42 CFR 489.104 - Effective dates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Effective dates. 489.104 Section 489.104 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Advance Directives § 489.104 Effective...

42 CFR 489.35 - Notice to intermediary.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Notice to intermediary. 489.35 Section 489.35 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Allowable Charges § 489.35...

42 CFR 489.10 - Basic requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Basic requirements. 489.10 Section 489.10 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL General Provisions § 489.10 Basic...

42 CFR 489.28 - Special capitalization requirements for HHAs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Special capitalization requirements for HHAs. 489.28 Section 489.28 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND... Essentials of Provider Agreements § 489.28 Special capitalization requirements for HHAs. (a) Basic rule. An...

42 CFR 489.2 - Scope of part.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Scope of part. 489.2 Section 489.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL General Provisions § 489.2 Scope of part...

7 CFR 51.489 - Well netted.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false Well netted. 51.489 Section 51.489 Agriculture..., CERTIFICATION, AND STANDARDS) United States Standards for Grades of Cantaloups 1 Definitions § 51.489 Well netted. Well netted means that to an extent characteristic of the variety the cantaloup is well covered...

7 CFR 51.489 - Well netted.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false Well netted. 51.489 Section 51.489 Agriculture..., CERTIFICATION, AND STANDARDS) United States Standards for Grades of Cantaloups 1 Definitions § 51.489 Well netted. Well netted means that to an extent characteristic of the variety the cantaloup is well covered...

34 CFR 489.5 - What definitions apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What definitions apply? 489.5 Section 489.5 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM General § 489.5 What...

34 CFR 489.4 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false What regulations apply? 489.4 Section 489.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM General § 489.4 What...

Novel Conjugated Ladder-Structured Oligomer Anode with High Lithium Storage and Long Cycling Capability.

PubMed

Xie, Jian; Rui, Xianhong; Gu, Peiyang; Wu, Jiansheng; Xu, Zhichuan J; Yan, Qingyu; Zhang, Qichun

2016-07-06

Herein we report the development of nanostructured poly(1,4-dihydro-11H-pyrazino[2',3':3,4]cyclopenta[1,2-b]quinoxalin-11-one) (PPCQ), a novel conjugated ladderlike oligomer with the presence of a rich amount of heteroatoms, as the anode material. Beyond its remarkable lithium storage of 972 mAh g(-1) after 120 cycles, the superior cycle life and stable capacity performance of 489 mAh g(-1) revealed by ultralong testing of 1000 cycles (with an average Coulombic efficiency 99.8%) at a high current density of 2.5 A g(-1) indicate its excellent electrochemical stability to be promisingly applied for high-performance lithium-ion batteries (LIBs).

Drug Targets in Infections With Ebola and Marburg Viruses

DTIC Science & Technology

2009-01-01

Kew, M. C.; Bothwell, T . H.; Sher, R .; Miller, G. B.; Schneider, 1; Koomhof, H. 1; Gomperts, E. D.; Isaacson, M.; Gear, J. H. Br. Med. J., 1975,4(5995...489-93. [12] Smith, D, H.; Johnson, B. K.; Isaacson, M.; Swanapoel, R .; Johnson. K. M.; Killey, M.; Bagshawe, A; Siongok, T .; Keruga, W. K. Lancet...August 2007. Wkly Epidemiol Rec, 2007, 82(43) 381-4. (16] Towner, 1 S.; Khristova, M. L.; Sealy, T K.; Vincent, M. J.; Erickson, B. R .; Bawiec, D. A

19 CFR 4.89 - Vessels in foreign trade proceeding via domestic ports and touching at intermediate foreign ports.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Vessels in foreign trade proceeding via domestic ports and touching at intermediate foreign ports. 4.89 Section 4.89 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY VESSELS IN FOREIGN AND DOMESTIC TRADES Coastwise Procedure § 4.89...

Approved Drugs for Adults

MedlinePlus

... Us Quick Links What Is Hepatitis B? Prevention & Diagnosis Treatment & Management Resources & Support Research & Programs News & Events Contact Us Subscribe Disclaimer Privacy Policy 3805 Old Easton Road Doylestown, PA 18902 USA Phone: 215.489.4900 ...

KSC-98pc489

NASA Image and Video Library

1998-04-17

KENNEDY SPACE CENTER, FLA. -- STS-90 Mission Specialist Kathryn (Kay) Hire prepares for launch during suitup activities in the Operations and Checkout Building as Astronaut Support Personnel team member Heide Piper braids Hire's hair. Hire and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. Her first trip into space, Hire is participating in this life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.

Nonlinearities in personalization-privacy paradox in mHealth adoption: the mediating role of perceived usefulness and attitude.

PubMed

Zhang, Xiaofei; Guo, Xitong; Guo, Feng; Lai, Kee-Hung

2014-01-01

Personalization in healthcare refers to individualizing services and products based on patients' health conditions and interests. In order to deliver highly personalized offerings, mHealth providers need to use patients' health information, which provokes patients' concerns over personal health information leakage. So the personalization-privacy paradox is an important issue in the mHealth context. To gain a better understanding of this paradox, we take the personalization and privacy paradox factors as independent variables, incorporating the nonlinear relationships between personalization and privacy, and take attitude and perceived usefulness as middle variables to study mHealth adoption. The hypothesized model is tested through an empirical research of a 489-respondent sample in China. PLS is used for data analysis. (1) Personalization and privacy are found to influence mHealth adoption intention via attitude and perceived usefulness; (2) there is a substitution relationship, also called negative synergy between personalization and privacy in mHealth contexts; (3) attitude mediates the effect of perceived usefulness on intention, indicating a significant role of attitude.

42 CFR 489.57 - Reinstatement after termination.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Reinstatement after termination. 489.57 Section 489.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement...

42 CFR 489.57 - Reinstatement after termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Reinstatement after termination. 489.57 Section 489.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement...

42 CFR 489.69 - Evidence of compliance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Evidence of compliance. 489.69 Section 489.69 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.69 - Evidence of compliance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Evidence of compliance. 489.69 Section 489.69 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.21 - Specific limitations on charges.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Specific limitations on charges. 489.21 Section 489.21 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Essentials of Provider...

42 CFR 489.54 - Termination by the OIG.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Termination by the OIG. 489.54 Section 489.54 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement...

42 CFR 489.30 - Allowable charges: Deductibles and coinsurance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Allowable charges: Deductibles and coinsurance. 489.30 Section 489.30 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL...

42 CFR 489.21 - Specific limitations on charges.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Specific limitations on charges. 489.21 Section 489.21 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Essentials of Provider...

42 CFR 489.26 - Special requirements concerning veterans.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Special requirements concerning veterans. 489.26 Section 489.26 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Essentials of...

42 CFR 489.22 - Special provisions applicable to prepayment requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Special provisions applicable to prepayment requirements. 489.22 Section 489.22 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.22 - Special provisions applicable to prepayment requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Special provisions applicable to prepayment requirements. 489.22 Section 489.22 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.40 - Definition of incorrect collection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Definition of incorrect collection. 489.40 Section 489.40 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Handling of Incorrect...

42 CFR 489.40 - Definition of incorrect collection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Definition of incorrect collection. 489.40 Section 489.40 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Handling of Incorrect...

42 CFR 489.74 - Incorporation into existing provider agreements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Incorporation into existing provider agreements. 489.74 Section 489.74 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.30 - Allowable charges: Deductibles and coinsurance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Allowable charges: Deductibles and coinsurance. 489.30 Section 489.30 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL...

42 CFR 489.52 - Termination by the provider.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Termination by the provider. 489.52 Section 489.52 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement...

42 CFR 489.54 - Termination by the OIG.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Termination by the OIG. 489.54 Section 489.54 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement...

42 CFR 489.52 - Termination by the provider.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Termination by the provider. 489.52 Section 489.52 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement...

42 CFR 489.74 - Incorporation into existing provider agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Incorporation into existing provider agreements. 489.74 Section 489.74 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.53 - Termination by CMS.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Termination by CMS. 489.53 Section 489.53 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement and...

42 CFR 489.26 - Special requirements concerning veterans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Special requirements concerning veterans. 489.26... Provider Agreements § 489.26 Special requirements concerning veterans. For inpatient services, a hospital... concerning admissions practices and payment methodology and amounts. This section applies to services...

42 CFR 489.102 - Requirements for providers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Requirements for providers. 489.102 Section 489.102 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., nursing facilities, home health agencies, providers of home health care (and for Medicaid purposes...

42 CFR 489.102 - Requirements for providers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Requirements for providers. 489.102 Section 489.102 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., nursing facilities, home health agencies, providers of home health care (and for Medicaid purposes...

42 CFR 489.41 - Timing and methods of handling.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Timing and methods of handling. 489.41 Section 489.41 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Handling of Incorrect...

42 CFR 489.71 - Surety's standing to appeal Medicare determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Surety's standing to appeal Medicare determinations. 489.71 Section 489.71 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.61 - Basic requirement for surety bonds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Basic requirement for surety bonds. 489.61 Section 489.61 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.27 - Beneficiary notice of discharge rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Beneficiary notice of discharge rights. 489.27 Section 489.27 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Essentials of...

42 CFR 489.61 - Basic requirement for surety bonds.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Basic requirement for surety bonds. 489.61 Section 489.61 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.71 - Surety's standing to appeal Medicare determinations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Surety's standing to appeal Medicare determinations. 489.71 Section 489.71 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.62 - Requirement waived for Government-operated HHAs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Requirement waived for Government-operated HHAs. 489.62 Section 489.62 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.73 - Effect of conditions of payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Effect of conditions of payment. 489.73 Section 489.73 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.41 - Timing and methods of handling.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Timing and methods of handling. 489.41 Section 489.41 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Handling of Incorrect...

42 CFR 489.62 - Requirement waived for Government-operated HHAs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Requirement waived for Government-operated HHAs. 489.62 Section 489.62 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.63 - Parties to the bond.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Parties to the bond. 489.63 Section 489.63 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements for HHAs...

42 CFR 489.32 - Allowable charges: Noncovered and partially covered services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Allowable charges: Noncovered and partially covered services. 489.32 Section 489.32 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.65 - Amount of the bond.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Amount of the bond. 489.65 Section 489.65 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements for HHAs...

42 CFR 489.32 - Allowable charges: Noncovered and partially covered services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Allowable charges: Noncovered and partially covered services. 489.32 Section 489.32 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.63 - Parties to the bond.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Parties to the bond. 489.63 Section 489.63 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements for HHAs...

42 CFR 489.73 - Effect of conditions of payment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Effect of conditions of payment. 489.73 Section 489.73 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.25 - Special requirements concerning CHAMPUS and CHAMPVA programs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Special requirements concerning CHAMPUS and CHAMPVA programs. 489.25 Section 489.25 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.72 - Effect of review reversing determination.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Effect of review reversing determination. 489.72 Section 489.72 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond...

42 CFR 489.27 - Beneficiary notice of discharge rights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Beneficiary notice of discharge rights. 489.27 Section 489.27 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Essentials of...

42 CFR 489.65 - Amount of the bond.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Amount of the bond. 489.65 Section 489.65 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements for HHAs...

42 CFR 489.72 - Effect of review reversing determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Effect of review reversing determination. 489.72 Section 489.72 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond...

42 CFR 489.13 - Effective date of agreement or approval.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Effective date of agreement or approval. 489.13 Section 489.13 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL General...

42 CFR 489.25 - Special requirements concerning CHAMPUS and CHAMPVA programs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Special requirements concerning CHAMPUS and CHAMPVA programs. 489.25 Section 489.25 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

Mineralogy of the Dhofar 489 Lunar Meteorite, Crystalline Matrix Breccia with Magnesian Anorthositic Clasts

NASA Astrophysics Data System (ADS)

Takeda, H.; Saiki, K.; Ishii, T.; Otsuki, M.

2003-03-01

Dhofar 489, a crystalline matrix feldspathic breccia gives the mg# of mafic silicates higher than those of FAN trend in the An vs. mg# diagram, but D489 does not show granulitic texture. We examine the origin of this magnesian anorthosite.

42 CFR 489.2 - Scope of part.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Hospices. (7) Critical access hospital (CAHs). (8) Community mental health centers (CMHCs). (9) Religious... 42 Public Health 5 2010-10-01 2010-10-01 false Scope of part. 489.2 Section 489.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS...

42 CFR 489.66 - Additional requirements of the surety bond.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Additional requirements of the surety bond. 489.66 Section 489.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond...

42 CFR 489.64 - Authorized Surety and exclusion of surety companies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Authorized Surety and exclusion of surety companies. 489.64 Section 489.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.67 - Term and type of bond.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Term and type of bond. 489.67 Section 489.67 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements for HHAs...

42 CFR 489.55 - Exceptions to effective date of termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Exceptions to effective date of termination. 489.55 Section 489.55 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of...

42 CFR 489.34 - Allowable charges: Hospitals participating in State reimbursement control systems or...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Allowable charges: Hospitals participating in State reimbursement control systems or demonstration projects. 489.34 Section 489.34 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND...

42 CFR 489.64 - Authorized Surety and exclusion of surety companies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Authorized Surety and exclusion of surety companies. 489.64 Section 489.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety...

42 CFR 489.70 - Effect of payment by the Surety.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Effect of payment by the Surety. 489.70 Section 489.70 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.18 - Change of ownership or leasing: Effect on provider agreement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Change of ownership or leasing: Effect on provider agreement. 489.18 Section 489.18 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.42 - Payment of offset amounts to beneficiary or other person.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Payment of offset amounts to beneficiary or other person. 489.42 Section 489.42 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.70 - Effect of payment by the Surety.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Effect of payment by the Surety. 489.70 Section 489.70 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements...

42 CFR 489.34 - Allowable charges: Hospitals participating in State reimbursement control systems or...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Allowable charges: Hospitals participating in State reimbursement control systems or demonstration projects. 489.34 Section 489.34 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND...

42 CFR 489.11 - Acceptance of a provider as a participant.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Acceptance of a provider as a participant. 489.11 Section 489.11 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL General...

42 CFR 489.67 - Term and type of bond.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Term and type of bond. 489.67 Section 489.67 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Surety Bond Requirements for HHAs...

42 CFR 489.55 - Exceptions to effective date of termination.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Exceptions to effective date of termination. 489.55 Section 489.55 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of...

42 CFR 489.42 - Payment of offset amounts to beneficiary or other person.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Payment of offset amounts to beneficiary or other person. 489.42 Section 489.42 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER...

42 CFR 489.11 - Acceptance of a provider as a participant.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Acceptance of a provider as a participant. 489.11 Section 489.11 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL General...

34 CFR 489.3 - What activities may the Secretary fund?

Code of Federal Regulations, 2011 CFR

2011-07-01

... a particular case; and (iii) Adequate opportunities for appropriate education services and the... 34 Education 3 2011-07-01 2011-07-01 false What activities may the Secretary fund? 489.3 Section 489.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF...

42 CFR 489.1 - Statutory basis.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 5 2014-10-01 2014-10-01 false Statutory basis. 489.1 Section 489.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS... regulations for the administration of the Medicare program. (b) Although section 1866 of the Act speaks only...

42 CFR 489.1 - Statutory basis.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 5 2013-10-01 2013-10-01 false Statutory basis. 489.1 Section 489.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS... regulations for the administration of the Medicare program. (b) Although section 1866 of the Act speaks only...

42 CFR 489.1 - Statutory basis.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 5 2012-10-01 2012-10-01 false Statutory basis. 489.1 Section 489.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS... regulations for the administration of the Medicare program. (b) Although section 1866 of the Act speaks only...

34 CFR 489.2 - Who is eligible for a grant?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Who is eligible for a grant? 489.2 Section 489.2 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM...

42 CFR 489.13 - Effective date of agreement or approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... accreditation survey and accreditation decision. (2) Exceptions. (i) For an agreement with a community mental... 42 Public Health 5 2010-10-01 2010-10-01 false Effective date of agreement or approval. 489.13 Section 489.13 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN...

42 CFR 489.66 - Additional requirements of the surety bond.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Additional requirements of the surety bond. 489.66 Section 489.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... of this subpart, remains effective and the Surety remains liable for unpaid claims, civil money...

14 CFR 25.489 - Ground handling conditions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ground handling conditions. 25.489 Section... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Ground Loads § 25.489 Ground handling conditions... ground handling conditions). No wing lift may be considered. The shock absorbers and tires may be assumed...

14 CFR 25.489 - Ground handling conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Ground handling conditions. 25.489 Section... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Ground Loads § 25.489 Ground handling conditions... ground handling conditions). No wing lift may be considered. The shock absorbers and tires may be assumed...

42 CFR 489.1 - Statutory basis.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Statutory basis. 489.1 Section 489.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS... regulations for the administration of the Medicare program. (b) Although section 1866 of the Act speaks only...

42 CFR 489.1 - Statutory basis.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Statutory basis. 489.1 Section 489.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS... regulations for the administration of the Medicare program. (b) Although section 1866 of the Act speaks only...

M-X Environmental Technical Report. Environmental Characteristics of Alternative Designated Deployment Areas, Wildlife.

DTIC Science & Technology

1980-12-22

in avoidance of roads and, therefore, loss of habitat near roads (Rost and Bailey, 1979; Basile and Lonner, 1979). More discussion on individual... Pesticide Poisoning. Avian Diseases 28:487-489. Resource Area, Nye County, Nevada. Bureau of Land Management, Battle Mountain District. Rhoads, W.A

42 CFR 489.20 - Basic commitments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... section 1834(m)(4)(C)(ii)(VII) of the Act. (13) Those chemotherapy items identified, as of July 1, 1999... chemotherapy administration services identified, as of July 1, 1999, by HCPCS codes 36260-36262; 36489; 36530... this subchapter. The notice must indicate how the hospital will meet the medical needs of any patient...

Development of method of optimized flavor production systems design based on nano-emulsification Kawista (Feronia limonia) Fruit extraction

NASA Astrophysics Data System (ADS)

Suyanto, A.; Noor, E.; Fahma, F.; Rusli, M. S.; Djatna, T.

2018-01-01

‘Kawista’ (Feronia limonia) as a tropical fruit has unique flavor that can be applied as a flavor for food products. Flavor as volatile components are unstable by environment factors such as temperature and storage. Flavor nano emulsification form to improve the stability towards environment and increase its use in food products. Research carried out is system development of the nano emulsification Kawista extract flavor with sonication method. The best treatments are selected by Response Surface Methodology (RSM) for independent variable are amplitude (70-100%), time (90-150s) and temperature (5-45°C) controlled by the software of the device. The Flavor Extraction by maceration technique extended highest yield and flavor components. Nano-emulsions made with composition 1% (w/w) flavor extract, 2% (w/w) surfactant (tween 80), 0.25% Gum, and 96.75% (w/w) deionized water. The probe of sonication successfully for preparing stable O/W nano emulsions at amplitude, time and temperature 81.01%, 150s, 45°C, respectively. Characteristic of nano-emulsions i.e energy input (15.489J), viscosity (2.076 mPa.s), droplet size (13.446nm), and Polydispersity index (0.469).

34 CFR 489.10 - How does an eligible entity apply for a grant?

Code of Federal Regulations, 2010 CFR

2010-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS... at such time, in such manner, and containing such information as the Secretary may require, including... literacy programs authorized by § 489.1(a), including the annual reports required by § 489.30. (b) A...

42 CFR 489.31 - Allowable charges: Blood.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Allowable charges: Blood. 489.31 Section 489.31... Allowable charges: Blood. (a) Limitations on charges. (1) A provider may charge the beneficiary (or other person on his or her behalf) only for the first three pints of blood or units of packed red cells...

42 CFR 489.31 - Allowable charges: Blood.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Allowable charges: Blood. 489.31 Section 489.31... Allowable charges: Blood. (a) Limitations on charges. (1) A provider may charge the beneficiary (or other person on his or her behalf) only for the first three pints of blood or units of packed red cells...

42 CFR 489.31 - Allowable charges: Blood.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 5 2012-10-01 2012-10-01 false Allowable charges: Blood. 489.31 Section 489.31... Allowable charges: Blood. (a) Limitations on charges. (1) A provider may charge the beneficiary (or other person on his or her behalf) only for the first three pints of blood or units of packed red cells...

42 CFR 489.31 - Allowable charges: Blood.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 5 2014-10-01 2014-10-01 false Allowable charges: Blood. 489.31 Section 489.31... Allowable charges: Blood. (a) Limitations on charges. (1) A provider may charge the beneficiary (or other person on his or her behalf) only for the first three pints of blood or units of packed red cells...

42 CFR 489.31 - Allowable charges: Blood.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 5 2013-10-01 2013-10-01 false Allowable charges: Blood. 489.31 Section 489.31... Allowable charges: Blood. (a) Limitations on charges. (1) A provider may charge the beneficiary (or other person on his or her behalf) only for the first three pints of blood or units of packed red cells...

34 CFR 489.20 - How does the Secretary evaluate an application?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false How does the Secretary evaluate an application? 489.20 Section 489.20 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS...

34 CFR 489.10 - How does an eligible entity apply for a grant?

Code of Federal Regulations, 2011 CFR

2011-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS... at such time, in such manner, and containing such information as the Secretary may require, including... literacy programs authorized by § 489.1(a), including the annual reports required by § 489.30. (b) A...

34 CFR 489.10 - How does an eligible entity apply for a grant?

Code of Federal Regulations, 2013 CFR

2013-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS... at such time, in such manner, and containing such information as the Secretary may require, including... literacy programs authorized by § 489.1(a), including the annual reports required by § 489.30. (b) A...

34 CFR 489.10 - How does an eligible entity apply for a grant?

Code of Federal Regulations, 2014 CFR

2014-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS... at such time, in such manner, and containing such information as the Secretary may require, including... literacy programs authorized by § 489.1(a), including the annual reports required by § 489.30. (b) A...

34 CFR 489.10 - How does an eligible entity apply for a grant?

Code of Federal Regulations, 2012 CFR

2012-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS... at such time, in such manner, and containing such information as the Secretary may require, including... literacy programs authorized by § 489.1(a), including the annual reports required by § 489.30. (b) A...

Screening and Characterization of Oleaginous Microalgal Species from Northern Xinjiang.

PubMed

Wu, Lei; Xu, Liangliang; Hu, Chunxiang

2015-06-01

A total of 646 strains, including green algae and diatoms, were isolated from 220 samples to screen microalgae with high lipid productivity (LP). The samples were obtained from nine habitats in Northern Xinjiang, China in June 2013. This study initially identified eight lipidrich strains, namely, Desmodesmus intermedius XJ-498, D. intermedius XJ-145, D. intermedius XJ- 99, Monoraphidium pusillum XJ-489, M. dybowskii XJ-435, M. dybowskii XJ-151, Mychonastes homosphaera XJ-488, and Podohedriella falcata XJ-176, based on 18S rDNA sequencing. The strains were cultured in a photobioreactor for the same period. Results showed that the specific growth rate (day(-1)) of M. pusillum XJ-489 was the highest (1.14 ± 0.06), and the biomass concentration (g/l) of D. intermedius XJ-99 was the highest (2.84 ± 0.3). Futhermore, the lipid content (%) of M. dybowskii XJ-151 was the highest (33.5 ± 4.38), and the lipid productivity (mg l(-1) day(-1)) of My. homosphaera XJ-488 was the highest (86.41 ± 9.04). C16 to C18 accounted for 86% to 98% of the total lipid, and the biodiesel qualities of the selected algae corresponded to international standards. This study suggests that My. homosphaera XJ-488, D. intermedius XJ-99, and M. dybowskii XJ-151 are the most potential strains for biodiesel production among all the isolated strains.

GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chai, Peng, E-mail: chaiyisheng0508@sina.com; Tian, Jingzhong; Zhao, Deyin

Gse1 coiled-coil protein (GSE1), also known as KIAA0182, is a proline rich protein. However, the function of GSE1 is largely unknown. In this study, we reported that GSE1 is overexpression in breast cancer and silencing of GSE1 significantly suppressed breast cancer cells proliferation, migration and invasion. Furthermore, GSE1 was identified as a direct target of miR-489-5p, which is significantly reduced in breast cancer tissues. In addition, forced expression of miR-489-5p suppressed breast cancer cells proliferation, migration and invasion. Moreover, depletion of GSE1 by siRNAs significantly abrogated the enhanced proliferation, migration and invasion of breast cancer cells consequent to miR-489-5p depletion.more » Taken together, these findings suggest that GSE1 may function as a novel oncogene in breast cancer and it can be regulated by miR-489-5p. - Highlights: • GSE1 is overexpressed in breast cancer and increased GSE1 expression predicts poor prognosis in breast cancer patients. • Knockdown of GSE1 inhibits breast cancer cell proliferation, migration and invasion. • GSE1 is a direct target of miR-489-5p. • Forced expression of miR-489-5p inhibits breast cancer cell proliferation, migration and invasion.« less

42 CFR 489.12 - Decision to deny an agreement.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Compliance with civil rights requirements. CMS will not enter into a provider agreement if the provider fails to comply with civil rights requirements set forth in 45 CFR parts 80, 84, and 90, subject to the... 42 Public Health 5 2014-10-01 2014-10-01 false Decision to deny an agreement. 489.12 Section 489...

42 CFR 489.12 - Decision to deny an agreement.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Compliance with civil rights requirements. CMS will not enter into a provider agreement if the provider fails to comply with civil rights requirements set forth in 45 CFR parts 80, 84, and 90, subject to the... 42 Public Health 5 2012-10-01 2012-10-01 false Decision to deny an agreement. 489.12 Section 489...

42 CFR 489.12 - Decision to deny an agreement.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Compliance with civil rights requirements. CMS will not enter into a provider agreement if the provider fails to comply with civil rights requirements set forth in 45 CFR parts 80, 84, and 90, subject to the... 42 Public Health 5 2013-10-01 2013-10-01 false Decision to deny an agreement. 489.12 Section 489...

42 CFR 489.12 - Decision to deny an agreement.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Compliance with civil rights requirements. CMS will not enter into a provider agreement if the provider fails to comply with civil rights requirements set forth in 45 CFR parts 80, 84, and 90, subject to the... 42 Public Health 5 2011-10-01 2011-10-01 false Decision to deny an agreement. 489.12 Section 489...

42 CFR 489.23 - Specific limitation on charges for services provided to certain enrollees of fee-for-service FEHB...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Specific limitation on charges for services provided to certain enrollees of fee-for-service FEHB plans. 489.23 Section 489.23 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND...

42 CFR 489.23 - Specific limitation on charges for services provided to certain enrollees of fee-for-service FEHB...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Specific limitation on charges for services provided to certain enrollees of fee-for-service FEHB plans. 489.23 Section 489.23 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND...

42 CFR 489.68 - Effect of failure to obtain, maintain, and timely file a surety bond.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Effect of failure to obtain, maintain, and timely file a surety bond. 489.68 Section 489.68 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND...

42 CFR 489.68 - Effect of failure to obtain, maintain, and timely file a surety bond.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Effect of failure to obtain, maintain, and timely file a surety bond. 489.68 Section 489.68 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND...

38 CFR 4.89 - Ratings for inactive nonpulmonary tuberculosis in effect on August 19, 1968.

Code of Federal Regulations, 2010 CFR

2010-07-01

... nonpulmonary tuberculosis in effect on August 19, 1968. 4.89 Section 4.89 Pensions, Bonuses, and Veterans... tuberculosis in effect on August 19, 1968. Public Law 90-493 repealed section 356 of title 38, United States Code which provided graduated ratings for inactive tuberculosis. The repealed section, however, still...

38 CFR 4.89 - Ratings for inactive nonpulmonary tuberculosis in effect on August 19, 1968.

Code of Federal Regulations, 2013 CFR

2013-07-01

... nonpulmonary tuberculosis in effect on August 19, 1968. 4.89 Section 4.89 Pensions, Bonuses, and Veterans... tuberculosis in effect on August 19, 1968. Public Law 90-493 repealed section 356 of title 38, United States Code which provided graduated ratings for inactive tuberculosis. The repealed section, however, still...

38 CFR 4.89 - Ratings for inactive nonpulmonary tuberculosis in effect on August 19, 1968.

Code of Federal Regulations, 2011 CFR

2011-07-01

... nonpulmonary tuberculosis in effect on August 19, 1968. 4.89 Section 4.89 Pensions, Bonuses, and Veterans... tuberculosis in effect on August 19, 1968. Public Law 90-493 repealed section 356 of title 38, United States Code which provided graduated ratings for inactive tuberculosis. The repealed section, however, still...

38 CFR 4.89 - Ratings for inactive nonpulmonary tuberculosis in effect on August 19, 1968.

Code of Federal Regulations, 2012 CFR

2012-07-01

... nonpulmonary tuberculosis in effect on August 19, 1968. 4.89 Section 4.89 Pensions, Bonuses, and Veterans... tuberculosis in effect on August 19, 1968. Public Law 90-493 repealed section 356 of title 38, United States Code which provided graduated ratings for inactive tuberculosis. The repealed section, however, still...

38 CFR 4.89 - Ratings for inactive nonpulmonary tuberculosis in effect on August 19, 1968.

Code of Federal Regulations, 2014 CFR

2014-07-01

... nonpulmonary tuberculosis in effect on August 19, 1968. 4.89 Section 4.89 Pensions, Bonuses, and Veterans... tuberculosis in effect on August 19, 1968. Public Law 90-493 repealed section 356 of title 38, United States Code which provided graduated ratings for inactive tuberculosis. The repealed section, however, still...

The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype.

PubMed

Kudryashova, Elena; Struyk, Arie; Mokhonova, Ekaterina; Cannon, Stephen C; Spencer, Melissa J

2011-10-15

Mutations in tripartite motif protein 32 (TRIM32) are responsible for several hereditary disorders that include limb girdle muscular dystrophy type 2H (LGMD2H), sarcotubular myopathy (STM) and Bardet Biedl syndrome. Most LGMD2H mutations in TRIM32 are clustered in the NHL β-propeller domain at the C-terminus and are predicted to interfere with homodimerization. To get insight into TRIM32's role in the pathogenesis of LGMD2H and to create an accurate model of disease, we have generated a knock-in mouse (T32KI) carrying the c.1465G > A (p.D489N) mutation in murine Trim32 corresponding to the human LGMD2H/STM pathogenic mutation c.1459G > A (p.D487N). Our data indicate that T32KI mice have both a myopathic and a neurogenic phenotype, very similar to the one described in the Trim32-null mice that we created previously. Analysis of Trim32 gene expression in T32KI mice revealed normal mRNA levels, but a severe reduction in mutant TRIM32 (D489N) at the protein level. Our results suggest that the D489N pathogenic mutation destabilizes the protein, leading to its degradation, and results in the same mild myopathic and neurogenic phenotype as that found in Trim32-null mice. Thus, one potential mechanism of LGMD2H might be destabilization of mutated TRIM32 protein leading to a null phenotype.

42 CFR 489.20 - Basic commitments.

Code of Federal Regulations, 2013 CFR

2013-10-01

... section 1834(m)(4)(C)(ii)(VII) of the Act. (13) Those chemotherapy items identified, as of July 1, 1999... chemotherapy administration services identified, as of July 1, 1999, by HCPCS codes 36260-36262; 36489; 36530... the hospital 24 hours per day, 7 days per week, and must indicate how the hospital will meet the...

42 CFR 489.20 - Basic commitments.

Code of Federal Regulations, 2012 CFR

2012-10-01

... section 1834(m)(4)(C)(ii)(VII) of the Act. (13) Those chemotherapy items identified, as of July 1, 1999... chemotherapy administration services identified, as of July 1, 1999, by HCPCS codes 36260-36262; 36489; 36530... the hospital 24 hours per day, 7 days per week, and must indicate how the hospital will meet the...

42 CFR 489.20 - Basic commitments.

Code of Federal Regulations, 2014 CFR

2014-10-01

... section 1834(m)(4)(C)(ii)(VII) of the Act. (13) Those chemotherapy items identified, as of July 1, 1999... chemotherapy administration services identified, as of July 1, 1999, by HCPCS codes 36260-36262; 36489; 36530... the hospital 24 hours per day, 7 days per week, and must indicate how the hospital will meet the...

Dimensions of Family Connectedness among Adolescents with Mexican, Chinese, and European Backgrounds

ERIC Educational Resources Information Center

Hardway, Christina; Fuligni, Andrew J.

2006-01-01

Multiple dimensions of adolescents' connectedness with their families were investigated among 489 9th-grade students (M = 14.86 years) from families with Mexican, Chinese, and European backgrounds. Participants reported on various aspects of their family relationships and completed diary checklists of daily behaviors for a 2-week period. …

Disclosure to Parents about Everyday Activities among American Adolescents from Mexican, Chinese, and European Backgrounds

ERIC Educational Resources Information Center

Yau, Jenny P.; Tasopoulos-Chan, Marina; Smetana, Judith G.

2009-01-01

Disclosure to parents and reasons for not disclosing different activities were examined in 489 Chinese, Mexican, and European American adolescents (M = 16.37 years, SD = 0.77). With generational status controlled, Chinese American adolescents disclosed less to mothers about personal and multifaceted activities than European Americans and less…

A Biophysical-Computational Perspective of Breast Cancer Pathogenesis and Treatment Response

DTIC Science & Technology

2009-03-01

82. A.A. Rasmussen and K.J. Cullen, Breast Cancer Res Treat 47 (1998) 219- 33. 83. C. Kuperwasser, T. Chavarria, M. Wu, G. Magrane, J.W. Gray , L...24-34. 94. C.M. Lo, H.B. Wang, M. Dembo and Y.L. Wang, Biophys J 79 (2000) 144- 52. 95. D.S. Gray , J. Tien and C.S. Chen, J Biomed Mater Res A 66...Muller, G. Inghirami and F.G. Giancotti, Cell 126 (2006) 489-502. 103. C.C. Park, H. Zhang, M. Pallavicini, J.W. Gray , F. Baehner, C.J. Park and M.J

Streamlined Approach for Environmental Restoration Plan for Corrective Action Unit 489: WWII UXO Sites, Tonopah Test Range, Nevada; May 2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bechtel Nevada; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

2005-05-01

This Streamlined Approach for Environmental Restoration Plan provides the details for the closure of Corrective Action Unit (CAU) 489: WWII UXO Sites, Tonopah Test Range. CAU 489 is located at the Tonopah Test Range and is currently listed in Appendix III of the Federal Facility Agreement and Consent Order of 1996.

37 CFR 1.489 - Protest to lack of unity of invention before the International Preliminary Examining Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Protest to lack of unity of invention before the International Preliminary Examining Authority. 1.489 Section 1.489 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES International...

37 CFR 1.489 - Protest to lack of unity of invention before the International Preliminary Examining Authority.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Protest to lack of unity of invention before the International Preliminary Examining Authority. 1.489 Section 1.489 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES International...

37 CFR 1.489 - Protest to lack of unity of invention before the International Preliminary Examining Authority.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Protest to lack of unity of invention before the International Preliminary Examining Authority. 1.489 Section 1.489 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES International...

37 CFR 1.489 - Protest to lack of unity of invention before the International Preliminary Examining Authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Protest to lack of unity of invention before the International Preliminary Examining Authority. 1.489 Section 1.489 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES International...

37 CFR 1.489 - Protest to lack of unity of invention before the International Preliminary Examining Authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Protest to lack of unity of invention before the International Preliminary Examining Authority. 1.489 Section 1.489 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES International...

iTunes song-gifting is a low-cost, efficient recruitment tool to engage high-risk MSM in internet research.

PubMed

Holland, Christine M; Ritchie, Natalie D; Du Bois, Steve N

2015-10-01

This brief report describes methodology and results of a novel, efficient, and low-cost recruitment tool to engage high-risk MSM in online research. We developed an incentivization protocol using iTunes song-gifting to encourage participation of high-risk MSM in an Internet-based survey of HIV status, childhood sexual abuse, and adult behavior and functioning. Our recruitment methodology yielded 489 participants in 4.5 months at a total incentive cost of $1.43USD per participant. The sample comprised a critically high-risk group of MSM, including 71.0 % who reported recent condomless anal intercourse. We offer a "how-to" guide to aid future investigators in using iTunes song-gifting incentives.

17 CFR 230.489 - Filing of form by foreign banks and insurance companies and certain of their holding companies...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Filing of form by foreign banks and insurance companies and certain of their holding companies and finance subsidiaries. 230.489 Section 230.489 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 Investment...

7 CFR 51.489 - Well netted.

Code of Federal Regulations, 2010 CFR

2010-01-01

... FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) United States... characteristic of the variety the cantaloup is well covered with fully developed, well raised netting, some...

Thirty-Day Results for the Kelly Air Force Base Compressed Work Week Survey

DTIC Science & Technology

1992-11-01

Gummer, B. All that stresses does not strain: Job satisfaction, morale and turnover. Administration in Social Work, 3, 489-494, 1979. 5. Ivancevich , J.M...and Lyon , H.L. The shortened workweek: A field experi- ment. Journal of Applied Psychology, 62 (1), 34-37, 1977. 6. Latick, J.C. and Foster, L.W

Adolescent Hope as a Mediator between Parent-Child Connectedness and Adolescent Outcomes

ERIC Educational Resources Information Center

Padilla-Walker, Laura M.; Hardy, Sam A.; Christensen, Katherine J.

2011-01-01

This study examines adolescent hope as a mediator between connectedness to mother and father, and positive and negative child outcomes. Participants included 489 adolescents aged 9 to 14 years (M = 11.29; SD = 1.01) and their parents from the "Flourishing Families Project", and data were analyzed using structural equation modeling. Results…

Comparisons of Mineralogy of Lunar Meteorites Possibly from the Farside and The Kaguya Remote Sensing Data to Reconstruct the Earliest Anorthositic Crust of the Moon

NASA Technical Reports Server (NTRS)

Takeda, H.; Nagaoka, H.; Ohtake, M.; Kobayashi, S.; Yamaguchi, A.; Morota, T.; Karouji, Y.; Haruyma, J.; Katou, M.; Hiroi, T.;

Design, synthesis, and biological evaluation of 2-substituted-2,3,4,9-tetrahydrospiro-β-carboline-3-carboxylic acid derivatives as first-in-class mast cell stabilizers.

PubMed

Singh, Jatinder; Shah, Ramanpreet; Singh, Dhandeep; Jaggi, Amteshwar S; Singh, Nirmal

2018-05-01

Mast cell degranulation plays a momentous role in myriad diseases like asthma, eczema, allergic rhinitis, and conjunctivitis as well as anaphylactic shock; hence, there is an unmet need for developing new mast cells stabilizers. The reported mast cell stabilizers have a heterocyclic moiety and an acidic group. Furthermore, the role of tryptophan in suppression of mast cell activation is established. Hence, we prepared constrained analogs of tryptophan, which are derivatives of 2,3,4,9-tetrahydrospiro-β-carboline-3-carboxylic acid, and evaluated them for ex vivo inhibition of compound 48/80-induced mast degranulation activity. By comparing IC 50 (μM) values with that of the standard drug sodium cromoglycate (IC 50  = 0.489 ± 0.003 μM), compounds with bulky groups like heptyl (compound 9; IC 50  = 0.389 ± 0.015 μM) and octyl (compound 10; IC 50  = 0.354 ± 0.023 μM) were found to be of similar potency as sodium cromoglycate. Furthermore, the polar group-containing compounds like the chloropropyl (compound 16; IC 50  = 0.382 ± 0.083 μM) and benzoyl derivative (compound 14; IC 50  = 00.469 ± 0.032 μM) were also found to be of similar potency as sodium cromoglycate. This is a seminal study of spiro-β-carboline mast cell stabilization having a wider scope in mast cell research; yet, the mechanism of action remains elusive. © 2018 Deutsche Pharmazeutische Gesellschaft.

Prevention Tips

MedlinePlus

... Us Subscribe Disclaimer Privacy Policy 3805 Old Easton Road Doylestown, PA 18902 USA Phone: 215.489.4900 Fax: 215-489-4920 Contact Us Copyright © 2018 hepb.org Website Design & Website Hosting by IQnection

Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines.

PubMed

Mundalil Vasu, Mahesh; Anitha, Ayyappan; Takahashi, Taro; Thanseem, Ismail; Iwata, Keiko; Asakawa, Tetsuya; Suzuki, Katsuaki

2016-01-01

Evidence suggests neuroprotective effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on the developed neurons in the adult brain. In contrast, the drug may be deleterious to immature or undifferentiated neural cells, although the mechanism is unclear. Recent investigations have suggested that microRNAs (miRNA) may be critical for effectiveness of psychotropic drugs including SSRI. We investigated whether fluoxetine could modulate expressions of neurologically relevant miRNAs in two neuroblastoma SK-N-SH and SH-SY5Y cell lines. Initial screening results revealed that three (miR-489, miR-572 and miR-663a) and four (miR-320a, miR-489, miR-572 and miR-663a) miRNAs were up-regulated in SK-N-SH cells and SH-SY5Y cells, respectively, after 24 hours treatment of fluoxetine (1-25 μM). Cell viability was reduced according to the dose of fluoxetine. The upregulation of miR-572 and miR-663a was consistent in both the SH-SY5Y and SK-N-SH cells, confirmed by a larger scale culture condition. Our data is the first in vitro evidence that fluoxetine could increase the expression of miRNAs in undifferentiated neural cells, and that putative target genes of those miRNAs have been shown to be involved in fundamental neurodevelopmental processes.

34 CFR 489.4 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM General § 489.4 What regulations apply? The following regulations apply to the Functional Literacy for State and Local Prisoners...

Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter V. Appendices.

DTIC Science & Technology

1980-12-01

Analysis of the White Pine Power Project. Bureau of Business and Economic Research, University of Nevada, Reno. Basile , J. V., and T. N. Lonner, 1979...Suspected of Pesticide Poisoning. Avian Diseases 18:487-489. Resource Area, Nye County, Nevada. Bureau of Land Management, Battle Mountain District. Rhoads, W

Recent advances in environmental data mining

NASA Astrophysics Data System (ADS)

Leuenberger, Michael; Kanevski, Mikhail

2016-04-01

Due to the large amount and complexity of data available nowadays in geo- and environmental sciences, we face the need to develop and incorporate more robust and efficient methods for their analysis, modelling and visualization. An important part of these developments deals with an elaboration and application of a contemporary and coherent methodology following the process from data collection to the justification and communication of the results. Recent fundamental progress in machine learning (ML) can considerably contribute to the development of the emerging field - environmental data science. The present research highlights and investigates the different issues that can occur when dealing with environmental data mining using cutting-edge machine learning algorithms. In particular, the main attention is paid to the description of the self-consistent methodology and two efficient algorithms - Random Forest (RF, Breiman, 2001) and Extreme Learning Machines (ELM, Huang et al., 2006), which recently gained a great popularity. Despite the fact that they are based on two different concepts, i.e. decision trees vs artificial neural networks, they both propose promising results for complex, high dimensional and non-linear data modelling. In addition, the study discusses several important issues of data driven modelling, including feature selection and uncertainties. The approach considered is accompanied by simulated and real data case studies from renewable resources assessment and natural hazards tasks. In conclusion, the current challenges and future developments in statistical environmental data learning are discussed. References - Breiman, L., 2001. Random Forests. Machine Learning 45 (1), 5-32. - Huang, G.-B., Zhu, Q.-Y., Siew, C.-K., 2006. Extreme learning machine: theory and applications. Neurocomputing 70 (1-3), 489-501. - Kanevski, M., Pozdnoukhov, A., Timonin, V., 2009. Machine Learning for Spatial Environmental Data. EPFL Press; Lausanne, Switzerland, p.392. - Leuenberger, M., Kanevski, M., 2015. Extreme Learning Machines for spatial environmental data. Computers and Geosciences 85, 64-73.

Human Factors Research in Aircrew Performance and Training

DTIC Science & Technology

1986-11-01

at Fort Devens , Massachusetts. During the evaluation, the project director observed the techniques used by the team members to assess specific...Szabo, Editors Anacapa Sciences, Inc. for ARI Field Unit at Fort Rucker, Alabama Charles A. Gainer, Chief 4-. TRAINING RESEARCH LABORATORY Jack H...DATE ARI Field Unit at Fort Rucker, Alabama November 1986 P.O. Box 489; Fort Rucker, AL 36362 22. NUMBEROrPAGES 2,2 14. MONITORING AGENCY NAME & ADDRESS

Concepts for the Development of a Nondestructive Testing and Evaluation System for Rigid Airfield Pavements.

DTIC Science & Technology

1985-01-01

T01A 141 401 619 4.89 3.38 2.98 3.71 4.18 3.83 T03A 41 488 708 5.09 5.09 5.09 42 347 564 2.52 2.52 43 406 695 4.98 4.98 T05A 39 537 757 5.74 5.75 5.75...r N0fl Nl 0 P NN0N eNON,0 f0NrO N 0200 gomlf Onnin 1n00 0000 nOwo aNt 0 cu1-W O l Mef 0qb (A vN N flONQ N N* N NNM ycN ty ,NN c 0 0 0 mNf YOJ l PN 0

Intracellular Protein Delivery for Treating Breast Cancer

DTIC Science & Technology

2014-08-01

protein derived from chicken anemia virus (Backendorf et al., 2008). When transgenically expressed, apoptin can induce p53-independent apoptosis in a...and sho quantified b each figure cell lines He nes HeLa er S-S Rho signals rem re well-shie cessible to rong red flu pping of rh e of the nuc s...Jochemsen, A.G., Vandereb, A.J., and Noteborn, M.H.M. (1995). Apoptin, a Protein- Derived from Chicken Anemia Virus, Induces P53-Independent Apoptosis in Human Osteosarcoma Cells. Cancer Res 55, 486-489.

Development of a predictive energy equation for maintenance hemodialysis patients: a pilot study.

PubMed

Byham-Gray, Laura; Parrott, J Scott; Ho, Wai Yin; Sundell, Mary B; Ikizler, T Alp

2014-01-01

The study objectives were to explore the predictors of measured resting energy expenditure (mREE) among a sample of maintenance hemodialysis (MHD) patients, to generate a predictive energy equation (MHDE), and to compare such models to another commonly used predictive energy equation in nutritional care, the Mifflin-St. Jeor equation (MSJE). The study was a retrospective, cross-sectional cohort design conducted at the Vanderbilt University Medical Center. Study subjects were adult MHD patients (N = 67). Data collected from several clinical trials were analyzed using Pearson's correlation and multivariate linear regression procedures. Demographic, anthropometric, clinical, and laboratory data were examined as potential predictors of mREE. Limits of agreement between the MHDE and the MSJE were evaluated using Bland-Altman plots. The a priori α was set at P < .05. The main outcome measure was mREE. The mean age of the sample was 47 ± 13 years. Fifty participants (75.6%) were African American, 7.5% were Hispanic, and 73.1% were males. Fat-free mass (FFM), serum albumin (ALB), age, weight, serum creatinine (CR), height, body mass index, sex, high-sensitivity C-reactive protein (CRP), and fat mass (FM) were all significantly (P < .05) correlated with mREE. After screening for multi-collinearity, the best predictive model (MHDE-lean body mass [LBM]) of mREE included (R(2) = 0.489) FFM, ALB, age, and CRP. Two additional models (MHDE-CRP and MHDE-CR) with acceptable predictability (R(2) = 0.460 and R(2) = 0.451) were derived to improve the clinical utility of the developed energy equation (MHDE-LBM). Using Bland-Altman plots, the MHDE over- and underpredicted mREE less often than the MSJE. Predictive models (MHDE) including selective demographic, clinical, and anthropometric data explained less than 50% variance of mREE but had better precision in determining energy requirements for MHD patients when compared with MSJE. Further research is necessary to improve predictive models of mREE in the MHD population and to test its validity and clinical application. Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Genomics and Comparative Genomic Analyses Provide Insight into the Taxonomy and Pathogenic Potential of Novel Emmonsia Pathogens.

PubMed

Yang, Ying; Ye, Qiang; Li, Kang; Li, Zongwei; Bo, Xiaochen; Li, Zhen; Xu, Yingchun; Wang, Shengqi; Wang, Peng; Chen, Huipeng; Wang, Junzhi

2017-01-01

Over the last 50 years, newly described species of Emmonsia -like fungi have been implicated globally as sources of systemic human mycosis (emmonsiosis). Their ability to convert into yeast-like cells capable of replication and extra-pulmonary dissemination during the course of infection differentiates them from classical Emmonsia species. Immunocompromised patients are at highest risk of emmonsiosis and exhibit high mortality rates. In order to investigate the molecular basis for pathogenicity of the newly described Emmonsia species, genomic sequencing and comparative genomic analyses of Emmonsia sp. 5z489, which was isolated from a non-deliberately immunosuppressed diabetic patient in China and represents a novel seventh isolate of Emmonsia -like fungi, was performed. The genome size of 5z489 was 35.5 Mbp in length, which is ~5 Mbp larger than other Emmonsia strains. Further, 9,188 protein genes were predicted in the 5z489 genome and 16% of the assembly was identified as repetitive elements, which is the largest abundance in Emmonsia species. Phylogenetic analyses based on whole genome data classified 5z489 and CAC-2015a, another novel isolate, as members of the genus Emmonsia . Our analyses showed that divergences among Emmonsia occurred much earlier than other genera within the family Ajellomycetaceae, suggesting relatively distant evolutionary relationships among the genus. Through comparisons of Emmonsia species, we discovered significant pathogenicity characteristics within the genus as well as putative virulence factors that may play a role in the infection and pathogenicity of the novel Emmonsia strains. Moreover, our analyses revealed a novel distribution mode of DNA methylation patterns across the genome of 5z489, with >50% of methylated bases located in intergenic regions. These methylation patterns differ considerably from other reported fungi, where most methylation occurs in repetitive loci. It is unclear if this difference is related to physiological adaptations of new Emmonsia , but this question warrants further investigation. Overall, our analyses provide a framework from which to further study the evolutionary dynamics of Emmonsia strains and identity the underlying molecular mechanisms that determine the infectious and pathogenic potency of these fungal pathogens, and also provide insight into potential targets for therapeutic intervention of emmonsiosis and further research.

Results of Student Evaluation of Instruction (SEOI), Fall 2009

ERIC Educational Resources Information Center

Houston Community College System, Office of Institutional Research, 2010

2010-01-01

The "Student Evaluation of Instruction" (SEOI) was administered to all full-time and part-time faculty. Approximately 105,475 surveys were sent out in 5,489 envelopes; 66,790 surveys were returned to the Office of Institutional Research. The return rate for the SEOI packet envelopes was 81.0%. The instructors' reports were provided to…

[Complaints of low back pain among private farmers exposed to whole body vibration].

PubMed

Solecki, Leszek

2014-01-01

Work-related lower back disorders, which involve the lumbo-sacral region, as well as injuries of the lumbar section of the spine, are a serious and constantly growing problem in Europe. Whole body vibration is one of the major hazardous factors suspected of the development of back pain. The study covered a selected group of males, 98 farmers (aged 55.3 +/- 10.1) from the area of 7 communes in the Lublin Region, engaged in the mixed agricultural production (plant-animal). The control group consisted of 40 academic workers (university and research institute employees) aged 48.9 +/- 9.6 years. A questionnaire concerning low back pain (in the lumbar region) designed by the researchers of the Institute of Rural Health in Lublin was used as a major research tool. The degree of farmers' exposure to whole body vibration was evaluated based on the parameter known as a cumulative vibration dose (d) (years x m2 x s(-1)). The measurements showed that the cumulative vibration dose for the selected group of farmers (98) remained within the range of 2.90-9.68 (years x m2 x s(-1)), in the time interval between 15-50 years of work in conditions of exposure to vibration. The survey confirmed that private farmers exposed to whole body vibration considerably more frequently complained of back pain (92 farmers, 94% of the total number of respondents), than academic workers (control group not exposed to whole body vibration (25 researchers, 63%); p < 0.0001. Also the frequency of back pain in all the three time intervals of employment (15-25, 26-35, 36-50 years) is significantly higher in the group of farmers than in the control group (p < 0.05). The frequency of back pains experienced by farmers during the entire period of occupational activity increases with a growing dose of whole body vibration (p = 0.005). In the incidence of chronic pain an upward tendency was observed (statistically insignificant).

Structural monitoring of Rigolets Pass Bridge : LTRC technical summary report 437.

DOT National Transportation Integrated Search

2009-09-01

The Louisiana Department of Transportation and Development (LADOTD) has been gradually : introducing high performance concrete (HPC) into their bridge construction programs. The : Rigolets Pass Bridge is a 62-span bridge with a total length of 5,489 ...

Effect of Stress-Strain Behavior on Low-Cycle Fatigue of Alpha-Beta Titanium Alloys.

DTIC Science & Technology

1980-11-21

and strain excursion, such a curve would appear to fit much of the high temperature hold-time data compiled by Krempl and Wundt [21]. Thus, it might...34Mechanische Relaxation von Kupfer-Einkristallen," Phys. Stat. Sol. 3, 111-120. 21. Krempl, E. and Wundt , B. M., (1971), Hold-Time Effects in High- Temperature Low-Cycle Fatigue, ASTM STP 489. 26 Low

[Assessment on vegetation restoration capacity of several grassland ecosystems under destroyed disturbance in permafrost regions of Qinghai-Tibet Plateau].

PubMed

Li, Dong-Ming; Guo, Zheng-Gang; An, Li-Zhe

2008-10-01

Vegetation restoration capacity of disturbed grassland ecosystem is one of the important components in assessing the influence of human engineering activities on the grassland ecosystems in permafrost region of Qinghai-Tibet Plateau. After comparing the features of vegetation communities, plant species diversity, grassland primary productivity, and economic group between disturbed and undisturbed communities, the comprehensive vegetation restoration capacity of several grassland communities under destroyed disturbance was assessed by using comprehensive assessment index. The results showed that the restoration of cover and community composition was obvious after 26 years natural restoration, being better for alpine steppes than for alpine meadows. However, the cover of disturbed communities was less than that of undisturbed communities. The restoration of plant species diversity in Stipa purpurea steppe was better than that in other grassland types. The biomass of standing plants restored from 0 to 148.8-489.6 g x m(-2), and that of Kobresia tibetica meadow was the highest (489.6 g x m(-2)). The palatable plants of disturbed communities were lower than those of undisturbed communities except for K. tibetica meadow, in which, the palatable plants were not changeable between disturbed and undisturbed communities. The comprehensive vegetation restoration capacity of alpine steppes was better than that of alpine meadows.

Study of Environmental Data Complexity using Extreme Learning Machine

NASA Astrophysics Data System (ADS)

Leuenberger, Michael; Kanevski, Mikhail

2017-04-01

The main goals of environmental data science using machine learning algorithm deal, in a broad sense, around the calibration, the prediction and the visualization of hidden relationship between input and output variables. In order to optimize the models and to understand the phenomenon under study, the characterization of the complexity (at different levels) should be taken into account. Therefore, the identification of the linear or non-linear behavior between input and output variables adds valuable information for the knowledge of the phenomenon complexity. The present research highlights and investigates the different issues that can occur when identifying the complexity (linear/non-linear) of environmental data using machine learning algorithm. In particular, the main attention is paid to the description of a self-consistent methodology for the use of Extreme Learning Machines (ELM, Huang et al., 2006), which recently gained a great popularity. By applying two ELM models (with linear and non-linear activation functions) and by comparing their efficiency, quantification of the linearity can be evaluated. The considered approach is accompanied by simulated and real high dimensional and multivariate data case studies. In conclusion, the current challenges and future development in complexity quantification using environmental data mining are discussed. References - Huang, G.-B., Zhu, Q.-Y., Siew, C.-K., 2006. Extreme learning machine: theory and applications. Neurocomputing 70 (1-3), 489-501. - Kanevski, M., Pozdnoukhov, A., Timonin, V., 2009. Machine Learning for Spatial Environmental Data. EPFL Press; Lausanne, Switzerland, p.392. - Leuenberger, M., Kanevski, M., 2015. Extreme Learning Machines for spatial environmental data. Computers and Geosciences 85, 64-73.

Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents

PubMed Central

Chen, Jianjun; Wang, Zhao; Li, Chien-Ming; Lu, Yan; Vaddady, Pavan K.; Meibohm, Bernd; Dalton, James T.; Miller, Duane D.; Li, Wei

2010-01-01

A series of 2-aryl-4-benzoyl-imidazoles (ABI) was synthesized as a result of structural modifications based on the previous set of 2-aryl-imidazole-4-carboxylic amide (AICA) derivatives and 4-substituted methoxylbenzoyl-aryl-thiazoles (SMART). The average IC50 of the most active compound (5da) was 15.7 nM. ABI analogs have substantially improved aqueous solubility (48.9 μg/mL for 5ga vs. 0.909 μg/mL for SMART-1, 0.137 μg/mL for paclitaxel, and 1.04 μg/mL for Combretastatin A4). Mechanism of action studies indicate that the anticancer activity of ABI analogs is through inhibition of tubulin polymerization by interacting with the colchicine binding site. Unlike paclitaxel and colchicine, the ABI compounds were equally potent against multidrug resistant cancer cells and the sensitive parental melanoma cancer cells. In vivo results indicated that 5cb was more effective than DTIC in inhibiting melanoma xenograph tumor growth. Our results suggest that the novel ABI compounds may be developed to effectively treat drug-resistant tumors. PMID:20919720

Compositional analysis of Hyperion with the Cassini Visual and Infrared Mapping Spectrometer

NASA Astrophysics Data System (ADS)

Brad Dalton, J.; Cruikshank, Dale P.; Clark, Roger N.

2012-08-01

Compositional mapping of the surface of Hyperion using Cassini Visual and Infrared Mapping Spectrometer (VIMS) observations reveals a heterogeneous surface dominated by water ice accompanied by additional materials. Carbon dioxide, as evidenced by a prominent absorption band centered at 4.26 μm, is distributed over most of the surface, including icy regions. This does not represent exposures of pure CO2 ice, but concentrations of CO2 molecules adsorbed on other materials or complexed in H2O, perhaps as a clathrate (Cruikshank, D.P., Meyer, A.W., Brown, R.H., Clark, R.N., Jaumann, R., Stephan, K., Hibbitts, C.A., Sandford, S.A., Mastrapa, R., Filacchione, G., Dalle Ore, C.M., Nicholson, P.D., Buratti, B.J., McCord, T.B., Nelson, R.M., Dalton, J.B., Baines, K.H., Matson, D.L., The VIMS Team [2010]. Icarus 206, 561-572). Localized deposits of low-albedo material in subcircular depressions exhibit spectral absorptions indicative of C-H in aromatic (3.29 μm) and aliphatic (3.35-3.50 μm) hydrocarbons. An absorption band at 2.42 μm that is also seen on other saturnian satellites, tentatively identified as H2 (Clark, R.N. et al. [2011]. In: Proc. AAS-DPS Meeting, 43, 1563; Clark et al., in preparation, 2012) adsorbed on dark material grains, is also prominent. Our best spectral models included H2O and CO2 ice, with small amounts of nanophase Fe and Fe2O3. Weaker and more spatially scattered absorption features are also found at 4.48, 4.60, and 4.89 μm, although no clear molecular identifications have yet been made. While strongest in the low-albedo deposits, the CO2, hydrocarbon and putative H2 bands vary in strength throughout the icy regions, as do the 4.48-, 4.60- and 4.89-μm bands, suggesting that this background ice is laced with a complex mixture of non-ice compounds.

Anomalous Li Storage Capability in Atomically Thin Two-Dimensional Sheets of Nonlayered MoO2.

PubMed

Xia, Chuan; Zhou, Yungang; Velusamy, Dhinesh Babu; Farah, Abdiaziz A; Li, Peng; Jiang, Qiu; Odeh, Ihab N; Wang, Zhiguo; Zhang, Xixiang; Alshareef, Husam N

2018-02-14

Since the first exfoliation and identification of graphene in 2004, research on layered ultrathin two-dimensional (2D) nanomaterials has achieved remarkable progress. Realizing the special importance of 2D geometry, we demonstrate that the controlled synthesis of nonlayered nanomaterials in 2D geometry can yield some unique properties that otherwise cannot be achieved in these nonlayered systems. Herein, we report a systematic study involving theoretical and experimental approaches to evaluate the Li-ion storage capability in 2D atomic sheets of nonlayered molybdenum dioxide (MoO 2 ). We develop a novel monomer-assisted reduction process to produce high quality 2D sheets of nonlayered MoO 2 . When used as lithium-ion battery (LIB) anodes, these ultrathin 2D-MoO 2 electrodes demonstrate extraordinary reversible capacity, as high as 1516 mAh g -1 after 100 cycles at the current rate of 100 mA g -1 and 489 mAh g -1 after 1050 cycles at 1000 mA g -1 . It is evident that these ultrathin 2D sheets did not follow the normal intercalation-cum-conversion mechanism when used as LIB anodes, which was observed for their bulk analogue. Our ex situ XPS and XRD studies reveal a Li-storage mechanism in these 2D-MoO 2 sheets consisting of an intercalation reaction and the formation of metallic Li phase. In addition, the 2D-MoO 2 based microsupercapacitors exhibit high areal capacitance (63.1 mF cm -2 at 0.1 mA cm -2 ), good rate performance (81% retention from 0.1 to 2 mA cm -2 ), and superior cycle stability (86% retention after 10,000 cycles). We believe that our work identifies a new pathway to make 2D nanostructures from nonlayered compounds, which results in an extremely enhanced energy storage capability.

The Relationship of Head Start Teachers' Academic Language Use and Children's Receptive Vocabulary

ERIC Educational Resources Information Center

Barnes, Erica M.; Dickinson, David K.

2017-01-01

Research Findings: This study examines lexical- and sentence-level dimensions of academic language to describe teachers' natural use of academic language and its association with vocabulary growth in 489 at-risk 4-year-olds enrolled in Head Start preschool classrooms. Using transcripts derived from video recordings of book-reading sessions in 52…

34 CFR 489.5 - What definitions apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM General § 489.5 What...— Functional literacy means at least an eighth grade equivalence, or a functional criterion score, on a nationally recognized literacy assessment. Local correctional agency means any agency of local government...

CRC/EORTC/NCI Joint Formulation Working Party: experiences in the formulation of investigational cytotoxic drugs.

PubMed Central

Beijnen, J. H.; Flora, K. P.; Halbert, G. W.; Henrar, R. E.; Slack, J. A.

1995-01-01

The pharmaceutical formulation of a new anti-tumour agent has often been perceived as the bottleneck in anti-cancer drug development. In order to increase the speed of this essential development step, the Cancer Research Campaign (CRC), the European Organization for Research and Treatment of Cancer (EORTC) and the National Cancer Institute (NCI) agreed in 1987 to form the Joint Formulation Working Party (JFWP). The main goal of the JFWP is to facilitate the rapid progress of a new drug through pharmaceutical developmental to preclinical toxicology and subsequently to phase I clinical trial. Under the auspices of the JFWP around 50 new agents have been developed or are currently in development. In this report we present our formulation experiences since the establishment of the JFWP with a selected number of agents: aphidicolin glycinate, bryostatin 1, carmethizole, carzelesin, combretastatin A4, dabis maleate, disulphonated aluminium phthalocyanine, E.O.9, 4-hydroxyanisole, pancratistatin, rhizoxin, Springer pro-drug, SRI 62-834, temozolomide, trimelamol and V489. The approaches used and problems presented may be of general interest to scientists in related fields and those considering submitting agents for development. PMID:7599054

The Effects of Thermal Barrier Coating, Common-Rail Injection, and Reduced Compression Ratio on the Efficiency of Single-Cylinder Diesel Engines

DTIC Science & Technology

2010-05-12

m) YXX:........................................Molar Fraction of Compound XX 12 1 Introduction and Background Small internal combustion...Heywood, John B. Internal Combustion Engine Fundamentals. New York: McGraw-Hill, 1988. [9] Judge, A.W. High Speed Diesel Engines. London...performance and exergy potential of the exhaust gas. Energy Conversion and Management 46:489-499. [11] Parlak A., Yasar H., and Sahin B. 2003. Performance

42 CFR 489.12 - Decision to deny an agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

....12 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL General Provisions § 489.12... § 420.204 of this chapter); (2) The prospective provider has failed to disclose ownership and control...

Melanin as an active layer in biosensors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piacenti da Silva, Marina, E-mail: marinaness@yahoo.com; Congiu, Mirko, E-mail: congiumat@gmail.com; Oliveira Graeff, Carlos Frederico de, E-mail: graeff@fc.unesp.br

2014-03-15

The development of pH sensors is of great interest due to its extensive application in several areas such as industrial processes, biochemistry and particularly medical diagnostics. In this study, the pH sensing properties of an extended gate field effect transistor (EGFET) based on melanin thin films as active layer are investigated and the physical mechanisms related to the device operation are discussed. Thin films were produced from different melanin precursors on indium tin oxide (ITO) and gold substrates and were investigated by Atomic Force Microscopy and Electrochemical Impedance Spectroscopy. Experiments were performed in the pH range from 2 to 12.more » EGFETs with melanin deposited on ITO and on gold substrates showed sensitivities ranging from 31.3 mV/pH to 48.9 mV/pH, depending on the melanin precursor and the substrate used. The pH detection is associated with specific binding sites in its structure, hydroxyl groups and quinone imine.« less

Accreting Black Holes an All Out Effort

NASA Technical Reports Server (NTRS)

2003-01-01

This final report lists many publications resulting from this grant. The following is a representative listing of several dozen title: (1) '1100 Days of BATSE observations of Cyg X-1', D Crary, C. Kouveliotou, J. van Paradijs, F. v.d. Hooft, B. Rubin, S. Zhang, W. Paciesas, M. Fini:er, B. Harmon, M. v.d. Klis, W.H.G. Lewin, and J. Norris, Astron. Astrophys. Suppl., 120, 153-156, (1997) (2) 'Spectral and Temporal Variability in the X-ray Flux'. of GSll24-683, Nova Muscae 1991", M. Takizawa, T. Dotani, K. Mitsuda, E. Matsuba, M. O;;awa, T. Aoki, K. Asai, K. Ebisawa, K. Makishima, S. Miyamoto, S . Iga, B. Vaughan, R. Rc.tledge, & W. Lewin, Astrophys, J., 489, 272, (1997).

47 CFR 0.489 - Applications for ship radio inspection and periodical survey.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Applications for ship radio inspection and... Taking Examinations § 0.489 Applications for ship radio inspection and periodical survey. Applications for ship radio inspection or for periodical survey shall be forwarded to the radio district office...

Maxima and O-C Diagrams for 489 Mira Stars

NASA Astrophysics Data System (ADS)

Karlsson, T.

2013-11-01

Maxima for 489 Mira stars have been compiled. They were computed with data from AAVSO, AFOEV, VSOLJ, and BAA-VSS and collected from published maxima. The result is presented in a mysql database and on web pages with O-C diagrams, periods and some statistical information for each star.

A Research Report of Small/Rural School Districts in New Mexico Compared to School Districts of Similiar Size Nationwide.

ERIC Educational Resources Information Center

Barker, Bruce O.; Muse, Ivan D.

A 1982-83 survey produced data used to compare 17 small/rural K-12 New Mexico school districts (900 students or fewer) with 642 similar districts nationwide. Of New Mexico's 88 school districts, 43 were identified as qualifying (48.9%, enrolling 16,648 students), for comparison to 4,125 similar districts nationwide. A questionnaire mailed to…

Cross-Cultural Validation of Teachers' Sense of Efficacy Scale in Three Asian Countries: Test of Measurement Invariance

ERIC Educational Resources Information Center

Ruan, Jiening; Nie, Youyan; Hong, Ji; Monobe, Gumiko; Zheng, Guomin; Kambara, Hitomi; You, Sula

2015-01-01

The purpose of this study is to validate the widely adopted Teachers' Sense of Efficacy Scale (TSES) for the East Asian context. The researchers seek to find out whether TSES holds validity and reliability and is appropriate for use to measure teacher efficacy in China, Korea, and Japan. 489 teachers from the three countries participated in the…

Effects of Parental Monitoring and Exposure to Community Violence on Antisocial Behavior and Anxiety/Depression among Adolescents

ERIC Educational Resources Information Center

Bacchini, Dario; Miranda, Maria Concetta; Affuso, Gaetana

2011-01-01

The aim of the research was to investigate the influence of gender, exposure to community violence, and parental monitoring upon antisocial behavior and anxiety/depression in adolescence. Involved in the study were 489 adolescents (290 males and 189 females) from 4 secondary schools in the city of Naples, Italy. The age of participants ranged from…

Non-invasive timing of gas gun projectiles with light detection and ranging

NASA Astrophysics Data System (ADS)

Goodwin, P. M.; Bartram, B. D.; Gibson, L. L.; Wu, M.; Dattelbaum, D. M.

2014-05-01

We have developed a Light Detection and Ranging (LIDAR) diagnostic to track the position of a projectile inside of a gas gun launch tube in real-time. This capability permits the generation of precisely timed trigger pulses useful for triggering high-latency diagnostics such as a flash lamp-pumped laser. An initial feasibility test was performed using a 72 mm bore diameter single-stage gas gun routinely used for dynamic research at Los Alamos. A 655 nm pulsed diode laser operating at a pulse repetition rate of 100 kHz was used to interrogate the position of the moving projectile in real-time. The position of the projectile in the gun barrel was tracked over a distance of ~ 3 meters prior to impact. The position record showed that the projectile moved at a velocity of 489 m/s prior to impacting the target. This velocity was in good agreement with independent measurements of the projectile velocity by photon Doppler velocimetry and timing of the passage of the projectile through optical marker beams positioned at the muzzle of the gun. The time-to-amplitude conversion electronics used enable the LIDAR data to be processed in real-time to generate trigger pulses at preset separations between the projectile and target.

Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies

PubMed Central

Zhu, Zhongyu; Chakraborti, Samitabh; He, Yuxian; Roberts, Anjeanette; Sheahan, Tim; Xiao, Xiaodong; Hensley, Lisa E.; Prabakaran, Ponraj; Rockx, Barry; Sidorov, Igor A.; Corti, Davide; Vogel, Leatrice; Feng, Yang; Kim, Jae-Ouk; Wang, Lin-Fa; Baric, Ralph; Lanzavecchia, Antonio; Curtis, Kristopher M.; Nabel, Gary J.; Subbarao, Kanta; Jiang, Shibo; Dimitrov, Dimiter S.

2007-01-01

The severe acute respiratory syndrome coronavirus (SARS-CoV) caused a worldwide epidemic in late 2002/early 2003 and a second outbreak in the winter of 2003/2004 by an independent animal-to-human transmission. The GD03 strain, which was isolated from an index patient of the second outbreak, was reported to resist neutralization by the human monoclonal antibodies (hmAbs) 80R and S3.1, which can potently neutralize isolates from the first outbreak. Here we report that two hmAbs, m396 and S230.15, potently neutralized GD03 and representative isolates from the first SARS outbreak (Urbani, Tor2) and from palm civets (SZ3, SZ16). These antibodies also protected mice challenged with the Urbani or recombinant viruses bearing the GD03 and SZ16 spike (S) glycoproteins. Both antibodies competed with the SARS-CoV receptor, ACE2, for binding to the receptor-binding domain (RBD), suggesting a mechanism of neutralization that involves interference with the SARS-CoV–ACE2 interaction. Two putative hot-spot residues in the RBD (Ile-489 and Tyr-491) were identified within the SARS-CoV spike that likely contribute to most of the m396-binding energy. Residues Ile-489 and Tyr-491 are highly conserved within the SARS-CoV spike, indicating a possible mechanism of the m396 cross-reactivity. Sequence analysis and mutagenesis data show that m396 might neutralize all zoonotic and epidemic SARS-CoV isolates with known sequences, except strains derived from bats. These antibodies exhibit cross-reactivity against isolates from the two SARS outbreaks and palm civets and could have potential applications for diagnosis, prophylaxis, and treatment of SARS-CoV infections. PMID:17620608

34 CFR 489.30 - What annual report is required?

Code of Federal Regulations, 2010 CFR

2010-07-01

... literacy; (7) Data on all direct and indirect costs of the program; and (8) Information on progress toward... ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM What... close of the first calendar year in which a literacy program authorized by § 489.1 is placed in...

38 CFR 1.489 - Audit and evaluation activities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... GENERAL PROVISIONS Disclosures Without Patient Consent § 1.489 Audit and evaluation activities. Subject to....584, and the following paragraphs, patient medical records covered by §§ 1.460 through 1.499 of this...) Records not copies. If patient records covered by §§ 1.460 through 1.499 of this part are not copied...

40 CFR 60.489a - List of chemicals produced by affected facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 7 2014-07-01 2014-07-01 false List of chemicals produced by affected... Equipment Leaks of VOC in the Synthetic Organic Chemicals Manufacturing Industry for Which Construction, Reconstruction, or Modification Commenced After November 7, 2006 § 60.489a List of chemicals produced by affected...

49 CFR 192.489 - Remedial measures: Cast iron and ductile iron pipelines.

Code of Federal Regulations, 2011 CFR

2011-10-01

... for Corrosion Control § 192.489 Remedial measures: Cast iron and ductile iron pipelines. (a) General graphitization. Each segment of cast iron or ductile iron pipe on which general graphitization is found to a... 49 Transportation 3 2011-10-01 2011-10-01 false Remedial measures: Cast iron and ductile iron...

49 CFR 192.489 - Remedial measures: Cast iron and ductile iron pipelines.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for Corrosion Control § 192.489 Remedial measures: Cast iron and ductile iron pipelines. (a) General graphitization. Each segment of cast iron or ductile iron pipe on which general graphitization is found to a... 49 Transportation 3 2010-10-01 2010-10-01 false Remedial measures: Cast iron and ductile iron...

34 CFR 489.30 - What annual report is required?

Code of Federal Regulations, 2011 CFR

2011-07-01

... literacy; (7) Data on all direct and indirect costs of the program; and (8) Information on progress toward... ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM What... close of the first calendar year in which a literacy program authorized by § 489.1 is placed in...

34 CFR 489.30 - What annual report is required?

Code of Federal Regulations, 2014 CFR

2014-07-01

... literacy; (7) Data on all direct and indirect costs of the program; and (8) Information on progress toward... ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM What... close of the first calendar year in which a literacy program authorized by § 489.1 is placed in...

34 CFR 489.30 - What annual report is required?

Code of Federal Regulations, 2012 CFR

2012-07-01

... literacy; (7) Data on all direct and indirect costs of the program; and (8) Information on progress toward... ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM What... close of the first calendar year in which a literacy program authorized by § 489.1 is placed in...

34 CFR 489.30 - What annual report is required?

Code of Federal Regulations, 2013 CFR

2013-07-01

... literacy; (7) Data on all direct and indirect costs of the program; and (8) Information on progress toward... ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM What... close of the first calendar year in which a literacy program authorized by § 489.1 is placed in...

Post-treatment PSA < or = 0.2 ng/mL defines disease freedom after radiotherapy for prostate cancer using modern techniques.

PubMed

Critz, F A; Williams, W H; Holladay, C T; Levinson, A K; Benton, J B; Holladay, D A; Schnell, F J; Maxa, L S; Shrake, P D

1999-12-01

The prostate-specific antigen (PSA) definition of disease freedom after radiotherapy for prostate cancer is still in dispute. This report focuses on the PSA nadir achieved in men treated by modern radiotherapy techniques. From 1984 to 1994, 489 consecutive men with clinical Stage T1 -T2 prostate cancer were treated by simultaneous radiation: prostate iodine-125 implant followed by external beam radiation. A transperineal implant was performed on 143 men with Stage T1-T2NX, the focus of this study; 346 men with Stage T1-T2N0 had a retropubic implant. The median pretreatment PSA was 8.3 ng/mL (range 0.3 to 188). A rising PSA was defined as one that rose on three consecutive occasions above whatever nadir was achieved. A minimum 5-year follow-up (range 5 to 15) was reached by 453 men. After a minimum 5-year follow-up, 336 men had a nonrising PSA, and of this group, 107 had undergone simultaneous radiation by the transperineal implant technique. A PSA nadir of 0.2 ng/mL or less was achieved by 97% of the transperineally implanted men, and 3% had a nadir of 0.3 to 1.0 ng/mL. Of the 489 men, those who had a nadir of 0.2 ng/mL or less had a 92% nonrising PSA rate (P = 0.001) 10 years after treatment compared with a 41% rate for men who had a nadir of 0.3 to 1.0 ng/mL. All men whose nadir was greater than 1.0 ng/mL had recurrence. The median time to achieve the PSA nadir of 0.2 ng/mL was 27 months (range 3 to 102). Primarily on the basis of the results from men treated with simultaneous radiation using the transperineal technique, the definition of disease freedom for radiotherapy should be men who achieve and maintain a PSA nadir of 0.2 ng/mL or less.

17 CFR 230.489 - Filing of form by foreign banks and insurance companies and certain of their holding companies...

Code of Federal Regulations, 2014 CFR

2014-04-01

... banks and insurance companies and certain of their holding companies and finance subsidiaries. 230.489... form by foreign banks and insurance companies and certain of their holding companies and finance... that is a foreign bank or foreign insurance company excepted from the definition of investment company...

17 CFR 230.489 - Filing of form by foreign banks and insurance companies and certain of their holding companies...

Code of Federal Regulations, 2011 CFR

2011-04-01

... banks and insurance companies and certain of their holding companies and finance subsidiaries. 230.489... form by foreign banks and insurance companies and certain of their holding companies and finance... that is a foreign bank or foreign insurance company excepted from the definition of investment company...

17 CFR 230.489 - Filing of form by foreign banks and insurance companies and certain of their holding companies...

Code of Federal Regulations, 2013 CFR

2013-04-01

... banks and insurance companies and certain of their holding companies and finance subsidiaries. 230.489... form by foreign banks and insurance companies and certain of their holding companies and finance... that is a foreign bank or foreign insurance company excepted from the definition of investment company...

17 CFR 230.489 - Filing of form by foreign banks and insurance companies and certain of their holding companies...

Code of Federal Regulations, 2012 CFR

2012-04-01

... banks and insurance companies and certain of their holding companies and finance subsidiaries. 230.489... form by foreign banks and insurance companies and certain of their holding companies and finance... that is a foreign bank or foreign insurance company excepted from the definition of investment company...

34 CFR 489.1 - What is the Functional Literacy for State and Local Prisoners Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Functional Literacy for State and Local... (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION FUNCTIONAL LITERACY FOR STATE AND LOCAL PRISONERS PROGRAM General § 489.1 What is the Functional Literacy for State and Local...

Fact File: Crime Data from 489 U.S. College and Universities.

ERIC Educational Resources Information Center

Chronicle of Higher Education, 1997

1997-01-01

Data on crime at 489 colleges and universities with over 5,000 enrollment are presented for 1994 and 1995. Reported incidents of murder, forcible sex offenses, non-forcible sex offenses, robbery, aggravated assault, burglary, and motor-vehicle theft and arrests for liquor-law violations, drugs, and weapons are included. Institutions are listed by…

Doing More with Less: Cost-effective, Compact Particle Accelerators (489th Brookhaven Lecture)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trbojevic, Dejan

2013-10-22

Replace a 135-ton magnet used for cancer-fighting particle therapies with a magnet that weighs only two tons? Such a swap is becoming possible thanks to new particle accelerator advances being developed by researchers at Brookhaven Lab. With an approach that combines techniques used by synchrotron accelerators with the ability to accept more energy, these new technologies could be used for more than fighting cancer. They could also decrease the lifecycle of byproducts from nuclear power plants and reduce costs for eRHIC—a proposed electron-ion collider for Brookhaven Lab that researchers from around the world would use to explore the glue thatmore » holds together the universe’s most basic building blocks and explore the proton-spin puzzle. During this lecture, Dr. Trbojevic provides an overview of accelerator technologies and techniques—particularly a non-scaling, fixed-focused alternating gradient—to focus particle beams using fewer, smaller magnets. He discusses how these technologies will benefit eRHIC and other applications, including particle therapies being developed to combat cancer.« less

Collection and evaluation of epididymal sperm in captive agoutis (Dasyprocta aguti).

PubMed

Ferraz, M S; de Menezes, D J A; Pessoa, G T; Cabral, R M; Illera, M J; Silva, A R; Carvalho, M A M

2011-02-01

The objective was to establish a protocol for the collection and evaluation of epididymal sperm in agoutis. Eight males (1-2 y old) underwent left orchidectomy and epididymal sperma were collected by retrograde flush. Average values were flush volume 32 μL, pH 6.9, sperm concentration 748 x 10(6) sperm/mL, with motility 86.5% and vigor 4.6. Viable sperm were present in all flush samples; 66% of sperm were alive, and 41.9% of sperm responded positively to the hypoosmotic test (using distilled water). There were 21.1% morphologically abnormal sperm, of which 2.0 and 19.1% were primary and secondary defects, respectively. The acrosome was intact in 99.5% of sperm. The sperm head was 4.89 ± 0.41 μm long and 3.13 ± 0.35 μm wide, with an area of 13.01 ± 2.01 μm(2). Midpieces were 5.33 ± 0.44 μm long and 0.98 ± 0.13 wide, sperm tails were 29.91 ± 2.29 μm, and overall sperm length was 40.12 ± 2.44 μm. In conclusion, epididymal sperm collection from agoutis was satisfactory; the collected sperm has the potential to be stored, facilitating development of other reproductive biotechnologies for this species. Copyright © 2011 Elsevier Inc. All rights reserved.

1.65μm (H-band) surface photometry of galaxies. II. Observations of 297 galaxies with the TIRGO 1.5m telescope.

NASA Astrophysics Data System (ADS)

Gavazzi, G.; Pierini, D.; Baffa, C.; Lisi, F.; Hunt, L. K.; Randone, I.; Boselli, A.

1996-12-01

We present near-infrared H-band (1.65μm) surface photometry of 297 galaxies (mostly) in the Coma Supercluster obtained with the Arcetri NICMOS3 camera, ARNICA, mounted on the Gornergrat Infrared Telescope. Magnitudes and diameters within the 21.5mag/arcsec^2^ isophote, concentration indices, and total H magnitudes are derived. Combining these observations with those obtained similarly using the Calar Alto telescopes (Paper I, 1996A&AS..120..489G) we find a strong positive correlation between the near-infrared concentration index and the galaxy H-band luminosity, and we analyze the consequent dependence of near-infrared growth-curves on H-band luminosity.

Hepatoprotective triterpenoids and lignans from the stems of Schisandra pubescens.

PubMed

Wang, Guo-Wei; Deng, Li-Qing; Luo, You-Ping; Liao, Zhi-Hua; Chen, Min

2017-08-01

One new triterpenoid (1) and 13 known compounds (2-14) were isolated from Schisandra pubescens stems. The structure of the new compound was established on the basis of 1D/2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were evaluated for their hepatoprotective activities against D-GalN-induced cell injury in QSG7701 cells. Compounds 1, 13 and 14 at 10 μM showed hepatoprotective activities, with survival rates of 60.5, 50.4 and 48.9%, respectively.

Adult Diabetic Patients’ Self-Care Levels, Attitudes, and Perceptions Following an Education Program.

DTIC Science & Technology

1983-01-01

hospital. Diabetes care, 1981, 4,. 487-489. Graber, A. L., Christman, B. G., Alogna, M, T., & Davidson, J. K. Evaluation of diabetes patient - education programs...L. Why patient education ? An elookate thow doatientwt diabeter elts c:j~inlHat Nurs ngOulo, 1979, 27, 71-75 7-11. Leie .(E..Idviulzn.hea.• atrt-ne...Salzer, J. E. Classes to improve diabetic self-care. American Journal of Nursing, 1975, 75, 1324-1326. Svtall, D. A patient education program. American

Behavioral Hyperventilation and Central Sleep Apnea in Two Children

PubMed Central

Johnston, Thomas P.; Tam-Williams, Jade; Schmandt, Margaret; Patel, Anand C.; Cleveland, Claudia; Coste, Ferdinand; Kemp, James S.

2015-01-01

Behavioral hyperventilation is a rarely recognized cause of central sleep apnea (CSA) among children. We report two pediatric patients who presented with prolonged central sleep apnea secondary to behavioral hyperventilation. One patient also had a prolonged corrected QT (QTC) interval resulting from hyperventilation. Citation: Johnston TP, Tam-Williams J, Schmandt M, Patel AC, Cleveland C, Coste F, Kemp JS. Behavioral hyperventilation and central sleep apnea in two children. J Clin Sleep Med 2015;11(4):487–489. PMID:26106657

The association between birth order, sibship size and glioma development in adulthood.

PubMed

Amirian, E; Scheurer, Michael E; Bondy, Melissa L

2010-06-01

The etiology of brain tumors is still largely unknown. Previous research indicates that infectious agents and immunological characteristics may influence adult glioma risk. The purpose of our study was to evaluate the effects of birth order and sibship size (total number of siblings), as indicators of the timing and frequency of early life infections, on adult glioma risk using a population of 489 cases and 540 cancer-free controls from the Harris County Brain Tumor Study. Odds ratios for birth order and sibship size were calculated separately from multivariable logistic regression models, adjusting for sex, family history of cancer, education, and age. Each one-unit increase in birth order confers a 13% decreased risk of glioma development in adulthood (OR = 0.87, 95% CI = 0.79-0.97). However, sibship size was not significantly associated with adult glioma status (OR = 0.97, 95% CI = 0.91-1.04). Our study indicates that individuals who were more likely to develop common childhood infections at an earlier age (those with a higher birth order) may be more protected against developing glioma in adulthood. More biological and epidemiological research is warranted to clarify the exact mechanisms through which the timing of common childhood infections and the course of early life immune development affect gliomagenesis.

76 FR 38613 - Initiation of Five-Year (“Sunset”) Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

.... Alloy Steel Pipe (3rd Review). A-580-809 731-TA-533 South Korea Circular Welded Non- David Goldberger, (202) 482-4136. Alloy Steel Pipe (3rd Review). A-489-501 731-TA-273 Turkey Welded Carbon Steel David Goldberger, (202) 482-4136. Pipe & Tube (3rd Review). C-489-502 701-TA-253 Turkey Welded Carbon Steel David...

76 FR 78321 - Proposed Collection; Comment Request;

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-16

..., Washington, DC 20549-0213. Extension: Rule 489 and Form F-N; SEC File No. 270-361; OMB Control No. 3235-0411... U.S.C. 80a-1 et seq.) to file Form F-N (17 CFR 239.43) to appoint an agent for service of process..., approximately 13 entities were required by rule 489 to make 15 Form F-N submissions. The Commission has...

Determination of the delta(18O/16O)of Water: RSIL Lab Code 489

USGS Publications Warehouse

Revesz, Kinga; Coplen, Tyler

2008-01-01

The purpose of the technique described by the Reston Stable Isotope Laboratory (RSIL) lab code 489 is to present a method to determine the delta(180/160), abbreviated as delta-180, of water. This delta-18O measurement of water also is a component of National Water Quality Laboratory (NWQL in USGS) schedules 1142 and 1172. Water samples are loaded into glass sample containers on a vacuum manifold to equilibrate gaseous CO2 at constant temperature (25 deg C) with water samples. After loading water samples on the vacuum manifold, air is evacuated through capillary to avoid evaporation, and CO2 is added. The samples are shaken to increase the equilibration rate of water and CO2. When isotopic equilibrium has been attained, an aliquot of CO2 is extracted sequentially from each sample container, separated from water vapor by means of a dry ice trap, and introduced into a dual-inlet isotope-ratio mass spectrometer (DI-IRMS) for determination of the delta-18O value. There is oxygen isotopic fractionation between water and CO2, but it is constant at constant temperature. The DI-IRMS is a DuPont double-focusing mass spectrometer. It has a double collector. One ion beam passes through a slit in a forward collector and is collected in the rear collector. The other ion beams are collected in the front collector. The instrument is capable of measuring mass/charge (m/z) 44 and 45 or 44 and 46 by changing the ion-accelerating voltage under computer control. The ion beams from these m/z values are as follows: m/z 44=CO2=12C16O16O, m/z 45=CO2=13C16O16O primarily, and m/z 46 = CO2=12C16O18O primarily. The data acquisition and control software calculates delta-18O values.

[Regional specific differences in prevalence of overweight/obesity in China: findings from China Kadoorie Biobank study in 10 areas in China].

PubMed

Wang, Lixiang; Lyu, Jun; Guo, Yu; Bian, Zheng; Yu, Canqing; Zhou, Huiyan; Tan, Yunlong; Pei, Pei; Chen, Junshi; Chen, Zhengming; Li, Liming

2015-11-01

To describe gender and regional differences in the prevalence of overweight/obesity in adults found by China Kadoorie Biobank (CKB) study, involving 512 489 adults, in 10 areas in China. The baseline survey of CKB was conducted in 5 urban areas and 5 rural areas in China during 2004-2008. After excluding those with extreme value of BMI (<15.0 kg/m(2) or >50 kg/m(2)), 512 489 subjects were included in the analysis. Overweight/obesity was classified according to BMI and WC, and diagnosed according to the guideline for prevention and control of overweight/obesity in Chinese adults. The gender and regional specific distributions of overweight/obesity were compared after adjusting for age. The overall prevalence of overweight/obesity was higher in females (45.3%) than in males (41.7%), and the prevalence of central obesity was also higher in females (44.6%) than in males (38.3%). Both the prevalence of overweight/obesity (66.9% in males and 67.5% in females) and the central obesity (63.3% in males and 64.9% in females) were highest in Qingdao. The area specific difference in the prevalence was more obvious in males than in females. Rural areas all had the low prevalence except Henan. Moreover, central obesity was diagnosed in some subjects (15.3% in females, 9.8% in males) with normal/low BMI (<24.0 kg/m(2)). This phenomenon was more obvious in Qingdao (22.2% in males and 23.2% in females). The prevalence of overweight/obesity in adults varied greatly across different areas in China.

Noninvasive monitoring of intraocular pharmacokinetics of daunorubicin using fluorophotometry.

PubMed

Kizhakkethara, I; Li, X; el-Sayed, S; Khoobehi, B; Moshfeghi, D M; Rahimy, M; Peyman, G A

Daunorubicin is a cytotoxic drug, which, in nontoxic doses, is effective in preventing cellular proliferation in experimental vitreoretinopathy. We studied dose and clearance of daunorubicin in various ocular tissues using fluorophotometry techniques. In vitro tests: The emission of fluorescence from the daunorubicin solution having a concentration range of 0.1 to 10 micrograms/mL in phosphate buffer was measured using an excitation wavelength range of 489 +/- 10 nm. The emission of fluorescence was measured at 514 nm; the linearity of the response was determined using linear regression analysis. There is a fluorescence peak of daunorubicin at 485 nm. The validity and reproducibility of the method were examined. In vivo tests: The rabbits were randomized into three groups and daunorubicin concentrations of 4, 6, or 8 micrograms/mL were injected into the vitreous. Fluorophotometry scanning from the retina to the anterior chamber was performed with a commercially available fluorophotometer at various times up to 48 hours after injection to quantify fluorescence emission of daunorubicin. The standard curve of fluorescence versus concentration of daunorubicin was linear in the range of 0.1 to 8 micrograms/mL. It was sensitive up to 0.1 microgram. The daunorubicin time concentration profile showed a dose response relationship over the 48-hour period studied. The half-life of daunorubicin in the vitreous was about 5 hours. We performed fluorophotometry using a fluorophotometer whose exciter emits light at 489 nm, which is very close to an absorption peak of daunorubicin. These two values are close enough to obviate the need for modifying the commercial fluorophotometer. Therefore the concentration of daunorubicin in the vitreous cavity can be measured noninvasively.

2012 ESTCP Live Site Demonstrations Massachusetts Military Reservation Camp Edwards, MA. ESTCP MR-1165 Demonstration Data Report Central Impact Area TEMTADS MP 2x2 Cart Survey

DTIC Science & Technology

2013-01-31

372,250.272 4,618,632.972 0.30 Horizontal Across Track T-004 Blank 372,252.872 4,618,629.872 N/A N/A N/A T-005 Medium ISO 372,255.575 4,618,626.492...4.46 4.89 4.668 0.12 1.33 1.40 1.36 0.03 1.24 1.30 1.27 0.02 Med. ISO 1.69 1.77 1.73 0.031 0.94 1.01 0.98 0.02 0.92 0.96 0.94 0.01 Figure 5-9...1.00 0.5 155mmP -2.70 -0.90 -1.80 0.5 81mmM -3.50 -2.00 -3.00 0.4 Med. ISO 0.80 2.10 1.50 0.4 S ho tp ut 15 5m m P 81 m m M M ed . I S O M ag ne

Internet-Based Education for Prostrate Cancer Screening. Addendum

DTIC Science & Technology

2010-12-01

a randomized trial among primary care patients with low health literacy . Patient Education and Counseling, 73(3), 482-489. Appendix 1) Complete...patients with low health literacy . Patient Educ Couns 2008, 73:482-489. 39. Davison BJ, Kirk P, Degner LF, Hassard TH: Information and patient...Carey LA, et al: Retention and use of breast cancer recurrence risk information from genomic tests: the role of health literacy . Cancer Epidemiol

Development of a Test Method for the Evaluation of DNA Damage in Mouse Spermatogonial Stem Cells

PubMed Central

Jeon, Hye Lyun; Yi, Jung-Sun; Kim, Tae Sung; Oh, Youkyung; Lee, Hye Jeong; Lee, Minseong; Bang, Jin Seok; Ko, Kinarm; Ahn, Il Young; Ko, Kyungyuk; Kim, Joohwan; Park, Hye-Kyung; Lee, Jong Kwon; Sohn, Soo Jung

2017-01-01

Although alternative test methods based on the 3Rs (Replacement, Reduction, Refinement) are being developed to replace animal testing in reproductive and developmental toxicology, they are still in an early stage. Consequently, we aimed to develop alternative test methods in male animals using mouse spermatogonial stem cells (mSSCs). Here, we modified the OECD TG 489 and optimized the in vitro comet assay in our previous study. This study aimed to verify the validity of in vitro tests involving mSSCs by comparing their results with those of in vivo tests using C57BL/6 mice by gavage. We selected hydroxyurea (HU), which is known to chemically induce male reproductive toxicity. The 50% inhibitory concentration (IC50) value of HU was 0.9 mM, as determined by the MTT assay. In the in vitro comet assay, % tail DNA and Olive tail moment (OTM) after HU administration increased significantly, compared to the control. Annexin V, PI staining and TUNEL assays showed that HU caused apoptosis in mSSCs. In order to compare in vitro tests with in vivo tests, the same substances were administered to male C57BL/6 mice. Reproductive toxicity was observed at 25, 50, 100, and 200 mg/kg/day as measured by clinical measures of reduction in sperm motility and testicular weight. The comet assay, DCFH-DA assay, H&E staining, and TUNEL assay were also performed. The results of the test with C57BL/6 mice were similar to those with mSSCs for HU treatment. Finally, linear regression analysis showed a strong positive correlation between results of in vitro tests and those of in vivo. In conclusion, the present study is the first to demonstrate the effect of HU-induced DNA damage, ROS formation, and apoptosis in mSSCs. Further, the results of the current study suggest that mSSCs could be a useful model to predict male reproductive toxicity. PMID:28443181

Prospective evaluation of IOTA logistic regression models LR1 and LR2 in comparison with subjective pattern recognition for diagnosis of ovarian cancer in an outpatient setting.

PubMed

Nunes, N; Ambler, G; Foo, X; Widschwendter, M; Jurkovic, D

2018-06-01

To determine whether International Ovarian Tumor Analysis (IOTA) logistic regression models LR1 and LR2 developed for the preoperative diagnosis of ovarian cancer could also be used to differentiate between benign and malignant adnexal tumors in the population of women attending gynecology outpatient clinics. This was a single-center prospective observational study of consecutive women attending our gynecological diagnostic outpatient unit, recruited between May 2009 and January 2012. All the women were first examined by a Level-II ultrasound operator. In those diagnosed with adnexal tumors, the IOTA-LR1/2 protocol was used to evaluate the masses. The LR1 and LR2 models were then used to assess the risk of malignancy. Subsequently, the women were also examined by a Level-III examiner, who used pattern recognition to differentiate between benign and malignant tumors. Women with an ultrasound diagnosis of malignancy were offered surgery, while asymptomatic women with presumed benign lesions were offered conservative management with a minimum follow-up of 12 months. The initial diagnosis was compared with two reference standards: histological findings and/or a comparative assessment of tumor morphology on follow-up ultrasound scans. All women for whom the tumor classification on follow-up changed from benign to malignant were offered surgery. In the final analysis, 489 women who had either or both of the reference standards were included. Their mean age was 50 years (range, 16-91 years) and 45% were postmenopausal. Of the included women, 342/489 (69.9%) had surgery and 147/489 (30.1%) were managed conservatively. The malignancy rate was 137/489 (28.0%). Overall, sensitivities of LR1 and LR2 for the diagnosis of malignancy were 97.1% (95% CI, 92.7-99.2%) and 94.9% (95% CI, 89.8-97.9%) and specificities were 77.3% (95% CI, 72.5-81.5%) and 76.7% (95% CI, 71.9-81.0%), respectively (P > 0.05). In comparison with pattern recognition (sensitivity 94.2% (95% CI, 88.8-97.4%), specificity 96.3% (95% CI, 93.8-98.0%)), the specificities of the IOTA models were significantly lower (P < 0.0001). A significantly higher number of women would have been offered surgery for suspected cancer if the women had been assessed using the IOTA models instead of pattern recognition (213/489 (43.6%) vs 142/489 (29.0%); P < 0.001). The IOTA models maintained their high sensitivity when used in an outpatient setting. Specificity was relatively low, which indicates that a significant proportion of the women would have been offered unnecessary surgery for suspected ovarian cancer. These findings show that the IOTA models could be used as a first-stage test to diagnose ovarian cancer in an outpatient setting, but a different second-stage test is required to minimize the number of false-positive findings. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

Effect of the Agricultural Biomass Burning on the Ambient Air Quality of Lumbini

NASA Astrophysics Data System (ADS)

Mehra, M.; Panday, A. K.; Praveen, P. S.; Bhujel, A.; Pokhrel, S.; Ram, K.

2017-12-01

The emissions from increasing anthropogenic activities has led to degradation in ambient air quality of Lumbini (UNESCO world heritage site) and its surrounding environments. The presence of high concentrations of air pollutants is of concern because of its implications for public health, atmospheric visibility, chemistry, crop yield, weather and climate on a local to regional scale. The study region experiences wide-spread on-field agricultural residue burning, particularly in the months of November (paddy residue burning) and April (wheat residue burning). In an attempt to study the impact of emissions from post-harvest burning of paddy and wheat residue in Nepal, the International Centre for Integrated Mountain Development, in collaboration with the Government of Nepal's Department of Environment and the Lumbini International Research Institute, established the Lumbini Air Quality Observatory (LAQO) in May 2016 for continuous measurement of Black carbon (BC), particulate matter (PM10, PM2.5 & PM1), as well as concentration of gaseous pollutant and meteorological parameters. Here we present results of the surface observations from LAQO for the months with intensified paddy and wheat open biomass burning during November 2016 and April 2017, respectively. The average concentrations of BC, PM2.5 and PM10 were 11.3±6.2 µg m-3, 96.7±48.9 µg m-3 and 132.3±59.1 µg m-3 respectively during the month of November 2016. On the other hand, the surface concentrations of BC, PM2.5 and PM10 were found to be 11.0±8.3 µg m-3, 45.0±35.0 µg m-3 and 114.0±96.1 µg m-3 during April 2017. A significant increase in the primary pollutant concentration was observed during both types of open agricultural burning periods. However, BC/PM2.5 ratio was almost higher by factor of two during paddy burning as compared to wheat residue burning. Source characteristics and the relative contribution of agricultural burning to PM concentrations at Lumbini are being computed based on measurements of chemical tracers in ambient aerosol samples and these results will be discussed during the conference.

TNF-α gene polymorphisms: association with disease susceptibility and response to anti-TNF-α treatment in psoriatic arthritis.

PubMed

Murdaca, Giuseppe; Gulli, Rossella; Spanò, Francesca; Lantieri, Francesca; Burlando, Martina; Parodi, Aurora; Mandich, Paola; Puppo, Francesco

2014-10-01

The tumor necrosis factor-α (TNF-α) gene has been proposed as a major candidate gene in psoriatic arthritis (PsA). TNF-α is a therapeutic target for patients responding poorly to conventional treatments. We investigated the role of single-nucleotide polymorphisms (SNPs) at positions -238, -308, and +489 of the TNF-α gene in the genetic susceptibility to PsA, in the severity of the disease, and, finally, in the response to TNF-α inhibitors (adalimumab, etanercept, or infliximab). Fifty-seven Caucasian PsA patients and 155 healthy matched controls were studied. The SNP +489 variant allele A was significantly associated with PsA susceptibility (P=0.0136) and severity of clinical (Psoriasis Area and Severity Index score, American College of Rheumatology criteria, Disease Activity Score 28, and Disability Index Health Assessment Questionnaire) and laboratory (C-reactive protein and erythrocyte sedimentation rate) parameters (P-values ranging from 0.016 to 2.908 × 10(-12)). The difference in severity was accounted for by the differences between the AA and GA genotypes with respect to the GG genotype. The SNP +489A allele shows a trend of association with the response to PsA treatment with etanercept. These findings suggest a role of the SNP +489A allele in the susceptibility and severity of PsA.

Performance of the subsurface flow constructed wetlands for pretreatment of slightly polluted source water.

PubMed

Yang, Xu; Zhang, Xueping; Wang, Jifu; Zhao, Guangying; Wang, Baojian

2014-05-01

The slightly polluted source water of Yellow River was pretreated in a horizontal subsurface flow constructed wetland (HSFCW) and a lateral subsurface flow constructed wetland (LSFCW) in the Ji'nan city Reservoir, Shandong, China. During almost one years run, the results showed that at the hydraulic loading rate of 1 m/day, the removal efficiencies of chemical oxygen demand (COD), total nitrogen (TN), ammonium nitrogen (NH4 (+)-N) and total phosphorus (TP) in the HSFCW were 48.9, 51.4, 48.7 and 48.9 %, respectively, and the corresponding removal efficiencies in the LSFCW were 50.51, 53.12, 50.44 and 50.83 %, respectively. The HSFCW and LSFCW had a similar high potential for nutrients removal and LSFCW was slightly better. According to the China standard for surface water resources (GB3838-2002), mean effluent COD can reach the Class I (≤ 15 mg/L), and NH4 (+)-N and TP and TN can reach nearly the Class I (≤ 0.015 mg/L), the Class III (≤ 0.05 mg/L) and the Class IV (≤ 1.5 mg/L), respectively. It can be concluded that the slightly polluted source water from Reservoir was pretreated well by the constructed wetland.

Mars Odyssey Observes Martian Moons

NASA Image and Video Library

2018-02-22

Phobos and Deimos, the moons of Mars, are seen by the Mars Odyssey orbiter's Thermal Emission Imaging System, or THEMIS, camera. The images were taken in visible-wavelength light. THEMIS also recorded thermal-infrared imagery in the same scan. The apparent motion is due to progression of the camera's pointing during the 17-second span of the February 15, 2018, observation, not from motion of the two moons. This was the second observation of Phobos by Mars Odyssey; the first was on September 29, 2017. Researchers have been using THEMIS to examine Mars since early 2002, but the maneuver turning the orbiter around to point the camera at Phobos was developed only recently. The distance to Phobos from Odyssey during the observation was about 3,489 miles (5,615 kilometers). The distance to Deimos from Odyssey during the observation was about 12,222 miles (19,670 kilometers). An animation is available at https://photojournal.jpl.nasa.gov/catalog/PIA22248

Aerospace Medicine and Biology: A Continuing Bibliography with Indexes. Supplement 489

NASA Technical Reports Server (NTRS)

1999-01-01

This supplemental issue of Aerospace Medicine and Biology, A Continuing Bibliography with Indexes (NASA/SP-1999-7011) lists reports, articles, and other documents recently announced in the NASA STI Database. In its subject coverage, Aerospace Medicine and Biology concentrates on the biological, physiological, psychological, and environmental effects to which humans are subjected during and following simulated or actual flight in the Earth's atmosphere or in interplanetary space. References describing similar effects on biological organisms of lower order are also included. Such related topics as sanitary problems, pharmacology, toxicology, safety and survival, life support systems, exobiology, and personnel factors receive appropriate attention. Applied research receives the most emphasis, but references to fundamental studies and theoretical principles related to experimental development also qualify for inclusion. Each entry in the publication consists of a standard bibliographic citation accompanied, in most cases, by an abstract.

Genetic variation in CXCR1 haplotypes linked to severity of Streptococcus uberis infection in an experimental challenge model.

PubMed

Siebert, Lydia; Headrick, Susan; Lewis, Mark; Gillespie, Barbara; Young, Charlie; Wojakiewicz, Leszek; Kerro-Dego, Oudessa; Prado, Maria E; Almeida, Raul; Oliver, Stephen P; Pighetti, Gina M

2017-08-01

Mastitis, an inflammation of the mammary gland, costs the dairy industry billions of dollars in lost revenues annually. The prevalence and costs associated with mastitis has made genetic selection methods a target for research. Previous research has identified amino acid changes at positions 122, 207, 245, 327, and 332 in the IL8 receptor, CXCR1, that result in three dominant amino acid haplotypes: VWHKH, VWHRR, and AWQRR. We hypothesize different haplotype combinations influence a cow's resistance, strength, and duration of response to mastitis. To test this, Holstein dairy cows (n=40) were intramammarily challenged with Streptococcus uberis within 3 d post-calving. All cows developed mastitis based on isolation of S. uberis from the challenged quarter at least twice. All cows with the VWHRR x VWHRR (n=5) and AWQRR x VWHRR (n=6) haplotype combinations required antibiotic therapy due to clinical signs of mastitis and tended (P=0.08) to be different from cows with a VWHRR x VWHKH (n=6) haplotype combination where only 33.3% required antibiotic therapy. Cows with a VWHRR homozygous haplotype combination displayed significantly higher responses to challenge indicated by elevated S. uberis counts (4340±5,521.9CFU/mL; P=0.01), mammary scores (1.1±0.18; P=0.03), milk scores (0.9±0.17; P=0.002), and SCC (1,010,832±489,993cells/mL; P=0.03). Contrastingly, AWQRR x VWHRR cows had significantly lower S. uberis counts (15.3±16.46CFU/mL; P=0.01), mammary scores (0.3±0.16; P=0.03), milk scores (0±0.15; P=0.002), and SCC (239,261±92,264.3cells/mL; P=0.03). Cows of the VWHKH x VWHRR haplotype combination displayed responses to challenge statistically comparable to other haplotype combinations, but appeared to have an earlier peak in SCC in comparison to all other haplotype combinations. Haplotype combination did not influence milk yield (P=0.6). Our results suggest using combinations of the SNPs within the CXCR1 gene gives a better indication of a cow's ability to combat S. uberis mastitis and could resolve prior studies' conflicting results focusing on individual SNP. Copyright © 2017 Elsevier B.V. All rights reserved.

Organic Metals and Semiconductors: The Chemistry of Polyacetylene, (CH)x, and Its Derivatives.

DTIC Science & Technology

1979-10-21

Park, Y.W., and Shirakawa, H.: 1978, J. Amer. .4.. Chem. Soc. 100, pp. 1013-1015. 10. Gau, S.C., Milliken, J., Pron , A., MacDiarmid, A.G., and Hee- ger...Clarke, T.C., Geiss, R.R., Kwak, J.F., and Street, G.B.: 1978, Chem. Comm., pp. 489-490. 1 17. Pron , A., MacDiarmid, A.G., and Heeger, A.J.: 1979, unpub...J., Heeger, A.J., Pron , A. and Mac- Diarmid, A.G.: 1979, Phys. Rev. B 20, pp. 223-230. 21. Clarke, T.C., Geiss, R.H., Gill, W.D., Grant, P.M

Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.

PubMed

Chen, Jun; Peng, Zhangzhe; Lu, Miaomiao; Xiong, Xuan; Chen, Zhuo; Li, Qianbin; Cheng, Zeneng; Jiang, Dejian; Tao, Lijian; Hu, Gaoyun

2018-01-15

Oxidative stress, inflammation and fibrosis can cause irreversible damage on cell structure and function of kidney and are key pathological factors in Diabetic Nephropathy (DN). Therefore, multi-target agents are urgently need for the clinical treatment of DN. Using Pirfenidone as a lead compound and based on the previous research, two novel series (5-trifluoromethyl)-2(1H)-pyridone analogs were designed and synthesized. SAR of (5-trifluoromethyl)-2(1H)-pyridone derivatives containing nitrogen heterocyclic ring have been established for in vitro potency. In addition, compound 8, a novel agent that act on multiple targets of anti-DN with IC 50 of 90μM in NIH3T3 cell lines, t 1/2 of 4.89±1.33h in male rats and LD 50 >2000mg/kg in mice, has been advanced to preclinical studies as an oral treatment for DN. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Crustal Rock Clast in Magnesian Anorthositic Breccia, Dhofar 489 and Its Excavation from a Large Basin

NASA Technical Reports Server (NTRS)

Takeda, Hiroshi; Bogard, D. D.; Yamaguchi, Akira; Ohtake, Makiko; Saiki, Kazuto

2004-01-01

We report the mineralogy and Ar-Ar age of a spinel troctolite clast with a granulitic texture found in the Dofar 489 lunar meteorite. This anothositic breccia contained magnesian mafic silicates not common in ferroan anorthosites (FAN) from the Feldspathic Highlands Terrane (FHT) of Joliff et al. The Ar-Ar ages of most FANs in the Apollo sample collection from the Procellarum KREEP Terrane (PKT) and FHT of the near-side of the Moon were reset at around 3.9 Gyr. by the basin forming event of Imbrium. From the older Ar-Ar age of Dho 489, we propose that a large basin formation other than the Imbrium basin may have mixed deep crustal rocks such as spinel troctolites with "pure" anrthosites to produce a magnesian anorthosite brecca. This model is in line with a proposal by Bussey and Spudis, who reported that inner rings of large basins display massifs of nearly pure anorthosites.

Magnesian anorthosites and a deep crustal rock from the farside crust of the moon

NASA Astrophysics Data System (ADS)

Takeda, Hiroshi; Yamaguchi, A.; Bogard, D. D.; Karouji, Y.; Ebihara, M.; Ohtake, M.; Saiki, K.; Arai, T.

2006-07-01

Among over thirty lunar meteorites recovered from the hot deserts and Antarctica, Dhofar 489 is the most depleted in thorium (0.05 ppm), FeO, and rare earth elements (REE). Dhofar 489 is a crystalline matrix anorthositic breccia and includes clasts of magnesian anorthosites and a spinel troctolite. The Mg / (Mg + Fe) mol% (Mg numbers = 75-85) of olivine and pyroxene grains in this meteorite are higher than those of the Apollo ferroan anorthosites. Such materials were not recovered by the Apollo and Luna missions. However, remote sensing data suggest that the estimated concentrations of Th and FeO are consistent with the presence of such samples on the farside of the Moon. The differentiation trend deduced from the mineralogy of the anorthositic clasts define a magnesian extension of the ferroan anorthosite (FAN) trend constructed from the Apollo samples. The presence of magnesian anorthositic clasts in Dhofar 489 still offers a possibility that the farside trend with magnesian compositions is more primitive than the FAN trend, and may require a revision of this classical differentiation trend. The Ar-Ar age of Dhofar 489 is 4.23 ± 0.034 Gyr, which is older than most Ar ages reported for highland rocks returned by Apollo. The old Ar-Ar age of impact formation of this breccia and the presence of a fragment of spinel troctolite of deep crustal origin suggest that a basin forming event on the farside excavated the deep crust and magnesian anorthosites before formation of Imbrium.

Racial Differences in Information Needs During and After Cancer Treatment: a Nationwide, Longitudinal Survey by the University of Rochester Cancer Center National Cancer Institute Community Oncology Research Program.

PubMed

Asare, Matthew; Peppone, Luke J; Roscoe, Joseph A; Kleckner, Ian R; Mustian, Karen M; Heckler, Charles E; Guido, Joseph J; Sborov, Mark; Bushunow, Peter; Onitilo, Adedayo; Kamen, Charles

2018-02-01

Before treatment, cancer patients need information about side effects and prognosis, while after treatment they need information to transition to survivorship. Research documenting these needs is limited, especially among racial and ethnic minorities. This study evaluated cancer patients' needs according to race both before and after treatment. We compared white (n = 904) to black (n = 52) patients receiving treatment at 17 National Cancer Institute Community Oncology Research Program (NCORP) sites on their cancer-related concerns and need for information before and after cancer treatment. Two-sample t test and chi-squared analyses were used to assess group differences. Compared to white patients, black patients reported significantly higher concerns about diet (44.3 vs. 25.4 %,) and exercise (40.4 vs. 19.7 %,) during the course of treatment. Compared to whites, blacks also had significantly higher concern about treatment-related issues (white vs. black mean, 25.52 vs. 31.78), self-image issues (7.03 vs. 8.60), family-related issues (10.44 vs. 12.84), and financial concerns (6.42 vs. 8.90, all p < 0.05). Blacks, compared to whites, also had significantly greater post-treatment information needs regarding follow-up tests (8.17 vs. 9.44), stress management (4.12 vs. 4.89), and handling stigma after cancer treatment (4.21 vs. 4.89) [all p < 0.05]. Pre-treatment concerns and post-treatment information needs differed by race, with black patients reporting greater information needs and concerns. In clinical practice, tailored approaches may work particularly well in addressing the needs and concerns of black patients.

Modeling and verification of process parameters for the production of tannase by Aspergillus oryzae under submerged fermentation using agro-wastes.

PubMed

Varadharajan, Venkatramanan; Vadivel, Sudhan Shanmuga; Ramaswamy, Arulvel; Sundharamurthy, Venkatesaprabhu; Chandrasekar, Priyadharshini

2017-01-01

Tannase production by Aspergillus oryzae using various agro-wastes as substrates by submerged fermentation was studied in this research. The microbe was isolated from degrading corn kernel obtained from the corn fields at Tiruchengode, India. The microbial identification was done using 18S rRNA gene analysis. The agro-wastes chosen for the study were pomegranate rind, Cassia auriculata flower, black gram husk, and tea dust. The process parameters chosen for optimization study were substrate concentration, pH, temperature, and incubation period. During one variable at a time optimization, the pomegranate rind extract produced maximum tannase activity of 138.12 IU/mL and it was chosen as the best substrate for further experiments. The quadratic model was found to be the effective model for prediction of tannase production by A. oryzae. The optimized conditions predicted by response surface methodology (RSM) with genetic algorithm (GA) were 1.996% substrate concentration, pH of 4.89, temperature of 34.91 °C, and an incubation time of 70.65 H with maximum tannase activity of 138.363 IU/mL. The confirmatory experiment under optimized conditions showed tannase activity of 139.22 IU/mL. Hence, RSM-GA pair was successfully used in this study to optimize the process parameters required for the production of tannase using pomegranate rind. © 2015 International Union of Biochemistry and Molecular Biology, Inc.

Carbon emission and sequestration of urban turfgrass systems in Hong Kong.

PubMed

Kong, Ling; Shi, Zhengjun; Chu, L M

2014-03-01

Climate change is more than just a global issue. Locally released carbon dioxide may lead to a rise in global ambient temperature and influence the surrounding climate. Urban greenery may mitigate this as they can remove carbon dioxide by storing carbon in substrates and vegetation. On the other hand, urban greenery systems which are under intense management and maintenance may contribute to the emission of carbon dioxide or other greenhouse gases. The impact of urban greenery on carbon balance in major metropolitan areas thus remains controversial. We investigated the carbon footprints of urban turf operation and maintenance by conducting a research questionnaire on different Hong Kong turfs in 2012, and showed that turf maintenance contributed 0.17 to 0.63 kg Ce m(-2)y(-1) to carbon emissions. We also determined the carbon storage of turfs at 0.05 to 0.21 kg C m(-2) for aboveground grass biomass and 1.26 to 4.89 kg C m(-2) for soils (to 15 cm depth). We estimated that the carbon sink capacity of turfs could be offset by carbon emissions in 5-24 years under current management patterns, shifting from carbon sink to carbon source. Our study suggested that maintenance management played a key role in the carbon budget and footprint of urban greeneries. The environmental impact of turfgrass systems can be optimized by shifting away from empirically designed maintenance schedules towards rational ones based on carbon sink and emission principles. Copyright © 2014 Elsevier B.V. All rights reserved.

Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin

PubMed Central

Meczes, E L; Pearson, A D J; Austin, C A; Tilby, M J

2002-01-01

The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin. British Journal of Cancer (2002) 86, 485–489. DOI: 10.1038/sj/bjc/6600060 www.bjcancer.com © 2002 The Cancer Research Campaign PMID:11875719

First axion bounds from a pulsating helium-rich white dwarf star

DOE Office of Scientific and Technical Information (OSTI.GOV)

Battich, T.; Córsico, A.H.; Althaus, L.G.

The Peccei-Quinn mechanism proposed to solve the CP problem of Quantum Chromodynamics has as consequence the existence of axions, hypothetical weakly interacting particles whose mass is constrained to be on the sub-eV range. If these particles exist and interact with electrons, they would be emitted from the dense interior of white dwarfs, becoming an important energy sink for the star. Due to their well known physics, white dwarfs are good laboratories to study the properties of fundamental particles such as the axions. We study the general effect of axion emission on the evolution of helium-rich white dwarfs and on theirmore » pulsational properties. To this aim, we calculate evolutionary helium-rich white dwarf models with axion emission, and assess the pulsational properties of this models. Our results indicate that the rates of change of pulsation periods are significantly affected by the existence of axions. We are able for the first time to independently constrain the mass of the axion from the study of pulsating helium-rich white dwarfs. To do this, we use an estimation of the rate of change of period of the pulsating white dwarf PG 1351+489 corresponding to the dominant pulsation period. From an asteroseismological model of PG 1351+489 we obtain g {sub ae} < 3.3 × 10{sup -13} for the axion-electron coupling constant, or m {sub a} cos{sup 2}β ∼< 11.5 meV for the axion mass. This constraint is relaxed to g {sub ae} < 5.5 × 10{sup -13} ( m {sub a} cos{sup 2}β ∼< 19.5 meV), when no detailed asteroseismological model is adopted for the comparison with observations.« less

Inactivation of Gating Currents of L-Type Calcium Channels

PubMed Central

Shirokov, Roman; Ferreira, Gonzalo; Yi, Jianxun; Ríos, Eduardo

1998-01-01

In studies of gating currents of rabbit cardiac Ca channels expressed as α1C/β2a or α1C/β2a/α2δ subunit combinations in tsA201 cells, we found that long-lasting depolarization shifted the distribution of mobile charge to very negative potentials. The phenomenon has been termed charge interconversion in native skeletal muscle (Brum, G., and E. Ríos. 1987. J. Physiol. (Camb.). 387:489–517) and cardiac Ca channels (Shirokov, R., R. Levis, N. Shirokova, and E. Ríos. 1992. J. Gen. Physiol. 99:863–895). Charge 1 (voltage of half-maximal transfer, V1/2 ≃ 0 mV) gates noninactivated channels, while charge 2 (V1/2 ≃ −90 mV) is generated in inactivated channels. In α1C/β2a cells, the available charge 1 decreased upon inactivating depolarization with a time constant τ ≃ 8, while the available charge 2 decreased upon recovery from inactivation (at −200 mV) with τ ≃ 0.3 s. These processes therefore are much slower than charge movement, which takes <50 ms. This separation between the time scale of measurable charge movement and that of changes in their availability, which was even wider in the presence of α2δ, implies that charges 1 and 2 originate from separate channel modes. Because clear modal separation characterizes slow (C-type) inactivation of Na and K channels, this observation establishes the nature of voltage-dependent inactivation of L-type Ca channels as slow or C-type. The presence of the α2δ subunit did not change the V1/2 of charge 2, but sped up the reduction of charge 1 upon inactivation at 40 mV (to τ ≃ 2 s), while slowing the reduction of charge 2 upon recovery (τ ≃ 2 s). The observations were well simulated with a model that describes activation as continuous electrodiffusion (Levitt, D. 1989. Biophys. J. 55:489–498) and inactivation as discrete modal change. The effects of α2δ are reproduced assuming that the subunit lowers the free energy of the inactivated mode. PMID:9607938

Perfectionistic concerns predict increases in adolescents' anxiety symptoms: a three-wave longitudinal study.

PubMed

Damian, Lavinia E; Negru-Subtirica, Oana; Stoeber, Joachim; Băban, Adriana

2017-09-01

Although perfectionism has been proposed to be a risk factor for the development of anxiety, research on perfectionism and anxiety symptoms in adolescents is scarce and inconclusive. The aim of the present study was to investigate whether the two higher-order dimensions of perfectionism - perfectionistic strivings and perfectionistic concerns - predict the development and maintenance of anxiety symptoms. An additional aim of the present study was to examine potential reciprocal effects of anxiety symptoms predicting increases in perfectionism. The study used a longitudinal design with three waves spaced 4-5 months apart. A non-clinical sample of 489 adolescents aged 12-19 years completed a paper-and-pencil questionnaire. As expected, results showed a positive effect from perfectionistic concerns to anxiety symptoms, but the effect was restricted to middle-to-late adolescents (16-19 years old): Perfectionistic concerns predicted longitudinal increases in adolescents' anxiety symptoms, whereas perfectionistic strivings did not. Furthermore, anxiety symptoms did not predict increases in perfectionism. Implications for the understanding of the relationship between perfectionism and anxiety symptoms are discussed.

Trapping para-Quinone Methide Intermediates with Ferrocene: Synthesis and Preliminary Biological Evaluation of New Phenol-Ferrocene Conjugates.

PubMed

González-Pelayo, Silvia; López, Enol; Borge, Javier; de-Los-Santos-Álvarez, Noemí; López, Luis A

2018-06-01

The reaction of para -hydroxybenzyl alcohols with ferrocene in the presence of a catalytic amount of InCl₃ provided ferrocenyl phenol derivatives, an interesting class of organometallic compounds with potential applications in medicinal chemistry. This transformation exhibited a reasonable substrate scope delivering the desired products in synthetically useful yields. Evidence of involvement of a para -quinone methide intermediate in this coupling process was also provided. Preliminary biological evaluation demonstrated that some of the ferrocene derivatives available by this methodology exhibit significant cytotoxicity against several cancer cell lines with IC 50 values within the range of 1.07⁻4.89 μM.

Effect of kenaf short fiber loading on mechanical properties of biocomposites

NASA Astrophysics Data System (ADS)

Andilolo, J.; Nikmatin, S.; Nugroho, N.; Alatas, H.; Wismogroho, A. S.

2017-05-01

The research of biocomposite product with kenaf (Hibiscus cannabinus) short fiber as a filler and Acrylonitrile Butadiene Styrene (ABS) as the matrix had been done to understand the mechanical properties of this material. Kenaf short fiber was obtained from mechanical sieving after doing the mechanical milling. TAPPI method has been done to determine the chemical properties. In order to form a granular biocomposite a single screw extruder was performed with a variation of particle loading 10 and 15%. The original of acrylonitrile butadiene styrene (ABS) has been used as matrix. The fabrication of speciment had been done by molding injection process. Mechanical properties test was done by ASTM standarization. The results showed the density of the fibers of 1.008 g/cm3 with a fiber length of 897.07 µm and a diameter of 66.38 µm. Tensile strength of kenaf short fiber loading 10 and 15% was 23.522 ± 8.36 MPa and 20.739 ± 6.79 MPa, respectively. The tensile properties showed a decreasing trend as the fiber loading was increased. The values of impact strength were 68.657 ± 4.89 kJ m-2 and 82.090 ± 5.56 kJ m-2, respectively and the hardness values were 96.60 ± 6.03 HR and 105.20 ± 13.17 HR, respectively. Kenaf fiber can be a good reinforcement candidate for high performance polymer bio-composites.

Ovarian response to recombinant human follicle-stimulating hormone in luteinizing hormone-depleted women: examination of the two cell, two gonadotropin theory.

PubMed

Ben-Chetrit, A; Gotlieb, L; Wong, P Y; Casper, R F

1996-04-01

To evaluate the relative contribution of FSH to ovarian estrogen production. Nonrandomized, prospective study. University of Toronto teaching hospital reproductive biology unit. Five women who had been treated with depot GnRH agonist with hormonal add-back for 4 to 48 months and who were confirmed to be gonadotropin depleted by both bioassay and RIA. Subjects received 75 IU SC recombinant human FSH daily for 7 days followed by 150 IU daily for 7 days and 225 IU daily for the third week. Serum steroid determination and vaginal sonography for follicle size and endometrial thickness were performed serially and follicular fluid hormone levels were measured in two subjects. Bioactive LH and FSH activity were less than the detection limit of the assay (0.1 mIU/mL; conversion factor to SI units, 1.00 for LH and FSH) before recombinant FSH treatment in all five women. In all subjects, at least one preovulatory follicle developed by the end of two to three weeks. Endometrial thickness increased to between 7 and 9 mm in four women. Mean serum E2 in the five subjects increased from 17 pg/mL (range: 5 to 33 pg/mL; conversion factor to SI unit, 3.671) at baseline to 230 pg/mL (range: 37 to 489 pg/mL) at the end of the study. Follicular fluid E2 concentrations ranged from 44,296 to 69,367 pg/mL in the four follicles aspirated. Our results indicate that LH is not necessary for ovarian E2 production. We speculate that the granulosa cells, in the absence of detectable LH bioactivity, can use circulating adrenal androgens or constitutive or FSH-stimulated thecal androgens, to produce intrafollicular E2.

Efficient multiparty quantum-secret-sharing schemes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao Li; Deng Fuguo; Key Laboratory for Quantum Information and Measurements, MOE, Beijing 100084

In this work, we generalize the quantum-secret-sharing scheme of Hillery, Buzek, and Berthiaume [Phys. Rev. A 59, 1829 (1999)] into arbitrary multiparties. Explicit expressions for the shared secret bit is given. It is shown that in the Hillery-Buzek-Berthiaume quantum-secret-sharing scheme the secret information is shared in the parity of binary strings formed by the measured outcomes of the participants. In addition, we have increased the efficiency of the quantum-secret-sharing scheme by generalizing two techniques from quantum key distribution. The favored-measuring-basis quantum-secret-sharing scheme is developed from the Lo-Chau-Ardehali technique [H. K. Lo, H. F. Chau, and M. Ardehali, e-print quant-ph/0011056] wheremore » all the participants choose their measuring-basis asymmetrically, and the measuring-basis-encrypted quantum-secret-sharing scheme is developed from the Hwang-Koh-Han technique [W. Y. Hwang, I. G. Koh, and Y. D. Han, Phys. Lett. A 244, 489 (1998)] where all participants choose their measuring basis according to a control key. Both schemes are asymptotically 100% in efficiency, hence nearly all the Greenberger-Horne-Zeilinger states in a quantum-secret-sharing process are used to generate shared secret information.« less

How is the instrumental color of meat measured?

PubMed

Tapp, W N; Yancey, J W S; Apple, J K

2011-09-01

Peer-reviewed journal articles (n=1068) were used to gather instrumental color measurement information in meat science research. The majority of articles, published in 10 peer-reviewed journals, originated from European countries (44.8%) and North America (38.5%). The predominant species was pork (44.2%), and most researchers used Minolta (60.0%) over Hunter (31.6%) colorimeters. Much of the research was done using illuminant D65 (32.3%); nevertheless, almost half (48.9%) of the articles did not report the illuminant. Moreover, a majority of the articles did not report aperture size (73.6%) or the number of readings per sample (52.4%). Many factors influence meat color, and a considerable proportion of the peer-reviewed, published research articles failed to include information necessary to replicate and/or interpret instrumental color results; therefore, a standardized set of minimum reportable parameters for meat color evaluation should be identified. Copyright © 2011 Elsevier Ltd. All rights reserved.

Yellow (577 nm) micropulse laser versus half-dose verteporfin photodynamic therapy in eyes with chronic central serous chorioretinopathy: results of the Pan-American Collaborative Retina Study (PACORES) Group.

PubMed

Roca, Jose A; Wu, Lihteh; Fromow-Guerra, Jans; Rodríguez, Francisco J; Berrocal, Maria H; Rojas, Sergio; Lima, Luiz H; Gallego-Pinazo, Roberto; Chhablani, Jay; Arevalo, J Fernando; Lozano-Rechy, David; Serrano, Martin

2018-02-08

To compare the functional and anatomical outcomes of eyes with chronic central serous chorioretinopathy treated with yellow micropulse (MP) laser versus half-dose verteporfin photodynamic therapy (PDT). This is a multicentre, retrospective comparative study of 92 eyes treated with yellow MP laser (duty cycle of 5%, zero spacing between spots, spot size varied from 100 to 200 µm, power varied from 320 to 660 mW, and the pulse burst duration was 200 ms) and 67 eyes treated with PDT (half-dose verteporfin (3 mg/m 2 ) infused over 10 min), followed by laser activation for 83 s. Spot sizes varied from 400 to 2000 µm. In the MP group, at 12 months of follow-up, the mean best corrected visual acuity (BCVA) improved from the logarithm of the minimum angle of resolution (logMAR) of 0.41±0.27 at baseline to 0.21±0.26 (P<0.0001), 48.9% (45/92) of eyes had an improvement of ≥3 lines of BCVA from baseline, 48.9% (45/92) of eyes remained within 2 lines of baseline BCVA, and only 2.2% (2/92) of eyes lost ≥3 lines of BCVA from baseline. In the PDT group, at 12 months of follow-up, the mean BCVA changed from logMAR of 0.50±0.34 at baseline to 0.47±0.34 (P=0.89), 19% (13/67) of eyes had an improvement of ≥3 lines of BCVA from baseline, 73% (49/67) of eyes remained within 2 lines of baseline BCVA, and 7% (5/67) of eyes lost ≥3 lines of BCVA from baseline. There were no adverse events attributable to the yellow MP laser treatment. One eye in the PDT group developed choroidal neovascularisation, which was treated with three intravitreal bevacizumab injections. Both PDT and MP are effective in restoring the macular anatomy. In places where PDT is not available, yellow MP laser may be an adequate treatment alternative. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Upper Albian and Cenomanian (Cretaceous) ammonites from the Debarsu Formation (Yazd Block, Central Iran)

NASA Astrophysics Data System (ADS)

Wilmsen, Markus; Storm, Marisa; Fürsich, Franz Theodor; Majidifard, Mahmoud Reza

2013-12-01

Wilmsen, M., Storm, M., Fürsich, F.T. and Majidifard, M.R. 2013. Upper Albian and Cenomanian (Cretaceous) ammonites from the Debarsu Formation (Yazd Block, Central Iran). Acta Geologica Polonica, 63 (4), 489-513. Warszawa. New ammonite faunas consisting of 13 taxa provide the first reliable biostratigraphic dating of the Debarsu Formation of the Yazd Block, west-central Iran, indicating several levels in the Upper Albian and Lower Cenomanian, while a foraminiferal assemblage places the top of the Formation in the Middle Turonian. Among the identified ammonite taxa, Acompsoceras renevieri (Sharpe, 1857) is recorded from Iran for the first time. The upper part of the lower Upper Albian is proved by the occurrences of mortoniceratines of the Mortoniceras (M.) inflatum Zone in the lowermost part of the Debarsu Formation. For the upper Upper Albian (traditional Stoliczkaia dispar Zone), the M. (Subschloenbachia ) rostratum and M. (S.) perinflatum zones are proved by their index taxa. However, there is no evidence of the terminal Arrhaphoceras (Praeschloenbachia) briacensis Zone. The upper part of the lower Lower Cenomanian Mantelliceras mantelli Zone (M. saxbii Subzone) is proved by M. saxbii and M. cf. mantelli. Below, there is an ammonite- barren interval of ca. 100 m in thickness between M. (S.) perinflatum zonal strata and the M. saxbii Subzone. The upper Lower Cenomanian is documented by the presence of typically M. dixoni zonal ammonites such as Acompsoceras renevieri. Upper Cenomanian and Turonian ammonites have not been found in the upper part of the Debarsu Formation, but micro-biostratigraphic evidence (planktonic foraminifers) from the uppermost part of the formation indicate that the formation ranges into the Turonian. For the development of the major tectonic unconformity at the base of the overlying Haftoman Formation (which yielded Lower Coniacian inoceramids near its base), only 2-3 myr remain, stressing the geodynamic activity of Central Iran during mid-Cretaceous times.

Microbiological Safety of Commercial Prime Rib Preparation Methods: Thermal Inactivation of Salmonella in Mechanically Tenderized Rib Eye.

PubMed

Calle, Alexandra; Porto-Fett, Anna C S; Shoyer, Bradley A; Luchansky, John B; Thippareddi, Harshavardhan

2015-12-01

Boneless beef rib eye roasts were surface inoculated on the fat side with ca. 5.7 log CFU/g of a five-strain cocktail of Salmonella for subsequent searing, cooking, and warm holding using preparation methods practiced by restaurants surveyed in a medium-size Midwestern city. A portion of the inoculated roasts was then passed once through a mechanical blade tenderizer. For both intact and nonintact roasts, searing for 15 min at 260°C resulted in reductions in Salmonella populations of ca. 0.3 to 1.3 log CFU/g. For intact (nontenderized) rib eye roasts, cooking to internal temperatures of 37.8 or 48.9°C resulted in additional reductions of ca. 3.4 log CFU/g. For tenderized (nonintact) rib eye roasts, cooking to internal temperatures of 37.8 or 48.9°C resulted in additional reductions of ca. 3.1 or 3.4 log CFU/g, respectively. Pathogen populations remained relatively unchanged for intact roasts cooked to 37.8 or 48.9°C and for nonintact roasts cooked to 48.9°C when held at 60.0°C for up to 8 h. In contrast, pathogen populations increased ca. 2.0 log CFU/g in nonintact rib eye cooked to 37.8°C when held at 60.0°C for 8 h. Thus, cooking at low temperatures and extended holding at relatively low temperatures as evaluated herein may pose a food safety risk to consumers in terms of inadequate lethality and/or subsequent outgrowth of Salmonella, especially if nonintact rib eye is used in the preparation of prime rib, if on occasion appreciable populations of Salmonella are present in or on the meat, and/or if the meat is not cooked adequately throughout.

Effect of Blade Curvature Angle of Savonius Horizontal Axis Water Turbine to the Power Generation

NASA Astrophysics Data System (ADS)

Apha Sanditya, Taufan; Prasetyo, Ari; Kristiawan, Budi; Hadi, Syamsul

2018-03-01

The water energy is one of potential alternative in creating power generation specifically for the picohydro energy. Savonius is a kind of wind turbine which now proposed to be operated utilizing the energy from low fluid flow. Researches about the utilization of Savonius turbine have been developed in the horizontal water pipelines and wave. The testing experimental on the Savonius Horizontal Axis Water Turbine (HAWT) by observing the effect of the blade curvature angle (ψ) of 110°, 120°, 130°, and 140° at the debit of 176.4 lpm, 345 lpm, 489.6 lpm, and 714 lpm in order to know the power output was already conducted. The optimal result in every debit variation was obtained in the blade curvature angle of 120°. In the maximum debit of 714 lpm with blade curvature angle of 120° the power output is 39.15 Watt with the coefficient power (Cp) of 0.23 and tip speed ratio (TSR) of 1.075.

Vital Recorder-a free research tool for automatic recording of high-resolution time-synchronised physiological data from multiple anaesthesia devices.

PubMed

Lee, Hyung-Chul; Jung, Chul-Woo

2018-01-24

The current anaesthesia information management system (AIMS) has limited capability for the acquisition of high-quality vital signs data. We have developed a Vital Recorder program to overcome the disadvantages of AIMS and to support research. Physiological data of surgical patients were collected from 10 operating rooms using the Vital Recorder. The basic equipment used were a patient monitor, the anaesthesia machine, and the bispectral index (BIS) monitor. Infusion pumps, cardiac output monitors, regional oximeter, and rapid infusion device were added as required. The automatic recording option was used exclusively and the status of recording was frequently checked through web monitoring. Automatic recording was successful in 98.5% (4,272/4,335) cases during eight months of operation. The total recorded time was 13,489 h (3.2 ± 1.9 h/case). The Vital Recorder's automatic recording and remote monitoring capabilities enabled us to record physiological big data with minimal effort. The Vital Recorder also provided time-synchronised data captured from a variety of devices to facilitate an integrated analysis of vital signs data. The free distribution of the Vital Recorder is expected to improve data access for researchers attempting physiological data studies and to eliminate inequalities in research opportunities due to differences in data collection capabilities.

Study on the Secondary Electron Yield γ of Insulator for PDP Cathode

NASA Astrophysics Data System (ADS)

Motoyama, Y.; Ushirozawa, M.; Matsuzaki, H.; Takano, Y.; Seki, M.

1999-10-01

The secondary electron yield γ of the Plasma Display Panel (PDP) cathode is an important research object because it is closely related to the discharge voltages etc. For metal cathodes, we made a comprehensive examination^1 of γ for all rare gas ions and metastables according to Hagstrum's theory.^2 For γ of MgO, which is the useful insulator cathode, Aboelfotoh et al.^3 calculated the values for Ne and Ar ions supposing a monochrome PDP. However, the values of γ for other rare gas ions and their metastables necessary for a full color PDP have not yet been calculated. These values are calculated in the present study after them. The results are as follows: For ions, He:0.481 and Kr,Xe:0, assuming that there are no impurity levels in MgO; For metastables, He:0.491, Ne:0.489, Ar:0.428, Kr:0.381, and Xe:0.214. These results should serve as useful parameters in discharge simulation for the PDP. ^1H. Matsuzaki: Trans. IEE Jpn., 111-A, 971 (1991). ^2H.D. Hagstrum: Phys. Rev., 96, 336 (1954), ibid., 122, 83 (1961). ^3M.O. Aboelfotoh and J.A. Lorenzen: J. Appl. Phys., 48, 4754 (1977).

Developing and validating a sham cupping device.

PubMed

Lee, Myeong Soo; Kim, Jong-In; Kong, Jae Cheol; Lee, Dong-Hyo; Shin, Byung-Cheul

2010-12-01

The aims of this study were to develop a sham cupping device and to validate its use as a placebo control for healthy volunteers. A sham cupping device was developed by establishing a small hole to reduce the negative pressure after suction such that inner pressure could not be maintained in the cup. We enrolled 34 healthy participants to evaluate the validity of the sham cupping device as a placebo control. The participants were informed that they would receive either real or sham cupping and were asked which treatment they thought they had received. Other sensations and adverse events related to cupping therapy were investigated. 17 patients received real cupping therapy and 17 received sham cupping. The two groups felt similar sensations. There was a tendency for subjects to feel that real cupping created a stronger sensation than sham cupping (48.9±21.4 vs 33.3±20.3 on a 100mm visual analogue scale). There were only mild to moderate adverse events observed in both groups. We developed a new sham cupping device that seems to provide a credible control for real cupping therapy by producing little or no negative pressure. This conclusion was supported by a pilot study, but more rigorous research is warranted regarding the use of this device.

Validation of cooking times and temperatures for thermal inactivation of Yersinia pestis strains KIM5 and CDC-A1122 in irradiated ground beef.

PubMed

Porto-Fett, Anna C S; Juneja, Vijay K; Tamplin, Mark L; Luchansky, John B

2009-03-01

Irradiated ground beef samples (ca. 3-g portions with ca. 25% fat) inoculated with Yersina pestis strain KIM5 (ca. 6.7 log CFU/g) were heated in a circulating water bath stabilized at 48.9, 50, 52.5, 55, 57.5, or 60 degrees C (120, 122, 126.5, 131, 135.5, and 140 degrees F, respectively). Average D-values were 192.17, 34.38, 17.11, 3.87, 1.32, and 0.56 min, respectively, with a corresponding z-value of 4.67 degrees C (8.41 degrees F). In related experiments, irradiated ground beef patties (ca. 95 g per patty with ca. 25% fat) were inoculated with Y. pestis strains KIMS or CDC-A1122 (ca. 6.0 log CFU/g) and cooked on an open-flame gas grill or on a clam-shell type electric grill to internal target temperatures of 48.9, 60, and 71.1 degrees C (120, 140, and 160 degrees F, respectively). For patties cooked on the gas grill, strain KIM5 populations decreased from ca. 6.24 to 4.32, 3.51, and < or = 0.7 log CFU/g at 48.9, 60, and 71.1 degrees C, respectively, and strain CDC-A1122 populations decreased to 3.46 log CFU/g at 48.9 degrees C and to < or = 0.7 log CFU/g at both 60 and 71.1 degrees C. For patties cooked on the clam-shell grill, strain KIM5 populations decreased from ca. 5.96 to 2.53 log CFU/g at 48.9 degrees C and to < or = 0.7 log CFU/g at 60 or 71.1 degrees C, and strain CDC-A1122 populations decreased from ca. 5.98 to < or = 0.7 log CFU/g at all three cooking temperatures. These data confirm that cooking ground beef on an open-flame gas grill or on a clam-shell type electric grill to the temperatures and times recommended by the U.S. Department of Agriculture and the U.S. Food and Drug Administration Food Code, appreciably lessens the likelihood, severity, and/or magnitude of consumer illness if the ground beef were purposefully contaminated even with relatively high levels of Y. pestis.

Die Liberalisierung de Telekommunikationsbranche in Deutschland( The Liberalization of the Telecommunication-Industry in Germany)

DTIC Science & Technology

2004-03-01

however, the German telecommunication-industry has, like the telecommunication in other European countries, had dramatic development experiences...liberalization-measures are described and are analyzed their effects on the different markets. While the competition in the markets for fine - and foreign...ýonstige 0.182 0.267 . 0.566 1.093 2.108 6umme 0.161 1.235 2.740 3.489 4.589 4.872 17,09 Anmerk-ung: Negat ive Werte stellen eine negative Verlndemng der und

Autonomy and structure can enhance motivation of volunteers in sport organizations.

PubMed

Hsu, Wei Ting; Wu, Kou Hsien; Wang, Yi Ching; Hsiao, Chia Huei; Wu, Hui Chin

2013-12-01

The goal was better understanding of the motivational factors of volunteers in non-profit sport organizations. The roles of two factors provided by supervisors to their subordinates were examined: autonomy support, i.e., the encouragement of self-initiation and emphasis on choice rather than control, and structure, i.e., the introduction of order, definite procedures, and rules. 489 sport volunteers (289 men, 200 women; M age = 31.2 yr., SD = 7.4) were administered questionnaires assessing their perceived autonomy support, structure, and motivation. Regression analysis indicated that perceived autonomy support predicted motivation. Structure also mediated the effect of perceived autonomy support on motivation. Supervisors of sport organizations should provide adequate structure for their volunteers.

High Above Jupiter's Clouds

NASA Image and Video Library

2018-01-04

NASA's Juno spacecraft was a little more than one Earth diameter from Jupiter when it captured this mind-bending, color-enhanced view of the planet's tumultuous atmosphere. Jupiter completely fills the image, with only a hint of the terminator (where daylight fades to night) in the upper right corner, and no visible limb (the curved edge of the planet). Juno took this image of colorful, turbulent clouds in Jupiter's northern hemisphere on Dec. 16, 2017 at 9:43 a.m. PST (12:43 p.m. EST) from 8,292 miles (13,345 kilometers) above the tops of Jupiter's clouds, at a latitude of 48.9 degrees. The spatial scale in this image is 5.8 miles/pixel (9.3 kilometers/pixel).. Citizen scientists Gerald Eichstädt and Seán Doran processed this image using data from the JunoCam imager. https://photojournal.jpl.nasa.gov/catalog/PIA21973

The Influence of Physical Qualities on Activity Profiles of Female Australian Football Match Play.

PubMed

Black, Georgia M; Gabbett, Tim J; Johnston, Rich D; Cole, Michael H; Naughton, Geraldine; Dawson, Brian

2018-04-01

The transition of female Australian football (AF) players from amateur to semielite competitions has the potential for athletes to be underprepared for match play. To gain an understanding of the match demands of female football, the aims of this study were to highlight the physical qualities that discriminate selected and nonselected female AF players, investigate activity profiles of female AF players, and gain an understanding of the influence of physical qualities on performance in female AF Methods: Twenty-two female AF state academy players (mean [SD]: age = 23.2 [4.5] y) and 27 nonselected players (mean [SD]: age = 23.4 [4.9] y) completed a Yo-Yo intermittent recovery test level 1, countermovement jump, and 30-m sprint tests were completed prior to the competitive season. During 14 matches, players wore global positioning system units to describe the running demands of match play. Selected players were faster over 30 m (ES = 0.57; P = .04) and covered greater distances on the Yo-Yo IR1 (ES = 1.09; P < .001). Selected midfielders spent greater time on the field and covered greater total distances (ES = 0.73-0.85; P < .01). Players faster over 5 m (r = -.612) and 30 m (r = -.807) and who performed better on the Yo-Yo IR1 (r = .489) covered greater high-speed distances during match play. An emphasis should be placed on the development of physical fitness in this playing group to ensure optimal preparation for the national competition.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, J. C.; Bonoli, P. T.; Schmidt, A. E.

Lower hybrid (LH) waves ({omega}{sub ci}<<{omega}<<{omega}{sub ce}, where {omega}{sub i,e}{identical_to}Z{sub i,e}eB/m{sub i,e}c) have the attractive property of damping strongly via electron Landau resonance on relatively fast tail electrons and consequently are well-suited to driving current. Established modeling techniques use Wentzel-Kramers-Brillouin (WKB) expansions with self-consistent non-Maxwellian distributions. Higher order WKB expansions have shown some effects on the parallel wave number evolution and consequently on the damping due to diffraction [G. Pereverzev, Nucl. Fusion 32, 1091 (1991)]. A massively parallel version of the TORIC full wave electromagnetic field solver valid in the LH range of frequencies has been developed [J. C. Wrightmore » et al., Comm. Comp. Phys. 4, 545 (2008)] and coupled to an electron Fokker-Planck solver CQL3D[R. W. Harvey and M. G. McCoy, in Proceedings of the IAEA Technical Committee Meeting, Montreal, 1992 (IAEA Institute of Physics Publishing, Vienna, 1993), USDOC/NTIS Document No. DE93002962, pp. 489-526] in order to self-consistently evolve nonthermal electron distributions characteristic of LH current drive (LHCD) experiments in devices such as Alcator C-Mod and ITER (B{sub 0}{approx_equal}5 T, n{sub e0}{approx_equal}1x10{sup 20} m{sup -3}). These simulations represent the first ever self-consistent simulations of LHCD utilizing both a full wave and Fokker-Planck calculation in toroidal geometry.« less

Battery Pack Life Estimation through Cell Degradation Data and Pack Thermal Modeling for BAS+ Li-Ion Batteries. Cooperative Research and Development Final Report, CRADA Number CRD-12-489

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Kandler

Battery Life estimation is one of the key inputs required for Hybrid applications for all GM Hybrid/EV/EREV/PHEV programs. For each Hybrid vehicle program, GM has instituted multi-parameter Design of Experiments generating test data at Cell level and also Pack level on a reduced basis. Based on experience, generating test data on a pack level is found to be very expensive, resource intensive and sometimes less reliable. The proposed collaborative project will focus on a methodology to estimate Battery life based on cell degradation data combined with pack thermal modeling. NREL has previously developed cell-level battery aging models and pack-level thermal/electricalmore » network models, though these models are currently not integrated. When coupled together, the models are expected to describe pack-level thermal and aging response of individual cells. GM and NREL will use data collected for GM's Bas+ battery system for evaluation of the proposed methodology and assess to what degree these models can replace pack-level aging experiments in the future.« less

Differences in research funding for women scientists: a systematic comparison of UK investments in global infectious disease research during 1997-2010.

PubMed

Head, Michael G; Fitchett, Joseph R; Cooke, Mary K; Wurie, Fatima B; Atun, Rifat

2013-12-09

There has not previously been a systematic comparison of awards for research funding in infectious diseases by sex. We investigated funding awards to UK institutions for all infectious disease research from 1997 to 2010, across disease categories and along the research and development continuum. Systematic comparison. Data were obtained from several sources for awards from the period 1997 to 2010 and each study assigned to-disease categories; type of science (preclinical, phases I-III trials, product development, implementation research); categories of funding organisation. Fold differences and statistical analysis were used to compare total investment, study numbers, mean grant and median grant between men and women. 6052 studies were included in the final analysis, comprising 4357 grants (72%) awarded to men and 1695 grants (28%) awarded to women, totalling £2.274 billion. Of this, men received £1.786 billion (78.5%) and women £488 million (21.5%). The median value of award was greater for men (£179 389; IQR £59 146-£371 977) than women (£125 556; IQR £30 982-£261 834). Awards were greater for male principal investigators (PIs) across all infectious disease systems, excepting neurological infections and sexually transmitted infections. The proportion of total funding awarded to women ranged from 14.3% in 1998 to 26.8% in 2009 (mean 21.4%), and was lowest for preclinical research at 18.2% (£285.5 million of £1.573 billion) and highest for operational research at 30.9% (£151.4 million of £489.7 million). There are consistent differences in funding received by men and women PIs: women have fewer funded studies and receive less funding in absolute and in relative terms; the median funding awarded to women is lower across most infectious disease areas, by funder, and type of science. These differences remain broadly unchanged over the 14-year study period.

Hazard Response Modeling Uncertainty (A Quantitative Method). Volume 2. Evaluation of Commonly Used Hazardous Gas Dispersion Models

DTIC Science & Technology

1993-03-01

Naval Weapons Center (NWC) at China Lake, California. Sponsored by the U.S. Dept. of Energy and the Gas Research Institute, the trials consisted of...are about an order of magnitude greater. 3. Hanford Kr 8 5 The results from 13 dispersion trials conducted at the Atomic Energy Commission’s Hanford...1.000 HC5 200 15.44 0.0155 0.996 800 1.274 0.00127 1.003 H12 200 1583 2.489 0.636 800 87.85 0.0995 0.883 H13 200 430.5 0.5049 0.853 800 14.61 0.01526

Biobleaching of industrial important dyes with peroxidase partially purified from garlic.

PubMed

Osuji, Akudo Chigozirim; Eze, Sabinus Oscar O; Osayi, Emmanuel Emeka; Chilaka, Ferdinand Chiemeka

2014-01-01

An acidic peroxidase was extracted from garlic (Allium sativum) and was partially purified threefold by ammonium sulphate precipitation, dialysis, and gel filtration chromatography using sephadex G-200. The specific activity of the enzyme increased from 4.89 U/mg after ammonium sulphate precipitation to 25.26 U/mg after gel filtration chromatography. The optimum temperature and pH of the enzyme were 50°C and 5.0, respectively. The Km and V max for H2O2 and o-dianisidine were 0.026 mM and 0.8 U/min, and 25 mM and 0.75 U/min, respectively. Peroxidase from garlic was effective in decolourizing Vat Yellow 2, Vat Orange 11, and Vat Black 27 better than Vat Green 9 dye. For all the parameters monitored, the decolourization was more effective at a pH range, temperature, H2O2 concentration, and enzyme concentration of 4.5-5.0, 50°C, 0.6 mM, and 0.20 U/mL, respectively. The observed properties of the enzyme together with its low cost of extraction (from local sources) show the potential of this enzyme for practical application in industrial wastewater treatment especially with hydrogen peroxide. These Vat dyes also exhibited potentials of acting as peroxidase inhibitors at alkaline pH range.

PKS 2005-489 at VHE: four years of monitoring with HESS and simultaneous multi-wavelength observations

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Barres de Almeida, U.; Bazer-Bachi, A. R.; Becherini, Y.; Behera, B.; Benbow, W.; Bernlöhr, K.; Bochow, A.; Boisson, C.; Bolmont, J.; Borrel, V.; Brucker, J.; Brun, F.; Brun, P.; Bühler, R.; Bulik, T.; Büsching, I.; Boutelier, T.; Chadwick, P. M.; Charbonnier, A.; Chaves, R. C. G.; Cheesebrough, A.; Chounet, L.-M.; Clapson, A. C.; Coignet, G.; Costamante, L.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; O'C. Drury, L.; Dubois, F.; Dubus, G.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Farnier, C.; Fegan, S.; Feinstein, F.; Fiasson, A.; Förster, A.; Fontaine, G.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Gérard, L.; Gerbig, D.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Goret, P.; Göring, D.; Hauser, M.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hoffmann, A.; Hofmann, W.; Hofverberg, P.; Holleran, M.; Hoppe, S.; Horns, D.; Jacholkowska, A.; de Jager, O. C.; Jahn, C.; Jung, I.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Kerschhaggl, M.; Khangulyan, D.; Khélifi, B.; Keogh, D.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Lamanna, G.; Lenain, J.-P.; Lohse, T.; Marandon, V.; Martineau-Huynh, O.; Marcowith, A.; Masbou, J.; Maurin, D.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Moderski, R.; Moulin, E.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nekrassov, D.; Nicholas, B.; Niemiec, J.; Nolan, S. J.; Ohm, S.; Olive, J.-F.; de Oña Wilhelmi, E.; Orford, K. J.; Ostrowski, M.; Panter, M.; Paz Arribas, M.; Pedaletti, G.; Pelletier, G.; Petrucci, P.-O.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raubenheimer, B. C.; Raue, M.; Rayner, S. M.; Renaud, M.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Ruppel, J.; Sahakian, V.; Santangelo, A.; Schlickeiser, R.; Schöck, F. M.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Shalchi, A.; Sikora, M.; Skilton, J. L.; Sol, H.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Superina, G.; Szostek, A.; Tam, P. H.; Tavernet, J.-P.; Terrier, R.; Tibolla, O.; Tluczykont, M.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Venter, L.; Vialle, J. P.; Vincent, P.; Vivier, M.; Völk, H. J.; Volpe, F.; Wagner, S. J.; Ward, M.; Zdziarski, A. A.; Zech, A.

2010-02-01

Aims: Our aim is to study the very high energy (VHE; E>100 GeV) γ-ray emission from BL Lac objects and the evolution in time of their broad-band spectral energy distribution (SED). Methods: VHE observations of the high-frequency peaked BL Lac object PKS 2005-489 were made with the High Energy Stereoscopic System (HESS) from 2004 through 2007. Three simultaneous multi-wavelength campaigns at lower energies were performed during the HESS data taking, consisting of several individual pointings with the XMM-Newton and RXTE satellites. Results: A strong VHE signal, ~17σ total, from PKS 2005-489 was detected during the four years of HESS observations (90.3 h live time). The integral flux above the average analysis threshold of 400 GeV is ~3% of the flux observed from the Crab Nebula and varies weakly on time scales from days to years. The average VHE spectrum measured from ~300 GeV to ~5 TeV is characterized by a power law with a photon index, Γ = 3.20± 0.16_stat± 0.10_syst. At X-ray energies the flux is observed to vary by more than an order of magnitude between 2004 and 2005. Strong changes in the X-ray spectrum (ΔΓX ≈ 0.7) are also observed, which appear to be mirrored in the VHE band. Conclusions: The SED of PKS 2005-489, constructed for the first time with contemporaneous data on both humps, shows significant evolution. The large flux variations in the X-ray band, coupled with weak or no variations in the VHE band and a similar spectral behavior, suggest the emergence of a new, separate, harder emission component in September 2005. Supported by CAPES Foundation, Ministry of Education of Brazil.Now at Harvard-Smithsonian Center for Astrophysics, Cambridge, USA.Now at W.W. Hansen Experimental Physics Laboratory & Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, Stanford, USA.

Assessment of anthropometric indices among residents of Calabar, South-East Nigeria

PubMed Central

Egbe, Enang Ofem; Asuquo, Otu Akaninyene; Ekwere, Essien Okon; Olufemi, Fasanmade; Ohwovoriole, A. E.

2014-01-01

Background: Obesity is a risk factor for type 2 diabetes mellitus which may be addressed by application of intensive lifestyle interventions. Thus, establishing normative values of anthropometric indices in our environment is crucial. This study aimed to determine normative values of anthropometric indices of nutrition among residents of Calabar. Materials and Methods: This cross sectional observational study recruited residents of Calabar aged between 15-79 years using a multistage sampling method. Trained research assistants collected socio-demographic data and did anthropometric measurements. Results: There were 645 (56.5%) males and 489 (43.1%) females. Males had significantly lower general adiposity and hip circumference (HC) than females while females had significantly lower waist circumference (WC) and waist hip ratio (WHR) than males. The WHR increased with age particularly among males. Body mass index (BMI) also increased with age in both males and females with a peak in the middle age bracket, followed by a decline among the elderly. The mean (SD) BMI was 27.7 (5.0) kg/m2. Males had a mean (SD) BMI of 27.0 (4.4) kg/m2, while females had a mean (SD) BMI of 28.5 (5.5) kg/m2 respectively. WC correlated positively and significantly with BMI and WHR in males and females. WHR correlated positively and significantly with BMI in males and females. Conclusion: There are positive linear inter relationships between the indices of nutrition which is strongest between WC and BMI. In view of the strong independent association of DM with indices of nutrition, it is appropriate to derive normal cut-off values for WC, WHR and BMI nationally. PMID:24944936

Highly exposed Fe-N4 active sites in porous poly-iron-phthalocyanine based oxygen reduction electrocatalyst with ultrahigh performance for air cathode.

PubMed

Anandhababu, Ganesan; Abbas, Syed Comail; Lv, Jiangquan; Ding, Kui; Liu, Qin; Babu, Dickson D; Huang, Yiyin; Xie, Jiafang; Wu, Maoxiang; Wang, Yaobing

2017-02-14

Progress in the development of efficient electrocatalysts for oxygen reduction reactions is imperative for various energy systems such as metal-air batteries and fuel cells. In this paper, an innovative porous two-dimensional (2D) poly-iron-phthalocyanine (PFe-Pc) based oxygen reduction electrocatalyst created with a simple solid-state chemical reaction without pyrolysis is reported. In this strategy, silicon dioxide nanoparticles play a pivotal role in preserving the Fe-N 4 structure during the polymerization process and thereby assist in the development of a porous structure. The new polymerized phthalocyanine electrocatalyst with tuned porous structure, improved specific surface area and more exposed catalytic active sites via the 2D structure shows an excellent performance towards an oxygen reduction reaction in alkaline media. The onset potential (E = 1.033 V) and limiting current density (I = 5.58 mA cm -2 ) are much better than those obtained with the commercial 20% platinum/carbon electrocatalyst (1.046 V and 4.89 mA cm -2 ) and also show better stability and tolerance to methanol crossover. For practical applications, a zinc-air (Zn-air) battery and methanol fuel cell equipped with the PFe-Pc electrocatalyst as an air cathode reveal a high open circuit voltage and maximum power output (1.0 V and 23.6 mW cm -2 for a methanol fuel cell, and 1.6 V and 192 mW cm -2 for the liquid Zn-air battery). In addition, using the PFe-Pc electrocatalyst as an air cathode in a flexible cable-type Zn-air battery exhibits excellent performance with an open-circuit voltage of 1.409 V. This novel porous 2D PFe-Pc has been designed logically using a new, simple strategy with ultrahigh electrochemical performances in Zn-air batteries and methanol fuel cell applications.

VizieR Online Data Catalog: Galaxies morphology and IR photometry II. (Gavazzi+ 1996)

NASA Astrophysics Data System (ADS)

Gavazzi, G.; Pierini, D.; Baffa, C.; Lisi, F.; Hunt, L. K.; Randone, I.; Boselli, A.

1996-05-01

We present near-infrared H-band (1.65μm) surface photometry of 297 galaxies (mostly) in the Coma Supercluster obtained with the Arcetri NICMOS3 camera, ARNICA, mounted on the Gornergrat Infrared Telescope. Magnitudes and diameters within the 21.5mag/arcsec2 isophote, concentration indices, and total H magnitudes are derived. Combining these observations with those obtained similarly using the Calar Alto telescopes (Paper I, ) we find a strong positive correlation between the near-infrared concentration index and the galaxy H-band luminosity, and we analyze the consequent dependence of near-infrared growth-curves on H-band luminosity. For a description of the H band photometric system, see e.g. (2 data files).

Novozyme 435-catalyzed efficient acylation of 3-n-butylphthalide in organic medium.

PubMed

He, Laping; Sun, Jiong; Xu, Yan; Sun, Zhihao; Zheng, Changge

2008-01-01

Novozyme 435 could catalyze efficient acylation of 3-n-butylphthalide in organic medium. The conversion of 3-n-butylphthalide increased with the increase of hydrophobicity of solvent below that of hexane. The more available solvent was hexane. Salt hydride could control fixed water activity. The optimum water activity was 0.62. And the optimum of reaction time, velocity of agitation, dosage of Novozyme 435 and acetic anhydride to 3-n-butylphtrhalide molar ratio were 48 hours, 150 rpm, 8 mg/mL and 8:1, respectively. The conversion of 48.9% could be obtained at a water activity of 0.62 in hexane. Furthermore, Novozyme 435 had an enantioselective acylation of racemic 3-n-butylphthalide by original analysis.

Association between narcotic use and anabolic-androgenic steroid use among American adolescents.

PubMed

Denham, Bryan E

2009-01-01

Drawing on the data gathered in the 2006 Monitoring the Future study of American youth, the present research examines associations between use of narcotics and use of anabolic-androgenic steroids (AASs) among high-school seniors (n = 2,489). With independent measures and controls including sex, race, media exposure, socializing with friends, participation in recreational and school-sponsored sports, perceptions of drug use among professional athletes, and perceptions of steroid use among close friends, binary logistic regression analyses revealed significant associations between AAS use and the use of alcohol, crack cocaine, Vicodin, gamma-hydroxybutyrate (GHB), Ketamine, and Rohypnol. While use of both AASs and the narcotic drugs generally did not eclipse 5% of the sample, the numbers extend to many thousands in larger populations. Implications for health practitioners and recommendations for future research are offered. The study's limitations are noted.

A high sensitivity MEA probe for measuring real time rat brain glucose flux.

PubMed

Wei, Wenjing; Song, Yilin; Shi, Wentao; Lin, Nansen; Jiang, Tingjun; Cai, Xinxia

2014-05-15

The mammalian central nervous system (CNS) relies on a constant supply of external glucose for its undisturbed operation. This article presents an implantable Multi-Electrode Array (MEA) probe for brain glucose measurement. The MEA was implemented on Silicon-On-Insulator (SOI) wafer using Micro-Electro-Mechanical-Systems (MEMS) methods. There were 16 platinum recording sites on the probe and enzyme glucose oxidase (GOx) was immobilized on them. The glucose sensitivity of the MEA probe was as high as 489 µA mM(-1) cm(-2). 1,3-Phenylenediamine (mPD) was electropolymerized onto the Pt recording surfaces to prevent larger molecules such as ascorbic acid (AA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), and dopamine (DA) from reaching the recording sites surface. The MEA probe was implanted in the anesthetized rat striatum and responded to glucose levels which were altered by intraperitoneal injection of glucose and insulin. After the in vivo experiment, the MEA probe still kept sensitivity to glucose, these suggested that the MEA probe was reliable for glucose monitoring in brain extracellular fluid (ECF). © 2013 Published by Elsevier B.V.

Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts.

PubMed

Sharifi-Rad, M; Tayeboon, G S; Sharifi-Rad, J; Iriti, M; Varoni, E M; Razazi, S

2016-05-30

Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (α-glucosidase and α-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited α-amylase, α-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P<0.05) inhibited α-glucosidase (IC50 532.97 µg/mL), whereas conjugated phenolic extract significantly (P<0.05) inhibited α-amylase (IC50 489.73 µg/mL) and ACE (290.06 µg/mL). The enzyme inhibitory activities of the extracts were not associated with their phenolic content. Anyway, the inhibition of α-amylase, α-glucosidase and ACE, along with the antioxidant capacity of the phenolic-rich extracts, could represent a putative mechanism through which V. persica exerts its antidiabetes and antihypertension effects.

Porous Ni-Co-Mn oxides prisms for high performance electrochemical energy storage

NASA Astrophysics Data System (ADS)

Zhao, Jianbo; Li, Man; Li, Junru; Wei, Chengzhen; He, Yuyue; Huang, Yixuan; Li, Qiaoling

2017-12-01

Porous Ni-Co-Mn oxides prisms have been successfully synthesized via a facile route. The process involves the preparation of nickel-cobalt-manganese acetate hydroxide by a simple co-precipitation method and subsequently the thermal treatment. The as-synthesized Ni-Co-Mn oxides prisms had a large surface area (96.53 m2 g-1) and porous structure. As electrode materials for supercapacitors, porous Ni-Co-Mn oxides prisms showed a high specific capacitance of 1623.5 F g-1 at 1.0 A g-1. Moreover, the porous Ni-Co-Mn oxides prisms were also employed as positive electrode materials to assemble flexible solid-state asymmetric supercapacitors. The resulting flexible device had a maximum volumetric energy density (0.885 mW h cm-3) and power density (48.9 mW cm-3). Encouragingly, the flexible device exhibited good cycling stability with only about 2.2% loss after 5000 charge-discharge cycles and excellent mechanical stability. These results indicate that porous Ni-Co-Mn oxides prisms have the promising application in high performance electrochemical energy storage.

Development of a measure of work motivation for a meta-theory of motivation.

PubMed

Ryan, James C

2011-06-01

This study presents a measure of work motivation designed to assess the motivational concepts of the meta-theory of motivation. These concepts include intrinsic process motivation, goal internalization motivation, instrumental motivation, external self-concept motivation, and internal self-concept motivation. Following a process of statement development and identification, six statements for each concept were presented to a sample of working professionals (N = 330) via a paper-and-pencil questionnaire. Parallel analysis supported a 5-factor solution, with a varimax rotation identifying 5 factors accounting for 48.9% of total variance. All 5 scales had Cronbach alpha coefficients above .70. Limitations of the newly proposed questionnaire and suggestions for its further development and use are discussed.

Match Physical Performance of Elite Female Soccer Players During International Competition.

PubMed

Datson, Naomi; Drust, Barry; Weston, Matthew; Jarman, Ian H; Lisboa, Paulo J; Gregson, Warren

2017-09-01

Datson, N, Drust, B, Weston, M, Jarman, IH, Lisboa, P, and Gregson, W. Match physical performance of elite female soccer players during international competition. J Strength Cond Res 31(9): 2379-2387, 2017-The purpose of this study was to provide a detailed analysis of the physical demands of competitive international female soccer match play. A total of 148 individual match observations were undertaken on 107 outfield players competing in competitive international matches during the 2011-2012 and 2012-2013 seasons, using a computerized tracking system (Prozone Sports Ltd., Leeds, England). Total distance and total high-speed running distances were influenced by playing position, with central midfielders completing the highest (10,985 ± 706 m and 2,882 ± 500 m) and central defenders the lowest (9,489 ± 562 m and 1,901 ± 268 m) distances, respectively. Greater total very high-speed running distances were completed when a team was without (399 ± 143 m) compared to with (313 ± 210 m) possession of the ball. Most sprints were over short distances with 76% and 95% being less than 5 and 10 m, respectively. Between half reductions in physical performance were present for all variables, independent of playing position. This study provides novel findings regarding the physical demands of different playing positions in competitive international female match play and provides important insights for physical coaches preparing elite female players for competition.

MicroRNAs expression profile in solid and unicystic ameloblastomas.

PubMed

Setién-Olarra, A; Marichalar-Mendia, X; Bediaga, N G; Aguirre-Echebarria, P; Aguirre-Urizar, J M; Mosqueda-Taylor, A

2017-01-01

Odontogenic tumors (OT) represent a specific pathological category that includes some lesions with unpredictable biological behavior. Although most of these lesions are benign, some, such as the ameloblastoma, exhibit local aggressiveness and high recurrence rates. The most common types of ameloblastoma are the solid/multicystic (SA) and the unicystic ameloblastoma (UA); the latter considered a much less aggressive entity as compared to the SA. The microRNA system regulates the expression of many human genes while its deregulation has been associated with neoplastic development. The aim of the current study was to determine the expression profiles of microRNAs present in the two most common types of ameloblastomas. MicroRNA expression profiles were assessed using TaqMan® Low Density Arrays (TLDAs) in 24 samples (8 SA, 8 UA and 8 control samples). The findings were validated using quantitative RTqPCR in an independent cohort of 19 SA, 8 UA and 19 dentigerous cysts as controls. We identified 40 microRNAs differentially regulated in ameloblastomas, which are related to neoplastic development and differentiation, and with the osteogenic process. Further validation of the top ranked microRNAs revealed significant differences in the expression of 6 of them in relation to UA, 7 in relation to SA and 1 (miR-489) that was related to both types. We identified a new microRNA signature for the ameloblastoma and for its main types, which may be useful to better understand the etiopathogenesis of this neoplasm. In addition, we identified a microRNA (miR-489) that is suggestive of differentiating among solid from unicystic ameloblastoma.

MicroRNAs expression profile in solid and unicystic ameloblastomas

PubMed Central

Setién-Olarra, A.; Bediaga, N. G.; Aguirre-Echebarria, P.; Aguirre-Urizar, J. M.; Mosqueda-Taylor, A.

2017-01-01

Objectives Odontogenic tumors (OT) represent a specific pathological category that includes some lesions with unpredictable biological behavior. Although most of these lesions are benign, some, such as the ameloblastoma, exhibit local aggressiveness and high recurrence rates. The most common types of ameloblastoma are the solid/multicystic (SA) and the unicystic ameloblastoma (UA); the latter considered a much less aggressive entity as compared to the SA. The microRNA system regulates the expression of many human genes while its deregulation has been associated with neoplastic development. The aim of the current study was to determine the expression profiles of microRNAs present in the two most common types of ameloblastomas. Material & methods MicroRNA expression profiles were assessed using TaqMan® Low Density Arrays (TLDAs) in 24 samples (8 SA, 8 UA and 8 control samples). The findings were validated using quantitative RTqPCR in an independent cohort of 19 SA, 8 UA and 19 dentigerous cysts as controls. Results We identified 40 microRNAs differentially regulated in ameloblastomas, which are related to neoplastic development and differentiation, and with the osteogenic process. Further validation of the top ranked microRNAs revealed significant differences in the expression of 6 of them in relation to UA, 7 in relation to SA and 1 (miR-489) that was related to both types. Conclusion We identified a new microRNA signature for the ameloblastoma and for its main types, which may be useful to better understand the etiopathogenesis of this neoplasm. In addition, we identified a microRNA (miR-489) that is suggestive of differentiating among solid from unicystic ameloblastoma. PMID:29053755

Late developments in the field of heat recovery

NASA Astrophysics Data System (ADS)

McFarlan, A. I.

Developments to reduce the first cost and operating expense of large building air conditioning systems, with emphasis on heat transfer are described. The 3 pipe wide range coils dissipate part of the summer cooling load directly to the outside of the building without passing thru the water chillers. Tank circuits to automatically cycle water thru storage tanks can reduce the refrigeration load about 35% during the peak day period. Means to produce above 48.9 C hot water economically for winter heating and summer dissipation of internal heat are described. A heat balance is maintained automatically to remove only the excess winter heat beyond that which can be usefully recycled or stored.

100th anniversary of the birth of B M Pontecorvo (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 2 September 2013)

NASA Astrophysics Data System (ADS)

2014-05-01

A scientific session "Prospects of Studies in Neutrino Particle Physics and Astrophysics," of the Physical Sciences Division of the Russian Academy of Sciences (DPS RAS), devoted to the centenary of B M Pontecorvo, was held on 2-3 September 2014 at the JINR international conference hall (Dubna, Moscow region).The following reports were put on the session agenda as posted on the website http://www.gpad.ac.ru of the RAS Physical Sciences Division: (1) Kudenko Yu G (Institute for Nuclear Research, RAS, Moscow; Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow region; National Research Nuclear University MEPhI, Moscow) "Long-baseline neutrino accelerator experiments: results and prospects";(2) Spiering Ch (Deutsches Elektronen-Synchrotron (DESY), Germany) "Results obtained by ICECUBE and prospects of neutrino astronomy";(3) Barabash A S (Alikhanov Institute for Theoretical and Experimental Physics, Moscow) "Double beta decay experiments: current status and prospects";(4) Bilenky S M (Joint Institute for Nuclear Research, Dubna, Moscow region; Technische Universitat M'unchen, Garching, Germany) "Bruno Pontecorvo and the neutrino";(5) Olshevskiy A G (Joint Institute for Nuclear Research, Dubna, Moscow region) "Reactor neutrino experiments: results and prospects";(6) Gavrin V N (Institute for Nuclear Research, RAS, Moscow) "Low-energy neutrino research at the Baksan Neutrino Laboratory";(7) Gorbunov D S (Institute for Nuclear Research, RAS, Moscow): "Sterile neutrinos and their role in particle physics and cosmology";(8) Derbin A V (Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Leningrad region) "Solar neutrino experiments";(9) Rubakov V A (Institute for Nuclear Research, RAS, Moscow) "Prospects of studies in the field of neutrino particle physics and astrophysics." An article by V N Gavrin, close in essence to talk 6, was published in Usp. Fiz. Nauk 181 (9), 975 (2011) [Phys. Usp. 54 (9) 941 (2011)]. Articles by V A Rubakov, close in essence to talk 9, were published in Usp. Fiz. Nauk 182 (10) 1017 (2012); 181 (6) 655 (2011) [Phys. Usp. 55 (10) 949 (2012); 54 (6) 633 (2011)]. Articles based on talks 1-5, 7, and 8 are published below. • Long-baseline neutrino accelerator experiments: results and prospects, Yu G Kudenko Physics-Uspekhi, 2014, Volume 57, Number 5, Pages 462-469 • High-energy neutrino astronomy: a glimpse of the promised land, Ch Spiering Physics-Uspekhi, 2014, Volume 57, Number 5, Pages 470-481 • Double beta decay experiments: current status and prospects, A S Barabash Physics-Uspekhi, 2014, Volume 57, Number 5, Pages 482-488 • Bruno Pontecorvo and the neutrino, S M Bilenky Physics-Uspekhi, 2014, Volume 57, Number 5, Pages 489-496 • Reactor neutrino experiments: results and prospects, A G Olshevskiy Physics-Uspekhi, 2014, Volume 57, Number 5, Pages 497-502 • Sterile neutrinos and their role in particle physics and cosmology, D S Gorbunov Physics-Uspekhi, 2014, Volume 57, Number 5, Pages 503-511 • Solar neutrino experiments, A V Derbin Physics-Uspekhi, 2014, Volume 57, Number 5, Pages 512-524

The role of proline substitutions within flexible regions on thermostability of luciferase.

PubMed

Yu, Haoran; Zhao, Yang; Guo, Chao; Gan, Yiru; Huang, He

2015-01-01

Improving the stability of firefly luciferase has been a critical issue for its wider industrial applications. Studies about hyperthermophile proteins show that flexibility could be an effective indicator to find out weak spots to engineering thermostability of proteins. However, the relationship among flexibility, activity and stability in most of proteins is unclear. Proline is the most rigid residue and can be introduced to rigidify flexible regions to enhance thermostability of proteins. We firstly apply three different methods, molecular dynamics (MD) simulation, B-FITTER and framework rigidity optimized dynamics algorithm (FRODA) to determine the flexible regions of Photinus pyralis luciferase: Fragment 197-207; Fragment 471-481 and Fragment 487-495. Then, introduction of proline is used to rigidify these flexible regions. Two mutants D476P and H489P within most flexible regions are finally designed. In the results, H489P mutant shows improved thermostability while maintaining its catalytic efficiency compared to that of wild type luciferase. Flexibility analysis confirms that the overall rigidity and local rigidity of H489P mutant are greatly strengthened. D476P mutant shows decreased thermosatbility and the reason for this is elucidated at the molecular level. S307P mutation is randomly chosen outside the flexible regions as a control. Thermostability analysis shows that S307P mutation has decreased kinetic stability and enhanced thermodynamic stability. Copyright © 2014 Elsevier B.V. All rights reserved.

Effect of pasture size on behavioural synchronization and spacing in German Blackface ewes (Ovis aries).

PubMed

Hauschildt, Verena; Gerken, Martina

2016-03-01

This study aims to assess plot size related changes in spacing and behavioural synchronization in a herd of 14 German Blackface ewes kept on three different pasture sizes: S (126m(2)), M (1100m(2)), and L (11,200m(2)). In direct field observations, behaviour and nearest neighbour distance were recorded individually. Additionally, interindividual and nearest neighbour distances were derived from aerial photographs of the herd taken on plot sizes S and M. Nearest neighbour distances <1m accounted for more than 60% of observations, and were more frequent on plot size L than on plot sizes S (Z=3.3; p<0.01) and M (Z=3.2; p<0.01). Average interindividual distances were significantly smaller on S (4.89±2.62m) than on M plots (5.99±3.06m; t=7.3; p<0.01). Synchronization tended to increase with plot size (K(S)=0.42; K(M)=0.52; K(L)=0.66), but was not accompanied by a concomitant increase in dispersion. Aerial photography proved a valuable tool in the analysis of spacing behaviour as intraindividual repeatability of the derived distances was highly significant (Kendall's W between 0.32 and 0.58; p<0.01). The sheep kept small distances on all plot sizes, thus the high degree of behavioural synchronization might be mainly attributed to the motivation for close proximity to any conspecific. Copyright © 2015 Elsevier B.V. All rights reserved.

Self-pressurization of a flightweight liquid hydrogen storage tank subjected to low heat flux

NASA Technical Reports Server (NTRS)

Hasan, M. M.; Lin, C. S.; Vandresar, N. T.

1991-01-01

Results are presented for an experimental investigation of self-pressurization and thermal stratification of a 4.89 cu m liquid hydrogen (LH2) storage tank subjected to low heat flux (0.35, 2.0, and 3.5 W/sq m) under normal gravity conditions. Tests were performed at fill levels of 83 to 84 percent (by volume). The LH2 tank was representative of future spacecraft tankage, having a low mass-to-volume ratio and high performance multilayer thermal insulation. Results show that the pressure rise rate and thermal stratification increase with increasing heat flux. At the lowest heat flux, the pressure rise rate is comparable to the homogenous rate, while at the highest heat flux, the rate is more than three times the homogeneous rate. It was found that initial conditions have a significant impact on the initial pressure rise rate. The quasi-steady pressure rise rates are nearly independent of the initial condition after an initial transient period has passed.

Studies on the antioxidant properties of Tualang honey of Malaysia.

PubMed

Mohamed, Mahaneem; Sirajudeen, Kns; Swamy, M; Yaacob, Nik Soriani; Sulaiman, Siti Amrah

2009-10-15

Honey has been used since ancient times for its nutritional as well as curative properties. Tualang honey is collected from wild honey bees' hives on Tualang trees found in the Malaysian rain forest. It has been used traditionally for the treatment of various diseases, where its therapeutic value has partly been related to its antioxidant properties. This study therefore assessed the colour intensity, total phenolic content, antioxidant activity and antiradical activity of gamma irradiated Tualang Honey. The colour intensity at ABS₄₅₀ was 489.5 ± 1.7 mAU, total phenolic content was 251.7 ± 7.9 mg (gallic acid) /Kg honey, total antioxidant activity by FRAP assay was 322.1 ± 9.7 (µM Fe(II)) and the antiradical activity by DPPH assay was 41.30 ± 0.78 (% inhibition). The data confirms that the antioxidant properties of gamma irradiated Tualang honey are similar to other types of honeys reported in the literature.

Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.

PubMed

Rempel, Viktor; Volz, Nicole; Gläser, Franziska; Nieger, Martin; Bräse, Stefan; Müller, Christa E

2013-06-13

The orphan G-protein-coupled receptor GPR55, which is activated by 1-lysophosphatidylinositol and interacts with cannabinoid (CB) receptor ligands, has been proposed as a new potential drug target for the treatment of diabetes, Parkinson's disease, neuropathic pain, and cancer. We applied β-arrestin assays to identify 3-substituted coumarins as a novel class of antagonists and performed an extensive structure-activity relationship study for GPR55. Selectivity versus the related receptors CB1, CB2, and GPR18 was assessed. Among the 7-unsubstituted coumarins selective, competitive GPR55 antagonists were identified, such as 3-(2-hydroxybenzyl)-5-isopropyl-8-methyl-2H-chromen-2-one (12, PSB-SB-489, IC50 = 1.77 μM, pA2 = 0.547 μM). Derivatives with long alkyl chains in position 7 were potent, possibly allosteric GPR55 antagonists which showed ancillary CB receptor affinity. 7-(1,1-Dimethyloctyl)-5-hydroxy-3-(2-hydroxybenzyl)-2H-chromen-2-one (69, PSB-SB-487, IC50 = 0.113 μM, KB = 0.561 μM) and 7-(1,1-dimethylheptyl)-5-hydroxy-3-(2-hydroxybenzyl)-2H-chromen-2-one (67, PSB-SB-1203, IC50 = 0.261 μM) were the most potent GPR55 antagonists of the present series.

Biobleaching of Industrial Important Dyes with Peroxidase Partially Purified from Garlic

PubMed Central

Osuji, Akudo Chigozirim; Eze, Sabinus Oscar O.; Osayi, Emmanuel Emeka; Chilaka, Ferdinand Chiemeka

2014-01-01

An acidic peroxidase was extracted from garlic (Allium sativum) and was partially purified threefold by ammonium sulphate precipitation, dialysis, and gel filtration chromatography using sephadex G-200. The specific activity of the enzyme increased from 4.89 U/mg after ammonium sulphate precipitation to 25.26 U/mg after gel filtration chromatography. The optimum temperature and pH of the enzyme were 50°C and 5.0, respectively. The Km and V max for H2O2 and o-dianisidine were 0.026 mM and 0.8 U/min, and 25 mM and 0.75 U/min, respectively. Peroxidase from garlic was effective in decolourizing Vat Yellow 2, Vat Orange 11, and Vat Black 27 better than Vat Green 9 dye. For all the parameters monitored, the decolourization was more effective at a pH range, temperature, H2O2 concentration, and enzyme concentration of 4.5–5.0, 50°C, 0.6 mM, and 0.20 U/mL, respectively. The observed properties of the enzyme together with its low cost of extraction (from local sources) show the potential of this enzyme for practical application in industrial wastewater treatment especially with hydrogen peroxide. These Vat dyes also exhibited potentials of acting as peroxidase inhibitors at alkaline pH range. PMID:25401128

A collection of non-human primate computed tomography scans housed in MorphoSource, a repository for 3D data

PubMed Central

Copes, Lynn E.; Lucas, Lynn M.; Thostenson, James O.; Hoekstra, Hopi E.; Boyer, Doug M.

2016-01-01

A dataset of high-resolution microCT scans of primate skulls (crania and mandibles) and certain postcranial elements was collected to address questions about primate skull morphology. The sample consists of 489 scans taken from 431 specimens, representing 59 species of most Primate families. These data have transformative reuse potential as such datasets are necessary for conducting high power research into primate evolution, but require significant time and funding to collect. Similar datasets were previously only available to select research groups across the world. The physical specimens are vouchered at Harvard’s Museum of Comparative Zoology. The data collection took place at the Center for Nanoscale Systems at Harvard. The dataset is archived on MorphoSource.org. Though this is the largest high fidelity comparative dataset yet available, its provisioning on a web archive that allows unlimited researcher contributions promises a future with vastly increased digital collections available at researchers’ finger tips. PMID:26836025

Energize Africa Act of 2014

THOMAS, 113th Congress

Sen. Menendez, Robert [D-NJ

2014-06-19

Senate - 07/24/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 489. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Pressurization and expulsion of a flightweight liquid hydrogen tank

NASA Technical Reports Server (NTRS)

Vandresar, N. T.; Stochl, R. J.

1993-01-01

Experimental results are presented for pressurization and expulsion of a flight-weight 4.89 cu m liquid hydrogen storage tank under normal gravity conditions. Pressurization and expulsion times are parametrically varied to study the effects of longer transfer times expected in future space flight applications. It is found that the increase in pressurant consumption with increased operational time is significant at shorter pressurization or expulsion durations and diminishes as the duration lengthens. Gas-to-wall heat transfer in the ullage is the dominant mode of energy exchange, with more than 50 percent of the pressurant energy being lost to tank wall heating in expulsions and the long duration pressurizations. Advanced data analysis will require a multidimensional approach combined with improved measurement capabilities of liquid-vapor interfacial transport phenomena.

[Environmental impact of a public hospital in the city of Lima, Peru].

PubMed

Bambarén-Alatrista, Celso; Alatrista-Gutiérrez de Bambarén, María del Socorro

2014-01-01

The operation of hospitals produces negative effects on the environment which contributes to air pollution and climate change. The institution in this study is a category III health care facility located in the city of Lima. It generates 4.89 kg/bed/day of solid waste, and consumes 1.36 m3/bed/day of water; 25.22 kWh/bed/day of electricity, and 2.76 liters/bed/day of fuel. The level of PM10 and measured parameters of disposal to the public network are within legal limits, while mobile source noise exceeds the maximum allowable limit. The institution releases into the atmosphere 2,291 tons of CO2 equivalents per year. In conclusion, the institution studied generates a negative impact on the environment.

Preliminary study on filamentous particle distribution in septic tank effluent and their impact on filter cake development.

PubMed

Spychała, Marcin; Nieć, Jakub; Pawlak, Maciej

2013-01-01

In this paper, the preliminary study on the impact of filamentous particles (FP) in the septic tank effluent (STE) on filter cake (FC) development was presented. The number, length and diameter (30 p./cm3, 451 and 121 microm, respectively, on average) of FPs were measured using microscope image analysis of STE samples condensed using a vacuum evaporation set. Results of this study showed, that 0.73% of volatile suspended solids (VSSs) mass from the STE occurs in the form of FPs. No correlation between FP total mass and VSS was found. An experiment with a layer of FPs simulated by ground toilet paper was conducted and showed the impact of this layer (4.89 mg/cm2) on wastewater hydraulic conductivity--for an FC with FPs (FC-FP), hydraulic conductivity was seven times lower than for the FC without the FP layer, and on outflow quality (lower concentration of organic matter expressed as chemical oxygen demand (COD) in effluent from the FC-FP filter than in the effluent from the FC filter: 618 and 732 gO2/m3, respectively). Despite a relatively small amount of FPs in STE solids (as volume fraction), they play an important role in FC development due to their relatively high length and low degradability. Probably relatively small pores of the FC containing FPs (FC-FP) caused a small particle blocking and a decrease in permeability.

Blackfoot River Land Settlement Act of 2011

THOMAS, 112th Congress

Sen. Crapo, Mike [R-ID

2011-05-25

Senate - 08/02/2012 Placed on Senate Legislative Calendar under General Orders. Calendar No. 489. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Yo-Yo Intermittent Recovery Test Performance in Subelite Gaelic Football Players From Under Thirteen to Senior Age Groups.

PubMed

Roe, Mark; Malone, Shane

2016-11-01

Roe, M and Malone, S. Yo-Yo intermittent recovery test performance in subelite Gaelic football players from under thirteen to senior age groups. J Strength Cond Res 30 (11): 3187-3193, 2016-Gaelic football is indigenous to Ireland and has similar locomotion profiles to soccer and Australian Football. Given the increasing attention on long-term player development, investigations on age-related variation in Yo-Yo intermittent recovery test level 1 (Yo-YoIR1) performance may provide useful information in talent identification, program design, and player monitoring. Therefore, the aim of this study was to evaluate Yo-YoIR1 performance across Gaelic football age groups. Male participants (n = 355) were recruited from division one, Gaelic football teams. Participants were allocated to one of the 7 groups according to respective age groups from under 13 (U13), under 14, under 15 (U15), under 16 (U16), minor, under 21 (U21), to senior age groups. Total Yo-YoIR1 distance (m) increased progressively from U13 (885 ± 347 m) to U16 (1,595 ± 380 m) equating to a rate of change of 180.2%. In comparison to U13, total distance at minor (1,206 ± 327 m) increased by 136.4%. Subsequent increases were observed in U21 (1,585 ± 445 m) and senior players (2,365 ± 489). Minimum (800-880 m) and maximum (2,240-2,280 m) total distances were comparable for U15, U16, and U21 players. Differences in total distance (m) for all age groups were statistically significant when compared to U13 players (p < 0.002). In comparison to U13 players, the magnitude of differences between age groups for total distance was deemed to be large (effect size > 0.8). Similar trends were observed for maximum velocity and estimated V[Combining Dot Above]O2max. The evolution of Yo-YoIR1 performance in Gaelic football players from adolescents to adulthood highlights how maturation may influence sport-related running ability. Changes in Yo-YoIR1 performance should be closely monitored to optimize interventions for individuals transitioning across age groups.

In situ field application of electrokinetic remediation for an As-, Cu-, and Pb-contaminated rice paddy site using parallel electrode configuration.

PubMed

Jeon, Eun-Ki; Jung, Ji-Min; Ryu, So-Ri; Baek, Kitae

2015-10-01

The applicability of an in situ electrokinetic process with a parallel electrode configuration was evaluated to treat an As-, Cu-, and Pb-contaminated paddy rice field in full scale (width, 17 m; length, 12.2 m; depth, 1.6 m). A constant voltage of 100 V was supplied and electrodes were spaced 2 m apart. Most As, Cu, and Pb were bound to Fe oxide and the major clay minerals in the test site were kaolinite and muscovite. The electrokinetic system removed 48.7, 48.9, and 54.5 % of As, Cu, and Pb, respectively, from the soil during 24 weeks. The removal of metals in the first layer (0-0.4 m) was higher than that in the other three layers because it was not influenced by groundwater fluctuation. Fractionation analysis showed that As and Pb bound to amorphous Fe and Al oxides decreased mainly, and energy consumption was 1.2 kWh/m(3). The standard deviation of metal concentration in the soil was much higher compared to the hexagonal electrode configuration because of a smaller electrical active area; however, the electrode configuration removed similar amounts of metals compared to the hexagonal system. From these results, it was concluded that the electrokinetic process could be effective at remediating As-, Cu-, and Pb-contaminated paddy rice field in situ.

Distribution profile, health risk and elimination of model atmospheric SVOCs associated with a typical municipal garbage compressing station in Guangzhou, South China

NASA Astrophysics Data System (ADS)

Li, Guiying; Sun, Hongwei; Zhang, Zhengyong; An, Taicheng; Hu, Jianfang

2013-09-01

Semi-volatile organic compounds (SVOCs) air pollution caused by municipal garbage compressing process was investigated at a garbage compressing station (GCS). The most abundant contaminants were phthalate esters (PAEs), followed by polycyclic aromatic hydrocarbons (PAHs) and organic chlorinated pesticides (OCPs). ∑16PAHs concentrations ranged from 58.773 to 68.840 ng m-3 in gas and from 6.489 to 17.291 ng m-3 in particulate phase; ∑20OCPs ranged from 4.181 to 5.550 ng m-3 and from 0.823 to 2.443 ng m-3 in gas and particulate phase, respectively; ∑15PAEs ranged from 46.498 to 87.928 ng m-3 and from 414.765 to 763.009 ng m-3 in gas and particulate phase. Lung-cancer risk due to PAHs exposure was 1.13 × 10-4. Both non-cancer and cancer risk levels due to OCPs exposure were acceptable. Non-cancer hazard index of PAEs was 4.57 × 10-3, suggesting safety of workers as only exposure to PAEs at GCS. At pilot scale, 60.18% of PAHs, 70.89% of OCPs and 63.2% of PAEs were removed by an integrated biotrickling filter-photocatalytic reactor at their stable state, and health risk levels were reduced about 50%, demonstrating high removal capacity of integrated reactor.

Comparison of long-term safety of fixed-dose combinations azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide.

PubMed

Neutel, Joel M; Cushman, William C; Lloyd, Eric; Barger, Bruce; Handley, Alison

2017-09-01

This 52-week, randomized, open-label study evaluated long-term safety/tolerability of fixed-dose combination azilsartan medoxomil/chlorthalidone (AZL-M/CLD) vs fixed-dose combination olmesartan medoxomil/hydrochlorothiazide (OLM/HCTZ) in patients with essential hypertension (stage 2; clinic systolic blood pressure 160-190 mm Hg). Initial AZL-M/CLD 40/12.5 mg/d (n=418) or OLM/HCTZ 20/12.5 mg/d (n=419) could be uptitrated during weeks 4 to 52 (AZL-M/CLD to 80/25 mg; OLM/HCTZ to 40/25 mg [United States] or 20/25 mg [Europe]) to meet blood pressure targets. Treatment-emergent adverse events/serious adverse events occurred in 78.5%/5.7% of patients taking AZL-M/CLD vs 76.4%/6.2% taking OLM/HCTZ. The most frequent adverse events were dizziness (16.3% vs 12.6%), blood creatinine increase (21.5% vs 8.6%), headache (7.4% vs 11.0%), and nasopharyngitis (12.2% vs 11.5%). Hypokalemia was uncommon (1.0% vs 0.7%). Greater blood pressure reductions with AZL-M/CLD by week 2 were maintained throughout the study, despite less uptitration (32.3% vs 48.9% with OLM/HCTZ). Fixed-dose combination AZL-M/CLD showed an encouraging benefit-risk profile when used per standard clinical practice in a titrate-to-target strategy. ©2017 Wiley Periodicals, Inc.

Comparison of extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation.

PubMed

Biscotti, Mauer; Yang, Jonathan; Sonett, Joshua; Bacchetta, Matthew

2014-11-01

This study compared differences in patient outcomes and operative parameters for extracorporeal membrane oxygenation (ECMO) versus cardiopulmonary bypass (CPB) in patients undergoing lung transplants. Between January 1, 2008, and July 13, 2013, 316 patients underwent lung transplants at our institution, 102 requiring intraoperative mechanical cardiopulmonary support (CPB, n=55; ECMO, n=47). We evaluated survival, blood product transfusions, bleeding complications, graft dysfunction, and rejection. Intraoperatively, the CPB group required more cell saver volume (1123±701 vs 814±826 mL; P=.043), fresh-frozen plasma (3.64±5.0 vs 1.51±3.2 units; P=.014), platelets (1.38±1.6 vs 0.43±1.25 units; P=.001), and cryoprecipitate (4.89±6.3 vs 0.85±2.8 units; P<.001) than the ECMO group. Postoperatively, the CPB group received more platelets (1.09±2.6 vs 0.13±0.39 units; P=.013) and was more likely to have bleeding (15 [27.3%] vs 3 [6.4%]; P=.006) and reoperation (21 [38.2%] vs 7 [14.9%]; P=.009]. The CPB group had higher rates of primary graft dysfunction at 24 and 72 hours (41 [74.5%] vs 23 [48.9%]; P=.008; and 42 [76.4%] vs 26 [56.5%]; P=.034; respectively). There were no differences in 30-day and 1-year survivals. Relative to CPB, the ECMO group required fewer transfusions and had less bleeding, fewer reoperations, and less primary graft dysfunction. There were no statistically significant survival differences at 30 days or 1 year. Copyright © 2014 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

70,489 primary care encounters: retrospective analysis of morbidity at a primary care centre in Ireland.

PubMed

Molony, D; Beame, C; Behan, W; Crowley, J; Dennehy, T; Quinlan, M; Cullen, W

2016-11-01

While considerable changes are happening in primary care in Ireland and considerable potential exists in intelligence derived from practice-based data to inform these changes, relatively few large-scale general morbidity surveys have been published. To examine the most common reasons why people attend primary care, specifically 'reasons for encounter' (RFEs) among the general practice population and among specific demographic groups (i.e., young children and older adults). We retrospectively examined clinical encounters (which had a diagnostic code) over a 4-year time period. Descriptive analyses were conducted on anonymised data. 70,489 RFEs consultations were recorded (mean 13.53 recorded RFEs per person per annum) and consultations involving multiple RFEs were common. RFE categories for which codes were most commonly recorded were: 'general/unspecified' (31.6 %), 'respiratory' (15.4 %) and 'musculoskeletal' (12.6 %). Most commonly recorded codes were: 'medication renewal' (6.8 %), 'cough' (6.6 %), and 'health maintenance/prevention' (5.8 %). There was considerable variation in the number of RFEs recorded per age group. 6239 RFEs (8.9 %) were recorded by children under 6 years and 15,295 RFEs (21.7 %) were recorded by adults aged over 70. RFEs recorded per calendar month increased consistently through the study period and there was a marked seasonal and temporal variation in the number of RFEs recorded. Practice databases can generate intelligence on morbidity and health service utilisation in the community. Future research to optimise diagnostic coding at a practice level and to promote this activity in a more representative sample of practices is a priority.

Alaska Safe Families and Villages Act of 2011

THOMAS, 112th Congress

Sen. Begich, Mark [D-AK

2011-06-14

Senate - 11/10/2011 Committee on Indian Affairs. Hearings held. Hearings printed: S.Hrg. 112-489. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

27 CFR 19.489 - Marks on cases filled in processing.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., for transfer to any customs bonded warehouses, for transfer to foreign trade zones, or for use as... (6) Labels or data describing the contents for commercial identification or accounting purposes or...

75 FR 14243 - Research, Engineering And Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering And Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. Time and Date: April 21, 2010--9 a.m. to 5 p.m...

77 FR 54648 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-05

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. TIME AND DATE: September 26, 2012--9 a.m. to 4 p.m...

Extremely Rapid X-Ray Flares of TeV Blazars in the RXTE Era

NASA Astrophysics Data System (ADS)

Zhu, S. F.; Xue, Y. Q.; Brandt, W. N.; Cui, W.; Wang, Y. J.

2018-01-01

Rapid flares from blazars in very high-energy (VHE) γ-rays challenge the common understanding of jets of active galactic nuclei (AGNs). The same population of ultra-relativistic electrons is often thought to be responsible for both X-ray and VHE emission. We thus systematically searched for X-ray flares at sub-hour timescales of TeV blazars in the entire Rossi X-ray Timing Explorer archival database. We found rapid flares from PKS 2005‑489 and S5 0716+714, and a candidate rapid flare from 1ES 1101‑232. In particular, the characteristic rise timescale of PKS 2005‑489 is less than half a minute, which, to our knowledge, is the shortest among known AGN flares at any wavelengths. The timescales of these rapid flares indicate that the size of the central supermassive black hole is not a hard lower limit on the physical size of the emission region of the flare. PKS 2005‑489 shows possible hard lags in its flare, which could be attributed to particle acceleration (injection); its flaring component has the hardest spectrum when it first appears. For all flares, the flaring components show similar hard spectra with {{Γ }}=1.7{--}1.9, and we estimate the magnetic field strength B ∼ 0.1–1.0 G by assuming synchrotron cooling. These flares could be caused by inhomogeneity of the jets. Models that can only produce rapid γ-ray flares but little synchrotron activity are less favorable.

76 FR 12404 - Research, Engineering and Development Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. Time and Date: April 20, 2011--9:30 a.m. to 4 p.m...

Antibody to hepatitis B core antigen levels in the natural history of chronic hepatitis B: a prospective observational study.

PubMed

Jia, Wei; Song, Liu-Wei; Fang, Yu-Qing; Wu, Xiao-Feng; Liu, Dan-Yang; Xu, Chun; Wang, Xiao-Mei; Wang, Wen; Lv, Dong-Xia; Li, Jun; Deng, Yong-Qiong; Wang, Yan; Huo, Na; Yu, Min; Xi, Hong-Li; Liu, Dan; Zhou, Yi-Xing; Wang, Gui-Qiang; Xia, Ning-Shao; Zhang, Ming-Xiang

2014-12-01

Previous studies have revealed antibody to hepatitis B core antigen (anti-HBc) levels as a predictor of treatment response in hepatitis B early antigen (HBeAg)-positive chronic hepatitis B (CHB) patients in both interferon and nucleos(t)ide analog therapy cohorts. However, there is no information about anti-HBc levels in the natural history of CHB. This study aimed to define anti-HBc levels of different phases in the natural history of CHB. Two hundred eleven treatment-naive CHB patients were included in the study. They were classified into 4 phases: immune tolerance (IT) phase (n = 39), immune clearance (IC) phase (n = 48), low or no-replicative (LR) phase (n = 55), and HBeAg-negative hepatitis (ENH, n = 69). Fifty patients who were HBsAg negative and anti-HBc positive were also recruited as past HBV infection (PBI) control group. Anti-HBc levels were measured by a newly developed double-sandwich immunoassay. Correlation of anti-HBc levels with alanine aminotransferase (ALT) and other HBV-related markers within each phase was performed. Serum anti-HBc levels were statistically significant between patients in different phases of CHB (P < 0.001). The median anti-HBc levels were: IT (3.17 log 10 IU/mL), IC (4.39 log 10 IU/mL), LR (3.29 log 10 IU/mL), ENH (4.12 log 10 IU/mL), and PBI (0.61 log 10 IU/mL). There existed a strong correlation in IC (r = 0.489, P < 0.001), a poor correlation in ENH (r = 0.275, P = 0.042), and no correlation in patients with ALT reached 5 times upper limit of normal (r = 0.120, P = 0.616). Anti-HBc levels show significant differences during the natural course of CHB. These results may provide some potentially useful insights into hepatitis B pathogenesis and immune activation against hepatitis B virus.

The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays.

PubMed

Zhang, Chunyan; Bai, Nan; Huang, Wenrong; Zhang, Pengjun; Luo, Yuan; Men, Shasha; Wen, Ting; Tong, Hongli; Wang, Shuhong; Tian, Ya-Ping

2016-10-01

Currently, the diagnosis of acute graft-versus-host disease (aGVHD) is mainly based on clinical symptoms and biopsy results. This study was designed to further explore new no noninvasive biomarkers for aGVHD prediction/diagnosis. We profiled miRNAs in serum pools from patients with aGVHD (grades II-IV) (n = 9) and non-aGVHD controls (n = 9) by real-time qPCR-based TaqMan MicroRNA arrays. Then, predictive models were established using related miRNAs (n = 38) and verified by a double-blind trial (n = 54). We found that miR-411 was significantly down regulated when aGVHD developed and recovered when aGVHD was controlled, which demonstrated that miR-411 has potential as an indicator for aGVHD monitoring. We developed and validated a predictive model and a diagnostic model for aGVHD. The predictive model included two miRNAs (miR-26b and miR-374a), which could predict an increased risk for aGVHD 1 or 2 weeks in advance, with an AUC, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of 0.722, 76.19 %, and 69.70 %, respectively. The diagnostic model included three miRNAs (miR-28-5p, miR-489, and miR-671-3p) with an AUC, PPV, and NPV of 0.841, 85.71 % and 83.33 %, respectively. Our results show that circulating miRNAs (miR-26b and miR-374a, miR-28-5p, miR-489 and miR-671-3p) may serve as biomarkers for the prediction and diagnosis of grades II-IV aGVHD.

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.

PubMed

Li, Feng; Nitteranon, Viriya; Tang, Xiaozhen; Liang, Jin; Zhang, Guodong; Parkin, Kirk L; Hu, Qiuhui

2012-11-15

Hexahydrocurcumin, 1-dehydro-[6]-gingerdione, 6-dehydroshogaol and 6-shogaol were evaluated for their antioxidant and anti-inflammatory activities in the present study. The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7μM and 6-shogaol of 7μM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14μM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-dehydro-[6]-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion. These results contribute to our theoretical understanding of the potential beneficial effects of consuming ginger as a food and/or dietary supplement. Copyright © 2012 Elsevier Ltd. All rights reserved.

Sport Injuries Sustained by Athletes with Disability: A Systematic Review.

PubMed

Weiler, Richard; Van Mechelen, Willem; Fuller, Colin; Verhagen, Evert

2016-08-01

Fifteen percent of the world's population live with disability, and many of these individuals choose to play sport. There are barriers to sport participation for athletes with disability and sports injury can greatly impact on daily life, which makes sports injury prevention additionally important. The purpose of this review is to systematically review the definitions, methodologies and injury rates in disability sport, which should assist future identification of risk factors and development of injury prevention strategies. A secondary aim is to highlight the most pressing issues for improvement of the quality of injury epidemiology research for disability sport. A search of NICE, AMED, British Nursing Index, CINAHL, EMBASE and Medline was conducted to identify all publications up to 16 June 2015. Of 489 potentially relevant articles and reference searching, a total of 15 studies were included. Wide study sample heterogeneity prevented data pooling and meta-analysis. Results demonstrated an evolving field of epidemiology, but with wide differences in sports injury definition and with studies focused on short competitions. Background data were generally sparse; there was minimal exposure analysis, and no analysis of injury severity, all of which made comparison of injury risk and injury severity difficult. There is an urgent need for consensus on sports injury definition and methodology in disability sports. The quality of studies is variable, with inconsistent sports injury definitions, methodologies and injury rates, which prevents comparison, conclusions and development of injury prevention strategies. The authors highlight the most pressing issues for improvement of the quality in injury epidemiology research for disability sport.

Association of GABA(B)R1 receptor gene polymorphism with obstructive sleep apnea syndrome.

PubMed

Bayazit, Yildirim A; Yilmaz, Metin; Kokturk, Oguz; Erdal, M Emin; Ciftci, Tansu; Gokdogan, Tuba; Kemaloglu, Yusuf; Ileri, Fikret

2007-01-01

GABA(B)R (gamma-amino butyric acid B receptor)-mediated neurotransmission has been implicated in the pathophysiology of a variety of neuropsychiatric disorders. GABA(B)R1 gene variants were identified by single-strand conformation analysis. The nucleotide exchanges cause a substitution of alanine to valine in exon 1a1 (Ala20Val), a substitution of glycine to serine in exon 7 (Gly489Ser) and a silent C to G nucleotide exchange encoding the amino acid phenylalanine in exon 11 (Phe658Phe). The significance of GABA(B)R1a gene polymorphism in obstructive sleep apnea syndrome (OSAS) as well as the association of these polymorphisms with the polysomnography findings in OSAS patients are not known. In this study, we aimed to assess the significance of 3 different GABA(B)R1 gene polymorphisms (Ala20Val, Gly489Ser and Phe658Phe) in OSAS. Seventy-five patients (23 female and 52 male) with OSAS and 99 healthy volunteers (51 female, 48 male) were included in the study to assess Ala20Val, Gly489Ser and Phe658Phe polymorphisms of the GABA(B)R1 gene. For the Ala20Val variants, there was no significant difference between the genotypes and allele frequencies of the patients and controls, nor between both genders (p > 0.05). For Phe658Phe polymorphism, there was no significant difference between genotypes and allele frequencies of the patients and controls (p > 0.05). However, the C/C genotype was overrepresented and the T/C genotype was less frequent in male than female patients (p = 0.03). The C/C genotype was overrepresented and the T/C genotype was less frequent in male patients than male controls (p = 0.01). For GABA(B)R1-Gly489Ser polymorphism, all of the patients and controls had G/G genotype. The apnea arousal index scores of the male patients with C/C genotype were significantly higher than in the patients with C/T genotype (p = 0.01). The percent total sleep time in non-REM 1 scores of the male patients with T/T genotype were significantly higher than in the patients with T/C genotype (p = 0.021). The percent total sleep time in non-REM 2 scores of the female patients with C/C genotype were significantly higher than in the patients with C/T genotype (p = 0.006). The Ala20Val polymorphism of the GABA(B)R1 gene may be associated with OSAS, whereas Gly489Ser polymorphism does not seem to be involved in OSAS. The C/C variant of the Phe658Phe polymorphism GABA(B)R1 gene seems associated with the occurrence of OSAS and is also associated with some sleep related parameters (apnea arousal index and percent total sleep time in non-REM) recorded by polysomnography. Copyright (c) 2007 S. Karger AG, Basel.

Effects of Cisplatin-Loaded Niosomal Nanoparticleson BT-20 Human Breast Carcinoma Cells

PubMed Central

Kanaani, Leila; javadi, Iraj; Ebrahimifar, Meysam; shahmabadi, Hasan Ebrahimi; Khiyavi, Azim Akbarzadeh; Mehrdiba, Torkan

2017-01-01

Breast cancer is the fifth most common cause of death among women worldwide. Resistance to cisplatin is a main challenge in its treatment. Our present aim was to prepare nanoniosomated cisplatin and examine its efficacy in vitro using the BT-20 cell line. Niosome nanoparticles containing cisplatin were prepared by reverse-phase evaporation and characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), spectrophotometry and MTT assay. The size and zeta potential of the nanodrug were estimated as 489.3 ± 23.66 nm and 23.4 ± 2.1 mV, respectively. Drug encapsuies confirmed appropriate retention of particles. Nanoparticles also increased the cytotoxic effects of cisplatin by 1.5 times compared to the standard drug. Findings of our study suggest that niosome nanoparticles are good carriers for cisplatin delivery to breast cancer cells. PMID:28345332

42 CFR 489.54 - Termination by the OIG.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., any false statement or representation of a material fact for use in an application or request for... lack of knowledge are set forth in §§ 405.330 through 405.334 of this chapter.) (b) Notice of...

42 CFR 489.54 - Termination by the OIG.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., any false statement or representation of a material fact for use in an application or request for... lack of knowledge are set forth in §§ 405.330 through 405.334 of this chapter.) (b) Notice of...

47 CFR 17.53 - Lighting equipment and paint.

Code of Federal Regulations, 2014 CFR

2014-10-01

... orange, enamel TT-E-489 1 (Color No. 12197, FS-595). Aviation red obstruction light—color MIL-C-25050 2... specification can be obtained from the Specification Activity, Building 197, Room 301, Naval Weapons Plant, 1st...

47 CFR 17.53 - Lighting equipment and paint.

Code of Federal Regulations, 2012 CFR

2012-10-01

... orange, enamel TT-E-489 1 (Color No. 12197, FS-595). Aviation red obstruction light—color MIL-C-25050 2... specification can be obtained from the Specification Activity, Building 197, Room 301, Naval Weapons Plant, 1st...

47 CFR 17.53 - Lighting equipment and paint.

Code of Federal Regulations, 2013 CFR

2013-10-01

... orange, enamel TT-E-489 1 (Color No. 12197, FS-595). Aviation red obstruction light—color MIL-C-25050 2... specification can be obtained from the Specification Activity, Building 197, Room 301, Naval Weapons Plant, 1st...

47 CFR 17.53 - Lighting equipment and paint.

Code of Federal Regulations, 2010 CFR

2010-10-01

... orange, enamel TT-E-489 1 (Color No. 12197, FS-595). Aviation red obstruction light—color MIL-C-25050 2... specification can be obtained from the Specification Activity, Building 197, Room 301, Naval Weapons Plant, 1st...

High-sensitivity DPSK receiver for high-bandwidth free-space optical communication links.

PubMed

Juarez, Juan C; Young, David W; Sluz, Joseph E; Stotts, Larry B

2011-05-23

A high-sensitivity modem and high-dynamic range optical automatic gain controller (OAGC) have been developed to provide maximum link margin and to overcome the dynamic nature of free-space optical links. A sensitivity of -48.9 dBm (10 photons per bit) at 10 Gbps was achieved employing a return-to-zero differential phase shift keying based modem and a commercial Reed-Solomon forward error correction system. Low-noise optical gain was provided by an OAGC with a noise figure of 4.1 dB (including system required input loses) and a dynamic range of greater than 60 dB.

Habitat impacts of offshore drilling, eastern Gulf of Mexico

USGS Publications Warehouse

Shinn, Eugene A.; Lidz, Barbara H.; Reich, Christopher D.

1994-01-01

In this survey six offshore exploratory drill sites in a variety of environments and water depths were examined using a small research submersible. Sites varied from locations off northwest Florida to as far west as offshore Alabama. Water depths ranged from 21 m (70 ft) to 149 m (489 ft), and bottom sediments ranged from carbonate mud to Shelly quartz sand and silt to hard limestone. The age of the sites (the time between cessation of drilling activities and our observations) ranged from 15 months to 17 years . In a previous MMS-funded study, Shinn et al. (1989) and Dustan et al . (1991) examined eight sites off South Florida, where the age of the sites ranged from 2 to 29 years. The study documented repeatedly variability of impact from site to site . In the present study, we note a similar wide divergence of impacts . Using the concentration of barium (the major component of drill mud), cuttings, and trace metals as a basis, we found that time is the single most important factor determining the nature of habitat recovery. Older sites, particularly the 17-year-old site, were relatively pristine. At a 7-year-old site, two hurricanes did far more damage than drilling . At other sites, we documented a significant amount of discarded debris, and at two 5-year-old sites, large concentrations of barium and cuttings. Impacts, such as the extent of debris and cuttings, affected the bottom ranging in area from almost negligible (17-year-old site) to as much as 3 acres (4-year-old site) . As suspected, those sites with the most debris and/or open boreholes attracted the most abundant and diverse fish fauna.

Lake-level stratigraphy and geochronology revisited at Lago (Lake) Cardiel, Argentina, and changes in the Southern Hemispheric Westerlies over the last 25 ka

NASA Astrophysics Data System (ADS)

Quade, J.; Kaplan, M. R.

2017-12-01

Paleoshorelines around Lago (Lake) Cardiel in southern Argentina (S48.9°, W71.3°; ∼275 m) record substantial changes in lake area over the past 25 ka. Our results combined with previous research show that during the last glacial maximum (or LGM, 23-21 ka), the lake stood at near modern levels, but had nearly dried up by ∼13 ka. Between 11.3 and 10.1 ka the lake reached its highest point (+54-58 m) and greatest extent in at least the last 40 ka. Lake levels dropped thereafter and experienced two lower-lake periods: 8.5-7.5 ka and 5-3.3 ka; and two higher-lake periods: 7.4-6 and ∼5.2 ka. In the last 3.5 ka, the lake has remained generally near or slightly above its present level. The depth and surface area of Lago Cardiel are controlled mainly by precipitation onto the lake and surrounding catchment, air and water temperature, and wind-speed related to local strength of the Southern Hemispheric Westerlies (SHW). Our lake-level reconstruction combined with evidence from other studies suggest that on average the core of the SHW was located well to the north (<45°S) of the Cardiel basin during the deep lake phase associated with the LGM, and was well to the south (>55°S?) during the hydrologic maximum of Cardiel in the early Holocene. The lower phases of the lake at 20.0-11.5, 8.5-7.5, and 5.0-3.3 ka generally correspond to cold conditions in other records, when we infer that the SHW were strongly focused around the latitudes of Cardiel at 49°S.

Bone health in long-term gastric cancer survivors: A prospective study of high-dose vitamin D supplementation using an easy administration scheme.

PubMed

Climent, Marta; Pera, Manuel; Aymar, Isabel; Ramón, José M; Grande, Luis; Nogués, Xavier

2018-07-01

Bone disease in long-term survivors after gastric cancer resection has received little research attention. This study aimed to investigate bone health after curative resection of gastric cancer and the consequences of high-dose vitamin D supplementation in patients with low levels of 25-(OH)-vitamin D. Disease-free patients at least 24 months after gastric cancer resection represented the study cohort. Serum markers of bone metabolism were assessed at baseline and at 3 and 12 months. Bone mineral density and presence of fractures were assessed by X-ray at baseline. Patients with 25-(OH)-vitamin D ≤30 ng/mL at baseline received 16,000 IU of vitamin D3 every 10 days during the 1-year follow-up. Forty patients were included in the study. Mean time from surgery was 48.9 (24-109) months. Vitamin D insufficiency and secondary hyperparathyroidism were observed in 38 and 20 patients, respectively. Densitometry showed osteoporosis in 14 women and seven men and prevalent fractures in 12 women and six men at baseline. After 3 months of vitamin D supplementation, 35 patients reached values of 25-(OH)-vitamin D over 30 ng/mL. After 12 months, 38 patients were in the normal range of 25-(OH)-vitamin D. At the same time, iPTH levels and markers of bone turnover (C-terminal cross-linked telopeptide of type-I collagen, serum concentrations of bone-specific alkaline phosphatase and osteocalcin) significantly decreased after vitamin D intervention. Oral administration of high doses of vitamin D is easily implemented and restored 25-(OH)-vitamin D and iPTH values, which are frequently disturbed after gastric cancer resection.

Comparisons of Mineralogy Between Cumulate Eucrites and Lunar Meteorites Possibly from the Farside Anorsothitic Crust

NASA Technical Reports Server (NTRS)

Takeda, H.; Yamaguchi, A.; Hiroi, T.; Nyquist, L. E.; Shih, C.-Y.; Ohtake, M.; Karouji, Y.; Kobayashi, S.

2011-01-01

Anorthosites composed of nearly pure anorthite (PAN) at many locations in the farside highlands have been observed by the Kaguya multiband imager and spectral profiler [1]. Mineralogical studies of lunar meteorites of the Dhofar 489 group [2,3] and Yamato (Y-) 86032 [4], all possibly from the farside highlands, showed some aspects of the farside crust. Nyquist et al. [5] performed Sm-Nd and Ar-Ar studies of pristine ferroan anorthosites (FANs) of the returned Apollo samples and of Dhofar 908 and 489, and discussed implications for lunar crustal history. Nyquist et al. [6] reported initial results of a combined mineralogical/chronological study of the Yamato (Y-) 980318 cumulate eucrite with a conventional Sm-Nd age of 4567 24 Ma and suggested that all eucrites, including cumulate eucrites, crystallized from parental magmas within a short interval following differentiation of their parent body, and most eucrites participated in an event or events in the time interval 4400- 4560 Ma in which many isotopic systems were partially reset. During the foregoing studies, we recognized that variations in mineralogy and chronology of lunar anorthosites are more complex than those of the crustal materials of the HED parent body. In this study, we compared the mineralogies and reflectance spectra of the cumulate eucrites, Y-980433 and 980318, to those of the Dhofar 307 lunar meteorite of the Dhofar 489 group [2]. Here we consider information from these samples to gain a better understanding of the feldspathic farside highlands and the Vesta-like body.

Application of chromosome microarray analysis in patients with unexplained developmental delay/intellectual disability in South China.

PubMed

Wang, Rongyue; Lei, Tingying; Fu, Fang; Li, Ru; Jing, Xiangyi; Yang, Xin; Liu, Juan; Li, Dongzhi; Liao, Can

2018-03-26

Chromosome microarray analysis (CMA) is currently the first-tier diagnostic assay for the evaluation of developmental delay (DD) and intellectual disability (ID) with unknown etiology. Here, we present our clinical experience in implementing whole-genome high-resolution single nucleotide polymorphism (SNP) arrays to investigate 489 patients with unexplained DD/ID in whom standard karyotyping analyses showed normal karyotypes. This study aimed to assess the usefulness of CMA for clinical diagnostic testing in the Chinese population. A total of 489 children were classified into three groups: isolated DD/ID (n = 358), DD/ID with epilepsy (n = 49), and DD/ID with other structural anomalies (n = 82). We identified 126 cases (25.8%, 126/489) of pathogenic copy number variants (CNVs) by CMA, including 89 (24.9%, 89/358) with isolated DD/ID, 13 (26.5%, 13/49) with DD/ID with epilepsy, and 24 (29.3%, 24/82) with DD/ID with other structural anomalies. Among the 126 cases of pathogenic CNVs, 79 cases were identified as microdeletion/microduplication syndromes, among which 76 cases were classified as common syndromes, and 3 cases were classified as rare syndromes, including 15q24 microdeletion syndrome, Xq28 microduplication syndrome and Lowe syndrome. Additionally, there were forty-seven cases of non-syndromic pathogenic CNVs. The ABAT, FTSJ1, DYNC1H1, and SETBP1 genes were identified as DD/ID candidate genes. Our findings suggest the necessity of CMA as a routine diagnostic test for unexplained DD/ID in South China. Copyright © 2018. Published by Elsevier B.V.

One-step facile hydrothermal synthesis of Fe2O3@LiCoO2 composite as excellent supercapacitor electrode materials

NASA Astrophysics Data System (ADS)

Gopi, Chandu V. V. Muralee; Somasekha, A.; Reddy, Araveeti Eswar; Kim, Soo-Kyoung; Kim, Hee-Je

2018-03-01

Herein, for the first time, we demonstrate the fabrication of Fe2O3@LiCoO2 hybrid nanostructures on Ni foam substrate by facile one-step hydrothermal technique. Morphological studies reveal that aggregated Fe2O3 nanoflakes anchored on the surface of sphere-like LiCoO2 nanoflakes. Electrochemical studies are used to examine the performance of the supercapacitor electrodes. The composite Fe2O3@LiCoO2 electrode exhibited excellent electrochemical performance than Fe2O3 and LiCoO2 electrodes, such as a low charge transfer resistance, a high specific capacitance of 489 F g-1 at 5 mA cm-2 and an enhanced capacity retention of 108% over 3000 cycles at 15 mA cm-2. The composite Fe2O3@LiCoO2 holds great promise for electrochemical applications due to well-defined hierarchical morphology, synergetic effect of Fe2O3 and LiCoO2, enhanced electrical conductivity, efficient electrolyte penetration and fast electron transfer.

Comparison of Removal Behavior of Two Biotrickling Filters under Transient Condition and Effect of pH on the Bacterial Communities

PubMed Central

Tu, Xiang; Li, Jianjun; Feng, Rongfang; Sun, Guoping; Guo, Jun

2016-01-01

Although biotrickling filters (BTFs) applied under acidic condition to remove H2S from waste gases have been reported, the removal behavior of the acidic BTF under transient condition which was normal in most industry processes, and corresponding bacterial community have not been thoroughly studied. In the present study, two BTFs were run under neutral (BTFn) and acidic (BTFa) conditions, respectively. The results revealed that the removal performance of BTFa under transient condition was superior to that of BTFn; the maximum H2S eliminating capacities (ECs) achieved by BTFa and BTFn were 489.9 g/m3 h and 443.6 g/m3 h, respectively. High-throughput sequencing suggested that pH was the critical factor and several other factors including nutrient and the inlet loadings also had roles in shaping bacterial community structure. Acidithiobacillus was the most abundant bacterial group. The results indicated that BTF acclimation under acidic condition may facilitate generating microbial community with high H2S-degrading capability. PMID:27196300

Fluorene-Based Conjugated Microporous Polymers: Preparation and Chemical Sensing Application.

PubMed

Zhang, Qiujing; Yu, Sen; Wang, Qian; Xiao, Qin; Yue, Yong; Ren, Shijie

2017-12-01

Conjugated microporous polymers (CMPs) with strong fluorescence are great candidates for optoelectronic applications such as photocatalysis and chemical sensing. A series of novel fluorene-based conjugated microporous polymers (FCMPs) with different electronic structures are prepared by Yamamoto coupling reactions using rationally designed monomers. The FCMPs show a high degree of microporosity, decent specific surface areas, and variable fluorescence. FCMP3, which possesses a triazine knot in the network, exhibits the highest specific surface area of 489 m 2 g -1 , the largest pore volume of 0.30 cm 3 g -1 , and the highest solid-state photoluminescence quantum yield of 11.46%. Chemical sensing performance of FCMPs is studied using a range of nitroaromatic compounds as the analytes. Among the FCMPs, FCMP3 exhibits the highest Stern-Volmer constants of 2541, 4708, and 5241 m -1 for the detection of nitrobenzene, 4-nitrotoluene, 2,4-dinitrotoluene, respectively, which are comparable to the detecting efficiency of the state-of-the-art CMP-based sensing agents. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Antioxidant and orofacial anti-nociceptive activities of the stem bark aqueous extract of Anadenanthera colubrina (Velloso) Brenan (Fabaceae).

PubMed

Damascena, N P; Souza, M T S; Almeida, A F; Cunha, R S; Damascena, N P; Curvello, R L; Lima, A C B; Almeida, E C V; Santos, C C S; Dias, A S; Paixão, M S; Souza, L M A; Quintans Júnior, L J; Estevam, C S; Araujo, B S

2014-01-01

The anti-nociceptive and antioxidant activities of the Anadenantheracolubrina stem bark aqueous extract (AEAC) were investigated. AEAC (30 μg/mL) reduced 94.8% of 2,2-diphenyl-1-picrylhydrazyl radical and prevented 64% (200 μg/mL) of lipid peroxidation caused by 2,2'-azobis(2-methylpropionamidine) dihydrochloride-induced peroxyl radicals. AEAC treatment (200 and 400 mg/kg) significantly (p < 0.001) reduced mice orofacial nociception in the first (61.4% and 62.6%, respectively) and second (48.9% and 61.9%, respectively) phases of the formalin test. Nociception caused by glutamate was significantly (p < 0.001) reduced by up to 79% at 400 mg/kg, while 56-60% of the nociceptive behaviour induced by capsaicin was significantly inhibited by AEAC (100-400 mg/kg). Mice treated with AEAC did not show changes in motor performance in the Rota-rod apparatus. It appears that AEAC is of pharmacological importance in treating pain due to its anti-nociceptive effects, which were shown to be mediated by central and peripheral mechanisms.

76 FR 71060 - Clarification of Duplication of Benefits Requirements Under the Stafford Act for Community...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... Hospitals, as applicable). State grantees are subject to 24 CFR 570.489(d), which requires that states shall..., SBA, other local, state, or Federal programs, and private or nonprofit charity organizations. See...

Publications - GMC 191 | Alaska Division of Geological & Geophysical

Science.gov Websites

(3,489'-3,511') from the Union Oil Co. of California Ruby State #1 well Authors: Unknown Publication Date the Union Oil Co. of California Ruby State #1 well: Alaska Division of Geological & Geophysical

34 CFR 460.2 - What programs are authorized by the Adult Education Act?

Code of Federal Regulations, 2010 CFR

2010-07-01

... and Policy Studies Program (34 CFR part 438). (k) Functional Literacy for State and Local Prisoners Program (34 CFR part 489). (l) Life Skills for State and Local Prisoners Program (34 CFR part 490...

Fate of Escherichia coli O157:H7 in mechanically tenderized beef prime rib following searing, cooking, and holding under commercial conditions.

PubMed

Porto-Fett, Anna C S; Shoyer, Bradley A; Thippareddi, Harshavardhan; Luchansky, John B

2013-03-01

We evaluated the effect of commercial times and temperatures for searing, cooking, and holding on the destruction of Escherichia coli O157:H7 (ECOH) within mechanically tenderized prime rib. Boneless beef ribeye was inoculated on the fat side with ca. 5.7 log CFU/g of a five-strain cocktail of ECOH and then passed once through a mechanical tenderizer with the fat side facing upward. The inoculated and tenderized prime rib was seared by broiling at 260°C for 15 min in a conventional oven and then cooked in a commercial convection oven at 121.1°C to internal temperatures of 37.8, 48.9, 60.0, and 71.1°C before being placed in a commercial holding oven maintained at 60.0°C for up to 8 h. After searing, ECOH levels decreased by ca. 1.0 log CFU/g. Following cooking to internal temperatures of 37.8 to 71.1°C, pathogen levels decreased by an additional ca. 2.7 to 4.0 log CFU/g. After cooking to 37.8, 48.9, or 60.0°C and then warm holding at 60.0°C for 2 h, pathogen levels increased by ca. 0.2 to 0.7 log CFU/g. However, for prime rib cooked to 37.8°C, pathogen levels remained relatively unchanged over the next 6 h of warm holding, whereas for those cooked to 48.9 or 60.0°C pathogen levels decreased by ca. 0.3 to 0.7 log CFU/g over the next 6 h of warm holding. In contrast, after cooking prime rib to 71.1°C and holding for up to 8 h at 60.0°C, ECOH levels decreased by an additional ca. 0.5 log CFU/g. Our results demonstrated that to achieve a 5.0-log reduction of ECOH in blade tenderized prime rib, it would be necessary to sear at 260°C for 15 min, cook prime rib to internal temperatures of 48.9, 60.0, or 71.1°C, and then hold at 60.0°C for at least 8 h.

Mentoring and Training of Cancer-Related Health Disparities Researchers Committed to Community-Based Participatory Research.

PubMed

Felder, Tisha M; Braun, Kathryn L; Brandt, Heather M; Khan, Samira; Tanjasiri, Sora; Friedman, Daniela B; Armstead, Cheryl A; Okuyemi, Kolawole S; Hébert, James R

2015-01-01

The National Cancer Institute's (NCI) Community Networks Program Centers (CNPCs) provide community-based participatory research (CBPR)-oriented mentoring and training to prepare early-stage/midcareer investigators and student trainees (trainees) in disparities reduction. This paper describes the academic, mentoring, training, and work-life balance experiences of CNPC-affiliated trainees. We used a collaborative and iterative process to develop a 57-item, web-based questionnaire completed by trainees from the 23 CNPCs between August 2012 and February 2013. Their CNPC mentors completed a 47-item questionnaire. Descriptive statistics were calculated. The final analytic sample included 189 of 269 individuals (70%) identified as active participants in CNPC research or training/mentoring. Mentors (n=45) were mostly non-Hispanic White (77.8%) and 48.9% were male. Mentors published a median of 6 (interquartile range [IQR], 3-12) first-authored and 15 (IQR, 6-25) senior authored manuscripts, and secured 15 (IQR, 11-29) grants from the National Institutes of Health (NIH) and other sources in the previous 5 years. Most trainees (n=144) were female (79.2%), 43.7% were underrepresented racial/ethnic minorities, and 36.8% were first-generation college graduates. Over the previous 5 years, trainees reported a median of 4 (IQR, 1-6) publications as first author and 4 (IQR, 2-8) as co-author; 27.1% reported having one or more NIH R01s. Trainees reported satisfaction with their CNPC mentor (79.1%) and confidence in demonstrating most CBPR competencies. The CNPC training program consists of a scientifically productive pool of mentors and trainees. Trainees reported rates of scholarly productivity comparable to other national training programs and provided insights into relationships with mentors, academic pressures, and professional-personal life balance.

Health-Related Quality-of-Life Analysis From KEYNOTE-045: A Phase III Study of Pembrolizumab Versus Chemotherapy for Previously Treated Advanced Urothelial Cancer.

PubMed

Vaughn, David J; Bellmunt, Joaquim; Fradet, Yves; Lee, Jae Lyun; Fong, Lawrence; Vogelzang, Nicholas J; Climent, Miguel A; Petrylak, Daniel P; Choueiri, Toni K; Necchi, Andrea; Gerritsen, Winald; Gurney, Howard; Quinn, David I; Culine, Stephane; Sternberg, Cora N; Mai, Yabing; Li, Haojie; Perini, Rodolfo F; Bajorin, Dean F; de Wit, Ronald

2018-03-28

Purpose In the phase III KEYNOTE-045 study ( ClinicalTrials.gov identifier: NCT02256436), pembrolizumab significantly prolonged overall survival compared with investigator's choice of chemotherapy in patients with previously treated advanced urothelial cancer. Here, we report the results of health-related quality-of-life (HRQoL) analyses from the KEYNOTE-045 trial. Patients and Methods Patients were randomly assigned 1:1 to pembrolizumab 200 mg or investigator's choice of docetaxel 75 mg/m 2 , paclitaxel 175 mg/m 2 , or vinflunine 320 mg/m 2 administered intravenously every 3 weeks. Key prespecified HRQoL analyses were time to deterioration (TTD) and mean change from baseline to week 15 in European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 global health status/quality-of-life score. Results Of 542 patients who were randomly assigned, 519 were included in HRQoL analyses (pembrolizumab, n = 266; chemotherapy, n = 253). HRQoL compliance was > 95% at baseline and approximately 88% at week 15 for both groups. Pembrolizumab prolonged TTD in global health status/quality-of-life score compared with chemotherapy (median, 3.5 months v 2.3 months; hazard ratio, 0.72; nominal one-sided P = .004). Mean (95% CI) change from baseline to week 15 in global health status/quality-of-life score was 0.69 (-2.40 to 3.77) with pembrolizumab and -8.36 (-11.84 to -4.89) with chemotherapy (mean difference, 9.05 points; 95% CI, 4.61 to 13.50; nominal two-sided P < .001). Conclusion Pembrolizumab prolonged TTD in HRQoL compared with chemotherapy. Patients who were treated with pembrolizumab had stable or improved global health status/quality of life, whereas those who were treated with investigator's choice of chemotherapy experienced declines in global health status/quality of life. Combined with efficacy and safety outcomes, these data support pembrolizumab as standard of care for patients with platinum-refractory advanced urothelial cancer.

Presence of faecal coliforms and selected heavy metals in ice cubes from food outlets in Taman Universiti, Johor Bahru, Malaysia.

PubMed

Mahat, N A; Meor Ahmad, Z; Abdul Wahab, R

2015-09-01

Consumption of iced beverages is common in Malaysia although specific research focusing on its safety parameters such as presence of faecal coliforms and heavy metal elements remains scarce. A study conducted in Kelantan indicated that faecal coliforms were detected in the majority of the ice cube samples analyzed, largely attributable to improper handling. Hence, it was found pertinent to conduct similar study in other parts of the country such as Johor Bahru if the similar pattern prevailed. Therefore, this present cross sectional study which randomly sampled ice cubes from 30 permanent food outlets in Taman Universiti, Johor Bahru for detecting contamination by faecal coliforms and selected heavy metal elements (lead, copper, manganese and zinc) acquires significance. Faecal coliforms were detected in 11 (36.67%) of the samples, ranging between 1 CFU/100 mL to > 50 CFU/100 mL; two of the samples were grossly contaminated (>50 CFU/100 mL). Interestingly, while positive detection of lead was observed in 29 of the 30 ice cube samples (mean: 0.511±0.105 ppm; range: 0.489-0.674 ppm), copper, manganese and zinc were not detected. In addition, analysis on commercially bottled mineral water as well as in tap water samples did not detect such contaminations. Therefore, it appears that (1) contamination of faecal coliforms in ice cubes in food outlets in Malaysia may not be sporadic in pattern but rather prevalent and (2) the source of water used for manufacturing the ice cubes that contained significant amount of lead would suggest that (3) it was neither originated from the treated tap water supply nor bottled mineral water or (4) perhaps contaminated during manufacturing process. Further studies exploring the source of water used for manufacturing these ice cubes as well as the handling process among food operators deserve consideration.

Association of premenstrual syndrome and premenstrual dysphoric disorder with bulimia nervosa and binge-eating disorder in a nationally representative epidemiological sample.

PubMed

Nobles, Carrie J; Thomas, Jennifer J; Valentine, Sarah E; Gerber, Monica W; Vaewsorn, Adin S; Marques, Luana

2016-07-01

Bulimia nervosa (BN) and binge-eating disorder (BED) are associated with significant health impairment. Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) comprise both psychological (disturbances in mood and affect) and physiological (bloating and changes in appetite) symptoms that may trigger binge-eating and/or purging. Female participants were drawn from the Collaborative Psychiatric Epidemiological Surveys, conducted from 2001 to 2003. Weighted multivariable logistic regression modeled the association between lifetime PMS and PMDD and lifetime odds of BN or BED. Among 8,694 participants, 133 (1.0%) had BN and 185 (1.8%) BED. Additionally, 366 (4.2%) had PMDD and 3,489 (42.4%) had PMS. Prevalence of PMDD and PMS were 17.4 and 55.4% among those with BN, 10.7 and 48.9% among those with BED and 3.4 and 59.1% among those with subthreshold BED. After adjustment for age, race/ethnicity, income, education, body mass index, age at menarche, birth control use, and comorbid mental health conditions, PMDD was associated with seven times the odds of BN (OR 7.2, 95% CI 2.3, 22.4) and PMS with two times the odds of BN (OR 2.5, 95% CI 1.1, 5.7). Neither PMDD nor PMS were significantly associated with BED. Women with PMS and PMDD have a higher odds of BN, independent of comorbid mental health conditions. PMS and PMDD may be important comorbidities to BN to consider in clinical settings, and future research should investigate whether PMS and PMDD affect the onset and duration of bulimic symptoms as well as the potential for shared risk factors across disorders. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:641-650). © 2016 Wiley Periodicals, Inc.

Association of premenstrual syndrome and premenstrual dysphoric disorder with bulimia nervosa and binge-eating disorder in a nationally representative epidemiological sample

PubMed Central

Nobles, Carrie J.; Thomas, Jennifer J.; Valentine, Sarah E.; Gerber, Monica W.; Vaewsorn, Adin S.; Marques, Luana

2016-01-01

Objective Bulimia nervosa (BN) and binge eating disorder (BED) are associated with significant health impairment. Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) comprise both psychological (disturbances in mood and affect) and physiological (bloating and changes in appetite) symptoms that may trigger binge eating and/or purging. Method Female participants were drawn from the Collaborative Psychiatric Epidemiological Surveys, conducted from 2001–2003. Weighted multivariable logistic regression modeled the association between lifetime PMS and PMDD and lifetime odds of BN or BED. Results Among 8,694 participants, 133 (1.0%) had BN and 185 (1.8%) BED. Additionally, 366 (4.2%) had PMDD and 3,489 (42.4%) had PMS. Prevalence of PMDD and PMS were 17.4% and 55.4% among those with BN, 10.7% and 48.9% among those with BED and 3.4% and 59.1% among those with subthreshold BED. After adjustment for age, race/ethnicity, income, education, body mass index, age at menarche, birth control use and comorbid mental health conditions, PMDD was associated with 7-times the odds of BN (OR 7.2, 95% CI 2.3, 22.4) and PMS with 2-times the odds of BN (OR 2.5, 95% CI 1.1, 5.7). Neither PMDD nor PMS were significantly associated with BED. Discussion Women with PMS and PMDD have a higher odds of BN, independent of comorbid mental health conditions. PMS and PMDD may be important comorbidities to BN to consider in clinical settings, and future research should investigate whether PMS and PMDD affect the onset and duration of bulimic symptoms as well as the potential for shared risk factors across disorders. PMID:27206163

Emotional competence relating to perceived stress and burnout in Spanish teachers: a mediator model.

PubMed

Rey, Lourdes; Extremera, Natalio; Pena, Mario

2016-01-01

This study examined direct associations between emotional competence, perceived stress and burnout in 489 Spanish teachers. In addition, a model in which perceived stress mediated pathways linking emotional competence to teacher burnout symptoms was also examined. Results showed that emotional competence and stress were significantly correlated with teacher burnout symptoms in the expected direction. Moreover, mediational analysis indicated that perceived stress partly mediated the relationship between emotional competence and the three dimensions of burnout even when controlling for salient background characteristics. These findings suggest an underlying process by which high emotional competence may increase the capacity to cope with symptoms of burnout, by reducing the experience of stress. Implications of these findings for future research and for working with teachers to prevent burnout are discussed.

Emotional competence relating to perceived stress and burnout in Spanish teachers: a mediator model

PubMed Central

Extremera, Natalio

2016-01-01

This study examined direct associations between emotional competence, perceived stress and burnout in 489 Spanish teachers. In addition, a model in which perceived stress mediated pathways linking emotional competence to teacher burnout symptoms was also examined. Results showed that emotional competence and stress were significantly correlated with teacher burnout symptoms in the expected direction. Moreover, mediational analysis indicated that perceived stress partly mediated the relationship between emotional competence and the three dimensions of burnout even when controlling for salient background characteristics. These findings suggest an underlying process by which high emotional competence may increase the capacity to cope with symptoms of burnout, by reducing the experience of stress. Implications of these findings for future research and for working with teachers to prevent burnout are discussed. PMID:27280077

The effect of poverty-influenced, food-related consumer behaviors on obesity: An analysis of the NHANES flexible consumer behavioral module.

PubMed

O'Dare Wilson, Kellie

2017-01-01

Despite extensive research investigating obesity, the problem continues to increase, particularly in poor, minority, and under-resourced communities. However, the literature continues to demonstrate many obesity-predicating variables are outside of personal volitional control, such as food-related consumer behaviors, which are strongly influenced by income and environment. This cross-sectional study (n = 5,109) employed secondary data analysis to quantitatively examine the effect of food-related consumer variables on obesity while controlling for covariates. Participants answered questions regarding money spent on food, time preparing meals, number of meals eaten at home and away from home, and types of food products consumed (frozen/fast foods, sodas, salty snacks, etc.) In this study, 48.9% of respondents were either overweight or obese. No significant differences were noted between the contextual variables examined and BMI scores. However, given the sample's limitations illuminated in the study, further research regarding the relationship between obesity and poverty-influenced, food-related consumer behaviors is warranted.

Comparison of pleural pressure measuring instruments.

PubMed

Lee, Hans J; Yarmus, Lonny; Kidd, David; Ortiz, Ricardo; Akulian, Jason; Gilbert, Christopher; Hughes, Andrew; Thompson, Richard E; Arias, Sixto; Feller-Kopman, David

2014-10-01

The objective of this study was to compare the accuracy of a handheld digital manometer (DM) and U-tube (UT) manometer with an electronic transducer (ET) manometer during thoracentesis. Thirty-three consecutive patients undergoing thoracentesis were enrolled in the study. Pleural pressure (Ppl) measurements were made using a handheld DM (Compass; Mirador Biomedical), a UT water manometer, and an ET (reference instrument). End-expiratory Ppl was recorded after catheter insertion, after each aspiration of 240 mL, and prior to catheter removal. Volume of fluid removed, symptoms during thoracentesis, pleural elastance, and pleural fluid chemistry were also evaluated. A total of 594 Ppl measurements were made in 30 patients during their thoracenteses. There was a strong linear correlation coefficient between elastance for the DM and ET (r = 0.9582, P < .001). Correlation was poor between the UT and ET (r = 0.0448, P = .84). Among the 15 patients who developed cough, recorded ET pressures ranged from -9 to +9 cm H2O at the time of symptom development, with a mean (SD) of -2.93 (4.89) cm H2O. ET and DM measurements among those patients with cough had a low correlation between these measurements (R2 = 0.104, P = .24). Nine patients developed chest discomfort and had ET pressures that ranged from -26 to +6 cm H2O, with a mean (SD) of -7.89 (9.97) cm H2O. The handheld DM provided a valid and easy-to-use method to measure Ppl during thoracentesis. Future studies are needed to investigate its usefulness in predicting clinically meaningful outcomes.

75 FR 39734 - Health Services Research and Development Service Merit Review Board; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-12

... from 8 a.m. to 5 p.m. On September 2, the subcommittee on Health Services Research 7 for Pilot Proposal... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Merit Review Board... Advisory Committee Act) that a meeting of the Health Services Research and Development Service Merit Review...

An egg injection method for assessing early life stage mortality of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in rainbow trout, (Oncorhynchus mykiss)

USGS Publications Warehouse

Walker, M.K.; Hufnagle, L.C.; Clayton, M.K.; Peterson, R.E.

1992-01-01

To characterize the risk that polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) pose to salmonid early life stage survival, we developed a method to expose rainbow trout (Oncorhynchus mykiss) eggs to graded doses of PCDD, PCDF, and PCB congeners, using 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a prototype. Rainbow trout eggs were injected 24–50 h post-fertilization with 0.2 μl of 50 mM phosphatidylcholine (PC) liposomes (control) or 0.2 μl of 5–7 graded doses of TCDD incorporated into 50 mM PC liposomes. Injection volume never exceeded 0.6% egg volume. Immediately following injection, the injection site was sealed with Super glue®, resulting in 92–97% of TCDD dose retained by the egg. Following both egg injection and waterborne egg exposure. TCDD toxicity in rainbow trout was manifested by half-hatching mortality but predominantly by sac fry mortality associated with hemorrhages, pericardial edema, and yolk sac edema. TCDD LD50s, following injection and waterborne exposure of rainbow trout eggs, were 421 (331–489) and 439 (346–519) pg TCDD/g egg (LD50, 95% fiducial limits), respectively. As in rainbow trout, TCDD toxicity in lake trout (Salvelinus namaycush) following the same two routes of exposure was manifested by half-hatching mortality but predominantly by sac fry mortality preceded by hemorrhages and yolk sac edema. LD50s, based on the dose of TCDD in lake trout eggs, were 47 (21–65) and 65 (60–71) pg/g following injection and waterborne exposure, respectively. The egg injection method is ideal for assessing the relationship between early life stage mortality in rainbow trout and graded egg doses of individual PCDD, PCDF, or PCB congeners.

75 FR 4062 - Peer Review Best Practices Workshop

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

...:15 a.m. Panel 2: Applied Research, Technology Development--NIST, ARPA-E, ONR, MIT 12:30 p.m. Lunch 1... Energy Efficiency and Renewable Energy (EERE) funds a diverse portfolio of research, development...-federal organizations have chosen to select research and development projects, and on ``best practices...

An ontology of and roadmap for mHealth research.

PubMed

Cameron, Joshua D; Ramaprasad, Arkalgud; Syn, Thant

2017-04-01

Mobile health or mHealth research has been growing exponentially in recent years. However, the research on mHealth has been ad-hoc and selective without a clear definition of the mHealth domain. Without a roadmap for research we may not realize the full potential of mHealth. In this paper, we present an ontological framework to define the mHealth domain and illuminate a roadmap. We present an ontology of mHealth. The ontology is developed by systematically deconstructing the domain into its primary dimensions and elements. We map the extent research on mHealth in 2014 onto the ontology and highlight the bright, light, and blind/blank spots which represent the emphasis of mHealth research. The emphases of mHealth research in 2014 are very uneven. There are a few bright spots and many light spots. The research predominantly focuses on individuals' use of mobile devices and applications to capture or obtain health-related data mostly to improve quality of care through mobile intervention. We argue that the emphases can be balanced in the roadmap for mHealth research. The ontological mapping plays an integral role in developing and maintaining the roadmap which can be updated periodically to continuously assess and guide mHealth research. Copyright © 2017 Elsevier B.V. All rights reserved.

Mexico's Program for Science and Technology, 1978 to 1982.

ERIC Educational Resources Information Center

Flores, Edmundo

1979-01-01

Describes briefly the National Council for Science and Technology (CONACYT) of Mexico, and outlines Mexico's Program for Science and Technology which includes 2,489 projects in basic and applied sciences at a cost of $260 million from 1978 to 1982. (HM)

42 CFR 489.53 - Termination by CMS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER APPROVAL Termination of Agreement and... is attributable to that provider: (1) It is not complying with the provisions of title XVIII and the...

Enhanced photovoltaic performance of quantum dot-sensitized solar cells with a progressive reduction of recombination using Cu-doped CdS quantum dots

NASA Astrophysics Data System (ADS)

Muthalif, Mohammed Panthakkal Abdul; Lee, Young-Seok; Sunesh, Chozhidakath Damodharan; Kim, Hee-Je; Choe, Youngson

2017-02-01

In this article, we have systematically probed the effect of Cu-doping in CdS quantum dots (QDs) to enhance the photovoltaic performance of the quantum dot-sensitized solar cells (QDSSCs). The Cu-doped CdS photoanodes were prepared by successive ionic layer adsorption and reaction (SILAR) method and the corresponding cell devices were fabricated using CuS counter electrodes with a polysulfide electrolyte. The photovoltaic performance results demonstrate that 3 mM Cu-doped CdS QDs based QDSSCs exhibit the efficiency (η) of 3% including JSC = 9.40 mA cm-2, VOC = 0.637 V, FF = 0.501, which are higher than those with bare CdS (η = 2.05%, JSC = 7.12 mA cm-2, VOC = 0.588 V, FF = 0.489). The structural, topographical and optical properties of the thin films have been studied with the help of X-ray diffraction pattern (XRD), atomic force microscopy (AFM) and UV-vis spectrophotometer. Electrochemical impedance spectroscopy (EIS) and open circuit voltage decay (OCVD) measurements indicate that Cu-dopant can inhibit the charge recombination at the photoanode/electrolyte interface and extend the lifetime of electrons. These results reveal that incorporation of copper metal in CdS QDs is a simple and effective method to improve the photovoltaic properties of QDSSCs.

Effective conversion of maize straw wastes into bio-hydrogen by two-stage process integrating H2 fermentation and MECs.

PubMed

Li, Yan-Hong; Bai, Yan-Xia; Pan, Chun-Mei; Li, Wei-Wei; Zheng, Hui-Qin; Zhang, Jing-Nan; Fan, Yao-Ting; Hou, Hong-Wei

2015-12-01

The enhanced H2 production from maize straw had been achieved through the two-stage process of integrating H2 fermentation and microbial electrolysis cells (MECs) in the present work. Several key parameters affecting hydrolysis of maize straw through subcritical H2O were optimized by orthogonal design for saccharification of maize straw followed by H2 production through H2 fermentation. The maximum reducing sugar (RS) content of maize straw reached 469.7 mg/g-TS under the optimal hydrolysis condition with subcritical H2O combining with dilute HCl of 0.3% at 230 °C. The maximum H2 yield, H2 production rate, and H2 content was 115.1 mL/g-TVS, 2.6 mL/g-TVS/h, and 48.9% by H2 fermentation, respectively. In addition, the effluent from H2 fermentation was used as feedstock of MECs for additional H2 production. The maximum H2 yield of 1060 mL/g-COD appeared at an applied voltage of 0.8 V, and total COD removal reached about 35%. The overall H2 yield from maize straw reached 318.5 mL/g-TVS through two-stage processes. The structural characterization of maize straw was also carefully investigated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) spectra.

Accuracy of Blood Loss Measurement during Cesarean Delivery.

PubMed

Doctorvaladan, Sahar V; Jelks, Andrea T; Hsieh, Eric W; Thurer, Robert L; Zakowski, Mark I; Lagrew, David C

2017-04-01

Objective  This study aims to compare the accuracy of visual, quantitative gravimetric, and colorimetric methods used to determine blood loss during cesarean delivery procedures employing a hemoglobin extraction assay as the reference standard. Study Design  In 50 patients having cesarean deliveries blood loss determined by assays of hemoglobin content on surgical sponges and in suction canisters was compared with obstetricians' visual estimates, a quantitative gravimetric method, and the blood loss determined by a novel colorimetric system. Agreement between the reference assay and other measures was evaluated by the Bland-Altman method. Results  Compared with the blood loss measured by the reference assay (470 ± 296 mL), the colorimetric system (572 ± 334 mL) was more accurate than either visual estimation (928 ± 261 mL) or gravimetric measurement (822 ± 489 mL). The correlation between the assay method and the colorimetric system was more predictive (standardized coefficient = 0.951, adjusted R 2  = 0.902) than either visual estimation (standardized coefficient = 0.700, adjusted R 2  = 00.479) or the gravimetric determination (standardized coefficient = 0.564, adjusted R 2  = 0.304). Conclusion  During cesarean delivery, measuring blood loss using colorimetric image analysis is superior to visual estimation and a gravimetric method. Implementation of colorimetric analysis may enhance the ability of management protocols to improve clinical outcomes.

Accuracy of Blood Loss Measurement during Cesarean Delivery

PubMed Central

Doctorvaladan, Sahar V.; Jelks, Andrea T.; Hsieh, Eric W.; Thurer, Robert L.; Zakowski, Mark I.; Lagrew, David C.

2017-01-01

Objective This study aims to compare the accuracy of visual, quantitative gravimetric, and colorimetric methods used to determine blood loss during cesarean delivery procedures employing a hemoglobin extraction assay as the reference standard. Study Design In 50 patients having cesarean deliveries blood loss determined by assays of hemoglobin content on surgical sponges and in suction canisters was compared with obstetricians' visual estimates, a quantitative gravimetric method, and the blood loss determined by a novel colorimetric system. Agreement between the reference assay and other measures was evaluated by the Bland–Altman method. Results Compared with the blood loss measured by the reference assay (470 ± 296 mL), the colorimetric system (572 ± 334 mL) was more accurate than either visual estimation (928 ± 261 mL) or gravimetric measurement (822 ± 489 mL). The correlation between the assay method and the colorimetric system was more predictive (standardized coefficient = 0.951, adjusted R2 = 0.902) than either visual estimation (standardized coefficient = 0.700, adjusted R2 = 00.479) or the gravimetric determination (standardized coefficient = 0.564, adjusted R2 = 0.304). Conclusion During cesarean delivery, measuring blood loss using colorimetric image analysis is superior to visual estimation and a gravimetric method. Implementation of colorimetric analysis may enhance the ability of management protocols to improve clinical outcomes. PMID:28497007

Genetic basis of Spodoptera frugiperda (Lepidoptera: Noctuidae) resistance to the chitin synthesis inhibitor lufenuron.

PubMed

do Nascimento, Antonio Rogério Bezerra; Farias, Juliano Ricardo; Bernardi, Daniel; Horikoshi, Renato Jun; Omoto, Celso

2016-04-01

An understanding of the genetic basis of insect resistance to insecticides is important for the establishment of insect resistance management (IRM) strategies. In this study we evaluated the inheritance pattern of resistance to the chitin synthesis inhibitor lufenuron in Spodoptera frugiperda. The LC50 values (95% CI) were 0.23 µg lufenuron mL(-1) water (ppm) (0.18-0.28) for the susceptible strain (SUS) and 210.6 µg mL(-1) (175.90-258.10) for the lufenuron-resistant strain (LUF-R), based on diet-overlay bioassay. The resistance ratio was ≈ 915-fold. The LC50 values for reciprocal crosses were 4.89 µg mL(-1) (3.79-5.97) for female LUF-R and male SUS and 5.74 µg mL(-1) (4.70-6.91) for female SUS and male LUF-R, indicating that the inheritance of S. frugiperda resistance to lufenuron is an autosomal, incompletely recessive trait. Backcrosses of the progeny of reciprocal crosses with the parental LUF-R showed a polygenic effect. The estimated minimum number of independent segregations was in the 11.02 range, indicating that resistance to lufenuron is associated with multiple genes in S. frugiperda. Based on genetic crosses, the inheritance pattern of lufenuron resistance in S. frugiperda was autosomal, incompletely recessive and polygenic. Implications of this finding to IRM are discussed in this paper. © 2015 Society of Chemical Industry.

High perceived stress is associated with unfavorable eating behavior in overweight and obese Finns of working age.

PubMed

Järvelä-Reijonen, Elina; Karhunen, Leila; Sairanen, Essi; Rantala, Sanni; Laitinen, Jaana; Puttonen, Sampsa; Peuhkuri, Katri; Hallikainen, Maarit; Juvonen, Kristiina; Myllymäki, Tero; Föhr, Tiina; Pihlajamäki, Jussi; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kolehmainen, Marjukka

2016-08-01

Stress-related eating may be a potential factor in the obesity epidemic. Rather little is known about how stress associates with eating behavior and food intake in overweight individuals in a free-living situation. Thus, the present study aims to investigate this question in psychologically distressed overweight and obese working-aged Finns. The study is a cross-sectional baseline analysis of a randomized controlled trial. Of the 339 study participants, those with all the needed data available (n = 297, 84% females) were included. The mean age was 48.9 y (SD = 7.6) and mean body mass index 31.3 kg/m(2) (SD = 3.0). Perceived stress and eating behavior were assessed by self-reported questionnaires Perceived Stress Scale (PSS), Intuitive Eating Scale, the Three-Factor Eating Questionnaire, Health and Taste Attitude Scales and ecSatter Inventory. Diet and alcohol consumption were assessed by 48-h dietary recall, Index of Diet Quality, and AUDIT-C. Individuals reporting most perceived stress (i.e. in the highest PSS tertile) had less intuitive eating, more uncontrolled eating, and more emotional eating compared to those reporting less perceived stress (p < 0.05). Moreover, individuals in the highest PSS tertile reported less cognitive restraint and less eating competence than those in the lowest tertile (p < 0.05). Intake of whole grain products was the lowest among those in the highest PSS tertile (p < 0.05). Otherwise the quality of diet and alcohol consumption did not differ among the PSS tertiles. In conclusion, high perceived stress was associated with the features of eating behavior that could in turn contribute to difficulties in weight management. Stress-related way of eating could thus form a potential risk factor for obesity. More research is needed to develop efficient methods for clinicians to assist in handling stress-related eating in the treatment of obese people. Copyright © 2016 Elsevier Ltd. All rights reserved.

Volatile Compounds with Characteristic Odor of Essential Oil from Magnolia obovata Leaves by Hydrodistillation and Solvent-assisted Flavor Evaporation.

PubMed

Miyazawa, Mitsuo; Nakashima, Yoshimi; Nakahashi, Hiroshi; Hara, Nobuyuki; Nakagawa, Hiroki; Usami, Atsushi; Chavasiri, Warinthorn

2015-01-01

The present study focuses on the volatile compounds with characteristic odor of essential oil from the leaves of Magnolia obovata by hydrodistillation (HD) and solvent-assisted flavor evaporation (SAFE) method. Eighty-seven compounds, representing 98.0% of the total oil, were identified using HD. The major compounds of HD oil were (E)-β-caryophyllene (23.7%), α-humulene (11.6%), geraniol (9.1%), and borneol (7.0%). In SAFE oil, fifty-eight compounds, representing 99.7% of the total oil, were identified. The main compounds of SAFE oil were (E)-β-caryophyllene (48.9%), α-humulene (15.7%), and bicyclogermacrene (4.2%). In this study, we newly identified eighty-five compounds of the oils from M. obovata leaves. These oils were also subjected to aroma evaluation by gas chromatography-olfactometry (GC-O) and aroma extract dilution analysis (AEDA). As a result, twenty-four (HD) and twenty-five (SAFE) aroma-active compounds were detected. (E)-β-Caryophyllene, α-humulene, linalool, geraniol, 1,8-cineole, and bicyclogermacrene were found to impart the characteristic odor of M. obovata leaves. These results imply that the oils of M. obovata leaves must be investigated further to clarify their potential application in the food and pharmaceutical industries.

The marketing plan and outcome indicators for recruiting and retaining parents in the HomeStyles randomized controlled trial.

PubMed

Byrd-Bredbenner, Carol; Delaney, Colleen; Martin-Biggers, Jennifer; Koenings, Mallory; Quick, Virginia

2017-11-15

Despite the critical importance of successful recruitment and retention to study integrity, reporting of recruitment and retention strategies along with factors associated with successful recruitment and retention of participants in health-related interventions remain rare, especially for health and obesity prevention programs. Thus, the purpose of this article is to retrospectively examine the recruitment and retention marketing plan used in the online HomeStyles randomized controlled trial (RCT) and discuss outcomes associated with completion of the intervention. The HomeStyles RCT is an online intervention developed to motivate parents of young children to gain the skills and self-confidence needed to shape home environments and lifestyles to be protective against childhood obesity. Using the seven Ps of services marketing (i.e., people, place, product, physical evidence, price, promotion, and process), a comprehensive and systematic plan for recruitment and retention was implemented and outcomes assessed. A total of 489 parents with a young child aged 2 to < 6 years were eligible to participate, a final capture rate of 33%. Only 23% of Hispanic participants chose to use the Spanish-language version of HomeStyles intervention materials, below the demand anticipated. However, Hispanic enrollment overall was substantially higher than the U.S. population proportion (i.e., 17%). The number of participants prematurely leaving the study was similar in both treatment groups, indicating attrition was not differential. Completers reported high satisfaction of HomeStyles, using a 1-5 scale (strongly disagree to strongly agree) on guide attractiveness, interestingness, and usefulness. Despite all the retention efforts, the average monthly recruitment accrual rate of ~ 33 eligible enrolled participants at baseline (i.e., 489 participants/15-month recruitment period), declined to ~ 18, 11, 9, and 8 remaining recruited participants/month at midpoint, post, follow-up, and long-term follow-up surveys, respectively. In general, survey completers were significantly more likely to be female and perceived their child's health status to be better, and they were significantly less likely to be restrictive of their child's food intake. The findings of the present study highlight the need for far-reaching, concentrated, and varied recruitment strategies; sufficient time in the research plan for recruitment and retention activities; and creative, tireless, flexible, persistent project staff for health-related interventions.

Amino acid residues 489-503 of dihydropyridine receptor (DHPR) β1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor.

PubMed

Eltit, Jose M; Franzini-Armstrong, Clara; Perez, Claudio F

2014-12-26

The β1a subunit is a cytoplasmic component of the dihydropyridine receptor (DHPR) complex that plays an essential role in skeletal muscle excitation-contraction (EC) coupling. Here we investigate the role of the C-terminal end of this auxiliary subunit in the functional and structural communication between the DHPR and the Ca(2+) release channel (RyR1). Progressive truncation of the β1a C terminus showed that deletion of amino acid residues Gln(489) to Trp(503) resulted in a loss of depolarization-induced Ca(2+) release, a severe reduction of L-type Ca(2+) currents, and a lack of tetrad formation as evaluated by freeze-fracture analysis. However, deletion of this domain did not affect expression/targeting or density (Qmax) of the DHPR-α1S subunit to the plasma membrane. Within this motif, triple alanine substitution of residues Leu(496), Leu(500), and Trp(503), which are thought to mediate direct β1a-RyR1 interactions, weakened EC coupling but did not replicate the truncated phenotype. Therefore, these data demonstrate that an amino acid segment encompassing sequence (489)QVQVLTSLRRNLSFW(503) of β1a contains critical determinant(s) for the physical link of DHPR and RyR1, further confirming a direct correspondence between DHPR positioning and DHPR/RyR functional interactions. In addition, our data strongly suggest that the motif Leu(496)-Leu(500)-Trp(503) within the β1a C-terminal tail plays a nonessential role in the bidirectional DHPR/RyR1 signaling that supports skeletal-type EC coupling. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Sm-Nd and Ar-Ar Studies of DHO 908 and 489: Implications for Lunar Crustal History

NASA Technical Reports Server (NTRS)

Nyquist, L. E.; Shih, C. Y.; Reese, Y. D.; Park, J.; Bogard, D. D.; Garrison, D. H.; Yamaguchi, A.

2011-01-01

It is widely assumed that ferroan anorthosites (FANs) formed as flotation cumulates on a global lunar magma ocean (LMO). A corollary is that all FANs are approximately contemporaneous and formed with the same initial Nd-143/Nd-144 ratio. Indeed, a whole rock isochron for selected FANs (and An93 anorthosite) yields an isochron age of 4.42 +/- 0.13 Ga and initial Nd-143/Nd-144, expressed in epsilon-units, of epsilon(sub Nd,CHUR) = 0.3+/-0.3 relative to the CHondritic Uniform Reservoir , or epsilon(sub Nd,HEDPB)=-0.6+/-0.3 relative to the HED Parent Body. These values are in good agreement with the age (T) = 4.47+/-0.07 Ga, and epsilon(sub Nd,HEDPB) =-0.6 +/- 0.5 for FAN 67075. We also have studied anorthositic clasts in the Dhofar 908 and 489 lunar highland meteorites containing clasts of magnesian anorthosites (MAN) with Mg# approximately 75. Because of their relatively high Mg#, magnesian anorthosites should have preceded most FANs in crystallization from the LMO if both are LMO products. Thus, it is important to determine whether the Nd-isotopic data of MAN and FAN are consistent with a co-magmatic origin. We previously reported Sm-Nd data for white clast Dho 908 WC. Mafic minerals in this clast were too small to be physically separated for an isochron. However, we estimated initial Nd-143/Nd-144 for the clast by combining its bulk ("whole rock") Sm-Nd data with an Ar-39-Ar-40 age of 4.42+/-.04 Ga. Here we report additional Sm-Nd data for bulk samples of Dho 908 and its pair Dho 489.

Epidemiology of Pain among Outpatients in Methadone Maintenance Treatment Programs*

PubMed Central

Dhingra, Lara; Masson, Carmen; Perlman, David C.; Seewald, Randy M.; Katz, Judith; McKnight, Courtney; Homel, Peter; Wald, Emily; Jordan, Ashly E.; Young, Christopher; Portenoy, Russell K.

2012-01-01

BACKGROUND This analysis explored the prevalence and correlates of pain in patients enrolled in methadone maintenance treatment (MMT). METHODS Patients in two MMT programs starting a hepatitis care coordination randomized controlled trial completed the Brief Pain Inventory Short-Form and other questionnaires. Associations between clinically significant pain (average daily pain ≥ 5 or mean pain interference ≥ 5 during the past week) and sociodemographic data, medical status, depressive symptoms, and health-related quality of life, and current substance use were evaluated in multivariate analyses. RESULTS The 489 patients included 31.8% women; 30.3% Hispanics, 29.4% non-Hispanic blacks, and 36.0% non-Hispanic whites; 60.1% had hepatitis C, 10.6% had HIV, and 46.8% had moderate or severe depressive symptomatology. Mean methadone dose was 95.7 mg (SD 48.9) and urine drug screening (UDS) was positive for opiates, cocaine, and amphetamines in 32.9%, 40.1%, and 2.9%, respectively. Overall, 237 (48.5%) reported clinically significant pain. Pain treatments included prescribed opioids (38.8%) and non-opioids (48.9%), and self-management approaches (60.8%), including prayer (33.8%), vitamins (29.5%), and distraction (12.7%). Pain was associated with higher methadone dose, more medical comorbidities, prescribed opioid therapy, and more severe depressive symptomatology; it was not associated with UDS or self-reported substance use. CONCLUSIONS Clinically significant pain was reported by almost half of the patients in MMT programs and was associated with medical and psychological comorbidity. Pain was often treated with opioids and was not associated with measures of drug use. Studies are needed to further clarify these associations and determine their importance for pain treatment strategies. PMID:22951068

A review of the automated detection and classification of acute leukaemia: Coherent taxonomy, datasets, validation and performance measurements, motivation, open challenges and recommendations.

PubMed

Alsalem, M A; Zaidan, A A; Zaidan, B B; Hashim, M; Madhloom, H T; Azeez, N D; Alsyisuf, S

2018-05-01

Acute leukaemia diagnosis is a field requiring automated solutions, tools and methods and the ability to facilitate early detection and even prediction. Many studies have focused on the automatic detection and classification of acute leukaemia and their subtypes to promote enable highly accurate diagnosis. This study aimed to review and analyse literature related to the detection and classification of acute leukaemia. The factors that were considered to improve understanding on the field's various contextual aspects in published studies and characteristics were motivation, open challenges that confronted researchers and recommendations presented to researchers to enhance this vital research area. We systematically searched all articles about the classification and detection of acute leukaemia, as well as their evaluation and benchmarking, in three main databases: ScienceDirect, Web of Science and IEEE Xplore from 2007 to 2017. These indices were considered to be sufficiently extensive to encompass our field of literature. Based on our inclusion and exclusion criteria, 89 articles were selected. Most studies (58/89) focused on the methods or algorithms of acute leukaemia classification, a number of papers (22/89) covered the developed systems for the detection or diagnosis of acute leukaemia and few papers (5/89) presented evaluation and comparative studies. The smallest portion (4/89) of articles comprised reviews and surveys. Acute leukaemia diagnosis, which is a field requiring automated solutions, tools and methods, entails the ability to facilitate early detection or even prediction. Many studies have been performed on the automatic detection and classification of acute leukaemia and their subtypes to promote accurate diagnosis. Research areas on medical-image classification vary, but they are all equally vital. We expect this systematic review to help emphasise current research opportunities and thus extend and create additional research fields. Copyright © 2018 Elsevier B.V. All rights reserved.

Suicide in the media: a quantitative review of studies based on non-fictional stories.

PubMed

Stack, Steven

2005-04-01

Research on the effect of suicide stories in the media on suicide in the real world has been marked by much debate and inconsistent findings. Recent narrative reviews have suggested that research based on nonfictional models is more apt to uncover imitative effects than research based on fictional models. There is, however, substantial variation in media effects within the research restricted to nonfictional accounts of suicide. The present analysis provides some explanations of the variation in findings in the work on nonfictional media. Logistic regression techniques applied to 419 findings from 55 studies determined that: (1) studies measuring the presence of either an entertainment or political celebrity were 5.27 times more likely to find a copycat effect, (2) studies focusing on stories that stressed negative definitions of suicide were 99% less likely to report a copycat effect, (3) research based on television stories (which receive less coverage than print stories) were 79% less likely to find a copycat effect, and (4) studies focusing on female suicide were 4.89 times more likely to report a copycat effect than other studies. The full logistic regression model correctly classified 77.3% of the findings from the 55 studies. Methodological differences among studies are associated with discrepancies in their results.

Climate-simulated raceway pond culturing: quantifying the maximum achievable annual biomass productivity of Chlorella sorokiniana in the contiguous USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huesemann, M.; Chavis, A.; Edmundson, S.

Chlorella sorokiniana (DOE 1412) emerged as one of the most promising microalgae strains from the NAABB consortium project, with a remarkable doubling time under optimal conditions of 2.57 hr-1. However, its maximum achievable annual biomass productivity in outdoor ponds in the contiguous United States remained unknown. In order to address this knowledge gap, this alga was cultured in indoor LED-lighted and temperature-controlled raceways in nutrient replete freshwater (BG-11) medium at pH 7 under conditions simulating the daily sunlight intensity and water temperature fluctuations during three seasons in Southern Florida, an optimal outdoor pond culture location for this organism identified bymore » biomass growth modeling. Prior strain characterization indicated that the average maximum specific growth rate (µmax) at 36 ºC declined continuously with pH, with µmax corresponding to 5.92, 5.83, 4.89, and 4.21 day-1 at pH 6, 7, 8, and 9, respectively. In addition, the maximum specific growth rate declined nearly linearly with increasing salinity until no growth was observed above 35 g/L NaCl. In the climate-simulated culturing studies, the volumetric ash-free dry weight-based biomass productivities during the linear growth phase were 57, 69, and 97 mg/L-day for 30-year average light and temperature simulations for January (winter), March (spring), and July (summer), respectively, which corresponds to average areal productivities of 11.6, 14.1, and 19.9 g/m2-day at a constant pond depth of 20.5 cm. The photosynthetic efficiencies (PAR) in the three climate-simulated pond culturing experiments ranged from 4.1 to 5.1%. The annual biomass productivity was estimated as ca. 15 g/m2-day, nearly double the U.S. Department of Energy (DOE) 2015 State of Technology annual cultivation productivity of 8.5 g/m2-day, but this is still significantly below the projected 2022 target of ca. 25 g/m2-day (U.S. DOE, 2016) for economic microalgal biofuel production, indicating the need for additional research in strain biology and system engineering.« less

High Sedimentation Rate Paleomagnetic Records for the Last 70 kyrs From the Chilean Margin (ODP Sites 1233, 1234, 1235)

NASA Astrophysics Data System (ADS)

Stoner, J. S.; Lund, S.; Channell, J. E.; Mix, A. C.; Davies, M. H.; Lamy, F.

2008-12-01

Sediments that accumulate at around 1-m/kyr or greater preserve a paleomagnetic record that, under favorable conditions, may record the original geomagnetic input with little smoothing. However, such great rates of accumulation come with a price as features of interest are often deeply buried and may only be adequately recovered using drilling technologies. Here we present a full-vector geomagnetic reconstruction for the last 70,000 yrs from ultrahigh resolution records obtained through ODP drilling (Leg 202) on the Chilean Margin. ODP Site 1233 (41.0 S, 74.26 W, water depth 838 m) provides a 135-mcd u-channel derived directional paleomagnetic secular variation (PSV) and relative paleointensity (RPI) records. The chronology is constrained by AMS radiocarbon dates and tuning of alkenone sea surface temperature to Antarctic ice core temperature records back to 70,000 years BP. To the north, ODP Sites 1234 (36.13 S, 73.40W, water depth 1015 m) and 1235 (36.9 S, 73.33 W, water depth 489 m) provide independently dated shipboard and developing u-channel paleomagnetic records that reproduce many of the geomagnetic features observed at Site 1233 including excursions and high amplitude PSV intervals, while providing additional radiocarbon and isotopic constraints for development of a regional master chronology. All three Sites have exceptionally high glacial sedimentation rates that average 2-m/kyr for 1233, 80-cm/kyr for 1234 and 1-m/kyr for 1235. Fortuitously, the Laschamp magnetic excursion at Site 1233 occurs during an interval where sedimentation rates exceed 3-m/kyr. The Site 1233 chronology indicates that the Laschamp event, centered at 41,000 yrs BP, has a duration in reverse polarity of only 600 yrs, with polarity transitions occurring in less than 200 yrs within a 1500 yr long interval of low RPI. The path of virtual geomagnetic pole (VGP) positions for the Laschamp excursion at Site 1233 is generally consistent with the hypothesis of a simple field geometry because the large clockwise VGP loop mimics the path seen for other sites recording the same excursion. Unlike prior observations, this path begins and ends at approximately the same Alaskan location after making a complete loop through the Pacific to high (> 80 degrees) southerly latitudes. Insights into the dynamics PSV and RPI, the resolution of magnetic stratigraphies, the geomagnetic controls on cosmic ray shielding and whether these might affect climate will also be touched upon.

Comparisons of Theoretical Methods for Predicting Airfoil Aerodynamic Characteristics

DTIC Science & Technology

2010-08-01

Airfoil ,” Airfoils , U.S. Army Aviation Research, Development and Engineering Command, RDECOM TR 10-D-107, August 2010. [2] Somers, D.M. and...Maughmer, M.D., “Design and Experimental Results for the S407 Airfoil ,” U.S. Army Aviation Research, Development and Engineering Command, RDECOM TR 10-D...S414 Airfoil ,” U.S. Army Aviation Research, Development and Engineering Command, RDECOM TR 10-D-112, August 2010. [5] Somers, D.M. and Maughmer

How close should a student with unilateral hearing loss stay to a teacher in a noisy classroom?

PubMed

Noh, Heil; Park, Yong-Gyu

2012-06-01

To determine the optimal seating position in a noisy classroom for students with unilateral hearing loss (UHL) without any auditory rehabilitation as compared to normal-hearing adults and student peers. Speech discrimination scores (SDS) for babble noise at distances of 3, 4, 6, 8, and 10 m from a speaker were measured in a simulated classroom measuring 300 m3 (reverberation time = 0.43 s). Students with UHL (n = 25, 10-19 years old), normal-hearing students (n = 25), and normal-hearing adults (n = 25). The SDS for the normal-hearing adults at the 3, 4, 6, 8, and 10 m distances were 90.0±6.4%, 84.7±7.9%, 80.6±10.0%, 75.5±12.6%, and 68.8±13.0%, respectively. Those for the normal-hearing students were 90.1±6.2%, 78.1±9.4%, 66.4±10.7%, 61.8±11.2%, and 60.8±10.9%. Those for the UHL group were 81.7±9.0%, 70.2±12.4%, 62.1±17.2%, 52.4±17.1%, and 48.9±17.9%. The UHL group needed a seating position of 4.35 m to achieve an equivalent mean SDS as those for normal-hearing adults seated at 10 m. Likewise, the UHL group needed to be seated at 6.27 m to have an equivalent SDS as the normal-hearing students seated at 10 m. Students with UHL in noisy classrooms require seating ranging from 4.35 m to no further than 6.27 m away from a teacher to obtain a SDS comparable to normal hearing adults and student peers.

Professional ski waxers' exposure to PFAS and aerosol concentrations in gas phase and different particle size fractions.

PubMed

Nilsson, Helena; Kärrman, Anna; Rotander, Anna; van Bavel, Bert; Lindström, Gunilla; Westberg, Håkan

2013-04-01

Previous reports show that professional ski waxers have elevated blood levels of perfluorinated substances (PFAS) such as perfluorooctanoate (PFOA) and are exposed to very high concentrations of PFAS in air during ski waxing. Aerosol exposure increases the risk of cardiovascular disease, and PFOA is a potential hormonal disruptor and carcinogen, and can affect the fatty acid metabolism. Animal studies have shown that 8:2 FTOH can undergo biotransformation to PFOA. For the first time, this study presents an occupational scenario of professional ski waxers who are exposed to extremely high dust levels as well as per- and polyfluorinated compounds. Personal and fixed measurements of total aerosol, inhalable and respirable fractions were performed during World Cup events 2007-2010. The occupational exposure limit (OEL) is exceeded in 37% of the personal measurements with concentrations up to 15 mg m(-3) in air. There are differences between personal and area total aerosol concentrations with levels from personal measurements twice as high as those from the area measurements. The personal levels for FTOH ranged up to 996 μg m(-3) (mean = 114 μg m(-3)) and for PFOA up to 4.89 μg m(-3) (mean = 0.53 μg m(-3)) in ENV+ sorbent samples as compared to the general exposure levels from air reaching only low ng m(-3) (<30 ng m(-3)) levels. FTOHs were not detected in aerosols but PFOA showed an average level of 12 μg m(-3) (range = 1.2-47 μg m(-3)). The ski waxers' exposure to paraffin fumes and PFAS is not in compliance with the occupational exposure standards and by far exceed the general populations' exposure. Preventive measures must be taken to minimize the exposure in this occupational group.

The protein structure prediction problem could be solved using the current PDB library

PubMed Central

Zhang, Yang; Skolnick, Jeffrey

2005-01-01

For single-domain proteins, we examine the completeness of the structures in the current Protein Data Bank (PDB) library for use in full-length model construction of unknown sequences. To address this issue, we employ a comprehensive benchmark set of 1,489 medium-size proteins that cover the PDB at the level of 35% sequence identity and identify templates by structure alignment. With homologous proteins excluded, we can always find similar folds to native with an average rms deviation (RMSD) from native of 2.5 Å with ≈82% alignment coverage. These template structures often contain a significant number of insertions/deletions. The tasser algorithm was applied to build full-length models, where continuous fragments are excised from the top-scoring templates and reassembled under the guide of an optimized force field, which includes consensus restraints taken from the templates and knowledge-based statistical potentials. For almost all targets (except for 2/1,489), the resultant full-length models have an RMSD to native below 6 Å (97% of them below 4 Å). On average, the RMSD of full-length models is 2.25 Å, with aligned regions improved from 2.5 Å to 1.88 Å, comparable with the accuracy of low-resolution experimental structures. Furthermore, starting from state-of-the-art structural alignments, we demonstrate a methodology that can consistently bring template-based alignments closer to native. These results are highly suggestive that the protein-folding problem can in principle be solved based on the current PDB library by developing efficient fold recognition algorithms that can recover such initial alignments. PMID:15653774

Alternative Antimicrobial Commercial Egg Washing Procedures.

PubMed

Hudson, Lauren K; Harrison, Mark A; Berrang, Mark E; Jones, Deana R

2016-07-01

Commercial table eggs are washed prior to packaging. Standard wash procedures use an alkaline pH and warm water. If a cool water method could be developed that would still provide a microbiologically safe egg, the industry may save energy costs associated with water heating. Four wash procedures were evaluated for Salmonella reduction: pH 11 at 48.9°C (industry standard), pH 11 at ambient temperature (∼20°C), pH 6 at 48.9°C, and pH 6 at ambient temperature. Alkaline washes contained potassium hydroxide-based detergent, while pH 6 washes contained approximately 200 ppm of chlorine and a proprietary chlorine stabilizer (T-128). When eggs were inoculated by immersion in a cell suspension of Salmonella Enteritidis and Salmonella Typhimurium, all treatments resulted in a slight and similar reduction of Salmonella numbers (approximately 0.77 log CFU/ml of shell emulsion reduction). When eggs were inoculated by droplet on the shell surface, Salmonella counts were reduced by approximately 5 log CFU when washed with chlorine plus the chlorine stabilizer at both temperatures and with the alkaline wash at the high temperature. The reductions in Salmonella by these treatments were not significantly (P > 0.05) different from each other but were significantly (P < 0.05) more than the reduction observed for the 20°C alkaline treatment and 20°C control water treatments. Ambient temperature acidic washes reduced Salmonella contamination to the same degree as the standard pH 11 warm water wash and may be a viable option to reduce cost, increase shelf life, and slow pathogen growth in and on shell eggs.

Quantitative Characterization Guidelines of Erionite Series Minerals for Regulatory Agencies

NASA Astrophysics Data System (ADS)

Dogan, A.; Dogan, M.

2013-05-01

Erionite is a major health problem where contaminates an environment, which human population exists. Erionite - mesothelioma relationship was first observed in Turkey in 1980's and now the problem is emerging in other places in the world including Mexico. In the past, there have been in vivo or in vitro biological experiments performed using "not correctly characterized" erionite minerals. In addition, in 1997, the erionite was elevated to series status and new erionite minerals - erionite-Na, -K, -Ca - have been proposed. In 2008, erionite characterization guidelines have been proposed (Dogan and Dogan, 2008) and using these criteria, published data was re-evaluated and re-classified; and new mean chemical formula of erionite-Na, -K, -Ca was proposed. If data do not pass the E% and Mg-tests, then any reference to them in the literature is proposed to be disregarded. In some cases, different results have been reported for erionites from the same location by different authors. In these cases, if data do pass both tests but are characterized as from more than one type of erionite, then the mineral should be classified as "undifferentiated" until further clarification. Therefore, we propose (i) Erionite should be correctly characterized using proposed "positive" identification guidelines. (ii) Erionite species (whether it is -Na or -K or -Ca) should be correctly identified. (iii) There should be a close collaboration between medical community researchers and mineralogists in this field so that animal and cell experiments should be performed only with minerals that have passed "positive" identification tests. (iv) An international data bank should be established at one of the mineralogical societies and new data must be evaluated rigorously before being accepted. (v) Regulatory Agencies should ensure that the proposed guidelines for "positive" identification of erionite series minerals, both for a single fiber and a bulk mineral, are followed closely. (vi) Finally, the erionite series minerals - the most carcinogenic minerals known - require a special attention from the mineralogical community, which is a prerequisite to establish their true carcinogenic properties. References: Dogan, A.U., Baris, Y.I., Dogan, M., Emri, S., Steel, I., Elmishad, A.G., and Carbone, M., 2006. Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey. Cancer Research, v. 66 (10), p. 5063-5068, this research paper is highlighted in Nature Reviews-Cancer, v. 6, p. 489. Dogan, A.U. and Dogan, M., 2008, Re-evaluation and re-classification of erionite series minerals, Environmental Geochemistry and Health, v. 30, p. 355-366. Dogan, A.U., Dogan, M., and Hoskins, J.A. 2008, Erionite series minerals: Mineralogical and carcinogenic properties, Environmental Geochemistry and Health, v. 30, p. 367-381.

Causal Reasoning with Mental Models

DTIC Science & Technology

2014-08-08

The initial rubric is equivalent to an exclusive disjunction between the two causal assertions. It 488 yields the following two mental models: 489...are 575 important, whereas the functions of artifacts are important (Ahn, 1998). A genetic code is 576 accordingly more critical to being a goat than

42 CFR 489.102 - Requirements for providers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... such individuals concerning— (i) An individual's rights under State law (whether statutory or... accept or refuse medical or surgical treatment and the right to formulate, at the individual's option... conscience objection. (2) Document in a prominent part of the individual's current medical record, or patient...

42 CFR 489.102 - Requirements for providers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... such individuals concerning— (i) An individual's rights under State law (whether statutory or... accept or refuse medical or surgical treatment and the right to formulate, at the individual's option... conscience objection. (2) Document in a prominent part of the individual's current medical record, or patient...

42 CFR 489.102 - Requirements for providers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... such individuals concerning— (i) An individual's rights under State law (whether statutory or... accept or refuse medical or surgical treatment and the right to formulate, at the individual's option... conscience objection. (2) Document in a prominent part of the individual's current medical record, or patient...

Implications for the origins of pure anorthosites found in the feldspathic lunar meteorites, Dhofar 489 group

NASA Astrophysics Data System (ADS)

Nagaoka, Hiroshi; Takeda, Hiroshi; Karouji, Yuzuru; Ohtake, Makiko; Yamaguchi, Akira; Yoneda, Shigekazu; Hasebe, Nobuyuki

2014-12-01

Remote observation by the reflectance spectrometers onboard the Japanese lunar explorer Kaguya (SELENE) showed the purest anorthosite (PAN) spots (>98% plagioclase) at some large craters. Mineralogical and petrologic investigations on the feldspathic lunar meteorites, Dhofar 489 and Dhofar 911, revealed the presence of several pure anorthosite clasts. A comparison with Apollo nearside samples of ferroan anorthosite (FAN) indicated that of the FAN samples returned by the Apollo missions, sample 60015 is the largest anorthosite with the highest plagioclase abundance and homogeneous mafic mineral compositions. These pure anorthosites (>98% plagioclase) have large chemical variations in Mg number (Mg# = molar 100 × Mg/(Mg + Fe)) of each coexisting mafic mineral. The variations imply that these pure anorthosites underwent complex formation processes and were not formed by simple flotation of plagioclase. The lunar highland samples with pure anorthosite and the PAN observed by Kaguya suggest that pure anorthosite is widely distributed as lunar crust lithology over the entire Moon.

Lactobacillus ghanensis sp. nov., a motile lactic acid bacterium isolated from Ghanaian cocoa fermentations.

PubMed

Nielsen, Dennis S; Schillinger, Ulrich; Franz, Charles M A P; Bresciani, José; Amoa-Awua, Wisdom; Holzapfel, Wilhelm H; Jakobsen, Mogens

2007-07-01

Three Gram-positive, catalase-negative, motile, rod-shaped strains, designated L486, L489(T) and L499, were isolated from fermenting cocoa. These organisms produced DL-lactic acid from glucose without gas formation. Ammonia was not produced from arginine. Acid was produced from amygdalin, D-cellobiose, aesculin, D-fructose, D-glucose, D-galactose, D-mannitol, D-mannose, N-acetylglucosamine, L-rhamnose, sucrose, salicin and D-trehalose. The cell walls contained peptidoglycan of the d-meso-diaminopimelic acid type. A 16S rRNA gene sequence analysis revealed that the isolates belong phylogenetically to the genus Lactobacillus and are closely related to Lactobacillus nagelii, Lactobacillus vini and Lactobacillus satsumensis. Low DNA-DNA reassociation values were obtained between the isolates and the phylogenetically closest neighbours. On the basis of the genetic and phenotypic results, the isolates are considered to represent a novel species, for which the name Lactobacillus ghanensis is proposed. The type strain is L489(T) (=DSM 18630(T)=CCUG 53453(T)).

Model determination in a case of heterogeneity of variance using sampling techniques.

PubMed

Varona, L; Moreno, C; Garcia-Cortes, L A; Altarriba, J

1997-01-12

A sampling determination procedure has been described in a case of heterogeneity of variance. The procedure makes use of the predictive distributions of each data given the rest of the data and the structure of the assumed model. The computation of these predictive distributions is carried out using a Gibbs Sampling procedure. The final criterion to compare between models is the Mean Square Error between the expectation of predictive distributions and real data. The procedure has been applied to a data set of weight at 210 days in the Spanish Pirenaica beef cattle breed. Three proposed models have been compared: (a) Single Trait Animal Model; (b) Heterogeneous Variance Animal Model; and (c) Multiple Trait Animal Model. After applying the procedure, the most adjusted model was the Heterogeneous Variance Animal Model. This result is probably due to a compromise between the complexity of the model and the amount of available information. The estimated heritabilities under the preferred model have been 0.489 ± 0.076 for males and 0.331 ± 0.082 for females. RESUMEN: Contraste de modelos en un caso de heterogeneidad de varianzas usando métodos de muestreo Se ha descrito un método de contraste de modelos mediante técnicas de muestreo en un caso de heterogeneidad de varianza entre sexos. El procedimiento utiliza las distribucviones predictivas de cada dato, dado el resto de datos y la estructura del modelo. El criterio para coparar modelos es el error cuadrático medio entre la esperanza de las distribuciones predictivas y los datos reales. El procedimiento se ha aplicado en datos de peso a los 210 días en la raza bovina Pirenaica. Se han propuesto tres posibles modelos: (a) Modelo Animal Unicaracter; (b) Modelo Animal con Varianzas Heterogéneas; (c) Modelo Animal Multicaracter. El modelo mejor ajustado fue el Modelo Animal con Varianzas Heterogéneas. Este resultado es probablemente debido a un compromiso entre la complejidad del modelo y la cantidad de datos disponibles. Las heredabilidades estimadas bajo el modelo preferido han sido 0,489 ± 0,076 en los machos y 0,331 ± 0,082 en las hembras. 1997 Blackwell Verlag GmbH.

[Parental beliefs on medication and satisfaction with child healthcare].

PubMed

Fernández-Castillo, Antonio; Vílchez-Lara, María José

2015-01-01

The aim of this study is to explore a possible significant relationship between parental beliefs about medication and satisfaction with the medical care their children receive in two different healthcare settings. The study included a total of 1,517 parents whose children were being treated either in pediatric primary care or pediatric emergency centers in eastern Andalusia. Of these, 489 were men and 1,028 women. The research instruments used were the Beliefs about Medicines Questionnaire (BMQ) and the Scale of Satisfaction with Health Care Services. Our results indicate that high levels of negative beliefs about medication were significantly associated with lower levels of parent satisfaction with healthcare received. Satisfaction with pediatric healthcare depends on aspects relating to the healthcare system, but certainly personal psychological and social variables like beliefs and parent’s previous expectations may play an important role too.

Cadmium contamination in cereal-based diets and diet ingredients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Siitonen, P.H.; Thompson, H.C. Jr.

1990-11-01

Cereal-based diet and/or diet ingredient cadmium levels were determined by graphite furnace AAS. Cadmium contamination was 88.3 and 447 ppb in two cereal-based diets, 44.6 and 48.9 ppb in two purified diets, and ranged from less than 1.1 to 22,900 ppb in the ingredients of one cereal-based diet. The major source of cadmium contamination was attributed to the calcium supplement used for diet formulation. Comparative analyses of two purified diet samples and one cereal-based diet by the National Institute of Standards and Technology (NIST, formerly the National Bureau of Standards) and the National Center for Toxicological Research (NCTR) gave virtuallymore » identical results for Cd. A comparative study of Cd levels determined by flame and furnace AAS was also made by the NCTR and the NIST.« less

Lead, cadmium and other metals in serum of pet dogs from an urban area of NW Poland.

PubMed

Tomza-Marciniak, Agnieszka; Pilarczyk, Bogumiła; Bąkowska, Małgorzata; Ligocki, Marek; Gaik, Marcelina

2012-12-01

This study was designed to evaluate the degree of exposure of pet dogs from an urban area of NW Poland to selected metals, including toxic Cd and Pb. The study was conducted on a group of 48 healthy dogs. The serum concentration of the analysed elements followed the order Fe > Al > Zn > Cu > Mn > As > Sr > Pb > Cd > Cr > Ni > V. The presence of cadmium and lead was found in all the serum samples tested. The average contents of these elements were 0.309 and 0.489 μg/mL. The factors that played the greatest role in the intake of the analysed elements were diet and breed-dependent size of dogs. Small-sized dogs had higher concentrations of all elements compared with large dogs, with statistically significant differences noted for Cu, Pb, Cd and Sr. It was also found that dogs receiving commercial and mixed food had more metals in serum compared with dogs on homemade food (except strontium). The present study showed elevated concentrations of some heavy metals (Pb, Cd, Fe and Cu) in serum of pet dogs, which is probably due to the excess elemental load of this area. Given that no information is available on the concentrations of strontium, vanadium and aluminium in dogs, further research is necessary to determine certain reference values which would allow for an easier interpretation of results and evaluation of exposure to these elements.

Astrocytic Acidosis in Hyperglycemic and Complete Ischemia

PubMed Central

Kraig, Richard P.; Chesler, Mitchell

2011-01-01

Summary Nearly complete brain ischemia under normoglycemic conditions results in death of only selectively vulnerable neurons. With prior elevation of brain glucose, such injury is enhanced to include pancel1ular necrosis (i.e., infarction), perhaps because an associated, severe lactic acidosis preferentially injures astrocytes. However, no direct physiologic measurements exist to support this hypothesis. Therefore, we used microelectrodes to measure intracellular pH and passive electrical properties of cortical astrocytes as a first approach to characterizing the physiologic behavior of these cel1s during hyperglycemic and complete ischemia, conditions that produce infarction in reperfused brain. Anesthesized rats (n = 26) were made extremely hyperglycemic (blood glucose, 51.4 ± 2.8 mM) so as to create potentially the most extreme acidic conditions possible; then ischemia was induced by cardiac arrest. Two loci more acidic than the interstitial space (6.17–6.20 pH) were found. The more acidic locus [4.30 ± 0.19 (n = 5); range: 3.82–4.89] was occasional1y seen at the onset of anoxic depolarization, 3–7 min after cardiac arrest. The less acidic locus [5.30 ± 0.07 (n = 53); range 4.46–5.93)] was seen 5–46 min after cardiac arrest. A smal1 negative change in DC potential [8 ± 1 mV (n = 5); range −3 to −12 mV and 7 ± 2 mV (n = 53); range +3 to −31 mV, respectively] was always seen upon impalement of acidic loci, suggesting cellular penetration. In a separate group of five animals, electrical characteristics of these cells were specifically measured (n = 17): membrane potential was −12 ± 0.2 mV (range −3 to −24 mY), input resistance was 114 ± 16 MΩ (range 25–250 MΩ), and time constant was 4.4 ± 0.4 ms (range 3.0–7.9 ms). Injection of horseradish peroxidase into cells from either animal group uniformly stained degenerating astrocytes. These findings establish previously unrecognized properties of ischemic astrocytes that may be prerequisites for infarction from nearly complete ischemia: the capacity to develop profound cellular acidosis and a concomitant reduction in cel1 membrane ion permeability. PMID:2298827

75 FR 4523 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-28

... estimates support the NASS strategic plan to cover all agricultural cash receipts. The authority to collect.... Description of Respondents: Farms; Business or other for-profit. Number of Respondents: 63,305. Frequency of Responses: Reporting: On occasion; Annually; Quarterly; Semi-annually; Monthly. Total Burden Hours: 16,489...

76 FR 79646 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... estimates support the NASS strategic plan to cover all agricultural cash receipts. The authority to collect.... Description of Respondents: Farms; Business or other for-profit. Number of Respondents: 63,305. Frequency of Responses: Reporting: On occasion; Annually; Quarterly; Semi-annually; Monthly. Total Burden Hours: 16,489...

77 FR 2609 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to the Foreign...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-18

..., S.A. DE C.V. (a.k.a. MEDIC EXPRESS, S.A. DE C.V.; a.k.a. GRUPO LOMEDIC), Av. del Parque 489, Col. San Andres, Guadalajara, Jalisco 44810, Mexico; Calle Chicle 234, Colonia El Colli Industrial, Zapopan...

75 FR 60715 - Domestic Sugar Program-FY 2010 and FY 2011 Cane Sugar and Beet Sugar Marketing Allotments and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

...,716 Hawaii Gay & Robinson, Inc 72,401 -18,673 -50,592 3,136 Hawaiian Commercial & Sugar Company... & Sons 495,489 Total Louisiana 1,620,472 Texas: Rio Grande Valley 182,094 Hawaii: Gay & Robinson, Inc 73...

16 CFR 1209.5 - Test procedures for corrosiveness.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., examine the metal coupons over a 40-W appliance light bulb for perforation. (c) Noncorrosiveness... 40-W appliance light bulb. ... maintaining 48.9±1.7 °C (120±3 °F) and 97 ±1.5 percent relative humidity. (2) Crystallizing dishes. Six glass...

16 CFR 1209.5 - Test procedures for corrosiveness.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., examine the metal coupons over a 40-W appliance light bulb for perforation. (c) Noncorrosiveness... 40-W appliance light bulb. ... maintaining 48.9±1.7 °C (120±3 °F) and 97 ±1.5 percent relative humidity. (2) Crystallizing dishes. Six glass...

16 CFR § 1209.5 - Test procedures for corrosiveness.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., examine the metal coupons over a 40-W appliance light bulb for perforation. (c) Noncorrosiveness... 40-W appliance light bulb. ... maintaining 48.9±1.7 °C (120±3 °F) and 97 ±1.5 percent relative humidity. (2) Crystallizing dishes. Six glass...

42 CFR 489.18 - Change of ownership or leasing: Effect on provider agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER..., constitutes change of ownership. (2) Unincorporated sole proprietorship. Transfer of title and property to...) Conditions that apply to assigned agreements. An assigned agreement is subject to all applicable statutes and...

76 FR 53116 - Certain Pasta From Turkey: Extension of Time Limit for the Final Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... DEPARTMENT OF COMMERCE International Trade Administration [A-489-805] Certain Pasta From Turkey... the preliminary results of the administrative review of the antidumping duty order on certain pasta from Turkey (pasta) for the period July [[Page 53117

46 CFR 108.495 - Spare charges.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., offices, lockers, small storerooms, and pantries, open decks, and similar spaces None required. service... extinguishing system is installed. 2. Not required where a fixed foam system is installed in accordance with § 108.489 of this subpart. Table 108.495(b) Classification: Type and size Water liters (gallons) Foam...

46 CFR 108.495 - Spare charges.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., offices, lockers, small storerooms, and pantries, open decks, and similar spaces None required. service... extinguishing system is installed. 2. Not required where a fixed foam system is installed in accordance with § 108.489 of this subpart. Table 108.495(b) Classification: Type and size Water liters (gallons) Foam...

46 CFR 108.495 - Spare charges.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., offices, lockers, small storerooms, and pantries, open decks, and similar spaces None required. service... extinguishing system is installed. 2. Not required where a fixed foam system is installed in accordance with § 108.489 of this subpart. Table 108.495(b) Classification: Type and size Water liters (gallons) Foam...

46 CFR 108.495 - Spare charges.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., offices, lockers, small storerooms, and pantries, open decks, and similar spaces None required. service... extinguishing system is installed. 2. Not required where a fixed foam system is installed in accordance with § 108.489 of this subpart. Table 108.495(b) Classification: Type and size Water liters (gallons) Foam...

46 CFR 108.495 - Spare charges.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., offices, lockers, small storerooms, and pantries, open decks, and similar spaces None required. service... extinguishing system is installed. 2. Not required where a fixed foam system is installed in accordance with § 108.489 of this subpart. Table 108.495(b) Classification: Type and size Water liters (gallons) Foam...

34 CFR 489.21 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2014 CFR

2014-07-01

... strong relationship between skills taught and the literacy and skill requirements of the changing... methods of evaluation— (1) Are clearly explained and appropriate to the project; (2) Will determine how... articles, newsletters, and brochures; (3) Provisions for demonstrating the methods and techniques used by...

34 CFR 489.21 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2013 CFR

2013-07-01

... strong relationship between skills taught and the literacy and skill requirements of the changing... methods of evaluation— (1) Are clearly explained and appropriate to the project; (2) Will determine how... articles, newsletters, and brochures; (3) Provisions for demonstrating the methods and techniques used by...

34 CFR 489.21 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2012 CFR

2012-07-01

... strong relationship between skills taught and the literacy and skill requirements of the changing... methods of evaluation— (1) Are clearly explained and appropriate to the project; (2) Will determine how... articles, newsletters, and brochures; (3) Provisions for demonstrating the methods and techniques used by...

34 CFR 489.21 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2011 CFR

2011-07-01

... strong relationship between skills taught and the literacy and skill requirements of the changing... methods of evaluation— (1) Are clearly explained and appropriate to the project; (2) Will determine how... articles, newsletters, and brochures; (3) Provisions for demonstrating the methods and techniques used by...

34 CFR 489.21 - What selection criteria does the Secretary use?

Code of Federal Regulations, 2010 CFR

2010-07-01

... strong relationship between skills taught and the literacy and skill requirements of the changing... methods of evaluation— (1) Are clearly explained and appropriate to the project; (2) Will determine how... articles, newsletters, and brochures; (3) Provisions for demonstrating the methods and techniques used by...

24 CFR 570.489 - Program administrative requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... determined by HUD to meet the eligibility requirements for designation as an Urban Empowerment Zone pursuant... also include standards of conduct governing employees engaged in the award or administration of...)(2) of this section apply to any person who is an employee, agent, consultant, officer, or elected...

24 CFR 570.489 - Program administrative requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... determined by HUD to meet the eligibility requirements for designation as an Urban Empowerment Zone pursuant... also include standards of conduct governing employees engaged in the award or administration of...)(2) of this section apply to any person who is an employee, agent, consultant, officer, or elected...

42 CFR 489.20 - Basic commitments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... furnished after December 31, 1990. (3) Nurse practitioner and clinical nurse specialist services, as defined in section 1861(s)(2)(K)(ii) of the Act. (4) Certified nurse-midwife services, as defined in section...) Services performed by a nurse practitioner or clinical nurse specialist who meets the applicable definition...

Southern pulpwood production, 1977

Treesearch

Thomas R. Bellamy

1978-01-01

Southern pulpwood production increased 3 percent in 1977 to 48.9 million cords. Roundwood production increased slightly while use of plant byproducts rose 9 percent. The use of plant byproducts continues to increase and now contributes 34 percent of the total. Pulping capacity increased to 100,894 tons per day.

75 FR 1751 - Light-Walled Rectangular Pipe and Tube from Turkey: Extension of Time Limits for Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... DEPARTMENT OF COMMERCE International Trade Administration [A-489-815] Light-Walled Rectangular Pipe and Tube from Turkey: Extension of Time Limits for Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import Administration, International Trade Administration, Department of Commerce...

76 FR 4289 - Light-Walled Rectangular Pipe and Tube From Turkey: Extension of Time Limit for Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... DEPARTMENT OF COMMERCE International Trade Administration [A-489-815] Light-Walled Rectangular Pipe and Tube From Turkey: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import Administration, International Trade Administration, Department of Commerce...

Fossil Chironomidae (Insecta: Diptera) as Paleothermometers in the African Tropics

NASA Astrophysics Data System (ADS)

Eggermont, H.; Heiri, O.; Russell, J.; Vuille, M.; Audenaert, L.; Klaassen, G.; Verschuren, D.

2008-12-01

Reconstruction of Africa's temperature history from natural climate archives such as lake sediments is essential to amend the current scarcity of information on natural tropical climate and ecosystem variability. Chironomids are well-established paleothermometers in north-temperate/boreal regions, but their potential in tropical lakes has never before been assessed. We surveyed sub-fossil chironomid assemblages in surface sediments from 65 lakes and permanent pools in southwestern Uganda and central/southern Kenya, spanning elevations between 489 and 4575 m asl. Using various subsets of lakes and corresponding Surface-Water Temperatures (SWTemp) and Mean Annual Air Temperatures (MATemp), we developed a series of inference models for quantitative paleotemperature reconstruction. Models using both low-, mid- and high-elevation sites suffer to some extent from the small number of samples between 2500 and 3500 m asl, and from the presence of ecologically distinct but morphologically indistinguishable taxa. Models confined to mountain sites produce poorer error statistics, but are less prone to the biogeographical and taxonomic complexities associated with long climatic gradients. Overall, error statistics compare favourably with those of inference models developed for temperate regions, indicating that fossil assemblages of African Chironomidae can be valuable indicators of past temperature change. We subsequently used these models to evaluate whether high-elevation lakes in the Rwenzori Mountains (>3000 m asl) have been impacted by climate warming in recent centuries by comparing temperatures inferred from chironomid assemblages in modern sediments with those derived from chironomid assemblages in sediments deposited within or briefly after the Little Ice Age (1270-1850 AD). Depending on the model used, between 44 and 63% of the 16 lakes studied indicate significantly warmer temperatures in recent times (corresponding with an average MATemp rise of 0.88 ° C, and average SWTemp rise of 1.33 ° C), while all but one of the other lakes show temperature changes that are statistically insignificant. We conclude that chironomid communities in Rwenzori lakes adequately record past temperature changes, with potential for evaluating the impacts of past air temperature variation on the long-term dynamics of the Rwenzori glaciers.

Development and Psychometric Validation of the EDE-QS, a 12 Item Short Form of the Eating Disorder Examination Questionnaire (EDE-Q)

PubMed Central

Gideon, Nicole; Hawkes, Nick; Mond, Jonathan; Saunders, Rob; Tchanturia, Kate; Serpell, Lucy

2016-01-01

Objective The aim of this study was to develop and validate a short form of the Eating Disorder Examination Questionnaire (EDE-Q) for routine, including session by session, outcome assessment. Method The current, 28-item version (6.0) of the EDE-Q was completed by 489 individuals aged 18–72 with various eating disorders recruited from three UK specialist eating disorder services. Rasch analysis was carried out on factors identified by means of principal component analysis, which in combination with expert ratings informed the development of an EDE-Q short form. The shortened questionnaire’s reliability, validity and sensitivity was assessed based on online data collected from students of a UK university and volunteers with a history of eating disorders recruited from a national eating disorders charity aged 18–74 (N = 559). Results A 12-item short form, the Eating Disorder Examination Questionnaire Short (EDE-QS) was derived. The new measure showed high internal consistency (Cronbach’s α = .913) and temporal stability (ICC = .93; p < .001). It was highly correlated with the original EDE-Q (r = .91 for people without ED; r = .82 for people with ED) and other measures of eating disorder and comorbid psychopathology. It was sufficiently sensitive to distinguish between people with and without eating disorders. Discussion The EDE-QS is a brief, reliable and valid measure of eating disorder symptom severity that performs similarly to the EDE-Q and that lends itself for the use of sessional outcome monitoring in treatment and research. PMID:27138364

Relation Between Near Work and Myopia Progression in Student Population

PubMed Central

Muhamedagic, Lejla; Muhamedagic, Belma; Halilovic, Emina Alimanovic; Halimic, Jasmina Alajbegovic; Stankovic, Aleksa; Muracevic, Bedrana

2014-01-01

Aim To determine relation between near work and myopia progression in student population. Causes of myopia occurrence are not sufficiently explained. Methods This retrospective-prospective, descriptive research included 100 students with verified myopia up to -3 Dsph. Ophthalmological examination and measurement diopter-hours variable (Dh) were done twice, in the period from January 2011 until January 2012. Results A multivariate regression analysis of impact on the difference of distance visual acuity without correction to the right and left eye and difference of automatic computer refractometry in cycloplegia of both eyes indicates that, diopter-hours variable (Dh) had statistically significant impact on increase of distance visual acuity difference (right eye OR: I measurement–Dh 1.489, II measurement–Dh 1.544, p<0.05; left eye OR: I measurement–Dh 1.602, II measurement–Dh 1.538, p<0.05) and automatic computer refractometry in cycloplegia (right eye OR: I measurement 1.361, II measurement 1.493, p<0.05; left eye OR: I measurement 0.931, II measurement 1.019, p<0.05) during both measurements. Conclusion Near work cause the increase of myopia. This research opened a perspective for other researches on the impact of near work on myopia. PMID:24944532

Proposed U.S. Space Weather Budget for Fiscal Year 2011 Would Fund Key Programs

NASA Astrophysics Data System (ADS)

Showstack, Randy

2010-09-01

The proposed U.S. federal budget for space weather research for fiscal year (FY) 2011 would provide funding for key space weather programs within several U.S. agencies, including NASA, NOAA, the National Science Foundation (NSF), and the Air Force. Funding for the programs comes ahead of the upcoming solar maximum, a period of the solar cycle with heightened solar activity, projected for 2013. Several officials indicated that while funding is not tied to a particular solar maximum or minimum, available assets could help with studying and preparing for the solar maximum. The proposed FY 2011 budget for the Heliophysics Division within NASA's Science Mission Directorate is $641.9 million, compared with the FY 2010 enacted budget of $627.4 million. Within the proposed budget is $166.9 million for heliophysics research, down slightly from $173 million for FY 2010. The proposed budget would include $31.7 million for heliophysics research and analysis (compared with $31 million for FY 2010); $66.7 million for “other missions and data analysis,” including Cluster II, the Advanced Composition Explorer (ACE), and the Time History of Events and Macroscale Interactions during Substorms (THEMIS) mission; and $48.9 million for sounding rockets.

VizieR Online Data Catalog: Photometric survey of IC 2391, {eta} Cha, and USco (Oelkers+, 2016)

NASA Astrophysics Data System (ADS)

Oelkers, R. J.; Macri, L. M.; Marshall, J. L.; Depoy, D. L.; Lambas, D. G.; Colazo, C.; Stringer, K.

2016-09-01

Our survey instrument, nicknamed AggieCam, consists of an Apogee Alta F16M camera with a 4096*4096pixel Kodak KAD-16083 CCD that is thermoelectrically cooled down to δT=-45°C relative to ambient. Testing of the CCD showed a dark current of 0.2e-/pix/s at temperatures of -25°C relative to ambient. The optics include a Mamiya photographic 300mm lens with a Hoya UV and IR cut filter to restrict the wavelength range to 0.4-0.7μm. The effective aperture size of the telescope is 53.6mm and the total throughput of the system is near 45%. The pixel scale of the detector is 6.2''/pix, leading to a total field of view (hereafter FOV) of ~50deg2. The telescope was installed at the Estacion Astrofisica de Bosque Alegre (hereafter EABA) as part of an ongoing collaboration with the Universidad Nacional de Cordoba, which owns and operates the site. EABA is a research and outreach observatory located at 31.412°S, 64.489°W at an altitude of 1350m, ~50km from the city of Cordoba, province of Cordoba, Argentina. Nearly all observations were carried out remotely from the Mitchell Institute of Fundamental Physics and Astronomy at Texas A&M University in College Station, Texas. Logistical support for the instrument was provided by staff members of the Instituto de Astronomia Teorica y Experimental, Observatorio de Cordoba, and EABA. We targeted three young stellar associations to maximize the science return from our study: IC 2391 (α=8h40m,δ=-53°), the {eta} Chamaeleontis cluster ({eta}Cha,α=8h45m,δ=-79°), and the Upper Scorpius association (USco,α=16h,δ=-24.5°). Any transiting Hot Jupiter (HJ) or pre-main-sequence eclipsing binary (PMB) candidate passing all of the significance tests described in Sections 4.1 and 4.2 was then subject to a series of follow up photometric observations. The 1.54m telescope at EABA provided 300+hr of BVRI photometry to date, with further observations planned. The 0.8m telescope at the McDonald Observatory provided 14hr of BVRI photometry. The Las Cumbres Global Observatory Telescope Network (LCOGT) provided 30hr of gri photometry from their 1m facilities. The Texas A&M University campus observatory 0.5m telescope provided 30hr of gri photometry. Additionally, the 2.1m telescope at the McDonald Observatory, coupled with the Sandiford Echelle Spectrograph provided 14hr of initial spectroscopic follow up during the Spring of 2015. (3 data files).

Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity

PubMed Central

Massey, Suena H.; Schuette, Stephanie A.; Pournajafi-Nazarloo, Hossein; Wisner, Katherine L.; Carter, C. Sue

2016-01-01

Purpose We examined plasma oxytocin concentration and postpartum depression (PPD) symptom severity in women who were not depressed during pregnancy, and whether this differed by major depressive disorder (MDD) history. Methods We assessed psychiatric history and plasma oxytocin in 66 healthy pregnant women in the third trimester (M = 35 ± 3 weeks) and depressive symptoms at 6 weeks postpartum (M = 5.9 ± 0.8 weeks). Linear regression analysis was used to examine oxytocin and PPD symptom severity, and moderation of oxytocin and PPD by past MDD. Results Women with (n = 13) and without (n = 53) past MDD differed in third trimester depressive symptom severity, but not oxytocin level, demographic factors or birth outcomes. Controlling for third trimester depressive symptoms, oxytocin level was unrelated to PPD symptom severity [B(SE) = −.019(.084); β = −.025; t = −.227; p = .821]. However, oxytocin level interacted with past MDD to predict PPD symptom severity [(B(SE) = 7.489(2.429); β = .328; t = 3.084; p = .003]. Higher oxytocin predicted greater PPD symptom severity in women with past MDD (p = .019), but not in women without (p = .216). Conclusions Replication in a larger sample and methodologic challenges are discussed. PMID:26957508

Binder-free 2D titanium carbide (MXene)/carbon nanotube composites for high-performance lithium-ion capacitors.

PubMed

Yu, Peng; Cao, Gejin; Yi, Sha; Zhang, Xiong; Li, Chen; Sun, Xianzhong; Wang, Kai; Ma, Yanwei

2018-03-29

Two-dimensional (2D) MXenes have a very good application prospect in the field of electrochemical energy storage due to their metallic conductivity, high volumetric capacity, mechanical and thermal stability. Herein, we report the preparation of titanium carbide (Ti3C2Tx)/carbon nanotube (CNT) flexible self-supporting composite films by vacuum filtration. The CNTs can effectively prevent Ti3C2Tx from stacking and improve the electrochemical performance. The as-fabricated Ti3C2Tx/CNT film shows a high reversible capacity of 489 mA h g-1 at a current density of 50 mA g-1 together with good cycling performance. The full-cell lithium-ion capacitor (LIC) is assembled using the Ti3C2Tx/CNT film as the anode and activated carbon as the cathode. The LIC exhibits a high energy density of 67 Wh kg-1 (based on the total weight of the anode and the cathode), and a good capacity retention of 81.3% after 5000 cycles. These results suggest that Ti3C2Tx-CNT films are promising as anode materials for lithium ion capacitors.

Improvement in the mechanical properties, proton conductivity, and methanol resistance of highly branched sulfonated poly(arylene ether)/graphene oxide grafted with flexible alkylsulfonated side chains nanocomposite membranes

NASA Astrophysics Data System (ADS)

Liu, Dong; Peng, Jinhua; Li, Zhuoyao; Liu, Bin; Wang, Lei

2018-02-01

Sulfonated polymer/graphene oxide (GO) nanocomposites exhibit excellent properties as proton exchange membranes. However, few investigations on highly branched sulfonated poly(arylene ether)s (HBSPE)/GO nanocomposites as proton exchange membranes are reported. In order to obtain HBSPE-based nanocomposite membranes with better dispersibility and properties, a novel GO containing flexible alkylsulfonated side chains (SGO) is designed and prepared for the first time in this work. The HBSPE/SGO nanocomposite membranes with excellent dispersibility are successfully prepared. The properties of these membranes, including the mechanical properties, ion-exchange capacity, water uptake, proton conductivity, and methanol resistance, are characterized. The nanocomposite membranes exhibit higher tensile strength (32.67 MPa), higher proton conductivity (0.39 S cm-1 at 80 °C) and lower methanol permeability (4.89 × 10-7 cm2 s-1) than the pristine membrane. The nanocomposite membranes also achieve a higher maximum power density (82.36 mW cm-2) than the pristine membrane (67.85 mW cm-2) in single-cell direct methanol fuel cell (DMFC) tests, demonstrating their considerable potential for applications in DMFCs.

Self-pressurization of a flightweight liquid hydrogen tank: Effects of fill level at low wall heat flux

NASA Technical Reports Server (NTRS)

Vandresar, N. T.; Hasan, M. M.; Lin, C.-S.

1991-01-01

Experimental results are presented for the self pressurization and thermal stratification of a 4.89 cu m liquid hydrogen storage tank subjected to low heat flux (2.0 and 3.5 W/sq m) in normal gravity. The test tank was representative of future spacecraft tankage, having a low mass to volume ratio and high performance multilayer thermal insulation. Tests were performed at fill levels of 29 and 49 pcts. (by volume) and complement previous tests at 83 pct. fill. As the heat flux increases, the pressure rise rate at each fill level exceeds the homogeneous rate by an increasing ratio. Herein, this ratio did not exceed a value of 2. The slowest pressure rise rate was observed for the 49 pct. fill level at both heat fluxes. This result is attributed to the oblate spheroidal tank geometry which introduces the variables of wetted wall area, liquid-vapor interfacial area, and ratio of side wall to bottom heating as a function of fill level or liquid depth. Initial tank thermal conditions were found to affect the initial pressure rise rate. Quasi steady pressure rise rates are independent of starting conditions.

12 CFR 48.9 - Margin requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., in retail forex transactions must collect from each retail forex customer an amount of margin not less than: (1) Two percent of the notional value of the retail forex transaction for major currency pairs and 5 percent of the notional value of the retail forex transaction for all other currency pairs...

12 CFR 48.9 - Margin requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., in retail forex transactions must collect from each retail forex customer an amount of margin not less than: (1) Two percent of the notional value of the retail forex transaction for major currency pairs and 5 percent of the notional value of the retail forex transaction for all other currency pairs...

12 CFR 48.9 - Margin requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., in retail forex transactions must collect from each retail forex customer an amount of margin not less than: (1) Two percent of the notional value of the retail forex transaction for major currency pairs and 5 percent of the notional value of the retail forex transaction for all other currency pairs...

78 FR 38043 - Medicare and Medicaid Programs; Application From the American Osteopathic Association/Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... activities; monitoring procedures for provider entities found not in compliance with the conditions or... concerning provider agreements are at 42 CFR part 489 and those pertaining to activities relating to the... appropriately to complaints against accredited facilities. ++ AOA/HFAP's processes and procedures for monitoring...

24 CFR 570.489 - Program administrative requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... advance in accordance with Treasury Circular 1075 (31 CFR part 205). The State shall use procedures to.... (2) Interest on advances. Interest earned by units of general local government on grant funds before... assurance that there has been public disclosure of the conflict and a description of how the public...

42 CFR 426.489 - Board remands.

Code of Federal Regulations, 2010 CFR

2010-10-01

... decision; and (2) Explains why the case is being remanded and the specific actions ordered by the Board. (b) Action by an ALJ on remand. An ALJ takes any action that is ordered by the Board and may take any additional action that is not inconsistent with the Board's remand order. ...

42 CFR 489.29 - Special requirements concerning beneficiaries served by the Indian Health Service, Tribal health...

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER... 42 Public Health 5 2010-10-01 2010-10-01 false Special requirements concerning beneficiaries served by the Indian Health Service, Tribal health programs, and urban Indian organization health...

42 CFR 489.29 - Special requirements concerning beneficiaries served by the Indian Health Service, Tribal health...

Code of Federal Regulations, 2011 CFR

2011-10-01

... HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION PROVIDER AGREEMENTS AND SUPPLIER... 42 Public Health 5 2011-10-01 2011-10-01 false Special requirements concerning beneficiaries served by the Indian Health Service, Tribal health programs, and urban Indian organization health...

33 CFR 149.655 - What are the requirements for helicopter fueling facilities?

Code of Federal Regulations, 2014 CFR

2014-07-01

... helicopter fueling facilities? 149.655 Section 149.655 Navigation and Navigable Waters COAST GUARD... EQUIPMENT Design and Equipment Helicopter Fueling Facilities § 149.655 What are the requirements for helicopter fueling facilities? Helicopter fueling facilities must comply with 46 CFR 108.489 or an equivalent...

33 CFR 149.655 - What are the requirements for helicopter fueling facilities?

Code of Federal Regulations, 2013 CFR

2013-07-01

... helicopter fueling facilities? 149.655 Section 149.655 Navigation and Navigable Waters COAST GUARD... EQUIPMENT Design and Equipment Helicopter Fueling Facilities § 149.655 What are the requirements for helicopter fueling facilities? Helicopter fueling facilities must comply with 46 CFR 108.489 or an equivalent...

33 CFR 149.655 - What are the requirements for helicopter fueling facilities?

Code of Federal Regulations, 2010 CFR

2010-07-01

... helicopter fueling facilities? 149.655 Section 149.655 Navigation and Navigable Waters COAST GUARD... EQUIPMENT Design and Equipment Helicopter Fueling Facilities § 149.655 What are the requirements for helicopter fueling facilities? Helicopter fueling facilities must comply with 46 CFR 108.489 or an equivalent...

33 CFR 149.655 - What are the requirements for helicopter fueling facilities?

Code of Federal Regulations, 2012 CFR

2012-07-01

... helicopter fueling facilities? 149.655 Section 149.655 Navigation and Navigable Waters COAST GUARD... EQUIPMENT Design and Equipment Helicopter Fueling Facilities § 149.655 What are the requirements for helicopter fueling facilities? Helicopter fueling facilities must comply with 46 CFR 108.489 or an equivalent...

33 CFR 149.655 - What are the requirements for helicopter fueling facilities?

Code of Federal Regulations, 2011 CFR

2011-07-01

... helicopter fueling facilities? 149.655 Section 149.655 Navigation and Navigable Waters COAST GUARD... EQUIPMENT Design and Equipment Helicopter Fueling Facilities § 149.655 What are the requirements for helicopter fueling facilities? Helicopter fueling facilities must comply with 46 CFR 108.489 or an equivalent...

34 CFR 489.3 - What activities may the Secretary fund?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., including learning disabilities, upon arrival in the system or at the prison, jail, or detention center. (b..., such as interactive video- and computer-based adult literacy learning: and (2) Include— (i) A... disability, achieves a level of functional literacy commensurate with his or her ability; (B) Is granted...

34 CFR 489.3 - What activities may the Secretary fund?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., including learning disabilities, upon arrival in the system or at the prison, jail, or detention center. (b..., such as interactive video- and computer-based adult literacy learning: and (2) Include— (i) A... disability, achieves a level of functional literacy commensurate with his or her ability; (B) Is granted...

34 CFR 489.3 - What activities may the Secretary fund?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., including learning disabilities, upon arrival in the system or at the prison, jail, or detention center. (b..., such as interactive video- and computer-based adult literacy learning: and (2) Include— (i) A... disability, achieves a level of functional literacy commensurate with his or her ability; (B) Is granted...

40 CFR 60.489 - List of chemicals produced by affected facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 7 2014-07-01 2014-07-01 false List of chemicals produced by affected... Equipment Leaks of VOC in the Synthetic Organic Chemicals Manufacturing Industry for which Construction... of chemicals produced by affected facilities. The following chemicals are produced, as intermediates...

Highlights of the NARMS 2009 Executive Report

USDA-ARS?s Scientific Manuscript database

Salmonella Isolates by Source During 2009, NARMS tested 2,192 isolates of non-typhoidal Salmonella from humans, 489 from retail meats, and 992 from food animals. • The most common serotypes in humans, in order of frequency were Enteritidis (18.7%), Typhimurium (16.9%), Newport (10.8%), Javiana (4.8...

Family System Characteristics and Parental Behaviors as Predictors of Adolescent Substance Use.

ERIC Educational Resources Information Center

Anderson, Allan R.; Henry, Carolyn S.

1994-01-01

Examined adolescent perceptions of family system characteristics and parental behaviors as predictors of adolescent substance use. Findings from 489 high school students indicated that frequency of parental substance use was positively related to adolescent substance use, whereas family bonding and parental support were negatively related to…

77 FR 64313 - Certain Pasta From Turkey: Rescission of Countervailing Duty Administrative Review; 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-19

... DEPARTMENT OF COMMERCE International Trade Administration [C-489-806] Certain Pasta From Turkey...'') is rescinding its administrative review of the countervailing duty order on certain pasta (``pasta... request an administrative review of the countervailing duty order on pasta from Turkey for the period of...

Freshmen Dropouts

ERIC Educational Resources Information Center

Barr, Jim

2007-01-01

This study examines second-term and second-year persistence of 19,489 freshmen at American River College (ARC), a large, urban, public community college near Sacramento, California. Academic and non-academic characteristics are compared between first year dropouts and those students that enroll one year after the first fall term at ARC for two…

77 FR 5213 - Medicare Program; Emergency Medical Treatment and Labor Act (EMTALA): Applicability to Hospital...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services 42 CFR Part 489... & Medicaid Services (CMS), HHS. ACTION: Request for comments. SUMMARY: This request for comments addresses... comments to the following address ONLY: Centers for Medicare & Medicaid Services, Department of Health and...

40 CFR 63.489 - Batch front-end process vents-monitoring equipment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... device (including, but not limited to, a thermocouple, ultra-violet beam sensor, or infrared sensor... temperature monitoring device equipped with a continuous recorder is required. (i) Where an incinerator other than a catalytic incinerator is used, the temperature monitoring device shall be installed in the...

40 CFR 63.489 - Batch front-end process vents-monitoring equipment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... device (including, but not limited to, a thermocouple, ultra-violet beam sensor, or infrared sensor... temperature monitoring device equipped with a continuous recorder is required. (i) Where an incinerator other than a catalytic incinerator is used, the temperature monitoring device shall be installed in the...

40 CFR 63.489 - Batch front-end process vents-monitoring equipment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... device (including, but not limited to, a thermocouple, ultra-violet beam sensor, or infrared sensor... temperature monitoring device equipped with a continuous recorder is required. (i) Where an incinerator other than a catalytic incinerator is used, the temperature monitoring device shall be installed in the...

Forecasting--A Systematic Modeling Methodology. Paper No. 489.

ERIC Educational Resources Information Center

Mabert, Vincent A.; Radcliffe, Robert C.

In an attempt to bridge the gap between academic understanding and practical business use, the Box-Jenkins technique of time series analysis for forecasting future events is presented with a minimum of mathematical notation. The method is presented in three stages: a discussion of traditional forecasting techniques, focusing on traditional…

The Engagement in Schooling of Economically Disadvantaged Parents and Children

ERIC Educational Resources Information Center

Cooper, Carey E.; Crosnoe, Robert

2007-01-01

This study considers academic risk and resilience in the context of economic disadvantage, examining the associations among such disadvantage, parental involvement in education, and children's academic orientation in a sample of 489 inner-city families. Neither parents' nor children's engagement in the educational system was significantly…

42 CFR 489.28 - Special capitalization requirements for HHAs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... free-standing, and proprietary versus non-proprietary status. The determination of the adequacy of the... some cases, an HHA may have all or part of the initial reserve operating funds in cash equivalents. For the purpose of this section, cash equivalents are short-term, highly liquid investments that are...

34 CFR 489.3 - What activities may the Secretary fund?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., including learning disabilities, upon arrival in the system or at the prison, jail, or detention center. (b..., such as interactive video- and computer-based adult literacy learning: and (2) Include— (i) A... disability, achieves a level of functional literacy commensurate with his or her ability; (B) Is granted...

Cost of wetland protection using cable logging systems

Treesearch

Chris B. LeDoux; John E. Baumgras

1990-01-01

Forest managers, loggers, land-use planners, and other decision makers need an understanding of estimating the cost of protecting wetlands using cable logging systems to harvest timber products. Results suggest that protection costs can range from $244.75 to $489.50 per acre depending on the degree of protection desired.

Report: EPA’s Contract Oversight and Controls Over Personal Computers Need Improvement

EPA Pesticide Factsheets

Report #11-P-0705, September 26, 2011. EPA paid the CTS contractor a total of $489,734 over an 11-month period for 3,343 seats—a standard seat includes a leased computer with accessories and technical support—not ordered by the Agency during the period.

42 CFR 489.24 - Special responsibilities of Medicare hospitals in emergency cases.

Code of Federal Regulations, 2013 CFR

2013-10-01

... layperson observer would believe, based on the individual's appearance or behavior, that the individual...'s appearance or behavior, that the individual needs emergency examination or treatment; (3) Is in a... woman or her unborn child) in serious jeopardy; (ii) Serious impairment to bodily functions; or (iii...

42 CFR 489.24 - Special responsibilities of Medicare hospitals in emergency cases.

Code of Federal Regulations, 2011 CFR

2011-10-01

... layperson observer would believe, based on the individual's appearance or behavior, that the individual...'s appearance or behavior, that the individual needs emergency examination or treatment; (3) Is in a... woman or her unborn child) in serious jeopardy; (ii) Serious impairment to bodily functions; or (iii...

42 CFR 489.24 - Special responsibilities of Medicare hospitals in emergency cases.

Code of Federal Regulations, 2012 CFR

2012-10-01

... layperson observer would believe, based on the individual's appearance or behavior, that the individual...'s appearance or behavior, that the individual needs emergency examination or treatment; (3) Is in a... woman or her unborn child) in serious jeopardy; (ii) Serious impairment to bodily functions; or (iii...

42 CFR 489.24 - Special responsibilities of Medicare hospitals in emergency cases.

Code of Federal Regulations, 2010 CFR

2010-10-01

... layperson observer would believe, based on the individual's appearance or behavior, that the individual...'s appearance or behavior, that the individual needs emergency examination or treatment; (3) Is in a... woman or her unborn child) in serious jeopardy; (ii) Serious impairment to bodily functions; or (iii...

42 CFR 489.24 - Special responsibilities of Medicare hospitals in emergency cases.

Code of Federal Regulations, 2014 CFR

2014-10-01

... layperson observer would believe, based on the individual's appearance or behavior, that the individual...'s appearance or behavior, that the individual needs emergency examination or treatment; (3) Is in a... woman or her unborn child) in serious jeopardy; (ii) Serious impairment to bodily functions; or (iii...

Primary Education Teachers' Self-Efficacy Beliefs for Teaching Geography Lessons

ERIC Educational Resources Information Center

Bent, Gert Jan; Bakx, Anouke; den Brok, Perry

2017-01-01

This study was carried out to investigate the primary education teachers' self-efficacy regarding geography education, their beliefs regarding the classroom learning environment, and how these beliefs were related to each other and to teachers' background characteristics. Questionnaire data were collected from 489 Dutch primary school teachers.…

Research and development of therapeutic mAbs: An analysis based on pipeline projects.

PubMed

Geng, Xiaomei; Kong, Xiangjun; Hu, Hao; Chen, Jiayu; Yang, Fengqing; Liang, Hongyu; Chen, Xin; Hu, Yuanjia

2015-01-01

As the subject of active research and development (R&D) in recent decades, monoclonal antibodies have emerged among the major classes of therapeutic agents for treatment of many human diseases, especially cancers, infections, and immunological disorders. This article surveys the landscape of R&D projects of therapeutic monoclonal antibodies (mAbs), which are mostly used for disease immunotherapy, from a number of perspectives, including therapeutic indications, development phases, participants, and citation of related patents. The results of this research can be used as a reference resource for pharmaceutical researchers, investors, and policymakers in the field of therapeutic mAbs.

Research and development of therapeutic mAbs: An analysis based on pipeline projects

PubMed Central

Geng, Xiaomei; Kong, Xiangjun; Hu, Hao; Chen, Jiayu; Yang, Fengqing; Liang, Hongyu; Chen, Xin; Hu, Yuanjia

2015-01-01

As the subject of active research and development (R&D) in recent decades, monoclonal antibodies have emerged among the major classes of therapeutic agents for treatment of many human diseases, especially cancers, infections, and immunological disorders. This article surveys the landscape of R&D projects of therapeutic monoclonal antibodies (mAbs), which are mostly used for disease immunotherapy, from a number of perspectives, including therapeutic indications, development phases, participants, and citation of related patents. The results of this research can be used as a reference resource for pharmaceutical researchers, investors, and policymakers in the field of therapeutic mAbs PMID:26211701

Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elkind, M.M.; Bedford, J.; Benjamin, S.A.

1990-10-01

A study was undertaken by five radiation scientists to examine the feasibility of reducing the uncertainties in the estimation of risk due to protracted low doses of ionizing radiation. In addressing the question of feasibility, a review was made by the study group: of the cellular, molecular, and mammalian radiation data that are available; of the way in which altered oncogene properties could be involved in the loss of growth control that culminates in tumorigenesis; and of the progress that had been made in the genetic characterizations of several human and animal neoplasms. On the basis of this analysis, themore » study group concluded that, at the present time, it is feasible to mount a program of radiation research directed at the mechanism(s) of radiation-induced cancer with special reference to risk of neoplasia due to protracted, low doses of sparsely ionizing radiation. To implement a program of research, a review was made of the methods, techniques, and instruments that would be needed. This review was followed by a survey of the laboratories and institutions where scientific personnel and facilities are known to be available. A research agenda of the principal and broad objectives of the program is also discussed. 489 refs., 21 figs., 14 tabs.« less

The Potential of Mobile Apps for Improving Asthma Self-Management: A Review of Publicly Available and Well-Adopted Asthma Apps.

PubMed

Tinschert, Peter; Jakob, Robert; Barata, Filipe; Kramer, Jan-Niklas; Kowatsch, Tobias

2017-08-02

Effective disease self-management lowers asthma's burden of disease for both individual patients and health care systems. In principle, mobile health (mHealth) apps could enable effective asthma self-management interventions that improve a patient's quality of life while simultaneously reducing the overall treatment costs for health care systems. However, prior reviews in this field have found that mHealth apps for asthma lack clinical evaluation and are often not based on medical guidelines. Yet, beyond the missing evidence for clinical efficacy, little is known about the potential apps might have for improving asthma self-management. The aim of this study was to assess the potential of publicly available and well-adopted mHealth apps for improving asthma self-management. The Apple App store and Google Play store were systematically searched for asthma apps. In total, 523 apps were identified, of which 38 apps matched the selection criteria to be included in the review. Four requirements of app potential were investigated: app functions, potential to change behavior (by means of a behavior change technique taxonomy), potential to promote app use (by means of a gamification components taxonomy), and app quality (by means of the Mobile Application Rating Scale [MARS]). The most commonly implemented functions in the 38 reviewed asthma apps were tracking (30/38, 79%) and information (26/38, 68%) functions, followed by assessment (20/38, 53%) and notification (18/38, 47%) functions. On average, the reviewed apps applied 7.12 of 26 available behavior change techniques (standard deviation [SD]=4.46) and 4.89 of 31 available gamification components (SD=4.21). Average app quality was acceptable (mean=3.17/5, SD=0.58), whereas subjective app quality lied between poor and acceptable (mean=2.65/5, SD=0.87). Additionally, the sum scores of all review frameworks were significantly correlated (lowest correlation: r 36 =.33, P=.04 between number of functions and gamification components; highest correlation: r 36 =.80, P<.001 between number of behavior change techniques and gamification components), which suggests that an app's potential tends to be consistent across review frameworks. Several apps were identified that performed consistently well across all applied review frameworks, thus indicating the potential mHealth apps offer for improving asthma self-management. However, many apps suffer from low quality. Therefore, app reviews should be considered as a decision support tool before deciding which app to integrate into a patient's asthma self-management. Furthermore, several research-practice gaps were identified that app developers should consider addressing in future asthma apps. ©Peter Tinschert, Robert Jakob, Filipe Barata, Jan-Niklas Kramer, Tobias Kowatsch. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 02.08.2017.

The Potential of Mobile Apps for Improving Asthma Self-Management: A Review of Publicly Available and Well-Adopted Asthma Apps

PubMed Central

Tinschert, Peter; Jakob, Robert; Barata, Filipe; Kramer, Jan-Niklas

2017-01-01

Background Effective disease self-management lowers asthma’s burden of disease for both individual patients and health care systems. In principle, mobile health (mHealth) apps could enable effective asthma self-management interventions that improve a patient’s quality of life while simultaneously reducing the overall treatment costs for health care systems. However, prior reviews in this field have found that mHealth apps for asthma lack clinical evaluation and are often not based on medical guidelines. Yet, beyond the missing evidence for clinical efficacy, little is known about the potential apps might have for improving asthma self-management. Objective The aim of this study was to assess the potential of publicly available and well-adopted mHealth apps for improving asthma self-management. Methods The Apple App store and Google Play store were systematically searched for asthma apps. In total, 523 apps were identified, of which 38 apps matched the selection criteria to be included in the review. Four requirements of app potential were investigated: app functions, potential to change behavior (by means of a behavior change technique taxonomy), potential to promote app use (by means of a gamification components taxonomy), and app quality (by means of the Mobile Application Rating Scale [MARS]). Results The most commonly implemented functions in the 38 reviewed asthma apps were tracking (30/38, 79%) and information (26/38, 68%) functions, followed by assessment (20/38, 53%) and notification (18/38, 47%) functions. On average, the reviewed apps applied 7.12 of 26 available behavior change techniques (standard deviation [SD]=4.46) and 4.89 of 31 available gamification components (SD=4.21). Average app quality was acceptable (mean=3.17/5, SD=0.58), whereas subjective app quality lied between poor and acceptable (mean=2.65/5, SD=0.87). Additionally, the sum scores of all review frameworks were significantly correlated (lowest correlation: r36=.33, P=.04 between number of functions and gamification components; highest correlation: r36=.80, P<.001 between number of behavior change techniques and gamification components), which suggests that an app’s potential tends to be consistent across review frameworks. Conclusions Several apps were identified that performed consistently well across all applied review frameworks, thus indicating the potential mHealth apps offer for improving asthma self-management. However, many apps suffer from low quality. Therefore, app reviews should be considered as a decision support tool before deciding which app to integrate into a patient’s asthma self-management. Furthermore, several research-practice gaps were identified that app developers should consider addressing in future asthma apps. PMID:28768606

Internet-Based Injury Profile Developer (IPD) User’s Manual, Version 1.0

DTIC Science & Technology

2002-10-01

NAVAL HEALTH RESEARCH CENTER Internet-based Injury Profile Developer (IPD) User’s Manual Version 1.0 M. Knapp M. Galarneau...NAVAL HEALTH RESEARCH CENTER P. O. BOX 85122 SAN DIEGO, CA 92186-5122...Kizakevich2 1Naval Health Research Center P.O. Box 85122 San Diego, CA 92182-5122 2Research Triangle Institute P.O. Box 12194

Improvement of ε-poly-L-lysine production through seed stage development based on in situ pH monitoring.

PubMed

Sun, Qi-Xing; Chen, Xu-Sheng; Ren, Xi-Dong; Mao, Zhong-Gui

2015-01-01

Nissin, natamycin, and ε-poly-L-lysine (ε-PL) are three safe, microbial-produced food preservatives used today in the food industry. However, current industrial production of ε-PL is only performed in several countries. In order to realize large-scale ε-PL production by fermentation, the effects of seed stage on cell growth and ε-PL production were investigated by monitoring of pH in situ in a 5-L laboratory-scale fermenter. A significant increase in ε-PL production in fed-batch fermentation by Streptomyces sp. M-Z18 was achieved, at 48.9 g/L, through the optimization of several factors associated with seed stage, including spore pretreatment, inoculum age, and inoculum level. Compared with conventional fermentation approaches using 24-h-old shake-flask seed broth as inoculum, the maximum ε-PL concentration and productivity were enhanced by 32.3 and 36.6 %, respectively. The effect of optimized inoculum conditions on ε-PL production on a large scale was evaluated using a 50-L pilot-scale fermenter, attaining a maximum ε-PL production of 36.22 g/L in fed-batch fermentation, constituting the first report of ε-PL production at pilot scale. These results will be helpful for efficient ε-PL production by Streptomyces at pilot and plant scales.

One-Step Reverse-Transcription FRET-PCR for Differential Detection of Five Ebolavirus Species

PubMed Central

Lu, Guangwu; Zhang, Jilei; Zhang, Chuntao; Li, Xiaolu; Shi, Dawei; Yang, Zhaopeng; Wang, Chengming

2015-01-01

Ebola is an emerging infectious disease caused by a deadly virus belonging to the family Filoviridae, genus Ebolavirus. Based on their geographical distribution, Ebolavirus has been classified into total five species so far, mainly Zaire, Sudan, Taï Forest, Bundibugyo and Reston. It is important to be able to differentiate the Ebolavirus species as they significantly differ in pathogenicity and more than one species can be present in an area. We have developed a one-step step-down RT-PCR detecting all five Ebolavirus species with high sensitivity (1 copy of Ebolavirus DNA, 10 copies of RNA and 320 copies of RNA spiked in 1 ml whole blood). The primers and FRET-probes we designed enabled us to differentiate five Ebolavirus species by distinct T m (Zaire: flat peaks between 53.0°C and 56.9°C; Sudan: 51.6°C; Reston: flat peaks between 47.5°C and 54.9°C; Tai Forest: 52.8°C; Bundibugyo: dual peaks at 48.9°C and 53.5°C), and by different amplicon sizes (Zaire 255bp, Sudan 211bp, Reston 192bp, Taï Forest 166bp, Bundibugyo 146bp). This one-size-fit-all assay enables the rapid detection and discrimination of the five Ebolavirus species in a single reaction. PMID:26017916

Concept Analysis and the Advance of Nursing Knowledge: State of the Science.

PubMed

Rodgers, Beth L; Jacelon, Cynthia S; Knafl, Kathleen A

2018-04-24

Despite an overwhelming increase in the number of concept analyses published since the early 1970s, there are significant limitations to the impact of this work in promoting progress in nursing science. We conducted an extensive review of concept analyses published between 1972 and 2017 to identify patterns in analysis and followed this with exploration of an exemplar related to the concept of normalization to demonstrate the capabilities of analysis for promoting concept development and progress. Scoping review of peer-reviewed literature published in the Cumulative Index to Nursing and Allied Health Literature (CINAHL) in which the terms "concept analysis," "concept clarification," and "concept derivation" appeared in any part of the reference. The original search returned 3,489 articles. This initial pool was refined to a final sample of 958 articles published in 223 journals and addressing 604 concepts. A review of citations of the original analysis of the concept of normalization resulted in 75 articles selected for closer examination of the process of concept development. Review showed a clear pattern of repetition of analysis of the same concept, growth in number of published analyses, preponderance of first authors with master's degrees, and 43 distinct descriptions of methods. Review of the 75 citations to the normalization analysis identified multiple ways concept analysis can inform subsequent research and theory development. Conceptual work needs to move beyond the level of "concept analysis" involving clear linkage to the resolution of problems in the discipline. Conceptual work is an important component of progress in the knowledge base of a discipline, and more effective use of concept development activities are needed to maximize the potential of this important work. It is important to the discipline that we facilitate progress in nursing science on a theoretical and conceptual level as a part of cohesive and systematic development of the discipline. The absence of effective concepts impedes the ability to recognize, discuss, define, and conduct studies important to clinical practice and research. This article reflects the pressing need as well as the potential for concept analysis work to be approached in a way that promotes nursing science and enables conceptually sound research to improve clinical care. © 2018 Sigma Theta Tau International.

Synthetic Ni3S2/Ni hybrid architectures as potential contrast agents in MRI

NASA Astrophysics Data System (ADS)

Ma, J.; Chen, K.

2016-04-01

Traditional magnetic resonance imaging (MRI) contrast agents mainly include superparamagnetic (SPM) iron oxide nanoparticle as T 2 contrast agent for liver and paramagnetic Gd (III)-chelate as T 1 contrast agent for all organs. In this work, weak ferromagnetic kale-like and SPM cabbage-like Ni3S2@Ni hybrid architectures were synthesized and evaluated as potential T 1 MRI contrast agents. Their relatively small r 2/r 1 ratios of 2.59 and 2.38, and high r 1 values of 11.27 and 4.89 mmol-1 L s-1 (for the kale-like and cabbage-like Ni3S2@Ni, respectively) will shed some light on the development of new-type MRI contrast agents.

Mobile Technology for Improved Family Planning (MOTIF): the development of a mobile phone-based (mHealth) intervention to support post-abortion family planning (PAFP) in Cambodia.

PubMed

Smith, Chris; Vannak, Uk; Sokhey, Ly; Ngo, Thoai D; Gold, Judy; Free, Caroline

2016-01-05

The objective of this paper is to outline the formative research process used to develop the MOTIF mobile phone-based (mHealth) intervention to support post-abortion family planning in Cambodia. The formative research process involved literature reviews, interviews and focus group discussions with clients, and consultation with clinicians and organisations implementing mHealth activities in Cambodia. This process led to the development of a conceptual framework and the intervention. Key findings from the formative research included identification of the main reasons for non-use of contraception and patterns of mobile phone use in Cambodia. We drew on components of existing interventions and behaviour change theory to develop a conceptual framework. A multi-faceted voice-based intervention was designed to address health concerns and other key determinants of contraception use. Formative research was essential in order to develop an appropriate mHealth intervention to support post-abortion contraception in Cambodia. Each component of the formative research contributed to the final intervention design.

Membrane properties and cell ultrastructure of taste receptor cells in Necturus lingual slices.

PubMed

Bigiani, A; Kim, D J; Roper, S D

1996-05-01

1. Whole cell patch-clamp recordings and electron micrographs were obtained from cells in Necturus taste buds in lingual slices to study their membrane properties and to correlate these properties with cell ultrastructure. 2. Two different populations of taste receptor cells could be identified: one type possessed voltage-gated Na+ and K+ (noninactivating) currents (group 1 cells); the other type possessed only K+ (inactivating) currents (group 2 cells). 3. The zero-current ("resting") potential (Vo) and whole cell resistance (Ro) of these two types of taste cells differed significantly. For group 1 cells, on average, Vo = -75 mV and Ro = 24.6 G omega, and for group 2 cells, Vo = -49 mV and Ro = 48.9 G omega. The difference in Ro was not explained completely by differences in cell sizes, suggesting that intrinsic membrane properties differed between the populations. 4. Cells injected with biocytin were the electron microscope after tissues were reacted with majority (14 of 16) of cells with voltage-gated Na+ and K+ currents (group 1 cells) were characterized by abundant rough endoplasmic reticulum and dense granular packets in the apical process. These are features of dark cells. All the cells that only possessed K+ currents (group 2 cells) were characterize by well-developed smooth endoplasmic reticulum and an absence granular packets. These features characterize light cells. 5. These findings indicate that there is a good, although not exact, correlation between electrophysiological properties and cell morphotype in Necturus taste bud cells. All dark cells possessed Na+ and K+ currents and thus would be expected to be capable of generating action potentials. Most light cells only possessed outward K+ currents and thus would be incapable of generating action potentials.

Population pharmacokinetic model for tumescent lidocaine in women undergoing breast cancer surgery.

PubMed

Riff, Camille; Bourgoin, Aurélie; Marsot, Amelie; Allanioux, Laurent; Leone, Marc; Blin, Olivier; Guilhaumou, Romain

2018-06-16

Tumescent lidocaine anesthesia (TLA) is an opportunity to perform mastectomy for breast cancer without general anesthesia in elderly women. Few reports are available on the pharmacokinetics of lidocaine in a context of TLA during a unilateral mastectomy. The aim of this study was to describe lidocaine pharmacokinetics in elderly women undergoing breast cancer surgery after TLA and to explore the risk of the toxicity of this technique. A prospective study was conducted to examine the pharmacokinetics of lidocaine in women undergoing TLA. TLA consists of an intradermal lidocaine instillation (20 mL, 1% [200 mg]) followed by a tumescent lidocaine infiltration (100 mL of 1% lidocaine [1000 mg] and 0.5 mg epinephrine to 1 L Ringer's lactate) via an infusion pump. A population pharmacokinetic (popPK) analysis was performed using the nonlinear mixed effects model (NONMEM). The analysis included 116 observations from 17 women with a median (range) age of 83.4 (60.5-90.0). The median tumescent lidocaine dose was 800 mg (range 375-1000 mg) infused over 48.0 ± 11.0 min. A one-compartment disposition model with first order absorption, two input compartments, and a central elimination best described the pharmacokinetics of lidocaine. The estimates (between subject variability; relative standard error, %) of apparent volume, apparent clearance, tumescent absorption rate, and instillation absorption rate were 195.0 (46.3; 14.5%) L, 24.7 (48.9; 13.3%) L h -1 , 0.28 (39.6; 13.8%) h -1 , and 2.56 (135.3; 44.9%) h -1 , respectively. This is the first popPK model developed to describe kinetic profiles of TLA. These findings confirm the slow diffusion of lidocaine from the tumescent deposit.

Bridging the gap: facilities and technologies for development of early stage therapeutic mAb candidates.

PubMed

Munro, Trent P; Mahler, Stephen M; Huang, Edwin P; Chin, David Y; Gray, Peter P

2011-01-01

Therapeutic monoclonal antibodies (mAbs) currently dominate the biologics marketplace. Development of a new therapeutic mAb candidate is a complex, multistep process and early stages of development typically begin in an academic research environment. Recently, a number of facilities and initiatives have been launched to aid researchers along this difficult path and facilitate progression of the next mAb blockbuster. Complementing this, there has been a renewed interest from the pharmaceutical industry to reconnect with academia in order to boost dwindling pipelines and encourage innovation. In this review, we examine the steps required to take a therapeutic mAb from discovery through early stage preclinical development and toward becoming a feasible clinical candidate. Discussion of the technologies used for mAb discovery, production in mammalian cells and innovations in single-use bioprocessing is included. We also examine regulatory requirements for product quality and characterization that should be considered at the earliest stages of mAb development. We provide details on the facilities available to help researchers and small-biotech build value into early stage product development, and include examples from within our own facility of how technologies are utilized and an analysis of our client base.

Dispersal Routes and Habitat Utilization of Juvenile Atlantic Bluefin Tuna, Thunnus thynnus, Tracked with Mini PSAT and Archival Tags

PubMed Central

Galuardi, Benjamin; Lutcavage, Molly

2012-01-01

Between 2005 and 2009, we deployed 58 miniature pop-up satellite archival tags (PSAT) and 132 implanted archival tags on juvenile Atlantic bluefin tuna (age 2–5) in the northwest Atlantic Ocean. Data returned from these efforts (n = 26 PSATs, 1 archival tag) revealed their dispersal routes, horizontal and vertical movements and habitat utilization. All of the tagged bluefin tuna remained in the northwest Atlantic for the duration observed, and in summer months exhibited core-use of coastal seas extending from Maryland to Cape Cod, MA, (USA) out to the shelf break. Their winter distributions were more spatially disaggregated, ranging south to the South Atlantic Bight, northern Bahamas and Gulf Stream. Vertical habitat patterns showed that juvenile bluefin tuna mainly occupied shallow depths (mean  = 5–12 m, sd  = 15–23.7 m) and relatively warm water masses in summer (mean  = 17.9–20.9°C, sd  = 4.2–2.6°C) and had deeper and more variable depth patterns in winter (mean  = 41–58 m, sd  = 48.9–62.2 m). Our tagging results reveal annual dispersal patterns, behavior and oceanographic associations of juvenile Atlantic bluefin tuna that were only surmised in earlier studies. Fishery independent profiling from electronic tagging also provide spatially and temporally explicit information for evaluating dispersals rates, population structure and fisheries catch patterns. PMID:22629461

Variation in supermarket exposure to energy-dense snack foods by socio-economic position.

PubMed

Cameron, Adrian J; Thornton, Lukar E; McNaughton, Sarah A; Crawford, David

2013-07-01

The present study aimed to examine the availability of energy-dense,nutrient-poor snack foods (and fruits and vegetables) in supermarkets located insocio-economically advantaged and disadvantaged neighbourhoods. Cross-sectional supermarket audit. Melbourne, Australia. Measures included product shelf space and number of varieties for soft drinks, crisps, chocolate, confectionery and fruits and vegetables, as well as store size. Thirty-five supermarkets (response 83 %) from neighbourhoods in the lowest and highest quintile of socio-economic disadvantage. Shelf space allocated to soft drinks (23?6m v. 17?7m, P50?006), crisps (16?5m v. 13?0m, P50?016), chocolate (12?2m v. 10?1m, P50?022) and confectionery (6?7m v. 5?1m, P50?003) was greater in stores from socioeconomically disadvantaged neighbourhoods. After adjustment for store size (stores in disadvantaged areas being larger), shelf space for confectionery (6?3m v. 5?6m, P50?024) and combined shelf space for all energy-dense foods and drinks (55?0m v. 48?9m, P50?017) remained greater in stores from socio-economically disadvantaged neighbourhoods. The ratio of shelf space allocated to fruits and vegetables to that for energy-dense snack foods also varied by socio-economic disadvantage after adjustment for store size (most disadvantaged v. least disadvantaged: 1?7 v. 2?1, P50?025). Varieties of fruits and vegetables and chocolate bars were more numerous in less disadvantaged areas (P,0?05). Exposure to energy-dense snack foods and soft drinks in supermarketswas greater in socio-economically disadvantaged neighbourhoods. Thismay impact purchasing, consumption and cultural norms related to eatingbehaviours and may therefore work against elimination of the known socioeconomicgradient in obesity levels. Reform of supermarket stocking practicesmay represent an effective means of obesity prevention.

78 FR 76846 - National Library of Medicine; Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... accordance with the provisions set forth in section 552b(c)(6), Title 5 U.S.C., as amended for review... p.m. Agenda: Review of research and development programs and preparation of reports of the Lister....gov . Open: April 11, 2014, 10:00 a.m. to 11:00 a.m. Agenda: Review of research and development...

Neo-deterministic seismic hazard scenarios for India—a preventive tool for disaster mitigation

NASA Astrophysics Data System (ADS)

Parvez, Imtiyaz A.; Magrin, Andrea; Vaccari, Franco; Ashish; Mir, Ramees R.; Peresan, Antonella; Panza, Giuliano Francesco

2017-11-01

Current computational resources and physical knowledge of the seismic wave generation and propagation processes allow for reliable numerical and analytical models of waveform generation and propagation. From the simulation of ground motion, it is easy to extract the desired earthquake hazard parameters. Accordingly, a scenario-based approach to seismic hazard assessment has been developed, namely the neo-deterministic seismic hazard assessment (NDSHA), which allows for a wide range of possible seismic sources to be used in the definition of reliable scenarios by means of realistic waveforms modelling. Such reliable and comprehensive characterization of expected earthquake ground motion is essential to improve building codes, particularly for the protection of critical infrastructures and for land use planning. Parvez et al. (Geophys J Int 155:489-508, 2003) published the first ever neo-deterministic seismic hazard map of India by computing synthetic seismograms with input data set consisting of structural models, seismogenic zones, focal mechanisms and earthquake catalogues. As described in Panza et al. (Adv Geophys 53:93-165, 2012), the NDSHA methodology evolved with respect to the original formulation used by Parvez et al. (Geophys J Int 155:489-508, 2003): the computer codes were improved to better fit the need of producing realistic ground shaking maps and ground shaking scenarios, at different scale levels, exploiting the most significant pertinent progresses in data acquisition and modelling. Accordingly, the present study supplies a revised NDSHA map for India. The seismic hazard, expressed in terms of maximum displacement (Dmax), maximum velocity (Vmax) and design ground acceleration (DGA), has been extracted from the synthetic signals and mapped on a regular grid over the studied territory.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ren-Chun; Zhang, You-Juan; Yuan, Bai-Qing

A new three-dimensional framework iodide, (DabcoH){sub 2}[(Dabco){sub 2}Ag{sub 14}I{sub 16}] (1), was solvothermal synthesized by transformation of dense AgI using p-methylthiophenol as mineralizer, and characterized by elemental analysis, single-crystal and powder X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry analysis, UV–vis diffuse reflectance spectroscopy and fluorescence spectroscopy. Compound 1 crystallizes in the trigonal space group R-3c, a=13.4452(2) Å, c=63.725(2) Å, V=9976.5(4) Å{sup 3}, Z=6. It features a 3D silver-rich [(Dabco){sub 2}Ag{sub 14}I{sub 16}]{sup 2−} anionic framework built up from corner-sharing of hybrid [(Dabco){sub 2}Ag{sub 14}I{sub 19}]{sup 5−} clusters, with protonated DabcoH{sup +} as counterions residing in the channels. UV–vis reflectance spectroscopymore » reveals the band gap of 1 is 3.3 eV. Compound 1 exhibits a strong photoluminescent emission band at 567 nm upon excitation at 489 nm. - Graphical abstract: A new 3-D iodoargentate was synthesized by transformation of dense AgI in I{sup −}-deficient system using thiophenol as mineralizer. - Highlights: • We have developed a new method to synthesize iodide using thiophenol as mineralizer. • A new 3D iodide, (DabcoH){sub 2}[(Dabco){sub 2}Ag{sub 14}I{sub 16}], was synthesized by transformation of dense AgI under solvothermal condition. • The compound features a 3D Ag–I framework with highest Ag/I ratio. • Compound 1 is a semiconductor with the band gap of 3.3 eV. • Compound 1 exhibits a strong photoluminescent emission band at 567 nm upon excitation at 489 nm.« less

High Areal Capacity Si/LiCoO 2 Batteries from Electrospun Composite Fiber Mats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Self, Ethan C.; Naguib, Michael; Ruther, Rose E.

Here, freestanding nanofiber mat Li-ion battery anodes containing Si nanoparticles, carbon black, and poly(acrylic acid) (Si/C/PAA) are prepared using electrospinning. The mats are compacted to a high fiber volume fraction (~0.85), and interfiber contacts are welded by exposing the mat to methanol vapor. A compacted+welded fiber mat anode containing 40 wt % Si exhibits high capacities of 1,484 mA h g -1 (3,500 mA h gmore » $$-1\\atop{Si}$$) at 0.1 C and 489 mAh g -1 at 1 C and good cycling stability (e.g., 73% capacity retention over 50 cycles). Post-mortem analysis of the fiber mats shows that the overall electrode structure is preserved during cycling. Whereas many nanostructured Si anodes are hindered by their low active material loadings and densities, thick, densely packed Si/C/PAA fiber mat anodes reported here have high areal and volumetric capacities (e.g., 4.5 mA h cm -2 and 750 mA h cm -3, respectively). A full cell containing an electrospun Si/C/PAA anode and electrospun LiCoO 2-based cathode has a high specific energy density of 270 Wh kg -1. The excellent performance of the electrospun Si/C/PAA fiber mat anodes is attributed to the: (i) PAA binder which interacts with the SiO x surface of Si nanoparticles and (ii) high material loading, high fiber volume fraction, and welded interfiber contacts of the electrospun mats« less

Occupational exposure to magnetic fields and the risk of brain tumors

PubMed Central

Coble, Joseph B.; Dosemeci, Mustafa; Stewart, Patricia A.; Blair, Aaron; Bowman, Joseph; Fine, Howard A.; Shapiro, William R.; Selker, Robert G.; Loeffler, Jay S.; Black, Peter M.; Linet, Martha S.; Inskip, Peter D.

2009-01-01

We investigated the association between occupational exposure to extremely low-frequency magnetic fields (MFs) and the risk of glioma and meningioma. Occupational exposure to MF was assessed for 489 glioma cases, 197 meningioma cases, and 799 controls enrolled in a hospital-based case–control study. Lifetime occupational history questionnaires were administered to all subjects; for 24% of jobs, these were supplemented with job-specific questionnaires, or “job modules,” to obtain information on the use of electrically powered tools or equipment at work. Job-specific quantitative estimates for exposure to MF in milligauss were assigned using a previously published job exposure matrix (JEM) with modification based on the job modules. Jobs were categorized as ≤1.5 mG, >1.5 to <3.0 mG, and ≥3.0 mG. Four exposure metrics were evaluated: (1) maximum exposed job; (2) total years of exposure >1.5 mG; (3) cumulative lifetime exposure; and (4) average lifetime exposure. Odds ratios (ORs) were calculated using unconditional logistic regression with adjustment for the age, gender, and hospital site. The job modules increased the number of jobs with exposure ≥3.0 mG from 4% to 7% relative to the JEM. No statistically significant elevation in ORs or trends in ORs across exposure categories was observed using four different exposure metrics for the three tumor types analyzed. Occupational exposure to MFs assessed using job modules was not associated with an increase in the risk for glioma, glioblastoma, or meningioma among the subjects evaluated in this study. PMID:19234232

High Areal Capacity Si/LiCoO 2 Batteries from Electrospun Composite Fiber Mats

DOE PAGES

Self, Ethan C.; Naguib, Michael; Ruther, Rose E.; ...

2017-03-24

Here, freestanding nanofiber mat Li-ion battery anodes containing Si nanoparticles, carbon black, and poly(acrylic acid) (Si/C/PAA) are prepared using electrospinning. The mats are compacted to a high fiber volume fraction (~0.85), and interfiber contacts are welded by exposing the mat to methanol vapor. A compacted+welded fiber mat anode containing 40 wt % Si exhibits high capacities of 1,484 mA h g -1 (3,500 mA h gmore » $$-1\\atop{Si}$$) at 0.1 C and 489 mAh g -1 at 1 C and good cycling stability (e.g., 73% capacity retention over 50 cycles). Post-mortem analysis of the fiber mats shows that the overall electrode structure is preserved during cycling. Whereas many nanostructured Si anodes are hindered by their low active material loadings and densities, thick, densely packed Si/C/PAA fiber mat anodes reported here have high areal and volumetric capacities (e.g., 4.5 mA h cm -2 and 750 mA h cm -3, respectively). A full cell containing an electrospun Si/C/PAA anode and electrospun LiCoO 2-based cathode has a high specific energy density of 270 Wh kg -1. The excellent performance of the electrospun Si/C/PAA fiber mat anodes is attributed to the: (i) PAA binder which interacts with the SiO x surface of Si nanoparticles and (ii) high material loading, high fiber volume fraction, and welded interfiber contacts of the electrospun mats« less

Schizothorax prenanti corticotropin-releasing hormone (CRH): molecular cloning, tissue expression, and the function of feeding regulation.

PubMed

Wang, Tao; Zhou, Chaowei; Yuan, Dengyue; Lin, Fangjun; Chen, Hu; Wu, Hongwei; Wei, Rongbin; Xin, Zhiming; Liu, Ju; Gao, Yundi; Li, Zhiqiong

2014-10-01

Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. For a better understanding of the structure and function of the CRH gene and to study its effect on feeding regulation in cyprinid fish, the cDNA of the CRH gene from the brain of Schizothorax prenanti was cloned and sequenced. The full-length CRH cDNA consisted of 1,046 bp with an open reading frame of 489 bp encoding a protein of 162 amino acids. Real-time quantitative PCR analyses revealed that CRH was widely expressed in central and peripheral tissues. In particular, high expression level of CRH was detected in brain. Furthermore, CRH mRNA expression was examined in different brain regions, especially high in hypothalamus. In addition, there was no significant change in CRH mRNA expression in fed group compared with the fasted group in the S. prenanti hypothalamus during short-term fasting. However, CRH gene expression presented significant decrease in the hypothalamus in fasted group compared with the fed group (P < 0.05) on day 7; thereafter, re-feeding could lead to a significant increase in CRH mRNA expression in fasted group on day 9. The results suggest that the CRH may play a critical role in feeding regulation in S. prenanti.

Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study.

PubMed

Supomo, Supomo; Darmawan, Handy; Arjana, Adika Zhulhi

2018-05-22

The presence of altered pulmonary hemodynamics in adult patients with atrial septal defect (ASD) is common. However, there are no observational studies which evaluate the impact of altered pulmonary hemodynamics on the 6-min walk test (6MWT) result. This study aimed to investigate the role of pulmonary hemodynamics in determining 6MWT result of patients with ASD. Forty-six consecutive adult patients with ASD were included in this study. Right heart catheterization was performed to obtain the pulmonary hemodynamics profile. Meanwhile, 6MWT was presented as high or low with cut-off point 350 m. Receiver operating characteristic (ROC) was used for analytical methods. Abnormal functional capacity was indicated by ROC result of mPAP cut-off value of > 24 mmHg (p = 0.0243; AUC = 0.681). The value of PVR > 3.42 woods unit (WU) showed high specificity in determining abnormal functional capacity (p = 0.0069; AUC = 0.713). Flow ratio with cut-off point ≤4.89 had the highest sensitivity (100%) (p = 0.8300; AUC = 0.520). Pulmonary hemodynamics can serve as an indicator of 6MWT result in adult ASD patients with values of mPAP> 24 mmHg and PVR > 3.42 WU.

Dynamics of Cytokine-like Activity in the Hyperplasic Ovary of Ex-fissiparous Planarians.

PubMed

Harrath, Abdel Halim; Semlali, Abdelhabib; Mansour, Lamjed; Aldahmash, Waleed; Omar, Suliman Y Al; Anazi, Mohamed S Al; Nyengaard, Jens R; Alwasel, Saleh

2017-02-01

The origin of infertility in the hyperplasic ovary of ex-fissiparous planarians remains poorly understood. In a previous study we demonstrated that a complex process of early autophagy, followed by apoptotic processes, occurs in the hyperplasic ovary of the freshwater planarian Dugesia arabica. The present study aimed to investigate whether the mRNA expression levels of selected mRNA-like genes are altered in the hyperplasic ovary of the ex-fissiparous freshwater planarian D. arabica compared to the normal ovary. Using human cytokine-specific primers including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), we have successfully amplified by real-time polymerase chain reaction some transcripts that could be similar to those amplified in human. The transcript levels of the human-like transcript (IL-1-like and TNF-α-like) were significantly higher, 4.89- and 3.41-fold, respectively, in the hyperplasic ovary compared to the normal ovary (P < 0.05). However, although IL-6-like levels were higher in the hyperplasic ovary than the normal ovary (2.57-fold), this difference was not significant (P > 0.05). Immunohistochemical labeling supported the quantitative real-time PCR, showing that, like their respective mRNA expression levels, IL-1, IL-6, and TNF-α-like proteins are more highly expressed in the hyperplasic ovary than in the normal ovary.

Antioxidant properties and cytotoxic effects on human cancer cell lines of aqueous fermented and lipophilic quince (Cydonia oblonga Mill.) preparations.

PubMed

Pacifico, Severina; Gallicchio, Marialuisa; Fiorentino, Antonio; Fischer, Anna; Meyer, Ulrich; Stintzing, Florian Conrad

2012-11-01

In the course of a screening program on quince phytochemicals, two complex preparations were in the focus of the present study, i.e., a lipophilic quince wax extract (QWE) and an aqueous fermented one (QAFE). While the phytochemical composition has been described earlier, the intention of the current investigation was to complement these data with an extensive antioxidant screening of these preparations including their radical scavenging and reductive power as well as their antilipoperoxidative properties. The Quince Aqueous Fermented Extract (QAFE) effectively scavenged the radical target species exhibiting ID(50) values equal to 68.8 μg/mL towards DPPH· and 73.7 μg/mL towards the anion superoxide radical. Quince wax extract (QWE) was more effective at preventing the formation of thiobarbituric reactive species than QAFE exhibiting an ID(50) value equal to 48.9 μg/mL. Moreover the cytotoxic effects towards human HepG2, A549, and HeLa cell lines were evaluated. The two preparations exerted a different effect on the proliferation of the three tested cell lines. Noteworthy, QAFE was almost always more active than QWE but, sometimes, its effects seemed to be strongly dependent on exposure time. Data obtained demonstrate clearly that both hydrophilic and lipophilic quince preparations are non-toxic and exert health-promoting properties. Copyright © 2012 Elsevier Ltd. All rights reserved.

Bacterial and primary production in the pelagic zone of the Kara Sea

NASA Astrophysics Data System (ADS)

Sazhin, A. F.; Romanova, N. D.; Mosharov, S. A.

2010-10-01

Data on the bacterial and primary production, which were obtained simultaneously for the same water samples, are presented for three regions of the Kara Sea. The samples were collected for the transect westwards of the Yamal Peninsula, along the St. Anna Trough, and the transect in Ob Bay. Direct counts of the DAPI-stained bacterial cells were performed. The bacterial production and grazing rates were determined using a direct method when metabolic inhibitors vancomycin and penicillin were added. The primary production rates were estimated using the 14C method. The average primary production was 112.6, 58.5, and 28.7 mg C m-2 day-1, and the bacterial production was 12.8, 48.9, and 81.6 mg C m-2 day-1 along the Yamal Peninsula, the St. Anna Trough, and Ob Bay, respectively. The average bacterial carbon demand was 34.6, 134.5, and 220.4 mg C m-2 day-1 for these regions, respectively. The data obtained lead us to conclude that the phytoplankton-synthesized organic matter is generally insufficient to satisfy the bacterial carbon demand and may be completely assimilated via the heterotrophic processes in the marine ecosystems. Therefore, the bacterial activity and, consequently, the amount of the synthesized biomass (i.e., the production) both depend directly on the phytoplankton’s condition and activity. We consider these relationships to be characteristics of the Kara Sea’s biota.

The relationship among work-family conflict and enhancement, organizational work-family culture, and work outcomes for older working women.

PubMed

Gordon, Judith R; Whelan-Berry, Karen S; Hamilton, Elizabeth A

2007-10-01

This article examines the relationship among work-family conflict and enhancement, organizational work-family culture, and four work outcomes for 489 working women over the age of 50. Survey results from two U.S. health care organizations and one U.S. financial services organization indicate that older working women experience differing amounts of work-to-family conflict, family-to-work conflict, work-to-family enhancement, and family-to-work enhancement. Hypotheses relating organizational work-family culture to work-family conflict and enhancement were partially supported, and hypotheses relating conflict and enhancement to four work outcomes were partially supported. Work-to-family conflict and work-to-family enhancement partially mediate the relationship between organizational work-family culture and selected work outcomes. Implications for theory and practice, limitations of this study, and directions for future research are also presented.

New size-expanded RNA nucleobase analogs: a detailed theoretical study.

PubMed

Zhang, Laibin; Zhang, Zhenwei; Ren, Tingqi; Tian, Jianxiang; Wang, Mei

2015-04-05

Fluorescent nucleobase analogs have attracted much attention in recent years due to their potential applications in nucleic acids research. In this work, four new size-expanded RNA base analogs were computationally designed and their structural, electronic, and optical properties are investigated by means of DFT calculations. The results indicate that these analogs can form stable Watson-Crick base pairs with natural counterparts and they have smaller ionization potentials and HOMO-LUMO gaps than natural ones. Particularly, the electronic absorption spectra and fluorescent emission spectra are calculated. The calculated excitation maxima are greatly red-shifted compared with their parental and natural bases, allowing them to be selectively excited. In gas phase, the fluorescence from them would be expected to occur around 526, 489, 510, and 462 nm, respectively. The influences of water solution and base pairing on the relevant absorption spectra of these base analogs are also examined. Copyright © 2015 Elsevier B.V. All rights reserved.

Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study.

PubMed

Chen, Zhengming; Iona, Andri; Parish, Sarah; Chen, Yiping; Guo, Yu; Bragg, Fiona; Yang, Ling; Bian, Zheng; Holmes, Michael V; Lewington, Sarah; Lacey, Ben; Gao, Ruqin; Liu, Fang; Zhang, Zengzhi; Chen, Junshi; Walters, Robin G; Collins, Rory; Clarke, Robert; Peto, Richard; Li, Liming

2018-06-01

China has high stroke rates despite the population being relatively lean. Uncertainty persists about the relevance of adiposity to risk of stroke types. We aimed to assess the associations of adiposity with incidence of stroke types and effect mediation by blood pressure in Chinese men and women. The China Kadoorie Biobank enrolled 512 891 adults aged 30-79 years from ten areas (five urban and five rural) during 2004-08. During a median 9 years (IQR 8-10) of follow-up, 32 448 strokes (about 90% confirmed by neuroimaging) were recorded among 489 301 participants without previous cardiovascular disease. Cox regression analysis was used to produce adjusted hazard ratios (HRs) for ischaemic stroke (n=25 210) and intracerebral haemorrhage (n=5380) associated with adiposity. Mean baseline body-mass index (BMI) was 23·6 kg/m 2 (SD 3·2), and 331 723 (67·8%) participants had a BMI of less than 25 kg/m 2 . Throughout the range examined (mean 17·1 kg/m 2 [SD 0·9] to 31·7 kg/m 2 [2·0]), each 5 kg/m 2 higher BMI was associated with 8·3 mm Hg (SE 0·04) higher systolic blood pressure. BMI was positively associated with ischaemic stroke, with an HR of 1·30 (95% CI 1·28-1·33 per 5 kg/m 2 higher BMI), which was generally consistent with that predicted by equivalent differences in systolic blood pressure (1·25 [1·24-1·26]). The HR for intracerebral haemorrhage (1·11 [1·07-1·16] per 5 kg/m 2 higher BMI) was less extreme, and much weaker than that predicted by the corresponding difference in systolic blood pressure (1·48 [1·46-1·50]). Other adiposity measures showed similar associations with stroke types. After adjustment for usual systolic blood pressure, the positive associations with ischaemic stroke were attenuated (1·05 [1·03-1·07] per 5 kg/m 2 higher BMI); for intracerebral haemorrhage, they were reversed (0·73 [0·70-0·77]). High adiposity (BMI >23 kg/m 2 ) accounted for 14·7% of total stroke (16·5% of ischaemic stroke and 6·7% of intracerebral haemorrhage). In Chinese adults, adiposity was strongly positively associated with ischaemic stroke, chiefly through its effect on blood pressure. For intracerebral haemorrhage, leanness, either per se or through some other factor (or factors), might increase risk, offsetting the protective effects of lower blood pressure. UK Wellcome Trust, UK Medical Research Council, British Heart Foundation, Cancer Research UK, Kadoorie Charitable Foundation, Chinese Ministry of Science and Technology, Chinese National Natural Science Foundation. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.

Modulation Effects in Multi-Section Semiconductor Lasers (Postprint)

DTIC Science & Technology

2013-01-01

resonant modulation of semiconductor lasers beyond relaxation oscillation frequency,” Appl. Phys. Lett., 63, 1459–1461 (1993). [26] J. Helms and K. Petermann ...5, 4–6 (1993). [28] K. Petermann , “External optical feedback phenomena in semiconductor lasers,” IEEE J. Sel. Top. Quantum Elec- tron., 1, 480–489

76 FR 32896 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... buildings. Comments on any aspect of the Flood Insurance Study and FIRM, other than the proposed BFEs, will... Creek confluence. At the downstream side +489 +491 of Oak Gate Lane. Long Branch (of Duck Creek) Bypass.. At the upstream side of +498 +490 City of Mesquite. the Long Branch (of Duck Creek) confluence...

75 FR 3249 - Wyeth Pharmaceuticals, a Subsidiary of Wyeth, Currently Known as Pfizer, Rouses Point, NY; Wyeth...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

...,489B] Wyeth Pharmaceuticals, a Subsidiary of Wyeth, Currently Known as Pfizer, Rouses Point, NY; Wyeth Pharmaceuticals, a Subsidiary of Wyeth, Currently Known as Pfizer, Chazy, NY; Wyeth Pharmaceuticals, a Subsidiary... Adjustment Assistance on November 24, 2009, applicable to workers of Wyeth Pharmaceuticals, a subsidiary of...

78 FR 63984 - Medicare and Medicaid Programs: Application From the Joint Commission for Continued Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... conducting required surveys; capacity to furnish information for use in enforcement activities; monitoring... are at 42 CFR part 489 and those pertaining to activities relating to the survey and certification of... facilities. ++ The Joint Commission's processes and procedures for monitoring an HHA found out of compliance...

77 FR 31362 - Medicare and Medicaid Programs; Application From the Community Health Accreditation Program for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

.... Regulations concerning provider agreements are at 42 CFR part 489 and those pertaining to activities relating...; resources for conducting required surveys; capacity to furnish information for use in enforcement activities; monitoring procedures for provider entities found not in compliance with the conditions or requirements; and...

76 FR 66929 - Medicare and Medicaid Programs; The American Association for Accreditation of Ambulatory Surgery...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... use in enforcement activities; monitoring procedures for provider entities found not in compliance... concerning provider agreements are at 42 CFR part 489 and those pertaining to activities relating to the... facilities. --The processes and procedures AAAASF uses for monitoring RHCs found out of compliance with...

78 FR 12325 - Medicare and Medicaid Programs; Application From the Center for Improvement in Healthcare Quality...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... use in enforcement activities; monitoring procedures for provider entities found not in compliance... located at 42 CFR part 489 and those pertaining to activities relating to the survey and certification of... accredited facilities. ++ CIHQ's processes and procedures for monitoring a hospital that is out of compliance...

76 FR 28040 - Medicare and Medicaid Programs; Application by the Joint Commission for Continued Deeming...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... furnish information for use in enforcement activities; monitoring procedures for provider entities found... agreements are at 42 CFR part 489 and those pertaining to activities relating to the survey and certification... for monitoring CAHs found out of compliance with the Joint Commission's program requirements. These...

What to Do about Being Overwhelmed: Graduate Students, Stress and University Services

ERIC Educational Resources Information Center

Oswalt, Sara B.; Riddock, Christina C.

2007-01-01

Few studies have examined graduate students and stress. At a large, Southeastern university, 223 graduate students completed a survey about factors contributing their stress, current coping strategies and related university services. A majority felt stressed (48.9%) or very stressed (24.7%). There were significant differences in coping strategies…

24 CFR 570.489 - Program administrative requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... funds reallocated by HUD to the State which are distributed during the time the final Statement for the..., less the costs incidental to the generation of the income; (iv) Gross income from the use or rental of... activity that was constructed or improved with CDBG funds, less the costs incidental to the generation of...

24 CFR 570.489 - Program administrative requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... funds reallocated by HUD to the State which are distributed during the time the final Statement for the..., less the costs incidental to the generation of the income; (iv) Gross income from the use or rental of... activity that was constructed or improved with CDBG funds, less the costs incidental to the generation of...

40 CFR 63.492 - Batch front-end process vents-reporting requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... days after the process change is made or with the next Periodic Report, whichever is later. The owner... next Periodic Report, whichever is later. The following information shall be submitted: (1) A... than those specified in § 63.489(b) and listed in Table 6 of this subpart or requests approval to...

40 CFR 63.492 - Batch front-end process vents-reporting requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... days after the process change is made or with the next Periodic Report, whichever is later. The owner... next Periodic Report, whichever is later. The following information shall be submitted: (1) A... than those specified in § 63.489(b) and listed in Table 6 of this subpart or requests approval to...

Alternative Pathways to Legitimacy: Promotional Practices in the Ontario For-Profit College Sector

ERIC Educational Resources Information Center

Pizarro Milian, Roger; Quirke, Linda

2017-01-01

This study empirically examines how for-profit career colleges in Ontario, Canada market themselves to prospective students. It uses a mixed-methods approach to review the content of 489 online promotional profiles representing 375 unique for-profit colleges. It finds that for-profit colleges adopt several distinct marketing strategies, including…

Long-Term Effects of Otitis Media a Ten-Year Cohort Study of Alaskan Eskimo Children

ERIC Educational Resources Information Center

Kaplan, Gary J.; And Others

1973-01-01

Histories of ear disease, otoscopic examinations, and audiologic, intelligence, and achievement tests were obtained from a cohort of 489 Alaskan Eskimo children, followed through the first 10 years of life, to determine whether otitis media (middle ear inflammation) deleteriously affected intellectual functioning and achievement in school.…

40 CFR 63.489 - Batch front-end process vents-monitoring equipment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... installed in the gas stream immediately before and after the catalyst bed. (2) Where a flare is used, a device (including, but not limited to, a thermocouple, ultra-violet beam sensor, or infrared sensor... at the scrubber influent for liquid flow. Gas stream flow shall be determined using one of the...

40 CFR 63.489 - Batch front-end process vents-monitoring equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... installed in the gas stream immediately before and after the catalyst bed. (2) Where a flare is used, a device (including, but not limited to, a thermocouple, ultra-violet beam sensor, or infrared sensor... at the scrubber influent for liquid flow. Gas stream flow shall be determined using one of the...

38 CFR 4.71a - Schedule of ratings-musculoskeletal system.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., diagnostic codes 5004 through 5009, rate the disability as rheumatoid arthritis. 5010Arthritis, due to trauma...: See §§ 4.88b and 4.89. 5002Arthritis rheumatoid (atrophic) As an active process: With constitutional... osteoarthritis): Degenerative arthritis established by X-ray findings will be rated on the basis of limitation of...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2013 CFR

2013-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2014 CFR

2014-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2010 CFR

2010-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2011 CFR

2011-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2012 CFR

2012-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

77 FR 46694 - Certain Pasta From Turkey: Notice of Preliminary Results of the 2010-2011 Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... DEPARTMENT OF COMMERCE International Trade Administration [A-489-805] Certain Pasta From Turkey... (the Department) is conducting an administrative review of the antidumping duty order on certain pasta (pasta) from Turkey for the period of review (POR) July 1, 2010, through June 30, 2011. The Department...