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Sample records for rer nat thesis

  1. ISCCP TOVS NAT

    Atmospheric Science Data Center

    2016-02-12

    ISCCP TOVS NAT Atmospheric Profiles, NATIVE file format Project Title:  ...   Parameters:  Cloud Amount Cloud Top Pressure Ozone Precipitable Water Profiles Surface Pressure Surface Temperature Temperature Profiles Tropopause Pressure ...

  2. Friedman's thesis

    NASA Astrophysics Data System (ADS)

    Samaroo, Ryan

    2015-11-01

    This essay examines Friedman's recent approach to the analysis of physical theories. Friedman argues against Quine that the identification of certain principles as 'constitutive' is essential to a satisfactory methodological analysis of physics. I explicate Friedman's characterization of a constitutive principle, and I evaluate his account of the constitutive principles that Newtonian and Einsteinian gravitation presuppose for their formulation. I argue that something close to Friedman's thesis is defensible.

  3. NAT THE RAT - PUPIL'S BOOK. (TITLE SUPPLIED).

    ERIC Educational Resources Information Center

    ROJAS, PAULINE M.; AND OTHERS

    THE EXPERIMENTAL EDITION OF "NAT THE RAT" REPRESENTS LEVEL TWO OF THE "MIAMI LINGISTIC READERS" DESIGNED TO BE USED IN TEACHING BEGINNING READING TO PUPILS WHOSE PRESCHOOL LANGUAGE WAS OTHER THAN ENGLISH. THE FIVE MAJOR CHARACTERS IN THE STORY ARE INTRODUCED ON THE FIRST FIVE PAGES OF THE PUPILS' BOOK. ILLUSTRATIONS (BLACK AND…

  4. The discovery and significance of NAT particles

    NASA Astrophysics Data System (ADS)

    Mauersberger, K.

    2003-04-01

    Shortly after the discovery of the ozone hole, stratospheric and laboratory research focused on the existence of particles above the frost point. Predictions were made that nitric acid and water can co-condense to form a stable hydrate. Thermodynamic properties of such a hydrate were measured with high precision in laboratory studies on macroscopic substrates. Indeed, for stratospheric partial pressures of HNO_3 and H_2O and low temperatures NAT particles should exist 5 to 7^oC above the frost point. NO_y measurements within the south polar vortex confirmed the predictions based on those results. Ten years have passed before particles with NAT molar ratios of 3 were actually measured above Scandinavia. In between, strong evidence from field experiments and theoretical studies emerged that showed the preferred existence of liquid particles whose range is lower and narrower in temperature. NAT particles are crucial for explaining the large ozone losses in the temperature-sensitive northern polar stratosphere. No other known particle can be present at such high temperatures and can grow to transport reactive nitrogen out of the polar lower stratosphere.

  5. Teaching the Thesis

    ERIC Educational Resources Information Center

    Carroll, Joyce Armstrong

    2012-01-01

    Writing a good thesis provides a successful foundation for composing an essay. Teaching how to do that, however, is quite another matter. Teachers often say to students, "Find a thesis," or "Get a thesis," or "Bring in a thesis statement tomorrow," as if students could order one like a pizza, command it like a pet pooch, or grasp one out of thin…

  6. Using Albrecht Dürer's "Instruction on Measurement" for Projects in the Mathematics Classroom

    ERIC Educational Resources Information Center

    Tamulis, Andrius

    2014-01-01

    Albrecht Dürer is well known as a Renaissance artist, but his 1525 work, the "Underweysung der Messung," or "Manual on Measurement," also contains a significant amount of mathematics. This article outlines four projects inspired by parts of this work, with additional material coming from Staigmüller's 1891 "Dürer als…

  7. Laboratory simulations of NAT formation approaching stratospheric conditions

    NASA Technical Reports Server (NTRS)

    Marti, James; Mauersberger, Konrad

    1994-01-01

    Previous laboratory studies have established the stability conditions of nitric acid trihydrate (NAT), of which type 1 polar stratospheric cloud (PSC 1) particles are thought to be composed. However, NAT samples in lab studies were almost always formed under conditions very different from those of the stratosphere. In order to better understand the in situ growth of PSC 1 particle populations, samples of water and nitric acid were deposited under conditions of temperature and pressure which more closely approximate the polar stratosphere. The compositions of the solids, measured shortly after deposition, depended on the H2O:HNO3 ratio in the vapor from which the solids were condensed. Solids formed from vapor mixtures that approached stratospheric contained significantly less HNO3 than the 25 mol percent expected of NAT.

  8. The Tractable Cognition Thesis

    ERIC Educational Resources Information Center

    van Rooij, Iris

    2008-01-01

    The recognition that human minds/brains are finite systems with limited resources for computation has led some researchers to advance the "Tractable Cognition thesis": Human cognitive capacities are constrained by computational tractability. This thesis, if true, serves cognitive psychology by constraining the space of computational-level theories…

  9. The tractable cognition thesis.

    PubMed

    Van Rooij, Iris

    2008-09-01

    The recognition that human minds/brains are finite systems with limited resources for computation has led some researchers to advance the Tractable Cognition thesis: Human cognitive capacities are constrained by computational tractability. This thesis, if true, serves cognitive psychology by constraining the space of computational-level theories of cognition. To utilize this constraint, a precise and workable definition of "computational tractability" is needed. Following computer science tradition, many cognitive scientists and psychologists define computational tractability as polynomial-time computability, leading to the P-Cognition thesis. This article explains how and why the P-Cognition thesis may be overly restrictive, risking the exclusion of veridical computational-level theories from scientific investigation. An argument is made to replace the P-Cognition thesis by the FPT-Cognition thesis as an alternative formalization of the Tractable Cognition thesis (here, FPT stands for fixed-parameter tractable). Possible objections to the Tractable Cognition thesis, and its proposed formalization, are discussed, and existing misconceptions are clarified.

  10. The Faces of Saturn: Images and Texts from Augustus through Dürer to Galileo

    NASA Astrophysics Data System (ADS)

    Shank, M. H.

    2013-04-01

    This paper follows the thread(s) of Saturn in astrology and art from the Babylonians to Galileo, paying special attention to the planet's political importance from Augustus to the Medici and to its medical/psychological significance from Ficino through Dürer. In passing, I extend David Pingree's astrological interpretation of Dürer's Melencholia I and propose a very personal rationale for the engraving, namely as a memorial to his mother.

  11. Degree by Thesis

    ERIC Educational Resources Information Center

    Courtis, Barbara

    1974-01-01

    Discusses a student's experience with a research project on the synthesis and reactions of an organo-platinum complex with an organo-Group IV linkage, including the advantages and disadvantages of such a degree by thesis course. (CC)

  12. PlantNATsDB: a comprehensive database of plant natural antisense transcripts

    PubMed Central

    Chen, Dijun; Yuan, Chunhui; Zhang, Jian; Zhang, Zhao; Bai, Lin; Meng, Yijun; Chen, Ling-Ling; Chen, Ming

    2012-01-01

    Natural antisense transcripts (NATs), as one type of regulatory RNAs, occur prevalently in plant genomes and play significant roles in physiological and pathological processes. Although their important biological functions have been reported widely, a comprehensive database is lacking up to now. Consequently, we constructed a plant NAT database (PlantNATsDB) involving approximately 2 million NAT pairs in 69 plant species. GO annotation and high-throughput small RNA sequencing data currently available were integrated to investigate the biological function of NATs. PlantNATsDB provides various user-friendly web interfaces to facilitate the presentation of NATs and an integrated, graphical network browser to display the complex networks formed by different NATs. Moreover, a ‘Gene Set Analysis’ module based on GO annotation was designed to dig out the statistical significantly overrepresented GO categories from the specific NAT network. PlantNATsDB is currently the most comprehensive resource of NATs in the plant kingdom, which can serve as a reference database to investigate the regulatory function of NATs. The PlantNATsDB is freely available at http://bis.zju.edu.cn/pnatdb/. PMID:22058132

  13. The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels

    PubMed Central

    Valkova, Christina; Liebmann, Lutz; Krämer, Andreas; Hübner, Christian A.; Kaether, Christoph

    2017-01-01

    Rer1 is a sorting receptor in the early secretory pathway that controls the assembly and the cell surface transport of selected multimeric membrane protein complexes. Mice with a Purkinje cell (PC) specific deletion of Rer1 showed normal polarization and differentiation of PCs and normal development of the cerebellum. However, PC-specific loss of Rer1 led to age-dependent motor deficits in beam walk, ladder climbing and gait. Analysis of brain sections revealed a specific degeneration of PCs in the anterior cerebellar lobe in old animals. Electrophysiological recordings demonstrated severe deficits in spontaneous action potential generation. Measurements of resurgent currents indicated decreased surface densities of voltage-gated sodium channels (Nav), but not changes in individual channels. Analysis of mice with a whole brain Rer1-deletion demonstrated a strong down-regulation of Nav1.6 and 1.1 in the absence of Rer1, whereas protein levels of the related Cav2.1 and of Kv3.3 and 7.2 channels were not affected. The data suggest that Rer1 controls the assembly and transport of Nav1.1 and 1.6, the principal sodium channels responsible for recurrent firing, in PCs. PMID:28117367

  14. VO2@RER1.0: a novel submaximal cardiopulmonary exercise index.

    PubMed

    Chin, Clifford; Kazmucha, Jeffrey; Kim, Nancy; Suryani, Reny; Olson, Inger

    2010-01-01

    Maximal oxygen consumption (VO2max) is the "gold standard" by which to assess functional capacity; however, it is effort dependent. VO2@RER1.0 is defined when VO2 = VCO2. Between December 22, 1997 and November 9, 2004, 305 pediatric subjects underwent cycle ergometer cardiopulmonary exercise testing, exercised to exhaustion, and reached a peak respiratory exchange ratio > or = 1.10. Group 1 subjects achieved a peak VO2 > or = 80% of predicted VO2max; group 2 subjects achieved a peak VO2 < or = 60% of predicted VO2max; and group 3 subjects achieved a peak VO2 between 61 and 79% of predicted VO2max. Linear regression analysis was performed for VO2@RER1.0 as a function of predicted VO2 for group 1 subjects. A -2 SD regression line and equation was created. VO2@RER1.0 data from groups 2 and 3 were plotted onto the normative graph. Contingency table and relative-risk analysis showed that an abnormal VO2@RER1.0 predicted an abnormal peak VO2(positive-predictive value 83%, negative-predictive value 85%, sensitivity 84%, and specificity 84%). VO2@RER1.0 is a highly sensitive, specific, and predictive submaximal index of functional capacity. This submaximal index is easy to identify without subjectivity. This index may aid in the evaluation of subjects who cannot exercise to maximal parameters.

  15. The Las Vegas Thesis

    ERIC Educational Resources Information Center

    Sughrua, William

    2010-01-01

    Following "reflexive ethnography" and utilizing an approach of "performative narrative" and "layered text", this article explores how Bachelor of Arts students in the Teaching of English as a Foreign Language program at a public university in Mexico successfully manage the writing of an inductive-oriented thesis in…

  16. Going beyond the Thesis

    ERIC Educational Resources Information Center

    Smith, Andrew C.

    2010-01-01

    Most every writing teacher can relate to the curse of reading yet another incoherent essay, the contents of which resemble an unorganized junk drawer of thoughts. Such essays cry out for a main idea. The remedy is a thesis, and teachers rightly take pains to help students discover this. Yet in spite of this, writing teachers ought to bear in mind…

  17. Writing a Thesis Differently

    ERIC Educational Resources Information Center

    Honan, Eileen; Bright, David

    2016-01-01

    In this paper we explore the contributions that Deleuze and Guattari have made to thinking/writing language and how these ideas can be put to work in producing a doctoral thesis. We contribute to the field of work within what Patti Lather and Elizabeth St Pierre have called the "post-qualitative" movement, where researchers attempt to…

  18. Production cross section of At radionuclides from 7Li+natPb and 9Be+natTl reactions

    NASA Astrophysics Data System (ADS)

    Maiti, Moumita; Lahiri, Susanta

    2011-12-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from 6,7Li- and 9Be-induced reactions on natural lead and thallium targets, respectively. The production of astatine radionuclides were investigated experimentally with two heavy-ion-induced reactions: 9Be + natTl and 7Li + natPb. Formation cross sections of the evaporation residues, 207,208,209,210At, produced in the (HI,xn) channel, were measured by the stacked-foil technique followed by off-line γ spectrometry at low incident energies (<50 MeV). Measured excitation functions were interpreted in terms of a compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach models. Measured cross-section values are lower than the respective theoretical predictions.

  19. Towards A Quantitative Understanding of Nat Formation and Its Impact On Denitrification and Polar Ozone

    NASA Astrophysics Data System (ADS)

    Peter, Th.; Luo, B. P.; Fuglistaler, S.; Knopf, D.; Koop, T.; Buss, S.; Wernli, H.; Voigt, C.

    NAT (nitric acid trihydrate) particles play two important roles in polar ozone chem- istry: (i) heterogeneous reactions on their surface leads to activation of chlorine species, and (ii) sedimentation of large NAT particles may lead to denitrification and thus enhancement of chlorine-catalysed ozone depletion. Despite enormous labora- tory, field and modelling efforts, the formation of NAT particles is still highly contro- versial. While there is indication that small NAT particles at high number density, as observed downstream of ice clouds in mountain waves, might be explained as hetero- geneous NAT nucleation on ice, there is no precise understanding of the microphysics behind this process. Matters are complicated by the fact that ice nucleation, itself sub- ject to strong supercooling, requires a precision in temperature currently not provided by weather forecast models. The origin of large NAT particles at low number concen- trations, so-called NAT rocks, is even more uncertain. There is, however, laboratory evidence against homogeneous nucleation of NAT from supercooled solution droplets. While heterogeneous nucleation is in principle a possible pathway for NAT formation, there is observation-based modelling work suggesting that large NAT particles could be generated from high number density NAT clouds (mother clouds). The potential for predictions of denitrification in a colder future stratosphere will be discussed.

  20. Association between polymorphisms at N-acetyltransferase 1 (NAT1) & risk of oral leukoplakia & cancer

    PubMed Central

    Majumder, Mousumi; Ghosh, Saurabh; Roy, Bidyut

    2012-01-01

    Background & objectives: N-acetyltransferases 1 and 2 (NAT1 and NAT2) are important enzymes for metabolism of tobacco carcinogens. Due to polymorphisms, improper activities of these enzymes might lead to the formation of DNA adducts that may modulate risk of tobacco related oral precancer and cancer. Previously, it was shown that NAT2 polymorphisms did not modulate the risk of oral precancer and cancer. We undertook this study to check whether polymorphisms at NAT1 can modulate the risk of oral leukoplakia and cancer either alone or in combination with NAT2. Methods: Genotypes at four SNPs on NAT1 were determined by TaqMan method in 389 controls, 224 leukoplakia and 310 cancer patients. Genotype data were analyzed to know haplotypes and acetylation status of individuals and, then to estimate the risk of diseases. Using our previously published NAT2 data, combination of NAT1 and NAT2 acetylation genotypes of patients and controls were also analyzed to estimate the risk of diseases. Results: Analysis of NAT1 genotype data revealed that 1088T and 1095C alleles exist in strong linkage disequilibrium (r2=0.97, P<0.0001) and SNPs are in Hardy-Weinberg Equilibrium (P=0.1). Wild type or normal acetylating and variant or rapid acetylating alleles were two major alleles (frequencies 0.62 and 0.36, respectively) present in the control population. NAT1 rapid acetylation could not modulate the risk of leukoplakia and cancer (OR=0.9, 95% CI: 0.6-1.3; OR=1.0, 95% CI: 0.7-1.4, respectively). Analysis of combined NAT1 and NAT2 acetylating data also showed no significant enhancement of the risk of diseases. Interpretation & conclusions: NAT1 rapid acetylation alone as well as combination of NAT1 rapid-NAT2 slow acetylation did not modulate the risk of oral precancer and cancer in our patient population. So, NAT1/NAT2 metabolized carcinogen products may not be involved in tobacco related oral precancer and cancer. It may be interpreted that large sample size as well as combination of

  1. NAT2 gene diversity and its evolutionary trajectory in the Americas.

    PubMed

    Bisso-Machado, R; Ramallo, V; Paixão-Côrtes, V R; Acuña-Alonzo, V; Demarchi, D A; Sandoval, J R S; Granara, A A S; Salzano, F M; Hünemeier, T; Bortolini, M C

    2016-11-01

    N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native American and American Mestizos). Excluding the basal/rapid haplotype NAT2*4, the most frequent haplotypes are NAT2*5B (35.95%) in hunter-gatherers and NAT2*7B (20.61%) and NAT2*5B (19.08%) in agriculturalists that were related to the slow phenotype. A new haplotype was identified in two Amerindians. Data from the ~44 kb region surrounding NAT2 in 819 individuals from Africa, East-Asia, Europe and America were used in additional analyses. No significant differences in the acetylator NAT2 haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering, probably because of the absence or weakness of selection pressures and presence of demographic and random processes preventing detection of any selection signal.

  2. Global analysis of cis-natural antisense transcripts and their heat-responsive nat-siRNAs in Brassica rapa

    PubMed Central

    2013-01-01

    Background Brassica rapa includes several important leaf vegetable crops whose production is often damaged by high temperature. Cis-natural antisense transcripts (cis-NATs) and cis-NATs-derived small interfering RNAs (nat-siRNAs) play important roles in plant development and stress responses. However, genome-wide cis-NATs in B. rapa are not known. The NATs and nat-siRNAs that respond to heat stress have never been well studied in B. rapa. Here, we took advantage of RNA-seq and small RNA (sRNA) deep sequencing technology to identify cis-NATs and heat responsive nat-siRNAs in B. rapa. Results Analyses of four RNA sequencing datasets revealed 1031 cis-NATs B. rapa ssp. chinensis cv Wut and B. rapa ssp. pekinensis cv. Bre. Based on sequence homology between Arabidopsis thaliana and B. rapa, 303 conserved cis-NATs in B. rapa were found to correspond to 280 cis-NATs in Arabidopsis; the remaining 728 novel cis-NATs were identified as Brassica-specific ones. Using six sRNA libraries, 4846 nat-siRNAs derived from 150 cis-NATs were detected. Differential expression analysis revealed that nat-siRNAs derived from 12 cis-NATs were responsive to heat stress, and most of them showed strand bias. Real-time PCR indicated that most of the transcripts generating heat-responsive nat-siRNAs were upregulated under heat stress, while the transcripts from the opposite strands of the same loci were downregulated. Conclusions Our results provide the first subsets of genome-wide cis-NATs and heat-responsive nat-siRNAs in B. rapa; these sRNAs are potentially useful for the genetic improvement of heat tolerance in B. rapa and other crops. PMID:24320882

  3. [Viral safety of biologicals: evaluation of hepatitis C virus (HCV) nucleic acid amplification test (NAT) assay and development of concentration method of HCV for sensitive detection by NAT].

    PubMed

    Uchida, Eriko; Yamaguchi, Teruhide

    2010-02-01

    The most important issue for the safety of biological products and blood products derived from human sources is how to prevent transmission of infectious agents. The hepatitis C virus (HCV) is a major public health problem due to its high prevalence. HCV is mainly transmitted by exposure to blood and highly infectious during the early window period with extremely low viral loads. Therefore it is important to develop more sensitive detection methods for HCV. In the case of blood products, both serological test and nucleic acid amplification test (NAT) are required to detect HCV. Since NAT is highly sensitive, establishment of a new standard is required for validation of NAT assay. NAT guideline and establishment of the standard for HCV RNA and HCV genotype panel is introduced in this review. On the other hand, to enhance the sensitivity of virus detection by NAT, a novel viral concentration method using polyethyleneimine (PEI)-conjugated magnetic beads (PEI beads) was developed. PEI beads concentration method is applicable to a wide range of viruses including HCV. Studies using the national standard for HCV RNA, HCV genotype panel and seroconversion panel, suggest that virus concentration method using PEI-beads is useful for improvement of the sensitivity of HCV detection by NAT and applicable to donor screening for HCV.

  4. A Study Guide for Stephen B. Oates' "The Fires of Jubilee: Nat Turner's Fierce Rebellion"

    ERIC Educational Resources Information Center

    Briley, Ron

    2006-01-01

    This document is a study guide for Stephen B. Oates biography of Nat Turner, "The Fires of Jubilee." The book is a practical reading vehicle for introducing Nat Turner to secondary students in grades 11 and 12. Oates divides his work into four parts, which could provide the basis for four reading assignments, although the sections are…

  5. Genetic Variation at the N-acetyltransferase (NAT) Genes in Global Populations

    EPA Science Inventory

    Functional variability at the N-acetyltransferase (NAT) genes is associated with adverse drug reactions and cancer susceptibility in humans. Previous studies of small sets of ethnic groups have indicated that the NAT genes have high levels of amino acid variation that differ in f...

  6. Nucleic acid testing (NAT) in high prevalence-low resource settings.

    PubMed

    El Ekiaby, Magdy; Lelie, Nico; Allain, Jean-Pierre

    2010-01-01

    Blood screening by NAT for major transfusion transmitted viral infections (TTIs) was originally intended to complement serology for detection of infected donations. Reports from developed countries showed limited marginal value to NAT blood screening in improving blood safety. Reports on NAT results from Europe indicated yield of 1:0.6 million donations for HBV, <1:M for HCV and HIV-1-related to low prevalence of TTI. In contrast, prevalence of TTI in resource-limited countries is almost always high. As a result, more incident cases can be expected among first-time blood donors. Most reports of NAT blood donation screening in these countries showed NAT confirmed yield as high as 1/2800 for HBV and 1/3100 blood donations for HCV as reported from Thailand and Egypt, respectively. The issues for low resource countries are mostly the high cost of NAT but also the requirements of staff qualification, adequate facilities, reagent procurement and maintenance of delicate equipment. Alternatives to commercial NAT are the use of combos antigen-antibody for HIV and HCV, anti-HBc for HBV and in-house NAT. Most of these alternatives have been reported but very few comparisons are available. Once yield data is available, models for estimation of feasibility and cost-effectiveness are proposed to help decision-making.

  7. Antarctic NAT PSC Belt of June 2003: Observational Validation of the Mountain Wave Seeding Hypothesis

    NASA Technical Reports Server (NTRS)

    Eckermann, S. D.; Hoffmann, L.; Hoepfner, M.; Wu, D. L.; Alexander, M. J.

    2009-01-01

    Satellite observations of polar stratospheric clouds (PSCs) over Antarctica in June 2003 revealed small nitric acid trihydrate (NAT) particles forming suddenly along the vortex edge. Models suggest the trigger was mountain waves over the Antarctic Peninsula (AP) forming ice for NAT nucleation. We test this hypothesis by analyzing perturbations in stratospheric radiances from the Atmospheric Infrared Sounder (AIRS). AIRS data show mountain waves over the AP on 10-14 June, with no resolved wave activity before or after. Peak wave temperature amplitudes derived from independent 40 hPa channels all return values of 10-12 K, in agreement with values used to model this NAT event. These observations support a NAT wake from a small region of mountain wave activity over the AP as the source of this circumpolar NAT outbreak.

  8. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells

    PubMed Central

    Sugiyama, Hayami; Takahashi, Kazutoshi; Yamamoto, Takuya; Iwasaki, Mio; Narita, Megumi; Nakamura, Masahiro; Rand, Tim A.; Nakagawa, Masato; Watanabe, Akira; Yamanaka, Shinya

    2017-01-01

    Novel APOBEC1 target 1 (Nat1) (also known as “p97,” “Dap5,” and “Eif4g2”) is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (Eif4g1). We previously showed that Nat1-null mouse embryonic stem cells (mES cells) are resistant to differentiation. In the current study, we found that NAT1 and eIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors eIF3 and eIF4A and ribosomal proteins. However, NAT1 did not bind to eIF4E or poly(A)-binding proteins, which are critical for cap-dependent translation initiation. In contrast, compared with eIF4G1, NAT1 preferentially interacted with eIF2, fragile X mental retardation proteins (FMR), and related proteins and especially with members of the proline-rich and coiled-coil–containing protein 2 (PRRC2) family. We also found that Nat1-null mES cells possess a transcriptional profile similar, although not identical, to the ground state, which is established in wild-type mES cells when treated with inhibitors of the ERK and glycogen synthase kinase 3 (GSK3) signaling pathways. In Nat1-null mES cells, the ERK pathway is suppressed even without inhibitors. Ribosome profiling revealed that translation of mitogen-activated protein kinase kinase kinase 3 (Map3k3) and son of sevenless homolog 1 (Sos1) is suppressed in the absence of Nat1. Forced expression of Map3k3 induced differentiation of Nat1-null mES cells. These data collectively show that Nat1 is involved in the translation of proteins that are required for cell differentiation. PMID:28003464

  9. [Centenary of Victor Segalen's thesis].

    PubMed

    Mabin, Dominique

    2003-01-01

    Victor Segalen has attended his thesis of doctorate of medicine on January the 29th, 1902, L'Observation médicale chez les écrivans naturalists, known by the title Les Cliniciens ès-lettres. In this thesis we analyse the medical observation of the death of Jules de Goncourt, according to Goncourt's Journal.

  10. Daily Aa-nat gene expression in the camel (Camelus dromedarius) pineal gland.

    PubMed

    El Allali, Khalid; Sinitskaya, Natalia; Bothorel, Béatrice; Achaaban, Rachid; Pévet, Paul; Simonneaux, Valérie

    2008-09-01

    Arylalkylamine N-acetyltransferase (AA-NAT) is the rhythm-generating enzyme for the synthesis of pineal melatonin. Molecular investigations have revealed two biological models for the activation of AA-NAT. In rodent species, Aa-nat gene transcription is turned off during the daytime and markedly activated at night. In primates, sheep, and cows, the Aa-nat gene is constitutively transcripted with no visible daily variations. This inter-species difference in Aa-nat gene regulation leads to different daily profiles in melatonin synthesis and release. Thus, the nighttime onset of the rise in circulating melatonin is delayed and slow in rodents, whereas it is fast and sharp in sheep. In the camel (Camelus dromedarius), we have observed that circulating melatonin rises immediately after sunset, suggesting AA-NAT activity is regulated at the post-transcriptional level. In agreement with this hypothesis, we report herein the amount of Aa-nat mRNA in the camel pineal gland is high, during both the day and night with no daily variations, while melatonin concentration in the same pineal tissue is five times higher during the night than daytime.

  11. Heterogeneous formation of polar stratospheric clouds - Part 1: Nucleation of nitric acid trihydrate (NAT)

    NASA Astrophysics Data System (ADS)

    Hoyle, C. R.; Engel, I.; Luo, B. P.; Pitts, M. C.; Poole, L. R.; Grooß, J.-U.; Peter, T.

    2013-03-01

    Satellite based observations during the Arctic winter of 2009/2010 provide firm evidence that, in contrast to the current understanding, the nucleation of nitric acid trihydrate (NAT) in the polar stratosphere does not only occur on preexisting ice particles. In order to explain the NAT clouds observed over the Arctic in mid December 2009, a heterogeneous nucleation mechanism is required, occurring via immersion freezing on the surface of solid particles, likely of meteoritic origin. For the first time, a detailed microphysical modelling of this NAT formation pathway has been carried out. Heterogeneous NAT formation was calculated along more than sixty thousand trajectories, ending at Cloud Aerosol Lidar with Orthogonal Polarisation (CALIOP) observation points. Comparing the optical properties of the modelled NAT with these observations enabled the thorough validation of a newly developed NAT nucleation parameterisation, which has been built into the Zurich Optical and Microphysical box Model (ZOMM). The parameterisation is based on active site theory, is simple to implement in models and provides substantial advantages over previous approaches which involved a constant rate of NAT nucleation in a given volume of air. It is shown that the new method is capable of reproducing observed PSCs very well, despite the varied conditions experienced by air parcels travelling along the different trajectories. In a companion paper, ZOMM is applied to a later period of the winter, when ice PSCs are also present, and it is shown that the observed PSCs are also represented extremely well under these conditions.

  12. Heterogeneous formation of polar stratospheric clouds - Part 1: Nucleation of nitric acid trihydrate (NAT)

    NASA Astrophysics Data System (ADS)

    Hoyle, C. R.; Engel, I.; Luo, B. P.; Pitts, M. C.; Poole, L. R.; Grooß, J.-U.; Peter, T.

    2013-09-01

    Satellite-based observations during the Arctic winter of 2009/2010 provide firm evidence that, in contrast to the current understanding, the nucleation of nitric acid trihydrate (NAT) in the polar stratosphere does not only occur on preexisting ice particles. In order to explain the NAT clouds observed over the Arctic in mid-December 2009, a heterogeneous nucleation mechanism is required, occurring via immersion freezing on the surface of solid particles, likely of meteoritic origin. For the first time, a detailed microphysical modelling of this NAT formation pathway has been carried out. Heterogeneous NAT formation was calculated along more than sixty thousand trajectories, ending at Cloud Aerosol Lidar with Orthogonal Polarization (CALIOP) observation points. Comparing the optical properties of the modelled NAT with these observations enabled a thorough validation of a newly developed NAT nucleation parameterisation, which has been built into the Zurich Optical and Microphysical box Model (ZOMM). The parameterisation is based on active site theory, is simple to implement in models and provides substantial advantages over previous approaches which involved a constant rate of NAT nucleation in a given volume of air. It is shown that the new method is capable of reproducing observed polar stratospheric clouds (PSCs) very well, despite the varied conditions experienced by air parcels travelling along the different trajectories. In a companion paper, ZOMM is applied to a later period of the winter, when ice PSCs are also present, and it is shown that the observed PSCs are also represented extremely well under these conditions.

  13. Heterogeneous Formation of Polar Stratospheric Clouds- Part 1: Nucleation of Nitric Acid Trihydrate (NAT)

    NASA Technical Reports Server (NTRS)

    Hoyle, C. R.; Engel, I.; Luo, B. P.; Pitts, M. C.; Poole, L. R.; Grooss, J.-U.; Peter, T.

    2013-01-01

    Satellite-based observations during the Arctic winter of 2009/2010 provide firm evidence that, in contrast to the current understanding, the nucleation of nitric acid trihydrate (NAT) in the polar stratosphere does not only occur on preexisting ice particles. In order to explain the NAT clouds observed over the Arctic in mid-December 2009, a heterogeneous nucleation mechanism is required, occurring via immersion freezing on the surface of solid particles, likely of meteoritic origin. For the first time, a detailed microphysical modelling of this NAT formation pathway has been carried out. Heterogeneous NAT formation was calculated along more than sixty thousand trajectories, ending at Cloud Aerosol Lidar with Orthogonal Polarization (CALIOP) observation points. Comparing the optical properties of the modelled NAT with these observations enabled a thorough validation of a newly developed NAT nucleation parameterisation, which has been built into the Zurich Optical and Microphysical box Model (ZOMM). The parameterisation is based on active site theory, is simple to implement in models and provides substantial advantages over previous approaches which involved a constant rate of NAT nucleation in a given volume of air. It is shown that the new method is capable of reproducing observed polar stratospheric clouds (PSCs) very well, despite the varied conditions experienced by air parcels travelling along the different trajectories. In a companion paper, ZOMM is applied to a later period of the winter, when ice PSCs are also present, and it is shown that the observed PSCs are also represented extremely well under these conditions.

  14. 14 CFR Appendix C to Part 91 - Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace C Appendix C to Part 91 Aeronautics and... North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace Section 1 NAT...

  15. 14 CFR Appendix C to Part 91 - Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace C Appendix C to Part 91 Aeronautics and... North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace Section 1 NAT...

  16. 14 CFR Appendix C to Part 91 - Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace C Appendix C to Part 91 Aeronautics and... North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace Section 1 NAT...

  17. 14 CFR Appendix C to Part 91 - Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace C Appendix C to Part 91 Aeronautics and... North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace Section 1 NAT...

  18. 75 FR 22814 - Guidance for Industry: Nucleic Acid Testing (NAT) for Human Immunodeficiency Virus Type 1 (HIV-1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ...: Nucleic Acid Testing (NAT) for Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis C Virus (HCV... Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis C Virus (HCV): Testing, Product Disposition, and Donor Deferral... Immunodeficiency Virus Type 1 (HIV-1) Nucleic Acid Test (NAT) and Hepatitis C Virus (HCV) NAT, on...

  19. Heterogeneous kinetics of H2O, HNO3 and HCl on HNO3 hydrates (α-NAT, β-NAT, NAD) in the range 175-200 K

    NASA Astrophysics Data System (ADS)

    Iannarelli, Riccardo; Rossi, Michel J.

    2016-09-01

    Experiments on the title compounds have been performed using a multidiagnostic stirred-flow reactor (SFR) in which the gas phase as well as the condensed phase has been simultaneously investigated under stratospheric temperatures in the range 175-200 K. Wall interactions of the title compounds have been taken into account using Langmuir adsorption isotherms in order to close the mass balance between deposited and desorbed (recovered) compounds. Thin solid films at 1 µm typical thickness have been used as a proxy for atmospheric ice particles and have been deposited on a Si window of the cryostat, with the optical element being the only cold point in the deposition chamber. Fourier transform infrared (FTIR) absorption spectroscopy in transmission as well as partial and total pressure measurement using residual gas mass spectrometry (MS) and sensitive pressure gauges have been employed in order to monitor growth and evaporation processes as a function of temperature using both pulsed and continuous gas admission and monitoring under SFR conditions. Thin solid H2O ice films were used as the starting point throughout, with the initial spontaneous formation of α-NAT (nitric acid trihydrate) followed by the gradual transformation of α- to β-NAT at T > 185 K. Nitric acid dihydrate (NAD) was spontaneously formed at somewhat larger partial pressures of HNO3 deposited on pure H2O ice. In contrast to published reports, the formation of α-NAT proceeded without prior formation of an amorphous HNO3 / H2O layer and always resulted in β-NAT. For α- and β-NAT, the temperature-dependent accommodation coefficient α(H2O) and α(HNO3), the evaporation flux Jev(H2O) and Jev(HNO3) and the resulting saturation vapor pressure Peq(H2O) and Peq(HNO3) were measured and compared to binary phase diagrams of HNO3 / H2O in order to afford a thermochemical check of the kinetic parameters. The resulting kinetic and thermodynamic parameters of activation energies for evaporation (Eev) and

  20. Expression of NAT2 in immune system cells and the relation of NAT2 gene polymorphisms in the anti-tuberculosis therapy in Mexican mestizo population.

    PubMed

    Salazar-González, R; Gómez, R; Romano-Moreno, S; Medellín-Garibay, S; Núñez-Ruíz, A; Magaña-Aquino, M; Milán-Segovia, R C; Portales-Pérez, D P

    2014-12-01

    Arylamine N-acetyltransferase 2 (NAT2) metabolizes isoniazid (INH) and Single Nucleotide Polymorphisms (SNP) responsible for its activity has been reported. The aim of this study in the Mexican mestizo population was to evaluate NAT2 expression at the protein level in immune cells, as well as the distribution and frequency of six NAT2 SNPs and their association with anti-TB therapy, by measuring the plasma levels of INH and Acetyl-INH (AcINH). We performed genotyping assays of NAT2 SNPs in 40 TB patients and 121 healthy volunteers by real-time PCR. A method for detecting NAT2 in immune cells using flow cytometry was developed. Plasma concentrations of INH and AcINH were obtained by HPLC in TB patients and the Metabolic Ratio (MR) was calculated. The phenotypes obtained in the healthy volunteers were as follows; 18.87 % of subjects had the rapid acetylator phenotype, 45.45 % had the intermediate phenotype and 39.66 % exhibited the slow acetylator phenotype. In the TB patient group, 35 % of patients had the rapid acetylator phenotype, 32.5 % were intermediate and 32.5 % showed the slow acetylator phenotype. A higher expression level of NAT2 in innate immune cells from TB patients compared to those from healthy volunteers was detected (P < 0.013). In TB patients the MR showed a bimodal distribution with an antimode of 0.7, which was used as a threshold value for acetylator classification. A high correspondence between the rapid and slow acetylator phenotype with MR was demonstrated. In conclusion, the 282C>T, 341T>C, 481C>T, 590G>A, 803A>G, 857G>A SNPs of NAT2 gene provides accurate for prediction of the acetylator phenotype in Mexican mestizo population. A statistical difference was found in frequency of rapid metabolizer phenotype, which was higher in TB patients. In addition, the expression of NAT2 protein in immune cells can lead to further studies related to its functional role in the innate immune response against M. tuberculosis and other xenobiotics

  1. NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region

    PubMed Central

    Arias, Isis; Lecompte, Nelly; Visbal, Lila; Curiel, Iliana; Hernández, Enio; Garavito, Pilar

    2014-01-01

    Objective: To study the NAT2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations. Methods: A total of 202 subjects were studied: 47 Chimila, 55 Wiwa, and 100 Wayuu. The polymorphisms were identified using a real-time PCR method for allelic discrimination designed using Taqman of Applied Biosystems. Results: The following alleles were found at the highest frequency in the following groups: the NAT2*4 allele (wild type) in the Wayuu group (55.3%), the NAT2*5 allele in the Wiwa group (34.5%), and the NAT2*7 allele in the Chimila group (24.2%). A higher frequency of the rapid acetylator status was found in the Wayuu group (31.3%) and Chimila group (29.5%) compared with the Wiwa group (12.7%). The intermediate acetylator status distribution was very similar in all three groups, and the frequency of the slow acetylator status was higher in the Wiwa group (32.7%) compared with the Chimila and Wayuu groups (20.5% and 21.2%, respectively). Conclusion: The results demonstrated the allelic distribution and pharmacogenetic differences of the three groups studied and revealed the most frequent acetylator status and phenotype. Because of the high prevalence of slow acetylators, a greater incidence of tuberculosis (TB) drug-induced hepatotoxicity is predicted in these populations, with a higher frequency in the Wiwa group. PMID:25767302

  2. Denitrification by large NAT particles: the impact of reduced settling velocities and hints on particle characteristics

    NASA Astrophysics Data System (ADS)

    Woiwode, W.; Grooß, J.-U.; Oelhaf, H.; Molleker, S.; Borrmann, S.; Ebersoldt, A.; Frey, W.; Gulde, T.; Khaykin, S.; Maucher, G.; Piesch, C.; Orphal, J.

    2014-03-01

    Vertical redistribution of HNO3 through condensation, sedimentation and evaporation of large HNO3-containing particles inside polar stratospheric clouds (PSCs) plays an important role in the chemistry of the Arctic winter stratosphere. In situ observations by the particle probe FSSP-100 during the RECONCILE campaign indicate unexpected large potential NAT (nitric acid trihydrate) particles inside PSCs. The observations can hardly be explained assuming particles with compact morphology and spherical shape due to limited growing time at temperatures below the existence temperature of NAT (TNAT). Utilizing simulations by the CLaMS and measurements by the airborne Fourier transform infrared spectrometer MIPAS-STR we study the impact of reduced settling velocities of NAT particles on vertical HNO3 redistribution. Reduced settling velocities are expected for spherical NAT particles with low mass density or aspheric NAT particles that might explain the maximum sizes of the particles observed in situ. The results of our study support the hypothesis that denitrification is produced by significantly aspheric (i.e. columnar) compact NAT particles which are characterised by reduced settling velocities.

  3. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation.

    PubMed

    Liu, Haijing; Ling, Yun; Gong, Yilei; Sun, Ying; Hou, Lin; Zhang, Bo

    2007-06-01

    NAT10 (N-acetyltransferase 10) is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity. The presented research shows its transcriptional activation by genotoxic agents and possible role in DNA damage. NAT10 mRNA could be markedly increased by using hydrogen peroxide (H2O2) or cisplatin in a dose- and time-dependent way, and the immunofluorescent staining revealed that the treatment of H2O2 or cisplatin induced focal accumulation of NAT10 protein in cellular nuclei. Both H2O2 and cisplatin could stimulate the transcriptional activity of the NAT10 promoter through the upstream sequences from -615 bp to +110 bp, with which some nuclear proteins interacted. Ectopic expression of NAT10 could enhance the number of survival cells in the presence of H2O2 or cisplatin. The above results suggested that NAT10 could be involved in DNA damage response and increased cellular resistance to genotoxicity.

  4. Molecular Basis of Substrate Specific Acetylation by N-Terminal Acetyltransferase NatB.

    PubMed

    Hong, Haiyan; Cai, Yongfei; Zhang, Shijun; Ding, Hongyan; Wang, Haitao; Han, Aidong

    2017-04-04

    The NatB N-terminal acetyltransferase specifically acetylates the N-terminal group of substrate protein peptides starting with Met-Asp/Glu/Asn/Gln. How NatB recognizes and acetylates these substrates remains unknown. Here, we report crystal structures of a NatB holoenzyme from Candida albicans in the presence of its co-factor CoA and substrate peptides. The auxiliary subunit Naa25 of NatB forms a horseshoe-like deck to hold specifically its catalytic subunit Naa20. The first two amino acids Met and Asp of a substrate peptide mediate the major interactions with the active site in the Naa20 subunit. The hydrogen bonds between the substrate Asp and pocket residues of Naa20 are essential to determine the NatB substrate specificity. Moreover, a hydrogen bond between the amino group of the substrate Met and a carbonyl group in the Naa20 active site directly anchors the substrate toward acetyl-CoA. Together, these structures define a unique molecular mechanism of specific N-terminal acetylation acted by NatB.

  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB

    PubMed Central

    Van Damme, Petra; Lasa, Marta; Polevoda, Bogdan; Gazquez, Cristina; Elosegui-Artola, Alberto; Kim, Duk Soo; De Juan-Pardo, Elena; Demeyer, Kimberly; Hole, Kristine; Larrea, Esther; Timmerman, Evy; Prieto, Jesus; Arnesen, Thomas; Sherman, Fred; Gevaert, Kris; Aldabe, Rafael

    2012-01-01

    Protein N-terminal acetylation (Nt-acetylation) is an important mediator of protein function, stability, sorting, and localization. Although the responsible enzymes are thought to be fairly well characterized, the lack of identified in vivo substrates, the occurrence of Nt-acetylation substrates displaying yet uncharacterized N-terminal acetyltransferase (NAT) specificities, and emerging evidence of posttranslational Nt-acetylation, necessitate the use of genetic models and quantitative proteomics. NatB, which targets Met-Glu-, Met-Asp-, and Met-Asn-starting protein N termini, is presumed to Nt-acetylate 15% of all yeast and 18% of all human proteins. We here report on the evolutionary traits of NatB from yeast to human and demonstrate that ectopically expressed hNatB in a yNatB-Δ yeast strain partially complements the natB-Δ phenotypes and partially restores the yNatB Nt-acetylome. Overall, combining quantitative N-terminomics with yeast studies and knockdown of hNatB in human cell lines, led to the unambiguous identification of 180 human and 110 yeast NatB substrates. Interestingly, these substrates included Met-Gln- N-termini, which are thus now classified as in vivo NatB substrates. We also demonstrate the requirement of hNatB activity for maintaining the structure and function of actomyosin fibers and for proper cellular migration. In addition, expression of tropomyosin-1 restored the altered focal adhesions and cellular migration defects observed in hNatB-depleted HeLa cells, indicative for the conserved link between NatB, tropomyosin, and actin cable function from yeast to human. PMID:22814378

  6. NAT1 polymorphisms and cancer risk: a systematic review and meta-analysis

    PubMed Central

    Zhang, Kunyi; Gao, Lijuan; Wu, Yuqi; Chen, Jianyi; Lin, Chengguang; Liang, Shaohua; Su, Jianxin; Ye, Jinming; He, Xuyu

    2015-01-01

    Purpose: To investigate the association between the N-acetyltransferase 1 (NAT1) slow and rapid acetylation phenotypes with cancer risk based on a meta-analysis. Methods: Previously published case-control studies were retrieved from PubMed, Embase, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined to assess the relationship between NAT1 polymorphisms and cancer risk. Results: A total of 73 studies (24874 cases and 30226 controls) were included in this meta-analysis. No significant association was identified between NAT1 polymorphisms (slow acetylation versus rapid acetylation genotypes: OR = 0.978, 95% CI = 0.927-1.030, P < 0.001 for heterogeneity, I2 = 45.5%) and cancer risk, whereas a significantly reduced risk of pancreatic cancer was identified in individuals with NAT1 slow acetylation genotype (OR = 0.856, 95% CI = 0.733-0.999, P =0.509 for heterogeneity, I2 = 0). When the NAT1 slow acetylation genotype was analysed on the basis of stratified analyses of ethnicity, a significantly reduced risk of head and neck cancers was found among Asian (OR=0.281, 95% CI = 0.127-0.622). When the NAT1 slow acetylation genotype was analysed on the basis of stratified analyses of source of control, only significantly reduced risks of colorectal cancer (OR = 0.882, 95% CI = 0.798- 0.974, P = 0.212 for heterogeneity, I2 = 22.9) and pancreatic cancer (OR=0.856, 95% CI = 0.733-0.999, P = 0.509 for heterogeneity, I2 = 0) were found among hospital-based studies. Conclusions: No significant association between the NAT1 polymorphisms and the risk of cancer was found except for pancreatic cancer. PMID:26309576

  7. How to write a thesis.

    PubMed

    Cunningham, S J

    2004-06-01

    The prospect of writing a thesis can be intimidating. However, there are certain formats that the writer should follow in order to make life much easier. This article covers a logical approach to presenting research findings. Also included are suggestions for a last minute checklist.

  8. iThesis: Polly's project

    ERIC Educational Resources Information Center

    Conti, Alvaro

    2013-01-01

    This paper outlines an attempt to loosen the existing role and structure of the traditional "thesis" as the key undergraduate learning instrument within universities in Thailand. It does so by describing an exemplary project -- Polly's project - that uses technology to facilitate an exit from the "regulatory space" in which…

  9. Spatial vision anomalies in Renaissance art: Raphael, Giorgione, Dürer.

    PubMed

    Weale, Robert

    2008-01-01

    Two-dimensional views of three-dimensional space are based on conventions. Renaissance perspectival drawing invented by Brunelleschi is one of them. It caused difficulties to fifteenth and sixteenth century and later artists, although readily taken up by those understanding mathematics. Raphael was amongst those who did not seem to have understood some of its elements: this is illustrated in the first section. The second addresses the question of whether a squint may manifest in an artist's work. Giorgione's ocular anomaly was well documented by several of his self-portraits, and reference is made to some of his paintings with a special analysis of The Tempest. The final section deals with chromatic stereoscopy, with particular reference to the work of Dürer. His apparently anomalous spatial sense is tentatively explained with the suggestion that he may have suffered from a defect of colour vision (protanomaly).

  10. [The celestial phenomena in A. Dürer's engraving Melancholia I].

    PubMed

    Weitzel, Hans

    2009-01-01

    The celestial body of Dürer's engraving Melencolia I is connected with his painting of a meteor, the Raveningham-painting; it is shown that the origin of this painting owns to the impact of the meteor of Ensisheim in 1492. Until now the celestial body, the balance, and the magic square are nearly consistently interpreted as the planet Saturn, the zodiac sign Libra, and the planet Jupiter, and the melancholy woman is subject to these heavenly bodies. Consequently, neoplatonic astrology has been the main focus of the engraving; including the rainbow, the engraving has also been interpreted biblically. The present paper, however, places emphasis on problems of the geometry as the reason of melancholy. Any astronomical meaning of the configuration of the numbers of the magic square is discarded.

  11. Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels

    PubMed Central

    Jurisch-Yaksi, Nathalie; Rose, Applonia J.; Lu, Huiqi; Raemaekers, Tim; Munck, Sebastian; Baatsen, Pieter; Baert, Veerle; Vermeire, Wendy; Scales, Suzie J.; Verleyen, Daphne; Vandepoel, Roel; Tylzanowski, Przemko; Yaksi, Emre; de Ravel, Thomy; Yost, H. Joseph; Froyen, Guy; Arrington, Cammon B.

    2013-01-01

    Cilia project from the surface of most vertebrate cells and are important for several physiological and developmental processes. Ciliary defects are linked to a variety of human diseases, named ciliopathies, underscoring the importance of understanding signaling pathways involved in cilia formation and maintenance. In this paper, we identified Rer1p as the first endoplasmic reticulum/cis-Golgi–localized membrane protein involved in ciliogenesis. Rer1p, a protein quality control receptor, was highly expressed in zebrafish ciliated organs and regulated ciliary structure and function. Both in zebrafish and mammalian cells, loss of Rer1p resulted in the shortening of cilium and impairment of its motile or sensory function, which was reflected by hearing, vision, and left–right asymmetry defects as well as decreased Hedgehog signaling. We further demonstrate that Rer1p depletion reduced ciliary length and function by increasing γ-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression. PMID:23479743

  12. 78 FR 4585 - Culturally Significant Objects Imported for Exhibition Determinations: “Albrecht Dürer: Master...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Albrecht D rer: Master Drawings... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Albrecht D...

  13. Red meat intake, NAT2, and risk of colorectal cancer: A pooled analysis of 11 studies

    PubMed Central

    Ananthakrishnan, Ashwin N.; Du, Mengmeng; Berndt, Sonja I.; Brenner, Hermann; Caan, Bette J.; Casey, Graham; Chang-Claude, Jenny; Duggan, David; Fuchs, Charles S.; Gallinger, Steven; Giovannucci, Edward L.; Harrison, Tabitha A.; Hayes, Richard B.; Hoffmeister, Michael; Hopper, John L.; Hou, Lifang; Hsu, Li; Jenkins, Mark A.; Kraft, Peter; Ma, Jing; Nan, Hongmei; Newcomb, Polly A.; Ogino, Shuji; Potter, John D.; Seminara, Daniela; Slattery, Martha L.; Thornquist, Mark; White, Emily; Wu, Kana; Peters, Ulrike; Chan, Andrew T.

    2014-01-01

    Background Red meat intake has been associated with risk of colorectal cancer (CRC), potentially mediated through heterocyclic amines. The metabolic efficiency of N-acetyltransferase 2 (NAT2) required for the metabolic activation of such amines is influenced by genetic variation. The interaction between red meat intake, NAT2 genotype, and CRC has been inconsistently reported. Methods We used pooled individual-level data from the Colon Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Red meat intake was collected by each study. We inferred NAT2 phenotype based on polymorphism at rs1495741, highly predictive of enzyme activity. Interaction was assessed using multiplicative interaction terms in multivariate-adjusted models. Results From 11 studies, 8,290 CRC cases and 9,115 controls were included. The highest quartile of red meat intake was associated with increased risk of CRC compared to the lowest quartile (OR 1.41, 95%CI 1.29 – 1.55). However, a significant association was observed only for studies with retrospective diet data, not for studies with diet prospectively assessed before cancer diagnosis. Combining all studies, high red meat intake was similarly associated with CRC in those with a rapid/intermediate NAT2 genotype (OR 1.38, 95%CI 1.20 – 1.59) as with a slow genotype (OR 1.43, 95%CI 1.28 – 1.61) (p- interaction=0.9). Conclusion We found that high red meat intake was associated with increased risk of CRC only from retrospective case-control studies and not modified by NAT2 enzyme activity. Impact Our results suggest no interaction between NAT2 genotype and red-meat intake in mediating risk of CRC. PMID:25342387

  14. Denitrification by large NAT particles: the impact of reduced settling velocities and hints on particle characteristics

    NASA Astrophysics Data System (ADS)

    Woiwode, W.; Grooß, J.-U.; Oelhaf, H.; Molleker, S.; Borrmann, S.; Ebersoldt, A.; Frey, W.; Gulde, T.; Khaykin, S.; Maucher, G.; Piesch, C.; Orphal, J.

    2014-10-01

    Vertical redistribution of HNO3 through large HNO3-containing particles associated with polar stratospheric clouds (PSCs) plays an important role in the chemistry of the Arctic winter stratosphere. During the RECONCILE (Reconciliation of essential process parameters for an enhanced predictability of Arctic stratospheric ozone loss and its climate interactions) campaign, apparently very large NAT (nitric acid trihydrate) particles were observed by the airborne in situ probe FSSP-100 (Molleker et al., 2014). Our analysis shows that the FSSP-100 observations associated with the flight on 25 January 2010 cannot easily be explained assuming compact spherical NAT particles due to much too short growing time at temperatures below the existence temperature of NAT (TNAT). State-of-the-art simulations using CLaMS (Chemical Lagrangian Model of the Stratosphere; Grooß et al., 2014) suggest considerably smaller particles. We consider the hypothesis that the simulation reproduces the NAT particle masses in a realistic way, but that real NAT particles may have larger apparent sizes compared to compact spherical particles, e.g. due to non-compact morphology or aspheric shape. Our study focuses on the consequence that such particles would have reduced settling velocities compared to compact spheres, altering the vertical redistribution of HNO3. Utilising CLaMS simulations, we investigate the impact of reduced settling velocities of NAT particles on vertical HNO3 redistribution and compare the results with observations of gas-phase HNO3 by the airborne Fourier transform spectrometer MIPAS-STR associated with two RECONCILE flights. The MIPAS-STR observations confirm conditions consistent with denitrification by NAT particles for the flight on 25 January 2010 and show good agreement with the simulations within the limitations of the comparison. Best agreement is found if settling velocities between 100 and 50% relative to compact spherical particles are considered (slight preference

  15. Publication of a thesis: the relationship between graduate student and thesis advisor.

    PubMed

    Giefer, C

    1996-01-01

    Identifying the roles the graduate student and the thesis advisor will undertake when preparing the thesis helps when the thesis is published. Such issues as bylines and copyrights should be agreed upon before embarking on the thesis work. The author, an Associate Professor in the nursing department at a state university, clarifies the roles of the graduate student and thesis advisor.

  16. Transcription factors may frame Aa-nat gene expression and melatonin synthesis at night in the Syrian hamster pineal gland.

    PubMed

    Garidou, Marie-Laure; Diaz, Elena; Calgari, Christiane; Pévet, Paul; Simonneaux, Valérie

    2003-06-01

    Pineal melatonin synthesis is stimulated at night following an increase in arylalkylamine-N-acetyltransferase (AA-NAT) activity. Depending on the species, two mechanisms of enzyme activation have been described: a cAMP/phospho-cAMP response element-binding protein-dependent stimulation of Aa-nat gene transcription in the rat, presumed to occur in all rodents, or a posttranslational regulation of AA-NAT protein in ongulates. The present data obtained in the Syrian hamster indicate another route of AA-NAT regulation. Elevated nocturnal levels of Aa-nat mRNA were strongly suppressed following light exposure or adrenergic antagonist administration, demonstrating the involvement of norepinephrine in the stimulation of melatonin synthesis. However, administration of adrenergic agonists during the day did not increase Aa-nat mRNA unless a protein synthesis inhibitor was given during the previous night. This indicates that an inhibitory protein, synthesized at night, prevents melatonin synthesis during the day. By contrast, a protein synthesis inhibitor given at the beginning of the night markedly reduced Aa-nat mRNA, suggesting that a stimulatory protein (transcription factor?) is necessary for Aa-nat gene transcription at night. Noteworthy, hamsters raised in long photoperiod were responsive to adrenergic agonist injection only in the first hour after light onset, a response that may be important in this photoperiodic species in which the melatonin peak extends into the morning hours in a short photoperiod.

  17. Proper regulation of a sperm-specific cis-nat-siRNA is essential for double fertilization in Arabidopsis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    /Cis/-nat-siRNAs are a recently characterized class of small regulatory RNAs that are widespread in eukaryotes. Despite their abundance the importance of their regulatory activity is largely unknown. The only functional role for eukaryotic /cis/-nat-siRNAs that has been described to date is in envir...

  18. AmeriFlux US-SP1 Slashpine-Austin Cary- 65yrs nat regen

    DOE Data Explorer

    Martin, Tim [University of Florida

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-SP1 Slashpine-Austin Cary- 65yrs nat regen. Site Description - The ACMF site is a 67 hectare naturally regenerated Pinus palustris and Pinus elliottii mixed stand.

  19. National Carbon Sequestration Database and Geographic Information System (NatCarb)

    SciTech Connect

    Kenneth Nelson; Timothy Carr

    2009-03-31

    This annual and final report describes the results of the multi-year project entitled 'NATional CARBon Sequestration Database and Geographic Information System (NatCarb)' (http://www.natcarb.org). The original project assembled a consortium of five states (Indiana, Illinois, Kansas, Kentucky and Ohio) in the midcontinent of the United States (MIDCARB) to construct an online distributed Relational Database Management System (RDBMS) and Geographic Information System (GIS) covering aspects of carbon dioxide (CO{sub 2}) geologic sequestration. The NatCarb system built on the technology developed in the initial MIDCARB effort. The NatCarb project linked the GIS information of the Regional Carbon Sequestration Partnerships (RCSPs) into a coordinated regional database system consisting of datasets useful to industry, regulators and the public. The project includes access to national databases and GIS layers maintained by the NatCarb group (e.g., brine geochemistry) and publicly accessible servers (e.g., USGS, and Geography Network) into a single system where data are maintained and enhanced at the local level, but are accessed and assembled through a single Web portal to facilitate query, assembly, analysis and display. This project improves the flow of data across servers and increases the amount and quality of available digital data. The purpose of NatCarb is to provide a national view of the carbon capture and storage potential in the U.S. and Canada. The digital spatial database allows users to estimate the amount of CO{sub 2} emitted by sources (such as power plants, refineries and other fossil-fuel-consuming industries) in relation to geologic formations that can provide safe, secure storage sites over long periods of time. The NatCarb project worked to provide all stakeholders with improved online tools for the display and analysis of CO{sub 2} carbon capture and storage data through a single website portal (http://www.natcarb.org/). While the external project is

  20. Knockdown of a nutrient amino acid transporter gene LdNAT1 reduces free neutral amino acid contents and impairs Leptinotarsa decemlineata pupation

    PubMed Central

    Fu, Kai-Yun; Guo, Wen-Chao; Ahmat, Tursun; Li, Guo-Qing

    2015-01-01

    A Leptinotarsa decemlineata SLC6 NAT gene (LdNAT1) was cloned. LdNAT1 was highly expressed in the larval alimentary canal especially midgut. LdNAT1 mRNA levels were high right after the molt and low just before the molt. JH and a JH analog pyriproxyfen activated LdNAT1 expression. RNAi of an allatostatin gene LdAS-C increased JH and upregulated LdNAT1 transcription. Conversely, silencing of a JH biosynthesis gene LdJHAMT decreased JH and reduced LdNAT1 expression. Moreover, 20E and an ecdysteroid agonist halofenozide repressed LdNAT1 expression, whereas a decrease in 20E by RNAi of an ecdysteroidogenesis gene LdSHD and disruption of 20E signaling by knockdown of LdE75 and LdFTZ-F1 activated LdNAT1 expression. Thus, LdNAT1 responded to both 20E and JH. Moreover, knockdown of LdNAT1 reduced the contents of cysteine, histidine, isoleucine, leucine, methionine, phenylalanine and serine in the larval bodies and increased the contents of these amino acids in the larval feces. Furthermore, RNAi of LdNAT1 inhibited insulin/target of rapamycin pathway, lowered 20E and JH titers, reduced 20E and JH signaling, retarded larval growth and impaired pupation. These data showed that LdNAT1 was involved in the absorption of several neutral amino acids critical for larval growth and metamorphosis. PMID:26657797

  1. Do NAD and NAT form in liquid stratospheric aerosols by pseudoheterogeneous nucleation?

    PubMed

    Knopf, Daniel A

    2006-05-04

    Laboratory data of the freezing of nitric acid hydrates (NAD, NAT) from HNO(3)/H(2)O and HNO(3)/H(2)SO(4)/H(2)O solution droplets have been evaluated with respect to a "pseudoheterogeneous" (surface-induced) nucleation mechanism of NAD and NAT, which has been argued to possibly lead to the formation of polar stratospheric clouds (PSCs). In addition, a parametrization of pseudoheterogeneous nucleation of NAD and NAT suggested recently (Tabazadeh et al. J. Phys. Chem. A 2002, 106, 10238-10246) has been analyzed, showing that this parametrization should not be used in stratospheric modeling studies. The analysis of several laboratory data sets yields an upper limit of the pseudoheterogeneous nucleation rate coefficient of NAD of 2.2 x 10(-5) cm(-2) s(-1). In contrast, the upper limit of the pseudoheterogeneous nucleation rate coefficient of NAT could not be constrained satisfactorily, since formation of NAT has not been observed at stratospheric conditions in laboratory experiments applying small droplets. Maximum NAD production rates of 9.6 x 10(-9) cm(-3) (air) h(-1) in the stratosphere have been estimated assuming a pseudoheterogeneous nucleation mechanism that is constrained by the experimental observations. If maximum NAD supersaturation persisted for 4 weeks in the polar stratosphere the corresponding NAD particle number densities are estimated to be about 6 x 10(-6) cm(-3). These particle number densities are 3 orders of magnitude lower than particle number densities recently observed in the stratosphere. In conclusion, on the basis of laboratory data it is found that a pseudoheterogeneous nucleation mechanism is not sufficient to explain recent observations of large nitric acid containing particles in the polar stratosphere.

  2. An Experiment in Thesis: A Universal Approach

    ERIC Educational Resources Information Center

    Noteboom, Jay

    1975-01-01

    This experimental lesson gives students practice at writing a one sentence thesis statement. Each student chooses a song or short poem for which he must provide a thesis statement. The exercise not only teaches development of the thesis statement, but also stimulates student interest and discussion. Examples are presented. (AH)

  3. [Polyhedron of Dürer's engraving Melancholia. I--a Nürnberg sketch representing the Archimedean body].

    PubMed

    Weitzel, Hans

    2007-01-01

    New mathematical hypotheses are postulated concerning the truncated rhombohedron in Dürer's engraving Melencolia.I as well as the relation of the rhombohedron to the magic square. The two free parameters of a truncated rhombohedron have to be chosen in a way that (i) its front orthogonal elevation is nearly quadratical and with the form of the magic square, and that (ii) it possesses approximately a circumscribed sphere. Both conditions result in a value of 79.2 degrees for the angle of the rhombohedron. Measuring two lengths of the rhombohedron of the engraving yields the same value. In the magic square, the numbers are positioned in a way that the connection lines between four numbers give the sum 34 for lines which are the projection lines of the edges of the rhombohedron. In the Nürnberg-Codex of Dürer's manuscripts, exists a page with some sketches of mostly archimedean solids. One sketch represents a pentagon with approximately the measures of the six lateral faces of the truncated rhombohedron. It has to be looked upon as a preliminary sketch for the solid of the engraving. In 1543 Augustin Hirschvogel from Nürnberg, as the next after Dürer, rediscovered a further archimedean solid; this rediscovering has been attributed to D. Barbaro until now.

  4. Choosing to write the paper format thesis.

    PubMed

    Morris, H M; Tipples, G

    1998-04-01

    Graduate students today may be faced with the option of writing either a traditional format thesis or a paper format thesis. In contrast to the traditional format in which the text body consists of four or five chapters, the body of the paper format thesis can be comprised of an introductory chapter, two or more papers written as publishable manuscripts, and a conclusion. In this article, an overview of the paper format thesis is presented and contrasted with the traditional format thesis. The description of the paper format thesis is followed by its advantages and disadvantages for writers and readers. It is by weighing all possible pros and cons, as well as considering one's individual situation, that the graduate student will be able to decide which format of thesis to write.

  5. Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion.

    PubMed

    Rong, Ziye; Ouyang, Zhuqing; Magin, Robert S; Marmorstein, Ronen; Yu, Hongtao

    2016-09-02

    During the cell cycle, sister-chromatid cohesion tethers sister chromatids together from S phase to the metaphase-anaphase transition and ensures accurate segregation of chromatids into daughter cells. N-terminal acetylation is one of the most prevalent protein covalent modifications in eukaryotes and is mediated by a family of N-terminal acetyltransferases (NAT). Naa50 (also called San) has previously been shown to play a role in sister-chromatid cohesion in metazoans. The mechanism by which Naa50 contributes to cohesion is not understood however. Here, we show that depletion of Naa50 in HeLa cells weakens the interaction between cohesin and its positive regulator sororin and causes cohesion defects in S phase, consistent with a role of Naa50 in cohesion establishment. Strikingly, co-depletion of NatA, a heterodimeric NAT complex that physically interacts with Naa50, rescues the sister-chromatid cohesion defects and the resulting mitotic arrest caused by Naa50 depletion, indicating that NatA and Naa50 play antagonistic roles in cohesion. Purified recombinant NatA and Naa50 do not affect each other's NAT activity in vitro Because NatA and Naa50 exhibit distinct substrate specificity, we propose that they modify different effectors and regulate sister-chromatid cohesion in opposing ways.

  6. Calibration factors for determination of relativistic particle induced fission rates in natU, 235U, 232Th, natPb and 197Au foils

    NASA Astrophysics Data System (ADS)

    Hashemi-Nezhad, S. R.; Zhuk, Igor; Potapenko, A.; Kievets, M.; Krivopustov, M. I.

    2012-02-01

    Calibration factors w, for determination of fission rate in metallic foils of natU, 235U, 232Th, natPb and 197Au were determined for foils in contact with synthetic mica track detectors. Proton-induced fission at proton energies of 0.7 GeV and 1.5 GeV were used. Using our experimental results as well as those of the other authors, w for different foil-mica systems were determined. Two methods were used to calculate w, relative to the calibration factor for uranium-mica system, which has been obtained in a standard neutron field of energy 14.7 MeV. One of these methods requires the knowledge of the mean range of the fission fragments in the foils of interest and other method needs information on the values of the fission cross-sections at the required energies as well as the density of the tracks recorded in the track detectors in contact with the foil surfaces. The obtained w-values were compared with Monte Carlo calculations and good agreements were found. It is shown that a calibration factor obtained at low energy neutron induced fissions in uranium isotopes deviates only by less than 10% from those obtained at relativistic proton induced fissions.

  7. Automated Triplex (HBV, HCV and HIV) NAT Assay Systems for Blood Screening in India

    PubMed Central

    2016-01-01

    This review is confined to triplex nucleic acid testing (NAT) assays to be used on fully automated platform. Around the world, these assays are being used at various transfusion medicine centres or blood banks to screen blood units for HBV, HCV and HIV. These assay systems can screen up to 1000 blood units for HBV, HCV and HIV simultaneously in a day. This area has been dominated by mainly two manufacturers: M/s Gen-Probe-Novartis and M/s Roche Molecular Systems. The triplex NAT assay systems of both manufacturers are licensed by United States Food and Drug Administration. There is not much awareness about the technology and procedures used in these assays. The main objective of this review is to create awareness about the technology and procedure of these assays. PMID:27042485

  8. The NatCarb geoportal: Linking distributed data from the Carbon Sequestration Regional Partnerships

    USGS Publications Warehouse

    Carr, T.R.; Rich, P.M.; Bartley, J.D.

    2007-01-01

    The Department of Energy (DOE) Carbon Sequestration Regional Partnerships are generating the data for a "carbon atlas" of key geospatial data (carbon sources, potential sinks, etc.) required for rapid implementation of carbon sequestration on a broad scale. The NATional CARBon Sequestration Database and Geographic Information System (NatCarb) provides Web-based, nation-wide data access. Distributed computing solutions link partnerships and other publicly accessible repositories of geological, geophysical, natural resource, infrastructure, and environmental data. Data are maintained and enhanced locally, but assembled and accessed through a single geoportal. NatCarb, as a first attempt at a national carbon cyberinfrastructure (NCCI), assembles the data required to address technical and policy challenges of carbon capture and storage. We present a path forward to design and implement a comprehensive and successful NCCI. ?? 2007 The Haworth Press, Inc. All rights reserved.

  9. Interaction of HCl with a beta-NAT Surface: Prediction of the IR Spectrum

    NASA Astrophysics Data System (ADS)

    Martin-Llorente, B.; Escribano, R. M.; Fernandez-Torre, D.; Galvez, O.; Herrero, V. J.; Mate, B.; Moreno, M. A.

    2009-04-01

    Heterogeneous reactions that take place over the surface of polar stratospheric cloud (PSC) particles are thought to play an important role on stratospheric ozone depletion. Chlorine reservoir species, such as HCl and ClONO2, adsorbed on those particles, can be converted to reactive chlorine compounds, responsible for the destruction of ozone. The high temperature phase of nitric acid trihydrate (β-NAT) is one of the most important constituents of PSC. We present here a theoretical study of the system formed by HCl and β-NAT, by means of DFT calculations[1]. The adsorption of HCl on the most favourable site of the (001) surface of the β-NAT crystal[2] is simulated with a suitable model for the description of the vibrational properties of the system. Other possible adsorption sites will also be revised. An assignment of the different spectroscopic features, such as a small band at 2150 cm-1 attributed to the stretching of the adsorbed HCl molecule, is performed by comparing the predicted absorption spectrum with the experimental results[3] [1] J. M. Soler, E. Artacho, J. D. Gale, A. Garc

  10. Cysteamine effects on somatostatin, catecholamines, pineal NAT and melatonin in rats

    SciTech Connect

    Webb, S.M.; Champney, T.H.; Steger, R.W.; Vaughan, M.K.; Reiter, R.J.

    1986-03-01

    The thiol reagent cysteamine was administered to adult male rats with the aim of investigating its effect on different neural and pineal components. As expected, immunoreactive somatostatin decreased in the median eminence (ME) (p less than 0.05) and gastric antrum (p less than 0.05) after cysteamine; however, no significant change was observed in the pineal IRS content after drug treatment. A decrease in norepinephrine was observed in the ME (p less than 0.001), hypothalamus (p less than 0.001) and pineal gland (p less than 0.05), together with a rise in ME (p less than 0.005) and hypothalamic dopamine (p less than 0.005) content; these results are consistent with a dopamine-beta-hydroxylase inhibiting effect of cysteamine. No effect was observed on hypothalamic serotonin and 5-hydroxyindole-acetic acid content. Pineal N-acetyltransferase (NAT) activity was significantly higher (p less than 0.05) after cysteamine than after saline, but no statistically significant effect was observed on pineal melatonin content. The mechanism involved in the NAT rise is presumably not related to the known stimulatory effect of norepinephrine, which fell after cysteamine. It is suggested that cysteamine may act at an intracellular level, inhibiting NAT degradation, an effect demonstrated in vitro and thought to be related to a thiol:disulfide exchange mechanism.

  11. Consciousness: the radical plasticity thesis.

    PubMed

    Cleeremans, Axel

    2008-01-01

    In this chapter, I sketch a conceptual framework which takes it as a starting point that conscious and unconscious cognition are rooted in the same set of interacting learning mechanisms and representational systems. On this view, the extent to which a representation is conscious depends in a graded manner on properties such as its stability in time or its strength. Crucially, these properties are accrued as a result of learning, which is in turn viewed as a mandatory process that always accompanies information processing. From this perspective, consciousness is best characterized as involving (1) a graded continuum defined over "quality of representation", such that availability to consciousness and to cognitive control correlates with quality, and (2) the implication of systems of metarepresentations. A first implication of these ideas is that the main function of consciousness is to make flexible, adaptive control over behavior possible. A second, much more speculative implication, is that we learn to be conscious. This I call the "radical plasticity thesis"--the hypothesis that consciousness emerges in systems capable not only of learning about their environment, but also about their own internal representations of it.

  12. 5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit.

    PubMed

    Alarma-Estrany, Pilar; Crooke, Almudena; Pintor, Jesús

    2009-09-01

    Solid data support the idea that the MT(3) melatonin binding site is an enzyme, quinone reductase 2 (NQO2), rather than a membrane melatonin receptor. However, the melatonin analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduces intraocular pressure (IOP) via MT(3) melatonin receptors. Therefore, the aim of this work was to test whether the melatonin binding site, MT(3), is indeed the enzyme NQO2 in New Zealand rabbit eyes. To investigate this, the action of several substrates and inhibitors for NQO2 was compared to 5-MCA-NAT in their ability to modify IOP. Also, the effect of 5-MCA-NAT on IOP produced after NQO2 silencing by means of a siRNA was determinated. Altogether, the results led us to conclude that the in vivo effect of the MT(3) ligand 5-MCA-NAT on IOP is not mediated by the enzyme NQO2, suggesting the existence of another melatonin receptor.

  13. Cloning of an arylalkylamine N-acetyltransferase (aaNAT1) from Drosophila melanogaster expressed in the nervous system and the gut.

    PubMed Central

    Hintermann, E; Grieder, N C; Amherd, R; Brodbeck, D; Meyer, U A

    1996-01-01

    In insects, neurotransmitter catabolism, melatonin precursor formation, and sclerotization involve arylalkylamine N-acetyltransferase (aaNAT, EC 2.3.1.87) activity. It is not known if one or multiple aaNAT enzymes are responsible for these activities. We recently have purified an aaNAT from Drosophila melanogaster. Here, we report the cloning of the corresponding aaNAT cDNA (aaNAT1) that upon COS cell expression acetylates dopamine, tryptamine, and the immediate melatonin precursor serotonin. aaNAT1 represents a novel gene family unrelated to known acetyl-transferases, except in two weakly conserved amino acid motifs. In situ hybridization studies of aaNAT1 mRNA in embryos reveal hybridization signals in the brain, the ventral cord, the gut, and probably in oenocytes, indicating a broad tissue distribution of aaNAT1 transcripts. Moreover, in day/ night studies we demonstrate a diurnal rhythm of melatonin concentration without a clear-cut change in aaNAT1 mRNA levels. The data suggest that tissue-specific regulation of aaNAT1 may be associated with different enzymatic functions and do not exclude the possibility of additional aaNAT genes. Images Fig. 2 Fig. 3 Fig. 4 Fig. 5 PMID:8901578

  14. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1.

    PubMed

    Urano, T; Ihara, H; Umemura, K; Suzuki, Y; Oike, M; Akita, S; Tsukamoto, Y; Suzuki, I; Takada, A

    2001-07-06

    In this report, we demonstrate an interaction between subtilisin NAT (formerly designated BSP, or nattokinase), a profibrinolytic serine proteinase from Bacillus subtilis, and plasminogen activator inhibitor 1 (PAI-1). Subtilisin NAT was purified to homogeneity (molecular mass, 27.7 kDa) from a saline extract of B. subtilis (natto). Subtilisin NAT appeared to cleave active recombinant prokaryotic PAI-1 (rpPAI-1) into low molecular weight fragments. Matrix-assisted laser desorption/ionization in combination with time-of-flight mass spectroscopy and peptide sequence analysis revealed that rpPAI-1 was cleaved at its reactive site (P1-P1': Arg(346)-Met(347)). rpPAI-1 lost its specific activity after subtilisin NAT treatment in a dose-dependent manner (0.02-1.0 nm; half-maximal effect at approximately 0.1 nm). Subtilisin NAT dose dependently (0.06-1 nm) enhanced tissue-type plasminogen activator-induced fibrin clot lysis both in the absence of rpPAI-1 (48 +/- 1.4% at 1 nm) and especially in the presence of rpPAI-1 (78 +/- 2.0% at 1 nm). The enhancement observed in the absence of PAI-1 seems to be induced through direct fibrin dissolution by subtilisin NAT. The stronger enhancement by subtilisin NAT of rpPAI-1-enriched fibrin clot lysis seems to involve the cleavage and inactivation of active rpPAI-1. This mechanism is suggested to be important for subtilisin NAT to potentiate fibrinolysis.

  15. Genotype and allele frequencies of isoniazid-metabolizing enzymes NAT2 and GSTM1 in Latvian tuberculosis patients.

    PubMed

    Igumnova, Viktorija; Capligina, Valentina; Krams, Alvils; Cirule, Andra; Elferts, Didzis; Pole, Ilva; Jansone, Inta; Bandere, Dace; Ranka, Renate

    2016-07-01

    Pharmacogenomic testing of tuberculosis drug-metabolizing enzyme genes was proposed as a strategy to identify patients at risk for suboptimal responses to medications. However, variations of the genotype frequencies among ethnic groups exist and new alleles are been identified. The aim of this study was to identify polymorphisms of genes encoding metabolic enzymes NAT2 and GSTM1 in tuberculosis patients in Latvia and to estimate the frequency of NAT2 slow acetylator and GSTM1 null genotypes. In total, 85 DNA samples were genotyped, all individuals were Caucasian. An ethnic heterogeneity reflecting the multiethnic population of the country was observed. 49 patients were Latvians, 30 were Russians and 6 of other ethnicity. In total, 7 NAT2 alleles were identified: *4, *5, *6, *7, *11, *12, * and *13. The most frequent was the slow acetylation allele NAT2*6 (frequency 0.388) followed by the slow acetylation allele NAT2*5 and the rapid acetylation allele NAT2*4 (frequencies 0.306 and 0.194, respectively). The predominance of slow (51.8%) and intermediate (43.5%) acetylators compared with rapid acetylators (4.7%) was observed. The GSTM1 null genotype was detected in 48.2% of tuberculosis patients. When subgroup analysis was performed according to ethnicity, the results showed that neither NAT2 allele frequencies nor GSTM1 null genotype frequency did not differ significantly in TB patients of Latvian or Russian ethnicity. Overall, genotyping results were similar with previous reports of a NAT2 gene variation and GSTM1 null genotype frequency in Caucasians. Our findings have a contribution for the pharmacogenetics-based tuberculosis therapy in Latvia in future.

  16. Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene.

    PubMed

    Guo, Zhijun; Vath, Gregory M; Wagner, Carston R; Hanna, Patrick E

    2003-11-01

    Kinetic analysis of the inactiviation of hamster NAT1 by 2-(bromoacetylamino)fluorene (Br-AAF) and bromoacetanilide revealed that Br-AAF is an active site directed affinity label whereas bromoacetanilide acts as a bimolecular alkylating agent. ESI MS analysis of NAT1 treated with Br-AAF showed that a single molecule of 2-acetylaminofluorene had been incorporated. Proteolysis with pepsin followed by sequencing of adducted peptides by ESI MS/MS identified the modified residue as the catalytically essential Cys-68. ESI Q-TOF MS analysis of NAT1 that had been treated with bromoacetanilide resulted in identification of a monoadducted protein as the primary product and a diadducted protein as a minor product. Pepsin digestion of bromoacetanilide-inactivated NAT1 and sequencing by ESI MS/MS identified Cys-68 as the primary site of adduct formation. Additional proteolysis of the bromoacetanilide-treated NAT1 led to the identification of a second modified peptide which was adducted at Cys-44. The data reveal substantial differences in the interactions of small hydrophobic alkylating reagents with hamster NAT1.

  17. Heterogeneous formation of polar stratospheric clouds-nucleation of nitric acid trihydrate (NAT) in the arctic stratosphere

    NASA Astrophysics Data System (ADS)

    Hoyle, C. R.; Engel, I.; Luo, B. P.; Pitts, M. C.; Poole, L. R.; Grooß, J.-U.; Peter, T.

    2013-05-01

    Satellite based observations during the Arctic winter of 2009/2010 provide firm evidence that, in contrast to the current theory, the nucleation of nitric acid trihydrate (NAT) in the polar stratosphere does not only occur on preexisting ice particles. In order to explain the NAT clouds observed over the Arctic in mid December 2009, a heterogeneous nucleation mechanism is required, occurring on the surface of dust or meteoritic particles. For the first time, a detailed microphysical modelling of this NAT formation pathway has been carried out. Heterogeneous NAT formation was calculated along tens of thousands of trajectories, ending at Cloud Aerosol Lidar with Orthogonal Polarisation (CALIOP) observation points. Comparing the optical properties of the modelled NAT PSCs with these observations enables the thorough validation of a newly developed NAT nucleation parameterisation, which has been built into the Zurich Optical and Microphysical box Model (ZOMM). The parameterisation is based on active site theory and is simple to implement in models. It is shown that the new method is capable of reproducing observed PSCs very well, despite the varied conditions experienced by air parcels travelling along the different trajectories.

  18. The Master's Thesis in Applied Psychology Training.

    ERIC Educational Resources Information Center

    Shultz, Kenneth S.; Kottke, Janet L.

    1996-01-01

    Recommends the inclusion of a master's thesis in industrial and organizational psychology programs. Argues that the thesis serves several critical educational purposes and is relevant to applied psychology. Offers suggestions for increasing the relationship between the educational requirement and the professional tasks. (MJP)

  19. Introduction of the HAM-Nat examination--applicants and students admitted to the Medical Faculty in 2012-2014.

    PubMed

    Werwick, Katrin; Winkler-Stuck, Kirstin; Hampe, Wolfgang; Albrecht, Peggy; Robra, Bernt-Peter

    2015-01-01

    Hintergrund/Zielsetzung: Die Medizinische Fakultät Magdeburg hat zum Wintersemester 2012/13 einen Wissenstest zur Auswahl ihrer Studienbewerber eingeführt. Das Hamburger Auswahlverfahren für medizinische Studiengänge - Naturwissenschaftsteil (HAM-Nat) umfasst einen Multiple Choice-Test mit Fragen zu medizinisch relevanten Aspekten der Fächer Biologie, Physik, Chemie und Mathematik, der speziell für die Auswahl von Medizinbewerbern entwickelt wurde. Es wird untersucht, wie der HAM-Nat die Studierendenauswahl beeinflusst, aus welchen Gründen sich Studierende im Rahmen des Bewerbungsverfahrens für die Teilnahme am Test entscheiden und welche Erwartungen sie an das Studium haben.Methodik: Die Auswahlverfahren der Hochschule 2011 (ohne HAM-Nat) und 2012-2014 (mit HAM-Nat) werden verglichen. Aufbauend auf den Ergebnissen explorativer Interviews wurden erstmalig Studienanfänger des Wintersemesters 2013/2014 zur Wahl von Studienfach und Studienort sowie zu ihren Erwartungen an das Studium schriftlich befragt. Ergebnisse: Das um den HAM-Nat-Test erweiterte Auswahlverfahren wurde problemlos eingeführt. Der HAM-Nat hatte einen großen Einfluss auf die Auswahlentscheidung. Rund 65% der Zugelassenen hätten bei ausschließlicher Berücksichtigung der Abiturnote keinen Studienplatz erhalten. Männliche Bewerber zeigten im Durchschnitt bessere HAM-Nat-Ergebnisse als weibliche. Den Fragebogen beantworteten 147 von 191 Studienanfängern(77%). Für Studienbewerber aus Sachsen-Anhalt sind Hauptgründe für die Wahl der Landeshauptstadt die regionale Nähe, das vorhandene soziale Umfeld, die guten Studienbedingungen und der Wohlfühlcharakter am Studienort. Für die Mehrzahl der Bewerber, insbesondere für Bewerber aus anderen Bundesländern, standen dagegen die relativ guten Zulassungschancen in Magdeburg im Vordergrund. Schlussfolgerung: Die Medizinische Fakultät Magdeburg sieht im HAM-Nat ein geeignetes Instrument, um Bewerber mit hervorragenden naturwissenschaftlichen

  20. N-acetyltransferase (nat) is a critical conjunct of photoperiodism between the circadian system and endocrine axis in Antheraea pernyi.

    PubMed

    Mohamed, Ahmed A M; Wang, Qiushi; Bembenek, Jadwiga; Ichihara, Naoyuki; Hiragaki, Susumu; Suzuki, Takeshi; Takeda, Makio

    2014-01-01

    Since its discovery in 1923, the biology of photoperiodism remains a mystery in many ways. We sought the link connecting the circadian system to an endocrine switch, using Antheraea pernyi. PER-, CLK- and CYC-ir were co-expressed in two pairs of dorsolateral neurons of the protocerebrum, suggesting that these are the circadian neurons that also express melatonin-, NAT- and HIOMT-ir. The results suggest that a melatonin pathway is present in the circadian neurons. Melatonin receptor (MT2 or MEL-1B-R)-ir in PTTH-ir neurons juxtaposing clock neurons suggests that melatonin gates PTTH release. RIA showed a melatonin rhythm with a peak four hours after lights off in adult brain both under LD16:8 (LD) and LD12:12 (SD), and both the peak and the baseline levels were higher under LD than SD, suggesting a photoperiodic influence. When pupae in diapause were exposed to 10 cycles of LD, or stored at 4 °C for 4 months under constant darkness, an increase of NAT activity was observed when PTTH released ecdysone. DNA sequence upstream of nat contained E-boxes to which CYC/CLK could bind, and nat transcription was turned off by clk or cyc dsRNA. dsRNA(NAT) caused dysfunction of photoperiodism. dsRNA(PER) upregulated nat transcription as anticipated, based on findings in the Drosophila melanogaster circadian system. Transcription of nat, cyc and clk peaked at ZT12. RIA showed that dsRNA(NAT) decreased melatonin while dsRNA(PER) increased melatonin. Thus nat, a clock controlled gene, is the critical link between the circadian clock and endocrine switch. MT-binding may release PTTH, resulting in termination of diapause. This study thus examined all of the basic functional units from the clock: a photoperiodic counter as an accumulator of mRNA(NAT), to endocrine switch for photoperiodism in A. pernyi showing this system is self-complete without additional device especially for photoperiodism.

  1. Methamphetamine induces Shati/Nat8L expression in the mouse nucleus accumbens via CREB- and dopamine D1 receptor-dependent mechanism

    PubMed Central

    Uno, Kyosuke; Miyazaki, Toh; Sodeyama, Kengo; Miyamoto, Yoshiaki

    2017-01-01

    Shati/Nat8L significantly increased in the nucleus accumbens (NAc) of mice after repeated methamphetamine (METH) treatment. We reported that Shati/Nat8L overexpression in mouse NAc attenuated METH-induced hyperlocomotion, locomotor sensitization, and conditioned place preference. We recently found that Shati/Nat8L overexpression in NAc regulates the dopaminergic neuronal system via the activation of group II mGluRs by elevated N-acetylaspartylglutamate following N-acetylaspartate increase due to the overexpression. These findings suggest that Shati/Nat8L suppresses METH-induced responses. However, the mechanism by which METH increases the Shati/Nat8L mRNA expression in NAc is unclear. To investigate the regulatory mechanism of Shati/Nat8L mRNA expression, we performed a mouse Shati/Nat8L luciferase assay using PC12 cells. Next, we investigated the response of METH to Shati/Nat8L expression and CREB activity using mouse brain slices of NAc, METH administration to mice, and western blotting for CREB activity of specific dopamine receptor signals in vivo and ex vivo. We found that METH activates CREB binding to the Shati/Nat8L promoter to induce the Shati/Nat8L mRNA expression. Furthermore, the dopamine D1 receptor antagonist SCH23390, but not the dopamine D2 receptor antagonist sulpiride, inhibited the upregulation of Shati/Nat8L and CREB activities in the mouse NAc slices. Thus, the administration of the dopamine D1 receptor agonist SKF38393 increased the Shati/Nat8L mRNA expression in mouse NAc. These results showed that the Shati/Nat8L mRNA was increased by METH-induced CREB pathway via dopamine D1 receptor signaling in mouse NAc. These findings may contribute to development of a clinical tool for METH addiction. PMID:28319198

  2. Contribution of the N‐acetyltransferase 2 polymorphism NAT2*6A to age‐related hearing impairment

    PubMed Central

    Van Eyken, E; Van Camp, G; Fransen, E; Topsakal, V; Hendrickx, J J; Demeester, K; Van de Heyning, P; Mäki‐Torkko, E; Hannula, S; Sorri, M; Jensen, M; Parving, A; Bille, M; Baur, M; Pfister, M; Bonaconsa, A; Mazzoli, M; Orzan, E; Espeso, A; Stephens, D; Verbruggen, K; Huyghe, J; Dhooge, I; Huygen, P; Kremer, H; Cremers, C W R J; Kunst, S; Manninen, M; Pyykkö, I; Lacava, A; Steffens, M; Wienker, T F; Van Laer, L

    2007-01-01

    Background Age‐related hearing impairment (ARHI) is the most common sensory impairment in older people, affecting 50% of those aged 80 years. The proportion of older people is increasing in the general population, and as a consequence, the number of people affected with ARHI is growing. ARHI is a complex disorder, with both environmental and genetic factors contributing to the disease. The first studies to elucidate these genetic factors were recently performed, resulting in the identification of the first two susceptibility genes for ARHI, NAT2 and KCNQ4. Methods In the present study, the association between ARHI and polymorphisms in genes that contribute to the defence against reactive oxygen species, including GSTT1, GSTM1 and NAT2, was tested. Samples originated from seven different countries and were combined into two test population samples, the general European population and the Finnish population. Two distinct phenotypes for ARHI were studied, Zlow and Zhigh, representing hearing in the low and high frequencies, respectively. Statistical analysis was performed for single polymorphisms (GSTM1, GSTT1, NAT2*5A, NAT2*6A, and NAT2*7A), haplotypes, and gene–environment and gene–gene interactions. Results We found an association between ARHI and GSTT1 and GSTM1 in the Finnish population sample, and with NAT2*6A in the general European population sample. The latter finding replicates previously published data. Conclusion As replication is considered the ultimate proof of true associations in the study of complex disorders, this study provides further support for the involvement of NAT2*6A in ARHI. PMID:17513527

  3. Integrated management of thesis using clustering method

    NASA Astrophysics Data System (ADS)

    Astuti, Indah Fitri; Cahyadi, Dedy

    2017-02-01

    Thesis is one of major requirements for student in pursuing their bachelor degree. In fact, finishing the thesis involves a long process including consultation, writing manuscript, conducting the chosen method, seminar scheduling, searching for references, and appraisal process by the board of mentors and examiners. Unfortunately, most of students find it hard to match all the lecturers' free time to sit together in a seminar room in order to examine the thesis. Therefore, seminar scheduling process should be on the top of priority to be solved. Manual mechanism for this task no longer fulfills the need. People in campus including students, staffs, and lecturers demand a system in which all the stakeholders can interact each other and manage the thesis process without conflicting their timetable. A branch of computer science named Management Information System (MIS) could be a breakthrough in dealing with thesis management. This research conduct a method called clustering to distinguish certain categories using mathematics formulas. A system then be developed along with the method to create a well-managed tool in providing some main facilities such as seminar scheduling, consultation and review process, thesis approval, assessment process, and also a reliable database of thesis. The database plays an important role in present and future purposes.

  4. Special issue: Culham Thesis Prize winners

    NASA Astrophysics Data System (ADS)

    Ham, C. J.

    2015-01-01

    The Culham Thesis Prize is awarded annually to the nominee who has displayed an excellence in the execution of the scientific method as witnessed by the award of Doctor of Philosophy in Plasma Science from a UK or Irish university. The thesis content should exhibit significant new work and originality, clearly driven by the nominee, be well explained and demonstrate a good understanding of the subject. The prize is awarded at the Institute of Physics Plasma Physics Group Spring Conference and the prize winner gives an invited talk about their thesis work. The prize is sponsored by Culham Centre for Fusion Energy.

  5. A national look at carbon capture and storage-National carbon sequestration database and geographical information system (NatCarb)

    USGS Publications Warehouse

    Carr, T.R.; Iqbal, A.; Callaghan, N.; ,; Look, K.; Saving, S.; Nelson, K.

    2009-01-01

    The US Department of Energy's Regional Carbon Sequestration Partnerships (RCSPs) are responsible for generating geospatial data for the maps displayed in the Carbon Sequestration Atlas of the United States and Canada. Key geospatial data (carbon sources, potential storage sites, transportation, land use, etc.) are required for the Atlas, and for efficient implementation of carbon sequestration on a national and regional scale. The National Carbon Sequestration Database and Geographical Information System (NatCarb) is a relational database and geographic information system (GIS) that integrates carbon storage data generated and maintained by the RCSPs and various other sources. The purpose of NatCarb is to provide a national view of the carbon capture and storage potential in the U.S. and Canada. The digital spatial database allows users to estimate the amount of CO2 emitted by sources (such as power plants, refineries and other fossil-fuel-consuming industries) in relation to geologic formations that can provide safe, secure storage sites over long periods of time. The NatCarb project is working to provide all stakeholders with improved online tools for the display and analysis of CO2 carbon capture and storage data. NatCarb is organizing and enhancing the critical information about CO2 sources and developing the technology needed to access, query, model, analyze, display, and distribute natural resource data related to carbon management. Data are generated, maintained and enhanced locally at the RCSP level, or at specialized data warehouses, and assembled, accessed, and analyzed in real-time through a single geoportal. NatCarb is a functional demonstration of distributed data-management systems that cross the boundaries between institutions and geographic areas. It forms the first step toward a functioning National Carbon Cyberinfrastructure (NCCI). NatCarb provides access to first-order information to evaluate the costs, economic potential and societal issues of

  6. Structures and functions of insect arylalkylamine N-acetyltransferase (iaaNAT); a key enzyme for physiological and behavioral switch in arthropods

    PubMed Central

    Hiragaki, Susumu; Suzuki, Takeshi; Mohamed, Ahmed A. M.; Takeda, Makio

    2015-01-01

    The evolution of N-acetyltransfeases (NATs) seems complex. Vertebrate arylalkylamine N-acetyltransferase (aaNAT) has been extensively studied since it leads to the synthesis of melatonin, a multifunctional neurohormone prevalent in photoreceptor cells, and is known as a chemical token of the night. Melatonin also serves as a scavenger for reactive oxygen species. This is also true with invertebrates. NAT therefore has distinct functional implications in circadian function, as timezymes (aaNAT), and also xenobiotic reactions (arylamine NAT or simply NAT). NATs belong to a broader enzyme group, the GCN5-related N-acetyltransferase superfamily. Due to low sequence homology and a seemingly fast rate of structural differentiation, the nomenclature for NATs can be confusing. The advent of bioinformatics, however, has helped to classify this group of enzymes; vertebrates have two distinct subgroups, the timezyme type and the xenobiotic type, which has a wider substrate range including imidazolamine, pharmacological drugs, environmental toxicants and even histone. Insect aaNAT (iaaNAT) form their own clade in the phylogeny, distinct from vertebrate aaNATs. Arthropods are unique, since the phylum has exoskeleton in which quinones derived from N-acetylated monoamines function in coupling chitin and arthropodins. Monoamine oxidase (MAO) activity is limited in insects, but NAT-mediated degradation prevails. However, unexpectedly iaaNAT occurs not only among arthropods but also among basal deuterostomia, and is therefore more apomorphic. Our analyses illustrate that iaaNATs has unique physiological roles but at the same time it plays a role in a timezyme function, at least in photoperiodism. Photoperiodism has been considered as a function of circadian system but the detailed molecular mechanism is not well understood. We propose a molecular hypothesis for photoperiodism in Antheraea pernyi based on the transcription regulation of NAT interlocked by the circadian system

  7. Netzgenerierung und Finite-Elemente-Simulation muskulärer Strukturen unter Beachtung korrespondierender histologischer Schnittpräparate

    NASA Astrophysics Data System (ADS)

    Weichert, Frank; Schröder, Andreas; Landes, Constantin; Walczak, Lars; Müller, Heinrich; Wagner, Mathias

    In dieser Arbeit wird ein Verfahren zur Netzgenerierung und Finite-Elemente-Simulation muskulärer Strukturen vorgestellt. Eine Herausforderung liegt dabei in der Fusion der Simulationsergebnisse mit den Daten histologischer Schnittpräparate. Basierend auf segmentierten histologischen Daten wird eine Rekonstruktion der relevanten muskulären Strukturen mittels eines BCC-Tetraedernetzes initiiert. Dieses wird getriggert über einen Level-Set-Ansatz. Die Deformation des Muskels wird dann mittels eines hyperelastischen Materialgesetzes modelliert und mithilfe der Finite-Elemente-Methode simuliert. Anschließend erfolgt eine Projektion der Ergebnisse der Simulation auf die histologischen Schnittpräparate. Als Anwendungsfall wurden Daten abortiver Feten mit einer Spaltbildung im Bereich der Lippen-, Kiefer- und Gaumenregion herangezogen.

  8. Measurement of excitation functions in alpha induced reactions on natCu

    NASA Astrophysics Data System (ADS)

    Shahid, Muhammad; Kim, Kwangsoo; Kim, Guinyun; Zaman, Muhammad; Nadeem, Muhammad

    2015-09-01

    The excitation functions of 66,67,68Ga, 62,63,65Zn, 61,64Cu, and 58,60Co radionuclides in the natCu(α, x) reaction were measured in the energy range from 15 to 42 MeV by using a stacked-foil activation method at the MC-50 cyclotron of the Korean Institute of Radiological and Medical Sciences. The measured results were compared with the literature data as well as the theoretical values obtained from the TENDL-2013 and TENDL-2014 libraries based on the TALYS-1.6 code. The integral yields for thick targets of the produced radionuclides were also determined from the measured excitation functions and the stopping power of natural copper.

  9. The Legacy of Nat Sternberg: The Genesis of Cre-lox Technology.

    PubMed

    Yarmolinsky, Michael; Hoess, Ronald

    2015-11-01

    Cre-lox of bacteriophage P1 has become one of the most widely used tools for genetic engineering in eukaryotes. The origins of this tool date to more than 30 years ago when Nat L. Sternberg discovered the recombinase, Cre, and its specific locus of crossover, lox, while studying the maintenance of bacteriophage P1 as a stable plasmid. Recombinations mediated by Cre assist in cyclization of the DNA of infecting phage and in resolution of prophage multimers created by generalized recombination. Early in vitro work demonstrated that, although it shares similarities with the well-characterized bacteriophage λ integration, Cre-lox is in many ways far simpler in its requirements for carrying out recombination. These features would prove critical for its development as a powerful and versatile tool in genetic engineering. We review the history of the discovery and characterization of Cre-lox and touch upon the present direction of Cre-lox research.

  10. Experimental cross-sections for proton-induced nuclear reactions on natMo

    NASA Astrophysics Data System (ADS)

    Červenák, Jaroslav; Lebeda, Ondřej

    2016-08-01

    In the framework of the Co-ordinated Research Project of the IAEA, we measured in detail cross-sections of the nuclear reactions natMo(p,x)93gTc, 93mTc, 93m+gTc, 94gTc, 94mTc, 95gTc, 95mTc, 96m+gTc, 97mTc, 99mTc, 90Mo, 93mMo, 99Mo, 88gNb, 88mNb, 89gNb, 89mNb, 90m+gNb, 90m+gNbcum, 91mNb, 92mNb, 95gNb, 95mNb, 95m+gNb, 96Nb, 97m+gNb, 88m+gZrcum and 89m+gZrcum in the energy range of 6.9-35.8 MeV. The data for formation of 97mTc, 88gNb, 88mNb and 89mNb are reported for the first time. The obtained results were compared to the prediction of the nuclear reaction model code TALYS adopted from the TENDL-2015 library and to the previously published cross-sections. The thick target yields for all the radionuclides were calculated from the measured data. We suggest recommended cross-sections and thick target yields for the 100Mo(p,2n)99mTc, 100Mo(p,x)99Mo and natMo(p,x)96m+gTc nuclear reactions deduced from the selected experimental data.

  11. Functional programming interpreter. M. S. thesis

    SciTech Connect

    Robison, A.D.

    1987-03-01

    Functional Programming (FP) sup BAC87 is an alternative to conventional imperative programming languages. This thesis describes an FP interpreter implementation. Superficially, FP appears to be a simple, but very inefficient language. Its simplicity, however, allows it to be interpreted quickly. Much of the inefficiency can be removed by simple interpreter techniques. This thesis describes the Illinois Functional Programming (IFP) interpreter, an interactive functional programming implementation which runs under both MS-DOS and UNIX. The IFP interpreter allows functions to be created, executed, and debugged in an environment very similar to UNIX. IFP's speed is competitive with other interpreted languages such as BASIC.

  12. Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.

    PubMed

    Luetkemeyer, Anne F; Rosenkranz, Susan L; Lu, Darlene; Grinsztejn, Beatriz; Sanchez, Jorge; Ssemmanda, Michael; Sanne, Ian; McIlleron, Helen; Havlir, Diane V; Haas, David W

    2015-06-15

    In STRIDE, slow metabolizer CYP2B6 and NAT2 genotypes were each associated with increased plasma efavirenz concentrations during antituberculosis therapy. Concentrations were greater on therapy than off therapy in 58% with CYP2B6 and 93% with NAT2 slow metabolizer genotypes. Individuals with slow metabolizer genotypes in both genes had markedly elevated concentrations.

  13. Isolation of a thermotolerant photosynthetic bacterium, Rhodobacter sphaeroides Strain, NAT, and its capacity for oil and chemical oxygen demand removal at high temperatures.

    PubMed

    Yamaoka, Yosuke; Takeno, Kenji; Shinkawa, Hidenori; Noparatnaraporn, Napavarn; Sasaki, Ken

    2008-06-01

    A thermotolerant photosynthetic bacterium NAT identified as Rhodobacter sphaeroides was isolated. When alginate-immobilized cells of strain NAT were used in high-temperature treatment of artificial sewage wastewater containing oil, the chemical oxygen demand (COD) decreased by 80% and 76% of the oil was removed after 96 h of treatment at 55 degrees C. Lipase activity was observed in the culture.

  14. N-acetyltransferase (nat) Is a Critical Conjunct of Photoperiodism between the Circadian System and Endocrine Axis in Antheraea pernyi

    PubMed Central

    Bembenek, Jadwiga; Hiragaki, Susumu; Suzuki, Takeshi; Takeda, Makio

    2014-01-01

    Since its discovery in 1923, the biology of photoperiodism remains a mystery in many ways. We sought the link connecting the circadian system to an endocrine switch, using Antheraea pernyi. PER-, CLK- and CYC-ir were co-expressed in two pairs of dorsolateral neurons of the protocerebrum, suggesting that these are the circadian neurons that also express melatonin-, NAT- and HIOMT-ir. The results suggest that a melatonin pathway is present in the circadian neurons. Melatonin receptor (MT2 or MEL-1B-R)-ir in PTTH-ir neurons juxtaposing clock neurons suggests that melatonin gates PTTH release. RIA showed a melatonin rhythm with a peak four hours after lights off in adult brain both under LD16∶8 (LD) and LD12∶12 (SD), and both the peak and the baseline levels were higher under LD than SD, suggesting a photoperiodic influence. When pupae in diapause were exposed to 10 cycles of LD, or stored at 4°C for 4 months under constant darkness, an increase of NAT activity was observed when PTTH released ecdysone. DNA sequence upstream of nat contained E-boxes to which CYC/CLK could bind, and nat transcription was turned off by clk or cyc dsRNA. dsRNANAT caused dysfunction of photoperiodism. dsRNAPER upregulated nat transcription as anticipated, based on findings in the Drosophila melanogaster circadian system. Transcription of nat, cyc and clk peaked at ZT12. RIA showed that dsRNANAT decreased melatonin while dsRNAPER increased melatonin. Thus nat, a clock controlled gene, is the critical link between the circadian clock and endocrine switch. MT-binding may release PTTH, resulting in termination of diapause. This study thus examined all of the basic functional units from the clock: a photoperiodic counter as an accumulator of mRNANAT, to endocrine switch for photoperiodism in A. pernyi showing this system is self-complete without additional device especially for photoperiodism. PMID:24667367

  15. Peer Assessment in Thesis Oral Presentation

    ERIC Educational Resources Information Center

    Liow, Jong-Leng

    2008-01-01

    Peer assessment has been studied in various situations and actively pursued as a means by which students are given more control over their learning and assessment achievement. This study investigated the reliability of staff and student assessments in two oral presentations with limited feedback for a school-based thesis course in engineering…

  16. Callahan's Vulnerability Thesis and "Dissatisfaction Theory."

    ERIC Educational Resources Information Center

    Iannaccone, Laurence

    1996-01-01

    In discussing school superintendent vulnerability, the paper addresses diverse meanings among scholars of Callahan's vulnerability thesis, highlighting other articles within this theme issue. The paper reflects on discussions of Callahan's "Education and the Cult of Efficacy" before its 1962 publication and investigates the relation…

  17. Defining the Graduation Thesis & Identifying Student Needs.

    ERIC Educational Resources Information Center

    Hamatani, Eloise Pearson

    In Japanese colleges and universities, native speaker teachers in English departments are sometimes called on to teach courses that furnish English majors with the necessary tools to write their graduation theses in English. This study was undertaken at one university to determine what constitutes a graduation thesis, what aspects of the thesis…

  18. How I Chose My Thesis Advisor

    NASA Astrophysics Data System (ADS)

    Karimabadi, Homa

    2011-01-01

    Professor K. Papadopoulos, or Dennis, who we have all come to him as, has had a profound influence over my career as a scientist as well as my private life. Here I provide a brief account of the events that led me to Dennis as my PhD thesis advisor at University of Maryland and what that has meant to me.

  19. Writing a Structured Abstract for the Thesis

    ERIC Educational Resources Information Center

    Hartley, James

    2010-01-01

    This article presents the author's suggestions on how to improve thesis abstracts. The author describes two books on writing abstracts: (1) "Creating Effective Conference Abstracts and Posters in Biomedicine: 500 tips for Success" (Fraser, Fuller & Hutber, 2009), a compendium of clear advice--a must book to have in one's hand as one prepares a…

  20. Finding the Genesis for a Thesis

    ERIC Educational Resources Information Center

    Caroll, Joyce Armstrong

    2013-01-01

    This article describes a prewriting heuristics strategy that can help students find the genesis of their thesis. The 3 functions of the heuristic procedure are that it aids in retrieving relevant information stored in the mind; draws attention to important information that can be further researched or accessed; and prepares the mind for the…

  1. The Thesis, the Pendulum and the Battlefield

    ERIC Educational Resources Information Center

    Ameri, Amir

    2015-01-01

    The debate over the design thesis is often entangled in the dialectics of the practical and the theoretical. Whether the argument is waged and weighted in favour of a practical emphasis or a theoretical emphasis, or more insidious, a judicious balance between the two, what is inevitably assumed in the debate is the possibility of drawing and/or…

  2. Dancing the Thesis, Writing on the Body

    ERIC Educational Resources Information Center

    Mills, Dana

    2014-01-01

    This article explores the connection between dance and politics through reflection on the process of writing a thesis about those two fields. Similarities and differences in the educational and disciplinary processes of academic practice and dance training are brought out, while focusing on the technique developed by Martha Graham: in particular…

  3. Sinusoidal 50-Hz magnetic fields depress rat pineal NAT activity and serum melatonin. Role of duration and intensity of exposure.

    PubMed

    Selmaoui, B; Touitou, Y

    1995-01-01

    The purpose of this study was to determine whether the exposure to a 50-Hz sinusoidal magnetic field could influence serum melatonin concentration and pineal enzymes activities in rats. The effects of both duration and intensity of exposure were also looked at. Two groups of Wistar male rats were exposed to 50-Hz magnetic fields of either 1, 10 or 100 microT. The first group was exposed for 12 hours and the second for 30 days (18 hours per day). During this time the animals were kept under a standard 12:12 light: dark cycle with a temperature of 25 degrees C and a relative humidity of 45 to 50%. Control (Sham-exposed) animals were kept in a similar environment but without exposure to a magnetic field. The animals were sacrificed under red dim light. Serum melatonin concentration and pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) activities were studied. Long-term exposure to a magnetic field (10 and 100 microT) significantly depressed the nocturne peak of serum melatonin concentration and pineal NAT activity whereas no effect was observed on HIOMT activity. Short-term exposure depressed both pineal NAT activity and nocturnal serum melatonin concentration but only with the highest intensity used (100 microT). Our results suggest that sinusoidal magnetic fields alter the production of melatonin through an inhibition of pineal NAT activity. Both duration and intensity of exposure play an important role in this effect. This work shows that, 1) sinusoidal magnetic field depresses NAT activity as static magnetic field does whereas HIOMT activity remains unaltered whatever the type of experiment and the intensity used, 2) the effect observed is related to both the duration of exposure and the intensity of magnetic fields, 3) the sensitivity threshold to magnetic fields vary with the duration of exposure which strongly suggests a cumulative effect of sinusoidal magnetic fields on pineal function.

  4. Enhancing international earth science competence in natural hazards through 'geoNatHaz

    NASA Astrophysics Data System (ADS)

    Giardino, Marco; Clague, John J.

    2010-05-01

    "geoNatHaz" is a Transatlantic Exchange Partnership project (TEP 2009-2012) within the framework of the EU-Canada programme for co-operation in higher education, training, and youth. The project is structured to improve knowledge and skills required to assess and manage natural hazards in mountain regions. It provides student exchanges between European and Canadian universities in order to enhance international competence in natural hazard research. The university consortium is led by Simon Fraser University (Canada) and Università degli studi di Torino (Italy). Partner universities include the University of British Columbia, Queen's University, Università di Bologna, Université de Savoie, and the University of Athens. Université de Lausanne (Switzerland) supports the geoNatHaz advisory board through its bilateral agreements with Canadian partner universities. The geoNatHaz project promotes cross-cultural understanding and internationalization of university natural hazard curricula through common lectures, laboratory exercises, and field activities. Forty graduate students from the seven Canadian and European partner universities will benefit from the project between 2009 and 2012. Some students enrolled in graduate-level earth science and geologic engineering programs spend up to five months at the partner universities, taking courses and participating in research teams under the direction of project scientists. Other students engage in short-term (four-week) exchanges involving training in classic natural hazard case-studies in mountain regions of Canada and Europe. Joint courses are delivered in English, but complementary cultural activities are offered in the languages of the host countries. Supporting organizations offer internships and technical and scientific support. Students benefit from work-study programs with industry partners. Supporting organizations include government departments and agencies (Geological Survey of Canada; CNR-IRPI National

  5. Influence of mountain waves and NAT nucleation mechanisms on polar stratospheric cloud formation at local and synoptic scales during the 1999-2000 Arctic winter

    NASA Astrophysics Data System (ADS)

    Svendsen, S. H.; Larsen, N.; Knudsen, B.; Eckermann, S. D.; Browell, E. V.

    2005-03-01

    A scheme for introducing mountain wave-induced temperature pertubations in a microphysical PSC model has been developed. A data set of temperature fluctuations attributable to mountain waves as computed by the Mountain Wave Forecast Model (MWFM-2) has been used for the study. The PSC model has variable microphysics, enabling different nucleation mechanisms for nitric acid trihydrate, NAT, to be employed. In particular, the difference between the formation of NAT and ice particles in a scenario where NAT formation is not dependent on preexisting ice particles, allowing NAT to form at temperatures above the ice frost point, Tice, and a scenario, where NAT nucleation is dependent on preexisting ice particles, is examined. The performance of the microphysical model in the different microphysical scenarios and a number of temperature scenarios with and without the influence of mountain waves is tested through comparisons with lidar measurements of PSCs made from the NASA DC-8 on 23 and 25 January during the SOLVE/THESEO 2000 campaign in the 1999-2000 winter and the effect of mountain waves on local PSC production is evaluated in the different microphysical scenarios. Mountain waves are seen to have a pronounced effect on the amount of ice particles formed in the simulations. Quantitative comparisons of the amount of solids seen in the observations and the amount of solids produced in the simulations show the best correspondence when NAT formation is allowed to take place at temperatures above Tice. Mountain wave-induced temperature fluctuations are introduced in vortex-covering model runs, extending the full 1999-2000 winter season, and the effect of mountain waves on large-scale PSC production is estimated in the different microphysical scenarios. It is seen that regardless of the choice of microphysics ice particles only form as a consequence of mountain waves whereas NAT particles form readily as a consequence of the synoptic conditions alone if NAT nucleation above

  6. Genetics and culture: the geneticization thesis.

    PubMed

    ten Have, H A

    2001-01-01

    The concept of 'geneticization' has been introduced in the scholarly literature to describe the various interlocking and imperceptible mechanisms of interaction between medicine, genetics, society and culture. It is argued that Western culture currently is deeply involved in a process of geneticization. This process implies a redefinition of individuals in terms of DNA codes, a new language to describe and interpret human life and behavior in a genomic vocabulary of codes, blueprints, traits, dispositions, genetic mapping, and a gentechnological approach to disease, health and the body. This article analyses the thesis of 'geneticization'. Explaining the implications of the thesis, and discussing the critical refutations, it is argued that 'geneticization' primarily is a heuristic tool that can help to re-focus the moral debate on the implications of new genetic knowledge towards interpersonal relations, the power of medicine, the cultural context and social constraints, rather than emphasizing issues as personal autonomy and individual rights.

  7. The thesis of stages fourteen years later

    NASA Astrophysics Data System (ADS)

    Beeby, C. E.

    1980-12-01

    The author indicates the changes and additions he would make to his book ` The Quality of Education in Developing Countries' (1966) if he were re-writing it in 1980. He would make clearer that his primary interest is in a continuum of change, the process of growth of a school system, and that the `stages' are only a convenient non-mathematical artifact to make the thesis more useful to administrators and planners. In the light of more recent developments and experiences, he now gives new stress to the pluralism of objectives at the stage of Meaning, and discusses the political, social, cultural and financial reasons why a country may choose not to take the difficult step from stage III to stage IV. Recent forms of alternative education, particularly those embodying plans for lifelong education, offer some hope of bypassing his thesis of stages. More consideration is given to constraints other than that of teacher qualification, though the difficulty of changing the skills, habits, attitudes and purposes in the teaching profession remain the chief obstacle to qualitative growth. Particular attention is paid to `crash' programmes where processes that are, by their very nature, successive are compressed into simultaneous or almost simultaneous ones. Some implications of the thesis of stages for teacher training are briefly dealt with. Regarding the application of the thesis to secondary education, he maintains that a better model of growth would be one based on the capacity of secondary education to respond to the changing economic and social demands of the community. Finally, he suggests three methods of testing his hypotheses and pleads that more consideration be given to building up a body of educational, theory based on the experience of developing countries over the past three decades.

  8. Beyond Armageddon: Deterrence with less. Master's thesis

    SciTech Connect

    Kolbas, P.J.

    1991-06-01

    This thesis examines the implications for nuclear deterrence between the United States and the Soviet Union brought about by the dramatic changes in the strategic environment during the 1980s. Specifically, it examines the potential for a new criteria of deterrence at significantly lower levels of strategic weapons. The analysis indicates that a targeting strategy which emphasizes economic and industrial facilities will deter the Soviet Union. This targeting strategy allows for a reduction to 1500 strategic weapons while maintaining the robustness of nuclear deterrence between the United States and the Soviet Union. Using as its criteria arms race stability, breakout stability, crisis stability, verification, predictability, consequences of war, and the security of friends and allies, this thesis concludes that a force structure comprised of the Trident D-5 Submarine-launched ballistic missile and the B-2 bomber best ensures deterrence both against the Soviet Union and any other nuclear power regardless of changes in their political or ideological orientation. To provide maximum flexibility while negotiating the agreement and to hedge against a breakdown in U.S/Soviet relations prior to implementation, the thesis recommends a modernization program for U.S. strategic forces including funding for the restructured Strategic Defense Initiative which is now named Global Protection Against Limited Strikes.

  9. Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans.

    PubMed

    Wang, Hansong; Iwasaki, Motoki; Haiman, Christopher A; Kono, Suminori; Wilkens, Lynne R; Keku, Temitope O; Berndt, Sonja I; Tsugane, Shoichiro; Le Marchand, Loïc

    2015-01-01

    Heterocyclic aromatic amines formed in cooked meat may be an underlying mechanism for the red meat-colorectal cancer (CRC) association. These compounds require bioactivaction by N-acetyltransferase 2 (NAT2). An interaction effect between red meat consumption and NAT2 in increasing CRC risk has been inconsistently reported in whites. We investigated this interaction in two populations in which the high-activity rapid NAT2 phenotype is 10- and 2-fold more common than in whites. We meta-analyzed four studies of Japanese (2,217 cases, 3,788 controls) and three studies of African Americans (527 cases, 4,527 controls). NAT2 phenotype was inferred from an optimized seven-SNP genotyping panel. Processed and total red meat intakes were associated with an increased CRC risk in Japanese and in both ethnic groups combined (P's ≤ 0.002). We observed an interaction between processed meat intake and NAT2 in Japanese (P = 0.04), African Americans (P = 0.02), and in both groups combined (P = 0.006). The association of processed meat with CRC was strongest among individuals with the rapid NAT2 phenotype (combined analysis, OR for highest vs. lowest quartile: 1.62, 95% CI: 1.28-2.05; Ptrend = 8.0×10-5), intermediate among those with the intermediate NAT2 phenotype (1.29, 95% CI: 1.05-1.59; Ptrend = 0.05) and null among those with the slow phenotype (Ptrend = 0.45). A similar interaction was found for NAT2 and total red meat (Pinteraction = 0.03). Our findings support a role for NAT2 in modifying the association between red meat consumption and CRC in Japanese and African Americans.

  10. Simulations of the Vertical Redistribution of HNO3 by NAT or NAD PSCs: The Sensitivity to the Number of Cloud Particles Formed and the Cloud Lifetime

    NASA Technical Reports Server (NTRS)

    Jensen, Eric J.; Tabazadeh, Azadeh; Drdla, Katja; Toon, Owen B.; Gore, Warren J. (Technical Monitor)

    2000-01-01

    Recent satellite and in situ measurements have indicated that limited denitrification can occur in the Arctic stratosphere. In situ measurements from the SOLVE campaign indicate polar stratospheric clouds (PSCs) composed of small numbers (about 3 x 10^ -4 cm^-3) of 10-20 micron particles (probably NAT or NAD). These observations raise the issue of whether low number density NAT PSCs can substantially denitrify the air with reasonable cloud lifetimes. In this study, we use a one dimensional cloud model to investigate the verticle redistribution of HNO3 by NAT/NAD PSCs. The cloud formation is driven by a temperature oscillation which drops the temperature below the NAT/NAD formation threshold (about 195 K) for a few days. We assume that a small fraction of the available aerosols act as NAT nuclei when the saturation ratio of HNO3 over NAT(NAD) exceeds 10(l.5). The result is a cloud between about 16 and 20 km in the model, with NAT/NAD particle effective radii as large as about 10 microns (in agreement with the SOLVE data). We find that for typical cloud lifetimes of 2-3 days or less, the net depletion of HNO3 is no more than 1-2 ppbv, regardless of the NAT or NAD particle number density. Repeated passes of the air column through the cold pool build up the denitrification to 3-4 ppbv, and the cloud altitude steadily decreases due to the downward transport of nitric acid. Increasing the cloud lifetime results in considerably more effective denitrification, even with very low cloud particle number densities. As expected, the degree of denitrification by NAT clouds is much larger than that by NAD Clouds. Significant denitrification by NAD Clouds is only possible if the cloud lifetime is several days or more. The clouds also cause a local maximum HNO3 mixing ratio at cloud base where the cloud particles sublimate.

  11. A naturally occurring -263G/C variant of the human AA-NAT gene and overnight melatonin production.

    PubMed

    Ying, Grace Wang; Lee, Caroline Guat Lay; Lee, Edmund Jon Deoon

    2004-01-01

    Several lines of evidence show that the daily amount of melatonin produced differs greatly between individuals. Any polymorphism in the gene of arylalkylamine N-acetyltransferase (AA-NAT), a critical enzyme involved in melatonin biosynthesis, may contribute to the variability of melatonin production. The present study investigated the possible association between overnight melatonin excretion and a commonly occurring -263G/C polymorphism in the promoter region of the human AA-NAT gene. However, we found that -263G/C variant had no effect on the overnight 6-OHMS excretion. In this study, individual genotyping for -263G/C was determined by denaturing high performance liquid chromatography (DHPLC) and confirmed by sequencing. The overnight urinary 6-hydroxymelatonin sulfate (6-OHMS) excretion was quantified by enzyme-linked immunosorbent assay (ELISA).

  12. Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of Non-Hodgkin lymphoma

    PubMed Central

    Li, Yonghong; Zheng, Tongzhang; Kilfoy, Briseis A.; Lan, Qing; Zahm, Shelia; Holford, Theodore; Zhao, Ping; Dai, Min; Leaderer, Brian; Rothman, Nat; Zhang, Yawei

    2010-01-01

    The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs) and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's Lymphoma (NHL) in a population-based case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL. PMID:20131310

  13. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated caucasian individuals: Correlation with phenotypic activity

    SciTech Connect

    Cascorbi, I.; Drakoulis, N.; Brockmoeller, J.

    1995-09-01

    The polymorphic arylamine N-acetyltransferase (NAT2; EC2.3.1.5) is supposed to be a susceptibility factor for several drug side effects and certain malignancies. A group of 844 unrelated German subjects was genotyped for their acetylation type, and 563 of them were also phenotyped. Seven mutations of the NAT2 gene were evaluated by allele-specific PCR (mutation 341C to T) and PCR-RFLP for mutations at nt positions 191, 282, 481, 590, 803, and 857. From the mutation pattern eight different alleles, including the wild type coding for rapid acetylation and seven alleles coding for slow phenotype, were determined. Four hundred ninety-seven subjects had a genotype of slow acetylation (58.9%; 95% confidence limits 55.5%-62.2%). Phenotypic acetylation capacity was expressed as the ratio of 5-acetylamino-6-formylamino-3-methyluracil and 1-methylxanthine in urine after caffeine intake. Some 6.7% of the cases deviated in genotype and phenotype, but sequencing DNA of these probands revealed no new mutations. Furthermore, linkage pattern of the mutations was always confirmed, as tested in 533 subjects. In vivo acetylation capacity of homozygous wild-type subjects (NAT2{sup *}4/{sup *}4) was significantly higher than in heterozygous genotypes (P = .001). All mutant alleles showed low in vivo acetylation capacities, including the previously not-yet-defined alleles {sup *}5A, {sup *}5C, and {sup *}13. Moreover, distinct slow genotypes differed significantly among each other, as reflected in lower acetylation capacity of {sup *}6A, {sup *}7B, and {sup *}13 alleles than the group of {sup *}5 alleles. The study demonstrated differential phenotypic activity of various NAT2 genes and gives a solid basis for clinical and molecular-epidemiological investigations. 34 refs., 4 figs., 7 tabs.

  14. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase

    PubMed Central

    Chen, Ji-Yun; Liu, Liang; Cao, Chun-Ling; Li, Mei-Jun; Tan, Kemin; Yang, Xiaohan; Yun, Cai-Hong

    2016-01-01

    N-terminal acetylation (Nt-acetylation), carried out by N-terminal acetyltransferases (NATs), is a conserved and primary modification of nascent peptide chains. Naa60 (also named NatF) is a recently identified NAT found only in multicellular eukaryotes. This protein was shown to locate on the Golgi apparatus and mainly catalyze the Nt-acetylation of transmembrane proteins, and it also harbors lysine Nε-acetyltransferase (KAT) activity to catalyze the acetylation of lysine ε-amine. Here, we report the crystal structures of human Naa60 (hNaa60) in complex with Acetyl-Coenzyme A (Ac-CoA) or Coenzyme A (CoA). The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the β7-β8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. Remarkably, we found that the side-chain of Phe 34 can influence the position of the coenzyme, indicating a new regulatory mechanism involving enzyme, co-factor and substrates interactions. Moreover, structural comparison and biochemical studies indicated that Tyr 97 and His 138 are key residues for catalytic reaction and that a non-conserved β3-β4 long loop participates in the regulation of hNaa60 activity. PMID:27550639

  15. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase

    SciTech Connect

    Chen, Ji-Yun; Liu, Liang; Cao, Chun-Ling; Li, Mei-Jun; Tan, Kemin; Yang, Xiaohan; Yun, Caihong

    2016-08-23

    N-terminal acetylation (Nt-acetylation), carried out by N-terminal acetyltransferases (NATs), is a conserved and primary modification of nascent peptide chains. Naa60 (also named NatF) is a recently identified NAT found only in multicellular eukaryotes. This protein was shown to locate on the Golgi apparatus and mainly catalyze the Nt-acetylation of transmembrane proteins, and it also harbors lysine Nε -acetyltransferase (KAT) activity to catalyze the acetylation of lysine ε-amine. Here, we report the crystal structures of human Naa60 (hNaa60) in complex with Acetyl-Coenzyme A (Ac-CoA) or Coenzyme A (CoA). The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the β7-β8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. Remarkably, we found that the side-chain of Phe 34 can influence the position of the coenzyme, indicating a new regulatory mechanism involving enzyme, co-factor and substrates interactions. Moreover, structural comparison and biochemical studies indicated that Tyr 97 and His 138 are key residues for catalytic reaction and that a non-conserved β3-β4 long loop participates in the regulation of hNaa60 activity.

  16. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase

    DOE PAGES

    Chen, Ji-Yun; Liu, Liang; Cao, Chun-Ling; ...

    2016-08-23

    N-terminal acetylation (Nt-acetylation), carried out by N-terminal acetyltransferases (NATs), is a conserved and primary modification of nascent peptide chains. Naa60 (also named NatF) is a recently identified NAT found only in multicellular eukaryotes. This protein was shown to locate on the Golgi apparatus and mainly catalyze the Nt-acetylation of transmembrane proteins, and it also harbors lysine Nε -acetyltransferase (KAT) activity to catalyze the acetylation of lysine ε-amine. Here, we report the crystal structures of human Naa60 (hNaa60) in complex with Acetyl-Coenzyme A (Ac-CoA) or Coenzyme A (CoA). The hNaa60 protein contains an amphipathic helix following its GNAT domain that maymore » contribute to Golgi localization of hNaa60, and the β7-β8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. Remarkably, we found that the side-chain of Phe 34 can influence the position of the coenzyme, indicating a new regulatory mechanism involving enzyme, co-factor and substrates interactions. Moreover, structural comparison and biochemical studies indicated that Tyr 97 and His 138 are key residues for catalytic reaction and that a non-conserved β3-β4 long loop participates in the regulation of hNaa60 activity.« less

  17. The pioneer woman's view of migraine: Elizabeth Garrett Anderson's thesis "Sur la migraine".

    PubMed

    Wilkinson, M; Isler, H

    1999-01-01

    translate it but, after discussion, we decided on a joint effort (95% of the translation is by M.W.; very few details were changed, and some footnotes added for better understanding). We think that E.G.A.'s text is a classic, showing profound understanding, sound practical advice, and also, in its theoretical part, the limits of neurophysiological knowledge in Paris when Brown-Sequard was "charge des cours" there. We may add that in her various examinations she had to answer questions, in French, on the use of footprints by the police, the general nature of fishes, toxic fishes, electric fishes, cod liver oil, and the secretion of tears. She earned much applause from the public, which consisted of male French students, and the overt appreciation of Paul Broca, head examiner, and Dr Wurtz, the Dean of the Faculte de Médecine. The impact of her thesis in the 19th century was modest. It appears to be rather marginal in the German literature of the early 20th century, but it has imprinted the management of migraine at the City of London Migraine Clinic in the last thirty years. The importance of nutrition, regular meals, regular habits, the need to supplement analgesics with antiemetics, and the treatment of the attack with rest, and great quantities of hot tea, were certainly related to E.G.A.'s doctrine. The internationally prevailing recommendation to give antiemetics, and then only analgesics, as well as the combination of both in one tablet, may thus be traced back to E.G.A. via the teachings of M.W. and Nat Blau.

  18. Towards flash flood disaster prevention: the SciNetNat Haz proposal

    NASA Astrophysics Data System (ADS)

    Konstantinos, Papatheodorou; Elena, Tzanou; Carmen, Maftei; Ozgur, Kirca; Hafzullah, Aksoy

    2015-04-01

    Floods occur with a continuously increasing frequency due to climatic changes and cause serious damage in the wider Black Sea area, endangering human life and property. As societies continuously expand, these phenomena are expected to play an increasingly important role, blocking sustainable development unless properly tackled. Flash flood prevention seems at this point, to be the target of effectively mitigating the potential threat. Since in many cases, there is a cross-border character of the problem, collaborative efforts have to be made involving cooperation between countries. To this end, a variety of problems exist, including the "information gap" related to the unavailability of data and the multitude of methodologies used to assess flood hazard; a fact that renders comparison of hazard assessment results and cross border cooperation ineffective. An effort made within the context of the SciNetNatHaz project, suggests a two step approach to produce reliable the results which can lead to decision making regarding designing preventive measures. The first step aims at defining the flood prone areas on a regional scale, using geomorphometric models and readily available topographic data; thus overcoming the problem of data availability for any region of interest. The second step follows a vulnerability and risk assessment of the flood prone areas of interest and focuses on the calculation of flood parameters on a local scale using hydraulic models. Implementation of the full process is based on Open Source software tools so that it can be implemented with minimal costs by anyone interested. Implementation of the proposed procedure in three different cases in Greece and in Romania shows that it can provide accurate and reliable results to support decision making regarding the design of preventive measures. Keywords: Flash floods, hazard assessment, flood disaster prevention, HEC-RAS, SAGA GIS . Acknowledgements: This work is partially funded by the EU through the

  19. What Examiners Do: What Thesis Students Should Know

    ERIC Educational Resources Information Center

    Golding, Clinton; Sharmini, Sharon; Lazarovitch, Ayelet

    2014-01-01

    Although many articles have been written about thesis assessment, none provide a comprehensive, general picture of what examiners do as they assess a thesis. To synthesise this diverse literature, we reviewed 30 articles, triangulated their conclusions and identified 11 examiner practices. Thesis examiners tend to be broadly consistent in their…

  20. Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.

    PubMed

    Ariyannur, Prasanth S; Moffett, John R; Manickam, Pachiappan; Pattabiraman, Nagarajan; Arun, Peethambaran; Nitta, Atsumi; Nabeshima, Toshitaka; Madhavarao, Chikkathur N; Namboodiri, Aryan M A

    2010-06-04

    N-acetylaspartate (NAA) is a concentrated, neuron-specific brain metabolite routinely used as a magnetic resonance spectroscopy marker for brain injury and disease. Despite decades of research, the functional roles of NAA remain unclear. Biochemical investigations over several decades have associated NAA with myelin lipid synthesis and energy metabolism. However, studies have been hampered by an inability to identify the gene for the NAA biosynthetic enzyme aspartate N-acetyltransferase (Asp-NAT). A very recent report has identified Nat8l as the gene encoding Asp-NAT and confirmed that the only child diagnosed with a lack of NAA on brain magnetic resonance spectrograms has a 19-bp deletion in this gene. Based on in vitro Nat8l expression studies the researchers concluded that many previous biochemical investigations have been technically flawed and that NAA may not be associated with brain energy or lipid metabolism. In studies done concurrently in our laboratory we have demonstrated via cloning, expression, specificity for acetylation of aspartate, responsiveness to methamphetamine treatment, molecular modeling and comparative immunolocalization that NAT8L is the NAA biosynthetic enzyme Asp-NAT. We conclude that NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system, thus linking it to both lipid synthesis and energy metabolism.

  1. Functional characterization of NAT/NCS2 proteins of Aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide.

    PubMed

    Krypotou, Emilia; Scazzocchio, Claudio; Diallinas, George

    2015-02-01

    The Nucleobase-Ascorbate Transporter (NAT) family includes members in nearly all domains of life. Functionally characterized NAT transporters from bacteria, fungi, plants and mammals are ion-coupled symporters specific for the uptake of purines, pyrimidines and related analogues. The characterized mammalian NATs are specific for the uptake of L-ascorbic acid. In this work we identify in silico a group of fungal putative transporters, named UapD-like proteins, which represent a novel NAT subfamily. To understand the function and specificity of UapD proteins, we cloned and functionally characterized the two Aspergillus brasiliensis NAT members (named AbUapC and AbUapD) by heterologous expression in Aspergillus nidulans. AbUapC represents canonical NATs (UapC or UapA), while AbUapD represents the new subfamily. AbUapC is a high-affinity, high-capacity, H(+)/xanthine-uric acid transporter, which can also recognize other purines with very low affinity. No apparent transport function could be detected for AbUapD. GFP-tagging showed that, unlike AbUapC which is localized in the plasma membrane, AbUapD is ER-retained and degraded in the vacuoles, a characteristic of misfolded proteins. Chimeric UapA/AbUapD molecules are also turned-over in the vacuole, suggesting that UapD includes intrinsic peptidic sequences leading to misfolding. The possible evolutionary implication of such conserved, but inactive proteins is discussed.

  2. Characterization of ARGON-40 + Silver-Nat Reactions: Timescales and Emission Orders

    NASA Astrophysics Data System (ADS)

    Gelderloos, Carl James

    Studies have been made of ejectile coincidences resulting from ^{40}Ar + ^{nat}Ag reactions at bombarding energies of 17A-34A MeV. Correlations at both large and small relative angles are used to characterize the emission of light charged particles and fragments on a timescale of ~10^ {-22} s. Average delay times and emission orders between ejectiles are inferred by comparison to simulation calculations. Correlation functions in relative momentum, and spectra of the velocity differences between ejectiles emitted at small relative angles have been used to infer reaction dynamics. Trajectories of ejectile coincidences are particularly sensitive to the initial spatial and temporal relationship between the ejectiles and source. As the excitation energy of the emitter increases, the time delays between emissions decrease. The excitation energy deposited in central collisions increases from ~3 MeV per emitter nucleon at 17A MeV to nearly 6A MeV at 34A MeV. The measured delay times between ejectiles decrease steadily over this range. A simulation was developed to probe the degree of equilibration that is achieved by the composite nuclear system. It consists of a statistical model description of the emission of particles and a trajectory model calculation of the three-body interactions. Empirical lifetimes are substantially shorter than those predicted by model calculations, suggesting a regime in which partial, but not complete, equilibration is achieved. A novel method is also developed for measuring the average emission order for different ejectile pairs. The interactions between ejectiles differentiate between coincident events with different velocity relationships. At small relative angles these interactions are sufficiently strong to preferentially select events of a particular emission order. This method provides a new experimental observable with which to further constrain model descriptions. It is implemented to test for differences in average emission order

  3. Thermal Signature Identification System (TheSIS)

    NASA Technical Reports Server (NTRS)

    Merritt, Scott; Bean, Brian

    2015-01-01

    We characterize both nonlinear and high order linear responses of fiber-optic and optoelectronic components using spread spectrum temperature cycling methods. This Thermal Signature Identification System (TheSIS) provides much more detail than conventional narrowband or quasi-static temperature profiling methods. This detail allows us to match components more thoroughly, detect subtle reversible shifts in performance, and investigate the cause of instabilities or irreversible changes. In particular, we create parameterized models of athermal fiber Bragg gratings (FBGs), delay line interferometers (DLIs), and distributed feedback (DFB) lasers, then subject the alternative models to selection via the Akaike Information Criterion (AIC). Detailed pairing of components, e.g. FBGs, is accomplished by means of weighted distance metrics or norms, rather than on the basis of a single parameter, such as center wavelength.

  4. The Lenoir thesis revisited: Blumenbach and Kant.

    PubMed

    Zammito, John H

    2012-03-01

    Timothy Lenoir launched the historical study of German life science at the end of the 18th century with the claim that J. F. Blumenbach's approach was shaped by his reception of the philosophy of Immanuel Kant: a 'teleomechanism' that adopted a strictly 'regulative' approach to the character of organisms. It now appears that Lenoir was wrong about Blumenbach's understanding of Kant, for Blumenbach's Bildungstrieb entailed an actual empirical claim. Moreover, he had worked out the decisive contours of his theory and he had exerted his maximal influence on the so-called 'Göttingen School' before 1795, when Lenoir posits the main influence of Kant's thought took hold. This has crucial significance for the historical reconstruction of the German life sciences in the period. The Lenoir thesis can no longer serve as the point of departure for that reconstruction.

  5. Single link flexible beam testbed project. Thesis

    NASA Technical Reports Server (NTRS)

    Hughes, Declan

    1992-01-01

    This thesis describes the single link flexible beam testbed at the CLaMS laboratory in terms of its hardware, software, and linear model, and presents two controllers, each including a hub angle proportional-derivative (PD) feedback compensator and one augmented by a second static gain full state feedback loop, based upon a synthesized strictly positive real (SPR) output, that increases specific flexible mode pole damping ratios w.r.t the PD only case and hence reduces unwanted residual oscillation effects. Restricting full state feedback gains so as to produce a SPR open loop transfer function ensures that the associated compensator has an infinite gain margin and a phase margin of at least (-90, 90) degrees. Both experimental and simulation data are evaluated in order to compare some different observer performance when applied to the real testbed and to the linear model when uncompensated flexible modes are included.

  6. Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells.

    PubMed

    Rush, Jeffrey S; Matveev, Sergey; Guan, Ziqiang; Raetz, Christian R H; Waechter, C J

    2010-12-01

    During evolution the average chain length of polyisoprenoid glycosyl carrier lipids increased from C55 (prokaryotes) to C75 (yeast) to C95 (mammalian cells). In this study, the ability of the E. coli enzyme, undecaprenyl pyrophosphate synthase (UPPS), to complement the loss of the yeast cis-isoprenyltransferase in the rer2Δ mutant was tested to determine if (55)dolichyl phosphate (Dol-P) could functionally substitute in the protein N-glycosylation pathway for (75)Dol-P, the normal isoprenologue synthesized in S. cerevisiae. First, expression of UPPS in the yeast mutant was found to complement the growth and the hypoglycosylation of carboxypeptidase Y defects suggesting that the (55)polyprenyl-P-P intermediate was converted to (55)Dol-P and that (55)Dol-P could effectively substitute for (75)Dol-P in the biosynthesis and function of Man-P-Dol, Glc-P-Dol and Glc(3)Man(9)GlcNAc(2)-P-P-Dol (mature DLO) in the protein N-glycosylation pathway and glycosylphosphatidylinositol anchor assembly. In support of this conclusion, mutant cells expressing UPPS (1) synthesized (55)Dol-P based on MS analysis, (2) utilized (55)Dol-P to form Man-P-(55)Dol in vitro and in vivo, and (3) synthesized N-linked glycoproteins at virtually normal rates as assessed by metabolic labeling with [(3)H]mannose. In addition, an N-terminal GFP-tagged construct of UPPS was shown to localize to the endoplasmic reticulum of Chinese hamster ovary cells. Consistent with the synthesis of (55)Dol-P by the transfected cells, microsomes from the transfected cells synthesized the [(14)C](55)polyprenyl-P-P intermediate when incubated with [(14)C]isopentenyl pyrophosphate and [(3)H]Man-P-(55)Dol when incubated with GDP-[(3)H]Man. These results indicate that (C55)polyisoprenoid chains, significantly shorter than the natural glycosyl carrier lipid, can function in the transbilayer movement of DLOs in the endoplasmic reticulum of yeast and mammalian cells, and that conserved sequences in the cis

  7. Spectroscopic evidence of large aspherical β-NAT particles involved in denitrification in the December 2011 Arctic stratosphere

    NASA Astrophysics Data System (ADS)

    Woiwode, Wolfgang; Höpfner, Michael; Bi, Lei; Pitts, Michael C.; Poole, Lamont R.; Oelhaf, Hermann; Molleker, Sergej; Borrmann, Stephan; Klingebiel, Marcus; Belyaev, Gennady; Ebersoldt, Andreas; Griessbach, Sabine; Grooß, Jens-Uwe; Gulde, Thomas; Krämer, Martina; Maucher, Guido; Piesch, Christof; Rolf, Christian; Sartorius, Christian; Spang, Reinhold; Orphal, Johannes

    2016-07-01

    We analyze polar stratospheric cloud (PSC) signatures in airborne MIPAS-STR (Michelson Interferometer for Passive Atmospheric Sounding - STRatospheric aircraft) observations in the spectral regions from 725 to 990 and 1150 to 1350 cm-1 under conditions suitable for the existence of nitric acid trihydrate (NAT) above northern Scandinavia on 11 December 2011. The high-resolution infrared limb emission spectra of MIPAS-STR show a characteristic "shoulder-like" signature in the spectral region around 820 cm-1, which is attributed to the ν2 symmetric deformation mode of NO3- in β-NAT. Using radiative transfer calculations involving Mie and T-Matrix methods, the spectral signatures of spherical and aspherical particles are simulated. The simulations are constrained using collocated in situ particle measurements. Simulations assuming highly aspherical spheroids with aspect ratios (AR) of 0.1 or 10.0 and a lognormal particle mode with a mode radius of 4.8 µm reproduce the observed spectra to a high degree. A smaller lognormal mode with a mode radius of 2.0 µm, which is also taken into account, plays only a minor role. Within the scenarios analyzed, the best overall agreement is found for elongated spheroids with AR = 0.1. Simulations of spherical particles and spheroids with AR = 0.5 and 2.0 return results very similar to each other and do not allow us to reproduce the signature around 820 cm-1. The observed "shoulder-like" signature is explained by the combination of the absorption/emission and scattering characteristics of large highly aspherical β-NAT particles. The size distribution supported by our results corresponds to ˜ 9 ppbv of gas-phase equivalent HNO3 at the flight altitude of ˜ 18.5 km. The results are compared with the size distributions derived from the in situ observations, a corresponding Chemical Lagrangian Model of the Stratosphere (CLaMS) simulation, and excess gas-phase HNO3 observed in a nitrification layer directly below the observed PSC. The

  8. Trajectory Studies of Large HNO3-Containing PSC Particles in the Arctic: Evidence for the Role of NAT

    NASA Technical Reports Server (NTRS)

    McKinney, K. A.; Wennberg, P. O.; Dhaniyala, S.; Fahey, D. W.; Northway, M. J.; Kuenzi, K. F.; Kleinboehl, A.; Sinnhuber, M.; Kuellmann, H.; Bremer, H.; Mahoney, M. J.; Bui, T. P.

    2004-01-01

    Large (5 to >20 micron diameter) nitric-acid-containing polar stratospheric cloud (PSC) particles were observed in the Arctic stratosphere during the winter of 1999-2000. We use a particle growth and sedimentation model to investigate the environment in which these particles grew and the likely phase of the largest particles. Particle trajectory calculations show that, while simulated nitric acid dihydrate (NAD) particle sizes are significantly smaller than the observed maximum particle sizes, nitric acid trihydrate (NAT) particle trajectories are consistent with the largest observed particle sizes.

  9. N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study

    PubMed Central

    Adole, Prashant S.; Kharbanda, Parampreet S.; Sharma, Sadhna

    2016-01-01

    Background & objectives: Simultaneous administration of phenytoin and isoniazid (INH) in tuberculous meningitis (TBM) or tuberculoma patients with seizures results in higher plasma phenytoin level and thus phenytoin intoxication. N-acetyltransferase 2 (NAT2) enzyme catalyses two acetylation reactions in INH metabolism and NAT2 gene polymorphism leads to slow and rapid acetylators. The present study was aimed to evaluate the effect of allelic variants of N-acetyltransferase 2 (NAT2) gene as a predisposing factor for phenytoin toxicity in patients with TBM or tuberculoma having seizures, and taking INH and phenytoin simultaneously. Methods: Sixty patients with TBM or tuberculoma with seizures and taking INH and phenytoin simultaneously for a minimum period of seven days were included in study. Plasma phenytoin was measured by high performance liquid chromatography. NAT2 gene polymorphism was studied using restriction fragment length polymorphism and allele specific PCR. Results: The patients were grouped into those having phenytoin intoxication and those with normal phenytoin level, and also classified as rapid or slow acetylators by NAT2 genotyping. Genotypic analysis showed that of the seven SNPs (single nucleotide polymorphisms) of NAT2 gene studied, six mutations were found to be associated with phenytoin intoxication. For rs1041983 (C282T), rs1799929 (C481T), rs1799931 (G857A), rs1799930 (G590A), rs1208 (A803G) and rs1801280 (T341C) allelic variants, the proportion of homozygous mutant was higher in phenytoin intoxicated group than in phenytoin non-intoxicated group. Interpretation & conclusions: Homozygous mutant allele of NAT2 gene at 481site may act as a predisposing factor for phenytoin intoxication among TBM or tuberculoma patients having seizures. PMID:27488001

  10. Arylamine N-acetyl Transferase (NAT) in the blue secretion of Telescopium telescopium: xenobiotic metabolizing enzyme as a biomarker for detection of environmental pollution.

    PubMed

    Gorain, Bapi; Chakraborty, Sumon; Pal, Murari Mohan; Sarkar, Ratul; Samanta, Samir Kumar; Karmakar, Sanmoy; Sen, Tuhinadri

    2014-01-01

    Telescopium telescopium, a marine mollusc collected from Sundarban mangrove, belongs to the largest mollusca phylum in the world and exudes a blue secretion when stimulated mechanically. The blue secretion was found to metabolize (preferentially) para-amino benzoic acid, a substrate for N-acetyl transferase (NAT), thereby indicating acetyl transferase like activity of the secretion. Attempts were also made to characterise bioactive fraction of the blue secretion and to further use this as a biomarker for monitoring of marine pollution. NAT like enzyme from marine mollusc is a potential candidate for detoxification of different harmful chemicals. A partially purified extract of blue secretion was obtained by fractional precipitation with (NH4)2SO4. From different fractions obtained by precipitation, the 0-30% fraction (30S) displayed NAT like activity (using para amino benzoic acid as a substrate with para nitrophenyl phosphate or acetyl coenzyme A as acetyl group donors). Maximum NAT like enzyme activity was attained at 25°C and at a pH of 6. The enzyme activity was found to be inhibited by 5 mM phenyl methyl sulfonyl fluoride. The divalent metal ions reduced NAT like activity of 30S. Moreover, Cu(2+) and Zn(2+) (at concentration of 1 mM) completely inhibited NAT activity. The thermal stability and bench-top stability studies were performed and it was found that the enzyme was stable at room temperature for more than 24 hours. Results from the present study further indicate that heavy metal content in blue secretion gradually decreased from pre-monsoon to post-monsoon season, which also corresponded to the change in NAT like activity. Therefore, this article stresses the importance of biomarker research for monitoring pollution.

  11. Electron-magnon interaction in RNiBC (R=Er, Ho, Dy, Tb, and Gd) series of compounds based on magnetoresistance measurements

    NASA Astrophysics Data System (ADS)

    Fontes, M. B.; Trochez, J. C.; Giordanengo, B.; Bud'ko, S. L.; Sanchez, D. R.; Baggio-Saitovitch, E. M.; Continentino, M. A.

    1999-09-01

    We present a study of the transport and magnetic properties of a series of RNiBC compounds (R=Er, Ho, Dy, Tb, and Gd). All the materials investigated have long range magnetic order at sufficiently low temperatures. Magnetoresistance measurements are presented for a large range of temperatures (T) and magnetic fields (H). We show that below the critical temperature, the temperature dependence of the resistivity is determined by electron scattering due to the elementary excitations (spin waves) of the ordered magnetic phase and the values of the gap in the magnon spectra were derived. Finally we discuss the H×T phase diagram of these materials.

  12. Adapting a thesis to publication style: meeting editors' expectations.

    PubMed

    Johnson, S H

    1996-01-01

    Every year hundreds of thesis reports are completed by graduate students. Many of these end up on nursing journal editors' desks, only to be rejected. What characteristics of a thesis lead to rejection? How can authors develop quality research manuscripts? How can faculty teach graduate students the difference between a thesis and manuscript. This article answers these questions by providing advice from 15 critical care and research journal editors.

  13. Influence of mountain waves and NAT nucleation mechanisms on Polar Stratospheric Cloud formation at local and synoptic scales during the 1999 2000 Arctic winter

    NASA Astrophysics Data System (ADS)

    Svendsen, S. H.; Larsen, N.; Knudsen, B.; Eckermann, S. D.; Browell, E. V.

    2004-08-01

    A scheme for introducing mountain wave-induced temperature pertubations in a microphysical PSC model has been developed. A data set of temperature fluctuations attributable to mountain waves as computed by the Mountain Wave Forecast Model (MWFM-2) has been used for the study. The PSC model has variable microphysics, enabling different nucleation mechanisms for nitric acid trihydrate, NAT, to be employed. In particular, the difference between the formation of NAT and ice particles in a scenario where NAT formation is not dependent on preexisting ice particles, allowing NAT to form at temperatures above the ice frost point, Tice, and a scenario, where NAT nucleation is dependent on preexisting ice particles, is examined. The performance of the microphysical model in the different microphysical scenarios and a number of temperature scenarios with and without the influence of mountain waves is tested through comparisons with lidar measurements of PSCs made from the NASA DC-8 on 23 and 25 January during the SOLVE/THESEO 2000 campaign in the 1999-2000 winter and the effect of mountain waves on local PSC production is evaluated in the different microphysical scenarios. Mountain wave-induced temperature fluctuations are introduced in vortex-covering model runs, extending the full 1999-2000 winter season, and the effect of mountain waves on large-scale PSC production is estimated in the different microphysical scenarios.

  14. Production cross sections of short-lived silver radionuclides from natPd(p,xn) nuclear processes

    NASA Astrophysics Data System (ADS)

    Khandaker, Mayeen Uddin; Kim, Kwangsoo; Kim, Guinyun

    2012-03-01

    Production cross-sections of short-lived 103Ag, 104mAg and 104gAg radionuclides from proton-induced reactions on natural palladium (Pd) were measured up to 41 MeV by using a stacked-foil activation technique combined with high resolution γ-ray spectrometry. The present results are compared with the available literature values as well as theoretical data calculated by the TALYS and the ALICE-IPPE computer codes. Note that production cross-sections of the 104mAg radionuclide from natPd(p,xn) processes has been measured here for the first time. Physical thick target yields for the investigated radionuclides were deduced from the respective threshold energy to 41 MeV taking into account that the total energy is absorbed in the targets. Measured data of the short-lived 103Ag radionuclide are noteworthy due to its possible applications as a precursor for the indirect production of widely used therapeutic 103Pd radionuclide via natPd(p,xn)103Ag → 103Pd processes. On the other hand, the investigated 104Ag radionuclide finds importance due to its potential use as a diagnostic and positron emission tomography (PET) imaging analogue. Above all, measured data will enrich the literature database leading to various applications in science and technology.

  15. The Forman Thesis: 40 Years After

    NASA Astrophysics Data System (ADS)

    Carson, Cathryn; Kojevnikov, Alexei; Trischler, Helmuth

    Forty years ago, in 1971, Paul Forman published Weimar Culture, Causality, and Quantum Theory, 1918-1927: Adaptation by German Physicists and Mathematicians to a Hostile Intellectual Environment. His landmark study (too long, too thorough and too fundamental to be called simply an article) became immediately famous, and famously controversial. It has remained at the heart of debates about the historical relationship between science and culture ever since. The controversy surrounding the Forman Thesis was practically unavoidable, for Forman's work put forward and placed at the centre of a broader discussion the argument that the cultural values prevalent in a given place and time could influence the results of discipline-bound research, i.e. the very content of scientific knowledge. This idea, if still controversial, has since become commonly used in cultural studies of science, but at the time of its introduction it created uproar as it explicitly contradicted generally accepted and cherished beliefs about science. Yet tectonic shifts were already underway, if not always visible, that would eventually put those very beliefs into question. The Forman study both reflected and forwarded these shifts in our general perspectives on the nature and practice of science. Despite some heated objections to its findings, Forman's work has fundamentally changed directions of research in the history, sociology and philosophy of science and established itself as a classic in this group of fields, sometimes collectively called science studies. In subsequent decades it has been read and discussed in practically every graduate program that trains students in those fields, circulating in numerous copies and translated into many languages, while the original publication in the journal Historical Studies in the Physical Sciences has long become a bibliographic rarity…

  16. Reflections on how to write and organise a research thesis.

    PubMed

    Hardy, Sally; Ramjeet, Janet

    2005-01-01

    Writing up research projects and presenting a thesis are among the most challenging and time-consuming elements of the research process. The authors provide a structured guideline to help students, particularly those undertaking Master's degrees while still practising in clinical areas, to overcome the challenges of writing their thesis and produce a cogent, logical and reflective piece of work.

  17. Collaborating for Success: Team Teaching the Engineering Technical Thesis

    ERIC Educational Resources Information Center

    Keating, Terrence; Long, Mike

    2012-01-01

    This paper will examine the collaborative teaching process undertaken at College of the North Atlantic-Qatar (CNA-Q) by Engineering and the Communication faculties to improve the overall quality of engineering students' capstone projects known as the Technical Thesis. The Technical Thesis is divided into two separate components: a proposal stage…

  18. An Investigation of Generic Structures of Pakistani Doctoral Thesis Acknowledgements

    ERIC Educational Resources Information Center

    Rofess, Sakander; Mahmood, Muhammad Asim

    2015-01-01

    This paper investigates Pakistani doctoral thesis acknowledgements from genre analysis perspective. A corpus of 235 PhD thesis acknowledgements written in English was taken from Pakistani doctoral theses collected from eight different disciplines. HEC Research Repository of Pakistan was used as a data sources. The theses written by Pakistani…

  19. What Works for Doctoral Students in Completing Their Thesis?

    ERIC Educational Resources Information Center

    Lindsay, Siân

    2015-01-01

    Writing a thesis is one of the most challenging activities that a doctoral student must undertake and can represent a barrier to timely completion. This is relevant in light of current and widespread concerns regarding doctoral completion rates. This study explored thesis writing approaches of students post or near Ph.D. completion through…

  20. Calculation of the fission-fragment yields of the pre-actinide nuclei by the example of the natPb isotopes

    NASA Astrophysics Data System (ADS)

    Maslyuk, V. T.; Parlag, O. A.; Lendyel, O. I.; Marynets, T. I.; Romanyuk, M. I.; Shevchenko, O. S.; Ranyuk, Ju. Ju.; Dovbnya, A. M.

    2016-11-01

    The calculations of the fission-fragment yields (mass and charge spectra) carried out within the frameworks of the proposed statistical method for the pre-actinide nuclei by the example of natPb (20 isotopes) are presented. The role of neutron shells with N = 50 and N = 82 in realizing the single- and double-humped shape of the fission-fragment yields, respectively, for the neutron-deficit and neutron-excess Pb isotopes has been investigated. An explanation of the experimental results on the natPb fission was performed taking into account transformations to the ensemble of the long- and short-lived nuclear fragments.

  1. Inter-ethnic differences in genetic polymorphisms of xenobiotic-metabolizing enzymes (CYP1A1, CYP2D6, NAT1 and NAT2) in healthy populations: correlation with the functional in silico prediction.

    PubMed

    Khlifi, Rim; Ben Salah, Ghada; Chakroun, Amine; Hamza-Chaffai, Amel; Rebai, Ahmed

    2014-09-01

    Several studies have shown that many polymorphisms of the xenobiotic-metabolizing enzymes (XME) affect either enzymatic functions or are associated with various aspects of human health. Owing to the presence of these single nucleotide variants (SNVs), differences in detoxification capacity have been observed between many ethnicities. The aim of this investigation was to study the prevalence of four polymorphisms in XME among various ethnic groups. Attention was focused on polymorphisms of CYP2D6 (rs1058172, G>A, p.Arg365His), CYP1A1 (rs4646421, c.-26-728C>T), NAT1 (rs4921880, c.-85-1014T>A) and NAT2 (rs1208, A>G, p.Arg268Lys). These polymorphisms were analyzed in 261 healthy Tunisians individuals in comparison with different ethnic backgrounds from hapmap database. In addition, in silico functional prediction was also performed to determine the loss of function variants. Our results demonstrated that population's origins widely affect the genetic variability of XME enzymes and Tunisians show a characteristic pattern. In silico predictions showed a deleterious effect for p.Arg268Lys substitution on CYP2D6 function, findings confirmed its key role played in cancer susceptibility. These data show that detoxification genes structures depend on the studied population. This suggests that ethnic differences impact on disease risk or response to drugs and therefore should be taken into consideration in genetic association studies focusing on XME enzymes. Our results provide the first report on these SNV in Tunisian population and could be useful for further epidemiological investigations including targeted therapy.

  2. Instructable autonomous agents. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Huffman, Scott Bradley

    1994-01-01

    In contrast to current intelligent systems, which must be laboriously programmed for each task they are meant to perform, instructable agents can be taught new tasks and associated knowledge. This thesis presents a general theory of learning from tutorial instruction and its use to produce an instructable agent. Tutorial instruction is a particularly powerful form of instruction, because it allows the instructor to communicate whatever kind of knowledge a student needs at whatever point it is needed. To exploit this broad flexibility, however, a tutorable agent must support a full range of interaction with its instructor to learn a full range of knowledge. Thus, unlike most machine learning tasks, which target deep learning of a single kind of knowledge from a single kind of input, tutorability requires a breadth of learning from a broad range of instructional interactions. The theory of learning from tutorial instruction presented here has two parts. First, a computational model of an intelligent agent, the problem space computational model, indicates the types of knowledge that determine an agent's performance, and thus, that should be acquirable via instruction. Second, a learning technique, called situated explanation specifies how the agent learns general knowledge from instruction. The theory is embodied by an implemented agent, Instructo-Soar, built within the Soar architecture. Instructo-Soar is able to learn hierarchies of completely new tasks, to extend task knowledge to apply in new situations, and in fact to acquire every type of knowledge it uses during task performance - control knowledge, knowledge of operators' effects, state inferences, etc. - from interactive natural language instructions. This variety of learning occurs by applying the situated explanation technique to a variety of instructional interactions involving a variety of types of instructions (commands, statements, conditionals, etc.). By taking seriously the requirements of flexible

  3. Identification of the Substrate Recognition and Transport Pathway in a Eukaryotic Member of the Nucleobase-Ascorbate Transporter (NAT) Family

    PubMed Central

    Kosti, Vasiliki; Lambrinidis, George; Myrianthopoulos, Vassilios; Diallinas, George; Mikros, Emmanuel

    2012-01-01

    Using the crystal structure of the uracil transporter UraA of Escherichia coli, we constructed a 3D model of the Aspergillus nidulans uric acid-xanthine/H+ symporter UapA, which is a prototype member of the Nucleobase-Ascorbate Transporter (NAT) family. The model consists of 14 transmembrane segments (TMSs) divided into a core and a gate domain, the later being distinctly different from that of UraA. By implementing Molecular Mechanics (MM) simulations and quantitative structure-activity relationship (SAR) approaches, we propose a model for the xanthine-UapA complex where the substrate binding site is formed by the polar side chains of residues E356 (TMS8) and Q408 (TMS10) and the backbones of A407 (TMS10) and F155 (TMS3). In addition, our model shows several polar interactions between TMS1-TMS10, TMS1-TMS3, TMS8-TMS10, which seem critical for UapA transport activity. Using extensive docking calculations we identify a cytoplasm-facing substrate trajectory (D360, A363, G411, T416, R417, V463 and A469) connecting the proposed substrate binding site with the cytoplasm, as well as, a possible outward-facing gate leading towards the substrate major binding site. Most importantly, re-evaluation of the plethora of available and analysis of a number of herein constructed UapA mutations strongly supports the UapA structural model. Furthermore, modeling and docking approaches with mammalian NAT homologues provided a molecular rationale on how specificity in this family of carriers might be determined, and further support the importance of selectivity gates acting independently from the major central substrate binding site. PMID:22848666

  4. Comparative genomic survey, exon-intron annotation and phylogenetic analysis of NAT-homologous sequences in archaea, protists, fungi, viruses, and invertebrates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We have previously published extensive genomic surveys [1-3], reporting NAT-homologous sequences in hundreds of sequenced bacterial, fungal and vertebrate genomes. We present here the results of our latest search of 2445 genomes, representing 1532 (70 archaeal, 1210 bacterial, 43 protist, 97 fungal,...

  5. Association of GSTT1 non-null and NAT1 slow/rapid genotypes with von Hippel-Lindau tumour suppressor gene transversions in sporadic renal cell carcinoma.

    PubMed

    Gallou, C; Longuemaux, S; Deloménie, C; Méjean, A; Martin, N; Martinet, S; Palais, G; Bouvier, R; Droz, D; Krishnamoorthy, R; Junien, C; Béroud, C; Dupret, J M

    2001-08-01

    The von Hippel-Lindau (VHL) tumour suppressor gene is commonly mutated in renal cell carcinoma of clear cell type (CCRCC). We investigated the possible relationship between VHL mutations in sporadic CCRCC and polymorphism of genes encoding enzymes involved in carcinogen metabolism: two cytochrome P450 monooxygenases (CYP1A1 and CYP2D6), one NAD[P]H:quinone oxidoreductase (NQO1), three glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and two arylamine N-acetyltransferases (NAT1 and NAT2). We analysed DNA from tumour and nontumoural kidney tissue from 195 CCRCC patients. Single VHL mutations were identified in 88 patients and double mutations were present in two patients. Nine of 18 transversions were GC to TA, four were AT to TA, four were GC to CG and one was AT to CG. Ten of 19 transitions were GC to AT and nine were AT to GC. We also identified 53 frameshifts and two GC to AT at CpG. An excess of transversions was observed in a subset of patients with active GSTT1 [GSTT1 (+) genotype] and probably defective NAT1 (NAT1 S/R variant genotype). All 18 transversions were in GSTT1 (+) patients, whereas only 76% of transitions (P = 0.05) and 81% of the other mutations (P = 0.06) occurred in this genotype. We found that 28% of the transversions were in the NAT1 S/R genotype versus 12% of the transitions (P = 0.40) and 4% of the other mutations (P = 0.01). This suggests that pharmacogenetic polymorphisms may be associated with the type of acquired VHL mutation, which may modulate CCRCC development.

  6. [The importance of thesis in specialization courses in Medicine].

    PubMed

    Ramiro-H, Manuel; Cruz-A, Enrique

    2016-01-01

    The development of a thesis goes far beyond a mere compliance with the methodological requirements and evidence that students have sufficient knowledge that the profession demands. A thesis is usually the first academic and research work that students publish, it is also the result of commitment and dedication to the field of medicine in which they will be developing, which reflects motivations and interests, as well as their reflection to a specific problem.

  7. Importance and benefits of the doctoral thesis for medical graduates

    PubMed Central

    Giesler, Marianne; Boeker, Martin; Fabry, Götz; Biller, Silke

    2016-01-01

    Introduction: The majority of medical graduates in Germany complete a doctorate, even though a doctoral degree is not necessary for the practice of medicine. So far, little is known about doctoral candidates’ view on the individual benefit a doctoral thesis has for them. Consequently, this is the subject of the present investigation. Method: Data from surveys with graduates of the five medical faculties of Baden-Württemberg from the graduation years 2007/2008 (N=514) and 2010/2011 (N=598) were analysed. Results: One and a half years after graduating 53% of those interviewed had completed their doctorate. When asked about their motivation for writing a doctoral thesis, participants answered most frequently “a doctorate is usual” (85%) and “improvement of job opportunities” (75%), 36% said that an academic career has been their primary motive. Less than 10% responded that they used their doctoral thesis as a means to apply for a job. The proportion of graduates working in health care is equally large among those who have completed a thesis and those who have not. Graduates who pursued a thesis due to scientific interest are also currently more interested in an academic career and recognise more opportunities for research. An implicit benefit of a medical thesis emerged with regard to the self-assessment of scientific competences as those who completed a doctorate rated their scientific competencies higher than those who have not. Discussion: Although for the majority of physicians research interest is not the primary motivation for completing a doctorate, they might nevertheless achieve some academic competencies. For graduates pursuing an academic career the benefit of completing a medical thesis is more obvious. PMID:26958656

  8. Excitation functions of the natCr(p,x)44Ti, 56Fe(p,x)44Ti, natNi(p,x)44Ti and 93Nb(p,x)44Ti reactions at energies up to 2.6 GeV

    NASA Astrophysics Data System (ADS)

    Titarenko, Yu. E.; Batyaev, V. F.; Pavlov, K. V.; Titarenko, A. Yu.; Zhivun, V. M.; Chauzova, M. V.; Balyuk, S. A.; Bebenin, P. V.; Ignatyuk, A. V.; Mashnik, S. G.; Leray, S.; Boudard, A.; David, J. C.; Mancusi, D.; Cugnon, J.; Yariv, Y.; Nishihara, K.; Matsuda, N.; Kumawat, H.; Stankovskiy, A. Yu.

    2016-06-01

    The paper presents the measured cumulative yields of 44Ti for natCr, 56Fe, natNi and 93Nb samples irradiated by protons at the energy range 0.04-2.6 GeV. The obtained excitation functions are compared with calculations of the well-known codes: ISABEL, Bertini, INCL4.2+ABLA, INCL4.5+ABLA07, PHITS, CASCADE07 and CEM03.02. The predictive power of these codes regarding the studied nuclides is analyzed.

  9. Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food.

    PubMed

    Murakami, Keiko; Yamanaka, Naoki; Ohnishi, Katsunori; Fukayama, Minoru; Yoshino, Masataka

    2012-06-01

    Angiotensin I converting enzyme (ACE) was inhibited by the culture medium of Bacillus subtilis subsp. natto, which ferments boiled soy beans to natto, a Japanese traditional food. Subtilisin NAT (nattokinase) produced by B. subtilis also inhibited ACE, and the inhibition was markedly stimulated by heat treatment of subtilisin at 120 °C for 15 min. Inhibition of ACE by subtilisin was of a mixed type: the decrease in V(max) and the increase in K(m) value. SDS-polyacrylamide gel electrophoresis showed that heat treatment of subtilisin caused inactivation with fragmentation of the enzyme protein into small peptides. The inhibitory action of subtilisin was not due to an enzymatic action of protease, but may be ascribed to the potent ACE-inhibitory peptides such as LY and FY, amino acid sequences in subtilisin. HPLC-MS analysis of heat-inactivated subtilisin confirmed that LY and FY were liberated by fragmentation of the enzyme. Inhibition of ACE by subtilisin and its degradation peptides such as LY and FY may participate in the suppression of blood pressure by ingestion of natto.

  10. Rethinking neuroethics in the light of the extended mind thesis.

    PubMed

    Levy, Neil

    2007-09-01

    The extended mind thesis is the claim that mental states extend beyond the skulls of the agents whose states they are. This seemingly obscure and bizarre claim has far-reaching implications for neuroethics, I argue. In the first half of this article, I sketch the extended mind thesis and defend it against criticisms. In the second half, I turn to its neuroethical implications. I argue that the extended mind thesis entails the falsity of the claim that interventions into the brain are especially problematic just because they are internal interventions, but that many objections to such interventions rely, at least in part, on this claim. Further, I argue that the thesis alters the focus of neuroethics, away from the question of whether we ought to allow interventions into the mind, and toward the question of which interventions we ought to allow and under what conditions. The extended mind thesis dramatically expands the scope of neuroethics: because interventions into the environment of agents can count as interventions into their minds, decisions concerning such interventions become questions for neuroethics.

  11. Day/night fluctuations in melatonin content, arylalkylamine N-acetyltransferase activity and NAT mRNA expression in the CNS, peripheral tissues and hemolymph of the cockroach, Periplaneta americana.

    PubMed

    Bembenek, Jadwiga; Sehadova, Hana; Ichihara, Naoyuki; Takeda, Makio

    2005-01-01

    Melatonin content measured by a radioenzymatic assay in the brain of the American cockroach (Periplaneta americana) showed a day/night fluctuation with higher levels at night under LD 12:12. The activity of arylalkylamine N-acetyltransferase (NAT) in brain was also higher at night and this pattern continued in constant darkness. The results suggest that the rhythmicity in melatonin content can be caused by NAT. Melatonin content in hemolymph showed an even greater day/night difference, more than 12 times that in brain under LD 12:12. Melatonin levels in retina were also higher at night while NAT activity was not significantly higher at night than at daytime. Using a probe designed from NAT cloned from testes we performed Northern blot analysis of total RNA, which revealed that the level of NAT mRNA was higher in midgut, ovary and female accessory glands than in fat body and brain. The level of transcript in midgut was higher at night, but the levels in ovary and female accessory reproductive gland showed the opposite pattern. We also used the antibody to whole Drosophila melanogaster aaNAT1 protein, seeking a homologous antigen in the cephalic ganglia. NAT-like antigen was detected in several restricted populations of cells in the brain that were partially co-localized with PER-like antigen. The results suggest that NAT exists in multiple forms in various tissues of the cockroach and that its functions and regulations can vary among tissues. The results in the brain led to the conclusion that NAT could be a clock-controlled gene functioning as an output regulator of the circadian clock.

  12. Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice.

    PubMed

    Miyamoto, Yoshiaki; Ishikawa, Yudai; Iegaki, Noriyuki; Sumi, Kazuyuki; Fu, Kequan; Sato, Keiji; Furukawa-Hibi, Yoko; Muramatsu, Shin-Ichi; Nabeshima, Toshitaka; Uno, Kyosuke; Nitta, Atsumi

    2014-08-01

    A novel N-acetyltransferase, Shati/Nat8l, was identified in the nucleus accumbens (NAc) of mice with methamphetamine (METH) treatment. Previously we reported that suppression of Shati/Nat8l enhanced METH-induced behavioral alterations via dopaminergic neuronal regulation. However, the physiological mechanisms of Shati/Nat8l on the dopaminergic system in the brain are unclear. In this study, we injected adeno-associated virus (AAV) vector containing Shati/Nat8l into the NAc or dorsal striatum (dS) of mice, to increase Shati/Nat8l expression. Overexpression of Shati/Nat8l in the NAc, but not in the dS, attenuated METH-induced hyperlocomotion, locomotor sensitization, and conditioned place preference in mice. Moreover, the Shati/Nat8l overexpression in the NAc attenuated the elevation of extracellular dopamine levels induced by METH in in vivo microdialysis experiments. These behavioral and neurochemical alterations due to Shati/Nat8l overexpression in the NAc were inhibited by treatment with selective group II metabotropic glutamate receptor type 2 and 3 (mGluR2/3) antagonist LY341495. In the AAV vector-injected NAc, the tissue contents of both N-acetylaspartate and N-acetylaspartylglutamate (NAAG), endogenous mGluR3 agonist, were elevated. The injection of peptidase inhibitor of NAAG or the perfusion of NAAG itself reduced the basal levels of extracellular dopamine in the NAc of naive mice. These results indicate that Shati/Nat8l in the NAc, but not in the dS, plays an important suppressive role in the behavioral responses to METH by controlling the dopaminergic system via activation of group II mGluRs.

  13. Supervisors' perspective on medical thesis projects and dropout rates: survey among thesis supervisors at a large German university hospital

    PubMed Central

    Can, Elif; Richter, Felicitas; Valchanova, Ralitsa; Dewey, Marc

    2016-01-01

    Objectives To identify underlying causes for failure of medical thesis projects and the constantly high drop-out rate in Germany from the supervisors' perspective and to compare the results with the students' perspective. Setting Cross-sectional survey. Online questionnaire for survey of medical thesis supervisors among the staff of Charité—Universitätsmedizin Berlin, Germany. Published, earlier longitudinal survey among students for comparison. Participants 1069 thesis supervisors participated. Data extraction and synthesis Data are presented using descriptive statistics, and the χ2 test served to compare the results among supervisors with the earlier data from the longitudinal survey of doctoral students. Primary and secondary outcomes Not applicable. This survey is an observational study. Results Of 3653 potential participants, 1069 (29.3%) supervising 3744 doctoral candidates participated in the study. Supervisors considered themselves to be highly motivated and to offer adequate supervision. On the other hand, 87% stated that they did not feel well prepared for thesis supervision. Supervisors gave lack of timeliness of doctoral students and personal differences (p=0.024 and p=0.001) as the main reasons for terminating thesis projects. Doctoral students predominantly mentioned methodological problems and difficult subjects as critical issues (p=0.001 and p<0.001). Specifically, students felt ill prepared for the statistical part of their research—49.5% stated that they never received statistical assistance, whereas 97% of supervisors claimed to help their students with statistical analysis. Conclusions The authors found that both thesis supervisors and medical students feel ill prepared for their roles in the process of a medical dissertation. Contradictory reasons for terminating medical thesis projects based on supervisors' and students' self-assessment suggest a lack of communication and true scientific collaboration between supervisors and doctoral

  14. Rough Endoplasmic Reticulum (rER) Trafficking Errors by Different Classes of Mutant DSPP Cause the Dominant Negative Effects in both Dentinogenesis Imperfecta and Dentin Dysplasia by Entrapping Normal DSPP

    PubMed Central

    von Marschall, Zofia; Mok, Seeun; Phillips, Matthew D.; McKnight, Dianalee A.; Fisher, Larry W.

    2012-01-01

    Families with nonsyndromic dentinogenesis imperfecta (DGI) and the milder, dentin dysplasia (DD), have mutations in one allele of the dentin sialophosphoprotein (DSPP) gene. Because loss of a single Dspp allele in mice (and likely, humans) causes no dental phenotype, the mechanism(s) underling the dominant-negative effects were investigated. DSPP mutations occur in three classes. (The first class, the mid-leader missense mutation, Y6D, was not investigated in this report.) All other 5' mutations of DSPP result in changes/loss in the first three amino acids (IPV) of mature DSPP or, for A15V, some retention of the hydrophobic leader sequence. All of this second class of mutations caused mutant DSPP to be retained in the rER of transfected HEK293 cells. Trafficking out of the rER by co-expressed normal DSPP was reduced in a dose-responsive manner, probably due to formation of Ca2+-dependent complexes with the retained mutant DSPP. IPV-like sequences begin many secreted Ca2+-binding proteins, and changing the third amino acid to the charged aspartate (D) in three other acidic proteins also caused increased rER accumulation. Both the leader-retaining A15V and the long string of hydrophobic amino acids resulting from all known frameshift mutations within the 3'-encoded Ca2+-binding repeat domain (third class of mutations) caused retention by association of the mutant proteins with rER membranes. More 5' frameshift mutations result in longer mutant hydrophobic domains but the milder phenotype, DD, probably due to lower effectiveness of the remaining, shorter Ca2+-binding domain in capturing normal DSPP protein within the rER. This study presents evidence of a shared underlying mechanism of capturing of normal DSPP by two different classes of DSPP mutations and offers an explanation for the mild (DD-II) versus severe (DGI-II & III) nonsyndromic dentin phenotypes. Evidence is also presented that many acidic, Ca2+-binding proteins may use the same IPV-like receptor

  15. Independent isotopic yields in 25 MeV and 50 MeV proton-induced fission of natU

    NASA Astrophysics Data System (ADS)

    Penttilä, H.; Gorelov, D.; Elomaa, V.-V.; Eronen, T.; Hager, U.; Hakala, J.; Jokinen, A.; Kankainen, A.; Karvonen, P.; Moore, I. D.; Parkkonen, J.; Peräjärvi, K.; Pohjalainen, I.; Rahaman, S.; Rinta-Antila, S.; Rissanen, J.; Rubchenya, V. A.; Saastamoinen, A.; Simutkin, V.; Sonoda, T.; Weber, C.; Voss, A.; Äystö, J.

    2016-04-01

    Independent isotopic yields for elements from Zn to La in the 25 MeV proton-induced fission of {}^{nat}U were determined with the JYFLTRAP facility. In addition, isotopic yields for Zn, Ga, Rb, Sr, Zr, Pd and Xe in the 50 MeV proton-induced fission of {}^{nat}U were measured. The deduced isotopic yield distributions are compared with a Rubchenya model, the GEF model with universal parameters and the semi-empirical Wahl model. Of these, the Rubchenya model gives the best overall agreement with the obtained data. Combining the isotopic yield data with mass yield data to obtain the absolute independent yields was attempted. The result depends on the mass yield distribution.

  16. A simple and cost-saving approach to optimize the production of subtilisin NAT by submerged cultivation of Bacillus subtilis natto.

    PubMed

    Ku, Ting-Wei; Tsai, Ruei-Lan; Pan, Tzu-Ming

    2009-01-14

    Subtilisin NAT, formerly designated nattokinase or subtilisin BSP, is a potent cardiovascular drug because of its strong fibrinolytic activity and safety. In this study, one Bacillus subtilis natto strain with high fibrinolytic activity was isolated. We further studied the optimal conditions for subtilisin NAT production by submerged cultivation and three variables/three levels of response surface methodology (RSM) using various inoculum densities, glucose concentrations, and defatted soybean concentrations as the three variables. According to the RSM analysis, while culturing by 2.93% defatted soybean, 1.75% glucose, and 4.00% inoculum density, we obtained an activity of 13.78 SU/mL. Processing the batch fermentation with this optimal condition, the activity reached 13.69 SU/mL, which is equal to 99.3% of the predicted value.

  17. Active cigarette smoking and the risk of breast cancer at the level of N-acetyltransferase 2 (NAT2) gene polymorphisms.

    PubMed

    Kasajova, Petra; Holubekova, Veronika; Mendelova, Andrea; Lasabova, Zora; Zubor, Pavol; Kudela, Erik; Biskupska-Bodova, Kristina; Danko, Jan

    2016-06-01

    The aim of our study was to assess the correlation between the tobacco exposure and NAT2 gene (rs1041983 C/T, rs1801280 T/C, rs1799930 G/A) polymorphisms in association with breast cancer development. We wanted to determine the prognostic clinical importance of these polymorphisms in association with smoking and breast cancer. For the detection of possible association between smoking, NAT2 gene polymorphisms, and the risk of breast cancer, we designed a case-controlled study with 198 patients enrolled, 98 breast cancer patients and 100 healthy controls. Ten milliliters of peripheral blood from the cubital vein was withdrawn from every patient. The HRM (high resolution melting) analysis was used for the detection of three abovementioned NAT2 gene polymorphisms. When comparing a group of women smoking more than 5 cigarettes a day with the patients smoking fewer than 5 cigarettes a day, we found out that if women were the carriers of aberrant AA genotype for rs1799930, the first group of women had higher risk of breast carcinoma than the second group. If patients were the carriers of aberrant TT genotype for rs1041983, for rs1801280CC genotype, and rs1799930AA genotype and they smoked more than 5 cigarettes a day, they had higher risk of malignant breast disease than never-smoking women. Our results confirm the hypothesis that NAT2 gene polymorphisms (rs1041983 C/T, rs1801280 T/C, and rs1799930 G/A) in association with long-period active smoking could be the possible individual risk-predicting factors for breast cancer development in the population of Slovak women.

  18. Identification of ta-siRNAs and Cis-nat-siRNAs in Cassava and Their Roles in Response to Cassava Bacterial Blight

    PubMed Central

    Quintero, Andrés; Pérez-Quintero, Alvaro L.; López, Camilo

    2013-01-01

    Trans-acting small interfering RNAs (ta-siRNAs) and natural cis-antisense siRNAs (cis-nat-siRNAs) are recently discovered small RNAs (sRNAs) involved in post-transcriptional gene silencing. ta-siRNAs are transcribed from genomic loci and require processing by microRNAs (miRNAs). cis-nat-siRNAs are derived from antisense RNAs produced by the simultaneous transcription of overlapping antisense genes. Their roles in many plant processes, including pathogen response, are mostly unknown. In this work, we employed a bioinformatic approach to identify ta-siRNAs and cis-nat-siRNAs in cassava from two sRNA libraries, one constructed from healthy cassava plants and one from plants inoculated with the bacterium Xanthomonas axonopodis pv. manihotis (Xam). A total of 54 possible ta-siRNA loci were identified in cassava, including a homolog of TAS3, the best studied plant ta-siRNA. Fifteen of these loci were induced, while 39 were repressed in response to Xam infection. In addition, 15 possible cis-natural antisense transcript (cis-NAT) loci producing siRNAs were identified from overlapping antisense regions in the genome, and were found to be differentially expressed upon Xam infection. Roles of sRNAs were predicted by sequence complementarity and our results showed that many sRNAs identified in this work might be directed against various transcription factors. This work represents a significant step toward understanding the roles of sRNAs in the immune response of cassava. PMID:23665476

  19. Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1

    PubMed Central

    Siegmund, Werner; Modess, Christiane; Scheuch, Eberhard; Methling, Karen; Keiser, Markus; Nassif, Ali; Rosskopf, Dieter; Bednarski, Patrick J; Borlak, Jürgen; Terhaag, Bernd

    2015-01-01

    Aims The rare association of flupirtine with liver injury is most likely caused by reactive quinone diimines and their oxidative formation may be influenced by the activities of N-acetyltransferases (NAT) that conjugate the less toxic metabolite D13223, and by glucuronosyltransferases (UGT) and glutathione S-transferases (GST) that generate stable terminal glucuronides and mercapturic acid derivatives, respectively. The influence of genetic polymorphisms of NAT2, UGT1A1 and GSTP1 on generation of the terminal mercapturic acid derivatives and analgesic effects was evaluated to identify potential genetic risk factors for hepatotoxicity of flupirtine. Methods Metabolic disposition of flupirtine was measured after intravenous administration (100 mg), after swallowing an immediate-release (IR) tablet (100 mg) and after repeated administration of modified release (MR) tablets (400 mg once daily 8 days) in 36 selected healthy subjects. Analgesic effects were measured using pain models (delayed onset of muscle soreness, electric pain). Results Flupirtine IR was rapidly but incompletely absorbed (∼72%). Repeated administration of flupirtine MR showed lower bioavailability (∼60%). Approximately 12% of bioavailable flupirtine IR and 8% of bioavailable flupiritine MR was eliminated as mercapturic acid derivatives into the urine independent of the UGT1A1, NAT2 and GSTP1 genotype. Carriers of variant GSTP1 alleles showed lower bioavailability but increased intestinal secretion of flupirtine and increased efficiency in experimental pain. Flupirtine was not a substrate for ABCB1 and ABCC2. Conclusions Formation of mercapturic acid derivatives is a major elimination route for flupirtine in man. However, the theoretically toxic pathway is not influenced by the frequent polymorphisms of UGT1A1, NAT2 and GSTP1. PMID:25264565

  20. Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

    PubMed

    Dik, Vincent K; Bueno-de-Mesquita, H B As; Van Oijen, Martijn G H; Siersema, Peter D; Uiterwaal, Cuno S P M; Van Gils, Carla H; Van Duijnhoven, Fränzel J B; Cauchi, Stéphane; Yengo, Loic; Froguel, Philippe; Overvad, Kim; Bech, Bodil H; Tjønneland, Anne; Olsen, Anja; Boutron-Ruault, Marie-Christine; Racine, Antoine; Fagherazzi, Guy; Kühn, Tilman; Campa, Daniele; Boeing, Heiner; Aleksandrova, Krasimira; Trichopoulou, Antonia; Peppa, Eleni; Oikonomou, Eleni; Palli, Domenico; Grioni, Sara; Vineis, Paolo; Tumino, Rosaria; Panico, Salvatore; Peeters, Petra H M; Weiderpass, Elisabete; Engeset, Dagrun; Braaten, Tonje; Dorronsoro, Miren; Chirlaque, María-Dolores; Sánchez, María-José; Barricarte, Aurelio; Zamora-Ros, Raul; Argüelles, Marcial; Jirström, Karin; Wallström, Peter; Nilsson, Lena M; Ljuslinder, Ingrid; Travis, Ruth C; Khaw, Kay-Tee; Wareham, Nick; Freisling, Heinz; Licaj, Idlir; Jenab, Mazda; Gunter, Marc J; Murphy, Neil; Romaguera-Bosch, Dora; Riboli, Elio

    2014-07-15

    Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992-2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. After a median follow-up of 11.6 years, 4,234 participants developed CRC (mean age 64.7 ± 8.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95-1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97-1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84-1.11) and tea (HR 0.97, 95% CI 0.86-1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC.

  1. A functional programming interpreter. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Robison, Arch Douglas

    1987-01-01

    Functional Programming (FP) sup BAC87 is an alternative to conventional imperative programming languages. This thesis describes an FP interpreter implementation. Superficially, FP appears to be a simple, but very inefficient language. Its simplicity, however, allows it to be interpreted quickly. Much of the inefficiency can be removed by simple interpreter techniques. This thesis describes the Illinois Functional Programming (IFP) interpreter, an interactive functional programming implementation which runs under both MS-DOS and UNIX. The IFP interpreter allows functions to be created, executed, and debugged in an environment very similar to UNIX. IFP's speed is competitive with other interpreted languages such as BASIC.

  2. Deterring weapons of mass destruction terrorism. Master`s thesis

    SciTech Connect

    LeHardy, F.A.

    1997-12-01

    This thesis examines terrorist acts involving the use of weapons of mass destruction (WMD) against unsuspecting civilians by the Aum Shinrikyo and Rajneesh cults. The proliferation of WMD (i.e., nuclear, chemical, and biological weapons) has created a concern that terrorists might use WMD. Despite obvious signs, these groups were not identified as terrorists until after they committed terrorist attacks. This thesis identifies common characteristics of terrorists that have used WMD in the past and generates indicators of non-state actors that might commit WMD terrorism in the future.

  3. Interdisziplinärer Arbeitskreis Bewegungsstörungen (IAB): an interdisciplinary working group for promoting multimodal therapy of movement disorders.

    PubMed

    Adib Saberi, Fereshte; Dressler, Dirk

    2013-04-01

    Increasing complexity of therapeutic strategies for movement disorders (MD) requires multimodal therapies involving various health care professionals and physicians. Coordinating all professions involved is difficult. An interdisciplinary working group (Interdisziplinärer Arbeitskreis Bewegungsstörungen, IAB) serves to promote and improve multimodal therapies of MD. IAB was started 6 years ago in Hamburg, Germany as an interdisciplinary special interest group with about 25 physiotherapists, occupational therapists, speech therapists, nurse specialists, physicians and invited guests regularly meeting each quarter. IAB expanded and now also includes a webpage with data bases, a special interest group for Parkinson assistants, a meeting arm for organising meetings accredited by continuous medical education authorities and a publication arm for production of educational materials including a communication form and a communication calendar developed by IAB. Recently, IAB acquired a video production enterprise producing educational MD videos. In the meantime, two more IAB groups were founded in other regions of Germany. IAB's stability over more than 6 years and its expansion into more regions and other tasks documents the demand for promotion of multimodal therapies for MD.

  4. Production of ⁶¹Cu by the natZn(p,α) reaction: Improved separation and specific activity determination by titration with three chelators

    SciTech Connect

    Asad, Ali H.; Smith, Suzanne V.; Morandeau, Laurence M.; Chan, Sun; Jeffery, Charmaine M.; Price, Roger I.

    2015-09-01

    In this study, the cyclotron-based production of position-emitting ⁶¹Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched ⁶⁴Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate ⁶¹Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified ⁶¹Cu determined using ICP-MS analysis ranged from 143.3±14.3(SD) to 506.2±50.6 MBq/μg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7±0.2 to 412.5±15.3 MBq/μg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.

  5. Production of ⁶¹Cu by the natZn(p,α) reaction: Improved separation and specific activity determination by titration with three chelators

    DOE PAGES

    Asad, Ali H.; Smith, Suzanne V.; Morandeau, Laurence M.; ...

    2015-09-01

    In this study, the cyclotron-based production of position-emitting ⁶¹Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched ⁶⁴Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate ⁶¹Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified ⁶¹Cu determined using ICP-MS analysis ranged from 143.3±14.3(SD) to 506.2±50.6 MBq/μg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7±0.2 to 412.5±15.3 MBq/μg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods aremore » significantly affected by the presence of trace-metal contaminants.« less

  6. Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes.

    PubMed

    Thier, Ricarda; Brüning, Thomas; Roos, Peter H; Rihs, Hans-Peter; Golka, Klaus; Ko, Yon; Bolt, Hermann M

    2003-06-01

    Inherited genetic traits co-determine the susceptibility of an individual to a toxic chemical. Special emphasis has been put on individual responses to environmental and industrial carcinogens, but other chronic diseases are of increasing interest. Polymorphisms of relevant xenobiotic metabolising enzymes may be used as toxicological susceptibility markers. A growing number of genes encoding enzymes involved in biotransformation of toxicants and in cellular defence against toxicant-induced damage to the cells has been identified and cloned, leading to increased knowledge of allelic variants of genes and genetic defects that may result in a differential susceptibility toward environmental toxicants. "Low penetrating" polymorphisms in metabolism genes tend to be much more common in the population than allelic variants of "high penetrating" cancer genes, and are therefore of considerable importance from a public health point of view. Positive associations between cancer and CYP1A1 alleles, in particular the *2C I462V allele, were found for tissues following the aerodigestive tract. Again, in most cases, the effect of the variant CYP1A1 allele becomes apparent or clearer in connection with the GSTM1 null allele. The CYP1B1 codon 432 polymorphism (CYP1B1*3) has been identified as a susceptibility factor in smoking-related head-and-neck squameous cell cancer. The impact of this polymorphic variant of CYP1B1 on cancer risk was also reflected by an association with the frequency of somatic mutations of the p53 gene. Combined genotype analysis of CYP1B1 and the glutathione transferases GSTM1 or GSTT1 has also pointed to interactive effects. Of particular interest for the industrial and environmental field is the isozyme CYP2E1. Several genotypes of this isozyme have been characterised which seem to be associated with different levels of expression of enzyme activity. The acetylator status for NAT2 can be determined by genotyping or by phenotyping. In the pathogenesis of

  7. The Status of the Non-discursiveness Thesis.

    ERIC Educational Resources Information Center

    Willard, Charles Arthur

    1981-01-01

    Argues that the nondiscursiveness thesis introduces more breadth into argumentation than do any of the present alternative points of view. Maintains that all communication modalites are called into play by ordinary arguers and that the meanings of statements oftentimes cannot be understood unless attributions are made. (PD)

  8. Thesis Writing Challenges for Non-Native MA Students

    ERIC Educational Resources Information Center

    Sadeghi, Karim; Shirzad Khajepasha, Arash

    2015-01-01

    Writing in a second (L2)/foreign language is generally a challenging activity, and writing an MA thesis, as an example of academic enterprise, can be daunting when done in a language in which the writer is not fully competent. The challenge such a genre of writing poses for L2 writers has not been properly addressed. To fill in the gap in this…

  9. Social Indicators of Education and the Model Minority Thesis.

    ERIC Educational Resources Information Center

    Macaranas, Federico M.

    The idea that Asian Americans constitute a "model minority" needing no special help with education or employment is quite widespread, even amongst government officials. This "model minority" thesis has not been investigated empirically, in part because of the lack of a theoretical construct. An interdisciplinary model focusing…

  10. Adaptive Research Supervision: Exploring Expert Thesis Supervisors' Practical Knowledge

    ERIC Educational Resources Information Center

    de Kleijn, Renske A. M.; Meijer, Paulien C.; Brekelmans, Mieke; Pilot, Albert

    2015-01-01

    Several researchers have suggested the importance of being responsive to students' needs in research supervision. Adapting support strategies to students' needs in light of the goals of a task is referred to as "adaptivity." In the present study, the practice of adaptivity is explored by interviewing expert thesis supervisors about…

  11. The Jailing of America's Homeless: Evaluating the Rabble Management Thesis

    ERIC Educational Resources Information Center

    Fitzpatrick, Kevin M.; Myrstol, Brad

    2011-01-01

    The authors of this article test hypotheses derived from Irwin's rabble management thesis. The analysis uses data from 47,592 interviews conducted with jailed adults in 30 U.S. cities as part of the Arrestee Drug Abuse Monitoring program. Clearly, homeless persons are overrepresented among those arrested and booked into local jails. Bivariate…

  12. A Path Model for Students' Attitudes to Writing a Thesis.

    ERIC Educational Resources Information Center

    Sachs, John

    2002-01-01

    Using responses of 90 undergraduate and graduate students, developed a model in which action-control belief variables have only an indirect effect on students' attitudes to writing a thesis mediated through two academic orientation variables. The model accounted for a large proportion of the repeatable variance in the two academic orientation…

  13. Problem Definition and Thesis Writing. Workshops for the Postgraduate Student.

    ERIC Educational Resources Information Center

    Zuber-Skerritt, Ortrun; Knight, Nick

    1986-01-01

    Some innovative solutions to two key graduate research problems, definition of the research problem and planning and writing the thesis first draft, are outlined. Workshops are recommended as an effective format for assisting students in developing research skills through practical guidance, group support, and discussion. (MSE)

  14. A Supervisor's Roles for Successful Thesis and Dissertation

    ERIC Educational Resources Information Center

    Mhunpiew, Nathara

    2013-01-01

    The success of a thesis or a dissertation for a graduate student relies upon the roles of their supervisor. The student not only needs to be equipped with the knowledge, but also be able to manage others and external factors at the same time. The journey during the period of conducting research is mixed with various tasks. Five supportive roles of…

  15. Intergroup Contact and Ingroup Reappraisal: Examining the Deprovincialization Thesis

    ERIC Educational Resources Information Center

    Verkuyten, Maykel; Thijs, Jochem; Bekhuis, Hidde

    2010-01-01

    According to the deprovincialization thesis, interethnic contact involves a reappraisal and distancing from the ingroup. Contact can broaden one's horizon by acknowledging and recognizing the value of other cultures and thereby putting the taken-for-granted own cultural standards into perspective. The current research uses data from three surveys…

  16. Motivation in medical students: a PhD thesis report.

    PubMed

    Kusurkar, Rashmi

    2012-08-01

    The aims of this thesis were to gather insights and investigate the factors influencing, outcomes and applications of medical students' motivation. This thesis consists of three literature reviews, four research papers and two application papers. Two research studies investigated the relationships of student motivation with study strategy, effort and academic performance through structural equation modelling and cluster analysis. The relationships of age, maturity, gender and educational background with motivation were investigated through multiple regression analysis. The results of this thesis were 1. Developments in medical education appear to have undervalued student motivation. 2. Motivation is an independent variable in medical education; intrinsic motivation is significantly associated with deep study strategy, high study effort and good academic performance. 3. Motivation is a dependent variable in medical education and is significantly affected by age, maturity, gender, educational background; intrinsic motivation is enhanced by providing students with autonomy, feedback and emotional support. 4. Strength of motivation for medical school can be reliably measured by Strength of Motivation for Medical School questionnaire. The conclusion of this thesis was that it is important to give consideration to motivation in medical education because intrinsic motivation leads to better learning and performance and it can be enhanced through giving students autonomy in learning, feedback about competence and emotional support.

  17. Turning Points: Improving Honors Student Preparation for Thesis Completion

    ERIC Educational Resources Information Center

    Patino, Cynthia

    2012-01-01

    This dissertation is an action research study that had as its primary goal to increase retention of honors college students at Arizona State University by implementing an additional advising session during the fifth semester of their academic career. Introducing additional, strategically-timed support for the honors thesis and demystifying the…

  18. Master's Thesis Projects: Student Perceptions of Supervisor Feedback

    ERIC Educational Resources Information Center

    de Kleijn, Renske A. M.; Mainhard, M. Tim; Meijer, Paulien C.; Brekelmans, Mieke; Pilot, Albert

    2013-01-01

    A growing body of research has investigated student perceptions of written feedback in higher education coursework, but few studies have considered feedback perceptions in one-on-one and face-to-face contexts such as master's thesis projects. In this article, student perceptions of feedback are explored in the context of the supervision of…

  19. Assessing the Doctoral Thesis When It Includes Published Work

    ERIC Educational Resources Information Center

    Sharmini, Sharon; Spronken-Smith, Rachel; Golding, Clinton; Harland, Tony

    2015-01-01

    In this article we explore how examiners assess a thesis that includes published work. An online survey was used to gather data on approaches to assessing publication-based theses (PBTs). The respondents were 62 supervisors who had experience examining PBTs across a range of disciplines at a research-intensive university in New Zealand. Nearly…

  20. Seminar for Master's Thesis Projects: Promoting Students' Self-Regulation

    ERIC Educational Resources Information Center

    Miedijensky, Shirley; Lichtinger, Einat

    2016-01-01

    This study presents a thesis seminar model aimed at promoting students' self-regulation. Students' perceptions regarding the contribution of the seminar to their learning process were characterized and the seminar's effect upon their self-regulation expressions was examined. Data was collected using questionnaires and analyzed thematically. The…

  1. Complete Your Dissertation or Thesis in Two Semesters or Less

    ERIC Educational Resources Information Center

    Ogden, Evelyn Hunt

    2006-01-01

    This newly updated guide describes how to effectively and efficiently manage the dissertation or thesis process in two semesters or less. Written for doctoral and master's degree students enrolled in on-campus programs and students pursuing accelerated and online-based degree programs, this book demystifies the seemingly daunting process. From…

  2. Support for Different Roles in Software Engineering Master's Thesis Projects

    ERIC Educational Resources Information Center

    Host, M.; Feldt, R.; Luders, F.

    2010-01-01

    Like many engineering programs in Europe, the final part of most Swedish software engineering programs is a longer project in which the students write a Master's thesis. These projects are often conducted in cooperation between a university and industry, and the students often have two supervisors, one at the university and one in industry. In…

  3. The Thesis Black Market: Present State and Background

    ERIC Educational Resources Information Center

    Gang, Wang

    2007-01-01

    The superficial reason for the existence of the thesis black market is the glut of theses and the shortage of publishing space; behind that is the skewed academic assessment system. Today, the following circumstances can be found in virtually all institutions of higher education in China: (1) A master's degree student must, during the two or…

  4. Combined MIPAS (airborne/satellite), CALIPSO and in situ study on large potential NAT particles observed in early Arctic winter stratosphere in December 2011

    NASA Astrophysics Data System (ADS)

    Woiwode, Wolfgang; Höpfner, Michael; Pitts, Michael; Poole, Lamont; Oelhaf, Hermann; Molleker, Sergej; Borrmann, Stephan; Ebersoldt, Andreas; Frey, Wiebke; Gulde, Thomas; Maucher, Guido; Piesch, Christof; Sartorius, Christian; Orphal, Johannes

    2015-04-01

    The understanding of the characteristics of large HNO3-containing particles (potential 'NAT-rocks') involved in vertical redistribution of HNO3 in the polar winter stratosphere is limited due to the difficult accessibility of these particles by observations. While robust polar stratospheric cloud (PSC) classification schemes exist for observations by the space-borne lidar aboard CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations) as well as for the passive mid-infrared limb observations by MIPAS (Michelson Interferometer for Passive Atmospheric Sounding), these observations are hardly exploited for the detection of large (diameter >10 μm) NAT particles. This is due to the facts that these particles have low overall number densities, resulting in weak detectable signatures, and that the physical characteristics of these particles (i.e. shape, morphology, HNO3-content and optical characteristics) are uncertain. We investigate collocated and complementary observations of a low-density potential large NAT particle field by the space-borne instruments CALIPSO and MIPAS-ENVISAT as well as the airborne observations by the limb-sounder MIPAS-STR and the in situ particle probe FSSP-100 (Forward Scattering Spectrometer Probe 100) aboard the high-altitude aircraft Geophysica. The observations aboard the Geophysica on 11 December 2011 associated to ESSenCe (ESa Sounder Campaign 2011) provided us the unique opportunity to study in detail the lower boundary region of a PSC where large potential NAT particles (>20 μm in diameter) were detected in situ. We analyse the ambient temperatures and gas-phase composition (HNO3 and H2O), the signatures of the observed particles in the CALIPSO and MIPAS observations, the HNO3-content of these particles suggested by the FSSP-100 and MIPAS-STR observations, and focus on the spectral fingerprint of these particles in the MIPAS-STR observations. While the spectral characterisation of the observed particles is subject

  5. ERBE S7 NAT

    Atmospheric Science Data Center

    2016-06-15

    ... Level:  L2 Platform:  ERBS, NOAA-9 & 10 Instrument:  NonScanner Spatial Coverage:  ... The measurements are continuous over the entire globe for NOAA-9 and NOAA-10, and between 57 degrees north and south latitudes for ERBS ...

  6. ERBE S8 NAT

    Atmospheric Science Data Center

    2016-06-15

    ... Level:  L2 Platform:  ERBS, NOAA 9 & 10 Instrument:  Scanner, NonScanner Spatial ... The measurements are continuous over the entire globe for NOAA-9 and NOAA-10, and between 57 degrees north and south latitudes for ERBS ...

  7. Publishing a master's thesis: a guide for novice authors.

    PubMed

    Resta, Robert G; McCarthy Veach, Patricia; Charles, Sarah; Vogel, Kristen; Blase, Terri; Palmer, Christina G S

    2010-06-01

    Publication of original research, clinical experiences, and critical reviews of literature are vital to the growth of the genetic counseling field, delivery of genetic counseling services, and professional development of genetic counselors. Busy clinical schedules, lack of time and funding, and training that emphasizes clinical skills over research skills may make it difficult for new genetic counselors to turn their thesis projects into publications. This paper summarizes and elaborates upon a presentation aimed at de-mystifying the publishing process given at the 2008 National Society of Genetic Counselors Annual Education Conference. Specific topics include familiarizing prospective authors, particularly genetic counseling students, with the basics of the publication process and related ethical considerations. Former students' experiences with publishing master's theses also are described in hopes of encouraging new genetic counselors to submit for publication papers based on their thesis projects.

  8. [A 100 year old thesis. Amanuensis Hans Christian Geelmuyden].

    PubMed

    Bremer, J

    1997-12-10

    Hans Christian Geelmuyden (1861-1945) was amanuensis (assistant professor) at the Institute of Physiology, University of Oslo from 1889 to 1931. In 1897 he was awarded the degree "Doctor of Medicine" for his thesis "Om aceton som stofvexelprodukt" (On acetone as a metabolic product). The Nobel laureate Feodor Lynen referred to this thesis, which was also published in German, stating that Geelmuyden was the first to establish that ketone bodies are formed from fatty acids. Geelmuyden also established that acetone is metabolized in rabbits and dogs. Geelmuyden was a prolific writer on fat metabolism and diabetes and wrote a series of extensive reviews on these topics in Ergebnisse der Physiologie. Geelmuyden was active in the treatment of diabetic patients.

  9. Practical issues in 'writing up' a research thesis.

    PubMed

    Roberts, P

    2000-07-01

    Beginning to 'write up' your research thesis can seem a daunting prospect. While the experience can be stressful, with careful planning, the process can be managed effectively, and prove both rewarding and pleasurable. Paula Roberts offers a practical guide to managing the process of writing-up. Three distinct phases are discussed: the input phase of planning the write-up; the process phase of writing-up; and the output phase ofpreparing the finished document for submission.

  10. An Examination of the Neural Unreliability Thesis of Autism.

    PubMed

    Butler, John S; Molholm, Sophie; Andrade, Gizely N; Foxe, John J

    2016-12-06

    An emerging neuropathological theory of Autism, referred to here as "the neural unreliability thesis," proposes greater variability in moment-to-moment cortical representation of environmental events, such that the system shows general instability in its impulse response function. Leading evidence for this thesis derives from functional neuroimaging, a methodology ill-suited for detailed assessment of sensory transmission dynamics occurring at the millisecond scale. Electrophysiological assessments of this thesis, however, are sparse and unconvincing. We conducted detailed examination of visual and somatosensory evoked activity using high-density electrical mapping in individuals with autism (N = 20) and precisely matched neurotypical controls (N = 20), recording large numbers of trials that allowed for exhaustive time-frequency analyses at the single-trial level. Measures of intertrial coherence and event-related spectral perturbation revealed no convincing evidence for an unreliability account of sensory responsivity in autism. Indeed, results point to robust, highly reproducible response functions marked for their exceedingly close correspondence to those in neurotypical controls.

  11. Establishment of the 1st World Health Organization International Standard for Plasmodium falciparum DNA for nucleic acid amplification technique (NAT)-based assays

    PubMed Central

    Padley, David J; Heath, Alan B; Sutherland, Colin; Chiodini, Peter L; Baylis, Sally A

    2008-01-01

    Background In order to harmonize results for the detection and quantification of Plasmodium falciparum DNA by nucleic acid amplification technique (NAT)-based assays, a World Health Organization (WHO) collaborative study was performed, evaluating a series of candidate standard preparations. Methods Fourteen laboratories from 10 different countries participated in the collaborative study. Four candidate preparations based upon blood samples parasitaemic for P. falciparum were evaluated in the study. Sample AA was lyophilized, whilst samples BB, CC and DD were liquid/frozen preparations. The candidate standards were tested by each laboratory at a range of dilutions in four independent assays, using both qualitative and quantitative NAT-based assays. The results were collated and analysed statistically. Results Twenty sets of data were returned from the participating laboratories and used to determine the mean P. falciparum DNA content for each sample. The mean log10 "equivalents"/ml were 8.51 for sample AA, 8.45 for sample BB, 8.35 for sample CC, and 5.51 for sample DD. The freeze-dried preparation AA, was examined by accelerated thermal degradation studies and found to be highly stable. Conclusion On the basis of the collaborative study, the freeze-dried material, AA (NIBSC code No. 04/176) was established as the 1st WHO International Standard for P. falciparum DNA NAT-based assays and has been assigned a potency of 109 International Units (IU) per ml. Each vial contains 5 × 108 IU, equivalent to 0.5 ml of material after reconstitution. PMID:18652656

  12. Thermochemical Kinetics of H2O and HNO3 on crystalline Nitric Acid Hydrates (alpha-, beta-NAT, NAD) in the range 175-200 K

    NASA Astrophysics Data System (ADS)

    Rossi, Michel J.; Iannarelli, Riccardo

    2015-04-01

    The growth of NAT (Nitric Acid Trihydrate, HNO3x3H2O) and NAD (Nitric Acid Dihydrate, HNO3x2H2O) on an ice substrate, the evaporative lifetime of NAT and NAD as well as the interconversion of alpha- and beta-NAT competing with evaporation and growth under UT/LS conditions depends on the interfacial kinetics of H2O and HNO3 vapor on the condensed phase. Despite the existence of some literature results we have embarked on a systematic investigation of the kinetics using a multidiagnostic experimental approach enabled by the simultaneous observation of both the gas (residual gas mass spectrometry) as well as the condensed phase (FTIR absorption in transmission). We report on thermochemically consistent mass accommodation coefficients alpha and absolute evaporation rates Rev/molecule s-1cm-3 as a function of temperature which yields the corresponding vapor pressures of both H2O and HNO3 in equilibrium with the crystalline phases, hence the term thermochemical kinetics. These results have been obtained using a stirred flow reactor (SFR) using a macroscopic pure ice film of 1 micron or so thickness as a starting substrate mimicking atmospheric ice particles and are reported in a phase diagram specifically addressing UT (Upper Troposphere)/LS (Lower Stratosphere) conditions as far as temperature and partial pressures are concerned. The experiments have been performed either at steady-state flow conditions or in transient supersaturation using a pulsed solenoid valve in order to generate gas pulses whose decay were subsequently monitored in real time. Special attention has been given to the effect of the stainless-steel vessel walls in that Langmuir adsorption isotherms for H2O and HNO3 have been used to correct for wall-adsorption of both probe gases. Typically, the accommodation coefficients of H2O and HNO3 are similar throughout the temperature range whereas the rates of evaporation Rev of H2O are significantly larger than for HNO3 thus leading to the difference in

  13. Affinity of nat/68Ga-Labelled Curcumin and Curcuminoid Complexes for β-Amyloid Plaques: Towards the Development of New Metal-Curcumin Based Radiotracers

    PubMed Central

    Rubagotti, Sara; Croci, Stefania; Ferrari, Erika; Iori, Michele; Capponi, Pier C.; Lorenzini, Luca; Calzà, Laura; Versari, Annibale; Asti, Mattia

    2016-01-01

    Curcumin derivatives labelled with fluorine-18 or technetium-99m have recently shown their potential as diagnostic tools for Alzheimer’s disease. Nevertheless, no study by exploiting the labelling with gallium-68 has been performed so far, in spite of its suitable properties (positron emitter, generator produced radionuclide). Herein, an evaluation of the affinity for synthetic β-amyloid fibrils and for amyloid plaques of three nat/68Ga-labelled curcumin analogues, namely curcumin curcumin (CUR), bis-dehydroxy-curcumin (bDHC) and diacetyl-curcumin (DAC), was performed. Affinity and specificity were tested in vitro on amyloid synthetic fibrils by using gallium-68 labelled compounds. Post-mortem brain cryosections from Tg2576 mice were used for the ex vivo visualization of amyloid plaques. The affinity of 68Ga(CUR)2+, 68Ga(DAC)2+, and 68Ga(bDHC)2+ for synthetic β-amyloid fibrils was moderate and their uptake could be observed in vitro. On the other hand, amyloid plaques could not be visualized on brain sections of Tg2576 mice after injection, probably due to the low stability of the complexes in vivo and of a hampered passage through the blood–brain barrier. Like curcumin, all nat/68Ga-curcuminoid complexes maintain a high affinity for β-amyloid plaques. However, structural modifications are still needed to improve their applicability as radiotracers in vivo. PMID:27608011

  14. Depth profile of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions

    NASA Astrophysics Data System (ADS)

    Mokhtari Oranj, Leila; Jung, Nam-Suk; Kim, Dong-Hyun; Lee, Arim; Bae, Oryun; Lee, Hee-Seock

    2016-11-01

    Experimental and simulation studies on the depth profiles of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions were carried out. Irradiation experiments were performed at the high-intensity proton linac facility (KOMAC) in Korea. The targets, irradiated by 100-MeV protons, were arranged in a stack consisting of natural Pb, Al, Au foils and Pb plates. The proton beam intensity was determined by activation analysis method using 27Al(p, 3p1n)24Na, 197Au(p, p1n)196Au, and 197Au(p, p3n)194Au monitor reactions and also by Gafchromic film dosimetry method. The yields of produced radio-nuclei in the natPb activation foils and monitor foils were measured by HPGe spectroscopy system. Monte Carlo simulations were performed by FLUKA, PHITS/DCHAIN-SP, and MCNPX/FISPACT codes and the calculated data were compared with the experimental results. A satisfactory agreement was observed between the present experimental data and the simulations.

  15. Collaborative study report: evaluation of the ATCC experimental mycoplasma reference strains panel prepared for comparison of NAT-based and conventional mycoplasma detection methods.

    PubMed

    Dabrazhynetskaya, Alena; Volokhov, Dmitriy V; Lin, Tsai-Lien; Beck, Brian; Gupta, Rajesh K; Chizhikov, Vladimir

    2013-11-01

    The main goal of this collaborative study was to evaluate the experimental panel of cryopreserved mycoplasma reference strains recently prepared by the American Type Culture Collection (ATCC(®)) in order to assess the viability and dispersion of cells in the mycoplasma stocks by measuring the ratio between the number of genomic copies (GC) and the number of colony forming units (CFU) in the reference preparations. The employment of microbial reference cultures with low GC/CFU ratios is critical for unbiased and reliable comparison of mycoplasma testing methods based on different methodological approaches, i.e., Nucleic Acid Testing (NAT) and compendial culture-based techniques. The experimental panel included ten different mycoplasma species known to represent potential human and animal pathogens as well as common contaminants of mammalian and avian cell substrates used in research, development, and manufacture of biological products. Fifteen laboratories with expertise in field of mycoplasma titration and quantification of mycoplasmal genomic DNA participated in the study conducted from February to October of 2012. The results of this study demonstrated the feasibility of preparing highly viable and dispersed (possessing low GC/CFU ratios) frozen stocks of mycoplasma reference materials, required for reliable comparison of NAT-based and conventional mycoplasma detection methods.

  16. Affinity of (nat/68)Ga-Labelled Curcumin and Curcuminoid Complexes for β-Amyloid Plaques: Towards the Development of New Metal-Curcumin Based Radiotracers.

    PubMed

    Rubagotti, Sara; Croci, Stefania; Ferrari, Erika; Iori, Michele; Capponi, Pier C; Lorenzini, Luca; Calzà, Laura; Versari, Annibale; Asti, Mattia

    2016-09-06

    Curcumin derivatives labelled with fluorine-18 or technetium-99m have recently shown their potential as diagnostic tools for Alzheimer's disease. Nevertheless, no study by exploiting the labelling with gallium-68 has been performed so far, in spite of its suitable properties (positron emitter, generator produced radionuclide). Herein, an evaluation of the affinity for synthetic β-amyloid fibrils and for amyloid plaques of three (nat/68)Ga-labelled curcumin analogues, namely curcumin curcumin (CUR), bis-dehydroxy-curcumin (bDHC) and diacetyl-curcumin (DAC), was performed. Affinity and specificity were tested in vitro on amyloid synthetic fibrils by using gallium-68 labelled compounds. Post-mortem brain cryosections from Tg2576 mice were used for the ex vivo visualization of amyloid plaques. The affinity of (68)Ga(CUR)₂⁺, (68)Ga(DAC)₂⁺, and (68)Ga(bDHC)₂⁺ for synthetic β-amyloid fibrils was moderate and their uptake could be observed in vitro. On the other hand, amyloid plaques could not be visualized on brain sections of Tg2576 mice after injection, probably due to the low stability of the complexes in vivo and of a hampered passage through the blood-brain barrier. Like curcumin, all (nat/68)Ga-curcuminoid complexes maintain a high affinity for β-amyloid plaques. However, structural modifications are still needed to improve their applicability as radiotracers in vivo.

  17. Collaborative study for the establishment of the Ph. Eur. Hepatitis E virus RNA for NAT testing biological reference preparation batch 1.

    PubMed

    Baylis, S A; Terao, E; Blümel, J; Hanschmann, K-M O

    2017-01-01

    A new European Pharmacopoeia (Ph. Eur.) biological reference preparation (BRP) had to be established further to the decision to include nucleic acid testing (NAT) for the detection of hepatitis E virus (HEV) RNA in the monograph Human plasma (pooled and treated for virus inactivation) (1646). To this purpose, an international collaborative study was launched in the framework of the Biological Standardisation Programme (BSP) of the European Directorate for the Quality of Medicines & HealthCare (EDQM) and the Commission of the European Union (EU). The study was run in conjunction with the establishment of the 1(st) World Health Organization (WHO) international reference panel (IRP) for hepatitis E virus RNA genotypes (8578/13). Twenty-three laboratories used in-house developed and commercially available assays to calibrate a lyophilised candidate BRP prepared from a HEV 3f strain positive human plasma against the 1(st) WHO International Standard (IS) for HEV RNA (6329/10). Results from quantitative and qualitative assays were in good agreement and were combined to calculate an assigned potency. Real-time stability studies indicated that the candidate BRP is very stable at lower temperatures and is thus suitable for long-term use. Based on these results, in February 2016, the Ph. Eur. Commission adopted the candidate material as the hepatitis E virus RNA for NAT testing BRP batch 1, with an assigned unitage of 2.1 × 10(4) IU/vial (4.32 log10 IU/vial).

  18. Measurement of natW(p,xn)177,178,179Re excitation function of natural tungsten by using a 100-MeV proton beam

    NASA Astrophysics Data System (ADS)

    Yoon, Jungran; Lee, Jieun; Lee, Samyol

    2017-01-01

    Measurements of the proton-induced excitation function for the natW(p,xn)177,178,179Re nuclear reaction has been measured in the energy region below 100 MeV by using the 100-MeV proton linear accelerator at the Korea Multi-Purpose Accelerator Complex. The stacked foil activation technique was adopted in the present study. The gamma-rays generated from the proton-irradiated samples were measured by using a gamma-ray spectroscopy system with a HPGe detector. The 27Al(p,3p+n)24Na reaction was used as a monitor reaction for proton flux monitoring. The nuclear reactions of natW(p,xn)177,178,179Re were observed in the present study. The proton-induced excitation functions of natural tungsten were derived from the delayed gamma-ray yield of the produced nucleus. The present results were compared with the previous experimental excitation function data of Yu. E. Titarenko et al. [1].

  19. Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women.

    PubMed

    Zgheib, Nathalie K; Shamseddine, Ashraf A; Geryess, Eddy; Tfayli, Arafat; Bazarbachi, Ali; Salem, Ziad; Shamseddine, Ali; Taher, Ali; El-Saghir, Nagi S

    2013-01-01

    Changes in the activity of drug metabolizing enzymes (DMEs) are potentially associated with cancer risk. This relationship is attributed to their involvement in the bioactivation of multiple procarcinogens or the metabolism of multiple substrates including an array of xenobiotics and environmental carcinogens. 326 Lebanese women of whom 99 were cancer free (controls) and 227 were diagnosed with breast cancer (cases) were included. Blood for DNA was collected and medical charts were reviewed. Three genotyping methods were employed including: (1) restriction fragment length polymorphism (RFLP) for CYP2E1*5B, CYP2E1*6, NAT2*5 and NAT2*6; (2) gel electrophoresis for GSTM1 and GSTT1; and (3) real-time PCR for GSTP1 Ile/Val polymorphism. We analyzed the relationship between genetic susceptibilities in selected xenobiotic metabolizing genes and breast cancer risk. Allele frequencies were fairly similar to previously reported values from neighboring populations with relevant migration routes. There were no statistically significant differences in the distribution of variant carcinogen metabolizing genes between cases and controls even after adjusting for age at diagnosis, menopausal status, smoking, and alcohol intake. Despite its limitations, this is the first study that assesses the role of genetic polymorphisms in DMEs with breast cancer in a sample of Lebanese women. Further studies are needed to determine the genetic predisposition and gene-environment interactions of breast cancer in this population.

  20. The M68HC11 gripper controller software. Thesis

    NASA Technical Reports Server (NTRS)

    Tsai, Jodi Wei-Duk

    1991-01-01

    This thesis discusses the development of firmware for the 68HC11 gripper controller. A general description of the software and hardware interfaces is given. The C library interface for the gripper is then described and followed by a detailed discussion of the software architecture of the firmware. A procedure to assemble and download 68HC11 programs is presented in the form of a tutorial. The tools used to implement this environment are then described. Finally, the implementation of the configuration management scheme used to manage all CIRSSE software is presented.

  1. A Petri net controller for distributed hierarchical systems. Thesis

    NASA Technical Reports Server (NTRS)

    Peck, Joseph E.

    1991-01-01

    The solutions to a wide variety of problems are often best organized as a distributed hierarchical system. These systems can be graphically and mathematically modeled through the use of Petri nets, which can easily represent synchronous, asynchronous, and concurrent operations. This thesis presents a controller implementation based on Petri nets and a design methodology for the interconnection of distributed Petri nets. Two case studies are presented in which the controller operates a physical system, the Center for Intelligent Robotic Systems for Space Exploration Dual Arm Robotic Testbed.

  2. The Thesis of Philosophy and Its Place in Educational Research and Practice.

    ERIC Educational Resources Information Center

    Fisher, William P., Jr.

    The potentials and problems presented by the thesis of philosophy and their relationship to educational research and practice are discussed. The question of whether philosophy can have a unique thesis is examined. It is suggested that the thesis of philosophy asserts the creation of meaning as an ongoing project that must be constantly monitored.…

  3. Electronic Thesis Initiative: Pilot Project of McGill University, Montreal

    ERIC Educational Resources Information Center

    Park, Eun G.; Zou, Qing; McKnight, David

    2007-01-01

    Purpose: To set up a protocol for electronic thesis and dissertation (ETD) submission for the electronic thesis initiative pilot project at McGill University in Montreal, Canada. Design/methodology/approach: An electronic thesis and dissertation submission protocol was implemented and tested. To test authoring tools, we had 50 students submit…

  4. TCP Packet Trace Analysis. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Shepard, Timothy J.

    1991-01-01

    Examination of a trace of packets collected from the network is often the only method available for diagnosing protocol performance problems in computer networks. This thesis explores the use of packet traces to diagnose performance problems of the transport protocol TCP. Unfortunately, manual examination of these traces can be so tedious that effective analysis is not possible. The primary contribution of this thesis is a graphical method of displaying the packet trace which greatly reduce, the tediousness of examining a packet trace. The graphical method is demonstrated by the examination of some packet traces of typical TCP connections. The performance of two different implementations of TCP sending data across a particular network path is compared. Traces many thousands of packets long are used to demonstrate how effectively the graphical method simplifies examination of long complicated traces. In the comparison of the two TCP implementations, the burstiness of the TCP transmitter appeared to be related to the achieved throughput. A method of quantifying this burstiness is presented and its possible relevance to understanding the performance of TCP is discussed.

  5. Criticality Safety Analysis on the Mixed Be, Nat-U, and C (Graphite) Reflectors in 55-Gallon Waste Drums and Their Equivalents for HWM Applications

    SciTech Connect

    Chou, P

    2011-12-14

    The objective of this analysis is to develop and establish the technical basis on the criticality safety controls for the storage of mixed beryllium (Be), natural uranium (Nat-U), and carbon (C)/graphite reflectors in 55-gallon waste containers and/or their equivalents in Hazardous Waste Management (HWM) facilities. Based on the criticality safety limits and controls outlined in Section 3.0, the operations involving the use of mixed-reflector drums satisfy the double-contingency principle as required by DOE Order 420.1 and are therefore criticality safe. The mixed-reflector mass limit is 120 grams for each 55-gallon drum or its equivalent. a reflector waiver of 50 grams is allowed for Be, Nat-U, or C/graphite combined. The waived reflectors may be excluded from the reflector mass calculations when determining if a drum is compliant. The mixed-reflector drums are allowed to mix with the typical 55-gallon one-reflector drums with a Pu mass limit of 120 grams. The fissile mass limit for the mixed-reflector container is 65 grams of Pu equivalent each. The corresponding reflector mass limits are 300 grams of Be, and/or 100 kilograms of Nat-U, and/or 110 kilograms of C/graphite for each container. All other unaffected control parameters for the one-reflector containers remain in effect for the mixed-reflector drums. For instance, Superior moderators, such as TrimSol, Superla white mineral oil No. 9, paraffin, and polyethylene, are allowed in unlimited quantities. Hydrogenous materials with a hydrogen density greater than 0.133 gram/cc are not allowed. Also, an isolation separation of no less than 76.2 cm (30-inch) is required between a mixed array and any other array. Waste containers in the action of being transported are exempted from this 76.2-cm (30-inch) separation requirement. All deviations from the CS controls and mass limits listed in Section 3.0 will require individual criticality safety analyses on a case-by-case basis for each of them to confirm their

  6. Writing your thesis Paul Oliver Writing your thesis Publisher: Sage No. of pages: 208 £16.99 0761942998 0761942998 [Formula: see text].

    PubMed

    2004-10-01

    So you need to write a thesis and want some succinct, practical guidance. You don't want to plough through hundreds of pages or follow up a list of references to other material. Both of these activities use up your precious study time and divert your attention from the subject material of the thesis.

  7. [Medical degree earned with a thesis in medical schools of Lima, 2011: characteristics, motivations and perceptions].

    PubMed

    Mejia, Christian R; Inga-Berrospi, Fiorella; Mayta-Tristán, Percy

    2014-01-01

    We surveyed physicians who obtained their medical degree with a thesis in 2011 from the seven medical schools in Lima to know the characteristics of the degree by thesis process, as well as participants’ motivations and perceptions of that process. We included 98 students who did a thesis (87% of total); 99% conducted observational thesis, 30% did so in groups of three. The main motivation was that it was good for their curriculum vitae (94%). At the university where the thesis is compulsory, the process began with the choice of topic and adviser. Perceived “greatest” and “least” difficulty in the process was the completion of administrative procedures (53%) and selection of their advisor (11%), respectively. Administrative timeliness and processes should be reviewed so as not to impede the completion of thesis, since the new University Act requires the completion of a thesis to graduate.

  8. The polarizability of diatomic helium. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Fortune, P. J.

    1974-01-01

    The calculation of the electric dipole polarizability tensor of the He 2 dimer is described, and the results are used in the computation of several dielectric and optical properties of helium gas, at both high (322 K) and low (4 K) temperatures. The properties considered are the second dielectric virial coefficient, the second Kerr virial coefficient, and the depolarization ratio of the integrated intensities for the Raman scattering experiments. The thesis consists of five parts: the polarizability and various properties are defined; the calculation of the polarizability in the long-range region in terms of a quantum mechanical multipole expansion is described; the calculation of the He2 polarizability in the overlap region via coupled Hartree-Fock perturbation theory is described; the calculation of the quantum pair distribution function for both the He-3 and He-4 isotopes at 4 K is discussed; and the calculated values of the properties of helium gas are given.

  9. The challenge of giving written thesis feedback to nursing students.

    PubMed

    Tuvesson, Hanna; Borglin, Gunilla

    2014-11-01

    Providing effective written feedback on nursing student's assignments can be a challenging task for any assessor. Additionally, as the student groups tend to become larger, written feedback is likely to gain an overall more prominent position than verbal feedback. Lack of formal training or regular discussion in the teaching faculty about the skill set needed to provide written feedback could negatively affect the students' learning abilities. In this brief paper, we discuss written feedback practices, whilst using the Bachelor of Science in Nursing thesis as an example. Our aim is to highlight the importance of an informed understanding of the impact written feedback can have on students. Creating awareness about this can facilitate the development of more strategic and successful written feedback strategies. We end by offering examples of some relatively simple strategies for improving this practice.

  10. NO3- Coordination in Aqueous Solutions by 15N/14N and 18O/natO Isotopic Substitution: What Can We Learn from Molecular Simulation?

    DOE PAGES

    Chialvo, Ariel A.; Vlcek, Lukas

    2014-12-16

    We explore the deconvolution of the water-nitrate correlations by the first-order difference approach involving neutron diffraction of heavy- and null-aqueous solutions of KNO3 under 14N 15N and natON 18ON substitutions to achieve a full characterization of the first water coordination around the nitrate ion. For that purpose we performed isobaric-isothermal simulations of 3.5m KNO3 aqueous solutions at ambient conditions to generate the relevant radial distribution functions (RDF) required in the analysis (a) to identify the individual partial contributions to the total neutron weighted distribution function, (b) to isolate and assess the contribution of NO3 -!K+ pair formation, (c) to testmore » the accuracy of the NDIS-based coordination calculations and XRDbased assumptions, and (d) to describe the water coordination around both the nitrogen and oxygen sites of the nitrate ion.« less

  11. Neutron-induced fission cross section of natPb and Bi209 from threshold to 1 GeV: An improved parametrization

    NASA Astrophysics Data System (ADS)

    Tarrío, D.; Tassan-Got, L.; Audouin, L.; Berthier, B.; Duran, I.; Ferrant, L.; Isaev, S.; Le Naour, C.; Paradela, C.; Stephan, C.; Trubert, D.; Abbondanno, U.; Aerts, G.; Álvarez-Velarde, F.; Andriamonje, S.; Andrzejewski, J.; Assimakopoulos, P.; Badurek, G.; Baumann, P.; Bečvář, F.; Belloni, F.; Berthoumieux, E.; Calviño, F.; Calviani, M.; Cano-Ott, D.; Capote, R.; Carrapiço, C.; Carrillo de Albornoz, A.; Cennini, P.; Chepel, V.; Chiaveri, E.; Colonna, N.; Cortes, G.; Couture, A.; Cox, J.; Dahlfors, M.; David, S.; Dillmann, I.; Dolfini, R.; Domingo-Pardo, C.; Dridi, W.; Eleftheriadis, C.; Embid-Segura, M.; Ferrari, A.; Ferreira-Marques, R.; Fitzpatrick, L.; Frais-Koelbl, H.; Fujii, K.; Furman, W.; Goncalves, I.; González-Romero, E.; Goverdovski, A.; Gramegna, F.; Griesmayer, E.; Guerrero, C.; Gunsing, F.; Haas, B.; Haight, R.; Heil, M.; Herrera-Martinez, A.; Igashira, M.; Jericha, E.; Kadi, Y.; Käppeler, F.; Karadimos, D.; Karamanis, D.; Kerveno, M.; Ketlerov, V.; Koehler, P.; Konovalov, V.; Kossionides, E.; Krtička, M.; Lampoudis, C.; Leeb, H.; Lederer, C.; Lindote, A.; Lopes, I.; Losito, R.; Lozano, M.; Lukic, S.; Marganiec, J.; Marques, L.; Marrone, S.; Martínez, T.; Massimi, C.; Mastinu, P.; Mendoza, E.; Mengoni, A.; Milazzo, P. M.; Moreau, C.; Mosconi, M.; Neves, F.; Oberhummer, H.; O'Brien, S.; Oshima, M.; Pancin, J.; Papachristodoulou, C.; Papadopoulos, C.; Patronis, N.; Pavlik, A.; Pavlopoulos, P.; Perrot, L.; Pigni, M. T.; Plag, R.; Plompen, A.; Plukis, A.; Poch, A.; Praena, J.; Pretel, C.; Quesada, J.; Rauscher, T.; Reifarth, R.; Rosetti, M.; Rubbia, C.; Rudolf, G.; Rullhusen, P.; Salgado, J.; Santos, C.; Sarchiapone, L.; Sarmento, R.; Savvidis, I.; Tagliente, G.; Tain, J. L.; Tavora, L.; Terlizzi, R.; Vannini, G.; Vaz, P.; Ventura, A.; Villamarin, D.; Vlachoudis, V.; Vlastou, R.; Voss, F.; Walter, S.; Wendler, H.; Wiescher, M.; Wisshak, K.

    2011-04-01

    Neutron-induced fission cross sections for natPb and Bi209 were measured with a white-spectrum neutron source at the CERN Neutron Time-of-Flight (n_TOF) facility. The experiment, using neutrons from threshold up to 1 GeV, provides the first results for these nuclei above 200 MeV. The cross sections were measured relative to U235 and U238 in a dedicated fission chamber with parallel plate avalanche counter detectors. Results are compared with previous experimental data. Upgraded parametrizations of the cross sections are presented, from threshold energy up to 1 GeV. The proposed new sets of fitting parameters improve former results along the whole energy range.

  12. Reaction and fusion cross sections for the near-symmetric system 129Xe+natSn from 8 A to 35 A MeV

    NASA Astrophysics Data System (ADS)

    Manduci, L.; Lopez, O.; Chbihi, A.; Rivet, M. F.; Bougault, R.; Frankland, J. D.; Borderie, B.; Galichet, E.; La Commara, M.; Le Neindre, N.; Lombardo, I.; Pârlog, M.; Rosato, E.; Roy, R.; Verde, G.; Vient, E.; Indra Collaboration

    2016-10-01

    Background: We study heavy-ion reactions from barrier up to Fermi energy. The data were acquired with the INDRA detector at the GANIL (Caen, France) facility. Purpose: We aim to determine the reaction and fusion cross sections for the reactions induced by 129Xe projectiles on natSn targets for incident energies ranging from 8 A to 35 A MeV. In particular, the evaluation of the fusion and incomplete fusion cross sections is the main purpose, altogether with the comparison with the systematics of Eudes et al. [Europhys. Lett. 104, 22001 (2013), 10.1209/0295-5075/104/22001]. Method: The reaction cross sections are evaluated at each beam energy with data acquired thanks to the INDRA 4 π array. The events are sorted with the help of the observable Eiso,max. We focus therefore our study on a selected sample of events, in such a way that the fusion and incomplete fusion cross sections can be estimated. Results: We present the excitation function of reaction and fusion cross sections for the heavy and nearly symmetric system 129Xe+natSn from 8 A to 35 A MeV. For the fusion excitation function the comparison with the systematics of Eudes et al. seems to be in a fair agreement starting from the beam energy 20 A MeV. For the lower beam energies (8 A and 12 A MeV) discrepancies are observed. Conclusions: The evaluated fusionlike cross sections show a good agrement with a recent systematics for beam energies greater than 20 A MeV. For low beam energies the cross-sectional values are lower than the expected ones. A probable reason for these low values is in the fusion hindrance at energies above or close to the barrier.

  13. Nozzle Flow with Vibrational Nonequilibrium. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Landry, John Gary

    1995-01-01

    Flow of nitrogen gas through a converging-diverging nozzle is simulated. The flow is modeled using the Navier-Stokes equations that have been modified for vibrational nonequilibrium. The energy equation is replaced by two equations. One equation accounts for energy effects due to the translational and rotational degrees of freedom, and the other accounts for the affects due to the vibrational degree of freedom. The energy equations are coupled by a relaxation time which measures the time required for the vibrational energy component to equilibrate with the translational and rotational energy components. An improved relaxation time is used in this thesis. The equations are solved numerically using the Steger-Warming flux vector splitting method and the Implicit MacCormack method. The results show that uniform flow is produced outside of the boundary layer. Nonequilibrium exists in both the converging and diverging nozzle sections. The boundary layer region is characterized by a marked increase in translational-rotational temperature. The vibrational temperature remains frozen downstream of the nozzle, except in the boundary layer.

  14. The History and Significance of the Incommensurability Thesis

    NASA Astrophysics Data System (ADS)

    Pearce, James Jacob

    The incommensurability thesis (IT) maintains that there are no non-prejudicial means of choosing between competing theories in the empirical sciences. If true, IT would entail that natural science is a fundamentally subjective or irrational activity. Should this latter claim prove justifiable, then empirical science cannot be regarded as an organ of objective knowledge, and "scientific realism" is eo ipso false. I follow the origin of IT from its pre-history in Logical Positivism, through certain preliminary philosophical developments in the work of Karl Popper, W. V. O. Quine, Stephen Toulmin and N. R. Hanson, to the eventual formulation and introduction of IT by Thomas Kuhn and Paul Feyerabend. I then examine the rigorous criticism of IT by various philosophers since about 1964, and discuss different methods of objective theory comparison which have been advanced by such philosophers as Hilary Putnam, W. H. Newton-Smith, Michael Devitt, Hartry Field, Philip Kitcher and Howard Sankey. I conclude by arguing for two counterintuitive claims: (1) Even if true, IT fails to provide evidence against scientific realism. (2) In fact, the truth of IT actually furnishes evidence for a necessary condition for scientific realism, and hence evidence which can be construed as indirectly favorable to scientific realism.

  15. Simulation of plasma motion in the polar ionosphere. Master's Thesis

    SciTech Connect

    Deist, D.W.

    1994-09-01

    A model of plasma motion in the polar ionosphere is presented. Plasma motion due to polar convection and corotation above 50 deg N is modeled. The universal time (UT)-dependent corotation electric field (in the geomagnetic frame) is added to a polar convection electric field that is UT-dependent in the geographic frame and the total is displayed in both reference frames. To simulate actual magnetic conditions, varying polar convection patterns may be used by the model the authors have developed. Trajectories of single plasma parcels and regions of plasma are calculated. The calculated trajectories are displayed in the geographic and magnetic inertial reference frames. The model developed is applied to the study of a region of electron depletion near the pole, a polar hole. Changes in the size and location of the polar hole are explained in terms of a changing convection pattern. The results of this thesis are being used by the Johns Hopkins University Applied Physics Laboratory to further study ionospheric plasma motion.

  16. Geodetic measurement of deformation in California. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Sauber, Jeanne Marie

    1988-01-01

    The very long baseline interferometry (VLBI) measurements made in the western U.S. since 1979 as part of the NASA Crustal Dynamics Project provide discrete samples of the temporal and spatial deformation field. The interpretation of the VLBI-derived rates of deformation requires an examination of geologic information and more densely sampled ground-based geodetic data. In the first two of three related studies embodying this thesis triangulation and trilateration data measured on two regional networks are processed, one in the central Mojave Desert and one in the Coast Ranges east of the San Andreas fault. At the spatial scales spanned by these local geodetic networks, auxiliary geologic and geophysical data have been utilized to examine the relation between measured incremental strain and the accommodation of strain seen in local geological structures, strain release in earthquakes, and principal stress directions inferred from in situ measurements. In the third study, VLBI data from stations distributed across the Pacific - North American plate boundary zone in the western United States are processed. The VLBI data have been used to constrain the integrated rate of deformation across portions of the continental plate boundary in California and to provide a tectonic framework to interpret regional geodetic and geologic studies.

  17. Chinese tactical nuclear weapons. Master`s thesis

    SciTech Connect

    Owens, G.B.

    1996-06-01

    The United States, Russia and Great Britain have retired all nonstrategic nuclear weapons. Surprisingly, China has not, China seems to value highly tactical nuclear weapons (TNWs). Most studies of China`s nuclear arsenal focus on strategic nuclear weapons. This focus could mislead those trying to understand PRC TNW strategy. The purpose of this thesis is to explain China`s TNW development. China`s nuclear arsenal evolution can be described in three phases. In the first phase, China developed a limited strategic nuclear deterrent. China`s arsenal was driven by threat. Technology supplanted threat as the dominant driver during the next phase. While conducting research to miniaturize strategic warheads, were developed. During the third phase, a reduced threat caused political leaders to restrain the nuclear program. The nuclear program reverted to its primary objective - building strategic weapons, causing TNW production to level off. This study explains the last two phases of TNW development. The research goals are twofold: to compare threat and technology, the primary motivations driving TNW production; and to examine the relationship between doctrine and development, describing how one influences the other. The conclusion offers U.S. foreign policy recommendations.

  18. Nuclear-electric magnetohydrodynamic propulsion for submarine. Master's thesis

    SciTech Connect

    Bednarczyk, A.A.

    1989-05-01

    The thesis analyzes the superconducting technology for a shipboard magnetohydrodynamic propulsion system. Based on the the principles of magnetohydrodynamics (MHD), the concept of open-water efficiency was used to optimize the preliminary design of the MHD thruster. After the baseline submarine hull modeled after the Los Angeles class submarine was selected, propulsive efficiency and the top speed for four variant MHD submarines were evaluated. The design criteria were set at a 100-MWt nuclear reactor power upper limit and a requirement of 30 knots for the top speed. This required advanced reactor plants and advanced energy conversion systems. The selection of High Temperature Gas Reactor (HTGR) and Liquid-Metal Fast Breeder Reactor (LMFBR) was based on the combined merits of safety, environmental impact, high source temperature and maximum-volume power density (KW/L). With the reactor outlet temperatures of 2000 K, direct-cycle energy conversion-systems gave the best results in terms of thermal efficiency and propulsion plant power density. Two energy conversion systems selected were closed-cycle gas turbine geared to a superconducting generator, and closed-cycle liquid-metal MHD generator. Based on submarine reliability and safety, the option of using an intermediate heat exchanger was also considered. Finally, non-nuclear support systems affected by the advanced power plant and MHD propulsion, stressing submarine safety, are proposed.

  19. Soviet concepts of ballistic missile defense. Master's thesis

    SciTech Connect

    Seavey, K.P.

    1988-06-01

    This thesis characterizes the Soviet concept of ballistic missile defense (BMD) in order to better understand and predict future Soviet BMD decision making. The Soviet concept of BMD is fundamentally different from that in the West. Soviet BMD is clearly an integral component of a much larger Soviet strategic defense effort which consists of strategic air defense as well as passive measures, such as mobility, deep underground command and control facilities, and civil defense. As the Soviet military literature demonstrates, Soviet strategic air defense encompasses defense against a continuum of threats -- from aircraft to ballistic missiles to satellites to 'space-strike weapons'. Soviet strategic air defense weapons therefore appear optimized to counter a wide range of airborne threats. In the Soviet view, surface-to-air missiles may be a primary tactical BMD weapon. Additionally, Soviet strategic BMD weapons may be a primary Soviet anti-satellite weapon. Furthermore, manned space platforms play a particularly significant role in Soviet thinking about the future of BMD and space warfare.

  20. [Research in general medicine, role of the medical thesis].

    PubMed

    Levasseur, G; Schweyer, F X

    2003-06-01

    General practice doctors are naturally presented as being actors on the front lines of public health. The ability of general practitioners to be aware of and deal with public health questions largely depends upon their training. Perhaps one could consider the general practitioner's thesis as a preparatory analytical work within the area of their future field of practice. Do these theses serve to provide food for thought on general practice and its contribution to public health, and if not, could they? An analysis conducted within four medical schools in western France demonstrates that the work produced for general medicine identified as such only constitutes a fraction of the overall number of medical (non-university) theses (approximately 5%). Two possible explanations may be put forward. First, on the one hand, the theses highly depend on the context of the training and the work produced is a direct result of this. Second, on the other hand, the current methods of indexing notes in the university databases does not enable general medicine to be clearly seen and visibly recognised as an academic discipline. Two questions then remain: Can medical theses be considered as research? Should research in general medicine be carried out solely by general practitioners? It is vital that resources from outside the medical field be raised and mobilised for general practice research, whose themes are multi-disciplinary and not only clinical.

  1. Global lightning activity and climate change. Ph.D. Thesis

    SciTech Connect

    Price, C.G.

    1993-01-01

    The relationship between global lightning frequencies and global climate change is examined in this thesis. In order to study global impacts of climate change, global climate models or General Circulations Models (GCM`s) need to be utilized. Since these models have coarse resolutions many atmospheric phenomena that occur at subgrid scales, such as lightning, need to be parameterized whenever possible. The first chapter introduces a simple parameterization used to simulate total (intracloud and cloud-to-ground) lightning frequencies. The parameterization uses convective cloud top height to approximate lightning frequencies. The second chapter deals with a parameterization for simulating cloud-to-ground (CG) lightning around the globe. This parameterization uses the thickness of the cold cloud sector in thunderstorms (0 C to cloud top) to calculate the proportion of CG flashes in a particular thunderstorm. The third chapter deals with the modelling of lightning in the Goddard Institute for Space Studies (GISS) GCM. This chapter presents results from the model`s control run. The fourth chapter presents two climate change scenarios. One for a climate where the solar constant is reduced by 2% (5.9 C global cooling), and one for a climate with twice the present concentration of CO2 in the atmosphere (4.2 C global warming). The results imply a 24% / 30% decrease/increase in global lightning frequencies for the cooler/warmer climate. The fifth chapter considers the possibility of using the above findings to monitor future global warming. The results show that the earth`s ionospheric potential, which is regulated by global thunderstorm activity, could possibly supply valuable information regarding global surface temperature fluctuations. The sixth and final chapter looks at the implications of changes in both lightning frequencies and the hydrological cycle, as a result of global warming, on natural forest fires.

  2. Marine microbial production of dimethylsulfide from dissolved dimethylsulfoniopropionate. Doctoral thesis

    SciTech Connect

    Ledyard, K.M.

    1993-02-01

    Dimethylsulfide (DMS) plays a central role in the transfer of sulfur from the ocean to the atmosphere, and ultimately to land. The most abundant volatile organosulfur compound in seawater, DMS is believed to account for the bulk of the sea-to-air biogenic sulfur flux. DMS has also been implicated as the major precursor of submicron-sized sulfate aerosol over the ocean. This aerosol acts as an effective site for cloud droplet condensation, suggesting a possibly important role for DMS in marine cloud formation. In the ocean, the precursor of DMS is presumed to be the zwitterionic sulfonium compound dimethylsulfoniopropionate (DMSP), a common osmoticum in certain classes of marine algae. While some algae can cleave DMSP intracellularly to form DMS, correlation of DMS concentrations with indicators of algal productivity on a local scale is poor. This thesis focuses on an alternative pathway of DMS formation: microbial cleavage of dissolved (extracellular) DMSP. In laboratory studies, bacteria able to cleave DMSP to form DMS were isolated from seawater by a DMSP enrichment technique, and the kinetics of DMSP uptake and DMS production were examined closely in pure cultures of a bacterial isolate from the Sargasso Sea. The isolate could grow with both DMSP and acrylic acid, one of the products of DMSP cleavage, as the sole source of carbon and energy, and the enzyme catalyzing DMSP cleavage appeared to be induced by both of these compounds. Kinetic parameters were estimated for DMSP uptake and cleavage by whole cells. Comparison of the 16S rRNA sequence of this isolate with that of known eubacteria showed that it was most closely related to Erythrobacter longus, an aerobic, bacteriochlorophyll-containing member of the alpha proteobacteria.

  3. Spectral Domain Optical Coherence Tomography for Glaucoma (An AOS Thesis)

    PubMed Central

    Schuman, Joel S.

    2008-01-01

    Purpose Optical coherence tomography (OCT) is a rapidly evolving, robust technology that has profoundly changed the practice of ophthalmology. Spectral domain OCT (SD-OCT) increases axial resolution 2- to 3-fold and scan speed 60- to 110-fold vs time domain OCT (TD-OCT). SD-OCT enables novel scanning, denser sampling, and 3-dimensional imaging. This thesis tests my hypothesis that SD-OCT improves reproducibility, sensitivity, and specificity for glaucoma detection. Methods OCT progress is reviewed from invention onward, and future development is discussed. To test the hypothesis, TD-OCT and SD-OCT reproducibility and glaucoma discrimination are evaluated. Forty-one eyes of 21 subjects (SD-OCT) and 21 eyes of 21 subjects (TD-OCT) are studied to test retinal nerve fiber layer (RNFL) thickness measurement reproducibility. Forty eyes of 20 subjects (SD-OCT) and 21 eyes of 21 subjects (TD-OCT) are investigated to test macular parameter reproducibility. For both TD-OCT and SD-OCT, 83 eyes of 83 subjects are assessed to evaluate RNFL thickness and 74 eyes of 74 subjects to evaluate macular glaucoma discrimination. Results Compared to conventional TD-OCT, SD-OCT had statistically significantly better reproducibility in most sectoral macular thickness and peripapillary RNFL sectoral measurements. There was no statistically significant difference in overall mean macular or RNFL reproducibility, or between TD-OCT and SD-OCT glaucoma discrimination. Surprisingly, TD-OCT macular RNFL thickness showed glaucoma discrimination superior to SD-OCT. Conclusions At its current development state, SD-OCT shows better reproducibility than TD-OCT, but glaucoma discrimination is similar for TD-OCT and SD-OCT. Technological improvements are likely to enhance SD-OCT reproducibility, sensitivity, specificity, and utility, but these will require additional development. PMID:19277249

  4. CYP1A2 and NAT2 phenotyping and 3-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in smokers and non-smokers

    SciTech Connect

    Sarkar, Mohamadi; Stabbert, Regina; Kinser, Robin D.; Oey, Jan; Rustemeier, Klaus; Holt, Klaus von; Schepers, Georg; Walk, Roger A.; Roethig, Hans J.

    2006-06-15

    Some aromatic amines are considered to be putative bladder carcinogens. Hemoglobin (Hb) adducts of 3-aminobiphenyl (3-ABP) and 4-aminobiphenyl (4-ABP) have been used as biomarkers of exposure to aromatic amines from cigarette smoke. One of the goals of this study was to determine intra- and inter-individual variability in 3-ABP and 4-ABP Hb adducts and to explore the predictability of ABP Hb adduct levels based on caffeine phenotyping. The study was conducted in adult smokers (S, n = 65) and non-smokers (NS, n 65). The subjects were phenotyped for CYP1A2 and NAT2 using urinary caffeine metabolites. Blood samples were collected twice within 6 weeks and adducts measured by GC/MS. The levels of 4-ABP Hb adducts were significantly (p < 0.0001) greater in S (34.5 {+-} 21.06 pg/g Hb) compared to NS (6.3 {+-} 3.02 pg/g Hb). The levels of 3-ABP Hb adducts were below the limit of quantification (BLOQ) in most (82%) of the NS and about 10-fold lower in S (3.6 {+-} 3.29 pg/g Hb) compared to 4-ABP Hb adducts. No differences were observed in the adduct levels between weeks 1 and 6 in the smokers, suggesting that a single sample would be adequate to monitor cigarette smoke exposure. The regression model developed with CYP1A2, NAT2 phenotype and number of cigarettes smoked (NCIG) accounted for 47% of the variability in 3-ABP adducts, whereas 32% variability in 4-ABP adducts was accounted by CYP1A2 and NCIG. The ratio of 4-ABP Hb adducts in adult S:NS was {approx} 5:1, whereas 3-ABP Hb adducts levels were BLOQ in some S, exhibited large interindividual variability ({approx} 91% compared to 57% for 4-ABP Hb) and poor dose response relationship. Therefore, 4-ABP Hb adduct levels may be a more useful biomarker of aminobiphenyl exposure from cigarette smoke.

  5. Mostly True Confessions: Joint Meaning-Making about the Thesis Journey.

    ERIC Educational Resources Information Center

    McAlpine, Lynn; Weiss, Joel

    2000-01-01

    Examines the thesis process from both student and faculty supervisory perspectives, using the experience of the joint authors as an example. Identifies and questions four assumptions underlying thesis supervision, such as "the supervisor and committee are experts whereas the student is a novice being initiated into the culture." Concludes that the…

  6. A Response to Shelby Gilbert's "A Study of Ogbu and Simons' Thesis"

    ERIC Educational Resources Information Center

    Hawkins, C. Matthew

    2009-01-01

    This article responds to Shelby Gilbert's "A Study of Ogbu and Simon's Thesis." The author begins by saying that he thinks that this study of examining Ogbu and Simons' thesis (to investigate school performance of Black immigrant and non-immigrant students in the United States) makes a thought-provoking contribution to overall discussions…

  7. Supporting the Thesis Writing Process of International Research Students through an Ongoing Writing Group

    ERIC Educational Resources Information Center

    Li, Linda Y.; Vandermensbrugghe, Joelle

    2011-01-01

    Evidence from research suggests writing support is particularly needed for international research students who have to tackle the challenges of thesis writing in English as their second language in Western academic settings. This article reports the development of an ongoing writing group to support the thesis writing process of international…

  8. An Analysis of Current Graduation Thesis Writing by English Majors in Independent Institute

    ERIC Educational Resources Information Center

    Han, Ying

    2014-01-01

    The paper takes 414 graduates from ZJU in 2011 and 2012, NIT as a case, analyzing the status of their writing of graduation thesis. It is found that a considerable number of students have problems in selection and report of topics, writing of each part and debating in the whole process of graduation thesis. In view of the situation, based on the…

  9. Climbing out of the Void: Moving from Chaos to Concepts in the Presentation of a Thesis.

    ERIC Educational Resources Information Center

    Hunt, Cheryl

    2001-01-01

    Describes how and why, after a supervisor's feedback prompted a Ph.D. thesis to be abandoned for over a year, writing resumed in a deliberately reflective style. Highlights parallels between the content of the thesis and the process of writing it. Describes how the experience of writing can be mapped against three models of ways of knowing. (EV)

  10. The Focus of Supervisor Written Feedback to Thesis/Dissertation Students

    ERIC Educational Resources Information Center

    Bitchener, John; Basturkmen, Helen; East, Martin

    2010-01-01

    Written feedback on drafts of a thesis or dissertation is arguably the most important source of input on what is required or expected of thesis-writing students by the academic community. Despite its importance, relatively little is known about what type of information supervisors focus on when giving feedback. This article presents the findings…

  11. Research Survival Skills: Preparing a Master's Thesis, Field Project or Doctoral Dissertation.

    ERIC Educational Resources Information Center

    Pedron, Nadine A.; Evans, Susan B.

    This paper is intended to give graduate level special education students (and others) a structure to facilitate completion of a field study/thesis for a master's degree or a dissertation for the doctorate. First, a format for a dissertation/thesis proposal is suggested and guidelines are offered for development of the proposal. The importance of a…

  12. Student Engagement, Ideological Contest and Elective Affinity: The Zepke Thesis Reviewed

    ERIC Educational Resources Information Center

    Trowler, Paul

    2015-01-01

    This paper takes up issues raised in two articles by Nick Zepke and portrayed here as "the Zepke thesis". This thesis argues that the literature on, interest in and practices around student engagement in higher education have an elective affinity with neo-liberal ideology. At one level this paper counters many of the assertions that…

  13. [Vagotonía. The medical thesis of Salvador Zubirán].

    PubMed

    Delgado, Guillermo; Estañol-Vidal, Bruno

    2012-01-01

    Salvador Zubirán submitted his thesis for his MD degree in 1923. This thesis falls within the context of the new Mexican physiological medicine and denotes the visionary character of its author. Zubirán appears here as the introducer in Mexico of the physiopharmacological approach in autonomic nervous system disorders.

  14. A Tradition Unlike Any Other: Research on the Value of an Honors Senior Thesis

    ERIC Educational Resources Information Center

    Banks, H. Kay

    2016-01-01

    An honors senior thesis introduces students into a world of scholarship and professional activity in a way that no single course, either semester- or year-long, can do (Anderson, Lyons, and Weiner). Many honors educators consider honors thesis work to be the defining honors experience. For graduate schools, employers, and the students themselves,…

  15. Pre-Service Teachers' Beliefs about the Roles of Thesis Supervisors: A Case Study

    ERIC Educational Resources Information Center

    Tapia Carlín, Rebeca Elena

    2013-01-01

    Trainee beliefs about the roles of thesis supervisors can exert an important influence on timely and successful completion of theses. This research article explores pre-service teacher beliefs about the roles of thesis supervisors through the analysis of their learning diaries. The aim of this study is to identify ways to improve supervisory…

  16. Understanding the Up, Back, and Forward-Component in Master's Thesis Supervision with Adaptivity

    ERIC Educational Resources Information Center

    de Kleijn, Renske A. M.; Bronkhorst, Larike H.; Meijer, Paulien C.; Pilot, Albert; Brekelmans, Mieke

    2016-01-01

    Despite the importance of goals in educational theories, goals in master's thesis projects are rarely investigated. Therefore, this study explores how goals play a role in master's thesis supervision in terms of: defining the goals (up-component); locating where the student stands in relation to the goals (back-component); and how the student can…

  17. "Breaking the Mold" in the Dissertation: Implementing a Problem-Based, Decision-Oriented Thesis Project

    ERIC Educational Resources Information Center

    Archbald, Doug

    2010-01-01

    This article offers lessons from an initiative refashioning the doctoral thesis in an education leadership program. The program serves a practitioner clientele; most are teachers and administrators. The new model for the thesis emphasizes leadership, problem solving, decision making, and organizational improvement. The former model was a…

  18. Thesis by Publication in Education: An Autoethnographic Perspective for Educational Researchers

    ERIC Educational Resources Information Center

    Merga, Margaret K.

    2015-01-01

    Despite its growing popularity, the thesis by publication is a less conventional format for doctoral dissertations in the field of education. The author successfully undertook a thesis by publication in education from 2012, to submission in 2014. This paper draws on both the literature in the field and the experiences of the author through an…

  19. Situationally driven local navigation for mobile robots. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Slack, Marc Glenn

    1990-01-01

    For mobile robots to autonomously accommodate dynamically changing navigation tasks in a goal-directed fashion, they must employ navigation plans. Any such plan must provide for the robot's immediate and continuous need for guidance while remaining highly flexible in order to avoid costly computation each time the robot's perception of the world changes. Due to the world's uncertainties, creation and maintenance of navigation plans cannot involve arbitrarily complex processes, as the robot's perception of the world will be in constant flux, requiring modifications to be made quickly if they are to be of any use. This work introduces navigation templates (NaT's) which are building blocks for the construction and maintenance of rough navigation plans which capture the relationship that objects in the world have to the current navigation task. By encoding only the critical relationship between the objects in the world and the navigation task, a NaT-based navigation plan is highly flexible; allowing new constraints to be quickly incorporated into the plan and existing constraints to be updated or deleted from the plan. To satisfy the robot's need for immediate local guidance, the NaT's forming the current navigation plan are passed to a transformation function. The transformation function analyzes the plan with respect to the robot's current location to quickly determine (a few times a second) the locally preferred direction of travel. This dissertation presents NaT's and the transformation function as well as the needed support systems to demonstrate the usefulness of the technique for controlling the actions of a mobile robot operating in an uncertain world.

  20. The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland.

    PubMed

    Pačesová, D; Novotný, J; Bendová, Z

    2016-07-18

    The circadian rhythms of many behavioral and physiological functions are regulated by the major circadian pacemaker in the suprachiasmatic nucleus. Long-term opiate addiction and drug withdrawal may affect circadian rhythmicity of various hormones or the sleep/activity pattern of many experimental subjects; however, limited research has been done on the long-term effects of sustained opiate administration on the intrinsic rhythmicity in the suprachiasmatic nucleus and pineal gland. Here we compared the effects of repeated daily treatment of rats with morphine or methadone and subsequent naloxone-precipitated withdrawal on the expression of the Per1, Per2, and Avp mRNAs in the suprachiasmatic nucleus and on arylalkylamine N-acetyltransferase activity in the pineal gland. We revealed that 10-day administration and withdrawal of both these drugs failed to affect clock genes and Avp expression in the SCN. Our results indicate that opioid-induced changes in behavioral and physiological rhythms originate in brain structures downstream of the suprachiasmatic nucleus regulatory output pathway. Furthermore, we observed that acute withdrawal from methadone markedly extended the period of high night AA-NAT activity in the pineal gland. This suggests that withdrawal from methadone, a widely used drug for the treatment of opioid dependence, may have stronger impact on melatonin synthesis than withdrawal from morphine.

  1. NatB Domain-Containing CRA-1 Antagonizes Hydrolase ACER-1 Linking Acetyl-CoA Metabolism to the Initiation of Recombination during C. elegans Meiosis

    PubMed Central

    Gao, Jinmin; Kim, Hyun-Min; Elia, Andrew E.; Elledge, Stephen J.; Colaiácovo, Monica P.

    2015-01-01

    The formation of DNA double-strand breaks (DSBs) must take place during meiosis to ensure the formation of crossovers, which are required for accurate chromosome segregation, therefore avoiding aneuploidy. However, DSB formation must be tightly regulated to maintain genomic integrity. How this regulation operates in the context of different chromatin architectures and accessibility, and how it is linked to metabolic pathways, is not understood. We show here that global histone acetylation levels undergo changes throughout meiotic progression. Moreover, perturbations to global histone acetylation levels are accompanied by changes in the frequency of DSB formation in C. elegans. We provide evidence that the regulation of histone acetylation requires CRA-1, a NatB domain-containing protein homologous to human NAA25, which controls the levels of acetyl-Coenzyme A (acetyl-CoA) by antagonizing ACER-1, a previously unknown and conserved acetyl-CoA hydrolase. CRA-1 is in turn negatively regulated by XND-1, an AT-hook containing protein. We propose that this newly defined protein network links acetyl-CoA metabolism to meiotic DSB formation via modulation of global histone acetylation. PMID:25768301

  2. Alpha particle induced reactions on natCr up to 39 MeV: Experimental cross-sections, comparison with theoretical calculations and thick target yields for medically relevant 52gFe production

    NASA Astrophysics Data System (ADS)

    Hermanne, A.; Adam Rebeles, R.; Tárkányi, F.; Takács, S.

    2015-08-01

    Thin natCr targets were obtained by electroplating, using 23.75 μm Cu foils as backings. In five stacked foil irradiations, followed by high resolution gamma spectroscopy, the cross sections for production of 52gFe, 49,51cumCr, 52cum,54,56cumMn and 48cumV in Cr and 61Cu,68Ga in Cu were measured up to 39 MeV incident α-particle energy. Reduced uncertainty is obtained by simultaneous remeasurement of the natCu(α,x)67,66Ga monitor reactions over the whole energy range. Comparisons with the scarce literature values and results from the TENDL-2013 on-line library, based on the theoretical code family TALYS-1.6, were made. A discussion of the production routes for 52gFe with achievable yields and contamination rates was made.

  3. Measurement of flux-weight average cross-sections of natZn(γ,xn) reactions in the bremsstrahlung end-point energies of 50, 55, 60, and 65 MeV

    NASA Astrophysics Data System (ADS)

    Zaman, Muhammad; Kim, Guinyun; Naik, Haladhara; Kim, Kwangsoo; Cho, Young-Sik; Lee, Young-Ok; Shin, Sung-Gyun; Cho, Moo-Hyun; Kang, Yeong-Rok; Lee, Man-Woo

    2017-04-01

    The flux-weighted average cross-sections of (γ , xn) reactions on natZn induced by the bremsstrahlung end-point energies of 50, 55, 60, and 65 MeV have been determined by activation and off-line γ-ray spectrometric technique, using the 100 MeV electron linac at the Pohang Accelerator Laboratory (PAL), Pohang, Korea. The theoretical photon-induced reaction cross-sections of natZn as a function of photon energy were taken from TENDL-2014 nuclear data library based on TALYS 1.6 program. The flux-weighted average cross-sections were obtained from the literature data and the theoretical values of TENDL-2014 based on mono-energetic photon. The flux-weighted reaction cross-sections from the present work and literature data at different bremsstrahlung end-point energies are in good agreement with the theoretical values. It was found that the individual natZn(γ , xn) reaction cross-sections increase sharply from reaction threshold to certain values where the next reaction channel opens. There after it remains constant for a while, where the next reaction channel increases. Then it decreases slowly with increase of bremsstrahlung end-point energy due to opening of different reaction channels.

  4. Design of an integrated team project as bachelor thesis in bioscience engineering

    NASA Astrophysics Data System (ADS)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-11-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the design of this thesis. Because of the high number of students and the multidisciplinary nature of the graduates, all research divisions of the faculty are asked to participate. The yearly surveys and hearings were used for further optimisation. The actual design of this bachelor thesis is presented and discussed in this paper.

  5. Preventing ballistic missile proliferation: Lessons from Iraq. Master`s thesis

    SciTech Connect

    Talay, B.J.

    1996-12-01

    This thesis examines the case of Iraq to assess the performance of the missile nonproliferation regime since 1970. By analyzing the methods used by Iraq to obtain missile systems and missile technology, this thesis assesses the ability of the international community to prevent ballistic missile proliferation. Understanding Iraq`s past capabilities as well as its post-war efforts to rebuild weapons programs and procurement networks, this thesis provides suggestions for improving the regime`s performance. This thesis finds that (1) prior to 1992, the Missile Technology Control Regime (MTCR) failed in its attempts to prevent proliferation; (2) the existence of the MTCR, while necessary to slow proliferation, is not sufficient to prevent proliferation; and (3) additional enforcement is needed to counter weapons of mass destruction acquisition by resourceful and determined states.

  6. Thesis/Dissertation Writing for EFL Students: An ESP Course Design.

    ERIC Educational Resources Information Center

    Richards, Rebecca T.

    1988-01-01

    Describes an intensive English for Specific Purposes (ESP) thesis-writing course. The course focuses on total discourse learning needs and uses an interactive model of needs analysis to target the learning needs of students. (Author/CB)

  7. Studies of an x ray selected sample of cataclysmic variables. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Silber, Andrew D.

    1986-01-01

    Just prior to the thesis research, an all-sky survey in hard x rays with the HEAO-1 satellite and further observations in the optical resulted in a catalog of about 700 x-ray sources with known optical counterparts. This sample includes 43 cataclysmic variables, which are binaries consisting of a detached white-dwarf and a Roche lobe filling companion star. This thesis consists of studies of the x-ray selected sample of catalcysmic variables.

  8. Dissertations and Theses Roles Highlighted at Annual Meeting Session. California State University System's Thesis in Master's Degree Programs Discussed.

    ERIC Educational Resources Information Center

    Stanford, Serena W.

    1987-01-01

    The role of the thesis in graduate education at the 19 campuses of the California State University (CSU) was surveyed. It was found that a minimal number of disciplines at CSU restrict the choice of culminating the degree with the thesis. Only 15% of the programs systemwide force the thesis. The comprehensive examination was as popular as the…

  9. The Honors Thesis: A Handbook for Honors Directors, Deans, and Faculty Advisors. National Collegiate Honors Council Monograph Series

    ERIC Educational Resources Information Center

    Anderson, Mark; Lyons, Karen; Weiner, Norman

    2014-01-01

    This handbook is intended to help all those who design, administer, and implement honors thesis programs--honors directors, deans, staff, faculty, and advisors--evaluate their thesis programs, solve pressing problems, select more effective requirements or procedures, or introduce an entirely new thesis program. The authors' goal is to provide…

  10. Is Hong Kong experiencing normalization of adolescent drug use? Some reflections on the normalization thesis.

    PubMed

    Cheung, Nicole W T; Cheung, Yuet W

    2006-01-01

    The upsurge of consumption of party drugs among adolescents in recent years in Hong Kong has been part of the global trend of adolescent recreational use of drugs at rave parties, discos and similar party settings. Scholars in Western societies have recently proposed the thesis of "normalization of adolescent drug use" to describe such a trend. The normalization thesis points at three major aspects of the normalization phenomenon, namely, a rapid increase of the prevalence of drug use in young people, the widespread popularity of recreational drug use that is closely linked with the recent arrival of dance club culture, and a receptive attitude towards drug use as a normal part of leisure. This article aims to examine whether the normalization thesis can be applied to analyze the situation of adolescent drug use in Hong Kong. Data are drawn from official statistics and a recent survey conducted in 2002-2004 of drug use of Hong Kong marginal youths (N = 504). The case of Hong Kong only partially supports the thesis. Our findings show that the normalization of drug use among young people has occurred in Hong Kong, but the extent of normalization is smaller than those in Western societies like the United Kingdom. They also suggest that a recognition of possible cultural differences may be complementary to the normalization thesis. Limitations of the study are also noted.

  11. Assessment of dental student satisfaction with regard to process of thesis educational courses

    PubMed Central

    Eslamipour, Faezeh; Noroozi, Zahra; Hosseinpour, Kobra

    2015-01-01

    Introduction: Ensuring achievement of research experience by students is one of the most important goals of the thesis-conduction process and evaluation of student satisfaction with this process is one of the most imperative challenges herein. Aims: The aim of this study is to investigate the satisfaction of dental students passing the thesis educational course from the Isfahan Dental School. Settings and Design: Sixty-two dental students who had graduated in2011, from the Isfahan Dental School, participated in this descriptive cross-sectional study Materials and Methods: The postgraduate Research Experience Questionnaire (PREQ) was used for data collection. The questionnaire evaluated student satisfaction in seven domains: Thesis supervision, skill development, intellectual climate, infrastructure, thesis examination, goals and expectations, and overall satisfaction. Statistical Analysis Used: The data were analyzed on an SPSS software using descriptive and inferential statistics. Results: The mean score of satisfaction of the participants was 75 ± 12. On the basis of their scores, satisfaction in 3.2% of them was slow, in 33.9%was medium, in 61.3% was good and in 1.6% was high. The highest satisfaction was found to be in thesis supervision and the least was in the intellectual climate domain. There was no significant statistical difference between satisfaction and gender (P = 0.46). Conclusions: Considering the results, to increase student satisfaction for passing the thesis courses, it is necessary to improve the intellectual climate in dental schools and also increase the research budget for more financial support of students to carry out their projects. PMID:27462643

  12. An Auto-management Thesis Program WebMIS Based on Workflow

    NASA Astrophysics Data System (ADS)

    Chang, Li; Jie, Shi; Weibo, Zhong

    An auto-management WebMIS based on workflow for bachelor thesis program is given in this paper. A module used for workflow dispatching is designed and realized using MySQL and J2EE according to the work principle of workflow engine. The module can automatively dispatch the workflow according to the date of system, login information and the work status of the user. The WebMIS changes the management from handwork to computer-work which not only standardizes the thesis program but also keeps the data and documents clean and consistent.

  13. Application of a neptune propulsion concept to a manned mars excursion. Master's thesis

    SciTech Connect

    Finley, C.J.

    1993-04-01

    NEPTUNE is a multimegawatt electric propulsion system. It uses a proven compact nuclear thermal rocket, NERVA, in a closed cycle with a magnetohydrodynamic (MHD) generator to power a magnetoplasmadynamic (MPD) thruster. This thesis defines constraints on an externally sourced propulsion system intended to carry out a manned Martian excursion. It assesses NEPTUNE's ability to conform to these constraints. Because an unmodified NEPTUNE system is too large, the thesis develops modifications to the system which reduce its size. The result is a far less proven, but more useful derivative of the unmodified NEPTUNE system.

  14. Probability density functions characterizing PSC particle size distribution parameters for NAT and STS derived from in situ measurements between 1989 and 2010 above McMurdo Station, Antarctica, and between 1991-2004 above Kiruna, Sweden

    NASA Astrophysics Data System (ADS)

    Deshler, Terry

    2016-04-01

    Balloon-borne optical particle counters were used to make in situ size resolved particle concentration measurements within polar stratospheric clouds (PSCs) over 20 years in the Antarctic and over 10 years in the Arctic. The measurements were made primarily during the late winter in the Antarctic and in the early and mid-winter in the Arctic. Measurements in early and mid-winter were also made during 5 years in the Antarctic. For the analysis bimodal lognormal size distributions are fit to 250 meter averages of the particle concentration data. The characteristics of these fits, along with temperature, water and nitric acid vapor mixing ratios, are used to classify the PSC observations as either NAT, STS, ice, or some mixture of these. The vapor mixing ratios are obtained from satellite when possible, otherwise assumptions are made. This classification of the data is used to construct probability density functions for NAT, STS, and ice number concentration, median radius and distribution width for mid and late winter clouds in the Antarctic and for early and mid-winter clouds in the Arctic. Additional analysis is focused on characterizing the temperature histories associated with the particle classes and the different time periods. The results from theses analyses will be presented, and should be useful to set bounds for retrievals of PSC properties from remote measurements, and to constrain model representations of PSCs.

  15. Measurements of 67Ga production cross section induced by protons on natZn in the low energy range from 1.678 to 2.444 MeV

    NASA Astrophysics Data System (ADS)

    Wachter, J. A.; Miranda, P. A.; Morales, J. R.; Cancino, S. A.; Correa, R.

    2015-02-01

    The experimental production cross section for the reaction natZn(p,x)67Ga has been measured in the energy range from 1.678 to 2.444 MeV. The methodology used in this work is based on characteristic X-ray emitted after irradiation by the daughter nuclei that decays by electron capture (EC) and the use of a complementary PIXE experiment. By doing so, expressions needed to determine cross section values are simplified since experimental factors such as geometric setup and an detector efficiency are avoided. 67Ga is a radionuclide particularly suited for this method since it decays by electron capture in 100% and the subsequent characteristic X-ray emission is easily detected. Natural zinc targets were fabricated by PVD technique and afterwards their thicknesses were determined by Rutherford Backscattering Spectrometry. Cross sections measurements were carried out by using the Van de Graaff accelerator located at Faculty of Sciences, University of Chile. It was found that our data for the natZn(p,x)67Ga reaction are, in general, in good agreement when compared to existing experimental data and to those calculated ALICE/ASH nuclear code. On the other hand, values predicted by Talys-1.6 are showing systematically lower magnitudes than our measured data.

  16. The Experienced Meaning of Working with a PhD Thesis

    ERIC Educational Resources Information Center

    Stubb, Jenni; Pyhalto, Kirsi; Lonka, Kirsti

    2012-01-01

    There is a variation in terms of how researchers perceive the nature of research work. Previous research has mainly looked at the members of academia who already have established themselves in the scholarly community. We aimed at exploring the ways in which doctoral students perceived their thesis project and further, the relations of such…

  17. Design of an Integrated Team Project as Bachelor Thesis in Bioscience Engineering

    ERIC Educational Resources Information Center

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-01-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the…

  18. An Analysis of Written Feedback on a PhD Thesis

    ERIC Educational Resources Information Center

    Kumar, Vijay; Stracke, Elke

    2007-01-01

    This paper offers an interim analysis of written feedback on a first draft of a PhD thesis. It first looks at two sources of data: in-text feedback and overall feedback. Looking at how language is used in its situational context, we then coded the feedback and developed a model for analysis based on three fundamental functions of speech:…

  19. Reconsidering the Compatibility Thesis and Eclecticism: Five Proposed Guidelines for Method Use

    ERIC Educational Resources Information Center

    Yanchar, Stephen C.; Williams, David D.

    2006-01-01

    This essay examines calls for methodological eclecticism based on the "compatibility thesis," arguing that they fail to take seriously the assumptions of method and, in so doing, fail to provide a methodological perspective that adequately incorporates the centrally important task of critically examining the theoretical background of methods and…

  20. Testing the Protestant Ethic Thesis with Quantitative Historical Data: A Research Note

    ERIC Educational Resources Information Center

    Sanderson, Stephen K.; Abrutyn, Seth B.; Proctor, Kristopher R.

    2011-01-01

    We provide a test of the thesis that Protestantism influenced the development of modern capitalism by using quantitative data from 1500 through 1870. Results show that during this period the percentage of a country's population that is Protestant is unrelated to both its level of per capita GDP and the average rate of its annual growth in per…

  1. Evaluability Assessment Thesis and Dissertation Studies in Graduate Professional Degree Programs

    ERIC Educational Resources Information Center

    Walser, Tamara M.; Trevisan, Michael S.

    2016-01-01

    Evaluability assessment (EA) has potential as a design option for thesis and dissertation studies, serving as a practical training experience for both technical and nontechnical evaluation skills. Based on a content review of a sample of EA theses and dissertations from graduate professional degree programs, the authors of this article found that…

  2. Diversity in Collaborative Research Communities: A Multicultural, Multidisciplinary Thesis Writing Group in Public Health

    ERIC Educational Resources Information Center

    Guerin, Cally; Xafis, Vicki; Doda, Diana V.; Gillam, Marianne H.; Larg, Allison J.; Luckner, Helene; Jahan, Nasreen; Widayati, Aris; Xu, Chuangzhou

    2013-01-01

    Writing groups for doctoral students are generally agreed to provide valuable learning spaces for Ph.D. candidates. Here an academic developer and the eight members of a writing group formed in a Discipline of Public Health provide an account of their experiences of collaborating in a multicultural, multidisciplinary thesis writing group. We…

  3. The Quality of an Action Research Thesis in the Social Sciences

    ERIC Educational Resources Information Center

    Zuber-Skerrit, Ortrun; Fletcher, Margaret

    2007-01-01

    Purpose: The paper seeks to identify the quality characteristics of critical action research and action research theses compared to traditional research thesis writing. Design/methodology/approach: Drawing on the literature and the authors' experience with supervising and examining action research theses, the paper identifies key problem areas in…

  4. Perceptions of the Difficulties of Postgraduate L2 Thesis Students Writing the Discussion Section

    ERIC Educational Resources Information Center

    Bitchener, John; Basturkmen, Helen

    2006-01-01

    In postgraduate study, students including L2 students are often required to write a thesis and, as a growing literature reveals, L2 students often experience difficulties in the writing of this genre. While most of this research has involved surveys (questionnaires and interviews) and case studies of supervisor perceptions, only a few studies have…

  5. The "Write" Skills and More: A Thesis Writing Group for Doctoral Students

    ERIC Educational Resources Information Center

    Ferguson, Therese

    2009-01-01

    Writing groups facilitate the development of research students' written communication skills, which are critical for the competent preparation of theses and publications. This paper describes a Thesis Writing Group for social science doctoral students. Participants indicated that the group not only served a practical role, providing an impetus for…

  6. Reading in Preparation for Writing a PhD Thesis: Case Studies of Experiences

    ERIC Educational Resources Information Center

    Kwan, Becky S. C.

    2009-01-01

    The paper presents stories of how a group of doctoral students chose the key disciplinary literature that they read in preparation for their thesis-undertaking (RT). The stories were analyzed in light of current understanding of literature reviewing as a situated practice and theory of doctoral education as socio-cognitive apprenticeship. As the…

  7. The sonata form of musical composition as a framework for thesis writing.

    PubMed

    Drake, Maurice C

    2004-01-01

    In response to Watson's challenge to view the usual in new ways, this article introduces an innovation in writing Master's research and suggests that other structures may offer new and different frameworks for reporting nursing research. This is exemplified by reference to an example of nursing research which adopted the sonata-form of musical composition as the framework for presentation of the thesis.

  8. Want to Improve Undergraduate Thesis Writing? Engage Students and Their Faculty Readers in Scientific Peer Review

    ERIC Educational Resources Information Center

    Reynolds, Julie A.; Thompson, Robert J., Jr.

    2011-01-01

    One of the best opportunities that undergraduates have to learn to write like a scientist is to write a thesis after participating in faculty-mentored undergraduate research. But developing writing skills doesn't happen automatically, and there are significant challenges associated with offering writing courses and with individualized mentoring.…

  9. Rapid X-Ray Variability of Active Galaxies. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Tennant, A. F., Jr.

    1983-01-01

    Active galactic nuclei are luminous sources of X-rays. The thesis that the X-rays are generated within 10 gravitational radii from the central object is tested. A very sensitive search for rapid ( 1 day) X-ray variability from active galaxies was made.

  10. Edgeware Security Risk Management: A Three Essay Thesis on Cloud, Virtualization and Wireless Grid Vulnerabilities

    ERIC Educational Resources Information Center

    Brooks, Tyson T.

    2013-01-01

    This thesis identifies three essays which contribute to the foundational understanding of the vulnerabilities and risk towards potentially implementing wireless grid Edgeware technology in a virtualized cloud environment. Since communication networks and devices are subject to becoming the target of exploitation by hackers (e.g. individuals who…

  11. Increasing the Number of Feminist Scientists: Why Feminist Aims Are Not Served by the Underdetermination Thesis

    ERIC Educational Resources Information Center

    Intemann, Kristen

    2008-01-01

    Recent feminist philosophers of science have argued that feminist values can contribute to rational decisions about which scientific theories to accept. On this view, increasing the number of feminist scientists is important for ensuring rational and objective theory acceptance. The Underdetermination Thesis has played a key role in arguments for…

  12. Unblocking Occluded Genres in Graduate Writing: Thesis and Dissertation Support Services at North Carolina State University

    ERIC Educational Resources Information Center

    Autry, Meagan Kittle; Carter, Michael

    2015-01-01

    In 2013, the Graduate School at North Carolina State University launched Thesis and Dissertation Support Services, a rhetorical, genre-based approach to assisting students with their graduate writing. Through a description of the program's founding, goals, and first year of services, we summarize this genre-based approach that is informed by the…

  13. Thesis and Dissertation Writing: An Examination of Published Advice and Actual Practice.

    ERIC Educational Resources Information Center

    Paltridge, Brian

    2002-01-01

    Explores the extent to which published advice on the organization and structure of theses and dissertations concurs with what happens in actual practice. Examines guides and handbooks that focus on thesis and dissertation writing and postgraduate research. Found that only a few books devoted a substantial amount of space to this topic. Discusses…

  14. Curricular Goals and Personal Goals in Master's Thesis Projects: Dutch Student-Supervisor Dyads

    ERIC Educational Resources Information Center

    de Kleijn, Renske A. M.; Meijer, Paulien C.; Brekelmans, Mieke; Pilot, Albert

    2013-01-01

    To be effective, feedback should be goal-related. In order to better understand goal-related feedback in Master's thesis projects, the present study explores the goals of supervisors and students in supervision dyads and similarities and differences within and between these dyads. Twelve supervisors and students were interviewed, and their goals…

  15. Episodic stress associated with writing a graduation thesis and free cortisol secretion after awakening.

    PubMed

    Izawa, Shuhei; Sugaya, Nagisa; Ogawa, Namiko; Nagano, Yuichiro; Nakano, Masako; Nakase, Emiko; Shirotsuki, Kentaro; Yamada, Kosuke Chris; Machida, Kazuhiko; Kodama, Masahisa; Nomura, Shinobu

    2007-05-01

    Cortisol secretion after awakening, an index of hypothalamus-pituitary-adrenal axis activity, appears to be related to psychosocial stressors, or to symptoms caused by psychosocial stressors. The relationship between the quality, duration, and magnitude of psychosocial factors and cortisol secretion is however, unclear. Therefore, the effect of episodic stress associated with writing a graduation thesis on cortisol secretion after awakening was investigated. Saliva samples were collected from 10 undergraduate students at awakening, and 30, 45, and 60 min after awakening 1 month, 2 weeks, and a few days before the thesis submission and 1 week after the submission. They also completed the Short form of Profile of Moods Scale (POMS-S) on the night before each sampling. Results indicated that cortisol levels were higher a few days before the thesis submission compared to 1 month before submission. Scores of "Fatigue" and "Tension-Anxiety" in POMS-S were also higher a few days before submission. These results suggest that episodic stress associated with writing a graduation thesis caused an increase in cortisol levels after awakening.

  16. [High frequency of plagiarism in medical thesis from a Peruvian public university].

    PubMed

    Saldaña-Gastulo, J Jhan C; Quezada-Osoria, C Claudia; Peña-Oscuvilca, Américo; Mayta-Tristán, Percy

    2010-03-01

    An observational study was conducted to describe the presence of plagiarism in medical thesis in 2008 performed at a public university in Peru. Search for plagiarism in 33 thesis introductions using a Google search algorithm, characterizes of the study type and we search in electronic form if the thesis mentor have published articles in scientific journals. We found evidence of plagiarism in 27/33 introductions, 37.3% (171/479) of all the paragraphs analyzed had some degree of plagiarism, literal plagiarism was the most frequent (20/27) and journals were the most common sources of plagiarism (19/27). The characteristics of the studies were observational (32/33), cross-sectional (30/33), descriptive (25/33) and retrospective (19/33). None of the authors had published in a scientific journal, and only nine of his tutors of them had at least one publication. No association was found between the characteristics of the thesis and the presence of plagiarism. In conclusion, we found a high frequency of plagiarism in theses analyzed. Is responsibility of medical schools take the necessary actions to detect and avoid plagiarism among their students.

  17. What Do They Master? Perceived Benefits of the Master's Thesis Experience.

    ERIC Educational Resources Information Center

    Demb, Ada; Funk, Kelly

    1999-01-01

    Studied the learning outcomes experienced by 24 alumni of a higher education/student affairs program through interviews with the students and some faculty and support staff members. Students experienced the thesis process in eight identifiable stages, and four areas of growth were identified: personal development, skills development, content…

  18. The Relation between Feedback Perceptions and the Supervisor-Student Relationship in Master's Thesis Projects

    ERIC Educational Resources Information Center

    de Kleijn, Renske A. M.; Meijer, Paulien C.; Pilot, Albert; Brekelmans, Mieke

    2014-01-01

    Research supervision can be investigated from social-emotional and cognitive perspectives, but most studies include only one perspective. This study aims to understand the interplay between a social-emotional (supervisor-student relationship) and cognitive (feedback) perspective on the outcomes of master's thesis supervision in specific, by…

  19. "On Course" for Supporting Expanded Participation and Improving Scientific Reasoning in Undergraduate Thesis Writing

    ERIC Educational Resources Information Center

    Dowd, Jason E.; Roy, Christopher P.; Thompson, Robert J., Jr.; Reynolds, Julie A.

    2015-01-01

    The Department of Chemistry at Duke University has endeavored to expand participation in undergraduate honors thesis research while maintaining the quality of the learning experience. Accomplishing this goal has been constrained by limited departmental resources (including faculty time) and increased diversity in students' preparation to engage in…

  20. The Two-Semester Thesis Model: Emphasizing Research in Undergraduate Technical Communication Curricula

    ERIC Educational Resources Information Center

    Ford, Julie Dyke; Bracken, Jennifer L.; Wilson, Gregory D.

    2009-01-01

    This article addresses previous arguments that call for increased emphasis on research in technical communication programs. Focusing on the value of scholarly-based research at the undergraduate level, we present New Mexico Tech's thesis model as an example of helping students develop familiarity with research skills and methods. This two-semester…

  1. Learning Cultures in Travel and Tourism: A Critique of Manuela du Bois-Reymond's Trendsetter Learner Thesis

    ERIC Educational Resources Information Center

    Morrison, Andrew

    2011-01-01

    This article aims to contribute to the discussion surrounding Manuela du Bois-Reymond's important "trendsetter learner" thesis and, in so doing, to join the wider debate about post-compulsory learning cultures. The article outlines the trendsetter learner thesis and then considers recent criticisms that it has attracted. While the author…

  2. Final Thesis Models in European Teacher Education and Their Orientation towards the Academy and the Teaching Profession

    ERIC Educational Resources Information Center

    Råde, Anders

    2014-01-01

    This study concerns different final thesis models in the research on teacher education in Europe and their orientation towards the academy and the teaching profession. In scientific journals, 33 articles support the occurrence of three models: the portfolio model, with a mainly teaching-professional orientation; the thesis model, with a mainly…

  3. Where's Your Thesis Statement and What Happened to Your Topic Sentences? Identifying Organizational Challenges in Undergraduate Student Argumentative Writing

    ERIC Educational Resources Information Center

    Miller, Ryan T.; Pessoa, Silvia

    2016-01-01

    The authors examine the challenges students faced in trying to write organized texts using effective thesis statements and topic sentences by analyzing argumentative history essays written by multilingual students enrolled in an undergraduate history course. They use the notions of macro-Theme (i.e., thesis statement) and hyper-Theme (i.e., topic…

  4. A Cross-Country Study on Research Students' Perceptions of the Role of Supervision and Cultural Knowledge in Thesis Development

    ERIC Educational Resources Information Center

    McGinty, Suzanne Claire; Koo, Yew Lie; Saeidi, Mahnaz

    2010-01-01

    This paper presents preliminary findings from a research study in Australia, Malaysia and Iran on students' perceptions of the roles of supervisor and student in the production of their thesis and the contribution of their cultural knowledge to thesis development. The 360 respondents who answered an online survey were studying for their Master's…

  5. Two arm robot path planning in a static environment using polytopes and string stretching. Thesis

    NASA Technical Reports Server (NTRS)

    Schima, Francis J., III

    1990-01-01

    The two arm robot path planning problem has been analyzed and reduced into components to be simplified. This thesis examines one component in which two Puma-560 robot arms are simultaneously holding a single object. The problem is to find a path between two points around obstacles which is relatively fast and minimizes the distance. The thesis involves creating a structure on which to form an advanced path planning algorithm which could ideally find the optimum path. An actual path planning method is implemented which is simple though effective in most common situations. Given the limits of computer technology, a 'good' path is currently found. Objects in the workspace are modeled with polytopes. These are used because they can be used for rapid collision detection and still provide a representation which is adequate for path planning.

  6. The new "new racism" thesis: limited government values and race-conscious policy attitudes.

    PubMed

    Gainous, Jason

    2012-01-01

    Some contend that Whites’ application of values to form opinions about race-conscious policy may constitute a subtle form of racism. Others challenge the new racism thesis, suggesting that racism and values are exclusive in their influence. Proponents of the thesis assert that many Whites’ attitudes about such policy are structured by a mix of racism and American individualism. The author suggests that an even more subtle form of racism may exist. Racism may actually be expressed in opposition to big government. The test results presented here indicate that the effects of limited-government values on attitudes about race-conscious policy are conditional on levels of racial prejudice for many Whites, whereas the effects on racially ambiguous social welfare policy attitudes are not. The author contends that these results provide support to the argument that racism still exists and has found a new subtle expression.

  7. Water quality management of bilge wastes at Pearl Harbor, Hawaii. Master's thesis

    SciTech Connect

    Bernotas, S.

    1992-12-01

    The Navy, requires a new method to collect and treat the bilge waste discharged from U.S. Navy Ships. This thesis recommends an interim plan, which can be implemented in a relatively short time frame, and a permanent plan which will take several years to implement. Although a permanent solution is recommended, the focus of this thesis is on what can be done now (interim plan) to collect and treat the bilge waste. The interim plan calls for collection of the bilge waste using pump trucks and barges. The collected bilge waste would then be processed by an oil/water separator, with the separated oil being recycled. The nonoily, separator effluent would then be prefiltered and processed through a reverse osmosis unit.

  8. Protestant Clergy and the Culture Wats: An Empirical Test of Hunter's Thesis.

    PubMed

    Uecker, Jeremy E; Lucke, Glenn

    2011-12-01

    This study instead focuses on culture wars among religious elites-clergy-and tests three aspects of the culture wars thesis: (1) whether cultural wars exist at all among religious elites, (2) whether clergy attitudes are polarized on these issues, and (3) whether religious authority or religious affiliation is more salient in creating culture wars cleavages. Using data from a large random sample of Protestant clergy, we find a substantial amount of engagement in culture wars by all types of Protestant clergy. The amount of polarization is more attributable to views of religious authority (i.e., biblical inerrancy) than to religious tradition. Moreover, polarization among clergy is somewhat more evident on culture wars issues than on other social and political issues. These findings are generally supportive of the culture wars thesis and should help return examinations of culture wars back to where they were originally theorized to be waged: among elites.

  9. Protestant Clergy and the Culture Wats: An Empirical Test of Hunter’s Thesis

    PubMed Central

    Uecker, Jeremy E.; Lucke, Glenn

    2013-01-01

    This study instead focuses on culture wars among religious elites—clergy—and tests three aspects of the culture wars thesis: (1) whether cultural wars exist at all among religious elites, (2) whether clergy attitudes are polarized on these issues, and (3) whether religious authority or religious affiliation is more salient in creating culture wars cleavages. Using data from a large random sample of Protestant clergy, we find a substantial amount of engagement in culture wars by all types of Protestant clergy. The amount of polarization is more attributable to views of religious authority (i.e., biblical inerrancy) than to religious tradition. Moreover, polarization among clergy is somewhat more evident on culture wars issues than on other social and political issues. These findings are generally supportive of the culture wars thesis and should help return examinations of culture wars back to where they were originally theorized to be waged: among elites. PMID:24072933

  10. Health science students' experiences of group supervision of the bachelor's thesis.

    PubMed

    Utriainen, Kati; Ahonen, Sanna-Mari; Kangasniemi, Mari; Liikanen, Eeva

    2011-04-01

    This study aimed to describe health science university students' experiences of group supervision of the bachelor's thesis. Sixty-one students responded to questions on an open data collection form, and the data were analyzed by using qualitative inductive content analysis. According to the students, group supervision is supportive in terms of joint learning as well as commitment-enhancing and participative learning, but it also can be useless from the viewpoint of an individual student's own thesis. Teachers' role as experts and active directors of the group, students' commitment to learn together, and workable practical organization of the group were promoting factors, whereas students' timetable problems, mismatch between received and needed supervision, and difficulties in supervising other students were restraining factors. The results can be used for developing group supervision in higher health education.

  11. Current developments and prospects for the future: French security policy in a changing world. Master's thesis

    SciTech Connect

    Graham, J.M.

    1991-06-01

    This thesis provides an analysis of the effects of recent historical events on the future of French security policy. The end of the Cold War division of Europe, the rebirth of Germany, the growing pressures for major defense cuts, the calls for France to review its nuclear doctrine, abandon its independent policies and rejoin NATO's integrated military structure, and finally, the lessons of the recent Gulf War, are issues that threaten to divide France in a way that has not occurred in several decades. The fundamental question for the decade of the 1990s is how to, or perhaps whether to, preserve the legacy of national independence and grandeur handed down by former President Charles de Gaulle. The thesis concludes that the Gaullist myth of grandeur and independence can no longer be sustained. French security must now be achieved by strengthening ties with NATO, and building a stronger West European defense posture centered around close Franco-German relations.

  12. [Doctor's degree thesis of Tomasz Adolf Wołkowiński "Carditidis rheumaticae historia"].

    PubMed

    Stembrowicz, W

    2001-01-01

    In 1817 on the University of Vilnius Faculty of Medicine, T. A. Wołkowiński, a student of the eminent clinician Józef Frank, defended his doctor's degree thesis about a direct relation between rheumatic disease and cardiomegaly. It was probably the first paper in Poland describing with details the rheumatic heart disease. Unfortunately we don't know much about T. A. Wołkowiński's life.

  13. Increasing the number of feminist scientists: why feminist aims are not served by the Underdetermination Thesis

    NASA Astrophysics Data System (ADS)

    Intemann, Kristen

    2008-11-01

    Recent feminist philosophers of science have argued that feminist values can contribute to rational decisions about which scientific theories to accept. On this view, increasing the number of feminist scientists is important for ensuring rational and objective theory acceptance. The Underdetermination Thesis has played a key role in arguments for this view [Anderson (1995) Hypatia 10(3), 50 84; Hankinson Nelson (1990) Who knows? From Quine to a feminist empiricism. Temple University Press, Philadelphia; Longino (1990) Science as social knowledge. Princeton University Press, Princeton; Longino (2002) The fate of knowledge. Princeton University Press, Princeton; Kourany (2003) Philosophy of Science 70, 1 14]. This thesis is alleged to open an argumentative “gap” between evidence and theory acceptance and provide a rationale for filling the gap with feminist values. While I agree with the conclusion that feminist values can contribute to rational decisions about which theories to accept, I argue that the Underdetermination Thesis cannot support this claim. First, using earlier arguments [Laudan (1990) in: R. Giere (ed) Minnesota studies in the philosophy of science, vol 14, pp 267 297; Slezak (1991) International Studies in Philosophy of Science 5, 241 256; Pinnick (1994) Philosophy of Science 61, 664 657] I show that Underdetermination cannot, by itself, establish that feminist values should fill the gap in theory acceptance. Secondly, I argue that the very use of the Underdetermination Thesis concedes that feminist values are extra-scientific, a-rational, factors in theory acceptance. This concession denies feminists grounds to explain why their values contribute to rational scientific reasoning. Finally, I propose two alternative ways to explain how feminist values can contribute to rational theory acceptance that do not rely on Underdetermination.

  14. [Eleven thesis on the archive of scientific research, for a new patrimonial and scientific policy].

    PubMed

    Müller, Bertrand

    2015-12-01

    Abstracting the main content of a recent report on the bad state of the archives of scientific research, this paper puts forward eleven thesis likely to feed, in this time of numeric transition to a new documentary regime and to a new patrimonial policy. The recent numeric conditions impose to set new archival pratices, more proactive, anticipative and prospective. Archives of scientific research must be thought in a double memorial and scientific dimension, and not only as a patrimonial or historical one.

  15. How to survive (and enjoy) doing a thesis: the experiences of a methodological working group.

    PubMed

    Giddings, Lynne S; Wood, Pamela J

    2006-03-01

    'Doing a thesis', whether for Masters or PhD, can be a lonely and tortuous journey. This article offers a complementary process to the traditional apprenticeship supervision model. It describes the experiences of students who during their thesis research met monthly in a grounded theory working group. They reflected on their experiences during a focus group interview. After describing the background to how the group started in 1999 and exploring some of the ideas in the literature concerning the thesis experience, the article presents the interview. To focus the presentation, specific questions are used as category headings. Overall, the participants found attending the group was a "life-line" that gave them "hope" and was complementary to the supervision process. Through the support of peers, guidance from those ahead in the process, and consultancy with teachers and visiting methodological scholars, these students not only successfully completed their theses, but reported that they had some enjoyment along the way. This is the fifteenth in a series of articles which have been based on interviews with nursing and midwifery researchers, and were primarily designed to offer the beginning researcher a first-hand account of the experience of using particular methodologies.

  16. Framework for understanding the Strategic Defense Initiatives' software debates. Master's thesis

    SciTech Connect

    Adams, R.C.

    1990-06-01

    On March 23, 1983, then-President Ronald Reagan challenged a group of engineers and scientists to make nuclear weapons impotent and obsolete. This challenge led to the beginning of a new era in space technology and strategic defense, thus creating the Strategic Defense Initiative (SDI), better known as Star Wars. By 1984, several studies had begun to show that software in conjunction with Battle Management/Command, Control, and Communications techniques would play a major role in determining the effectiveness of the SDI. The results from these studies caused numerous controversial debates on the reliability, dependability, and trustworthiness of the software. This thesis provides a framework for understanding the complexities of the SDI software and points out some of the major issues involved in the software debates. The structure for this thesis is based on presenting the opinions of various computer scientists and engineers, indicating the issues that are controversial and those that have been defined as a necessity for the SDI program. One of the major highlights is the SDI summary chart that provides the reader with a very brief narrative of each individuals' opinion on the software issues discussed in this thesis.

  17. Science as an ally of religion: a Muslim appropriation of 'the conflict thesis'.

    PubMed

    Yalcinkaya, M Alper

    2011-06-01

    John W. Draper's History of the Conflict between Religion and Science (1874) is commonly regarded as the manifesto of the 'conflict thesis'. The superficiality of this thesis has been demonstrated in recent studies, but to read Draper's work only as a text on 'science versus religion' is to miss half of its significance, as it also involved evaluations of individual religions with respect to their attitudes towards science. Due to Draper's favourable remarks on Islam, the Ottoman author Ahmed Midhat translated his work into Turkish, and published it along with his own comments on Draper's arguments. Midhat interpreted Islam using the cues provided by Draper, and portrayed it as the only religion compatible with science. While his Christian readers condemned Draper for his approach to Islam, Midhat transformed the 'conflict thesis' into a proclamation that Islam and science were allies in opposition to Christian encroachment on the Ottoman Empire. This paper analyses Midhat's appropriation of Draper's work and compares it to the reaction of Draper's Christian readers. It discusses the context that made an alliance between Islam and science so desirable for Midhat, and emphasizes the impact of the historico-geographical context on the encounters between and representations of science and religion.

  18. Writing a bachelor thesis generates transferable knowledge and skills useable in nursing practice.

    PubMed

    Lundgren, Solveig M; Robertsson, Barbro

    2013-11-01

    Generic skills or transferable skills have been discussed in terms of whether or not skills learned in one context can be transferred into another context. The current study was aimed to explore nurses' self-perceptions of the knowledge and skills they had obtained while writing a Bachelor's thesis in nursing education, their experience of the extent of transfer and utilization in their current work. Responding nurses (N=42) had all worked from 1 to 1.5 years after their final examination and had completed a questionnaire that was structured with open-ended questions. Only five nurses reported that they were unable to use any of the knowledge and skills they had obtained from writing a thesis. A majority of the nurses (37/42) could give many examples of the practical application of the skills and knowledge they had obtained. Our findings indicate that writing a thesis as part of an undergraduate degree program plays a major role in the acquisition and development of knowledge and skills which can subsequently be transferred into and utilized in nursing practice.

  19. A numerical study of fundamental shock noise mechanisms. Ph.D. Thesis - Cornell Univ.

    NASA Technical Reports Server (NTRS)

    Meadows, Kristine R.

    1995-01-01

    The results of this thesis demonstrate that direct numerical simulation can predict sound generation in unsteady aerodynamic flows containing shock waves. Shock waves can be significant sources of sound in high speed jet flows, on helicopter blades, and in supersonic combustion inlets. Direct computation of sound permits the prediction of noise levels in the preliminary design stage and can be used as a tool to focus experimental studies, thereby reducing cost and increasing the probability of a successfully quiet product in less time. This thesis reveals and investigates two mechanisms fundamental to sound generation by shocked flows: shock motion and shock deformation. Shock motion is modeled by the interaction of a sound wave with a shock. During the interaction, the shock wave begins to move and the sound pressure is amplified as the wave passes through the shock. The numerical approach presented in this thesis is validated by the comparison of results obtained in a quasi-one dimensional simulation with linear theory. Analysis of the perturbation energy demonstrated for the first time that acoustic energy is generated by the interaction. Shock deformation is investigated by the numerical simulation of a ring vortex interacting with a shock. This interaction models the passage of turbulent structures through the shock wave. The simulation demonstrates that both acoustic waves and contact surfaces are generated downstream during the interaction. Analysis demonstrates that the acoustic wave spreads cylindrically, that the sound intensity is highly directional, and that the sound pressure level increases significantly with increasing shock strength. The effect of shock strength on sound pressure level is consistent with experimental observations of shock noise, indicating that the interaction of a ring vortex with a shock wave correctly models a dominant mechanism of shock noise generation.

  20. Modelling Legal Argument: Reasoning with Cases and Hypotheticals, a Thesis Proposal.

    DTIC Science & Technology

    1986-06-30

    gument. In Antonio A . Martino and Fiorenza Socci Natali, editors, Atti preliminari del II Convegno internazionale di studi su Logica Informat- ica...80-R175 925 MODELLING LEGAL RGUMENT: REASONING HITH CSSRO / HYPOTHETICALS A THESIS.. (U) MASSACHUSETTS UNIY AMHERST DEPT OF COMPUTER AND INFORMATION...S.. K D ASHLEY 7UNCLSSIFIED 3JUN6 CPT- N9914-5-K-0017 F/ /7 NL Ehhhmhhhmmmhhu EhhEEmhEmhEEEI mhsohmhmhEmhohE A bh9P I, ~4 4~I us9., ,~,4 V. %~j. ’S

  1. Top tips for PhD thesis examination: nurse clinicians, researchers and novices.

    PubMed

    Cleary, Michelle; Horsfall, Jan; Hunt, Glenn E

    2012-01-01

    Interestingly, there are very few guidelines in the literature to assist novice nurse PhD examiners. In this paper, we aim to provide information to nurses, researchers or early career academics who have little experience in assessing a university thesis. The article provides background information about recent changes in the university sector; overviews some research on experienced examiners views; presents factors that differentiate between high and low quality PhD theses; and outlines some pointers that may be useful when marking at the doctoral level.

  2. 7 CFR 3402.6 - Overview of the special international study and/or thesis/dissertation research travel allowance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... thesis/dissertation research travel allowance. 3402.6 Section 3402.6 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE...

  3. THE WEBER THESIS OF CALVINISM AND CAPITALISM--ITS VARIOUS VERSIONS AND THEIR "FATE" IN SOCIAL SCIENCE.

    PubMed

    Zafirovski, Milan

    2016-01-01

    The paper identifies and examines various multiple renditions of the so-called Weber Thesis of an historical association and convergence between ascetic Protestantism, above all Calvinism, and the emergence and development of modern capitalism as an economic spirit and system. Specifically, it detects at least four different versions and formulations or interpretations, thus casting doubt in the common view of the Weber Thesis as a single and monolithic theory or hypothesis. The paper also considers the status of the multiple versions of the Weber Thesis in post-Weberian and contemporary sociology and related disciplines like economics and history. It concludes that the weaker, relaxed renditions of the Weber Thesis have attained a greater success and more endured in contemporary social science than have its stronger, stricter versions.

  4. Intermediate design and analysis of the PANSAT electrical power subsystem. Master's thesis

    SciTech Connect

    Hand, G.F.

    1994-03-01

    This thesis examined three primary components of the electrical power subsystem (EPS) for the Petite Amateur Navy Satellite (PANSAT): (1) the solar array; (2) the power conditioning and control subsystem (PCCS); and (3) the batteries. The emphasis of this thesis was to analyze the output performance of the solar array. Additionally, the derivation of the hybrid PCCS proposed for the EPS was examined and the use of Nickel-Cadmium batteries as a candidate for the secondary power source was discussed. The investigation of the solar array's output performance led to PANSAM (PANSAT Solar Array Model), a computer model which simulates the power output of the solar array. The user can specify the sun's declination, the orbit's inclination, and the satellite's orientation and rate of rotation about each of its three axes. Once a simulation is complete, PANSAM provides the effective surface area illuminated by the sun, and the output current and power. The average effective area determined by PANSAM was 17.6% less than the 1259/sq cm originally proposed by the PANSAT staff. This contributed to a substantial reduction in predicted power. A preliminary transient thermal analysis of PANSAT was also conducted to provide temperature data for PANSAM.

  5. A doctoral thesis about Carol Davila written in Paris in 1936.

    PubMed

    Rogozea, Liliana; Dumitrascu, Dinu I; Triff, Dorin; Leasu, Florin; Dumitraşcu, Dan L

    2014-01-01

    Carol Davila, the father of the Romanian modern medicine, made decisive contributions to the development of health sciences in the Romanian Principalities in the last decades of the nineteenth century. The merit of his scientific work was recognized beyond the borders of his country. His life (not devoid of anecdotic instances and unknown episodes) and especially his work have aroused considerable interest among numerous medical historians. This paper presents a historical study elaborated in France, but until recently ignored, dedicated to the biography of Carol Davila. It concerns the medical doctoral thesis (State Diploma) elaborated by Joseph Adler (born 1910 in Botoşani, Romania) under the supervision of professor Maxime Laignel-Lavastine, whose interest in Romania is well-known. Professor Laignel-Lavastine held the office of Secretary General of the International Society of History of Medicine (ISHM), founded in 1921, (replaced in this position by another French professor with links to Romania: Jules Guiart). The thesis comprises 48 pages and an exhaustive bibliography. It represents a token of the appreciation given to Davila's achievements by Europe's medical community.

  6. A doctoral thesis about Carol Davila written in Paris in 1936

    PubMed Central

    ROGOZEA, LILIANA; DUMITRASCU, DINU I.; TRIFF, DORIN; LEASU, FLORIN; DUMITRAŞCU, DAN L.

    2014-01-01

    Carol Davila, the father of the Romanian modern medicine, made decisive contributions to the development of health sciences in the Romanian Principalities in the last decades of the nineteenth century. The merit of his scientific work was recognized beyond the borders of his country. His life (not devoid of anecdotic instances and unknown episodes) and especially his work have aroused considerable interest among numerous medical historians. This paper presents a historical study elaborated in France, but until recently ignored, dedicated to the biography of Carol Davila. It concerns the medical doctoral thesis (State Diploma) elaborated by Joseph Adler (born 1910 in Botoşani, Romania) under the supervision of professor Maxime Laignel-Lavastine, whose interest in Romania is well-known. Professor Laignel-Lavastine held the office of Secretary General of the International Society of History of Medicine (ISHM), founded in 1921, (replaced in this position by another French professor with links to Romania: Jules Guiart). The thesis comprises 48 pages and an exhaustive bibliography. It represents a token of the appreciation given to Davila’s achievements by Europe’s medical community. PMID:26527997

  7. [The thesis of judicialization of health care by the elites: medication for mucopolysaccharidosis].

    PubMed

    Medeiros, Marcelo; Diniz, Debora; Schwartz, Ida Vanessa Doederlein

    2013-04-01

    This paper evaluates the hypothesis that the judicialization of medicine for mucopolysaccharidosis in Brazil is an action promoted by economic elites. Previous studies upholding the thesis of judicialization by elites in the case of other types of medication that are more costly for the Unified Health Service are discussed. An analysis of all 196 processes containing information about judicial processes brought to court between February 2006 and December 2010 that ended by determining that the State should provide such medication free of charge to patients was conducted. There is evidence that attorneys' fees were covered by entities interested in the results of judicialization, such as the distributors or pharmaceutical industries. Patients may also be migrating for diagnosis and treatment to university centers that are a benchmark for medical innovation in the country, as the option for public health services is related to their higher technical and scientific capacity. Therefore, the resort to private lawyers, indicators of social exclusion based on the address of patients and the use of public health services, are not adequate class information to corroborate or refute the thesis of judicialization by the elites.

  8. Radiation and scattering from cylindrically conformal printed antennas. Ph.D. Thesis Final Report

    NASA Technical Reports Server (NTRS)

    Kempel, Leo C.; Volakis, John L.

    1994-01-01

    Microstrip patch antennas offer considerable advantages in terms of weight, aerodynamic drag, cost, flexibility, and observables over more conventional protruding antennas. These flat patch antennas were first proposed over thirty years ago by Deschamps in the United States and Gutton and Baisinot in France. Such antennas have been analyzed and developed for planar as well as curved platforms. However, the methods used in these designs employ gross approximations, suffer from extreme computational burden, or require expensive physical experiments. The goal of this thesis is to develop accurate and efficient numerical modeling techniques which represent actual antenna structures mounted on curved surfaces with a high degree of fidelity. In this thesis, the finite element method is extended to cavity-backed conformal antenna arrays embedded in a circular, metallic, infinite cylinder. Both the boundary integral and absorbing boundary mesh closure conditions will be used for terminating the mesh. These two approaches will be contrasted and used to study the scattering and radiation behavior of several useful antenna configurations. An important feature of this study will be to examine the effect of curvature and cavity size on the scattering and radiation properties of wraparound conformal antenna arrays.

  9. Indo-Pakistani nuclear issue: A US policy perspective. Master's thesis

    SciTech Connect

    Wolf, J.L.

    1992-06-01

    This thesis examines U.S. nonproliferation policy and the problem of nuclear proliferation in India and Pakistan. Its central hypothesis is that the end of the Cold War has created an opportunity to advance U.S. nonproliferation interests and work with both India and Pakistan to reduce the threat of a nuclear confrontation on the Indian Subcontinent. The thesis assesses both the motives for and the current status of the nuclear weapons programs in India and Pakistan. It also presents some plausible scenarios concerning future courses those programs could take. Finally, it presents a set of policy recommendations directed toward reducing Indo-Pakistani nuclear tensions and laying the foundations to make a future South Asian nuclear nonproliferation regime possible. Ultimately, this approach would create safer, more stable security arrangements for India and Pakistan and further reduce the threat from nuclear weapons in the post-Cold War world. United States, India, Pakistan, U.S.-Indian Relations, U.S.-Pakistan Relations, Nuclear Weapons, Nonproliferation, U.S. Foreign Policy.

  10. Environmental cost principle: Gone but not forgotten. Master`s thesis

    SciTech Connect

    Robb, J.L.

    1995-09-30

    This thesis has not focused on the myriad of environmental laws generating costs for government contractors. Compliance with such laws is not beyond the experience of government cost-reimbursement contracting. This thesis has not detailed the alternative to cost reimbursement; i.e., a contribution action against the United States for cleanup costs. Potential contribution action remains an issue when the contamination is related to the performance of a government contract. At the center of this analysis is the efficacy of the draft environmental cost principle. The draft cost principle forced the consideration of the many prickly issues that must someday be resolved. The draft cost principle is unlikely to return in present form. It may be gone, but it should not be forgotten. The environmental cost issues will resurface. Future attempts to address these issues will benefit from the careful consideration of the latest draft environmental cost principle. The core questions to be answered are what would be the impact of the cost principle on the treatment of various environmental costs, and whether such impact is for the good.

  11. Optimizing the post-START (Strategic Arms Reduction Treaty) US strategic nuclear force mix. Master's thesis

    SciTech Connect

    Leary, D.A.

    1989-06-01

    This thesis examines the impact a START agreement might have on the United States and Soviet strategic nuclear forces. It then proposes an optimum post-START force mix for the United States and the Soviet Union. The current, as well as projected, post-START targeting policies are discussed. It is concluded that the impact of a START agreement on the current U.S. strategic targeting policy will be minimal. Although the target data base will not shrink as much as the forces tasked to cover it, a prioritization of targets is all that should be necessary with a post-START force. A START agreement will mean major reductions in U.S. and Soviet strategic nuclear forces. As proposed in this thesis, only the ICBM leg of the Triad will require any major re-structuring. This would include the addition of mobile ICBM systems. The SLBM and bomber legs will feel minimal changes (i.e., retiring POSEIDON SSBNs and retiring or converting some older B-52s). It is recommended that the B-52 program be cancelled, and funding be re-directed into mobile ICBM systems. By doing so the United States could utilize technology available today to strengthen its forces and not gamble on the low-observable technology which a stealth bomber might have.

  12. Want to improve undergraduate thesis writing? Engage students and their faculty readers in scientific peer review.

    PubMed

    Reynolds, Julie A; Thompson, Robert J

    2011-01-01

    One of the best opportunities that undergraduates have to learn to write like a scientist is to write a thesis after participating in faculty-mentored undergraduate research. But developing writing skills doesn't happen automatically, and there are significant challenges associated with offering writing courses and with individualized mentoring. We present a hybrid model in which students have the structural support of a course plus the personalized benefits of working one-on-one with faculty. To optimize these one-on-one interactions, the course uses BioTAP, the Biology Thesis Assessment Protocol, to structure engagement in scientific peer review. By assessing theses written by students who took this course and comparable students who did not, we found that our approach not only improved student writing but also helped faculty members across the department--not only those teaching the course--to work more effectively and efficiently with student writers. Students who enrolled in this course were more likely to earn highest honors than students who only worked one-on-one with faculty. Further, students in the course scored significantly better on all higher-order writing and critical-thinking skills assessed.

  13. The absolute absorption cross section of crystalline αg and βg HNO33H2O (NAT) and HNO32H2O (NAD) in the range 180 - 200 K in the mid-IR (4000 to 600 cm-1)

    NASA Astrophysics Data System (ADS)

    Rossi, Michel J.; Iannarelli, Riccardo

    2014-05-01

    Heterogeneous processing in the polar atmosphere requires the presence of polar stratospheric cloud particles (PSC's) that are the seat of interfacial chlorine and NOx chemistry. A subgroup of PSC's, namely PSC Ia, are known to consist of hydrates of nitric acid, mostly nitric acid trihydrate (NAT) as two polymorphs, α- and β-HNO33H2O occurring in the range 185 to 200 K under prevailing stratospheric partial pressure conditions of 10 ppb HNO3 or so. Despite the fact that reference IR spectra in the mid-IR range have been obtained some time ago (Ritzhaupt and Devlin (1991), Koehler et al. (1992)), no absolute absorption cross section of these important ice particles exist to date except a study of its refractive indices (Middlebrook et al. (1994), Berland et al. (1994)). Knowledge of optical cross sections would enable remote sensing of PSC's in the IR region using satellite and/or LIDAR platforms. We have embarked on a multidiagnostic research program aiming at studying the kinetics, thermodynamics and spectroscopy of PSC's using a stirred flow reactor equipped with FTIR absorption spectroscopy in transmission. The gas phase was monitored using electron-impact residual gas mass spectroscopy together with pulsed and steady-state gas admission and thorough characterization of the adsorption of HNO3, H2O and HCl onto the stainless-steel vessel walls under mass balance conditions using measured Langmuir adsorption isotherms. We have grown α- and β-NAT by doping thin (1 μm thick) ice films with metered amounts of HNO3. According to known phase diagrams we have obtained mixtures of pure ice with NAT whose IR spectrum was obtained after spectral subtraction of the pure ice phase. The concentration of HNO3 deposited on the ice film was determined by measuring the inflow and taking into account adsorption of HNO3 on the reactor walls as well as effusive loss out the reactor. We also independently checked the H2O concentration of α-NAT from the decrease of the pure H2O

  14. [Albert Schweitzer's MD thesis on Criticism of the medical pathographies on Jesus].

    PubMed

    Seidel, Michael

    2009-01-01

    The prominent philosopher, theologian, physician, musicologist and organ soloist Albert Schweitzer (14. 1. 1875-4. 9. 1965) submitted his MD thesis Kritik der von medizinischer Seite veröffentlichten Pathographien uber Jesus (Criticism of the medical pathographies on Jesus) in 1913. Very soon he published this work under the title Die psychiatrische Beurteilung Jesu. Darstellung und Kritik (The psychiatric evaluation of Jesus. Description and criticism) in order to reach a broader audience. Schweitzer's explicit motive for selecting this topic was to influence the theological debate by means of a M. D. thesis on psychiatric pathographies on Jesus. He was confronted with a lot of reproaches. These reproaches contended that his theological opinions had been supporting tendencies to describe Jesus as a mentally ill person or a religious fanatic. In addition, some authors of pathographies on Jesus (De Loosten, Binet-Sanglé, Hirsch, Rasmussen) characterized Jesus as mentally ill, suffering from paranoia. Schweitzer intended to reject the reproaches considering himself and the postulates of the authors of the pathographies. Schweitzer combined in a transdisciplinary way theological, psychiatric and psychopathological arguments. He did this in a very convincing way. Although Schweitzer did not deal with a central or explicit psychiatric question, he implicitly postulated transdisciplinary approaches for proper retrospective pathographies on historic persons. At the age of thirty, Schweitzer decided to finish his academic career and to begin studies in medicine as a preparation for work as a physician in Africa. This decision provoked much lack of understanding in his personal environment. Therefore it may be possible that a very personal motive contributed to the selection of the topic of the MD thesis. Among psychiatric authorities, Albert Schweitzer's interest in the criticisms of psychiatric pathographies and his transdisciplinary approach to this topic encountered

  15. Exclusive studies of 130-270 MeV {sup 3}He- and 200-MeV proton-induced reactions on {sup 27}Al, {sup nat}Ag, and {sup 197}Au

    SciTech Connect

    Ginger, D. S.; Kwiatkowski, K.; Wang, G.; Hsi, W.-C.; Hudan, S.; Cornell, E.; Souza, R. T. de; Viola, V. E.; Korteling, R. G.

    2008-09-15

    Exclusive light-charged-particle and IMF spectra have been measured with the ISiS detector array for bombardments of {sup 27}Al, {sup nat}Ag, and {sup 197}Au nuclei with 130-270-MeV {sup 3}He and 200-MeV protons. The results are consistent with previous interpretations based on inclusive data that describe the global yield of complex fragments in terms of a time-dependent process. The emission mechanism for energetic nonequilibrium fragments observed at forward angles with momenta up to twice the beam momentum is also investigated. This poorly understood mechanism, for which the angular distributions indicate formation on a time scale comparable to the nuclear transit time, are accompanied primarily by thermal-like emissions. The data are most consistent with a schematic picture in which nonequilibrium fragments are formed in a localized region of the target nucleus at an early stage in the energy-dissipation process, where the combined effects of high energy density and Fermi motion produce the observed suprathermal spectra.

  16. NO3- Coordination in Aqueous Solutions by 15N/14N and 18O/natO Isotopic Substitution: What Can We Learn from Molecular Simulation?

    SciTech Connect

    Chialvo, Ariel A.; Vlcek, Lukas

    2014-12-16

    We explore the deconvolution of the water-nitrate correlations by the first-order difference approach involving neutron diffraction of heavy- and null-aqueous solutions of KNO3 under 14N 15N and natON 18ON substitutions to achieve a full characterization of the first water coordination around the nitrate ion. For that purpose we performed isobaric-isothermal simulations of 3.5m KNO3 aqueous solutions at ambient conditions to generate the relevant radial distribution functions (RDF) required in the analysis (a) to identify the individual partial contributions to the total neutron weighted distribution function, (b) to isolate and assess the contribution of NO3 -!K+ pair formation, (c) to test the accuracy of the NDIS-based coordination calculations and XRDbased assumptions, and (d) to describe the water coordination around both the nitrogen and oxygen sites of the nitrate ion.

  17. Measurements of production cross sections of 10Be and 26Al by 120 GeV and 392 MeV proton bombardment of 89Y, 159Tb, and natCu targets

    NASA Astrophysics Data System (ADS)

    Sekimoto, S.; Okumura, S.; Yashima, H.; Matsushi, Y.; Matsuzaki, H.; Matsumura, H.; Toyoda, A.; Oishi, K.; Matsuda, N.; Kasugai, Y.; Sakamoto, Y.; Nakashima, H.; Boehnlein, D.; Coleman, R.; Lauten, G.; Leveling, A.; Mokhov, N.; Ramberg, E.; Soha, A.; Vaziri, K.; Ninomiya, K.; Omoto, T.; Shima, T.; Takahashi, N.; Shinohara, A.; Caffee, M. W.; Welten, K. C.; Nishiizumi, K.; Shibata, S.; Ohtsuki, T.

    2015-10-01

    The production cross sections of 10Be and 26Al were measured by accelerator mass spectrometry using 89Y, 159Tb, and natCu targets bombarded by protons with energies Ep of 120 GeV and 392 MeV. The production cross sections obtained for 10Be and 26Al were compared with those previously reported using Ep = 50 MeV-24 GeV and various targets. It was found that the production cross sections of 10Be monotonically increased with increasing target mass number when the proton energy was greater than a few GeV. On the other hand, it was also found that the production cross sections of 10Be decreased as the target mass number increased from that of carbon to those near the mass numbers of nickel and zinc when the proton energy was below approximately 1 GeV. They also increased as the target mass number increased from near those of nickel and zinc to that of bismuth, in the same proton energy range. Similar results were observed in the production cross sections of 26Al, though the absolute values were quite different between 10Be and 26Al. The difference between these production cross sections may depend on the impact parameter (nuclear radius) and/or the target nucleus stiffness.

  18. Experimental cross-sections of deuteron-induced reaction on 89Y up to 20 MeV; comparison of natTi(d,x)48V and 27Al(d,x)24Na monitor reactions

    NASA Astrophysics Data System (ADS)

    Lebeda, Ondřej; Štursa, Jan; Ráliš, Jan

    2015-10-01

    We measured cross-sections of the deuteron-induced reactions on 89Y in the energy range of 3.9-19.5 MeV. Excitation functions for formation of 88Zr, 89mZr, 89Zr, 88Y, 90mY and 87mSr were determined and compared with previously published data and prediction of the TALYS code. Thick target yields for production of 88Zr, 89Zrcum, 88Y, 90mY and 87mSr were calculated from the measured cross-sections. Achievable activity versus radionuclidic purity of medically relevant 89Zr is discussed and compared with the production via the 89Y(p,n) reaction. Parallel use of titanium and aluminium beam monitors revealed systematic difference between the recommended cross-sections of both monitoring reactions and provided new cross-section data for formation of 24Na, 27Mg, 43Sc, 44mSc, 44Sc, 46Sc, 47Sc and 48Sc. The cross-sections for the natTi(d,x)46Sc reactions agree very well with recently proposed recommended values.

  19. Measurements of production cross sections of 10Be and 26Al by 120 GeV and 392 MeV proton bombardment of 89Y, 159Tb, and natCu targets

    DOE PAGES

    Sekimoto, S.; Okumura, S.; Yashima, H.; ...

    2015-08-12

    The production cross sections of 10Be and 26Al were measured by accelerator mass spectrometry using 89Y, 159Tb, and natCu targets bombarded by protons with energies Ep of 120 GeV and 392 MeV. The production cross sections obtained for 10Be and 26Al were compared with those previously reported using Ep = 50 MeV–24 GeV and various targets. It was found that the production cross sections of 10Be monotonically increased with increasing target mass number when the proton energy was greater than a few GeV. On the other hand, it was also found that the production cross sections of 10Be decreased asmore » the target mass number increased from that of carbon to those near the mass numbers of nickel and zinc when the proton energy was below approximately 1 GeV. They also increased as the target mass number increased from near those of nickel and zinc to that of bismuth, in the same proton energy range. Similar results were observed in the production cross sections of 26Al, though the absolute values were quite different between 10Be and 26Al. As a result, the difference between these production cross sections may depend on the impact parameter (nuclear radius) and/or the target nucleus stiffness.« less

  20. Dependability analysis of parallel systems using a simulation-based approach. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Sawyer, Darren Charles

    1994-01-01

    The analysis of dependability in large, complex, parallel systems executing real applications or workloads is examined in this thesis. To effectively demonstrate the wide range of dependability problems that can be analyzed through simulation, the analysis of three case studies is presented. For each case, the organization of the simulation model used is outlined, and the results from simulated fault injection experiments are explained, showing the usefulness of this method in dependability modeling of large parallel systems. The simulation models are constructed using DEPEND and C++. Where possible, methods to increase dependability are derived from the experimental results. Another interesting facet of all three cases is the presence of some kind of workload of application executing in the simulation while faults are injected. This provides a completely new dimension to this type of study, not possible to model accurately with analytical approaches.

  1. Decision support system for control and automation of dynamical processes. Master's thesis

    SciTech Connect

    Nann, S.

    1990-03-01

    The thesis presents the concept and development of a diagnostic decision support system for real-time control and automation of dynamic processes. This system, known as DECA (Diagnostic Evaluation and Corrective Action), will take advantage of the computer's ability to manipulate vast amounts of data, and employ qualitative reasoning for the monitoring and diagnosis of dynamical processes during time-constrained, routine, and emergency situations where an immediate response is necessary to avoid catastrophic failure of the system. The software system's architecture has been structured in such a manner that is can be applied to any dynamic process without reprogramming. DECA is written in Lisp and was verified using the data from the Three Mile Island Nuclear Reactor Accident.

  2. Analysis of the asbestos permissible-exposure-level threshold standard. Master's thesis

    SciTech Connect

    Peterson, M.W.

    1991-06-01

    This thesis examines the reasoning of the Occupational Safety and Health Administration's (OSHA) decision to set stringent exposure levels for airborne asbestos in the work place. Technical recommendations from the National Institute for Occupational Safety and Health (NIOSH), the Bureau of Mines, and the American conference of Governmental Industrial Hygienists were presented to OSHA for consideration. OSHA and the Environmental Protection Agency (EPA) set industry standards for permissible exposure levels (PEL) of airborne asbestos. Exposure to asbestos poses a health hazard to workers, their families, and consumers of asbestos products. Because it poses an unreasonable risk human life, OSHA has repeatedly lowered the Permissible Exposure Levels and the EPA will ban the manufacture, importation, processing and commercial distribution of asbestos containing products from the United States in phases by 1997. These decisions may have been made too hastily because of the long latency (15-40 years) period before cancer develops, and the added risks that smoking imposes.

  3. Origin and evolution of US Naval strategic nuclear policy to 1960. Master's thesis

    SciTech Connect

    Kreitlein, H.C.

    1986-12-01

    This thesis treats the impact of the atomic bomb on traditional naval strategy as that strategy had developed under the influence of Captain Alfred T. Mahan, how traditional naval strategy was modified by the development of naval aviation, the lessons of World War II, and the leadership of James Forrestal, and how the adoption of atomic weapons into naval strategic planning was integrally tied to naval aviation. The growth of the Soviet Union as a threat to world peace, and interservice rivalry over roles and missions are compared as factors that influenced the development of post-World War II naval strategic thinking. The Navy's reaction to the adoption of massive retaliation as the foundation of the national strategic nuclear policy is discussed and analyzed.

  4. An analytical relationship between the magnetospheric potential drop and the ionospheric conductance. Ph.D. Thesis

    SciTech Connect

    Krisko, P.H.

    1994-01-01

    In this thesis the author derives an analytical relationship between the Earth`s magnetospheric potential drop and the ionospheric conductance by adopting a simple two-dimensional model of a magnetic field draping around the tail magnetopause. Two methods are used: (1) matching currents through the tail magnetopause and the Earth`s ionosphere in analogy with the Alfven wing at the Jovian satellite, Io; and (2) minimizing the total power that the solar wind loses to the Earth`s magnetosphere. The author finds, in both cases, the magnetospheric conductance, Sigma(sub is), and compares this result to the revised result of the numerical model of Fedder and Lyon and to the conclusions of Hill et al. and Hill. Considering the derived proportionality factor as a `magnetosheath conductance`, Sigma(sub msh), the author determines that the high-latitude tail magnetospheric `driver` acts as a current generator as opposed to a voltage generator.

  5. A matrix safety frame approach to robot safety for space applications. Thesis

    NASA Technical Reports Server (NTRS)

    Montgomery, T. D.; Lauderbaugh, L. Ken

    1988-01-01

    The planned use of autonomous robots in space applications has generated many new safety problems. This thesis assesses safety of autonomous robot systems through the structure of a proposed three-dimensional matrix safety frame. By identifying the common points of accidents and fatalities involving terrestrial robots, reviewing terrestrial robot safety standards, and modifying and extending these results to space applications, hazards are identified and their associated risks assessed. Three components of the safeguarding dimension of the matrix safety frame, safeguarding through design and operation for intrinsic safety, and incorporation of add-on safety systems are explained through examples for both terrestrial and space robots. A space robot hazard identification checklist, a qualitative tool for robot systems designers, is developed using the structure imparted by the matrix safety frame. The development of an expert system from the contents of the checklist is discussed.

  6. A thesis on the Development of an Automated SWIFT Edge Detection Algorithm

    SciTech Connect

    Trujillo, Christopher J.

    2016-07-28

    Throughout the world, scientists and engineers such as those at Los Alamos National Laboratory, perform research and testing unique only to applications aimed towards advancing technology, and understanding the nature of materials. With this testing, comes a need for advanced methods of data acquisition and most importantly, a means of analyzing and extracting the necessary information from such acquired data. In this thesis, I aim to produce an automated method implementing advanced image processing techniques and tools to analyze SWIFT image datasets for Detonator Technology at Los Alamos National Laboratory. Such an effective method for edge detection and point extraction can prove to be advantageous in analyzing such unique datasets and provide for consistency in producing results.

  7. Quantification for complex assessment: uncertainty estimation in final year project thesis assessment

    NASA Astrophysics Data System (ADS)

    Kim, Ho Sung

    2013-12-01

    A quantitative method for estimating an expected uncertainty (reliability and validity) in assessment results arising from the relativity between four variables, viz examiner's expertise, examinee's expertise achieved, assessment task difficulty and examinee's performance, was developed for the complex assessment applicable to final year project thesis assessment including peer assessment. A guide map can be generated by the method for finding expected uncertainties prior to the assessment implementation with a given set of variables. It employs a scale for visualisation of expertise levels, derivation of which is based on quantified clarities of mental images for levels of the examiner's expertise and the examinee's expertise achieved. To identify the relevant expertise areas that depend on the complexity in assessment format, a graphical continuum model was developed. The continuum model consists of assessment task, assessment standards and criterion for the transition towards the complex assessment owing to the relativity between implicitness and explicitness and is capable of identifying areas of expertise required for scale development.

  8. Evidence, illness, and causation: an epidemiological perspective on the Russo-Williamson Thesis.

    PubMed

    Fiorentino, Alexander R; Dammann, Olaf

    2015-12-01

    According to the Russo-Williamson Thesis, causal claims in the health sciences need to be supported by both difference-making and mechanistic evidence. In this article, we attempt to determine whether Evidence-based Medicine (EBM) can be improved through the consideration of mechanistic evidence. We discuss the practical composition and function of each RWT evidence type and propose that exposure-outcome evidence (previously known as difference-making evidence) provides associations that can be explained through a hypothesis of causation, while mechanistic evidence provides finer-grained associations and knowledge of entities that ultimately explains a causal hypothesis. We suggest that mechanistic evidence holds untapped potential to add value to the assessment of evidence quality in EBM and propose initial recommendations for the integration of mechanistic and exposure-outcome evidence to improve EBM by robustly leveraging available evidence in support of good medical decisions.

  9. On Engster's care-justification of the specialness thesis about healthcare.

    PubMed

    Rumbold, Benedict

    2016-06-07

    To say health is 'special' is to say that it has a moral significance that differentiates it from other goods (cars, say or radios) and, as a matter of justice, warrants distributing it separately. In this essay, I critique a new justification for the specialness thesis about healthcare (STHC) recently put forth by Engster. I argue that, regrettably, Engster's justification of STHC ultimately fails and fails on much the same grounds as have previous justifications of STHC. However, I also argue that Engster's argument still adds something valuable to the debate around STHC insofar as it reminds us that the moral significance of healthcare may be wider than simply its effect on the incidence of disability and disease: one further reason we may think healthcare is morally significant is because it concerns the treatment and care of those who are already unwell.

  10. Why evidence-based medicine is a good approach in physical and rehabilitation medicine. Thesis.

    PubMed

    Negrini, S

    2014-10-01

    According to a good definition, evidence-based medicine (EBM) is: "The explicit, conscientious, and judicious use of the current best evidence in making decisions about the care of individual patients (and populations)". More appropriate in a clinical context like that of physical and rehabilitation medicine (PRM) is looking at evidence based clinical practice (EBCP), whose definition is: "The integration of best research evidence with clinical expertise and patient values". In the past the term evidence-based physical and rehabilitation medicine (EBPRM) was also proposed. In this thesis, after some historical notes on EBM and on PRM, we will discuss why in our view EBPRM must be the real foundation of our everyday PRM clinical practice.

  11. Deep venous thrombosis: The valve cusp hypoxia thesis and its incompatibility with modern orthodoxy.

    PubMed

    Malone, P Colm; Agutter, Paul S

    2016-01-01

    The valve cusp hypoxia thesis (VCHT) of the aetiology of deep venous thrombosis (DVT) was adumbrated in this journal in 1977 and fully articulated in 2008, the original hypothesis having been strongly corroborated by experiments published in 1981 and 1984. It presents a unitary account of the pathogenesis of venous thrombosis and embolism that is rooted in the pathophysiological tradition of Hunter, Virchow, Lister, Welch and Aschoff, a tradition traceable back to Harvey. In this paper we summarise the thesis in its mature form, consider its compatibility with recent advances in the DVT field, and ask why it has not yet been assimilated into the mainstream literature, which during the past half century has been dominated by a haematology-orientated 'consensus model'. We identify and discuss seven ways in which the VCHT is incompatible with these mainstream beliefs about the aetiology of venous thrombosis, drawing attention to: (1) the spurious nature of 'Virchow's triad'; (2) the crucial differences between 'venous thrombus' and 'clot'; the facts that (3) venous thrombi form in the valve pockets (VVPs), (4) DVT is not a primarily haematological condition, (5) the so-called 'thrombophilias' are not thrombogenic per se; (6) the conflict between the single unitary aetiology of DVT and the tacit assumption that the condition is 'multicausal'; (7) the inability of anticoagulants to prevent the initiation of venous thrombogenesis, though they do prevent the growth of thrombi to clinically significant size. In discussing point (7), we show that the VCHT indicates new approaches to mechanical prophylaxis against DVT. These approaches are then formulated as experimentally testable hypotheses, and we suggest methods for testing them preclinically using animal trials.

  12. [Historical studies and medicine. A study in Swedish doctoral thesis concerning history of medicine 1970-2004].

    PubMed

    Qvarsell, Roger

    2006-01-01

    This article is a study in ninety doctoral thesis published in Sweden between 1970 and 2004 concerning history of the science of medicine and hospital care, patients and practicioners, causes of death and public health, doctors and nurses, health movements and lay medicine and other aspects of the history of medicine. A quantitative part of the study shows that most thesis have been written at departments of history or history of ideas, but sociological and mulitdisciplinary studies are also rather common. Only six of the thesis have been written at departments within the medical faculties. The second half of the 19th and the first half of the 20th centuries has been investigated more often than other historical periods. More than ninety percent of the thesis has been published in Swedish and concerns history of medicine in Sweden. A wide range of methods and theories has been used and history of medicine does not as a field deviate from historical research in general in this respect. A chronological bibliography of the ninety thesis ends the article.

  13. Nursing students' attitudes toward research and development within nursing: Does writing a bachelor thesis make a difference?

    PubMed

    Uysal Toraman, Aynur; Hamaratçılar, Güler; Tülü, Begüm; Erkin, Özüm

    2017-01-16

    The aim of this study was to investigate the effect of writing a bachelor's thesis on nursing students' attitudes towards research and development in nursing. The study sample consisted of 91 nursing students who were required to complete a bachelor's thesis and 89 nursing students who were not required to complete a bachelor's thesis. Data were collected via self-report questionnaire that was distributed in May and June 2012. The questionnaire comprised 3 parts: (1) demographic items; (2) questions about "scientific activities," and (3) the nursing students' attitudes towards and awareness of research and development within nursing scale (version 2). The mean age of the students was 23 (1.3) years. The students who wrote a bachelor's thesis achieved a median score of 110.0, whereas the students in the other group had a median score of 105.0 on the scale. All the items were assigned a 3 or higher. A statistically significant difference was found between the 2 groups in their attitudes towards and awareness of research (U = 3265.5; P = .025). The results of this study suggest that writing a thesis in nursing education has a positive influence on nursing students' attitudes towards and awareness of research and development in nursing.

  14. The mid-IR Absorption Cross Sections of α- and β-NAT (HNO3 · 3H2O) in the range 170 to 185 K and of metastable NAD (HNO3 · 2H2O) in the range 172 to 182 K

    NASA Astrophysics Data System (ADS)

    Iannarelli, R.; Rossi, M. J.

    2015-11-01

    Growth and Fourier transform infrared (FTIR) absorption in transmission of the title nitric acid hydrates have been performed in a stirred flow reactor (SFR) under tight control of the H2O and HNO3 deposition conditions affording a closed mass balance of the binary mixture. The gas and condensed phases have been simultaneously monitored using residual gas mass spectrometry and FTIR absorption spectroscopy, respectively. Barrierless nucleation of the metastable phases of both α-NAT (nitric acid trihydrate) and NAD (nitric acid dihydrate) has been observed when HNO3 was admitted to the SFR in the presence of a macroscopic thin film of pure H2O ice of typically 1 µm thickness. The stable β-NAT phase was spontaneously formed from the precursor α-NAT phase through irreversible thermal rearrangement beginning at 185 K. This facile growth scheme of nitric acid hydrates requires the presence of H2O ice at thicknesses in excess of approximately hundred nanometers. Absolute absorption cross sections in the mid-IR spectral range (700-4000 cm-1) of all three title compounds have been obtained after spectral subtraction of excess pure ice at temperatures characteristic of the upper troposphere/lower stratosphere. Prominent IR absorption frequencies correspond to the antisymmetric nitrate stretch vibration (ν3(NO3-)) in the range 1300 to 1420 cm-1 and the bands of hydrated protons in the range 1670 to 1850 cm-1 in addition to the antisymmetric O-H stretch vibration of bound H2O in the range 3380 to 3430 cm-1 for NAT.

  15. Preliminary design of the PANSAT electrical-power subsystem. Master's thesis

    SciTech Connect

    Noble, M.L.

    1990-06-01

    This thesis presents a preliminary design of the electrical power system (EPS) for the Naval Postgraduate School's Petite Amateur Navy Satellite (PANSAT). The EPS is a photovoltaic silicon cell system consisting of solar array, batteries, battery charge regulator (BCR), and dc-dc convertors. The EPS provides power for up to two years of low earth orbit (480 km) operations. The solar array consists of 17 panels with thirty-two 2 {times} 4 cm solar cells in series on each panel. The cells have an efficiency of 14.3% and generate a panel voltage of 14.1 volts at beginning of life, providing an unregulated bus voltage of 13.5 volts. The bus voltage is clamped at a minimum 10.5 volts by two lead acid batteries in parallel with the bus. Each battery consists of five 2.1 volt, 5 ampere-hour lead acid cells and is capable of meeting mission requirements. The BCR monitors individual battery voltage, an indication of reserve capacity, and provides a pulse-modulated charge current alternately to each battery.

  16. Preliminary development of a nuclear propulsion officer enlistment supply model. Master's thesis

    SciTech Connect

    Serfass, P.T.

    1986-09-01

    This study constructs linear forecasting models, for each of the six Navy Recruiting Areas and the Recruiting Command, that attempt to predict future United States Navy Nuclear Propulsion Officer contracts signed in any one of four fiscal year quarters, given estimates of independent supply variables included in the models. The models are developed using stepwise multiple regression analysis with ordinary least squares and are supported by historical data from fiscal years 1981 through 1985. In developing the models, the thesis examines the relationship between the contracts signed in a given quarter and the following supply variables: number of recruiters, annual goals of number of contracts to be signed, military-to-civilian pay ratio, unemployment rate, size of target population (in the form of market share), advertising and marketing costs and seasonal effects, represented by proxy variables. The assumptions of using multiple regression analysis and linear models are examined through a graphical study of the residuals and do not seem to be refuted. Each of the models are corrected for first order autocorrelation. Validation of the forecasting models was attempted by the comparison of predicted contracts signed in a quarter against new contract data obtained for fiscal year 1986. The results of the forecasting comparisons are much worse than expected. Possible causes for the large error percentages in the comparisons are mentioned in this study but not examined in detail.

  17. Conic Sector Analysis of Hybrid Control Systems. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Thompson, P. M.

    1982-01-01

    A hybrid control system contains an analog plant and a hybrid (or sampled-data) compensator. In this thesis a new conic sector is determined which is constructive and can be used to: (1) determine closed loop stability, (2) analyze robustness with respect to modelling uncertainties, (3) analyze steady state response to commands, and (4) select the sample rate. The use of conic sectors allows the designer to treat hybrid control systems as though they were analog control systems. The center of the conic sector can be used as a rigorous linear time invariant approximation of the hybrid control system, and the radius places a bound on the errors of this approximation. The hybrid feedback system can be multivariable, and the sampler is assumed to be synchronous. Algorithms to compute the conic sector are presented. Several examples demonstrate how the conic sector analysis techniques are applied. Extensions to single loop multirate hybrid feedback systems are presented. Further extensions are proposed for multiloop multirate hybrid feedback system and for single rate systems with asynchronous sampling.

  18. Fluid flow and sound generation at hydrothermal vent fields. Doctoral thesis

    SciTech Connect

    Little, S.A.

    1988-04-01

    Several experiments in this thesis examine methods to measure and monitor fluid flow from hydrothermal vent fields. Simultaneous velocity temperature, and conductivity data were collected in the convective flow emanating from a hydrothermal vent field located on the East Pacific rise. The horizontal profiles obtained indicate that the flow field approaches an ideal plume in the temperature and velocity distribution. Such parameters as total heat flow and maximum plume height can be estimated using either the velocity or the temperature information. The results of these independent calculations are in close agreement, yielding a total heat capacity and volume changes slightly alter the calculations applied to obtain these values. In Guaymas Basin, a twelve day time series of temperature data was collected from a point three centimeters above a diffuse hydrothermal flow area. Using concurrent tidal gauge data from the town of Guaymas it is shown that the effects of tidal currents can be strong enough to dominate the time variability of a temperature signal at a fixed point in hydrothermal flow and are a plausible explanation for the variations seen in the Guaymas Basin temperature data. The increase in power due to convected flow inhomogeneities, however, was lower in the near field than expected. Indirect evidence of hydrothermal sound fields showing anomalous high power and low frequency noise associated with vents is due to processes other than jet noise.

  19. Error modeling for differential GPS. M.S. Thesis - MIT, 12 May 1995

    NASA Technical Reports Server (NTRS)

    Blerman, Gregory S.

    1995-01-01

    Differential Global Positioning System (DGPS) positioning is used to accurately locate a GPS receiver based upon the well-known position of a reference site. In utilizing this technique, several error sources contribute to position inaccuracy. This thesis investigates the error in DGPS operation and attempts to develop a statistical model for the behavior of this error. The model for DGPS error is developed using GPS data collected by Draper Laboratory. The Marquardt method for nonlinear curve-fitting is used to find the parameters of a first order Markov process that models the average errors from the collected data. The results show that a first order Markov process can be used to model the DGPS error as a function of baseline distance and time delay. The model's time correlation constant is 3847.1 seconds (1.07 hours) for the mean square error. The distance correlation constant is 122.8 kilometers. The total process variance for the DGPS model is 3.73 sq meters.

  20. Coded throughput performance simulations for the time-varying satellite channel. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Han, LI

    1995-01-01

    The design of a reliable satellite communication link involving the data transfer from a small, low-orbit satellite to a ground station, but through a geostationary satellite, was examined. In such a scenario, the received signal power to noise density ratio increases as the transmitting low-orbit satellite comes into view, and then decreases as it then departs, resulting in a short-duration, time-varying communication link. The optimal values of the small satellite antenna beamwidth, signaling rate, modulation scheme and the theoretical link throughput (in bits per day) have been determined. The goal of this thesis is to choose a practical coding scheme which maximizes the daily link throughput while satisfying a prescribed probability of error requirement. We examine the throughput of both fixed rate and variable rate concatenated forward error correction (FEC) coding schemes for the additive white Gaussian noise (AWGN) channel, and then examine the effect of radio frequency interference (RFI) on the best coding scheme among them. Interleaving is used to mitigate degradation due to RFI. It was found that the variable rate concatenated coding scheme could achieve 74 percent of the theoretical throughput, equivalent to 1.11 Gbits/day based on the cutoff rate R(sub 0). For comparison, 87 percent is achievable for AWGN-only case.

  1. Empirical evaluation of analytical models for parallel relational data-base queries. Master's thesis

    SciTech Connect

    Denham, M.C.

    1990-12-01

    This thesis documents the design and implementation of three parallel join algorithms to be used in the verification of analytical models developed by Kearns. Kearns developed a set of analytical models for a variety of relational database queries. These models serve as tools for the design of parallel relational database system. Each of Kearns' models is classified as either single step or multiple step. The single step models reflect queries that require only one operation while the multiple step models reflect queries that require multiple operations. Three parallel join algorithms were implemented based upon Kearns' models. Two are based upon single step join models and one is based upon a multiple step join model. They are implemented on an Intel iPSC/1 parallel computer. The single step join algorithms include the parallel nested-loop join and the bucket (or hash) join. The multiple step algorithm that was implemented is a pipelined version of the bucket join. The results show that within the constraints of the test cases run, the three models are all at least accurate to within about 8.5% and they should prove useful in the design of parallel relational database systems.

  2. Strategic culture and ballistic missile defense: Russia and the United States. Master's thesis

    SciTech Connect

    Becker, M.D.

    1993-06-01

    This thesis examines U.S. and Russian history and current policy debates to advance understanding of: (1) the strategic cultures of these nations, particularly with respect to BMD policies in the recent past; and (2) whether and how their strategic cultures and approaches to BMD are changing and how that may affect future strategic BMD developments and the status of the ABM Treaty. The development of BMD strategies, including policies concerning the ABM Treaty, within the framework of the established American and Russian strategic cultures is studied, with due attention to the Soviet experience and legacy in the Russian case. U.S. strategic culture does not seem to have changed significantly with the end of the Cold War, but U.S. BMD priorities have been redefined to reflect a higher priority attached to regional and theater-level defenses. It is apparent that the Soviet experience did have a significant impact on Russian strategic culture. Faced with major changes in its international status, domestic political-military arrangements, and scope of national security concerns, Russian strategic culture is nonetheless moving beyond the old Soviet culture. Future Russian policies regarding the transfer of BMD technology, sharing early warning data, and participating in a global protective system are heavily dependent on domestic political developments. United States, Russia, USSR, Strategic culture, Ballistic missile defense, National strategy, Nuclear strategy, Strategic defense, ABM Treaty, Arms control, Strategic stability.

  3. Two nonlinear models of the free-electron laser. Master's thesis

    SciTech Connect

    Kiel, D.H.

    1990-11-01

    The dynamics of the Free Electron Laser are governed by Maxwell's equations which causes many highly nonlinear regimes to exist in Free Electron Laser Physics. This thesis will examine two such areas and develop simple models to describe the highly dynamic and rich behavior two of these regimes. In the strong-field, high current regime, the Free Electron Laser driving current can be modeled by a single macroparticle representing the trapped electrons. When the trapped electrons act collectively as a macroparticle, solutions which include synchrotron oscillations can be found for the self-consistent pendulum and wave equations. In an FEL oscillator with low single-pass gain, the evolution of the optical wave can lead to sideband development. This phenomenon is studied by applying Maxwell's equations to an oscillator with two optical modes and deriving a two-mode wave and pendulum equation. The two-mode wave and pendulum equations are implemented numerically on computers so that the onset of the sideband can be explored.

  4. Space-Bounded Church-Turing Thesis and Computational Tractability of Closed Systems.

    PubMed

    Braverman, Mark; Schneider, Jonathan; Rojas, Cristóbal

    2015-08-28

    We report a new limitation on the ability of physical systems to perform computation-one that is based on generalizing the notion of memory, or storage space, available to the system to perform the computation. Roughly, we define memory as the maximal amount of information that the evolving system can carry from one instant to the next. We show that memory is a limiting factor in computation even in lieu of any time limitations on the evolving system-such as when considering its equilibrium regime. We call this limitation the space-bounded Church-Turing thesis (SBCT). The SBCT is supported by a simulation assertion (SA), which states that predicting the long-term behavior of bounded-memory systems is computationally tractable. In particular, one corollary of SA is an explicit bound on the computational hardness of the long-term behavior of a discrete-time finite-dimensional dynamical system that is affected by noise. We prove such a bound explicitly.

  5. Robust control design with real parameter uncertainty using absolute stability theory. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    How, Jonathan P.; Hall, Steven R.

    1993-01-01

    The purpose of this thesis is to investigate an extension of mu theory for robust control design by considering systems with linear and nonlinear real parameter uncertainties. In the process, explicit connections are made between mixed mu and absolute stability theory. In particular, it is shown that the upper bounds for mixed mu are a generalization of results from absolute stability theory. Both state space and frequency domain criteria are developed for several nonlinearities and stability multipliers using the wealth of literature on absolute stability theory and the concepts of supply rates and storage functions. The state space conditions are expressed in terms of Riccati equations and parameter-dependent Lyapunov functions. For controller synthesis, these stability conditions are used to form an overbound of the H2 performance objective. A geometric interpretation of the equivalent frequency domain criteria in terms of off-axis circles clarifies the important role of the multiplier and shows that both the magnitude and phase of the uncertainty are considered. A numerical algorithm is developed to design robust controllers that minimize the bound on an H2 cost functional and satisfy an analysis test based on the Popov stability multiplier. The controller and multiplier coefficients are optimized simultaneously, which avoids the iteration and curve-fitting procedures required by the D-K procedure of mu synthesis. Several benchmark problems and experiments on the Middeck Active Control Experiment at M.I.T. demonstrate that these controllers achieve good robust performance and guaranteed stability bounds.

  6. Investigation of finite element: ABC methods for electromagnetic field simulation. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Chatterjee, A.; Volakis, John L.; Nguyen, J.

    1994-01-01

    The mechanics of wave propagation in the presence of obstacles is of great interest in many branches of engineering and applied mathematics like electromagnetics, fluid dynamics, geophysics, seismology, etc. Such problems can be broadly classified into two categories: the bounded domain or the closed problem and the unbounded domain or the open problem. Analytical techniques have been derived for the simpler problems; however, the need to model complicated geometrical features, complex material coatings and fillings, and to adapt the model to changing design parameters have inevitably tilted the balance in favor of numerical techniques. The modeling of closed problems presents difficulties primarily in proper meshing of the interior region. However, problems in unbounded domains pose a unique challenge to computation, since the exterior region is inappropriate for direct implementation of numerical techniques. A large number of solutions have been proposed but only a few have stood the test of time and experiment. The goal of this thesis is to develop an efficient and reliable partial differential equation technique to model large three dimensional scattering problems in electromagnetics.

  7. Design for dependability: A simulation-based approach. Ph.D. Thesis, 1993

    NASA Technical Reports Server (NTRS)

    Goswami, Kumar K.

    1994-01-01

    This research addresses issues in simulation-based system level dependability analysis of fault-tolerant computer systems. The issues and difficulties of providing a general simulation-based approach for system level analysis are discussed and a methodology that address and tackle these issues is presented. The proposed methodology is designed to permit the study of a wide variety of architectures under various fault conditions. It permits detailed functional modeling of architectural features such as sparing policies, repair schemes, routing algorithms as well as other fault-tolerant mechanisms, and it allows the execution of actual application software. One key benefit of this approach is that the behavior of a system under faults does not have to be pre-defined as it is normally done. Instead, a system can be simulated in detail and injected with faults to determine its failure modes. The thesis describes how object-oriented design is used to incorporate this methodology into a general purpose design and fault injection package called DEPEND. A software model is presented that uses abstractions of application programs to study the behavior and effect of software on hardware faults in the early design stage when actual code is not available. Finally, an acceleration technique that combines hierarchical simulation, time acceleration algorithms and hybrid simulation to reduce simulation time is introduced.

  8. Net effect of many gravitational fields on the intensity of celestial light sources. Master's thesis

    SciTech Connect

    Cipperly, G.E.

    1982-12-01

    This thesis investigates the lens-like action of the gravitational fields of celestial bodies, which can alter the apparent intensity of more distant sources. Previous work in this area has shown that the chance of an individual body being sufficiently well aligned with a source to cause a very large gravitational intensity change is small. The issue addressed in this study is the possibility of there being a significant total change in the intensity of a source due to the combined effects of the gravitational fields of all celestial bodies, and in particular, the potential impact on intensity distance measurements, that is, determination of the distances of celestial light sources by means of intensity comparisons. It is first shown that the problem can be treated in flat space by associating an appropriate index of refraction with gravitational fields. A wave approach is taken in deriving the total deflection of a ray by the field of a single point mass. A statistical analysis is then performed to determine the expression for the mean total change in the intensity of celestial light sources due to the combined fields of all intervening bodies.

  9. The Radical Plasticity Thesis: How the Brain Learns to be Conscious.

    PubMed

    Cleeremans, Axel

    2011-01-01

    In this paper, I explore the idea that consciousness is something that the brain learns to do rather than an intrinsic property of certain neural states and not others. Starting from the idea that neural activity is inherently unconscious, the question thus becomes: How does the brain learn to be conscious? I suggest that consciousness arises as a result of the brain's continuous attempts at predicting not only the consequences of its actions on the world and on other agents, but also the consequences of activity in one cerebral region on activity in other regions. By this account, the brain continuously and unconsciously learns to redescribe its own activity to itself, so developing systems of meta-representations that characterize and qualify the target first-order representations. Such learned redescriptions, enriched by the emotional value associated with them, form the basis of conscious experience. Learning and plasticity are thus central to consciousness, to the extent that experiences only occur in experiencers that have learned to know they possess certain first-order states and that have learned to care more about certain states than about others. This is what I call the "Radical Plasticity Thesis." In a sense thus, this is the enactive perspective, but turned both inwards and (further) outwards. Consciousness involves "signal detection on the mind"; the conscious mind is the brain's (non-conceptual, implicit) theory about itself. I illustrate these ideas through neural network models that simulate the relationships between performance and awareness in different tasks.

  10. Random vibration analysis of the Topaz-II nuclear reactor power system. Master`s thesis

    SciTech Connect

    Campbell, S.E.

    1995-06-01

    The TOPAZ-II Ya-21U is one of six Russian made space nuclear power systems which is based on theomionic power conversion. The U.S. is presently analyzing TOPAZ-II to determine the reliability and feasibility of using this system. A structural analysis test was conducted on the TOPAZ unit in May 1993 to provide data from which modal parameters could be identified. This test showed the fundamental frequency to be 10.5 Hz, yet the test results that the Russians conducted identified a fundamental frequency of 5 Hz. Another finite element model was created incorporating new developments in TOPAZ-II and modifications to the finite element model to better simulate the mass properties of the TOPAZ-II2. A second structural analysis test was conducted on the TOPAZ unit 06-09 September 1994. This thesis focuses on the random vibration analysis of the TOPAZ-II Ya-2lU utilizing the most recent test results and the Master Series (updated version) I-DEAS software. The modal respose of the model and simulated random vibration tests were within 8.33%. This model is a feasible tool which can be used to analyze the TOPAZ unit without testing the unit to fatigue.

  11. Hydrodynamics and morphodynamics of shallow tidal channels and intertidal flats. Doctoral thesis

    SciTech Connect

    Friedrichs, C.T.

    1993-02-01

    In this thesis, mechanisms which control morphodynamics of shallow tidal embayments are investigated analytically. In the process of exploring these mechanisms (specifically asymmetries in bottom stress), Tau, basis momentum and mass balances which govern flow in these systems are clarified. Temporal asymmetries in Tau are investigated via a new perturbation scheme which quantifies nonlinear processes and combines geometric controls on asymmetry into a single non-dimensional parameter. Implications of spatial asymmetries in Tau are investigated through stability criteria based on a uniform distribution of Tau. Morphologic observations of both tidal channels and intertidal flats are consistent with a uniform distribution of Tau at equilibrium. Investigation of morphodynamic mechanisms leads to scalings of momentum and continuity which diverge from classical models. Scalings for prismatic channels with strong tidal asymmetries indicate friction often dominates acceleration in the momentum equation. The resulting zero-inertia balance gives a time-varying diffusion equation which requires along-channel amplitude to decay. Uniform Tau justifies a new scaling of continuity for exponentially-shaped channels. In such channels, along-channel gradients in tidal velocity are small and are often dominated by gradients in cross-sectional area. The resulting first-order wave equation allows only amplitude, forward propagating waveforms which are independent of channel length. Tidal channels Hydrodynamics, Tidal flats.

  12. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    PubMed

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study.

  13. [The human in the art: Henrik Have's painting for a medical thesis].

    PubMed

    Kristiansen, Jette E; Permin, Henrik

    2002-01-01

    A painting made by the Danish painter and author Henrik Have (born 1946) illustrates the front page of Jette E. Kristiansen's medical thesis The Antimicrobial Activity of Psychotherapeutic Drugs and Stereo-isomeric Analogues (1990). The painting illustrates beautifully that art and science can go hand in hand. Even very complicated chemical, pharmacological and microbiological questions can be expressed by means of colours and by means of symbols used in everyday life, such as a spiral (DNA), or a pair of hands expressing working together. Prayers, wishes and the most difficult questions in receptor stereo-chemistry in eucaryotic and procaryotic cell-systems are illustrated in this painting. Synthetic chemistry and pharmacology are linked in the development of the synthetic dyes. The chemical colours are often the same in dyes and drugs. The red colour in the pharmacology is associated with the antibiotic drugs as sulfonamides as well as with the staining of Gram-negative bacteria. The yellow colour is associated with the antibiotic drugs, quinolones and the Ziehl-Neelsen staining for tubercle bacillii. The blue colour is associated with the psychoactive drugs, phenotiazines, as well as with methylenblue staining and the staining of Gram-positive bacteria. These association and symbols have been used in this painting.

  14. Soviet Nordic nuclear-weapon free-zone proposal. Master's thesis

    SciTech Connect

    Lumsden, C.A.

    1990-06-01

    This thesis examines the Soviet proposal and its ramifications for the United States and the West. The central theme running through each Soviet proposal has been removal of American nuclear guarantees. Preservation of US national security interests and hence US ability to extend its forward defense would be gravely threatened by such a NWFZ. However, unilateral agreement on a NWFZ is unlikely by the anticipated members of the Nordic NWFZ the US, USSR, Denmark, Norway, Finland, Iceland, Greenland, and Sweden. The US has military installations in Iceland and Greenland and banning of nuclear weapons during wartime is inconceivable. The question then arises as to which nation or groups of nations will dominate and which will acquiesce. Inevitably the debate breaks down to a tug of war between the two superpowers. It is really the politics surrounding the nuclear weapons that is the heart of the nuclear-free-zone debate. Changing world politics demand that the West develop a unified strategy toward the USSR. Through NATO it must preserve its vital economic political and military objectives in the Northern Flank. Flexible naval forces and strong political and economic ties to the governments of the nations bordering the Baltic are essential. Strong NATO naval forces operating in the Baltic Sea must be seen as guarantors of the West's strategic aims and interests. A Nordic NWFZ would prevent this.

  15. The Heritage of Herding and Southern Homicide: Examining the Ecological Foundations of the Code of Honor Thesis

    ERIC Educational Resources Information Center

    Baller, Robert D.; Zevenbergen, Matthew P.; Messner, Steven F.

    2009-01-01

    The authors examine the ecological foundations of the thesis of a "code of honor" as an explanation for southern homicide. Specifically, they consider the effects of indicators of ethnic groups that migrated from herding economies (the Scotch-Irish), cattle and pig herding, and the relative importance of agricultural production across…

  16. Peer Portal: Quality Enhancement in Thesis Writing Using Self-Managed Peer Review on a Mass Scale

    ERIC Educational Resources Information Center

    Aghaee, Naghmeh; Hansson, Henrik

    2013-01-01

    This paper describes a specially developed online peer-review system, the Peer Portal, and the first results of its use for quality enhancement of bachelor's and master's thesis manuscripts. The peer-review system is completely student driven and therefore saves time for supervisors and creates a direct interaction between students without…

  17. 7 CFR 3402.6 - Overview of the special international study and/or thesis/dissertation research travel allowance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Overview of the special international study and/or thesis/dissertation research travel allowance. 3402.6 Section 3402.6 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND...

  18. How Doctoral Students and Graduates Describe Facilitating Experiences and Strategies for Their Thesis Writing Learning Process: A Qualitative Approach

    ERIC Educational Resources Information Center

    Odena, Oscar; Burgess, Hilary

    2017-01-01

    This study considered the sources of facilitating experiences and strategies for thesis writing from doctoral students and graduates (N = 30). The sample was balanced between science and social science knowledge areas, with equal numbers of English as Second Language (ESL) participants in both groups. Semi-structured in-depth interviews were used…

  19. Getting used to academic public speaking: global self-esteem predicts habituation in blood pressure response to repeated thesis presentations.

    PubMed

    Elfering, Achim; Grebner, Simone

    2012-06-01

    Global self-esteem was tested to predict quicker cardiovascular adaptation during stressful oral thesis presentation and faster habituation from the first to the second and third thesis presentations. Nineteen graduate students initially rated their global self-esteem and afterwards orally presented their theses proposals in 20-min presentations to their thesis supervisor and peers. A second and third presentation of the revised thesis concepts took place at 4-weeks intervals. Ambulatory blood pressure and heart rate were assessed repeatedly during the presentations. Post-talk self ratings of stressfulness indicated presentations to be a strong public speaking stressor. One hundred and thirty-eight measurements of systolic (SBP), diastolic blood pressure (DBP), and heart rate (HR) showed a significant adaptation (decrease) during presentations. There was an overall mean level decrease from the first to the second, and the second to the third presentations in HR, but not in SBP and DBP. However, habituation in SBP and DBP across three presentations was significantly faster (p < .05) in those participants who initially reported higher levels of global self-esteem. Higher global self-esteem did not foster adaptation within the presentations. Self-esteem is discussed as an important individual resource that allows successful coping with recurring evaluative threats.

  20. The Advanced Interdisciplinary Research Laboratory: A Student Team Approach to the Fourth-Year Research Thesis Project Experience

    ERIC Educational Resources Information Center

    Piunno, Paul A. E.; Boyd, Cleo; Barzda, Virginijus; Gradinaru, Claudiu C.; Krull, Ulrich J.; Stefanovic, Sasa; Stewart, Bryan

    2014-01-01

    The advanced interdisciplinary research laboratory (AIRLab) represents a novel, effective, and motivational course designed from the interdisciplinary research interests of chemistry, physics, biology, and education development faculty members as an alternative to the independent thesis project experience. Student teams are assembled to work…

  1. Getting Personal--What Does It Mean? A Critical Discussion of the Personal Dimension of Thesis Supervision in Higher Education

    ERIC Educational Resources Information Center

    Bengtsen, Soren S. E.

    2011-01-01

    The argument of the article is that contemporary research into thesis supervision overlooks important didactical features of the supervisory dialogue because of its focus on general pedagogical categories. Entailing this argument I suggest that the personal dimension should be seen not only as a means to enhanced communication between supervisor…

  2. Bernstein and the Explanation of Social Disparities in Education: A Realist Critique of the Socio-Linguistic Thesis

    ERIC Educational Resources Information Center

    Nash, Roy

    2006-01-01

    Can an explanation of the origins of social disparities in educational achievement be assisted by a critical examination of Bernstein's sociology? This central question is approached by a consideration of the status of Bernstein's socio-linguistic thesis. The focus is on the nature of the explanations provided. The paper asks: What is the…

  3. Brotherhood or Brothers in the "Hood"? Debunking the "Educated Gang" Thesis as Black Fraternity and Sorority Slander

    ERIC Educational Resources Information Center

    Hughey, Matthew W.

    2008-01-01

    In this article the author explores the controversial thesis that African American Collegiate Fraternities and Sororities, also known as Black Greek Letter Organizations (BGLOs), are "educated gangs". First, the author examines this polemic as a "truth claim" and compares BGLOs and gangs through: (1) hazing; (2) rape and substance abuse; (3)…

  4. ERBE S10 WFOV SF NAT

    Atmospheric Science Data Center

    2016-06-13

    ... Absorption of Solar Radiation by Clouds The results of the study demonstrate the present shortcoming in the current knowledge of cloud ... continuously view the earth disc (plus a small ring of space). The measurements are continuous over the entire globe for NOAA-9 and ...

  5. ERBE S10 WFOV NF NAT

    Atmospheric Science Data Center

    2016-06-09

    ... atmospheric aerosols from biomass burning may offset global warming caused by greenhouse gases. Absorption of Solar Radiation by ... Instruments: these two fixed detectors continuously view the earth disc (plus a small ring of space). The measurements are continuous over ...

  6. ERBE S10 MFOV NF NAT

    Atmospheric Science Data Center

    2016-06-09

    ... atmospheric aerosols from biomass burning may offset global warming caused by greenhouse gases. Absorption of Solar Radiation by ... Instruments: these two fixed detectors continuously view the earth disc (plus a small ring of space). The measurements are continuous over ...

  7. ERBE S10 MFOV SF NAT

    Atmospheric Science Data Center

    2016-06-09

    ... atmospheric aerosols from biomass burning may offset global warming caused by greenhouse gases. Absorption of Solar Radiation by ... Instruments: these two fixed detectors continuously view the earth disc (plus a small ring of space). The measurements are continuous over ...

  8. ERBE S10N WFV NF NAT

    Atmospheric Science Data Center

    2016-06-13

    ... continuously view the earth disc (plus a small ring of space). The measurements are continuous over the entire globe for NOAA-9 and ... scanner instruments on board the NOAA-9 and NOAA-10 satellites provide global coverage, while the ERBE scanner instrument onboard ...

  9. ERBE S10N WFV SF NAT

    Atmospheric Science Data Center

    2016-06-14

    ... Level:  L3 Platform:  ERBS, NOAA-9 and -10 Instrument:  NonScanner Spatial ... The measurements are continuous over the entire globe for NOAA-9 and NOAA-10, and between 57 degrees north and south latitudes for ERBS ...

  10. Reminiscing about thesis work with E T Jaynes at Stanford in the 1950s

    NASA Astrophysics Data System (ADS)

    Cummings, Frederick W.

    2013-11-01

    Abstract A short personal and historical account of the field of radiation interacting with (two-level) atoms is given. Subsequent to 1963, developments and extensions have been extensive and fruitful. One of the most fortunate changes in my life came in late 1957. I was looking for a thesis advisor, after two years of graduate course-work at Stanford. I chanced to see a notice of an upcoming lecture by a professor named Edwin T Jaynes. I could not understand from the announcement what he intended to talk about, but I was searching; I went to find out. That decision was a very lucky one. Ed was talking about a subject that inspired him then, and had been for many years, namely his concept of 'Max-Ent'. 'Maximum-Entropy' is a subject now close to my heart also. Ed's very-clear, well-thought-out papers, spread over many subsequent years, are transforming the field of probability (albeit too gradually) to the 'subjective' outlook of Bayes. (A recent book 'Maximum Entropy and Ecology' [1] will probably convert many nay-sayers to 'Max-Ent'.) I went into Ed's office (late 1957) and asked if I could work with him on a thesis. Did he have a problem for me? Yes, he did. Somewhat to my surprise, he asked me to look into the 'maser problem', involving a comparison of the semi-classical theory of radiation to a proper quantum treatment. To make a two-year story short, Ed's guidance was expert. (I imagine that if another of Ed's students (e.g. Joe Eberly) had come into his office fifteen minutes before me, the 'Jaynes-Cummings' (J-C) model would now perhaps be called otherwise, e.g., the 'J-E' model). In the two-year time frame (~1958-60), Ed had a number of other PhD dissertation students whom I knew; these included Joe Eberly, Doug Scalapino, Baldwin Robertson, Larry Davis and Mike Duggan. My thesis work under Ed reminds me of a story about Michelangelo and his famous 'Pieta'. Michelangelo was an old man about then, so he hired a young craftsman to do much of the physical

  11. Efficient modeling of interconnects and capacitive discontinuities in high-speed digital circuits. Thesis

    NASA Technical Reports Server (NTRS)

    Oh, K. S.; Schutt-Aine, J.

    1995-01-01

    Modeling of interconnects and associated discontinuities with the recent advances high-speed digital circuits has gained a considerable interest over the last decade although the theoretical bases for analyzing these structures were well-established as early as the 1960s. Ongoing research at the present time is focused on devising methods which can be applied to more general geometries than the ones considered in earlier days and, at the same time, improving the computational efficiency and accuracy of these methods. In this thesis, numerically efficient methods to compute the transmission line parameters of a multiconductor system and the equivalent capacitances of various strip discontinuities are presented based on the quasi-static approximation. The presented techniques are applicable to conductors embedded in an arbitrary number of dielectric layers with two possible locations of ground planes at the top and bottom of the dielectric layers. The cross-sections of conductors can be arbitrary as long as they can be described with polygons. An integral equation approach in conjunction with the collocation method is used in the presented methods. A closed-form Green's function is derived based on weighted real images thus avoiding nested infinite summations in the exact Green's function; therefore, this closed-form Green's function is numerically more efficient than the exact Green's function. All elements associated with the moment matrix are computed using the closed-form formulas. Various numerical examples are considered to verify the presented methods, and a comparison of the computed results with other published results showed good agreement.

  12. On recursive least-squares filtering algorithms and implementations. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Hsieh, Shih-Fu

    1990-01-01

    In many real-time signal processing applications, fast and numerically stable algorithms for solving least-squares problems are necessary and important. In particular, under non-stationary conditions, these algorithms must be able to adapt themselves to reflect the changes in the system and take appropriate adjustments to achieve optimum performances. Among existing algorithms, the QR-decomposition (QRD)-based recursive least-squares (RLS) methods have been shown to be useful and effective for adaptive signal processing. In order to increase the speed of processing and achieve high throughput rate, many algorithms are being vectorized and/or pipelined to facilitate high degrees of parallelism. A time-recursive formulation of RLS filtering employing block QRD will be considered first. Several methods, including a new non-continuous windowing scheme based on selectively rejecting contaminated data, were investigated for adaptive processing. Based on systolic triarrays, many other forms of systolic arrays are shown to be capable of implementing different algorithms. Various updating and downdating systolic algorithms and architectures for RLS filtering are examined and compared in details, which include Householder reflector, Gram-Schmidt procedure, and Givens rotation. A unified approach encompassing existing square-root-free algorithms is also proposed. For the sinusoidal spectrum estimation problem, a judicious method of separating the noise from the signal is of great interest. Various truncated QR methods are proposed for this purpose and compared to the truncated SVD method. Computer simulations provided for detailed comparisons show the effectiveness of these methods. This thesis deals with fundamental issues of numerical stability, computational efficiency, adaptivity, and VLSI implementation for the RLS filtering problems. In all, various new and modified algorithms and architectures are proposed and analyzed; the significance of any of the new method depends

  13. Marine microbial production of dimethylsulfide from dissolved dimethylsulfoniopropionate. Ph. D. Thesis

    SciTech Connect

    Ledyard, K.M.

    1993-02-01

    Dimethylsulfide (DMS) plays a central role in the transfer of sulfur from the ocean to the atmosphere and ultimately to land. The most abundant volatile organosulfur compound in seawater, DMS is believed to account for the bulk of the sea-to-air biogenic sulfur flux. DMS has also been implicated as the major precursor of submicron-sized sulfate aerosol over the ocean. This aerosol acts as an effective site for cloud droplet condensation suggesting a possibly important role for DMS in marine cloud formation. In the ocean, the precursor of DMS is presumed to be the zwitterionic sulfonium compound dimethylsulfoniopropionate (DMSP), a common osmoticum in certain classes of marine algae. While some algae can cleave DMSP intracellularly to form DMS, correlation of DMS concentrations with indicators of algal productivity on a local scale is poor. This thesis focuses on an alternative pathway of DMS formation: microbial cleavage of dissolved (extracellular) DMSP. In laboratory studies, bacteria able to cleave DMSP to form DMS were isolated from seawater by a DMSP enrichment technique, and the kinetics of DMSP uptake and DMS production were examined closely in pure cultures of a bacterial isolate from the Sargasso Sea. The isolate could grow with both DMSP and acrylic acid, one of the products of DMSP cleavage, as the sole source of carbon and energy, and the enzyme catalyzing DMSP cleavage appeared to be induced by both of these compounds. Kinetic parameters were estimated for DMSP uptake and cleavage by whole cells. Comparison of the 16S rRNA sequence of this isolate with that of known eubacteria showed that it was most closely related to Erythrobacter longus, an aerobic, bacteriochlorophyll-containing member of the alpha proteobacteria.

  14. Magnetic levitation and confinement of molten metals. Ph.D Thesis

    SciTech Connect

    Roy, S.S.

    1993-12-31

    Electromagnetic forces generated within the bulk of a liquid metal, due to imposed alternating magnetic field, can alter the shape of the free surface of the liquid metal. Most of the research in this area has been focused on theoretical development of electromagnetic processes and there is a lack of well defined experimental results with which to verify the theoretical models. In this thesis, the interaction of electromagnetic field structure with liquid metals was studies both from theoretical and experimental viewpoints. Levitation and shaping experiments were successfully carried out with liquid sodium in mineral oil in a cone-shaped coil. Small droplets ranging from 1.2 to 2.1 gm of liquid sodium were levitated. The modeling of a levitated droplet in an electromagnetic field was carried out using the Free Movement method. This is a surface coupled model where the skin depth is assumed to be zero. There was a good match between the experimental and predicted results. The shaping experiments were also carried out using liquid sodium in a cylindrical coil. Liquid sodium was repelled from the wall of the container and the meniscus profile was measured. The experimental results were compared with the results predicted by the mathematical model. The comparison was good away from the inductor but the model did not predict the shape near the inductor due to fluid flow during shaping. The mathematical model is used to predict the meniscus shapes of liquid steel under an imposed electromagnetic field. This technique is used to investigate the effect of applied magnetic fields on the static meniscus shapes of a liquid steel column and on the equilibrium meniscus shape of liquid steel in the mold of a continuous caster when there is not relative movement between the model and the strand. The heating rate of liquid steel due to induced eddy currents within the bulk of the metal is also studied.

  15. Finding the right doctoral thesis – an innovative research fair for medical students

    PubMed Central

    Steffen, Julius; Grabbert, Markus; Pander, Tanja; Gradel, Maximilian; Köhler, Lisa-Maria; Fischer, Martin R.; von der Borch, Philip; Dimitriadis, Konstantinos

    2015-01-01

    Introduction: The importance of research, as promoted by the CanMEDS framework, is widely acknowledged. Many medical students in Germany work on a research project as part of their doctoral thesis whilst still going to medical school. However, a significant amount of projects are abandoned unfinished, which leads to substantial wastage of resources. One reason for this is an information deficit concerning undergraduate research projects. Project description: To counteract this, we introduced an annual event at LMU Munich called DoktaMed with more than 600 visitors each year. It combines medical convention and research fair including keynote lectures, workshops and poster sessions as well as an exhibition of research groups and institutes. DoktaMed is a peer-to-peer event organized by a team of 40 students. Results: A needs analysis before its implementation underlined the information deficit as a possible cause for the high rate of abandoned projects. In the annual evaluation, visitors of DoktaMed rate the event with an average grade of 2.1 on a six-level Likert scale (n=558, SD=1.06, with "1=very good", "6=poor"). They stated to now feel better informed about the topic and regarded visiting DoktaMed as a worthwhile investment of time. Discussion: Students are generally satisfied with the event and feel better informed after visiting DoktaMed. However, many students never visit DoktaMed for various reasons. A possible improvement would be to present a greater number of clinical studies in addition to the laboratory work that DoktaMed focuses on now. Conclusion: Evaluation after six years of DoktaMed is very promising. Visitors seem to be better informed. Nevertheless there is space for improvement in order to get more students and more faculty members involved. More studies are needed to assess long-term effects. PMID:26413167

  16. The Radical Plasticity Thesis: How the Brain Learns to be Conscious

    PubMed Central

    Cleeremans, Axel

    2011-01-01

    In this paper, I explore the idea that consciousness is something that the brain learns to do rather than an intrinsic property of certain neural states and not others. Starting from the idea that neural activity is inherently unconscious, the question thus becomes: How does the brain learn to be conscious? I suggest that consciousness arises as a result of the brain's continuous attempts at predicting not only the consequences of its actions on the world and on other agents, but also the consequences of activity in one cerebral region on activity in other regions. By this account, the brain continuously and unconsciously learns to redescribe its own activity to itself, so developing systems of meta-representations that characterize and qualify the target first-order representations. Such learned redescriptions, enriched by the emotional value associated with them, form the basis of conscious experience. Learning and plasticity are thus central to consciousness, to the extent that experiences only occur in experiencers that have learned to know they possess certain first-order states and that have learned to care more about certain states than about others. This is what I call the “Radical Plasticity Thesis.” In a sense thus, this is the enactive perspective, but turned both inwards and (further) outwards. Consciousness involves “signal detection on the mind”; the conscious mind is the brain's (non-conceptual, implicit) theory about itself. I illustrate these ideas through neural network models that simulate the relationships between performance and awareness in different tasks. PMID:21687455

  17. An Investigation of Non-Thesis Master's Program Geography Teacher Candidates' Attitudes towards Teaching Profession regarding Several Socio-Cultural Features

    ERIC Educational Resources Information Center

    Sezer, Adem; Kara, Hasan; Pinar, Adnan

    2011-01-01

    The purpose of this study is to examine the attitudes of non-thesis master's degree program: geography teacher candidates towards teaching profession regarding several socio-cultural features. The study was conducted in different universities with 218 geography teacher candidates enrolled in the geography education non-thesis master's degree…

  18. Method for optimizing resource allocation in a government organization. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Afarin, James

    1994-01-01

    The managers in Federal agencies are challenged to control the extensive activities in government and still provide high-quality products and services to the American taxpayers. Considering today's complex social and economic environment and the $3.8 billion daily cost of operating the Federal Government, it is evident that there is a need to develop decision-making tools for accurate resource allocation and total quality management. The goal of this thesis is to provide a methodical process that will aid managers in Federal Government to make budgetary decisions based on the cost of services, the agency's objectives, and the customers' perception of the agency's product. A general resource allocation procedure was developed in this study that can be applied to any government organization. A government organization, hereafter the 'organization,' is assumed to be a multidivision enterprise. This procedure was applied to a small organization for the proof of the concept. This organization is the Technical Services Directorate (TSD) at the NASA Lewis Research Center in Cleveland, Ohio. As part of the procedure, a nonlinear programming model was developed to account for the resources of the organization, the outputs produced by the organization, the decision-maker's views, and the customers' satisfaction with the organization. The information on the resources of the organization was acquired from current budget levels of the organization and the human resources assigned to the divisions. The outputs of the organization were defined and measured by identifying metrics that assess the outputs, the most challenging task in this study. The decision-maker's views are represented in the model as weights assigned to the various outputs and were quantified by using the analytic hierarchy process. The customer's opinions regarding the outputs of the organization were collected through questionnaires that were designed for each division individually. Following the philosophy of

  19. Structure-activity predictions of properties of organophosphorus pesticides and chemical agents important for optical detection. Master`s thesis

    SciTech Connect

    Porte, R.E.

    1995-12-01

    This thesis presents the results of an investigation for estimating various physicochemical properties of chemical warfare agents and organophosphorus pesticides. The determination of aqueous solubility, - octanol/water partition coefficients, and alkaline hydrolysis rate constants will be used in the development of a chemical sensor using fiber optic spectroscopy. These three parameters will effect the limit of detection for each compound by limiting the concentration in the detector. The parameters were estimated by linear free energy relationships and quantitative structure activity relationships using experimental data for compounds of similar chemical structure. The results of this thesis showed that the hydrophobic medium represented by 1-octanol did concentrate the OP pesticides but did not significantly concentrate CWA, CWA simulants, or CWA hydrolysis products. Correlations were evaluated for six classes of organophosphorus compounds. The limitation of this approach to predicting physicochemical parameters is not in the molecular descriptors used in the regression equations but in the availability of existing experimental data.

  20. Development of ground support equipment for the NPS ionospheric spectroscopy and atmospheric chemistry (ISAAC) ultraviolet spectrograph. Master`s thesis

    SciTech Connect

    Fragiskos, L.

    1995-06-01

    This thesis details the design of Ground Support Equipment (GSE) for the Naval Postgraduate School`s Ionospheric Spectroscopy and Atmospheric Chemistry (ISAAC) Ultraviolet Spectrograph. ISAAC is one of the several experiments to be flown on the Advanced Research and Global Observation Satellite (ARGOS) in 1996. The GSE consists of several software programs written in LabVIEW. These programs simulate the timing signals that ISAAC will receive from the satellite bus. In addition, the programs acquire serial data from ISAAC, perform a serial to parallel conversion and display the resulting spectra. The GSE will allow testing of the spectrograph prior to the interface with the satellite bus. Although the complete flight instrument is not yet available for testing, this thesis describes how the GSE-to-ISAAC interface will be made and how it should be operated. Finally, some hardware/software incompatibilities are identified.

  1. [The effect of public defense of a doctoral thesis on the heart rate of the doctoral candidate].

    PubMed

    Kiljander, Toni; Toikka, Jyri; Koskenvuo, Juha; Jaakkola, Ilkka

    2011-01-01

    The effect of public defense of a doctoral thesis on the heart rate of the doctoral candidate Most doctoral candidates find the public defense of a doctoral thesis an exciting and stressful experience. In this study, Holter recording during the defense was made for four doctoral candidates of the Faculty of Medicine. Maximum heart rate among the subjects was on the average 172 beats/min with a median heart rate of 116 beats/min. Sympathicotonia and release of stress hormones associated with the defense raise the heart rate to levels that may be very high for several hours. This is a risk factor for a coronary event and should be considered, if the doctoral candidate has coronary heart disease, carries risk factors for coronary heart disease, or is an elderly person.

  2. Managing risk and marginalizing identities: on the society-of-captives thesis and the harm of social dis-ease.

    PubMed

    Arrigo, Bruce A

    2013-06-01

    This article develops the constitutive features of the society-of-captives thesis as suggested by Arrigo and Milovanovic, and Arrigo, Bersot, and Sellers. The relevance of this thesis is briefly explored in relation to the institutional and community-based treatment philosophies that currently inform the mental health and criminal justice systems. This exploration specifies how risk (being human and doing humanness differently) is managed symbolically, linguistically, materially, and culturally. The management of this risk extends to the kept as well as to their keepers, regulators, and watchers (i.e., the society of captives). This article calls for a new clinical praxis (being/doing a critical mindfulness) designed to overcome the totalizing madness (the harm of social dis-ease) that follows from managing risk fearfully and marginalizing identities desperately as reified recursively through society's captivity. The ethical underpinnings of this clinical praxis represent an emergent direction for undertaking correctional policy reform.

  3. Nursing the future: a re-examination of the professionalization thesis in the light of some recent developments.

    PubMed

    Parkin, P A

    1995-03-01

    It is now 6 years since Salvage's (1988) analysis of the position of nursing within the professionalization process; this was written in the light of the aspirations of Project 2000. Recently there have been several significant policy statements from the United Kingdom Central Council which appear to be pursuing professional status despite Salvage's contention that nursing's leaders know 'that full professional status for nursing cannot be achieved'. Elements of these statements are discussed in relation to the professionalization thesis. Using the examples of nurse prescribing and managerialism, it is argued that the deprofessionalization thesis is more appropriate to nursing since the ideals of autonomy, authority and status are being eroded in the new managerialist post-Griffiths National Health Service culture. A positive deprofessionalization notion is put forward which highlights and re-emphasizes the caring role through the new occupational strategy of Assessment of Prior Experiential Learning (APEL).

  4. [Medecine and chemistry in the context of the Enlightenment: the thesis of the Lausanne physician Marc-Louis Vullyamoz].

    PubMed

    Terrier, Georges

    2003-01-01

    The chemico-medical essay "De sale lactis essentiali" is a thesis presented in Leyden in 1756 by a physician from Lausanne, M.-L. Vullyamoz, to obtain the medical degree. It shows that chemistry has become a university science connected with medicine and that combustion was explained at that time by G. E. Stahl's theory of the phlogiston. It reminds us that the hypotheses of this German physician, which were part of the animistic doctrine, were widely adopted in Europe. In chemistry they began to fade in 1789 after the publication of Lavoisier's work on oxydation. Nevertheless, they have contributed to establish a modern science. In medicine Stahl's animism evolved towards vitalism, which survived in several forms. Vullyamoz's thesis, which presents chemical experiences intended to analyse and promote a popular medicine, is a testimony of the spirit of Enlightenment, which rejects dogmatism and tries to understand facts through observation and the use of reason.

  5. Supporting Education PhD and DEd Students to Become Confident Academic Writers: An Evaluation of Thesis Writers' Circles

    ERIC Educational Resources Information Center

    Larcombe, Wendy; McCosker, Anthony; O'Loughlin, Kieran

    2007-01-01

    This paper critically evaluates the pilot of a Thesis Writers' Circles program offered to Education PhD and DEd students at the University of Melbourne in semester 2, 2005. The analysis focuses on the needs of those students that were felt to be well-met by this model of support. Broadly, the paper identifies two distinct but inter-related themes:…

  6. Application of the Modular Command and Control Evaluation Structure to a Strategic Defense Initiative command and control system. Master's thesis

    SciTech Connect

    Kramer, G.K.

    1987-03-01

    This thesis focuses on relating a generic evaluation structure, the Modular Command and Control Evaluation Structure (MCES), to the battle management (BM) and command, control and communication (C3) issues of the Strategic Defense Initiative (SDI). To do this, the area of SDI battle management, command and control (C2), and communications are reviewed and explained as well as the MCES. This provides useful descriptive analysis required for identifying and measuring proposed BM/C3 architectures.

  7. [Beyond Weimar Culture--the significance of the Forman thesis for a cultural approach to the history of science].

    PubMed

    Trischler, Helmuth; Carson, Cathryn; Kojevnikov, Alexei

    2008-12-01

    '"Forman thesis', published in 1971, argued for a historical linkage among the intellectual atmosphere of Weimar Germany, popular revolts against determinism and materialism, and the creation of the revolutionary new theory of quantum mechanics. Paul Forman's long essay on "Weimar Culture" has shaped research agendas in numerous fields, from the history and philosophy of physics to German history to the sociology of scientific knowledge. Despite its status as a classic and its transformative effect, Weimar Culture has always inspired as much critique as assent. In particular in the history of science, cohorts of students and two generations of scholars have debated the Forman thesis as a conceptual tool for linking scientific change with cultural processes. The Forman thesis raises critical questions for both the ongoing debates over cultural approaches to the history of science and the burgeoning newer scholarship on physics in and beyond Weimar Germany. Exploring these implications has been the aim of a transnational project of the three authors of this article which sheds some light on these debates and briefly introduces the following papers of this special issue devoted to Paul Forman and his seminal works in the history of science.

  8. Evolution and Development of Dual Ingestion Systems in Mammals: Notes on a New Thesis and Its Clinical Implications

    PubMed Central

    Alberts, Jeffrey R.; Pickler, Rita H.

    2012-01-01

    Traditionally, the development of oral feeding is viewed as a continuous, unitary process in which reflex-dominated sucking behavior gives rise to a more varied and volitional feeding behavior. In contrast, we consider the thesis that the infant develops two separable ingestive systems, one for suckling and one for feeding. First, we apply an evolutionary perspective, recognizing that suckling-feeding is a universal, mammalian developmental sequence. We find that in mammalian evolution, feeding systems in offspring were established prior to the evolution of lactation, and therefore suckling is a separable feature that was added to feeding. We next review an experimental literature that characterizes suckling and feeding as separable in terms of their topography, sensory controls, physiological controls, neural substrates, and experience-based development. Together, these considerations constitute a view of “dual ingestive systems.” The thesis, then, is that suckling is not a simple precursor of feeding but is a complete behavior that emerges, forms, and then undergoes a dissolution that overlaps with the emergence of independent feeding. This thesis guides us to focus differently on the challenges of properly managing and facilitating oral ingestion in infants, especially those born preterm, prior to the developmental onset of suckling. PMID:23028391

  9. A survey of doctorates by thesis among general practitioners in the British Isles from 1973 to 1988.

    PubMed

    Williams, W O

    1990-12-01

    Doctors who were general practitioners in the period 1973-88 and had written a successful MD or PhD thesis were identified. Of 96 doctorates, 64 were MDs and 32 PhDs. Fourteen doctors had obtained their MD before becoming general practitioners and the remaining 50 after becoming general practitioners. Twenty of the 64 doctors were full time or part time members of a university department of general practice; six of these were professors. In this 16 year study the mean annual number of MDs written by doctors while in general practice was three, compared with five in the previous 15 years. Of the PhDs, 11 were obtained before starting a medical course, six during the pre-clinical period, three after qualifying but before entry into general practice and 12 after entry into general practice. Ninety two per cent of the 50 doctors who obtained their MDs while in general practice and 84% of all the doctors with MDs continued to do research afterwards. Further research was carried out by 81% of doctors with a PhD. The best way of producing good researchers in general practice is to encourage doctors to accept the challenge of writing a PhD or an MD thesis. This study has shown that writing such a thesis encourages rather than discourages a doctor to undertake further research.

  10. Evolution and development of dual ingestion systems in mammals: notes on a new thesis and its clinical implications.

    PubMed

    Alberts, Jeffrey R; Pickler, Rita H

    2012-01-01

    Traditionally, the development of oral feeding is viewed as a continuous, unitary process in which reflex-dominated sucking behavior gives rise to a more varied and volitional feeding behavior. In contrast, we consider the thesis that the infant develops two separable ingestive systems, one for suckling and one for feeding. First, we apply an evolutionary perspective, recognizing that suckling-feeding is a universal, mammalian developmental sequence. We find that in mammalian evolution, feeding systems in offspring were established prior to the evolution of lactation, and therefore suckling is a separable feature that was added to feeding. We next review an experimental literature that characterizes suckling and feeding as separable in terms of their topography, sensory controls, physiological controls, neural substrates, and experience-based development. Together, these considerations constitute a view of "dual ingestive systems." The thesis, then, is that suckling is not a simple precursor of feeding but is a complete behavior that emerges, forms, and then undergoes a dissolution that overlaps with the emergence of independent feeding. This thesis guides us to focus differently on the challenges of properly managing and facilitating oral ingestion in infants, especially those born preterm, prior to the developmental onset of suckling.

  11. KARL: A Knowledge-Assisted Retrieval Language. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Triantafyllopoulos, Spiros

    1985-01-01

    Data classification and storage are tasks typically performed by application specialists. In contrast, information users are primarily non-computer specialists who use information in their decision-making and other activities. Interaction efficiency between such users and the computer is often reduced by machine requirements and resulting user reluctance to use the system. This thesis examines the problems associated with information retrieval for non-computer specialist users, and proposes a method for communicating in restricted English that uses knowledge of the entities involved, relationships between entities, and basic English language syntax and semantics to translate the user requests into formal queries. The proposed method includes an intelligent dictionary, syntax and semantic verifiers, and a formal query generator. In addition, the proposed system has a learning capability that can improve portability and performance. With the increasing demand for efficient human-machine communication, the significance of this thesis becomes apparent. As human resources become more valuable, software systems that will assist in improving the human-machine interface will be needed and research addressing new solutions will be of utmost importance. This thesis presents an initial design and implementation as a foundation for further research and development into the emerging field of natural language database query systems.

  12. Prize of the best thesis 2015: Study of debris discs through state-of-the-art numerical modelling

    NASA Astrophysics Data System (ADS)

    Kral, Q.; Thébault, P.

    2015-12-01

    This proceeding summarises the thesis entitled ``Study of debris discs with a new generation numerical model'' by Quentin Kral, for which he obtained the prize of the best thesis in 2015. The thesis brought major contributions to the field of debris disc modelling. The main achievement is to have created, almost ex-nihilo, the first truly self-consistent numerical model able to simultaneously follow the coupled collisional and dynamical evolutions of debris discs. Such a code has been thought as being the ``Holy Grail'' of disc modellers for the past decade, and while several codes with partial dynamics/collisions coupling have been presented, the code developed in this thesis, called ``LIDT-DD'' is the first to achieve a full coupling. The LIDT-DD model, which is the first of a new-generation of fully self-consistent debris disc models is able to handle both planetesimals and dust and create new fragments after each collision. The main idea of LIDT-DD development was to merge into one code two approaches that were so far used separately in disc modelling, that is, an N-body algorithm to investigate the dynamics, and a statistical scheme to explore the collisional evolution. This complex scheme is not straightforward to develop as there are major difficulties to overcome: 1) collisions in debris discs are highly destructive and produce clouds of small fragments after each single impact, 2) the smallest (and most numerous) of these fragments have a strongly size-dependent dynamics because of the radiation pressure, and 3) the dust usually observed in discs is precisely these smallest grains. These extreme constraints had so far prevented all previous attempts at developing self-consistent disc models to succeed. The thesis contains many examples of the use of LIDT-DD that are not yet published but the case of the collision between two asteroid-like bodies is studied in detail. In particular, LIDT-DD is able to predict the different stages that should be observed

  13. Identification and removal of trichloroethylene contamination: A case study at Wright-Patterson Air Force Base. Master's thesis

    SciTech Connect

    Butterfield, G.A.

    1991-09-01

    The purpose of this thesis was to determine the parameters associated with installing monitoring wells to detect trichloroethylene contamination, and to determine what emphasis or weights were placed on the nine National Contingency Plan criteria to select a treatment method that would remove trichloroethylene. The results of this study should help installation restoration project officers understand what parameters should be investigated for determining the number and placement of monitoring wells during a remedial investigation for trichloroethylene. The results of this study should also give some insight into what emphasis should be placed on the nine National Contingency Plan criteria.

  14. Multivariable control of the Space Shuttle Remote Manipulator System using linearization by state feedback. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Gettman, Chang-Ching LO

    1993-01-01

    This thesis develops and demonstrates an approach to nonlinear control system design using linearization by state feedback. The design provides improved transient response behavior allowing faster maneuvering of payloads by the SRMS. Modeling uncertainty is accounted for by using a second feedback loop designed around the feedback linearized dynamics. A classical feedback loop is developed to provide the easy implementation required for the relatively small on board computers. Feedback linearization also allows the use of higher bandwidth model based compensation in the outer loop, since it helps maintain stability in the presence of the nonlinearities typically neglected in model based designs.

  15. Guide to implementing reclamation processes at Department of Defense municipal solid waste and construction debris landfills. Master's thesis

    SciTech Connect

    Tures, G.L.

    1993-09-21

    This thesis serves as a guide for implementing landfill reclamation techniques on municipal solid waste or construction debris landfills owned, operated, or used by the DoD. The research describes historical and current methods for disposing of solid waste including open dumping, sanitary landfilling, and the development of state-of-the-art sanitary landfill cell technology. The thesis also identifies the factors which have led to the need for new methods of managing municipal solid waste. The vast majority of the study is devoted to identifying actions which should be taken before, during, and after implementation of a landfill reclamation project. These actions include the development of health, safety, and contingency planning documents, the establishment of systems for characterizing and monitoring site conditions, and the identification of other procedures and processes necessary for performing successful operations. Finally, this study contains a model for analyzing under which conditions reclamation is economically feasible. The model examines economic feasibility in four separate conditions and shows that reclamation is economically feasible in a wide variety of markets. However, the model also shows that feasibility is directly associated with a continuance of normal landfilling operations. Landfill, Landfill reclamation, Landfill mining, Municipal solid waste, Recycling, Construction debris.

  16. [Remarks on Leon Popielski's manuscript of his review of January Zubrzycki's qualifying thesis for professorship dating from 1915].

    PubMed

    Heimrath, T

    1994-01-01

    A review written by professor Leon Popielski from Lvov of the qualifying thesis for professorship of January Zubrzycki from Cracow is presented. The manuscript has been kept by professor Popielski's family. Zubrzycki finished his medical studies in Cracow in 1909. While writing his qualifying thesis entitled Placental Albumin Derivatives and their Toxic Properties in 1915 he was an assistant of Aleksander Rosner in the department of maternity and gynaecology of Jagiellonian University. In 1931 as a professor he became the head of the clinic and following the Second World War he was a professor at several faculties of medicine in Poland. He was an outstanding gynaecological surgeon, an author of a five volume atlas of gynaecological surgery. Professor Leon Popielski studied in S. Petersburg. He specialized in physiology. Since 1904 he was the head of the Chair of Pharmacologoy and Pharmacognosy at the Universitiy of Lvov. Popielski's intrest in Zubrzycki's work ensued his research on albumin metabolite effect. His appreciation of the work is expressed by the phrase "I read it with satisfaction". The review was written in 1919, belated by the war.

  17. Alpha omega alpha election and medical school thesis publication: relationship to subsequent publication rate over a twenty-year period.

    PubMed

    Chusid, M J; Havens, P L; Coleman, C N

    1993-01-01

    To determine the importance of academic and research success during medical school upon subsequent academic activity, a computerized literature search was performed using the names of the 79 surviving members of the Yale Medical School Class of 1970. Individuals elected to Alpha Omega Alpha (AOA) during the third year of school had significantly more publications (mean 101.7 +/- 69.6) between 1970 and 1990 than those elected during the fourth year (mean 28.3 +/- 48.0, p = 0.01). Both had significantly more publications than non-AOA members (mean 11.1 +/- 19.4, p = 0.02). Publication of the student's medical school thesis was also associated with a greater number of publications than thesis non-publication (mean 22.1 +/- 37.5 vs 14.4 +/- 30.0, p = 0.005). These studies demonstrate that, at least at the institution studied, election to AOA and publication of the results of a research project were associated with increased publication rates in the medical field over the 20-year period following medical school graduation.

  18. Ambulatory assessment of skin conductivity during first thesis presentation: lower self-confidence predicts prolonged stress response.

    PubMed

    Elfering, Achim; Grebner, Simone

    2011-06-01

    In this field study self-confidence was tested to predict the course of galvanic electrodermal stress response prior, during and after public speaking. Ten graduate students initially rated their self-confidence and afterwards presented their thesis proposals orally in a 10-min presentation to their supervisor and peers. Galvanic skin response level was measured throughout and analysed for 10 min prior to, during, and 10 min after the presentation. Two major galvanic electrodermal stress response types were observed. Five students showed a 'healthy response', i.e. an anticipatory increase in electrodermal conductance, followed by a decrease after termination of the presentation. The other five students showed a steady increase of skin conductance during and after their presentation ('prolonged response'). In line with the allostatic load model the 'prolonged response' group reported significantly lower self-confidence before presentation than the 'healthy response' group (p < 0.01). Self-confidence is a resource in novices facing an unfamiliar stressor.

  19. Effect on fuel efficiency of parameter variations in the cost function for multivariable control of a turbofan engine. Master's thesis

    SciTech Connect

    Dougherty, B.L.

    1981-09-01

    In modern turbofan engines, variable geometry has been incorporated to improve some off-design performance. Most control designs ignore this variable geometry and use fuel metering as the primary control input. This thesis investigates the use of variable geometry to control the engine and, thereby, reduce fuel consumption due to transients. Additionally, steady-state trim conditions are altered to reduce the static fuel consumption. The non-linear transient simualtion program is used to analyze the steady-state operating condition and develop small perturbation control limitations. Linear models, both large and reduced order, are used in analyzing the effect of controllers on system response. A computer program was generated to reduce a large order linear model to a usable size for control system development. This analysis shows the reduced-order regime dependent controllers to be viable and to favorably enhance the quest for reducing specific fuel consumption in existing engines.

  20. Study of magnetic activity effects on the thermospheric winds in the low ionosphere. Master`s thesis

    SciTech Connect

    Davila, R.C.

    1994-09-01

    The purpose of this thesis is to examine the effects of magnetic activity on the low latitude F-region thermospheric winds. The F-region (120-1600 km) is a partially ionized medium where O+ and O are the major ion and neutral species, respectively. The thermospheric winds at these altitudes are driven primarily by pressure gradient forces resulting from the solar heating during the day and cooling at night. For this study, the author used measured Fabry-Perot Interferometer (FPI) winds at Arequipa (16.5 deg S, 71.5 deg W) and measured FPI and incoherent Scatter Radar (ISR) winds at Arecibo (18.6 deg N, 66.8 deg W).

  1. The application of the reduced order model Kalman filter to motion estimation of degraded image sequences. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Simpson, Elizabeth C.

    1989-01-01

    Motion estimation is a field of great interest because of its many applications in areas such as robotics and image coding. The optic flow method is one such scheme which, although fairly accurate, is prone to error in the presence of noise. This thesis describes the use of the reduced order model Kalman filter (ROMKF) in reducing errors in displacement estimation due to degradation of the sequence. The implementation of filtering and motion estimation algorithms on the SUN workstation is also discussed. Results from preliminary testing were used to determine the degrees of freedom available for the ROMKF in the SUN software. The tests indicated that increasing the state to the left leads to slight improvement over the minimum state case. Therefore, the software uses the minimum model, with the option of adding states to the left only. The ROMKF was then used in conjunction with a hierarchical pel recursive motion estimation algorithm. Applying the ROMKF to the degraded displacements themselves generally yielded slight improvements in cases with noise degradation and noise plus blur. Filtering the images of the degraded sequence prior to motion estimation was less effective in these cases. Both methods performed badly in the case of blur alone, resulting in increased displacement errors. This is thought to be due in part to filter artifacts. Some improvements were obtained by varying the filter parameters when filtering the displacements directly. This result suggests that further study in varying filter parameters may lead to better results. The results of this thesis indicate that the ROMKF can play a part in reducing motion estimation errors from degraded sequences. However, more work needs to be done before the use of the ROMKF can be a practical solution.

  2. Compilation of Thesis Abstracts

    DTIC Science & Technology

    2005-09-01

    Postgraduate School, 2002 Doctor of Philosophy in Electrical Engineering-September 2005 Advisor: Charles W. Therrien , Department of Electrical and Computer...Charles W. Therrien , Department of Electrical and Computer Engineering Signal processing methods for signals sampled at different rates are...OCEAN Joel W. Feldmeier-Lieutenant Commander, United States Navy B.S., Carnegie Mellon University, 1996 M.S., University of Idaho, 2003 Master of

  3. Thesis and Antithesis

    ERIC Educational Resources Information Center

    Baggaley, Jon

    2012-01-01

    Behind every educational concept an opposing notion is waiting for recognition. Despite their avowed objectives, however, academic debates do not always encourage the discussion of opposing views. A review of sessions at the December 2011 Online Educa Conference illustrates that point and others about academic meetings. Opposing viewpoints may be…

  4. Ground support electronic interface for the ionospheric spectroscopy and atmospheric chemistry (ISAAC) ultraviolet spectrograph. Master`s thesis

    SciTech Connect

    MacQuarrie, J.A.

    1994-12-01

    This thesis details the design and development of an electronic Ground Support Equipment (GSE) interface for the Naval Postgraduate School`s (NPS) Ionospheric Spectroscopy and Atmospheric Chemistry (ISAAC) spectrograph. The ISAAC spectrograph, which was designed at NPS and built by Research Support Instruments, Inc., is intended to observe atmospheric airglow and auroral emissions in the ultraviolet (1800A to 3300A) wavelength region. It is to be included as one of several sensors flown onboard the Advanced Research and Global Observation Satellite (ARGOS), which is scheduled for an early 1996 launch. The GSE was developed in order to allow ground testing and calibration of the instrument prior to and during integration with the satellite bus. The GSE includes hardware to provide the connections between various components of the spectrograph and a Macintosh computer with an installed I/O card. The GSE also includes a user-friendly software interface written with LabVIEW 2.2 that provides the ability to view spectra obtained from the instrument and to remotely control mechanical functions of the spectrograph. An initial wavelength calibration of the spectrograph has been performed using the completed GSE.

  5. A large motion zero-gravity suspension system for experimental simulation of orbital construction and deployment. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Straube, Timothy Milton

    1993-01-01

    The design and implementation of a vertical degree of freedom suspension system is described which provides a constant force off-load condition to counter gravity over large displacements. By accommodating motions up to one meter for structures weighing up to 100 pounds, the system is useful for experiments which simulate orbital construction events such as docking, multiple component assembly, or structural deployment. A unique aspect of this device is the combination of a large stroke passive off-load device augmented by electromotive torque actuated force feedback. The active force feedback has the effect of reducing break-away friction by a factor of twenty over the passive system alone. The thesis describes the development of the suspension hardware and the control algorithm. Experiments were performed to verify the suspensions system's effectiveness in providing a gravity off-load and simulating the motion of a structure in orbit. Additionally, a three dimensional system concept is presented as an extension of the one dimensional suspension system which was implemented.

  6. Structure for a knowledge-based system to estimate Soviet tactics in the air-land battle. Master's thesis

    SciTech Connect

    Fletcher, A.M.

    1988-03-01

    The purpose of this thesis was to build a prototype decision aid that can use knowledge about Soviet military doctrine and tactics to infer when, where, and how the Soviet Army plans to attack NATO defenses given intelligence data about Soviet (Red) military units, terrain data, and the positions of the NATO (Blue) defenses. Issues are raised that must be resolved before such a decision aid, which is part of the Rapid Application of Air Power concept, can become operational. First examined is the need to shorten the C2 decision cycle in order for the ATOC staff to keep pace with the tempo of modern warfare. The Rapid Application of Air Power is a concept that includes automating various steps in the decision cycle to allow air power to be applied proactively to stop Soviet forces before they obtain critical objectives. A structure is presented for automating the second step in the decision cycle, assessing and clarifying the situation, through a knowledge-based decision aid for interpreting intelligence data from the perspective of Soviet (Red) doctrine and estimating future Red tactical objectives and maneuvers.

  7. The Elements of an Effective Dissertation and Thesis: A Step-by-Step Guide to Getting it Right the First Time

    ERIC Educational Resources Information Center

    Calabrese, Raymond L.

    2006-01-01

    This is a student guide to writing an effective doctoral dissertation or a master's thesis. This book disaggregates the elements of the dissertation and provides the student with a description, definition, and example of each dissertation element. The author presents multiple viewpoints that include both quantitative and qualitative approaches.…

  8. The Color Lexica of Two American Indian Languages, Quechi and Misquito: A Critical Contribution to the Application of the Whorf Thesis to Color Naming

    ERIC Educational Resources Information Center

    von Wattenwyl, Andre; Zollinger, Heinrich

    1978-01-01

    Studies the link between the theory of the neurophysiology of color perception and Berlin and Kay's ideas on color linguistics and color perception. Two interpretations of studies of color terminology are shown, one supporting and one disproving the Whorf Thesis. (NCR)

  9. Revealing Future Research Capacity from an Analysis of a National Database of Discipline-Coded Australian PhD Thesis Records

    ERIC Educational Resources Information Center

    Pittayachawan, Siddhi; Macauley, Peter; Evans, Terry

    2016-01-01

    This article reports how statistical analyses of PhD thesis records can reveal future research capacities for disciplines beyond their primary fields. The previous research showed that most theses contributed to and/or used methodologies from more than one discipline. In Australia, there was a concern for declining mathematical teaching and…

  10. The Hematologic Definition of Monoclonal Gammopathy of Undetermined Significance in Relation to Paraproteinemic Keratopathy (An American Ophthalmological Society Thesis)

    PubMed Central

    Lisch, Walter; Wasielica-Poslednik, Joanna; Kivelä, Tero; Schlötzer-Schrehardt, Ursula; Rohrbach, Jens M.; Sekundo, Walter; Pleyer, Uwe; Lisch, Christina; Desuki, Alexander; Rossmann, Heidi; Weiss, Jayne S.

    2016-01-01

    Purpose To determine if paraproteinemic keratopathy (PPK) in the setting of monoclonal gammopathy of undetermined significance (MGUS) causes distinct patterns of corneal opacification that can be distinguished from hereditary, immunologic, or inflammatory causes. Methods A retrospective, interventional study of patients showed distinct bilateral opacity patterns of the cornea at the eye clinics of Hanau, Mainz, Helsinki, Marburg, and Berlin between 1993 and 2015. Data on patient characteristics and clinical features on ophthalmic examination were collected, and serum protein profiles were evaluated. A literature review and analysis of all published studies of MGUS with PPK is also presented. Results The largest group of patients diagnosed with MGUS-induced PPK is analyzed in this study. We studied 22 eyes of 11 patients (6 male, aged 43 to 65, mean age 54; 5 female, aged 49 to 76, mean age 61) with distinct corneal opacities and visual impairment who were first suspected of having hereditary, inflammatory, or immunologic corneal entities. Subsequently, serum protein electrophoresis revealed MGUS to be the cause of the PPK. Literature review revealed 72 patients with bilateral PPK (34 male, mean age 57; 38 female, mean age 58) in 51 studies of MGUS published from 1934 to 2015 and disclosed six additional corneal opacity patterns. Conclusions This thesis shows that MGUS is not always an asymptomatic disorder, in contrast to the hematologic definition, which has no hint of PPK. The MGUS-induced PPK can mimic many other diseases of the anterior layer of the eye. A new clinical classification for PPK in MGUS is proposed. PMID:28050052

  11. A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans with PTSD

    DTIC Science & Technology

    2015-10-01

    Dieter J. Meyerhoff, Dr.rer.nat., UCSF Rationale and Content: Civilian and military personnel with posttraumatic stress disorder (PTSD) frequently...observed in both Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) and is associated with worse treatment outcome. Impairment in...CA 94121 Purpose: Cognitive dysfunction is commonly observed among individuals with Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder

  12. The Accuracy of Parameter Estimation in System Identification of Noisy Aircraft Load Measurement. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Kong, Jeffrey

    1994-01-01

    This thesis focuses on the subject of the accuracy of parameter estimation and system identification techniques. Motivated by a complicated load measurement from NASA Dryden Flight Research Center, advanced system identification techniques are needed. The objective of this problem is to accurately predict the load experienced by the aircraft wing structure during flight determined from a set of calibrated load and gage response relationship. We can then model the problem as a black box input-output system identification from which the system parameter has to be estimated. Traditional LS (Least Square) techniques and the issues of noisy data and model accuracy are addressed. A statistical bound reflecting the change in residual is derived in order to understand the effects of the perturbations on the data. Due to the intrinsic nature of the LS problem, LS solution faces the dilemma of the trade off between model accuracy and noise sensitivity. A method of conflicting performance indices is presented, thus allowing us to improve the noise sensitivity while at the same time configuring the degredation of the model accuracy. SVD techniques for data reduction are studied and the equivalence of the Correspondence Analysis (CA) and Total Least Squares Criteria are proved. We also looked at nonlinear LS problems with NASA F-111 data set as an example. Conventional methods are neither easily applicable nor suitable for the specific load problem since the exact model of the system is unknown. Neural Network (NN) does not require prior information on the model of the system. This robustness motivated us to apply the NN techniques on our load problem. Simulation results for the NN methods used in both the single load and the 'warning signal' problems are both useful and encouraging. The performance of the NN (for single load estimate) is better than the LS approach, whereas no conventional approach was tried for the 'warning signals' problems. The NN design methodology is also

  13. Measurements of production cross sections of 10Be and 26Al by 120 GeV and 392 MeV proton bombardment of 89Y, 159Tb, and natCu targets

    SciTech Connect

    Sekimoto, S.; Okumura, S.; Yashima, H.; Matsushi, Y.; Matsuzaki, H.; Matsumura, H.; Toyoda, A.; Oishi, K.; Matsuda, N.; Kasugai, Y.; Sakamoto, Y.; Nakashima, H.; Boehnlein, D.; Coleman, R.; Lauten, G.; Leveling, A.; Mokhov, N.; Ramberg, E.; Soha, A.; Vaziri, K.; Ninomiya, K.; Omoto, T.; Shima, T.; Takahashi, N.; Shinohara, A.; Caffee, M. W.; Welten, K. C.; Nishiizumi, K.; Shibata, S.; Ohtsuki, T.

    2015-08-12

    The production cross sections of 10Be and 26Al were measured by accelerator mass spectrometry using 89Y, 159Tb, and natCu targets bombarded by protons with energies Ep of 120 GeV and 392 MeV. The production cross sections obtained for 10Be and 26Al were compared with those previously reported using Ep = 50 MeV–24 GeV and various targets. It was found that the production cross sections of 10Be monotonically increased with increasing target mass number when the proton energy was greater than a few GeV. On the other hand, it was also found that the production cross sections of 10Be decreased as the target mass number increased from that of carbon to those near the mass numbers of nickel and zinc when the proton energy was below approximately 1 GeV. They also increased as the target mass number increased from near those of nickel and zinc to that of bismuth, in the same proton energy range. Similar results were observed in the production cross sections of 26Al, though the absolute values were quite different between 10Be and 26Al. As a result, the difference between these production cross sections may depend on the impact parameter (nuclear radius) and/or the target nucleus stiffness.

  14. Flame Front Propagation and Finger Competition and Formation of a Single Saffman-Taylor Finger without Surface Tension - PhD Thesis

    NASA Astrophysics Data System (ADS)

    Kupervasser, Oleg

    2003-02-01

    Problems of interface growth have received much attention recently Such are, for example, the duffusion limited aggregation (DLA), random sequential adsorption (RSA), Laplacian growth or flame front propagation. We will mainly pay attention in this Thesis to the numerical and analytical investigation of the last two problems. In addition to the fact that flame front propagation is an interesting physical problem we feel that we can also explain experimental results on the basis of theoretical investigations. There exists possibility to use methods found for the flame front propagation, in different fields where similar problems appear such as the important model of Laplacian growth .

  15. DHA supplementation for late onset Stargardt disease: NAT-3 study

    PubMed Central

    Querques, Giuseppe; Benlian, Pascale; Chanu, Bernard; Leveziel, Nicolas; Coscas, Gabriel; Soubrane, Gisele; Souied, Eric H

    2010-01-01

    Background: We analyzed the effects of a docosahexaenoic acid (DHA) supplementation in patients affected with late onset Stargardt disease (STGD). Methods: DHA (840 mg/day) was given to 20 STGD patients for six months. A complete ophthalmologic examination, including best-corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG), was performed at inclusion day 0 (D0) and at month 6 (M6). Results: Overall, no statistical differences have been observed at M6 vs D0 as regards BCVA and mfERG (P > 0.05). Mild Improvement of BCVA and improvement of mfERG was noted in seven/40 eyes of four/20 patients. In the first patient, the peak of the a wave increased from 66 nV/deg2 to 75.4 nV/deg2 in the right eye (RE) and 24.5 nV/deg2 to 49.1 nV/deg2 in the left eye (LE). The peak of the b wave improved from 122 nV/deg2 to 157 nV/deg2 in the RE, and 102 nV/deg2 to 149 nV/deg2 in the LE. In the second patient peaks of the a and b waves respectively increased from 11.8 nV/deg2 to 72.1 nV/deg2 and 53 nV/deg2 to 185 nV/deg2 in the RE. In the third patient the peak of the a wave increased from 37 nV/deg2 to 43 nV/deg2 in the RE, and from 31 nV/deg2 to 45 nV/deg2 in the LE; the peak of the b wave improved from 70 nV/deg2 to 89 nV/deg2 in the RE, and from 101 nV/deg2 to 108 nV/deg2 in the LE. In the fourth patient, the peak of the a wave increased from 39 nV/deg2 to 42 nV/deg2 in the RE, and from 40 nV/deg2 to 43 nV/deg2 in the LE; the peak of the b wave improved from 86 nV/deg2 to 94 nV/deg2 in the RE, and from 87 nV/deg2 to 107 nV/deg2 in the LE. Conclusion: DHA seems to influence some functional parameters in patients affected with STGD. However, no short-term benefit should be expected from DHA supplementation. PMID:20668719

  16. Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

    PubMed

    Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C

    2016-07-01

    André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.

  17. On developing a thesis for Reproductive Endocrinology and Infertility fellowship: a case study of ultra-low (2%) oxygen tension for extended culture of human embryos.

    PubMed

    Kaser, Daniel J

    2017-03-01

    Fellows in Reproductive Endocrinology and Infertility training are expected to complete 18 months of clinical, basic, or epidemiological research. The goal of this research is not only to provide the basis for the thesis section of the oral board exam but also to spark interest in reproductive medicine research and to provide the next generation of physician-scientists with a foundational experience in research design and implementation. Incoming fellows often have varying degrees of training in research methodology and, likewise, different career goals. Ideally, selection of a thesis topic and mentor should be geared toward defining an "answerable" question and building a practical skill set for future investigation. This contribution to the JARG Young Investigator's Forum revisits the steps of the scientific method through the lens of one recently graduated fellow and his project aimed to test the hypothesis that "sequential oxygen exposure (5% from days 1 to 3, then 2% from days 3 to 5) improves blastocyst yield and quality compared to continuous exposure to 5% oxygen among human preimplantation embryos."

  18. Numerical Prediction of Turbulent Oscillating Flow and Heat Transfer in Pipes with Various End Geometries. Ph.D. Thesis, Final Report

    NASA Technical Reports Server (NTRS)

    Oseid, Kirk Leroi

    1995-01-01

    Unsteady flow is present in man, machine and nature. The flow of blood in arteries and capillaries in the human body is pulsatile-composed of a mean flow superposed with an oscillating component. The tides that wash in and out of rivers, harbors and estuaries are unsteady flows with very long periods of oscillation. Many engineering devices employ pulsatile and oscillating flow. Pulsating flow is defined here as a periodic flow with a net displacement of fluid over each flow cycle. Oscillating flow is defined as a period flow with a zero mean over each cycle. The subject of this thesis is oscillating flow and heat transfer in pipes which make up the heater and cooler sections of the NASA Space Power Research Engine (SPRE) currently under development. This engine uses the Stirling cycle as the thermal energy converter in a power plant for future space applications. The information presented in this thesis will of course be applicable to the design of many types of machinery which employ oscillating flow and heat transfer.

  19. BETA: Behavioral testability analyzer and its application to high-level test generation and synthesis for testability. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Chen, Chung-Hsing

    1992-01-01

    In this thesis, a behavioral-level testability analysis approach is presented. This approach is based on analyzing the circuit behavioral description (similar to a C program) to estimate its testability by identifying controllable and observable circuit nodes. This information can be used by a test generator to gain better access to internal circuit nodes and to reduce its search space. The results of the testability analyzer can also be used to select test points or partial scan flip-flops in the early design phase. Based on selection criteria, a novel Synthesis for Testability approach call Test Statement Insertion (TSI) is proposed, which modifies the circuit behavioral description directly. Test Statement Insertion can also be used to modify circuit structural description to improve its testability. As a result, Synthesis for Testability methodology can be combined with an existing behavioral synthesis tool to produce more testable circuits.

  20. Checkpoint-based forward recovery using lookahead execution and rollback validation in parallel and distributed systems. Ph.D. Thesis, 1992

    NASA Technical Reports Server (NTRS)

    Long, Junsheng

    1994-01-01

    This thesis studies a forward recovery strategy using checkpointing and optimistic execution in parallel and distributed systems. The approach uses replicated tasks executing on different processors for forwared recovery and checkpoint comparison for error detection. To reduce overall redundancy, this approach employs a lower static redundancy in the common error-free situation to detect error than the standard N Module Redundancy scheme (NMR) does to mask off errors. For the rare occurrence of an error, this approach uses some extra redundancy for recovery. To reduce the run-time recovery overhead, look-ahead processes are used to advance computation speculatively and a rollback process is used to produce a diagnosis for correct look-ahead processes without rollback of the whole system. Both analytical and experimental evaluation have shown that this strategy can provide a nearly error-free execution time even under faults with a lower average redundancy than NMR.

  1. Computational strategies for three-dimensional flow simulations on distributed computer systems. Ph.D. Thesis Semiannual Status Report, 15 Aug. 1993 - 15 Feb. 1994

    NASA Technical Reports Server (NTRS)

    Weed, Richard Allen; Sankar, L. N.

    1994-01-01

    An increasing amount of research activity in computational fluid dynamics has been devoted to the development of efficient algorithms for parallel computing systems. The increasing performance to price ratio of engineering workstations has led to research to development procedures for implementing a parallel computing system composed of distributed workstations. This thesis proposal outlines an ongoing research program to develop efficient strategies for performing three-dimensional flow analysis on distributed computing systems. The PVM parallel programming interface was used to modify an existing three-dimensional flow solver, the TEAM code developed by Lockheed for the Air Force, to function as a parallel flow solver on clusters of workstations. Steady flow solutions were generated for three different wing and body geometries to validate the code and evaluate code performance. The proposed research will extend the parallel code development to determine the most efficient strategies for unsteady flow simulations.

  2. Authority of states of use section 401 water quality certification to deny or condition Federal Energy Regulatory Commission licenses. Master's thesis

    SciTech Connect

    Hart, E.O.

    1994-09-01

    This thesis discusses a recent United States Supreme Court case that will have a profound influence on the licensure of hydroelectric projects and the related ability of States to protect the quality of their waters. On October 4, 1993, the Supreme Court granted a Writ of Certiorari to resolve a conflict among the state courts of last resort. This case involves two fundamental and competing national interests: the nation's thirst for cheap, dependable power versus its equally strong desire to improve the quality of its water resources. It also involves two underlying regulatory regimes that overlap and conflict with each other in some ways. This case illustrates how those two national interests and their underlying regulatory regimes cannot always be reconciled. It also demonstrates how Congress, with its muddled ways of passing legislation, can create conflicts between federal and state regulatory agencies.

  3. An Innovative, Multidisciplinary Educational Program in Interactive Information Storage and Retrieval. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Gallagher, Mary C.

    1985-01-01

    There exists a large number of large-scale bibliographic Information Storage and Retrieval Systems containing large amounts of valuable data of interest in a wide variety of research applications. These systems are not used to capacity because the end users, i.e., the researchers, have not been trained in the techniques of accessing such systems. This thesis describes the development of a transportable, university-level course in methods of querying on-line interactive Information Storage and Retrieval systems as a solution to this problem. This course was designed to instruct upper division science and engineering students to enable these end users to directly access such systems. The course is designed to be taught by instructors who are not specialists in either computer science or research skills. It is independent of any particular IS and R system or computer hardware. The project is sponsored by NASA and conducted by the University of Southwestern Louisiana and Southern University.

  4. Analysis of the effects of ionospheric sampling of reflection points near-path, for high-frequency single-site-location direction finding systems. Master's thesis

    SciTech Connect

    Filho, C.A.

    1990-12-01

    This thesis suggests a method to estimate the current value of an ionospheric parameter. The proposed method is based on the known variability of the observed current values near path and utilizes data derived from ionospheric sampling measurements. Analysis of errors is provided in Single-Site-Location High-Frequency Direction Finding (SSL-HFDF), arising from ionospheric irregularities such as Es (sporadic E), ionospheric tilts, and traveling ionospheric disturbances (TIDs). The characteristics of Es, tilts and TIDs for mid-latitudes are summarized in tables. The spatial and temporal coherence of ionospheric variabilities and irregularities is analyzed over the electron density. Practical results, measurements, and studies are presented on SSL-HFDF. A survey of characteristics of the ionosphere in the equatorial region is also provided. Finally, some recommendations are given to maximize the applicability of the proposed method.

  5. Biomedical conflicts of interest: a defence of the sequestration thesis-learning from the cases of Nancy Olivieri and David Healy.

    PubMed

    Schafer, A

    2004-02-01

    No discussion of academic freedom, research integrity, and patient safety could begin with a more disquieting pair of case studies than those of Nancy Olivieri and David Healy. The cumulative impact of the Olivieri and Healy affairs has caused serious self examination within the biomedical research community. The first part of the essay analyses these recent academic scandals. The two case studies are then placed in their historical context-that context being the transformation of the norms of science through increasingly close ties between research universities and the corporate world. After a literature survey of the ways in which corporate sponsorship has biased the results of clinical drug trials, two different strategies to mitigate this problem are identified and assessed: a regulatory approach, which focuses on managing risks associated with industry funding of university research, and a more radical approach, the sequestration thesis, which counsels the outright elimination of corporate sponsorship. The reformist approach is criticised and the radical approach defended.

  6. Thesis Handling in University Libraries

    ERIC Educational Resources Information Center

    Patterson, Kelly; And Others

    1977-01-01

    Libraries of ninety universities granting doctorates were surveyed regarding binding, cataloging, classification, storage and checking of format practices for theses and dissertations. Recommended processing practice involves full descriptive and subject cataloging with author input on the latter point, and the elimination of all but the most…

  7. Readers, Writers and Thesis Distribution.

    ERIC Educational Resources Information Center

    Weltzien, O. Alan

    Most freshman composition textbooks promote one discourse structure, usually stressing early placement of the points of an essay. This can lock rapidly changing writers into composing according to only one format. In addition, adhering to a prescribed structure rather than focusing on meaning too often causes structure--not meaning--to control the…

  8. Politics of NATO short-range nuclear modernization 1983-1990: The follow-on-to-Lance missile decisions. Doctoral thesis

    SciTech Connect

    Larsen, J.A.

    1991-06-01

    The follow-on to Lance (FOTL) missile was born in 1983 with a consensual decision by NATO, in the face of a worsening strategic situation, to pursue short-range nuclear force (SNF) modernization. The program continued despite increasing popular and political opposition in Europe. It ended with a May 1990 cancellation decision by the American bureaucracy that reflected converging pressures from the international system, from America's allies, and from the domestic arena. The thesis attempts to answer each question through the use of one of three analytical perspectives: systemic theory, alliance politics, or domestic politics. It concludes that during this time of diminishing threat at the systemic level, domestic-level factors within the German and American milieu became more important. While certain perspectives are better at explaining particular aspects or temporal periods of modernization cases, analysts should not focus on one perspective to the exclusion of others. Unexplained residual variables fall through the filter of each perspective, calling for further study by other approaches.

  9. Systems engineering approach to environmental risk management: A case study of depleted uranium at test area C-64, Eglin Air Force Base, Florida. Master`s thesis

    SciTech Connect

    Carter, C.M.; Fortmann, K.M.; Hill, S.W.; Latin, R.M.; Masterson, E.J.

    1994-12-01

    Environmental restoration is an area of concern in an environmentally conscious world. Much effort is required to clean up the environment and promote environmentally sound methods for managing current land use. In light of the public consciousness with the latter topic, the United States Air Force must also take an active role in addressing these environmental issues with respect to current and future USAF base land use. This thesis uses the systems engineering technique to assess human health risks and to evaluate risk management options with respect to depleted uranium contamination in the sampled region of Test Area (TA) C-64 at Eglin Air Force Base (AFB). The research combines the disciplines of environmental data collection, DU soil concentration distribution modeling, ground water modeling, particle resuspension modeling, exposure assessment, health hazard assessment, and uncertainty analysis to characterize the test area. These disciplines are required to quantify current and future health risks, as well as to recommend cost effective ways to increase confidence in health risk assessment and remediation options.

  10. Responsible soldiering in the nuclear age: inferences from the Catholic Bishop's Pastoral on nuclear war. Master's thesis, August 1985-June 1986

    SciTech Connect

    Smith, M.E.

    1986-06-06

    This thesis is an attempt to develop an ethic for those who must perform soldierly duties in this era. It is an examination of core values, and how these values have been translated into military ethics and obligations within the context of western civilization. This study uses the most recent application of just-war theory, the Catholic Bishop's Pastoral on nuclear war, The Challenge of Peace: God's Promise and Our Response, and compares its instruction to selected findings of another contemporary application, the Nuremberg War Trials. The manner in which we construct and reinforce our moral values in conscience, coupled with appreciation for the sanctity of human existence, evolve as fundamental underlying principles. After having established the scope of authority from which the Catholic Bishop's Pastoral derives its credibility, these principles are compared against the United States Army Ethic and a contemporary ethic is proposed. The study concludes that ultimately we are responsible for the decisions and choices that we make. Soldiers are not absolved, especially within the Judeo-Christian context, from the obligation to make choices based upon sound moral reasoning, simply because they are engaged in activities that run counter to orderly human existence.

  11. Power recovery of radiation damaged MOCVD grown indium phosphide on silicon solar cells through argon-ion laser annealing. Master`s thesis

    SciTech Connect

    Boyer, L.L.

    1996-06-01

    This thesis reports the results of a laser annealing technique used to remove defect sites from radiation damaged indium phosphide on silicon MOCVD grown solar cells. This involves the illumination of damaged solar cells with a continuous wave laser to produce a large forward-biased current. The InP/Si cells were irradiated with 1 MeV electrons to a given fluence, and tested for degradation. Light from an argon laser was used to illuminate four cells with an irradiance of 2.5 W/sq cm, producing a current density 3 to 5 times larger than AMO conditions. Cells were annealed at 19 deg C with the laser and at 25 deg C under AMO conditions. Annealing under laser illumination of n/p-type cells resulted in recovery of 48%. P/n type cells lost 4 to 12% of the assumed degradaton. Annealing under AMO conditions resulted in power recovery of 70% in n/p type cells. P/n-type cells recovered approximately 16% of lost power. Results indicate that significant power recovery results from the annealing of defects within n/p type InP/Si solar cells.

  12. Molecular dynamics simulation of a piston driven shock wave in a hard sphere gas. Final Contractor ReportPh.D. Thesis

    NASA Technical Reports Server (NTRS)

    Woo, Myeung-Jouh; Greber, Isaac

    1995-01-01

    Molecular dynamics simulation is used to study the piston driven shock wave at Mach 1.5, 3, and 10. A shock tube, whose shape is a circular cylinder, is filled with hard sphere molecules having a Maxwellian thermal velocity distribution and zero mean velocity. The piston moves and a shock wave is generated. All collisions are specular, including those between the molecules and the computational boundaries, so that the shock development is entirely causal, with no imposed statistics. The structure of the generated shock is examined in detail, and the wave speed; profiles of density, velocity, and temperature; and shock thickness are determined. The results are compared with published results of other methods, especially the direct simulation Monte-Carlo method. Property profiles are similar to those generated by direct simulation Monte-Carlo method. The shock wave thicknesses are smaller than the direct simulation Monte-Carlo results, but larger than those of the other methods. Simulation of a shock wave, which is one-dimensional, is a severe test of the molecular dynamics method, which is always three-dimensional. A major challenge of the thesis is to examine the capability of the molecular dynamics methods by choosing a difficult task.

  13. Cost-benefit analysis of implementing an aluminum and tin recycling program onboard United States Naval Combatants. Master`s thesis

    SciTech Connect

    Devinney, E.W.

    1995-12-01

    This thesis analyzes the financial feasibility of implementing a recycling program onboard U.S. Naval Combatants. This study focuses primarily on revenues generated from the sale of aluminum and tin, as they compose the most significant portions of a ship`s recyclable waste stream. Specific factors investigated include storage limitations, sanitation concerns, manpower issues, cost constraints, lack of training, lack of incentives, tangible benefits, and perceived benefits. Usage data for both tin and aluminum were gathered from each ship type to determine required storage volumes and potential revenues from the sale of the recyclables. A thorough space inspection was conducted of each ship type to ascertain potential storage spaces and their suitability for temporary storage while underway. Specific findings are that there is adequate storage room aboard these ships, that crews` quality of life will not be sacrificed, and that there exists potential for significant revenues by selling the recyclable cans, all of which are retained by the ship. More generally, it is shown that it is cost-effective to implement an aluminum and tin recycling program onboard U.S. Naval Combatants.

  14. Acquisition and production of skilled behavior in dynamic decision-making tasks. Semiannual Status Report M.S. Thesis - Georgia Inst. of Tech., Nov. 1992

    NASA Technical Reports Server (NTRS)

    Kirlik, Alex; Kossack, Merrick Frank

    1993-01-01

    This status report consists of a thesis entitled 'Ecological Task Analysis: A Method for Display Enhancements.' Previous use of various analysis processes for the purpose of display interface design or enhancement has run the risk of failing to improve user performance due to the analysis resulting in only a sequencial listing of user tasks. Adopting an ecological approach to performing the task analysis, however, may result in the necessary modeling of an unpredictable and variable task domain required to improve user performance. Kirlik has proposed an Ecological Task Analysis framework which is designed for this purpose. It is the purpose of this research to measure this framework's effectiveness at enhancing display interfaces in order to improve user performance. Following the proposed framework, an ecological task analysis of experienced users of a complex and dynamic laboratory task, Star Cruiser, was performed. Based on this analysis, display enhancements were proposed and implemented. An experiment was then conducted to compare this new version of Star Cruiser to the original. By measuring user performance at different tasks, it was determined that during early sessions, use of the enhanced display contributed to better user performance compared to that achieved using the original display. Furthermore, the results indicate that the enhancements proposed as a result of the ecological task analysis affected user performance differently depending on whether they are enhancements which aid in the selection of a possible action or in the performance of an action. Generalizations of these findings to larger, more complex systems were avoided since the analysis was only performed on this one particular system.

  15. Spectral Domain Optical Coherence Tomography in Glaucoma: Qualitative and Quantitative Analysis of the Optic Nerve Head and Retinal Nerve Fiber Layer (An AOS Thesis)

    PubMed Central

    Chen, Teresa C.

    2009-01-01

    Purpose: To demonstrate that video-rate spectral domain optical coherence tomography (SDOCT) can qualitatively and quantitatively evaluate optic nerve head (ONH) and retinal nerve fiber layer (RNFL) glaucomatous structural changes. To correlate quantitative SDOCT parameters with disc photography and visual fields. Methods: SDOCT images from 4 glaucoma eyes (4 patients) with varying stages of open-angle glaucoma (ie, early, moderate, late) were qualitatively contrasted with 2 age-matched normal eyes (2 patients). Of 61 other consecutive patients recruited in an institutional setting, 53 eyes (33 patients) met inclusion/exclusion criteria for quantitative studies. Images were obtained using two experimental SDOCT systems, one utilizing a superluminescent diode and the other a titanium:sapphire laser source, with axial resolutions of about 6 μm and 3 μm, respectively. Results: Classic glaucomatous ONH and RNFL structural changes were seen in SDOCT images. An SDOCT reference plane 139 μm above the retinal pigment epithelium yielded cup-disc ratios that best correlated with masked physician disc photography cup-disc ratio assessments. The minimum distance band, a novel SDOCT neuroretinal rim parameter, showed good correlation with physician cup-disc ratio assessments, visual field mean deviation, and pattern standard deviation (P values range, .0003–.024). RNFL and retinal thickness maps correlated well with disc photography and visual field testing. Conclusions: To our knowledge, this thesis presents the first comprehensive qualitative and quantitative evaluation of SDOCT images of the ONH and RNFL in glaucoma. This pilot study provides basis for developing more automated quantitative SDOCT-specific glaucoma algorithms needed for future prospective multicenter national trials. PMID:20126502

  16. Die Aufnahme partikulärer Nahrung bei Reniera sp. (Porifera)

    NASA Astrophysics Data System (ADS)

    Langenbruch, Paul-Friedrich

    1985-09-01

    The choanocyte chambers of the marine sponge Reniera sp. protrude with their curved outer surface free into the incurrent canals. The water is sucked into the chambers by cavities between the choanocytes. Particles up to 1 µm in diameter may enter the chambers with the water current. These particles are trapped on the outer surface of the choanocyte collars and are ingested by the choanocytes and processes of the pinacocyte epithelium of the incurrent canal system, which project into the chambers. Bigger particles are retained in the incurrent canals mainly on the outer surface of the choanocyte chambers. They are ingested by pinacocytes of the canal wall and transported to cells of the mesenchyme. The present investigation shows the great importance of the pinacocyte epithelium of the incurrent canal system for suspension feeding in Reniera sp.

  17. Diverticulite duodénale: complication inhabituelle pas toujours facile à gérer

    PubMed Central

    Elhjouji, Abderrahman; Jaiteh, Lamine; Bounaim, Ahmed; Aitali, Abdelmounaim; Sair, Khalid

    2015-01-01

    Les diverticules duodénaux sont assez fréquents, la majorité reste asymptomatique. Les complications les plus fréquemment rapportées sont les hémorragies et les pancréatites. Contrairement aux diverticules coliques, la survenue de diverticulite est rare. Nous rapportons le cas d'une infection d'un gros diverticule duodénal en mettant le point sur la difficulté de la prise en charge de cette entité pathologique. PMID:26958122

  18. Measurements of the Total Reaction Cross Sections for 6,8He and 8,9Li Nuclei with Energies of (25-45)A Mev on natAl, natTa and natPb

    NASA Astrophysics Data System (ADS)

    Erdemchimeg, B.; Artukh, A. G.; Klygin, S. A.; Kononenko, G. A.; Kyslukha, D. A.; Sereda, Yu. M.; Vorontzov, A. N.; Lukyanov, S. M.; Penionzhkevich, Yu. E.; Davaa, S.; Khuukhenkhuu, G.; Borcea, C.; Rotaru, F.; Stanoiu, M.; Martina, L.; Saillant, F.; Raine, B.

    2015-06-01

    The total nuclear reaction cross sections (σR) measurements have long been of interest since they tell us about the radii and transparency of these nuclei and give clues to understanding of their structure. For studies of unstable nuclei, in particular the physical properties of halo nuclei and the neutron skin thickness, it is valuable to know not only the root-mean-square radii (rms) but it is important to know the details of nucleusnucleus potentials. Our goal was to study total reaction cross sections (σR) by a direct measurement technique (the so-called beam attenuation or transmission method) which allows to extract model independent information. The interaction radii for 6He, 8,9Li were extracted, which are in agreement with the previous measurement at the similar energies (about a few tens of AMeV) Our results show a tendency of increasing radii as function of mass of the secondary targets.

  19. Soviet Computers and Cybernetics: Shortcomings and Military Applications.

    DTIC Science & Technology

    1980-06-01

    Soviet Military Decision Making, Thesis (Delivered to the Ninth National Conference of the American Association for the Advancement of Slavic Studies , October...Thesis. Ninth NatLonal Conference of the American Association for the Advancement of Slavic Studies , October 1978. Myagi, A. "Problemi khozrascheta VTs

  20. The Design of PC/MISI, a PC-Based Common User Interface to Remote Information Storage and Retrieval Systems. M.S. ThesisFinal Report, 1 Jul. 1985 - 31 Dec. 1987

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    The amount of information contained in the data bases of large-scale information storage and retrieval systems is very large and growing at a rapid rate. The methods available for assessing this information have not been successful in making the information easily available to the people who have the greatest need for it. This thesis describes the design of a personal computer based system which will provide a means for these individuals to retrieve this data through one standardized interface. The thesis identifies each of the major problems associated with providing access to casual users of IS and R systems and describes the manner in which these problems are to be solved by the utilization of the local processing power of a PC. Additional capabilities, not available with standard access methods, are also provided to improve the user's ability to make use of this information. The design of PC/MISI is intended to facilitate its use as a research vehicle. Evaluation mechanisms and possible areas of future research are described. The PC/MISI development effort is part of a larger research effort directed at improving access to remote IS and R systems. This research effort, supported in part by NASA, is also reviewed.

  1. MATERNAL SMOKING DURING PREGNANCY, GENETIC VARIATION OF ACETYL-N-TRANSFERASES NAT1 AND NAT2, AND RISK FOR OROFACIAL CLEFTS. (R828292)

    EPA Science Inventory

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  2. A systems analysis of the impact of navigation instrumentation on-board a Mars rover, based on a covariance analysis of navigation performance. M.S. Thesis, Massachusetts Inst. of Technology

    NASA Technical Reports Server (NTRS)

    Leber, Douglas Eric

    1992-01-01

    As part of the Space Exploration Initiative, the exploration of Mars will undoubtedly require the use of rovers, both manned and unmanned. Many mission scenarios have been developed, incorporating rovers which range in size from a few centimeters to ones large enough to carry a manned crew. Whatever the mission, accurate navigation of the rover on the Martian surface will be necessary. This thesis considers the initial rover missions, where minimal in-situ navigation aids will be available on Mars. A covariance analysis of the rover's navigation performance is conducted, assuming minimal on-board instrumentation (gyro compass and speedometer), a single orbiting satellite, and a surface beacon at the landing site. Models of the on-board instruments are varied to correspond to the accuracy of various levels of these instruments currently available. A comparison is made with performance of an on-board IMU. Landing location and satellite orbits are also varied.

  3. Fighter agility metrics. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Liefer, Randall K.

    1990-01-01

    Fighter flying qualities and combat capabilities are currently measured and compared in terms relating to vehicle energy, angular rates and sustained acceleration. Criteria based on these measurable quantities have evolved over the past several decades and are routinely used to design aircraft structures, aerodynamics, propulsion and control systems. While these criteria, or metrics, have the advantage of being well understood, easily verified and repeatable during test, they tend to measure the steady state capability of the aircraft and not its ability to transition quickly from one state to another. Proposed new metrics to assess fighter aircraft agility are collected and analyzed. A framework for classification of these new agility metrics is developed and applied. A complete set of transient agility metrics is evaluated with a high fidelity, nonlinear F-18 simulation. Test techniques and data reduction methods are proposed. A method of providing cuing information to the pilot during flight test is discussed. The sensitivity of longitudinal and lateral agility metrics to deviations from the pilot cues is studied in detail. The metrics are shown to be largely insensitive to reasonable deviations from the nominal test pilot commands. Instrumentation required to quantify agility via flight test is also considered. With one exception, each of the proposed new metrics may be measured with instrumentation currently available.

  4. Utilization of coal fly ash. Master's thesis

    SciTech Connect

    Openshaw, S.C.

    1992-01-01

    Coal-fired power plants produce approximately 80 million tons of fly ash each year. Efforts to use fly ash have reached only a twenty to thirty percent reutilization rate. A literature review was performed to provide a consensus of the available information regarding fly ash. Fly ash is highly variable depending on the coal source, plant operations, and several other parameters. The various fly ash characteristics are discussed including classifications, physical characteristics, chemical properties and chemical compositions. Although extensive research has been performed on the use of fly ash, very little of this research has monitored any environmental impacts. The environmental concerns addressed include mobilization of toxic elements, biota impact, microbial impact, handling dangers, and pertinent regulations. Finally, the various disposal and reutilization options for fly ash are examined. A recommendation is provided for further research to cover deficiencies found in the literature.

  5. Solar energy and the aeronautics industry. Thesis

    NASA Technical Reports Server (NTRS)

    Benedek, L.

    1985-01-01

    An introduction to the physical aspects of solar energy, incidental energy and variations in solar flux is presented, along with an explanation of the physical principles of obtaining solar energy. The history of the application of solar energy to aeronautics, including the Gossamer Penguin and the Solar Challenger is given. Finally, an analysis of the possibilities of using a reaction motor with hybrid propulsion combining solar energy with traditional fuels as well as calculations of the proposed cycle and its mode of operation are given.

  6. Limited antiballistic missile system. Master's thesis

    SciTech Connect

    Payne, J.H.

    1990-12-01

    This investigation examines the possibilities of deploying a limited ABM system to counter launches from Third World regions. It is a systems analysis of the entire concept, with the objective of determining if the existing missile warning network could detect launches from Third World regions, and if an ABM component could be integrated into the network. A computer model was used to determine if launches would be detected, and examine the warning time provided. Based on sample data, the warning network appears capable of detecting Third World launches. Warning times provided by the network appears to provide adequate time to communicate the event up through the National Command Authorities, and launch an interceptor. The ABM structure could be integrated into the existing network, using the unified command currently operating it. The entire US could be defended using 12 batteries of interceptors with a range of 350 miles. It appears the most questionable aspect of the system is the interceptor missile. There are several interceptors under development, but none have been fully operationally tested. The ERIS interceptor under development by the Army may have the capabilities to be used in the system. Further research could prove the system to be a valuable asset.

  7. Vaporization of synthetic fuels. Final report. [Thesis

    SciTech Connect

    Sirignano, W.A.; Yao, S.C.; Tong, A.Y.; Talley, D.

    1983-01-01

    The problem of transient droplet vaporization in a hot convective environment is examined. The main objective of the present study is to develop an algorithm for the droplet vaporization which is simple enough to be feasibly incorporated into a complete spray combustion analysis and yet will also account for the important physics such as liquid-phase internal circulation, unsteady droplet heating and axisymmetric gas-phase convection. A simplified liquid-phase model has been obtained based on the assumption of the existence of a Hill's spherical vortex inside the droplet together with some approximations made in the governing diffusion equation. The use of the simplified model in a spray situation has also been examined. It has been found that droplet heating and vaporization are essentially unsteady and droplet temperature is nonuniform for a significant portion of its lifetime. It has also been found that the droplet vaporization characteristic can be quite sensitive to the particular liquid-phase and gas-phase models. The results of the various models are compared with the existing experimental data. Due to large scattering in the experimental measurements, particularly the droplet diameter, no definite conclusion can be drawn based on the experimental data. Finally, certain research problems which are related to the present study are suggested for future studies.

  8. The Space Station - A new frontier thesis

    NASA Astrophysics Data System (ADS)

    Rhea, J.

    1985-04-01

    Several firm equipment, configuration and applications concepts have emerged from preliminary design studies for the Space Station (SS), although budgetary considerations have already caused the projected launch to slip from 1993 to 1995. The baseline design requires strung-together compatible modules. The SS will serve commercial, basic sciences and military needs, provide a staging area for building structures larger than transportable whole by the STS, and will have power requirements that begin at 75 kWp. Compatibility with a 10 ft diam orbital maneuvering vehicle (OMV) is required, and crew will be rotated every 90-180 days. NASA will manage the project, a departure from prime contractor practices of past large programs. The initial SS will house four persons and is to be expandable to indeterminate dimensions. Photovoltaics are foreseen as the providers of initial power supplies.

  9. Diffuse flow from hydrothermal vents. Doctoral thesis

    SciTech Connect

    Trivett, D.A.

    1991-08-01

    The effluent from a collection of diffuse hydrothermal vents was modelled to determine the fate of the source of flow under typical environmental conditions at seafloor spreading centers. A laboratory simulation was conducted to test an analytic model of diffuse plume rise. The results showed that diffuse plumes are likely to remain near the seafloor, with their maximum rise height scaled with the diameter of the source of diffuse flow. The entrainment of ambient seawater into these plumes is limited by the proximity to the seafloor, thus slowing the rate of dilution. The model of diffuse plume behaviour was used to guide the design and implementation of a scheme for monitoring the flow from diffuse hydrothermal vents in the ocean. A deployment of an array at the Southern Juan de Fuca Ridge yielded measurements of a variety of diffuse plume properties, including total heat output. Two distinct sources of hydrothermal flow were detected during the field deployment. The larger source was 1-1.5km north of the instrument array, and its energy output was 450 + or - 270MW. A smaller source was located 100m east of one instrument in the array. The energy output of the source was 12 + or - 8MW. The rise heights of the centerlines of these plumes were 45m and 10m, respectively.

  10. Optically pumped molecular bromine laser. Master's thesis

    SciTech Connect

    Morrison, J.W.

    1990-12-01

    An optically pumped molecular bromine laser was studied to investigate the quenching kinetics state of Br2. This included characterization of the pressure dependence of the laser output power. The approach was to excite molecular bromine in a sealed cell with a Nd:YAG pumped dye laser. Unresolved side fluorescence and amplified stimulated emission (ASE) spectra were recorded. ASE offered the advantage of a simpler optical system with no externally induced wavelength dependencies. Stimulated emission as a signal monitor offered greater resolution than side fluorescence spectra and facilitated spectroscopic assignment. (JS)

  11. [Istanbul University Cerrahpaşa School of Medicine Department of Obstetrics and Gynecology: the list of diplomas and the related thesis of graduates in the twentieth century (1892-2000)].

    PubMed

    Kazancigil, A; Aksu, F

    2001-01-01

    Obstetrics Gynecology Department of Cerrahpaşa Faculty of Medicine is the first and the unique clinic which has ever been founded in Ottoman Empire by Besim Omer Pasha (Akalin) in 1892 under the name of "Veladethane" (meaning labor-in hospital) upon a decree of the Emperor. In 1909, it has been transferred from its first building located in Demirkapi Sirkeci to Kadirga and following a change from Kadiga to Haydaraşa in 1928. In 1933, after the university reform, it has moved again from Haydarpaşa. In 1966, from Haseki to Cerrahpaşa to its last and actual residence. Covering all these years, ten residents from Sirkeci, 17 from Kadirga, 7 from Haydaraşa, 195 from Haseki and 167 from Cerrahpaşa were graduated, all together they are 395 graduates. In this documentary you will find the list of their diplomas and thesis that have been officially accepted from 1946 to the presenting time. Essentially, many clinic, departments and specialty hospitals have been founded in Turkish Republic by these graduates and their successors of this faculty which has anniversarried its 108 years as an Obstetrics and Gynecology Department.

  12. "The Confessions of Nat Turner": Styron's "Meditation on History" as Rhetorical Act.

    ERIC Educational Resources Information Center

    Strine, Mary S.

    1978-01-01

    Examines Syron's novel as a strategic rhetorical response to the problems of racism in America with far-ranging implications in American social and institutional history. Argues that the novel's shaping vision illuminates the ethical dilemma of the liberal humanist and explores the ramifications of violence for self-definition and social reform.…

  13. Natürliche geogene Grundwasserbeschaffenheit in Baden-Württemberg

    NASA Astrophysics Data System (ADS)

    Plum, H.; Dietze, G.; Armbruster, V.; Wirsing, G.

    2009-12-01

    In order to investigate natural groundwater quality in Baden-Württemberg, 250 water samples from wells and springs of catchments with only little anthropogenic influence were chemically analysed. The study focused on the quantitative analysis of trace elements from natural sources. To assess the influence of atmospheric deposition on groundwater quality over a period of one year, monthly precipitation samples obtained from five meteorologic stations were also analysed. The groundwater hydrochemical data were obtained from 15 different hydrogeochemical units. The analytical data from the precipitation samples provide valuable information regarding the concentration of several elements in the atmospheric deposition in Baden-Württemberg. For near-surface groundwater with only limited anthropogenic influence, concentration ranges for more than 50 hydrochemical parameters are now available. The results provide a reliable database of the natural variation of trace elements. Potential anthropogenic influences can thus be evaluated by comparing future data against this natural background. For illustration, the results from the trace elements cobalt and uranium are presented in more detail.

  14. Umweltrelevanz von natürlichen polyzyklischen aromatischen Kohlenwasserstoffen aus Steinkohlen - eine Übersicht

    NASA Astrophysics Data System (ADS)

    Achten, C.; Hofmann, T.

    2010-03-01

    Releases of PAHs from hard (bituminous) coals into the environment have not been widely recognized. In hard coals, some hundreds of mg/kg of EPA-PAH and some thousands of mg/kg total PAH concentrations can occur and the concentrations vary significantly depending on hard coal maturity and origin. Highest PAH concentrations are present in the maturity range of the so-called “oil-window” (high volatile bituminous coal rank), however there is no general correlation. Only coals from the same origin can be compared. Naphthalene and phenanthrene as well as their alkylated derivatives are the dominant single polyaromatic compounds in hard coals. The PAH distribution patterns change with increasing rank from the low molecular weight, mostly alkylated compounds with linkage to the original organic material to the predominantly higher molecular weight parent compounds. The former are characteristic for coals of petrogenic origin and the latter for those of pyrogenic origin. Currently, PAHs from coals and from crude oil and its products cannot be distinguished by use of common simple diagnostic parameters. In countries holding large coal basins and associated mining activity, coal particles can comprise 10-15 % of the sediment or soil. Until today, little has been known about desorption and bioavailability of native PAH from coals. Literature studies so far show slow and very slow desorption and hardly any or no effects on organisms. This shows that there is a lack of systematic studies using heterogeneous coals from different countries. Bioavailability of PAH from coal particles in soils and sediments has an impact on risk assessment and should be included in sediment and soil standards.

  15. Nichtlineare Analyse von LC-TANK VCOs unter Berücksichtigung parasitärer Substrateffekte

    NASA Astrophysics Data System (ADS)

    Przytarski, J.; Bremer, J.-K.; Mathis, W.

    2009-05-01

    In dieser Arbeit wird ein Konzept vorgestellt, die Schaltungsarchitektur des LC-Tank-VCOs im höherdimensionalen Zustandsraum zu modellieren. Dabei wurde die VCO-Schaltung auf dominante nichtlineare und asymmetrische Effekte näher untersucht. Das entwickelte Modell bildet die Grundlage für nachfolgende parameterabhängige Analysen der Oszillatorschaltung mittels der Andronov-Hopf Bifurkationsanalyse. Zu diesem Zweck wurde ein höherdimensionales Modell entwickelt, welches für die Bifurkationsanalyse auf ein System 2. Ordnung reduziert werden muss. Als mathematisches Hilfsmittel zur Ordnungsreduktion des Systems wird das Verfahren der Zentrumsmannigfaltigkeit verwendet. Das Differentialgleichungssystem wird sehr schaltungsnah aufgestellt, daraus resultiert der Vorteil einer genaueren Repräsentation des physikalischen Verhaltens der Schaltung. Ziel ist es möglichst viele Effekte die sich auf das Verhalten des VCOs auswirken können, mit zu berücksichtigen.

  16. Ökophysik: Plaudereien über das Leben auf dem Land, im Wasser und in der Luft

    NASA Astrophysics Data System (ADS)

    Nachtigall, W.

    Prof. em. Dr. rer. nat. Werner Nachtigall, geb. 1934, war als Zoophysiologe und Biophysiker Leiter des Zoologischen Instituts der Universität des Saarlandes in Saarbrücken. In Forschung und Ausbildung hat er sich insbesondere mit Aspekten der Technischen Biologie und Bionik befasst und mit seinen Forschergruppen viele Basisdaten insbesondere zur Ökologie, Physiologie und Physik des Fliegens und Schwimmens aber auch zur Stabilität beispielsweise der Gräser erarbeitet. Lebewesen überraschen immer wieder durch ihre "Biodiversität", ihre hochspezifischen Ausgestaltungen und Anpassungen.

  17. Government Procurement. Crimes and Offenses (Thesis I of a Two-Thesis Project)

    DTIC Science & Technology

    1983-08-01

    might only receive an administrative reprimand for accepting an entertainment gratuity from an errant contractor, e.g., two tickets to a professional...rule. In Arthur, the court held that "goodwill" entertainment and gifts which were motivated by "some generalized hope or expectation of ultimate...officials with free gifts and entertainment to create a favorable business "climate" in order to secure Government deposits for a private commercial bank?1

  18. Synthesis and Mass Spectrometric Characterization of Organic Nitrates

    NASA Astrophysics Data System (ADS)

    Grünert, A.; Woidich, S.; Ballschmiter, K.

    2003-04-01

    Organic nitrates, as trace constituents in urban air, can be analyzed by adsorptive low volume sampling (LVS) as well as by adsorptive high volume sampling (HVS). Air samples ranging from 25 L to 100 L for the LVS and 100 m3 to 500 m3 for the (HVS) were collected, respectively. Analysis is performed by thermodesorption (LVS) or solvent elution combined with group separation (HVS) using normal-phase HPLC and high resolution capillary gas chromatography with electron capture detection (HRGC-ECD) and mass selective detection (HRGC-MSD). For identification and quantification available reference compounds are required for both methods (1;2). Following numbers of congeners of organic nitrate have been synthesized: 77 monoalkyl nitrates (C1-C16), 43 dialkyl nitrates (C2-C10), 37 hydroxy alkyl nitrates (C2-C8) and 41 carbonyl alkyl nitrates (C3-C12). Alkanes, alkenes, alcohols, ketones and halocarbons have been used as precursors. Characterisation of the reference compounds by retention-data and mass-spectra was performed by high resolution capillary gas chromatography with mass selective detection in the EI- and the NCI (CH4) mode (1-3). EI-ionization leads to the dominating indicator ion NO2+ for organic nitrates with m/z = 46 u. The characteristic fragments with NCI (CH4) show ions at m/z = 46 u and m/z = 62 u, corresponding to NO2- and NO3-. The use of flame ionisation detection (HRGC-FID) and the principle of the molar response for carbon allows the quantitation of reference solutions as the final tool for the determination of the levels and patterns of organic nitrates in urban air samples. (1) J. Kastler: "Analytik, Massenspektrometrie und Vorkommen multifunktioneller Alkylnitrate in belasteter und unbelasteter Atmosphäre" Dr.rer.nat.-Thesis, University of Ulm (1999) (2) G. Werner, J. Kastler, R. Looser, K. Ballschmiter: "Organic Nitrates of Isoprenes as Atmospheric Trace Compounds" Angew. Chem. Int. Ed. (1999) 38(11): 1634-1637 (3) S.Woidich, O. Froscheis, O

  19. High through-put aspirator and bioassay system for the evaluation of residual pesticides applied to nat. and artificial substrates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The advancement and testing of residual insecticides on insects is an ongoing mission because of continuous changes in insecticide tolerance. To assay residual insecticides efficiently and rapidly it is necessary for a bioassay to consists of streamlined procedures and equipment specifically intend...

  20. Investigation of excitation functions of alpha induced reactions on natXe: Production of the therapeutic radioisotope 131Cs

    NASA Astrophysics Data System (ADS)

    Tárkányi, F.; Hermanne, A.; Király, B.; Takács, S.; Ditrói, F.; Sonck, M.; Kovalev, S. F.; Ignatyuk, A. V.

    2009-03-01

    Excitation functions were measured for alpha-particle induced nuclear reactions on natural xenon leading to the formation of the radionuclides 129m(rel),129g,131m,131mg,133m,135m,137m,139cumBa and 129cum,130mg,132,134m,135m,136mg,138mgCs from the respective thresholds up to 40 MeV. No earlier experimental cross section data were found in the literature. The experimental data were compared to and analyzed with the results of the theoretical model code ALICE-IPPE. The feasibility of the production of the therapeutic radioisotope 131Cs by using gas target technology was investigated. Comparison of reactor and cyclotron production routes of 131Cs was given.

  1. Final Report for PV Incubator Subcontract No. NAT-7-77015-05: October 19, 2007 - July 30, 2009

    SciTech Connect

    Pan, N.

    2012-04-01

    The Solar America Initiative (SAI) is intended to provide numerous technological routes towards a lower levelized cost of solar-generated electricity (LCOE). MicroLink's planned contribution towards the SAI is to provide a method of lowering the cost of GaAs-based solar cells, which are a major contributor to the cost of concentrator photovoltaic (CPV) modules. MicroLink's unique approach is to use an epitaxial liftoff (ELO) process to completely remove the active solar cell from the substrate while preserving the performance and yield of the cell. The substrate accounts for approximately half the cost of conventional, multijunction GaAs-based solar cells. By using ELO, the substrate can be reused several times for additional solar cell growths, thereby reducing the cost of multijunction solar cells by up to 50%. The achievement of high efficiency has significantly increased the acceptance of MicroLink Devices as a future supplier of high-efficiency dual-junction and IMM (inverted metamorphic) triple-junction ELO solar cells. MicroLink entered the SAI program with a 10% efficiency GaAs solar cell (1-sun AM 1.5) and finished the program with an NREL-verified IMM triple-junction ELO solar cell (1-sun AM 1.5).

  2. Final Report for PV Incubator Subcontract No. NAT-0-99013-01: June 14, 2010 - March 2, 2012

    SciTech Connect

    Ghosal, K.

    2012-04-01

    The goal of the subcontract is to scale up Semprius' novel micro-cell based modules to an annualized rate of 500 kW of receivers and 10 kW of modules, in support of the DOE 2020 Sunshot Initiative goals. The statement of work (SOW) was broken up into two Phases. Phase I was directed towards process development efforts towards addressing fundamental manufacturing metrics such as yield, die per wafer, automation and throughput. Phase II objectives are to scale to an annualized production rate of 500 kW of receivers and 10 kW of modules, while improving cell efficiency, module efficiency and transfer yield. Semprius has met all the technical milestones and deliverables for the contract. All subtasks were completed earlier than expected and the results exceeded the technical targets. In particular, 3J cell efficiency of 41.2% exceeded the target of 38%, module efficiency of 28.3% exceeded the target of 28% and transfer yield of 96.4% exceeds the target of 95%, with all tasks completed well ahead of schedule. Also, devices fabricated from 1st use GaAs substrates and substrates with two re-uses have been shown to be identical.

  3. 14 CFR Appendix C to Part 91 - Operations in the North Atlantic (NAT) Minimum Navigation Performance Specifications (MNPS) Airspace

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Pt. 91, App. C Appendix C to Part 91—Operations in the... shall be less than 6.3 NM (11.7 Km). Standard deviation is a statistical measure of data about a...

  4. Optimization of Clonazepam Therapy Adjusted to Patient’s CYP3A Status and NAT2 Genotype

    PubMed Central

    Tóth, Katalin; Csukly, Gábor; Sirok, Dávid; Belic, Ales; Kiss, Ádám; Háfra, Edit; Déri, Máté; Menus, Ádám; Bitter, István

    2016-01-01

    Background: The shortcomings of clonazepam therapy include tolerance, withdrawal symptoms, and adverse effects such as drowsiness, dizziness, and confusion leading to increased risk of falls. Inter-individual variability in the incidence of adverse events in patients partly originates from the differences in clonazepam metabolism due to genetic and nongenetic factors. Methods: Since the prominent role in clonazepam nitro-reduction and acetylation of 7-amino-clonazepam is assigned to CYP3A and N-acetyl transferase 2 enzymes, respectively, the association between the patients’ CYP3A status (CYP3A5 genotype, CYP3A4 expression) or N-acetyl transferase 2 acetylator phenotype and clonazepam metabolism (plasma concentrations of clonazepam and 7-amino-clonazepam) was evaluated in 98 psychiatric patients suffering from schizophrenia or bipolar disorders. Results: The patients’ CYP3A4 expression was found to be the major determinant of clonazepam plasma concentrations normalized by the dose and bodyweight (1263.5±482.9 and 558.5±202.4ng/mL per mg/kg bodyweight in low and normal expressers, respectively, P<.0001). Consequently, the dose requirement for the therapeutic concentration of clonazepam was substantially lower in low-CYP3A4 expresser patients than in normal expressers (0.029±0.011 vs 0.058±0.024mg/kg bodyweight, P<.0001). Furthermore, significantly higher (about 2-fold) plasma concentration ratio of 7-amino-clonazepam and clonazepam was observed in the patients displaying normal CYP3A4 expression and slower N-acetylation than all the others. Conclusion: Prospective assaying of CYP3A4 expression and N-acetyl transferase 2 acetylator phenotype can better identify the patients with higher risk of adverse reactions and can facilitate the improvement of personalized clonazepam therapy and withdrawal regimen. PMID:27639091

  5. Extension of the excitation functions of deuteron induced reactions on natSn up to 50 MeV

    NASA Astrophysics Data System (ADS)

    Hermanne, A.; Tárkányi, F.; Ditrói, F.; Takács, S.

    2017-01-01

    Using the stacked-foil activation technique, cross-sections of deuteron induced reactions on natural Sn targets were determined up to 50 MeV. Excitation functions are reported for the product nuclides 116mSb, 117Sb, 118mSb, 120mSb 122m+gSb, 124m+gSb, 110Sn(cum), 113m+gSn(cum), 117mSn, 110mIn(cum), 110gIn, 111m+gIn(cum), 113mIn, 114mIn 115mIn. Comparison with earlier published data at lower energy is discussed. For all excitation functions a theoretical calculation using the TALYS 1.6 (on-line TENDL-2015 library) code is shown.

  6. Lipopeptide als natürliche Adjuvantien für Impfstoffe aus Gram-negativen Bakterien

    NASA Astrophysics Data System (ADS)

    Schlecht, S.; Wiesmüller, K.-H.; Jung, G.; Bessler, W. G.

    1993-01-01

    Bacterial cell wall components such as lipopolysaccharide, a variety of membrane proteins, murein, and lipoprotein can act as immunoadjuvants for bacterial vaccines, thus enhancing protection from bacterial infections. Synthetically prepared N-terminal parts of the lipoprotein from Enterobacteria carrying three fatty acid residues or lipopeptide analogs containing one to four aminoacids bound to S-glycerylcysteine act as potent immunoadjuvants in vivo in combination with or covalently linked to antiges. Here we demonstrate that the supplementation of Salmonella vaccines with these synthetic lipopeptides significantly enhances their vaccine efficiency in mice. Variations in the native lipopeptide structure regarding chain length and amino acid sequence of the peptide moiety, as well as modifications of the lipoamino acid, lead to reduction or even complete loss of the adjuvant activity. The immunoadjuvant properties of the lipopeptides as described here are mediated by an enhancement of the humoral immune response.

  7. Simplified preliminary economic analysis for passive solar heating. Master's thesis

    SciTech Connect

    Baldetti, P.J.; Lockard, M.A.

    1983-09-01

    This report establishes economic feasibility criteria for considering the use of passive solar design. In light of the growing cost of supplying the energy demands of the Air Force, a method is needed to simplify the adaptation of passive solar heating and cooling in future building construction.

  8. Asbestos removal in the construction industry. Master's thesis

    SciTech Connect

    Banks, A.J.

    1991-01-01

    The purpose of this report is to examine the impact of asbestos abatement on the construction industry. It is estimated that the cleanup effort may cost $100 billion over the next twenty five years. More than 733,000 structures, or twenty percent of U. S. commercial and public properties are believed to contain asbestos. Some of the material is in a friable state. This asbestos is crumbling into microscopic fibers that can float in through the air. The use of asbestos was restricted after high doses of its fibers were found to scar lungs, causing cancer and other diseases. Construction businesses use 50 percent of the U. S. supply of asbestos in asbestos cement pipes, sheets, siding shingles, floor tiles, coatings, and sealants. Some 29,000 workers install asbestos insulation during building construction. Other estimates of exposed workers include 20,400 in demolition, 67,800 in abatement, 82,500 in general building renovation, 135,700 doing routine maintenance in buildings, and 183,200 in routine maintenance in general industry. The demand for asbestos removal services exceeds the ability of the industry to supply it safely. Asbestos management and removal are major issues for the construction industry world wide.

  9. Analysis of a Multiprocessor Guidance Computer. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Maltach, E. G.

    1969-01-01

    The design of the next generation of spaceborne digital computers is described. It analyzes a possible multiprocessor computer configuration. For the analysis, a set of representative space computing tasks was abstracted from the Lunar Module Guidance Computer programs as executed during the lunar landing, from the Apollo program. This computer performs at this time about 24 concurrent functions, with iteration rates from 10 times per second to once every two seconds. These jobs were tabulated in a machine-independent form, and statistics of the overall job set were obtained. It was concluded, based on a comparison of simulation and Markov results, that the Markov process analysis is accurate in predicting overall trends and in configuration comparisons, but does not provide useful detailed information in specific situations. Using both types of analysis, it was determined that the job scheduling function is a critical one for efficiency of the multiprocessor. It is recommended that research into the area of automatic job scheduling be performed.

  10. The fin de siècle thesis.

    PubMed

    Staley, Richard

    2008-12-01

    This paper examines the relations between John Heilbron's argument that fin de siècle physicists adjusted the image and substance of their discipline to cultural concerns, and Paul Forman's approach to acau-sality in the Weimar period. In addition to their focus on representation rather than truth, adherents of the "descriptionist" epistemologies that Heilbron identified also promoted an emphasis on method, statistical rather than causal explanations, historical understandings of epistemology, and stressed the relations between physics and other disciplines. Their views provide an intellectual context--within the physics discipline--for at least some part of what Forman had described as a capitulation to the hostile social environment expressed in Oswald Spengler's Der Untergang des Abendlandes.

  11. Verge of Collapse: The Pros/thesis of Art Research

    ERIC Educational Resources Information Center

    Garoian, Charles R.

    2008-01-01

    This article explores "prosthesis" as a metaphor of embodiment in art-based research to challenge the utopian myth of wholeness and normality in art and the human body. Bearing in mind the correspondences between amputated bodies and the cultural dislocations of art, I propose "prosthetic epistemology" and "prosthetic ontology" as embodied knowing…

  12. Nonlinear analysis of laminated fibrous composites. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Renieri, G. D.; Herakovich, C. T.

    1976-01-01

    A computerized analysis of the nonlinear behavior of fibrous composite laminates including axial loading, thermal loading, temperature dependent properties, and edge effects is presented. Ramberg-Osgood approximations are used to represent lamina stress-strain behavior and percent retention curves are employed to model the variation of properties with temperature. Balanced, symmetric laminates comprised of either boron/epoxy, graphite/epoxy, or borsic-aluminum are analyzed using a quasi-three-dimensional finite element analysis. Results are presented for the interlaminar stress distributions in cross-ply, angle-ply, and more complex laminates. Nonlinear stress-strain curves for a variety of composite laminates in tension and compression are obtained and compared to other existing theories and experimental results.

  13. Implications of the ’Nuclear Winter’ Thesis.

    DTIC Science & Technology

    1985-06-24

    Social Responsibility activities, see their Spring 1984 PSR Newsletter, especially "The Risks of Nuclear War: New Data, New Technology." 18. The Center...Committee Hearings (July 11-12, 1984); and Physicians for Social Responsibility which conducted 56 panels entitled, "Nuclear War and Survival" that have...Omaha ". World-Herald, July 24, 1984. 64. Physicians for Social Responsibility , "The Risks of Nuclear War; New Data, New Technology," PSR Newsletter

  14. Investigation of the Vortex Tab. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Hoffler, K. D.

    1985-01-01

    An investigation was made into the drag reduction capability of vortex tabs on delta wing vortex flaps. The vortex tab is an up-deflected leading edge portion of the vortex flap. Tab deflection augments vortex suction on the flap, thus improving its thrust, but the tab itself is drag producing. Whether a net improvement in the drag reduction can be obtained with vortex tabs, in comparison with plane vortex flaps of the same total area, was the objective of this investigation. Wind tunnel tests were conducted on two models, and analytical studies were performed on one of them using a free vortex sheet theory.

  15. Video transmission on ATM networks. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Chen, Yun-Chung

    1993-01-01

    The broadband integrated services digital network (B-ISDN) is expected to provide high-speed and flexible multimedia applications. Multimedia includes data, graphics, image, voice, and video. Asynchronous transfer mode (ATM) is the adopted transport techniques for B-ISDN and has the potential for providing a more efficient and integrated environment for multimedia. It is believed that most broadband applications will make heavy use of visual information. The prospect of wide spread use of image and video communication has led to interest in coding algorithms for reducing bandwidth requirements and improving image quality. The major results of a study on the bridging of network transmission performance and video coding are: Using two representative video sequences, several video source models are developed. The fitness of these models are validated through the use of statistical tests and network queuing performance. A dual leaky bucket algorithm is proposed as an effective network policing function. The concept of the dual leaky bucket algorithm can be applied to a prioritized coding approach to achieve transmission efficiency. A mapping of the performance/control parameters at the network level into equivalent parameters at the video coding level is developed. Based on that, a complete set of principles for the design of video codecs for network transmission is proposed.

  16. Heat Pipe Vapor Dynamics. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Issacci, Farrokh

    1990-01-01

    The dynamic behavior of the vapor flow in heat pipes is investigated at startup and during operational transients. The vapor is modeled as two-dimensional, compressible viscous flow in an enclosure with inflow and outflow boundary conditions. For steady-state and operating transients, the SIMPLER method is used. In this method a control volume approach is employed on a staggered grid which makes the scheme very stable. It is shown that for relatively low input heat fluxes the compressibility of the vapor flow is low and the SIMPLER scheme is suitable for the study of transient vapor dynamics. When the input heat flux is high or the process under a startup operation starts at very low pressures and temperatures, the vapor is highly compressible and a shock wave is created in the evaporator. It is shown that for a wide range of input heat fluxes, the standard methods, including the SIMPLER scheme, are not suitable. A nonlinear filtering technique, along with the centered difference scheme, are then used for shock capturing as well as for the solution of the cell Reynolds-number problem. For high heat flux, the startup transient phase involves multiple shock reflections in the evaporator region. Each shock reflection causes a significant increase in the local pressure and a large pressure drop along the heat pipe. Furthermore, shock reflections cause flow reversal in the evaporation region and flow circulations in the adiabatic region. The maximum and maximum-averaged pressure drops in different sections of the heat pipe oscillate periodically with time because of multiple shock reflections. The pressure drop converges to a constant value at steady state. However, it is significantly higher than its steady-state value at the initiation of the startup transient. The time for the vapor core to reach steady-state condition depends on the input heat flux, the heat pipe geometry, the working fluid, and the condenser conditions. However, the vapor transient time, for an Na-filled heat pipe is on the order of seconds. Depending on the time constant for the overall system, the vapor transient time may be very short. Therefore, the vapor core may be assumed to be quasi-steady in the transient analysis of a heat pipe operation.

  17. The Decompensated Monofixation Syndrome (An American Ophthalmological Society Thesis)

    PubMed Central

    Siatkowski, R. Michael

    2011-01-01

    Purpose To describe the clinical features and response to treatment of patients with decompensated monofixation syndrome (MFS) and to propose a hypothesis for a decompensation mechanism in such patients. Methods Fourteen adults with MFS who had been symptomatically stable for a mean duration of 25 years developed diplopia in the absence of neurologic or orbital disease. After retrospective chart review, they underwent detailed orthoptic testing. Results from this cross-sectional analysis were compared with similar data from 16 control subjects with stable MFS. Results Compared to stable MFS patients, decompensated subjects had significantly poorer horizontal fusional amplitudes but greater torsional fusional amplitudes; they were also more likely to have a small vertical strabismus and to have received initial treatment later. Stable subjects, however, also had subnormal horizontal as well as torsional fusional amplitudes. There was no difference between groups with respect to refractive error, amblyopia, type or prior treatment of strabismus, stereoacuity, or angle of deviation. After treatment, all patients regained monofixational alignment, but up to one-third had continued diplopia. Symptoms recurred in two patients whose treatment was initially successful. Conclusions Patients with MFS lose fusional amplitudes over time. In some cases this results in development of sensory torsion with secondary decompensation and diplopia. The rate of decompensation averages 7% per year from ages 20 to 70. Treatment for decompensation offers excellent motor results, but sensory symptoms may persist and recurrent symptoms may develop. Monitoring and maintenance of fusional vergence amplitudes should be part of the routine care for patients with MFS. PMID:22253490

  18. Reliable fusion of control and sensing in intelligent machines. Thesis

    NASA Technical Reports Server (NTRS)

    Mcinroy, John E.

    1991-01-01

    Although robotics research has produced a wealth of sophisticated control and sensing algorithms, very little research has been aimed at reliably combining these control and sensing strategies so that a specific task can be executed. To improve the reliability of robotic systems, analytic techniques are developed for calculating the probability that a particular combination of control and sensing algorithms will satisfy the required specifications. The probability can then be used to assess the reliability of the design. An entropy formulation is first used to quickly eliminate designs not capable of meeting the specifications. Next, a framework for analyzing reliability based on the first order second moment methods of structural engineering is proposed. To ensure performance over an interval of time, lower bounds on the reliability of meeting a set of quadratic specifications with a Gaussian discrete time invariant control system are derived. A case study analyzing visual positioning in robotic system is considered. The reliability of meeting timing and positioning specifications in the presence of camera pixel truncation, forward and inverse kinematic errors, and Gaussian joint measurement noise is determined. This information is used to select a visual sensing strategy, a kinematic algorithm, and a discrete compensator capable of accomplishing the desired task. Simulation results using PUMA 560 kinematic and dynamic characteristics are presented.

  19. Characterization of measurements in quantum communication. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Chan, V. W. S.

    1975-01-01

    A characterization of quantum measurements by operator valued measures is presented. The generalized measurements include simultaneous approximate measurement of noncommuting observables. This characterization is suitable for solving problems in quantum communication. Two realizations of such measurements are discussed. The first is by adjoining an apparatus to the system under observation and performing a measurement corresponding to a self-adjoint operator in the tensor-product Hilbert space of the system and apparatus spaces. The second realization is by performing, on the system alone, sequential measurements that correspond to self-adjoint operators, basing the choice of each measurement on the outcomes of previous measurements. Simultaneous generalized measurements are found to be equivalent to a single finer grain generalized measurement, and hence it is sufficient to consider the set of single measurements. An alternative characterization of generalized measurement is proposed. It is shown to be equivalent to the characterization by operator-values measures, but it is potentially more suitable for the treatment of estimation problems. Finally, a study of the interaction between the information-carrying system and a measurement apparatus provides clues for the physical realizations of abstractly characterized quantum measurements.

  20. Triangular covariance factorizations for. Ph.D. Thesis. - Calif. Univ.

    NASA Technical Reports Server (NTRS)

    Thornton, C. L.

    1976-01-01

    An improved computational form of the discrete Kalman filter is derived using an upper triangular factorization of the error covariance matrix. The covariance P is factored such that P = UDUT where U is unit upper triangular and D is diagonal. Recursions are developed for propagating the U-D covariance factors together with the corresponding state estimate. The resulting algorithm, referred to as the U-D filter, combines the superior numerical precision of square root filtering techniques with an efficiency comparable to that of Kalman's original formula. Moreover, this method is easily implemented and involves no more computer storage than the Kalman algorithm. These characteristics make the U-D method an attractive realtime filtering technique. A new covariance error analysis technique is obtained from an extension of the U-D filter equations. This evaluation method is flexible and efficient and may provide significantly improved numerical results. Cost comparisons show that for a large class of problems the U-D evaluation algorithm is noticeably less expensive than conventional error analysis methods.

  1. Takeoff predictions for powered-lift aircraft. Thesis

    NASA Technical Reports Server (NTRS)

    Wardwell, Douglas A.; Sandlin, Doral R.

    1988-01-01

    Takeoff predictions for powered-lift short takeoff (STO) and conventional takeoff (CTO) aircraft have been added to NASA Ames Research Center's Aircraft Synthesis (ACSYNT) code. The new computer code predicts the aircraft engine and nozzle settings required to achieve the minimum takeoff roll. As a test case, the code predicted takeoff ground rolls and nozzle settings for the YAV-8B Harrier that compared well with measured values. Brief analysis of takeoff performance for an Ejector, Remote Augmented Lift, Hybrid-Tandem Fan, and Vectored Thrust STO aircraft using the new routine will be presented.

  2. The Jade File System. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Rao, Herman Chung-Hwa

    1991-01-01

    File systems have long been the most important and most widely used form of shared permanent storage. File systems in traditional time-sharing systems, such as Unix, support a coherent sharing model for multiple users. Distributed file systems implement this sharing model in local area networks. However, most distributed file systems fail to scale from local area networks to an internet. Four characteristics of scalability were recognized: size, wide area, autonomy, and heterogeneity. Owing to size and wide area, techniques such as broadcasting, central control, and central resources, which are widely adopted by local area network file systems, are not adequate for an internet file system. An internet file system must also support the notion of autonomy because an internet is made up by a collection of independent organizations. Finally, heterogeneity is the nature of an internet file system, not only because of its size, but also because of the autonomy of the organizations in an internet. The Jade File System, which provides a uniform way to name and access files in the internet environment, is presented. Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Because of autonomy, Jade is designed under the restriction that the underlying file systems may not be modified. In order to avoid the complexity of maintaining an internet-wide, global name space, Jade permits each user to define a private name space. In Jade's design, we pay careful attention to avoiding unnecessary network messages between clients and file servers in order to achieve acceptable performance. Jade's name space supports two novel features: (1) it allows multiple file systems to be mounted under one direction; and (2) it permits one logical name space to mount other logical name spaces. A prototype of Jade was implemented to examine and validate its design. The prototype consists of interfaces to the Unix File System, the Sun Network File System, and the File Transfer Protocol.

  3. Multipole gas thruster design. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Isaacson, G. C.

    1977-01-01

    The development of a low field strength multipole thruster operating on both argon and xenon is described. Experimental results were obtained with a 15-cm diameter multipole thruster and are presented for a wide range of discharge-chamber configurations. Minimum discharge losses were 300-350 eV/ion for argon and 200-250 eV/ion for xenon. Ion beam flatness parameters in the plane of the accelerator grid ranged from 0.85 to 0.93 for both propellants. Thruster performance is correlated for a range of ion chamber sizes and operating conditions as well as propellant type and accelerator system open area. A 30-cm diameter ion source designed and built using the procedure and theory presented here-in is shown capable of low discharge losses and flat ion-beam profiles without optimization. This indicates that by using the low field strength multipole design, as well as general performance correlation information provided herein, it should be possible to rapidly translate initial performance specifications into easily fabricated, high performance prototypes.

  4. Robust crossfeed design for hovering rotorcraft. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Catapang, David R.

    1993-01-01

    Control law design for rotorcraft fly-by-wire systems normally attempts to decouple angular responses using fixed-gain crossfeeds. This approach can lead to poor decoupling over the frequency range of pilot inputs and increase the load on the feedback loops. In order to improve the decoupling performance, dynamic crossfeeds may be adopted. Moreover, because of the large changes that occur in rotorcraft dynamics due to small changes about the nominal design condition, especially for near-hovering flight, the crossfeed design must be 'robust.' A new low-order matching method is presented here to design robost crossfeed compensators for multi-input, multi-output (MIMO) systems. The technique identifies degrees-of-freedom that can be decoupled using crossfeeds, given an anticipated set of parameter variations for the range of flight conditions of concern. Cross-coupling is then reduced for degrees-of-freedom that can use crossfeed compensation by minimizing off-axis response magnitude average and variance. Results are presented for the analysis of pitch, roll, yaw, and heave coupling of the UH-60 Black Hawk helicopter in near-hovering flight. Robust crossfeeds are designed that show significant improvement in decoupling performance and robustness over nominal, single design point, compensators. The design method and results are presented in an easily-used graphical format that lends significant physical insight to the design procedure. This plant pre-compensation technique is an appropriate preliminary step to the design of robust feedback control laws for rotorcraft.

  5. Communication theory of quantum systems. Ph.D. Thesis, 1970

    NASA Technical Reports Server (NTRS)

    Yuen, H. P. H.

    1971-01-01

    Communication theory problems incorporating quantum effects for optical-frequency applications are discussed. Under suitable conditions, a unique quantum channel model corresponding to a given classical space-time varying linear random channel is established. A procedure is described by which a proper density-operator representation applicable to any receiver configuration can be constructed directly from the channel output field. Some examples illustrating the application of our methods to the development of optical quantum channel representations are given. Optimizations of communication system performance under different criteria are considered. In particular, certain necessary and sufficient conditions on the optimal detector in M-ary quantum signal detection are derived. Some examples are presented. Parameter estimation and channel capacity are discussed briefly.

  6. Focusing on Doctoral Students' Experiences of Engagement in Thesis Work

    ERIC Educational Resources Information Center

    Vekkaila, Jenna; Pyhältö, Kirsi; Lonka, Kirsti

    2013-01-01

    Little is known about what inspires students to be involved in their doctoral process and stay persistent when facing challenges. This study explored the nature of students' engagement in the doctoral work. Altogether, 21 behavioural sciences doctoral students from one top-level research community were interviewed. The interview data were…

  7. Design, Implementation, and Verification of the Reliable Multicast Protocol. Thesis

    NASA Technical Reports Server (NTRS)

    Montgomery, Todd L.

    1995-01-01

    This document describes the Reliable Multicast Protocol (RMP) design, first implementation, and formal verification. RMP provides a totally ordered, reliable, atomic multicast service on top of an unreliable multicast datagram service. RMP is fully and symmetrically distributed so that no site bears an undue portion of the communications load. RMP provides a wide range of guarantees, from unreliable delivery to totally ordered delivery, to K-resilient, majority resilient, and totally resilient atomic delivery. These guarantees are selectable on a per message basis. RMP provides many communication options, including virtual synchrony, a publisher/subscriber model of message delivery, a client/server model of delivery, mutually exclusive handlers for messages, and mutually exclusive locks. It has been commonly believed that total ordering of messages can only be achieved at great performance expense. RMP discounts this. The first implementation of RMP has been shown to provide high throughput performance on Local Area Networks (LAN). For two or more destinations a single LAN, RMP provides higher throughput than any other protocol that does not use multicast or broadcast technology. The design, implementation, and verification activities of RMP have occurred concurrently. This has allowed the verification to maintain a high fidelity between design model, implementation model, and the verification model. The restrictions of implementation have influenced the design earlier than in normal sequential approaches. The protocol as a whole has matured smoother by the inclusion of several different perspectives into the product development.

  8. Robust failure detection filters. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Sanmartin, A. M.

    1985-01-01

    The robustness of detection filters applied to the detection of actuator failures on a free-free beam is analyzed. This analysis is based on computer simulation tests of the detection filters in the presence of different types of model mismatch, and on frequency response functions of the transfers corresponding to the model mismatch. The robustness of detection filters based on a model of the beam containing a large number of structural modes varied dramatically with the placement of some of the filter poles. The dynamics of these filters were very hard to analyze. The design of detection filters with a number of modes equal to the number of sensors was trivial. They can be configured to detect any number of actuator failure events. The dynamics of these filters were very easy to analyze and their robustness properties were much improved. A change of the output transformation allowed the filter to perform satisfactorily with realistic levels of model mismatch.

  9. Elemental composition of solar energetic particles. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Cook, W. R., III

    1981-01-01

    The Low Energy Telescopes on the Voyager spacecraft are used to measure the elemental composition (2 or = Z or = 28) and energy spectra (5 to 15 MeV/nucleon) of solar energetic particles (SEPs) in seven large flare events. Four flare events are selected which have SEP abundance ratios approximately independent of energy/nucleon. The abundances for these events are compared from flare to flare and are compared to solar abundances from other sources: spectroscopy of the photosphere and corona, and solar wind measurements. The four flare average SEP composition is significantly different from the solar composition determined by photospheric spectroscopy. The average SEP composition is in agreement with solar wind abundance results and with a number of recent coronal abundance measurements. The evidence for a common depletion of oxygen in SEPs, the corona and the solar wind relative to the photosphere suggest that the SEPs originate in the corona and that both the SEPs and solar wind sample a coronal composition which is significantly and persistently different from that of the photosphere.

  10. Injection efficiency of bound modes. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Egalon, Claudio Oliveira

    1990-01-01

    Previous work on efficiency of light injection into the core of a fiber from a thin film and a bulk distribution of sources in the cladding have used the fields of a weakly guiding fiber. This approximation simplifies the analysis of the power efficiency by introducing universal values for the eigenvalues of different fibers with the same V-number, but cannot predict accurately the behavior of the injected light into a fiber with arbitrary differences in indices of refraction. The exact field solution was used in the expressions of the power efficiency, p sub eff, and its behavior as a function of the fiber parameter was analyzed. Weakly guiding results obtained previously are confirmed. However, P sub eff does not always increase with the V-number but with the difference in the indices of refraction, eta sub core-eta sub clad. For the bulk distribution it was found that P sub eff increases with the wavelength, lambda, and decreases with the fiber core radius, a, i.e., it decreases with the V-number. However, for the thin film, the P sub eff remains almost constant with lambda and the fiber core radius.

  11. Managing Organization Vitality. M.S. Thesis - MIT, Cambridge

    NASA Technical Reports Server (NTRS)

    Chandler, G. P., Jr.

    1976-01-01

    The three major objectives are: (1) to measure the extent to which the organization renewal techniques have been adopted by organizations in both the private and public sectors; (2) to determine the overall results of these applications; and (3) to test a number of specific hypotheses regarding situational determinants of the success of this approach. It appears that top management involvement is the single most crucial determinant of the success of organization renewal. Organization renewal has considerable potential for increasing the commitment of individuals, and can have a significant positive influence on the results of the organization.

  12. Design of an interactive accounting tutor. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Macko, J.

    1970-01-01

    A project to design an interactive program to teach accounting techniques is described. The four major goals of the project are discussed and a review of the literature on teaching machines and computer-assisted-instruction is included. The system is implemented on the CTSS time sharing system at M.I.T. and uses an ARDS graphic display. The software design of the system is described in detail. A typical session with the tutor is also described. Appendices include complete system documentation.

  13. Software Coherence in Multiprocessor Memory Systems. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Bolosky, William Joseph

    1993-01-01

    Processors are becoming faster and multiprocessor memory interconnection systems are not keeping up. Therefore, it is necessary to have threads and the memory they access as near one another as possible. Typically, this involves putting memory or caches with the processors, which gives rise to the problem of coherence: if one processor writes an address, any other processor reading that address must see the new value. This coherence can be maintained by the hardware or with software intervention. Systems of both types have been built in the past; the hardware-based systems tended to outperform the software ones. However, the ratio of processor to interconnect speed is now so high that the extra overhead of the software systems may no longer be significant. This issue is explored both by implementing a software maintained system and by introducing and using the technique of offline optimal analysis of memory reference traces. It finds that in properly built systems, software maintained coherence can perform comparably to or even better than hardware maintained coherence. The architectural features necessary for efficient software coherence to be profitable include a small page size, a fast trap mechanism, and the ability to execute instructions while remote memory references are outstanding.

  14. Confined Turbulent Swirling Recirculating Flow Predictions. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Abujelala, M. T.

    1984-01-01

    Turbulent swirling flow, the STARPIC computer code, turbulence modeling of turbulent flows, the k-xi turbulence model and extensions, turbulence parameters deduction from swirling confined flow measurements, extension of the k-xi to confined swirling recirculating flows, and general predictions for confined turbulent swirling flow are discussed.

  15. Randomly Sampled-Data Control Systems. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Han, Kuoruey

    1990-01-01

    The purpose is to solve the Linear Quadratic Regulator (LQR) problem with random time sampling. Such a sampling scheme may arise from imperfect instrumentation as in the case of sampling jitter. It can also model the stochastic information exchange among decentralized controllers to name just a few. A practical suboptimal controller is proposed with the nice property of mean square stability. The proposed controller is suboptimal in the sense that the control structure is limited to be linear. Because of i. i. d. assumption, this does not seem unreasonable. Once the control structure is fixed, the stochastic discrete optimal control problem is transformed into an equivalent deterministic optimal control problem with dynamics described by the matrix difference equation. The N-horizon control problem is solved using the Lagrange's multiplier method. The infinite horizon control problem is formulated as a classical minimization problem. Assuming existence of solution to the minimization problem, the total system is shown to be mean square stable under certain observability conditions. Computer simulations are performed to illustrate these conditions.

  16. Acceleration techniques for dependability simulation. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Barnette, James David

    1995-01-01

    As computer systems increase in complexity, the need to project system performance from the earliest design and development stages increases. We have to employ simulation for detailed dependability studies of large systems. However, as the complexity of the simulation model increases, the time required to obtain statistically significant results also increases. This paper discusses an approach that is application independent and can be readily applied to any process-based simulation model. Topics include background on classical discrete event simulation and techniques for random variate generation and statistics gathering to support simulation.

  17. Pulse analysis of acoustic emission signals. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Houghton, J. R.

    1976-01-01

    A method for the signature analysis of pulses in the frequency domain and the time domain is presented. Fourier spectrum, Fourier transfer function, shock spectrum and shock spectrum ratio are examined in the frequency domain analysis, and pulse shape deconvolution is developed for use in the time domain analysis. To demonstrate the relative sensitivity of each of the methods to small changes in the pulse shape, signatures of computer modeled systems with analytical pulses are presented. Optimization techniques are developed and used to indicate the best design parameters values for deconvolution of the pulse shape. Several experiments are presented that test the pulse signature analysis methods on different acoustic emission sources. These include acoustic emissions associated with: (1) crack propagation, (2) ball dropping on a plate, (3) spark discharge and (4) defective and good ball bearings.

  18. Marie Curie's Doctoral Thesis: Prelude to a Nobel Prize.

    ERIC Educational Resources Information Center

    Wolke, Robert L.

    1988-01-01

    Traces the life and research techniques of Marie Curie's doctoral dissertation leading to the discovery and purification of radium from ore. Reexamines the discoveries of other scientists that helped lead to this separation. (ML)

  19. ICE System: Interruptible control expert system. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Vezina, James M.

    1990-01-01

    The Interruptible Control Expert (ICE) System is based on an architecture designed to provide a strong foundation for real-time production rule expert systems. Three principles are adopted to guide the development of ICE. A practical delivery platform must be provided, no specialized hardware can be used to solve deficiencies in the software design. Knowledge of the environment and the rule-base is exploited to improve the performance of a delivered system. The third principle of ICE is to respond to the most critical event, at the expense of the more trivial tasks. Minimal time is spent on classifying the potential importance of environmental events with the majority of the time used for finding the responses. A feature of the system, derived from all three principles, is the lack of working memory. By using a priori information, a fixed amount of memory can be specified for the hardware platform. The absence of working memory removes the dangers of garbage collection during the continuous operation of the controller.

  20. Behavioral model simulation studies of an image compressor. Thesis

    NASA Technical Reports Server (NTRS)

    Madani, Navid; Whitaker, Sterling

    1993-01-01

    The high initial cost of prototype Very Large Scaled Integrated (VLSI) parts requires that sufficient verifications be made to eliminate design errors before actually producing the prototypes. Logic simulation is the means by which the VLSI engineer can ensure that the design will function properly. The computer time required for logic simulation can be reduced through the use of behavioral models. Behavioral models, however, require time to write and verify and they do not always produce a dramatic speed up in logic simulation time. This paper presents a study of behavioral modeling aimed at discovering which circuit types benefit most from the use of behavioral models for logic simulation.