KSC Shuttle ground turnaround evaluation

NASA Technical Reports Server (NTRS)

Ragusa, J. M.

1983-01-01

Payload/mission development, processing flows, facilities/systems, and the various environments to which a payload is exposed during ground processing are described. These considerations are important for payload design and ground processing requirements development.

Radar Detection Models in Computer Supported Naval War Games

DTIC Science & Technology

1979-06-08

revealed a requirement for the effective centralized manage- ment of computer supported war game development and employment in the U.S. Navy. A...considerations and supports the requirement for centralized Io 97 management of computerized war game development . Therefore it is recommended that a central...managerial and fiscal authority be estab- lished for computerized tactical war game development . This central authority should ensure that new games

Shuttle/Agena study. Volume 2, part 3: Preliminary test plans

NASA Technical Reports Server (NTRS)

1972-01-01

Proposed testing for the Agena tug program is based upon best estimates of shuttle and Agena tug requirements and upon the Agena configuration currently envisioned to meet these requirements. The proposed tests are presented in development, qualification, system, and launch base test plans. These plans are based upon generalized requirements and assumed situations. The limitations of this study precluded all but minimal consideration of related shuttle orbiter and shuttle ground systems. The test plans include provisions for all testing from major component to systems level, identified as necessary to aid in confirmation of the modified Agena configuration for the space tug; considerations that crew safety requirements and new environmental conditions from shuttle interface effects do impose some new Agena testing requirements; considerations that many existing Agena flight-qualified components will be utilized and qualification testing will be minimal; testing not only for the Agena tug but also for new or modified items of handling or servicing equipment for supporting the Agena factory-to-launch sequence; and the assembly of required testing into a sequence-ordered series of events.

Design and fabrication considerations for stainless steel liquid helium jackets surrounding SCRF cavities

NASA Astrophysics Data System (ADS)

Bonnema, E. C.; Cunningham, E. K.; Rumel, J. D.

2014-01-01

The Department of Energy requires its subcontractors to meet 10 CFR 851 Appendix A Part 4 for all new pressure vessels and pressure piping. The stainless steel pressure vessel boundaries surrounding SCRF cavities fall under this requirement. Methods for meeting this requirement include design and fabrication of the pressure vessels to meet the requirements of the ASME Boiler & Pressure Vessel Code Section VIII Division 1 or Division 2. Design considerations include determining whether the configuration of the SCRF cavity can be accommodated under the rules of Division 1 or must be analyzed under Division 2 Part 4 Design by Rule Requirements or Part 5 Design by Analysis Requirements. Regardless of the Division or Part choice, designers will find the rules of the ASME Code require thicker pressure boundary members, larger welds, and additional non-destructive testing and quality assurance requirements. These challenges must be met and overcome by the fabricator through the development of robust, detailed, and repeatable manufacturing processes. In this paper we discuss the considerations for stainless steel pressure vessels that must meet the ASME Code and illustrate the discussion with examples from direct experience fabricating such vessels.

An integrated optimum design approach for high speed prop-rotors including acoustic constraints

NASA Technical Reports Server (NTRS)

Chattopadhyay, Aditi; Wells, Valana; Mccarthy, Thomas; Han, Arris

1993-01-01

The objective of this research is to develop optimization procedures to provide design trends in high speed prop-rotors. The necessary disciplinary couplings are all considered within a closed loop multilevel decomposition optimization process. The procedures involve the consideration of blade-aeroelastic aerodynamic performance, structural-dynamic design requirements, and acoustics. Further, since the design involves consideration of several different objective functions, multiobjective function formulation techniques are developed.

Development of an Effective School-Based Financial Management Profile in Malaysia: The Delphi Method Application

ERIC Educational Resources Information Center

Radzi, Norfariza Mohd; Ghani, Muhammad Faizal A.; Siraj, Saedah

2015-01-01

The agenda for national development requires a persistent improvement in education as a tool for creating knowledgeable human capital, highly skilled labour, a high technology society and ultimately a highly civilized nation for the future challenging world. It requires considerable financial and technical investment as well as effective and…

Development of a waste collection system for the space shuttle.

NASA Technical Reports Server (NTRS)

Behrend, A. F., Jr.; Swider, J. E., Jr.

1972-01-01

The development of a waste collection system to accommodate both male and female crew members for the space shuttle is discussed. The waste collection system, with emphasis on the collection and transfer of urine, is described. Human-interface requirements, zero-gravity influences and effects, and operational considerations required for total system design are discussed.

Low-Cost Rapid Usability Testing: Its Application in Both Product Development and System Implementation.

PubMed

Kushniruk, Andre; Borycki, Elizabeth

2017-01-01

In recent years there has been considerable discussion around the need for certification and regulation of healthcare information technology (IT). In particular, the usability of the products being developed needs to be evaluated. This has included the application of standards designed to ensure the process of system development is user-centered and takes usability into consideration while a product is being developed. In addition to this, in healthcare, organizations in the United States and Europe have also addressed the need and requirement for product certification. However, despite these efforts there are continued reports of unusable and unsafe implementations. In this paper we discuss the need to not only include (and require) usability testing in the one-time development process of health IT products (such as EHRs), but we also argue for the need to additionally develop specific usability standards and requirements for usability testing during the implementation of vendor products (i.e. post product development) in healthcare settings. It is further argued that health IT products that may have been certified regarding their development process will still require application of usability testing in the process of implementing them in real hospital settings in order to ensure usability and safety. This is needed in order to ensure that the final result of both product development and implementation processes take into account and apply the latest usability principles and methods.

Software requirements for the study of contextual classifiers and label imperfections

NASA Technical Reports Server (NTRS)

Chittineni, C. B.

1979-01-01

The software requirements for the study of contextual classifiers and imperfections in the labels are presented. In particular, the requirements are described for updating the posteriori probability of the picture element under consideration using information from its local neighborhood, designing the Fisher classifier, and other required routines. Only the necessary equations are given for the development of software.

Development of full regeneration establishment models for the forest vegetation simulator

Treesearch

John D. Shaw

2015-01-01

For most simulation modeling efforts, the goal of model developers is to produce simulations that are the best representations of realism as possible. Achieving this goal commonly requires a considerable amount of data to set the initial parameters, followed by validation and model improvement – both of which require even more data. The Forest Vegetation Simulator (FVS...

YAdumper: extracting and translating large information volumes from relational databases to structured flat files.

PubMed

Fernández, José M; Valencia, Alfonso

2004-10-12

Downloading the information stored in relational databases into XML and other flat formats is a common task in bioinformatics. This periodical dumping of information requires considerable CPU time, disk and memory resources. YAdumper has been developed as a purpose-specific tool to deal with the integral structured information download of relational databases. YAdumper is a Java application that organizes database extraction following an XML template based on an external Document Type Declaration. Compared with other non-native alternatives, YAdumper substantially reduces memory requirements and considerably improves writing performance.

Hydrogen aircraft technology

NASA Technical Reports Server (NTRS)

Brewer, G. D.

1991-01-01

A comprehensive evaluation is conducted of the technology development status, economics, commercial feasibility, and infrastructural requirements of LH2-fueled aircraft, with additional consideration of hydrogen production, liquefaction, and cryostorage methods. Attention is given to the effects of LH2 fuel cryotank accommodation on the configurations of prospective commercial transports and military airlifters, SSTs, and HSTs, as well as to the use of the plentiful heatsink capacity of LH2 for innovative propulsion cycles' performance maximization. State-of-the-art materials and structural design principles for integral cryotank implementation are noted, as are airport requirements and safety and environmental considerations.

Averaging business cycles vs. myopia: Do we need a long term vision when developing IRP?

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, C.; Gupta, P.C.

1995-05-01

Utility demand forecasting is inherently imprecise due to the number of uncertainties resulting from business cycles, policy making, technology breakthroughs, national and international political upheavals and the limitations of the forecasting tools. This implies that revisions based primarily on recent experience could lead to unstable forecasts. Moreover, new planning tools are required that provide an explicit consideration of uncertainty and lead to flexible and robust planning tools are required that provide an explicit consideration of uncertainty and lead to flexible and robust planning decisions.

Multimegawatt electric propulsion system design considerations

NASA Technical Reports Server (NTRS)

Gilland, J. H.; Myers, Roger M.; Patterson, Michael J.

1991-01-01

Piloted Mars Mission Requirements of relatively short trip times and low initial mass in Earth orbit as identified by the NASA Space Exploration Initiative, indicate the need for multimegawatt electric propulsion systems. The design considerations and results for two thruster types, the argon ion, and hydrogen magnetoplasmadynamic thrusters, are addressed in terms of configuration, performance, and mass projections. Preliminary estimates of power management and distribution for these systems are given. Some assessment of these systems' performance in a reference Space Exploration Initiative piloted mission are discussed. Research and development requirements of these systems are also described.

Device considerations for development of conductance-based biosensors

PubMed Central

Lee, Kangho; Nair, Pradeep R.; Scott, Adina; Alam, Muhammad A.; Janes, David B.

2009-01-01

Design and fabrication of electronic biosensors based on field-effect-transistor (FET) devices require understanding of interactions between semiconductor surfaces and organic biomolecules. From this perspective, we review practical considerations for electronic biosensors with emphasis on molecular passivation effects on FET device characteristics upon immobilization of organic molecules and an electrostatic model for FET-based biosensors. PMID:24753627

Technology developments under consideration for future ground systems

NASA Astrophysics Data System (ADS)

Drewes, G. W. J.

A review is conducted of those areas of ground-system related technology which require for their appropriate development funding provided by ESA. ESA will, in this connection, financially support the development of a coaxial S and X band feed horn for use with its 15-m antenna for Villafranca and Carnarvon. With respect to RF techology, it is found that the required RF components and subsystems will be available, and, consequently, ESA will not provide any funds for developments in this area. Other sectors examined with respect to possible developments requiring ESA funding are related to modulation/demodulation, spacecraft position, data handling, timing, and development and standardization.

Design and Psychometric Considerations for Assessments of Speaking Proficiency: The English Language Development Assessment (ELDA) as Illustration

ERIC Educational Resources Information Center

Ferrara, Steve

2008-01-01

The No Child Left Behind Act of 2001 requires all states to assess the English proficiency of English language learners each school year. Under Title I and Title III of No Child Left Behind, states are required to measure the annual growth of students' English language development in reading, listening, writing, and speaking and in comprehension…

System requirements specification for SMART structures mode

NASA Technical Reports Server (NTRS)

1992-01-01

Specified here are the functional and informational requirements for software modules which address the geometric and data modeling needs of the aerospace structural engineer. The modules are to be included as part of the Solid Modeling Aerospace Research Tool (SMART) package developed for the Vehicle Analysis Branch (VAB) at the NASA Langley Research Center (LaRC). The purpose is to precisely state what the SMART Structures modules will do, without consideration of how it will be done. Each requirement is numbered for reference in development and testing.

Pahoa geothermal industrial park. Engineering and economic analysis for direct applications of geothermal energy in an industrial park at Pahoa, Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreau, J.W.

1980-12-01

This engineering and economic study evaluated the potential for developing a geothermal industrial park in the Puna District near Pahoa on the Island of Hawaii. Direct heat industrial applications were analyzed from a marketing, engineering, economic, environmental, and sociological standpoint to determine the most viable industries for the park. An extensive literature search produced 31 existing processes currently using geothermal heat. An additional list was compiled indicating industrial processes that require heat that could be provided by geothermal energy. From this information, 17 possible processes were selected for consideration. Careful scrutiny and analysis of these 17 processes revealed three thatmore » justified detailed economic workups. The three processes chosen for detailed analysis were: an ethanol plant using bagasse and wood as feedstock; a cattle feed mill using sugar cane leaf trash as feedstock; and a papaya processing facility providing both fresh and processed fruit. In addition, a research facility to assess and develop other processes was treated as a concept. Consideration was given to the impediments to development, the engineering process requirements and the governmental support for each process. The study describes the geothermal well site chosen, the pipeline to transmit the hydrothermal fluid, and the infrastructure required for the industrial park. A conceptual development plan for the ethanol plant, the feedmill and the papaya processing facility was prepared. The study concluded that a direct heat industrial park in Pahoa, Hawaii, involves considerable risks.« less

Considerations affecting the additional weight required in mass balance of ailerons

NASA Technical Reports Server (NTRS)

Diehl, W S

1937-01-01

This paper is essentially a consideration of mass balance of ailerons from a preliminary design standpoint, in which the extra weight of the mass counterbalance is the most important phase of the problem. Equations are developed for the required balance weight for a simple aileron and this weight is correlated with the mass-balance coefficient. It is concluded the location of the c.g. of the basic aileron is of paramount importance and that complete mass balance imposes no great weight penalty if the aileron is designed to have its c.g. inherently near to the hinge axis.

An Australian Perspective on School Leadership Preparation and Development: Credentials or Self-Management?

ERIC Educational Resources Information Center

Gurr, David; Drysdale, Lawrie

2015-01-01

This paper provides a review of school leadership preparation and development in Australia through considering the requirements for becoming a principal, how leadership preparation and development occurs, and consideration of recent developments to provide an Australian standard for school leaders. Australian educators have relied mostly on a…

Physical Requirements of the Workplace: Research Considerations for Personnel Selection.

ERIC Educational Resources Information Center

Hogan, Joyce C.

Personnel selection processes for physically demanding jobs often discriminate against women, minorities, and handicapped individuals. Developing and validating job-related performance tests requires the assessment of the physical demands of a job and of the same physical capabilities in individuals. Job analysis is a systematic assessment…

24 CFR 3280.109 - Room requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS Planning Considerations § 3280.109 Room requirements. (a) Every manufactured home shall have at least one living area with not less than 150 sq. ft. of gross floor area. (b) Rooms designed for sleeping purposes shall have a minimum gross square foot floor...

Practical considerations in clinical strategy to support the development of injectable drug-device combination products for biologics.

PubMed

Li, Zhaoyang; Easton, Rachael

2018-01-01

The development of an injectable drug-device combination (DDC) product for biologics is an intricate and evolving process that requires substantial investments of time and money. Consequently, the commercial dosage form(s) or presentation(s) are often not ready when pivotal trials commence, and it is common to have drug product changes (manufacturing process or presentation) during clinical development. A scientifically sound and robust bridging strategy is required in order to introduce these changes into the clinic safely. There is currently no single developmental paradigm, but a risk-based hierarchical approach has been well accepted. The rigor required of a bridging package depends on the level of risk associated with the changes. Clinical pharmacokinetic/pharmacodynamic comparability or outcome studies are only required when important changes occur at a late stage. Moreover, an injectable DDC needs to be user-centric, and usability assessment in real-world clinical settings may be required to support the approval of a DDC. In this review, we discuss the common issues during the manufacturing process and presentation development of an injectable DDC and practical considerations in establishing a clinical strategy to address these issues, including key elements of clinical studies. We also analyze the current practice in the industry and review relevant and status of regulatory guidance in the DDC field.

Practical considerations in clinical strategy to support the development of injectable drug-device combination products for biologics

PubMed Central

Easton, Rachael

2018-01-01

ABSTRACT The development of an injectable drug-device combination (DDC) product for biologics is an intricate and evolving process that requires substantial investments of time and money. Consequently, the commercial dosage form(s) or presentation(s) are often not ready when pivotal trials commence, and it is common to have drug product changes (manufacturing process or presentation) during clinical development. A scientifically sound and robust bridging strategy is required in order to introduce these changes into the clinic safely. There is currently no single developmental paradigm, but a risk-based hierarchical approach has been well accepted. The rigor required of a bridging package depends on the level of risk associated with the changes. Clinical pharmacokinetic/pharmacodynamic comparability or outcome studies are only required when important changes occur at a late stage. Moreover, an injectable DDC needs to be user-centric, and usability assessment in real-world clinical settings may be required to support the approval of a DDC. In this review, we discuss the common issues during the manufacturing process and presentation development of an injectable DDC and practical considerations in establishing a clinical strategy to address these issues, including key elements of clinical studies. We also analyze the current practice in the industry and review relevant and status of regulatory guidance in the DDC field. PMID:29035675

Research and Development, Technology Requirements, and Use of Existing Space Assets

NASA Technical Reports Server (NTRS)

Grey, Jerry; Rowell, Larry

1999-01-01

Technology requirements are addressed in three categories: (1) Passenger-carrying STS(s); (2) orbital facilities (including on-orbit operations such as servicing) and human factors (crew and passenger training and recreation, on-orbit environmental control, etc.); and (3) ground infrastructure. An example tourism trip scenario is used in discussing possible targets for technology development activities. Some general comments are made as are considerations for other working groups.

Special Operations and the Soldier System: Critical Acquisition Issues

DTIC Science & Technology

1992-03-01

continues to exercise considerable interest in Ranger related material requirements through its responsibilities for all infantry combat development...UNCLASSIFIED 22a NAME OF RESPONSIBLE INDIVIDUAL 22b TELEPHONE (Include Area code) 22c OFFICE SYMBOL Dr Richard B. Doyle 408-646-3302 AS/Dy DD FORM 1473,84 MAR...34 study. Chapter V discusses the acquisition responsibilities of USSOCOM, detailing the evolving relationship with the Army requirement development

Considerations in development of expert systems for real-time space applications

NASA Technical Reports Server (NTRS)

Murugesan, S.

1988-01-01

Over the years, demand on space systems has increased tremendously and this trend will continue for the near future. Enhanced capabilities of space systems, however, can only be met with increased complexity and sophistication of onboard and ground systems. Artificial Intelligence and expert system techniques have great potential in space applications. Expert systems could facilitate autonomous decision making, improve in-orbit fault diagnosis and repair, enhance performance and reduce reliance on ground support. However, real-time expert systems, unlike conventional off-line consultative systems, have to satisfy certain special stringent requirements before they could be used for onboard space applications. Challenging and interesting new environments are faced while developing expert system space applications. This paper discusses the special characteristics, requirements and typical life cycle issues for onboard expert systems. Further, it also describes considerations in design, development, and implementation which are particularly important to real-time expert systems for space applications.

Requirements for Modeling and Simulation for Space Medicine Operations: Preliminary Considerations

NASA Technical Reports Server (NTRS)

Dawson, David L.; Billica, Roger D.; Logan, James; McDonald, P. Vernon

2001-01-01

The NASA Space Medicine program is now developing plans for more extensive use of high-fidelity medical Simulation systems. The use of simulation is seen as means to more effectively use the limited time available for astronaut medical training. Training systems should be adaptable for use in a variety of training environments, including classrooms or laboratories, space vehicle mockups, analog environments, and in microgravity. Modeling and simulation can also provide the space medicine development program a mechanism for evaluation of other medical technologies under operationally realistic conditions. Systems and procedures need preflight verification with ground-based testing. Traditionally, component testing has been accomplished, but practical means for "human in the loop" verification of patient care systems have been lacking. Medical modeling and simulation technology offer potential means to accomplish such validation work. Initial considerations in the development of functional requirements and design standards for simulation systems for space medicine are discussed.

Basic Principles of Electrical Network Reliability Optimization in Liberalised Electricity Market

NASA Astrophysics Data System (ADS)

Oleinikova, I.; Krishans, Z.; Mutule, A.

2008-01-01

The authors propose to select long-term solutions to the reliability problems of electrical networks in the stage of development planning. The guide lines or basic principles of such optimization are: 1) its dynamical nature; 2) development sustainability; 3) integrated solution of the problems of network development and electricity supply reliability; 4) consideration of information uncertainty; 5) concurrent consideration of the network and generation development problems; 6) application of specialized information technologies; 7) definition of requirements for independent electricity producers. In the article, the major aspects of liberalized electricity market, its functions and tasks are reviewed, with emphasis placed on the optimization of electrical network development as a significant component of sustainable management of power systems.

Current Practices in Hosting Non-US Pharmacy Students at US Pharmacy Schools in Experiential Clerkships

PubMed Central

Al-Dahir, Sara; Alsharif, Naser Z.; Gleason, Shaun E.; Tofade, Toyin; Flores, Emily K.; Katz, Michael; Dornblaser, Emily K.

2017-01-01

Objective: To provide specific considerations for hosting non-U.S. pharmacy students at U.S.-based colleges/schools of pharmacy (C/SOP) for experiential clerkships and training. Findings: A literature review (2000-2016) in PubMed, Google Scholar and IPA databases was conducted using specific keywords. Recommendations and future directions for development of experiential rotations for non-U.S. students in U.S. experiential rotations are presented for both the home and host country. Summary articles and best practices across the disciplines, as well as expert opinion, were found across U.S. models for hosting non-U.S. students in advanced practice rotations in the medical disciplines. Consistent themes regarding legal agreements, acculturation, standardized calendars and social and safety considerations were considered for inclusion in the final document. Conclusion: Development of a successful experiential rotation/training for non-U.S. students requires consideration for well-developed objectives, qualified preceptors, multitude of legal and cultural considerations and recommendations for longevity and sustainability. PMID:29302084

Siting Issues for Solar Thermal Power Plants with Small Community Applications

NASA Technical Reports Server (NTRS)

Holbeck, J. J.; Ireland, S. J.

1978-01-01

Technologies for solar thermal plants are being developed to provide energy alternatives for the future. Implementation of these plants requires consideration of siting issues as well as power system technology. While many conventional siting considerations are applicable, there is also a set of unique siting issues for solar thermal plants. Early experimental plants will have special siting considerations. The siting issues associated with small, dispersed solar thermal power plants in the 1 to 10 MWe power range for utility/small community applications are considered. Some specific requirements refer to the first 1 MWe engineering experiment for the Small Power Systems Applications (SPSA) Project. The siting issues themselves are discussed in three categories: (1) system resource requirements, (2) environmental effects on the system, and (3) potential impact of the plant on the environment. Within these categories, specific issues are discussed in a qualitative manner. Examples of limiting factors for some issues are taken from studies of other solar systems.

NPDES Permit Writers' Course

EPA Pesticide Factsheets

The objective of the NPDES permit writers' course is to provide the basic regulatory framework and technical considerations that support the development of wastewater discharge permits as required under the NPDES Permit Program.

Loads and Structural Dynamics Requirements for Spaceflight Hardware

NASA Technical Reports Server (NTRS)

Schultz, Kenneth P.

2011-01-01

The purpose of this document is to establish requirements relating to the loads and structural dynamics technical discipline for NASA and commercial spaceflight launch vehicle and spacecraft hardware. Requirements are defined for the development of structural design loads and recommendations regarding methodologies and practices for the conduct of load analyses are provided. As such, this document represents an implementation of NASA STD-5002. Requirements are also defined for structural mathematical model development and verification to ensure sufficient accuracy of predicted responses. Finally, requirements for model/data delivery and exchange are specified to facilitate interactions between Launch Vehicle Providers (LVPs), Spacecraft Providers (SCPs), and the NASA Technical Authority (TA) providing insight/oversight and serving in the Independent Verification and Validation role. In addition to the analysis-related requirements described above, a set of requirements are established concerning coupling phenomena or other interaction between structural dynamics and aerodynamic environments or control or propulsion system elements. Such requirements may reasonably be considered structure or control system design criteria, since good engineering practice dictates consideration of and/or elimination of the identified conditions in the development of those subsystems. The requirements are included here, however, to ensure that such considerations are captured in the design space for launch vehicles (LV), spacecraft (SC) and the Launch Abort Vehicle (LAV). The requirements in this document are focused on analyses to be performed to develop data needed to support structural verification. As described in JSC 65828, Structural Design Requirements and Factors of Safety for Spaceflight Hardware, implementation of the structural verification requirements is expected to be described in a Structural Verification Plan (SVP), which should describe the verification of each structural item for the applicable requirements. The requirement for and expected contents of the SVP are defined in JSC 65828. The SVP may also document unique verifications that meet or exceed these requirements with Technical Authority approval.

Recent advances in estimating protein and energy requirements of ruminants

USDA-ARS?s Scientific Manuscript database

Considerable efforts have been made in gathering scientific data and developing feeding systems for ruminant animals in the last 50 years. Future endeavours should target the assessment, interpretation, and integration of the accumulated knowledge to develop nutrition models in a holistic and pragma...

Australian Wine Tourism: Establishing a Career Path at the Cellar Door

ERIC Educational Resources Information Center

Williams, Kim Marianne

2011-01-01

Wine tourism in Australia has grown substantially in recent years and contributes to employment opportunities in regional areas. To meet the requirements of this growing sector, workers need a considerable degree of skill-specific training; development of wine tourism personnel will be required. This article examines challenging human resource…

Five Steps for Developing Effective Transition Plans for High School Students with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Szidon, Katherine; Ruppar, Andrea; Smith, Leann

2015-01-01

The Individuals With Disabilities Education Act (IDEA; 2006) requires schools to develop transition plans for students with disabilities, beginning at age 16, if not before. For students with autism spectrum disorder (ASD), the transition planning process includes unique considerations. This article describes five steps for developing effective…

C-Band Airport Surface Communications System Standards Development. Phase II Final Report. Volume 1: Concepts of Use, Initial System Requirements, Architecture, and AeroMACS Design Considerations

NASA Technical Reports Server (NTRS)

Hall, Edward; Isaacs, James; Henriksen, Steve; Zelkin, Natalie

2011-01-01

This report is provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-Band and L-Band Communications Standard Development and was based on direction provided by FAA project-level agreements for New ATM Requirements-Future Communications. Task 7 included two subtasks. Subtask 7-1 addressed C-band (5091- to 5150-MHz) airport surface data communications standards development, systems engineering, test bed and prototype development, and tests and demonstrations to establish operational capability for the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2 focused on systems engineering and development support of the L-band digital aeronautical communications system (L-DACS). Subtask 7-1 consisted of two phases. Phase I included development of AeroMACS concepts of use, requirements, architecture, and initial high-level safety risk assessment. Phase II builds on Phase I results and is presented in two volumes. Volume I (this document) is devoted to concepts of use, system requirements, and architecture, including AeroMACS design considerations. Volume II describes an AeroMACS prototype evaluation and presents final AeroMACS recommendations. This report also describes airport categorization and channelization methodologies. The purposes of the airport categorization task were (1) to facilitate initial AeroMACS architecture designs and enable budgetary projections by creating a set of airport categories based on common airport characteristics and design objectives, and (2) to offer high-level guidance to potential AeroMACS technology and policy development sponsors and service providers. A channelization plan methodology was developed because a common global methodology is needed to assure seamless interoperability among diverse AeroMACS services potentially supplied by multiple service providers.

AAFE man-made noise experiment project. Volume 3: Appendices

NASA Technical Reports Server (NTRS)

1974-01-01

Management and operational considerations involved in the project to measure man-made electromagnetic noise at earth orbital altitudes are discussed. The subjects considered are: (1) launch and orbit of the Scout D vehicles, (2) experiment management, (3) receiver scanning considerations, (4) data handling, and (5) threshold measurements. The storage requirements for a high resolution, complete data storage library are defined. Mathematical models of signal detection probability are developed.

Electronic Excitation in Molecular Collisions: Structural, Dynamic and Kinetic Considerations.

DTIC Science & Technology

1981-08-01

electronically excited species are examined. The problem is studied both in general terms (i.e., the development of the required theoretical framework ) and in application to specific systems. (Author)

Electronic Excitation in Molecular Collisions: Structural, Dynamic and Kinetic Considerations.

DTIC Science & Technology

1980-09-01

electronically excited species are examined. The problem is studied both in general terms (i.e., the development of the required theoretical framework ) and in application to specific systems. (Author)

Electronic Excitation in Molecular Collisions: Structural, Dynamic and Kinetic Considerations.

DTIC Science & Technology

1979-09-01

electronically excited species are examined. The problem is studied both in general terms (i.e., the development of the required theoretical framework ) and in application to specific systems. (Author)

Electronic Excitation in Molecular Collisions: Structural, Dynamic and Kinetic Considerations.

DTIC Science & Technology

electronically excited specied are examined. The problem is studied both in general terms (i.e., the development of the required theoretical framework ) and in application to specific systems. (Author)

Design considerations for a gas microcontroller

NASA Technical Reports Server (NTRS)

Ritter, D. A.

1986-01-01

Some of the design problems that are now being addressed in consideration of a microcontroller for the upcoming GAS payload are discussed. Microcontrollers will be used to run the experiments and to collect and store the data from those experiments. Some of the requirements for a microcontroller are to be small, lightweight, have low power consumption, and high reliability. Some of the solutions that were developed to meet these design requirements are discussed. At present, the experiment is still in the design stage and the final design may change from what is presented here. The search for new integrated circuits which will do all that is needed all in one package continues.

Open Questions Limiting the Practice of Interorganizational Development.

ERIC Educational Resources Information Center

Schermerhorn, John R., Jr.

1981-01-01

Summarizes the open questions that must be answered by researchers if practioners of interorganizational development are to have adequate planning-and-action guidelines. Suggests the questions should help practitioners become more sensitive to potential action considerations that may require special thought and attention until a firmer knowledge…

24 CFR 3285.101 - Fire separation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Fire separation. 3285.101 Section... DEVELOPMENT MODEL MANUFACTURED HOME INSTALLATION STANDARDS Pre-Installation Considerations § 3285.101 Fire separation. Fire separation distances must be in accordance with the requirements of Chapter 6 of NFPA 501A...

Development of Anticipatory Automobile Crash Sensors

DOT National Transportation Integrated Search

1971-06-30

A COMPREHENSIVE EXAMINATION IS CARRIED OUT TO DETERMINE THE BASIC SYSTEM CONSTRAINTS AND REQUIRED OPERATIONAL CHARACTERISTICS FOR ANTICIPATORY SENSING OF IMPENDING AUTOMOBILE CRASHES. THIS IS FOLLOWED BY CONSIDERATION OF A WIDE VARIETY OF POSSIBLE SE...

Infrastructure considerations

NASA Astrophysics Data System (ADS)

Lovelace, Uriel; Sumrall, Phil; Pritchard, Brian

1989-04-01

An evaluation is made of performance requirements and technology development prospects for the logistical capacity entailed by manned space exploration. While the Space Shuttle will suffice for the launch of crews to a LEO Space Station, in support of such exploration missions, cargo transport will require 500-1000 tonne annual payload capacity launchers. As a first step toward satisfaction of such requirements, NASA has undertaken the development of the Shuttle-C unmanned Space Shuttle derivative. This will be followed by the Shuttle-Z derivative-family, aimed at meeting the needs of Mars missions. Joint USAF/NASA Advanced Launch System development will allow a given launch to place 91 tonnes in LEO.

THE SCHOOL SITE--ITS SELECTION, ANALYSIS, DEVELOPMENT AND MAINTENANCE.

ERIC Educational Resources Information Center

BRUNING, WALTER F.

SCHOOL ADMINISTRATORS AND COMMUNITY PLANNERS CAN AID THE SCHOOL SITE SELECTION PROCESS BY WORKING TOGETHER ON A COMMUNITY MASTER PLAN. MANY COMMUNITIES HAVE DEVELOPED SUCH A PLAN UNDER THE STATE AND FEDERALLY AIDED 701 PROGRAM. SOUND SITE SELECTION PRINCIPLES REQUIRE CONSIDERATION OF OTHER FACTORS THAN STUDENT POPULATION DISTRIBUTION. IDEALLY…

Leadership for the Development Function in the Two-Year College.

ERIC Educational Resources Information Center

Rowh, Mark

Identifying and obtaining external funding for two-year colleges require an approach which is consistent with the particular scope and mission of such institutions and which takes into consideration the priorities of funding agencies. Faced with divergent functions and financial/staffing constraints, two-year college development officers must not…

Manned remote work station development article, executive summary

NASA Technical Reports Server (NTRS)

1979-01-01

The mission requirements for the manned remote work station (MRWS) flight article and the manned remote work station open cherry picker development test article is defined. Considerations are given for the near, mid, and far term use of the MRWS with emphasis on its ultimate application: constructing the Solar Power Satellite.

Principal Development: Self-Directed Project Efficacy

ERIC Educational Resources Information Center

Piggot-Irvine, Eileen

2011-01-01

The inclusion of self-directed projects as an element within a New Zealand principal development programme was designed to reflect increasing support internationally for such a context-specific "inquiry" approach. The results reported in this article suggest that considerable clarity is required for such projects if they are to realize…

Development of an integrated configuration management/flight director system for piloted STOL approaches

NASA Technical Reports Server (NTRS)

Hoh, R. H.; Klein, R. H.; Johnson, W. A.

1977-01-01

A system analysis method for the development of an integrated configuration management/flight director system for IFR STOL approaches is presented. Curved descending decelerating approach trajectories are considered. Considerable emphasis is placed on satisfying the pilot centered requirements (acceptable workload) as well as the usual guidance and control requirements (acceptable performance). The Augmentor Wing Jet STOL Research Aircraft was utilized to allow illustration by example, and to validate the analysis procedure via manned simulation.

Value-Based Requirements Traceability: Lessons Learned

NASA Astrophysics Data System (ADS)

Egyed, Alexander; Grünbacher, Paul; Heindl, Matthias; Biffl, Stefan

Traceability from requirements to code is mandated by numerous software development standards. These standards, however, are not explicit about the appropriate level of quality of trace links. From a technical perspective, trace quality should meet the needs of the intended trace utilizations. Unfortunately, long-term trace utilizations are typically unknown at the time of trace acquisition which represents a dilemma for many companies. This chapter suggests ways to balance the cost and benefits of requirements traceability. We present data from three case studies demonstrating that trace acquisition requires broad coverage but can tolerate imprecision. With this trade-off our lessons learned suggest a traceability strategy that (1) provides trace links more quickly, (2) refines trace links according to user-defined value considerations, and (3) supports the later refinement of trace links in case the initial value consideration has changed over time. The scope of our work considers the entire life cycle of traceability instead of just the creation of trace links.

Alternative Fuels Data Center: Charging Plug-In Electric Vehicles at Home

Science.gov Websites

Infrastructure Development Charging at Home Multi-Unit Dwelling Charging Charging in Public Workplace Charging complex requires additional considerations and may be more similar to public charging than to charging at , requiring no additional cost or installation, provided that a power outlet on a dedicated branch circuit is

Saturn S-2 production operations techniques: Production welding. Volume 1: Bulkhead welding

NASA Technical Reports Server (NTRS)

Abel, O. G.

1970-01-01

The complex Saturn S-2 welding processes and procedures required considerable development and refinement to establish a production capability that could consistently produce aluminum alloy welds within specified requirements. The special processes and techniques are defined that were established for the welding of gore-to-gore and manhole- or closeout-to-gore.

Modeling and Performance Considerations for Automated Fault Isolation in Complex Systems

NASA Technical Reports Server (NTRS)

Ferrell, Bob; Oostdyk, Rebecca

2010-01-01

The purpose of this paper is to document the modeling considerations and performance metrics that were examined in the development of a large-scale Fault Detection, Isolation and Recovery (FDIR) system. The FDIR system is envisioned to perform health management functions for both a launch vehicle and the ground systems that support the vehicle during checkout and launch countdown by using suite of complimentary software tools that alert operators to anomalies and failures in real-time. The FDIR team members developed a set of operational requirements for the models that would be used for fault isolation and worked closely with the vendor of the software tools selected for fault isolation to ensure that the software was able to meet the requirements. Once the requirements were established, example models of sufficient complexity were used to test the performance of the software. The results of the performance testing demonstrated the need for enhancements to the software in order to meet the demands of the full-scale ground and vehicle FDIR system. The paper highlights the importance of the development of operational requirements and preliminary performance testing as a strategy for identifying deficiencies in highly scalable systems and rectifying those deficiencies before they imperil the success of the project

Nurse-computer performance. Considerations for the nurse administrator.

PubMed

Mills, M E; Staggers, N

1994-11-01

Regulatory reporting requirements and economic pressures to create a unified healthcare database are leading to the development of a fully computerized patient record. Nursing staff members will be responsible increasingly for using this technology, yet little is known about the interaction effect of staff characteristics and computer screen design on on-line accuracy and speed. In examining these issues, new considerations are raised for nurse administrators interested in facilitating staff use of clinical information systems.

Theoretical study of gas hydrate decomposition kinetics--model development.

PubMed

Windmeier, Christoph; Oellrich, Lothar R

2013-10-10

In order to provide an estimate of the order of magnitude of intrinsic gas hydrate dissolution and dissociation kinetics, the "Consecutive Desorption and Melting Model" (CDM) is developed by applying only theoretical considerations. The process of gas hydrate decomposition is assumed to comprise two consecutive and repetitive quasi chemical reaction steps. These are desorption of the guest molecule followed by local solid body melting. The individual kinetic steps are modeled according to the "Statistical Rate Theory of Interfacial Transport" and the Wilson-Frenkel approach. All missing required model parameters are directly linked to geometric considerations and a thermodynamic gas hydrate equilibrium model.

Overview of the Design, Development, and Application of Nickel-hydrogen Batteries

NASA Technical Reports Server (NTRS)

Thaller, Lawrence H.; Zimmerman, Albert H.

2003-01-01

This document provides an overview of the design, development, and application of nickel-hydrogen (Ni-H2) battery technology for aerospace applications. It complements and updates the information presented in NASA RP-1314, NASA Handbook for Nickel- Hydrogen Batteries, published in 1993. Since that time, nickel-hydrogen batteries have become widely accepted for aerospace energy storage requirements and much more has been learned. The intent of this document is to capture some of that additional knowledge. This document addresses various aspects of nickel-hydrogen technology including the electrochemical reactions, cell component design, and selection considerations; overall cell and battery design considerations; charge control considerations; and manufacturing issues that have surfaced over the years that nickel-hydrogen battery technology has been the major energy storage technology for geosynchronous and low-Earth-orbiting satellites.

Earth resources data acquisition sensor study

NASA Technical Reports Server (NTRS)

Grohse, E. W.

1975-01-01

The minimum data collection and data processing requirements are investigated for the development of water monitoring systems, which disregard redundant and irrelevant data and process only those data predictive of the onset of significant pollution events. Two approaches are immediately suggested: (1) adaptation of a presently available ambient air monitoring system developed by TVA, and (2) consideration of an air, water, and radiological monitoring system developed by the Georgia Tech Experiment Station. In order to apply monitoring systems, threshold values and maximum allowable rates of change of critical parameters such as dissolved oxygen and temperature are required.

Air-to-air radar flight testing

NASA Astrophysics Data System (ADS)

Scott, Randall E.

1988-06-01

This volume in the AGARD Flight Test Techniques Series describes flight test techniques, flight test instrumentation, ground simulation, data reduction and analysis methods used to determine the performance characteristics of a modern air-to-air (a/a) radar system. Following a general coverage of specification requirements, test plans, support requirements, development and operational testing, and management information systems, the report goes into more detailed flight test techniques covering a/a radar capabilities of: detection, manual acquisition, automatic acquisition, tracking a single target, and detection and tracking of multiple targets. There follows a section on additional flight test considerations such as electromagnetic compatibility, electronic countermeasures, displays and controls, degraded and backup modes, radome effects, environmental considerations, and use of testbeds. Other sections cover ground simulation, flight test instrumentation, and data reduction and analysis. The final sections deal with reporting and a discussion of considerations for the future and how they may affect radar flight testing.

Solar Design Workbook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Franta, G.; Baylin, F.; Crowther, R.

1981-06-01

This Solar Design Workbook presents solar building design applications for commercial buildir^s. The book is divided into four sections. The first section describes the variety of solar applications in buildings including conservation aspects, solar fundamentals, passive systems, active systems, daylighting, and other solar options. Solar system design evaluation techniques including considerations for building energy requirements, passive systems, active systems, and economics are presented in Section II. The third section attempts to assist the designer in the building design process for energy conservation and solar applications including options and considerations for pre-design, design, and post-design phases. The information required for themore » solar design proee^ has not been fully developed at this time. Therefore, Section III is incomplete, but an overview of the considerations with some of the design proces elements is presented. Section IV illustrates ease studies that utilize solar applications in the building design.« less

Benefits estimates of highway capital improvements with uncertain parameters.

DOT National Transportation Integrated Search

2006-01-01

This report warrants consideration in the development of goals, performance measures, and standard cost-benefit methodology required of transportation agencies by the Virginia 2006 Appropriations Act. The Virginia Department of Transportation has beg...

Technology development for lunar base water recycling

NASA Technical Reports Server (NTRS)

Schultz, John R.; Sauer, Richard L.

1992-01-01

This paper will review previous and ongoing work in aerospace water recycling and identify research activities required to support development of a lunar base. The development of a water recycle system for use in the life support systems envisioned for a lunar base will require considerable research work. A review of previous work on aerospace water recycle systems indicates that more efficient physical and chemical processes are needed to reduce expendable and power requirements. Development work on biological processes that can be applied to microgravity and lunar environments also needs to be initiated. Biological processes are inherently more efficient than physical and chemical processes and may be used to minimize resupply and waste disposal requirements. Processes for recovering and recycling nutrients such as nitrogen, phosphorus, and sulfur also need to be developed to support plant growth units. The development of efficient water quality monitors to be used for process control and environmental monitoring also needs to be initiated.

Patient centric formulations for paediatrics and geriatrics: Similarities and differences.

PubMed

Hanning, Sara M; Lopez, Felipe L; Wong, Ian C K; Ernest, Terry B; Tuleu, Catherine; Orlu Gul, Mine

2016-10-30

Paediatrics and geriatrics both represent highly heterogenous populations and require special consideration when developing appropriate dosage forms. This paper discusses similarities, differences and considerations with respect to the development of appropriate medicine formulations for paediatrics and geriatrics. Arguably the most significant compliance challenge in older people is polypharmacy, whereas for children the largest barrier is taste. Pharmaceutical technology has progressed rapidly and technologies including FDCs, multi-particulates and orodispersible dosage forms provide unprecedented opportunities to develop novel and appropriate formulations for both old and new drugs. However, it is important for the formulation scientists to work closely with patients, carers and clinicians to develop such formulations for both the paediatric and geriatric population. Copyright © 2016 Elsevier B.V. All rights reserved.

A diagnostic prototype of the potable water subsystem of the Space Station Freedom ECLSS

NASA Technical Reports Server (NTRS)

Lukefahr, Brenda D.; Rochowiak, Daniel M.; Benson, Brian L.; Rogers, John S.; Mckee, James W.

1989-01-01

In analyzing the baseline Environmental Control and Life Support System (ECLSS) command and control architecture, various processes are found which would be enhanced by the use of knowledge based system methods of implementation. The most suitable process for prototyping using rule based methods are documented, while domain knowledge resources and other practical considerations are examined. Requirements for a prototype rule based software system are documented. These requirements reflect Space Station Freedom ECLSS software and hardware development efforts, and knowledge based system requirements. A quick prototype knowledge based system environment is researched and developed.

Manned remote work station development article. Volume 2: Simulation requirements. Appendix A: Open cherry picker development test articles specification

NASA Technical Reports Server (NTRS)

1979-01-01

A manned remote work station (MRWS) mission scenario, broken down into the three time phases was selected as the basis for analysis of the MRWS flight article requirements and concepts. The mission roles for the three time phases, supporting tradeoff and evaluation studies, was used to identify key issues requiring simulation. The MRWS is discussed in terms of its capability to perform such operations as support of Spacelab experiments, servicing and repair of satellites, and construction. Future considerations for the use of the MRWS are also given.

Polymerase Chain Reaction/Rapid Methods Are Gaining a Foothold in Developing Countries.

PubMed

Ragheb, Suzan Mohammed; Jimenez, Luis

Detection of microbial contamination in pharmaceutical raw materials and finished products is a critical factor to guarantee their safety, stability, and potency. Rapid microbiological methods-such as polymerase chain reaction-have been widely applied to clinical and food quality control analysis. However, polymerase chain reaction applications to pharmaceutical quality control have been rather slow and sporadic. Successful implementation of these methods in pharmaceutical companies in developing countries requires important considerations to provide sensitive and robust assays that will comply with good manufacturing practices. In recent years several publications have encouraged the application of molecular techniques in the microbiological assessment of pharmaceuticals. One of these techniques is polymerase chain reaction (PCR). The successful application of PCR in the pharmaceutical industry in developing countries is governed by considerable factors and requirements. These factors include the setting up of a PCR laboratory and the choice of appropriate equipment and reagents. In addition, the presence of well-trained analysts and establishment of quality control and quality assurance programs are important requirements. The pharmaceutical firms should take into account these factors to allow better chances for regulatory acceptance and wide application of this technique. © PDA, Inc. 2014.

Biofuels Research at EPA

EPA Science Inventory

The development of sustainable and clean biofuels is a national priority. To do so requires a life-cycle approach that includes consideration of feedstock production and logistics, and biofuel production, distribution, and end use. The US Environmental Protection Agency is suppor...

Multi-trip vehicle routing and scheduling problem with time window in real life

NASA Astrophysics Data System (ADS)

Sze, San-Nah; Chiew, Kang-Leng; Sze, Jeeu-Fong

2012-09-01

This paper studies a manpower scheduling problem with multiple maintenance operations and vehicle routing considerations. Service teams located at a common service centre are required to travel to different customer sites. All customers must be served within given time window, which are known in advance. The scheduling process must take into consideration complex constraints such as a meal break during the team's shift, multiple travelling trips, synchronisation of service teams and working shifts. The main objective of this study is to develop a heuristic that can generate high quality solution in short time for large problem instances. A Two-stage Scheduling Heuristic is developed for different variants of the problem. Empirical results show that the proposed solution performs effectively and efficiently. In addition, our proposed approximation algorithm is very flexible and can be easily adapted to different scheduling environments and operational requirements.

High-speed aerodynamic design of space vehicle and required hypersonic wind tunnel facilities

NASA Astrophysics Data System (ADS)

Sakakibara, Seizou; Hozumi, Kouichi; Soga, Kunio; Nomura, Shigeaki

Problems associated with the aerodynamic design of space vehicles with emphasis of the role of hypersonic wind tunnel facilities in the development of the vehicle are considered. At first, to identify wind tunnel and computational fluid dynamics (CFD) requirements, operational environments are postulated for hypervelocity vehicles. Typical flight corridors are shown with the associated flow density: real gas effects, low density flow, and non-equilibrium flow. Based on an evaluation of these flight regimes and consideration of the operational requirements, the wind tunnel testing requirements for the aerodynamic design are examined. Then, the aerodynamic design logic and optimization techniques to develop and refine the configurations in a traditional phased approach based on the programmatic design of space vehicle are considered. Current design methodology for the determination of aerodynamic characteristics for designing the space vehicle, i.e., (1) ground test data, (2) numerical flow field solutions and (3) flight test data, are also discussed. Based on these considerations and by identifying capabilities and limits of experimental and computational methods, the role of a large conventional hypersonic wind tunnel and the high enthalpy tunnel and the interrelationship of the wind tunnels and CFD methods in actual aerodynamic design and analysis are discussed.

A Case Study of the Land of Enchantment Teacher Quality Partnership for Aspiring School Administrators

ERIC Educational Resources Information Center

Mizell, Kimberly

2013-01-01

What are the considerations required to developing a leadership preparation program, and a professional development plan that bridges the theoretical perspective to the practitioners' perspective? An inquiry was conducted to gain insight into the individual perspectives of three diverse women administrators who participated in the Land of…

What Should We Teach the Teachers? Identifying the Learning Priorities of Clinical Supervisors

ERIC Educational Resources Information Center

Bearman, Margaret; Tai, Joanna; Kent, Fiona; Edouard, Vicki; Nestel, Debra; Molloy, Elizabeth

2018-01-01

Clinicians who teach are essential for the health workforce but require faculty development to improve their educational skills. Curricula for faculty development programs are often based on expert frameworks without consideration of the learning priorities as defined by clinical supervisors themselves. We sought to inform these curricula by…

EDUCATIONAL SPECIFICATIONS FOR THE NORTH CAMPUS OF SEATTLE COMMUNITY COLLEGE.

ERIC Educational Resources Information Center

MCGUFFEY, C.W.; AND OTHERS

THE NORTH CAMPUS IS ONE OF THREE UNITS PROPOSED FOR THE SEATTLE COMMUNITY COLLEGE. A TEAM OF CONSULTANTS AND STAFF COMMITTEES DEVELOPED THIS DESCRIPTION OF THE BASIC EDUCATIONAL REQUIREMENTS FOR THE ARCHITECTURAL PLANNING OF THE CAMPUS. CONSIDERATION WAS GIVEN TO SITE PLANNING AND DEVELOPMENT AND TO FACILITIES FOR ADMINISTRATION, STUDENT PERSONNEL…

Automation and robotics considerations for a lunar base

NASA Technical Reports Server (NTRS)

Sliwa, Nancy E.; Harrison, F. Wallace, Jr.; Soloway, Donald I.; Mckinney, William S., Jr.; Cornils, Karin; Doggett, William R.; Cooper, Eric G.; Alberts, Thomas E.

1992-01-01

An envisioned lunar outpost shares with other NASA missions many of the same criteria that have prompted the development of intelligent automation techniques with NASA. Because of increased radiation hazards, crew surface activities will probably be even more restricted than current extravehicular activity in low Earth orbit. Crew availability for routine and repetitive tasks will be at least as limited as that envisioned for the space station, particularly in the early phases of lunar development. Certain tasks are better suited to the untiring watchfulness of computers, such as the monitoring and diagnosis of multiple complex systems, and the perception and analysis of slowly developing faults in such systems. In addition, mounting costs and constrained budgets require that human resource requirements for ground control be minimized. This paper provides a glimpse of certain lunar base tasks as seen through the lens of automation and robotic (A&R) considerations. This can allow a more efficient focusing of research and development not only in A&R, but also in those technologies that will depend on A&R in the lunar environment.

Preliminary design polymeric materials experiment. [for space shuttles and Spacelab missions

NASA Technical Reports Server (NTRS)

Mattingly, S. G.; Rude, E. T.; Marshner, R. L.

1975-01-01

A typical Advanced Technology Laboratory mission flight plan was developed and used as a guideline for the identification of a number of experiment considerations. The experiment logistics beginning with sample preparation and ending with sample analysis are then overlaid on the mission in order to have a complete picture of the design requirements. The results of this preliminary design study fall into two categories. First specific preliminary designs of experiment hardware which is adaptable to a variety of mission requirements. Second, identification of those mission considerations which affect hardware design and will require further definition prior to final design. Finally, a program plan is presented which will provide the necessary experiment hardware in a realistic time period to match the planned shuttle flights. A bibliography of all material reviewed and consulted but not specifically referenced is provided.

Development of vendor evaluation criteria and post-implementation considerations for MSFC center-wide executive information system

NASA Technical Reports Server (NTRS)

Moynihan, Gary P.

1992-01-01

In June 1991, the MITRE Corporation submitted a series of recommendations as part of a Marshall Space Flight Center (MSFC) Management Information System Requirements Study, initiated by the Information Systems Office (ISO). A major recommendation of the study was to develop an Executive Information System (EIS) for MSFC executives. ISO was directed, by center management, to proceed with the development of a Center-Wide Executive Information System. Existing EIS prototypes, developed by the Space Shuttle Projects Office and the Payload Projects Office, were reviewed. These existing MSFC prototypes were considered not to encompass the required functionality needed on a center-wide basis. A follow-up study by MITRE provided top-level system requirements. These were later incorporated into a final requirements specification document by Boeing Computer Support Services.

Creating a learning organization to help meet the needs of multihospital health systems.

PubMed

Ward, Angela; Berensen, Nannette; Daniels, Rowell

2018-04-01

The considerations that leaders of multihospital health systems must take into account in developing and implementing initiatives to build and maintain an exceptional pharmacy workforce are described. Significant changes that require constant individual and organizational learning are occurring throughout healthcare and within the profession of pharmacy. These considerations include understanding why it is important to have a succession plan and determining what types of education and training are important to support that plan. Other considerations include strategies for leveraging learners, dealing with a large geographic footprint, adjusting training opportunities to accommodate the ever-evolving demands on pharmacy staffs in terms of skill mix, and determining ways to either budget for or internally develop content for staff development. All of these methods are critically important to ensuring an optimized workforce. Especially for large health systems operating multiple sites across large distances, the use of technology-enabled solutions to provide effective delivery of programming to multiple sites is critical. Commonly used tools include live webinars, live "telepresence" programs, prerecorded programming that is available through an on-demand repository, and computer-based training modules. A learning management system is helpful to assign and document completion of educational requirements, especially those related to regulatory requirements (e.g., controlled substances management, sterile and nonsterile compounding, competency assessment). Creating and sustaining an environment where all pharmacy caregivers feel invested in and connected to ongoing learning is a powerful motivator for performance, engagement, and retention. Copyright © 2018 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

7 CFR 3570.70 - Other considerations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... suspension (nonprocurement) and requirements for drug-free workplace are applicable to CFG and grantees. See... CFR part 3018. (d) Civil Rights Impact Analysis, RD Instruction 2006-P (available in any Rural Development office), and “Civil Rights Impact Analysis Certification.” ...

Design considerations for bridge deck joint-sealing systems : summary report.

DOT National Transportation Integrated Search

1992-07-01

This is a report summary which summarizes a three year research effort related to the study of bridge deck expansion joint movements. Bridge deck expansion joint systems often develop serious problems requiring extensive and expensive maintenance. Th...

Considerations Regarding the Development of an Environmental Control and Life Support System for Lunar Surface Applications

NASA Technical Reports Server (NTRS)

Bagdigian, Robert M.

2008-01-01

NASA is engaged in early architectural analyses and trade studies aimed at identifying requirements, predicting performance and resource needs, characterizing mission constraints and sensitivities, and guiding technology development planning needed to conduct a successful human exploration campaign of the lunar surface. Conceptual designs and resource estimates for environmental control and life support systems (ECLSS) within pressurized lunar surface habitats and rovers have been considered and compared in order to support these lunar campaign studies. This paper will summarize those concepts and some of the more noteworthy considerations that will likely remain as key drivers in the evolution of the lunar surface ECLSS architecture.

AGT 100 automotive gas turbine system development

NASA Technical Reports Server (NTRS)

Helms, H. E. G.

1982-01-01

General Motors is developing an automotive gas turbine system that can be an alternate powerplant for future automobiles. Work sponsored by DOE and administered by NASA Lewis Research Center is emphasizing small component aerodynamics and high-temperature structural ceramics. Reliability requirements of the AGT 100 turbine system include chemical and structural ceramic component stability in the gas turbine environment. The power train system, its configuration and schedule are presented, and its performance tested. The aerodynamic component development is reviewed with discussions on the compressor, turbine, regenerator, interturbine duct and scroll, and combustor. Ceramic component development is also reviewed, and production cost and required capital investment are taken into consideration.

Design of the software development and verification system (SWDVS) for shuttle NASA study task 35

NASA Technical Reports Server (NTRS)

Drane, L. W.; Mccoy, B. J.; Silver, L. W.

1973-01-01

An overview of the Software Development and Verification System (SWDVS) for the space shuttle is presented. The design considerations, goals, assumptions, and major features of the design are examined. A scenario that shows three persons involved in flight software development using the SWDVS in response to a program change request is developed. The SWDVS is described from the standpoint of different groups of people with different responsibilities in the shuttle program to show the functional requirements that influenced the SWDVS design. The software elements of the SWDVS that satisfy the requirements of the different groups are identified.

Historical trend in the research and development of aircraft

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1981-01-01

Results are presented from a study of aircraft design trends undertaken to determine the relationship between research, development, test and evaluation and aircraft mission capability, requirements and objectives. It is shown that while in some cases a performance objective was the primary research driver, research was the driver in the formulation of objectives in others. Among the topics discussed are: (1) speed considerations such as compressibility, propulsion and test techniques; (2) airframe considerations such as swept, delta, trapezoidal and variable-sweep planforms and mission commonality; (3) research aircraft; (4) the recent impact of computer-aided design; (5) Soviet aircraft development approaches and (6) a comparison of Soviet and U.S. military aircraft design trends. Attention is given to experimental and prototype aircraft programs which, although cancelled, anticipated significant subsequent developments.

Crew considerations in the design for Space Station Freedom modules on-orbit maintenance

NASA Technical Reports Server (NTRS)

Stokes, Jack W.; Williams, Katherine A.

1992-01-01

The paper presents an approach to the maintenance process currently planned for the Space Station Freedom modules. In particular, it describes the planned crew interfaces with maintenance items, and the anticipated implications for the crew in performing the interior and exterior maintenance of modules developed by U.S., ESA, and NASDA. Special consideration is given to the maintenance requirements, allocations, and approach; the maintenance design; the Maintenance Workstation; the robotic mechanisms; and the developemnt of maintenance techniques.

Considerations in the use of models available for fuel treatment analysis

Treesearch

Charles W. McHugh

2006-01-01

Fire managers are required to evaluate and justify the effectiveness of planned fuel treatments in modifying fire growth, behavior and effects on resources and assets. With the number of models currently available, today’s fire manager can become overwhelmed when deciding which model to use. Each model has a required level of expertise in order to develop the necessary...

Linking Development Benefits to Neighborhoods: A Manual of Community-Based Strategies. Technical Bulletin.

ERIC Educational Resources Information Center

Casale, Ellen

This manual collects experiences of successful linkage programs to demonstrate the promise of linkage and to show its limits and risks. It is intended to help communities assess the capacity of linkage to meet their needs and evaluate the considerable commitment this strategy requires. (In linkage programs, developers who receive community…

Integrating Anatomy Training into Radiation Oncology Residency: Considerations for Developing a Multidisciplinary, Interactive Learning Module for Adult Learners

ERIC Educational Resources Information Center

Labranche, Leah; Johnson, Marjorie; Palma, David; D'Souza, Leah; Jaswal, Jasbir

2015-01-01

Radiation oncologists require an in-depth understanding of anatomical relationships for modern clinical practice, although most do not receive formal anatomy training during residency. To fulfill the need for instruction in relevant anatomy, a series of four multidisciplinary, interactive learning modules were developed for a cohort of radiation…

Planetary mission requirements, technology and design considerations for a solar electric propulsion stage

NASA Technical Reports Server (NTRS)

Cork, M. J.; Hastrup, R. C.; Menard, W. A.; Olson, R. N.

1979-01-01

High energy planetary missions such as comet rendezvous, Saturn orbiter and asteroid rendezvous require development of a Solar Electric Propulsion Stage (SEPS) for augmentation of the Shuttle-IUS. Performance and functional requirements placed on the SEPS are presented. These requirements will be used in evolution of the SEPS design, which must be highly interactive with both the spacecraft and the mission design. Previous design studies have identified critical SEPS technology areas and some specific design solutions which are also presented in the paper.

Defining Operational Space Suit Requirements for Commercial Orbital Spaceflight

NASA Technical Reports Server (NTRS)

Alpert, Brian K.

2015-01-01

As the commercial spaceflight industry transitions from suborbital brevity to orbital outposts, spacewalking will become a major consideration for tourists, scientists, and hardware providers. The challenge exists to develop a space suit designed for the orbital commercial spaceflight industry. The unique needs and requirements of this industry will drive space suit designs and costs that are unlike any existing product. Commercial space tourists will pay for the experience of a lifetime, while scientists may not be able to rely on robotics for all operations and external hardware repairs. This study was aimed at defining space suit operational and functional needs across the spectrum of spacewalk elements, identifying technical design drivers and establishing appropriate options. Recommendations from the analysis are offered for consideration

Multiple fracturing experiments: propellant and borehole considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuderman, J F

1982-01-01

The technology for multiple fracturing of a wellbore, using progressively burning propellants, is being developed to enhance natural gas recovery. Multiple fracturing appears especially attractive for stimulating naturally fractured reservoirs such as Devonian shales where it is expected to effectively intersect existing fractures and connect them to a wellbore. Previous experiments and modeling efforts defined pressure risetimes required for multiple fracturing as a function of borehole diameter, but identified only a weak dependence on peak pressure attained. Typically, from four to eight equally spaced major fractures occur as a function of pressure risetime and in situ stress orientation. The presentmore » experiments address propellant and rock response considerations required to achieve the desired pressure risetimes for reliable multiple fracturing.« less

First Crewed Flight: Rationale, Considerations and Challenges from the Constellation Experience

NASA Technical Reports Server (NTRS)

Noriega, Carlos; Arceneaux, William; Williams, Jeffrey A.; Rhatigan, Jennifer L.

2011-01-01

NASA's Constellation Program has made the most progress in a generation towards building an integrated human-rated spacecraft and launch vehicle. During that development, it became clear that NASA's human-rating requirements lacked the specificity necessary to defend a program plan, particularly human-rating test flight plans, from severe budget challenges. This paper addresses the progress Constellation achieved, problems encountered in clarifying and defending a human-rating certification plan, and discusses key considerations for those who find themselves in similar straits with future human-rated spacecraft and vehicles. We assert, and support with space flight data, that NASA's current human-rating requirements do not adequately address "unknown-unknowns", or the unexpected things the hardware can reveal to the designer during test.

Evaluating the Veterans Health Administration's Staffing Methodology Model: A Reliable Approach.

PubMed

Taylor, Beth; Yankey, Nicholas; Robinson, Claire; Annis, Ann; Haddock, Kathleen S; Alt-White, Anna; Krein, Sarah L; Sales, Anne

2015-01-01

All Veterans Health Administration facilities have been mandated to use a standardized method of determining appropriate direct-care staffing by nursing personnel. A multi-step process was designed to lead to projection of full-time equivalent employees required for safe and effective care across all inpatient units. These projections were intended to develop appropriate budgets for each facility. While staffing levels can be increased, even in facilities subject to budget and personnel caps, doing so requires considerable commitment at all levels of the facility. This commitment must come from front-line nursing personnel to senior leadership, not only in nursing and patient care services, but throughout the hospital. Learning to interpret and rely on data requires a considerable shift in thinking for many facilities, which have relied on historical levels to budget for staffing, but which does not take into account the dynamic character of nursing units and patient need.

Orbital transportation in the 1980's and beyond

NASA Technical Reports Server (NTRS)

Davis, H. P.

1975-01-01

Orbital transportation beyond the low earth orbit operating regime of the Space Shuttle will be required for the 1980's and beyond. The characteristics and first order requirements of the mission arenas are discussed in context with a broad spectrum of future space transportation systems. Several concepts are highlighted and identify the distinctly different requirements imposed by manned vehicles versus unmanned vehicles. Considerable analytic and design activities are necessary prior to selection of orbital transportation systems to be developed after the Interim Upper Stage (IUS).

Successful development of recombinant DNA-derived pharmaceuticals.

PubMed

Werner, R G; Pommer, C H

1990-11-01

Successful development of recombinant DNA-derived pharmaceuticals, a new class of therapeutic agents, is determined by a variety of factors affecting the selection and positioning of the compound under development. For an efficient development it is of utmost importance that the mechanism of action of the compound selected be understood on a molecular level. The compound's potential therapeutical profile and a strong patent position are key positioning considerations, as well as vital elements in shortening the development phase and protecting innovation. Installation of an interdisciplinary project management team, along with a clear definition of team members' responsibilities, is required to avoid delays and improve communication during development. Selection of the organism to be used in production must take into consideration both the structure of the protein and the quality and safety of the final product. New technologies require a considerable investment in new manufacturing facilities and equipment. Often, the decision for such an investment must be made early and with a high degree of uncertainty. Desired product yield, expected dosage, and estimated market potential are the most important considerations in this decision. Following public disclosure of the plan to develop recombinant DNA-derived products, approval of the production plant and expansion or adaptation to the new process and technology may be delayed. For this reason, they should be considered as a critical step in the overall development phase. Recruitment of qualified staff is a time-consuming and critical element of the production process. Its impact on the product timeline should not be underestimated, especially if such technologies are new to the company. The entire production process must be validated in respect to identity, purity, and safety of the product to guarantee constant product quality, as well as for safety aspects in the environment. Adequate in-process and final product controls have to be established and specifications determined for release or rejection of batches for preclinical and clinical studies as well as for marketing. Preclinical testing is limited because recombinant DNA-derived proteins cannot be differentiated from naturally occurring human proteins, and because some proteins are species-specific.

Some process control/design considerations in the development of a microgravity mammalian cell bioreactor

NASA Technical Reports Server (NTRS)

Goochee, Charles F.

1987-01-01

The purpose is to review some of the physical/metabolic factors which must be considered in the development of an operating strategy for a mammalian cell bioreactor. Emphasis is placed on the dissolved oxygen and carbon dioxide requirements of growing mammalian epithelial cells. Literature reviews concerning oxygen and carbon dioxide requirements are discussed. A preliminary, dynamic model which encompasses the current features of the NASA bioreactor is presented. The implications of the literature survey and modeling effort on the design and operation of the NASA bioreactor are discussed.

Optical System Design for the Next Generation Space Telescope

NASA Technical Reports Server (NTRS)

Solomon, Leonard H. (Principal Investigator); Kahan, Mark A.

1996-01-01

This report provides considerations and suggested approaches for design of the Optical Telescope Assembly and the segmented primary mirror of a Next Generation Space Telescope (NGST). Based on prior studies and hardware development, we provide data and design information on low-risk materials and hardware configurations most likely to meet low weight, low temperature and long-life requirements of the nominal 8-meter aperture NGST. We also provide preliminary data for cost and performance trades, and recommendations for technology development and demonstration required to support the system design effort.

Consideration of health inequalities in systematic reviews: a mapping review of guidance.

PubMed

Maden, Michelle

2016-11-28

Given that we know that interventions shown to be effective in improving the health of a population may actually widen the health inequalities gap while others reduce it, it is imperative that all systematic reviewers consider how the findings of their reviews may impact (reduce or increase) on the health inequality gap. This study reviewed existing guidance on incorporating considerations of health inequalities in systematic reviews in order to examine the extent to which they can help reviewers to incorporate such issues. A mapping review was undertaken to identify guidance documents that purported to inform reviewers on whether and how to incorporate considerations of health inequalities. Searches were undertaken in Medline, CINAHL and The Cochrane Library Methodology Register. Review guidance manuals prepared by international organisations engaged in undertaking systematic reviews, and their associated websites were scanned. Studies were included if they provided an overview or discussed the development and testing of guidance for dealing with the incorporation of considerations of health inequalities in evidence synthesis. Results are summarised in narrative and tabular forms. Twenty guidance documents published between 2009 and 2016 were included. Guidance has been produced to inform considerations of health inequalities at different stages of the systematic review process. The Campbell and Cochrane Equity Group have been instrumental in developing and promoting such guidance. Definitions of health inequalities and guidance differed across the included studies. All but one guidance document were transparent in their method of production. Formal methods of evaluation were reported for six guidance documents. Most of the guidance was operationalised in the form of examples taken from published systematic reviews. The number of guidance items to operationalise ranges from 3 up to 26 with a considerable overlap noted. Adhering to the guidance will require more work for the reviewers. It requires a deeper understanding of how reviewers can operationalise the guidance taking into consideration the barriers and facilitators involved. This has implications not only for understanding the usefulness and burden of the guidance but also for the uptake of guidance and its ultimate goal of improving health inequalities considerations in systematic reviews.

Parrallel power for undersea application: The basic considerations

NASA Technical Reports Server (NTRS)

Kirkham, H.; Howe, B.

2001-01-01

Power systems for undersea observatories are required to deliver high power with good reliability. For the proposed NEPTUNE observatory, the authors have developed a power scheme that combines ideas from terrestial power systems and switching power supplies with experience from undersea cable systems.

48 CFR 11.103 - Market acceptance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... supported by market research; (4) Include consideration of items supplied satisfactorily under recent or... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Market acceptance. 11.103... DESCRIBING AGENCY NEEDS Selecting and Developing Requirements Documents 11.103 Market acceptance. (a) Section...

48 CFR 11.103 - Market acceptance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... supported by market research; (4) Include consideration of items supplied satisfactorily under recent or... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Market acceptance. 11.103... DESCRIBING AGENCY NEEDS Selecting and Developing Requirements Documents 11.103 Market acceptance. (a) Section...

Cost as a Military Requirement

DTIC Science & Technology

2013-01-01

from http://www.forbes.com/sites/frederickallen/2011/08/02/there-are- three-kinds-of-innovation- dont -get-trapped-doing-the-wrong-one/ Arena, M...Consideration of the CONOPS as part of the system development tradespace. Poster presentation at the National Defense Industrial Association (NDIA

Considerations for the Next Revision of STRS

NASA Technical Reports Server (NTRS)

Johnson, Sandra K.; Handler, Louis M.; Briones, Janette C.

2016-01-01

Development of NASAs Software Defined Radio architecture, the Space Telecommunication Radio System (STRS), was initiated in 2004 with a goal of reducing the cost, risk and schedule when implementing Software Defined Radios (SDR) for NASA space missions. Since STRS was first flown in 2012 on three Software Defined Radios on the Space Communication and Navigation (SCaN) Testbed, only minor changes have been made to the architecture. Multiple entities have since implemented the architecture and have provided significant feedback for consideration for the next revision of the standard. The focus for the first set of updates to the architecture is items that enhance application portability. Items that require modifications to existing applications before migrating to the updated architecture will only be considered if there is compelling reasons to make the change. The significant suggestions that were further evaluated for consideration include expanding and clarifying the timing Application Programming Interfaces (APIs), improving handle name and identification (ID) definitions and use, and multiple items related to implementation of STRS Devices. In addition to ideas suggested while implementing STRS, SDR technology has evolved significantly and this impact to the architecture needs to be considered. These include incorporating cognitive concepts - learning from past decisions and making new decisions that the radio can act upon. SDRs are also being developed that do not contain a General Purpose Module which is currently required for the platform to be STRS compliant. The purpose of this paper is to discuss the comments received, provide a summary of the evaluation considerations, and examine planned dispositions

A framework for the design and development of physical employment tests and standards.

PubMed

Payne, W; Harvey, J

2010-07-01

Because operational tasks in the uniformed services (military, police, fire and emergency services) are physically demanding and incur the risk of injury, employment policy in these services is usually competency based and predicated on objective physical employment standards (PESs) based on physical employment tests (PETs). In this paper, a comprehensive framework for the design of PETs and PESs is presented. Three broad approaches to physical employment testing are described and compared: generic predictive testing; task-related predictive testing; task simulation testing. Techniques for the selection of a set of tests with good coverage of job requirements, including job task analysis, physical demands analysis and correlation analysis, are discussed. Regarding individual PETs, theoretical considerations including measurability, discriminating power, reliability and validity, and practical considerations, including development of protocols, resource requirements, administrative issues and safety, are considered. With regard to the setting of PESs, criterion referencing and norm referencing are discussed. STATEMENT OF RELEVANCE: This paper presents an integrated and coherent framework for the development of PESs and hence provides a much needed theoretically based but practically oriented guide for organisations seeking to establish valid and defensible PESs.

48 CFR 29.304 - Matters requiring special consideration.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Matters requiring special consideration. 29.304 Section 29.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES State and Local Taxes 29.304 Matters requiring special...

48 CFR 29.304 - Matters requiring special consideration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Matters requiring special consideration. 29.304 Section 29.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES State and Local Taxes 29.304 Matters requiring special...

48 CFR 29.304 - Matters requiring special consideration.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Matters requiring special consideration. 29.304 Section 29.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES State and Local Taxes 29.304 Matters requiring special...

48 CFR 29.304 - Matters requiring special consideration.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Matters requiring special consideration. 29.304 Section 29.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES State and Local Taxes 29.304 Matters requiring special...

48 CFR 29.304 - Matters requiring special consideration.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Matters requiring special consideration. 29.304 Section 29.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES State and Local Taxes 29.304 Matters requiring special...

Earth Observatory Satellite system definition study. Report no. 4: Management approach recommendations

NASA Technical Reports Server (NTRS)

1974-01-01

A management approach for the Earth Observatory Satellite (EOS) which will meet the challenge of a constrained cost environment is presented. Areas of consideration are contracting techniques, test philosophy, reliability and quality assurance requirements, commonality options, and documentation and control requirements. The various functional areas which were examined for cost reduction possibilities are identified. The recommended management approach is developed to show the primary and alternative methods.

Succession planning and leadership development: critical business strategies for healthcare organizations.

PubMed

Collins, Sandra K; Collins, Kevin S

2007-01-01

As labor shortages intensify, succession planning and leadership development have become strategic initiatives requiring rigorous consideration. Traditional methods of replacing personnel will not accommodate the vacancies expected to plague healthcare organizations. Managers should focus on identifying potential gaps of key personnel and adapting programs to accommodate organizational need. Attention should be placed on capturing the intellectual capital existent in the organization and developing diverse groups of leadership candidates.

Mission Peculiar Equipment (MPE) For Spacelab Mission 1 Payload

NASA Astrophysics Data System (ADS)

Sims, John H.; Dodeck, Hauke

1982-02-01

Spacelab interfaces and services for payloads are advertised in the Spacelab Payload Accommodations Handbook (SPAH). These accommodations are available to the total payload and must be managed and apportioned by a payload integrator. A major part of the integration task is satisfying all instruments/facilities servicing requirements which vary with each item of payload equipment and, when totalled, sometimes exceed the capabilities as defined in SPAH. Such a determination is an output of the integrated payload design and integration effort which consists of analytical assessments based on individual payload equipment requirements inputs, STS and Spacelab available accommodations and constraints, and programmatic considerations. This systems engineering activity spans all engineering disciplines, assesses the module and pallet layouts and simultaneous operation of instrument/facility combinations, and requires a detailed knowledge of the Spacelab design. Introduction of a broad range of payload integrator-provided Mission Peculiar Equipment (MPE) into the Spacelab Mission 1 payload complement was necessary to be added to the Spacelab provisions in order to satisfy the interface and service requirements for each payload developer. This paper provides insight into various aspects of this MPE; including why it is needed, driving design considerations, design and development problems, and conclusions and recommendations for the future. MPE identified for Spacelab Mission 1 begins an inventory that will continue to expand as other mission requirements are identified and the Spacelab flight frequency increases.

Engaging Teacher Educators with the Sustainability Agenda: A Case Study of a Pilot Professional Development Program from Ethiopia

ERIC Educational Resources Information Center

Amado, Addise; Dalelo, Aklilu; Adomßent, Maik; Fischer, Daniel

2017-01-01

Purpose: There is broad consensus that the implementation of education for sustainable development (ESD) requires the consideration of geographical and cultural contexts. Despite such an agreement at a theoretical level, there is so far an apparent lack of practical experiences and solid research on approaches that effectively manage to engage…

Persuasive Writing in Children, Adolescents, and Adults: A Study of Syntactic, Semantic, and Pragmatic Development

ERIC Educational Resources Information Center

Nippold, Marilyn A.; Ward-Lonergan, Jeannene M.; Fanning, Jessica L.

2005-01-01

Purpose: Persuasive writing is a demanding task that requires the use of complex language to analyze, discuss, and resolve controversies in a way that is clear, convincing, and considerate of diverse points of view. This investigation examined selected aspects of later language development in the context of persuasive writing. The purpose of the…

Brownian movement and microscopic irreversibility

NASA Astrophysics Data System (ADS)

Gordon, L. G. M.

1981-02-01

An extension of the hypothetical experiment of Szilard, which involved the action of a one-molecule gas in an isolated isothermal system, is developed to illustrate how irreversibility may arise out of Brownian motion. As this development requires a consideration of nonmolecular components such as wheels and pistons, the thought-experiment is remodeled in molecular terms and appears to function as a perpetuum mobile.

Career Development and Promotion in an Academic Health Center.

PubMed

Christophersen, Edward R

2017-03-01

This paper examines the successive stages of the career path for psychologists who commit to spending their professional lives working in academic health centers. Key factors for success at each stage are described, as are the steps required for progressing to subsequent stages of professional development. The paper breaks new ground by including consideration of a post-retirement stage, "Professor Emeritus status."

Assessing land-use impacts on biodiversity using an expert systems tool

USGS Publications Warehouse

Crist, P.J.; Kohley, T.W.; Oakleaf, J.

2000-01-01

Habitat alteration, in the form of land-use development, is a leading cause of biodiversity loss in the U.S. and elsewhere. Although statutes in the U.S. may require consideration of biodiversity in local land-use planning and regulation, local governments lack the data, resources, and expertise to routinely consider biotic impacts that result from permitted land uses. We hypothesized that decision support systems could aid solution of this problem. We developed a pilot biodiversity expert systems tool (BEST) to test that hypothesis and learn what additional scientific and technological advancements are required for broad implementation of such a system. BEST uses data from the U.S. Geological Survey's Gap Analysis Program (GAP) and other data in a desktop GIS environment. The system provides predictions of conflict between proposed land uses and biotic elements and is intended for use at the start of the development review process. Key challenges were the development of categorization systems that relate named land-use types to ecological impacts, and relate sensitivities of biota to ecological impact levels. Although the advent of GAP and sophisticated desktop GIS make such a system feasible for broad implementation, considerable ongoing research is required to make the results of such a system scientifically sound, informative, and reliable for the regulatory process. We define a role for local government involvement in biodiversity impact assessment, the need for a biodiversity decision support system, the development of a prototype system, and scientific needs for broad implementation of a robust and reliable system.

Perspectives on Introduction and Implementation of New Point-of-Care Diagnostic Tests

PubMed Central

Palamountain, Kara M.; Baker, Jeff; Cowan, Elliot P.; Essajee, Shaffiq; Mazzola, Laura T.; Metzler, Mutsumi; Schito, Marco; Stevens, Wendy S.; Young, Gloria J.

2012-01-01

In recent years, there has been significant investment from both the private and public sectors in the development of diagnostic technologies to meet the need for human immunodeficiency virus (HIV) and tuberculosis testing in low-resource settings. Future investments should ensure that the most appropriate technologies are adopted in settings where they will have a sustainable impact. Achieving these aims requires the involvement of many stakeholders, as their needs, operational constraints, and priorities are often distinct. Here, we discuss these considerations from different perspectives representing those of various stakeholders involved in the development, introduction, and implementation of diagnostic tests. We also discuss some opportunities to address these considerations. PMID:22402038

Twelve tips for getting started using mixed methods in medical education research.

PubMed

Lavelle, Ellen; Vuk, Jasna; Barber, Carolyn

2013-04-01

Mixed methods research, which is gaining popularity in medical education, provides a new and comprehensive approach for addressing teaching, learning, and evaluation issues in the field. The aim of this article is to provide medical education researchers with 12 tips, based on consideration of current literature in the health professions and in educational research, for conducting and disseminating mixed methods research. Engaging in mixed methods research requires consideration of several major components: the mixed methods paradigm, types of problems, mixed method designs, collaboration, and developing or extending theory. Mixed methods is an ideal tool for addressing a full range of problems in medical education to include development of theory and improving practice.

Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium.

PubMed

Baxendale, Ian R; Braatz, Richard D; Hodnett, Benjamin K; Jensen, Klavs F; Johnson, Martin D; Sharratt, Paul; Sherlock, Jon-Paul; Florence, Alastair J

2015-03-01

This whitepaper highlights current challenges and opportunities associated with continuous synthesis, workup, and crystallization of active pharmaceutical ingredients (drug substances). We describe the technologies and requirements at each stage and emphasize the different considerations for developing continuous processes compared with batch. In addition to the specific sequence of operations required to deliver the necessary chemical and physical transformations for continuous drug substance manufacture, consideration is also given to how adoption of continuous technologies may impact different manufacturing stages in development from discovery, process development, through scale-up and into full scale production. The impact of continuous manufacture on drug substance quality and the associated challenges for control and for process safety are also emphasized. In addition to the technology and operational considerations necessary for the adoption of continuous manufacturing (CM), this whitepaper also addresses the cultural, as well as skills and training, challenges that will need to be met by support from organizations in order to accommodate the new work flows. Specific action items for industry leaders are: Develop flow chemistry toolboxes, exploiting the advantages of flow processing and including highly selective chemistries that allow use of simple and effective continuous workup technologies. Availability of modular or plug and play type equipment especially for workup to assist in straightforward deployment in the laboratory. As with learning from other industries, standardization is highly desirable and will require cooperation across industry and academia to develop and implement. Implement and exploit process analytical technologies (PAT) for real-time dynamic control of continuous processes. Develop modeling and simulation techniques to support continuous process development and control. Progress is required in multiphase systems such as crystallization. Involve all parts of the organization from discovery, research and development, and manufacturing in the implementation of CM. Engage with academia to develop the training provision to support the skills base for CM, particularly in flow chemistry, physical chemistry, and chemical engineering skills at the chemistry-process interface. Promote and encourage publication and dissemination of examples of CM across the sector to demonstrate capability, engage with regulatory comment, and establish benchmarks for performance and highlight challenges. Develop the economic case for CM of drug substance. This will involve various stakeholders at project and business level, however establishing the critical economic drivers is critical to driving the transformation in manufacturing. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

32 CFR Enclosure 1 - Requirements for Environmental Considerations-Global Commons

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Requirements for Environmental Considerations... ENVIRONMENT ENVIRONMENTAL EFFECTS ABROAD OF MAJOR DEPARTMENT OF DEFENSE ACTIONS Information requirements. Pt. 187, Encl. 1 Enclosure 1—Requirements for Environmental Considerations—Global Commons A. General. This...

32 CFR Enclosure 1 - Requirements for Environmental Considerations-Global Commons

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Requirements for Environmental Considerations... ENVIRONMENT ENVIRONMENTAL EFFECTS ABROAD OF MAJOR DEPARTMENT OF DEFENSE ACTIONS Information requirements. Pt. 187, Encl. 1 Enclosure 1—Requirements for Environmental Considerations—Global Commons A. General. This...

Developing hydropower in Washington state. Volume 2: An electricity marketing manual

NASA Astrophysics Data System (ADS)

James, J. W.; McCoy, G. A.

1982-03-01

An electricity marketing manual for the potential small and micro-hydroelectric project developer within the state of Washington is presented. Public utility regulatory policies (PURPA) requires electric utilities to interconnect with and pay a rate based on their full avoided costs for the purchase of electrical output from qualifying small power production facilities. The determination of avoided costs, as business organizational considerations, utility interface concerns, interconnection requirements, metering options, and liability and wheeling are discussed. The utility responses are summarized, legislation which is of importance to hydropower developers and the powers and functions of the authorities responsible for enforcing the mandate of PURPA are described.

Engineering department physical plant staffing requirements.

PubMed

Cole, C

1997-05-01

There is a considerable effort in the health care arena to establish credible engineering manpower yardsticks that are universally applicable as a benchmark. This document was created by using one facility's own benchmark criteria that can be used to help develop either internal or competitive benchmarking comparisons.

Training Materials Developed for Latino Entrepreneurs

ERIC Educational Resources Information Center

Abreo, Christina; Miller, Wayne; Farmer, Frank; Moon, Zola; McCullough, Stacey

2014-01-01

This article describes the materials and training program that Extension created to assist current and potential Latino immigrant entrepreneurs in starting businesses in Arkansas. The content-based educational materials describe the process for starting a new business, government regulatory requirements, start-up costs and considerations, and how…

Instructional Coaching Implementation: Considerations for K-12 Administrators

ERIC Educational Resources Information Center

Johnson, Kelly Gomez

2016-01-01

Instructional coaching is a reality in many schools today, yet administrators often lack experience or background on how to utilize this professional development model effectively. Instructional coaching can help administrators balance the managerial and instructional leadership responsibilities required of their role. As districts adopt the…

Thermodynamic considerations in the support of life for long space voyages

NASA Technical Reports Server (NTRS)

Iberall, A. S.; Cardon, S. Z.

1979-01-01

The essential requirements for the maintenance of life, particularly human life, on isolated space missions of long duration were investigated through the study of extended irreversible thermodynamics. The characterization of a four trophic level system was developed. Questions of stability are discussed.

48 CFR 733.103-71 - Filing of protest.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-71 Section 733.103-71 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Protests 733.103-71 Filing of protest. (a) Protests must be in writing and addressed to the Contracting Officer for consideration by the M/OAA...

48 CFR 733.103-71 - Filing of protest.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-71 Section 733.103-71 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Protests 733.103-71 Filing of protest. (a) Protests must be in writing and addressed to the Contracting Officer for consideration by the M/OAA...

REVIEW OF CONTROL OPTIONS FOR METHYL BROMIDE IN COMMODITY TREATMENT

EPA Science Inventory

The report describes recent developments in the control of methyl bromide (MeBr) and discusses technical considerations and requirements for and economic feasibility of recovery. (NOTE: MeBr, fumigant for agricultural commodities, is an ozone depleting chemical. The U.S. EPA has ...

Centrifugal pumps for rocket engines

NASA Technical Reports Server (NTRS)

Campbell, W. E.; Farquhar, J.

1974-01-01

The use of centrifugal pumps for rocket engines is described in terms of general requirements of operational and planned systems. Hydrodynamic and mechanical design considerations and techniques and test procedures are summarized. Some of the pump development experiences, in terms of both problems and solutions, are highlighted.

A Framework for Integrating Biosimilars Into the Didactic Core Requirements of a Doctor of Pharmacy Curriculum.

PubMed

Li, Edward; Liu, Jennifer; Ramchandani, Monica

2017-04-01

Biologic drugs approved via the abbreviated United States biosimilar approval pathway are anticipated to improve access to medications by addressing increasing health care expenditures. Surveys of health care practitioners indicate that there is inadequate knowledge and understanding about biosimilars; this must be addressed to ensure safe and effective use of this new category of products. Concepts of biosimilar development, manufacturing, regulation, naming, formulary, and inventory considerations, as well as patient and provider education should be included within the doctor of pharmacy (PharmD) curriculum as preparation for clinical practice. Based on these considerations, we propose that PharmD graduates be required to have knowledge in the following domains regarding biologics and biosimilars: legal definition, development and regulation, state pharmacy practice laws, and pharmacy practice management. We link these general biosimilar concepts to the Accreditation Council for Pharmacy Education (ACPE) Standards 2016 and Center for the Advancement of Pharmacy Education (CAPE) Outcomes 2013, and provide example classroom learning objectives, in-class activities, and assessments to guide implementation.

Current Practices in Global/International Advanced Pharmacy Practice Experiences: Preceptor and Student Considerations.

PubMed

Dornblaser, Emily K; Ratka, Anna; Gleason, Shaun E; Ombengi, David N; Tofade, Toyin; Wigle, Patricia R; Zapantis, Antonia; Ryan, Melody; Connor, Sharon; Jonkman, Lauren J; Ochs, Leslie; Jungnickel, Paul W; Abrons, Jeanine P; Alsharif, Naser Z

2016-04-25

The objective of this article is to describe the key areas of consideration for global/international advanced pharmacy practice experience (G/I APPE) preceptors, students and learning objectives. At the 2013 Annual Meeting of the American Association of Colleges of Pharmacy (AACP), the GPE SIG prepared and presented an initial report on the G/IAPPE initiatives. Round table discussions were conducted at the 2014 AACP Annual Meeting to document GPE SIG member input on key areas in the report. Literature search of PubMed, Google Scholar and EMBASE with keywords was conducted to expand this report. In this paper, considerations related to preceptors and students and learning outcomes are described. Preceptors for G/I APPEs may vary based on the learning outcomes of the experience. Student learning outcomes for G/I APPEs may vary based on the type of experiential site. Recommendations and future directions for development of G/IAPPEs are presented. Development of a successful G/I APPE requires significant planning and consideration of appropriate qualifications for preceptors and students.

Using Physical Organic Chemistry To Shape the Course of Electrochemical Reactions.

PubMed

Moeller, Kevin D

2018-05-09

While organic electrochemistry can look quite different to a chemist not familiar with the technique, the reactions are at their core organic reactions. As such, they are developed and optimized using the same physical organic chemistry principles employed during the development of any other organic reaction. Certainly, the electron transfer that triggers the reactions can require a consideration of new "wrinkles" to those principles, but those considerations are typically minimal relative to the more traditional approaches needed to manipulate the pathways available to the reactive intermediates formed downstream of that electron transfer. In this review, three very different synthetic challenges-the generation and trapping of radical cations, the development of site-selective reactions on microelectrode arrays, and the optimization of current in a paired electrolysis-are used to illustrate this point.

Conceptual definition of a technology development mission for advanced solar dynamic power systems

NASA Technical Reports Server (NTRS)

Migra, R. P.

1986-01-01

An initial conceptual definition of a technology development mission for advanced solar dynamic power systems is provided, utilizing a space station to provide a dedicated test facility. The advanced power systems considered included Brayton, Stirling, and liquid metal Rankine systems operating in the temperature range of 1040 to 1400 K. The critical technologies for advanced systems were identified by reviewing the current state of the art of solar dynamic power systems. The experimental requirements were determined by planning a system test of a 20 kWe solar dynamic power system on the space station test facility. These requirements were documented via the Mission Requirements Working Group (MRWG) and Technology Development Advocacy Group (TDAG) forms. Various concepts or considerations of advanced concepts are discussed. A preliminary evolutionary plan for this technology development mission was prepared.

High Power LaB6 Plasma Source Performance for the Lockheed Martin Compact Fusion Reactor Experiment

NASA Astrophysics Data System (ADS)

Heinrich, Jonathon

2016-10-01

Lockheed Martin's Compact Fusion Reactor (CFR) concept is a linear encapsulated ring cusp. Due to the complex field geometry, plasma injection into the device requires careful consideration. A high power thermionic plasma source (>0.25MW; >10A/cm2) has been developed with consideration to phase space for optimal coupling. We present the performance of the plasma source, comparison with alternative plasma sources, and plasma coupling with the CFR field configuration. ©2016 Lockheed Martin Corporation. All Rights Reserved.

Aeroelastic simulation of higher harmonic control

NASA Technical Reports Server (NTRS)

Robinson, Lawson H.; Friedmann, Peretz P.

1994-01-01

This report describes the development of an aeroelastic analysis of a helicopter rotor and its application to the simulation of helicopter vibration reduction through higher harmonic control (HHC). An improved finite-state, time-domain model of unsteady aerodynamics is developed to capture high frequency aerodynamic effects. An improved trim procedure is implemented which accounts for flap, lead-lag, and torsional deformations of the blade. The effect of unsteady aerodynamics is studied and it is found that its impact on blade aeroelastic stability and low frequency response is small, but it has a significant influence on rotor hub vibrations. Several different HHC algorithms are implemented on a hingeless rotor and their effectiveness in reducing hub vibratory shears is compared. All the controllers are found to be quite effective, but very differing HHC inputs are required depending on the aerodynamic model used. Effects of HHC on rotor stability and power requirements are found to be quite small. Simulations of roughly equivalent articulated and hingeless rotors are carried out, and it is found that hingeless rotors can require considerably larger HHC inputs to reduce vibratory shears. This implies that the practical implementation of HHC on hingeless rotors might be considerably more difficult than on articulated rotors.

Recent advances in technologies required for a "Salad Machine".

PubMed

Kliss, M; Heyenga, A G; Hoehn, A; Stodieck, L S

2000-01-01

Future long duration, manned space flight missions will require life support systems that minimize resupply requirements and ultimately approach self-sufficiency in space. Bioregenerative life support systems are a promising approach, but they are far from mature. Early in the development of the NASA Controlled Ecological Life Support System Program, the idea of onboard cultivation of salad-type vegetables for crew consumption was proposed as a first step away from the total reliance on resupply for food in space. Since that time, significant advances in space-based plant growth hardware have occurred, and considerable flight experience has been gained. This paper revisits the "Salad Machine" concept and describes recent developments in subsystem technologies for both plant root and shoot environments that are directly relevant to the development of such a facility.

Recent Advances in Technologies Required for a ``Salad Machine''

NASA Astrophysics Data System (ADS)

Kliss, M.; Heyenga, A. G.; Hoehn, A.; Stodieck, L. S.

Future long duration, manned space flight missions will require life support systems that minimize resupply requirements and ultimately approach self-sufficiency in space. Bioregenerative life support systems are a promising approach, but they are far from mature. Early in the development of the NASA Controlled Ecological Life Support System Program, the idea of onboard cultivation of salad-type vegetables for crew consumption was proposed as a first step away from the total reliance on resupply for food in space. Since that time, significant advances in space-based plant growth hardware have occurred, and considerable flight experience has been gained. This paper revisits the ``Salad Machine'' concept and describes recent developments in subsystem technologies for both plant root and shoot environments that are directly relevant to the development of such a facility

32 CFR Enclosure 2 to Part 187 - Requirements for Environmental Considerations-Foreign Nations and Protected Global Resources

Code of Federal Regulations, 2014 CFR

2014-07-01

... evaluate requirements with respect to the environment; d. Ensure consideration of: (1) Requirements of... other similar broad-guage descriptive factors; b. Identification of the important environmental issues... in its internal affairs and its prerogative to evaluate requirements with respect to the environment...

32 CFR Enclosure 2 to Part 187 - Requirements for Environmental Considerations-Foreign Nations and Protected Global Resources

Code of Federal Regulations, 2013 CFR

2013-07-01

... evaluate requirements with respect to the environment; d. Ensure consideration of: (1) Requirements of... other similar broad-guage descriptive factors; b. Identification of the important environmental issues... in its internal affairs and its prerogative to evaluate requirements with respect to the environment...

Language (In)competency, Communication Strategies, and the Development of an International Academic Teacher Identity: Becoming an Audible Minority

ERIC Educational Resources Information Center

McAllum, Kirstie

2017-01-01

Despite universities' enthusiasm for internationalization, international academic mobility requires considerable institutional and cultural adjustment in terms of teaching and supervision styles, research expectations, and departmental relationships. Although language competency underpins these practices, research on international academics has…

Sitting in "Motion"

ERIC Educational Resources Information Center

Brinks, Kathrin

2009-01-01

For children, the urge to move is a basic need. Movement is essential for the development of physical and mental abilities. Quite often, for children with intellectual and physical disabilities who require special supportive seating, other considerations receive priority over movement in seats. The result is an even greater reduction of their…

Mission roles for the solar electric propulsion stage with the space transportation system

NASA Technical Reports Server (NTRS)

1974-01-01

A briefing outline is presented of the mission roles for the solar electric propulsion stage (SEPS). Topics outlined include operational considerations and mission characteristics, trade studies and technology assessments influencing SEPS configuration definition, program support requirements, and development and operations cost estimates.

Teachers' Emotions: An Illustrated Discussion.

ERIC Educational Resources Information Center

Golby, Michael

1996-01-01

Considers the situations of two women teachers who have profound commitments to their pupils and who gain considerable emotional security from this. Argues that they tend to define school matters outside of teaching as distractions. Suggests that professional development requires a whole-school approach with greater emotional commitment to…

Instream movements by boreal toads (Bufo boreas boreas)

Treesearch

Susan B. Adams; David A. Schmetterling; Michael K. Young

2005-01-01

Determining the nature and extent of bufonid movements is critical to understanding the autecology of each species, as well as to developing effective conservation strategies. Within many toad (Bufo spp.) populations, individuals must migrate considerable distances to reach habitats essential for fulfilling requirements that change seasonally and...

Gauge Impact with 5 Levels of Data

ERIC Educational Resources Information Center

Guskey, Thomas R.

2016-01-01

Effective professional learning evaluation requires consideration of five critical stages or levels of information. These five levels, which are presented in this article, represent an adaptation of an evaluation model developed by Kirkpatrick (1959, 1998) for judging the value of supervisory training programs in business and industry.…

Landscape values in public decisions

Treesearch

Richard N. L. Andrews

1979-01-01

The National Environmental Policy Act requires all agencies to develop techniques to insure appropriate consideration of all environmental amenities and values, including those presently unquantified, by all federal agencies in all their activities. These obviously include the values associated with the landscape and its visual resources. The visual resource, however,...

Economic considerations of breeding for polled dairy cows versus dehorning in the United States

USDA-ARS?s Scientific Manuscript database

Dairy producers today face labor, equipment, and medical costs associated with dehorning heifers. Further, complications requiring veterinary intervention occur with some probability. The objective of this work is to develop preliminary cost estimates of selecting for polled dairy heifers. Stochasti...

La Presse ecrite pas a pas (The Printed Media, Step by Step).

ERIC Educational Resources Information Center

Nott, David

1985-01-01

Argues that effective use of the print media in French instruction requires considerable preparation and participation on the teacher's part. A variety of exercises for thematic and lexical awareness, comprehension, guided production, autonomous production, simulation, grammar development, and other objectives are suggested. (MSE)

Littoral Combat Ship (LCS) Project: Consideration of an ASVAB Requirement for JOOD Screening

DTIC Science & Technology

2013-08-01

developed for the Submarine community. Sailors classified to the non-technical ratings of the Submarine Community ( Culinary Specialist, Storekeeper...ratings ( Culinary Specialist; Storekeeper; and Yeoman) and Seaman must meet the Submarine ASVAB “floor” standard in order to pass their submarine

The Essential Elements of a Risk Governance Framework for Current and Future Nanotechnologies.

PubMed

Stone, Vicki; Führ, Martin; Feindt, Peter H; Bouwmeester, Hans; Linkov, Igor; Sabella, Stefania; Murphy, Finbarr; Bizer, Kilian; Tran, Lang; Ågerstrand, Marlene; Fito, Carlos; Andersen, Torben; Anderson, Diana; Bergamaschi, Enrico; Cherrie, John W; Cowan, Sue; Dalemcourt, Jean-Francois; Faure, Michael; Gabbert, Silke; Gajewicz, Agnieszka; Fernandes, Teresa F; Hristozov, Danail; Johnston, Helinor J; Lansdown, Terry C; Linder, Stefan; Marvin, Hans J P; Mullins, Martin; Purnhagen, Kai; Puzyn, Tomasz; Sanchez Jimenez, Araceli; Scott-Fordsmand, Janeck J; Streftaris, George; van Tongeren, Martie; Voelcker, Nicolas H; Voyiatzis, George; Yannopoulos, Spyros N; Poortvliet, P Marijn

2017-12-14

Societies worldwide are investing considerable resources into the safe development and use of nanomaterials. Although each of these protective efforts is crucial for governing the risks of nanomaterials, they are insufficient in isolation. What is missing is a more integrative governance approach that goes beyond legislation. Development of this approach must be evidence based and involve key stakeholders to ensure acceptance by end users. The challenge is to develop a framework that coordinates the variety of actors involved in nanotechnology and civil society to facilitate consideration of the complex issues that occur in this rapidly evolving research and development area. Here, we propose three sets of essential elements required to generate an effective risk governance framework for nanomaterials. (1) Advanced tools to facilitate risk-based decision making, including an assessment of the needs of users regarding risk assessment, mitigation, and transfer. (2) An integrated model of predicted human behavior and decision making concerning nanomaterial risks. (3) Legal and other (nano-specific and general) regulatory requirements to ensure compliance and to stimulate proactive approaches to safety. The implementation of such an approach should facilitate and motivate good practice for the various stakeholders to allow the safe and sustainable future development of nanotechnology. © 2017 Society for Risk Analysis.

Computerized Adaptive Testing System Design: Preliminary Design Considerations.

DTIC Science & Technology

1982-07-01

the administrative or operational requirements of CAT and presented - # k*----.,ku nh-n.-utu (IPOI efi~g.2me (PMU tQ7q. vim NPRDC TR 82-52 July 1982...design model for a computerized adaptive testing ( CAT ) system was developed and presented through a series of hierarchy plus input-process-output (HIPO...physical system was addressed through brief discussions of hardware, software, interfaces, and personnel requirements. Further steps in CAT system

Influence of climate on landscape characteristics in safety assessments of repositories for radioactive wastes.

PubMed

Becker, J K; Lindborg, T; Thorne, M C

2014-12-01

In safety assessments of repositories for radioactive wastes, large spatial and temporal scales have to be considered when developing an approach to risk calculations. A wide range of different types of information may be required. Local to the site of interest, temperature and precipitation data may be used to determine the erosional regime (which may also be conditioned by the vegetation characteristics adopted, based both on climatic and other considerations). However, geomorphological changes may be governed by regional rather than local considerations, e.g. alteration of river base levels, river capture and drainage network reorganisation, or the progression of an ice sheet or valley glacier across the site. The regional climate is in turn governed by the global climate. In this work, a commentary is presented on the types of climate models that can be used to develop projections of climate change for use in post-closure radiological impact assessments of geological repositories for radioactive wastes. These models include both Atmosphere-Ocean General Circulation Models and Earth Models of Intermediate Complexity. The relevant outputs available from these models are identified and consideration is given to how these outputs may be used to inform projections of landscape development. Issues of spatial and temporal downscaling of climate model outputs to meet the requirements of local-scale landscape development modelling are also addressed. An example is given of how climate change and landscape development influence the radiological impact of radionuclides potentially released from the deep geological disposal facility for spent nuclear fuel that SKB (the Swedish Nuclear Fuel and Waste Management Company) proposes to construct at Forsmark, Sweden. Copyright © 2014 Elsevier Ltd. All rights reserved.

A risk-based approach to robotic mission requirements

NASA Technical Reports Server (NTRS)

Dias, William C.; Bourke, Roger D.

1992-01-01

A NASA Risk Team has developed a method for the application of risk management to the definition of robotic mission requirements for the Space Exploration Initiative. These requirements encompass environmental information, infrastructural emplacement in advance, and either technology testing or system/subsystems demonstration. Attention is presently given to a method for step-by-step consideration and analysis of the risk component inherent in mission architecture, followed by a calculation of the subjective risk level. Mitigation strategies are then applied with the same rules, and a comparison is made.

Experiment Definition Using the Space Laboratory, Long Duration Exposure Facility, and Space Transportation System Shuttle

NASA Technical Reports Server (NTRS)

Sheppard, Albert P.; Wood, Joan M.

1976-01-01

Candidate experiments designed for the space shuttle transportation system and the long duration exposure facility are summarized. The data format covers: experiment title, Experimenter, technical abstract, benefits/justification, technical discussion of experiment approach and objectives, related work and experience, experiment facts space properties used, environmental constraints, shielding requirements, if any, physical description, and sketch of major elements. Information was also included on experiment hardware, research required to develop experiment, special requirements, cost estimate, safety considerations, and interactions with spacecraft and other experiments.

Remote Sensing of In-Flight Icing Conditions: Operational, Meteorological, and Technological Considerations

NASA Technical Reports Server (NTRS)

Ryerson, Charles C.

2000-01-01

Remote-sensing systems that map aircraft icing conditions in the flight path from airports or aircraft would allow icing to be avoided and exited. Icing remote-sensing system development requires consideration of the operational environment, the meteorological environment, and the technology available. Operationally, pilots need unambiguous cockpit icing displays for risk management decision-making. Human factors, aircraft integration, integration of remotely sensed icing information into the weather system infrastructures, and avoid-and-exit issues need resolution. Cost, maintenance, power, weight, and space concern manufacturers, operators, and regulators. An icing remote-sensing system detects cloud and precipitation liquid water, drop size, and temperature. An algorithm is needed to convert these conditions into icing potential estimates for cockpit display. Specification development requires that magnitudes of cloud microphysical conditions and their spatial and temporal variability be understood at multiple scales. The core of an icing remote-sensing system is the technology that senses icing microphysical conditions. Radar and microwave radiometers penetrate clouds and can estimate liquid water and drop size. Retrieval development is needed; differential attenuation and neural network assessment of multiple-band radar returns are most promising to date. Airport-based radar or radiometers are the most viable near-term technologies. A radiometer that profiles cloud liquid water, and experimental techniques to use radiometers horizontally, are promising. The most critical operational research needs are to assess cockpit and aircraft system integration, develop avoid-and-exit protocols, assess human factors, and integrate remote-sensing information into weather and air traffic control infrastructures. Improved spatial characterization of cloud and precipitation liquid-water content, drop-size spectra, and temperature are needed, as well as an algorithm to convert sensed conditions into a measure of icing potential. Technology development also requires refinement of inversion techniques. These goals can be accomplished with collaboration among federal agencies including NASA, the FAA, the National Center for Atmospheric Research, NOAA, and the Department of Defense. This report reviews operational, meteorological, and technological considerations in developing the capability to remotely map in-flight icing conditions from the ground and from the air.

Space Tourism: Orbital Debris Considerations

NASA Astrophysics Data System (ADS)

Mahmoudian, N.; Shajiee, S.; Moghani, T.; Bahrami, M.

2002-01-01

Space activities after a phase of research and development, political competition and national prestige have entered an era of real commercialization. Remote sensing, earth observation, and communication are among the areas in which this growing industry is facing competition and declining government money. A project like International Space Station, which draws from public money, has not only opened a window of real multinational cooperation, but also changed space travel from a mere fantasy into a real world activity. Besides research activities for sending man to moon and Mars and other outer planets, space travel has attracted a considerable attention in recent years in the form of space tourism. Four countries from space fairing nations are actively involved in the development of space tourism. Even, nations which are either in early stages of space technology development or just beginning their space activities, have high ambitions in this area. This is worth noting considering their limited resources. At present, trips to space are available, but limited and expensive. To move beyond this point to generally available trips to orbit and week long stays in LEO, in orbital hotels, some of the required basic transportations, living requirements, and technological developments required for long stay in orbit are already underway. For tourism to develop to a real everyday business, not only the price has to come down to meaningful levels, but also safety considerations should be fully developed to attract travelers' trust. A serious hazard to space activities in general and space tourism in particular is space debris in earth orbit. Orbiting debris are man-made objects left over by space operations, hazardous to space missions. Since the higher density of debris population occurs in low earth orbit, which is also the same orbit of interest to space tourism, a careful attention should be paid to the effect of debris on tourism activities. In this study, after a review of the current work on space tourism and debris situation in low earth orbit suitable orbits for space tourism activities with regard to the presence of orbital debris are discussed.

The First Development of Human Factors Engineering Requirements for Application to Ground Task Design for a NASA Flight Program

NASA Technical Reports Server (NTRS)

Dischinger, H. Charles, Jr.; Stambolian, Damon B.; Miller, Darcy H.

2008-01-01

The National Aeronautics and Space Administration has long applied standards-derived human engineering requirements to the development of hardware and software for use by astronauts while in flight. The most important source of these requirements has been NASA-STD-3000. While there have been several ground systems human engineering requirements documents, none has been applicable to the flight system as handled at NASA's launch facility at Kennedy Space Center. At the time of the development of previous human launch systems, there were other considerations that were deemed more important than developing worksites for ground crews; e.g., hardware development schedule and vehicle performance. However, experience with these systems has shown that failure to design for ground tasks has resulted in launch schedule delays, ground operations that are more costly than they might be, and threats to flight safety. As the Agency begins the development of new systems to return humans to the moon, the new Constellation Program is addressing this issue with a new set of human engineering requirements. Among these requirements is a subset that will apply to the design of the flight components and that is intended to assure ground crew success in vehicle assembly and maintenance tasks. These requirements address worksite design for usability and for ground crew safety.

Requirements Flowdown for Prognostics and Health Management

NASA Technical Reports Server (NTRS)

Goebel, Kai; Saxena, Abhinav; Roychoudhury, Indranil; Celaya, Jose R.; Saha, Bhaskar; Saha, Sankalita

2012-01-01

Prognostics and Health Management (PHM) principles have considerable promise to change the game of lifecycle cost of engineering systems at high safety levels by providing a reliable estimate of future system states. This estimate is a key for planning and decision making in an operational setting. While technology solutions have made considerable advances, the tie-in into the systems engineering process is lagging behind, which delays fielding of PHM-enabled systems. The derivation of specifications from high level requirements for algorithm performance to ensure quality predictions is not well developed. From an engineering perspective some key parameters driving the requirements for prognostics performance include: (1) maximum allowable Probability of Failure (PoF) of the prognostic system to bound the risk of losing an asset, (2) tolerable limits on proactive maintenance to minimize missed opportunity of asset usage, (3) lead time to specify the amount of advanced warning needed for actionable decisions, and (4) required confidence to specify when prognosis is sufficiently good to be used. This paper takes a systems engineering view towards the requirements specification process and presents a method for the flowdown process. A case study based on an electric Unmanned Aerial Vehicle (e-UAV) scenario demonstrates how top level requirements for performance, cost, and safety flow down to the health management level and specify quantitative requirements for prognostic algorithm performance.

Holistic Design for Total Product Well Being

NASA Technical Reports Server (NTRS)

Adams, Chris W.; Hamilton, George S.

2004-01-01

Recent hardware development work at NASA's Marshall Space Flight Center creates and argument for the use of a holistic design approach as opposed to a piece part design approach. A piece part design approach being one where individual pieces are developed to their finished state having to meet certain interface and human engineering requirements without much consideration to the final product as a whole. A holistic design approach being one where the final product is evaluated early and frequently during the design process, and individual parts are developed with consideration to how they interact a whole,and how they interact with the user and environment. Examples from the development of the Materials Science Research Rack - 1 will illustrate: a design failure due to piece part design; a design save, due to a failure of piece part design, but saved by evaluating the design holistically; and a design success due to a holistic design approach.

Concept considerations for a small orbital transfer vehicle

NASA Technical Reports Server (NTRS)

Green, M.; Sibila, A. I.

1979-01-01

This paper summarizes a study of small orbital transfer vehicles to place payloads in orbits with altitudes above those of the standard Shuttle operations. The overall objective of the study is to examine the role of the small orbital transfer vehicle (SOTV) in Shuttle operations and to identify typical propulsion concepts for accomplishing the mission. Consideration is given to existing and planned systems and upper stages, along with new propulsion stages. The new propulsion concept development examines tandem and clustered solids, controlled solids, monopropellant and bipropellant liquids, and staged solid/liquid combinations. The paper presents considerations of the mission requirements, tradeoffs of the various configurations, and candidate selections. For the selected candidate concepts the performance, support equipment, operational considerations and program costs were determined. The results show that a new modular liquid stage system is cost effective in handling the majority of the payloads considered. The remainder of the payloads can be accomodated by existing systems.

Spectrum analysis on quality requirements consideration in software design documents.

PubMed

Kaiya, Haruhiko; Umemura, Masahiro; Ogata, Shinpei; Kaijiri, Kenji

2013-12-01

Software quality requirements defined in the requirements analysis stage should be implemented in the final products, such as source codes and system deployment. To guarantee this meta-requirement, quality requirements should be considered in the intermediate stages, such as the design stage or the architectural definition stage. We propose a novel method for checking whether quality requirements are considered in the design stage. In this method, a technique called "spectrum analysis for quality requirements" is applied not only to requirements specifications but also to design documents. The technique enables us to derive the spectrum of a document, and quality requirements considerations in the document are numerically represented in the spectrum. We can thus objectively identify whether the considerations of quality requirements in a requirements document are adapted to its design document. To validate the method, we applied it to commercial software systems with the help of a supporting tool, and we confirmed that the method worked well.

Considerations for the Next Revision of NASA's Space Telecommunications Radio System Architecture

NASA Technical Reports Server (NTRS)

Johnson, Sandra K.; Handler, Louis M.; Briones, Janette C.

2016-01-01

Development of NASA's Software Defined Radio architecture, the Space Telecommunication Radio System (STRS), was initiated in 2004 with a goal of reducing the cost, risk and schedule when implementing Software Defined Radios (SDR) for National Aeronautics and Space Administration (NASA) space missions. Since STRS was first flown in 2012 on three Software Defined Radios on the Space Communication and Navigation (SCaN) Testbed, only minor changes have been made to the architecture. Multiple entities have since implemented the architecture and provided significant feedback for consideration for the next revision of the standard. The focus for the first set of updates to the architecture is items that enhance application portability. Items that require modifications to existing applications before migrating to the updated architecture will only be considered if there is compelling reasons to make the change. The significant suggestions that were further evaluated for consideration include expanding and clarifying the timing Application Programming Interfaces (APIs), improving handle name and identification (ID) definitions and use, and multiple items related to implementation of STRS Devices. In addition to ideas suggested while implementing STRS, SDR technology has evolved significantly and this impact to the architecture needs to be considered. These include incorporating cognitive concepts - learning from past decisions and making new decisions that the radio can act upon. SDRs are also being developed that do not contain a General Purpose Module - which is currently required for the platform to be STRS compliant. The purpose of this paper is to discuss the comments received, provide a summary of the evaluation considerations, and examine planned dispositions.

School-to-Work Transition for Handicapped Youth: Perspectives on Educational and Economic Trends.

ERIC Educational Resources Information Center

Repetto, Jeanne B., Ed.

This compilation of papers focuses on the economic and educational considerations required for planning transitional services for handicapped youth, and was developed from the second and third annual forums sponsored by the Transitional Programming for Handicapped Youth: Interdisciplinary Leadership Preparation Program at the University of…

Teacher Disempowerment in the Education System of Ecuador

ERIC Educational Resources Information Center

Fajardo-Dack, Tammy M.

2016-01-01

A profound and systemic education change requires taking into consideration the several factors that intervene, particularly, and most importantly, the role of the teacher. Ecuador, since 2009 has been immersed in constant changes to achieve an educational transformation; however, nothing has been invested in the professional development of…

Stainless steel blanket concept for tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karbowski, J.S.; Lee, A.Y.; Prevenslik, T.V.

1979-01-25

The purpose of this joint ORNL/Westinghouse Program is to develop a design concept for a tokamak reactor blanket system which satisfies engineering requirements for a utility environment. While previous blanket studies have focused primarily on performance issues (thermal, neutronic, and structural), this study has emphasized consideration of reliability, fabricability, and lifetime.

Materials Selection. Resources in Technology.

ERIC Educational Resources Information Center

Technology Teacher, 1991

1991-01-01

This learning activity develops algorithms to ensure that the process of selecting materials is well defined and sound. These procedures require the use of many databases to provide the designer with information such as physical, mechanical, and chemical properties of the materials under consideration. A design brief, student quiz, and five…

Modeling of unit operating considerations in generating-capacity reliability evaluation. Volume 2. Computer-program documentation. Final report. [GENESIS, OPCON and OPPLAN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patton, A.D.; Ayoub, A.K.; Singh, C.

1982-07-01

This report describes the structure and operation of prototype computer programs developed for a Monte Carlo simulation model, GENESIS, and for two analytical models, OPCON and OPPLAN. It includes input data requirements and sample test cases.

Caring for the Chronically Ill: A Vital Subject for Medical Education.

ERIC Educational Resources Information Center

Cohen, Andrew J.

1998-01-01

Patients with chronic illness account for three-fourths of United States' health-care expenditures, and considerable growth in these costs is likely as the population ages. However, management of chronic illness has received little attention in either undergraduate or graduate medical education. Competencies required to develop curricula in…

Chapter 8. Management strategies for dwarf mistletoe: Silviculture

Treesearch

J. A. Muir; B. W. Geils

2002-01-01

Although there are numerous sources for information on the practice of silviculture (Forest Service 2002), special considerations are required for control of dwarf mistletoe (Scharpf and Parmeter 1978). Mistletoe-infested forests, stands, and trees develop and respond to treatment differently than their uninfested counterparts (chapter 5). The spread, intensification,...

Individual Learning Styles and Creativity

ERIC Educational Resources Information Center

Sitar, Aleša Saša; Cerne, Matej; Aleksic, Darija; Mihelic, Katarina Katja

2016-01-01

Business schools are in need of developing creative graduates. This article explores how creativity among business students can be stimulated. Because a considerable amount of knowledge is required for creative ideas to emerge, the learning process has a significant impact on creativity. This, in turn, indicates that learning style is important…

Neurodevelopmental Outcomes in Children with Cerebellar Malformations: A Systematic Review

ERIC Educational Resources Information Center

Bolduc, Marie-Eve; Limperopoulos, Catherine

2009-01-01

Cerebellar malformations are increasingly diagnosed in the fetal period. Consequently, their consideration requires stressful and often critical decisions from both clinicians and families. This has resulted in an emergent need to understand better the impact of these early life lesions on child development. We performed a comprehensive literature…

Aquaculture: A Component of Low Cost Sanitation Technology

NASA Technical Reports Server (NTRS)

Edwards, P.

1985-01-01

The paper discusses all phases of aquaculture, including commercial viability, sanitary and biological considerations, public health, financial/economic and sociological aspects. Current studies are detailed and options are discussed for their potential applicability to developing countries, considering requirements for capital and labor skills as well as physical needs such as land.

10 CFR 960.3-1 - Siting provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REPOSITORY Implementation Guidelines § 960.3-1 Siting provisions. The siting provisions establish the... repositories. As required by the Act, § 960.3-1-3 specifies consideration of a regional distribution of repositories after recommendation of a site for development of the first repository. Section 960.3-1-4...

Assistive Technology in the Schools: A Guide for Idaho Educators.

ERIC Educational Resources Information Center

Doty, Michelle; Seiler, Ron; Rhoads, LaRae

This manual is designed to provide Idaho educators, parents, students with disabilities, and related service providers with assistance in identifying, selecting, and acquiring assistive technology (AT) devices and services. The consideration of AT devices and services is required during the development of every Individualized Family Service Plan…

Multiplex immunoassay for persistent organic pollutants in tilapia: Comparison of imaging- and flow cytometry-based platforms using spectrally encoded paramagnetic microspheres

USDA-ARS?s Scientific Manuscript database

Recent developments in spectrally encoded microspheres (SEMs)-based technologies provide high multiplexing possibilities. Most SEMs-based assays required a flow cytometer with sophisticated fluidics and optics. The new imaging superparamagnetic SEMs-based platform transports SEMs with considerably ...

Moderately high intake of folic acid has a negative impact on mouse embryonic development

USDA-ARS?s Scientific Manuscript database

The incidence of neural tube defects has diminished considerably since the implementation of food fortification with folic acid (FA). However, the impact of excess FA intake, particularly during pregnancy, requires investigation. In a recent study, we reported that a diet supplemented with 20-fold h...

Using Technology to Deliver Career Development Services: Supporting Today's Students in Higher Education

ERIC Educational Resources Information Center

Venable, Melissa A.

2010-01-01

Career services professionals are increasingly involved in decisions regarding the use of technology. This article presents a number of considerations to be explored, including the characteristics and needs of today's students, available technologies, funding requirements, and confidentiality issues. The author recommends an approach that includes…

Using One Evaluation to Affect Many

ERIC Educational Resources Information Center

Ong, Angelina; Cadenhead, Christina

2015-01-01

Although visitor studies has gained in popularity in the museum field over the past decade, staff members in many institutions still believe that evaluation is a time-consuming, often complex practice that requires considerable resources and expertise. Over the past few years, evaluation professionals have begun developing innovative methods to…

Mathematical Modelling in Engineering: An Alternative Way to Teach Linear Algebra

ERIC Educational Resources Information Center

Domínguez-García, S.; García-Planas, M. I.; Taberna, J.

2016-01-01

Technological advances require that basic science courses for engineering, including Linear Algebra, emphasize the development of mathematical strengths associated with modelling and interpretation of results, which are not limited only to calculus abilities. Based on this consideration, we have proposed a project-based learning, giving a dynamic…

Learning with Technology: Using Discussion Forums to Augment a Traditional-Style Class

ERIC Educational Resources Information Center

Shana, Zuhrieh

2009-01-01

There is considerable evidence that using technology as an instructional tool improves student learning and educational outcomes (Hanna & de Nooy, 2003). In developing countries, pre-university education focuses on memorization, although meting the mission of AUST requires students to manage technology and to think more independently. This…

Onboard Inert Gas Generation System/Onboard Oxygen Gas Generation System (OBIGGS/OBOGS) Study. Part 1; Aircraft System Requirements

NASA Technical Reports Server (NTRS)

Reynolds, Thomas L.; Bailey, Delbert B.; Lewinski, Daniel F.; Roseburg, Conrad M.; Palaszewski, Bryan (Technical Monitor)

2001-01-01

The purpose of this technology assessment is to define a multiphase research study program investigating Onboard Inert Gas Generation Systems (OBIGGS) and Onboard Oxygen Generation Systems (OBOGS) that would identify current airplane systems design and certification requirements (Subtask 1); explore state-of-the-art technology (Subtask 2); develop systems specifications (Subtask 3); and develop an initial system design (Subtask 4). If feasible, consideration may be given to the development of a prototype laboratory test system that could potentially be used in commercial transport aircraft (Subtask 5). These systems should be capable of providing inert nitrogen gas for improved fire cargo compartment fire suppression and fuel tank inerting and emergency oxygen for crew and passenger use. Subtask I of this research study, presented herein, defines current production aircraft certification requirements and design objectives necessary to meet mandatory FAA certification requirements and Boeing design and performance specifications. These requirements will be utilized for baseline comparisons for subsequent OBIGGS/OBOGS application evaluations and assessments.

System considerations for detection and tracking of small targets using passive sensors

NASA Astrophysics Data System (ADS)

DeBell, David A.

1991-08-01

Passive sensors provide only a few discriminants to assist in threat assessment of small targets. Tracking of the small targets provides additional discriminants. This paper discusses the system considerations for tracking small targets using passive sensors, in particular EO sensors. Tracking helps establish good versus bad detections. Discussed are the requirements to be placed on the sensor system's accuracy, with respect to knowledge of the sightline direction. The detection of weak targets sets a requirement for two levels of tracking in order to reduce processor throughput. A system characteristic is the need to track all detections. For low thresholds, this can mean a heavy track burden. Therefore, thresholds must be adaptive in order not to saturate the processors. Second-level tracks must develop a range estimate in order to assess threat. Sensor platform maneuvers are required if the targets are moving. The need for accurate pointing, good stability, and a good update rate will be shown quantitatively, relating to track accuracy and track association.

Evaluation of the efficiency and fault density of software generated by code generators

NASA Technical Reports Server (NTRS)

Schreur, Barbara

1993-01-01

Flight computers and flight software are used for GN&C (guidance, navigation, and control), engine controllers, and avionics during missions. The software development requires the generation of a considerable amount of code. The engineers who generate the code make mistakes and the generation of a large body of code with high reliability requires considerable time. Computer-aided software engineering (CASE) tools are available which generates code automatically with inputs through graphical interfaces. These tools are referred to as code generators. In theory, code generators could write highly reliable code quickly and inexpensively. The various code generators offer different levels of reliability checking. Some check only the finished product while some allow checking of individual modules and combined sets of modules as well. Considering NASA's requirement for reliability, an in house manually generated code is needed. Furthermore, automatically generated code is reputed to be as efficient as the best manually generated code when executed. In house verification is warranted.

Design and manufacturing considerations for high-performance gimbals used for land, sea, air, and space

NASA Astrophysics Data System (ADS)

Sweeney, Mike; Redd, Lafe; Vettese, Tom; Myatt, Ray; Uchida, David; Sellers, Del

2015-09-01

High performance stabilized EO/IR surveillance and targeting systems are in demand for a wide variety of military, law enforcement, and commercial assets for land, sea, air, and space. Operating ranges, wavelengths, and angular resolution capabilities define the requirements for EO/IR optics and sensors, and line of sight stabilization. Many materials and design configurations are available for EO/IR pointing gimbals depending on trade-offs of size, weight, power (SWaP), performance, and cost. Space and high performance military aircraft applications are often driven toward expensive but exceptionally performing beryllium and aluminum beryllium components. Commercial applications often rely on aluminum and composite materials. Gimbal design considerations include achieving minimized mass and inertia simultaneous with demanding structural, thermal, optical, and scene stabilization requirements when operating in dynamic operational environments. Manufacturing considerations include precision lapping and honing of ball bearing interfaces, brazing, welding, and casting of complex aluminum and beryllium alloy structures, and molding of composite structures. Several notional and previously developed EO/IR gimbal platforms are profiled that exemplify applicable design and manufacturing technologies.

Transition of Care from Childhood to Adulthood: Turner Syndrome.

PubMed

Conway, Gerard

2018-01-01

Girls with Turner syndrome (TS) require special consideration during transition from childhood to adult care. During the transition years, treatment for short stature will be completed and sexual development induced in parallel with the peer group. The timing of sexual development may have later repercussions with respect to psychosocial development and partnership status. Late presentation of TS, which is so common, can result in additional difficulties with the transition process. © 2018 S. Karger AG, Basel.

Problems of elimination of low emission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stepniowski, A.

1995-12-31

The Cracow Municipal Gas Distribution Enterprises is subordinated to the Carpathian Regional Gas Engineering Plant in Tarnow, which - in turn - is a part of Polish Oil Mining and Gas Engineering with its seat in Warsaw. The required quick development of power engineering in Poland needs harmonized development of all branches of power engineering, including the gas production and distribution industry which constitutes an element of technical infrastructure of Poland influencing the direction of development. After World War II, the gas engineering industry was transformed from a typical communal service to a big industrial structure which covers the entiremore » territory of the state and has considerable technical and material measures at its disposal. Programming of the gas industry development ranges from development of installation of gas-supply arrangements for communal purposes including modification of local gas generators - to the development of gas transportation, storage and purification system. At present gas is taken from following sources: import, own natural gas deposits (high-methane content gas and high-nitrogen content gas within Polish Lowland); cokeries, and local gas generators. Gas sorts obtained in these sources have differentiated physico-chemical properties and they are distributed by three independent transmission systems assigned for high-methane natural gas, high-nitrogen natural gas, and coke-oven gas. Taking into consideration the forecast demand and potential capacity of natural gas production in Poland, the required import of natural gas is estimated.« less

Active Control of Cryogenic Propellants in Space

NASA Technical Reports Server (NTRS)

Notardonato, William

2011-01-01

A new era of space exploration is being planned. Exploration architectures under consideration require the long term storage of cryogenic propellants in space. This requires development of active control systems to mitigate the effect of heat leak. This work summarizes current state of the art, proposes operational design strategies and presents options for future architectures. Scaling and integration of active systems will be estimated. Ideal long range spacecraft systems will be proposed with Exploration architecture benefits considered.

Optical design concept for the Giant Magellan Telescope Multi-object Astronomical and Cosmological Spectrograph (GMACS)

NASA Astrophysics Data System (ADS)

Schmidt, Luke M.; Ribeiro, Rafael; Taylor, Keith; Jones, Damien; Prochaska, Travis; DePoy, Darren L.; Marshall, Jennifer L.; Cook, Erika; Froning, Cynthia; Ji, Tae-Geun; Lee, Hye-In; Mendes de Oliveira, Claudia; Pak, Soojong; Papovich, Casey

2016-08-01

We present a preliminary conceptual optical design for GMACS, a wide field, multi-object, optical spectrograph currently being developed for the Giant Magellan Telescope (GMT). We include details of the optical design requirements derived from the instrument scientific and technical objectives and demonstrate how these requirements are met by the current design. Detector specifications, field acquisition/alignment optics, and optical considerations for the active flexure control system are also discussed.

Structural design considerations for the beam transmission optical system

NASA Technical Reports Server (NTRS)

Macneal, Paul D.; Lou, Michael C.

1993-01-01

The paper describes the JPL study leading to a baseline design of the Beam Transmission Optical System (BTOS), designed for the delivery of laser energy from earth to space targets. The study identified the driving environmental and functional requirements; developed a conceptual design of the BTOS telescope; and performed static, thermal distortion, and model analyses to verify that these requirements are met. The study also identified major areas of concern which should be investigated further.

The optics inside an automated single molecule array analyzer

NASA Astrophysics Data System (ADS)

McGuigan, William; Fournier, David R.; Watson, Gary W.; Walling, Les; Gigante, Bill; Duffy, David C.; Rissin, David M.; Kan, Cheuk W.; Meyer, Raymond E.; Piech, Tomasz; Fishburn, Matthew W.

2014-02-01

Quanterix and Stratec Biomedical have developed an instrument that enables the automated measurement of multiple proteins at concentration ~1000 times lower than existing immunoassays. The instrument is based on Quanterix's proprietary Single Molecule Array technology (Simoa™ ) that facilitates the detection and quantification of biomarkers previously difficult to measure, thus opening up new applications in life science research and in-vitro diagnostics. Simoa is based on trapping individual beads in arrays of femtoliter-sized wells that, when imaged with sufficient resolution, allows for counting of single molecules associated with each bead. When used to capture and detect proteins, this approach is known as digital ELISA (Enzyme-linked immunosorbent assay). The platform developed is a merger of many science and engineering disciplines. This paper concentrates on the optical technologies that have enabled the development of a fully-automated single molecule analyzer. At the core of the system is a custom, wide field-of-view, fluorescence microscope that images arrays of microwells containing single molecules bound to magnetic beads. A consumable disc containing 24 microstructure arrays was developed previously in collaboration with Sony DADC. The system cadence requirements, array dimensions, and requirement to detect single molecules presented significant optical challenges. Specifically, the wide field-of-view needed to image the entire array resulted in the need for a custom objective lens. Additionally, cost considerations for the system required a custom solution that leveraged the image processing capabilities. This paper will discuss the design considerations and resultant optical architecture that has enabled the development of an automated digital ELISA platform.

FEL (free-electron lasers) undulator technology and synchrotron radiation source requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robinson, K.; Quimby, D.; Slater, J.

This paper describes design and construction considerations of the THUNDER undulator, for use in free-electron laser experiments at visible wavelengths. For the parameters of these experiments, an unusually high degree of optimization of the electron-photon interaction is required and, as a result, THUNDER is built to especially high mechanical and magnetic precision. Except for its narrow magnet gap, the 5-meter THUNDER undulator is quite similar to insertion devices under consideration for the proposed 6-GeV storage ring. The engineering and physics approach adopted for this FEL modulator design is directly applicable to insertion device development. The tolerance limits to THUNDER, establishedmore » by modeling and design and achieved through careful control of mechanical and magnetic errors, are essential to the next generation of insertion devices.« less

Permeability and flammability study of composite sandwich structures for cryogenic applications

NASA Astrophysics Data System (ADS)

Bubacz, Monika

Fiber reinforced plastics offer advantageous specific strength and stiffness compared to metals and has been identified as candidates for the reusable space transportation systems primary structures including cryogenic tanks. A number of carbon and aramid fiber reinforced plastics have been considered for the liquid hydrogen tanks. Materials selection is based upon mechanical properties and containment performance (long and short term) and upon manufacturing considerations. The liquid hydrogen tank carries shear, torque, end load, and bending moment due to gusts, maneuver, take-off, landing, lift, drag, and fuel sloshing. The tank is pressurized to about 1.5 atmosphere (14.6psi or 0.1 MPa) differential pressure and on ascent maintains the liquid hydrogen at a temperature of 20K. The objective of the research effort into lay the foundation for developing the technology required for reliable prediction of the effects of various design, manufacturing, and service parameters on the susceptibility of composite tanks to develop excessive permeability to cryogenic fuels. Efforts will be expended on developing the materials and structural concepts for the cryogenic tanks that can meet the functional requirements. This will include consideration for double wall composite sandwich structures, with inner wall to meet the cryogenic requirements. The structure will incorporate nanoparticles for properties modifications and developing barriers. The main effort will be extended to tank wall's internal skin design. The main requirements for internal composite stack are: (1) introduction of barrier film (e.g. honeycomb material paper sheet) to reduce the wall permeability to hydrogen, (2) introduction of nanoparticles into laminate resin to prevent micro-cracking or crack propagation. There is a need to characterize and analyze composite sandwich structural damage due to burning and explosion. Better understanding of the flammability and blast resistance of the composite structures needs to be evaluated.

Recommendations for Planning and Managing International Short-term Pharmacy Service Trips

PubMed Central

Alsharif, Naser Z.; Rovers, John; Connor, Sharon; White, Nicole D.; Hogue, Michael D.

2017-01-01

International pharmacy service trips by schools and colleges of pharmacy allow students to provide health care to medically underserved areas. A literature review (2000-2016) in databases and Internet searches with specific keywords or terms was performed to assess current practices to establish and maintain successful pharmacy service trips. Educational documents such as syllabi were obtained from pharmacy programs and examined. A preliminary draft was developed and authors worked on sections of interest and expertise. Considerations and current recommendations are provided for the key aspects of the home institution and the host country requirements for pharmacy service trips based on findings from a literature search and the authors’ collective, extensive experience. Evaluation of the trip and ethical considerations are also discussed. This article serves as a resource for schools and colleges of pharmacy that are interested in the development of new pharmacy service trips and provides key considerations for continuous quality improvement of current or future activities. PMID:28381883

Recommendations for Planning and Managing International Short-term Pharmacy Service Trips.

PubMed

Johnson, Kalin L; Alsharif, Naser Z; Rovers, John; Connor, Sharon; White, Nicole D; Hogue, Michael D

2017-03-25

International pharmacy service trips by schools and colleges of pharmacy allow students to provide health care to medically underserved areas. A literature review (2000-2016) in databases and Internet searches with specific keywords or terms was performed to assess current practices to establish and maintain successful pharmacy service trips. Educational documents such as syllabi were obtained from pharmacy programs and examined. A preliminary draft was developed and authors worked on sections of interest and expertise. Considerations and current recommendations are provided for the key aspects of the home institution and the host country requirements for pharmacy service trips based on findings from a literature search and the authors' collective, extensive experience. Evaluation of the trip and ethical considerations are also discussed. This article serves as a resource for schools and colleges of pharmacy that are interested in the development of new pharmacy service trips and provides key considerations for continuous quality improvement of current or future activities.

Achieving the Proper Balance Between Crew and Public Safety

NASA Technical Reports Server (NTRS)

Gowan, John; Silvestri, Ray; Stahl, Ben; Rosati, Paul; Wilde, Paul

2011-01-01

A paramount objective of all human-rated launch and reentry vehicle developers is to ensure that the risks to both the crew onboard and the public are minimized within reasonable cost, schedule, and technical constraints. Past experience has shown that proper attention to range safety requirements necessary to ensure public safety must be given early in the design phase to avoid additional operational complexities or threats to the safety of people onboard, and the design engineers must give these requirements the same consideration as crew safety requirements. For human spaceflight, the primary purpose and operational concept for any flight safety system is to protect the public while maximizing the likelihood of crew survival. This paper will outline the policy considerations, technical issues, and operational impacts regarding launch and reentry vehicle failure scenarios where crew and public safety are intertwined and thus addressed optimally in an integrated manner. An overview of existing range and crew safety policy requirements will be presented. Application of these requirements and lessons learned from both the Space Shuttle and Constellation Programs will also be discussed. Using these past programs as examples, the paper will detail operational, design, and analysis approaches to mitigate and balance the risks to people onboard and in the public. Manned vehicle perspectives from the Federal Aviation Administration (FAA) and Air Force organizations that oversee public safety will be summarized as well. Finally, the paper will emphasize the need to factor policy, operational, and analysis considerations into the early design trades of new vehicles to help ensure that both crew and public safety are maximized to the greatest extent possible.

Achieving the Proper Balance between Crew & Public Safety

NASA Astrophysics Data System (ADS)

Wilde, P.; Gowan, J.; Silvestri, R.; Stahl, B.; Rosati, P.

2012-01-01

A paramount objective of all human-rated launch and reentry vehicle developers is to ensure that the risks to both the crew onboard and the public are minimized within reasonable cost, schedule, and technical constraints. Past experience has shown that proper attention to range safety requirements necessary to ensure public safety must be given early in the design phase to avoid additional operational complexities or threats to the safety of people onboard, and the design engineers must give these requirements the same consideration as crew safety requirements. For human spaceflight, the primary purpose and operational concept for any flight safety system is to protect the public while maximizing the likelihood of crew survival. This paper will outline the policy considerations, technical issues, and operational impacts regarding launch and reentry vehicle failure scenarios where crew and public safety are intertwined and thus addressed optimally in an integrated manner. An overview of existing range and crew safety policy requirements will be presented. Application of these requirements and lessons learned from both the Space Shuttle and Constellation Programs will also be discussed. Using these past programs as examples, the paper will detail operational, design, and analysis approaches to mitigate and balance the risks to people onboard and in the public. Crewed vehicle perspectives from the Federal Aviation Administration and Air Force organizations that oversee public safety will be summarized as well. Finally, the paper will emphasize the need to factor policy, operational, and analysis considerations into the early design trades of new vehicles to help ensure that both crew and public safety are maximized to the greatest extent possible.

Nuclear safety policy working group recommendations on nuclear propulsion safety for the space exploration initiative

NASA Technical Reports Server (NTRS)

Marshall, Albert C.; Lee, James H.; Mcculloch, William H.; Sawyer, J. Charles, Jr.; Bari, Robert A.; Cullingford, Hatice S.; Hardy, Alva C.; Niederauer, George F.; Remp, Kerry; Rice, John W.

1993-01-01

An interagency Nuclear Safety Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program. These recommendations, which are contained in this report, should facilitate the implementation of mission planning and conceptual design studies. The NSPWG has recommended a top-level policy to provide the guiding principles for the development and implementation of the SEI nuclear propulsion safety program. In addition, the NSPWG has reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. These recommendations should be useful for the development of the program's top-level requirements for safety functions (referred to as Safety Functional Requirements). The safety requirements and guidelines address the following topics: reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations.

ASTEC—the Aarhus STellar Evolution Code

NASA Astrophysics Data System (ADS)

Christensen-Dalsgaard, Jørgen

2008-08-01

The Aarhus code is the result of a long development, starting in 1974, and still ongoing. A novel feature is the integration of the computation of adiabatic oscillations for specified models as part of the code. It offers substantial flexibility in terms of microphysics and has been carefully tested for the computation of solar models. However, considerable development is still required in the treatment of nuclear reactions, diffusion and convective mixing.

Spacecraft sanitation agent development

NASA Technical Reports Server (NTRS)

1972-01-01

The development of an effective sanitizing agent that is compatible with the spacecraft environment and the human occupant is discussed. Experimental results show that two sanitation agents must be used to satisfy mission requirements: one agent for personal hygiene and one for equipment maintenance. It was also recommended that a water rinse be used with the agents for best results, and that consideration be given to using the agents pressure packed or in aerosol formulations.

YJ101-YF-17 Aircraft Prototype Development Summary

DTIC Science & Technology

1977-01-01

requirements were selected to evaluate engi of the considerations was the impact of idl operation, while other arenas as altitude f loads , EMI, and JP...designed to be compatible with the air combat fighter installation environment temperatures and "g" loads . 2.2.1 Evaluation Testing Program. An...ratio per stage. It has a cylindrical hub and tapered tip flowpath to provide high loading within reasonable rim speeds. Development

Airborne Laser Remote Sensor for Oil Detection and Classification : Engineering Requirements and Technical Considerations Relevant to a Performance Specification

DOT National Transportation Integrated Search

1975-08-01

This report outlines the engineering requirements for an Airborne Laser Remote Sensor for Oil Detection and Classification System. Detailed engineering requirements are given for the major units of the system. Technical considerations pertinent to a ...

21 CFR 25.20 - Actions requiring preparation of an environmental assessment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Actions requiring preparation of an environmental assessment. 25.20 Section 25.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ENVIRONMENTAL IMPACT CONSIDERATIONS Agency Actions Requiring Environmental Consideration...

CMOS array design automation techniques. [metal oxide semiconductors

NASA Technical Reports Server (NTRS)

Ramondetta, P.; Feller, A.; Noto, R.; Lombardi, T.

1975-01-01

A low cost, quick turnaround technique for generating custom metal oxide semiconductor arrays using the standard cell approach was developed, implemented, tested and validated. Basic cell design topology and guidelines are defined based on an extensive analysis that includes circuit, layout, process, array topology and required performance considerations particularly high circuit speed.

Higher Education Profiles and Trends, 2009

ERIC Educational Resources Information Center

Tennessee Higher Education Commission, 2009

2009-01-01

Tennessee Code Annotated (T.C.A.) Section 49-7-2 (c) (7) requires the Tennessee Higher Education Commission to "submit a biennial report to the governor and the general assembly, commenting upon major developments, trends, new policies, budgets and financial considerations which in the judgment of the commission will be useful to the governor…

Tennessee Higher Education Profiles and Trends, 2010

ERIC Educational Resources Information Center

Tennessee Higher Education Commission, 2010

2010-01-01

Tennessee Code Annotated (T.C.A.) Section 49-7-202 (c) (7) requires the Tennessee Higher Education Commission to "submit a biennial report to the governor and the general assembly, commenting upon major developments, trends, new policies, budgets and financial considerations which in the judgment of the commission will be useful to the…

Tennessee Higher Education Profiles and Trends, 2008

ERIC Educational Resources Information Center

Tennessee Higher Education Commission, 2008

2008-01-01

Tennessee Code Annotated (T.C.A.) Section 49-7-202 (c) (7) requires the Tennessee Higher Education Commission to "submit a biennial report to the governor and the general assembly, commenting upon major developments, trends, new policies, budgets and financial considerations which in the judgment of the commission will be useful to the…

Influence of Learning Styles on Graphical User Interface Preferences for e-Learners

ERIC Educational Resources Information Center

Dedic, Velimir; Markovic, Suzana

2012-01-01

Implementing Web-based educational environment requires not only developing appropriate architectures, but also incorporating human factors considerations. User interface becomes the major channel to convey information in e-learning context: a well-designed and friendly enough interface is thus the key element in helping users to get the best…

Assessment of native species and ungulate grazing in the Southwest: Terrestrial wildlife

Treesearch

Patrick W. Zwartjes; Jean-Luc E. Cartron; Pamela L. L. Stoleson; Walter C. Haussamen; Tiffany E Crane

2005-01-01

Range managers in the Southwestern States are increasingly being required to develop management strategies that take into consideration the conservation of wildlife populations. However, information on many aspects of the fundamental biology and impacts of grazing on individual species is still lacking in the scientific and government literature. This report documents...

Framing the International Studies Curriculum: Toward the Development of Common Student Learning Outcomes

ERIC Educational Resources Information Center

Chernotsky, Harry I.

2013-01-01

Unlike most disciplinary-based academic programs, interdisciplinary international studies programs vary considerably in terms of their core curricula. They need to fit within the institutional context in which they operate and must insure that there are sufficient faculty and resources available so that required courses are accessible on a regular…

75 FR 3745 - NIH Consensus Development Conference on Vaginal Birth After Cesarean: New Insights; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

... clinicians believed that all of her future pregnancies required delivery by cesarean as well. However, in... placental problems in future pregnancies. Other important considerations that may influence decisionmaking... the pregnancy is relative to her due date, and the size and position of her baby. Given the complexity...

The NTF as a national facility. [project planning

NASA Technical Reports Server (NTRS)

Nicks, O. W.

1977-01-01

Activities which led to the definition of the National Transonic Facility and the general agreements reached regarding its use and operations are reviewed. Topics discussed include: redefinition of test requirements, development of low cost options, consideration of a single transonic facility using existing hardware if feasible, facility concept recommendations, and acquisition schedule proposals.

WEIGHING THE EVIDENCE OF ECOLOGICAL RISK OF CHEMICAL CONTAMINATION IN THE ESTUARINE ENVIRONMENT ADJACENT TO THE PORTSMOUTH NAVAL SHIPYARD, KITTERY, MAINE, USA

EPA Science Inventory

In characterizing ecological risks, considerable consensus building and professional judgments are required to develop conclusions about risk. This is because how to evaluate all the factors that determine ecological risk is not well defined and is subject to interpretation. Here...

Ecological support for rural land-use planning.

Treesearch

David M. Theobald; Thomas Spies; Jeff Kline; Bruce Maxwell; N. T. Hobbs; Virginia H. Dale

2005-01-01

How can ecologists be more effective in supporting ecologically informed rural land-use planning and policy? Improved decision making about rural lands requires careful consideration of how ecological information and analyses can inform specific planning and policy needs. We provide a brief overview of rural land-use planning, including recently developed approaches to...

Higher Education Profiles & Trends 2013

ERIC Educational Resources Information Center

Tennessee Higher Education Commission, 2013

2013-01-01

The statute [T.C.A. Section 49-7-202(c)(7)] requires the Tennessee Higher Education Commission to prepare a biennial report for the governor and the general assembly, "commenting upon major developments, trends, new policies, budgets and financial considerations which in the judgment of the commission will be useful to the governor and to the…

Environmentally Sound Small-Scale Agricultural Projects: Guidelines for Planning. Revised Edition.

ERIC Educational Resources Information Center

Altieri, Miguel; Vukasin, Helen L., Ed.

Environmental planning requires more than finding the right technology and a source of funds. Planning involves consideration of the social, cultural, economic, and natural environments in which the project occurs. The challenge is to develop sustainable food systems that have reasonable production but do not degrade the resource base and upset…

Dynamic balance improvement program

NASA Technical Reports Server (NTRS)

Butner, M. F.

1983-01-01

The reduction of residual unbalance in the space shuttle main engine (SSME) high pressure turbopump rotors was addressed. Elastic rotor response to unbalance and balancing requirements, multiplane and in housing balancing, and balance related rotor design considerations were assessed. Recommendations are made for near term improvement of the SSME balancing and for future study and development efforts.

Spectral peculiarities of electromagnetic wave scattering by Veselago's cylinders

NASA Astrophysics Data System (ADS)

Sukhov, S. V.; Shevyakhov, N. S.

2006-03-01

The results are presented of spectral calculations of extinction cross-section for scattering of E- and H-polarized electromagnetic waves by cylinders made of Veselago material. The insolvency of previously developed models of scattering is demonstrated. It is shown that correct description of scattering requires separate consideration of both electric and magnetic subsystems.

Spectral peculiarities of electromagnetic wave scattered by Veselago's cylinders

NASA Astrophysics Data System (ADS)

Sukhov, S. V.; Shevyakhov, N. S.

2005-09-01

The results are presented of spectral calculations of extinction cross-section for scattering of E- and H-polarized electromagnetic waves by cylinders made of Veselago material. The insolvency of previously developed models of scattering is demonstrated. It is shown that correct description of scattering requires separate consideration of both electric and magnetic subsystems.

Conserving and Enhancing the Natural Environment: A Guide for Planning, Design, Construction, and Maintenance on New & Existing School Sites.

ERIC Educational Resources Information Center

Maryland State Dept. of Education, Baltimore. School Facilities Branch.

Natural environments on school sites provide considerable multi-disciplinary educational opportunities, many of which are "hands-on" experiences that stimulate learning. This document presents guidelines on conserving and enhancing the natural environment on school sites. It provides guidance for developing the site requirements in…

Enhancement of Spatial Thinking with Virtual Spaces 1.0

ERIC Educational Resources Information Center

Hauptman, Hanoch

2010-01-01

Developing a software environment to enhance 3D geometric proficiency demands the consideration of theoretical views of the learning process. Simultaneously, this effort requires taking into account the range of tools that technology offers, as well as their limitations. In this paper, we report on the design of Virtual Spaces 1.0 software, a…

NASA/ESACV-990 spacelab simulation. Appendix B: Experiment development and performance

NASA Technical Reports Server (NTRS)

Reller, J. O., Jr.; Neel, C. B.; Haughney, L. C.

1976-01-01

Eight experiments flown on the CV-990 airborne laboratory during the NASA/ESA joint Spacelab simulation mission are described in terms of their physical arrangement in the aircraft, their scientific objectives, developmental considerations dictated by mission requirements, checkout, integration into the aircraft, and the inflight operation and performance of the experiments.

Closing the Gap between Research Evidence and Clinical Practice: Jordanian Nurses' Perceived Barriers to Research Utilisation

ERIC Educational Resources Information Center

Al Khalaileh, Murad; Al Qadire, Mohammad; Musa, Ahmad S.; Al-Khawaldeh, Omar A.; Al Qudah, Hani; Alhabahbeh, Atalla

2016-01-01

Background: The nursing profession is a combination of theory and practical skill, and nurses are required to generate and develop knowledge through implementing research into clinical practice. Considerable number of barriers could hind implementing research findings into practice. Barriers to research utilisation are not identified in the…

Relative Costs of Various Types of Assessments.

ERIC Educational Resources Information Center

Wheeler, Patricia H.

Issues of the relative costs of multiple choice tests and alternative types of assessment are explored. Before alternative assessments in large-scale or small-scale programs are used, attention must be given to cost considerations and the resources required to develop and implement the assessment. Major categories of cost to be considered are…

Design Considerations for Developing Biodegradable Magnesium Implants

NASA Astrophysics Data System (ADS)

Brar, Harpreet S.; Keselowsky, Benjamin G.; Sarntinoranont, Malisa; Manuel, Michele V.

The integration of biodegradable and bioabsorbable magnesium implants into the human body is a complex undertaking that faces major challenges. The complexity arises from the fact that biomaterials must meet both engineering and physiological requirements to ensure the desired properties. Historically, efforts have been focused on the behavior of commercial magnesium alloys in biological environments and their resultant effect on cell-mediated processes. Developing causal relationships between alloy chemistry and micro structure, and its effect on cellular behavior can be a difficult and time intensive process. A systems design approach driven by thermodynamics has the power to provide significant contributions in developing the next generation of magnesium alloy implants with controlled degradability, biocompatibility, and optimized mechanical properties, at reduced time and cost. This approach couples experimental research with theory and mechanistic modeling for the accelerated development of materials. The aim of this article is to enumerate this strategy, design considerations and hurdles for developing new magnesium alloys for use as biodegradable implant materials [1].

Source Recertification, Refurbishment, and Transfer Logistics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gastelum, Zoe N.; Duckworth, Leesa L.; Greenfield, Bryce A.

2013-09-01

The 2012 Gap Analysis of Department of Energy Radiological Sealed Sources, Standards, and Materials for Safeguards Technology Development [1] report, and the subsequent Reconciliation of Source Needs and Surpluses across the U.S. Department of Energy National Laboratory Complex [2] report, resulted in the identification of 33 requests for nuclear or radiological sealed sources for which there was potentially available, suitable material from within the U.S. Department of Energy (DOE) complex to fill the source need. Available, suitable material was defined by DOE laboratories as material slated for excess, or that required recertification or refurbishment before being used for safeguards technologymore » development. This report begins by outlining the logistical considerations required for the shipment of nuclear and radiological materials between DOE laboratories. Then, because of the limited need for transfer of matching sources, the report also offers considerations for an alternative approach – the shipment of safeguards equipment between DOE laboratories or technology testing centers. Finally, this report addresses repackaging needs for the two source requests for which there was available, suitable material within the DOE complex.« less

Fluctuations in energy loss and their implications for dosimetry and radiobiology

NASA Technical Reports Server (NTRS)

Baily, N. A.; Steigerwalt, J. E.

1972-01-01

Serious consideration of the physics of energy deposition indicates that a fundamental change in the interpretation of absorbed dose is required at least for considerations of effects in biological systems. In addition, theoretical approaches to radiobiology and microdosimetry seem to require statistical considerations incorporating frequency distributions of the magnitude of the event sizes within the volume of interest.

Nurses’ Perceptions of Critical Issues Requiring Consideration in the Development of Guidelines for Professional Registered Nurse Staffing for Perinatal Units

PubMed Central

Simpson, Kathleen Rice; Lyndon, Audrey; Wilson, Jane; Ruhl, Catherine

2012-01-01

Objective To solicit input from registered nurse members of the Association of Women’s Health, Obstetric and Neonatal Nurses (AWHONN) on critical considerations for review and revision of existing nurse staffing guidelines. Design Thematic analysis of responses to a cross-sectional on-line survey question: “Please give the staffing task force your input on what they should consider in the development of recommendations for staffing of perinatal units.” Participants N = 884 AWHONN members. Main Outcome Measure Descriptions of staffing concerns that should be considered when evaluating and revising existing perinatal nurse staffing guidelines. Results Consistent themes identified included the need for revision of nurse staffing guidelines due to requirements for safe care, increases in patient acuity and complexity, invisibility of the fetus and newborn as separate and distinct patients, difficulties in providing comprehensive care during labor and for mother-baby couplets under current conditions, challenges in staffing small volume units, and the negative effect of inadequate staffing on nurse satisfaction and retention. Conclusion Participants overwhelmingly indicated current nurse staffing guidelines were inadequate to meet the needs of contemporary perinatal clinical practice and required revision based on significant changes that had occurred since 1983 when the original staffing guidelines were published. PMID:22690743

Development of Oxidation Resistant Coatings on GRCop-84 Substrates by Cold Spray Process

NASA Technical Reports Server (NTRS)

Karthikeyan, J.

2007-01-01

GRCop-84, a Cu-CR-Nb alloy, has been developed for rocket engine liner applications. For maximum life additional oxidation protection is required to prevent blanching. NiCrAlY was identified as a suitable coating, and efforts were initiated to develop suitable coating techniques. Cold spray is one technique under consideration. Efforts at ASB Industries to produce dense, adherent coatings are detailed. The work culminated in the production of samples for testing at NASA Glenn Research Center.

GCS programmer's manual

NASA Technical Reports Server (NTRS)

Lowman, Douglas S.; Withers, B. Edward; Shagnea, Anita M.; Dent, Leslie A.; Hayhurst, Kelly J.

1990-01-01

A variety of instructions to be used in the development of implementations of software for the Guidance and Control Software (GCS) project is described. This document fulfills the Radio Technical Commission for Aeronautics RTCA/DO-178A guidelines, 'Software Considerations in Airborne Systems and Equipment Certification' requirements for document No. 4, which specifies the information necessary for understanding and programming the host computer, and document No. 12, which specifies the software design and implementation standards that are applicable to the software development and testing process. Information on the following subjects is contained: activity recording, communication protocol, coding standards, change management, error handling, design standards, problem reporting, module testing logs, documentation formats, accuracy requirements, and programmer responsibilities.

Instrument control software requirement specification for Extremely Large Telescopes

NASA Astrophysics Data System (ADS)

Young, Peter J.; Kiekebusch, Mario J.; Chiozzi, Gianluca

2010-07-01

Engineers in several observatories are now designing the next generation of optical telescopes, the Extremely Large Telescopes (ELT). These are very complex machines that will host sophisticated astronomical instruments to be used for a wide range of scientific studies. In order to carry out scientific observations, a software infrastructure is required to orchestrate the control of the multiple subsystems and functions. This paper will focus on describing the considerations, strategies and main issues related to the definition and analysis of the software requirements for the ELT's Instrument Control System using modern development processes and modelling tools like SysML.

Loads and low frequency dynamics - An ENVIRONET data base

NASA Technical Reports Server (NTRS)

Garba, John A.

1988-01-01

The loads and low frequency dynamics data base, part of Environet, is described with particular attention given to its development and contents. The objective of the data base is to provide the payload designer with design approaches and design data to meet STS safety requirements. Currently the data base consists of the following sections: abstract, scope, glossary, requirements, interaction with other environments, summary of the loads analysis process, design considerations, guidelines for payload design loads, information data base, and references.

Method for determining how to operate and control wind turbine arrays in utility systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Javid, S.H.; Hauth, R.L.; Younkins, T.D.

1984-01-01

A method for determining how utility wind turbine arrays should be controlled and operated on the load frequency control time-scale is presented. Initial considerations for setting wind turbine control requirements are followed by a description of open loop operation and of closed loop and feed forward wind turbine array control concepts. The impact of variations in array output on meeting minimum criteria are developed. The method for determining the required control functions is then presented and results are tabulated. (LEW)

Small Business Innovations (Helicopters)

NASA Technical Reports Server (NTRS)

1992-01-01

The amount of engine power required for a helicopter to hover is an important, but difficult, consideration in helicopter design. The EHPIC program model produces converged, freely distorted wake geometries that generate accurate analysis of wake-induced downwash, allowing good predictions of rotor thrust and power requirements. Continuum Dynamics, Inc., the Small Business Innovation Research (SBIR) company that developed EHPIC, also produces RotorCRAFT, a program for analysis of aerodynamic loading of helicopter blades in forward flight. Both helicopter codes have been licensed to commercial manufacturers.

Transmitter experiment package for the communications technology satellite

NASA Technical Reports Server (NTRS)

Farber, B.; Goldin, D. S.; Marcus, B.; Mock, P.

1977-01-01

The operating requirements, system design characteristics, high voltage packaging considerations, nonstandard components development, and test results for the transmitter experiment package (TEP) are described. The TEP is used for broadcasting power transmission from the Communications Technology Satellite. The TEP consists of a 12 GHz, 200-watt output stage tube (OST), a high voltage processing system that converts the unregulated spacecraft solar array power to the regulated voltages required for OST operation, and a variable conductance heat pipe system that is used to cool the OST body.

Large Energy Development Projects: Lessons Learned from Space and Politics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmitt, Harrison H.

2005-04-15

The challenge to global energy future lies in meeting the needs and aspirations of the ten to twelve billion earthlings that will be on this planet by 2050. At least an eight-fold increase in annual production will be required by the middle of this century. The energy sources that can be considered developed and 'in the box' for consideration as sources for major increases in supply over the next half century are fossil fuels, nuclear fission, and, to a lesser degree, various forms of direct and stored solar energy and conservation. None of these near-term sources of energy will providemore » an eight-fold or more increase in energy supply for various technical, environmental and political reasons.Only a few potential energy sources that fall 'out of the box' appear worthy of additional consideration as possible contributors to energy demand in 2050 and beyond. These particular candidates are deuterium-tritium fusion, space solar energy, and lunar helium-3 fusion. The primary advantage that lunar helium-3 fusion will have over other 'out of the box' energy sources in the pre-2050 timeframe is a clear path into the private capital markets. The development and demonstration of new energy sources will require several development paths, each of Apollo-like complexity and each with sub-paths of parallel development for critical functions and components.« less

Considerations for developing technologies for an integrated person-borne IED countermeasure architecture

NASA Astrophysics Data System (ADS)

Lombardo, Nicholas J.; Knudson, Christa K.; Rutz, Frederick C.; Pattison, Kerrie J.; Stratton, Rex C.; Wiborg, James C.

2010-04-01

Developing an integrated person-borne improvised explosive device (IED) countermeasure to protect unstructured crowds at large public venues is the goal of the Standoff Technology Integration and Demonstration Program (STIDP), sponsored in part by the U.S. Department of Homeland Security (DHS). The architecture being developed includes countermeasure technologies deployed as a layered defense and enabling technologies for operating the countermeasures as an integrated system. In the architecture, early recognition of potentially higher-risk individuals is crucial. Sensors must be able to detect, with high accuracy, explosives' threat signatures in varying environmental conditions, from a variety of approaches and with dense crowds and limited dwell time. Command-and-control technologies are needed to automate sensor operation, reduce staffing requirements, improve situational awareness, and automate/facilitate operator decisions. STIDP is developing technical and operational requirements for standoff and remotely operated sensors and is working with federal agencies and foreign governments to implement these requirements into their research and development programs. STIDP also is developing requirements for a software platform to rapidly integrate and control various sensors; acquire, analyze, and record their data; and present the data in an operationally relevant manner. Requirements also are being developed for spatial analysis, tracking and assessing threats with available screening resources, and data fusion for operator decision-making.

Mainstreaming Climate Change: Recent and Ongoing Efforts to Understand, Improve, and Expand Consideration of Climate Change in Federal Water Resources Planning

NASA Astrophysics Data System (ADS)

Ferguson, I. M.; McGuire, M.; Broman, D.; Gangopadhyay, S.

2017-12-01

The Bureau of Reclamation is a Federal agency tasked with developing and managing water supply and hydropower projects in the Western U.S. Climate and hydrologic variability and change significantly impact management actions and outcomes across Reclamation's programs and initiatives, including water resource planning and operations, infrastructure design and maintenance, hydropower generation, and ecosystem restoration, among others. Planning, design, and implementation of these programs therefore requires consideration of future climate and hydrologic conditions will impact program objectives. Over the past decade, Reclamation and other Federal agencies have adopted new guidelines, directives, and mandates that require consideration of climate change in water resources planning and decision making. Meanwhile, the scientific community has developed a large number of climate projections, along with an array of models, methods, and tools to facilitate consideration of climate projections in planning and decision making. However, water resources engineers, planners, and decision makers continue to face challenges regarding how best to use the available data and tools to support major decisions, including decisions regarding infrastructure investments and long-term operating criteria. This presentation will discuss recent and ongoing research towards understanding, improving, and expanding consideration of climate projections and related uncertainties in Federal water resources planning and decision making. These research efforts address a variety of challenges, including: How to choose between available climate projection datasets and related methods, models, and tools—many of which are considered experimental or research tools? How to select an appropriate decision framework when design or operating alternatives may differ between climate scenarios? How to effectively communicate results of a climate impacts analysis to decision makers? And, how to improve robustness and resilience of water resources systems in the face of significant uncertainty? Discussion will focus on the intersection between technical challenges and decision making paradigms and the need for improved scientist-decision maker engagement through the lens of this Federal water management agency.

Using a Geographic Information System to Assess Site Suitability for Managed Aquifer Recharge using Stormwater Capture

NASA Astrophysics Data System (ADS)

Teo, E. K.; Harmon, R. E.; Beganskas, S.; Young, K. S.; Fisher, A. T.; Weir, W. B.; Lozano, S.

2015-12-01

We are completing a regional analysis of Santa Cruz and northern Monterey Counties, CA, to assess the conditions amenable to managed aquifer recharge using stormwater runoff. Communities and water supply agencies across CA are struggling to mitigate the ongoing drought and to develop secure and sustainable water supplies to support long-term municipal, agricultural, environmental and other needs. Enhanced storage of groundwater is an important part of this effort in many basins. This work is especially timely because of the recently enacted "Sustainable Groundwater Management Act" (SGMA), which requires the development of groundwater sustainability agencies and implementation of basin management plans in coming decades. Our analysis focuses specifically on the distributed collection of stormwater runoff, a water source that has typically been treated as a nuisance or waste, from drainages having an area on the order of 40-160 hectares. The first part of this project is a geographic information system (GIS) analysis using surface and subsurface data sets. Developing complete and accurate datasets across the study region required considerable effort to locate, assemble, co-register, patch, and reconcile information from many sources and scales. We have complete spatial coverage for surface data, but subsurface data is more limited in lateral extent. Sites that are most suitable for distributed stormwater capture supporting MAR have high soil infiltration capacity, are well-connected to an underlying aquifer with good transmissive and storage properties, and have space to receive MAR. Additional considerations include method of infiltration, slope, and land use and access. Based on initial consideration of surface data and slope, 7% of the complete study region appears to be "suitable or highly suitable" for MAR (in the top third of the rating system), but there is considerable spatial heterogeneity based on the distribution of shallow soils and bedrock geology.

TRENDS: The aeronautical post-test database management system

NASA Technical Reports Server (NTRS)

Bjorkman, W. S.; Bondi, M. J.

1990-01-01

TRENDS, an engineering-test database operating system developed by NASA to support rotorcraft flight tests, is described. Capabilities and characteristics of the system are presented, with examples of its use in recalling and analyzing rotorcraft flight-test data from a TRENDS database. The importance of system user-friendliness in gaining users' acceptance is stressed, as is the importance of integrating supporting narrative data with numerical data in engineering-test databases. Considerations relevant to the creation and maintenance of flight-test database are discussed and TRENDS' solutions to database management problems are described. Requirements, constraints, and other considerations which led to the system's configuration are discussed and some of the lessons learned during TRENDS' development are presented. Potential applications of TRENDS to a wide range of aeronautical and other engineering tests are identified.

[Historical succour of poverty and medical assistance in rural China.].

PubMed

Chen, Wen-Xian; Li, Ning-Xiu; Ren, Xiao-Hui

2009-11-01

There was considerable attention paid to the succour of poverty with widespread practice in China's history. Succour of poverty and medical assistance in rural areas were closely connected with famine relief carried out by the rulers. The mutual assistance of emotional and moral support long-term in rural communities is the most important form of medical assistance. A succour of poverty and medical assistance system in the modern sense should inherit and learn from the past consideration of poverty assistance and bring in the fine tradition of multiple forces to participate, in order to establish a succour of poverty and medical assistance system compatible with economic and social development. This is not only an important component of anti-poverty strategy in rural areas but also an inevitable requirement of historical development.

Dual Fan Separator within the Universal Waste Management System

NASA Technical Reports Server (NTRS)

Stapleton, Tom; Converse, Dave; Broyan, James Lee, Jr.

2014-01-01

Since NASA's new spacecraft in development for both LEO and Deep Space capability have considerable crew volume reduction in comparison to the Space Shuttle, it is clear that NASA requires a smaller and less expensive commode. The UTAS Universal Waste Management System (UWMS) was designed to address these new constraints, resulting in an 80% volume reduction in the cabin while enhancing performance. Whereas all of the current space commodes use air flow to capture both urine and feces and separate air from the captured air/urine mixture, the UWMS commode and urine fans and the urine separator were combined into a single unit. This unit enables use of a single motor and motor controller, which provides considerable packaging and weight efficiency. In some of the intended platform applications for the UWMS, the urine is pumped to a water reclamation system. The ISS Urine Processor Assembly (UPA) system requires delivered urine to include less than 0.25% air inclusion. Air inclusion in centrifugal urine separators is greatly dependent on its rotational speed. To satisfy this requirement, a gear reducer was included, allowing the fans to rotate at a much higher speed than the separator. This new design, the Dual Fan Separator (DFS) has been designed, prototyped and tested. This paper will outline the studies and analysis performed to develop the design configuration for testing. The studies included a configuration trade study, dynamic stability analysis of the rotating bodies and a performance analysis of included labyrinth seals. NASA is considereing a program to fly the UWMS aboard the ISS as a flight experiment. The goal of the design activity is to elevate the Technical Readiness Level (TRL) of the Dual Fan Separator and determine if the concept is ready to be included in flight experiment deliverable.

SSTO vs TSTO design considerations—an assessment of the overall performance, design considerations, technologies, costs, and sensitivities of SSTO and TSTO designs using modern technologies

NASA Astrophysics Data System (ADS)

Penn, Jay P.

1996-03-01

It is generally believed by those skilled in launch system design that Single-Stage-To-Orbit (SSTO) designs are more technically challenging, more performance sensitive, and yield larger lift-off weights than do Two-Stage-To-Orbit designs (TSTO's) offering similar payload delivery capability. Without additional insight into the other considerations which drive the development, recurring costs, operability, and reliability of a launch fleet, an analyst may easily conclude that the higher performing, less sensitive TSTO designs, thus yield a better solution to achieving low cost payload delivery. This limited insight could justify an argument to eliminate the X-33 SSTO technology/demonstration development effort, and thus proceed directly to less risky TSTO designs. Insight into real world design considerations of launch vehicles makes the choice of SSTO vs TSTO much less clear. The presentation addresses a more comprehensive evaluation of the general class of SSTO and TSTO concepts. These include pure SSTO's, augmented SSTO's, Siamese Twin, and Pure TSTO designs. The assessment considers vehicle performance and scaling relationships which characterize real vehicle designs. The assessment also addresses technology requirements, operations and supportability, cost implications, and sensitivities. Results of the assessment indicate that the trade space between various SSTO and TSTO design approaches is complex and not yet fully understood. The results of the X-33 technology demonstrators, as well as additional parametric analysis is required to better define the relative performance and costs of the various design approaches. The results also indicate that with modern technologies and today's better understanding of vehicle design considerations, the perception that SSTO's are dramatically heavier and more sensitive than TSTO designs is more of a myth, than reality.

Gene Knockdown of Venezuelan Equine Encephalitis Virus E2 Glycoprotein Using DNA-Directed RNA Interference

DTIC Science & Technology

2006-12-01

Defence Research and Recherche et developpement Development Canada pour la defense Canada DEFENCE r/sYDEFENSE Gene Knockdown of Venezuelan Equine...Further research is required to develop an antiviral against VEE that is both safe and effective. One antiviral strategy that has shown considerable...Novagen, Madison, WI)) on a MJ Research PTC-200 DNA engine (Bio-Rad, formerly MJ Research , Mississauga, ON). Amplification products (5 pL) were

CCIR for Complex and Uncertain Environments

DTIC Science & Technology

2007-05-01

these purposes. Doctrine gives such a wide variety of reasons for using CCIR that the concept seems unfocused, giving the commander no true criteria...complex. The true effect that these issues have on CCIR is open to a considerable amount of debate. Every commander has the freedom to develop his...operations. He set a precedent that seems to have held true through the entire history of intelligence requirements – every step in the development

Study of application of space telescope science operations software for SIRTF use

NASA Technical Reports Server (NTRS)

Dignam, F.; Stetson, E.; Allendoerfer, W.

1985-01-01

The design and development of the Space Telescope Science Operations Ground System (ST SOGS) was evaluated to compile a history of lessons learned that would benefit NASA's Space Infrared Telescope Facility (SIRTF). Forty-nine specific recommendations resulted and were categorized as follows: (1) requirements: a discussion of the content, timeliness and proper allocation of the system and segment requirements and the resulting impact on SOGS development; (2) science instruments: a consideration of the impact of the Science Instrument design and data streams on SOGS software; and (3) contract phasing: an analysis of the impact of beginning the various ST program segments at different times. Approximately half of the software design and source code might be useable for SIRTF. Transportability of this software requires, at minimum, a compatible DEC VAX-based architecture and VMS operating system, system support software similar to that developed for SOGS, and continued evolution of the SIRTF operations concept and requirements such that they remain compatible with ST SOGS operation.

Clinical Trials Targeting Aging and Age-Related Multimorbidity

PubMed Central

Crimmins, Eileen M; Grossardt, Brandon R; Crandall, Jill P; Gelfond, Jonathan A L; Harris, Tamara B; Kritchevsky, Stephen B; Manson, JoAnn E; Robinson, Jennifer G; Rocca, Walter A; Temprosa, Marinella; Thomas, Fridtjof; Wallace, Robert; Barzilai, Nir

2017-01-01

Abstract Background There is growing interest in identifying interventions that may increase health span by targeting biological processes underlying aging. The design of efficient and rigorous clinical trials to assess these interventions requires careful consideration of eligibility criteria, outcomes, sample size, and monitoring plans. Methods Experienced geriatrics researchers and clinical trialists collaborated to provide advice on clinical trial design. Results Outcomes based on the accumulation and incidence of age-related chronic diseases are attractive for clinical trials targeting aging. Accumulation and incidence rates of multimorbidity outcomes were developed by selecting at-risk subsets of individuals from three large cohort studies of older individuals. These provide representative benchmark data for decisions on eligibility, duration, and assessment protocols. Monitoring rules should be sensitive to targeting aging-related, rather than disease-specific, outcomes. Conclusions Clinical trials targeting aging are feasible, but require careful design consideration and monitoring rules. PMID:28364543

Human subjects concerns in ground based ECLSS testing - Managing uncertainty in closely recycled systems

NASA Technical Reports Server (NTRS)

Crump, William J.; Janik, Daniel S.; Thomas, L. Dale

1990-01-01

U.S. space missions have to this point used water either made on board or carried from earth and discarded after use. For Space Station Freedom, long duration life support will include air and water recycling using a series of physical-chemical subsystems. The Environmental Control and Life Support System (ECLSS) designed for this application must be tested extensively at all stages of hardware maturity. Human test subjects are required to conduct some of these tests, and the risks associated with the use of development hardware must be addressed. Federal guidelines for protection of human subjects require careful consideration of risks and potential benefits by an Institutional Review Board (IRB) before and during testing. This paper reviews the ethical principles guiding this consideration, details the problems and uncertainties inherent in current hardware testing, and presents an incremental approach to risk assessment for ECLSS testing.

Laser power beaming applications and technology

NASA Astrophysics Data System (ADS)

Burke, Robert J.; Cover, Ralph A.; Curtin, Mark S.; Dinius, R.; Lampel, Michael C.

1994-05-01

Beaming laser energy to spacecraft has important economic potential. It promises significant reduction in the cost of access to space, for commercial and government missions. While the potential payoff is attractive, existing technologies perform the same missions and the keys to market penetration for power beaming are a competitive cost and a schedule consistent with customers' plans. Rocketdyne is considering these questions in the context of a commercial enterprise -- thus, evaluation of the requirements must be done based on market assessments and recognition that significant private funding will be involved. It is in the context of top level business considerations that the technology requirements are being assessed and the program being designed. These considerations result in the essential elements of the development program. Since the free electron laser is regarded as the `long pole in the tent,' this paper summarizes Rocketdyne's approach for a timely, cost-effective program to demonstrate an FEL capable of supporting an initial operating capability.

Fast algorithms for Quadrature by Expansion I: Globally valid expansions

NASA Astrophysics Data System (ADS)

Rachh, Manas; Klöckner, Andreas; O'Neil, Michael

2017-09-01

The use of integral equation methods for the efficient numerical solution of PDE boundary value problems requires two main tools: quadrature rules for the evaluation of layer potential integral operators with singular kernels, and fast algorithms for solving the resulting dense linear systems. Classically, these tools were developed separately. In this work, we present a unified numerical scheme based on coupling Quadrature by Expansion, a recent quadrature method, to a customized Fast Multipole Method (FMM) for the Helmholtz equation in two dimensions. The method allows the evaluation of layer potentials in linear-time complexity, anywhere in space, with a uniform, user-chosen level of accuracy as a black-box computational method. Providing this capability requires geometric and algorithmic considerations beyond the needs of standard FMMs as well as careful consideration of the accuracy of multipole translations. We illustrate the speed and accuracy of our method with various numerical examples.

Data inversion algorithm development for the hologen occultation experiment

NASA Technical Reports Server (NTRS)

Gordley, Larry L.; Mlynczak, Martin G.

1986-01-01

The successful retrieval of atmospheric parameters from radiometric measurement requires not only the ability to do ideal radiometric calculations, but also a detailed understanding of instrument characteristics. Therefore a considerable amount of time was spent in instrument characterization in the form of test data analysis and mathematical formulation. Analyses of solar-to-reference interference (electrical cross-talk), detector nonuniformity, instrument balance error, electronic filter time-constants and noise character were conducted. A second area of effort was the development of techniques for the ideal radiometric calculations required for the Halogen Occultation Experiment (HALOE) data reduction. The computer code for these calculations must be extremely complex and fast. A scheme for meeting these requirements was defined and the algorithms needed form implementation are currently under development. A third area of work included consulting on the implementation of the Emissivity Growth Approximation (EGA) method of absorption calculation into a HALOE broadband radiometer channel retrieval algorithm.

Environmental requirements for flat plate photovoltaic modules for terrestrial applications

NASA Technical Reports Server (NTRS)

Hoffman, A. R.; Ross, R. G., Jr.

1979-01-01

The environmental test requirements that have been developed for flat plate modules purchased through Department of Energy funding are described. Concurrent with the selection of the initial qualification tests from space program experience - temperature cycling and humidity - surveys of existing photovoltaic systems in the field revealed that arrays were experiencing the following failure modes: interconnect breakage, delamination, and electrical termination corrosion. These coupled with application-dependent considerations led to the development of additional qualification tests, such as cyclic pressure loading, warped mounting surface, and hail. Rationale for the selection of tests, their levels and durations is described. Comparisons between field-observed degradation and test-induced degradation show a positive correlation with some of the observed field effects. Also, the tests are proving useful for detecting design, process, and workmanship deficiencies. The status of study efforts for the development of environmental requirements for field-related problems is reviewed.

Xenon lighting adjusted to plant requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koefferlein, M.; Doehring, T.; Payer, H.D.

1994-12-31

The high luminous flux and spectral properties of xenon lamps would provide an ideal luminary for plant lighting if not excess IR radiation poses several problems for an application: the required filter systems reduce the irradiance at spectral regions of particular importance for plant development. Most of the economical drawbacks of xenon lamps are related to the difficult handling of that excess IR energy. Furthermore, the temporal variation of the xenon output depending on the oscillations of the applied AC voltage has to be considered for the plant development. However, xenon lamps outperform other lighting systems with respect to spectralmore » stability, immediate response, and maximum luminance. Therefore, despite considerable competition by other lighting techniques, xenon lamps provide a very useful tool for special purposes. In plant lighting however, they seem to play a less important role as other lamp and lighting developments can meet these particular requirements at lower costs.« less

A Flight Deck Decision Support Tool for Autonomous Airborne Operations

NASA Technical Reports Server (NTRS)

Ballin, Mark G.; Sharma, Vivek; Vivona, Robert A.; Johnson, Edward J.; Ramiscal, Ermin

2002-01-01

NASA is developing a flight deck decision support tool to support research into autonomous operations in a future distributed air/ground traffic management environment. This interactive real-time decision aid, referred to as the Autonomous Operations Planner (AOP), will enable the flight crew to plan autonomously in the presence of dense traffic and complex flight management constraints. In assisting the flight crew, the AOP accounts for traffic flow management and airspace constraints, schedule requirements, weather hazards, aircraft operational limits, and crew or airline flight-planning goals. This paper describes the AOP and presents an overview of functional and implementation design considerations required for its development. Required AOP functionality is described, its application in autonomous operations research is discussed, and a prototype software architecture for the AOP is presented.

The EVA space suit development in Europe.

PubMed

Skoog, A I

1994-01-01

The progress of the European EVA space suit predevelopment activities has resulted in an improved technical reference concept, which will form the basis for a start of the Phase C/D development work in 1992. Technology development work over the last 2 years has resulted in a considerable amount of test data and a better understanding of the characteristics and behaviour of individual parts of the space suit system, in particular in the areas of suits' mobility and life support functions. This information has enabled a consolidation of certain design features on the one hand, but also led to the challenging of some of the design solutions on the other hand. While working towards an improved situation with respect to the main design drivers mass and cost, the technical concept has been improved with respect to functional safety and ease of handling, taking the evolving Hermes spaceplane requirements into consideration. Necessary hardware and functional redundancies have been implemented taking the operational scenario with Hermes and Columbus servicing into consideration. This paper presents the latest design status of the European EVA space suit concept, with particular emphasis on crew safety, comfort and productivity, in the frame of the predevelopment work for the European Space Agency.

Cost/Effort Drivers and Decision Analysis

NASA Technical Reports Server (NTRS)

Seidel, Jonathan

2010-01-01

Engineering trade study analyses demand consideration of performance, cost and schedule impacts across the spectrum of alternative concepts and in direct reference to product requirements. Prior to detailed design, requirements are too often ill-defined (only goals ) and prone to creep, extending well beyond the Systems Requirements Review. Though lack of engineering design and definitive requirements inhibit the ability to perform detailed cost analyses, affordability trades still comprise the foundation of these future product decisions and must evolve in concert. This presentation excerpts results of the recent NASA subsonic Engine Concept Study for an Advanced Single Aisle Transport to demonstrate an affordability evaluation of performance characteristics and the subsequent impacts on engine architecture decisions. Applying the Process Based Economic Analysis Tool (PBEAT), development cost, production cost, as well as operation and support costs were considered in a traditional weighted ranking of the following system-level figures of merit: mission fuel burn, take-off noise, NOx emissions, and cruise speed. Weighting factors were varied to ascertain the architecture ranking sensitivities to these performance figures of merit with companion cost considerations. A more detailed examination of supersonic variable cycle engine cost is also briefly presented, with observations and recommendations for further refinements.

An exploration of multilevel modeling for estimating access to drinking-water and sanitation.

PubMed

Wolf, Jennyfer; Bonjour, Sophie; Prüss-Ustün, Annette

2013-03-01

Monitoring progress towards the targets for access to safe drinking-water and sanitation under the Millennium Development Goals (MDG) requires reliable estimates and indicators. We analyzed trends and reviewed current indicators used for those targets. We developed continuous time series for 1990 to 2015 for access to improved drinking-water sources and improved sanitation facilities by country using multilevel modeling (MLM). We show that MLM is a reliable and transparent tool with many advantages over alternative approaches to estimate access to facilities. Using current indicators, the MDG target for water would be met, but the target for sanitation missed considerably. The number of people without access to such services is still increasing in certain regions. Striking differences persist between urban and rural areas. Consideration of water quality and different classification of shared sanitation facilities would, however, alter estimates considerably. To achieve improved monitoring we propose: (1) considering the use of MLM as an alternative for estimating access to safe drinking-water and sanitation; (2) completing regular assessments of water quality and supporting the development of national regulatory frameworks as part of capacity development; (3) evaluating health impacts of shared sanitation; (4) using a more equitable presentation of countries' performances in providing improved services.

Evolution of the INMARSAT aeronautical system: Service, system, and business considerations

NASA Technical Reports Server (NTRS)

Sengupta, Jay R.

1995-01-01

A market-driven approach was adopted to develop enhancements to the Inmarsat-Aeronautical system, to address the requirements of potential new market segments. An evolutionary approach and well differentiated product/service portfolio was required, to minimize system upgrade costs and market penetration, respectively. The evolved system definition serves to minimize equipment cost/size/mass for short/medium range aircraft, by reducing the antenna gain requirement and relaxing the performance requirements for non safety-related communications. A validation program involving simulation, laboratory tests, over-satellite tests and flight trials is being conducted to confirm the system definition. Extensive market research has been conducted to determine user requirements and to quantify market demand for future Inmarsat Aero-1 AES, using sophisticated computer assisted survey techniques.

The requirements for implementing Sustainable Development Goals (SDGs) and for planning and implementing Integrated Territorial Investments (ITI) in mining areas

NASA Astrophysics Data System (ADS)

Florkowska, Lucyna; Bryt-Nitarska, Izabela

2018-04-01

The notion of Integrated Territorial Investments (ITI) appears more and more frequently in contemporary regional development strategies. Formulating the main assumptions of ITI is a response to a growing need for a co-ordinated, multi-dimensional regional development suitable for the characteristics of a given area. Activities are mainly aimed at improving people's quality of life with their significant participation. These activities include implementing the Sustainable development Goals (SDGs). Territorial investments include, among others, projects in areas where land and building use is governed not only by general regulations (Spatial Planning and Land Development Act) but also by separate legal acts. This issue also concerns areas with active mines and post-mining areas undergoing revitalization. For the areas specified above land development and in particular making building investments is subject to the requirements set forth in the Geological and Mining Law and in the general regulations. In practice this means that factors connected with the present and future mining impacts must be taken into consideration in planning the investment process. This article discusses the role of proper assessment of local geological conditions as well as the current and future mining situation in the context of proper planning and performance of the Integrated Territorial Investment programme and also in the context of implementing the SDGs. It also describes the technical and legislative factors which need to be taken into consideration in areas where mining is planned or where it took place in the past.

Nuclear energy center site survey reactor plant considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harty, H.

The Energy Reorganization Act of 1974 required the Nuclear Regulatory Commission (NRC) to make a nuclear energy center site survey (NECSS). Background information for the NECSS report was developed in a series of tasks which include: socioeconomic inpacts; environmental impact (reactor facilities); emergency response capability (reactor facilities); aging of nuclear energy centers; and dry cooled nuclear energy centers.

Work-Based Learning: Learning To Work; Working To Learn; Learning To Learn.

ERIC Educational Resources Information Center

Strumpf, Lori; Mains, Kristine

This document describes a work-based learning approach designed to integrate work and learning at the workplace and thereby help young people develop the skills required for changing workplaces. The following considerations in designing work-based programs are discussed: the trend toward high performance workplaces and changes in the way work is…

Forum Guide to Facilities Information Management: A Resource for State and Local Education Agencies. NFES 2012-808

ERIC Educational Resources Information Center

National Forum on Education Statistics, 2012

2012-01-01

Safe and secure facilities that foster learning are crucial to providing quality education services, and developing and maintaining these facilities requires considerable resources and organization. Facility information systems allow education organizations to collect and manage data that can be used to inform and guide decisionmaking about the…

UH-1 Helicopter Mechanic (MOS 67N20) Job Description Survey: Background, Training, and General Maintenance Activities.

ERIC Educational Resources Information Center

Schulz, Russel E.; And Others

The report, the first of two documents examining the relationship among job requirements, training, and manpower considerations for Army aviation maintenance Personnel, discusses the development of task data gathering techniques and procedures for incorporating this data into training programs for the UH-1 helicopter mechanic sPecialty (MOS…

24 CFR 15.204 - Consideration of demands for production of material or provision of testimony.

Code of Federal Regulations, 2010 CFR

2010-04-01

... unreasonable; (vii) Production of the material or provision of the testimony would not be required under the... production of material or provision of testimony. 15.204 Section 15.204 Housing and Urban Development Office... FREEDOM OF INFORMATION ACT AND TESTIMONY AND PRODUCTION OF INFORMATION BY HUD EMPLOYEES Production of...

Operations and Maintenance December Newsletter | Poster

Cancer.gov

Our first consideration in every task, large or small, is the safety of our O&M work force and our customers. You, our customer, play an important role in the execution of your work order. The support you provide assists us in understanding the work order requirements, which is the first step in developing a safe plan for accomplishing your request.

A Neuroimaging Proof of Principle Study of Down's Syndrome and Dementia: Ethical and Methodological Challenges in Intrusive Research

ERIC Educational Resources Information Center

d'Abrera, J. C.; Holland, A. J.; Landt, J.; Stocks-Gee, G.; Zaman, S. H.

2013-01-01

Background: Research into specific illnesses and the development of new treatments may only become possible as new technologies become available. When used for research, such technologies may best be described as "intrusive", in that they require a considerable willingness and commitment on the part of the participants. This has…

Underestimating risks to the northern spotted owl in fire-prone forests: response to Hanson et al

Treesearch

Thomas A. Spies; Jay D. Miller; Joseph B. Buchanan; John F. Lehmkuhl; Jerry F. Franklin; Sean P. Healey; Paul F. Hessburg; Hugh D. Safford; Warren B. Cohen; Rebecca S.H. Kennedy; Eric E. Knapp; James K. Agee; Melinda Moeur

2010-01-01

The development of conservation plans for Northern Spotted Owls (NSO) (Strix occidentalis caurina) in disturbance-prone landscapes requires evaluation of multiple threats and careful consideration of the consequences of management actions intended to reduce risk. Hanson et al. (2009) used downwardly revised estimates of recent old-forest losses to...

Are You Ready to Assess Social and Emotional Development? SEL Solutions Tools Index

ERIC Educational Resources Information Center

American Institutes for Research, 2015

2015-01-01

Assessing individuals' social and emotional (SE) knowledge, attitudes, and skills is a complex task. It requires careful consideration of the assessment purpose, rigor, practicality, burden, and ethics. Once you have considered these factors and have determined that you are, in fact, "Ready to Assess," you are ready to act and choose an…

23 CFR Appendix C to Subpart B of... - Additional Required Contract Provisions, Appalachian Development Highway System and Local Access...

Code of Federal Regulations, 2014 CFR

2014-04-01

... for employment because of race, color, sex, or national origin. The contractor will take affirmative... regard to their race, color, sex, or national origin. Such action shall include, but not be limited to... receive consideration for employment without regard to race, color, sex, or national origin. c. The...

23 CFR Appendix C to Subpart B of... - Additional Required Contract Provisions, Appalachian Development Highway System and Local Access...

Code of Federal Regulations, 2011 CFR

2011-04-01

... for employment because of race, color, sex, or national origin. The contractor will take affirmative... regard to their race, color, sex, or national origin. Such action shall include, but not be limited to... receive consideration for employment without regard to race, color, sex, or national origin. c. The...

23 CFR Appendix C to Subpart B of... - Additional Required Contract Provisions, Appalachian Development Highway System and Local Access...

Code of Federal Regulations, 2013 CFR

2013-04-01

... for employment because of race, color, sex, or national origin. The contractor will take affirmative... regard to their race, color, sex, or national origin. Such action shall include, but not be limited to... receive consideration for employment without regard to race, color, sex, or national origin. c. The...

Point source detection in infrared astronomical surveys

NASA Technical Reports Server (NTRS)

Pelzmann, R. F., Jr.

1977-01-01

Data processing techniques useful for infrared astronomy data analysis systems are reported. This investigation is restricted to consideration of data from space-based telescope systems operating as survey instruments. In this report the theoretical background for specific point-source detection schemes is completed, and the development of specific algorithms and software for the broad range of requirements is begun.

Factors influencing line officers' decisions about National Environmental Policy Act project design and development.

Treesearch

Donald G. MacGregor; David N. Seesholtz

2008-01-01

Prior to the existence of the National Environmental Policy Act (NEPA), Forest Service district rangers had considerable latitude to make resource management decisions and execute management plans with relatively little encumbrance by documentation and process requirements. Today there appear to be differences not only in the district ranger population, but in the...

Abuses and Mysteries at the Association of Social Work Boards

ERIC Educational Resources Information Center

Woodcock, Ray

2016-01-01

Under contract with the Association of Social Work Boards (ASWB), Pearson VUE reportedly performs much of the work of developing and administering the social work licensing exams required by most states. ASWB charges substantial fees for such exams and, after paying Pearson, has been able to bank considerable sums. One of the key contributions to…

Getting my child to eat the right amount. Mothers' considerations when deciding how much food to offer their child at a meal

USDA-ARS?s Scientific Manuscript database

Feeding young children successfully requires parenting skills,trust that children will eat, and nutrition and child development knowledge to ensure that foods and the amounts offered are developmentally appropriate. Mothers are often responsible for determining how much food is offered to their chil...

Developing Market Opportunities for Flexible Rooftop Applications of PV Using Flexible CIGS Technology: Market Considerations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sabnani, L.; Skumanich, A.; Ryabova, E.

There has been a recent upsurge in developments for building-integrated phototovoltaics (BiPV) roof top materials based on CIGS. Several new companies have increased their presence and are looking to bring products to market for this application in 2011. For roof-top application, there are significant key requirements beyond just having good conversion efficiency. Other attributes include lightweight, as well as moisture-proof, and fully functionally reliable. The companies bringing these new BIPV/BAPV products need to ensure functionality with a rigorous series of tests, and have an extensive set of 'torture' tests to validate the capability. There is a convergence of form, aesthetics,more » and physics to ensure that the CIGS BiPV deliver on their promises. This article will cover the developments in this segment of the BiPV market and delve into the specific tests and measurements needed to characterize the products. The potential market sizes are evaluated and the technical considerations developed.« less

Development of a large scale bipolar NiH2 battery

NASA Technical Reports Server (NTRS)

Adler, E.; Perez, F.

1983-01-01

The bipolar battery concept, developed in cooperation with NASA, is described in the context of the advantages afforded by near-term IPV and CVP cell technology. The projected performance, development requirements, and a possible approach to bipolar battery design are outlined. Consideration is given to packaging electrodes within a common hydrophobic plastic frame, electrode technology that involves a photochemically etched 0.1 mm thick nickel substrate coated with a 10 mg/sq cm mixture of platinum powder and TFE30, and an electrode design that eliminates the screen and doubles the electrode thickness (from the currently used 0.8 mm) while retaining the active material loading of 1.6-1.8 gm/cu cm. Also covered are thermal management, and electrolyte and oxygen management. It is concluded that a high voltage, high capacity, bipolar NiH2 cell can be configured with proper development for use in large power systems, and that it can provide considerable weight savings.

Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database--UNC GOLD.

PubMed

Gallagher, Sarah A; Smith, Angela B; Matthews, Jonathan E; Potter, Clarence W; Woods, Michael E; Raynor, Mathew; Wallen, Eric M; Rathmell, W Kimryn; Whang, Young E; Kim, William Y; Godley, Paul A; Chen, Ronald C; Wang, Andrew; You, Chaochen; Barocas, Daniel A; Pruthi, Raj S; Nielsen, Matthew E; Milowsky, Matthew I

2014-01-01

The management of genitourinary malignancies requires a multidisciplinary care team composed of urologists, medical oncologists, and radiation oncologists. A genitourinary (GU) oncology clinical database is an invaluable resource for patient care and research. Although electronic medical records provide a single web-based record used for clinical care, billing, and scheduling, information is typically stored in a discipline-specific manner and data extraction is often not applicable to a research setting. A GU oncology database may be used for the development of multidisciplinary treatment plans, analysis of disease-specific practice patterns, and identification of patients for research studies. Despite the potential utility, there are many important considerations that must be addressed when developing and implementing a discipline-specific database. The creation of the GU oncology database including prostate, bladder, and kidney cancers with the identification of necessary variables was facilitated by meetings of stakeholders in medical oncology, urology, and radiation oncology at the University of North Carolina (UNC) at Chapel Hill with a template data dictionary provided by the Department of Urologic Surgery at Vanderbilt University Medical Center. Utilizing Research Electronic Data Capture (REDCap, version 4.14.5), the UNC Genitourinary OncoLogy Database (UNC GOLD) was designed and implemented. The process of designing and implementing a discipline-specific clinical database requires many important considerations. The primary consideration is determining the relationship between the database and the Institutional Review Board (IRB) given the potential applications for both clinical and research uses. Several other necessary steps include ensuring information technology security and federal regulation compliance; determination of a core complete dataset; creation of standard operating procedures; standardizing entry of free text fields; use of data exports, queries, and de-identification strategies; inclusion of individual investigators' data; and strategies for prioritizing specific projects and data entry. A discipline-specific database requires a buy-in from all stakeholders, meticulous development, and data entry resources to generate a unique platform for housing information that may be used for clinical care and research with IRB approval. The steps and issues identified in the development of UNC GOLD provide a process map for others interested in developing a GU oncology database. Copyright © 2014 Elsevier Inc. All rights reserved.

Analysis of mutual assured destruction-like scenario with swarms of non-recallable autonomous robots

NASA Astrophysics Data System (ADS)

Straub, Jeremy

2015-05-01

This paper considers the implications of the creation of an autonomous robotic fighting force without recall-ability which could serve as a deterrent to a `total war' magnitude attack. It discusses the technical considerations for this type of robotic system and the limited enhancements required to current technologies (particularly UAVs) needed to create such a system. Particular consideration is paid to how the introduction of this type of technology by one actor could create a need for reciprocal development. Also considered is the prospective utilization of this type of technology by non-state actors and the impact of this on state actors.

Electrodynamic tethers for energy conversion

NASA Technical Reports Server (NTRS)

Nobles, W.

1986-01-01

Conductive tethers have been proposed as a new method for converting orbital mechanical energy into electrical power for use on-board a satellite (generator mode) or conversely (motor mode) as a method of providing electric propulsion using electrical energy from the satellite. The operating characteristics of such systems are functionally dependent on orbit altitude and inclination. Effects of these relationships are examined to determine acceptable regions of application. To identify system design considerations, a specific set of system performance goals and requirements are selected. The case selected is for a 25 kW auxiliary power system for use on Space Station. Appropriate system design considerations are developed, and the resulting system is described.

Shared mission operations concept

NASA Technical Reports Server (NTRS)

Spradlin, Gary L.; Rudd, Richard P.; Linick, Susan H.

1994-01-01

Historically, new JPL flight projects have developed a Mission Operations System (MOS) as unique as their spacecraft, and have utilized a mission-dedicated staff to monitor and control the spacecraft through the MOS. NASA budgetary pressures to reduce mission operations costs have led to the development and reliance on multimission ground system capabilities. The use of these multimission capabilities has not eliminated an ongoing requirement for a nucleus of personnel familiar with a given spacecraft and its mission to perform mission-dedicated operations. The high cost of skilled personnel required to support projects with diverse mission objectives has the potential for significant reduction through shared mission operations among mission-compatible projects. Shared mission operations are feasible if: (1) the missions do not conflict with one another in terms of peak activity periods, (2) a unique MOS is not required, and (3) there is sufficient similarity in the mission profiles so that greatly different skills would not be required to support each mission. This paper will further develop this shared mission operations concept. We will illustrate how a Discovery-class mission would enter a 'partner' relationship with the Voyager Project, and can minimize MOS development and operations costs by early and careful consideration of mission operations requirements.

77 FR 29345 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-17

... of the Currency), Director Richard Cordray (Director, Consumer Financial Protection Bureau) and Acting Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters... earlier notice of the meeting was practicable; that the public interest did not require consideration of...

NACS Store Planning Manual.

ERIC Educational Resources Information Center

College Store Journal, 1979

1979-01-01

Topics discussed by the NACS Store Planning/Renovation Committees in this updated version of the college store renovation manual include: short- and long-range planning, financial considerations, professional planning assistance, the store's image and business character, location considerations, building requirements, space requirements, fixtures,…

IMPACTS OF IMAGERY TEMPORAL FREQUENCES ON LAND-COVER CHANGE DETECTION MONITORING

EPA Science Inventory

An important consideration for monitoring land~cover (LC) change is the nominal temporal frequency of remote sensor data acquisitions required to adequately characterize change events, Ecosystem specific regeneration rates are an important consideration for determining the requir...

Land-Use Intensity of Electricity Production: Comparison Across Multiple Sources

NASA Astrophysics Data System (ADS)

Swain, M.; Lovering, J.; Blomqvist, L.; Nordhaus, T.; Hernandez, R. R.

2015-12-01

Land is an increasingly scarce global resource that is subject to competing pressures from agriculture, human settlement, and energy development. As countries concerned about climate change seek to decarbonize their power sectors, renewable energy sources like wind and solar offer obvious advantages. However, the land needed for new energy infrastructure is also an important environmental consideration. The land requirement of different electricity sources varies considerably, but there are very few studies that offer a normalized comparison. In this paper, we use meta-analysis to calculate the land-use intensity (LUI) of the following electricity generation sources: wind, solar photovoltaic (PV), concentrated solar power (CSP), hydropower, geothermal, nuclear, biomass, natural gas, and coal. We used data from existing studies as well as original data gathered from public records and geospatial analysis. Our land-use metric includes land needed for the generation facility (e.g., power plant or wind farm) as well as the area needed to mine fuel for natural gas, coal, and nuclear power plants. Our results found the lowest total LUI for nuclear power (115 ha/TWh/y) and the highest LUI for biomass (114,817 ha/TWh/y). Solar PV and CSP had a considerably lower LUI than wind power, but both were an order of magnitude higher than fossil fuels (which ranged from 435 ha/TWh/y for natural gas to 579 ha/TWh/y for coal). Our results suggest that a large build-out of renewable electricity, though it would offer many environmental advantages over fossil fuel power sources, would require considerable land area. Among low-carbon energy sources, relatively compact sources like nuclear and solar have the potential to reduce land requirements.

48 CFR 32.005 - Consideration for contract financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Consideration for contract... GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 32.005 Consideration for contract financing. (a... separate consideration for the contract financing clause. The value of the contract financing to the...

Considerations for U.S. Policy Toward Conventional Arms Manufacturers in Post-Conflict or Failed-State Environments

DTIC Science & Technology

2014-06-13

article, Chivers highlights the “ development of local arms-producing industries in Syrian cities and the countryside,” claiming that given the absence...At the operational and tactical levels, military commanders and their staffs must develop a mindset where protection of critical infrastructure is...presented to the Faculty of the U.S. Army Command and General Staff College in partial fulfillment of the requirements for the degree MASTER OF

New luster for space robots and automation

NASA Technical Reports Server (NTRS)

Heer, E.

1978-01-01

Consideration is given to the potential role of robotics and automation in space transportation systems. Automation development requirements are defined for projects in space exploration, global services, space utilization, and space transport. In each category the potential automation of ground operations, on-board spacecraft operations, and in-space handling is noted. The major developments of space robot technology are noted for the 1967-1978 period. Economic aspects of ground-operation, ground command, and mission operations are noted.

Prioritization Methodology for Chemical Replacement

NASA Technical Reports Server (NTRS)

Cruit, W.; Schutzenhofer, S.; Goldberg, B.; Everhart, K.

1993-01-01

This project serves to define an appropriate methodology for effective prioritization of efforts required to develop replacement technologies mandated by imposed and forecast legislation. The methodology used is a semiquantitative approach derived from quality function deployment techniques (QFD Matrix). This methodology aims to weigh the full environmental, cost, safety, reliability, and programmatic implications of replacement technology development to allow appropriate identification of viable candidates and programmatic alternatives. The results are being implemented as a guideline for consideration for current NASA propulsion systems.

Poster — Thur Eve — 41: Considerations for Patients with Permanently Implant Radioactive Sources Requiring Unrelated Surgery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basran, P. S; Beckham, WA; Baxter, P

Permanent implant of sealed radioactive sources is an effective technique for treating cancer. Typically, the radioactive sources are implanted in and near the disease, depositing dose locally over several months. There may be instances where these patients must undergo unrelated surgical procedures when the radioactive material remains active enough to pose risks. This work explores these risks, discusses strategies to mitigate those risks, and describes a case study for a permanent I-125 prostate brachytherapy implant patient who developed colo-rectal cancer and required surgery 6 months after brachytherapy. The first consideration is identifying the risk from unwarranted radiation to the patientmore » and staff before, during, and after the surgical procedure. The second is identifying the risk the surgical procedure may have on the efficacy of the brachytherapy implant. Finally, there are considerations for controlling for radioactive substances from a regulatory perspective. After these risks are defined, strategies to mitigate those risks are considered. These strategies may include applying the concepts of ALARA, the use of protective equipment and developing a best practice strategy with the operating room team. We summarize this experience with some guidelines: If the surgical procedure is near (ex: 5 cm) of the implant; and, the surgical intervention may dislodge radioisotopes enough to compromise treatment or introduces radiation safety risks; and, the radioisotope has not sufficiently decayed to background levels; and, the surgery cannot be postponed, then a detailed analysis of risk is advised.« less

Organizing a Collaborative Development of Technological Design Requirements Using a Constructive Dialogue on Value Profiles: A Case in Automated Vehicle Development.

PubMed

Flipse, Steven M; Puylaert, Steven

2018-02-01

Following societal and policy pressures for responsible innovation, innovators are more and more expected to consider the broader socio-ethical context of their work, and more importantly, to integrate such considerations into their daily practices. This may require the involvement of 'outsiders' in innovation trajectories, including e.g. societal and governmental actors. However, methods on how to functionally organize such integration in light of responsible innovation have only recently started to emerge. We present an approach to do just that, in which we first develop value profiles of the involved actors, and second, design a workshop setting that allows innovators to develop design requirements in collaboration with representatives of parties that are not usually involved in such innovation design practices. Using a case study in automated vehicle development, we positively demonstrate the possibility and utility of our approach. We stress that in this study we wish to demonstrate the functionality of our developed method, and did not search for scientifically valid outcomes regarding this technical field.

Study to define an approach for developing a computer-based system capable of automatic, unattended assembly/disassembly of spacecraft, phase 1

NASA Technical Reports Server (NTRS)

Nevins, J. L.; Defazio, T. L.; Seltzer, D. S.; Whitney, D. E.

1981-01-01

The initial set of requirements for additional studies necessary to implement a space-borne, computer-based work system capable of achieving assembly, disassembly, repair, or maintenance in space were developed. The specific functions required of a work system to perform repair and maintenance were discussed. Tasks and relevant technologies were identified and delineated. The interaction of spacecraft design and technology options, including a consideration of the strategic issues of repair versus retrieval-replacement or destruction by removal were considered along with the design tradeoffs for accomplishing each of the options. A concept system design and its accompanying experiment or test plan were discussed.

78 FR 41928 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

... the Currency), Director Richard Cordray (Director, Consumer Financial Protection Bureau), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be... the meeting was practicable; that the public interest did not require consideration of the matters in...

78 FR 48678 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... the Currency), Director Richard Cordray (Director, Consumer Financial Protection Bureau), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be... the meeting was practicable; that the public interest did not require consideration of the matters in...

78 FR 75920 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-13

... the Currency), Director Richard Cordray (Director, Consumer Financial Protection Bureau), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be... the meeting was practicable; that the public interest did not require consideration of the matters in...

78 FR 34100 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

... the Currency), Director Richard Cordray (Director, Consumer Financial Protection Bureau), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be... the meeting was practicable; that the public interest did not require consideration of the matters in...

78 FR 31548 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

... Currency), Director Richard Cordray (Director, Consumer Financial Protection Bureau), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be the subject... was practicable; that the public interest did not require consideration of the matters in a meeting...

78 FR 66005 - Notice of Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-04

... of the Currency), Director Richard Cordray (Director, Consumer Financial Protection Bureau), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which... notice of the meeting was practicable; that the public interest did not require consideration of the...

Standard module approach to scanning requirements for second-generation airborne FLIRs

NASA Astrophysics Data System (ADS)

Ludwiszewski, Alan P.

1995-05-01

This paper examines the specification requirements for the development of standard module scanning components to be used in conjunction with SADA I and SADA II sensor arrays. System-level design considerations are presented to identify a selection of components that is consistent with optimum use of the SADA technology. A limited-rotation electromagnetic actuator, used in conjunction with an angular position sensor and a digital controller, is shown to have the necessary performance and flexibility to perform the frame scan function for a wide range of airborne systems. System level requirements and specifications for an optional interlace scan system are also provided.

Low-mass materials and vertex detector systems

DOE PAGES

Cooper, William E.

2014-01-01

Physics requirements set the material budget and the precision and stability necessary in low-mass vertex detector systems. Operational considerations, along with physics requirements, set the operating environment to be provided and determine the heat to be removed. Representative materials for fulfilling those requirements are described and properties of the materials are tabulated. A figure of merit is proposed to aid in material selection. Multi-layer structures are examined as a method to allow material to be used effectively, thereby reducing material contributions. Lastly, comments are made on future directions to be considered in using present materials effectively and in developing newmore » materials.« less

Phase 1 of the near term hybrid passenger vehicles development program. Appendix A: Mission analysis and performance specification studies, volume 1

NASA Technical Reports Server (NTRS)

Traversi, M.; Barbarek, L. A. C.

1979-01-01

Applicable data was categorized and processed according to vehicle usage and trip parameters with consideration of payload (cargo, people, size) and driving cycles. A mission that maximizes the fuel potential savings for the total 1985 vehicle fleet was selected. Mission requirements that have a bearing on conventional and hybrid vehicle performance and characteristics were identified and formulated and a reference ICE vehicle was selected that meets or exceeds all requirements while maintaining within applicable constraints. Specifications for vehicle performance were established based on mission requirements, mission related vehicle characteristics, and fuel consumption.

Engine design considerations for 2nd generation supersonic transports

NASA Technical Reports Server (NTRS)

Howlett, R. A.

1975-01-01

The environmental and economic goals projected for advanced supersonic transports will require revolutionary improvements in propulsion systems. Variable cycle engine concepts that incorporate unique components and advanced technologies show promise in meeting these goals. Pratt & Whitney Aircraft is conducting conceptual design studies of variable cycle engine concepts under NASA sponsorship. This paper reviews some of the design considerations for these engine concepts. Emphasis is placed on jet noise abatement, reduction of emissions, performance improvements, installation considerations, hot-section characteristics and control system requirements. Two representative variable cycle engine concepts that incorporate these basic design considerations are described.

VHA mental health information system: applying health information technology to monitor and facilitate implementation of VHA Uniform Mental Health Services Handbook requirements.

PubMed

Trafton, Jodie A; Greenberg, Greg; Harris, Alex H S; Tavakoli, Sara; Kearney, Lisa; McCarthy, John; Blow, Fredric; Hoff, Rani; Schohn, Mary

2013-03-01

To describe the design and deployment of health information technology to support implementation of mental health services policy requirements in the Veterans Health Administration (VHA). Using administrative and self-report survey data, we developed and fielded metrics regarding implementation of the requirements delineated in the VHA Uniform Mental Health Services Handbook. Finalized metrics were incorporated into 2 external facilitation-based quality improvement programs led by the VHA Mental Health Operations. To support these programs, tailored site-specific reports were generated. Metric development required close collaboration between program evaluators, policy makers and clinical leadership, and consideration of policy language and intent. Electronic reports supporting different purposes required distinct formatting and presentation features, despite their having similar general goals and using the same metrics. Health information technology can facilitate mental health policy implementation but must be integrated into a process of consensus building and close collaboration with policy makers, evaluators, and practitioners.

System description and analysis. Part 1: Feasibility study for helicopter/VTOL wide-angle simulation image generation display system

NASA Technical Reports Server (NTRS)

1977-01-01

A preliminary design for a helicopter/VSTOL wide angle simulator image generation display system is studied. The visual system is to become part of a simulator capability to support Army aviation systems research and development within the near term. As required for the Army to simulate a wide range of aircraft characteristics, versatility and ease of changing cockpit configurations were primary considerations of the study. Due to the Army's interest in low altitude flight and descents into and landing in constrained areas, particular emphasis is given to wide field of view, resolution, brightness, contrast, and color. The visual display study includes a preliminary design, demonstrated feasibility of advanced concepts, and a plan for subsequent detail design and development. Analysis and tradeoff considerations for various visual system elements are outlined and discussed.

Aerodynamic characteristics of the Fiat UNO car

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costelli, A.F.

1984-01-01

The purpose of this article is to describe the work conducted in the aerodynamic field throughout the 4-year development and engineering time span required by the project of the UNO car. A description is given of all the parametric studies carried out. Through these studies two types of cars at present in production were defined and the characteristics of a possible future sports version laid down. A movable device, to be fitted in the back window, was also set up and patented. When actuated it reduces soiling of back window. A description is also provided of the measurements made inmore » the car flow field and some considerations are outlined about the method applied. This method is still in development phase but it already permits some considerations and in-depth investigations to be made on the vehicle wake.« less

Considerations for an exercise prescription

NASA Technical Reports Server (NTRS)

Convertino, Victor A.

1989-01-01

A number of past and most recent research findings that describe some of the physiological responses to exercise in man and their relationship with exposure to various gravitational environments are discussed. Most of the data pertain to adaptations of the cardiovascular and body fluid systems. It should be kept in mind that the data from studies on microgravity simulation in man include exposures of relatively short duration (5 hours to 14 days). However, it is argued that the results may provide important guidelines for the consideration of many variables which are pertinent to the development of exercise prescription for long-duration space flight. The following considerations for exercise prescriptions during long-duration space flight are noted: (1) Relatively high aerobic fitness and strength, especially of the upper body musculature, should be a criterion for selection of astronauts who will be involved in EVA, since endurance and strength appear to be predominant characteristics for work performance. (2) Some degree of upper body strength will probably be required for effective performance of EVA. However, the endurance and strength required by the upper body for EVA can probably be obtained through preflight exercise prescription which involves swimming. (3) Although some degree of arm exercise may be required to maintain preflight endurance and strength, researchers propose that regular EVA will probably be sufficient to maintain the endurance and strength required to effectively perform work tasks during space flight. (4) A minimum of one maximal aerobic exercise every 7 to 10 days during space flight may be all that is necessary for maintenance of normal cardiovascular responsiveness and replacement of body fluids for reentry following prolonged space flight. (5) The possible reduction in the amount of exercise required for maintenance of cardiovascular system and body fluids in combination with the use of electromyostimulation (EMS) or methods other than conventional exercise for maintaining size and strength of muscles and bones needs great consideration for further research. These approaches represent a potential solution to the problem of compromising valuable time for exercise that is needed for daily operations.

Manned space flight nuclear system safety. Volume 5: Nuclear System safety guidelines. Part 1: Space base nuclear safety

NASA Technical Reports Server (NTRS)

1972-01-01

The design and operations guidelines and requirements developed in the study of space base nuclear system safety are presented. Guidelines and requirements are presented for the space base subsystems, nuclear hardware (reactor, isotope sources, dynamic generator equipment), experiments, interfacing vehicles, ground support systems, range safety and facilities. Cross indices and references are provided which relate guidelines to each other, and to substantiating data in other volumes. The guidelines are intended for the implementation of nuclear safety related design and operational considerations in future space programs.

Manned space flight nuclear system safety. Voluem 5: Nuclear system safety guidelines. Part 2: Space shuttle/nuclear payloads safety

NASA Technical Reports Server (NTRS)

1972-01-01

The design and operations guidelines and requirements developed in the study of space shuttle nuclear system transportation are presented. Guidelines and requirements are presented for the shuttle, nuclear payloads (reactor, isotope-Brayton and small isotope sources), ground support systems and facilities. Cross indices and references are provided which relate guidelines to each other, and to substantiating data in other volumes. The guidelines are intended for the implementation of nuclear safety related design and operational considerations in future space programs.

Diesel Fuel from Used Frying Oil

PubMed Central

Buczek, Bronislaw

2014-01-01

New conversion technologies of used edible oils and waste animal fats into a biofuel appropriate for use in standard diesel engines have been developed, taking into consideration environmental requirements and improvement in the economics of current trans-esterification technologies. The variation in the properties of substrates made from used rape oil after treatment with mixed adsorbents (active carbon, magnesium silicate) was studied in this work. The obtained results are compared with the quality requirements for the substrates used in Vogel & Noot GmbH technology for transesterification of oils and fats. PMID:24574908

Definition of avionics concepts for a heavy lift cargo vehicle. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1989-01-01

A cost effective, multiuser simulation, test, and demonstration facility to support the development of avionics systems for future space vehicles is examined. The technology needs and requirements of future Heavy Lift Cargo Vehicles (HLCVs) are analyzed and serve as the basis for sizing of the avionics facility, although the lab is not limited in use to support of HLCVs. Volume 1 provides a summary of the vehicle avionics trade studies, the avionics lab objectives, a summary of the lab's functional requirements and design, physical facility considerations, and cost estimates.

Hospital board structure: changing form and changing issues.

PubMed

Tregoning, S

2000-01-01

Economic and social pressures are compelling many hospitals to consider their current board structure in an effort to position their hospital to meet changing demands. A national profile of the structures of hospital boards has been compiled from a questionnaire completed by hospital board representatives from both government and non-government sectors. Results show that hospital board structures are a hybrid of both philanthropic and corporate models. New structures may be required to meet future challenges. In developing new structures, consideration should be given to identifying the skills and processes required to undertake board business.

Space station experiment definition: Long-term cryogenic fluid storage

NASA Technical Reports Server (NTRS)

Jetley, R. L.; Scarlotti, R. D.

1987-01-01

The conceptual design of a space station Technology Development Mission (TDM) experiment to demonstrate and evaluate cryogenic fluid storage and transfer technologies is presented. The experiment will be deployed on the initial operational capability (IOC) space station for a four-year duration. It is modular in design, consisting of three phases to test the following technologies: passive thermal technologies (phase 1), fluid transfer (phase 2), and active refrigeration (phase 3). Use of existing hardware was a primary consideration throughout the design effort. A conceptual design of the experiment was completed, including configuration sketches, system schematics, equipment specifications, and space station resources and interface requirements. These requirements were entered into the NASA Space Station Mission Data Base. A program plan was developed defining a twelve-year development and flight plan. Program cost estimates are given.

77 FR 68121 - Notice of Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... Acting Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters..., Consumer Financial Protection Bureau), seconded by Director Thomas M. Hoenig (Appointive), concurred in by... earlier notice of the meeting was practicable; that the public interest did not require consideration of...

78 FR 56229 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

..., Consumer Financial Protection Bureau), Director Thomas J. Curry (Comptroller of the Currency), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be... the meeting was practicable; that the public interest did not require consideration of the matters in...

78 FR 3895 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-17

..., Consumer Financial Protection Bureau), Director Thomas J. Curry (Comptroller of the Currency), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be... the meeting was practicable; that the public interest did not require consideration of the matters in...

Systems cost/performance analysis (study 2.3). Volume 2: Systems cost/performance model. [unmanned automated payload programs and program planning

NASA Technical Reports Server (NTRS)

Campbell, B. H.

1974-01-01

A methodology which was developed for balanced designing of spacecraft subsystems and interrelates cost, performance, safety, and schedule considerations was refined. The methodology consists of a two-step process: the first step is one of selecting all hardware designs which satisfy the given performance and safety requirements, the second step is one of estimating the cost and schedule required to design, build, and operate each spacecraft design. Using this methodology to develop a systems cost/performance model allows the user of such a model to establish specific designs and the related costs and schedule. The user is able to determine the sensitivity of design, costs, and schedules to changes in requirements. The resulting systems cost performance model is described and implemented as a digital computer program.

Design and development of a structural mode control system

NASA Technical Reports Server (NTRS)

1977-01-01

A program was conducted to compile and document some of the existing information about the conceptual design, development, and tests of the B-1 structural mode control system (SMCS) and its impact on ride quality. This report covers the following topics: (1) Rationale of selection of SMCS to meet ride quality criteria versus basic aircraft stiffening. (2) Key considerations in designing an SMCS, including vane geometry, rate and deflection requirements, power required, compensation network design, and fail-safe requirements. (3) Summary of key results of SMCS vane wind tunnel tests. (4) SMCS performance. (5) SMCS design details, including materials, bearings, and actuators. (6) Results of qualification testing of SMCS on the "Iron Bird" flight control simulator, and lab qualification testing of the actuators. (7) Impact of SMCS vanes on engine inlet characteristics from wind tunnel tests.

Space Shuttle Solid Rocket Booster decelerator subsystem - Air drop test vehicle/B-52 design

NASA Technical Reports Server (NTRS)

Runkle, R. E.; Drobnik, R. F.

1979-01-01

The air drop development test program for the Space Shuttle Solid Rocket Booster Recovery System required the design of a large drop test vehicle that would meet all the stringent requirements placed on it by structural loads, safety considerations, flight recovery system interfaces, and sequence. The drop test vehicle had to have the capability to test the drogue and the three main parachutes both separately and in the total flight deployment sequence and still be low-cost to fit in a low-budget development program. The design to test large ribbon parachutes to loads of 300,000 pounds required the detailed investigation and integration of several parameters such as carrier aircraft mechanical interface, drop test vehicle ground transportability, impact point ground penetration, salvageability, drop test vehicle intelligence, flight design hardware interfaces, and packaging fidelity.

Buccal Dosage Forms: General Considerations for Pediatric Patients.

PubMed

Montero-Padilla, Soledad; Velaga, Sitaram; Morales, Javier O

2017-02-01

The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives.

Life prediction technologies for aeronautical propulsion systems

NASA Technical Reports Server (NTRS)

Mcgaw, Michael A.

1990-01-01

Fatigue and fracture problems continue to occur in aeronautical gas turbine engines. Components whose useful life is limited by these failure modes include turbine hot-section blades, vanes, and disks. Safety considerations dictate that catastrophic failures be avoided, while economic considerations dictate that catastrophic failures be avoided, while economic considerations dictate that noncatastrophic failures occur as infrequently as possible. Therefore, the decision in design is making the tradeoff between engine performance and durability. LeRC has contributed to the aeropropulsion industry in the area of life prediction technology for over 30 years, developing creep and fatigue life prediction methodologies for hot-section materials. At the present time, emphasis is being placed on the development of methods capable of handling both thermal and mechanical fatigue under severe environments. Recent accomplishments include the development of more accurate creep-fatigue life prediction methods such as the total strain version of LeRC's strain-range partitioning (SRP) and the HOST-developed cyclic damage accumulation (CDA) model. Other examples include the development of a more accurate cumulative fatigue damage rule - the double damage curve approach (DDCA), which provides greatly improved accuracy in comparison with usual cumulative fatigue design rules. Other accomplishments in the area of high-temperature fatigue crack growth may also be mentioned. Finally, we are looking to the future and are beginning to do research on the advanced methods which will be required for development of advanced materials and propulsion systems over the next 10-20 years.

Large space telescope, phase A. Volume 3: Optical telescope assembly

NASA Technical Reports Server (NTRS)

1972-01-01

The development and characteristics of the optical telescope assembly for the Large Space Telescope are discussed. The systems considerations are based on mission-related parameters and optical equipment requirements. Information is included on: (1) structural design and analysis, (2) thermal design, (3) stabilization and control, (4) alignment, focus, and figure control, (5) electronic subsystem, and (6) scientific instrument design.

Water use efficiency at basin and farm scales

Treesearch

Ehsan Goodarzi; Lotfollah Ziaei; Saeid Eslamian

2016-01-01

The available water resources in basins are becoming scarce while demands for water are considerably increasing among various sectors due to economic and population growths. Water deficiency is becoming a main constraint for sustainable regional development and it is the primary motivation in creating water to supply user requirements in particular for agricultural ...

Developing and Implementing an Accreditation Scheme for Disability Services Staff in Post-Compulsory Education in the United Kingdom

ERIC Educational Resources Information Center

Hurst, Alan

2015-01-01

In the United Kingdom (UK), policy and provision for students with disabilities in post-compulsory education has made considerable progress in a relatively short time. This growth has been aided by several factors, arguably the most significant being the introduction of legal requirements in 1995. Many institutions and organisations have tried to…

Progress on lipid extraction from wet algal biomass for biodiesel production.

PubMed

Ghasemi Naghdi, Forough; González González, Lina M; Chan, William; Schenk, Peer M

2016-11-01

Lipid recovery and purification from microalgal cells continues to be a significant bottleneck in biodiesel production due to high costs involved and a high energy demand. Therefore, there is a considerable necessity to develop an extraction method which meets the essential requirements of being safe, cost-effective, robust, efficient, selective, environmentally friendly, feasible for large-scale production and free of product contamination. The use of wet concentrated algal biomass as a feedstock for oil extraction is especially desirable as it would avoid the requirement for further concentration and/or drying. This would save considerable costs and circumvent at least two lengthy processes during algae-based oil production. This article provides an overview on recent progress that has been made on the extraction of lipids from wet algal biomass. The biggest contributing factors appear to be the composition of algal cell walls, pre-treatments of biomass and the use of solvents (e.g. a solvent mixture or solvent-free lipid extraction). We compare recently developed wet extraction processes for oleaginous microalgae and make recommendations towards future research to improve lipid extraction from wet algal biomass. © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

Production of rotational parts in small-series and computer-aided planning of its production engineering

NASA Astrophysics Data System (ADS)

Dudas, Illes; Berta, Miklos; Cser, Istvan

1998-12-01

Up-to-date manufacturing equipments of production of rotational parts in small series are lathe-centers and CNC grinding machines with high concentration of manufacturing operations. By the use of these machine tools it can be produced parts with requirements of increased accuracy and surface quality. In the lathe centers, which contain the manufacturing procedures of lathes using stationary tools and of drilling-milling machine tools using rotational tools, non-rotational surfaces of rotational parts can also be produced. The high concentration of manufacturing operations makes necessary the planning and programing of the measuring, monitoring and quality control into the technological process during manufacturing operation. In this way, taking into consideration the technological possibilities of lathe canters, the scope of computer aided technological planning duties significantly increases. It is trivial requirement to give only once the descriptions of the prefabricated parts and ready made parts. Starting taking into account these careful considerations we have been developing the planning system of technology of body of revolution on the base of GTIPROG/EC system which useful for programming of lathe centers. Out paper deals with the results of development and the occurring problems.

A Programmatic and Engineering Approach to the Development of a Nuclear Thermal Rocket for Space Exploration

NASA Technical Reports Server (NTRS)

Bordelon, Wayne J., Jr.; Ballard, Rick O.; Gerrish, Harold P., Jr.

2006-01-01

With the announcement of the Vision for Space Exploration on January 14, 2004, there has been a renewed interest in nuclear thermal propulsion. Nuclear thermal propulsion is a leading candidate for in-space propulsion for human Mars missions; however, the cost to develop a nuclear thermal rocket engine system is uncertain. Key to determining the engine development cost will be the engine requirements, the technology used in the development and the development approach. The engine requirements and technology selection have not been defined and are awaiting definition of the Mars architecture and vehicle definitions. The paper discusses an engine development approach in light of top-level strategic questions and considerations for nuclear thermal propulsion and provides a suggested approach based on work conducted at the NASA Marshall Space Flight Center to support planning and requirements for the Prometheus Power and Propulsion Office. This work is intended to help support the development of a comprehensive strategy for nuclear thermal propulsion, to help reduce the uncertainty in the development cost estimate, and to help assess the potential value of and need for nuclear thermal propulsion for a human Mars mission.

Intravenous Fluid Mixing in Normal Gravity, Partial Gravity, and Microgravity: Down-Selection of Mixing Methods

NASA Technical Reports Server (NTRS)

Niederhaus, Charles E.; Miller, Fletcher J.

2008-01-01

The missions envisioned under the Vision for Space Exploration will require development of new methods to handle crew medical care. Medications and intravenous (IV) fluids have been identified as one area needing development. Storing certain medications and solutions as powders or concentrates can both increase the shelf life and reduce the overall mass and volume of medical supplies. The powders or concentrates would then be mixed in an IV bag with Sterile Water for Injection produced in situ from the potable water supply. Fluid handling in microgravity is different than terrestrial settings, and requires special consideration in the design of equipment. This document describes the analyses and down-select activities used to identify the IV mixing method to be developed that is suitable for ISS and exploration missions. The chosen method is compatible with both normal gravity and microgravity, maintains sterility of the solution, and has low mass and power requirements. The method will undergo further development, including reduced gravity aircraft experiments and computations, in order to fully develop the mixing method and associated operational parameters.

77 FR 74186 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

..., Consumer Financial Protection Bureau), and Chairman Martin J. Gruenberg, that Corporation business required its consideration of the matters which were to be the subject of this meeting on less than seven days... not require consideration of the matters in a meeting open to public observation; and that the matters...

Developmental Challenges of SMES Technology for Applications

NASA Astrophysics Data System (ADS)

Rong, Charles C.; Barnes, Paul N.

2017-12-01

This paper reviews the current status of high temperature superconductor (HTS) based superconducting magnetic energy storage (SMES) technology as a developmental effort. Discussion centres on the major challenges in magnet optimization, loss reduction, cooling improvement, and new development of quench detection. The cryogenic operation for superconductivity in this technological application requires continued research and development, especially with a greater engineering effort that involves the end user. For the SMES-based technology to more fully mature, some suggestions are given for consideration and discussion.

Grumman electric truck development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kessler, J.C.; Ferdman, S.

1981-11-01

An electric truck development was undertaken to prepare for the markets of the 1980's. Grumman is using its aluminum truck bodies technology to create a light weight vehicle. A redesigned unitized, all aluminum body and a new propulsion system resulted in the desired vehicle. The vehicle meets the requirements of the US Postal Service and the DOE Demonstration program. The unitized chassisless structure is designed to take major driving loads. Design features and performance characteristics are enumerated. Safety and service considerations have been incorporated into the vehicle.

Foreign Investment and National Security: Economic Considerations

DTIC Science & Technology

2008-12-01

overall amount of direct investment flows in 2008 will decline as a result of lower levels of foreign direct investment into and out of the United States...244.4 n.a. 13.7 18.7 n.a. United States 101.0 175.4 192.9 10.7 13.4 12.5 Other developed econ . -34.6 46.7 n.a. -3.7 3.6 n.a. Developing economies...regulatory impact assessments, and requirements that decisions to block an investment should be taken at high government levels

Considerations with respect to the design of solar photovoltaic power systems for terrestrial applications

NASA Technical Reports Server (NTRS)

Berman, P. A.

1972-01-01

The various factors involved in the development of solar photovoltaic power systems for terrestrial application are discussed. The discussion covers the tradeoffs, compromises, and optimization studies which must be performed in order to develop a viable terrestrial solar array system. It is concluded that the technology now exists for the fabrication of terrestrial solar arrays but that the economics are prohibitive. Various approaches to cost reduction are presented, and the general requirements for materials and processes to be used are delineated.

'Emerging technologies for the changing global market' - Prioritization methodology for chemical replacement

NASA Technical Reports Server (NTRS)

Cruit, Wendy; Schutzenhofer, Scott; Goldberg, Ben; Everhart, Kurt

1993-01-01

This project served to define an appropriate methodology for effective prioritization of technology efforts required to develop replacement technologies mandated by imposed and forecast legislation. The methodology used is a semiquantitative approach derived from quality function deployment techniques (QFD Matrix). This methodology aims to weight the full environmental, cost, safety, reliability, and programmatic implications of replacement technology development to allow appropriate identification of viable candidates and programmatic alternatives. The results will be implemented as a guideline for consideration for current NASA propulsion systems.

Emerging technologies for the changing global market

NASA Technical Reports Server (NTRS)

Cruit, Wendy; Schutzenhofer, Scott; Goldberg, Ben; Everhart, Kurt

1993-01-01

This project served to define an appropriate methodology for effective prioritization of technology efforts required to develop replacement technologies mandated by imposed and forecast legislation. The methodology used is a semi-quantative approach derived from quality function deployment techniques (QFD Matrix). This methodology aims to weight the full environmental, cost, safety, reliability, and programmatic implications of replacement technology development to allow appropriate identification of viable candidates and programmatic alternatives. The results will be implemented as a guideline for consideration for current NASA propulsion systems.

Preparing the Production of a New Product in Small and Medium-Sized Enterprises by Using the Method of Projects Management

NASA Astrophysics Data System (ADS)

Bijańska, Jolanta; Wodarski, Krzysztof; Wójcik, Janusz

2016-06-01

Efficient and effective preparation the production of new products is important requirement for a functioning and development of small and medium-sized enterprises. One of the methods, which support the fulfilment of this condition is project management. This publication presents the results of considerations, which are aimed at developing a project management model of preparation the production of a new product, adopted to specificity of small and medium-sized enterprises.

Summary of Plutonium-238 Production Alternatives Analysis Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

James Werner; Wade E. Bickford; David B. Lord

The Team implemented a two-phase evaluation process. During the first phase, a wide variety of past and new candidate facilities and processing methods were assessed against the criteria established by DOE for this assessment. Any system or system element selected for consideration as an alternative within the project to reestablish domestic production of Pu-238 must meet the following minimum criteria: Any required source material must be readily available in the United States, without requiring the development of reprocessing technologies or investments in systems to separate material from identified sources. It must be cost, schedule, and risk competitive with existing baselinemore » technology. Any identified facilities required to support the concept must be available to the program for the entire project life cycle (notionally 35 years, unless the concept is so novel as to require a shorter duration). It must present a solution that can generate at least 1.5 Kg of Pu-238 oxide per year, for at least 35 years. It must present a low-risk, near-term solution to the National Aeronautics and Space Administration’s urgent mission need. DOE has implemented this requirement by eliminating from project consideration any alternative with key technologies at less than Technology Readiness Level 5. The Team evaluated the options meeting these criteria using a more detailed assessment of the reasonable facility variations and compared them to the preferred option, which consists of target irradiation at the Advanced Test Reactor (ATR) and the High Flux Isotope Reactor (HFIR), target fabrication and chemical separations processing at the ORNL Radiochemical Engineering Development Center, and neptunium 237 storage at the Materials and Fuels Complex at INL. This preferred option is consistent with the Records of Decision from the earlier National Environmental Policy Act (NEPA) documentation« less

Extended mission life support systems

NASA Technical Reports Server (NTRS)

Quattrone, P. D.

1985-01-01

Extended manned space missions which include interplanetary missions require regenerative life support systems. Manned mission life support considerations are placed in perspective and previous manned space life support system technology, activities and accomplishments in current supporting research and technology (SR&T) programs are reviewed. The life support subsystem/system technologies required for an enhanced duration orbiter (EDO) and a space operations center (SOC), regenerative life support functions and technology required for manned interplanetary flight vehicles, and future development requirements are outlined. The Space Shuttle Orbiters (space transportation system) is space cabin atmosphere is maintained at Earth ambient pressure of 14.7 psia (20% O2 and 80% N2). The early Shuttle flights will be seven-day flights, and the life support system flight hardware will still utilize expendables.

Consideration of drainage ditches and sediment rating cure on SWAT model performance

USDA-ARS?s Scientific Manuscript database

Water quality models most often require a considerable amount of data to be properly configured and in some cases this requires additional procedural steps prior to model applications. We examined two different scenarios of such input issues in a small watershed using the Soil and Water Assessment ...

32 CFR Enclosure 1 - Requirements for Environmental Considerations-Global Commons

Code of Federal Regulations, 2010 CFR

2010-07-01

... the responsible decision-making official to be informed of pertinent environmental considerations. The... making an appropriate record with respect to this requirement is for the decision-maker to sign and date...-making process. Other means of making an appropriate record are also acceptable. 9. Timing. No decision...

33 CFR 230.17 - Filing requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... supplement, district commanders will establish a time schedule for each step of the process based upon considerations listed in 40 CFR 1501.8 and upon other management considerations. The time required from the... reviews by division and the incorporation of division's comments in the EIS. HQUSACE and/or division will...

Responding to and Supporting Students with Disabilities: Risk Management Considerations

ERIC Educational Resources Information Center

Lundquist, Anne; Shackelford, Allan

2011-01-01

Making the "right" risk management decisions involving students with significant psychological disabilities requires a clear and comprehensive understanding of the legal obligations and duties at issue. It also requires taking into consideration the best interests of these individual students. At the same time, decision makers must focus…

Meaningful Use of Electronic Health Records: Experiences From the Field and Future Opportunities.

PubMed

Slight, Sarah Patricia; Berner, Eta S; Galanter, William; Huff, Stanley; Lambert, Bruce L; Lannon, Carole; Lehmann, Christoph U; McCourt, Brian J; McNamara, Michael; Menachemi, Nir; Payne, Thomas H; Spooner, S Andrew; Schiff, Gordon D; Wang, Tracy Y; Akincigil, Ayse; Crystal, Stephen; Fortmann, Stephen P; Bates, David W

2015-09-18

With the aim of improving health care processes through health information technology (HIT), the US government has promulgated requirements for "meaningful use" (MU) of electronic health records (EHRs) as a condition for providers receiving financial incentives for the adoption and use of these systems. Considerable uncertainty remains about the impact of these requirements on the effective application of EHR systems. The Agency for Healthcare Research and Quality (AHRQ)-sponsored Centers for Education and Research in Therapeutics (CERTs) critically examined the impact of the MU policy relating to the use of medications and jointly developed recommendations to help inform future HIT policy. We gathered perspectives from a wide range of stakeholders (N=35) who had experience with MU requirements, including academicians, practitioners, and policy makers from different health care organizations including and beyond the CERTs. Specific issues and recommendations were discussed and agreed on as a group. Stakeholders' knowledge and experiences from implementing MU requirements fell into 6 domains: (1) accuracy of medication lists and medication reconciliation, (2) problem list accuracy and the shift in HIT priorities, (3) accuracy of allergy lists and allergy-related standards development, (4) support of safer and effective prescribing for children, (5) considerations for rural communities, and (6) general issues with achieving MU. Standards are needed to better facilitate the exchange of data elements between health care settings. Several organizations felt that their preoccupation with fulfilling MU requirements stifled innovation. Greater emphasis should be placed on local HIT configurations that better address population health care needs. Although MU has stimulated adoption of EHRs, its effects on quality and safety remain uncertain. Stakeholders felt that MU requirements should be more flexible and recognize that integrated models may achieve information-sharing goals in alternate ways. Future certification rules and requirements should enhance EHR functionalities critical for safer prescribing of medications in children.

Formal methods and digital systems validation for airborne systems

NASA Technical Reports Server (NTRS)

Rushby, John

1993-01-01

This report has been prepared to supplement a forthcoming chapter on formal methods in the FAA Digital Systems Validation Handbook. Its purpose is as follows: to outline the technical basis for formal methods in computer science; to explain the use of formal methods in the specification and verification of software and hardware requirements, designs, and implementations; to identify the benefits, weaknesses, and difficulties in applying these methods to digital systems used on board aircraft; and to suggest factors for consideration when formal methods are offered in support of certification. These latter factors assume the context for software development and assurance described in RTCA document DO-178B, 'Software Considerations in Airborne Systems and Equipment Certification,' Dec. 1992.

Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship: Use of Administrative and Surveillance Databases.

PubMed

Drees, Marci; Gerber, Jeffrey S; Morgan, Daniel J; Lee, Grace M

2016-11-01

Administrative and surveillance data are used frequently in healthcare epidemiology and antimicrobial stewardship (HE&AS) research because of their wide availability and efficiency. However, data quality issues exist, requiring careful consideration and potential validation of data. This methods paper presents key considerations for using administrative and surveillance data in HE&AS, including types of data available and potential use, data limitations, and the importance of validation. After discussing these issues, we review examples of HE&AS research using administrative data with a focus on scenarios when their use may be advantageous. A checklist is provided to help aid study development in HE&AS using administrative data. Infect Control Hosp Epidemiol 2016;1-10.

Radiation Shielding for Nuclear Thermal Propulsion

NASA Technical Reports Server (NTRS)

Caffrey, Jarvis A.

2016-01-01

Design and analysis of radiation shielding for nuclear thermal propulsion has continued at Marshall Space Flight Center. A set of optimization tools are in development, and strategies for shielding optimization will be discussed. Considerations for the concurrent design of internal and external shielding are likely required for a mass optimal shield design. The task of reducing radiation dose to crew from a nuclear engine is considered to be less challenging than the task of thermal mitigation for cryogenic propellant, especially considering the likely implementation of additional crew shielding for protection from solar particles and cosmic rays. Further consideration is thus made for the thermal effects of radiation absorption in cryogenic propellant. Materials challenges and possible methods of manufacturing are also discussed.

Role of Anesthesiologist in the Management of a Child with Cerebral Palsy

PubMed Central

Shaikh, Safiya Imtiaz; Hegade, Ganapati

2017-01-01

Cerebral palsy (CP) refers to a spectrum of nonprogressive neurological disorders with disturbances in posture and movement, resulting from perinatal intrauterine insult to developing infant brain. Many conditions associated with CP require surgery. Such cases pose important gastrointestinal, respiratory, and other perioperative considerations. Anesthetic management in these cases is delicate. Intraoperative complications including hypovolemia, hypothermia, muscle spasms, seizures, and delayed recovery might complicate the anesthetic management. A thorough preanesthetic evaluation allows for a better intra- and post-operative care. Postoperative analgesia is important, particularly in orthopedic surgeries one for pain relief. This review highlights the clinical manifestations in CP and anesthetic considerations in such child presenting for various surgeries. PMID:28928544

Description of the computations and pilot procedures for planning fuel-conservative descents with a small programmable calculator

NASA Technical Reports Server (NTRS)

Vicroy, D. D.; Knox, C. E.

1983-01-01

A simplified flight management descent algorithm was developed and programmed on a small programmable calculator. It was designed to aid the pilot in planning and executing a fuel conservative descent to arrive at a metering fix at a time designated by the air traffic control system. The algorithm may also be used for planning fuel conservative descents when time is not a consideration. The descent path was calculated for a constant Mach/airspeed schedule from linear approximations of airplane performance with considerations given for gross weight, wind, and nonstandard temperature effects. The flight management descent algorithm and the vertical performance modeling required for the DC-10 airplane is described.

Guidance, Navigation and Control (GN&C): Best Practices for Human-Rated Spacecraft Systems

NASA Technical Reports Server (NTRS)

Lebsock, Ken; West, John

2008-01-01

In 2007 the NESC completed an in-depth assessment to identify, define and document engineering considerations for the Design Development Test and Evaluation (DDT&E) of human-rated spacecraft systems. This study had been requested by the Astronaut Office at JSC to help them to better understand what is required to ensure safe, robust, and reliable human-rated spacecraft systems. The 22 GN&C engineering Best Practices described in this paper are a condensed version of what appears in the NESC Technical Report. These Best Practices cover a broad range from fundamental system architectural considerations to more specific aspects (e.g., stability margin recommendations) of GN&C system design and development. 15 of the Best Practices address the early phases of a GN&C System development project and the remaining 7 deal with the later phases. Some of these Best Practices will cross-over between both phases. We recognize that this set of GN&C Best Practices will not be universally applicable to all projects and mission applications.

Consideration of Environmental Factors in Planning and Development of Urban Areas

NASA Astrophysics Data System (ADS)

Kustysheva, I.

2017-11-01

Environmental factors, in varying degrees, always have a direct influence on the urban environment formation and the provision of favorable and safe conditions for the life of the population. Their role in the planning and development of urban areas remains an integral part of the management of such areas. Management should be aimed at improving the efficiency of use of the territories and ecological environment improvement. Planning must be done with the consideration of identified ecological processes in cities on the basis of the information about their occurrence in the past and present. Currently, cities face a multitude of problems that require urgent and immediate solutions. One of the most important issues is the poor state of the urban environment, so the environmental factors remain one of the most critical problems that should be considered by the authorities while implementing the urban areas’ development plans. The article discusses the role of environmental factors in the management and planning of urban territories by the example of the city of Tobolsk.

Nutritional adequacy of diets for adolescents with overweight and obesity: considerations for dietetic practice.

PubMed

Lister, N B; Gow, M L; Chisholm, K; Grunseit, A; Garnett, S P; Baur, L A

2017-05-01

Adolescents have unique nutrient requirements due to rapid growth and development. High rates of obesity in adolescents require a variety of diet interventions to achieve weight loss under clinical supervision. The aim of this study is to examine the nutritional adequacy of energy-restricted diets for adolescents. Three popular diets were modelled for 7 days and assessed by comparing the nutrient profile to the Australian Nutrient Reference Values. Three diets were: (1) a standard energy restricted diet based on current dietary guidelines; (2) a modified carbohydrate diet; and (3) a modified alternate day fasting diet. Initial modelling revealed limiting nutrients (that is, not meeting the recommended intakes) across the diets. Subsequent modelling was required to achieve nutritional adequacy for all three diets. The dietary guidelines diet design met most nutrient targets except essential fatty acids before subsequent modelling, however this diet also provided the highest energy (8.8 vs 8.0 MJ and 6.8 MJ for the modified carbohydrate and modified alternate day fasting diet, respectively). Energy-restricted diets need careful consideration to meet nutritional requirements of adolescents. A variety of eating patterns can be adapted to achieve nutritional adequacy and energy restriction, however health practitioners need to consider adequacy when prescribing diet interventions for weight loss during adolescence.

Operational Issues: What Science in Available?

NASA Technical Reports Server (NTRS)

Rosekind, Mark R.; Neri, David F.

1997-01-01

Flight/duty/rest considerations involve two highly complex factors: the diverse demands of aviation operations and human physiology (especially sleep and circadian rhythms). Several core operational issues related to fatigue have been identified, such as minimum rest requirements, duty length, flight time considerations, crossing multiple time zones, and night flying. Operations also can involve on-call reserve status and callout, delays due to unforeseen circumstances (e.g., weather, mechanical), and on-demand flights. Over 40 years of scientific research is now available to apply to these complex issues of flight/duty/rest requirements. This research involves controlled 'laboratory studies, simulations, and data collected during regular flight operations. When flight/duty/rest requirements are determined they are typically based on a variety of considerations, such as operational demand, safety, economic, etc. Rarely has the available, state-of-the-art science been a consideration along with these other factors when determining flight/duty/rest requirements. While the complexity of the operational demand and human physiology precludes an absolute solution, there is an opportunity to take full advantage of the current scientific data. Incorporating these data in a rational operational manner into flight/duty/rest requirements can improve flight crew performance, alertness, and ultimately, aviation safety.

Evaluating cardiac risk: exposure response analysis in early clinical drug development.

PubMed

Grenier, Julie; Paglialunga, Sabina; Morimoto, Bruce H; Lester, Robert M

2018-01-01

The assessment of a drug's cardiac liability has undergone considerable metamorphosis by regulators since International Council for Harmonization of Technical Requirement for Pharmaceuticals for Human Use E14 guideline was introduced in 2005. Drug developers now have a choice in how proarrhythmia risk can be evaluated; the options include a dedicated thorough QT (TQT) study or exposure response (ER) modeling of intensive electrocardiogram (ECG) captured in early clinical development. The alternative approach of ER modeling was incorporated into a guidance document in 2015 as a primary analysis tool which could be utilized in early phase dose escalation studies as an option to perform a dedicated TQT trial. This review will describe the current state of ER modeling of intensive ECG data collected during early clinical drug development; the requirements with regard to the use of a positive control; and address the challenges and opportunities of this alternative approach to assessing QT liability.

Improving health service management education: the manager speaks.

PubMed

Harris, M G; Harris, R D; Tapsell, L

1993-01-01

This paper uses health service manager judgements to discuss educational approaches and environments suitable to the development of required competencies and reports barriers to and opportunities for competency development. Practising managers were found to recognise and value the educational contributions made by academic programs, health service organisations and professional associations to the development of professional competence. Academic programs are seen as the appropriate vehicle for developing conceptual, analytical, problem solving and communication competencies that require considerable maturation time. Health service organisations are seen to have a key role in promoting professional competence through maintaining a culture conductive to encouraging managers to undertake further education, supported by appropriate system strategies. Professional associations are regarded as appropriate sponsors for promoting knowledge and skill update in relation to current issues in management through short courses, conferences and timely educational meetings. Wherever possible, collaboration between professional and educational organisations was seen to be desirable.

Shape Optimization and Modular Discretization for the Development of a Morphing Wingtip

NASA Astrophysics Data System (ADS)

Morley, Joshua

Better knowledge in the areas of aerodynamics and optimization has allowed designers to develop efficient wingtip structures in recent years. However, the requirements faced by wingtip devices can be considerably different amongst an aircraft's flight regimes. Traditional static wingtip devices are then a compromise between conflicting requirements, resulting in less than optimal performance within each regime. Alternatively, a morphing wingtip can reconfigure leading to improved performance over a range of dissimilar flight conditions. Developed within this thesis, is a modular morphing wingtip concept that centers on the use of variable geometry truss mechanisms to permit morphing. A conceptual design framework is established to aid in the development of the concept. The framework uses a metaheuristic optimization procedure to determine optimal continuous wingtip configurations. The configurations are then discretized for the modular concept. The functionality of the framework is demonstrated through a design study on a hypothetical wing/winglet within the thesis.

Drug Development for Pediatric Populations: Regulatory Aspects

PubMed Central

Zisowsky, Jochen; Krause, Andreas; Dingemanse, Jasper

2010-01-01

Pediatric aspects are nowadays integrated early in the development process of a new drug. The stronger enforcement to obtain pediatric information by the regulatory agencies in recent years resulted in an increased number of trials in children. Specific guidelines and requirements from, in particular, the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) form the regulatory framework. This review summarizes the regulatory requirements and strategies for pediatric drug development from an industry perspective. It covers pediatric study planning and conduct, considerations for first dose in children, appropriate sampling strategies, and different methods for data generation and analysis to generate knowledge about the pharmacokinetics (PK) and pharmacodynamics (PD) of a drug in children. The role of Modeling and Simulation (M&S) in pediatrics is highlighted—including the regulatory basis—and examples of the use of M&S are illustrated to support pediatric drug development. PMID:27721363

Implementation of a Multichannel Serial Data Streaming Algorithm using the Xilinx Serial RapidIO Solution

NASA Technical Reports Server (NTRS)

Doxley, Charles A.

2016-01-01

In the current world of applications that use reconfigurable technology implemented on field programmable gate arrays (FPGAs), there is a need for flexible architectures that can grow as the systems evolve. A project has limited resources and a fixed set of requirements that development efforts are tasked to meet. Designers must develop robust solutions that practically meet the current customer demands and also have the ability to grow for future performance. This paper describes the development of a high speed serial data streaming algorithm that allows for transmission of multiple data channels over a single serial link. The technique has the ability to change to meet new applications developed for future design considerations. This approach uses the Xilinx Serial RapidIO LOGICORE Solution to implement a flexible infrastructure to meet the current project requirements with the ability to adapt future system designs.

Smart hands for the EVA retriever

NASA Technical Reports Server (NTRS)

Hess, Clifford W.; Li, Larry C.

1990-01-01

Dexterous, robotic hands are required for the extravehicular activity retriever (EVAR) system being developed by the NASA Johnson Space Center (JSC). These hands, as part of the EVAR system, must be able to grasp objects autonomously and securely which inadvertently separate from the Space Station. Development of the required hands was initiated in 1987. Outlined here are the hand development activities, including design considerations, progress to date, and future plans. Several types of dexterous hands that were evaluated, along with a proximity-sensing capability that was developed to initiate a reflexive, adaptive grasp, are described. The evaluations resulted in the design and fabrication of a 6-degree-of-freedom (DOF) hand that has two fingers and a thumb arranged in an anthropomorphic configuration. Finger joint force and position sensors are included in the design, as well as infrared proximity sensors which allow initiation of the grasp sequence when an object is detected within the grasp envelope.

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.

PubMed

Becker, Richard A; Ankley, Gerald T; Edwards, Stephen W; Kennedy, Sean W; Linkov, Igor; Meek, Bette; Sachana, Magdalini; Segner, Helmut; Van Der Burg, Bart; Villeneuve, Daniel L; Watanabe, Haruna; Barton-Maclaren, Tara S

2015-08-01

Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight of evidence (WoE) analysis has been proposed as a basis for assessment of the maturity and level of confidence in an AOP, methodologies and tools are still being formalized. The Organization for Economic Co-operation and Development (OECD) Users' Handbook Supplement to the Guidance Document for Developing and Assessing AOPs (OECD 2014a; hereafter referred to as the OECD AOP Handbook) provides tailored Bradford-Hill (BH) considerations for systematic assessment of confidence in a given AOP. These considerations include (1) biological plausibility and (2) empirical support (dose-response, temporality, and incidence) for Key Event Relationships (KERs), and (3) essentiality of key events (KEs). Here, we test the application of these tailored BH considerations and the guidance outlined in the OECD AOP Handbook using a number of case examples to increase experience in more transparently documenting rationales for assigned levels of confidence to KEs and KERs, and to promote consistency in evaluation within and across AOPs. The major lessons learned from experience are documented, and taken together with the case examples, should contribute to better common understanding of the nature and form of documentation required to increase confidence in the application of AOPs for specific uses. Based on the tailored BH considerations and defining questions, a prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described. The applicability of the approach is also demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish. Following the acquisition of additional experience in the development and assessment of AOPs, further refinement of parameterization of the model through expert elicitation is recommended. Overall, the application of quantitative WoE approaches hold promise to enhance the rigor, transparency and reproducibility for AOP WoE determinations and may play an important role in delineating areas where research would have the greatest impact on improving the overall confidence in the AOP. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

A Flight Photon Counting Camera for the WFIRST Coronagraph

NASA Astrophysics Data System (ADS)

Morrissey, Patrick

2018-01-01

A photon counting camera based on the Teledyne-e2v CCD201-20 electron multiplying CCD (EMCCD) is being developed for the NASA WFIRST coronagraph, an exoplanet imaging technology development of the Jet Propulsion Laboratory (Pasadena, CA) that is scheduled to launch in 2026. The coronagraph is designed to directly image planets around nearby stars, and to characterize their spectra. The planets are exceedingly faint, providing signals similar to the detector dark current, and require the use of photon counting detectors. Red sensitivity (600-980nm) is preferred to capture spectral features of interest. Since radiation in space affects the ability of the EMCCD to transfer the required single electron signals, care has been taken to develop appropriate shielding that will protect the cameras during a five year mission. In this poster, consideration of the effects of space radiation on photon counting observations will be described with the mitigating features of the camera design. An overview of the current camera flight system electronics requirements and design will also be described.

Societal challenges of precision medicine: Bringing order to chaos.

PubMed

Salgado, Roberto; Moore, Helen; Martens, John W M; Lively, Tracy; Malik, Shakun; McDermott, Ultan; Michiels, Stefan; Moscow, Jeffrey A; Tejpar, Sabine; McKee, Tawnya; Lacombe, Denis

2017-10-01

The increasing number of drugs targeting specific proteins implicated in tumourigenesis and the commercial promotion of relatively affordable genome-wide analyses has led to an increasing expectation among patients with cancer that they can now receive effective personalised treatment based on the often complex genomic signature of their tumour. For such approaches to work in routine practice, the development of correspondingly complex biomarker assays through an appropriate and rigorous regulatory framework will be required. It is becoming increasingly evident that a re-engineering of clinical research is necessary so that regulatory considerations and procedures facilitate the efficient translation of these required biomarker assays from the discovery setting through to clinical application. This article discusses the practical requirements and challenges of developing such new precision medicine strategies, based on leveraging complex genomic profiles, as discussed at the Innovation and Biomarkers in Cancer Drug Development meeting (8th-9th September 2016, Brussels, Belgium). Copyright © 2017 Elsevier Ltd. All rights reserved.

Breaking up is hard to do: the economic impact of provisional funding contingent upon evidence development.

PubMed

Mortimer, Duncan; Li, Jing Jing; Watts, Jennifer; Harris, Anthony

2011-10-01

Funding contingent upon evidence development (FED) has recently been the subject of some considerable debate in the literature but relatively little has been made of its economic impact. We argue that FED has the potential to shorten the lag between innovation and access but may also (i) crowd-out more valuable interventions in situations in which there is a fixed dedicated budget; or (ii) lead to a de facto increase in the funding threshold and increased expenditure growth in situations in which the programme budget is open-ended. Although FED would typically entail periodic review of provisional or interim listings, it may prove difficult to withdraw funding even at cost/QALY ratios well in excess of current listing thresholds. Further consideration of the design and implementation of FED processes is therefore required to ensure that its introduction yields net benefits over existing processes.

Micro and nano devices in passive millimetre wave imaging systems

NASA Astrophysics Data System (ADS)

Appleby, R.

2013-06-01

The impact of micro and nano technology on millimetre wave imaging from the post war years to the present day is reviewed. In the 1950s whisker contacted diodes in mixers and vacuum tubes were used to realise both radiometers and radars but required considerable skill to realise the performance needed. Development of planar semiconductor devices such as Gunn and Schottky diodes revolutionised mixer performance and provided considerable improvement. The next major breakthrough was high frequency transistors based on gallium arsenide which were initially used at intermediate frequencies but later after further development at millimeter wave frequencies. More recently Monolithic Microwave Integrated circuits(MMICs) offer exceptional performance and the opportunity for innovative design in passive imaging systems. In the future the use of micro and nano technology will continue to drive system performance and we can expect to see integration of antennae, millimetre wave and sub millimetre wave circuits and signal processing.

Reliability design and verification for launch-vehicle propulsion systems - Report of an AIAA Workshop, Washington, DC, May 16, 17, 1989

NASA Astrophysics Data System (ADS)

Launch vehicle propulsion system reliability considerations during the design and verification processes are discussed. The tools available for predicting and minimizing anomalies or failure modes are described and objectives for validating advanced launch system propulsion reliability are listed. Methods for ensuring vehicle/propulsion system interface reliability are examined and improvements in the propulsion system development process are suggested to improve reliability in launch operations. Also, possible approaches to streamline the specification and procurement process are given. It is suggested that government and industry should define reliability program requirements and manage production and operations activities in a manner that provides control over reliability drivers. Also, it is recommended that sufficient funds should be invested in design, development, test, and evaluation processes to ensure that reliability is not inappropriately subordinated to other management considerations.

Innovative strategies for early clinical R&D.

PubMed

Butz, Robert F; Morelli, Gaetano

2008-01-01

Developments in translational medicine and regulatory initiatives associated with the FDA's Critical Path Initiative are creating new opportunities for innovation in early clinical R&D. The introduction of the exploratory IND process allows small, 'phase 0' clinical trials to be conducted prior to traditional phase I trials - sometimes requiring considerably less chemistry, manufacturing and controls, or preclinical support. Phase 0 clinical trials involving subtherapeutic, yet pharmacologically active, dose levels can provide an early demonstration of clinical proof of concept; such demonstration is of particular importance to small pharmaceutical and early-stage biotechnology companies. However, these opportunities for rapid entry into the clinic must be balanced by a consideration of the unique risks associated with first-in-human clinical trials, and by accounting for public concerns regarding drug safety in general. This feature review discusses how innovative clinical strategies can be used effectively in early drug development.

Integrating musculoskeletal sonography into rehabilitation: Therapists’ experiences with training and implementation

PubMed Central

Gray, Julie McLaughlin; Frank, Gelya; Roll, Shawn C.

2018-01-01

Musculoskeletal sonography is rapidly extending beyond radiology; however, best practices for successful integration into new practice contexts are unknown. This study explored non-physician experiences with the processes of training and integration of musculoskeletal sonography into rehabilitation. Qualitative data were captured through multiple sources and iterative thematic analysis was used to describe two occupational therapists’ experiences. The dominant emerging theme was competency, in three domains: technical, procedural and analytical. Additionally, three practice considerations were illuminated: (1) understanding imaging within the dynamics of rehabilitation, (2) navigating nuances of interprofessional care, and (3) implications for post-professional training. Findings indicate that sonography training for rehabilitation providers requires multi-level competency development and consideration of practice complexities. These data lay a foundation on which to explore and develop best practices for incorporating sonographic imaging into the clinic as a means for engaging clients as active participants in the rehabilitation process to improve health and rehabilitation outcomes. PMID:28830315

Integrated NTP Vehicle Radiation Design

NASA Technical Reports Server (NTRS)

Caffrey, Jarvis A.; Rodriquez, Mitchell A.

2018-01-01

The development of a nuclear thermal propulsion stage requires consideration for radiation emitted from the nuclear reactor core. Applying shielding mass is an effective mitigating solution, but a better alternative is to incorporate some mitigation strategies into the propulsion stage and crew habitat. In this way, the required additional mass is minimized and the mass that must be applied may in some cases be able to serve multiple purposes. Strategies for crew compartment shielding are discussed that reduce dose from both engine and cosmic sources, and in some cases may also serve to reduce life support risks by permitting abundant water reserves. Early consideration for integrated mitigation solutions in a crewed nuclear thermal propulsion (NTP) vehicle will enable reduced radiation burden from both cosmic and nuclear sources, improved thrust-to-weight ratio or payload capacity by reducing 'dead mass' of shielding, and generally support a more robust risk posture for a NTP-powered Mars mission by permitting shorter trip times and increased water reserves.

Focusing the Sun: State Considerations for Designing Community Solar Policy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, Jeffrey J; Shah, Monisha R

This report summarizes outcomes from the National Community Solar Partnership State Best Practices working group by identifying key differences in state policies that enable community solar and illustrating how various policy design approaches may impact the market. For the latter question, it is too early to quantify a relationship between policy design and market impacts, because most state programs have not been fully implemented. So, the authors conducted interviews with 19 subject matter experts, including project developers, regulators, and utilities to better understand how various policy design approaches may impact community solar markets. These perspectives, along with those gleaned frommore » the working group and relevant literature were synthesized to identify key considerations for policymakers designing community solar programs. Though state community solar policies vary in numerous ways, the report focuses on the following critical elements: program cap, project size cap, subscriber location requirements, subscriber eligibility requirements, low- and moderate-income stipulations, and subscriber compensation.« less

Integrated NTP Vehicle Radiation Design

NASA Technical Reports Server (NTRS)

Caffrey, Jarvis; Rodriquez, Mitchell

2018-01-01

The development of a nuclear thermal propulsion stage requires consideration for radiation emitted from the nuclear reactor core. Applying shielding mass is an effective mitigating solution, but a better alternative is to incorporate some mitigation strategies into the propulsion stage and crew habitat. In this way, the required additional mass is minimized and the mass that must be applied may in some cases be able to serve multiple purposes. Strategies for crew compartment shielding are discussed that reduce dose from both engine and cosmic sources, and in some cases may also serve to reduce life support risks by permitting abundant water reserves. Early consideration for integrated mitigation solutions in a crewed nuclear thermal propulsion (NTP) vehicle will enable reduced radiation burden from both cosmic and nuclear sources, improved thrust-to-weight ratio or payload capacity by reducing 'dead mass' of shielding, and generally support a more robust risk posture for a NTP-powered Mars mission by permitting shorter trip times and increased water reserves

Ethical issues in health workforce development.

PubMed Central

Cash, Richard

2005-01-01

Increasing the numbers of health workers and improving their skills requires that countries confront a number of ethical dilemmas. The ethical considerations in answering five important questions on enabling health workers to deal appropriately with the circumstances in which they must work are described. These include the problems of the standards of training and practice required in countries with differing levels of socioeconomic development and different priority diseases; how a society can be assured that health practitioners are properly trained; how a health system can support its workers; diversion of health workers and training institutions; and the teaching of ethical principles to student health workers. The ethics of setting standards for the skills and care provided by traditional health-care practitioners are also discussed. PMID:15868019

Some key considerations in evolving a computer system and software engineering support environment for the space station program

NASA Technical Reports Server (NTRS)

Mckay, C. W.; Bown, R. L.

1985-01-01

The space station data management system involves networks of computing resources that must work cooperatively and reliably over an indefinite life span. This program requires a long schedule of modular growth and an even longer period of maintenance and operation. The development and operation of space station computing resources will involve a spectrum of systems and software life cycle activities distributed across a variety of hosts, an integration, verification, and validation host with test bed, and distributed targets. The requirement for the early establishment and use of an apporopriate Computer Systems and Software Engineering Support Environment is identified. This environment will support the Research and Development Productivity challenges presented by the space station computing system.

Solar array study for solar electric propulsion spacecraft for the Encke rendezvous mission

NASA Technical Reports Server (NTRS)

Sequeira, E. A.; Patterson, R. E.

1974-01-01

The work is described which was performed on the design, analysis and performance of a 20 kW rollup solar array capable of meeting the design requirements of a solar electric spacecraft for the 1980 Encke rendezvous mission. To meet the high power requirements of the proposed electric propulsion mission, solar arrays on the order of 186.6 sq m were defined. Because of the large weights involved with arrays of this size, consideration of array configurations is limited to lightweight, large area concepts with maximum power-to-weight ratios. Items covered include solar array requirements and constraints, array concept selection and rationale, structural and electrical design considerations, and reliability considerations.

ISS ECLSS Technology Evolution for Exploration

NASA Technical Reports Server (NTRS)

Carrasquillo, Robyn

2005-01-01

The baseline environmental control and life support systems (ECLSS) currently deployed on the International Space Station (ISS) and the regenerative oxygen generation and water early 1990's. While they are generally meeting, or exceeding requirements for supporting the ISS crew, lessons learned from hardware development and on orbit experience, together with advances in technology state of the art, and th&e unique requirements for future manned exploration missions prompt consideration of the next steps to be taken to evolve these technologies to improve robustness and reliability, enhance performance, and reduce resource requirements such as power and logistics upmass This paper discusses the current state of ISS ECLSS technology and identifies possible areas for evolutionary enhancement or improvement.

Increasing persistency in lay and stabilising egg quality in longer laying cycles. What are the challenges?

PubMed Central

Bain, M. M.; Nys, Y.; Dunn, I.C.

2016-01-01

Abstract In the past 50 years, selection starting initially at the breed level and then using quantitative genetics coupled with a sophisticated breeding pyramid, has resulted in a very productive hybrid for a variety of traits associated with egg production.One major trait currently being developed further is persistency of lay and the concept of the “long life” layer. Persistency in lay however cannot be achieved without due consideration of how to sustain egg quality and the health and welfare of the birds in longer laying cycles. These multiple goals require knowledge and consideration of the bird’s physiology, nutritional requirements, which vary depending on age and management system, reproductive status and choice of the selection criteria applied.The recent advent of molecular genetics offers considerable hope that these multiple elements can be balanced for the good of all in the industry including the hens.The “long life” layer, which will be capable of producing 500 eggs in a laying cycle of 100 weeks, is therefore on the horizon, bringing with it the benefits of a more efficient utilisation of diminishing resources, including land, water, raw materials for feed as well as a reduction in waste, and an overall reduced carbon footprint. PMID:26982003

Increasing persistency in lay and stabilising egg quality in longer laying cycles. What are the challenges?

PubMed

Bain, M M; Nys, Y; Dunn, I C

2016-06-01

In the past 50 years, selection starting initially at the breed level and then using quantitative genetics coupled with a sophisticated breeding pyramid, has resulted in a very productive hybrid for a variety of traits associated with egg production. One major trait currently being developed further is persistency of lay and the concept of the "long life" layer. Persistency in lay however cannot be achieved without due consideration of how to sustain egg quality and the health and welfare of the birds in longer laying cycles. These multiple goals require knowledge and consideration of the bird's physiology, nutritional requirements, which vary depending on age and management system, reproductive status and choice of the selection criteria applied. The recent advent of molecular genetics offers considerable hope that these multiple elements can be balanced for the good of all in the industry including the hens. The "long life" layer, which will be capable of producing 500 eggs in a laying cycle of 100 weeks, is therefore on the horizon, bringing with it the benefits of a more efficient utilisation of diminishing resources, including land, water, raw materials for feed as well as a reduction in waste, and an overall reduced carbon footprint.

A Preliminary Economic Evaluation of Marine Corps Acquisition Practices: UHF Satellite Communication Ground Terminal Acquisitions

DTIC Science & Technology

1989-03-01

34 Replace outdated teletypewriter/printer technology with the four AN/ UGC - 74’s; " Upgrade communication security (COMSEC) equipment to retain...unbiased information. In fact, the private user recognizes that good marketing techniques are required to receive favorable consideration for a private...developed in accounting, finance, economics, marketing , political science, sociology, and organizational behavior literature. "[The principal-agent

Management Information System

NASA Technical Reports Server (NTRS)

1984-01-01

New Automated Management Information Center (AMIC) employs innovative microcomputer techniques to create color charts, viewgraphs, or other data displays in a fraction of the time formerly required. Developed under Kennedy Space Center's contract by Boeing Services International Inc., Seattle, WA, AMIC can produce an entirely new informational chart in 30 minutes, or an updated chart in only five minutes. AMIC also has considerable potential as a management system for business firms.

Wind power. [electricity generation

NASA Technical Reports Server (NTRS)

Savino, J. M.

1975-01-01

A historical background on windmill use, the nature of wind, wind conversion system technology and requirements, the economics of wind power and comparisons with alternative systems, data needs, technology development needs, and an implementation plan for wind energy are presented. Considerable progress took place during the 1950's. Most of the modern windmills feature a wind turbine electricity generator located directly at the top of their rotor towers.

Power sources for autonomous underwater vehicles

NASA Astrophysics Data System (ADS)

Hasvold, Øistein; Størkersen, Nils J.; Forseth, Sissel; Lian, Torleif

The paper addresses the general requirements for power sources for AUVs, including battery and semi-fuel cell design and safety considerations. The focus is on the last AUV in the HUGIN family: the HUGIN 1000 mine reconnaissance system. For this AUV, FFI recently developed a pressure tolerant lithium ion battery based on commercially available polymer cells. The Royal Norwegian Navy has been operating HUGIN 1000 since February 2004.

Research in space commercialization, technology transfer and communications, vol. 2

NASA Technical Reports Server (NTRS)

Dunn, D. A.; Agnew, C. E.

1983-01-01

Spectrum management, models for evaluating communications systems, and implications of communications regulations for NASA are considered as major parts of communications policy. Marketing LANDSAT products in developing countries, a political systems analysis of LANDSAT, and private financing and operation of the space operations center (space station) are discussed. Investment requirements, risks, government support, and other primary business and management considerations are examined.

Coupling Considerations in Assembly Language

DTIC Science & Technology

2018-01-05

report discusses coupling issues arising in assembly language source code, as contrasted to similar issues arising in high order language (HOL...Warfare Center Weapons Division (NAWCWD) require compliance with DO-178B and DO-178C, which contain guidelines relating to data and control coupling. The...considered unknown, but its effect on development and maintenance will serve as indicators on whether the coupling measure is high or low. Both

DOE Office of Scientific and Technical Information (OSTI.GOV)

Norsworthy, R.

A rating system was developed for several coating types used for underground pipeline systems. Consideration included soil stress, adhesion, surface preparation, cathodic protection (CP) shielding, CP requirements, handling and construction, repair, field joint system, bends and other components, and the application process. Polyethylene- and polyvinyl chloride-backed tapes, woven polyolefin geotextile fabric (WGF)-backed tapes, hot-applied tapes, petrolatum- and wax-based tapes, and shrink sleeves were evaluated. WGF-backed tapes had the highest rating.

Photorefractive Polymers for Updateable 3D Displays

DTIC Science & Technology

2010-02-24

Holographic 3D displays provide highly realistic images without the need for special eyewear , making them valuable tools for applications that require...situational awareness” such as medical, industrial , and military imaging. A considerable amount of research has been dedicated to the development of...imaging techniques that rely on special eyewear such as polarizing goggles have unwanted side-effects such as eye fatigue and motion sickness and

Securing SSL-VPN with LR-AKE to access personal health record.

PubMed

Eizen, Kimura; Masato, Saito; Kazukuni, Kobara; Yoshihito, Nakato; Takuji, Kuroda; Ken, Ishihara

2013-01-01

Using SSL-VPN requires special considerations for well-known issues such as attackers exploiting web browser vulnerabilities and phishing sites using man-in-the-middle attacks. We used leakage-resilient authenticated key exchange (LR-AKE) to develop a comprehensive solution to SSL-VPN issues. Our results show that the LR-AKE should contribute to building a robust infrastructure for personal health records.

The James Webb Telescope Instrument Suite Layout: Optical System Engineering Considerations for a Large, Deployable Space Telescope

NASA Technical Reports Server (NTRS)

Bos, Brent; Davila, Pam; Jurotich, Matthew; Hobbs, Gurnie; Lightsey, Paul; Contreras, Jim; Whitman, Tony

2003-01-01

The James Webb Space Telescope (JWST) is a space-based, infrared observatory designed to study the early stages of galaxy formation in the Universe. The telescope will be launched into an elliptical orbit about the second Lagrange point and passively cooled to 30-50 K to enable astronomical observations from 0.6 to 28 microns. A group from the NASA Goddard Space Flight Center and the Northrop Grumman Space Technology prime contractor team has developed an optical and mechanical layout for the science instruments within the JWST field of view that satisfies the telescope s high-level performance requirements. Four instruments required accommodation within the telescope's field of view: a Near-Infrared Camera (NIRCam) provided by the University of Arizona; a Near-Mared Spectrometer (NIRSpec) provided by the European Space Agency; a Mid-Infrared Instrument (MIRI) provided by the Jet Propulsion Laboratory and a European consortium; and a Fine Guidance Sensor (FGS) with a tunable filter module provided by the Canadian Space Agency. The size and position of each instrument's field of view allocation were developed through an iterative, concurrent engineering process involving the key observatory stakeholders. While some of the system design considerations were those typically encountered during the development of an infrared observatory, others were unique to the deployable and controllable nature of JWST. This paper describes the optical and mechanical issues considered during the field of view layout development, as well as the supporting modeling and analysis activities.

Mammalian pre-implantation chromosomal instability: species comparison, evolutionary considerations, and pathological correlations.

PubMed

Carbone, Lucia; Chavez, Shawn L

2015-01-01

Pre-implantation embryo development in mammals begins at fertilization with the migration and fusion of the maternal and paternal pro-nuclei, followed by the degradation of inherited factors involved in germ cell specification and the activation of embryonic genes required for subsequent cell divisions, compaction, and blastulation. The majority of studies on early embryogenesis have been conducted in the mouse or non-mammalian species, often requiring extrapolation of the findings to human development. Given both conserved similarities and species-specific differences, however, even comparison between closely related mammalian species may be challenging as certain aspects, including susceptibility to chromosomal aberrations, varies considerably across mammals. Moreover, most human embryo studies are limited to patient samples obtained from in vitro fertilization (IVF) clinics and donated for research, which are generally of poorer quality and produced with germ cells that may be sub-optimal. Recent technical advances in genetic, epigenetic, chromosomal, and time-lapse imaging analyses of high quality whole human embryos have greatly improved our understanding of early human embryogenesis, particularly at the single embryo and cell level. This review summarizes the major characteristics of mammalian pre-implantation development from a chromosomal perspective, in addition to discussing the technological achievements that have recently been developed to obtain this data. We also discuss potential translation to clinical applications in reproductive medicine and conclude by examining the broader implications of these findings for the evolution of mammalian species and cancer pathology in somatic cells.

Assessment of a Hospital Palliative Care Unit (HPCU) for Cancer Patients; A Conceptual Framework.

PubMed

Rouhollahi, Mohammad Reza; Saghafinia, Masoud; Zandehdel, Kazem; Motlagh, Ali Ghanbari; Kazemian, Ali; Mohagheghi, Mohammad Ali; Tahmasebi, Mamak

2015-01-01

The first hospital palliative care unit (HPCU) in Iran (FARS-HPCU) has been established in 2008 in the Cancer Institute, which is the largest referral cancer center in the country. We attempted to assess the performance of the HPCU based on a comprehensive conceptual framework. The main aim of this study was to develop a conceptual framework for assessment of the HPCU performances through designing a value chain in line with the goals and the main processes (core and support). We collected data from a variety of sources, including international guidelines, international best practices, and expert opinions in the country and compared them with national policies and priorities. We also took into consideration the trend of the HPCU development in the Cancer Institute of Iran. Through benchmarking the gap area with the performance standards, some recommendations for better outcome are proposed. The framework for performance assessment consisted of 154 process indicators (PIs), based on which the main stakeholders of the HPCU (including staff, patients, and families) offered their scoring. The outcome revealed the state of the processes as well as the gaps. Despite a significant improvement in many processes and indicators, more development in the comprehensive and integrative aspects of FARS-HPCU performance is required. Consideration of all supportive and palliative requirements of the patients through interdisciplinary and collaborative approaches is recommended.

Information Science Panel joint meeting with Imaging Science Panel

NASA Technical Reports Server (NTRS)

1982-01-01

Specific activity in information extraction science (taken to include data handling) is needed to: help identify the bounds of practical missions; identify potential data handling and analysis scenarios; identify the required enabling technology; and identify the requirements for a design data base to be used by the disciplines in determining potential parameters for future missions. It was defined that specific analysis topics were a function of the discipline involved, and therefore no attempt was made to define any specific analysis developments required. Rather, it was recognized that a number of generic data handling requirements exist whose solutions cannot be typically supported by the disciplines. The areas of concern were therefore defined as: data handling aspects of system design considerations; enabling technology for data handling, with specific attention to rectification and registration; and enabling technology for analysis. Within each of these areas, the following topics were addressed: state of the art (current status and contributing factors); critical issues; and recommendations for research and/or development.

Observations of the Performance of the U.S. Laboratory Architecture

NASA Technical Reports Server (NTRS)

Jones, Rod

2002-01-01

The United States Laboratory Module "Destiny" was the product of many architectural, technology, manufacturing, schedule and cost constraints which spanned 15 years. Requirements for the Space Station pressurized elements were developed and baselined in the mid to late '80's. Although the station program went through several design changes the fundamental requirements that drove the architecture did not change. Manufacturing of the U.S. Laboratory began in the early 90's. Final assembly and checkout testing completed in December of 2000. Destiny was launched, mated to the International Space Station and successfully activated on the STS-98 mission in February of 2001. The purpose of this paper is to identify key requirements, which directly or indirectly established the architecture of the U.S. Laboratory. Provide an overview of how that architecture affected the manufacture, assembly, test, and activation of the module on-orbit. And finally, through observations made during the last year of operation, provide considerations in the development of future requirements and mission integration controls for space habitats.

47 CFR 73.3561 - Staff consideration of applications requiring Commission action.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Staff consideration of applications requiring...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.3561 Staff... is reviewed by the staff and, except where the application is acted upon by the staff pursuant to...

47 CFR 73.3561 - Staff consideration of applications requiring Commission action.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Staff consideration of applications requiring...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.3561 Staff... is reviewed by the staff and, except where the application is acted upon by the staff pursuant to...

47 CFR 73.3561 - Staff consideration of applications requiring Commission action.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Staff consideration of applications requiring...) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.3561 Staff... is reviewed by the staff and, except where the application is acted upon by the staff pursuant to...

Management of recurrent or metastatic thyroid cancer.

PubMed

Tahara, Makoto

2018-01-01

Recently, vascular endothelial growth factor receptor (VEGFR)-targeted tyrosine kinase inhibitors (TKIs) have become available for the treatment of recurrent or metastatic thyroid cancer. However, a number of clinical challenges that impact the use of VEGFR-targeted TKI in daily clinical practice have arisen. Toxicity is considerable, to the extent that most physicians hesitate to start VEGFR-targeted TKI and prefer to continue a watch-and-wait approach until the patient's disease markedly worsens. This delayed use of VEGFR-targeted TKI leads to a higher incidence of serious adverse events than was reported in clinical trials. Moreover, the watch-and-wait approach has several demerits, including a worsening of quality of life, worsening of outcomes in patients of older age or with follicular thyroid cancer and increased risk of brain metastasis or bleeding. Thus, optimal timing for the start of VEGFR-targeted TKI requires careful consideration. Moreover, management of VEGFR-targeted TKI toxicities requires appropriate supportive care, well-organised infrastructure in the outpatient clinic and patient education. Future treatment will progress to precision medicine based on molecular testing. Promotion of precision medicine requires the establishment of a system of easy access to molecular testing and the promotion of translational research for the development of new drugs.

Functional Interface Considerations within an Exploration Life Support System Architecture

NASA Technical Reports Server (NTRS)

Perry, Jay L.; Sargusingh, Miriam J.; Toomarian, Nikzad

2016-01-01

As notional life support system (LSS) architectures are developed and evaluated, myriad options must be considered pertaining to process technologies, components, and equipment assemblies. Each option must be evaluated relative to its impact on key functional interfaces within the LSS architecture. A leading notional architecture has been developed to guide the path toward realizing future crewed space exploration goals. This architecture includes atmosphere revitalization, water recovery and management, and environmental monitoring subsystems. Guiding requirements for developing this architecture are summarized and important interfaces within the architecture are discussed. The role of environmental monitoring within the architecture is described.

Unified Framework for Development, Deployment and Robust Testing of Neuroimaging Algorithms

PubMed Central

Joshi, Alark; Scheinost, Dustin; Okuda, Hirohito; Belhachemi, Dominique; Murphy, Isabella; Staib, Lawrence H.; Papademetris, Xenophon

2011-01-01

Developing both graphical and command-line user interfaces for neuroimaging algorithms requires considerable effort. Neuroimaging algorithms can meet their potential only if they can be easily and frequently used by their intended users. Deployment of a large suite of such algorithms on multiple platforms requires consistency of user interface controls, consistent results across various platforms and thorough testing. We present the design and implementation of a novel object-oriented framework that allows for rapid development of complex image analysis algorithms with many reusable components and the ability to easily add graphical user interface controls. Our framework also allows for simplified yet robust nightly testing of the algorithms to ensure stability and cross platform interoperability. All of the functionality is encapsulated into a software object requiring no separate source code for user interfaces, testing or deployment. This formulation makes our framework ideal for developing novel, stable and easy-to-use algorithms for medical image analysis and computer assisted interventions. The framework has been both deployed at Yale and released for public use in the open source multi-platform image analysis software—BioImage Suite (bioimagesuite.org). PMID:21249532

Sustainable development and the exploitation of mineral and energy resources: a review

NASA Astrophysics Data System (ADS)

Wellmer, F.-W.; Becker-Platen, J. D.

2002-04-01

Natural resources, e.g., metals, industrial minerals, water, and soil, are the essential basis for our economy and well-being. We have to know where these raw materials come from and how they are mined. Sustainable development requires the maintenance, rational use and enhancement of natural resources, as well as a balanced consideration of ecology, economy and social justice. Four general rules concerning the implementation of sustainable development for renewable and non-renewable resources are discussed. Examples of the consumption of selected materials from historical times to the present day are presented, as well as of regional distribution, usage (in contrast to consumption), lifetimes of resources, the supply-and-demand cycle, recycling and substitution in modern times. To fulfill the requirement of sustainable development, the efficiency with which resources are utilized has to be improved. The learning process, often driven by financial rewards, leads from one technology to a better one, thus increasing the efficiency of the use of a resource or commodity. Examples of learning curves are discussed. Industrial countries have to transfer their advanced technologies to developing countries in order to avoid undesirable development in the mining industry and use of natural resources in those regions. The use of the best available technology by the mining industry, taking into account economic considerations, and the necessity to establish environmental guidelines are essential if environmental impact of the production of non-renewable resources is to be minimized. Far more critical than the production of non-renewable resources under the aspect of sustainable development and the capacity of the pollutant sinks of the Earth is the element of natural attenuation with regard to the resources soil and water.

Definition of avionics concepts for a heavy lift cargo vehicle, volume 2

NASA Technical Reports Server (NTRS)

1989-01-01

A cost effective, multiuser simulation, test, and demonstration facility to support the development of avionics systems for future space vehicles is defined. The technology needs and requirements of future Heavy Lift Cargo Vehicles (HLCVs) are analyzed and serve as the basis for sizing of the avionics facility although the lab is not limited in use to support of HLCVs. Volume 2 is the technical volume and provides the results of the vehicle avionics trade studies, the avionics lab objectives, the lab's functional requirements and design, physical facility considerations, and a summary cost estimate.

Interdependence of science requirements and safety limitations on the space station

NASA Technical Reports Server (NTRS)

Barber, Patrick G.

1990-01-01

One of the benefits of experimentation on the Space Station is the ability to carry out the experiment, to immediately analyze the results, to calculate improved experimental parameters, and to quickly repeat the experiment. In this improved mode of operation there are new safety considerations that must be addressed in the design stages of both the station and the experiments. Some of the chemical and procedural requirements are shared, and some of the earth-bound storage, dispensing, and disposal techniques that may assist in the development of analogous procedures for the Space Station are discussed.

Space station needs, attributes, and architectural options: Space station program cost analysis

NASA Technical Reports Server (NTRS)

Cowls, R. S.; Goodwin, A. J.

1983-01-01

This report documents the principal cost results (Task 3) derived from the Space Station Needs, Attributes, and Architectural Options study conducted for NASA by the McDonnell Douglas Astronautics Company. The determined costs were those of Architectural Options (Task 2) defined to satisfy Mission Requirements (Task 1) developed within the study. A major feature of this part of the study was the consideration of realistic NASA budget constraints on the recommended architecture. Thus, the space station funding requirements were adjusted by altering schedules until they were consistent with current NASA budget trends.

Dust control research for SEI. [Space Exploration Initiative

NASA Technical Reports Server (NTRS)

Kennedy, Kriss J.; Harris, Jeffrey R.

1992-01-01

A study, at NASA Johnson Space Center, of dust control requirements for surface habitats has focused on identification of the dust problem, identifying dust control techniques and dust control technology areas requiring research development. This research was performed for the Surface Habitats and Construction (SHAC) technology area. Dust control consists of two problems: (1) how to keep it out of the habitat; and (2) once the habitat or airlock is contaminated with dust, how to collect it. This paper describes the dust environment, the Apollo experience and dust control methods used, future EVA operational considerations, and dust control concepts for surface habitats.

Translating supportability requirements into design reality

NASA Astrophysics Data System (ADS)

Buche, J.; Cohen, I.

1986-10-01

This paper explores some of the principal issues in the integration of supportability into the design process. Roles of the contractor's design, supportability and management specialists and their government counterparts are discussed as they relate to logistics influence in design. Methods and processes by which weapon system logistics and readiness requirements are established, assessed, allocated to system elements and translated into specific design features are described. Tradeoff consideration, an approach to effective tradeoff criteria, and the progress of supportability issues through the program phases are identified with particular emphasis on the necessity for developing and maintaining an effective audit trail.

Biosensor technology: technology push versus market pull.

PubMed

Luong, John H T; Male, Keith B; Glennon, Jeremy D

2008-01-01

Biosensor technology is based on a specific biological recognition element in combination with a transducer for signal processing. Since its inception, biosensors have been expected to play a significant analytical role in medicine, agriculture, food safety, homeland security, environmental and industrial monitoring. However, the commercialization of biosensor technology has significantly lagged behind the research output as reflected by a plethora of publications and patenting activities. The rationale behind the slow and limited technology transfer could be attributed to cost considerations and some key technical barriers. Analytical chemistry has changed considerably, driven by automation, miniaturization, and system integration with high throughput for multiple tasks. Such requirements pose a great challenge in biosensor technology which is often designed to detect one single or a few target analytes. Successful biosensors must be versatile to support interchangeable biorecognition elements, and in addition miniaturization must be feasible to allow automation for parallel sensing with ease of operation at a competitive cost. A significant upfront investment in research and development is a prerequisite in the commercialization of biosensors. The progress in such endeavors is incremental with limited success, thus, the market entry for a new venture is very difficult unless a niche product can be developed with a considerable market volume.

Maintainability Program Requirements for Space Systems

NASA Technical Reports Server (NTRS)

1987-01-01

This document is established to provide common general requirements for all NASA programs to: design maintainability into all systems where maintenance is a factor in system operation and mission success; and ensure that maintainability characteristics are developed through the systems engineering process. These requirements are not new. Design for ease of maintenance and minimization of repair time have always been fundamental requirements of the systems engineering process. However, new or reusable orbital manned and in-flight maintainable unmanned space systems demand special emphasis on maintainability, and this document has been prepared to meet that need. Maintainability requirements on many NASA programs differ in phasing and task emphasis from requirements promulgated by other Government agencies. This difference is due to the research and development nature of NASA programs where quantities produced are generally small; therefore, the depth of logistics support typical of many programs is generally not warranted. The cost of excessive maintenance is very high due to the logistics problems associated with the space environment. The ability to provide timely maintenance often involves safety considerations for manned space flight applications. This document represents a basic set of requirements that will achieve a design for maintenance. These requirements are directed primarily at manned and unmanned orbital space systems. To be effective, maintainability requirements should be tailored to meet specific NASA program and project needs and constraints. NASA activities shall invoke the requirements of this document consistent with program planning in procurements or on inhouse development efforts.

Regional Transmission Planning: A review of practices following FERC Order Nos. 890 and 1000

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eto, Joseph H.; Gallo, Guilia

Federal Energy Regulatory Commission (FERC) Order Nos. 890 and 10001 established requirements that transmission planning regions must follow in regional transmission planning and allocating the costs of new transmission facilities. Order No. 890, issued in 2007, outlined general requirements for local as well as regional transmission planning practices and procedures. Order No. 1000, issued in 2011, laid out specific requirements for: (1) regional transmission planning; (2) consideration of transmission needs driven by public policy requirements; (3) non-incumbent transmission development; (4) interregional transmission coordination; and (5) cost allocation for transmission facilities that have been selected in a regional transmission plan formore » purposes of cost allocation. This report reviews how these FERC orders are being implemented by the 12 transmission planning regions recognized by FERC.« less

40 CFR 194.51 - Consideration of protected individual.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Consideration of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 Consideration of protected individual...

40 CFR 194.51 - Consideration of protected individual.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Consideration of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 Consideration of protected individual...

40 CFR 194.51 - Consideration of protected individual.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Consideration of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 Consideration of protected individual...

40 CFR 194.51 - Consideration of protected individual.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Consideration of protected individual. 194.51 Section 194.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual and Ground-Water Protection Requirements § 194.51 Consideration of protected individual...

Regulatory and ethical considerations for linking clinical and administrative databases.

PubMed

Dokholyan, Rachel S; Muhlbaier, Lawrence H; Falletta, John M; Jacobs, Jeffrey P; Shahian, David; Haan, Constance K; Peterson, Eric D

2009-06-01

Clinical data registries are valuable tools that support evidence development, performance assessment, comparative effectiveness studies, and the adoption of new treatments into routine clinical practice. Although these registries do not have important information on long-term therapies or clinical events, administrative claims databases offer a potentially valuable complement. This article focuses on the regulatory and ethical considerations that arise from the use of registry data for research, including linkage of clinical and administrative data sets. (1) Are such activities primarily designed for quality assessment and improvement, research, or both, as this determines the appropriate ethical and regulatory standards? (2) Does the submission of data to a central registry, which may subsequently be linked to other data sources, require review by the institutional review board (IRB) of each participating organization? (3) What levels and mechanisms of IRB oversight are appropriate for the existence of a linked central data repository and the specific studies that may subsequently be developed using it? (4) Under what circumstances are waivers of informed consent and Health Insurance Portability and Accountability Act authorization required? (5) What are the requirements for a limited data set that would qualify a research activity as not involving human subjects and thus not subject to further IRB review? The approaches outlined in this article represent a local interpretation of the regulations in the context of several clinical data registry projects and focuses on a specific case study of the Society of Thoracic Surgeons National Database.

Home care robot for socially supporting the elderly: focus group studies in three European countries to screen user attitudes and requirements.

PubMed

Zsiga, Katalin; Edelmayer, Georg; Rumeau, Pierre; Péter, Orsolya; Tóth, András; Fazekas, Gábor

2013-12-01

The growing number of elderly individuals presents new challenges for society. Many elderly individuals have physical or cognitive impairments and require support from caregivers. An attempt to overcome the limitations caused by the lack of human caregivers is the inclusion of assistive technology such as socially active robots. The Domeo-project of the Ambient Assisted Living Joint Programme of the European Union aims to develop a new companion robotic system that would allow assistance to the elderly. The requirements and attitude of the potential users and caregivers have been assessed in Austria, France and Hungary. The robot functions were demonstrated to the participants. Three focus groups were formed: potential end users, older caregivers and younger caregivers. The discussions were recorded and processed according to six aspects: (i) acceptability and privacy, (ii) pertinence of services, (iii) possible obstacles, (iv) motivation level to use the proposed services, (v) organizational issues and (vi) recommendations. Minor differences were observed between the countries, but there were considerable differences regarding the age of the participants. The younger caregivers want to be assured of the safety of their client and to receive immediate notification in case of an emergency. As for the elderly, the most important aspect is to gain a companion and a physical helper. Many of the recommendations can be taken into consideration during robot development, but some of them are not realistic at present.

Toward the Decision Tree for Inferring Requirements Maturation Types

NASA Astrophysics Data System (ADS)

Nakatani, Takako; Kondo, Narihito; Shirogane, Junko; Kaiya, Haruhiko; Hori, Shozo; Katamine, Keiichi

Requirements are elicited step by step during the requirements engineering (RE) process. However, some types of requirements are elicited completely after the scheduled requirements elicitation process is finished. Such a situation is regarded as problematic situation. In our study, the difficulties of eliciting various kinds of requirements is observed by components. We refer to the components as observation targets (OTs) and introduce the word “Requirements maturation.” It means when and how requirements are elicited completely in the project. The requirements maturation is discussed on physical and logical OTs. OTs Viewed from a logical viewpoint are called logical OTs, e.g. quality requirements. The requirements of physical OTs, e.g., modules, components, subsystems, etc., includes functional and non-functional requirements. They are influenced by their requesters' environmental changes, as well as developers' technical changes. In order to infer the requirements maturation period of each OT, we need to know how much these factors influence the OTs' requirements maturation. According to the observation of actual past projects, we defined the PRINCE (Pre Requirements Intelligence Net Consideration and Evaluation) model. It aims to guide developers in their observation of the requirements maturation of OTs. We quantitatively analyzed the actual cases with their requirements elicitation process and extracted essential factors that influence the requirements maturation. The results of interviews of project managers are analyzed by WEKA, a data mining system, from which the decision tree was derived. This paper introduces the PRINCE model and the category of logical OTs to be observed. The decision tree that helps developers infer the maturation type of an OT is also described. We evaluate the tree through real projects and discuss its ability to infer the requirements maturation types.

Durability and Life of Ceramic Matrix Composites in Combustion Environment

NASA Technical Reports Server (NTRS)

Tewari, Surendra

1997-01-01

It is now generally recognized that the next frontier in the commercial air travel will be achieved by an optimum combination of the concepts being used for the air and space transports. It will depend upon the new engines specifically designed to meet the demanding strength, temperature, environment and economy requirements. The successful development of an advanced propulsion system for a 21st Century High Speed Civil Transport will require key advances in the combustor system. Minimizing nitrous oxide (NO(x)) emission is critical, since the deleterious interaction within the ozone layer would occur at the proposed vehicle cruise level of about 75,000 feet. In order to achieve the low NOx levels an efficient combustor operating at controlled equivalence ratios and high combustion temperatures are required. This requires a combustor, whose one portion will be operating in an oxidizing environment while the other portion will operate in a reducing environment. This rather unusual requirement has introduced considerable challenge to the materials scientists and engineers, the development of material systems capable of long-life at high temperatures (up to 3000 F) in an oxidizing and/or reducing environment.

Necrotizing pancreatitis: new definitions and a new era in surgical management.

PubMed

Rosenberg, Andrew; Steensma, Elizabeth A; Napolitano, Lena M

2015-02-01

Necrotizing pancreatitis is a challenging condition that requires surgical treatment commonly and is associated with substantial morbidity and mortality. Over the past decade, new definitions have been developed for standardization of severity of acute and necrotizing pancreatitis, and new management techniques have emerged based on prospective, randomized clinical trials. Review of English-language literature. A new international classification of acute pancreatitis has been developed by PANCREA (Pancreatitis Across Nations Clinical Research and Education Alliance) to replace the Atlanta Classification. It is based on the actual local (whether pancreatic necrosis is present or not, whether it is sterile or infected) and systemic determinants (whether organ failure is present or not, whether it is transient or persistent) of severity. Early management requires goal-directed fluid resuscitation (with avoidance of over-resuscitation and abdominal compartment syndrome), assessment of severity of pancreatitis, diagnostic computed tomography (CT) imaging to assess for necrotizing pancreatitis, consideration of endoscopic retrograde cholangiopancreatography (ERCP) for biliary pancreatitis and early enteral nutrition support. Antibiotic prophylaxis is not recommended. Therapeutic antibiotics are required for treatment of documented infected pancreatic necrosis. The initial treatment of infected pancreatic necrosis is percutaneous catheter or endoscopic (transgastric/transduodenal) drainage with a second drain placement as required. Lack of clinical improvement after these initial procedures warrants consideration of minimally invasive techniques for pancreatic necrosectomy including video-assisted retroperitoneal debridement (VARD), minimally invasive retroperitoneal pancreatectomy (MIRP), or transluminal direct endoscopic necrosectomy (DEN). Open necrosectomy is associated with substantial morbidity, but to date no randomized trial has documented superiority of either minimally invasive or open surgical technique. Additional trials are underway to address this. Severe acute and necrotizing pancreatitis requires a multi-disciplinary treatment strategy that must be individualized for each patient. Optimal treatment of necrotizing pancreatitis now requires a staged, multi-disciplinary, minimally invasive "step-up" approach that includes a team of interventional radiologists, therapeutic endoscopists, and surgeons.

The Transition from Spacecraft Development Ot Flight Operation: Human Factor Considerations

NASA Technical Reports Server (NTRS)

Basilio, Ralph R.

2000-01-01

In the field of aeronautics and astronautics, a paradigm shift has been witnessed by those in academia, research and development, and private industry. Long development life cycles and the budgets to support such programs and projects has given way to aggressive task schedules and leaner resources to draw from all the while challenging assigned individuals to create and produce improved products of processes. however, this "faster, better, cheaper" concept cannot merely be applied to the design, development, and test of complex systems such as earth-orbiting of interplanetary robotic spacecraft. Full advantage is not possible without due consideration and application to mission operations planning and flight operations, Equally as important as the flight system, the mission operations system consisting of qualified personnel, ground hardware and software tools, and verified and validated operational processes, should also be regarded as a complex system requiring personnel to draw upon formal education, training, related experiences, and heuristic reasoning in engineering an effective and efficient system. Unquestionably, qualified personnel are the most important elements of a mission operations system. This paper examines the experiences of the Deep Space I Project, the first in a series of new technology in-flight validation missions sponsored by the United States National Aeronautics and Space Administration (NASA), specifically, in developing a subsystems analysis and technology validation team comprised of former spacecraft development personnel. Human factor considerations are investigated from initial concept/vision formulation; through operational process development; personnel test and training; to initial uplink product development and test support. Emphasis has been placed on challenges and applied or recommended solutions, so as to provide opportunities for future programs and projects to address and disposition potential issues and concerns as early as possible to reap the benefits associated with learning from other's past experiences.

Geographic information system development in the CARETS project

USGS Publications Warehouse

Mitchell, William B.; Fegeas, Robin G.; Fitzpatrick, Katherine A.; Hallam, Cheryl A.

1977-01-01

Experience in the development of a geographic information system to support the CARETS project has confirmed the considerable advantages that may accrue by paralleling the system development with a rational and balanced system production effort which permits the integration of the education and training of users with interim deliverable products to them. Those advantages include support for a long-term staff plan that recognizes substantial staff changes through system development and implementation, a fiscal plan that provides continuity in resources necessary for total system development, and a feedback system which allows the user to communicate his experiences in using the system. Thus far balance between system development and system production has not been achieved because of continuing large-scale spatial data processing requirements coupled with strong and insistent demands from users for immediately deliverable products from the system. That imbalance has refocussed staffing and fiscal plans from long-term system development to short- and near-term production requirements, continuously extends total system development time, and increases the possibility that later system development may reduce the usefulness of current interim products.

Considerations for a business model for the effective integration of novel biomarkers into drug development.

PubMed

Frueh, Felix W

2008-11-01

It is 10 years since the introduction of trastuzumab into the US market, and we are still waiting for a validation of the business case for biomarker-driven drug development. While many reasons for the lack of duplication of this model may exist, the need for accelerated innovation in drug development paired with the opportunity of integrating biomarker-driven research into drug development programs may lead to new and creative ways of fostering the cooperation between drug developers and test manufacturers. The rapid increase in knowledge about biomarkers and our understanding of disease and disease mechanisms open unprecedented prospects to make not only better, more informed decisions regarding patient care, but also strategic decisions during drug development. This requires that a biomarker strategy becomes an integral part of (early) drug development and that new, innovative paths are tried towards a model that combines the scientific approach with an economically feasible implementation strategy. Collaborative research, the use of new communication tools, the exploration of alternative ways to position a product in the market, and other considerations are part of such a strategy. This perspective article illustrates the current landscape and takes a look at some of these new ways for more effectively integrating biomarkers into drug development.

Operating experiences with rotary air-to-air heat exchangers: hospitals, schools, nursing homes, swimming pools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pearson, R.J.

1976-01-01

Systems utilizing rotary air-to-air heat exchangers are discussed. Basic considerations of use (fresh air requirements, system configurations, cost considerations), typical system layout/design considerations, and operating observations by engineers, staff and maintenance personnel are described.

INCORPORATING WETLANDS IN WATER QUALITY TRADING: ECONOMIC CONSIDERATIONS (Journal Article)

EPA Science Inventory

Incorporating the use of wetlands as a technology to enhance water quality trading programs requires consideration of ecological, legal, and economic issues. We explore the case of encouraging the use of wetlands with a focus on the economic considerations. Interestingly, it is...

7 CFR 25.622 - Other considerations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

7 CFR 25.622 - Other considerations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

7 CFR 25.622 - Other considerations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

7 CFR 25.622 - Other considerations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

7 CFR 1735.92 - Accounting considerations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Accounting considerations. 1735.92 Section 1735.92... All Acquisitions and Mergers § 1735.92 Accounting considerations. (a) Proper accounting shall be... in the absence of such a commission, as required by RUS based on Generally Accepted Accounting...

17 CFR 39.27 - Legal risk considerations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... operations, risk management procedures, and related requirements. (c) Conflict of laws. If a derivatives... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Legal risk considerations. 39... CLEARING ORGANIZATIONS Compliance with Core Principles § 39.27 Legal risk considerations. (a) Legal...

17 CFR 39.27 - Legal risk considerations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... operations, risk management procedures, and related requirements. (c) Conflict of laws. If a derivatives... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Legal risk considerations. 39... CLEARING ORGANIZATIONS Compliance with Core Principles § 39.27 Legal risk considerations. (a) Legal...

7 CFR 25.622 - Other considerations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Other considerations. 25.622 Section 25.622 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.622 Other considerations. (a) Civil rights compliance requirements. All...

Electronics for Piezoelectric Smart Structures

NASA Technical Reports Server (NTRS)

Warkentin, D. J.; Tani, J.

1997-01-01

This paper briefly presents work addressing some of the basic considerations for the electronic components used in smart structures incorporating piezoelectric elements. After general remarks on the application of piezoelectric elements to the problem of structural vibration control, three main topics are described. Work to date on the development of techniques for embedding electronic components within structural parts is presented, followed by a description of the power flow and dissipation requirements of those components. Finally current work on the development of electronic circuits for use in an 'active wall' for acoustic noise is introduced.

System safety in Stirling engine development

NASA Technical Reports Server (NTRS)

Bankaitis, H.

1981-01-01

The DOE/NASA Stirling Engine Project Office has required that contractors make safety considerations an integral part of all phases of the Stirling engine development program. As an integral part of each engine design subtask, analyses are evolved to determine possible modes of failure. The accepted system safety analysis techniques (Fault Tree, FMEA, Hazards Analysis, etc.) are applied in various degrees of extent at the system, subsystem and component levels. The primary objectives are to identify critical failure areas, to enable removal of susceptibility to such failures or their effects from the system and to minimize risk.

Tunable Optical Filters for Space Exploration

NASA Technical Reports Server (NTRS)

Crandall, Charles; Clark, Natalie; Davis, Patricia P.

2007-01-01

Spectrally tunable liquid crystal filters provide numerous advantages and several challenges in space applications. We discuss the tradeoffs in design elements for tunable liquid crystal birefringent filters with special consideration required for space exploration applications. In this paper we present a summary of our development of tunable filters for NASA space exploration. In particular we discuss the application of tunable liquid crystals in guidance navigation and control in space exploration programs. We present a summary of design considerations for improving speed, field of view, transmission of liquid crystal tunable filters for space exploration. In conclusion, the current state of the art of several NASA LaRC assembled filters is presented and their performance compared to the predicted spectra using our PolarTools modeling software.

Navier-Stokes and viscous-inviscid interaction

NASA Technical Reports Server (NTRS)

Steger, Joseph L.; Vandalsem, William R.

1989-01-01

Some considerations toward developing numerical procedures for simulating viscous compressible flows are discussed. Both Navier-Stokes and boundary layer field methods are considered. Because efficient viscous-inviscid interaction methods have been difficult to extend to complex 3-D flow simulations, Navier-Stokes procedures are more frequently being utilized even though they require considerably more work per grid point. It would seem a mistake, however, not to make use of the more efficient approximate methods in those regions in which they are clearly valid. Ideally, a general purpose compressible flow solver that can optionally take advantage of approximate solution methods would suffice, both to improve accuracy and efficiency. Some potentially useful steps toward this goal are described: a generalized 3-D boundary layer formulation and the fortified Navier-Stokes procedure.

Description of the computations and pilot procedures for planning fuel-conservative descents with a small programmable calculator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vicroy, D.D.; Knox, C.E.

A simplified flight management descent algorithm was developed and programmed on a small programmable calculator. It was designed to aid the pilot in planning and executing a fuel conservative descent to arrive at a metering fix at a time designated by the air traffic control system. The algorithm may also be used for planning fuel conservative descents when time is not a consideration. The descent path was calculated for a constant Mach/airspeed schedule from linear approximations of airplane performance with considerations given for gross weight, wind, and nonstandard temperature effects. The flight management descent algorithm and the vertical performance modelingmore » required for the DC-10 airplane is described.« less

Autism Phenotypes in Tuberous Sclerosis Complex: Diagnostic and Treatment Considerations.

PubMed

Gipson, Tanjala T; Poretti, Andrea; Thomas, Emily A; Jenkins, Kosunique T; Desai, Sonal; Johnston, Michael V

2015-12-01

Tuberous sclerosis complex is a multisystem, chronic genetic condition characterized by systemic growth of benign tumors and often accompanied by epilepsy, autism spectrum disorders, and intellectual disability. Nonetheless, the neurodevelopmental phenotype of these patients is not often detailed. The authors describe 3 individuals with tuberous sclerosis complex who share common characteristics that can help to identify a distinct profile of autism spectrum disorder. These findings include typical cognitive development, expressive and pragmatic language deficits, and anxiety. The authors also describe features specific to tuberous sclerosis complex that require consideration before diagnosing an autism spectrum disorder. Identifying distinct profiles of autism spectrum disorder in tuberous sclerosis complex can help optimize treatment across the life span. © The Author(s) 2015.

Building an intellectual infrastructure for space commerce

NASA Technical Reports Server (NTRS)

Stone, Barbara A.; Struthers, Jeffrey L.

1992-01-01

Competition in commerce requires an 'intellectual infrastructure', that is, a work force with extensive scientific and technical knowledge and a thorough understanding of the business world. This paper focuses on the development of such intellectual infrastructure for space commerce. Special consideration is given to the contributions to this development by the 17 Centers for the Commercial Development of Space Program conducting commercially oriented research in eight specialized areas: automation and robotics, remote sensing, life sciences, materials processing in space, space power, space propulsion, space structures and materials, and advanced satellite communications. Attention is also given to the Space Business Development Center concept aimed at addressing a variety of barriers common to the development of space commerce.

Guidelines for the planning and preparation of illustrated technical talks

NASA Technical Reports Server (NTRS)

Hubbard, H. H.

1975-01-01

Guidelines are presented for the preparation of illustrated talks which are audience oriented and which are aimed at the efficient transfer of technical information. Early decisions concerning the required number of slides are helpful in initial planning for a good quality talk. Detailed considerations are: the establishment of limited objectives, selection of appropriate slide material, development of a text which is well coordinated with the slides, and accurate timing.

Cogeneration computer model assessment: Advanced cogeneration research study

NASA Technical Reports Server (NTRS)

Rosenberg, L.

1983-01-01

Cogeneration computer simulation models to recommend the most desirable models or their components for use by the Southern California Edison Company (SCE) in evaluating potential cogeneration projects was assessed. Existing cogeneration modeling capabilities are described, preferred models are identified, and an approach to the development of a code which will best satisfy SCE requirements is recommended. Five models (CELCAP, COGEN 2, CPA, DEUS, and OASIS) are recommended for further consideration.

Development of Genetic Markers for Environmental DNA (eDNA) Monitoring of Sturgeon

DTIC Science & Technology

2014-09-01

sturgeon markers were tested for specificity against a battery of 32 non-target fish species common to the Mississippi and Illinois River watersheds...techniques. Such methods, including fishing , netting, seining, and electrofishing, can often be logistically complex and require considerable outlays of... fish and amphibian community composition (Minamoto et al. 2012, Thomsen et al. 2012) and biomass estimation (Takahara et al. 2012). Sturgeon are taxa

A high resolution cavity BPM for the CLIC Test Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chritin, N.; Schmickler, H.; Soby, L.

2010-08-01

In frame of the development of a high resolution BPM system for the CLIC Main Linac we present the design of a cavity BPM prototype. It consists of a waveguide loaded dipole mode resonator and a monopole mode reference cavity, both operating at 15 GHz, to be compatible with the bunch frequencies at the CLIC Test Facility. Requirements, design concept, numerical analysis, and practical considerations are discussed.

The 406 MHz ELT/EPIRBs. [Emergency Locator Transmitters/Emergency Position Indicating Radio Beacons (ELT/EPIRB)

NASA Technical Reports Server (NTRS)

Flatow, F. S.; Gal, C.; Hayes, E. J.

1984-01-01

Specifications for the COSPAS/SARSAT beacons are presented and related design considerations are discussed. Critical design aspects having significant impact on cost and performance are highlighted. Among these is the oscillator, whose frequency drift specifications require stabilization by ovens or digital control. Design options are presented and their impact on cost and performance assessed. Beacon designs developed to meet COSPAS/SARSAT specifications are shown.

Computer-Based Instruction (CBI): Considerations for a User-Oriented Technology Data Base.

DTIC Science & Technology

1985-10-14

CBI works primarily because of the systematic attention to instructional material it brings to the development process , and the extent to which quality...looked at CBI software multi-use potential, support and maintenance from a joint service perspective, and described requirements for a software...computer support for some aspect of the instructional process . Personnel involved in other TDAC projects are reviewing commercially available CBI and

LSSA (Low-cost Silicon Solar Array) project

NASA Technical Reports Server (NTRS)

1976-01-01

Methods are explored for economically generating electrical power to meet future requirements. The Low-Cost Silicon Solar Array Project (LSSA) was established to reduce the price of solar arrays by improving manufacturing technology, adapting mass production techniques, and promoting user acceptance. The new manufacturing technology includes the consideration of new silicon refinement processes, silicon sheet growth techniques, encapsulants, and automated assembly production being developed under contract by industries and universities.

High Speed Exit Taxiways.

DTIC Science & Technology

1981-02-01

the runway with 1800 ft. radius and no specified runout distance, was developed circa 1958 and standardized in the 19609. A considerable nur, ber of...cornerinl) . Even wi th eaync);e wheel steering, the small fraction of total weight on thle nose whoel prevents tricycle airplaines from being very...would provide more runout but would require greater clearance travel distances at both Fnds. Z2 The results of reference (a) indicated that

Electronic laboratory notebook: the academic point of view.

PubMed

Rudolphi, Felix; Goossen, Lukas J

2012-02-27

Based on a requirement analysis and alternative design considerations, a platform-independent electronic laboratory notebook (ELN) has been developed that specifically targets academic users. Its intuitive design and numerous productivity features motivate chemical researchers and students to record their data electronically. The data are stored in a highly structured form that offers substantial benefits over laboratory notebooks written on paper with regard to data retrieval, data mining, and exchange of results.

Transportation Energy Futures Series: Vehicle Technology Deployment Pathways: An Examination of Timing and Investment Constraints

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plotkin, S.; Stephens, T.; McManus, W.

2013-03-01

Scenarios of new vehicle technology deployment serve various purposes; some will seek to establish plausibility. This report proposes two reality checks for scenarios: (1) implications of manufacturing constraints on timing of vehicle deployment and (2) investment decisions required to bring new vehicle technologies to market. An estimated timeline of 12 to more than 22 years from initial market introduction to saturation is supported by historical examples and based on the product development process. Researchers also consider the series of investment decisions to develop and build the vehicles and their associated fueling infrastructure. A proposed decision tree analysis structure could bemore » used to systematically examine investors' decisions and the potential outcomes, including consideration of cash flow and return on investment. This method requires data or assumptions about capital cost, variable cost, revenue, timing, and probability of success/failure, and would result in a detailed consideration of the value proposition of large investments and long lead times. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency effort to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.« less

Transportation Energy Futures Series. Vehicle Technology Deployment Pathways. An Examination of Timing and Investment Constraints

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plotkin, Steve; Stephens, Thomas; McManus, Walter

2013-03-01

Scenarios of new vehicle technology deployment serve various purposes; some will seek to establish plausibility. This report proposes two reality checks for scenarios: (1) implications of manufacturing constraints on timing of vehicle deployment and (2) investment decisions required to bring new vehicle technologies to market. An estimated timeline of 12 to more than 22 years from initial market introduction to saturation is supported by historical examples and based on the product development process. Researchers also consider the series of investment decisions to develop and build the vehicles and their associated fueling infrastructure. A proposed decision tree analysis structure could bemore » used to systematically examine investors' decisions and the potential outcomes, including consideration of cash flow and return on investment. This method requires data or assumptions about capital cost, variable cost, revenue, timing, and probability of success/failure, and would result in a detailed consideration of the value proposition of large investments and long lead times. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency effort to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.« less

Tesseract supersonic business transport

NASA Technical Reports Server (NTRS)

Reshotko, Eli; Garbinski, Gary; Fellenstein, James; Botting, Mary; Hooper, Joan; Ryan, Michael; Struk, Peter; Taggart, Ben; Taillon, Maggie; Warzynski, Gary

1992-01-01

This year, the senior level Aerospace Design class at Case Western Reserve University developed a conceptual design of a supersonic business transport. Due to the growing trade between Asia and the United States, a transpacific range was chosen for the aircraft. A Mach number of 2.2 was chosen, too, because it provides reasonable block times and allows the use of a large range of materials without a need for active cooling. A payload of 2,500 lbs. was assumed corresponding to a complement of nine passengers and crew, plus some light cargo. With these general requirements set, the class was broken down into three groups. The aerodynamics of the aircraft were the responsibility of the first group. The second developed the propulsion system. The efforts of both the aerodynamics and propulsion groups were monitored and reviewed for weight considerations and structural feasibility by the third group. Integration of the design required considerable interaction between the groups in the final stages. The fuselage length of the final conceptual design was 107.0 ft, while the diameter of the fuselage was 7.6 ft. The delta wing design consisted of an aspect ratio of 1.9 with a wing span of 47.75 ft and mid-chord length of 61.0 ft. A SNECMA MCV 99 variable-cycle engine design was chosen for this aircraft.

Tesseract: Supersonic business transport

NASA Technical Reports Server (NTRS)

Reshotko, Eli; Garbinski, Gary

1992-01-01

This year, the senior level Aerospace Design class at Case Western Reserve University developed a conceptual design of a supersonic business transport. Due to the growing trade between Asia and the United States, a transpacific range has been chosen for the aircraft. A Mach number of 2.2 was chosen too because it provides reasonable block times and allows the use of a large range of materials without a need for active cooling. A payload of 2500 lbs. has been assumed corresponding to a complement of nine (passengers and crew) plus some light cargo. With these general requirements set, the class was broken down into three groups. The aerodynamics of the aircraft were the responsibility of the first group. The second developed the propulsion system. The efforts of both the aerodynamics and propulsion groups were monitored and reviewed for weight considerations and structural feasibility by the third group. Integration of the design required considerable interaction between the groups in the final stages. The fuselage length of the final conceptual design was 107.0 ft. while the diameter of the fuselage was 7.6 ft. The delta wing design consisted of an aspect ratio of 1.9 with a wing span of 47.75 ft and midcord length of 61.0 ft. A SNEMCA MCV 99 variable-cycle engine design was chosen for this aircraft.

Considerations regarding the validation of chromatographic mass spectrometric methods for the quantification of endogenous substances in forensics.

PubMed

Hess, Cornelius; Sydow, Konrad; Kueting, Theresa; Kraemer, Michael; Maas, Alexandra

2018-02-01

The requirement for correct evaluation of forensic toxicological results in daily routine work and scientific studies is reliable analytical data based on validated methods. Validation of a method gives the analyst tools to estimate the efficacy and reliability of the analytical method. Without validation, data might be contested in court and lead to unjustified legal consequences for a defendant. Therefore, new analytical methods to be used in forensic toxicology require careful method development and validation of the final method. Until now, there are no publications on the validation of chromatographic mass spectrometric methods for the detection of endogenous substances although endogenous analytes can be important in Forensic Toxicology (alcohol consumption marker, congener alcohols, gamma hydroxy butyric acid, human insulin and C-peptide, creatinine, postmortal clinical parameters). For these analytes, conventional validation instructions cannot be followed completely. In this paper, important practical considerations in analytical method validation for endogenous substances will be discussed which may be used as guidance for scientists wishing to develop and validate analytical methods for analytes produced naturally in the human body. Especially the validation parameters calibration model, analytical limits, accuracy (bias and precision) and matrix effects and recovery have to be approached differently. Highest attention should be paid to selectivity experiments. Copyright © 2017 Elsevier B.V. All rights reserved.

Are Cocaine-Seeking "Habits" Necessary for the Development of Addiction-Like Behavior in Rats?

PubMed

Singer, Bryan F; Fadanelli, Monica; Kawa, Alex B; Robinson, Terry E

2018-01-03

Drug self-administration models of addiction typically require animals to make the same response (e.g., a lever-press or nose-poke) over and over to procure and take drugs. By their design, such procedures often produce behavior controlled by stimulus-response (S-R) habits. This has supported the notion of addiction as a "drug habit," and has led to considerable advances in our understanding of the neurobiological basis of such behavior. However, to procure such drugs as cocaine, addicts often require considerable ingenuity and flexibility in seeking behavior, which, by definition, precludes the development of habits. To better model drug-seeking behavior in addicts, we first developed a novel cocaine self-administration procedure [puzzle self-administration procedure (PSAP)] that required rats to solve a new puzzle every day to gain access to cocaine, which they then self-administered on an intermittent access (IntA) schedule. Such daily problem-solving precluded the development of S-R seeking habits. We then asked whether prolonged PSAP/IntA experience would nevertheless produce "symptoms of addiction." It did, including escalation of intake, sensitized motivation for drug, continued drug use in the face of adverse consequences, and very robust cue-induced reinstatement of drug seeking, especially in a subset of "addiction-prone" rats. Furthermore, drug-seeking behavior continued to require dopamine neurotransmission in the core of the nucleus accumbens (but not the dorsolateral striatum). We conclude that the development of S-R seeking habits is not necessary for the development of cocaine addiction-like behavior in rats. SIGNIFICANCE STATEMENT Substance-use disorders are often characterized as "habitual" behaviors aimed at obtaining and administering drugs. Although the actions involved in consuming drugs may involve a rigid repertoire of habitual behaviors, evidence suggests that addicts must be very creative and flexible when trying to procure drugs, and thus drug seeking cannot be governed by habit alone. We modeled flexible drug-seeking behavior in rats by requiring animals to solve daily puzzles to gain access to cocaine. We find that habitual drug-seeking isn't necessary for the development of addiction-like behavior, and that our procedure doesn't result in transfer of dopaminergic control from the ventral to dorsal striatum. This approach may prove useful in studying changes in neuropsychological function that promote the transition to addiction. Copyright © 2018 the authors 0270-6474/18/380060-14$15.00/0.

Electronic data capture in a rural African setting: evaluating experiences with different systems in Malawi.

PubMed

King, Carina; Hall, Jenny; Banda, Masford; Beard, James; Bird, Jon; Kazembe, Peter; Fottrell, Ed

2014-01-01

As hardware for electronic data capture (EDC), such as smartphones or tablets, becomes cheaper and more widely available, the potential for using such hardware as data capture tools in routine healthcare and research is increasing. We aim to highlight the advantages and disadvantages of four EDC systems being used simultaneously in rural Malawi: two for Android devices (CommCare and ODK Collect), one for PALM and Windows OS (Pendragon), and a custom-built application for Android (Mobile InterVA--MIVA). We report on the personal field and development experience of fieldworkers, project managers, and EDC system developers. Fieldworkers preferred using EDC to paper-based systems, although some struggled with the technology at first. Highlighted features include in-built skip patterns for all systems, and specifically the 'case' function that CommCare offers. MIVA as a standalone app required considerably more time and expertise than the other systems to create and could not be customised for our specific research needs; however, it facilitates standardised routine data collection. CommCare and ODK Collect both have user-friendly web-interfaces for form development and good technical support. CommCare requires Internet to build an application and download it to a device, whereas all steps can be done offline with ODK Collect, a desirable feature in low connectivity settings. Pendragon required more complex programming of logic, using a Microsoft Access application, and generally had less technical support. Start-up costs varied between systems, and all were considered more expensive than setting up a paper-based system; however running costs were generally low and therefore thought to be cost-effective over the course of our projects. EDC offers many opportunities for efficient data collection, but brings some issues requiring consideration when designing a study; the decision of which hardware and software to use should be informed by the aim of data collection, budget, and local circumstances.

Electronic data capture in a rural African setting: evaluating experiences with different systems in Malawi

PubMed Central

King, Carina; Hall, Jenny; Banda, Masford; Beard, James; Bird, Jon; Kazembe, Peter; Fottrell, Ed

2014-01-01

Background As hardware for electronic data capture (EDC), such as smartphones or tablets, becomes cheaper and more widely available, the potential for using such hardware as data capture tools in routine healthcare and research is increasing. Objective We aim to highlight the advantages and disadvantages of four EDC systems being used simultaneously in rural Malawi: two for Android devices (CommCare and ODK Collect), one for PALM and Windows OS (Pendragon), and a custom-built application for Android (Mobile InterVA – MIVA). Design We report on the personal field and development experience of fieldworkers, project managers, and EDC system developers. Results Fieldworkers preferred using EDC to paper-based systems, although some struggled with the technology at first. Highlighted features include in-built skip patterns for all systems, and specifically the ‘case’ function that CommCare offers. MIVA as a standalone app required considerably more time and expertise than the other systems to create and could not be customised for our specific research needs; however, it facilitates standardised routine data collection. CommCare and ODK Collect both have user-friendly web-interfaces for form development and good technical support. CommCare requires Internet to build an application and download it to a device, whereas all steps can be done offline with ODK Collect, a desirable feature in low connectivity settings. Pendragon required more complex programming of logic, using a Microsoft Access application, and generally had less technical support. Start-up costs varied between systems, and all were considered more expensive than setting up a paper-based system; however running costs were generally low and therefore thought to be cost-effective over the course of our projects. Conclusions EDC offers many opportunities for efficient data collection, but brings some issues requiring consideration when designing a study; the decision of which hardware and software to use should be informed by the aim of data collection, budget, and local circumstances. PMID:25363364

Analogy in causal inference: rethinking Austin Bradford Hill's neglected consideration.

PubMed

Weed, Douglas L

2018-05-01

The purpose of this article was to rethink and resurrect Austin Bradford Hill's "criterion" of analogy as an important consideration in causal inference. In epidemiology today, analogy is either completely ignored (e.g., in many textbooks), or equated with biologic plausibility or coherence, or aligned with the scientist's imagination. None of these examples, however, captures Hill's description of analogy. His words suggest that there may be something gained by contrasting two bodies of evidence, one from an established causal relationship, the other not. Coupled with developments in the methods of systematic assessments of evidence-including but not limited to meta-analysis-analogy can be restructured as a key component in causal inference. This new approach will require that a collection-a library-of known cases of causal inference (i.e., bodies of evidence involving established causal relationships) be developed. This library would likely include causal assessments by organizations such as the International Agency for Research on Cancer, the National Toxicology Program, and the United States Environmental Protection Agency. In addition, a process for describing key features of a causal relationship would need to be developed along with what will be considered paradigm cases of causation. Finally, it will be important to develop ways to objectively compare a "new" body of evidence with the relevant paradigm case of causation. Analogy, along with all other existing methods and causal considerations, may improve our ability to identify causal relationships. Copyright © 2018 Elsevier Inc. All rights reserved.

Considerations for conducting qualitative research with pediatric patients for the purpose of PRO development.

PubMed

Patel, Zabin S; Jensen, Sally E; Lai, Jin-Shei

2016-09-01

To provide an overview of methodological considerations when conducting qualitative research with pediatric patients for the purpose of patient-reported outcome measure development A literature review of qualitative methods in pediatric measure development was completed. Eight clinicians providing care to pediatric patients were interviewed for their expert input. Thematic analysis of the literature and clinician interviews was used to identify themes for consideration. Findings from the literature and expert interviews emphasized the way in which cognitive, linguistic, and social developmental factors affect pediatric patients' understanding of their condition and ability to communicate about their experiences in an interview. There was consensus among the experts that traditional semi-structured interviews with children younger than eight lack characteristics necessary to yield meaningful information about condition and symptom report because they may fail to capture children's understanding and awareness of their condition and may limit their ability to express themselves comfortably. Our findings include recommended strategies to optimize data collected in qualitative interviews with pediatric patients, including modifications to the interview process to establish rapport, construction of interview questions to ensure they are developmentally appropriate, and the use of supplementary techniques to facilitate communication. When employing qualitative methods in pediatric measure development, interview guides, methods, and length require careful tailoring to ensure the child's perspectives are captured. This may be best achieved through research performed with narrow age bands that employs flexibility in methods to allow children a comfortable way in which to communicate about their experiences.

7 CFR 1710.117 - Environmental considerations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Environmental considerations. 1710.117 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.117 Environmental considerations. Borrowers are required... Environmental Policy Act (NEPA), as amended (42 U.S.C. 4321 et seq.); the Council on Environmental Quality...

7 CFR 1710.117 - Environmental considerations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false Environmental considerations. 1710.117 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.117 Environmental considerations. Borrowers are required... Environmental Policy Act (NEPA), as amended (42 U.S.C. 4321 et seq.); the Council on Environmental Quality...

40 CFR 194.51 - Consideration of protected individual.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Consideration of protected individual... Individual and Ground-Water Protection Requirements § 194.51 Consideration of protected individual. Compliance assessments that analyze compliance with § 191.15 of this chapter shall assume that an individual...

40 CFR 194.52 - Consideration of exposure pathways.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Consideration of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 Consideration of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...

40 CFR 194.52 - Consideration of exposure pathways.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Consideration of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 Consideration of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...

40 CFR 194.52 - Consideration of exposure pathways.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Consideration of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 Consideration of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...

40 CFR 194.52 - Consideration of exposure pathways.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Consideration of exposure pathways. 194... Individual and Ground-Water Protection Requirements § 194.52 Consideration of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...

40 CFR 194.52 - Consideration of exposure pathways.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Consideration of exposure pathways... Individual and Ground-Water Protection Requirements § 194.52 Consideration of exposure pathways. In compliance assessments that analyze compliance with § 191.15 of this chapter, all potential exposure pathways...

Large numbers hypothesis. II - Electromagnetic radiation

NASA Technical Reports Server (NTRS)

Adams, P. J.

1983-01-01

This paper develops the theory of electromagnetic radiation in the units covariant formalism incorporating Dirac's large numbers hypothesis (LNH). A direct field-to-particle technique is used to obtain the photon propagation equation which explicitly involves the photon replication rate. This replication rate is fixed uniquely by requiring that the form of a free-photon distribution function be preserved, as required by the 2.7 K cosmic radiation. One finds that with this particular photon replication rate the units covariant formalism developed in Paper I actually predicts that the ratio of photon number to proton number in the universe varies as t to the 1/4, precisely in accord with LNH. The cosmological red-shift law is also derived and it is shown to differ considerably from the standard form of (nu)(R) - const.

Shaping a career trajectory in academic administration: leadership development for the deanship.

PubMed

Green, Alexia; Ridenour, Nancy

2004-11-01

The nursing profession continues to face many challenges, one of which is an insufficient number of aspiring leaders. The role of an academic leader, specifically that of dean, brings with it unique challenges and opportunities. Shaping a career in academic administration requires careful consideration of the leadership skills necessary to perform in this complex and challenging role. However, it is critical to the future of nursing as a profession that ample numbers of aspiring leaders can successfully make this transition. One can be better prepared to take on this exciting and rewarding leadership opportunity when one understands the challenges deans face, asks questions such as "Do I really want a deanship?," identifies the required leadership skills, defines a career trajectory and pathway, and develops the leadership skills necessary for deans.

Method of Optimizing the Construction of Machining, Assembly and Control Devices

NASA Astrophysics Data System (ADS)

Iordache, D. M.; Costea, A.; Niţu, E. L.; Rizea, A. D.; Babă, A.

2017-10-01

Industry dynamics, driven by economic and social requirements, must generate more interest in technological optimization, capable of ensuring a steady development of advanced technical means to equip machining processes. For these reasons, the development of tools, devices, work equipment and control, as well as the modernization of machine tools, is the certain solution to modernize production systems that require considerable time and effort. This type of approach is also related to our theoretical, experimental and industrial applications of recent years, presented in this paper, which have as main objectives the elaboration and use of mathematical models, new calculation methods, optimization algorithms, new processing and control methods, as well as some structures for the construction and configuration of technological equipment with a high level of performance and substantially reduced costs..

On the Development of a Hospital-Patient Web-Based Communication Tool: A Case Study From Norway.

PubMed

Granja, Conceição; Dyb, Kari; Bolle, Stein Roald; Hartvigsen, Gunnar

2015-01-01

Surgery cancellations are undesirable in hospital settings as they increase costs, reduce productivity and efficiency, and directly affect the patient. The problem of elective surgery cancellations in a North Norwegian University Hospital is addressed. Based on a three-step methodology conducted at the hospital, the preoperative planning process was modeled taking into consideration the narratives from different health professions. From the analysis of the generated process models, it is concluded that in order to develop a useful patient centered web-based communication tool, it is necessary to fully understand how hospitals plan and organize surgeries today. Moreover, process reengineering is required to generate a standard process that can serve as a tool for health ICT designers to define the requirements for a robust and useful system.

Suicide and the 'Poison Complex': Toxic Relationalities, Child Development, and the Sri Lankan Self-Harm Epidemic.

PubMed

Widger, Tom

2015-01-01

Suicide prevention efforts in Asia have increasingly turned to 'quick win' means restriction, while more complicated cognitive restriction and psychosocial programs are limited. This article argues the development of cognitive restriction programs requires greater consideration of suicide methods as social practices, and of how suicide cognitive schemata form. To illustrate this, the article contributes an ethnographically grounded study of how self-poisoning becomes cognitively available in Sri Lanka. I argue the overwhelming preference for poison as a method of self-harm in the country is not simply reflective of its widespread availability, but rather how cognitive schemata of poison-a 'poison complex'-develops from early childhood and is a precondition for suicide schemata. Limiting cognitive availability thus requires an entirely novel approach to suicide prevention that draws back from its immediate object (methods and causes of self-harm) to engage the wider poison complex of which suicide is just one aspect.

Modeling and simulation for space medicine operations: preliminary requirements considered

NASA Technical Reports Server (NTRS)

Dawson, D. L.; Billica, R. D.; McDonald, P. V.

2001-01-01

The NASA Space Medicine program is now developing plans for more extensive use of high-fidelity medical simulation systems. The use of simulation is seen as means to more effectively use the limited time available for astronaut medical training. Training systems should be adaptable for use in a variety of training environments, including classrooms or laboratories, space vehicle mockups, analog environments, and in microgravity. Modeling and simulation can also provide the space medicine development program a mechanism for evaluation of other medical technologies under operationally realistic conditions. Systems and procedures need preflight verification with ground-based testing. Traditionally, component testing has been accomplished, but practical means for "human in the loop" verification of patient care systems have been lacking. Medical modeling and simulation technology offer potential means to accomplish such validation work. Initial considerations in the development of functional requirements and design standards for simulation systems for space medicine are discussed.

New Automotive Air Conditioning System Simulation Tool Developed in MATLAB/Simulink

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kiss, T.; Chaney, L.; Meyer, J.

Further improvements in vehicle fuel efficiency require accurate evaluation of the vehicle's transient total power requirement. When operated, the air conditioning (A/C) system is the largest auxiliary load on a vehicle; therefore, accurate evaluation of the load it places on the vehicle's engine and/or energy storage system is especially important. Vehicle simulation software, such as 'Autonomie,' has been used by OEMs to evaluate vehicles' energy performance. A transient A/C simulation tool incorporated into vehicle simulation models would also provide a tool for developing more efficient A/C systems through a thorough consideration of the transient A/C system performance. The dynamic systemmore » simulation software Matlab/Simulink was used to develop new and more efficient vehicle energy system controls. The various modeling methods used for the new simulation tool are described in detail. Comparison with measured data is provided to demonstrate the validity of the model.« less

Money or your life? The health-wealth trade-off in pharmaceutical regulation.

PubMed

Maynard, A; Cookson, R

2001-07-01

For decades the development of pharmaceuticals has been regulated by safety, efficacy and quality rules for product registration. In public health care systems, these three 'hurdles' are increasingly being supplemented by a fourth: the mandatory requirement to demonstrate economic efficiency in order to obtain reimbursement. This requirement challenges the wealth creation ethic of industry (money) with the population health ethic of public health and health economics (your life). Despite practical and methodological obstacles to the use of economic evidence in decisions, the logic of this development is evident: in order to maximise improvements in population health, scarce resources must be targeted towards developing and applying technologies that deliver the greatest health gains per unit cost. The impact of this policy change on industry practice and profits will be considerable, and companies that fail to demonstrate the economic efficiency of their products will stumble at the fourth hurdle.

Autonomous flight and remote site landing guidance research for helicopters

NASA Technical Reports Server (NTRS)

Denton, R. V.; Pecklesma, N. J.; Smith, F. W.

1987-01-01

Automated low-altitude flight and landing in remote areas within a civilian environment are investigated, where initial cost, ongoing maintenance costs, and system productivity are important considerations. An approach has been taken which has: (1) utilized those technologies developed for military applications which are directly transferable to a civilian mission; (2) exploited and developed technology areas where new methods or concepts are required; and (3) undertaken research with the potential to lead to innovative methods or concepts required to achieve a manual and fully automatic remote area low-altitude and landing capability. The project has resulted in a definition of system operational concept that includes a sensor subsystem, a sensor fusion/feature extraction capability, and a guidance and control law concept. These subsystem concepts have been developed to sufficient depth to enable further exploration within the NASA simulation environment, and to support programs leading to the flight test.

A development framework for artificial intelligence based distributed operations support systems

NASA Technical Reports Server (NTRS)

Adler, Richard M.; Cottman, Bruce H.

1990-01-01

Advanced automation is required to reduce costly human operations support requirements for complex space-based and ground control systems. Existing knowledge based technologies have been used successfully to automate individual operations tasks. Considerably less progress has been made in integrating and coordinating multiple operations applications for unified intelligent support systems. To fill this gap, SOCIAL, a tool set for developing Distributed Artificial Intelligence (DAI) systems is being constructed. SOCIAL consists of three primary language based components defining: models of interprocess communication across heterogeneous platforms; models for interprocess coordination, concurrency control, and fault management; and for accessing heterogeneous information resources. DAI applications subsystems, either new or existing, will access these distributed services non-intrusively, via high-level message-based protocols. SOCIAL will reduce the complexity of distributed communications, control, and integration, enabling developers to concentrate on the design and functionality of the target DAI system itself.

22 CFR 513.311 - Investigation and referral.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Debarment § 513.311... consideration. After consideration, the debarring official may issue a notice of proposed debarment. ...

22 CFR 513.410 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Suspension § 513.410 Procedures. (a) Investigation... consideration. After consideration, the suspending official may issue a notice of suspension. (b) Decisionmaking...

EU Regulation of Nanobiocides: Challenges in Implementing the Biocidal Product Regulation (BPR).

PubMed

Brinch, Anna; Hansen, Steffen Foss; Hartmann, Nanna B; Baun, Anders

2016-02-16

The Biocidal Products Regulation (BPR) contains several provisions for nanomaterials (NMs) and is the first regulation in the European Union to require specific testing and risk assessment for the NM form of a biocidal substance as a part of the information requirements. Ecotoxicological data are one of the pillars of the information requirements in the BPR, but there are currently no standard test guidelines for the ecotoxicity testing of NMs. The overall objective of this work was to investigate the implications of the introduction of nano-specific testing requirements in the BPR and to explore how these might be fulfilled in the case of copper oxide nanoparticles. While there is information and data available in the open literature that could be used to fulfill the BPR information requirements, most of the studies do not take the Organisation for Economic Co-operation and Development's nanospecific test guidelines into consideration. This makes it difficult for companies as well as regulators to fulfill the BPR information requirements for nanomaterials. In order to enable a nanospecific risk assessment, best practices need to be developed regarding stock suspension preparation and characterization, exposure suspensions preparation, and for conducting ecotoxicological test.

Space solar power. Description of concept, results of preliminary studies, requirements for evaluation

NASA Technical Reports Server (NTRS)

1977-01-01

The nation is actively pursuing alternate sources of energy because of the problems or concerns related to obtaining required energy for the future from oil, gas, nuclear, and coal sources. Solar energy is an obvious candidate for consideration. Its use in the past has been limited by the relative cost of collecting and converting solar energy into electrical power. The increasing costs of other energy sources will make solar energy more attractive. During recent years a new concept for the collection of solar energy has been developed. This concept involves the location of solar power stations in space. The concept, results of preliminary studies, and requirements for space evaluation of such a project are discussed.

Design definition of the Laser Atmospheric Wind Sounder (LAWS), phase 2. Volume 2: Final report

NASA Technical Reports Server (NTRS)

Wilson, D. J.

1992-01-01

Lockheed personnel, along with team member subcontractors and consultants, have performed a preliminary design for the LAWS Instrument. Breadboarding and testing of a LAWS class laser have also been performed. These efforts have demonstrated that LAWS is a feasible Instrument and can be developed with existing state-of-the-art technology. Only a commitment to fund the instrument development and deployment is required to place LAWS in orbit and obtain the anticipated science and operational forecasting benefits. The LAWS Science Team was selected in 1988-89 as were the competing LAWS phase 1/2 contractor teams. The LAWS Science Team developed requirements for the LAWS Instrument, and the NASA/LAWS project office defined launch vehicle and platform design constraints. From these requirements and constraints, the lockheed team developed LAWS Instrument concepts and configurations. A system designed to meet these requirements and constraints is outlined. The LAWS primary subsystem and interfaces - laser, optical, and receiver/processor - required to assemble a lidar are identified. Also identified are the support subsystems required for the lidar to function from space: structures and mechanical, thermal, electrical, and command and data management. The Lockheed team has developed a preliminary design of a LAWS Instrument System consisting of these subsystems and interfaces which will meet the requirements and objectives of the Science Team. This final report provides a summary of the systems engineering analyses and trades of the LAWS. Summaries of the configuration, preliminary designs of the subsystems, testing recommendations, and performance analysis are presented. Environmental considerations associated with deployment of LAWS are discussed. Finally, the successful LAWS laser breadboard effort is discussed along with the requirements and test results.

Study on the feasibility of provision of distance learning programmes in surgery to Malawi.

PubMed

Mains, Edward A A; Blackmur, James P; Dewhurst, David; Ward, Ross M; Garden, O James; Wigmore, Stephen J

2011-12-01

Medical educational opportunities and resources are considerably limited in the developing world. The expansion of computing and Internet access means that there exists a potential to provide education to students through distance learning programmes. This study investigated the feasibility of providing distance learning course in surgery in Malawi. The study investigated the user requirements, technical requirements and Internet connections in two teaching hospitals in Malawi. In addition the appropriateness of current course material from the Edinburgh Surgical Sciences Qualification to Malawi trainees was assessed. The study found a high degree of interest from Malawian trainees in distance learning. The provision of basic science modules such as anatomy and physiology and the ability to access journals were considered highly desirable. The current ESSQ course would require extensive re-modelling to make it suitable to an African trainee's requirements. Internet speeds remain slow and access is currently expensive. There is considerable interest in distance learning programmes in Malawi but access to them is limited partly because of slow and expensive Internet access. Understanding the needs of trainees in countries such as Malawi will allow better direction of educational aid and resources to support surgical training. Copyright © 2010 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

Helping System Engineers Bridge the Peaks

NASA Technical Reports Server (NTRS)

Rungta, Neha; Tkachuk, Oksana; Person, Suzette; Biatek, Jason; Whalen, Michael W.; Castle, Joseph; Castle, JosephGundy-Burlet, Karen

2014-01-01

In our experience at NASA, system engineers generally follow the Twin Peaks approach when developing safety-critical systems. However, iterations between the peaks require considerable manual, and in some cases duplicate, effort. A significant part of the manual effort stems from the fact that requirements are written in English natural language rather than a formal notation. In this work, we propose an approach that enables system engineers to leverage formal requirements and automated test generation to streamline iterations, effectively "bridging the peaks". The key to the approach is a formal language notation that a) system engineers are comfortable with, b) is supported by a family of automated V&V tools, and c) is semantically rich enough to describe the requirements of interest. We believe the combination of formalizing requirements and providing tool support to automate the iterations will lead to a more efficient Twin Peaks implementation at NASA.

49 CFR 209.329 - Assessment considerations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... frequently repeated; (2) The adverse impact or the potentially adverse impact of the violation on the health... 49 Transportation 4 2010-10-01 2010-10-01 false Assessment considerations. 209.329 Section 209.329... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of parts...

49 CFR 209.329 - Assessment considerations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... frequently repeated; (2) The adverse impact or the potentially adverse impact of the violation on the health... 49 Transportation 4 2014-10-01 2014-10-01 false Assessment considerations. 209.329 Section 209.329... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of parts...