-30, Notice of Set-Aside for Women-Owned Small Business (WOSB...

  8. 48 CFR 52.212-5 - Contract Terms and Conditions Required To Implement Statutes or Executive Orders-Commercial Items.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... flow down any FAR clause, other than those in this paragraph (e)(1) of this paragraph in a subcontract for commercial items. Unless otherwise indicated below, the extent of the flow down shall be as...) (Pub. L. 110-247). Flow down required in accordance with paragraph (e) of FAR clause 52.226-6. (xiv)...

  9. Selection of a Propulsion System for Jason-CS in Order to Fulfil Space Debris Mitigation Requirements for ESA Project

    NASA Astrophysics Data System (ADS)

    Barthen, Bjoern; Beck, Jan; Duske, Norbert; Francis, Richard; Koeble, Klaus-Peter

    2013-08-01

    For two decades, the mission Topex-Poseidon and its successor mission Jason/Ocean Surface Topography Mission provide satellite data for the analysis of sea topography, wave heights and wind speeds. For the continuation of service mission Jason-CS, ESA's choice to rely on the CryoSat-2 platform design permits re-use of a well established product and proven processes. An industrial consortium led by Astrium GmbH has built the satellite CryoSat-2 which for over three years successfully provides altimeter measurements of the polar ice cap thickness evolutions. This platform is perfectly suited for accommodation of the Jason-CS instruments. Unlike CryoSat-2, Jason-CS is required to perform a post-mission disposal according to the Requirements for Space Debris Mitigation for ESA Projects. This paper discusses different technologies in terms of efficiency, feasibility and accommodation, aiming at minimizing necessary spacecraft design modifications.

  10. 48 CFR 252.212-7001 - Contract terms and conditions required to implement statutes or Executive orders applicable to...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., Requirements Relating to Compensation of Former DoD Officials (SEP 2011) (Section 847 of Pub. L. 110-181). (2...) (15 U.S.C. 637). (5) __ 252.219-7004, Small Business Subcontracting Plan (Test Program) (JAN 2011) (15...) (41 U.S.C. chapter 83, E.O. 10582). (ii) __ Alternate I (OCT 2011) of 252.225-7001. (7) __ 252.225...

  11. 45 CFR 286.270 - What happens if the Tribe does not satisfy the quarterly reporting requirements?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL TANF PROVISIONS Data Collection and Reporting Requirements... determine that a Tribe has not submitted to us a complete and accurate Tribal TANF Data Report within the... rate targets since the data from the Tribal TANF Data Report is required to calculate...

  12. 36 CFR 1234.22 - How does an agency request a waiver from a requirement in this part?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... September 28, 2005; and (3) The application of roof requirements in §§ 1234.10 and 1234.12 to underground... the information specified in paragraphs (c), (d), and/or (e) of this section to the Director, Space... for waiver of roof requirements for underground facility. The agency's waiver request must...

  13. 36 CFR 1234.22 - How does an agency request a waiver from a requirement in this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... September 28, 2005; and (3) The application of roof requirements in §§ 1234.10 and 1234.12 to underground... the information specified in paragraphs (c), (d), and/or (e) of this section to the Director, Space... for waiver of roof requirements for underground facility. The agency's waiver request must...

  14. 20 CFR 655.1110 - What requirements does the NRDAA impose in the filing of an Attestation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Requirements Must a Facility Meet to Employ H-1C Nonimmigrant Workers as Registered Nurses? § 655.1110 What...) requires a prospective employer of H-1C nurses to attest to the following: (1) That it qualifies as a “facility” (See § 655.1111); (2) That employment of H-1C nurses will not adversely affect the wages...

  15. Just-in-Time Logistics: Does It Fulfill the Surface Navy’s Requirements to Support the National Military Strategy

    DTIC Science & Technology

    2001-06-01

    most prominent of the changes implemented from industry has been the Just - in - Time logistics model. This model requires reduced inventories and greater...repair parts distribution capabilities, and conditions of the battlefield with fleet requirements will provide a framework for determining if Just - in - Time logistics

  16. Measurement and Development of Humanware and Technoware Competencies in Order to Meet Pintle Chain Product Requirements in Bandung Manufacture Polytechnic

    NASA Astrophysics Data System (ADS)

    Akbar, Jodi; Akbar, Muhammad; Irianto, Dradjad

    2016-02-01

    Politeknik Manufaktur Bandung (Bandung Manufacture Polytechnic) is a polytechnic education that is not only to educate their students, but also manufactures order from customers at its teaching factory. This polytechnic is usually not responsive with the number of reject due to amateur operators from newcomer students. However, customers will be displeased if the reject rate is too high which can cause delay of delivery. At the foundry section, pintle chain is a product that has the highest amount of quantity but the lowest product standard fulfilment. Realizing this problem, it is a strong need to give more focus on quality improvement. The polytechnic considers that bad quality is not only related to low level of humanware (operator) but also related to low level of technoware (machine and equipment). In this research, QFD model was used as a tool for identifying target of improvement of non conforming factors of humanware and technoware using UNESCAP's technometric model. An improvement was done by implementing new scheduling strategy at foundry unit in order to minimize waiting time from molding to pouring process because of deterioration problem. This strategy provides an opportunity to reduce completion times about 50% and waiting time about 95% compared to the existing scheduling strategy.

  17. Medicare and Medicaid programs; changes in provider and supplier enrollment, ordering and referring, and documentation requirements; and changes in provider agreements. Final rule.

    PubMed

    2012-04-27

    This final rule finalizes several provisions of the Affordable Care Act implemented in the May 5, 2010 interim final rule with comment period. It requires all providers of medical or other items or services and suppliers that qualify for a National Provider Identifier (NPI) to include their NPI on all applications to enroll in the Medicare and Medicaid programs and on all claims for payment submitted under the Medicare and Medicaid programs. In addition, it requires physicians and other professionals who are permitted to order and certify covered items and services for Medicare beneficiaries to be enrolled in Medicare. Finally, it mandates document retention and provision requirements on providers and supplier that order and certify items and services for Medicare beneficiaries.

  18. Does Intrasession Concurrent Strength and Aerobic Training Order Influence Training-Induced Explosive Strength and V[Combining Dot Above]O2max in Prepubescent Children?

    PubMed

    Alves, Ana R; Marta, Carlos C; Neiva, Henrique P; Izquierdo, Mikel; Marques, Mário C

    2016-12-01

    Alves, AR, Marta, C, Neiva, HP, Izquierdo, M, and Marques, MC. Does intrasession concurrent strength and aerobic training order influence training-induced explosive strength and V[Combining Dot Above]O2max in prepubescent children?. J Strength Cond Res 30(12): 3267-3277, 2016-The aim of this study was to analyze the interference of strength and aerobic training order over an 8-week period on explosive skills and maximal oxygen uptake (V[Combining Dot Above]O2max) in prepubescent children. One hundred twenty-eight prepubescent children aged 10-11 years (10.9 ± 0.5 years) were randomly selected and assigned to 1 of the 3 groups: intrasession concurrent aerobic before (GAS: n = 39) or after strength training (GSA: n = 45) or control group (GC: n = 44; no training program). The GC maintained their baseline level performance, and training-induced differences were found in the experimental groups. Increases were found in the 1-kg and 3-kg medicine ball throws: GAS: +3%, +5.5%, p ≤ 0.05, p < 0.001; GSA: +5.7%, +8.7%, p < 0.001, respectively; in the counter movement jump height and standing long jump length: GAS: +6.5%, +3.4%, p ≤ 0.05; GSA: +7%, +4.5%, p < 0.001, respectively; in the 20-m shuttle-run time: GAS: +2.3%; GSA: +4.6%, p < 0.001; and, in the V[Combining Dot Above]O2max: GAS: +7.3%, p < 0.001; GSA: +3.8%, p < 0.001 from pretraining to post-training. All programs were effective, but GSA produced better results than GAS for muscle strength variables, and GAS produced better results than GSA for aerobic capacity variables. The present study explored an unknown issue and added useful information to the literature in this area. These training methods should be taken into consideration to optimize explosive strength and cardiorespiratory fitness training in school-based programs and sports club programs.

  19. Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins

    PubMed Central

    Mondal, Samiran; Begum, Nasim A.; Hu, Wenjun; Honjo, Tasuku

    2016-01-01

    Activation-induced cytidine deaminase (AID) is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes. Although both the N and C termini of AID have unique functions in DNA cleavage and recombination, respectively, during SHM and CSR, their molecular mechanisms are poorly understood. Using a bimolecular fluorescence complementation (BiFC) assay combined with glycerol gradient fractionation, we revealed that the AID C terminus is required for a stable dimer formation. Furthermore, AID monomers and dimers form complexes with distinct heterogeneous nuclear ribonucleoproteins (hnRNPs). AID monomers associate with DNA cleavage cofactor hnRNP K whereas AID dimers associate with recombination cofactors hnRNP L, hnRNP U, and Serpine mRNA-binding protein 1. All of these AID/ribonucleoprotein associations are RNA-dependent. We propose that AID’s structure-specific cofactor complex formations differentially contribute to its DNA-cleavage and recombination functions. PMID:26929374

  20. High-order adaptive optics requirements for direct detection of extrasolar planets: Application to the SPHERE instrument.

    PubMed

    Fusco, T; Rousset, G; Sauvage, J-F; Petit, C; Beuzit, J-L; Dohlen, K; Mouillet, D; Charton, J; Nicolle, M; Kasper, M; Baudoz, P; Puget, P

    2006-08-21

    The detection of extrasolar planets implies an extremely high-contrast, long-exposure imaging capability at near infrared and probably visible wavelengths. We present here the core of any Planet Finder instrument, that is, the extreme adaptive optics (XAO) subsystem. The level of AO correction directly impacts the exposure time required for planet detection. In addition, the capacity of the AO system to calibrate all the instrument static defects ultimately limits detectivity. Hence, the extreme AO system has to adjust for the perturbations induced by the atmospheric turbulence, as well as for the internal aberrations of the instrument itself. We propose a feasibility study for an extreme AO system in the frame of the SPHERE (Spectro-Polarimetry High-contrast Exoplanet Research) instrument, which is currently under design and should equip one of the four VLT 8-m telescopes in 2010.